Science.gov

Sample records for puzzle imperfect knowledge

  1. KnowledgePuzzle: A Browsing Tool to Adapt the Web Navigation Process to the Learner's Mental Model

    ERIC Educational Resources Information Center

    AlAgha, Iyad

    2012-01-01

    This article presents KnowledgePuzzle, a browsing tool for knowledge construction from the web. It aims to adapt the structure of web content to the learner's information needs regardless of how the web content is originally delivered. Learners are provided with a meta-cognitive space (e.g., a concept mapping tool) that enables them to plan…

  2. Imperfect Unit.

    ERIC Educational Resources Information Center

    McCarthy, Katherine

    This unit provides visual activities to engage students in learning the imperfect tense in Spanish. Upon completion of the unit, students will be able to do the following: identify imperfect tense conjugation in children's books; conjugate verbs in the imperfect tense; list uses of the imperfect tense; discriminate between the imperfect tense and…

  3. Puzzling Mechanisms

    ERIC Educational Resources Information Center

    van Deventer, M. Oskar

    2009-01-01

    The basis of a good mechanical puzzle is often a puzzling mechanism. This article will introduce some new puzzling mechanisms, like two knots that engage like gears, a chain whose links can be interchanged, and flat gears that do not come apart. It illustrates how puzzling mechanisms can be transformed into real mechanical puzzles, e.g., by…

  4. Puzzle Corner.

    ERIC Educational Resources Information Center

    Andrews, Ian A.

    1992-01-01

    Presents a crossword puzzle and a word find puzzle. Offers clues dealing with member nations in the British Commonwealth. Includes an answer key for the crossword puzzle. Suggests sources of information on the Commonwealth. (DK)

  5. Predicting community responses to perturbations in the face of imperfect knowledge and network complexity

    USGS Publications Warehouse

    Novak, Mark; Wootton, J. Timothy; Doak, Daniel F.; Emmerson, Mark; Estes, James A.; Tinker, M. Timothy

    2011-01-01

    How best to predict the effects of perturbations to ecological communities has been a long-standing goal for both applied and basic ecology. This quest has recently been revived by new empirical data, new analysis methods, and increased computing speed, with the promise that ecologically important insights may be obtainable from a limited knowledge of community interactions. We use empirically based and simulated networks of varying size and connectance to assess two limitations to predicting perturbation responses in multispecies communities: (1) the inaccuracy by which species interaction strengths are empirically quantified and (2) the indeterminacy of species responses due to indirect effects associated with network size and structure. We find that even modest levels of species richness and connectance (∼25 pairwise interactions) impose high requirements for interaction strength estimates because system indeterminacy rapidly overwhelms predictive insights. Nevertheless, even poorly estimated interaction strengths provide greater average predictive certainty than an approach that uses only the sign of each interaction. Our simulations provide guidance in dealing with the trade-offs involved in maximizing the utility of network approaches for predicting dynamics in multispecies communities.

  6. Predicting community responses to perturbations in the face of imperfect knowledge and network complexity

    USGS Publications Warehouse

    Novak, M.; Wootton, J.T.; Doak, D.F.; Emmerson, M.; Estes, J.A.; Tinker, M.T.

    2011-01-01

    How best to predict the effects of perturbations to ecological communities has been a long-standing goal for both applied and basic ecology. This quest has recently been revived by new empirical data, new analysis methods, and increased computing speed, with the promise that ecologically important insights may be obtainable from a limited knowledge of community interactions. We use empirically based and simulated networks of varying size and connectance to assess two limitations to predicting perturbation responses in multispecies communities: (1) the inaccuracy by which species interaction strengths are empirically quantified and (2) the indeterminacy of species responses due to indirect effects associated with network size and structure. We find that even modest levels of species richness and connectance (??25 pairwise interactions) impose high requirements for interaction strength estimates because system indeterminacy rapidly overwhelms predictive insights. Nevertheless, even poorly estimated interaction strengths provide greater average predictive certainty than an approach that uses only the sign of each interaction. Our simulations provide guidance in dealing with the trade-offs involved in maximizing the utility of network approaches for predicting dynamics in multispecies communities. ?? 2011 by the Ecological Society of America.

  7. Blood Type Puzzle.

    ERIC Educational Resources Information Center

    Kelly, Janet

    1997-01-01

    Presents a blood type puzzle that provides a visual, hands-on mechanism by which students can examine blood group reactions. Offers students an opportunity to construct their own knowledge about blood types. (JRH)

  8. Theorising Knowledge Practices: A Missing Piece of the Educational Technology Puzzle

    ERIC Educational Resources Information Center

    Howard, Sarah; Maton, Karl

    2011-01-01

    Educational technology research has been characterised as lacking theoretical frameworks that can enable cumulative knowledge-building across the field. This article explores the value of Legitimation Code Theory (LCT) for addressing these issues by discussing research into the key of integration of information and communication technologies in…

  9. Puzzles & Problems.

    ERIC Educational Resources Information Center

    Murphy, Pat, Ed.

    1993-01-01

    "Exploring" is a magazine of science, art, and human perception, produced by Exploratorium in collaboration with other participating museums. This issue focuses on puzzles and problem solving. Brain teasers, puzzles, and the strategies for solving them are included. Features include: (1) "Homework Assignment #3" (Paul Doherty); (2) "The Case of…

  10. Lockean Puzzles

    ERIC Educational Resources Information Center

    Milligan, Tony

    2007-01-01

    In analytic moral philosophy it is standard to use unrealistic puzzles to set up moral dilemmas of a sort that I will call Lockean Puzzles. This paper will try to pinpoint just what is and what is not problematic about their use as a teaching tool or component part of philosophical arguments. I will try to flesh out the claim that what may be lost…

  11. Deductive Puzzling

    ERIC Educational Resources Information Center

    Wanko, Jeffrey J.

    2010-01-01

    To help fifth- through eighth-grade students develop their deductive reasoning skills, the author used a ten-week supplementary curriculum so that students could answer logic questions. The curriculum, a series of lessons built around language-independent logic puzzles, has been used in classrooms of fifth through eighth grades. In most cases,…

  12. Incomplete Puzzle

    NASA Technical Reports Server (NTRS)

    2006-01-01

    15 April 2006 This Mars Global Surveyor (MGS) Mars Orbiter Camera (MOC) image shows a mid-summer view of a portion of the south polar residual cap of Mars. The large, relatively flat-lying, puzzle-like pieces in this scene are mesas composed largely of solid carbon dioxide.

    Location near: 85.5oS, 76.8oW Image width: 3 km (1.9 mi) Illumination from: upper left Season: Southern Summer

  13. Irregularities in Imperfective Derivation

    ERIC Educational Resources Information Center

    Levin, Maurice I.

    1977-01-01

    This article discusses presentation of Russian conjugation via the one-stem system advocated by Lipson and Townsend, and attempts a more unified and complete presentation of irregularities in imperfect derivation. Two major irregularities are occurrence of an unexpected suffix and unpredictable alternation in the root of the derived imperfective.…

  14. Puzzles, Pastimes, Problems.

    ERIC Educational Resources Information Center

    Eperson, D. B.

    1985-01-01

    Presents six mathematical problems (with answers) which focus on: (1) chess moves; (2) patterned numbers; (3) quadratics with rational roots; (4) number puzzles; (5) Euclidean geometry; and (6) Carrollian word puzzles. (JN)

  15. Benjamin Banneker's Mathematical Puzzles.

    ERIC Educational Resources Information Center

    Mahoney, John F.

    2003-01-01

    Benjamin Banneker, a self-taught African American mathematician, kept a journal containing a number of mathematical puzzles. Explores four of these puzzles, 200 years later, with the aid of 21st century technology. (Author/NB)

  16. The Proton Radius Puzzle

    NASA Astrophysics Data System (ADS)

    Downie, E. J.

    2016-03-01

    The proton radius puzzle is the difference between the proton radius as measured with electron scattering and in the excitation spectrum of atomic hydrogen, and that measured with muonic hydrogen spectroscopy. Since the inception of the proton radius puzzle in 2010 by the measurement of Pohl et al.[1], many possible resolutions to the puzzle have been postulated, but, to date, none has been generally accepted. New data are therefore necessary to resolve the issue. We briefly review the puzzle, the proposed solutions, and the new electron scattering and spectroscopy experiments planned and underway. We then introduce the MUSE experiment, which seeks to resolve the puzzle by simultaneously measuring elastic electron and muon scattering on the proton, in both charge states, thereby providing new information to the puzzle. MUSE addresses issues of two-photon effects, lepton universality and, possibly, new physics, while providing simultaneous form factor, and therefore radius, measurements with both muons and electrons.

  17. Puzzling Ways to Learn

    ERIC Educational Resources Information Center

    School Shop, 1975

    1975-01-01

    Four authors present crossword and wordfind puzzles developed for students in the areas of electricity, principles of hydraulics, finishing, construction, thermoplastic materials, patternmaking, wood, occupations, and drafting. (BP)

  18. Imperfection Insensitive Thin Shells

    NASA Astrophysics Data System (ADS)

    Ning, Xin

    The buckling of axially compressed cylindrical shells and externally pressurized spherical shells is extremely sensitive to even very small geometric imperfections. In practice this issue is addressed by either using overly conservative knockdown factors, while keeping perfect axial or spherical symmetry, or adding closely and equally spaced stiffeners on shell surface. The influence of imperfection-sensitivity is mitigated, but the shells designed from these approaches are either too heavy or very expensive and are still sensitive to imperfections. Despite their drawbacks, these approaches have been used for more than half a century. This thesis proposes a novel method to design imperfection-insensitive cylindrical shells subject to axial compression. Instead of following the classical paths, focused on axially symmetric or high-order rotationally symmetric cross-sections, the method in this thesis adopts optimal symmetry-breaking wavy cross-sections (wavy shells). The avoidance of imperfection sensitivity is achieved by searching with an evolutionary algorithm for smooth cross-sectional shapes that maximize the minimum among the buckling loads of geometrically perfect and imperfect wavy shells. It is found that the shells designed through this approach can achieve higher critical stresses and knockdown factors than any previously known monocoque cylindrical shells. It is also found that these shells have superior mass efficiency to almost all previously reported stiffened shells. Experimental studies on a design of composite wavy shell obtained through the proposed method are presented in this thesis. A method of making composite wavy shells and a photogrametry technique of measuring full-field geometric imperfections have been developed. Numerical predictions based on the measured geometric imperfections match remarkably well with the experiments. Experimental results confirm that the wavy shells are not sensitive to imperfections and can carry axial compression

  19. The Anatomy Puzzle Book.

    ERIC Educational Resources Information Center

    Jacob, Willis H.; Carter, Robert, III

    This document features review questions, crossword puzzles, and word search puzzles on human anatomy. Topics include: (1) Anatomical Terminology; (2) The Skeletal System and Joints; (3) The Muscular System; (4) The Nervous System; (5) The Eye and Ear; (6) The Circulatory System and Blood; (7) The Respiratory System; (8) The Urinary System; (9) The…

  20. The Puzzle Design Activity.

    ERIC Educational Resources Information Center

    Meyer, Marc E.

    1983-01-01

    A sampling of puzzles and games produced by students at North Rockland High School (New York) are presented as an example of a way student-designed activities can be used to cover a specific unit within the health education curriculum. Produced by 9th and 10th graders, the unit on alcohol consists of puzzles and word games using related vocabulary…

  1. The Textual Puzzle Technique.

    ERIC Educational Resources Information Center

    Lanier, Dorothy C.

    Textual puzzles may be used in freshman composition or introduction to writing courses to emphasize word order and subject-predicate agreement. These sentence puzzles demonstrate that the English language depends primarily upon word order to convey meaning, and assist students to avoid blending statement and question word order in their sentences…

  2. Puzzles and Hunts.

    ERIC Educational Resources Information Center

    Weissblum, Aaron

    2000-01-01

    A company designs and delivers treasure and scavenger hunts for corporate and institutional clients. Groups are divided into teams that must solve puzzles for directions or clues. The hunts build creativity, teamwork, communication skills, and an appreciation of others' strengths. An insert includes a four-puzzle mini-treasure hunt. (TD)

  3. Tangrams: Puzzles of Art

    ERIC Educational Resources Information Center

    Fee, Brenda

    2009-01-01

    Challenging one's brain is the beginning of making great art. Tangrams are a great way to keep students thinking about their latest art project long after leaving the classroom. A tangram is a Chinese puzzle. The earliest known reference to tangrams appears in a Chinese book dated 1813, but the puzzles existed long before that date. The puzzle…

  4. A Disciplined Chemical Puzzle

    ERIC Educational Resources Information Center

    Peris, Miguel

    2007-01-01

    A puzzle was developed as a resource for teaching intermediate chemistry students where they need to use general intelligence and logic skills. The puzzle involves identification of name, age, subdiscipline of chemistry and position of 6 students around the table by using certain data provided to them.

  5. Imperfect mirror copies of the standard model

    NASA Astrophysics Data System (ADS)

    Berryman, Jeffrey M.; de Gouvêa, André; Hernández, Daniel; Kelly, Kevin J.

    2016-08-01

    Inspired by the standard model of particle physics, we discuss a mechanism for constructing chiral, anomaly-free gauge theories. The gauge symmetries and particle content of such theories are identified using subgroups and complex representations of simple anomaly-free Lie groups, such as S O (10 ) or E6. We explore, using mostly S O (10 ) and the 16 representation, several of these "imperfect copies" of the standard model, including U (1 )N theories, S U (5 )⊗U (1 ) theories, S U (4 )⊗U (1 )2 theories with 4-plets and 6-plets, and chiral S U (3 )⊗S U (2 )⊗U (1 ) . A few general properties of such theories are discussed, as is how they might shed light on nonzero neutrino masses, the dark matter puzzle, and other phenomenologically relevant questions.

  6. Learning with imperfectly labeled patterns

    NASA Technical Reports Server (NTRS)

    Chittineni, C. B.

    1979-01-01

    The problem of learning in pattern recognition using imperfectly labeled patterns is considered. The performance of the Bayes and nearest neighbor classifiers with imperfect labels is discussed using a probabilistic model for the mislabeling of the training patterns. Schemes for training the classifier using both parametric and non parametric techniques are presented. Methods for the correction of imperfect labels were developed. To gain an understanding of the learning process, expressions are derived for success probability as a function of training time for a one dimensional increment error correction classifier with imperfect labels. Feature selection with imperfectly labeled patterns is described.

  7. Accelerating Student Learning of Technology Terms: "The Crossword Puzzle Exercise"

    ERIC Educational Resources Information Center

    Whisenand, Thomas G.; Dunphy, Steven M.

    2010-01-01

    The authors suggest using an alternative teaching methodology to impart knowledge regarding information systems phraseology and vocabulary. Specifically, a series of crossword puzzles or scrabbles are used to present information system (IS) terminology to students in an introductory business information systems course. The puzzle terms and answers…

  8. Imperfect Dark Matter

    NASA Astrophysics Data System (ADS)

    Mirzagholi, Leila; Vikman, Alexander

    2015-06-01

    We consider cosmology of the recently introduced mimetic matter with higher derivatives (HD). Without HD this system describes irrotational dust—Dark Matter (DM) as we see it on cosmologically large scales. DM particles correspond to the shift-charges—Noether charges of the shifts in the field space. Higher derivative corrections usually describe a deviation from the thermodynamical equilibrium in the relativistic hydrodynamics. Thus we show that mimetic matter with HD corresponds to an imperfect DM which: i) renormalises the Newton's constant in the Friedmann equations, ii) has zero pressure when there is no extra matter in the universe, iii) survives the inflationary expansion which puts the system on a dynamical attractor with a vanishing shift-charge, iv) perfectly tracks any external matter on this attractor, v) can become the main (and possibly the only) source of DM, provided the shift-symmetry in the HD terms is broken during some small time interval in the radiation domination époque. In the second part of the paper we present a hydrodynamical description of general anisotropic and inhomogeneous configurations of the system. This imperfect mimetic fluid has an energy flow in the field's rest frame. We find that in the Eckart and in the Landau-Lifshitz frames the mimetic fluid possesses nonvanishing vorticity appearing already at the first order in the HD. Thus, the structure formation and gravitational collapse should proceed in a rather different fashion from the simple irrotational DM models.

  9. Learning receptor positions from imperfectly known motions

    NASA Technical Reports Server (NTRS)

    Ahumada, Albert J., Jr.; Mulligan, Jeffrey B.

    1990-01-01

    An algorithm is described for learning image interpolation functions for sensor arrays whose sensor positions are somewhat disordered. The learning is based on failures of translation invariance, so it does not require knowledge of the images being presented to the visual system. Previously reported implementations of the method assumed the visual system to have precise knowledge of the translations. It is demonstrated that translation estimates computed from the imperfectly interpolated images can have enough accuracy to allow the learning process to converge to a correct interpolation.

  10. Boggle Logic Puzzles: Minimal Solutions

    ERIC Educational Resources Information Center

    Needleman, Jonathan

    2013-01-01

    Boggle logic puzzles are based on the popular word game Boggle played backwards. Given a list of words, the problem is to recreate the board. We explore these puzzles on a 3 x 3 board and find the minimum number of three-letter words needed to create a puzzle with a unique solution. We conclude with a series of open questions.

  11. More Pebble Puzzles.

    ERIC Educational Resources Information Center

    Gibbs, William M.

    This booklet is a collection of puzzles, investigations, and games. They are designed to be used with large objects such as tins or stones and diagrams marked on the ground. The children are to be encouraged to use an experimental, trial-and-error approach at first, and then develop methods of solution. (MNS)

  12. La Francophonie. Puzzle Corner.

    ERIC Educational Resources Information Center

    Andrews, Ian A.

    2000-01-01

    Discusses the organization La Francophonie, which is an international community of people who speak French and convene to address issues. Presents a crossword puzzle that introduces readers to some of the nations involved in La Francophonie. Provides the across and down clues, a word list, and answer key. (CMK)

  13. Nature's Greatest Puzzles

    SciTech Connect

    Quigg, Chris; /Fermilab

    2005-02-01

    It is a pleasure to be part of the SLAC Summer Institute again, not simply because it is one of the great traditions in our field, but because this is a moment of great promise for particle physics. I look forward to exploring many opportunities with you over the course of our two weeks together. My first task in talking about Nature's Greatest Puzzles, the title of this year's Summer Institute, is to deconstruct the premise a little bit.

  14. Equivalent Imperfections In Arched Structures

    NASA Astrophysics Data System (ADS)

    Dallemule, Marian

    2015-09-01

    There are currently three design methods to verify the in-plane buckling of an arched structure: substitute member method, the method of equivalent imperfection with recommendations for arched bridges, and the equivalent unique global and local initial imperfection method (EUGLI), which uses the critical elastic buckling mode as an imperfection. The latter method is included in the EN 1993-1-1 cl. 5.3.2 (11) since 2002; however, to this day it is neither utilized in the design practice nor is it incorporated in ordinary structural analysis software. The main purpose of this article is to show the application of the proposed methods in a step-by-step manner to the numerical example considered and to compare these design methods for various arched structures. Verification of the in-plane buckling of an arch is explained in detail.

  15. A Microscale Oxidation Puzzle

    NASA Astrophysics Data System (ADS)

    Pelter, Michael W.; Macudzinski, Rebecca M.; Passarelli, Mary Ellen

    2000-11-01

    We have adapted oxidation of an alcohol with sodium hypochlorite solution to a "puzzle" approach by using a diol as the substrate for oxidation. The diols under investigation have both a primary and a secondary hydroxyl group. There are three possible outcomes to the reaction: (i) only the primary alcohol is oxidized to the aldehyde (or carboxylic acid); (ii) only the secondary alcohol is oxidized to the ketone; or (iii) both alcohols are oxidized. The assignment is to perform the reaction and determine the structure of the product through interpretation of the IR spectrum. Examples using two commercially available diols are shown.

  16. Pebble Puzzles. A Source Book of Simple Puzzles and Problems.

    ERIC Educational Resources Information Center

    Gibbs, William M.

    This booklet is a collection of puzzles, games, and investigations. All that children need are some stones or shells, on some of which they must write numerals. For playing with the whole class, the game or puzzles may be marked out on the floor or in sand; in that case, larger objects such as small rocks and empty tins may be used. Children are…

  17. Three Puzzles for Organic Laboratory.

    ERIC Educational Resources Information Center

    Todd, David; Pickering, Miles

    1988-01-01

    Notes that laboratory work should be more oriented towards puzzle solving rather than technique or illustration. Offers three organic laboratory puzzles which can be solved by melting point alone. Involves lab work at the 100-200-mg scale but still uses conventional glassware. (MVL)

  18. Puzzle geometry and rigidity

    NASA Astrophysics Data System (ADS)

    Smania, Daniel

    2007-07-01

    We describe a new and robust method to prove rigidity results in complex dynamics. The new ingredient is the geometry of the critical puzzle pieces: under control of geometry and ``complex bounds'', two generalized polynomial-like maps which admit a topological conjugacy, quasiconformal outside the filled-in Julia set, are indeed quasiconformally conjugate. The proof uses a new abstract removability-type result for quasiconformal maps, following ideas of Heinonen and Koskela and of Kallunki and Koskela, optimized for applications in complex dynamics. We prove, as the first application of this new method, that, for even criticalities distinct from two, the period two cycle of the Fibonacci renormalization operator is hyperbolic with 1 -dimensional unstable manifold.

  19. Modeling Being "Lost": Imperfect Situation Awareness

    NASA Technical Reports Server (NTRS)

    Middleton, Victor E.

    2011-01-01

    Being "lost" is an exemplar of imperfect Situation Awareness/Situation Understanding (SA/SU) -- information/knowledge that is uncertain, incomplete, and/or just wrong. Being "lost" may be a geo-spatial condition - not knowing/being wrong about where to go or how to get there. More broadly, being "lost" can serve as a metaphor for uncertainty and/or inaccuracy - not knowing/being wrong about how one fits into a larger world view, what one wants to do, or how to do it. This paper discusses using agent based modeling (ABM) to explore imperfect SA/SU, simulating geo-spatially "lost" intelligent agents trying to navigate in a virtual world. Each agent has a unique "mental map" -- its idiosyncratic view of its geo-spatial environment. Its decisions are based on this idiosyncratic view, but behavior outcomes are based on ground truth. Consequently, the rate and degree to which an agent's expectations diverge from ground truth provide measures of that agent's SA/SU.

  20. The Puzzling Ophiuchus Stream

    NASA Astrophysics Data System (ADS)

    Kohler, Susanna

    2016-01-01

    Dwarf galaxies or globular clusters orbiting the Milky Way can be pulled apart by tidal forces, leaving behind a trail of stars known as a stellar stream. One such trail, the Ophiuchus stream, has posed a serious dynamical puzzle since its discovery. But a recent study has identified four stars that might help resolve this streams mystery.Conflicting TimescalesThe stellar stream Ophiuchus was discovered around our galaxy in 2014. Based on its length, which appears to be 1.6 kpc, we can calculate the time that has passed since its progenitor was disrupted and the stream was created: ~250 Myr. But the stars within it are ~12 Gyr old, and the stream orbits the galaxy with a period of ~350 Myr.Given these numbers, we can assume that Ophiuchuss progenitor completed many orbits of the Milky Way in its lifetime. So why would it only have been disrupted 250 million years ago?Fanning StreamLed by Branimir Sesar (Max Planck Institute for Astronomy), a team of scientists has proposed an idea that might help solve this puzzle. If the Ophiuchus stellar stream is on a chaotic orbit common in triaxial potentials, which the Milky Ways may be then the stream ends can fan out, with stars spreading in position and velocity.The fanned part of the stream, however, would be difficult to detect because of its low surface brightness. As a result, the Ophiuchus stellar stream could actually be longer than originally measured, implying that it was disrupted longer ago than was believed.Search for Fan StarsTo test this idea, Sesar and collaborators performed a search around the ends of the stream, looking for stars thatare of the right type to match the stream,are at the predicted distance of the stream,are located near the stream ends, andhave velocities that match the stream and dont match the background halo stars.Histogram of the heliocentric velocities of the 43 target stars. Six stars have velocities matching the stream velocity. Two of these are located in the main stream; the other

  1. Sleep for Kids: Games and Puzzles

    MedlinePlus

    Games and Puzzles These games and puzzles can help you learn more about sleep! Learn about sleep with this fun crossword puzzle! Test your memory ... can't sleep? • dreams • • bring out the stars • games and puzzles • pj bear booklet • • home • about us • ...

  2. [The Parkinson puzzle].

    PubMed

    Guseo, András

    2012-12-30

    Parkinson's disease is one of the most frequent progressive degenerative disorders with unknown origin of the nervous system. The commutation of the disease on Guam led to the discovery of a neurotoxin which was also found in other continents. This neurotoxin was identified in the common cyanobacteria (blue-green algae). Early clinical observations suggested some loose correlations with gastric and duodenal ulcer and Parkinson's disease, while recent studies revealed a toxin, almost identical to that found in cyanobacteria in one strain of Helicobacter pylori, which proved to cause Parkinson like symptoms in animals. Therefore, it cannot be ruled out that there is a slowly progressive poisoning in Parkinson's disease. The disease specific alpha-sinuclein inclusions can be found in nerve cells of the intestinal mucosa far before the appearance of clinical symptoms indicating that the disease may start in the intestines. These results are strengthened by the results of Borody's fecal transplants, after which in Parkinson patients showed a symptomatic improvement. Based on these observations the Parkinson puzzle is getting complete. Although these observations are not evidence based, they may indicate a new way for basic clinical research, as well as a new way of thinking for clinicians. These new observations in psycho-neuro-immunology strengthen the fact that immunological factors may also play a critical factor facilitating local cell necrosis which may be influenced easily. PMID:23261994

  3. Puzzle Them First! Motivating Adolescent Readers with Question-Finding

    ERIC Educational Resources Information Center

    Ciardiello, A. Vincent

    2007-01-01

    In this book, the author suggests that to truly learn, students should be puzzled about new knowledge. Question-finding, the unique strategy described in the book, fosters this learning by leading adolescent students to probe the multiple meanings of text and ask challenging, open-ended questions. Focus units illustrate how teachers can use…

  4. Seismic response of LMFBR tanks with imperfections

    SciTech Connect

    Gvildys, J.; Ma, D.C.; Chang, Y.W.

    1985-01-01

    This paper deals with seismic responses of imperfect circular tanks. Physical imperfection due to manufacturing tolerances and numerical imperfection due to finite element spatial discretization are described. Numerical imperfections produced by 4-node and 9-node Lagrangian shell elements are examined. A convergence study is performed in which the number of the shell elements required to capture the dominant ''out-of-roundness'' modes under seismic excitations is determined. The response of a shell with a cos4theta imperfection due to manufacturing tolerances is compared with that of a perfect circular shell to demonstrate the effects of imperfection on the axial stresses of the shell under seismic conditions. 3 refs., 4 figs., 2 tabs.

  5. The PRad experiment and the proton radius puzzle

    SciTech Connect

    Gasparian, Ashot H.

    2014-06-01

    New results from the recent muonic hydrogen experiments seriously questioned our knowledge of the proton charge radius, r_p. The new value, with its unprecedented less than sub-percent precision, is currently up to eight standard deviation smaller than the average value from all previous experiments, triggering the well-known "proton charge radius puzzle" in nuclear and atomic physics. The PRad collaboration is currently preparing a novel, magnetic-spectrometer-free ep scattering experiment in Hall B at JLab for a new independent r_p measurement to address this growing "puzzle" in physics.

  6. Imperfect Cloning Operations in Algebraic Quantum Theory

    NASA Astrophysics Data System (ADS)

    Kitajima, Yuichiro

    2015-01-01

    No-cloning theorem says that there is no unitary operation that makes perfect clones of non-orthogonal quantum states. The objective of the present paper is to examine whether an imperfect cloning operation exists or not in a C*-algebraic framework. We define a universal -imperfect cloning operation which tolerates a finite loss of fidelity in the cloned state, and show that an individual system's algebra of observables is abelian if and only if there is a universal -imperfect cloning operation in the case where the loss of fidelity is less than . Therefore in this case no universal -imperfect cloning operation is possible in algebraic quantum theory.

  7. Multichanneled puzzle-like encryption

    NASA Astrophysics Data System (ADS)

    Amaya, Dafne; Tebaldi, Myrian; Torroba, Roberto; Bolognini, Néstor

    2008-07-01

    In order to increase data security transmission we propose a multichanneled puzzle-like encryption method. The basic principle relies on the input information decomposition, in the same way as the pieces of a puzzle. Each decomposed part of the input object is encrypted separately in a 4 f double random phase mask architecture, by setting the optical parameters in a determined status. Each parameter set defines a channel. In order to retrieve the whole information it is necessary to properly decrypt and compose all channels. Computer simulations that confirm our proposal are presented.

  8. Chemistry of Art and Color Sudoku Puzzles

    ERIC Educational Resources Information Center

    Welsh, Michael J.

    2007-01-01

    Sudoku puzzle format was used to teach light science and chemistry terms to students of Chemistry of Art and Color. The puzzles were used to motivate and encourage students to learn chemistry in an easier and in friendly fashion.

  9. Buckling of conical shell with local imperfections

    NASA Technical Reports Server (NTRS)

    Cooper, P. A.; Dexter, C. B.

    1974-01-01

    Small geometric imperfections in thin-walled shell structures can cause large reductions in buckling strength. Most imperfections found in structures are neither axisymmetric nor have the shape of buckling modes but rather occur locally. This report presents the results of a study of the effect of local imperfections on the critical buckling load of a specific axially compressed thin-walled conical shell. The buckling calculations were performed by using a two-dimensional shell analysis program referred to as the STAGS (Structural Analysis of General Shells) computer code, which has no axisymmetry restrictions. Results show that the buckling load found from a bifurcation buckling analysis is highly dependent on the circumferential arc length of the imperfection type studied. As the circumferential arc length of the imperfection is increased, a reduction of up to 50 percent of the critical load of the perfect shell can occur. The buckling load of the cone with an axisymmetric imperfections is nearly equal to the buckling load of imperfections which extended 60 deg or more around the circumference, but would give a highly conservative estimate of the buckling load of a shell with an imperfection of a more local nature.

  10. A Developmental Perspective on the Imperfective Paradox

    ERIC Educational Resources Information Center

    Kazanina, Nina; Phillips, Colin

    2007-01-01

    Imperfective or progressive verb morphology makes it possible to use the name of a whole event to refer to an activity that is clearly not a complete instance of that event, leading to what is known as the Imperfective Paradox. For example, a sentence like "John was building a house" does not entail that a house ever got built. The Imperfective…

  11. Methodological imperfection and formalizations in scientific activity

    SciTech Connect

    Svetlichny, G.

    1987-03-01

    Any mathematical formalization of scientific activity allows for imperfections in the methodology that is formalized. These can be of three types, dirty, rotten, and dammed. Restricting mathematical attention to those methods that cannot be construed to be imperfect drastically reduces the class of objects that must be analyzed, and related all other objects to these more regular ones. Examples are drawn from empirical logic.

  12. Package Them in Puzzles: Vocabulary, Culture, Conjugations.

    ERIC Educational Resources Information Center

    McElroy, Mary E.; Samaniego, Fabian A.

    1981-01-01

    Presents a method of using traditional puzzles and crosswords in foreign language instruction. Instead of merely providing amusement, the puzzles are designed to assist in the learning of various language skills. This article gives directions for developing puzzles specifically designed to teach grammar, vocabulary, and culture. (Author/PJM)

  13. Sudoku Puzzles as Chemistry Learning Tools

    ERIC Educational Resources Information Center

    Crute, Thomas D.; Myers, Stephanie A.

    2007-01-01

    A sudoku puzzle was designed that incorporated lists of chemistry terms like polyatomic ions, organic functional groups or strong nucleophiles that students need to learn. It was found that students enjoyed solving such puzzles and also such puzzles made the boring tasks of memorizing basic chemical terms an exciting one.

  14. Canadian Open Tennis. Puzzle Corner.

    ERIC Educational Resources Information Center

    Andrews, Ian A.

    2000-01-01

    Describes the du Maurier Open, a women's tennis tournament. Explains that tennis becomes an elite sport at the level of the du Maurier Open. Presents a crossword puzzle that focuses on many of the female tennis stars and provides the across and down clues, a word list, and the answer key. (CMK)

  15. On a Perplexing Polynomial Puzzle

    ERIC Educational Resources Information Center

    Richmond, Bettina

    2010-01-01

    It seems rather surprising that any given polynomial p(x) with nonnegative integer coefficients can be determined by just the two values p(1) and p(a), where a is any integer greater than p(1). This result has become known as the "perplexing polynomial puzzle." Here, we address the natural question of what might be required to determine a…

  16. Japanese Logic Puzzles and Proof

    ERIC Educational Resources Information Center

    Wanko, Jeffrey J.

    2009-01-01

    An understanding of proof does not start in a high school geometry course. Rather, attention to logical reasoning throughout a student's school experience can help the development of proof readiness. In the spirit of problem solving, the author has begun to use some Japanese logic puzzles other than sudoku to help students develop additional…

  17. Making Peer-Assisted Content Distribution Robust to Collusion Using Bandwidth Puzzles

    NASA Astrophysics Data System (ADS)

    Reiter, Michael K.; Sekar, Vyas; Spensky, Chad; Zhang, Zhenghao

    Many peer-assisted content-distribution systems reward a peer based on the amount of data that this peer serves to others. However, validating that a peer did so is, to our knowledge, an open problem; e.g., a group of colluding attackers can earn rewards by claiming to have served content to one another, when they have not. We propose a puzzle mechanism to make contribution-aware peer-assisted content distribution robust to such collusion. Our construction ties solving the puzzle to possession of specific content and, by issuing puzzle challenges simultaneously to all parties claiming to have that content, our mechanism prevents one content-holder from solving many others' puzzles. We prove (in the random oracle model) the security of our scheme, describe our integration of bandwidth puzzles into a media streaming system, and demonstrate the resulting attack resilience via simulations.

  18. Constrained Clustering With Imperfect Oracles.

    PubMed

    Zhu, Xiatian; Loy, Chen Change; Gong, Shaogang

    2016-06-01

    While clustering is usually an unsupervised operation, there are circumstances where we have access to prior belief that pairs of samples should (or should not) be assigned with the same cluster. Constrained clustering aims to exploit this prior belief as constraint (or weak supervision) to influence the cluster formation so as to obtain a data structure more closely resembling human perception. Two important issues remain open: 1) how to exploit sparse constraints effectively and 2) how to handle ill-conditioned/noisy constraints generated by imperfect oracles. In this paper, we present a novel pairwise similarity measure framework to address the above issues. Specifically, in contrast to existing constrained clustering approaches that blindly rely on all features for constraint propagation, our approach searches for neighborhoods driven by discriminative feature selection for more effective constraint diffusion. Crucially, we formulate a novel approach to handling the noisy constraint problem, which has been unrealistically ignored in the constrained clustering literature. Extensive comparative results show that our method is superior to the state-of-the-art constrained clustering approaches and can generally benefit existing pairwise similarity-based data clustering algorithms, such as spectral clustering and affinity propagation. PMID:25622327

  19. Current puzzles and future possibilities

    SciTech Connect

    Nagamiya, S.

    1982-02-01

    Four current puzzles and several future experimental possibilities in high-energy nuclear collision research are discussed. These puzzles are (1) entropy, (2) hydrodynamic flow, (3) anomalon, and (4) particle emission at backward angles in proton-nucleus collisions. The last one seems not to be directly related to the subject of the present school. But it is, because particle emission into the region far beyond the nucleon-nucleon kinematical limit is an interesting subject common for both proton-nucleus and nucleus-nucleus collisions, and the basic mechanism involved is strongly related in these two cases. Future experimental possibilities are described which include: (1) possibilities of studying multibaryonic excited states, (2) applications of neutron-rich isotopes, and (3) other needed experimental tasks. 72 references.

  20. Teaching Imperfect Competition at the Principles Level.

    ERIC Educational Resources Information Center

    Weber, William V.; Highfill, Jannett K.

    1990-01-01

    Argues that, although most economics textbooks' explanations of imperfect competition may involve three to five models, the concept can be taught using a single, simple model. Uses several business/economic examples as illustrations. (DB)

  1. Understanding Your Vision: The "Imperfect Eye"

    MedlinePlus

    ... Navigation Bar Home Current Issue Past Issues Feature: Vision Understanding Your Vision: The "Imperfect Eye" Past Issues / Summer 2008 Table ... are different and so are the types of vision that we have. Understanding how some of us ...

  2. Construction-Paper Puzzle Masterpieces

    ERIC Educational Resources Information Center

    Vance, Shelly

    2010-01-01

    Creating an appreciation of art history in her junior-high students has always been one of the author's greatest challenges as an art teacher. In this article, the author describes how her eighth-grade students re-created a famous work of art--piece by piece, like a puzzle or a stained-glass window--out of construction paper. (Contains 1 resource.)

  3. Methodological Imperfection and Formalizations of Scientific Activity

    NASA Astrophysics Data System (ADS)

    Svetlichny, George

    1987-03-01

    Any mathematical formalization of scientific activity allows for imperfections in the methodology that is formalized. These can be of three types, “dirty,” “rotten,” and “dammed.” Restricting mathematical attention to those methods that cannot be construed to be imperfect drastically reduces the class of objects that must be analyzed, and relates all other objects to these more regular ones. Examples are drawn from empirical logic.

  4. Knowledge.

    ERIC Educational Resources Information Center

    Online-Offline, 1999

    1999-01-01

    This theme issue on knowledge includes annotated listings of Web sites, CD-ROMs and computer software, videos, books, and additional resources that deal with knowledge and differences between how animals and humans learn. Sidebars discuss animal intelligence, learning proper behavior, and getting news from the Internet. (LRW)

  5. Economics - A Puzzle: The People Power Solution.

    ERIC Educational Resources Information Center

    Bartlett, Glenda; Price, Marlene H.

    A third-grade class and fifth-grade remedial reading students gained a positive attitude toward contemporary economic problems by studying economics as a puzzle in this award-winning project. The following concepts were each approached as pieces of the puzzle to be solved: money, wants and needs, income, goods and services, scarcity, consumption…

  6. Guerrilla Puzzling: A Model for Research

    ERIC Educational Resources Information Center

    Zimmer, Marc

    2007-01-01

    There are two main settings for puzzle solving in higher education: graduate programs, with professors and both graduate and postdoctoral students; and predominantly undergraduate institutions, with professors and students. Research programs at large universities are well-oiled puzzle-solving machines. Graduate students there work long, hard hours…

  7. Advocacy: AASL Puts the Puzzle Together

    ERIC Educational Resources Information Center

    Johns, Sara Kelly

    2007-01-01

    School librarians work with people of all ages, abilities, and personalities; those people are the puzzle pieces that make advocacy for libraries effective. School librarians contribute to and use the resources of their state and national organizations' advocacy efforts. The completed picture of the puzzle is an excellent program with…

  8. Project-A-Puzzle. Second Edition.

    ERIC Educational Resources Information Center

    Porter, Richard D.

    This set of transparency masters of mathematical puzzles has as its intent the development of logical and perceptual skills. The puzzles include patterns, magic squares, and counting problems. Solutions and follow-up suggestions are provided on the back of each page. (MP)

  9. Solving the BM Camelopardalis puzzle

    NASA Technical Reports Server (NTRS)

    Teke, Mathias; Busby, Michael R.; Hall, Douglas S.

    1989-01-01

    BM Camelopardalis (=12 Cam) is a chromospherically active binary star with a relatively large orbital eccentricity. Systems with large eccentricities usually rotate pseudosynchronously. However, BM Cam has been a puzzle since its observed rotation rate is virtually equal to its orbital period indicating synchronization. All available photometry data for BM Cam have been collected and analyzed. Two models of modulated ellipticity effect are proposed, one based on equilibrium tidal deformation of the primary star and the other on a dynamical tidal effect. When the starspot variability is removed from the data, the dynamical tidal model was the better approximation to the real physical situation. The analysis indicates that BM Cam is not rotating pseudosynchronously but rotating in virtual synchronism after all.

  10. Solving combinatorial problems: the 15-puzzle.

    PubMed

    Pizlo, Zygmunt; Li, Zheng

    2005-09-01

    We present a series of experiments in which human subjects were tested with a well-known combinatorial problem called the 15-puzzle and in different-sized variants of this puzzle. Subjects can solve these puzzles reliably by systematically building a solution path, without performing much search and without using distances among the states of the problem. The computational complexity of the underlying mental mechanisms is very low. We formulated a computational model of the underlying cognitive processes on the basis of our results. This model applied a pyramid algorithm to individual stages of each problem. The model's performance proved to be quite similar to the subjects' performance. PMID:16496727

  11. Imperfect chimera states for coupled pendula.

    PubMed

    Kapitaniak, Tomasz; Kuzma, Patrycja; Wojewoda, Jerzy; Czolczynski, Krzysztof; Maistrenko, Yuri

    2014-01-01

    The phenomenon of chimera states in the systems of coupled, identical oscillators has attracted a great deal of recent theoretical and experimental interest. In such a state, different groups of oscillators can exhibit coexisting synchronous and incoherent behaviors despite homogeneous coupling. Here, considering the coupled pendula, we find another pattern, the so-called imperfect chimera state, which is characterized by a certain number of oscillators which escape from the synchronized chimera's cluster or behave differently than most of uncorrelated pendula. The escaped elements oscillate with different average frequencies (Poincare rotation number). We show that imperfect chimera can be realized in simple experiments with mechanical oscillators, namely Huygens clock. The mathematical model of our experiment shows that the observed chimera states are controlled by elementary dynamical equations derived from Newton's laws that are ubiquitous in many physical and engineering systems. PMID:25223296

  12. Impact of imperfect information on network attack

    NASA Astrophysics Data System (ADS)

    Melchionna, Andrew; Caloca, Jesus; Squires, Shane; Antonsen, Thomas M.; Ott, Edward; Girvan, Michelle

    2015-03-01

    This paper explores the effectiveness of network attack when the attacker has imperfect information about the network. For Erdős-Rényi networks, we observe that dynamical importance and betweenness centrality-based attacks are surprisingly robust to the presence of a moderate amount of imperfect information and are more effective compared with simpler degree-based attacks even at moderate levels of network information error. In contrast, for scale-free networks the effectiveness of attack is much less degraded by a moderate level of information error. Furthermore, in the Erdős-Rényi case the effectiveness of network attack is much more degraded by missing links as compared with the same number of false links.

  13. Impact of imperfect information on network attack.

    PubMed

    Melchionna, Andrew; Caloca, Jesus; Squires, Shane; Antonsen, Thomas M; Ott, Edward; Girvan, Michelle

    2015-03-01

    This paper explores the effectiveness of network attack when the attacker has imperfect information about the network. For Erdős-Rényi networks, we observe that dynamical importance and betweenness centrality-based attacks are surprisingly robust to the presence of a moderate amount of imperfect information and are more effective compared with simpler degree-based attacks even at moderate levels of network information error. In contrast, for scale-free networks the effectiveness of attack is much less degraded by a moderate level of information error. Furthermore, in the Erdős-Rényi case the effectiveness of network attack is much more degraded by missing links as compared with the same number of false links. PMID:25871157

  14. Quantum metrology with imperfect states and detectors

    SciTech Connect

    Datta, Animesh; Zhang Lijian; Thomas-Peter, Nicholas; Smith, Brian J.; Walmsley, Ian A.; Dorner, Uwe

    2011-06-15

    Quantum enhancements of precision in metrology can be compromised by system imperfections. These may be mitigated by appropriate optimization of the input state to render it robust, at the expense of making the state difficult to prepare. In this paper, we identify the major sources of imperfection of an optical sensor: input state preparation inefficiency, sensor losses, and detector inefficiency. The second of these has received much attention; we show that it is the least damaging to surpassing the standard quantum limit in a optical interferometric sensor. Further, we show that photonic states that can be prepared in the laboratory using feasible resources allow a measurement strategy using photon-number-resolving detectors that not only attain the Heisenberg limit for phase estimation in the absence of losses, but also deliver close to the maximum possible precision in realistic scenarios including losses and inefficiencies. In particular, we give bounds for the tradeoff between the three sources of imperfection that will allow true quantum-enhanced optical metrology

  15. Polarization puzzles for the upper elementary grades

    NASA Astrophysics Data System (ADS)

    Chandrasekhar, Meera; Rainwater, David L.; Litherland, Rebecca Q.; Swope, Rodney A.; VanNest, Ann

    1995-10-01

    The concept of polarization and its most basic consequence, Malus' Law, is usually not taught in the elementary or middle grades because of conceptual difficulties. We introduce the concept of polarization using sunglasses to understand the consequences of parallel and crossed polarizers. We then expand the concept with four puzzles. The puzzles are cut out of sheets of linear polarizers and are viewed through a (hand held) spinning polarizer. The first puzzle is constructed out of wedge shaped pieces of linear polarizer so that the wheel appears to rotate when viewed through the spinning polarizer. The second puzzle consists of concentric circles that appear to radiate outward. The third and fourth puzzles are four- and twelve piece wedges that are manipulated to produce different symmetric designs. We have tested these activities on fifth and sixth graders, and find that they enjoy the manipulative as well as the problem solving aspects of the puzzles. They are also able to understand that when light is polarized, 'whatever it is that waves' (the electric field) is oriented in one direction. The materials are inexpensive and can be easily made by teachers for classroom learning.

  16. Shell Buckling Design Criteria Based on Manufacturing Imperfection Signatures

    NASA Technical Reports Server (NTRS)

    Hilburger, Mark W.; Nemeth, Michael P.; Starnes, James H., Jr.

    2004-01-01

    An analysis-based approach .for developing shell-buckling design criteria for laminated-composite cylindrical shells that accurately accounts for the effects of initial geometric imperfections is presented. With this approach, measured initial geometric imperfection data from six graphite-epoxy shells are used to determine a manufacturing-process-specific imperfection signature for these shells. This imperfection signature is then used as input into nonlinear finite-element analyses. The imperfection signature represents a "first-approximation" mean imperfection shape that is suitable for developing preliminary-design data. Comparisons of test data and analytical results obtained by using several different imperfection shapes are presented for selected shells. Overall, the results indicate that the analysis-based approach presented for developing reliable preliminary-design criteria has the potential to provide improved, less conservative buckling-load estimates, and to reduce the weight and cost of developing buckling-resistant shell structures.

  17. Tornillos: Pieces of a Puzzle

    NASA Astrophysics Data System (ADS)

    Hellweg, M.; Seidl, D.

    2001-12-01

    In the past decade several of the ash eruptions at Galeras volcano (Colombia) have been preceded by tornillos. These unusual seismic events of unknown origin have screw-like profiles on seismograms and can last up to several minutes. Since 1997, a joint project between the Bundesanstalt für Geowissenschaften und Rohstoffe (BGR) and the Instituto de Investigación e Información Geocientífica, Minero-Ambiental y Nuclear (INGEOMINAS) has supplemented the shortperiod network of the Observatorio Vulcanológico de Pasto with four broadband, three-component seismometer stations, continuous fumarole gas chemistry measurments, electromagnetic sensors, an infrasound sensor and weather observations in the hopes to learn more about the physical or chemical process which generates tornillos and their significance in the sequence leading to ash explosions. The events of a suite of tornillos which occurred at Galeras Volcano between 08 December 1999 and 11 February 2000 were recorded well at the crater rim broadband stations, ANG and ACH. They appear to be more complex than many of the tornillos recorded previously. They are multichromatic, having narrow spectral peaks at up to 9 frequencies. Some peaks last throughout the entire tornillo, others only contribute to the turn-on transient. We compare polarization, frequency, amplitudes and decay measured from this suite of tornillos in each frequency band at the stations ANG and ACH. They indicate a single source location for all these tornillos. While other parameters correlate well at both stations, the amplitude of the 1.9 Hz peak is nearly twice as large at ACH than at ANG. This may indicate a distinct radiation pattern at this frequency. While none of these observations gives us a clear picture of the source process of tornillos, they provide additional puzzle pieces we can add those collected from other measurements.

  18. Imperfect relativistic mirrors in the quantum regime

    SciTech Connect

    Mendonça, J. T.; Serbeto, A.; Galvão, R. M. O.

    2014-05-15

    The collective backscattering of intense laser radiation by energetic electron beams is considered in the relativistic quantum regime. Exact solutions for the radiation field are obtained, for arbitrary electron pulse shapes and laser intensities. The electron beams act as imperfect nonlinear mirrors on the incident laser radiation. This collective backscattering process can lead to the development of new sources of ultra-short pulse radiation in the gamma-ray domain. Numerical examples show that, for plausible experimental conditions, intense pulses of gamma-rays, due to the double Doppler shift of the harmonics of the incident laser radiation, can be produced using the available technology, with durations less than 1 as.

  19. Imperfection, practice and humility in clinical ethics.

    PubMed

    Garchar, Kim

    2012-10-01

    In this essay, I provide a description of the discipline of ethics using the philosophies of Aristotle and the American pragmatist John Dewey. Specifically, I argue that ethics is an active undertaking that is ambiguous and pluralistic. I then normatively prescribe the way in which clinical ethicists ought to approach their work in medicine. Rather than endeavouring to become, or behaving as if they are, experts, clinical ethicists must be humble. They must practise ethics. That is, they must admit ethics is the study and pursuit of the good life but that this study and pursuit occurs imperfectly in the face of problematic situations. PMID:22995007

  20. Chaos in an imperfectly premixed model combustor.

    PubMed

    Kabiraj, Lipika; Saurabh, Aditya; Karimi, Nader; Sailor, Anna; Mastorakos, Epaminondas; Dowling, Ann P; Paschereit, Christian O

    2015-02-01

    This article reports nonlinear bifurcations observed in a laboratory scale, turbulent combustor operating under imperfectly premixed mode with global equivalence ratio as the control parameter. The results indicate that the dynamics of thermoacoustic instability correspond to quasi-periodic bifurcation to low-dimensional, deterministic chaos, a route that is common to a variety of dissipative nonlinear systems. The results support the recent identification of bifurcation scenarios in a laminar premixed flame combustor (Kabiraj et al., Chaos: Interdiscip. J. Nonlinear Sci. 22, 023129 (2012)) and extend the observation to a practically relevant combustor configuration. PMID:25725637

  1. Chaos in an imperfectly premixed model combustor

    SciTech Connect

    Kabiraj, Lipika Saurabh, Aditya; Paschereit, Christian O.; Karimi, Nader; Sailor, Anna; Mastorakos, Epaminondas; Dowling, Ann P.

    2015-02-15

    This article reports nonlinear bifurcations observed in a laboratory scale, turbulent combustor operating under imperfectly premixed mode with global equivalence ratio as the control parameter. The results indicate that the dynamics of thermoacoustic instability correspond to quasi-periodic bifurcation to low-dimensional, deterministic chaos, a route that is common to a variety of dissipative nonlinear systems. The results support the recent identification of bifurcation scenarios in a laminar premixed flame combustor (Kabiraj et al., Chaos: Interdiscip. J. Nonlinear Sci. 22, 023129 (2012)) and extend the observation to a practically relevant combustor configuration.

  2. Method for correcting imperfections on a surface

    SciTech Connect

    Sweatt, William C.; Weed, John W.

    1999-09-07

    A process for producing near perfect optical surfaces. A previously polished optical surface is measured to determine its deviations from the desired perfect surface. A multi-aperture mask is designed based on this measurement and fabricated such that deposition through the mask will correct the deviations in the surface to an acceptable level. Various mask geometries can be used: variable individual aperture sizes using a fixed grid for the apertures or fixed aperture sizes using a variable aperture spacing. The imperfections are filled in using a vacuum deposition process with a very thin thickness of material such as silicon monoxide to produce an amorphous surface that bonds well to a glass substrate.

  3. Imperfect twinning: a clinical and ethical dilemma

    PubMed Central

    Denardin, Daniela; Telles, Jorge Alberto B.; Betat, Rosilene da Silveira; Fell, Paulo Renato K.; da Cunha, André Campos; Targa, Luciano Vieira; Zen, Paulo Ricardo G.; Rosa, Rafael Fabiano M.

    2013-01-01

    OBJECTIVE To review the history, epidemiology, etiology, gestational aspects, diagnosis and prognosis of imperfect twinning. DATA SOURCES Scientific articles were searched in PubMed, SciELO and Lilacs databases, using the descriptors "conjoined twins", "multiple pregnancy", "ultrasound", "magnetic resonance imaging" and "prognosis". The research was not delimited to a specific period of time and was supplemented with bibliographic data from books. DATA SYNTHESIS: The description of conjoined twins is legendary. The estimated frequency is 1/45,000-200,000 births. These twins are monozygotic, monochorionic and usually monoamniotic. They can be classified by the most prominent fusion site, by the symmetry between the conjoined twins or by the sharing structure. The diagnosis can be performed in the prenatal period or after birth by different techniques, such as ultrasound, magnetic resonance imaging and echocardiography. These tests are of paramount importance for understanding the anatomy of both fetuses/children, as well as for prognosis and surgical plan determination. CONCLUSIONS Although imperfect twinning is a rare condition, the prenatal diagnosis is very important in order to evaluate the fusion site and its complexity. Hence, the evaluation of these children should be multidisciplinary, involving mainly obstetricians, pediatricians and pediatric surgeons. However, some decisions may constitute real ethical dilemmas, in which different points should be discussed and analyzed with the health team and the family. PMID:24142323

  4. Statistical analysis of imperfection effect on cylindrical buckling response

    NASA Astrophysics Data System (ADS)

    Ismail, M. S.; Purbolaksono, J.; Muhammad, N.; Andriyana, A.; Liew, H. L.

    2015-12-01

    It is widely reported that no efficient guidelines for modelling imperfections in composite structures are available. In response, this work evaluates the imperfection factors of axially compressed Carbon Fibre Reinforced Polymer (CFRP) cylinder with different ply angles through finite element (FE) analysis. The sensitivity of imperfection factors were analysed using design of experiment: factorial design approach. From the analysis it identified three critical factors that sensitively reacted towards buckling load. Furthermore empirical equation is proposed according to each type of cylinder. Eventually, critical buckling loads estimated by empirical equation showed good agreements with FE analysis. The design of experiment methodology is useful in identifying parameters that lead to structures imperfection tolerance.

  5. Bullet-Block Science Video Puzzle

    ERIC Educational Resources Information Center

    Shakur, Asif

    2015-01-01

    A science video blog, which has gone viral, shows a wooden block shot by a vertically aimed rifle. The video shows that the block hit dead center goes exactly as high as the one shot off-center. (Fig. 1). The puzzle is that the block shot off-center carries rotational kinetic energy in addition to the gravitational potential energy. This leads a…

  6. Ramanujan's Continued Fraction for a Puzzle

    ERIC Educational Resources Information Center

    Park, Poo-Sung

    2005-01-01

    This article describes a method of solution that Ramanujan may have used in solving the following puzzle: The number of a house is both the sum of the house numbers below it on the street and the sum of those above it. (The houses on a street are numbered consecutively, starting with 1.)

  7. Insights and Puzzles in Particle Physics

    NASA Astrophysics Data System (ADS)

    Leutwyler, H.

    2015-03-01

    I briefly review the conceptual developments that led to the Standard Model and discuss some of its remarkable qualitative features. On the way, I draw attention to several puzzling aspects that are beyond the reach of our present understanding of the basic laws of physics.

  8. Insights and puzzles in particle physics

    NASA Astrophysics Data System (ADS)

    Leutwyler, H.

    2015-01-01

    I briefly review the conceptual developments that led to the Standard Model and discuss some of its remarkable qualitative features. On the way, I draw attention to several puzzling aspects that are beyond the reach of our present understanding of the basic laws of physics.

  9. Exploring Organic Mechanistic Puzzles with Molecular Modeling

    ERIC Educational Resources Information Center

    Horowitz, Gail; Schwartz, Gary

    2004-01-01

    The molecular modeling was used to reinforce more general skills such as deducing and drawing reaction mechanisms, analyzing reaction kinetics and thermodynamics and drawing reaction coordinate energy diagrams. This modeling was done through the design of mechanistic puzzles, involving reactions not familiar to the students.

  10. Reinforcing Geometric Properties with Shapedoku Puzzles

    ERIC Educational Resources Information Center

    Wanko, Jeffrey J.; Nickell, Jennifer V.

    2013-01-01

    Shapedoku is a new type of puzzle that combines logic and spatial reasoning with understanding of basic geometric concepts such as slope, parallelism, perpendicularity, and properties of shapes. Shapedoku can be solved by individuals and, as demonstrated here, can form the basis of a review for geometry students as they create their own. In this…

  11. Mathematical History: Activities, Puzzles, Stories, and Games.

    ERIC Educational Resources Information Center

    Mitchell, Merle

    Based on the history of mathematics, these materials have been planned to enrich the teaching of mathematics in grades four, five, and six. Puzzles and games are based on stories about topics such as famous mathematicians, numerals of ancient peoples, and numerology. The sheets are arranged by grade level and are designed for easy duplication.…

  12. Method for correcting imperfections on a surface

    SciTech Connect

    Sweatt, W.C.; Weed, J.W.

    1999-09-07

    A process for producing near perfect optical surfaces is disclosed. A previously polished optical surface is measured to determine its deviations from the desired perfect surface. A multi-aperture mask is designed based on this measurement and fabricated such that deposition through the mask will correct the deviations in the surface to an acceptable level. Various mask geometries can be used: variable individual aperture sizes using a fixed grid for the apertures or fixed aperture sizes using a variable aperture spacing. The imperfections are filled in using a vacuum deposition process with a very thin thickness of material such as silicon monoxide to produce an amorphous surface that bonds well to a glass substrate.

  13. Weird Stellar Pair Puzzles Scientists

    NASA Astrophysics Data System (ADS)

    2008-05-01

    Astronomers have discovered a speedy spinning pulsar in an elongated orbit around an apparent Sun-like star, a combination never seen before, and one that has them puzzled about how the strange system developed. Orbital Comparison Comparing Orbits of Pulsar and Its Companion to our Solar System. CREDIT: Bill Saxton, NRAO/AUI/NSF Click on image for full caption information and available graphics. "Our ideas about how the fastest-spinning pulsars are produced do not predict either the kind of orbit or the type of companion star this one has," said David Champion of the Australia Telescope National Facility. "We have to come up with some new scenarios to explain this weird pair," he added. Astronomers first detected the pulsar, called J1903+0327, as part of a long-term survey using the National Science Foundation's Arecibo radio telescope in Puerto Rico. They made the discovery in 2006 doing data analysis at McGill University, where Champion worked at the time. They followed up the discovery with detailed studies using the Arecibo telescope, the NSF's Robert C. Byrd Green Bank Telescope (GBT) in West Virginia, the Westerbork radio telescope in the Netherlands, and the Gemini North optical telescope in Hawaii. The pulsar, a city-sized superdense stellar corpse left over after a massive star exploded as a supernova, is spinning on its axis 465 times every second. Nearly 21,000 light-years from Earth, it is in a highly-elongated orbit that takes it around its companion star once every 95 days. An infrared image made with the Gemini North telescope in Hawaii shows a Sun-like star at the pulsar's position. If this is an orbital companion to the pulsar, it is unlike any companions of other rapidly rotating pulsars. The pulsar, a neutron star, also is unusually massive for its type. "This combination of properties is unprecedented. Not only does it require us to figure out how this system was produced, but the large mass may help us understand how matter behaves at extremely

  14. Imperfection sensitivity of pressured buckling of biopolymer spherical shells

    NASA Astrophysics Data System (ADS)

    Zhang, Lei; Ru, C. Q.

    2016-06-01

    Imperfection sensitivity is essential for mechanical behavior of biopolymer shells [such as ultrasound contrast agents (UCAs) and spherical viruses] characterized by high geometric heterogeneity. In this work, an imperfection sensitivity analysis is conducted based on a refined shell model recently developed for spherical biopolymer shells of high structural heterogeneity and thickness nonuniformity. The influence of related parameters (including the ratio of radius to average shell thickness, the ratio of transverse shear modulus to in-plane shear modulus, and the ratio of effective bending thickness to average shell thickness) on imperfection sensitivity is examined for pressured buckling. Our results show that the ratio of effective bending thickness to average shell thickness has a major effect on the imperfection sensitivity, while the effect of the ratio of transverse shear modulus to in-plane shear modulus is usually negligible. For example, with physically realistic parameters for typical imperfect spherical biopolymer shells, the present model predicts that actual maximum external pressure could be reduced to as low as 60% of that of a perfect UCA spherical shell or 55%-65% of that of a perfect spherical virus shell, respectively. The moderate imperfection sensitivity of spherical biopolymer shells with physically realistic imperfection is largely attributed to the fact that biopolymer shells are relatively thicker (defined by smaller radius-to-thickness ratio) and therefore practically realistic imperfection amplitude normalized by thickness is very small as compared to that of classical elastic thin shells which have much larger radius-to-thickness ratio.

  15. Puzzles in hyperon, charm and beauty physics.

    SciTech Connect

    Lipkin, H. J.

    2002-10-21

    Puzzles awaiting better experiments and better theory include: (1) the contradiction between good and bad SU(3) baryon wave functions in fitting Cabibbo theory for hyperon decays, strangeness suppression in the sea and the violation of the Gottfried Sum rule--no model fits all; (2) Anomalously enhanced Cabibbo-suppressed D{sup +} {yields} K*{sup +} (s{bar d}) decays; (3) anomalously enhanced and suppressed B {yields} {eta}{prime} X decays; (4) the OZI rule in weak decays; (5) Vector dominance (W {yields} {pi}, {rho}, a{sub 1}, D{sub s}, D*{sub s}) in weak decays; (6) puzzles in doubly-cabibbo-suppressed charm decays; and (7) problems in obtaining {Lambda} spin structure from polarization measurements of produced {Lambda}'s.

  16. Use of Imperfect Calibration for Seismic Location

    SciTech Connect

    Myers, S C; Schultz, C A

    2000-07-12

    Efforts to more effectively monitor nuclear explosions include the calibration of travel times along specific paths. Benchmark events are used to improve travel-time prediction by (1) improving models, (2) determining travel times empirically, or (3) using a hybrid approach. Even velocity models that are determined using geophysical analogy (i.e. models determined without the direct use of calibration data) require validation with calibration events. Ideally, the locations and origin times of calibration events would be perfectly known. However, the existing set of perfectly known events is spatially limited and many of these events occurred prior to the installation of current monitoring stations, thus limiting their usefulness. There are, however, large numbers of well (but not perfectly) located events that are spatially distributed, and many of these events may be used for calibration. Identifying the utility and limitations of the spatially distributed set of imperfect calibration data is of paramount importance to the calibration effort. In order to develop guidelines for calibration utility, we examine the uncertainty and correlation of location parameters under several network configurations that are commonly used to produce calibration-grade locations. We then map these calibration uncertainties through location procedures with network configurations that are likely in monitoring situations. By examining the ramifications of depth and origin-time uncertainty, we expand on previous studies that focus strictly on epicenter accuracy. Particular attention is given to examples where calibration events are determined with teleseismic or local networks and monitoring is accomplished with a regional network.

  17. Influence of imperfections on effective properties of cellular solids

    SciTech Connect

    Grenestedt, J.L.

    1998-12-31

    The mechanical properties of cellular solids, or solid foams, is affected by imperfections such as wavy distortions of cell walls, variations in cell wall thickness, non-uniform cell shape, etc. The present paper is focused mainly on elastic stiffnesses of closed cell cellular solids. A perfect model is first discussed and shown to predict the behavior of PVC foams well. However, this model over-estimates the stiffnesses of aluminum foams. The relatively poor properties of the aluminum foam are believed to be caused by imperfections in the cells. The main body of the paper focuses on modeling different kinds of imperfections, and analyzing their impact on foam properties.

  18. Bayesian imperfect information analysis for clinical recurrent data

    PubMed Central

    Chang, Chih-Kuang; Chang, Chi-Chang

    2015-01-01

    In medical research, clinical practice must often be undertaken with imperfect information from limited resources. This study applied Bayesian imperfect information-value analysis to realistic situations to produce likelihood functions and posterior distributions, to a clinical decision-making problem for recurrent events. In this study, three kinds of failure models are considered, and our methods illustrated with an analysis of imperfect information from a trial of immunotherapy in the treatment of chronic granulomatous disease. In addition, we present evidence toward a better understanding of the differing behaviors along with concomitant variables. Based on the results of simulations, the imperfect information value of the concomitant variables was evaluated and different realistic situations were compared to see which could yield more accurate results for medical decision-making. PMID:25565853

  19. Buckling Imperfection Sensitivity of Axially Compressed Orthotropic Cylinders

    NASA Technical Reports Server (NTRS)

    Schultz, Marc R.; Nemeth, Michael P.

    2010-01-01

    Structural stability is a major consideration in the design of lightweight shell structures. However, the theoretical predictions of geometrically perfect structures often considerably over predict the buckling loads of inherently imperfect real structures. It is reasonably well understood how the shell geometry affects the imperfection sensitivity of axially compressed cylindrical shells; however, the effects of shell anisotropy on the imperfection sensitivity is less well understood. In the present paper, the development of an analytical model for assessing the imperfection sensitivity of axially compressed orthotropic cylinders is discussed. Results from the analytical model for four shell designs are compared with those from a general-purpose finite-element code, and good qualitative agreement is found. Reasons for discrepancies are discussed, and potential design implications of this line of research are discussed.

  20. Quantification of the Forgiveness of Drugs to Imperfect Adherence.

    PubMed

    Assawasuwannakit, P; Braund, R; Duffull, S B

    2015-03-01

    The circumstance of how sensitive therapeutic success is under imperfect adherence is driven by the property known as forgiveness. To date, no studies have considered variability in the pharmacokinetic-pharmacodynamic process in conjunction with imperfect adherence patterns in order to develop a comparative criterion to determine the forgiveness of a drug. In this study, we have proposed a criterion to quantify forgiveness; illustrated the criterion for a theoretical example and evaluated the forgiveness of a motivating example, namely warfarin. A forgiveness criterion, relative forgiveness, is defined as the number of times more likely that a target is successfully attained under perfect adherence compared to imperfect adherence; or when comparing two drugs under a standard setting of imperfect adherence. The relative forgiveness criterion may have important implications for both drug development and clinical practice since the choice of drug can account for the likely influence of its forgiveness. PMID:26225235

  1. Macromolecular diffractive imaging using imperfect crystals.

    PubMed

    Ayyer, Kartik; Yefanov, Oleksandr M; Oberthür, Dominik; Roy-Chowdhury, Shatabdi; Galli, Lorenzo; Mariani, Valerio; Basu, Shibom; Coe, Jesse; Conrad, Chelsie E; Fromme, Raimund; Schaffer, Alexander; Dörner, Katerina; James, Daniel; Kupitz, Christopher; Metz, Markus; Nelson, Garrett; Xavier, Paulraj Lourdu; Beyerlein, Kenneth R; Schmidt, Marius; Sarrou, Iosifina; Spence, John C H; Weierstall, Uwe; White, Thomas A; Yang, Jay-How; Zhao, Yun; Liang, Mengning; Aquila, Andrew; Hunter, Mark S; Robinson, Joseph S; Koglin, Jason E; Boutet, Sébastien; Fromme, Petra; Barty, Anton; Chapman, Henry N

    2016-02-11

    The three-dimensional structures of macromolecules and their complexes are mainly elucidated by X-ray protein crystallography. A major limitation of this method is access to high-quality crystals, which is necessary to ensure X-ray diffraction extends to sufficiently large scattering angles and hence yields information of sufficiently high resolution with which to solve the crystal structure. The observation that crystals with reduced unit-cell volumes and tighter macromolecular packing often produce higher-resolution Bragg peaks suggests that crystallographic resolution for some macromolecules may be limited not by their heterogeneity, but by a deviation of strict positional ordering of the crystalline lattice. Such displacements of molecules from the ideal lattice give rise to a continuous diffraction pattern that is equal to the incoherent sum of diffraction from rigid individual molecular complexes aligned along several discrete crystallographic orientations and that, consequently, contains more information than Bragg peaks alone. Although such continuous diffraction patterns have long been observed--and are of interest as a source of information about the dynamics of proteins--they have not been used for structure determination. Here we show for crystals of the integral membrane protein complex photosystem II that lattice disorder increases the information content and the resolution of the diffraction pattern well beyond the 4.5-ångström limit of measurable Bragg peaks, which allows us to phase the pattern directly. Using the molecular envelope conventionally determined at 4.5 ångströms as a constraint, we obtain a static image of the photosystem II dimer at a resolution of 3.5 ångströms. This result shows that continuous diffraction can be used to overcome what have long been supposed to be the resolution limits of macromolecular crystallography, using a method that exploits commonly encountered imperfect crystals and enables model-free phasing. PMID

  2. Macromolecular diffractive imaging using imperfect crystals

    PubMed Central

    Ayyer, Kartik; Yefanov, Oleksandr; Oberthür, Dominik; Roy-Chowdhury, Shatabdi; Galli, Lorenzo; Mariani, Valerio; Basu, Shibom; Coe, Jesse; Conrad, Chelsie E.; Fromme, Raimund; Schaffer, Alexander; Dörner, Katerina; James, Daniel; Kupitz, Christopher; Metz, Markus; Nelson, Garrett; Lourdu Xavier, Paulraj; Beyerlein, Kenneth R.; Schmidt, Marius; Sarrou, Iosifina; Spence, John C. H.; Weierstall, Uwe; White, Thomas A.; Yang, Jay-How; Zhao, Yun; Liang, Mengning; Aquila, Andrew; Hunter, Mark S.; Robinson, Joseph S.; Koglin, Jason E.; Boutet, Sébastien; Fromme, Petra; Barty, Anton; Chapman, Henry N.

    2016-01-01

    The three-dimensional structures of macromolecules and their complexes are predominantly elucidated by X-ray protein crystallography. A major limitation is access to high-quality crystals, to ensure X-ray diffraction extends to sufficiently large scattering angles and hence yields sufficiently high-resolution information that the crystal structure can be solved. The observation that crystals with shrunken unit-cell volumes and tighter macromolecular packing often produce higher-resolution Bragg peaks1,2 hints that crystallographic resolution for some macromolecules may be limited not by their heterogeneity but rather by a deviation of strict positional ordering of the crystalline lattice. Such displacements of molecules from the ideal lattice give rise to a continuous diffraction pattern, equal to the incoherent sum of diffraction from rigid single molecular complexes aligned along several discrete crystallographic orientations and hence with an increased information content3. Although such continuous diffraction patterns have long been observed—and are of interest as a source of information about the dynamics of proteins4 —they have not been used for structure determination. Here we show for crystals of the integral membrane protein complex photosystem II that lattice disorder increases the information content and the resolution of the diffraction pattern well beyond the 4.5 Å limit of measurable Bragg peaks, which allows us to directly phase5 the pattern. With the molecular envelope conventionally determined at 4.5 Å as a constraint, we then obtain a static image of the photosystem II dimer at 3.5 Å resolution. This result shows that continuous diffraction can be used to overcome long-supposed resolution limits of macromolecular crystallography, with a method that puts great value in commonly encountered imperfect crystals and opens up the possibility for model-free phasing6,7. PMID:26863980

  3. Precision Astronomy with Imperfect Deep Depletion CCDs

    NASA Astrophysics Data System (ADS)

    Stubbs, Christopher; LSST Sensor Team; PanSTARRS Team

    2014-01-01

    While thick CCDs do provide definite advantages in terms of increased quantum efficiency at wavelengths 700 nm<λ < 1.1 microns and reduced fringing from atmospheric emission lines, these devices also exhibit undesirable features that pose a challenge to precision determination of the positions, fluxes, and shapes of astronomical objects, and for the precision extraction of features in astronomical spectra. For example, the assumptions of a perfectly rectilinear pixel grid and of an intensity-independent point spread function become increasingly invalid as we push to higher precision measurements. Many of the effects seen in these devices arise from lateral electrical fields within the detector, that produce charge transport anomalies that have been previously misinterpreted as quantum efficiency variations. Performing simplistic flat-fielding therefore introduces systematic errors in the image processing pipeline. One measurement challenge we face is devising a combination of calibration methods and algorithms that can distinguish genuine quantum efficiency variations from charge transport effects. These device imperfections also confront spectroscopic applications, such as line centroid determination for precision radial velocity studies. Given the scientific benefits of improving both the precision and accuracy of astronomical measurements, we need to identify, characterize, and overcome these various detector artifacts. In retrospect, many of the detector features first identified in thick CCDs also afflict measurements made with more traditional CCD detectors, albeit often at a reduced level since the photocharge is subject to the perturbing influence of lateral electric fields for a shorter time interval. I provide a qualitative overview of the physical effects we think are responsible for the observed device properties, and provide some perspective for the work that lies ahead.

  4. Macromolecular diffractive imaging using imperfect crystals

    NASA Astrophysics Data System (ADS)

    Ayyer, Kartik; Yefanov, Oleksandr M.; Oberthür, Dominik; Roy-Chowdhury, Shatabdi; Galli, Lorenzo; Mariani, Valerio; Basu, Shibom; Coe, Jesse; Conrad, Chelsie E.; Fromme, Raimund; Schaffer, Alexander; Dörner, Katerina; James, Daniel; Kupitz, Christopher; Metz, Markus; Nelson, Garrett; Xavier, Paulraj Lourdu; Beyerlein, Kenneth R.; Schmidt, Marius; Sarrou, Iosifina; Spence, John C. H.; Weierstall, Uwe; White, Thomas A.; Yang, Jay-How; Zhao, Yun; Liang, Mengning; Aquila, Andrew; Hunter, Mark S.; Robinson, Joseph S.; Koglin, Jason E.; Boutet, Sébastien; Fromme, Petra; Barty, Anton; Chapman, Henry N.

    2016-02-01

    The three-dimensional structures of macromolecules and their complexes are mainly elucidated by X-ray protein crystallography. A major limitation of this method is access to high-quality crystals, which is necessary to ensure X-ray diffraction extends to sufficiently large scattering angles and hence yields information of sufficiently high resolution with which to solve the crystal structure. The observation that crystals with reduced unit-cell volumes and tighter macromolecular packing often produce higher-resolution Bragg peaks suggests that crystallographic resolution for some macromolecules may be limited not by their heterogeneity, but by a deviation of strict positional ordering of the crystalline lattice. Such displacements of molecules from the ideal lattice give rise to a continuous diffraction pattern that is equal to the incoherent sum of diffraction from rigid individual molecular complexes aligned along several discrete crystallographic orientations and that, consequently, contains more information than Bragg peaks alone. Although such continuous diffraction patterns have long been observed—and are of interest as a source of information about the dynamics of proteins—they have not been used for structure determination. Here we show for crystals of the integral membrane protein complex photosystem II that lattice disorder increases the information content and the resolution of the diffraction pattern well beyond the 4.5-ångström limit of measurable Bragg peaks, which allows us to phase the pattern directly. Using the molecular envelope conventionally determined at 4.5 ångströms as a constraint, we obtain a static image of the photosystem II dimer at a resolution of 3.5 ångströms. This result shows that continuous diffraction can be used to overcome what have long been supposed to be the resolution limits of macromolecular crystallography, using a method that exploits commonly encountered imperfect crystals and enables model-free phasing.

  5. Rule mining and classification in a situation assessment application: a belief-theoretic approach for handling data imperfections.

    PubMed

    Rohitha, K K; Hewawasam, G K; Premaratne, Kamal; Shyu, Mei-Ling

    2007-12-01

    Management of data imprecision and uncertainty has become increasingly important, especially in situation awareness and assessment applications where reliability of the decision-making process is critical (e.g., in military battlefields). These applications require the following: 1) an effective methodology for modeling data imperfections and 2) procedures for enabling knowledge discovery and quantifying and propagating partial or incomplete knowledge throughout the decision-making process. In this paper, using a Dempster-Shafer belief-theoretic relational database (DS-DB) that can conveniently represent a wider class of data imperfections, an association rule mining (ARM)-based classification algorithm possessing the desirable functionality is proposed. For this purpose, various ARM-related notions are revisited so that they could be applied in the presence of data imperfections. A data structure called belief itemset tree is used to efficiently extract frequent itemsets and generate association rules from the proposed DS-DB. This set of rules is used as the basis on which an unknown data record, whose attributes are represented via belief functions, is classified. These algorithms are validated on a simplified situation assessment scenario where sensor observations may have caused data imperfections in both attribute values and class labels. PMID:18179065

  6. Method and apparatus for evaluating multilayer objects for imperfections

    NASA Technical Reports Server (NTRS)

    Heyman, Joseph S. (Inventor); Abedin, Nurul (Inventor); Sun, Kuen J. (Inventor)

    1997-01-01

    A multilayer object having multiple layers arranged in a stacking direction is evaluated for imperfections such as voids, delaminations and microcracks. First, an acoustic wave is transmitted into the object in the stacking direction via an appropriate transducer/waveguide combination. The wave propagates through the multilayer object and is received by another transducer/waveguide combination preferably located on the same surface as the transmitting combination. The received acoustic wave is correlated with the presence or absence of imperfections by, e.g., generating pulse echo signals indicative of the received acoustic wave, wherein the successive signals form distinct groups over time. The respective peak amplitudes of each group are sampled and curve fit to an exponential curve, wherein a substantial fit of approximately 80-90% indicates an absence of imperfections and a significant deviation indicates the presence of imperfections. Alternatively, the time interval between distinct groups can be measured, wherein equal intervals indicate the absence of imperfections and unequal intervals indicate the presence of imperfections.

  7. Method and Apparatus for Evaluating Multilayer Objects for Imperfections

    NASA Technical Reports Server (NTRS)

    Heyman, Joseph S. (Inventor); Abedin, Nurul (Inventor); Sun, Kuen J. (Inventor)

    1999-01-01

    A multilayer object having multiple layers arranged in a stacking direction is evaluated for imperfections such as voids, delaminations and microcracks. First. an acoustic wave is transmitted into the object in the stacking direction via an appropriate transducer/waveguide combination. The wave propagates through the multilayer object and is received by another transducer/waveguide combination preferably located on the same surface as the transmitting combination. The received acoustic wave is correlated with the presence or absence of imperfections by, e.g., generating pulse echo signals indicative of the received acoustic wave. wherein the successive signals form distinct groups over time. The respective peak amplitudes of each group are sampled and curve fit to an exponential curve. wherein a substantial fit of approximately 80-90% indicates an absence of imperfections and a significant deviation indicates the presence of imperfections. Alternatively, the time interval between distinct groups can be measured. wherein equal intervals indicate the absence of imperfections and unequal intervals indicate the presence of imperfections.

  8. Dislocation stability in three-phase nanocomposites with imperfect interface

    NASA Astrophysics Data System (ADS)

    Zhao, Ying-Xin; Liu, You-Wen; Fang, Qi-Hong

    2014-10-01

    Interface imperfection can significantly affect the mechanical properties and failure mechanisms as well as the strength and toughness of nanocomposites. The elastic behavior of a screw dislocation in nanoscale coating with imperfect interface is studied in the three-phase composite cylinder model. The interface between inner nanoinhomogeneity and intermediate coating is assumed as perfectly bonded. The bonding between intermediate coating and outer matrix is considered to be imperfect with the assumption that interface imperfection is uniform, and a linear spring model is adopted to describe the weakness of imperfect interface. The explicit expression for image force acting on dislocation is obtained by means of a complex variable method. The analytic results indicate that inner interface effect and outer interface imperfection, simultaneously taken into account, would influence greatly image force, equilibrium position and stability of dislocation, and various critical parameters that would change dislocation stability. The weaker interface is a very strong trap for glide dislocation and, thus, a more effective barrier for slip transmission.

  9. Geoscience Data Puzzles: Developing Students' Ability to Make Meaning from Data

    NASA Astrophysics Data System (ADS)

    Kastens, K. A.; Turrin, M.

    2010-12-01

    One of the most fundamental aspects of geoscience expertise is the ability to extract insights from observational earth data. Where an expert might see trends, patterns, processes, and candidate causal relationships, a novice could look at the same data representation and see dots, wiggles and blotches of color. The problem is compounded when the student was not personally involved in collecting the data or samples and thus has no experiential knowledge of the Earth setting that the data represent. In other words, the problem is especially severe when students tap into the vast archives of professionally-collected data that the geoscience community has worked so hard to make available for instructional use over the internet. Moreover, most high school and middle school teachers did not themselves learn Earth Science through analyzing data, and they may lack skills and/or confidence needed to scaffold students through the process of learning to interpret realistically-complex data sets. We have developed “Geoscience Data Puzzles” with the paired goals of (a) helping students learn about the earth from data, and (b) helping teachers learn to teach with data. Geoscience Data Puzzles are data-using activities that purposefully present a low barrier-to-entry for teachers and a high ratio of insight-to-effort for students. Each Puzzle uses authentic geoscience data, but the data are carefully pre-selected in order to illuminate a fundamental Earth process within tractable snippets of data. Every Puzzle offers "Aha" moments, when the connection between data and process comes clear in a rewarding burst of insight. Every Puzzle is accompanied by a Pedagogical Content Knowledge (PCK) guide, which explicates the chain of reasoning by which the puzzle-solver can use the evidence provided by the data to construct scientific claims. Four types of reasoning are stressed: spatial reasoning, in which students make inferences from observations about location, orientation, shape

  10. Imperfect chemical female mimicry in males of the ant Cardiocondyla obscurior

    NASA Astrophysics Data System (ADS)

    Cremer, Sylvia; D'Ettorre, Patrizia; Drijfhout, Falko P.; Sledge, Matthew F.; Turillazzi, Stefano; Heinze, Jürgen

    2008-11-01

    Winged and wingless males coexist in the ant Cardiocondyla obscurior. Wingless (“ergatoid”) males never leave their maternal colony and fight remorselessly among each other for the access to emerging females. The peaceful winged males disperse after about 10 days, but beforehand also mate in the nest. In the first 5 days of their life, winged males perform a chemical female mimicry that protects them against attack and even makes them sexually attractive to ergatoid males. When older, the chemical profile of winged males no longer matches that of virgin females; nevertheless, they are still tolerated, which so far has been puzzling. Contrasting this general pattern, we have identified a single aberrant colony in which all winged males were attacked and killed by the ergatoid males. A comparative analysis of the morphology and chemical profile of these untypical attacked winged males and the tolerated males from several normal colonies revealed that normal old males are still performing some chemical mimicry to the virgin queens, though less perfect than in their young ages. The anomalous attacked winged males, on the other hand, had a very different odour to the females. Our study thus exemplifies that the analysis of rare malfunctioning can add valuable insight on functioning under normal conditions and allows the conclusion that older winged males from normal colonies of the ant C. obscurior are guarded through an imperfect chemical female mimicry, still close enough to protect against attacks by the wingless fighters yet dissimilar enough not to elicit their sexual interest.

  11. Early puzzle play: a predictor of preschoolers' spatial transformation skill.

    PubMed

    Levine, Susan C; Ratliff, Kristin R; Huttenlocher, Janellen; Cannon, Joanna

    2012-03-01

    Individual differences in spatial skill emerge prior to kindergarten entry. However, little is known about the early experiences that may contribute to these differences. The current study examined the relation between children's early puzzle play and their spatial skill. Children and parents (n = 53) were observed at home for 90 min every 4 months (6 times) between 2 and 4 years of age (26 to 46 months). When children were 4 years 6 months old, they completed a spatial task involving mental transformations of 2-dimensional shapes. Children who were observed playing with puzzles performed better on this task than those who did not, controlling for parent education, income, and overall parent word types. Moreover, among those children who played with puzzles, frequency of puzzle play predicted performance on the spatial transformation task. Although the frequency of puzzle play did not differ for boys and girls, the quality of puzzle play (a composite of puzzle difficulty, parent engagement, and parent spatial language) was higher for boys than for girls. In addition, variation in puzzle play quality predicted performance on the spatial transformation task for girls but not for boys. Implications of these findings as well as future directions for research on the role of puzzle play in the development of spatial skill are discussed. PMID:22040312

  12. Early Puzzle Play: A predictor of preschoolers’ spatial transformation skill

    PubMed Central

    Levine, S.C.; Ratliff, K.R.; Huttenlocher, J.; Cannon, J.

    2011-01-01

    Individual differences in spatial skill emerge prior to kindergarten entry. However, little is known about the early experiences that may contribute to these differences. The current study examines the relation between children’s early puzzle play and their spatial skill. Children and parents (n = 53) were observed at home for 90 minutes every four months (six times) between 2 and 4 years of age (26 to 46 months). When children were 4 years 6 months old, they completed a spatial task involving mental transformations of 2D shapes. Children who were observed playing with puzzles performed better on this task than those who did not, controlling for parent education, income, and overall parent word types. Moreover, among those children who played with puzzles, frequency of puzzle play predicted performance on the spatial transformation task. Although the frequency of puzzle play did not differ for boys and girls, the quality of puzzle play (a composite of puzzle difficulty, parent engagement, and parent spatial language) was higher for boys than girls. In addition, variation in puzzle play quality predicted performance on the spatial transformation task for girls but not boys. Implications of these findings as well as future directions for research on the role of the role of puzzle play in the development of spatial skill are discussed. PMID:22040312

  13. Modified Sigmund sputtering theory: isotopic puzzle

    NASA Astrophysics Data System (ADS)

    Zhang, Z. L.; Zhang, L.

    2005-05-01

    The theory of anisotropic sputtering proposed by Zhang [Z.L. Zhang, Phys. Rev. B 71 026101 (2005).] and [Z.L. Zhang and L. Zhang, Radiat. Eff. Defects Solids 159(5) 301 (2004).] has been generalized to sputtering of isotopic mixtures. The present theory (modified Sigmund theory) has been shown to fit numerous simulations and experimental measurements, including energy and angular distribution of sputtered atoms. In particular, the theory has successfully solved the isotope puzzle of sputtering induced by low energy and heavy ion bombardment.

  14. TOPICAL REVIEW The cosmological constant puzzle

    NASA Astrophysics Data System (ADS)

    Bass, Steven D.

    2011-04-01

    The accelerating expansion of the Universe points to a small positive vacuum energy density and negative vacuum pressure. A strong candidate is the cosmological constant in Einstein's equations of general relativity. Possible contributions are zero-point energies and the condensates associated with spontaneous symmetry breaking. The vacuum energy density extracted from astrophysics is 1056 times smaller than the value expected from quantum fields and standard model particle physics. Is the vacuum energy density time dependent? We give an introduction to the cosmological constant puzzle and ideas how to solve it.

  15. Decision support in an imperfect world

    SciTech Connect

    Chang, C.L.

    1983-01-01

    By a decision support system it is meant an expert system that the user can use to inquire about information to make his decision. Such a system will be based on an expert knowledge base. It is believed that the knowledge base is more than facts and rules. It may include less tangible and less codifiable factors like opinions, judgments, educated guesses, as well as factual information and logic rules for reasoning. That is, the knowledge may be explicit, logical, heuristic, or fuzzy. This paper presents some methods to add fuzzy information into a relational data base. Specifically it considers the treatments of fuzzy queries. An answer to a fuzzy query will be a fuzzy set from which a further detailed study can be made. 13 references.

  16. 3D puzzle reconstruction for archeological fragments

    NASA Astrophysics Data System (ADS)

    Jampy, F.; Hostein, A.; Fauvet, E.; Laligant, O.; Truchetet, F.

    2015-03-01

    The reconstruction of broken artifacts is a common task in archeology domain; it can be supported now by 3D data acquisition device and computer processing. Many works have been dedicated in the past to reconstructing 2D puzzles but very few propose a true 3D approach. We present here a complete solution including a dedicated transportable 3D acquisition set-up and a virtual tool with a graphic interface allowing the archeologists to manipulate the fragments and to, interactively, reconstruct the puzzle. The whole lateral part is acquired by rotating the fragment around an axis chosen within a light sheet thanks to a step-motor synchronized with the camera frame clock. Another camera provides a top view of the fragment under scanning. A scanning accuracy of 100μm is attained. The iterative automatic processing algorithm is based on segmentation into facets of the lateral part of the fragments followed by a 3D matching providing the user with a ranked short list of possible assemblies. The device has been applied to the reconstruction of a set of 1200 fragments from broken tablets supporting a Latin inscription dating from the first century AD.

  17. Magic star puzzle for educational mathematics

    NASA Astrophysics Data System (ADS)

    Gan, Yee Siang; Fong, Wan Heng; Sarmin, Nor Haniza

    2013-04-01

    One of the interesting fields in recreational mathematics is the magic number arrangement. There are different kinds of arrays in the arrangement for a group of numbers. In particular, one of the arrays in magic number arrangement is called magic star. In fact, magic star involves combinatorics that contributes to geometrical analysis and number theory. Hence, magic star is suitable to be introduced as educational mathematics to cultivate interest in different area of mathematics. To obtain the solutions of normal magic stars of order six, the possible sets of numbers for every line in a magic star have been considered. Previously, the calculation for obtaining the solutions has been done manually which is time-consuming. Therefore, a programming code to generate all the fundamental solutions for normal magic star of order six without including the properties of rotation and reflection has been done. In this puzzle, a magic star puzzle is created by using Matlab software, which enables a user to verify the entries for the cells of magic star of order six. Moreover, it is also user-friendly as it provides interactive commands on the inputs given by the user, which enables the user to detect the incorrect inputs. In addition, user can also choose to view all the fundamental solutions as generated by the programming code.

  18. Sudoku Puzzles for First-Year Organic Chemistry Students

    ERIC Educational Resources Information Center

    Perez, Alice L.; Lamoureux, G.

    2007-01-01

    Sudoku puzzle was designed to teach about amino acids and functional groups to the students of undergraduate organic chemistry students. The puzzles focus on helping the student learn the name, 3-letter code and 1-letter code of common amino acids and functional groups.

  19. Crossword Puzzles as Learning Tools in Introductory Soil Science

    ERIC Educational Resources Information Center

    Barbarick, K. A.

    2010-01-01

    Students in introductory courses generally respond favorably to novel approaches to learning. To this end, I developed and used three crossword puzzles in spring and fall 2009 semesters in Introductory Soil Science Laboratory at Colorado State University. The first hypothesis was that crossword puzzles would improve introductory soil science…

  20. Decoding Codewords: Statistical Analysis of a Newspaper Puzzle

    ERIC Educational Resources Information Center

    Meacock, Susan; Meacock, Geoff

    2012-01-01

    In recent years English newspapers have started featuring a number of puzzles other than the ubiquitous crossword. Many of the puzzles are of Japanese origin such as Sudoku, Kakuro or Hidato. However, one recent one is very English and is called variously Cross-code, Alphapuzzle or some other name. In this article, it will be known as Codeword.…

  1. Enumerating Small Sudoku Puzzles in a First Abstract Algebra Course

    ERIC Educational Resources Information Center

    Lorch, Crystal; Lorch, John

    2008-01-01

    Two methods are presented for counting small "essentially different" sudoku puzzles using elementary group theory: one method (due to Jarvis and Russell) uses Burnside's counting formula, while the other employs an invariant property of sudoku puzzles. Ideas are included for incorporating this material into an introductory abstract algebra course.…

  2. Sharing Skills: Reach for a Book; Book Week Puzzle Packet.

    ERIC Educational Resources Information Center

    Bauer, Caroline Feller

    1986-01-01

    Reach for a Book is the theme for Children's Book Week 1986, and book presentations, activities, and exhibits to emphasize the joy of reading are listed. A Book Week Puzzle Packet provides two puzzles designed to reinforce the idea of using the card catalog to find materials on specific subjects. (EM)

  3. A Puzzle Used to Teach the Cardiac Cycle

    ERIC Educational Resources Information Center

    Marcondes, Fernanda K.; Moura, Maria J. C. S.; Sanches, Andrea; Costa, Rafaela; Oliveira de Lima, Patricia; Groppo, Francisco Carlos; Amaral, Maria E. C.; Zeni, Paula; Gaviao, Kelly Cristina; Montrezor, Luís H.

    2015-01-01

    The aim of the present article is to describe a puzzle developed for use in teaching cardiac physiology classes. The puzzle presents figures of phases of the cardiac cycle and a table with five columns: phases of cardiac cycle, atrial state, ventricular state, state of atrioventricular valves, and pulmonary and aortic valves. Chips are provided…

  4. Jigsaw Puzzles. Australian Early Childhood Resource Booklets, No. 3.

    ERIC Educational Resources Information Center

    Fleer, Marilyn

    This booklet examines the educational value of jigsaw puzzles and gives practical suggestions on how to select and make them for use by children ages 1 through 8. It asserts that jigsaw puzzles provide children with the opportunity to develop problem-solving strategies, and discusses a theory of adult-child interaction that encourages the…

  5. Categorization Competence by Youth in Non-School Material (Puzzles)

    ERIC Educational Resources Information Center

    Buell, Robert R.; And Others

    1970-01-01

    Presents the procedures, results, and conclusions of a study to investigate the effects of (1) sex, (2) intelligence, and (3) prior experience in puzzle solving on the categorization skills of youth. A two-dimensional type puzzle involving 4 sorting variables was given to 110 ninth graders. 22 subjects, age from 7 to 18 were given a 3-dimensional…

  6. Imperfection Insensitivity Analyses of Advanced Composite Tow-Steered Shells

    NASA Technical Reports Server (NTRS)

    Wu, K. Chauncey; Farrokh, Babak; Stanford, Bret K.; Weaver, Paul M.

    2016-01-01

    Two advanced composite tow-steered shells, one with tow overlaps and another without overlaps, were previously designed, fabricated and tested in end compression, both without cutouts, and with small and large cutouts. In each case, good agreement was observed between experimental buckling loads and supporting linear bifurcation buckling analyses. However, previous buckling tests and analyses have shown historically poor correlation, perhaps due to the presence of geometric imperfections that serve as failure initiators. For the tow-steered shells, their circumferential variation in axial stiffness may have suppressed this sensitivity to imperfections, leading to the agreement noted between tests and analyses. To investigate this further, a numerical investigation was performed in this study using geometric imperfections measured from both shells. Finite element models of both shells were analyzed first without, and then, with measured imperfections that were then, superposed in different orientations around the shell longitudinal axis. Small variations in both the axial prebuckling stiffness and global buckling load were observed for the range of imperfections studied here, which suggests that the tow steering, and resulting circumferentially varying axial stiffness, may result in the test-analysis correlation observed for these shells.

  7. Bio-chemical sensor based on imperfected plastic optical fiber

    NASA Astrophysics Data System (ADS)

    Babchenko, Anatoly; Chernyak, Valeri; Maryles, Jonathan

    2007-05-01

    In this paper we report results for an intrinsic evanescent field sensor based on not-regular plastic optical fiber with polymer film containing Malachite Green MG +([PhC(C 6H 4NMe II) 3] +) as an absorption reagent, which coats the fiber's imperfected area. A theoretical model was developed which shows that changes of light in such structure result from the attenuation of light in the strait and bent imperfected fiber. In this model, the imperfected area with malachite green polymer film is replaced by a uniform layer with a complex refractive index. The changes in color and absorption characteristics of the polymer film depend on the acidic and basic environmental properties in the sensing area. Additional increase of the evanescent field interaction can be achieved by decrease the bending radius of the fiber with the coated imperfection area at the middle of the bent fiber. An imperfected plastic optical fiber with Malachite Green coating has been presented for the detection of ammonia vapor. The initial results show that depending on the sensing application demands, it is possible to design a high sensitive sensor with a relatively long response time, while when the demands require fast response times the sensor with less sensitivity can be used. In addition, the sensors' sensitivity can be calibrated in real-time by changing the bending radius.

  8. Marginalized Particle Filter for Blind Signal Detection with Analog Imperfections

    NASA Astrophysics Data System (ADS)

    Yoshida, Yuki; Hayashi, Kazunori; Sakai, Hideaki; Bocquet, Wladimir

    Recently, the marginalized particle filter (MPF) has been applied to blind symbol detection problems over selective fading channels. The MPF can ease the computational burden of the standard particle filter (PF) while offering better estimates compared with the standard PF. In this paper, we investigate the application of the blind MPF detector to more realistic situations where the systems suffer from analog imperfections which are non-linear signal distortion due to the inaccurate analog circuits in wireless devices. By reformulating the system model using the widely linear representation and employing the auxiliary variable resampling (AVR) technique for estimation of the imperfections, the blind MPF detector is successfully modified to cope with the analog imperfections. The effectiveness of the proposed MPF detector is demonstrated via computer simulations.

  9. Multiwave diffraction, phase problem, and extinction in imperfect crystals

    SciTech Connect

    Dmitrienko, V. E.

    2009-11-15

    The extinction effects of multiwave diffraction in imperfect crystals have been investigated. It is shown that the presence of extinction in the direct diffraction channel may lead to errors in determining the relative phases of structural amplitudes by the multiwave diffraction method (i.e., by interference with indirect excitation). The reason is that the dependence of the reflection intensity on the structural amplitude in imperfect crystals is generally nonquadratic (as in the kinematic theory), nonlinear (as in the dynamic theory), and is not even somewhat intermediate. These effects open up new possibilities for using multiwave diffraction for the direct study of the extinction and, therefore, quantitatively characterize the imperfection of crystal structures with known values and phases of structural amplitudes.

  10. Static Isotropic Space-Times with Radially Imperfect Fluids

    NASA Astrophysics Data System (ADS)

    Konopka, Tomasz

    When one is solving the equations of general relativity in a symmetric sector, it is natural to consider the same symmetry for the geometry and stress-energy. This implies that for static and isotropic space-times, the most general natural stress-energy tensor is a sum of a perfect fluid and a radially imperfect fluid component. In the special situations where the perfect fluid component vanishes or is a space-time constant, the solutions to Einstein's equations can be thought of as modified Schwarzschild and Schwarzschild-de Sitter spaces. Exact solutions of this type are derived and it is shown that whereas deviations from the unmodified solutions can be made small, among the manifestations of the imperfect fluid component is a shift in angular momentum scaling for orbiting test bodies at large radius. Based on this effect, the question of whether the imperfect fluid component can feasibly describe dark matter phenomenology is addressed.

  11. Remote preparation of W states from imperfect bipartite sources

    NASA Astrophysics Data System (ADS)

    Moreno, M. G. M.; Cunha, Márcio M.; Parisio, Fernando

    2016-06-01

    Several proposals to produce tripartite W-type entanglement are probabilistic even if no imperfections are considered in the processes. We provide a deterministic way to remotely create W states out of an EPR source. The proposal is made viable through measurements (which can be demolitive) in an appropriate three-qubit basis. The protocol becomes probabilistic only when source flaws are considered. It turns out that, even in this situation, it is robust against imperfections in two senses: (i) It is possible, after postselection, to create a pure ensemble of W states out of an EPR source containing a systematic error; (ii) If no postselection is done, the resulting mixed state has a fidelity, with respect to a pure |Wrangle , which is higher than that of the imperfect source in comparison with an ideal EPR source. This simultaneously amounts to entanglement concentration and lifting.

  12. The Puzzle of HD 104994 (WR 46)

    NASA Astrophysics Data System (ADS)

    Marchenko, Sergey V.; Arias, Julia; Barbá, Rodolfo; Balona, Luis; Moffat, Anthony F. J.; Niemela, Virpi S.; Shara, Michael M.; Sterken, Christiaan

    2000-10-01

    Intense coordinated spectroscopic and photometric monitoring of the suspected Wolf-Rayet binary WR 46 in 1999 reveals clear periodic variations, P=0.329+/-0.013 days, in the radial velocities of the emission lines of highest ionization potential, O VI and N V, found deepest in the Wolf-Rayet wind and thus least likely to be perturbed by a companion. These are accompanied by coherent variability in the profiles of lines with lower ionization/excitation potential and in the continuum flux. Most probably originating from orbital motion of the Wolf-Rayet component of the binary, this periodic radial velocity signal disappears from time to time, thus creating a puzzle yet to be solved. We show that the entangled patterns of the line profile variability are mainly governed by transitions between high and low states of the system's continuum flux. Based in part on observations obtained at the European Southern Observatory, La Silla, Chile (ESO program 62.H-0110).

  13. The electron screening puzzle and nuclear clustering

    DOE PAGESBeta

    Spitaleri, C.; Bertulani, C. A.; Fortunato, L.; Vitturi, A.

    2016-02-12

    Accurate measurements of nuclear reactions of astrophysical interest within, or close to, the Gamow peak show evidence of an unexpected effect attributed to the presence of atomic electrons in the target. The experiments need to include an effective "screening" potential to explain the enhancement of the cross sections at the lowest measurable energies. Despite various theoretical studies conducted over the past 20 years and numerous experimental measurements, a theory has not yet been found that can explain the cause of the exceedingly high values of the screening potential needed to explain the data. Furthermore, in this letter we show thatmore » instead of an atomic physics solution of the "electron screening puzzle", the reason for the large screening potential values is in fact due to clusterization effects in nuclear reactions, in particular for reaction involving light nuclei.« less

  14. The puzzle of TRPV4 channelopathies

    PubMed Central

    Nilius, Bernd; Voets, Thomas

    2013-01-01

    Hereditary channelopathies, that is, mutations in channel genes that alter channel function and are causal for the pathogenesis of the disease, have been described for several members of the transient receptor potential channel family. Mutations in the TRPV4 gene, encoding a polymodal Ca2+ permeable channel, are causative for several human diseases, which affect the skeletal system and the peripheral nervous system, with highly variable phenotypes. In this review, we describe the phenotypes of TRPV4 channelopathies and overlapping symptoms. Putative mechanisms to explain the puzzle, and how mutations in the same region of the channel cause different diseases, are discussed and experimental approaches to tackle this surprising problem are suggested. PMID:23306656

  15. A PUZZLE INVOLVING GALACTIC BULGE MICROLENSING EVENTS

    SciTech Connect

    Cohen, Judith G.; Gould, Andrew; Johnson, Jennifer A.; Thompson, Ian B.; Feltzing, Sofia; Bensby, Thomas; Huang Wenjin; Melendez, Jorge; Lucatello, Sara; Asplund, Martin E-mail: gould@astronomy.ohio-state.edu E-mail: ian@obs.carnegiescience.edu E-mail: tbensby@eso.org E-mail: jorge@astro.up.pt E-mail: asplund@MPA-Garching.MPG.DE

    2010-03-01

    We study a sample of 16 microlensed Galactic bulge main-sequence turnoff region stars for which high-dispersion spectra have been obtained with detailed abundance analyses. We demonstrate that there is a very strong and highly statistically significant correlation between the maximum magnification of the microlensed bulge star and the value of the [Fe/H] deduced from the high resolution spectrum of each object. Physics demands that this correlation, assuming it to be real, be the result of some sample bias. We suggest several possible explanations, but are forced to reject them all, and are left puzzled. To obtain a reliable metallicity distribution in the Galactic bulge based on microlensed dwarf stars, it will be necessary to resolve this issue through the course of additional observations.

  16. Solving the Puzzle of Subhalo Spins

    NASA Astrophysics Data System (ADS)

    Wang, Yang; Lin, Weipeng; Pearce, Frazer R.; Lux, Hanni; Muldrew, Stuart I.; Onions, Julian

    2015-03-01

    Investigating the spin parameter distribution of subhalos in two high-resolution isolated halo simulations, recent work by Onions et al. suggested that typical subhalo spins are consistently lower than the spin distribution found for field halos. To further examine this puzzle, we have analyzed simulations of a cosmological volume with sufficient resolution to resolve a significant subhalo population. We confirm the result of Onions et al. and show that the typical spin of a subhalo decreases with decreasing mass and increasing proximity to the host halo center. We interpret this as the growing influence of tidal stripping in removing the outer layers, and hence the higher angular momentum particles, of the subhalos as they move within the host potential. Investigating the redshift dependence of this effect, we find that the typical subhalo spin is smaller with decreasing redshift. This indicates a temporal evolution, as expected in the tidal stripping scenario.

  17. Bullet-Block Science Video Puzzle

    NASA Astrophysics Data System (ADS)

    Shakur, Asif

    2015-01-01

    A science video blog,1 which has gone viral, shows a wooden block shot by a vertically aimed rifle. The video2 shows that the block hit dead center goes exactly as high as the one shot off-center. (Fig. 1). The puzzle is that the block shot off-center carries rotational kinetic energy in addition to the gravitational potential energy. This leads a majority of the bloggers to claim that the block shot off-center should not go as high as the one shot dead center. Others have claimed that the energy tied up as rotational energy is insignificant and the two blocks should rise to the same height within experimental error.

  18. The electron screening puzzle and nuclear clustering

    NASA Astrophysics Data System (ADS)

    Spitaleri, C.; Bertulani, C. A.; Fortunato, L.; Vitturi, A.

    2016-04-01

    Accurate measurements of nuclear reactions of astrophysical interest within, or close to, the Gamow peak show evidence of an unexpected effect attributed to the presence of atomic electrons in the target. The experiments need to include an effective "screening" potential to explain the enhancement of the cross sections at the lowest measurable energies. Despite various theoretical studies conducted over the past 20 years and numerous experimental measurements, a theory has not yet been found that can explain the cause of the exceedingly high values of the screening potential needed to explain the data. In this letter we show that instead of an atomic physics solution of the "electron screening puzzle", the reason for the large screening potential values is in fact due to clusterization effects in nuclear reactions, in particular for reaction involving light nuclei.

  19. A puzzle used to teach the cardiac cycle.

    PubMed

    Marcondes, Fernanda K; Moura, Maria J C S; Sanches, Andrea; Costa, Rafaela; de Lima, Patricia Oliveira; Groppo, Francisco Carlos; Amaral, Maria E C; Zeni, Paula; Gaviao, Kelly Cristina; Montrezor, Luís H

    2015-03-01

    The aim of the present article is to describe a puzzle developed for use in teaching cardiac physiology classes. The puzzle presents figures of phases of the cardiac cycle and a table with five columns: phases of cardiac cycle, atrial state, ventricular state, state of atrioventricular valves, and pulmonary and aortic valves. Chips are provided for use to complete the table. Students are requested to discuss which is the correct sequence of figures indicating the phases of cardiac cycle. Afterward, they should complete the table with the chips. Students of biology, dentistry, medicine, pharmacy, and nursing graduation courses from seven institutions performed the puzzle evaluation. They were invited to indicate whether the puzzle had been useful for learning about the subject by filling one of four alternatives. Of the students, 4.6% answered that it was not necessary but helped them to confirm what they had learned, 64.5% reported that although they had previously understood the cardiac cycle, the puzzle helped them to solve doubts and promoted a better understanding of it, and 30.9% said that they needed the puzzle to understand the cardiac cycle, without differences among courses, institutions, and course semesters. The results of the present study suggest that a simple and inexpensive puzzle may be useful as an active learning methodology applied after the theoretical lecture, as a complementary tool for studying cardiac cycle physiology. PMID:25727466

  20. Information Imperfections: The Achilles' Heel of Entitlement Plans

    ERIC Educational Resources Information Center

    Bridge, Gary

    1978-01-01

    Discusses some crucial questions about voucher systems in education and examines the major weakness of the voucher and entitlement proposals, i.e., information imperfections that limit the ability of individuals, especially low-income and less educated people, to choose intelligently among competing alternatives. (BR)

  1. Modelling occurrence and abundance of species when detection is imperfect

    USGS Publications Warehouse

    Royle, J. Andrew; Nichols, J.D.; Kery, M.

    2005-01-01

    Relationships between species abundance and occupancy are of considerable interest in metapopulation biology and in macroecology. Such relationships may be described concisely using probability models that characterize variation in abundance of a species. However, estimation of the parameters of these models in most ecological problems is impaired by imperfect detection. When organisms are detected imperfectly, observed counts are biased estimates of true abundance, and this induces bias in stated occupancy or occurrence probability. In this paper we consider a class of models that enable estimation of abundance/occupancy relationships from counts of organisms that result from surveys in which detection is imperfect. Under such models, parameter estimation and inference are based on conventional likelihood methods. We provide an application of these models to geographically extensive breeding bird survey data in which alternative models of abundance are considered that include factors that influence variation in abundance and detectability. Using these models, we produce estimates of abundance and occupancy maps that honor important sources of spatial variation in avian abundance and provide clearly interpretable characterizations of abundance and occupancy adjusted for imperfect detection.

  2. Vibration and guiding of moving media with edge weave imperfections

    NASA Astrophysics Data System (ADS)

    Kartik, V.; Wickert, J. A.

    2006-03-01

    This paper examines the steady-state-forced vibration of a moving medium that is guided by a partial elastic foundation, and where geometric imperfections on the medium's edge act as an excitation source. Such a system is of technical interest in the areas of web handling and magnetic tape transport where externally pressurized air bearing guides are sometimes used to control lateral position. The axially moving strip is modeled here as a string that is guided by elastic foundation segments, and that is subjected to traveling wave excitation as the edge's imperfection interacts with the foundation. The equation of motion for this "moving medium and moving load" system incorporates a skew-symmetric Coriolis acceleration component that arises from convection. The governing equation is cast in state-space form, with one symmetric and one skew-symmetric operator, as is characteristic of gyroscopic systems. Through modal analysis, the forced response of the system is obtained to the complex harmonic excitation associated with the interaction between the edge's weave pattern and the guides. Parameter studies are presented in the transport speed, foundation stiffness, guide placement, guide width, and imperfection wavelength. Of potential technological application, for a given wavelength of the edge's imperfection, it is possible to reduce the medium's vibration at a certain location by judiciously selecting the locations and spans of the foundation segments.

  3. Solar System Puzzle Kit: An Activity for Earth and Space Science.

    ERIC Educational Resources Information Center

    Vogt, Gregory L.; Rosenberg, Carla B.

    This Solar System Puzzle Kit for grades 5-8, allows students to create an eight-cube paper puzzle of the solar system and may be duplicated for classroom use or used as a take home activity for children and parents. By assembling the puzzle, hand-coloring the bodies of the solar system, and viewing the puzzle's 12 sides, students can reinforce…

  4. Puzzling through General Chemistry: A Light-Hearted Approach to Engaging Students with Chemistry Content

    ERIC Educational Resources Information Center

    Boyd, Susan L.

    2007-01-01

    Several puzzles are designed to be used by chemistry students as learning tools and teach them basic chemical concepts. The topics of the puzzles are based on the chapters from Chemistry, The Central Science used in general chemistry course and the puzzles are in various forms like crosswords, word searches, number searches, puzzles based on…

  5. Teaching the Blue-Eyed Islanders Puzzle in a Liberal Arts Mathematics Course

    ERIC Educational Resources Information Center

    Shea, Stephen

    2012-01-01

    The blue-eyed islanders puzzle is an old and challenging logic puzzle. This is a narrative of an experience introducing a variation of this puzzle on the first day of classes in a liberal arts mathematics course for non-majors. I describe an exercise that was used to facilitate the class's understanding of the puzzle.

  6. Quantum key distribution: vulnerable if imperfectly implemented

    NASA Astrophysics Data System (ADS)

    Leuchs, G.

    2013-10-01

    We report several vulnerabilities found in Clavis2, the flagship quantum key distribution (QKD) system from ID Quantique. We show the hacking of a calibration sequence run by Clavis2 to synchronize the Alice and Bob devices before performing the secret key exchange. This hack induces a temporal detection efficiency mismatch in Bob that can allow Eve to break the security of the cryptosystem using faked states. We also experimentally investigate the superlinear behaviour in the single-photon detectors (SPDs) used by Bob. Due to this superlinearity, the SPDs feature an actual multi-photon detection probability which is generally higher than the theoretically-modelled value. We show how this increases the risk of detector control attacks on QKD systems (including Clavis2) employing such SPDs. Finally, we review the experimental feasibility of Trojan-horse attacks. In the case of Clavis2, the objective is to read Bob's phase modulator to acquire knowledge of his basis choice as this information suffices for constructing the raw key in the Scarani-Acin-Ribordy-Gisin 2004 (SARG04) protocol. We work in close collaboration with ID Quantique and for all these loopholes, we notified them in advance. Wherever possible, we or ID Quantique proposed countermeasures and they implemented suitable patches and upgrade their systems.

  7. Latest Zika Puzzle: How U.S. Patient Infected Caregiver

    MedlinePlus

    ... https://medlineplus.gov/news/fullstory_159925.html Latest Zika Puzzle: How U.S. Patient Infected Caregiver Officials say ... MONDAY, July 18, 2016 (HealthDay News) -- The mysterious Zika virus continues to surprise health scientists. On Monday, ...

  8. Error-Driven Knowledge Restructuring in Categorization

    ERIC Educational Resources Information Center

    Kalish, Michael L.; Lewandowsky, Stephan; Davies, Melissa

    2005-01-01

    Knowledge restructuring occurs when people shift to a new strategy or representation during learning. Although knowledge restructuring can frequently be experimentally encouraged, there are instances in which people resist restructuring and continue to use an expedient but imperfect initial strategy. The authors report 3 category learning…

  9. Peripartum cardiomyopathy: A puzzle closer to solution

    PubMed Central

    Fett, James D

    2014-01-01

    Peripartum cardiomyopathy (PPCM) represents new heart failure in a previously heart-healthy peripartum patient. It is necessary to rule out all other known causes of heart failure before accepting a diagnosis of PPCM. The modern era for PPCM in the United States and beyond began with the report of the National Institutes of Health PPCM Workshop in 2000, clarifying all then-currently known aspects of the disease. Since then, hundreds of publications have appeared, an indication of how devastating this disease can be to young mothers and their families and the urgent desire to find solutions for its cause and better treatment. The purpose of this review is to highlight the important advances that have brought us nearer to the solution of this puzzle, focusing on what we have learned about PPCM since 2000; and what still remains unanswered. Despite many improvements in outcome, we still do not know the actual triggers that initiate the pathological process; but realize that cardiac angiogenic imbalances resulting from complex pregnancy-related immune system and hormonal changes play a key role. PMID:24669290

  10. Solving the puzzle of autoimmunity: critical questions

    PubMed Central

    Smilek, Dawn E.

    2015-01-01

    Despite recent advances in delineating the pathogenic mechanisms of autoimmune disease, the puzzle that reveals the true picture of these diverse immunological disorders is yet to be solved. We know that the human leukocyte antigen (HLA) loci as well as many different genetic susceptibility loci with relatively small effect sizes predispose to various autoimmune diseases and that environmental factors are involved in triggering disease. Models for mechanisms of disease become increasingly complex as relationships between components of both the adaptive and innate immune systems are untangled at the molecular level. In this article, we pose some of the important questions about autoimmunity where the answers will advance our understanding of disease pathogenesis and improve the rational design of novel therapies. How is autoimmunity triggered, and what components of the immune response drive the clinical manifestations of disease? What determines whether a genetically predisposed individual will develop an autoimmune disease? Is restoring immune tolerance the secret to finding cures for autoimmune disease? Current research efforts seek answers to these big questions. PMID:25750735

  11. Hepatitis B virus: the genotype E puzzle.

    PubMed

    Andernach, Iris E; Hübschen, Judith M; Muller, Claude P

    2009-07-01

    Hepatitis B virus (HBV) is highly endemic throughout sub-Saharan Africa. One of the two genotypes A and E dominates in most countries. With several subgenotypes and variants, genotype A is more diverse in Africa (4.00%) than in the rest of the world (2.96%), suggesting an African origin and a long history on the continent. Despite the African slave trade, genotype E has only sporadically been found within the Americas, indicating that this genotype was introduced only during the past 200 years into the general African population. A short history for this genotype in Africa is also supported by its conspicuously low genetic diversity (1.75%), which contrasts, however, with its excessively high HBsAg prevalence and its extensive spread throughout the vast West-African genotype E crescent. We discuss the spread and routes of transmission of genotype E and suggest that the distribution and current high prevalence levels of HBV (genotype E) in Africa are the result of the extensive use of unsafe needles, potentially solving the current African genotype E puzzle and shedding new light on the high HBV prevalence in Africa. PMID:19475565

  12. Climate Change: Geophysical Puzzles and Some Answers

    NASA Astrophysics Data System (ADS)

    Singer, S. F.

    2009-04-01

    Climate change is a complex subject, involving many disciplines of geophysics - from geodynamics and meteorology to solar-terrestrial relationships and solar-planetary dynamics. We will discuss a number of scientific puzzles, many still unanswered: · How much of climate change of the past century is anthropogenic and how much is caused by Nature? · How reliable are temperature data of the atmosphere and of the surface, including sea surface? · How reliable are climate models used to calculate future temperatures? · How good is the evidence for solar forcing of climate? · On a decadal time scale, is natural forcing mainly solar or due to internal oscillations? · Can the 1500-year cycle discovered in ice cores explain the Medieval Warming and Little Ice Age? · Why does sea level rise show no acceleration - and how to account for its observed magnitude? -------------------------------------------------------------------- Much of the presentation is based on the NIPCC report "Nature - Not Human Activity - Rules the Climate" http://www.sepp.org/publications/NIPCC_final.pdf

  13. A Discourse Analysis of the Periphrastic Imperfect in the Greek New Testament Writings of Luke

    ERIC Educational Resources Information Center

    Johnson, Carl E.

    2010-01-01

    Motivated by Bloomfield's belief that linguistic variation is not without motivation, this paper seeks to determine the distinction between the morphological imperfect and periphrastic imperfect of Koine Greek within the New Testament writings of Luke. This study suggests that: (1) The periphrastic imperfect occurs only within narrative…

  14. Noncontacting thermoelectric detection of material imperfections in metals

    SciTech Connect

    Peter B. Nagy; Adnan H. Nayfeh; Waseem I. Faidi; Hector Carreon; Balachander Lakshminaraya; Feng Yu; Bassam Abu-Nabah

    2005-06-17

    This project was aimed at developing a new noncontacting thermoelectric method for nondestructive detection of material imperfections in metals. The method is based on magnetic sensing of local thermoelectric currents around imperfections when a temperature gradient is established throughout a conducting specimen by external heating and cooling. The surrounding intact material serves as the reference electrode therefore the detection sensitivity could be very high if a sufficiently sensitive magnetometer is used in the measurements. This self-referencing, noncontacting, nondestructive inspection technique offers the following distinct advantages over conventional methods: high sensitivity to subtle variations in material properties, unique insensitivity to the size, shape, and other geometrical features of the specimen, noncontacting nature with a substantial stand-off distance, and the ability to probe relatively deep into the material. The potential applications of this method cover a very wide range from detection metallic inclusions and segregations, inhomogeneities, and tight cracks to characterization of hardening, embrittlement, fatigue, texture, and residual stresses.

  15. Distribution of radiative crystal imperfections through a silicon ingot

    SciTech Connect

    Flø, A. Burud, I.; Kvaal, K.; Olsen, E.; Søndenå, R.

    2013-11-15

    Crystal imperfections limit the efficiency of multicrystalline silicon solar cells. Recombination through traps is more prominent in areas with high density of crystal imperfections. A method to visualize the distribution of radiative emission from Shockley Read Hall recombination in silicon is demonstrated. We use hyperspectral photoluminescence, a fast non-destructive method, to image radiatively active recombination processes on a set of 50 wafers through a silicon block. The defect related emission lines D1 and D2 may be detected together or alone. The D3 and D4 seem to be correlated if we assume that an emission at the similar energy as D3 (VID3) is caused by a separate mechanism. The content of interstitial iron (Fe{sub i}) correlates with D4. This method yields a spectral map of the inter band gap transitions, which opens up for a new way to characterize mechanisms related to loss of efficiency for solar cells processed from the block.

  16. Parametric Multi-Level Tiling of Imperfectly Nested Loops

    SciTech Connect

    Hartono, Albert; Baskaran, Muthu M.; Bastoul, Cedric; Cohen, Albert; Krishnamoorthy, Sriram; Norris, Boyana; Ramanujam, J.; Sadayappan, Ponnuswamy

    2009-05-18

    Tiling is a critical loop transformation for generating high-performance code on modern architectures. Efficient generation of multilevel tiled code is essential to exploit several levels of parallelism and/or to maximize data reuse in deep memory hierarchies. Tiled loops with parameterized tile sizes (not compile time constants) facilitate runtime feedback and dynamic optimizations used in iterative compilation and automatic tuning. The existing parametric multilevel tiling approach has focused on transformation for perfectly nested loops, where all assignment statements are contained inside the innermost loop of a loop nest. Previous solutions to tiling for imperfect loop nests are limited to the case where tile sizes are fixed. In this paper, we present an approach to parameterized multilevel tiling for imperfectly nested loops. Our tiling algorithm generates loops that iterate over full rectangular tiles that are amenable for potential compiler optimizations such as register tiling. Experimental results using a number of computational benchmarks demonstrate the effectiveness of our tiling approach.

  17. Effects of mask imperfections on InP etching profiles

    SciTech Connect

    Huo, D.T.C.; Yan, M.F.; Wynn, J.D.; Wilt, D.P. )

    1990-01-01

    The authors have demonstrated that the quality of etch masks has a significant effect on the InP etching profiles. In particular, the authors have shown that mask imperfections can cause defective etching profiles, such as vertical sidewalls and extra mask undercutting in InP. The authors also discovered that the geometry of these defective profiles is determined by the orientation of the substrate relative to the direction of the mask imperfections. Along a {l angle}110{r angle} line mask defect, the downward etching process changes the {l angle}110{r angle} v-grooves to vertical sidewalls without extra undercutting. For v-grooves aligned along the {l angle}110{r angle} direction, defects on the mask give a significant extra undercutting without changing the etching profile.

  18. Stability, vibration and passive damping of partially restrained imperfect columns

    NASA Technical Reports Server (NTRS)

    Razzaq, Z.; Voland, R. T.; Bush, H. G.; Mikulas, M. M., Jr.

    1983-01-01

    A theoretical and experimental study of slender tubular columns for possible use in space structures is conducted in the presence of partial rotational end restraints. Explicit formulas are derived for computing the buckling load and the lowest natural frequency of perfectly straight uniform elastic members with rotational end restraints possessing linear moment-rotation characteristics. An exact solution in the form of a transcendental equation, and a numerical solution using second-order finite-differences are also presented. The presence of an initial imperfection is also incorporated into the numerical procedure. Vibration tests are conducted on an imperfect tubular steel member in the absence of an axial load. A damping concept consisting of a string-mass assembly is explored. Three passive damping configurations involving combinations of three lead shots were investigated. The three lead shot configurations provided considerably greater damping than the single lead shot.

  19. Coarse grain modeling of imperfect networks and gels

    NASA Astrophysics Data System (ADS)

    Sliozberg, Yelena; Chantawansri, Tanya; Sirk, Timothy; Andzelm, Jan; Mrozek, Randy; Lenhart, Joseph

    2013-03-01

    There is a strong interest in chemically and physically cross-linked entangled polymer networks and gels due to their tailorability in respect to both mechanical and structural properties. Even so, these properties are sensitive to imperfections in the polymer networks, such as dangling ends and loops. Computational modeling is a viable tool to understand the effects of these imperfections on properties in a controlled environment, in which specific defects can be systematically created and varied. In this study, we have employed generic bead-spring models of flexible chains to study a chemically and physically cross-linked network. Our results will show the importance defects, such as dangling ends and loops, on the mechanical and structural properties of these networks. We will also discuss the effects of these defects on the time-dependent elastic modulus. The simulation results qualitatively agree with experimental results and the other theoretical predictions.

  20. Effects of instrument imperfections on quantitative scanning transmission electron microscopy.

    PubMed

    Krause, Florian F; Schowalter, Marco; Grieb, Tim; Müller-Caspary, Knut; Mehrtens, Thorsten; Rosenauer, Andreas

    2016-02-01

    Several instrumental imperfections of transmission electron microscopes are characterized and their effects on the results of quantitative scanning electron microscopy (STEM) are investigated and quantified using simulations. Methods to either avoid influences of these imperfections during acquisition or to include them in reference calculations are proposed. Particularly, distortions inflicted on the diffraction pattern by an image-aberration corrector can cause severe errors of more than 20% if not accounted for. A procedure for their measurement is proposed here. Furthermore, afterglow phenomena and nonlinear behavior of the detector itself can lead to incorrect normalization of measured intensities. Single electrons accidentally impinging on the detector are another source of error but can also be exploited for threshold-less calibration of STEM images to absolute dose, incident beam current determination and measurement of the detector sensitivity. PMID:26686661

  1. Imperfect Geometric Control and Overdamping for The Damped Wave Equation

    NASA Astrophysics Data System (ADS)

    Burq, Nicolas; Christianson, Hans

    2015-05-01

    We consider the damped wave equation on a manifold with imperfect geometric control. We show the sub-exponential energy decay estimate in (Christianson, J Funct Anal 258(3):1060-1065, 2010) is optimal in the case of one hyperbolic periodic geodesic. We show if the equation is overdamped, then the energy decays exponentially. Finally we show if the equation is overdamped but geometric control fails for one hyperbolic periodic geodesic, then nevertheless the energy decays exponentially.

  2. Buckling of structures with uncertain imperfections - Personal perspective

    NASA Technical Reports Server (NTRS)

    Elishakoff, Isaac

    1998-01-01

    The previous review on stochastic buckling of structures was written by Amazigo in 1976. This review summarizes some of the developments which took place in recent two decades. A brief overview is given of the effect on uncertainty in the initial geometric imperfections, elastic moduli, applied forces, and thickness variation. For the benefit of the thinking reader, the review has a critical nature. It should be noted that this manuscript has yet to be completed.

  3. Heavy quarkonium: progress, puzzles, and opportunities

    SciTech Connect

    Brambilla, N; Heltsley, B K; Vogt, R; Bodwin, G T; Eichten, E; Frawley, A D; Meyer, A B; Mitchell, R E; Papdimitriou, V; Petreczky, P; Petrov, A A; Robbe, P; Vairo, A; Andronic, A; Arnaldi, R; Artoisenet, P; Bali, G; Bertolin, A; Bettoni, D; Brodzicka, J; Bruno, G E; Caldwell, A; Catmore, J; Chang, C -H; Chao, K -T; Chudakov, E; Cortese, P; Crochet, P; Drutskoy, A; Ellwanger, U; Faccioli, P; Gabareen Mokhtar, A; Garcia i Tormo, X; Hanhart, C; Harris, F A; Kaplan, D M; Klein, S R; Kowalski, H; Lansberg, J -P; Levichev, E; Lombardo, V; Loureno, C; Maltoni, F; Mocsy, A; Mussa, R; Navarra, F S; Negrini, M; Nielsen, M; Olsen, S L; Pakhlov, P; Pakhlova, G; Peters, K; Polosa, A D; Qian, W; Qiu, J -W; Rong, G; Sanchis-Lozano, M A; Scomparin, E; Senger, P; Simon, F; Stracka, S; Sumino, Y; Voloshin, M; Weiss, C; Wohri, H K; Yuan, C -Z

    2011-02-01

    A golden age for heavy quarkonium physics dawned a decade ago, initiated by the confluence of exciting advances in quantum chromodynamics (QCD) and an explosion of related experimental activity. The early years of this period were chronicled in the Quarkonium Working Group (QWG) CERN Yellow Report (YR) in 2004, which presented a comprehensive review of the status of the field at that time and provided specific recommendations for further progress. However, the broad spectrum of subsequent breakthroughs, surprises, and continuing puzzles could only be partially anticipated. Since the release of the YR, the BESII program concluded only to give birth to BESIII; the $B$-factories and CLEO-c flourished; quarkonium production and polarization measurements at HERA, JLab, and the Tevatron matured; and heavy-ion collisions at RHIC have opened a window on the deconfinement regime. All these experiments leave legacies of quality, precision, and unsolved mysteries for quarkonium physics, and therefore beg for continuing investigations. The plethora of newly-found quarkonium-like states unleashed a flood of theoretical investigations into new forms of matter such as quark-gluon hybrids, mesonic molecules, and tetraquarks. Measurements of the spectroscopy, decays, production, and in-medium behavior of c\\bar{c}, b\\bar{b}, and b\\bar{c} bound states have been shown to validate some theoretical approaches to QCD and highlight lack of quantitative success for others. The intriguing details of quarkonium suppression in heavy-ion collisions that have emerged from RHIC have elevated the importance of separating hot- and cold-nuclear-matter effects in quark-gluon plasma studies. This review systematically addresses all these matters and concludes by prioritizing directions for ongoing and future efforts.

  4. Heavy quarkonium: progress, puzzles, and opportunities

    SciTech Connect

    Petreczky, P.; Brambilla, N.; Eidelman,S; B.K. Heltsley; Vogt, R.; Bodwiny, G.T.; Eichteny, E., et. al.

    2011-02-08

    A golden age for heavy quarkonium physics dawned a decade ago, initiated by the confluence of exciting advances in quantum chromodynamics (QCD) and an explosion of related experimental activity. The early years of this period were chronicled in the Quarkonium Working Group (QWG) CERN Yellow Report (YR) in 2004, which presented a comprehensive review of the status of the field at that time and provided specific recommendations for further progress. However, the broad spectrum of subsequent breakthroughs, surprises, and continuing puzzles could only be partially anticipated. Since the release of the YR, the BESII program concluded only to give birth to BESIII; the $B$-factories and CLEO-c flourished; quarkonium production and polarization measurements at HERA and the Tevatron matured; and heavy-ion collisions at RHIC have opened a window on the deconfinement regime. All these experiments leave legacies of quality, precision, and unsolved mysteries for quarkonium physics, and therefore beg for continuing investigations. The plethora of newly-found quarkonium-like states unleashed a flood of theoretical investigations into new forms of matter such as quark-gluon hybrids, mesonic molecules, and tetraquarks. Measurements of the spectroscopy, decays, production, and in-medium behavior of c{bar c}, b{bar b}, and b{bar c} bound states have been shown to validate some theoretical approaches to QCD and highlight lack of quantitative success for others. The intriguing details of quarkonium suppression in heavy-ion collisions that have emerged from RHIC have elevated the importance of separating hot- and cold-nuclear-matter effects in quark-gluon plasma studies. This review systematically addresses all these matters and concludes by prioritizing directions for ongoing and future efforts.

  5. Transitional Flows in Imperfect Millimeter-Scale Channels

    NASA Astrophysics Data System (ADS)

    Lissandrello, Charles; Li, Le; Ekinci, Kamil L.; Yakhot, Victor

    2015-11-01

    The majority of workers studying transition to turbulence in pipes have been interested in the flow response to perturbations in otherwise perfect pipes. Conversely, the ``fuzzy'' problem involving inlet disturbances, pipe imperfections, and pipe roughness has not attracted as much attention. Here, we investigate both experimentally and theoretically the transition to turbulence in imperfect millimeter-scale channels. For probing the flows, we use microcantilever sensors embedded in the channel walls. We perform experiments in two nominally identical channels. We quantify growing perturbations near the channel wall by their spectra and statistical properties, including probability densities and low- and high-order moments. The different sets of imperfections in the two channels result in two random flows in which the high-order moments of the near-wall fluctuations differ by orders of magnitude. Surprisingly, however, the lowest-order statistics in both cases appear to be qualitatively similar and can be described by a proposed noisy Landau equation for a slow mode. The noise, regardless of its origin, regularizes the Landau singularity of the relaxation time and makes transitions driven by different noise sources appear similar.

  6. International trade network: fractal properties and globalization puzzle.

    PubMed

    Karpiarz, Mariusz; Fronczak, Piotr; Fronczak, Agata

    2014-12-12

    Globalization is one of the central concepts of our age. The common perception of the process is that, due to declining communication and transport costs, distance becomes less and less important. However, the distance coefficient in the gravity model of trade, which grows in time, indicates that the role of distance increases rather than decreases. This, in essence, captures the notion of the globalization puzzle. Here, we show that the fractality of the international trade system (ITS) provides a simple solution for the puzzle. We argue that the distance coefficient corresponds to the fractal dimension of ITS. We provide two independent methods, the box counting method and spatial choice model, which confirm this statement. Our results allow us to conclude that the previous approaches to solving the puzzle misinterpreted the meaning of the distance coefficient in the gravity model of trade. PMID:25541810

  7. The Puzzle of Science; Making Sense of Incomplete Information

    NASA Astrophysics Data System (ADS)

    Shorey, B. U.

    2015-12-01

    There are many topics within Earth science including evolution, historical geology, and climate change, which have gained the status of theory becuse they have overwhelming evidence, yet there is still fragmentary information which can frustrate a student from coming to solid conclusions. Using a jigsaw puzzle whose image has been hidden, and the pieces only given out sparingly, students go though the process of getting more information. How does one get more puzzle pieces and what is the interpretive process? Experience with this exercise demonstrates how students can sketch out an incredibly accurate conception of the "big picture", despite not having all the puzzle pieces. The goal of this talk is to give a complete tool kit to perform as a comprehensive lesson plan. Guiding questions and copies of lesson plans and materials are supplied for this exercise.

  8. International Trade Network: Fractal Properties and Globalization Puzzle

    NASA Astrophysics Data System (ADS)

    Karpiarz, Mariusz; Fronczak, Piotr; Fronczak, Agata

    2014-12-01

    Globalization is one of the central concepts of our age. The common perception of the process is that, due to declining communication and transport costs, distance becomes less and less important. However, the distance coefficient in the gravity model of trade, which grows in time, indicates that the role of distance increases rather than decreases. This, in essence, captures the notion of the globalization puzzle. Here, we show that the fractality of the international trade system (ITS) provides a simple solution for the puzzle. We argue that the distance coefficient corresponds to the fractal dimension of ITS. We provide two independent methods, the box counting method and spatial choice model, which confirm this statement. Our results allow us to conclude that the previous approaches to solving the puzzle misinterpreted the meaning of the distance coefficient in the gravity model of trade.

  9. The Computational Complexity of the Kakuro Puzzle, Revisited

    NASA Astrophysics Data System (ADS)

    Ruepp, Oliver; Holzer, Markus

    We present a new proof of NP-completeness for the problem of solving instances of the Japanese pencil puzzle Kakuro (also known as Cross-Sum). While the NP-completeness of Kakuro puzzles has been shown before [T. Seta. The complexity of CROSS SUM. IPSJ SIG Notes, AL-84:51-58, 2002], there are still two interesting aspects to our proof: we show NP-completeness for a new variant of Kakuro that has not been investigated before and thus improves the aforementioned result. Moreover some parts of the proof have been generated automatically, using an interesting technique involving SAT solvers.

  10. Finding optimal solutions to the twenty-four puzzle

    SciTech Connect

    Korf, R.E.; Taylor, L.A.

    1996-12-31

    We have found the first optimal solutions to random instances of the Twenty-Four Puzzle, the 5 x 5 version of the well-known sliding-tile puzzles. Our new contribution to this problem is a more powerful admissible heuristic function. We present a general theory for the automatic discovery of such heuristics, which is based on considering multiple subgoals simultaneously. In addition, we apply a technique for pruning duplicate nodes in depth-first search using a finite-state machine. Finally, we observe that as heuristic search problems are scaled up, more powerful heuristic functions become both necessary and cost-effective.

  11. Reliability with imperfect diagnostics. [flight-maintenance sequence

    NASA Technical Reports Server (NTRS)

    White, A. L.

    1983-01-01

    A reliability estimation method for systems that continually accumulate faults because of imperfect diagnostics is developed and an application for redundant digital avionics is presented. The present method assumes that if a fault does not appear in a short period of time, it will remain hidden until a majority of components are faulty and the system fails. A certain proportion of a component's faults are detected in a short period of time, and a description of their detection is included in the reliability model. A Markov model of failure during flight for a nonreconfigurable five-plex is presented for a sequence of one-hour flights followed by maintenance.

  12. Security Issues of Quantum Cryptographic Systems with Imperfect Detectors

    NASA Astrophysics Data System (ADS)

    Burenkov, Viacheslav

    The laws of quantum physics can be used to secure communications between two distant parties in a scheme called quantum key distribution (QKD), even against a technologically unlimited eavesdropper. While the theoretical security of QKD has been proved rigorously, current implementations of QKD are generally insecure. In particular, mathematical models of devices, such as detectors, do not accurately describe their reallife behaviour. Such seemingly insignificant discrepancies can compromise the security of the entire scheme, especially as novel detector technologies are being developed with little regard for potential vulnerabilities. In this thesis, we study how detector imperfections can impact the security of QKD and how to overcome such technological limitations. (Abstract shortened by UMI.).

  13. Heavy quarkonium : progress, puzzles, and opportunities.

    SciTech Connect

    Brambilla, N.; Eidelman, S.; Heltsley, B. K.; Vogt, R.; Bodwin, G. T.; Quarkonium Working Group; High Energy Physics; Technische Univ. Munchen; Budker Inst. of Nuclear Physics; Cornell Univ.; LLNL; Univ. of California at Davis

    2011-01-01

    A golden age for heavy-quarkonium physics dawned a decade ago, initiated by the confluence of exciting advances in quantum chromodynamics (QCD) and an explosion of related experimental activity. The early years of this period were chronicled in the Quarkonium Working Group (QWG) CERN Yellow Report (YR) in 2004, which presented a comprehensive review of the status of the field at that time and provided specific recommendations for further progress. However, the broad spectrum of subsequent breakthroughs, surprises, and continuing puzzles could only be partially anticipated. Since the release of the YR, the BESII program concluded only to give birth to BESIII; the B-factories and CLEO-c flourished; quarkonium production and polarization measurements at HERA and the Tevatron matured; and heavy-ion collisions at RHIC have opened a window on the deconfinement regime. All these experiments leave legacies of quality, precision, and unsolved mysteries for quarkonium physics, and therefore beg for continuing investigations at BESIII, the LHC, RHIC, FAIR, the Super Flavor and/or Tau-Charm factories, JLab, the ILC, and beyond. The list of newly found conventional states expanded to include h{sub c}(1P), {chi}{sub c2} (2P), B{sub c}{sup +}, and {eta}{sub b} (1S). In addition, the unexpected and still-fascinating X(3872) has been joined by more than a dozen other charmonium- and bottomonium-like 'XYZ' states that appear to lie outside the quark model. Many of these still need experimental confirmation. The plethora of new states unleashed a flood of theoretical investigations into new forms of matter such as quark-gluon hybrids, mesonic molecules, and tetraquarks. Measurements of the spectroscopy, decays, production, and in-medium behavior of c{bar c}, b{bar b}, and b{bar c} bound states have been shown to validate some theoretical approaches to QCD and highlight lack of quantitative success for others. Lattice QCD has grown from a tool with computational possibilities to an

  14. Effect of imperfect Faraday mirrors on the security of a Faraday-Michelson quantum cryptography system

    NASA Astrophysics Data System (ADS)

    Wang, Wei-Long; Gao, Ming; Ma, Zhi

    2013-11-01

    The one-way Faraday-Michelson system is a very useful practical quantum cryptography system where Faraday mirrors (FMs) play an important role. In this paper we analyze the security of this system against imperfect FMs. We consider the security loophole caused by imperfect FMs in Alice’s and Bob’s security zones. Then we implement a passive FM attack in this system. By changing the values of the imperfection parameters of Alice’s FMs, we calculate the quantum bit error rate between Alice and Bob induced by Eve and the probability that Eve obtains outcomes successfully. It is shown that the imperfection of one of Alice’s two FMs makes the system sensitive to an attack. Finally we give a modified key rate as a function of the FM imperfections. The security analysis indicates that both Alice’s and Bob’s imperfect FMs can compromise the secure key.

  15. One-dimensional flows of an imperfect diatomic gas

    NASA Technical Reports Server (NTRS)

    1959-01-01

    With the assumptions that Berthelot's equation of state accounts for molecular size and intermolecular force effects, and that changes in the vibrational heat capacities are given by a Planck term, expressions are developed for analyzing one-dimensional flows of a diatomic gas. The special cases of flow through normal and oblique shocks in free air at sea level are investigated. It is found that up to a Mach number 10 pressure ratio across a normal shock differs by less than 6 percent from its ideal gas value; whereas at Mach numbers above 4 the temperature rise is considerable below and hence the density rise is well above that predicted assuming ideal gas behavior. It is further shown that only the caloric imperfection in air has an appreciable effect on the pressures developed in the shock process considered. The effects of gaseous imperfections on oblique shock-flows are studied from the standpoint of their influence on the life and pressure drag of a flat plate operating at Mach numbers of 10 and 20. The influence is found to be small. (author)

  16. Efficient Logistic Regression Designs Under an Imperfect Population Identifier

    PubMed Central

    Albert, Paul S.; Liu, Aiyi; Nansel, Tonja

    2013-01-01

    Summary Motivated by actual study designs, this article considers efficient logistic regression designs where the population is identified with a binary test that is subject to diagnostic error. We consider the case where the imperfect test is obtained on all participants, while the gold standard test is measured on a small chosen subsample. Under maximum-likelihood estimation, we evaluate the optimal design in terms of sample selection as well as verification. We show that there may be substantial efficiency gains by choosing a small percentage of individuals who test negative on the imperfect test for inclusion in the sample (e.g., verifying 90% test-positive cases). We also show that a two-stage design may be a good practical alternative to a fixed design in some situations. Under optimal and nearly optimal designs, we compare maximum-likelihood and semi-parametric efficient estimators under correct and misspecified models with simulations. The methodology is illustrated with an analysis from a diabetes behavioral intervention trial. PMID:24261471

  17. Population level impact of an imperfect prophylactic HSV-2 vaccine

    PubMed Central

    Alsallaq, Ramzi A.; Schiffer, Joshua T.; Longini, Ira M.; Wald, Anna; Corey, Lawrence; Abu-Raddad, Laith J.

    2010-01-01

    Background The continuation of developing HSV-2 prophylactic vaccines requires parallel mathematical modeling to quantify the impact on the population of these vaccines. Methods Using mathematical modeling we derived three summary measures for the population impact of imperfect HSV-2 vaccines as a function of their efficacies in reducing susceptibility (VES), genital shedding (VEP), and infectivity during shedding (VEI). In addition, we studied the population level impact of vaccine intervention using representative vaccine efficacies. Results A vaccine with limited efficacy of reducing shedding frequency (VEP =10%) and infectivity (VEI =0%) would need to reduce susceptibility by 75% (VES =75%) to substantially reduce the sustainability of HSV-2 infection in a population. No reduction in susceptibility would be required to reach this target in a vaccine that decreased shedding by 75% (VES =0%, VEP =75%, VEI =0%). Mass vaccination using a vaccine with imperfect efficacies (VES =30%, VEP =75%, and VEI =0%) in Kisumu, Kenya in 2010 would decrease prevalence and incidence in 2020 by 7% and 30% respectively. For lower prevalence settings, vaccination is predicted to have a lower impact on prevalence. Conclusion A vaccine with substantially high efficacy of reducing HSV-2 shedding frequency would have a desirable impact at the population level. The vaccine’s short-term impact in a high prevalence setting in Africa would be a substantial decrease in incidence, whereas its immediate impact on prevalence would be small and would increase slowly over time. PMID:20351622

  18. Identifying sediment discontinuities and solving dating puzzles using monitoring and palaeolimnological records

    NASA Astrophysics Data System (ADS)

    Dong, Xuhui; Sayer, Carl D.; Bennion, Helen; Maberly, Stephen C.; Yang, Handong; Battarbee, Richard W.

    2016-05-01

    Palaeolimnological studies should ideally be based upon continuous, undisturbed sediment sequences with reliable chronologies. However for some lake cores, these conditions are not met and palaeolimnologists are often faced with dating puzzles caused by sediment disturbances in the past. This study chooses Esthwaite Water from England to illustrate how to identify sedimentation discontinuities in lake cores and how chronologies can be established for imperfect cores by correlation of key sediment signatures in parallel core records and with long-term monitoring data (1945-2003). Replicated short cores (ESTH1, ESTH7, and ESTH8) were collected and subjected to loss-on-ignition, radiometric dating (210Pb, 137Cs, and 14C), particle size, trace metal, and fossil diatom analysis. Both a slumping and a hiatus event were detected in ESTH7 based on comparisons made between the cores and the long-term diatom data. Ordination analysis suggested that the slumped material in ESTH7 originated from sediment deposited around 1805-1880 AD. Further, it was inferred that the hiatus resulted in a loss of sediment deposited from 1870 to 1970 AD. Given the existence of three superior 14C dates in ESTH7, ESTH1 and ESTH7 were temporally correlated by multiple palaeolimnological proxies for age-depth model development. High variability in sedimentation rates was evident, but good agreement across the various palaeolimnological proxies indicated coherence in sediment processes within the coring area. Differences in sedimentation rates most likely resulted from the natural morphology of the lake basin. Our study suggests that caution is required in selecting suitable coring sites for palaeolimnological studies of small, relatively deep lakes and that proximity to steep slopes should be avoided wherever possible. Nevertheless, in some cases, comparisons between a range of contemporary and palaeolimnological records can be employed to diagnose sediment disturbances and establish a chronology.

  19. An Analysis of Instructor-Created Crossword Puzzles for Student Review

    ERIC Educational Resources Information Center

    Weisskirch, Robert S.

    2006-01-01

    This article evaluates the use of instructor-created crossword puzzles as a means of reviewing course material. Students completed one crossword puzzle in class to prepare for an exam, and then they had the opportunity to complete a second crossword puzzle outside of class to prepare for the second exam. Students generally rated the crossword…

  20. Teaching Proofs and Algorithms in Discrete Mathematics with Online Visual Logic Puzzles

    ERIC Educational Resources Information Center

    Cigas, John; Hsin, Wen-Jung

    2005-01-01

    Visual logic puzzles provide a fertile environment for teaching multiple topics in discrete mathematics. Many puzzles can be solved by the repeated application of a small, finite set of strategies. Explicitly reasoning from a strategy to a new puzzle state illustrates theorems, proofs, and logic principles. These provide valuable, concrete…

  1. On the puzzling distribution of cholesterol in the plasma membrane.

    PubMed

    Giang, H; Schick, M

    2016-09-01

    The distribution of cholesterol between the two leaves of the plasma membrane in mammalian cells presents a conundrum; given cholesterol's known affinity for sphingomyelin, which resides predominantly in the exoplasmic leaf, why is it that experiment finds a majority of the cholesterol in the cytoplasmic leaf? This article reviews a recently proposed solution to this puzzle. PMID:26724709

  2. A Jigsaw Puzzle Approach To Learning History in Introductory Psychology.

    ERIC Educational Resources Information Center

    Krauss, Judith

    1999-01-01

    Believes that it may be daunting for some students to learn about the history of psychology. Describes a teaching strategy that uses jigsaw puzzles to teach about the historical terms of structuralism, functionalism, and gestalt psychology. Finds that students performed better on test questions related to these three concepts after using this…

  3. Generating Sudoku Puzzles and Its Applications in Teaching Mathematics

    ERIC Educational Resources Information Center

    Evans, Ryan; Lindner, Brett; Shi, Yixun

    2011-01-01

    This article presents a few methods for generating Sudoku puzzles. These methods are developed based on the concepts of matrix, permutation, and modular functions, and therefore can be used to form application examples or student projects when teaching various mathematics courses. Mathematical properties of these methods are studied, connections…

  4. Crossword Puzzles as a Learning Tool for Vocabulary Development

    ERIC Educational Resources Information Center

    Orawiwatnakul, Wiwat

    2013-01-01

    Introduction: Since vocabulary is a key basis on which reading achievement depends, various vocabulary acquisition techniques have become pivotal. Among the many teaching approaches, traditional or otherwise, the use of crossword puzzles seems to offer potential and a solution for the problem of learning vocabulary. Method: This study was…

  5. Unraveling "Braid": Puzzle Games and Storytelling in the Imperative Mood

    ERIC Educational Resources Information Center

    Arnott, Luke

    2012-01-01

    "Unraveling Braid" analyzes how unconventional, non-linear narrative fiction can help explain the ways in which video games signify. Specifically, this essay looks at the links between the semiotic features of Jonathan Blow's 2008 puzzle-platform video game Braid and similar elements in Georges Perec's 1978 novel "Life A User's Manual," as well as…

  6. To Txt or Not to Txt: That's the Puzzle

    ERIC Educational Resources Information Center

    Goh, Tiong-Thye; Hooper, Val

    2007-01-01

    This paper describes the potential use of a mobile phone Short Message Service (SMS) crossword puzzle system to promote interaction through learning activities in a large classroom environment. While personal response systems (PRS) have been used in the classroom environment to foster interaction, it is not an ideal tool with respect to cost and…

  7. Using Building-Block Puzzles to Practice Drawing Organic Mechanisms

    ERIC Educational Resources Information Center

    Erdik, Ender

    2005-01-01

    A study uses a thought-provoking, pencil-and-paper activity to aid students in writing organic reaction mechanisms. Organic and functional groups that constitute the formulas of organic and inorganic reactants, ionic intermediates, and products are presented as building blocks, which must be placed correctly in a given puzzle so that they bind…

  8. Imperfect traveling chimera states induced by local synaptic gradient coupling

    NASA Astrophysics Data System (ADS)

    Bera, Bidesh K.; Ghosh, Dibakar; Banerjee, Tanmoy

    2016-07-01

    In this paper, we report the occurrence of chimera patterns in a network of neuronal oscillators, which are coupled through local, synaptic gradient coupling. We discover a new chimera pattern, namely the imperfect traveling chimera state, where the incoherent traveling domain spreads into the coherent domain of the network. Remarkably, we also find that chimera states arise even for one-way local coupling, which is in contrast to the earlier belief that only nonlocal, global, or nearest-neighbor local coupling can give rise to chimera state; this find further relaxes the essential connectivity requirement of getting a chimera state. We choose a network of identical bursting Hindmarsh-Rose neuronal oscillators, and we show that depending upon the relative strength of the synaptic and gradient coupling, several chimera patterns emerge. We map all the spatiotemporal behaviors in parameter space and identify the transitions among several chimera patterns, an in-phase synchronized state, and a global amplitude death state.

  9. Imperfect traveling chimera states induced by local synaptic gradient coupling.

    PubMed

    Bera, Bidesh K; Ghosh, Dibakar; Banerjee, Tanmoy

    2016-07-01

    In this paper, we report the occurrence of chimera patterns in a network of neuronal oscillators, which are coupled through local, synaptic gradient coupling. We discover a new chimera pattern, namely the imperfect traveling chimera state, where the incoherent traveling domain spreads into the coherent domain of the network. Remarkably, we also find that chimera states arise even for one-way local coupling, which is in contrast to the earlier belief that only nonlocal, global, or nearest-neighbor local coupling can give rise to chimera state; this find further relaxes the essential connectivity requirement of getting a chimera state. We choose a network of identical bursting Hindmarsh-Rose neuronal oscillators, and we show that depending upon the relative strength of the synaptic and gradient coupling, several chimera patterns emerge. We map all the spatiotemporal behaviors in parameter space and identify the transitions among several chimera patterns, an in-phase synchronized state, and a global amplitude death state. PMID:27575131

  10. Clinical trials: robust tests are wonderful for imperfect data.

    PubMed

    Cleophas, Ton J

    2015-01-01

    Robust tests are tests that can handle the inclusion into a data file of some outliers without largely changing the overall test results. Despite the risk of non-Gaussian data in clinical trials, robust tests are virtually never performed. The objective of this study was to review important robust tests and to assess whether they provide better sensitivity of testing than standard tests do. In a 33 patient study of frailty scores, no significant t value was obtained (P = 0.067). The following 4 robust tests were performed: (1) z test for medians and median absolute deviations, (2) z test for Winsorized variances, (3) Mood test, and (4) z test for M-estimators with bootstrap standard errors. They produced P values of, respectively, <0.0001, 0.043, <0.0001, and 0.005. Robust tests are wonderful for imperfect clinical data because they often produce statistically significant results, whereas standard tests do not. PMID:23896742

  11. Generalized random sign and alert delay models for imperfect maintenance.

    PubMed

    Dijoux, Yann; Gaudoin, Olivier

    2014-04-01

    This paper considers the modelling of the process of Corrective and condition-based Preventive Maintenance, for complex repairable systems. In order to take into account the dependency between both types of maintenance and the possibility of imperfect maintenance, Generalized Competing Risks models have been introduced in "Doyen and Gaudoin (J Appl Probab 43:825-839, 2006)". In this paper, we study two classes of these models, the Generalized Random Sign and Generalized Alert Delay models. A Generalized Competing Risks model can be built as a generalization of a particular Usual Competing Risks model, either by using a virtual age framework or not. The models properties are studied and their parameterizations are discussed. Finally, simulation results and an application to real data are presented. PMID:23460491

  12. Long-distance quantum key distribution with imperfect devices

    SciTech Connect

    Lo Piparo, Nicoló; Razavi, Mohsen

    2014-12-04

    Quantum key distribution over probabilistic quantum repeaters is addressed. We compare, under practical assumptions, two such schemes in terms of their secure key generation rate per memory, R{sub QKD}. The two schemes under investigation are the one proposed by Duan et al. in [Nat. 414, 413 (2001)] and that of Sangouard et al. proposed in [Phys. Rev. A 76, 050301 (2007)]. We consider various sources of imperfections in the latter protocol, such as a nonzero double-photon probability for the source, dark count per pulse, channel loss and inefficiencies in photodetectors and memories, to find the rate for different nesting levels. We determine the maximum value of the double-photon probability beyond which it is not possible to share a secret key anymore. We find the crossover distance for up to three nesting levels. We finally compare the two protocols.

  13. Casimir force induced by an imperfect Bose gas.

    PubMed

    Napiórkowski, Marek; Piasecki, Jarosław

    2011-12-01

    We present a study of the Casimir effect in an imperfect (mean-field) Bose gas contained between two infinite parallel plane walls. The derivation of the Casimir force follows from the calculation of the excess grand-canonical free energy density under periodic, Dirichlet, and Neumann boundary conditions with the use of the steepest descent method. In the one-phase region, the force decays exponentially fast when distance D between the walls tends to infinity. When the Bose-Einstein condensation point is approached, the decay length in the exponential law diverges with critical exponent ν(IMP) = 1, which differs from the perfect gas case where ν(P) = 1/2. In the two-phase region, the Casimir force is long range and decays following the power law D(-3), with the same amplitude as in the perfect gas. PMID:22304038

  14. FEL gain calculation for imperfectly matched electron beams

    NASA Astrophysics Data System (ADS)

    Swent, R. L.; Berryman, K. W.

    1995-04-01

    We present here the details of an analytical small-signal gain calculation. The analysis builds on the basic one-dimensional analytical calculation by modeling the effects of finite electron beam size and imperfect matching of the electron beam to the wiggler. The calculation uses TRANSPORT [SLAC-91, Rev. 2 (1977)] parameters to describe the electron beam in order to easily take the output of beam transport calculations and use them as the input for FEL gain calculations. The model accepts an arbitrary TRANSPORT beam and includes the effects of energy spread, beam size, betatron oscillations, and focussing in the wiggle plane. The model has allowed us to calculate the range over which our FEL can be tuned by changing the electron energy alone (i.e., without changing any magnets).

  15. Loss-tolerant quantum cryptography with imperfect sources

    NASA Astrophysics Data System (ADS)

    Tamaki, Kiyoshi; Curty, Marcos; Kato, Go; Lo, Hoi-Kwong; Azuma, Koji

    2014-11-01

    In principle, quantum key distribution (QKD) offers unconditional security based on the laws of physics. Unfortunately, all previous QKD experiments assume perfect state preparation in their security analysis. Therefore, the generated key is not proven to be secure in the presence of unavoidable modulation errors. The key reason that modulation errors are not considered in previous QKD experiments lies in a crucial weakness of the standard Gottesman-Lo-Lütkenhaus-Preskill (GLLP) model, namely, it is not loss tolerant and Eve may in principle enhance imperfections through losses. Here, we propose a QKD protocol that is loss tolerant to state preparation flaws. Importantly, we show conclusively that the state preparation process in QKD can be much less precise than initially thought. Our method can also be applied to other quantum cryptographic protocols.

  16. Effects of experimental imperfections on a spin counting experiment.

    PubMed

    Zelenova, Yelena; Morgan, Steven W; Boutis, Gregory S

    2013-06-01

    Spin counting NMR is an experimental technique that allows a determination of the size and time evolution of networks of dipolar coupled nuclear spins. This work reports on an average Hamiltonian treatment of two spin counting sequences and compares the efficiency of the two cycles in the presence of flip errors, RF inhomogeneity, phase transients, phase errors, and offset interactions commonly present in NMR experiments. Simulations on small quantum systems performed using the two cycles reveal the effects of pulse imperfections on the resulting multiple quantum spectra, in qualitative agreement with the average Hamiltonian calculations. Experimental results on adamantane are presented, demonstrating differences in the two sequences in the presence of pulse errors. PMID:23648319

  17. How to Introduce the Imperfection Sensitivity Concept into Design 2

    NASA Technical Reports Server (NTRS)

    Elishakoff, Isaac

    1998-01-01

    The previous review on stochastic buckling of structures was written by Amazigo in 1976. The present review summarizes some of the developments which took place in recent two decades. A brief overview is given of the effect on uncertainty in the initial geometric imperfections, elastic moduli, applied forces, and thickness variation. For the benefit of the thinking reader, the review has a critical nature. Present essay should be viewed as a direct continuation of our previous paper (1983) with the same title. In order not to repeat what was covered there, it appears instructive to read it although not necessarily prior to dwelling on this article. Accordingly the title is appended with the serial number. It is not promised that the third review will follow since the university science, both fortunately and unfortunately, stands on three things: relevance, interest, and grants.

  18. Aquaporins: another piece in the osmotic puzzle.

    PubMed

    Alleva, Karina; Chara, Osvaldo; Amodeo, Gabriela

    2012-09-21

    Osmolarity not only plays a key role in cellular homeostasis but also challenges cell survival. The molecular understanding of osmosis has not yet been completely achieved, and the discovery of aquaporins as molecular entities involved in water transport has caused osmosis to again become a focus of research. The main questions that need to be answered are the mechanism underlying the osmotic permeability coefficients and the extent to which aquaporins change our understanding of osmosis. Here, attempts to answer these questions are discussed. Critical aspects of the state of the state of knowledge on osmosis, a topic that has been studied since 19th century, are reviewed and integrated with the available information provided by in vivo, in vitro and in silico approaches. PMID:22728434

  19. Correcting length-frequency distributions for imperfect detection

    USGS Publications Warehouse

    Breton, André R.; Hawkins, John A.; Winkelman, Dana L.

    2013-01-01

    Sampling gear selects for specific sizes of fish, which may bias length-frequency distributions that are commonly used to assess population size structure, recruitment patterns, growth, and survival. To properly correct for sampling biases caused by gear and other sources, length-frequency distributions need to be corrected for imperfect detection. We describe a method for adjusting length-frequency distributions when capture and recapture probabilities are a function of fish length, temporal variation, and capture history. The method is applied to a study involving the removal of Smallmouth Bass Micropterus dolomieu by boat electrofishing from a 38.6-km reach on the Yampa River, Colorado. Smallmouth Bass longer than 100 mm were marked and released alive from 2005 to 2010 on one or more electrofishing passes and removed on all other passes from the population. Using the Huggins mark–recapture model, we detected a significant effect of fish total length, previous capture history (behavior), year, pass, year×behavior, and year×pass on capture and recapture probabilities. We demonstrate how to partition the Huggins estimate of abundance into length frequencies to correct for these effects. Uncorrected length frequencies of fish removed from Little Yampa Canyon were negatively biased in every year by as much as 88% relative to mark–recapture estimates for the smallest length-class in our analysis (100–110 mm). Bias declined but remained high even for adult length-classes (≥200 mm). The pattern of bias across length-classes was variable across years. The percentage of unadjusted counts that were below the lower 95% confidence interval from our adjusted length-frequency estimates were 95, 89, 84, 78, 81, and 92% from 2005 to 2010, respectively. Length-frequency distributions are widely used in fisheries science and management. Our simple method for correcting length-frequency estimates for imperfect detection could be widely applied when mark–recapture data

  20. OLD PUZZLE, NEW INSIGHTS: A LITHIUM-RICH GIANT QUIETLY BURNING HELIUM IN ITS CORE

    SciTech Connect

    Aguirre, V. Silva; Christensen-Dalsgaard, J.; Jessen-Hansen, J.; Ruchti, G. R.; Hekker, S.; Cassisi, S.; Datta, A.; Jendreieck, A.; Mazumdar, A.; Mosser, B.; Stello, D.; Beck, P. G.; De Ridder, J.

    2014-03-20

    About 1% of giant stars have been shown to have large surface Li abundances, which is unexpected according to standard stellar evolution models. Several scenarios for lithium production have been proposed, but it is still unclear why these Li-rich giants exist. A missing piece in this puzzle is the knowledge of the exact stage of evolution of these stars. Using low- and-high-resolution spectroscopic observations, we have undertaken a survey of lithium-rich giants in the Kepler field. In this Letter, we report the finding of the first confirmed Li-rich core-helium-burning giant, as revealed by asteroseismic analysis. The evolutionary timescales constrained by its mass suggest that Li production most likely took place through non-canonical mixing at the RGB tip, possibly during the helium flash.

  1. Analytical and numerical modeling of non-collinear shear wave mixing at an imperfect interface.

    PubMed

    Zhang, Ziyin; Nagy, Peter B; Hassan, Waled

    2016-02-01

    Non-collinear shear wave mixing at an imperfect interface between two solids can be exploited for nonlinear ultrasonic assessment of bond quality. In this study we developed two analytical models for nonlinear imperfect interfaces. The first model uses a finite nonlinear interfacial stiffness representation of an imperfect interface of vanishing thickness, while the second model relies on a thin nonlinear interphase layer to represent an imperfect interface region. The second model is actually a derivative of the first model obtained by calculating the equivalent interfacial stiffness of a thin isotropic nonlinear interphase layer in the quasi-static approximation. The predictions of both analytical models were numerically verified by comparison to COMSOL finite element simulations. These models can accurately predict the additional nonlinearity caused by interface imperfections based on the strength of the reflected and transmitted mixed longitudinal waves produced by them under non-collinear shear wave interrogation. PMID:26482394

  2. Parametric Study on the Response of Compression-Loaded Composite Shells With Geometric and Material Imperfections

    NASA Technical Reports Server (NTRS)

    Hilburger, Mark W.; Starnes, James H., Jr.

    2004-01-01

    The results of a parametric study of the effects of initial imperfections on the buckling and postbuckling response of three unstiffened thinwalled compression-loaded graphite-epoxy cylindrical shells with different orthotropic and quasi-isotropic shell-wall laminates are presented. The imperfections considered include initial geometric shell-wall midsurface imperfections, shell-wall thickness variations, local shell-wall ply-gaps associated with the fabrication process, shell-end geometric imperfections, nonuniform applied end loads, and variations in the boundary conditions including the effects of elastic boundary conditions. A high-fidelity nonlinear shell analysis procedure that accurately accounts for the effects of these imperfections on the nonlinear responses and buckling loads of the shells is described. The analysis procedure includes a nonlinear static analysis that predicts stable response characteristics of the shells and a nonlinear transient analysis that predicts unstable response characteristics.

  3. Analytical and numerical modeling of non-collinear shear wave mixing at an imperfect interface

    NASA Astrophysics Data System (ADS)

    Zhang, Ziyin; Nagy, Peter B.; Hassan, Waled

    2016-02-01

    Non-collinear shear wave mixing at an imperfect interface between two solids can be exploited for nonlinear ultrasonic assessment of bond quality. In this study we developed two analytical models for nonlinear imperfect interfaces. The first model uses a finite nonlinear interfacial stiffness representation of an imperfect interface of vanishing thickness, while the second model relies on a thin nonlinear interphase layer to represent an imperfect interface region. The second model is actually a derivative of the first model obtained by calculating the equivalent interfacial stiffness of a thin isotropic nonlinear interphase layer in the quasi-static approximation. The predictions of both analytical models were numerically verified by comparison to COMSOL finite element simulations. These models can accurately predict the excess nonlinearity caused by interface imperfections based on the strength of the reflected and transmitted mixed longitudinal waves produced by them under non-collinear shear wave interrogation.

  4. How to predict community responses to perturbations in the face of imperfect knowledge and network complexity

    USGS Publications Warehouse

    Aufderheide, Helge; Rudolf, Lars; Gross, Thilo; Lafferty, Kevin D.

    2013-01-01

    Recent attempts to predict the response of large food webs to perturbations have revealed that in larger systems increasingly precise information on the elements of the system is required. Thus, the effort needed for good predictions grows quickly with the system's complexity. Here, we show that not all elements need to be measured equally well, suggesting that a more efficient allocation of effort is possible. We develop an iterative technique for determining an efficient measurement strategy. In model food webs, we find that it is most important to precisely measure the mortality and predation rates of long-lived, generalist, top predators. Prioritizing the study of such species will make it easier to understand the response of complex food webs to perturbations.

  5. Impact of imperfect potential evapotranspiration knowledge on the efficiency and parameters of watershed models

    NASA Astrophysics Data System (ADS)

    Andréassian, Vazken; Perrin, Charles; Michel, Claude

    2004-01-01

    This paper attempts to assess the impact of improved estimates of areal potential evapotranspiration (PE) on the results of two rainfall-runoff models. A network of 42 PE stations was used for a sample of 62 watersheds and two watershed models of different complexity (the four-parameter GR4J model and an eight-parameter modified version of TOPMODEL), to test how sensitive rainfall-runoff models were to watershed PE estimated with the Penman equation. First, Penman PE estimates were regionalized in the Massif Central highlands of France, a mountainous area where PE is known to vary greatly with elevation, latitude, and longitude. The two watershed models were then used to assess changes in model efficiency with the improved PE input. Finally, the behavior of one of the model's parameters was analyzed, to understand how watershed models cope with systematic errors in the estimated PE input. In terms of model efficiency, in both models it was found that very simple assumptions on watershed PE input (the same average input for all watersheds) yield the same results as more accurate input obtained from regionalization. The detailed evaluation of the GR4J model calibrated with different PE input scenarios showed that the model is clearly sensitive to PE input, but that it uses its two production parameters to adapt to the various PE scenarios.

  6. Abortion in Vietnam: measurements, puzzles, and concerns.

    PubMed

    Goodkind, D

    1994-01-01

    This report summarizes current knowledge about abortion in Vietnam, drawing upon government statistics, survey data, and fieldwork undertaken by the author in Vietnam throughout 1993 and part of 1994. The official total abortion rate in Vietnam in 1992 was about 2.5 per woman, the highest in Asia and worrisome for a country with a still-high total fertility rate of 3.7 children per woman. Vietnamese provinces exhibited substantial variation in both the rate of abortion and the type of procedures performed. Among the hypotheses explored to explain Vietnam's high rate of abortion are the borrowing of family planning strategies from other poor socialist states where abortion is common; current antinatal population policies that interact with a lack of contraceptive alternatives; and a rise in pregnancies among young and unmarried women in the wake of recent free-market reforms. Because family-size preferences are still declining, abortion rates may continue to increase unless the incidence of unwanted pregnancy can be reduced, a goal that Vietnamese population specialists are seeking to achieve. PMID:7716799

  7. Is there really a W →τ ν puzzle?

    NASA Astrophysics Data System (ADS)

    Bhattacharya, Bhubanjyoti; London, David; Datta, Alakabha

    2016-05-01

    According to the Particle Data Group, the measurements of B (W+→τ+ντ) and B (W+→ℓ+νℓ)(ℓ=e , μ ) disagree with one another at the 2.3 σ level. In this paper, we search for a new-physics (NP) explanation of this W →τ ν puzzle. We consider two NP scenarios: (i) the W mixes with a W ' boson that couples preferentially to the third generation, (ii) τ L ,R and ντ L mix with isospin-triplet leptons. Unfortunately, once other experimental constraints are taken into account, neither scenario can explain the above experimental result. Our conclusion is that the W →τ ν puzzle is almost certainly just a statistical fluctuation.

  8. Laser Spectroscopy of Muonic Hydrogen and the Puzzling Proton

    NASA Astrophysics Data System (ADS)

    Pohl, Randolf

    2016-09-01

    Laser spectroscopy of muonic hydrogen atoms, μp, has revealed a proton root-mean-square (rms) charge radius rE that is an order of magnitude more accurate than the CODATA world average from elastic electron-proton scattering and precision spectroscopy of regular (electronic) hydrogen. Interestingly, though, the value of rE from μp is 4%, or 7 combined standard deviations smaller than the CODATA value of rE. This discrepancy has been coined "proton radius puzzle". We summarize the experiment and give a brief overview of the theory in muonic hydrogen. Finally we discuss some possible scenarios for the resolution of the "proton radius puzzle".

  9. Validation of Italian rebus puzzles and compound remote associate problems.

    PubMed

    Salvi, Carola; Costantini, Giulio; Bricolo, Emanuela; Perugini, Marco; Beeman, Mark

    2016-06-01

    Rebus puzzles and compound remote associate problems have been successfully used to study problem solving. These problems are physically compact, often can be solved within short time limits, and have unambiguous solutions, and English versions have been normed for solving rates and levels of difficulty. Many studies on problem solving with sudden insight have taken advantage of these features in paradigms that require many quick solutions (e.g., solution priming, visual hemifield presentations, electroencephalography, fMRI, and eyetracking). In order to promote this vein of research in Italy, as well, we created and tested Italian versions of both of these tests. The data collected across three studies yielded a pool of 88 rebus puzzles and 122 compound remote associate problems within a moderate range of difficulty. This article provides both sets of problems with their normative data, for use in future research. PMID:26148823

  10. On the explanation of Peele`s Pertinent Puzzle

    SciTech Connect

    Gai, E.V.

    1994-12-31

    Investigation of Peele`s Pertinent Puzzle (PPP) by analytical and numerical simulation shows that if covariations of experimental data are determined within frames of rigorous maximum likelihood method (MLM), then least-squares method (LSM) gives for PPP correct but unusually looking results. It is shown also that some restrictions and corrections outside rigorous MLM frame bring to incorrect results instead of improved ones.

  11. Radial flow afterburner for event generators and the baryon puzzle

    NASA Astrophysics Data System (ADS)

    Cuautle, E.; Paic, G.

    2008-07-01

    A simple afterburner to add radial flow to the randomized transverse momentum obtained from event generators, PYTHIA and HIJING, has been implemented to calculate the p/π ratios and compare them with available data. A coherent trend of qualitative agreement has been obtained in pp and Au+Au collisions for various centralities. These results indicate that the radial flow does play an important role in the so-called baryon puzzle anomaly.

  12. Puzzles about 1/8 magic doping in cuprate

    NASA Astrophysics Data System (ADS)

    Feng, D. L.; Shen, Z.-X.; Zhou, X. J.; Shen, K. M.; Lu, D. H.; Marel, D. V. D.

    2006-01-01

    We discuss the puzzles surrounding the interpretation of the 1/8 anomaly in cuprates, highlighting the tension between the real and reciprocal space ways to look at the problem. This issue is relevant to the current discussion on the nature of charge ordering in the form of ‘stripe’ and ‘checker-board’ as derived from neutron and STM experiments. A resolution of this tension is important to fully understand the electronic structure.

  13. Lorentz violation in the gravity sector: The t puzzle

    NASA Astrophysics Data System (ADS)

    Bonder, Yuri

    2015-06-01

    Lorentz violation is a candidate quantum-gravity signal, and the Standard-Model Extension (SME) is a widely used parametrization of such a violation. In the gravitational SME sector, there is an elusive coefficient for which no effects have been found. This is known as the t puzzle and, to date, it has no compelling explanation. This paper analyzes whether there is a fundamental explanation for the t puzzle. To tackle this question, several approaches are followed. Mainly, redefinitions of the dynamical fields are studied, showing that other SME coefficients can be moved to nongravitational sectors. It is also found that the gravity SME sector can be consistently treated à la Palatini, and that, in the presence of spacetime boundaries, it is possible to correct its action to get the desired equations of motion. Moreover, through a reformulation as a Lanczos-type tensor, some problematic features of the t term, which should arise at the phenomenological level, are revealed. The most important conclusion of the paper is that there is no evidence of a fundamental explanation for the t puzzle, suggesting that it may be linked to the approximations taken at the phenomenological level.

  14. Serotonin, Amygdala and Fear: Assembling the Puzzle

    PubMed Central

    Bocchio, Marco; McHugh, Stephen B.; Bannerman, David M.; Sharp, Trevor; Capogna, Marco

    2016-01-01

    The fear circuitry orchestrates defense mechanisms in response to environmental threats. This circuitry is evolutionarily crucial for survival, but its dysregulation is thought to play a major role in the pathophysiology of psychiatric conditions in humans. The amygdala is a key player in the processing of fear. This brain area is prominently modulated by the neurotransmitter serotonin (5-hydroxytryptamine, 5-HT). The 5-HT input to the amygdala has drawn particular interest because genetic and pharmacological alterations of the 5-HT transporter (5-HTT) affect amygdala activation in response to emotional stimuli. Nonetheless, the impact of 5-HT on fear processing remains poorly understood.The aim of this review is to elucidate the physiological role of 5-HT in fear learning via its action on the neuronal circuits of the amygdala. Since 5-HT release increases in the basolateral amygdala (BLA) during both fear memory acquisition and expression, we examine whether and how 5-HT neurons encode aversive stimuli and aversive cues. Next, we describe pharmacological and genetic alterations of 5-HT neurotransmission that, in both rodents and humans, lead to altered fear learning. To explore the mechanisms through which 5-HT could modulate conditioned fear, we focus on the rodent BLA. We propose that a circuit-based approach taking into account the localization of specific 5-HT receptors on neurochemically-defined neurons in the BLA may be essential to decipher the role of 5-HT in emotional behavior. In keeping with a 5-HT control of fear learning, we review electrophysiological data suggesting that 5-HT regulates synaptic plasticity, spike synchrony and theta oscillations in the BLA via actions on different subcellular compartments of principal neurons and distinct GABAergic interneuron populations. Finally, we discuss how recently developed optogenetic tools combined with electrophysiological recordings and behavior could progress the knowledge of the mechanisms underlying 5

  15. Nursing education: current themes, puzzles and paradoxes.

    PubMed

    Tanner, Christine A

    2007-01-01

    have been tremendously changed, with an emphasis on case-based instruction, integrating distance delivery technologies, and using simulation, drawing on best practices in the development of these approaches (Billings, et al., 2001; Issenberg, et al .2005; Jeffries, 2005). OCNE leaders obtained funding from Kaiser Permanente Northwest to begin the long, collaborative, consensus building process to transform clinical education. Evaluation has and will continue to be an integral part of this work, with an eye to adding to our collective knowledge of best practices in nursing education. We see evidence of similar efforts, mostly state or regional, in order to build on prior alliances, acknowledge geographic particularities, and respond to local needs in many other parts of the country, from Hawaii to New Jersey, Texas to Montana. The nursing shortage has been a primary catalyst. It has captured the interest of potential funders, individual donors, foundations to the Federal government. The keys are collaboration and a collective voice for nursing, a willingness to work through long-standing and divisive issues, and most importantly, a moral commitment to the populations we serve. PMID:17900063

  16. Effects of Imperfections on the Buckling Response of Compression-Loaded Composite Shells

    NASA Technical Reports Server (NTRS)

    Hilburger, Mark W.; Starnes, James H., Jr.

    2002-01-01

    The results of an experimental and analytical study of the effects of initial imperfections on the buckling and postbuckling response of three unstiffened thin-walled compression-loaded graphite-epoxy cylindrical shells with different orthotropic and quasi-isotropic shell-wall laminates are presented. The results identify the effects of traditional and non-traditional initial imperfections on the non-linear response and buckling loads of the shells. The traditional imperfections include the geometric shell-wall mid-surface imperfect ions that are commonly discussed in the literature on thin shell buckling. The non-traditional imperfections include shell-wall thickness variations local shell-wall ply-gaps associated with the fabrication process, sheltered geometric imperfections, non-uniform applied end loads, and variations in the boundary conditions including the effects of elastic boundary conditions. A high-fidelity non-linear shell analysis procedure that accurately accounts for the effects of these traditional and non-traditional imperfections on the nonlinear response, and buckling loads of the shells is described. The analysis procedure includes a non-linear static analysis that predicts stable response characteristics of the shells and a non-linear transient analysis that predicts unstable response characteristics.

  17. Robust Beamforming for Security in MIMO Wiretap Channels With Imperfect CSI

    NASA Astrophysics Data System (ADS)

    Mukherjee, Amitav; Swindlehurst, A. Lee

    2011-01-01

    In this paper, we investigate methods for reducing the likelihood that a message transmitted between two multiantenna nodes is intercepted by an undetected eavesdropper. In particular, we focus on the judicious transmission of artificial interference to mask the desired signal at the time it is broadcast. Unlike previous work that assumes some prior knowledge of the eavesdropper's channel and focuses on maximizing secrecy capacity, we consider the case where no information regarding the eavesdropper is available, and we use signal-to-interference-plus-noise-ratio (SINR) as our performance metric. Specifically, we focus on the problem of maximizing the amount of power available to broadcast a jamming signal intended to hide the desired signal from a potential eavesdropper, while maintaining a prespecified SINR at the desired receiver. The jamming signal is designed to be orthogonal to the information signal when it reaches the desired receiver, assuming both the receiver and the eavesdropper employ optimal beamformers and possess exact channel state information (CSI). In practice, the assumption of perfect CSI at the transmitter is often difficult to justify. Therefore, we also study the resulting performance degradation due to the presence of imperfect CSI, and we present robust beamforming schemes that recover a large fraction of the performance in the perfect CSI case. Numerical simulations verify our analytical performance predictions, and illustrate the benefit of the robust beamforming schemes.

  18. Imperfect supercritical bifurcation in a three-dimensional turbulent wake

    NASA Astrophysics Data System (ADS)

    Cadot, Olivier; Evrard, Antoine; Pastur, Luc

    2015-06-01

    The turbulent wake of a square-back body exhibits a strong bimodal behavior. The wake randomly undergoes symmetry-breaking reversals between two mirror asymmetric steady modes [reflectional symmetry-breaking (RSB) modes]. The characteristic time for reversals is about 2 or 3 orders of magnitude larger than the natural time for vortex shedding. Studying the effects of the proximity of a ground wall together with the Reynolds number, it is shown that the bimodal behavior is the result of an imperfect pitchfork bifurcation. The RSB modes correspond to the two stable bifurcated branches resulting from an instability of the stable symmetric wake. An attempt to stabilize the unstable symmetric wake is investigated using a passive control technique. Although the controlled wake still exhibits strong fluctuations, the bimodal behavior is suppressed and the drag reduced. This promising experiment indicates the possible existence of an unstable solution branch corresponding to a reflectional symmetry preserved (RSP) mode. This work is encouraging to develop a control strategy based on a stabilization of this RSP mode to reduce mean drag and lateral force fluctuations.

  19. Modeling species occurrence dynamics with multiple states and imperfect detection

    USGS Publications Warehouse

    MacKenzie, D.I.; Nichols, J.D.; Seamans, M.E.; Gutierrez, R.J.

    2009-01-01

    Recent extensions of occupancy modeling have focused not only on the distribution of species over space, but also on additional state variables (e.g., reproducing or not, with or without disease organisms, relative abundance categories) that provide extra information about occupied sites. These biologist-driven extensions are characterized by ambiguity in both species presence and correct state classification, caused by imperfect detection. We first show the relationships between independently published approaches to the modeling of multistate occupancy. We then extend the pattern-based modeling to the case of sampling over multiple seasons or years in order to estimate state transition probabilities associated with system dynamics. The methodology and its potential for addressing relevant ecological questions are demonstrated using both maximum likelihood (occupancy and successful reproduction dynamics of California Spotted Owl) and Markov chain Monte Carlo estimation approaches (changes in relative abundance of green frogs in Maryland). Just as multistate capture-recapture modeling has revolutionized the study of individual marked animals, we believe that multistate occupancy modeling will dramatically increase our ability to address interesting questions about ecological processes underlying population-level dynamics. ?? 2009 by the Ecological Society of America.

  20. Sensitivity of actively damped structures to imperfections and modeling errors

    NASA Technical Reports Server (NTRS)

    Haftka, Raphael T.; Kapania, Rakesh K.

    1989-01-01

    The sensitivity of actively damped response of structures with respect to errors in the structural modeling is studied. Two ways of representing errors are considered. The first approach assumes errors in the form of spatial variations (or imperfections) in the assumed mass and stiffness properties of the structures. The second approach assumes errors due to such factors as unknown joint stiffnesses, discretization errors, and nonlinearities. These errors are represented here as discrepancies between experimental and analytical mode shapes and frequencies. The actively damped system considered here is a direct-rate feedback regulator based on a number of colocated velocity sensors and force actuators. The response of the controlled structure is characterized by the eigenvalues of the closed-loop system. The effects of the modeling errors are thus presented as the sensitivity of the eigenvalues of the closed-loop system. Results are presented for two examples: (1) a three-span simply supported beam controlled by three sensors and actuators, and (2) a laboratory structure consisting of a cruciform beam supported by cables.

  1. CD271 is an imperfect marker for melanoma initiating cells

    PubMed Central

    Cheli, Yann; Bonnazi, Vanessa F.; Jacquel, Arnaud; Allegra, Maryline; Donatis, Gian Marco De; Bahadoran, Philippe; Bertolotto, Corine; Ballotti, Robert

    2014-01-01

    Understanding the molecular and cellular processes underlying melanoma plasticity and heterogeneity is of paramount importance to improve the efficiency of current treatment and to overcome resistance to chemotherapy drugs. The notion of plasticity and heterogeneity implies the existence of melanoma cell populations with different phenotypic and tumorigenic properties. Using melanoma cell lines and melanoma cells freshly isolated from patient biopsies, we investigated the relationship between ABCB5+, CD271+ and low-MITF, expressing populations that were reported to display melanoma initiating cell properties. Here, we showed that ABCB5+ and CD271+ populations poorly overlap. However, we found that the CD271+ population is enriched in low-MITF cells and expresses a higher level of stemness genes, such as OCT4, NANOG and NES. These features could explain the increased tumorigenicity of the CD271+ cells. The rapid conversion of CD271+ to CD271− cells in vitro demonstrates the plasticity ability of melanoma cells. Finally, we observed that the transient slow-growing population contains only CD271+ cells that are highly tumorigenic. However, the fast growing/CD271+ population exhibits a poor tumorigenic ability. Taking together, our data show that CD271 is an imperfect marker for melanoma initiating cells, but may be useful to identify melanoma cells with an increased stemness and tumorigenic potential. PMID:25105565

  2. Many-body localization in imperfectly isolated quantum systems.

    PubMed

    Johri, Sonika; Nandkishore, Rahul; Bhatt, R N

    2015-03-20

    We use numerical exact diagonalization to analyze which aspects of the many-body localization phenomenon survive in an imperfectly isolated setting, when the system of interest is weakly coupled to a thermalizing environment. We show that widely used diagnostics (such as many-body level statistics and expectation values in exact eigenstates) cease to show signatures of many-body localization above a critical coupling that is exponentially small in the size of the environment. However, we also identify alternative diagnostics for many-body localization, in the spectral functions of local operators. Diagnostics include a discrete spectrum and a hierarchy of energy gaps, including a universal gap at zero frequency. These alternative diagnostics are shown to be robust, and continue to show signatures of many-body localization as long as the coupling to the bath is weaker than the characteristic energy scales in the system. We also examine how these signatures disappear when the coupling to the environment becomes larger than the characteristic energy scales of the system. PMID:25839306

  3. Long-distance quantum key distribution with imperfect devices

    NASA Astrophysics Data System (ADS)

    Lo Piparo, Nicoló; Razavi, Mohsen

    2013-07-01

    Quantum key distribution over probabilistic quantum repeaters is addressed. We compare, under practical assumptions, two such schemes in terms of their secret key generation rates per quantum memory. The two schemes under investigation are the one proposed by Duan [Nature (London)0028-083610.1038/35106500 414, 413 (2001)] and that of Sangouard [Phys. Rev. A1050-294710.1103/PhysRevA.76.050301 76, 050301 (2007)]. We consider various sources of imperfection in both protocols, such as nonzero double-photon probabilities at the sources, dark counts in detectors, and inefficiencies in the channel, photodetectors, and memories. We also consider memory decay and dephasing processes in our analysis. For the latter system, we determine the maximum value of the double-photon probability beyond which secret key distillation is not possible. We also find crossover distances for one nesting level to its subsequent one. We finally compare the two protocols in terms of their achievable secret key generation rates at their optimal settings. Our results specify regimes of operation where one system outperforms the other.

  4. Imperfect supercritical bifurcation in a three-dimensional turbulent wake.

    PubMed

    Cadot, Olivier; Evrard, Antoine; Pastur, Luc

    2015-06-01

    The turbulent wake of a square-back body exhibits a strong bimodal behavior. The wake randomly undergoes symmetry-breaking reversals between two mirror asymmetric steady modes [reflectional symmetry-breaking (RSB) modes]. The characteristic time for reversals is about 2 or 3 orders of magnitude larger than the natural time for vortex shedding. Studying the effects of the proximity of a ground wall together with the Reynolds number, it is shown that the bimodal behavior is the result of an imperfect pitchfork bifurcation. The RSB modes correspond to the two stable bifurcated branches resulting from an instability of the stable symmetric wake. An attempt to stabilize the unstable symmetric wake is investigated using a passive control technique. Although the controlled wake still exhibits strong fluctuations, the bimodal behavior is suppressed and the drag reduced. This promising experiment indicates the possible existence of an unstable solution branch corresponding to a reflectional symmetry preserved (RSP) mode. This work is encouraging to develop a control strategy based on a stabilization of this RSP mode to reduce mean drag and lateral force fluctuations. PMID:26172790

  5. Effect of Surface Imperfections and Excrescences on the Crossflow Instability

    NASA Astrophysics Data System (ADS)

    Tufts, Matthew; Duncan, Glen, Jr.; Crawford, Brian; Reed, Helen; Saric, William

    2012-11-01

    Presented is analysis of the planned SWIFTER experiment to be flown on Texas A&M University's O-2A aircraft. Simultaneous control of the crossflow and streamwise boundary-layer instabilities is a challenge for laminar flow control on swept wings. Solving this problem is an active area of research, with a specific need to quantify the effect of surface imperfections and outer mold line excrescences on crossflow instabilities. The SWIFTER test article is a modification of a prior-tested flight model, with the additional capability of creating controlled excrescences in flight. Using a finite-element Navier-Stokes solution and a spectrally accurate boundary-layer solver, coupled with linear and nonlinear stability analyses, we show that the flow field over the test article is well suited to this study. Results are compared with flight data. The work is supported by the Air Force Research Laboratory through General Dynamics Information Technology, Inc. under sub Agreement No USAF-3446-11-50-SC-01 and the Texas A&M Supercomputing Facility.

  6. Information Loss Associated with Imperfect Observation and Mismatched Decoding

    PubMed Central

    Oizumi, Masafumi; Okada, Masato; Amari, Shun-Ichi

    2011-01-01

    We consider two types of causes leading to information loss when neural activities are passed and processed in the brain. One is responses of upstream neurons to stimuli being imperfectly observed by downstream neurons. The other is upstream neurons non-optimally decoding stimuli information contained in the activities of the downstream neurons. To investigate the importance of neural correlation in information processing in the brain, we specifically consider two situations. One is when neural responses are not simultaneously observed, i.e., neural correlation data is lost. This situation means that stimuli information is decoded without any specific assumption about neural correlations. The other is when stimuli information is decoded by a wrong statistical model where neural responses are assumed to be independent even when they are not. We provide the information geometric interpretation of these two types of information loss and clarify their relationship. We then concretely evaluate these types of information loss in some simple examples. Finally, we discuss use of these evaluations of information loss to elucidate the importance of correlation in neural information processing. PMID:21629857

  7. Information loss associated with imperfect observation and mismatched decoding.

    PubMed

    Oizumi, Masafumi; Okada, Masato; Amari, Shun-Ichi

    2011-01-01

    We consider two types of causes leading to information loss when neural activities are passed and processed in the brain. One is responses of upstream neurons to stimuli being imperfectly observed by downstream neurons. The other is upstream neurons non-optimally decoding stimuli information contained in the activities of the downstream neurons. To investigate the importance of neural correlation in information processing in the brain, we specifically consider two situations. One is when neural responses are not simultaneously observed, i.e., neural correlation data is lost. This situation means that stimuli information is decoded without any specific assumption about neural correlations. The other is when stimuli information is decoded by a wrong statistical model where neural responses are assumed to be independent even when they are not. We provide the information geometric interpretation of these two types of information loss and clarify their relationship. We then concretely evaluate these types of information loss in some simple examples. Finally, we discuss use of these evaluations of information loss to elucidate the importance of correlation in neural information processing. PMID:21629857

  8. Strategies and correlates of jigsaw puzzle and visuospatial performance by persons with Prader-Willi syndrome.

    PubMed

    Verdine, Brian N; Troseth, Georgene L; Hodapp, Robert M; Dykens, Elisabeth M

    2008-09-01

    Some individuals with Prader-Willi syndrome exhibit strengths in solving jigsaw puzzles. We compared visuospatial ability and jigsaw puzzle performance and strategies of 26 persons with Prader-Willi syndrome and 26 MA-matched typically developing controls. Individuals with Prader-Willi syndrome relied on piece shape. Those in the control group used a different, picture-focused strategy. Individuals with Prader-Willi syndrome performed better than did the control group on an achromatic interlocking puzzle, whereas scores on puzzles with pictures (interlocking or noninterlocking) did not differ. Visuospatial scores related to performance on all puzzles in the control group and on the noninterlocking puzzle in the Prader-Willi syndrome group. The most proficient jigsaw puzzlers with Prader-Willi syndrome tended to be older and have shape-based strategies. PMID:18702555

  9. Buckling and postbuckling behaviour of imperfect laminated shallow spherical shells under external pressure

    NASA Astrophysics Data System (ADS)

    Muc, A.

    The paper deals with the static buckling and postbuckling behavior of clamped elastic imperfect laminated shallow spherical shells subjected to uniform external pressure. Three types of initial geometrical imperfections are analyzed: two local described by a convex or a concave curve, and one global in the form of the Legendre polynomial. Applying the Rayleigh-Ritz procedure to Marguerre's equations combined with the precise prebuckling numerical analysis, reasonably accurate solutions are obtained for upper and lower buckling pressures. The effects of fiber orientations on pre- and postbuckling behavior, imperfection sensitivity, buckling loads, and modes are considered. The results for composite shells are compared with those calculated for quasi-isotropic ones.

  10. Analysis and testing of axial compression in imperfect slender truss struts

    NASA Technical Reports Server (NTRS)

    Lake, Mark S.; Georgiadis, Nicholas

    1990-01-01

    The axial compression of imperfect slender struts for large space structures is addressed. The load-shortening behavior of struts with initially imperfect shapes and eccentric compressive end loading is analyzed using linear beam-column theory and results are compared with geometrically nonlinear solutions to determine the applicability of linear analysis. A set of developmental aluminum clad graphite/epoxy struts sized for application to the Space Station Freedom truss are measured to determine their initial imperfection magnitude, load eccentricity, and cross sectional area and moment of inertia. Load-shortening curves are determined from axial compression tests of these specimens and are correlated with theoretical curves generated using linear analysis.

  11. The role of genetics in estrogen responses: a critical piece of an intricate puzzle

    PubMed Central

    Wall, Emma H.; Hewitt, Sylvia C.; Case, Laure K.; Lin, Chin-Yo; Korach, Kenneth S.; Teuscher, Cory

    2014-01-01

    The estrogens are female sex hormones that are involved in a variety of physiological processes, including reproductive development and function, wound healing, and bone growth. They are mainly known for their roles in reproductive tissues—specifically, 17β-estradiol (E2), the primary estrogen, which is secreted by the ovaries and induces cellular proliferation and growth of the uterus and mammary glands. In addition to the role of estrogens in promoting tissue growth and development during normal physiological states, they have a well-established role in determining susceptibility to disease, particularly cancer, in reproductive tissues. The responsiveness of various tissues to estrogen is genetically controlled, with marked quantitative variation observed across multiple species, including humans. This variation presents both researchers and clinicians with a veritable physiological puzzle, the pieces of which—many of them unknown—are complex and difficult to fit together. Although genetics is known to play a major role in determining sensitivity to estrogens, there are other factors, including parent of origin and the maternal environment, that are intimately linked to heritable phenotypes but do not represent genotype, per se. The objectives of this review article were to summarize the current knowledge of the role of genotype, and uterine and neonatal environments, in phenotypic variation in the response to estrogens; to discuss recent findings and the potential mechanisms involved; and to highlight exciting research opportunities for the future.—Wall, E. H., Hewitt, S. C., Case, L. K, Lin, C.-Y., Korach, K. S., Teuscher, C. The role of genetics in estrogen responses: a critical piece of an intricate puzzle. PMID:25212221

  12. High-energy cosmic neutrino puzzle: a review.

    PubMed

    Ahlers, Markus; Halzen, Francis

    2015-12-01

    We appraise the status of high-energy neutrino astronomy and summarize the observations that define the 'IceCube puzzle.' The observations are closing in on the source candidates that may contribute to the observation. We highlight the potential of multi-messenger analysis to assist in the identification of the sources. We also give a brief overview of future search strategies that include the realistic possibility of constructing a next-generation detector larger by one order of magnitude in volume. PMID:26510451

  13. ysteries, Puzzles, and Paradoxes in Quantum Mechanics. Proceedings

    SciTech Connect

    Rodolfo, B.

    1999-02-01

    These proceedings represent papers presented at the Mysteries, Puzzles, and Paradoxes in Quantum Mechanics Workshop held in Italy, in August 1998. The Workshop was devoted to recent experimental and theoretical advances such as new interference, effects, the quantum eraser, non{minus}disturbing and Schroedinger{minus}cat{minus}like states, experiments, EPR correlations, teleportation, superluminal effects, quantum information and computing, locality and causality, decoherence and measurement theory. Tachyonic information transfer was also discussed. There were 45 papers presented at the conference,out of which 2 have been abstracted for the Energy,Science and Technology database.(AIP)

  14. Mixed heavy quark hybrid mesons, decay puzzles, and RHIC

    SciTech Connect

    Kisslinger, Leonard S.

    2009-06-01

    We estimate the energy of the lowest charmonium and upsilon states with hybrid admixtures using the method of QCD sum rules. Our results show that the {psi}{sup '}(2S) and {upsilon}(3S) states both have about a 50% admixture of hybrid and meson components. From this we find explanations of both the famous {rho}-{pi} puzzle for charmonium and the unusual pattern of {sigma} decays that have been found in {upsilon} decays. Moreover, this picture can be used for predictions of heavy quark production with the octet model for RHIC.

  15. Tetsuo Nozoe's Autograph Books: poems, puzzles and playfulness.

    PubMed

    Seeman, Jeffrey I

    2015-02-01

    The Nozoe Autograph Books contain entries from, literally, around the world of organic chemistry. Many of the inscriptions showed the poetic or even musical side of their signees. This Essay presents a diverse selection of the poetic entries of the autograph books, starting with a musical puzzle. This Essay and the interactive website that accompanies the Nozoe Autograph Book project are available free-access for at least a three-year period at http://www.tcr.wiley-vch.de/nozoe. PMID:25690991

  16. Buckling and Failure of Compression-Loaded Composite Cylindrical Shells With Geometric and Material Imperfections

    NASA Technical Reports Server (NTRS)

    Hilburger, Mark W.; Starnes, James H., Jr.

    2004-01-01

    The results of an experimental and numerical study of the effects of initial imperfections on the buckling response and failure of unstiffened thin-walled compression-loaded graphite-epoxy cylindrical shells are presented. The shells considered in the study have six different orthotropic or quasi-isotropic shell-wall laminates and two different shell-radius-to-thickness ratios. The numerical results include the effects of geometric shell-wall mid-surface imperfections, shell-wall thickness variations, local shell-wall ply-gaps associated with the fabrication process, shell-end geometric imperfections, nonuniform end loads, and the effects of elastic boundary conditions. Selected cylinder parameter uncertainties were also considered. Results that illustrate the effects of imperfections and uncertainties on the nonlinear response characteristics, buckling loads and failure the shells are presented. In addition, a common failure analysis is used to predict material failures in the shells.

  17. Understanding Your Vision: The “Imperfect Eye” | NIH MedlinePlus the Magazine

    MedlinePlus

    ... of this page please turn Javascript on. Feature: Vision Understanding Your Vision: The “Imperfect Eye” Past Issues / Winter 2012 Table ... are different and so are the types of vision that we have. Understanding how some of us ...

  18. The Influence of Hollow Imperfections of Adhesive on Performances of Interface of RC Beams Strengthened with HFRP

    SciTech Connect

    Guo Yongchang; Li Lijuan; Deng Jun; Zhong Genquan

    2010-05-21

    The mechanical characteristics of the interface with hollow imperfections for reinforced concrete (RC) beams strengthened with Carbon-Glass fiber sheet is discussed, which is a new hybrid strengthening method. By establishing the constitutive equations of different materials, three interfacial models including imperfection dimension, imperfection location and imperfection amount are simulated using nonlinear finite element method. The shear stress and normal stress of glue layer, the first principal stress of concrete at the end of the interface and the stress distributions of different strengthening modes are analyzed. The results show that the shear stress of glue layer is sensitive for imperfection dimension and significantly increases with the imperfection dimension. However, the first principal stress of the concrete at the end of the interface marginally decreases with the imperfection dimension.

  19. The Influence of Hollow Imperfections of Adhesive on Performances of Interface of RC Beams Strengthened with HFRP

    NASA Astrophysics Data System (ADS)

    Yongchang, Guo; Lijuan, Li; Jun, Deng; Genquan, Zhong

    2010-05-01

    The mechanical characteristics of the interface with hollow imperfections for reinforced concrete (RC) beams strengthened with Carbon-Glass fiber sheet is discussed, which is a new hybrid strengthening method. By establishing the constitutive equations of different materials, three interfacial models including imperfection dimension, imperfection location and imperfection amount are simulated using nonlinear finite element method. The shear stress and normal stress of glue layer, the first principal stress of concrete at the end of the interface and the stress distributions of different strengthening modes are analyzed. The results show that the shear stress of glue layer is sensitive for imperfection dimension and significantly increases with the imperfection dimension. However, the first principal stress of the concrete at the end of the interface marginally decreases with the imperfection dimension.

  20. EPIDEMIOLOGICAL CONSEQUENCES OF IMPERFECT VACCINES FOR IMMUNIZING INFECTIONS

    PubMed Central

    MAGPANTAY, F.M.G.; RIOLO, M.A.; DE CELLÈS, M. DOMENECH; KING, A.A.; ROHANI, P.

    2015-01-01

    The control of some childhood diseases has proven to be difficult even in countries that maintain high vaccination coverage. This may be due to the use of imperfect vaccines and there has been much discussion on the different modes by which vaccines might fail. To understand the epidemiological implications of some of these different modes, we performed a systematic analysis of a model based on the standard SIR equations with a vaccinated component that permits vaccine failure in degree (“leakiness”), take (“all-or-nothingness”) and duration (waning of vaccine-derived immunity). The model was first considered as a system of ordinary differential equations, then extended to a system of partial differential equations to accommodate age structure. We derived analytic expressions for the steady states of the system and the final age distributions in the case of homogenous contact rates. The stability of these equilibria are determined by a threshold parameter Rp, a function of the vaccine failure parameters and the coverage p. The value of p for which Rp = 1 yields the critical vaccination ratio, a measure of herd immunity. Using this concept we can compare vaccines that confer the same level of herd immunity to the population but may fail at the individual level in different ways. For any fixed Rp > 1, the leaky model results in the highest prevalence of infection, while the all-or-nothing and waning models have the same steady state prevalence. The actual composition of a vaccine cannot be determined on the basis of steady state levels alone, however the distinctions can be made by looking at transient dynamics (such as after the onset of vaccination), the mean age of infection, the age distributions at steady state of the infected class, and the effect of age-specific contact rates. PMID:25878365

  1. Quantum state tomography with noninstantaneous measurements, imperfections, and decoherence

    NASA Astrophysics Data System (ADS)

    Six, P.; Campagne-Ibarcq, Ph.; Dotsenko, I.; Sarlette, A.; Huard, B.; Rouchon, P.

    2016-01-01

    Tomography of a quantum state is usually based on a positive-operator-valued measure (POVM) and on their experimental statistics. Among the available reconstructions, the maximum-likelihood (MaxLike) technique is an efficient one. We propose an extension of this technique when the measurement process cannot be simply described by an instantaneous POVM. Instead, the tomography relies on a set of quantum trajectories and their measurement records. This model includes the fact that, in practice, each measurement could be corrupted by imperfections and decoherence, and could also be associated with the record of continuous-time signals over a finite amount of time. The goal is then to retrieve the quantum state that was present at the start of this measurement process. The proposed extension relies on an explicit expression of the likelihood function via the effective matrices appearing in quantum smoothing and solutions of the adjoint quantum filter. It allows us to retrieve the initial quantum state as in standard MaxLike tomography, but where the traditional POVM operators are replaced by more general ones that depend on the measurement record of each trajectory. It also provides, aside from the MaxLike estimate of the quantum state, confidence intervals for any observable. Such confidence intervals are derived, as the MaxLike estimate, from an asymptotic expansion of multidimensional Laplace integrals appearing in Bayesian mean estimation. A validation is performed on two sets of experimental data: photon(s) trapped in a microwave cavity subject to quantum nondemolition measurements relying on Rydberg atoms, and heterodyne fluorescence measurements of a superconducting qubit.

  2. Monitoring programs need to take into account imperfect species detectability

    USGS Publications Warehouse

    Kery, M.; Schmid, H.

    2004-01-01

    Biodiversiry monitoring is important to identify biological units in need of conservation and to check the effectiveness of conservation actions. Programs generally monitor species richness and its changes (trend). Usually, no correction is made for imperfect species detectability. Instead, it is assumed that each species present has the same probability of being recorded and that there is no difference in this detectability across space and time, e.g. among observers and habitats. Consequently, species richness is determined by enumeration as the sum of species recorded. In Switzerland, the federal government has recently launched a comprehensive program that aims at detecting changes in biodiversity at all levels of biological integration. Birds are an important part of that program. Since 1999, 23 visits per breeding season are made to each of >250 1 km2 squares to map the territories of all detected breeding bird species. Here, we analyse data from three squares to illustrate the use of capture-recapture models in monitoring to obtain detectability-corrected estimates of species richness and trend. Species detectability averaged only 85%. Hence an estimated 15% of species present remained overlooked even after three visits. Within a square, changes in detectability for different years were of the same magnitude when surveys were conducted by the same observer as when they were by different observers. Estimates of trend were usually biased and community turnover was overestimated when based on enumeration. Here we use bird data as an illustration of methods. However, species detectability for any taxon is unlikely ever to be perfect or even constant across categories to be compared. Therefore, monitoring programs should correct for species detectability.

  3. Effect of joint imperfections on static control of adaptive structures as space cranes

    NASA Technical Reports Server (NTRS)

    Ramesh, A. V.; Utku, Senol; Wada, B. K.; Chen, G. S.

    1990-01-01

    Effect of imperfections in the joints of an adaptive structure on its slow (no inertia forces) motion along a prescribed trajectory as a space crane is studied. Two mathematical models to predict the effect of joint imperfections are proposed. The two models are used to obtain estimates of the deviations of the node of the space crane to which the end-effector is attached, from its prescribed trajectory. An application of the models to a two-section space crane is given.

  4. Effect of imperfections on static control of adaptive structures as a space crane

    NASA Technical Reports Server (NTRS)

    Ramesh, A. V.; Utku, S.; Wada, B. K.; Chen, G. S.

    1989-01-01

    Effect of imperfections in the joints of an adaptive structure on its slow (no inertia forces) motion along a prescribed trajectory as a space crane is studied. Two mathematical models to predict the effect of joint imperfections are proposed. The two models are used to obtain estimates of the deviations of the node of the space crane to which the end-effector is attached, from its prescribed trajectory. An application of the models to a two-section space crane is given.

  5. Three-dimensional piezoelasticity solution for piezolaminated angle-ply cylindrical shells featuring imperfect interfacial bonding

    NASA Astrophysics Data System (ADS)

    Kapuria, S.; Kumar, Amit

    2010-04-01

    The work presents an analytical three-dimensional solution for simply supported angle-ply piezoelectric (hybrid) laminated cylindrical shells in cylindrical bending with interlaminar bonding imperfections, in an electro-thermomechanical loading environment. The jumps in displacements, electric potential and temperature at the imperfect interfaces are modeled using linear spring-layer model. The solution includes the case when, besides at inner and outer surfaces, electric potentials are prescribed at layer interfaces also for effective actuation/sensing. The entities for each layer are expanded in Fourier series in circumferential coordinate to satisfy the boundary conditions at the simply supported ends. The resulting ordinary differential equations in thickness coordinate with variable coefficients are solved by the modified Frobenius method. Numerical results are presented for hybrid composite and sandwich shells with varying imperfection compliance. The effect of location of imperfect interface on the response is studied for cross-ply panels while the effect of ply angle on the sensitivity towards imperfection is studied for angle-ply panels. The effect of weak bonding at actuator/sensor interface on the actuation/sensing authority is investigated. The presented results would also help assessing 2D shell theories that incorporate interlaminar bonding imperfections.

  6. Ecological and Evolutionary Processes Drive the Origin and Maintenance of Imperfect Mimicry

    PubMed Central

    Wilson, Joseph S.; Jahner, Joshua P.; Williams, Kevin A.; Forister, Matthew L.

    2013-01-01

    Although the forces behind the evolution of imperfect mimicry remain poorly studied, recent hypotheses suggest that relaxed selection on small-bodied individuals leads to imperfect mimicry. While evolutionary history undoubtedly affects the development of imperfect mimicry, ecological community context has largely been ignored and may be an important driver of imperfect mimicry. Here we investigate how evolutionary and ecological contexts might influence mimetic fidelity in Müllerian and Batesian mimicry systems. In Batesian hoverfly systems we find that body size is not a strong predictor of mimetic fidelity. However, in Müllerian velvet ants we find a weak positive relationship between body size and mimetic fidelity when evolutionary context is controlled for and a much stronger relationship between community diversity and mimetic fidelity. These results suggest that reduced selection on small-bodied individuals may not be a major driver of the evolution of imperfect mimicry and that other factors, such as ecological community context, should be considered when studying the evolution of imperfect mimicry. PMID:23593490

  7. May heavy neutrinos solve underground and cosmic-ray puzzles?

    SciTech Connect

    Belotsky, K. M. Fargion, D. Khlopov, M. Yu. Konoplich, R. V.

    2008-01-15

    Primordial heavy neutrinos of the fourth generation might explain different astrophysical puzzles. The simplest fourth-neutrino scenario is consistent with known fourth-neutrino physics, cosmic ray antimatter, cosmic gamma fluxes, and positive signals in underground detectors for a very narrow neutrino mass window (46-47 GeV). However, accounting for the constraint of underground experiment CDMS prohibits solution of cosmic-ray puzzles in this scenario. We have analyzed extended heavy-neutrino models related to the clumpiness of neutrino density, new interactions in heavy-neutrino annihilation, neutrino asymmetry, and neutrino decay. We found that, in these models, the cosmic-ray imprint may fit the positive underground signals in DAMA/Nal experiment in the entire mass range 46-70 GeV allowed from uncertainties of electroweak parameters, while satisfaction of the CDMS constraint reduces the mass range to around 50 GeV, where all data can come to consent in the framework of the considered hypothesis.

  8. Yet another possible explanation of the solar-neutrino puzzle

    SciTech Connect

    Kolb, E.W.; Turner, M.S.; Walker, T.P.

    1986-04-01

    Mikheyev and Smirnov have shown that the interactions of neutrinos with matter can result in the conversion of electron neutrinos produced in the center of the sun to muon neutrinos. Bethe has exploited this and has pointed out that the solar-neutrino puzzle can be resolved if the mass difference squared of the two neutrinos is m/sub 2//sup 2/ - m /sub 1//sup 2/ approx. = 6 x 10/sup -5/ eV/sup 2/, and the mixing angle satisfies sin theta/sub v/ > 0.0065. We discuss a qualitatively different solution to the solar-neutrino puzzle which requires 1.0 x 10/sup -8/ < (m/sub 2//sup 2/ - m/sub 1//sup 2/) (sin/sup 2/ 2theta/sub v//cos 2theta/sub v/) < 6.1 x 10/sup -8/ eV/sup 2/. Our solutions result in a much smaller flux of neutrinos from the p - p process than predicted by standard solar models, while Bethe's solution results in a flux of neutrinos from the p - process that is about the same as standard solar models.

  9. Simultaneous explanation of the RK and R (D (*)) puzzles

    NASA Astrophysics Data System (ADS)

    Bhattacharya, Bhubanjyoti; Datta, Alakabha; London, David; Shivashankara, Shanmuka

    2015-03-01

    At present, there are several hints of lepton flavor non-universality. The LHCb Collaboration has measured RK ≡ B (B+ →K+μ+μ-) / B (B+ →K+e+e-), and the BaBar Collaboration has measured R (D (*)) ≡ B (B bar →D (*) +τ-νbarτ) / B (B bar →D (*) +ℓ-νbarℓ) (ℓ = e , μ). In all cases, the experimental results differ from the standard model predictions by 2- 3 σ. Recently, an explanation of the RK puzzle was proposed in which new physics (NP) generates a neutral-current operator involving only third-generation particles. Now, assuming the scale of NP is much larger than the weak scale, this NP operator must be made invariant under the full SU (3)C × SU (2)L × U(1)Y gauge group. In this Letter, we note that, when this is done, a new charged-current operator can appear, and this can explain the R (D (*)) puzzle. A more precise measurement of the double ratio R (D) / R (D*) can rule out this model.

  10. Tiny bubbles challenge giant turbines: Three Gorges puzzle.

    PubMed

    Li, Shengcai

    2015-10-01

    Since the birth of the first prototype of the modern reaction turbine, cavitation as conjectured by Euler in 1754 always presents as a challenge. Following his theory, the evolution of modern reaction (Francis and Kaplan) turbines has been completed by adding the final piece of the element 'draft-tube' that enables turbines to explore water energy at efficiencies of almost 100%. However, during the last two and a half centuries, with increasing unit capacity and specific speed, the problem of cavitation has been manifested and complicated by the draft-tube surges rather than being solved. Particularly, during the last 20 years, the fierce competition in the international market for extremely large turbines with compact design has encouraged the development of giant Francis turbines of 700-1000 MW. The first group (24 units) of such giant turbines of 700 MW each was installed in the Three Gorges project. Immediately after commission, a strange erosion phenomenon appeared on the guide vane of the machines that has puzzled professionals. From a multi-disciplinary analysis, this Three Gorges puzzle could reflect an unknown type of cavitation inception presumably triggered by turbulence production from the boundary-layer streak transitional process. It thus presents a fresh challenge not only to this old turbine industry, but also to the fundamental sciences. PMID:26442144

  11. The puzzling unsolved mysteries of liquid water: Some recent progress

    NASA Astrophysics Data System (ADS)

    Stanley, H. E.; Kumar, P.; Xu, L.; Yan, Z.; Mazza, M. G.; Buldyrev, S. V.; Chen, S.-H.; Mallamace, F.

    2007-12-01

    Water is perhaps the most ubiquitous, and the most essential, of any molecule on earth. Indeed, it defies the imagination of even the most creative science fiction writer to picture what life would be like without water. Despite decades of research, however, water's puzzling properties are not understood and 63 anomalies that distinguish water from other liquids remain unsolved. We introduce some of these unsolved mysteries, and demonstrate recent progress in solving them. We present evidence from experiments and computer simulations supporting the hypothesis that water displays a special transition point (which is not unlike the “tipping point” immortalized by Malcolm Gladwell). The general idea is that when the liquid is near this “tipping point,” it suddenly separates into two distinct liquid phases. This concept of a new critical point is finding application to other liquids as well as water, such as silicon and silica. We also discuss related puzzles, such as the mysterious behavior of water near a protein.

  12. Security issues of quantum cryptographic systems with imperfect detectors

    NASA Astrophysics Data System (ADS)

    Burenkov, Viacheslav

    The laws of quantum physics can be used to secure communications between two distant parties in a scheme called quantum key distribution (QKD), even against a technologically unlimited eavesdropper. While the theoretical security of QKD has been proved rigorously, current implementations of QKD are generally insecure. In particular, mathematical models of devices, such as detectors, do not accurately describe their real-life behaviour. Such seemingly insignificant discrepancies can compromise the security of the entire scheme, especially as novel detector technologies are being developed with little regard for potential vulnerabilities. In this thesis, we study how detector imperfections can impact the security of QKD and how to overcome such technological limitations. We first analyze the security of a high-speed QKD system with finite detector dead time tau. We show that the previously reported sifting approaches are not guaranteed to be secure in this regime. More specifically, Eve can induce a basis-dependent detection efficiency at the receiver's end. Modified key sifting schemes that are basis-independent, and thus secure in the presence of dead time and an active eavesdropper, are discussed and compared. It is shown that the maximum key generation rate is 1/(2tau) for passive basis selection, and 1/tau for active basis selection. The security analysis is also extended to the decoy state BB84 protocol. We then study a relatively new type of single-photon detector called the superconducting nanowire single-photon detector (SNSPD), and discover some unexpected behaviour. We report an afterpulsing effect present when the SNSPD is operated in the high bias current regime. In our standard set-up, the afterpulsing is most likely to occur at around 180 ns following a detection event, for both real counts and dark counts. We characterize the afterpulsing behaviour and speculate that it is not due to the SNSPD itself but rather the associated read-out circuit. We also

  13. Studying the proton 'radius' puzzle with μp elastic scattering

    SciTech Connect

    Gilman, R.

    2013-11-07

    The disagreement between the proton radius determined from muonic hydrogen and from electronic measurements is called the proton radius puzzle. The resolution of the puzzle remains unclear and appears to require new experimental results. An experiment to measure muon-proton elastic scattering is presented here.

  14. Strategies and Correlates of Jigsaw Puzzle and Visuospatial Performance by Persons with Prader-Willi Syndrome

    ERIC Educational Resources Information Center

    Verdine, Brian N.; Troseth, Georgene L.; Hodapp, Robert M.; Dykens, Elisabeth M.

    2008-01-01

    Some individuals with Prader-Willi syndrome exhibit strengths in solving jigsaw puzzles. We compared visuospatial ability and jigsaw puzzle performance and strategies of 26 persons with Prader-Willi syndrome and 26 MA-matched typically developing controls. Individuals with Prader-Willi syndrome relied on piece shape. Those in the control group…

  15. What Puzzles Teachers in Rio de janeiro, and What Keeps Them Going?

    ERIC Educational Resources Information Center

    Lyra, Isolina; Fish, Solange; Braga, Walewska Gomes

    2003-01-01

    Focuses on the key mechanism of "puzzling" in Exploratory Practice (EP), a form of practitioner research, and the critical issue of sustainability in the context of volunteer teacher development work in Rio de Janeiro, Brazil. Investigated puzzles (concerns) of language teachers and grouped them into six categories; motivation, anxiety, teaching,…

  16. A Teacher's Ready-to-Use Packet of General Business Subjects Crossword Puzzles.

    ERIC Educational Resources Information Center

    Yacyk, Peter

    Eleven crossword puzzles, designed to give the student practice with the correct spelling and usage of those words needed to indicate his mastery of the concepts and understandings taught in business courses, are contained, with answer keys, in a teacher's packet. Any puzzle can be reproduced by ditto or by transparency for classroom use. There is…

  17. The King and Prisoner Puzzle: A Way of Introducing the Components of Logical Structures

    ERIC Educational Resources Information Center

    Roh, Kyeong Hah; Lee, Yong Hah; Tanner, Austin

    2016-01-01

    The purpose of this paper is to provide issues related to student understanding of logical components that arise when solving word problems. We designed a logic problem called the King and Prisoner Puzzle--a linguistically simple, yet logically challenging problem. In this paper, we describe various student solutions to the puzzle and discuss the…

  18. An Alternative Evaluation: Online Puzzle as a Course-End Activity

    ERIC Educational Resources Information Center

    Genç, Zülfü; Aydemir, Emrah

    2015-01-01

    Purpose: The purpose of this study is to determine whether the use of online puzzles in the instructional process has an effect on student achievement and learning retention. This study examined students ' perception and experiences on use of puzzle as an alternative evaluation tool. To achieve this aim, the following hypotheses were tested: using…

  19. Crossword Puzzle Makes It Fun: Introduce Green Manufacturing in Wood Technology Courses

    ERIC Educational Resources Information Center

    Iley, John L.; Hague, Doug

    2012-01-01

    Sustainable, or "green," manufacturing and its practices are becoming more and more a part of today's industry, including wood product manufacturing. This article provides introductory information on green manufacturing in wood technology and a crossword puzzle based on green manufacturing terms. The authors use the puzzle at the college level to…

  20. Three- and Four-Year-Olds Completing 150-Piece Puzzles? Impossible!

    ERIC Educational Resources Information Center

    Barron, Marlene

    1999-01-01

    Documented strategies preschool children used in completing complex, multipiece puzzles, which included focus on color, design, or shape. Found that all children could benefit and enjoy working on larger puzzles in the classroom and that the activity encouraged social literacy, completing a long-term project, scaffolding, and child development.…

  1. Two-Dimensional Parson's Puzzles: The Concept, Tools, and First Observations

    ERIC Educational Resources Information Center

    Ihantola, Petri; Karavirta, Ville

    2011-01-01

    Parson's programming puzzles are a family of code construction assignments where lines of code are given, and the task is to form the solution by sorting and possibly selecting the correct code lines. We introduce a novel family of Parson's puzzles where the lines of code need to be sorted in two dimensions. The vertical dimension is used to order…

  2. Nonlinear analysis of wiggler-imperfections in free-electron lasers

    SciTech Connect

    Freund, H.P.; Yu, L.H.

    1995-12-31

    We present an analysis of the effect of wiggler imperfections in FELs using a variety of techniques. Our basic intention is to compare wiggler averaged nonlinear simulations to determine the effect of various approximations on the estimates of gain degradation due to wiggler imperfections. The fundamental assumption in the wiggler-averaged formulations is that the electrons are described by a random walk model, and an analytic representation of the orbits is made. This is fundamentally different from the approach taken for the non-wiggler-averaged formulation in which the wiggler imperfections are specified at the outset, and the orbits are integrated using a field model that is consistent with the Maxwell equations. It has been conjectured on the basis of prior studies using the non-wiggler-averaged formalism that electrons follow a {open_quotes}meander line{close_quotes} through the wiggler governed by the specific imperfections; hence, the electrons behave more as a ball-in-groove than as a random walk. This conjecture is tested by comparison of the wiggler-averaged and non-wiggler-averaged simulations. In addition, two different wiggler models are employed in the non-wiggler-averaged simulation: one based upon a parabolic pole face wiggler which is not curl and divergence free in the presence of wiggler imperfections, and a second model in which the divergence and z-component of the curl vanish identically. This will gauge the effect of inconsistencies in the wiggler model on the estimation of the effect of the imperfections. Preliminary results indicate that the inconsistency introduced by the non-vanishing curl and divergence result in an overestimation of the effect of wiggler imperfections on the orbit. The wiggler-averaged simulation is based upon the TDA code, and the non-wiggler-averaged simulation is a variant of the ARACHNE and WIGGLIN codes called MEDUSA developed to treat short-wavelength Gauss-Hermite modes.

  3. Evaluating the predictive abilities of community occupancy models using AUC while accounting for imperfect detection

    USGS Publications Warehouse

    Zipkin, Elise F.; Grant, Evan H. Campbell; Fagan, William F.

    2012-01-01

    The ability to accurately predict patterns of species' occurrences is fundamental to the successful management of animal communities. To determine optimal management strategies, it is essential to understand species-habitat relationships and how species habitat use is related to natural or human-induced environmental changes. Using five years of monitoring data in the Chesapeake and Ohio Canal National Historical Park, Maryland, USA, we developed four multi-species hierarchical models for estimating amphibian wetland use that account for imperfect detection during sampling. The models were designed to determine which factors (wetland habitat characteristics, annual trend effects, spring/summer precipitation, and previous wetland occupancy) were most important for predicting future habitat use. We used the models to make predictions of species occurrences in sampled and unsampled wetlands and evaluated model projections using additional data. Using a Bayesian approach, we calculated a posterior distribution of receiver operating characteristic area under the curve (ROC AUC) values, which allowed us to explicitly quantify the uncertainty in the quality of our predictions and to account for false negatives in the evaluation dataset. We found that wetland hydroperiod (the length of time that a wetland holds water) as well as the occurrence state in the prior year were generally the most important factors in determining occupancy. The model with only habitat covariates predicted species occurrences well; however, knowledge of wetland use in the previous year significantly improved predictive ability at the community level and for two of 12 species/species complexes. Our results demonstrate the utility of multi-species models for understanding which factors affect species habitat use of an entire community (of species) and provide an improved methodology using AUC that is helpful for quantifying the uncertainty in model predictions while explicitly accounting for

  4. The problem of the imperfection of a world, itself created by a perfect god

    NASA Astrophysics Data System (ADS)

    Mercier, André

    1992-02-01

    The two main arguments concern (1) the presence of an “enlightened complementarity” between philosophic (including scientific) and religious ( not including mystic) thought, and (2) the necessity to postulate a “threefold relationship” whenever one is to gain knowledge of any kind. They are both inspired by physics (from Bohr's “strict complementarity”, resp. from Newton's fundamental postulate). God's perfection resides at least in Symmetry in a generalized (not restrictively spatial) sense. Yet, as the argument goes, Space does not “exist” as a thing. Consequently, the Great Geometer (God) cannot dwell within a World He creates, and it is wrong to speak about His (God's) ‘existence’; for, existence is bound to the temporal, and Time is, together with the World, part of God's creation. Thus the only possible creation consists in God separating World and Time from Himself: This is the paradigm of Symmetry-breaking. Polytheistic mythologies all assume such and such imperfection of their deities; hence perfection is meaningful for monotheism only. A relationship of a threefold (‘trinitary’) nature must then obtain between God, World, and Time; this is analogous to Newton's postulate relating force, momentum and time. Just as the latter and its specific generalizations must be “found true” by verification, the said threefold relationship must also be found true: within philosophic thought more geometrico (in a generalized sense), within religious thought more “hymnometrico”. Yet the complementarity (called “enlightened”) arising between the two kinds of thought is of a higher nature than Bohr's “strict” complementarity. While it can be understood from the role assumed by language itself, it can however only be disposed of within mystic contemplation.

  5. Verb Aspect and the Activation of Event Knowledge

    ERIC Educational Resources Information Center

    Ferretti, Todd R.; Kutas, Marta; McRae, Ken

    2007-01-01

    The authors show that verb aspect influences the activation of event knowledge with 4 novel results. First, common locations of events (e.g., arena) are primed following verbs with imperfective aspect (e.g., was skating) but not verbs with perfect aspect (e.g., had skated). Second, people generate more locative prepositional phrases as…

  6. An Empirical Evaluation of Puzzle-Based Learning as an Interest Approach for Teaching Introductory Computer Science

    ERIC Educational Resources Information Center

    Merrick, K. E.

    2010-01-01

    This correspondence describes an adaptation of puzzle-based learning to teaching an introductory computer programming course. Students from two offerings of the course--with and without the puzzle-based learning--were surveyed over a two-year period. Empirical results show that the synthesis of puzzle-based learning concepts with existing course…

  7. Probabilistic Interpretation of Peelle's Pertinent Puzzle and its Resolution

    SciTech Connect

    Hanson, Kenneth M.; Kawano, Toshihiko; Talou, Patrick

    2005-05-24

    Peelle's Pertinent Puzzle (PPP) states a seemingly plausible set of measurements with their covariance matrix, which produce an implausible answer. To answer the PPP question, we describe a reasonable experimental situation that is consistent with the PPP solution. The confusion surrounding the PPP arises in part because of its imprecise statement, which permits to a variety of interpretations and resulting answers, some of which seem implausible. We emphasize the importance of basing the analysis on an unambiguous probabilistic model that reflects the experimental situation. We present several different models of how the measurements quoted in the PPP problem could be obtained, and interpret their solution in terms of a detailed probabilistic analysis. We suggest a probabilistic approach to handling uncertainties about which model to use.

  8. Probabilistic interpretation of Peelle's pertinent puzzle and its resolution

    SciTech Connect

    Hanson, Kenneth M.; Kawano, T.; Talou, P.

    2004-01-01

    Peelle's Pertinent Puzzle (PPP) states a seemingly plausible set of measurements with their covariance matrix, which produce an implausible answer. To answer the PPP question, we describe a reasonable experimental situation that is consistent with the PPP solution. The confusion surrounding the PPP arises in part because of its imprecise statement, which permits to a variety of interpretations and resulting answers, some of which seem implausible. We emphasize the importance of basing the analysis on an unambiguous probabilistic model that reflects the experimental situation. We present several different models of how the measurements quoted in the PPP problem could be obtained, and interpret their solution in terms of a detailed probabilistic analysis. We suggest a probabilistic approach to handling uncertainties about which model to use.

  9. Peelle's pertinent puzzle using the Monte Carlo technique

    SciTech Connect

    Kawano, Toshihiko; Talou, Patrick; Burr, Thomas; Pan, Feng

    2009-01-01

    We try to understand the long-standing problem of the Peelle's Pertinent Puzzle (PPP) using the Monte Carlo technique. We allow the probability density functions to be any kind of form to assume the impact of distribution, and obtain the least-squares solution directly from numerical simulations. We found that the standard least squares method gives the correct answer if a weighting function is properly provided. Results from numerical simulations show that the correct answer of PPP is 1.1 {+-} 0.25 if the common error is multiplicative. The thought-provoking answer of 0.88 is also correct, if the common error is additive, and if the error is proportional to the measured values. The least squares method correctly gives us the most probable case, where the additive component has a negative value. Finally, the standard method fails for PPP due to a distorted (non Gaussian) joint distribution.

  10. Four Small Puzzles That Rosetta Doesn't Solve

    PubMed Central

    Das, Rhiju

    2011-01-01

    A complete macromolecule modeling package must be able to solve the simplest structure prediction problems. Despite recent successes in high resolution structure modeling and design, the Rosetta software suite fares poorly on small protein and RNA puzzles, some as small as four residues. To illustrate these problems, this manuscript presents Rosetta results for four well-defined test cases: the 20-residue mini-protein Trp cage, an even smaller disulfide-stabilized conotoxin, the reactive loop of a serine protease inhibitor, and a UUCG RNA tetraloop. In contrast to previous Rosetta studies, several lines of evidence indicate that conformational sampling is not the major bottleneck in modeling these small systems. Instead, approximations and omissions in the Rosetta all-atom energy function currently preclude discriminating experimentally observed conformations from de novo models at atomic resolution. These molecular “puzzles” should serve as useful model systems for developers wishing to make foundational improvements to this powerful modeling suite. PMID:21625446

  11. Precision Spectroscopy of Atomic Hydrogen and the Proton Size Puzzle

    NASA Astrophysics Data System (ADS)

    Udem, Thomas

    2016-05-01

    Precise determination of transition frequencies of simple atomic systems are required for a number of fundamental applications such as tests of quantum electrodynamics (QED), the determination of fundamental constants and nuclear charge radii. The sharpest transition in atomic hydrogen occurs between the metastable 2S state and the 1S ground state. Its transition frequency has now been measured with almost 15 digits accuracy using an optical frequency comb and a cesium atomic clock as a reference. A recent measurement of the Lamb shift in muonic hydrogen is in significant contradiction to the hydrogen data if QED calculations are assumed to be correct. We hope to contribute to the resolution of this so called `proton size puzzle' by providing additional experimental input from the hydrogen side.

  12. The puzzle of Muslim advantage in child survival in India.

    PubMed

    Bhalotra, Sonia; Valente, Christine; van Soest, Arthur

    2010-03-01

    The socioeconomic status of Indian Muslims is, on average, considerably lower than that of upper-caste Hindus. Muslims nevertheless exhibit substantially higher child survival rates, and have done for decades. This paper analyses this seeming puzzle. A decomposition of the survival differential confirms that some compositional effects favour Muslims but that, overall, differences in characteristics and especially the Muslim deficit in parental education predict a Muslim disadvantage. The results of this study contribute to a recent literature that debates the importance of socioeconomic status (SES) in determining health and survival. They augment a growing literature on the role of religion or culture as encapsulating important unobservable behaviours or endowments that influence health, indeed, enough to reverse the SES gradient that is commonly observed. PMID:19969383

  13. Possible resolution of the strange quark polarization puzzle?

    NASA Astrophysics Data System (ADS)

    Leader, Elliot; Sidorov, Alexander V.; Stamenov, Dimiter B.

    2011-07-01

    The strange quark polarization puzzle, i.e. the contradiction between the negative polarized strange quark density obtained from analyses of inclusive deep inelastic scattering data and the positive values obtained from combined analyses of inclusive and semi-inclusive deep inelastic scattering data using de Florian, Sassot, Stratmann fragmentation functions, is discussed. To this end the results of a new combined next-to-leading order QCD analysis of the polarized inclusive and semi-inclusive deep inelastic scattering data, using the Hirai, Kumano, Nagai, Sudoh (HKNS) fragmentation functions, are presented. It is demonstrated that the polarized strange quark density is very sensitive to the kaon fragmentation functions, and if the set of HKNS fragmentation functions is used, the polarized strange quark density obtained from the combined analysis turns out to be negative and well consistent with values obtained from the pure deep inelastic scattering analyses.

  14. The puzzling reliability of the Force Concept Inventory

    NASA Astrophysics Data System (ADS)

    Lasry, Nathaniel; Rosenfield, Steven; Dedic, Helena; Dahan, Ariel; Reshef, Orad

    2011-09-01

    The Force Concept Inventory (FCI) has influenced the development of many research-based pedagogies. However, no data exists on the FCI's internal consistency or test-retest reliability. The FCI was administered twice to one hundred students during the first week of classes in an electricity and magnetism course with no review of mechanics between test administrations. High Kuder-Richardson reliability coefficient values, which estimate the average correlation of scores obtained on all possible halves of the test, suggest strong internal consistency. However, 31% of the responses changed from test to retest, suggesting weak reliability for individual questions. A chi-square analysis shows that change in responses was neither consistent nor completely random. The puzzling conclusion is that although individual FCI responses are not reliable, the FCI total score is highly reliable.

  15. A Jigsaw Puzzle Layer Cake of Spatial Data

    NASA Astrophysics Data System (ADS)

    Ma, Xiaogang; Fox, Peter

    2014-05-01

    The Infrastructure for Spatial Information in Europe (INSPIRE; http://inspire.jrc.ec.europa.eu) is a European Union (EU) directive that aims to provide a legal framework to share environmental spatial data among public sector organizations across Europe and to facilitate public access to data. To meet these goals, INSPIRE's organization is analogous to a layer cake in which each layer is composed of interlocking pieces of a jigsaw puzzle. The metaphor, although mixed, is apt (see additional supporting information in the online version of this article), and as researchers outside the program, we offer our perspective on how INSPIRE may address challenges raised by the variety of data themes and the wide coverage of collaborators.

  16. Production inventory policies for defective items with inspection errors, sales return, imperfect rework process and backorders

    NASA Astrophysics Data System (ADS)

    Jaggi, Chandra K.; Khanna, Aditi; Kishore, Aakanksha

    2016-03-01

    In order to sustain the challenges of maintaining good quality and perfect screening process, rework process becomes a rescue to compensate for the imperfections present in the production system. The proposed model attempts to explore the existing real-life situation with a more practical approach by incorporating the concept of imperfect rework as this occurs as an unavoidable problem to the firm due to irreparable disorders even in the reworked items. Hence, a production inventory model is formulated here to study the combined effect of imperfect quality items, faulty inspection process and imperfect rework process on the optimal production quantity and optimal backorder level. An analytical method is employed to maximize the expected total profit per unit time. Moreover, the results of several previous research articles namely Chiu et al (2006), Chiu et al (2005), Salameh and Hayek (2001), and classical EPQ with shortages are deduced as special cases. To demonstrate the applicability of the model, and to observe the effects of key parameters on the optimal replenishment policy, a numerical example along with a comprehensive sensitivity analysis has been presented. The pertinence of the model can be found in most of the manufacturing industries like textile, electronics, furniture, footwear, plastics etc. A production lot size model has been explored for defectives items with inspection errors and an imperfect rework process.

  17. Effects of Imperfections on the Buckling Response of Compression-Loaded Composite Shells

    NASA Technical Reports Server (NTRS)

    Hilburger, Mark W.; Starnes, James H., Jr.

    2000-01-01

    The results of an experimental and numerical study of the effects of imperfections on the buckling response of unstiffened thin-walled composite cylindrical shells are presented. Results that identify the individual and combined effects of traditional initial geometric shell-wall imperfections and non-traditional shell-wall thickness variations, shell-end geometric imperfections and variations in loads applied to the ends of the shells on the shell buckling response are included. In addition, results illustrating the effects of manufacturing flaws in the form of gaps between adjacent pieces of graphite-epoxy tape in some of the laminate plies are presented in detail. The shells have been analyzed with a nonlinear finite-element analysis code that accurately accounts for these effects on the buckling and nonlinear responses of the shells. The numerical results indicate that traditional and nontraditional initial imperfections can cause a significant reduction in the buckling load of a compression-loaded composite shell. Furthermore, the results indicate that the imperfections couple in a nonlinear manner. The numerical results correlate well with the experimental results. The nonlinear analysis results are also compared to the results from a traditional linear bifurcation buckling analysis. The results suggest that the nonlinear analysis procedure can be used for determining accurate, high-fidelity design knockdown factors for shell buckling and collapse. The results can also be used to determine the effects of manufacturing tolerances on the buckling response of composite shells.

  18. Scattering effects induced by imperfections on an acoustic black hole placed at a structural waveguide termination

    NASA Astrophysics Data System (ADS)

    Denis, V.; Pelat, A.; Gautier, F.

    2016-02-01

    The so-called "acoustic black hole" (ABH) effect is a passive vibration control technique based on the flexural waves properties in thin structure of varying thickness. A usual implementation consists in using a plate with tapered extremity with a power-law profile, covered with a thin damping layer. The inhomogeneity of the structure leads to a decrease of flexural wave speed and an increase of their amplitude, therefore resulting in an efficient energy dissipation if damping layer is placed where the thickness is minimal. The manufacture of an efficient extremity is difficult because of the small thickness, and often generates imperfections and tearing. Moreover, previous works suggest that multiple flexural modes are propagating across the width of the ABH tip. A model of an ABH multimodal waveguide taking into account an imperfect termination is developed. It shows that an elementary imperfection can affect the reflection coefficient of the extremity and reduce it. Scattering and propagation properties of the extremity are also studied. An incident mode excites several modes that are localised in the tapered region and local resonances explain the drops in the reflection coefficient. Experimental evidence of the influence of the imperfection on the reflection coefficient is provided. A key result of the paper is that manufacturing imperfections are not detrimental to the ABH effect.

  19. Accounting for Imperfect Detection Is Critical for Inferring Marine Turtle Nesting Population Trends

    PubMed Central

    Pfaller, Joseph B.; Bjorndal, Karen A.; Chaloupka, Milani; Williams, Kristina L.; Frick, Michael G.; Bolten, Alan B.

    2013-01-01

    Assessments of population trends based on time-series counts of individuals are complicated by imperfect detection, which can lead to serious misinterpretations of data. Population trends of threatened marine turtles worldwide are usually based on counts of nests or nesting females. We analyze 39 years of nest-count, female-count, and capture-mark-recapture (CMR) data for nesting loggerhead turtles (Caretta caretta) on Wassaw Island, Georgia, USA. Annual counts of nests and females, not corrected for imperfect detection, yield significant, positive trends in abundance. However, multistate open robust design modeling of CMR data that accounts for changes in imperfect detection reveals that the annual abundance of nesting females has remained essentially constant over the 39-year period. The dichotomy could result from improvements in surveys or increased within-season nest-site fidelity in females, either of which would increase detection probability. For the first time in a marine turtle population, we compare results of population trend analyses that do and do not account for imperfect detection and demonstrate the potential for erroneous conclusions. Past assessments of marine turtle population trends based exclusively on count data should be interpreted with caution and re-evaluated when possible. These concerns apply equally to population assessments of all species with imperfect detection. PMID:23638041

  20. Thermo-electro-mechanical postbuckling of piezoelectric FG-CNTRC beams with geometric imperfections

    NASA Astrophysics Data System (ADS)

    Wu, Helong; Kitipornchai, Sritawat; Yang, Jie

    2016-09-01

    This paper presents thermo-electro-mechanical postbuckling analysis of geometrically imperfect functionally graded carbon nanotube-reinforced composite (FG-CNTRC) hybrid beams that are integrated with surface-bonded piezoelectric actuators. The material properties of FG-CNTRCs are assumed to be temperature-dependent and graded in the thickness direction. By using a generic imperfection function, various possible imperfections with different shapes and locations in the beam are considered. The theoretical formulations are based on the first-order shear deformation beam theory with von-Kármán nonlinearity. A differential quadrature approximation based iteration process is employed to obtain the postbuckling equilibrium path of piezoelectric FG-CNTRC hybrid beams under thermo-electro-mechanical loading. Parametric studies are conducted to examine the effect of geometric imperfection, distribution pattern and volume fraction of carbon nanotubes, temperature rise, actuator voltage, beam geometry and boundary conditions on the thermo-electro-mechanical postbuckling behaviour. The results show that the thermo-electro-mechanical postbuckling is considerably affected by the imperfection mode, half-wave number, location and amplitude, as well as the temperature rise and boundary conditions. The effect of applied actuator voltage is much less pronounced but tends to be relatively more noticeable as the slenderness ratio increases.

  1. Beyond Knowledge: Exploring Why Some Teachers Are More Thoughtfully Adaptive than Others

    ERIC Educational Resources Information Center

    Fairbanks, Colleen M.; Duffy, Gerald G.; Faircloth, Beverly S.; He, Ye; Levin, Barbara; Rohr, Jean; Stein, Catherine

    2010-01-01

    As teacher educators, we have observed that knowledge alone does not lead to the kinds of thoughtful teaching we strive for. Puzzled by differences in the teaching practices of teacher candidates having similar professional knowledge, we explore what might account for these differences. We address what is necessary, beyond traditional forms of…

  2. Propagation of SH waves in a piezoelectric/piezomagnetic plate: Effects of interfacial imperfection couplings and the related physical mechanisms

    NASA Astrophysics Data System (ADS)

    Wei, Hong-Xing; Li, Yong-Dong; Xiong, Tao; Guan, Yong

    2016-09-01

    The problem of dispersive SH wave in a piezoelectric/piezomagnetic plate that contains an imperfect interface is considered in the present work. An imperfection coupling model is adopted to describe the magnetic, electric and mechanical imperfections on the interface. A transcendental dispersion equation is derived and numerically solved to get the phase velocity. The validity of the numerical procedure is verified in a degenerated case. The effects of the coupled interfacial imperfections on the dispersion behavior of SH waves are discussed in detail and the related underlying physical mechanisms are explained.

  3. Maximum likelihood estimation of label imperfections and its use in the identification of mislabeled patterns

    NASA Technical Reports Server (NTRS)

    Chittineni, C. B.

    1979-01-01

    The problem of estimating label imperfections and the use of the estimation in identifying mislabeled patterns is presented. Expressions for the maximum likelihood estimates of classification errors and a priori probabilities are derived from the classification of a set of labeled patterns. Expressions also are given for the asymptotic variances of probability of correct classification and proportions. Simple models are developed for imperfections in the labels and for classification errors and are used in the formulation of a maximum likelihood estimation scheme. Schemes are presented for the identification of mislabeled patterns in terms of threshold on the discriminant functions for both two-class and multiclass cases. Expressions are derived for the probability that the imperfect label identification scheme will result in a wrong decision and are used in computing thresholds. The results of practical applications of these techniques in the processing of remotely sensed multispectral data are presented.

  4. A long persistent phosphor based on recombination centers originating from Zn imperfections.

    PubMed

    Li, Yang; Du, Xi; Sharafudeen, Kaniyarakkal; Liao, Chenxing; Qiu, Jianrong

    2014-04-01

    The recombination luminescence from Zn imperfections has been extensively investigated; however, there have been few reports on the long persistent luminescence of Zn imperfections as emitting centers. Here, we observed a long persistent luminescence in blue-white visible region from 6 ZnO:3 GeO2:Al2O3 phosphor with Zn imperfections as emitting centers. Persistent luminescence could be observed beyond 2h with naked eyes. The properties of traps were also elaborated by the measurements of thermo-luminescence spectra and photo-stimulated luminescence decay curves. Furthermore, a long persistent phosphor with warm white color was developed by doping Cr(3+) into 6 ZnO:3 GeO2:Al2O3 phosphor. PMID:24388995

  5. Homogenized finite element analysis on effective elastoplastic mechanical behaviors of composite with imperfect interfaces.

    PubMed

    Jiang, Wu-Gui; Zhong, Ren-Zhi; Qin, Qing H; Tong, Yong-Gang

    2014-01-01

    A three-dimensional (3D) representative volume element (RVE) model was developed for analyzing effective mechanical behavior of fiber-reinforced ceramic matrix composites with imperfect interfaces. In the model, the fiber is assumed to be perfectly elastic until its tensile strength, and the ceramic material is modeled by an elasto-plastic Drucker-Prager constitutive law. The RVE model is then used to study the elastic properties and the tensile strength of composites with imperfect interfaces and validated through experiments. The imperfect interfaces between the fiber and the matrix are taken into account by introducing some cohesive contact surfaces. The influences of the interface on the elastic constants and the tensile strengths are examined through these interface models. PMID:25522170

  6. Generalizing Kant's distinction between perfect and imperfect duties to trust in different situations.

    PubMed

    Rice, Stephen; Trafimow, David; Hunt, Gayle; Sandry, Joshua

    2010-01-01

    Based on previous research that violations of perfect duties cause stronger correspondent inferences than violations of imperfect ones, the authors performed four experiments to generalize this effect to trust. In Experiment 1, abstract violations of perfect duties resulted in less trust than violations of imperfect ones for specific trust scenarios. In Experiments 2 and 3, the authors experimented with different levels of abstractness of the duty violations and obtained similar effects. Experiment 4 was concerned with generalizing further--from duty violations in one situation to trust in a different situation. Although mostly consistent with the findings from Experiments 1-3, the data also demonstrated partial generalization for violations of both perfect and imperfect duties. PMID:20198814

  7. Homogenized Finite Element Analysis on Effective Elastoplastic Mechanical Behaviors of Composite with Imperfect Interfaces

    PubMed Central

    Jiang, Wu-Gui; Zhong, Ren-Zhi; Qin, Qing H.; Tong, Yong-Gang

    2014-01-01

    A three-dimensional (3D) representative volume element (RVE) model was developed for analyzing effective mechanical behavior of fiber-reinforced ceramic matrix composites with imperfect interfaces. In the model, the fiber is assumed to be perfectly elastic until its tensile strength, and the ceramic material is modeled by an elasto-plastic Drucker-Prager constitutive law. The RVE model is then used to study the elastic properties and the tensile strength of composites with imperfect interfaces and validated through experiments. The imperfect interfaces between the fiber and the matrix are taken into account by introducing some cohesive contact surfaces. The influences of the interface on the elastic constants and the tensile strengths are examined through these interface models. PMID:25522170

  8. Algorithm for the Evaluation of Imperfections in Auto Bodywork Using Profiles from a Retroreflective Image

    PubMed Central

    Barber, Ramon; Zwilling, Valerie; Salichs, Miguel A.

    2014-01-01

    Nowadays the automobile industry is becoming more and more demanding as far as quality is concerned. Within the wide variety of processes in which this quality must be ensured, those regarding the squeezing of the auto bodywork are especially important due to the fact that the quality of the resulting product is tested manually by experts, leading to inaccuracies of all types. In this paper, an algorithm is proposed for the automated evaluation of the imperfections in the sheets of the bodywork after the squeezing process. The algorithm processes the profile signals from a retroreflective image and characterizes an imperfection. It is based on a convergence criterion that follows the line of the maximum gradient of the imperfection and gives its geometrical characteristics as a result: maximum gradient, length, width, and area. PMID:24504105

  9. The psychology of coordination and common knowledge.

    PubMed

    Thomas, Kyle A; DeScioli, Peter; Haque, Omar Sultan; Pinker, Steven

    2014-10-01

    Research on human cooperation has concentrated on the puzzle of altruism, in which 1 actor incurs a cost to benefit another, and the psychology of reciprocity, which evolved to solve this problem. We examine the complementary puzzle of mutualism, in which actors can benefit each other simultaneously, and the psychology of coordination, which ensures such benefits. Coordination is facilitated by common knowledge: the recursive belief state in which A knows X, B knows X, A knows that B knows X, B knows that A knows X, ad infinitum. We test whether people are sensitive to common knowledge when deciding whether to engage in risky coordination. Participants decided between working alone for a certain profit and working together for a potentially higher profit that they would receive only if their partner made the same choice. Results showed that more participants attempted risky coordination when they and their prospective partner had common knowledge of the payoffs (broadcast over a loudspeaker) than when they had only shared knowledge (conveyed to both by a messenger) or private knowledge (revealed to each partner separately). These results support the hypothesis that people represent common knowledge as a distinct cognitive category that licenses them to coordinate with others for mutual gain. We discuss how this hypothesis can provide a unified explanation for diverse phenomena in human social life, including recursive mentalizing, performative speech acts, public protests, hypocrisy, and self-conscious emotional expressions. PMID:25111301

  10. Synchronizing spatio-temporal chaos with imperfect models: A stochastic surface growth picture

    SciTech Connect

    Pazó, Diego López, Juan M.; Rodríguez, Miguel A.; Gallego, Rafael

    2014-12-01

    We study the synchronization of two spatially extended dynamical systems where the models have imperfections. We show that the synchronization error across space can be visualized as a rough surface governed by the Kardar-Parisi-Zhang equation with both upper and lower bounding walls corresponding to nonlinearities and model discrepancies, respectively. Two types of model imperfections are considered: parameter mismatch and unresolved fast scales, finding in both cases the same qualitative results. The consistency between different setups and systems indicates that the results are generic for a wide family of spatially extended systems.

  11. Postbuckling analysis of shear deformable composite flat panels taking into account geometrical imperfections

    NASA Technical Reports Server (NTRS)

    Librescu, L.; Stein, M.

    1990-01-01

    The effects of initial geometrical imperfections on the postbuckling response of flat laminated composite panels to uniaxial and biaxial compressive loading are investigated analytically. The derivation of the mathematical model on the basis of first-order transverse shear deformation theory is outlined, and numerical results for perfect and imperfect, single-layer and three-layer square plates with free-free, clamped-clamped, or free-clamped edges are presented in graphs and briefly characterized. The present approach is shown to be more accurate than analyses based on the classical Kirchhoff plate model.

  12. A 15N CPMG relaxation dispersion experiment more resistant to resonance offset and pulse imperfection

    NASA Astrophysics Data System (ADS)

    Jiang, Bin; Yu, Binhan; Zhang, Xu; Liu, Maili; Yang, Daiwen

    2015-08-01

    Carr-Purcell-Meiboom-Gill (CPMG) relaxation dispersion is a powerful NMR method to study protein dynamics on the microsecond-millisecond time scale. J-coupling, resonance offset, radio frequency field inhomogeneity, and pulse imperfection often introduce systematic errors into the measured transverse relaxation rates. Here we proposed a modified continuous wave decoupling CPMG experiment, which is more unaffected by resonance offset and pulse imperfection. We found that it is unnecessary to match the decoupling field strength with the delay between CPMG refocusing pulses, provided that decoupling field is strong enough. The performance of the scheme proposed here was shown by simulations and further demonstrated experimentally on a fatty acid binding protein.

  13. Strangeness in neutron star matter: a challenging puzzle

    NASA Astrophysics Data System (ADS)

    Lonardoni, Diego; Lovato, Alessandro; Gandolfi, Stefano; Pederiva, Francesco

    2014-09-01

    The onset of strange baryons in the core of neutron stars and the consequent softening of the equation of state have been questioned for a long time. Controversial theoretical predictions about the predicted maximum mass and the recent astrophysical observations are the grounds of the so called hyperon puzzle. We attempt to give our contribution to the discussion by studying the general problem of the hyperon-nucleon interaction by means of Auxiliary Field Diffusion Monte Carlo calculations. We employ a phenomenological approach showing that a three-body hyperon-nucleon force provides the strong repulsive contribution needed to correctly describe the systematics of medium-light Λ hypernuclei. The same potential has been used to determine the equation of state and the mass-radius relation of an infinite systems of neutrons and Λ particles. We find that the three-body hyperon-nucleon force has a dramatic effect on the equation of state and the predicted maximum mass. Our results suggest that more constraints on the nature of hyperon-neutron forces are needed before drawing any conclusion on the role played by hyperons in neutron stars. The onset of strange baryons in the core of neutron stars and the consequent softening of the equation of state have been questioned for a long time. Controversial theoretical predictions about the predicted maximum mass and the recent astrophysical observations are the grounds of the so called hyperon puzzle. We attempt to give our contribution to the discussion by studying the general problem of the hyperon-nucleon interaction by means of Auxiliary Field Diffusion Monte Carlo calculations. We employ a phenomenological approach showing that a three-body hyperon-nucleon force provides the strong repulsive contribution needed to correctly describe the systematics of medium-light Λ hypernuclei. The same potential has been used to determine the equation of state and the mass-radius relation of an infinite systems of neutrons and

  14. Clauser-Horne Bell test with imperfect random inputs

    NASA Astrophysics Data System (ADS)

    Yuan, Xiao; Zhao, Qi; Ma, Xiongfeng

    2015-08-01

    The Bell test is one of the most important tools in quantum information science. On the one hand, it enables fundamental tests of the basic physics laws of nature, and on the other hand, it can also be applied in a variety of device-independent tasks such as quantum key distribution and random number generation. In practice, loopholes existing in experimental demonstrations of Bell tests may affect the validity of the conclusions. In this work, we focus on the randomness (freewill) loophole and investigate the randomness requirement in a well-known Bell test, the Clauser-Horne test, under various conditions. We explicitly bound the Bell value for all local hidden variable models by optimizing over all classical strategies exploiting the knowledge of the partially random inputs. Our result thus provides input randomness requirements on the Clauser-Horne test under varieties of practical scenarios. The employed analysis technique can also be generalized to other Bell inequalities.

  15. A Play on Words: Using Cognitive Computing as a Basis for AI Solvers in Word Puzzles

    NASA Astrophysics Data System (ADS)

    Manzini, Thomas; Ellis, Simon; Hendler, James

    2015-12-01

    In this paper we offer a model, drawing inspiration from human cognition and based upon the pipeline developed for IBM's Watson, which solves clues in a type of word puzzle called syllacrostics. We briefly discuss its situation with respect to the greater field of artificial general intelligence (AGI) and how this process and model might be applied to other types of word puzzles. We present an overview of a system that has been developed to solve syllacrostics.

  16. Imperfect or Perfect Dynamic Bipolarity? The Case of Antonymous Affective Judgments

    ERIC Educational Resources Information Center

    Vautier, Stephane; Steyer, Rolf; Jmel, Said; Raufaste, Eric

    2005-01-01

    How is affective change rated with positive adjectives such as good related to change rated with negative adjectives such as bad? Two nested perfect and imperfect forms of dynamic bipolarity are defined using latent change structural equation models based on tetrads of items. Perfect bipolarity means that latent change scores correlate -1.…

  17. Security analysis on some experimental quantum key distribution systems with imperfect optical and electrical devices

    NASA Astrophysics Data System (ADS)

    Liang, Lin-Mei; Sun, Shi-Hai; Jiang, Mu-Sheng; Li, Chun-Yan

    2014-10-01

    In general, quantum key distribution (QKD) has been proved unconditionally secure for perfect devices due to quantum uncertainty principle, quantum noncloning theorem and quantum nondividing principle which means that a quantum cannot be divided further. However, the practical optical and electrical devices used in the system are imperfect, which can be exploited by the eavesdropper to partially or totally spy the secret key between the legitimate parties. In this article, we first briefly review the recent work on quantum hacking on some experimental QKD systems with respect to imperfect devices carried out internationally, then we will present our recent hacking works in details, including passive faraday mirror attack, partially random phase attack, wavelength-selected photon-number-splitting attack, frequency shift attack, and single-photon-detector attack. Those quantum attack reminds people to improve the security existed in practical QKD systems due to imperfect devices by simply adding countermeasure or adopting a totally different protocol such as measurement-device independent protocol to avoid quantum hacking on the imperfection of measurement devices [Lo, et al., Phys. Rev. Lett., 2012, 108: 130503].

  18. Intrinsic hierarchical structural imperfections in a natural ceramic of bivalve shell with distinctly graded properties

    PubMed Central

    Jiao, Da; Liu, Zengqian; Zhang, Zhenjun; Zhang, Zhefeng

    2015-01-01

    Despite the extensive investigation on the structure of natural biological materials, insufficient attention has been paid to the structural imperfections by which the mechanical properties of synthetic materials are dominated. In this study, the structure of bivalve Saxidomus purpuratus shell has been systematically characterized quantitatively on multiple length scales from millimeter to sub-nanometer. It is revealed that hierarchical imperfections are intrinsically involved in the crossed-lamellar structure of the shell despite its periodically packed platelets. In particular, various favorable characters which are always pursued in synthetic materials, e.g. nanotwins and low-angle misorientations, have been incorporated herein. The possible contributions of these imperfections to mechanical properties are further discussed. It is suggested that the imperfections may serve as structural adaptations, rather than detrimental defects in the real sense, to help improve the mechanical properties of natural biological materials. This study may aid in understanding the optimizing strategies of structure and properties designed by nature, and accordingly, provide inspiration for the design of synthetic materials. PMID:26198844

  19. On Crosslinguistic Variations in Imperfective Aspect: The Case of L2 Korean

    ERIC Educational Resources Information Center

    Lee, EunHee; Kim, Hae-Young

    2007-01-01

    This article examines the acquisition of Korean imperfective markers, the progressive "-ko iss-" and the resultative "-a iss-," with a view to understanding how tense/aspect morphology expands beyond prototype associations with inherent aspects of the verbs. We hypothesized that "-a iss-" will develop later than "-ko iss-," but that the…

  20. Nonlinear dynamics of initially imperfect functionally graded circular cylindrical shell under complex loads

    NASA Astrophysics Data System (ADS)

    Liu, Y. Z.; Hao, Y. X.; Zhang, W.; Chen, J.; Li, S. B.

    2015-07-01

    The nonlinear vibration of a simply supported FGM cylindrical shell with small initial geometric imperfection under complex loads is studied. The effects of radial harmonic excitation, compressive in-plane force combined with supersonic aerodynamic and thermal loads are considered. The small initial geometric imperfection of the cylindrical shell is characterized in the form of the sine-type trigonometric functions. The effective material properties of this FGM cylindrical shell are graded in the radial direction according to a simple power law in terms of the volume fractions. Based on Reddy's third-order shear deformation theory, von Karman-type nonlinear kinematics and Hamilton's principle, the nonlinear partial differential equation that controls the shell dynamics is derived. Both axial symmetric and driven modes of the cylindrical shell deflection pattern are included. Furthermore, the equations of motion can be reduced into a set of coupled nonlinear ordinary differential equations by applying Galerkin's method. In the study of the nonlinear dynamics responses of small initial geometric imperfect FGM cylindrical shell under complex loads, the 4th order Runge-Kutta method is used to obtain time history, phase portraits, bifurcation diagrams and Poincare maps with different parameters. The effects of external loads, geometric imperfections and volume fractions on the nonlinear dynamics of the system are discussed.

  1. Let Cinderella and Luke Skywalker Help You Teach the Passe Compose and Imperfect.

    ERIC Educational Resources Information Center

    Terry, Robert M.

    Instructional materials for the passe compose and imperfect tenses in French use the technique of presenting familiar stories in the foreign language, written in the present tense, which students must place in the past by changing verb forms. The objective is to avoid the disadvantages of simply translating verb tenses and to allow the student to…

  2. Free vibration of thermally loaded panels including initial imperfections and post-buckling effects

    NASA Technical Reports Server (NTRS)

    Murphy, K. D.; Virgin, L. N.; Rizzi, S. A.

    1994-01-01

    A combined theoretical and experimental approach is developed to consider the small amplitude free vibration characteristics of fully clamped panels under the influence of uniform heating. Included in this study are the effects of higher modes, in-plane boundary elasticity, initial imperfections, and post-buckling. Comparisons between theory and experiment reveal excellent agreement.

  3. 49 CFR 192.713 - Transmission lines: Permanent field repair of imperfections and damages.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 3 2014-10-01 2014-10-01 false Transmission lines: Permanent field repair of...) PIPELINE SAFETY TRANSPORTATION OF NATURAL AND OTHER GAS BY PIPELINE: MINIMUM FEDERAL SAFETY STANDARDS Maintenance § 192.713 Transmission lines: Permanent field repair of imperfections and damages. (a)...

  4. 49 CFR 192.713 - Transmission lines: Permanent field repair of imperfections and damages.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 3 2010-10-01 2010-10-01 false Transmission lines: Permanent field repair of...) PIPELINE SAFETY TRANSPORTATION OF NATURAL AND OTHER GAS BY PIPELINE: MINIMUM FEDERAL SAFETY STANDARDS Maintenance § 192.713 Transmission lines: Permanent field repair of imperfections and damages. (a)...

  5. 49 CFR 192.713 - Transmission lines: Permanent field repair of imperfections and damages.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 3 2011-10-01 2011-10-01 false Transmission lines: Permanent field repair of...) PIPELINE SAFETY TRANSPORTATION OF NATURAL AND OTHER GAS BY PIPELINE: MINIMUM FEDERAL SAFETY STANDARDS Maintenance § 192.713 Transmission lines: Permanent field repair of imperfections and damages. (a)...

  6. 49 CFR 192.713 - Transmission lines: Permanent field repair of imperfections and damages.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 3 2012-10-01 2012-10-01 false Transmission lines: Permanent field repair of...) PIPELINE SAFETY TRANSPORTATION OF NATURAL AND OTHER GAS BY PIPELINE: MINIMUM FEDERAL SAFETY STANDARDS Maintenance § 192.713 Transmission lines: Permanent field repair of imperfections and damages. (a)...

  7. 49 CFR 192.713 - Transmission lines: Permanent field repair of imperfections and damages.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 3 2013-10-01 2013-10-01 false Transmission lines: Permanent field repair of...) PIPELINE SAFETY TRANSPORTATION OF NATURAL AND OTHER GAS BY PIPELINE: MINIMUM FEDERAL SAFETY STANDARDS Maintenance § 192.713 Transmission lines: Permanent field repair of imperfections and damages. (a)...

  8. A cellular automaton implementation of a quantum battle of the sexes game with imperfect information

    NASA Astrophysics Data System (ADS)

    Alonso-Sanz, Ramón

    2015-10-01

    The dynamics of a spatial quantum formulation of the iterated battle of the sexes game with imperfect information is studied in this work. The game is played with variable entangling in a cellular automata manner, i.e. with local and synchronous interaction. The effect of spatial structure is assessed in fair and unfair scenarios.

  9. Possibility of direct measurement of thermoelastic stresses in imperfect crystals subjected to laser radiation

    SciTech Connect

    Prave, G.G.; Chudakov, V.S.; Yanusova, L.G.

    1983-09-01

    The authors discuss the possibility of direct optical polarization investigations of thermoelastic stresses when a laser acts on an imperfect crystal or other isotropic object possessing initial stresses. They propose an optimal method of investigating crystalline plates with surface orientations (100) and (111) with the aid of a photoelectric polariscope.

  10. The puzzling origin of the Martian Northern Lowlands.

    NASA Astrophysics Data System (ADS)

    Altieri, F.; Carrozzo, G.; Carli, C.; Geminale, A.; Bellucci, G.

    Surface studies of the northern lowlands of Mars have shown that this region has undergone a complex history including volcanism, sedimentary deposition and secondary modification by climate change. Despite these analyses, the origin and the evolution of this region are still debated. No clear and definitive evidences have been found so far to conclude whether these plains were formed by a giant impact, were once covered by an ocean or were filled by a large quantity of lavas. In the visible and infrared spectral range, the northern lowlands differ from southern terrains in the NIR negative slope while they exhibit VNIR spectra similar to the southern pyroxene-rich areas (Carrozzo et al., 2012). These observations, combined with both recent detection of mafic minerals at higher spatial resolution by CRISM (Salvatore et al., 2010) and recent results of Horgan and Bell (2012), supports that their mineralogy is linked to weathered basalts with a glassy component. In addition to this, the spectral similarity of Acidalia area with the northern circumpolar sand dunes, apart from the hydration features, suggests that the weathering processes that took place there could be related to past glacial activity, in agreement with superficial morphology showing glacial structures. Aim of this work is to combine the OMEGA mineralogical maps with morphological features (Tanaka et al., 2011) and investigate possible terrestrial analogues in order to give some constrains on the composition and origin of these puzzling Martian terrains.

  11. Hyperon puzzle of neutron stars with Skyrme force models

    NASA Astrophysics Data System (ADS)

    Lim, Yeunhwan; Hyun, Chang Ho; Kwak, Kyujin; Lee, Chang-Hwan

    2015-12-01

    We consider the so-called hyperon puzzle of neutron star (NS). We employ Skyrme force models for the description of in-medium nucleon-nucleon (NN), nucleon-Lambda hyperon (NΛ) and Lambda-Lambda (ΛΛ) interactions. A phenomenological finite-range force (FRF) for the ΛΛ interaction is considered as well. Equation of state (EoS) of NS matter is obtained in the framework of density functional theory, and Tolman-Oppenheimer-Volkoff (TOV) equations are solved to obtain the mass-radius relations of NSs. It has been generally known that the existence of hyperons in the NS matter is not well supported by the recent discovery of large-mass NSs (M ≃ 2M⊙) since hyperons make the EoS softer than the one without them. For the selected interaction models, NΛ interactions reduce the maximum mass of NS by about 30%, while ΛΛ interactions can give about 10% enhancement. Consequently, we find that some Skyrme force models predict the maximum mass of NS consistent with the observation of 2M⊙ NSs, and at the same time satisfy observationally constrained mass-radius relations.

  12. Is the proton radius puzzle evidence of extra dimensions?

    NASA Astrophysics Data System (ADS)

    Dahia, F.; Lemos, A. S.

    2016-08-01

    The proton charge radius inferred from muonic hydrogen spectroscopy is not compatible with the previous value given by CODATA-2010, which, on its turn, essentially relies on measurements of the electron-proton interaction. The proton's new size was extracted from the 2S-2P Lamb shift in the muonic hydrogen, which showed an energy excess of 0.3 meV in comparison to the theoretical prediction, evaluated with the CODATA radius. Higher-dimensional gravity is a candidate to explain this discrepancy, since the muon-proton gravitational interaction is stronger than the electron-proton interaction and, in the context of braneworld models, the gravitational potential can be hugely amplified in short distances when compared to the Newtonian potential. Motivated by these ideas, we study a muonic hydrogen confined in a thick brane. We show that the muon-proton gravitational interaction modified by extra dimensions can provide the additional separation of 0.3 meV between the 2S and 2P states. In this scenario, the gravitational energy depends on the higher-dimensional Planck mass and indirectly on the brane thickness. Studying the behavior of the gravitational energy with respect to the brane thickness in a realistic range, we find constraints for the fundamental Planck mass that solve the proton radius puzzle and are consistent with previous experimental bounds.

  13. Fanconi anemia proteins and their interacting partners: a molecular puzzle.

    PubMed

    Kaddar, Tagrid; Carreau, Madeleine

    2012-01-01

    In recent years, Fanconi anemia (FA) has been the subject of intense investigations, primarily in the DNA repair research field. Many discoveries have led to the notion of a canonical pathway, termed the FA pathway, where all FA proteins function sequentially in different protein complexes to repair DNA cross-link damages. Although a detailed architecture of this DNA cross-link repair pathway is emerging, the question of how a defective DNA cross-link repair process translates into the disease phenotype is unresolved. Other areas of research including oxidative metabolism, cell cycle progression, apoptosis, and transcriptional regulation have been studied in the context of FA, and some of these areas were investigated before the fervent enthusiasm in the DNA repair field. These other molecular mechanisms may also play an important role in the pathogenesis of this disease. In addition, several FA-interacting proteins have been identified with roles in these "other" nonrepair molecular functions. Thus, the goal of this paper is to revisit old ideas and to discuss protein-protein interactions related to other FA-related molecular functions to try to give the reader a wider perspective of the FA molecular puzzle. PMID:22737580

  14. Hyperon Puzzle: Hints from Quantum Monte Carlo Calculations

    NASA Astrophysics Data System (ADS)

    Lonardoni, Diego; Lovato, Alessandro; Gandolfi, Stefano; Pederiva, Francesco

    2015-03-01

    The onset of hyperons in the core of neutron stars and the consequent softening of the equation of state have been questioned for a long time. Controversial theoretical predictions and recent astrophysical observations of neutron stars are the grounds for the so-called hyperon puzzle. We calculate the equation of state and the neutron star mass-radius relation of an infinite systems of neutrons and Λ particles by using the auxiliary field diffusion Monte Carlo algorithm. We find that the three-body hyperon-nucleon interaction plays a fundamental role in the softening of the equation of state and for the consequent reduction of the predicted maximum mass. We have considered two different models of three-body force that successfully describe the binding energy of medium mass hypernuclei. Our results indicate that they give dramatically different results on the maximum mass of neutron stars, not necessarily incompatible with the recent observation of very massive neutron stars. We conclude that stronger constraints on the hyperon-neutron force are necessary in order to properly assess the role of hyperons in neutron stars.

  15. Hyperon puzzle: hints from quantum Monte Carlo calculations.

    PubMed

    Lonardoni, Diego; Lovato, Alessandro; Gandolfi, Stefano; Pederiva, Francesco

    2015-03-01

    The onset of hyperons in the core of neutron stars and the consequent softening of the equation of state have been questioned for a long time. Controversial theoretical predictions and recent astrophysical observations of neutron stars are the grounds for the so-called hyperon puzzle. We calculate the equation of state and the neutron star mass-radius relation of an infinite systems of neutrons and Λ particles by using the auxiliary field diffusion Monte Carlo algorithm. We find that the three-body hyperon-nucleon interaction plays a fundamental role in the softening of the equation of state and for the consequent reduction of the predicted maximum mass. We have considered two different models of three-body force that successfully describe the binding energy of medium mass hypernuclei. Our results indicate that they give dramatically different results on the maximum mass of neutron stars, not necessarily incompatible with the recent observation of very massive neutron stars. We conclude that stronger constraints on the hyperon-neutron force are necessary in order to properly assess the role of hyperons in neutron stars. PMID:25793808

  16. The Puzzling Case of Hyperexcitability in Amyotrophic Lateral Sclerosis

    PubMed Central

    Bae, Jong Seok; Simon, Neil G.; Menon, Parvathi; Vucic, Steve

    2013-01-01

    The development of hyperexcitability in amyotrophic lateral sclerosis (ALS) is a well-known phenomenon. Despite controversy as to the underlying mechanisms, cortical hyperexcitability appears to be closely related to the interplay between excitatory corticomotoneurons and inhibitory interneurons. Hyperexcitability is not a static phenomenon but rather shows a pattern of progression in a spatiotemporal aspect. Cortical hyperexcitability may serve as a trigger to the development of anterior horn cell degeneration through a 'dying forward' process. Hyperexcitability appears to develop during the early disease stages and gradually disappears in the advanced stages of the disease, linked to the destruction of corticomotorneuronal pathways. As such, a more precise interpretation of these unique processes may provide new insight regarding the pathophysiology of ALS and its clinical features. Recently developed technologies such as threshold tracking transcranial magnetic stimulation and automated nerve excitability tests have provided some clues about underlying pathophysiological processes linked to hyperexcitability. Additionally, these novel techniques have enabled clinicians to use the specific finding of hyperexcitability as a useful diagnostic biomarker, enabling clarification of various ALS-mimic syndromes, and the prediction of disease development in pre-symptomatic carriers of familial ALS. In terms of nerve excitability tests for peripheral nerves, an increase in persistent Na+ conductances has been identified as a major determinant of peripheral hyperexcitability in ALS, inversely correlated with the survival in ALS. As such, the present Review will focus primarily on the puzzling theory of hyperexcitability in ALS and summarize clinical and pathophysiological implications for current and future ALS research. PMID:23626643

  17. Improving Prediction Skill of Imperfect Turbulent Models Through Statistical Response and Information Theory

    NASA Astrophysics Data System (ADS)

    Majda, Andrew J.; Qi, Di

    2016-02-01

    Turbulent dynamical systems with a large phase space and a high degree of instabilities are ubiquitous in climate science and engineering applications. Statistical uncertainty quantification (UQ) to the response to the change in forcing or uncertain initial data in such complex turbulent systems requires the use of imperfect models due to the lack of both physical understanding and the overwhelming computational demands of Monte Carlo simulation with a large-dimensional phase space. Thus, the systematic development of reduced low-order imperfect statistical models for UQ in turbulent dynamical systems is a grand challenge. This paper applies a recent mathematical strategy for calibrating imperfect models in a training phase and accurately predicting the response by combining information theory and linear statistical response theory in a systematic fashion. A systematic hierarchy of simple statistical imperfect closure schemes for UQ for these problems is designed and tested which are built through new local and global statistical energy conservation principles combined with statistical equilibrium fidelity. The forty mode Lorenz 96 (L-96) model which mimics forced baroclinic turbulence is utilized as a test bed for the calibration and predicting phases for the hierarchy of computationally cheap imperfect closure models both in the full phase space and in a reduced three-dimensional subspace containing the most energetic modes. In all of phase spaces, the nonlinear response of the true model is captured accurately for the mean and variance by the systematic closure model, while alternative methods based on the fluctuation-dissipation theorem alone are much less accurate. For reduced-order model for UQ in the three-dimensional subspace for L-96, the systematic low-order imperfect closure models coupled with the training strategy provide the highest predictive skill over other existing methods for general forced response yet have simple design principles based on a

  18. Effect of a puzzle on the process of students' learning about cardiac physiology.

    PubMed

    Cardozo, Lais Tono; Miranda, Aline Soares; Moura, Maria José Costa Sampaio; Marcondes, Fernanda Klein

    2016-09-01

    The aim of the present study was to evaluate the effects of using a puzzle to learn about cardiac physiology. Students were divided into control and game groups. In class 1, the control group had a 2-h theoretical class about cardiac physiology, including a detailed description of the phases of the cardiac cycle, whereas the game group had a 50-min theoretical class without the description of the cardiac cycle. In class 2, the control group did an assessment exercise before an activity with the cardiac puzzle and the game group answered questions after the above-mentioned activity. While solving the puzzle, the students had to describe the cardiac cycle by relating the concepts of heart morphology and physiology. To evaluate short-term learning, the number of wrong answers and grades in the assessment exercise were compared between the control and game groups. To evaluate medium-term learning, we compared the grades obtained by students of the control and game groups in questions about cardiac physiology that formed part of the academic exam. In the assessment exercise, the game group presented a lower number of errors and higher score compared with the control group. In the academic exam, applied after both groups had used the puzzle, there was no difference in the scores obtained by the control and game groups in questions about cardiac physiology. These results showed a positive effect of the puzzle on students' learning about cardiac physiology compared with those not using the puzzle. PMID:27516391

  19. Investigation on the Geometric Imperfections driven Local Buckling Onset in Composite Conical Shells

    NASA Astrophysics Data System (ADS)

    Di Pasqua, Maria Francesca; Khakimova, Regina; Castro, Saullo G. P.; Arbelo, Mariano A.; Riccio, Aniello; Raimondo, Antonio; Degenhardt, Richard

    2016-04-01

    Buckling is a critical failure phenomenon for structures, and represents a threat for thin shells subjected to compressive forces. The global buckling load, for a conical structure, depends on the geometry and material properties of the shell, on the stacking sequence, on the type of applied load and on the initial geometric imperfections. Geometric imperfections, occurring inevitably during manufacturing and assembly of thin-walled composite structures, produce a reduction in the carrying load capability with respect to the design value. This is the reason why investigating these defects is of major concern in order to avoid over-conservative design structures. In this paper, the buckling behavior a conical structure with 45° semi-vertical angle is numerically investigated. The initial imperfections are taken into account by using different strategies. At first, the Single Perturbation Load Approach (SPLA), which accounts for defects in the form of a lateral load, normal to the surface, has been adopted. Then, the actual measured defects have been applied to the structure by using the Real Measured Mid-Surface Imperfections (MSI) approach. Investigations on cylindrical shells using the first strategy have already shown the occurrence of a particular phenomenon called "local snap-through", which represents a preliminary loss of stiffness. In order to better understand this phenomenon for conical shells, both the aforementioned techniques have been used to provide an exhaustive overview of the imperfections sensitiveness in conical composite shells. This study is related to part of the work performed in the frame of the European Union (EU) project DESICOS.

  20. Investigation on the Geometric Imperfections driven Local Buckling Onset in Composite Conical Shells

    NASA Astrophysics Data System (ADS)

    Di Pasqua, Maria Francesca; Khakimova, Regina; Castro, Saullo G. P.; Arbelo, Mariano A.; Riccio, Aniello; Raimondo, Antonio; Degenhardt, Richard

    2016-08-01

    Buckling is a critical failure phenomenon for structures, and represents a threat for thin shells subjected to compressive forces. The global buckling load, for a conical structure, depends on the geometry and material properties of the shell, on the stacking sequence, on the type of applied load and on the initial geometric imperfections. Geometric imperfections, occurring inevitably during manufacturing and assembly of thin-walled composite structures, produce a reduction in the carrying load capability with respect to the design value. This is the reason why investigating these defects is of major concern in order to avoid over-conservative design structures. In this paper, the buckling behavior a conical structure with 45° semi-vertical angle is numerically investigated. The initial imperfections are taken into account by using different strategies. At first, the Single Perturbation Load Approach (SPLA), which accounts for defects in the form of a lateral load, normal to the surface, has been adopted. Then, the actual measured defects have been applied to the structure by using the Real Measured Mid-Surface Imperfections (MSI) approach. Investigations on cylindrical shells using the first strategy have already shown the occurrence of a particular phenomenon called "local snap-through", which represents a preliminary loss of stiffness. In order to better understand this phenomenon for conical shells, both the aforementioned techniques have been used to provide an exhaustive overview of the imperfections sensitiveness in conical composite shells. This study is related to part of the work performed in the frame of the European Union (EU) project DESICOS.

  1. ON THE PUZZLE OF SPACE WEATHERING ALTERATION OF BASALTIC ASTEROIDS

    SciTech Connect

    Marchi, S.; Lazzarin, M.; Magrin, S.; De Sanctis, M. C. E-mail: monica.lazzarin@unipd.i E-mail: mariacristina.desanctis@iasf-roma.inaf.i

    2010-10-01

    The majority of basaltic asteroids are found in the inner main belt, although a few have also been observed in the outer main belt and near-Earth space. These asteroids-referred to as V-types-have surface compositions that resemble that of the 530 km sized asteroid Vesta. Besides the compositional similarity, dynamical evidence also links many V-type asteroids to Vesta. Moreover, Vesta is one of the few asteroids to have been identified as source of specific classes of meteorites, the howardite, eucrite, and diogenite achondrites (HEDs). Despite the general consensus on the outlined scenario, several questions remain unresolved. In particular, it is not clear if the observed spectral diversity among Vesta, V-types, and HEDs is due to space weathering, as is thought to be the case for S-type asteroids. In this Letter, SDSS photometry is used to address the question of whether the spectral diversity among candidate V-types and HEDs can be explained by space weathering. We show that visible spectral slopes of V-types are systematically redder with respect to HEDs, in a similar way to what is found for ordinary chondrite meteorites and S-types. On the assumption that space weathering is responsible for the slope mismatch, we estimated an upper limit for the reddening timescale of about 0.5 Ga. Nevertheless, the observed slope mismatch between HEDs and V-types poses several puzzles to understanding its origin. The implication of our findings is also discussed in light of the Dawn mission to Vesta.

  2. The puzzle of immune phenotypes of childhood asthma.

    PubMed

    Landgraf-Rauf, Katja; Anselm, Bettina; Schaub, Bianca

    2016-12-01

    new immunological molecules, the complex puzzle of childhood asthma is still far from being completed. Addressing the current challenges of distinct clinical asthma and wheeze phenotypes, including their stability and underlying endotypes, involves addressing the interplay of innate and adaptive immune regulatory mechanisms in large, interdisciplinary cohorts. PMID:27468754

  3. Hyperon puzzle, hadron-quark crossover and massive neutron stars

    NASA Astrophysics Data System (ADS)

    Masuda, Kota; Hatsuda, Tetsuo; Takatsuka, Tatsuyuki

    2016-03-01

    Bulk properties of cold and hot neutron stars are studied on the basis of the hadron-quark crossover picture where a smooth transition from the hadronic phase to the quark phase takes place at finite baryon density. By using a phenomenological equation of state (EOS) "CRover", which interpolates the two phases at around 3 times the nuclear matter density (ρ0, it is found that the cold NSs with the gravitational mass larger than 2M_{odot} can be sustained. This is in sharp contrast to the case of the first-order hadron-quark transition. The radii of the cold NSs with the CRover EOS are in the narrow range (12.5 ± 0.5) km which is insensitive to the NS masses. Due to the stiffening of the EOS induced by the hadron-quark crossover, the central density of the NSs is at most 4 ρ0 and the hyperon-mixing barely occurs inside the NS core. This constitutes a solution of the long-standing hyperon puzzle. The effect of color superconductivity (CSC) on the NS structures is also examined with the hadron-quark crossover. For the typical strength of the diquark attraction, a slight softening of the EOS due to two-flavor CSC (2SC) takes place and the maximum mass is reduced by about 0.2M_{odot}. The CRover EOS is generalized to the supernova matter at finite temperature to describe the hot NSs at birth. The hadron-quark crossover is found to decrease the central temperature of the hot NSs under isentropic condition. The gravitational energy release and the spin-up rate during the contraction from the hot NS to the cold NS are also estimated.

  4. Characterising the effect of global and local geometric imperfections on the numerical performance of a brace member

    NASA Astrophysics Data System (ADS)

    Hassan, M. S.; Goggins, J.; Salawdeh, S.

    2015-07-01

    A numerical imperfection study is carried out on a hot rolled tubular brace member under displacement controlled amplitudes. An appropriate range of global and local imperfections is used in the finite element analyses to evaluate the initial-post buckling compressive strength, lateral storey drift, energy dissipation and mid-length lateral deformation of the brace member. The purpose of this study is to assess the impact of the geometrical imperfection on the numerical performance, and to determine an amplitude range that can be used unequivocally for numerical modelling of brace members. It is shown that the amplitude of global imperfections has an effect on the initial response, whereas the amplitude of local imperfections has influence on the resistance capacity of the brace member at higher ductility level. Based on the results, a refined range of amplitude of global and local imperfections is proposed. This range is found to have a good agreement with design standards. In addition, an already established equation to find lateral deformation is compared to results from the analyses and found that the equation with some modification can be used accurately in design. In this paper, a modification factor is proposed in the equation to find the lateral deformation to account for the imperfection amplitude in the numerical analyses of brace members.

  5. On vibrational imperfection sensitivity of Augusti's model structure in the vicinity of a non-linear static state

    NASA Technical Reports Server (NTRS)

    Elishakoff, Isaac; Marcus, S.; Starnes, J. H., JR.

    1998-01-01

    In this paper we present a closed-form solution for vibrational imperfection sensitivity the effect of small imperfections on the vibrational frequencies of perturbed motion around the static equilibrium state of Augusti's model Structure (a rigid link, pinned at one end to a rigid foundation and supported at the other by a linear extensional spring that retains its horizontality, as the system deflects). We also treat a modified version of that model with attendant slightly different dynamics. It is demonstrated that the vibrational frequencies decreases as the initial imperfections increase.

  6. Unequal Knowledge.

    ERIC Educational Resources Information Center

    Tilly, Charles

    2003-01-01

    Discusses how the persistence of knowledge inequalities influences higher education. Explores how the control of and access to knowledge affects human well being (i.e., control over production of knowledge, control over its distribution, and access to knowledge by people whose well being it will or could affect). (EV)

  7. Knowledge Management.

    ERIC Educational Resources Information Center

    1999

    The first of the four papers in this symposium, "Knowledge Management and Knowledge Dissemination" (Wim J. Nijhof), presents two case studies exploring the strategies companies use in sharing and disseminating knowledge and expertise among employees. "A Theory of Knowledge Management" (Richard J. Torraco), develops a conceptual framework for…

  8. A (15)N CPMG relaxation dispersion experiment more resistant to resonance offset and pulse imperfection.

    PubMed

    Jiang, Bin; Yu, Binhan; Zhang, Xu; Liu, Maili; Yang, Daiwen

    2015-08-01

    Carr-Purcell-Meiboom-Gill (CPMG) relaxation dispersion is a powerful NMR method to study protein dynamics on the microsecond-millisecond time scale. J-coupling, resonance offset, radio frequency field inhomogeneity, and pulse imperfection often introduce systematic errors into the measured transverse relaxation rates. Here we proposed a modified continuous wave decoupling CPMG experiment, which is more unaffected by resonance offset and pulse imperfection. We found that it is unnecessary to match the decoupling field strength with the delay between CPMG refocusing pulses, provided that decoupling field is strong enough. The performance of the scheme proposed here was shown by simulations and further demonstrated experimentally on a fatty acid binding protein. PMID:26037134

  9. Broadband shock-associated noise of moderately imperfectly expanded supersonic jets

    NASA Technical Reports Server (NTRS)

    Tam, C. K. W.

    1990-01-01

    Recently a stochastic model theory of broadband shock-associated noise from supersonic jets was developed. The theory is capable of predicting the near and far field noise spectra of slightly imperfectly expanded jets. In this paper, the noise prediction formulas are extended to the moderately imperfectly expanded Mach number range. It is found that the shock noise intensity depends only on the amplitude of the quasi-periodic shock cell structure and not on the strong first shock. This makes it possible to extend the noise prediction formulas by simply modifying the shock cell strength in the original formulas. Here this step is implemented semiempirically, and a set of shock noise prediction formulas are developed.

  10. Three-dimensional imperfections in a model vertical Bridgman growth system for cadmium zinc telluride

    NASA Astrophysics Data System (ADS)

    Yeckel, Andrew; Compère, Geoffrey; Pandy, Arun; Derby, Jeffrey J.

    2004-03-01

    Three-dimensional, quasi-steady-state modeling of heat transfer, flow, and segregation are carried out with a self-consistent, parallel, finite element model to analyze the effects of imperfections on a model system for the vertical Bridgman growth of cadmium zinc telluride. Even small amounts of ampoule tilting (defined as the offset between the ampoule axis from the direction of gravity) produce large asymmetries in the flow and solute segregation. However, the application of ampoule rotation, at rates far smaller than considered in prior studies, acts to restore axisymmetric segregation behavior. Thermal imperfections caused by ampoule offset in the furnace bore and ampoule distortion are also shown to yield significant three-dimensional flows and segregation asymmetry. Local heating is shown to strongly affect solute mixing and may be effective in active strategies for segregation control.

  11. Imperfection and radiation damage in protein crystals studied with coherent radiation

    PubMed Central

    Nave, Colin; Sutton, Geoff; Evans, Gwyndaf; Owen, Robin; Rau, Christoph; Robinson, Ian; Stuart, David Ian

    2016-01-01

    Fringes and speckles occur within diffraction spots when a crystal is illuminated with coherent radiation during X-ray diffraction. The additional information in these features provides insight into the imperfections in the crystal at the sub-micrometre scale. In addition, these features can provide more accurate intensity measurements (e.g. by model-based profile fitting), detwinning (by distinguishing the various components), phasing (by exploiting sampling of the molecular transform) and refinement (by distinguishing regions with different unit-cell parameters). In order to exploit these potential benefits, the features due to coherent diffraction have to be recorded and any change due to radiation damage properly modelled. Initial results from recording coherent diffraction at cryotemperatures from polyhedrin crystals of approximately 2 µm in size are described. These measurements allowed information about the type of crystal imperfections to be obtained at the sub-micrometre level, together with the changes due to radiation damage. PMID:26698068

  12. Rotordynamic effects driven by fluid forces from a geometrically imperfect labyrinth

    NASA Astrophysics Data System (ADS)

    Williston, William C., Jr.

    1993-12-01

    The forces on a rotor due to asymmetric pressure distributions resulting from a single gland non-circular labyrinth seal in a circular outer casing are analyzed for the purpose of understanding the possible causes of synchronous vibration due to seal intolerance. A lumped parameter model is developed for flow in the azimuthal direction inside the seal gland. The sealing knife imperfections causing the non-circularity may be due to manufacturing defects or in service ware. The resulting continuity and momentum equations are solved using a regular linear perturbation technique. Results from this model indicate under what conditions seal imperfections can generate forces of the same order of magnitude as rotor mass unbalance.

  13. Vertical Dynamic Interaction Between Train and Track Influence of Wheel and Track Imperfections

    NASA Astrophysics Data System (ADS)

    Nielsen, J. C. O.; Igeland, A.

    1995-11-01

    The vertical dynamic behaviour is investigated for a railway bogie moving on a rail which is discretely supported, via railpads, by sleepers resting on an elastic foundation. The transient interaction problem is numerically solved by use of an extended state-spacer vector approach in conjunction with a complex modal superposition for the track. Application examples are given in which the influences of three types of practically important imperfections in the compound vehicle/track system are investigated. The first is a sinusoidal corrugation of the railhead and the second a skid flat on the wheel tread (a wheelflat). The third imperfection is a case where a single sleeper has lost its support due to erosion of the ballast. Physical explanations of the calculated interaction behaviour are given.

  14. EPQ model with learning consideration, imperfect production and partial backlogging in fuzzy random environment

    NASA Astrophysics Data System (ADS)

    Shankar Kumar, Ravi; Goswami, A.

    2015-06-01

    The article scrutinises the learning effect of the unit production time on optimal lot size for the uncertain and imprecise imperfect production process, wherein shortages are permissible and partially backlogged. Contextually, we contemplate the fuzzy chance of production process shifting from an 'in-control' state to an 'out-of-control' state and re-work facility of imperfect quality of produced items. The elapsed time until the process shifts is considered as a fuzzy random variable, and consequently, fuzzy random total cost per unit time is derived. Fuzzy expectation and signed distance method are used to transform the fuzzy random cost function into an equivalent crisp function. The results are illustrated with the help of numerical example. Finally, sensitivity analysis of the optimal solution with respect to major parameters is carried out.

  15. How might Model-based Probabilities Extracted from Imperfect Models Guide Rational Decisions: The Case for non-probabilistic odds

    NASA Astrophysics Data System (ADS)

    Smith, Leonard A.

    2010-05-01

    whether or not probabilities based on imperfect models can be expected to yield probabilistic odds which are sustainable. Evidence is provided that suggest this is not the case. Even with very good models (good in an Root-Mean-Square sense), the risk of ruin of probabilistic odds is significantly higher than might be expected. Methods for constructing model-based non-probabilistic odds which are sustainable are discussed. The aim here is to be relevant to real world decision support, and so unrealistic assumptions of equal knowledge, equal compute power, or equal access to information are to be avoided. Finally, the use of non-probabilistic odds as a method for communicating deep uncertainty (uncertainty in a probability forecast itself) is discussed in the context of other methods, such as stating one's subjective probability that the models will prove inadequate in each particular instance (that is, the Probability of a "Big Surprise").

  16. Nonlinear vibrations and imperfection sensitivity of a cylindrical shell containing axial fluid flow

    NASA Astrophysics Data System (ADS)

    del Prado, Z.; Gonçalves, P. B.; Païdoussis, M. P.

    2009-10-01

    The high imperfection sensitivity of cylindrical shells under static compressive axial loads is a well-known phenomenon in structural stability. On the other hand, less is known of the influence of imperfections on the nonlinear vibrations of these shells under harmonic axial loads. The aim of this work is to study the simultaneous influence of geometric imperfections and an axial fluid flow on the nonlinear vibrations and instabilities of simply supported circular cylindrical shells under axial load. The fluid is assumed to be non-viscous and incompressible and the flow to be isentropic and irrotational. The behavior of the thin-walled shell is modeled by Donnell's nonlinear shallow-shell equations. It is subjected to a static uniform compressive axial pre-load plus a harmonic axial load. A low-dimensional modal expansion, which satisfies the relevant boundary and continuity conditions, and takes into account all relevant nonlinear modal interactions observed in the past in the nonlinear vibrations of cylindrical shells with and without flow is used together with the Galerkin method to derive a set of eight coupled nonlinear ordinary differential equations of motion which are, in turn, solved by the Runge-Kutta method. The shell is considered to be initially at rest, in a position corresponding to a pre-buckling configuration. Then, a harmonic excitation is applied and conditions for parametric instability and dynamic snap-through are sought. The results clarify the marked influence of geometric imperfections and fluid flow on the dynamic stability boundaries, bifurcations and basins of attraction.

  17. Upper bound on the secret key rate distillable from effective quantum correlations with imperfect detectors

    SciTech Connect

    Moroder, Tobias; Curty, Marcos; Luetkenhaus, Norbert

    2006-01-15

    We provide a simple method to obtain an upper bound on the secret key rate that is particularly suited to analyze practical realizations of quantum key distribution protocols with imperfect devices. We consider the so-called trusted device scenario where Eve cannot modify the actual detection devices employed by Alice and Bob. The upper bound obtained is based on the available measurements results, but it includes the effect of the noise and losses present in the detectors of the legitimate users.

  18. Effects of ultraviolet radiation on lattice imperfections in pyrolytic boron nitride.

    NASA Technical Reports Server (NTRS)

    Buckley, J. D.; Cooley, J. A.

    1971-01-01

    Pyrolitic boron nitride was exposed to 310 equivalent sun hours of ultraviolet radiation in a space environment simulator with the objective to evaluate its applicability as a pigment for a thermal control coating and to identify radiation damage using X-ray diffraction techniques. Lattice parameter comparisons show a definite increase in lattice imperfections in the crystal structure resulting from the ultraviolet irradiation. This sensitivity to radiation damage makes pyrolitic boron nitride unsuitable as a pigment for thermal control coating.

  19. Sensitivity of buckling loads of anisotropic shells of revolution to geometric imperfections and design changes

    NASA Technical Reports Server (NTRS)

    Cohen, Gerald A.; Haftka, Raphael T.

    1989-01-01

    Buckling load sensitivity calculations in the shell-of-revolution program FASOR are discussed. This development is based on Koiter's initial postbuckling theory, which has been generalized to include the effect of stiffness changes, as well as geometric imperfections. The implementation in FASOR is valid for anisotropic, as well as orthotropic, shells. Examples are presented for cylindrical panels under axial compression, complete cylindrical shells in torsion, and antisymmetric angle-ply cylindrical panels under edge shear.

  20. Nonlinear size-dependent dynamics of an imperfect shear deformable microplate

    NASA Astrophysics Data System (ADS)

    Farokhi, Hamed; Ghayesh, Mergen H.

    2016-01-01

    The nonlinear size-dependent dynamics of a geometrically imperfect shear deformable microplate is investigated based on the modified couple stress theory. An initial imperfection in the out-of-plane direction is taken into account. The third-order shear deformation theory is employed to model the system by retaining in-plane displacements and inertia. The governing equations of motion of the system are obtained employing an energy method through use of the Lagrange equations, which upon employing an assumed-mode technique, yields a set of second-order nonlinear ordinary differential equations with coupled terms. A high-dimensional discretised system is considered and made double-dimensional via a change of variables in order to obtain a set of first-order nonlinear ordinary differential equations. The resulting equations are solved using a direct time-integration technique, resulting in time-dependent generalised coordinates for the in-plane and out-of-plane displacements and two rotations. From these generalised coordinates, phase-plane portraits and fast Fourier transforms (FFTs) are also obtained. Moreover, the frequency-response and force-response curves of the system are obtained using a continuation technique; stability analysis is conducted via the Floquet theory. The effect of the initial imperfection as well as the length-scale parameter on the system response is also examined.

  1. Economic production quantity (EPQ) models under an imperfect production process with shortages backordered

    NASA Astrophysics Data System (ADS)

    Hsu, Lie-Fern; Hsu, Jia-Tzer

    2016-03-01

    In this paper, we develop economic production quantity (EPQ) models to determine the optimal production lot size and backorder quantity for a manufacturer under an imperfect production process. The imperfect production process is characterised by the fraction of defective items at the time of production γ. The paper considers different cases of the EPQ model depending on (1) whether γ is known with certainty or is a random variable, and (2) whether imperfect items are drawn from inventory (a) as they are detected, (b) at the end of each production period or (c) at the end of each production cycle. Straightforward convexity results are shown and closed-form solutions are provided for the optimal order and backorder quantities for each of the cases we considered. We provide two numerical examples: one in which the defective probability follows a uniform distribution and the second which we assume follows a beta distribution, to illustrate the effects of yield variability and timing of the withdrawal of defectives on the optimal solutions. We obtain similar results for both numerical examples, which show that both the yield variability and the withdrawal timing are not critical factors.

  2. Buckling Analysis of a Honeycomb-Core Composite Cylinder with Initial Geometric Imperfections

    NASA Technical Reports Server (NTRS)

    Cha, Gene; Schultz, Marc R.

    2013-01-01

    Thin-walled cylindrical shell structures often have buckling as the critical failure mode, and the buckling of such structures can be very sensitive to small geometric imperfections. The buckling analyses of an 8-ft-diameter, 10-ft-long honeycomb-core composite cylinder loaded in pure axial compression is discussed in this document. Two loading configurations are considered configuration 1 uses simple end conditions, and configuration 2 includes additional structure that may more closely approximate experimental loading conditions. Linear eigenvalue buckling analyses and nonlinear analyses with and without initial geometric imperfections were performed on both configurations. The initial imperfections were introduced in the shell by applying a radial load at the midlength of the cylinder to form a single inward dimple. The critical bifurcation buckling loads are predicted to be 924,190 lb and 924,020 lb for configurations 1 and 2, respectively. Nonlinear critical buckling loads of 918,750 lb and 954,900 lb were predicted for geometrically perfect configurations 1 and 2, respectively. Lower-bound critical buckling loads for configurations 1 and 2 with radial perturbations were found to be 33% and 36% lower, respectively, than the unperturbed critical loads. The inclusion of the load introduction cylinders in configuration 2 increased the maximum bending-boundary-layer rotation up to 11%.

  3. The relationship between mimetic imperfection and phenotypic variation in insect colour patterns.

    PubMed Central

    Holloway, Graham; Gilbert, Francis; Brandt, Amoret

    2002-01-01

    Many hoverflies (Syrphidae) mimic wasps or bees through colour or behavioural adaptations. The relationship between phenotypic variation in colour pattern and mimetic perfection (as determined by pigeons) was investigated in three species of Müllerian mimics (Vespula spp.) and 10 Batesian hoverfly mimics, plus two non-mimetic species of flies. Four predictions were tested: (i) Batesian mimics might be imperfect because they are in the process of evolving towards perfection, hence there should be a positive relationship between variation and imperfection; (ii) some Batesian mimics are imperfect because they do not have the appropriate genetic variation to improve and have evolved to be as good as possible, hence there should be no differences between species, all displaying a low level of variation; (iii) very common hoverflies should show the highest levels of variation because they outnumber their models, resulting in high predation and a breakdown in the mimetic relationship; and (iv) social wasps (Vespula) have such a powerful defence that anything resembling a wasp, both Müllerian and perfect Batesian mimics, would be avoided, resulting in relaxed selection and high variance. Poor mimics may still evolve to resemble wasps as well as possible and display lower levels of variation. The data only provided support for the fourth prediction. The Müllerian mimics, one of the most perfect Batesian mimics, and the non-mimetic flies displayed much higher levels of variation than the other species of Batesian mimics. PMID:11886630

  4. Lamb wave dispersion in a PZT/metal/PZT sandwich plate with imperfect interface

    NASA Astrophysics Data System (ADS)

    Kurt, Ilkay; Akbarov, Surkay D.; Sezer, Semih

    2016-07-01

    The Lamb wave dispersion in a PZT/Metal/PZT sandwich plate is investigated by employing the exact linear equations of electro-elastic waves in piezoelectric materials within the scope of the plane-strain state. It is assumed that at the interfaces between the piezoelectric face layers and metal core layer, shear-spring and normal-spring type imperfect conditions are satisfied. The degree of this imperfectness is estimated through the corresponding shear-spring and normal-spring type parameters which appear in the contact condition characterizing the transverse and normal displacements' discontinuity. The corresponding dispersion equation is derived, and as a result of the numerical solution to this equation, the dispersion curves are constructed for the first and second lowest modes in the cases where the material of the face layers is PZT and the material of the middle layer is Steel (St). Consequently, for the PZT/St/PZT sandwich plate, the study of the influence of the problem parameters such as the piezoelectric and dielectric constants, layer thickness ratios, non-dimensional shear-spring, and normal-spring type parameters, is carried out. In particular, it is established that the imperfectness of the contact between the layers of the plate causes a decrease in the values of the wave propagation velocity.

  5. Current Knowledge on Pancreatic Cancer

    PubMed Central

    Iovanna, Juan; Mallmann, Maria Cecilia; Gonçalves, Anthony; Turrini, Olivier; Dagorn, Jean-Charles

    2012-01-01

    Pancreatic cancer is the fourth leading cause of cancer death with a median survival of 6 months and a dismal 5-year survival rate of 3–5%. The development and progression of pancreatic cancer are caused by the activation of oncogenes, the inactivation of tumor suppressor genes, and the deregulation of many signaling pathways. Therefore, the strategies targeting these molecules as well as their downstream signaling could be promising for the prevention and treatment of pancreatic cancer. However, although targeted therapies for pancreatic cancer have yielded encouraging results in vitro and in animal models, these findings have not been translated into improved outcomes in clinical trials. This failure is due to an incomplete understanding of the biology of pancreatic cancer and to the selection of poorly efficient or imperfectly targeted agents. In this review, we will critically present the current knowledge regarding the molecular, biochemical, clinical, and therapeutic aspects of pancreatic cancer. PMID:22655256

  6. The Effects of Geometric and Loading Imperfections on the Response and Lower-Bound Buckling Load of a Compression-Loaded Cylindrical Shell

    NASA Technical Reports Server (NTRS)

    Kriegesmann, Benedikt; Hilburger, Mark W.; Rolfes, Raimund

    2012-01-01

    Results from a numerical study of the buckling response of a thin-walled compressionloaded isotropic circular cylindrical shell with initial geometric and loading imperfections are used to determine a lower bound buckling load estimate suitable for preliminary design. The lower bound prediction techniques presented herein include an imperfection caused by a lateral perturbation load, an imperfection in the shape of a single stress-free dimple (similar to the lateral pertubation imperfection), and a distributed load imperfection that induces a nonuniform load in the shell. The ABAQUS finite element code is used for the analyses. Responses of the cylinders for selected imperfection amplitudes and imperfection types are considered, and the effect of each imperfection is compared to the response of a geometrically perfect cylinder. The results indicate that compression-loaded shells subjected to a lateral perturbation load or a single dimple imperfection, and a nonuniform load imperfection, exhibit similar buckling behavior and lower bound trends and the predicted lower bounds are much less conservative than the corresponding design recommendation NASA SP-8007 for the design of buckling-critical shells. In addition, the lateral perturbation technique and the distributed load imperfection produce response characteristics that are physically meaningful and can be validated via laboratory testing.

  7. Puzzle Imaging: Using Large-Scale Dimensionality Reduction Algorithms for Localization

    PubMed Central

    Glaser, Joshua I.; Zamft, Bradley M.; Church, George M.; Kording, Konrad P.

    2015-01-01

    Current high-resolution imaging techniques require an intact sample that preserves spatial relationships. We here present a novel approach, “puzzle imaging,” that allows imaging a spatially scrambled sample. This technique takes many spatially disordered samples, and then pieces them back together using local properties embedded within the sample. We show that puzzle imaging can efficiently produce high-resolution images using dimensionality reduction algorithms. We demonstrate the theoretical capabilities of puzzle imaging in three biological scenarios, showing that (1) relatively precise 3-dimensional brain imaging is possible; (2) the physical structure of a neural network can often be recovered based only on the neural connectivity matrix; and (3) a chemical map could be reproduced using bacteria with chemosensitive DNA and conjugative transfer. The ability to reconstruct scrambled images promises to enable imaging based on DNA sequencing of homogenized tissue samples. PMID:26192446

  8. The role of inhibitory control in children's cooperative behaviors during a structured puzzle task.

    PubMed

    Giannotta, Fabrizia; Burk, William J; Ciairano, Silvia

    2011-11-01

    This study examined the role of inhibitory control (measured by Stroop interference) in children's cooperative behaviors during a structured puzzle task. The sample consisted of 250 8-, 10-, and 12-year-olds (117 girls and 133 boys) attending classrooms in three primary schools in Northern Italy. Children individually completed an elaborated Stroop task, were paired with classmates into 125 dyads, and were observed during a 10-min puzzle task. Results confirmed that interaction partners exhibited similar levels of cooperative behaviors, and the cooperative behaviors of children predicted changes in the cooperative behaviors of their partners throughout the puzzle task. Cooperative behaviors of each interaction partner were predicted by the child's own inhibitory control as well as the inhibitory control of the partner. Findings are discussed within a developmental contextual framework. PMID:21645907

  9. Using the Tower of Hanoi puzzle to infuse your mathematics classroom with computer science concepts

    NASA Astrophysics Data System (ADS)

    Marzocchi, Alison S.

    2016-07-01

    This article suggests that logic puzzles, such as the well-known Tower of Hanoi puzzle, can be used to introduce computer science concepts to mathematics students of all ages. Mathematics teachers introduce their students to computer science concepts that are enacted spontaneously and subconsciously throughout the solution to the Tower of Hanoi puzzle. These concepts include, but are not limited to, conditionals, iteration, and recursion. Lessons, such as the one proposed in this article, are easily implementable in mathematics classrooms and extracurricular programmes as they are good candidates for 'drop in' lessons that do not need to fit into any particular place in the typical curriculum sequence. As an example for readers, the author describes how she used the puzzle in her own Number Sense and Logic course during the federally funded Upward Bound Math/Science summer programme for college-intending low-income high school students. The article explains each computer science term with real-life and mathematical examples, applies each term to the Tower of Hanoi puzzle solution, and describes how students connected the terms to their own solutions of the puzzle. It is timely and important to expose mathematics students to computer science concepts. Given the rate at which technology is currently advancing, and our increased dependence on technology in our daily lives, it has become more important than ever for children to be exposed to computer science. Yet, despite the importance of exposing today's children to computer science, many children are not given adequate opportunity to learn computer science in schools. In the United States, for example, most students finish high school without ever taking a computing course. Mathematics lessons, such as the one described in this article, can help to make computer science more accessible to students who may have otherwise had little opportunity to be introduced to these increasingly important concepts.

  10. Heavy quark dynamics in the QGP: Towards a solution of the RAA and ν2 puzzle

    NASA Astrophysics Data System (ADS)

    Scardina, F.; Das, S. K.; Plumari, S.; Greco, V.

    2016-05-01

    The two key observables related to heavy quarks that have been measured in experiments are the nuclear suppression factor RAA and the elliptic flow ν2. The simultaneous reproduction of these two observables is a puzzle which have challenged all the existing models. We discuss two ingredients responsible for addressing a large part of such a puzzle: the temperature dependence of the energy loss and the full solution of the Boltzmann collision integral for the scattering between the heavy quarks and the particle of the bulk.

  11. Jigsaw puzzle metasurface for multiple functions: polarization conversion, anomalous reflection and diffusion.

    PubMed

    Zhao, Yi; Cao, Xiangyu; Gao, Jun; Liu, Xiao; Li, Sijia

    2016-05-16

    We demonstrate a simple reconfigurable metasurface with multiple functions. Anisotropic tiles are investigated and manufactured as fundamental elements. Then, the tiles are combined in a certain sequence to construct a metasurface. Each of the tiles can be adjusted independently which is like a jigsaw puzzle and the whole metasurface can achieve diverse functions by different layouts. For demonstration purposes, we realize polarization conversion, anomalous reflection and diffusion by a jigsaw puzzle metasurface with 6 × 6 pieces of anisotropic tile. Simulated and measured results prove that our method offers a simple and effective strategy for metasurface design. PMID:27409942

  12. The Brain Explorer: Puzzles, Riddles, Illusions, and Other Mental Adventures. An Exploratorium Science-at-Home Book.

    ERIC Educational Resources Information Center

    Murphy, Pat; Klages, Ellen; Tesler, Pearl; Shore, Linda

    This book contains puzzles, riddles, illusions, experiments, and games for children ages 9-12. The experiments and activities teach students about the inner workings of their brain. Contents include: (1) "Caverns of Memory"; (2) "Forests of Hidden Treasure"; and (3) "The Puzzle House." (CCM)

  13. An Easy & Fun Way to Teach about How Science "Works": Popularizing Haack's Crossword-Puzzle Analogy

    ERIC Educational Resources Information Center

    Pavlova, Iglika V.; Lewis, Kayla C.

    2013-01-01

    Science is a complex process, and we must not teach our students overly simplified versions of "the" scientific method. We propose that students can uncover the complex realities of scientific thinking by exploring the similarities and differences between solving the familiar crossword puzzles and scientific "puzzles."…

  14. Utility of Self-Made Crossword Puzzles as an Active Learning Method to Study Biochemistry in Undergraduate Education

    ERIC Educational Resources Information Center

    Coticone, Sulekha Rao

    2013-01-01

    To incorporate an active learning component in a one-semester biochemistry course, students were asked to create crossword puzzles using key concepts. Student observations on the use of self-made crossword puzzles as an active-learning instructional tool were collected using a 5-point Likert survey at the end of the semester. A majority of the…

  15. Having Fun and Accepting Challenges Are Natural Instincts: Jigsaw Puzzles to Challenge Students and Test Their Abilities While Having Fun!

    ERIC Educational Resources Information Center

    Rodenbaugh, Hanna R.; Lujan, Heidi L.; Rodenbaugh, David W.; DiCarlo, Stephen E.

    2014-01-01

    Because jigsaw puzzles are fun, and challenging, students will endure and discover that persistence and grit are rewarded. Importantly, play and fun have a biological place just like sleep and dreams. Students also feel a sense of accomplishment when they have completed a puzzle. Importantly, the reward of mastering a challenge builds confidence…

  16. Letter Imperfect

    ERIC Educational Resources Information Center

    Kramer, Stephen

    2003-01-01

    In this essay, the author, a 5th-grade teacher, questions how well a standardized test can measure his students. This article presents a letter he wrote for the Washington state science test scorer regarding his students' test scores. He shares stories about some of the students in his class. He points out that tests can turn out to be more like…

  17. Connectives: Fitting Another Piece of the Vocabulary Instruction Puzzle

    ERIC Educational Resources Information Center

    Crosson, Amy C.; Lesaux, Nonie K.

    2013-01-01

    Connectives (e.g., although, consequently, in contrast) are often considered the "signposts" of texts. In this article we argue that connectives represent a special kind of vocabulary knowledge that students need to develop both in order to read challenging, academic texts with understanding and to produce academic writing. Yet tapping…

  18. Knowledge Management

    NASA Technical Reports Server (NTRS)

    Shariq, Syed Z.; Kutler, Paul (Technical Monitor)

    1997-01-01

    The emergence of rapidly expanding technologies for distribution and dissemination of information and knowledge has brought to focus the opportunities for development of knowledge-based networks, knowledge dissemination and knowledge management technologies and their potential applications for enhancing productivity of knowledge work. The challenging and complex problems of the future can be best addressed by developing the knowledge management as a new discipline based on an integrative synthesis of hard and soft sciences. A knowledge management professional society can provide a framework for catalyzing the development of proposed synthesis as well as serve as a focal point for coordination of professional activities in the strategic areas of education, research and technology development. Preliminary concepts for the development of the knowledge management discipline and the professional society are explored. Within this context of knowledge management discipline and the professional society, potential opportunities for application of information technologies for more effectively delivering or transferring information and knowledge (i.e., resulting from the NASA's Mission to Planet Earth) for the development of policy options in critical areas of national and global importance (i.e., policy decisions in economic and environmental areas) can be explored, particularly for those policy areas where a global collaborative knowledge network is likely to be critical to the acceptance of the policies.

  19. Jigsaw Puzzles and River Banks: Two Ways of Picturing Our Future

    ERIC Educational Resources Information Center

    Kretchmar, R. Scott

    2005-01-01

    The papers presented at the 2004 Academy meetings can be thought of as pieces from jigsaw puzzles. While the employment of this metaphor over the years has been useful, we may be ready for a new image, one that is both more accurate and inspiring. We can picture ourselves working at different locations along a river bank. Some of us work upstream,…

  20. Schooling, Cognitive Skills, and the Latin American Growth Puzzle. NBER Working Paper No. 15066

    ERIC Educational Resources Information Center

    Hanushek, Eric A.; Woessmann, Ludger

    2009-01-01

    Economic development in Latin America has trailed most other world regions over the past four decades despite its relatively high initial development and school attainment levels. This puzzle can be resolved by considering the actual learning as expressed in tests of cognitive skills, on which Latin American countries consistently perform at the…

  1. A Public-Key Based Authentication and Key Establishment Protocol Coupled with a Client Puzzle.

    ERIC Educational Resources Information Center

    Lee, M. C.; Fung, Chun-Kan

    2003-01-01

    Discusses network denial-of-service attacks which have become a security threat to the Internet community and suggests the need for reliable authentication protocols in client-server applications. Presents a public-key based authentication and key establishment protocol coupled with a client puzzle protocol and validates it through formal logic…

  2. Engaging Students in a Large Lecture: An Experiment Using Sudoku Puzzles

    ERIC Educational Resources Information Center

    Brophy, Caroline; Hahn, Lukas

    2014-01-01

    In this paper, we describe an in-class experiment that is easy to implement with large groups of students. The experiment takes approximately 15-20 minutes to run and involves each student completing one of four types of Sudoku puzzles and recording the time it takes to completion. The resulting data set can be used as a teaching tool at an…

  3. Parents' Attributions of Their Child's Jigsaw-Puzzle Performance: Comparing Two Genetic Syndromes

    ERIC Educational Resources Information Center

    Ly, Tran M.; Hodapp, Robert M.

    2005-01-01

    Parents' attributions of the jigsaw-puzzle performance of their child with Prader-Willi syndrome (n = 20) or Williams syndrome (n = 21) were examined. Parents in both groups placed more importance on internal versus external attributions. Parents of children with Prader-Willi syndrome exhibited a hedonic bias by attributing their child's success…

  4. The Quark Puzzle: A Novel Approach to Visualizing the Color Symmetries of Quarks

    ERIC Educational Resources Information Center

    Gettrust, Eric

    2010-01-01

    This paper describes a simple hands-on and visual-method designed to introduce physics students of many age groups to the topic of quarks and their role in forming composite particles (baryons and mesons). A set of puzzle pieces representing individual quarks that fit together in ways consistent with known restrictions of flavor, color, and charge…

  5. New Light on Autism and Other Puzzling Disorders of Childhood. Science Reports.

    ERIC Educational Resources Information Center

    Yahraes, Herbert

    The pamphlet discusses several puzzling disorders of childhood, including autism, atypical personality development (childhood psychosis), psychosocial dwarfism, and Tourette's syndrome. Psychosocial dwarfism is said to be characterized by a marked reduction in physical development and by immaturity in behavior, while Tourette's syndrome involves…

  6. Purim Puzzles and Laughs: A Project for Mixed-Ability Classes.

    ERIC Educational Resources Information Center

    Adler, Harry

    1996-01-01

    Discusses the use of puzzles and jokes to encourage student interest in an English-as-a-Second-Language class. The object of this project was to relate to a more human context, the playfulness that pushes aside arbitrary school time each spring when Purim comes. (CK)

  7. High-mass twins & resolution of the reconfinement, masquerade and hyperon puzzles of compact star interiors

    NASA Astrophysics Data System (ADS)

    Blaschke, David; Alvarez-Castillo, David E.

    2016-01-01

    We aim at contributing to the resolution of three of the fundamental puzzles related to the still unsolved problem of the structure of the dense core of compact stars (CS): (i) the hyperon puzzle: how to reconcile pulsar masses of 2 M⊙ with the hyperon softening of the equation of state (EoS); (ii) the masquerade problem: modern EoS for cold, high density hadronic and quark matter are almost identical; and (iii) the reconfinement puzzle: what to do when after a deconfinement transition the hadronic EoS becomes favorable again? We show that taking into account the compositeness of baryons (by excluded volume and/or quark Pauli blocking) on the hadronic side and confining and stiffening effects on the quark matter side results in an early phase transition to quark matter with sufficient stiffening at high densities which removes all three present-day puzzles of CS interiors. Moreover, in this new class of EoS for hybrid CS falls the interesting case of a strong first order phase transition which results in the observable high mass twin star phenomenon, an astrophysical observation of a critical endpoint in the QCD phase diagram.

  8. Puzzling Moments, Teachable Moments: Practicing Teacher Research in Urban Classrooms. Practitioners Inquiry Series

    ERIC Educational Resources Information Center

    Ballenger, Cynthia

    2009-01-01

    In her new book, bestselling author Cynthia Ballenger explores the intellectual strengths of students that teachers find "puzzling"--poor, urban, immigrant, or bilingual children who do not traditionally excel in school. Ballenger challenges the assumption that these children--whose families in many cases have less formal education, read fewer…

  9. (Mis)perception of Sleep in Insomnia: A Puzzle and a Resolution

    ERIC Educational Resources Information Center

    Harvey, Allison G.; Tang, Nicole K. Y.

    2012-01-01

    Insomnia is prevalent, causing severe distress and impairment. This review focuses on illuminating the puzzling finding that many insomnia patients misperceive their sleep. They overestimate their sleep onset latency (SOL) and underestimate their total sleep time (TST), relative to objective measures. This tendency is ubiquitous (although not…

  10. The Role of Inhibitory Control in Children's Cooperative Behaviors during a Structured Puzzle Task

    ERIC Educational Resources Information Center

    Giannotta, Fabrizia; Burk, William J.; Ciairano, Silvia

    2011-01-01

    This study examined the role of inhibitory control (measured by Stroop interference) in children's cooperative behaviors during a structured puzzle task. The sample consisted of 250 8-, 10-, and 12-year-olds (117 girls and 133 boys) attending classrooms in three primary schools in Northern Italy. Children individually completed an elaborated…

  11. Enhancing the Understanding of Government and Nonprofit Accounting with THE PUZZLE GAME: A Pilot Study

    ERIC Educational Resources Information Center

    Elson, Raymond J.; Ostapski, S. Andrew; O'Callaghan, Susanne; Walker, John P.

    2012-01-01

    Nontraditional teaching aids such as crossword puzzles have been successfully used in the classroom to enhance student learning. Government and nonprofit accounting is a confusing course for students since it has strange terminologies and contradicts the accounting concepts learned in other courses. As such, it is an ideal course for a…

  12. Gardner's Two Children Problems and Variations: Puzzles with Conditional Probability and Sample Spaces

    ERIC Educational Resources Information Center

    Taylor, Wendy; Stacey, Kaye

    2014-01-01

    This article presents "The Two Children Problem," published by Martin Gardner, who wrote a famous and widely-read math puzzle column in the magazine "Scientific American," and a problem presented by puzzler Gary Foshee. This paper explains the paradox of Problems 2 and 3 and many other variations of the theme. Then the authors…

  13. (Mis)Aligned Ambitions? Parent Resources, Student Alignment, and Piecing Together the Hispanic College Puzzle

    ERIC Educational Resources Information Center

    Ryan, Sarah Margaret

    2012-01-01

    The fact that Latina/o students are losing ground to their non-Latino White peers in four-year college enrollment and bachelor's degree attainment even as Latino college enrollment and graduation rates are at an all time high constitutes a perplexing puzzle. In order to realize the potential "demographic dividend" embedded in the…

  14. Understanding the proton radius puzzle: Nuclear structure effects in light muonic atoms

    NASA Astrophysics Data System (ADS)

    Ji, Chen; Hernandez, Oscar Javier; Nevo Dinur, Nir; Bacca, Sonia; Barnea, Nir

    2016-03-01

    We present calculations of nuclear structure effects to the Lamb shift in light muonic atoms. We adopt a modern ab-initio approach by combining state-of-the-art nuclear potentials with the hyperspherical harmonics method. Our calculations are instrumental to the determination of nuclear charge radii in the Lamb shift measurements, which will shed light on the proton radius puzzle.

  15. The Retention Puzzle Reconsidered: Second Year Student Attitudes and Experiences with Advising

    ERIC Educational Resources Information Center

    Walsh, Michael Edward

    2013-01-01

    College student retention has been described as a puzzle because retention rates have stagnated, and in some cases declined, despite over seventy years of research into the problem. The magnitude of the problem is that 50 percent of college students will leave their institution before obtaining a degree (Braxton, Hirschy, & McClendon, 2011).…

  16. Instructional Media Production for Early Childhood Education: A. B. C. Jig-Saw Puzzle, a Model

    ERIC Educational Resources Information Center

    Yusuf, Mudashiru Olalere; Olanrewaju, Olatayo Solomon; Soetan, Aderonke K.

    2015-01-01

    In this paper, a. b. c. jig-saw puzzle was produced for early childhood education using local materials. This study was a production based type of research, to serve as a supplemental or total learning resource. Its production followed four phases of development referred to as information, design, production and evaluation. The storyboard cards,…

  17. A Guide to Puzzles and Games in Second Language Pedagogy. Language and Literacy Series.

    ERIC Educational Resources Information Center

    Danesi, Marcel

    This guide presents, discusses and describes a selection of games and puzzles for school second language instruction. The first chapter discusses the value of these activities in language teaching, including the psychology of problem-solving, the process of motivating and involving students, three key questions to ask about games in the classroom…

  18. Sequential Monte Carlo for Maximum Weight Subgraphs with Application to Solving Image Jigsaw Puzzles

    PubMed Central

    Adluru, Nagesh; Yang, Xingwei; Latecki, Longin Jan

    2015-01-01

    We consider a problem of finding maximum weight subgraphs (MWS) that satisfy hard constraints in a weighted graph. The constraints specify the graph nodes that must belong to the solution as well as mutual exclusions of graph nodes, i.e., pairs of nodes that cannot belong to the same solution. Our main contribution is a novel inference approach for solving this problem in a sequential monte carlo (SMC) sampling framework. Usually in an SMC framework there is a natural ordering of the states of the samples. The order typically depends on observations about the states or on the annealing setup used. In many applications (e.g., image jigsaw puzzle problems), all observations (e.g., puzzle pieces) are given at once and it is hard to define a natural ordering. Therefore, we relax the assumption of having ordered observations about states and propose a novel SMC algorithm for obtaining maximum a posteriori estimate of a high-dimensional posterior distribution. This is achieved by exploring different orders of states and selecting the most informative permutations in each step of the sampling. Our experimental results demonstrate that the proposed inference framework significantly outperforms loopy belief propagation in solving the image jigsaw puzzle problem. In particular, our inference quadruples the accuracy of the puzzle assembly compared to that of loopy belief propagation. PMID:26052182

  19. Wave propagation in semi-infinite bar with random imperfections of density and elasticity module

    NASA Astrophysics Data System (ADS)

    Náprstek, J.

    2008-02-01

    Mathematical modeling and properties of a linear longitudinal wave propagating in a slender bar with random imperfections of material density and Young modulus of elasticity is discussed. Fluctuation components of material properties are considered as continuous stochastic functions of the length coordinate. Two types of fluctuation and their influence on response properties have been investigated, in particular the delta correlated and a diffusion-type processes. Investigation itself is based on Markov processes and corresponding Fokker-Planck-Kolmogorov equation. The stochastic moments closure as a solution method has been used. Many effects due to the stochastic nature of the problem have been detected. Along the bar a drop of the mean value of the response with the simultaneous increase of the response variance have been observed. This effect does not represent any conventional damping, but a gradual drop of the deterministic and an increase of the stochastic components of the overall response. The rate of the response indeterminacy increases with the increase of the length coordinate. Increasing values of material imperfection variances and the rising excitation frequency can lead to a critical state when the length of the propagating wave is comparable with the correlation length of imperfections. This state will manifest itself as a radical change of the response character. The problem will pass beyond the boundaries of stochastic mechanics and lose its physical meaning. Similar effects can be observed in the FEM analysis, where there is also a certain permissible upper boundary of the excitation frequency corresponding with the size and type of the element used.

  20. Development of a diagnostic test based on multiple continuous biomarkers with an imperfect reference test.

    PubMed

    García Barrado, Leandro; Coart, Els; Burzykowski, Tomasz

    2016-02-20

    Ignoring the fact that the reference test used to establish the discriminative properties of a combination of diagnostic biomarkers is imperfect can lead to a biased estimate of the diagnostic accuracy of the combination. In this paper, we propose a Bayesian latent-class mixture model to select a combination of biomarkers that maximizes the area under the ROC curve (AUC), while taking into account the imperfect nature of the reference test. In particular, a method for specification of the prior for the mixture component parameters is developed that allows controlling the amount of prior information provided for the AUC. The properties of the model are evaluated by using a simulation study and an application to real data from Alzheimer's disease research. In the simulation study, 100 data sets are simulated for sample sizes ranging from 100 to 600 observations, with a varying correlation between biomarkers. The inclusion of an informative as well as a flat prior for the diagnostic accuracy of the reference test is investigated. In the real-data application, the proposed model was compared with the generally used logistic-regression model that ignores the imperfectness of the reference test. Conditional on the selected sample size and prior distributions, the simulation study results indicate satisfactory performance of the model-based estimates. In particular, the obtained average estimates for all parameters are close to the true values. For the real-data application, AUC estimates for the proposed model are substantially higher than those from the 'traditional' logistic-regression model. PMID:26388206

  1. Automated knowledge-base refinement

    NASA Technical Reports Server (NTRS)

    Mooney, Raymond J.

    1994-01-01

    Over the last several years, we have developed several systems for automatically refining incomplete and incorrect knowledge bases. These systems are given an imperfect rule base and a set of training examples and minimally modify the knowledge base to make it consistent with the examples. One of our most recent systems, FORTE, revises first-order Horn-clause knowledge bases. This system can be viewed as automatically debugging Prolog programs based on examples of correct and incorrect I/O pairs. In fact, we have already used the system to debug simple Prolog programs written by students in a programming language course. FORTE has also been used to automatically induce and revise qualitative models of several continuous dynamic devices from qualitative behavior traces. For example, it has been used to induce and revise a qualitative model of a portion of the Reaction Control System (RCS) of the NASA Space Shuttle. By fitting a correct model of this portion of the RCS to simulated qualitative data from a faulty system, FORTE was also able to correctly diagnose simple faults in this system.

  2. Z-scan characterization of optical nonlinearities of an imperfect sample profits from radially polarized beams

    NASA Astrophysics Data System (ADS)

    Gu, Bing; Liu, Dahui; Wu, Jia-Lu; He, Jun; Cui, Yiping

    2014-12-01

    We present the Z-scan technique using azimuthal-variant vector beams for characterizing the nonlinear refractive index of an isotropic nonlinear medium. Compared with the conventional Z-scan measurements, the reliability of the vector beam Z-scan is improved because the focused azimuthal-variant vector beam exhibits a uniform-intensity focal ring instead of a focal spot. Experimentally, our investigation demonstrates that the Z-scan using radially polarized beams is a preferable technique for characterizing the optical nonlinearity of an imperfect sample.

  3. Imperfection and Thickness Measurement of Panels Using a Coordinate Measurement Machine

    NASA Technical Reports Server (NTRS)

    Thornburgh, Robert P.

    2006-01-01

    This paper summarizes the methodology used to measure imperfection and thickness variation for flat and curved panels using a Coordinate Measurement Machine (CMM) and the software program MeasPanel. The objective is to provide a reference document so that someone with a basic understanding of CMM operation can measure a panel with minimal training. Detailed information about both the measurement system setup and computer software is provided. Information is also provided about the format of the raw data, as well as how it is post-processed for use in finite-element analysis.

  4. Requirements for a loophole-free photonic Bell test using imperfect setting generators

    NASA Astrophysics Data System (ADS)

    Kofler, Johannes; Giustina, Marissa; Larsson, Jan-Åke; Mitchell, Morgan W.

    2016-03-01

    Experimental violations of Bell inequalities are in general vulnerable to so-called loopholes. In this work, we analyze the characteristics of a loophole-free Bell test with photons, closing simultaneously the locality, freedom-of-choice, fair-sampling (i.e., detection), coincidence-time, and memory loopholes. We pay special attention to the effect of excess predictability in the setting choices due to nonideal random-number generators. We discuss necessary adaptations of the Clauser-Horne and Eberhard inequality when using such imperfect devices and—using Hoeffding's inequality and Doob's optional stopping theorem—the statistical analysis in such Bell tests.

  5. Effects of mass layer imperfect bonding on the electrical impedance of a quartz crystal microbalance

    NASA Astrophysics Data System (ADS)

    Chen, YangYang; Wang, Ji; Du, JianKe; Yang, JiaShi

    2013-11-01

    We study electrically forced vibrations of a crystal plate of AT-cut quartz carrying a thin mass layer operating as a quartz crystal microbalance for mass sensing. The mass layer is imperfectly bonded to the crystal plate with their interface described by the so-called interface-slip model which allows a discontinuity of the tangential interface displacement. Mindlin's equations for piezoelectric plates are used. An analytical solution is obtained. The electrical impedance is calculated. The effects of an elastic interface and a viscoelastic interface are examined.

  6. Assessing the utility of statistical adjustments for imperfect detection in tropical conservation science

    PubMed Central

    Banks-Leite, Cristina; Pardini, Renata; Boscolo, Danilo; Cassano, Camila Righetto; Püttker, Thomas; Barros, Camila Santos; Barlow, Jos

    2014-01-01

    1. In recent years, there has been a fast development of models that adjust for imperfect detection. These models have revolutionized the analysis of field data, and their use has repeatedly demonstrated the importance of sampling design and data quality. There are, however, several practical limitations associated with the use of detectability models which restrict their relevance to tropical conservation science. 2. We outline the main advantages of detectability models, before examining their limitations associated with their applicability to the analysis of tropical communities, rare species and large-scale data sets. Finally, we discuss whether detection probability needs to be controlled before and/or after data collection. 3. Models that adjust for imperfect detection allow ecologists to assess data quality by estimating uncertainty and to obtain adjusted ecological estimates of populations and communities. Importantly, these models have allowed informed decisions to be made about the conservation and management of target species. 4. Data requirements for obtaining unadjusted estimates are substantially lower than for detectability-adjusted estimates, which require relatively high detection/recapture probabilities and a number of repeated surveys at each location. These requirements can be difficult to meet in large-scale environmental studies where high levels of spatial replication are needed, or in the tropics where communities are composed of many naturally rare species. However, while imperfect detection can only be adjusted statistically, covariates of detection probability can also be controlled through study design. Using three study cases where we controlled for covariates of detection probability through sampling design, we show that the variation in unadjusted ecological estimates from nearly 100 species was qualitatively the same as that obtained from adjusted estimates. Finally, we discuss that the decision as to whether one should control for

  7. On continuous-time two person full-information best choice problem with imperfect observation

    SciTech Connect

    Porosinski, Z.; Szajowski, K.

    1994-12-31

    A zero-sum game version of the continuous-time full-information best choice problem is considered. Two players observe sequentially a stream of iid random variables from a known continuous distribution appearing according to some renewal process with the object of choosing the largest one. The horizon of observation is a positive random variable independent of observations. The observations of the random variables are imperfect and the players are informed only whether it is greater than or less than some levels specified by both of them. The normal form of the game is derived. Poisson horizon case is examined in detail.

  8. Change in the structural imperfection of lithium niobate crystals doped with zinc

    SciTech Connect

    Litvinova, V. A. Litvinova, M. N.

    2015-01-15

    The changes in the degree of structural imperfection of lithium niobate (LiNbO{sub 3}) single crystals with an increase in the Li content and doping with zinc (to 1 wt %) have been investigated by the nonlinear optics methods and Raman spectroscopy. The conversion of broadband IR radiation in LiNbO{sub 3} crystals under noncritical (90°) phase-matching condition with vector interactions implemented is investigated. It is shown that the conversion efficiency, spectral width, and the position of maximum in the converted radiation spectrum depend on the ratio R = Li/Nb in LiNbO{sub 3} crystal and the impurity concentration.

  9. a Diffusive-Transport Approach to Determine the Electrical Conductance of AN Imperfect Multiwalled Carbon Nanotube

    NASA Astrophysics Data System (ADS)

    Grado-Caffaro, Maria Angeles; Grado-Caffaro, Martin

    2014-05-01

    In this paper, we propose a diffusive-transport-based analytical formulation to calculate the linear electrical conductance through a multiwalled carbon nanotube with defects. In fact, on the one hand, by considerations on diffusive transport and, on the other hand, using the Drude model, we find out that the conductance (at Fermi energy) of an imperfect multiwalled carbon nanotube is approximately equal to the fundamental conductance quantum multiplied by the number of layers (or shells) of the tube. Our result agrees with experimental data.

  10. Put Your Imperfections Behind You: Temporal Landmarks Spur Goal Initiation When They Signal New Beginnings.

    PubMed

    Dai, Hengchen; Milkman, Katherine L; Riis, Jason

    2015-12-01

    People often fail to muster the motivation needed to initiate goal pursuit. Across five laboratory experiments, we explored occasions when people naturally experience enhanced motivation to take actions that facilitate goal pursuit and why certain dates are more likely to spur goal initiation than others. We present causal evidence that emphasizing a temporal landmark denoting the beginning of a new time period increases people's intentions to initiate goal pursuit. In addition, we propose and show that people's strengthened motivation to begin pursuing their aspirations following such temporal landmarks originates in part from the psychological disassociation these landmarks induce from a person's past, imperfect self. PMID:26546079

  11. Broadband second harmonic generation in an imperfect nonlinear photonic crystal with random defects

    NASA Astrophysics Data System (ADS)

    Ren, Kun; Liu, Yali; Ren, Xiaobin; Fan, Jingyang

    2016-09-01

    In this paper, we study broadband second harmonic generation (SHG) in an imperfect nonlinear photonic crystal in which defects are introduced with random lengths. We show that the efficient SHG output is obtained when the length of each defect varies near certain specialized values. The bandwidth of the SHG output broadens with the increasing randomness of defect length. Moreover, the SHG bandwidth is nearly unaffected only when the total length of the whole structure is long enough. The disordered structure also exhibits good tolerance to the fabrication error, which provides a way to control SHG intensity and bandwidth separately.

  12. The missing piece in the acid-rain puzzle

    SciTech Connect

    Powicki, C.R.

    1989-09-01

    This article discusses the role of geology in acid precipitation research and water quality. Knowledge of the composition and reactivity of the soil and bedrock through which acid precipitation flows is necessary to predict its effects on a body of water. Acidification not only has direct impacts, through water quality changes in water bodies, but also indirect long-term effects attributable to weathering rates. Once the capacity of the soil to buffer acidic loading is exceeded, sudden changes in soil chemistry may occur with dramatic effects on dependent biota.

  13. Imperfectly synchronized states and chimera states in two interacting populations of nonlocally coupled Stuart-Landau oscillators.

    PubMed

    Premalatha, K; Chandrasekar, V K; Senthilvelan, M; Lakshmanan, M

    2016-07-01

    We investigate the emergence of different kinds of imperfectly synchronized states and chimera states in two interacting populations of nonlocally coupled Stuart-Landau oscillators. We find that the complete synchronization in population I and existence of solitary oscillators which escape from the synchronized group in population II lead to imperfectly synchronized states for sufficiently small values of nonisochronicity parameter. Interestingly, upon increasing the strength of this parameter further there occurs an onset of mixed imperfectly synchronized states where the solitary oscillators occur from both the populations. Synchronized oscillators from both the populations are locked to a common average frequency. In both cases of imperfectly synchronized states, synchronized oscillators exhibit periodic motion while the solitary oscillators are quasiperiodic in nature. In this region, for spatially prepared initial conditions, we can observe the mixed chimera states where the coexistence of synchronized and desynchronized oscillations occur from both the populations. On the other hand, imperfectly synchronized states are not always stable, and they can drift aperiodically due to instability caused by an increase of nonisochronicity parameter. We observe that these states are robust to the introduction of frequency mismatch between the two populations. PMID:27575152

  14. Imperfectly synchronized states and chimera states in two interacting populations of nonlocally coupled Stuart-Landau oscillators

    NASA Astrophysics Data System (ADS)

    Premalatha, K.; Chandrasekar, V. K.; Senthilvelan, M.; Lakshmanan, M.

    2016-07-01

    We investigate the emergence of different kinds of imperfectly synchronized states and chimera states in two interacting populations of nonlocally coupled Stuart-Landau oscillators. We find that the complete synchronization in population I and existence of solitary oscillators which escape from the synchronized group in population II lead to imperfectly synchronized states for sufficiently small values of nonisochronicity parameter. Interestingly, upon increasing the strength of this parameter further there occurs an onset of mixed imperfectly synchronized states where the solitary oscillators occur from both the populations. Synchronized oscillators from both the populations are locked to a common average frequency. In both cases of imperfectly synchronized states, synchronized oscillators exhibit periodic motion while the solitary oscillators are quasiperiodic in nature. In this region, for spatially prepared initial conditions, we can observe the mixed chimera states where the coexistence of synchronized and desynchronized oscillations occur from both the populations. On the other hand, imperfectly synchronized states are not always stable, and they can drift aperiodically due to instability caused by an increase of nonisochronicity parameter. We observe that these states are robust to the introduction of frequency mismatch between the two populations.

  15. Structural design considerations for stretched-membrane heliostat reflector modules with stability and initial imperfection considerations

    SciTech Connect

    Murphy, L.M.; Simms, D.; Sallis, D.V.

    1986-10-01

    This report extends the work of several previous reports that present the background leading to the development of stretched-membrane modules and analysis methods to study the structural response of the stretched-membrane module. Specifically, this report presents and discusses the design implications based on our analysis of single- or double-membrane concepts, and the amplification of initial imperfections and deflections caused by loading, which results from stability considerations. In this document, we present analysis results for both single- and double-membrane concepts corresponding to a range of design and loading conditions. Further, we show that stretched-membrane/frame combinations respond quite differently to external loads than can be inferred by studying the decoupled frame and membrane independently. Thus the coupled membrane/frame problem should be considered to assure an accurate description of its response. For idealized configurations and loadings, we discuss the relative merits of various design features for both of these designs. In addition, we studied the structural stability (i.e., the tendency of structural deformation to grow with little increase in applied load) of the tensioned-membrane, compressed-frame combination. Moreover, we demonstrate how stability considerations are important in determining the amplification of both initial displacement imperfection and the deformations caused by wind and weight loading on the structure.

  16. An Information-Theoretic Framework for Improving Imperfect Dynamical Predictions Via Multi-Model Ensemble Forecasts

    NASA Astrophysics Data System (ADS)

    Branicki, Michal; Majda, Andrew J.

    2015-06-01

    This work focuses on elucidating issues related to an increasingly common technique of multi-model ensemble (MME) forecasting. The MME approach is aimed at improving the statistical accuracy of imperfect time-dependent predictions by combining information from a collection of reduced-order dynamical models. Despite some operational evidence in support of the MME strategy for mitigating the prediction error, the mathematical framework justifying this approach has been lacking. Here, this problem is considered within a probabilistic/stochastic framework which exploits tools from information theory to derive a set of criteria for improving probabilistic MME predictions relative to single-model predictions. The emphasis is on a systematic understanding of the benefits and limitations associated with the MME approach, on uncertainty quantification, and on the development of practical design principles for constructing an MME with improved predictive performance. The conditions for prediction improvement via the MME approach stem from the convexity of the relative entropy which is used here as a measure of the lack of information in the imperfect models relative to the resolved characteristics of the truth dynamics. It is also shown how practical guidelines for MME prediction improvement can be implemented in the context of forced response predictions from equilibrium with the help of the linear response theory utilizing the fluctuation-dissipation formulas at the unperturbed equilibrium. The general theoretical results are illustrated using exactly solvable stochastic non-Gaussian test models.

  17. The Study of Imperfection in Rough Set on the Field of Engineering and Education

    NASA Astrophysics Data System (ADS)

    Sheu, Tian-Wei; Liang, Jung-Chin; You, Mei-Li; Wen, Kun-Li

    Based on the characteristic of rough set, rough set theory overlaps with many other theories, especially with fuzzy set theory, evidence theory and Boolean reasoning methods. And the rough set methodology has found many real-life applications, such as medical data analysis, finance, banking, engineering, voice recognition, image processing and others. Till now, there is rare research associating to this issue in the imperfection of rough set. Hence, the main purpose of this paper is to study the imperfection of rough set in the field of engineering and education. First of all, we preview the mathematics model of rough set, and a given two examples to enhance our approach, which one is the weighting of influence factor in muzzle noise suppressor, and the other is the weighting of evaluation factor in English learning. Third, we also apply Matlab to develop a complete human-machine interface type of toolbox in order to support the complex calculation and verification the huge data. Finally, some further suggestions are indicated for the research in the future.

  18. Stabilization of perfect and imperfect tandem repeats by single-strand DNA exonucleases.

    PubMed

    Feschenko, Vladimir V; Rajman, Luis A; Lovett, Susan T

    2003-02-01

    Rearrangements between tandemly repeated DNA sequences are a common source of genetic instability. Such rearrangements underlie several human genetic diseases. In many organisms, the mismatch-repair (MMR) system functions to stabilize repeats when the repeat unit is short or when sequence imperfections are present between the repeats. We show here that the action of single-stranded DNA (ssDNA) exonucleases plays an additional, important role in stabilizing tandem repeats, independent of their role in MMR. For perfect repeats of approximately 100 bp in Escherichia coli that are not susceptible to MMR, exonuclease (Exo)-I, ExoX, and RecJ exonuclease redundantly inhibit deletion. Our data suggest that >90% of potential deletion events are avoided by the combined action of these three exonucleases. Imperfect tandem repeats, less prone to rearrangements, are stabilized by both the MMR-pathway and ssDNA-specific exonucleases. For 100-bp repeats containing four mispairs, ExoI alone aborts most deletion events, even in the presence of a functional MMR system. By genetic analysis, we show that the inhibitory effect of ssDNA exonucleases on deletion formation is independent of the MutS and UvrD proteins. Exonuclease degradation of DNA displaced during the deletion process may abort slipped misalignment. Exonuclease action is therefore a significant force in genetic stabilization of many forms of repetitive DNA. PMID:12538867

  19. Coordinating vendor-buyer decisions for imperfect quality items considering trade credit and fully backlogged shortages

    NASA Astrophysics Data System (ADS)

    Khanna, Aditi; Gautam, Prerna; Jaggi, Chandra K.

    2016-03-01

    Supply chain management has become a critical issue for modern business environments. In today's world of cooperative decision-making, individual decisions in order to reduce inventory costs may not lead to an overall optimal solution. Coordination is necessary among participants of supply chain to achieve better performance. There are legitimate and important efforts from the vendor to enhance the relation with buyer; one such effort is offering trade credit which has been a driver of growth and development of business between them. The cost of financing is a core consideration in effective financial management, in general and in context of business. Also, due to imperfect production a vendor may produce defective items which results in shortages. Motivated with these aspects, an integrated vendor-buyer inventory model is developed for imperfect quality items with allowable shortages; in which the vendor offers credit period to the buyer for payment. The objective is to minimize the total joint annual costs incurred by the vendor and the buyer by using integrated decision making approach. The expected total annual integrated cost is derived and a solution procedure is provided to find the optimal solution. Numerical analysis shows that the integrated model gives an impressive cost reduction, in comparison to independent decision policies by the vendor and the buyer.

  20. Improved signal detection for two-way wireless relaying networks under imperfect time synchronisation

    NASA Astrophysics Data System (ADS)

    O El Astal, Mohammed Taha; Olivier, Jan Corné

    2014-12-01

    Most research on two-way wireless relaying networks (TWRNs) assumes perfect time synchronisation between the terminals and among the relays. This is, however, difficult to accomplish as the terminals and relays are randomly located. The lack of synchronisation causes inter-symbol interference which introduces a serious impairment and negatively impacts the network's performance. In this article, an enhanced interference cancellation (EIC)-based detector is proposed to mitigate the experienced performance degradation while maintaining low complexity. It uses an innovative iterative approach and also benefits of interference components of currently detected symbols using a modified maximum likelihood (ML) scheme. As a result, it shows significant performance improvement compared to the conventional detector under different conditions of imperfect synchronisation. In addition, two existing interference cancellation detectors that are originally proposed for one-way WRNs are extended to TWRNs, even though the timing error among the terminals is a unique issue for TWRNs and never occurs in one-way networks. Unlike the existing literature, the proposed detectors apply to networks with an arbitrary number of multiple-antenna relays. Numerical simulation is provided in terms of bit error rate, to show the improvement in performance when compared to the conventional detector. Moreover, it is shown that the EIC detector outperforms the extended detectors and provides 3 to 4 dB gain under moderate condition of imperfect synchronisation.

  1. The effect of system aesthetics on trust, cooperation, satisfaction and annoyance in an imperfect automated system.

    PubMed

    Weinstock, Alona; Oron-Gilad, Tal; Parmet, Yisrael

    2012-01-01

    Lack of system reliability has been repeatedly identified as a factor that decreases trust. However, aesthetics has an important role in the development of trust. Most of the research concerning the connection between aesthetics and trust focused on mobile commerce and websites while very little has been done in examining aesthetics in automated systems. This study integrated aesthetics manipulations into an imperfect in-vehicle automation system and focused on the power of aesthetics to decrease the negative effects of errors on trust, satisfaction, annoyance, and human-automation cooperation perceptions. Participants used the navigation system in either 100% or 85% accuracy levels with an aesthetic or non aesthetic system (4 conditions). In both aesthetic and non aesthetic systems, perceptions of trust, satisfaction and human automation cooperation were decreased in the imperfect system compared to the perfect one. However, in the annoyance rating, this trend was found only in the aesthetic system while in the non-aesthetic system no difference was found between the two levels of accuracy. This single effect may indicate upon the possibility that in automated systems aesthetics affects trust and satisfaction more moderately compared to mobile commerce applications and websites. However, more research is needed to assess this assumption. PMID:22316732

  2. Finite-key security analysis of quantum key distribution with imperfect light sources

    NASA Astrophysics Data System (ADS)

    Mizutani, Akihiro; Curty, Marcos; Lim, Charles Ci Wen; Imoto, Nobuyuki; Tamaki, Kiyoshi

    2015-09-01

    In recent years, the gap between theory and practice in quantum key distribution (QKD) has been significantly narrowed, particularly for QKD systems with arbitrarily flawed optical receivers. The status for QKD systems with imperfect light sources is however less satisfactory, in the sense that the resulting secure key rates are often overly dependent on the quality of state preparation. This is especially the case when the channel loss is high. Very recently, to overcome this limitation, Tamaki et al proposed a QKD protocol based on the so-called ‘rejected data analysis’, and showed that its security—in the limit of infinitely long keys—is almost independent of any encoding flaw in the qubit space, being this protocol compatible with the decoy state method. Here, as a step towards practical QKD, we show that a similar conclusion is reached in the finite-key regime, even when the intensity of the light source is unstable. More concretely, we derive security bounds for a wide class of realistic light sources and show that the bounds are also efficient in the presence of high channel loss. Our results strongly suggest the feasibility of long distance provably secure communication with imperfect light sources.

  3. Shimming Halbach magnets utilizing genetic algorithms to profit from material imperfections

    NASA Astrophysics Data System (ADS)

    Parker, Anna J.; Zia, Wasif; Rehorn, Christian W. G.; Blümich, Bernhard

    2016-04-01

    In recent years, permanent magnet-based NMR spectrometers have resurfaced as low-cost portable alternatives to superconducting instruments. While the development of these devices as well as clever shimming methods have yielded impressive advancements, scaling the size of these magnets to miniature lengths remains a problem to be addressed. Here we present the results of a study of a discrete shimming scheme for NMR Mandhalas constructed from a set of individual magnet blocks. While our calculations predict a modest reduction in field deviation by a factor of 9.3 in the case of the shimmed ideal Mandhala, a factor of 28 is obtained in the case of the shimmed imperfect Mandhala. This indicates that imperfections of magnet blocks can lead to improved field homogeneity. We also present a new algorithm to improve the homogeneity of a permanent magnet assembly. Strategies for future magnet construction can improve the agreement between simulation and practical implementation by using data from real magnets in these assemblies as the input to such an algorithm to optimize the homogeneity of a given design.

  4. Finite-key security analysis of quantum key distribution with imperfect light sources

    SciTech Connect

    Mizutani, Akihiro; Curty, Marcos; Lim, Charles Ci Wen; Imoto, Nobuyuki; Tamaki, Kiyoshi

    2015-09-09

    In recent years, the gap between theory and practice in quantum key distribution (QKD) has been significantly narrowed, particularly for QKD systems with arbitrarily flawed optical receivers. The status for QKD systems with imperfect light sources is however less satisfactory, in the sense that the resulting secure key rates are often overly dependent on the quality of state preparation. This is especially the case when the channel loss is high. Very recently, to overcome this limitation, Tamaki et al proposed a QKD protocol based on the so-called 'rejected data analysis', and showed that its security in the limit of infinitely long keys is almost independent of any encoding flaw in the qubit space, being this protocol compatible with the decoy state method. Here, as a step towards practical QKD, we show that a similar conclusion is reached in the finite-key regime, even when the intensity of the light source is unstable. More concretely, we derive security bounds for a wide class of realistic light sources and show that the bounds are also efficient in the presence of high channel loss. Our results strongly suggest the feasibility of long distance provably secure communication with imperfect light sources.

  5. Experimental measurement-device-independent quantum key distribution with imperfect sources

    NASA Astrophysics Data System (ADS)

    Tang, Zhiyuan; Wei, Kejin; Bedroya, Olinka; Qian, Li; Lo, Hoi-Kwong

    2016-04-01

    Measurement-device-independent quantum key distribution (MDI-QKD), which is immune to all detector side-channel attacks, is the most promising solution to the security issues in practical quantum key distribution systems. Although several experimental demonstrations of MDI-QKD have been reported, they all make one crucial but not yet verified assumption, that is, there are no flaws in state preparation. Such an assumption is unrealistic and security loopholes remain in the source. Here we present a MDI-QKD experiment with the modulation error taken into consideration. By applying the loss-tolerant security proof by Tamaki et al. [Phys. Rev. A 90, 052314 (2014)], 10.1103/PhysRevA.90.052314, we distribute secure keys over fiber links up to 40 km with imperfect sources, which would not have been possible under previous security proofs. By simultaneously closing loopholes at the detectors and a critical loophole—modulation error in the source, our work shows the feasibility of secure QKD with practical imperfect devices.

  6. Shimming Halbach magnets utilizing genetic algorithms to profit from material imperfections.

    PubMed

    Parker, Anna J; Zia, Wasif; Rehorn, Christian W G; Blümich, Bernhard

    2016-04-01

    In recent years, permanent magnet-based NMR spectrometers have resurfaced as low-cost portable alternatives to superconducting instruments. While the development of these devices as well as clever shimming methods have yielded impressive advancements, scaling the size of these magnets to miniature lengths remains a problem to be addressed. Here we present the results of a study of a discrete shimming scheme for NMR Mandhalas constructed from a set of individual magnet blocks. While our calculations predict a modest reduction in field deviation by a factor of 9.3 in the case of the shimmed ideal Mandhala, a factor of 28 is obtained in the case of the shimmed imperfect Mandhala. This indicates that imperfections of magnet blocks can lead to improved field homogeneity. We also present a new algorithm to improve the homogeneity of a permanent magnet assembly. Strategies for future magnet construction can improve the agreement between simulation and practical implementation by using data from real magnets in these assemblies as the input to such an algorithm to optimize the homogeneity of a given design. PMID:26874333

  7. Diffraction and imaging study of imperfections of crystallized lysozyme with coherent X-rays

    NASA Technical Reports Server (NTRS)

    Hu, Z. W.; Chu, Y. S.; Lai, B.; Thomas, B. R.; Chernov, A. A.

    2004-01-01

    Phase-contrast X-ray diffraction imaging and high-angular-resolution diffraction combined with phase-contrast radiographic imaging were employed to characterize defects and perfection of a uniformly grown tetragonal lysozyme crystal in the symmetric Laue case. The full-width at half-maximum (FWHM) of a 4 4 0 rocking curve measured from the original crystal was approximately 16.7 arcsec and imperfections including line defects, inclusions and other microdefects were observed in the diffraction images of the crystal. The observed line defects carry distinct dislocation features running approximately along the <1 1 0> growth front and have been found to originate mostly in a central growth area and occasionally in outer growth regions. Inclusions of impurities or formations of foreign particles in the central growth region are resolved in the images with high sensitivity to defects. Slow dehydration led to the broadening of a fairly symmetric 4 4 0 rocking curve by a factor of approximately 2.6, which was primarily attributed to the dehydration-induced microscopic effects that are clearly shown in X-ray diffraction images. The details of the observed defects and the significant change in the revealed microstructures with drying provide insight into the nature of imperfections, nucleation and growth, and the properties of protein crystals.

  8. Finite-key security analysis of quantum key distribution with imperfect light sources

    DOE PAGESBeta

    Mizutani, Akihiro; Curty, Marcos; Lim, Charles Ci Wen; Imoto, Nobuyuki; Tamaki, Kiyoshi

    2015-09-09

    In recent years, the gap between theory and practice in quantum key distribution (QKD) has been significantly narrowed, particularly for QKD systems with arbitrarily flawed optical receivers. The status for QKD systems with imperfect light sources is however less satisfactory, in the sense that the resulting secure key rates are often overly dependent on the quality of state preparation. This is especially the case when the channel loss is high. Very recently, to overcome this limitation, Tamaki et al proposed a QKD protocol based on the so-called 'rejected data analysis', and showed that its security in the limit of infinitelymore » long keys is almost independent of any encoding flaw in the qubit space, being this protocol compatible with the decoy state method. Here, as a step towards practical QKD, we show that a similar conclusion is reached in the finite-key regime, even when the intensity of the light source is unstable. More concretely, we derive security bounds for a wide class of realistic light sources and show that the bounds are also efficient in the presence of high channel loss. Our results strongly suggest the feasibility of long distance provably secure communication with imperfect light sources.« less

  9. Aero-thermo-mechanical characteristics of imperfect shape memory alloy hybrid composite panels

    NASA Astrophysics Data System (ADS)

    Ibrahim, Hesham Hamed; Yoo, Hong Hee; Lee, Kwan-Soo

    2009-08-01

    A nonlinear finite element model is provided to predict the static aero-thermal deflection and the vibration behavior of geometrically imperfect shape memory alloy hybrid composite panels under the combined effect of thermal and aerodynamic loads. The nonlinear governing equations are obtained using Marguerre curved plate theory and the principle of virtual work taking into account the temperature-dependence of material properties. The effect of large deflection is included in the formulation through the von Karman nonlinear strain-displacement relations. The thermal load is assumed to be a steady-state constant-temperature distribution, whereas the aerodynamic pressure is modeled using the quasi-steady first-order piston theory. The Newton-Raphson iteration method is employed to obtain the nonlinear aero-thermal deflections, while an eigenvalue problem is solved at each temperature step and static aerodynamic load to predict the free vibration frequencies about the deflected equilibrium position. Finally, the nonlinear deflection and free vibration characteristics of a composite panel are presented, illustrating the effects of geometric imperfection, temperature rise, aerodynamic pressure, boundary conditions and shape memory alloy fiber embeddings on the panel response.

  10. Elastic stability and imperfection sensitivity of axially loaded cylindrical shells on narrow supports

    NASA Astrophysics Data System (ADS)

    Guggenberger, W.

    2006-05-01

    In this paper the elastic stability and imperfection sensitivity of axially loaded cylindrical shells on narrow discrete supports is explored. This is done by parametric geometrically nonlinear finite element analyses of the perfect and imperfect cylinders up to the critical load maxima. In addition, classical buckling eigenvalues are computed for reference purposes. The obtained numerical results are plotted in a systematic unified way and related curve-fit expressions are developed for the critical load maxima in dependency of the geometrical parameters of the problem. The support width, the shell slenderness and the type of local support, i.e. flexible versus rigid local support conditions, are varied. The present basic investigation is restricted to shells with linear-elastic material behaviour. The study of the buckling behaviour for narrow local supports, including the limiting case of point supports is of special concern. Strictly speaking, point supports exist only in the mathematical limit, since the stress singularities which occur in this case are mere artefacts and have no direct physical significance. But it turns out that the local buckling behaviour, like shape and evolution of buckles, magnitude of buckling loads etc. tends to an invariant typical limiting scenario, which is surprising but understandable at the same time. This typical local mono-modal buckling scenario, which is also investigated and presented in this paper, may be viewed as the counterpart to the well-known multi-modal characteristic global buckling scenario which occurs under uniform axial compression.

  11. Detection And Diagnosis Of Ball Bearing Imperfections In Reaction Wheels By Micro-Vibration Test

    NASA Astrophysics Data System (ADS)

    Le, M. P.; van der Heide, E.; Seiler, R.; Cottaar, E. J. E.

    2012-07-01

    The results of micro-vibration test contain information on unbalance level, torque ripples, and most importantly the bearing health status. In this paper, the envelop analysis technique is proposed for localizing imperfections in the bearing. The envelop analysis, which is a powerful method used in ball bearing fault diagnosis, is adapted to the micro-vibration data. This method analyzes the data around the structural resonance: through the amplification of the vibration smaller faults can be detected. The procedure of envelope analysis, its practical issues and robustness are validated with simulated signals. Finally, the envelope analysis is applied to diagnose and evaluate the change in bearing status throughout two environmental tests: sine vibration and full ECSS shock. The result of envelope analysis shows its high sensitivity in revealing the development of small imperfections, makes an initial step in reaction wheel condition monitoring (on-ground and in-flight) and provides insights in design improvement to further lower micro vibration levels of reaction wheels.

  12. The Puzzle of Italian Rice Origin and Evolution: Determining Genetic Divergence and Affinity of Rice Germplasm from Italy and Asia

    PubMed Central

    Jiang, Zhuxi; Basso, Barbara; Sala, Francesco; Spada, Alberto; Grassi, Fabrizio; Lu, Bao-Rong

    2013-01-01

    The characterization of genetic divergence and relationships of a set of germplasm is essential for its efficient applications in crop breeding and understanding of the origin/evolution of crop varieties from a given geographical region. As the largest rice producing country in Europe, Italy holds rice germplasm with abundant genetic diversity. Although Italian rice varieties and the traditional ones in particular have played important roles in rice production and breeding, knowledge concerning the origin and evolution of Italian traditional varieties is still limited. To solve the puzzle of Italian rice origin, we characterized genetic divergence and relationships of 348 rice varieties from Italy and Asia based on the polymorphisms of microsatellite fingerprints. We also included common wild rice O. rufipogon as a reference in the characterization. Results indicated relatively rich genetic diversity (He = 0.63-0.65) in Italian rice varieties. Further analyses revealed a close genetic relationship of the Italian traditional varieties with those from northern China, which provides strong genetic evidence for tracing the possible origin of early established rice varieties in Italy. These findings have significant implications for the rice breeding programs, in which appropriate germplasm can be selected from a given region and utilized for transferring unique genetic traits based on its genetic diversity and evolutionary relationships. PMID:24265814

  13. Knowledge Management

    ERIC Educational Resources Information Center

    Deepak

    2005-01-01

    Knowledge Management (KM) is the process through which organizations generate value from their intellectual and knowledge-based assets. Frequently generating value from such assets means sharing them among employees, divisions and even with other companies in order to develop best practices. This article discusses three basic aspects of…

  14. Knowledge Alive

    ERIC Educational Resources Information Center

    Perkins, David

    2004-01-01

    The strategies that expose learners to the large volume of knowledge, enables them for creative thinking, self-management and deep reading. The different ways of creating knowledge with the help of creativity, communication, organization, problem solving and decision-making are discussed.

  15. Computational Study and Analysis of Structural Imperfections in 1D and 2D Photonic Crystals

    SciTech Connect

    K.R. Maskaly

    2005-06-01

    Dielectric reflectors that are periodic in one or two dimensions, also known as 1D and 2D photonic crystals, have been widely studied for many potential applications due to the presence of wavelength-tunable photonic bandgaps. However, the unique optical behavior of photonic crystals is based on theoretical models of perfect analogues. Little is known about the practical effects of dielectric imperfections on their technologically useful optical properties. In order to address this issue, a finite-difference time-domain (FDTD) code is employed to study the effect of three specific dielectric imperfections in 1D and 2D photonic crystals. The first imperfection investigated is dielectric interfacial roughness in quarter-wave tuned 1D photonic crystals at normal incidence. This study reveals that the reflectivity of some roughened photonic crystal configurations can change up to 50% at the center of the bandgap for RMS roughness values around 20% of the characteristic periodicity of the crystal. However, this reflectivity change can be mitigated by increasing the index contrast and/or the number of bilayers in the crystal. In order to explain these results, the homogenization approximation, which is usually applied to single rough surfaces, is applied to the quarter-wave stacks. The results of the homogenization approximation match the FDTD results extremely well, suggesting that the main role of the roughness features is to grade the refractive index profile of the interfaces in the photonic crystal rather than diffusely scatter the incoming light. This result also implies that the amount of incoherent reflection from the roughened quarterwave stacks is extremely small. This is confirmed through direct extraction of the amount of incoherent power from the FDTD calculations. Further FDTD studies are done on the entire normal incidence bandgap of roughened 1D photonic crystals. These results reveal a narrowing and red-shifting of the normal incidence bandgap with

  16. Hereditary breast cancer: ever more pieces to the polygenic puzzle.

    PubMed

    Bogdanova, Natalia; Helbig, Sonja; Dörk, Thilo

    2013-01-01

    Several susceptibility genes differentially impact on the lifetime risk for breast cancer. Technological advances over the past years have enabled the detection of genetic risk factors through high-throughput screening of large breast cancer case-control series. High- to intermediate penetrance alleles have now been identified in more than 20 genes involved in DNA damage signalling and repair, and more than 70 low-penetrance loci have been discovered through recent genome-wide association studies. In addition to classical germ-line mutation and single-nucleotide polymorphism, copy number variation and somatic mosaicism have been proposed as potential predisposing mechanisms. Many of the identified loci also appear to influence breast tumour characteristics such as estrogen receptor status. In this review, we briefly summarize present knowledge about breast cancer susceptibility genes and discuss their implications for risk prediction and clinical practice. PMID:24025454

  17. Some puzzles about logarithmic relaxations and a few possible resolutions

    SciTech Connect

    Pollak, M.

    2014-08-20

    Three subjects are examined in connection with the relaxation of an electron glass. 1. In most cases the experimental decay time τ is found to relate to a history of the system rather than to the time it takes to reach equilibrium. The reason is that in a non-ergodic system equilibrium cannot be reached in any experiment but the knowledge of an equilibrium property is essential in evaluating the time to reach it. 2. An alternative theory is proposed for the interpretation of aging experiments. The proposed theory is deemed to better represent the physics and is more in keeping with the relaxation theory. 3. A current relaxation theory for the electron glass fails to take into account a certain renewal process during the evolution of the relaxation, namely the possibility of fast transitions following a slow transition. Ramifications of such a neglect are explored.

  18. Hereditary breast cancer: ever more pieces to the polygenic puzzle

    PubMed Central

    2013-01-01

    Several susceptibility genes differentially impact on the lifetime risk for breast cancer. Technological advances over the past years have enabled the detection of genetic risk factors through high-throughput screening of large breast cancer case–control series. High- to intermediate penetrance alleles have now been identified in more than 20 genes involved in DNA damage signalling and repair, and more than 70 low-penetrance loci have been discovered through recent genome-wide association studies. In addition to classical germ-line mutation and single-nucleotide polymorphism, copy number variation and somatic mosaicism have been proposed as potential predisposing mechanisms. Many of the identified loci also appear to influence breast tumour characteristics such as estrogen receptor status. In this review, we briefly summarize present knowledge about breast cancer susceptibility genes and discuss their implications for risk prediction and clinical practice. PMID:24025454

  19. Lower bound for the spatial extent of localized modes in photonic-crystal waveguides with small random imperfections

    NASA Astrophysics Data System (ADS)

    Faggiani, Rémi; Baron, Alexandre; Zang, Xiaorun; Lalouat, Loïc; Schulz, Sebastian A.; O’Regan, Bryan; Vynck, Kevin; Cluzel, Benoît; de Fornel, Frédérique; Krauss, Thomas F.; Lalanne, Philippe

    2016-06-01

    Light localization due to random imperfections in periodic media is paramount in photonics research. The group index is known to be a key parameter for localization near photonic band edges, since small group velocities reinforce light interaction with imperfections. Here, we show that the size of the smallest localized mode that is formed at the band edge of a one-dimensional periodic medium is driven instead by the effective photon mass, i.e. the flatness of the dispersion curve. Our theoretical prediction is supported by numerical simulations, which reveal that photonic-crystal waveguides can exhibit surprisingly small localized modes, much smaller than those observed in Bragg stacks thanks to their larger effective photon mass. This possibility is demonstrated experimentally with a photonic-crystal waveguide fabricated without any intentional disorder, for which near-field measurements allow us to distinctly observe a wavelength-scale localized mode despite the smallness (~1/1000 of a wavelength) of the fabrication imperfections.

  20. Effect of rotation and imperfection on reflection and transmission of plane waves in anisotropic generalized thermoelastic media

    NASA Astrophysics Data System (ADS)

    Kumar, Rajneesh; Singh, Manjeet

    2009-07-01

    The present investigation is concerned with the propagation of plane waves at an imperfectly bonded interface of two orthotropic generalized thermoelastic rotating half-spaces with different elastic and thermal properties. The thermoelastic theory with one relaxation time developed by Lord and Shulman [A generalized dynamical theory of thermoelasticity, J. Mech. Phys. Solids 15 (1967) 299-309] is used to study the problem. The reflection and transmission coefficients of Quasi Longitudinal (QL-) wave, Quasi Thermal (T-mode) wave and Quasi Transverse (QT-) wave have been derived. The effect of rotation has been studied on the velocities of different waves. Some special cases of boundaries i.e. normal stiffness, transverse stiffness, thermal contact conductance, slip boundary and welded contact boundary have been deduced from an imperfect one. Impact of different boundaries has been studied graphically. It is observed that thermal properties, rotation and imperfect boundary have significant effect on the propagation of waves.

  1. Microstructural and crystallographic imperfections of MgB{sub 2} superconducting wire and their correlation with the critical current density

    SciTech Connect

    Shahabuddin, Mohammed; Alzayed, Nasser S.; Oh, Sangjun; Choi, Seyong; Maeda, Minoru; Hata, Satoshi; Shimada, Yusuke; Hossain, Md Shahriar Al; Kim, Jung Ho

    2014-01-15

    A comprehensive study of the effects of structural imperfections in MgB{sub 2} superconducting wire has been conducted. As the sintering temperature becomes lower, the structural imperfections of the MgB{sub 2} material are increased, as reflected by detailed X-ray refinement and the normal state resistivity. The crystalline imperfections, caused by lattice disorder, directly affect the impurity scattering between the π and σ bands of MgB{sub 2}, resulting in a larger upper critical field. In addition, low sintering temperature keeps the grain size small, which leads to a strong enhancement of pinning, and thereby, enhanced critical current density. Owing to both the impurity scattering and the grain boundary pinning, the critical current density, irreversibility field, and upper critical field are enhanced. Residual voids or porosities obviously remain in the MgB{sub 2}, however, even at low sintering temperature, and thus block current transport paths.

  2. Soft Constraints in Interactive Behavior: The Case of Ignoring Perfect Knowledge in-the-World for Imperfect Knowledge in-the-Head

    ERIC Educational Resources Information Center

    Gray, Wayne D.; Fu, Wai-Tat

    2004-01-01

    Constraints and dependencies among the elements of embodied cognition form patterns or microstrategies of interactive behavior. Hard constraints determine which microstrategies are possible. Soft constraints determine which of the possible microstrategies are most likely to be selected. When selection is non-deliberate or automatic the least…

  3. Imperfect asymmetry of life: earth microbial communities prefer D-lactate but can use L-lactate also.

    PubMed

    Moazeni, Faegheh; Zhang, Gaosen; Sun, Henry J

    2010-05-01

    Asymmetrical utilization of chiral compounds has been sought on Mars as evidence for biological activity. This method was recently validated in glucose. Earth organisms utilize D-glucose, not L-glucose, a perfect asymmetry. In this study, we tested the method in lactate and found utilization of both enantiomers. Soil-, sediment-, and lake-borne microbial communities prefer D-lactate but can consume L-lactate if given extra time to acclimate. This situation is termed imperfect asymmetry. Future life-detection mission investigators need to be aware of imperfect asymmetry so as not to miss relatively subtle signs of life. PMID:20528194

  4. Engineering Application Way of Faults Knowledge Discovery Based on Rough Set Theory

    NASA Astrophysics Data System (ADS)

    Rongzhen, Zhao; Chao, Li; Linfeng, Dneg

    2011-07-01

    For the knowledge acquisition puzzle of intelligence decision-making technology in mechanical industry, to use the Rough Set Theory (RST) as a kind of tool to solve the puzzle was researched. And the way to realize the knowledge discovery in engineering application is explored. A case extracting out the knowledge rules from a concise data table shows out some important information. It is that the knowledge discovery similar to the mechanical faults diagnosis is an item of complicated system engineering project. In where, first of all-important tasks is to preserve the faults knowledge into a table with data mode. And the data must be derived from the plant site and should also be as concise as possible. On the basis of the faults knowledge data obtained so, the methods and algorithms to process the data and extract the knowledge rules from them by means of RST can be processed only. The conclusion is that the faults knowledge discovery by the way is a process of rising upward. But to develop the advanced faults diagnosis technology by the way is a large-scale knowledge engineering project for long time. Every step in which should be designed seriously according to the tool's demands firstly. This is the basic guarantees to make the knowledge rules obtained have the values of engineering application and the studies have scientific significance. So, a general framework is designed for engineering application to go along the route developing the faults knowledge discovery technology.

  5. Stochastic modeling of imperfect Salmonella vaccines in an adult dairy herd.

    PubMed

    Lu, Zhao; Gröhn, Yrjö T; Smith, Rebecca L; Karns, Jeffrey S; Hovingh, Ernest; Schukken, Ynte H

    2014-03-01

    Salmonella is a major cause of bacterial foodborne disease. Human salmonellosis results in significant public health concerns and a considerable economic burden. Dairy cattle are recognized as a key source of several Salmonella serovars that are a threat to human health. To lower the risk of Salmonella infection, reduction of Salmonella prevalence in dairy cattle is important. Vaccination as a control measure has been applied for reduction of preharvest Salmonella prevalence on dairy farms. Salmonella vaccines are usually imperfect (i.e., vaccines may provide a partial protection for susceptible animals, reduce the infectiousness and shedding level, shorten the infectious period of infected animals, and/or curb the number of clinical cases), and evaluation of the potential impacts of imperfect Salmonella vaccines at the farm level is valuable to design effective intervention strategies. The objective of this study was to investigate the impact of imperfect Salmonella vaccines on the stochastic transmission dynamics in an adult dairy herd. To this end, we developed a semi-stochastic and individual-based continuous time Markov chain (CTMC) vaccination model with both direct and indirect transmission, and applied the CTMC vaccination model to Salmonella Cerro transmission in an adult dairy herd. Our results show that vaccines shortening the infectious period are most effective in reducing prevalence, and vaccines decreasing host susceptibility are most effective in reducing the outbreak size. Vaccines with multiple moderate efficacies may have the same effectiveness as vaccines with a single high efficacy in reducing prevalence, time to extinction, and outbreak size. Although the environment component has negligible contributions to the prevalence, time to extinction, and outbreak size for Salmonella Cerro in the herd, the relative importance of environment component was not assessed. This study indicates that an effective vaccination program against Salmonella Cerro

  6. Puzzling electron behavior analogous to the Braess paradox in a mesoscopic networ

    NASA Astrophysics Data System (ADS)

    Toussaint, Sébastien; Faniel, Sébastien; Martins, Frederico; Pala, Marco; Desplanque, Ludovic; Wallart, Xavier; Huant, Serge; Sellier, Hermann; Bayot, Vincent; Hackens, Benoit

    A counterintuitive behavior analogous to the Braess paradox is encountered in a two-terminal mesoscopic network patterned in a two-dimensional electron system (2DES). Decreasing locally the electron density of one channel in the network paradoxically leads to an increased network conductance. Our scanning gate microscopy experiments reveals this puzzling conductance variation, thanks to tip-induced localized modifications of electron flow throughout the network's channels at low temperature, in the ballistic and coherent regime of transport. We compare the amplitude of the measured anomalous conductance variation with conductance changes induced by other mechanisms at play in the mesoscopic network, such as interference phenomena between different paths, and Coulomb blockade due to disorder-induced localized states. The robustness of this puzzling behavior is inspected by varying the global 2DES density, magnetic field and temperature S.T. acknowledges support from the Belgian FRS-FNRS (FRIA).

  7. Puzzling electron behavior analogous to the Braess paradox in a mesoscopic network

    NASA Astrophysics Data System (ADS)

    Toussaint, Sébastien; Faniel, Sébastien; Martins, Frederico; Pala, Marco; Desplanque, Ludovic; Wallart, Xavier; Huant, Serge; Sellier, Hermann; Bayot, Vincent; Hackens, Benoit

    A counterintuitive behavior analogous to the Braess paradox is encountered in a two-terminal mesoscopic network patterned in a two-dimensional electron system (2DES). Decreasing locally the electron density of one channel in the network paradoxically leads to an increased network conductance. Our scanning gate microscopy experiments reveals this puzzling conductance variation, thanks to tip-induced localized modifications of electron flow throughout the network's channels at low temperature, in the ballistic and coherent regime of transport. We compare the amplitude of the measured anomalous conductance variation with conductance changes induced by other mechanisms at play in the mesoscopic network, such as interference phenomena between different paths, and Coulomb blockade due to disorder-induced localized states. The robustness of this puzzling behavior is inspected by varying the global 2DES density, magnetic field and temperature. S.T. acknowledges support from the Belgian FRS-FNRS (FRIA).

  8. Applicability, Indispensability, and Underdetermination: Puzzling Over Wigner's `Unreasonable Effectiveness of Mathematics'

    NASA Astrophysics Data System (ADS)

    Gelfert, Axel

    2014-05-01

    In his influential 1960 paper `The Unreasonable Effectiveness of Mathematics in the Natural Sciences', Eugene P. Wigner raises the question of why something that was developed without concern for empirical facts—mathematics—should turn out to be so powerful in explaining facts about the natural world. Recent philosophy of science has developed `Wigner's puzzle' in two different directions: First, in relation to the supposed indispensability of mathematical facts to particular scientific explanations and, secondly, in connection with the idea that aesthetic criteria track theoretical desiderata such as empirical success. An important aspect of Wigner's article has, however, been overlooked in these debates: his worries about the underdetermination of physical theories by mathematical frameworks. The present paper argues that, by restoring this aspect of Wigner's argument to its proper place, Wigner's puzzle may become an instructive case study for the teaching of core issues in the philosophy of science and its history.

  9. (Mis)Perception of Sleep in Insomnia: A puzzle and a resolution

    PubMed Central

    Harvey, Allison G.; Tang, Nicole

    2011-01-01

    Insomnia is prevalent, causing severe distress and impairment. This review focuses on illuminating the puzzling finding that many insomnia patients misperceive their sleep. They overestimate their sleep onset latency (SOL) and underestimate their total sleep time (TST), relative to objective measures. This tendency is ubiquitous (although not universal). Resolving this puzzle has clinical, theoretical, and public health importance. There are implications for assessment, definition, and treatment. Moreover, solving the puzzle creates an opportunity for "real world" applications of theories from clinical, perceptual, and social psychology as well as neuroscience. Herein we evaluate thirteen possible resolutions to the puzzle. Specifically, we consider the possible contribution, to misperception, of: (1) features inherent to the context of sleep (e.g., darkness); (2) the definition of sleep onset which may lack sensitivity for insomnia patients; (3) insomnia being an exaggerated sleep complaint; (4) psychological distress causing magnification; (5) a deficit in time estimation ability; (6) sleep being misperceived as wake; (7) worry and selective attention toward sleep-related threats; (8) a memory bias influenced by current symptoms and emotions, a confirmation bias/belief bias or a recall bias linked to the intensity/recency of symptoms; (9) heightened physiological arousal; (10) elevated cortical arousal; (11) the presence of brief awakenings; (12) a fault in neuronal circuitry; and (13) there being two insomnia subtypes (one with and one without misperception). The best supported resolutions were misperception of sleep as wake, worry, and brief awakenings. A deficit in time estimation ability was not supported. We conclude by proposing several integrative solutions. PMID:21967449

  10. The perimeter generating functions of three-choice, imperfect, and one-punctured staircase polygons

    NASA Astrophysics Data System (ADS)

    Assis, M.; van Hoeij, M.; Maillard, J.-M.

    2016-05-01

    We consider the isotropic perimeter generating functions of three-choice, imperfect, and one-punctured staircase polygons, whose 8th order linear Fuchsian ODEs are previously known. We derive simple relationships between the three generating functions, and show that all three generating functions are joint solutions of a common 12th order Fuchsian linear ODE. We find that the 8th order differential operators can each be rewritten as a direct sum of a direct product, with operators no larger than 3rd order. We give closed-form expressions for all the solutions of these operators in terms of 2 F 1 hypergeometric functions with rational and algebraic arguments. The solutions of these linear differential operators can in fact be expressed in terms of two modular forms, since these 2 F 1 hypergeometric functions can be expressed with two, rational or algebraic, pullbacks. Dedicated to A J Guttmann on the occasion of his 70th birthday.

  11. Diffraction and Imaging Study of Imperfections of Protein Crystals with Coherent X-rays

    NASA Technical Reports Server (NTRS)

    Hu, Z. W.; Thomas, B. R.; Chernov, A. A.; Chu, Y. S.; Lai, B.

    2004-01-01

    High angular-resolution x-ray diffraction and phase contrast x-ray imaging were combined to study defects and perfection of protein crystals. Imperfections including line defects, inclusions and other microdefects were observed in the diffraction images of a uniformly grown lysozyme crystal. The observed line defects carry distinct dislocation features running approximately along the <110> growth front and have been found to originate mostly in a central growth area and occasionally in outer growth regions. Slow dehydration led to the broadening of a fairly symmetric 4 4 0 rocking curve by a factor of approximately 2.6, which was primarily attributed to the dehydration-induced microscopic effects that are clearly shown in diffraction images. X-ray imaging and diffraction characterization of the quality of apoferritin crystals will also be discussed in the presentation.

  12. Arrival times and temporal moments of breakthrough curves for an imperfectly stratified aquifer

    USGS Publications Warehouse

    Naff, R.L.

    1992-01-01

    A solution in Laplace transform space is obtained for transport of resident concentration in an imperfectly but yet highly stratified porous medium. From this transform-space solution either temporal moments can be derived by taking derivatives with respect to the Laplace parameter, or the transform-space solution can be inverted numerically to obtain breakthrough curves for the mean concentration. When compared to an equivalent solution with a Fickian dispersive flux, these temporal moments indicate the extent to which transport in heterogeneous porous media deviates from classifical Fickian behaviour. The numerical inversion of the Laplace transform solution gives partial breakthrough curves for the mean concentration which have the appearance of conflicting with the derived moment information. A hypothesis is put forth which resolves this apparent conflict; this hypothesis is verified by adding a component of local dispersion to the governing transport equation. -from Author

  13. Modal interactions in primary and subharmonic resonant dynamics of imperfect microplates with geometric nonlinearities

    NASA Astrophysics Data System (ADS)

    Farokhi, Hamed; Ghayesh, Mergen H.

    2016-06-01

    This paper analyses the modal interactions in the nonlinear, size-dependent dynamics of geometrically imperfect microplates. Based on the modified couple stress theory, the equations of motion for the in-plane and out-of-plane motions are obtained employing the von Kármán plate theory as well as Kirchhoff's hypotheses by means of the Lagrange equations. The equations of motions are solved using the pseudo-arclength continuation technique and direct time-integration method. The system parameters are tuned to the values associated with modal interactions, and then nonlinear resonant responses and energy transfer are analysed. Nonlinear motion characteristics are shown in the form of frequency-response and force-response curves, time histories, phase-plane portraits, and fast Fourier transforms.

  14. Ability of stabilizer quantum error correction to protect itself from its own imperfection

    NASA Astrophysics Data System (ADS)

    Fujiwara, Yuichiro

    2014-12-01

    The theory of stabilizer quantum error correction allows us to actively stabilize quantum states and simulate ideal quantum operations in a noisy environment. It is critical to correctly diagnose noise from its syndrome and nullify it accordingly. However, hardware that performs quantum error correction itself is inevitably imperfect in practice. Here, we show that stabilizer codes possess a built-in capability to correct errors not only on quantum information but also on faulty syndromes extracted by themselves. Shor's syndrome extraction for fault-tolerant quantum computation is naturally improved. This opens a path to realizing the potential of stabilizer quantum error correction hidden within an innocent-looking choice of generators and stabilizer operators that have been deemed redundant.

  15. On the role of interface imperfections in thermoelectric nondestructive materials characterization

    NASA Astrophysics Data System (ADS)

    Hu, Jiangtao; Nagy, Peter B.

    1998-07-01

    This letter draws attention to a previously unnoticed artifact associated with the most common type of thermoelectric nondestructive materials characterization technique. It is shown that contact heating between the specimen to be tested and the reference electrode gives rise to a considerable offset in the measured thermoelectric voltage. The resulting bias significantly reduces the feasibility of thermoelectric measurements in nondestructive testing applications that require sensitive materials discrimination, for example, to sort metals of similar alloying content, to distinguish similar grades of heat treatment, and to detect slight variations in the thermoelectric power of metals due to hardening, texture, fatigue, etc. It is also suggested that the demonstrated intrinsic sensitivity of the thermoelectric contact technique to imperfect interfaces could be exploited for nondestructive detection of tightly compressed but metallurgically not bonded interfaces in spot welds, diffusion bonds, and other types of solid-state bonds.

  16. A multiple-scales model of the shock-cell structure of imperfectly expanded supersonic jets

    NASA Technical Reports Server (NTRS)

    Tam, C. K. W.; Jackson, J. A.; Seiner, J. M.

    1985-01-01

    The present investigation is concerned with the development of an analytical model of the quasi-periodic shock-cell structure of an imperfectly expanded supersonic jet. The investigation represents a part of a program to develop a mathematical theory of broadband shock-associated noise of supersonic jets. Tam and Tanna (1982) have suggested that this type of noise is generated by the weak interaction between the quasi-periodic shock cells and the downstream-propagating large turbulence structures in the mixing layer of the jet. In the model developed in this paper, the effect of turbulence in the mixing layer of the jet is simulated by the addition of turbulent eddy-viscosity terms to the momentum equation. Attention is given to the mean-flow profile and the numerical solution, and a comparison of the numerical results with experimental data.

  17. Some Classes of Imperfect Information Finite State-Space Stochastic Games with Finite-Dimensional Solutions

    SciTech Connect

    McEneaney, William M.

    2004-08-15

    Stochastic games under imperfect information are typically computationally intractable even in the discrete-time/discrete-state case considered here. We consider a problem where one player has perfect information.A function of a conditional probability distribution is proposed as an information state.In the problem form here, the payoff is only a function of the terminal state of the system,and the initial information state is either linear ora sum of max-plus delta functions.When the initial information state belongs to these classes, its propagation is finite-dimensional.The state feedback value function is also finite-dimensional,and obtained via dynamic programming,but has a nonstandard form due to the necessity of an expanded state variable.Under a saddle point assumption,Certainty Equivalence is obtained and the proposed function is indeed an information state.

  18. Intraocular Ossification in the GSP/pe Chicken With Imperfect Albinism.

    PubMed

    Shibuya, K; Kinoshita, K; Mizutani, M; Oshima, A; Yamashita, R; Matsuda, Y

    2015-07-01

    The eyes of 2 male and 2 female GSP/pe chickens, the imperfect albino strain, were investigated at 52 weeks of age. Aged chickens of the GSP/pe colony became blind with bilateral ocular enlargement and opaque lenses. Affected eyes (bilateral in 2 males and unilateral in 2 females) were hard and difficult to section; histologic specimens were processed after decalcification. A large portion of the posterior chamber was occupied by cancellous bone containing fibrous and cartilaginous foci. Osseous tissues developed adjacent to the choroid, and no retinal pigment epithelium (RPE) was detected between osseous tissues and the choroid. Small segments of degenerate neuronal retina were scattered in the osseous tissue. The irises and ciliary bodies were deformed by osseous tissue, and the lenses had severe cataracts. These observations suggest that the intraocular osseous tissue may be derived from RPE in the hereditary incomplete-albino strain of chickens. PMID:25421422

  19. Modal interactions in primary and subharmonic resonant dynamics of imperfect microplates with geometric nonlinearities

    NASA Astrophysics Data System (ADS)

    Farokhi, Hamed; Ghayesh, Mergen H.

    2015-12-01

    This paper analyses the modal interactions in the nonlinear, size-dependent dynamics of geometrically imperfect microplates. Based on the modified couple stress theory, the equations of motion for the in-plane and out-of-plane motions are obtained employing the von Kármán plate theory as well as Kirchhoff's hypotheses by means of the Lagrange equations. The equations of motions are solved using the pseudo-arclength continuation technique and direct time-integration method. The system parameters are tuned to the values associated with modal interactions, and then nonlinear resonant responses and energy transfer are analysed. Nonlinear motion characteristics are shown in the form of frequency-response and force-response curves, time histories, phase-plane portraits, and fast Fourier transforms.

  20. Signal processing for the detection of multiple imperfection echoes drowned in the structural noise.

    PubMed

    Drai, R; Benammar, A; Benchaala, A

    2004-04-01

    In this work, we propose to develop algorithms based on the split spectrum processing method associated with the multi-steps method based on "Group delay moving entropy" (GDME) allowing detecting and locating multiple imperfection echoes drowned in the structural noise of materials. In fact, GDME is based on the fact that defect echoes have a constant group delay while the noise has a random group delay. The investigation is performed with 4 known defect echoes with different characteristics (position, center frequency and bandwidth). The defect echo frequency is varied around the frequency of the input signal in order to evaluate, by signal to noise ratio calculation, the robustness of the detection method. The grain noise signal is generated first, by a simple clutter model which consider the noise, in the time domain, as the superimposed of signal coming from backscaterers in the medium and second, experimentally by a material with coarse grains. PMID:15047392

  1. (Investigations of ultrasonic wave interactions with grain boundaries and grain imperfections)

    SciTech Connect

    Not Available

    1990-01-01

    The main objective of our research is to obtain a better understanding of ultrasonic wave interaction with interfaces in polycrystalline materials. This report discusses two recently developed experimental techniques: scanning acoustic microscope and optical point sensors. As for general wave propagation problems in anisotropic media, four major topics are discussed in separate sections. First, single boundaries between large bicrystals are considered. The reflection and transmission coefficients of such interfaces are calculated for imperfect boundary conditions by using the finite interface stiffness approach. Ultrasonic transmission through multiple-grain structures are investigated by computer simulation based on the statistical evaluation of repeated acoustical wave interactions with individual grain boundaries. The number of grains interacting with the propagating acoustical wave is considered to be high enough to approximate the wave-material interaction as scattering on elastic inhomogeneities. The grain scattering induced attenuation of Rayleigh waves is investigated in polycrystalline materials. 41 refs., 43 figs.

  2. Ignoring imperfect detection in biological surveys is dangerous: a response to 'fitting and interpreting occupancy models'.

    PubMed

    Guillera-Arroita, Gurutzeta; Lahoz-Monfort, José J; MacKenzie, Darryl I; Wintle, Brendan A; McCarthy, Michael A

    2014-01-01

    In a recent paper, Welsh, Lindenmayer and Donnelly (WLD) question the usefulness of models that estimate species occupancy while accounting for detectability. WLD claim that these models are difficult to fit and argue that disregarding detectability can be better than trying to adjust for it. We think that this conclusion and subsequent recommendations are not well founded and may negatively impact the quality of statistical inference in ecology and related management decisions. Here we respond to WLD's claims, evaluating in detail their arguments, using simulations and/or theory to support our points. In particular, WLD argue that both disregarding and accounting for imperfect detection lead to the same estimator performance regardless of sample size when detectability is a function of abundance. We show that this, the key result of their paper, only holds for cases of extreme heterogeneity like the single scenario they considered. Our results illustrate the dangers of disregarding imperfect detection. When ignored, occupancy and detection are confounded: the same naïve occupancy estimates can be obtained for very different true levels of occupancy so the size of the bias is unknowable. Hierarchical occupancy models separate occupancy and detection, and imprecise estimates simply indicate that more data are required for robust inference about the system in question. As for any statistical method, when underlying assumptions of simple hierarchical models are violated, their reliability is reduced. Resorting in those instances where hierarchical occupancy models do no perform well to the naïve occupancy estimator does not provide a satisfactory solution. The aim should instead be to achieve better estimation, by minimizing the effect of these issues during design, data collection and analysis, ensuring that the right amount of data is collected and model assumptions are met, considering model extensions where appropriate. PMID:25075615

  3. Acoustic resonance scattering from a multilayered cylindrical shell with imperfect bonding.

    PubMed

    Rajabi, M; Hasheminejad, Seyyed M

    2009-12-01

    The method of wave function expansion is adopted to study the three dimensional scattering of a time-harmonic plane progressive sound field obliquely incident upon a multi-layered hollow cylinder with interlaminar bonding imperfection. For the generality of solution, each layer is assumed to be cylindrically orthotropic. An approximate laminate model in the context of the modal state equations with variable coefficients along with the classical T-matrix solution technique is set up for each layer to solve for the unknown modal scattering and transmission coefficients. A linear spring model is used to describe the interlaminar adhesive bonding whose effects are incorporated into the global transfer matrix by introduction of proper interfacial transfer matrices. Following the classic acoustic resonance scattering theory (RST), the scattered field and response to surface waves are determined by constructing the partial waves and obtaining the non-resonance (backgrounds) and resonance components. The solution is first used to investigate the effect of interlayer imperfection of an air-filled and water submerged bilaminate aluminium cylindrical shell on the resonances associated with various modes of wave propagation (i.e., symmetric/asymmetric Lamb waves, fluid-borne A-type waves, Rayleigh and Whispering Gallery waves) appearing in the backscattered spectrum, according to their polarization and state of stress. An illustrative numerical example is also given for a multi-layered (five-layered) cylindrical shell for which the stiffness of the adhesive interlayers is artificially varied. The sensitivity of resonance frequencies associated with higher mode numbers to the stiffness coefficients is demonstrated to be a good measure of the bonding strength. Limiting cases are considered and fair agreements with solutions available in the literature are established. PMID:19586650

  4. Correction of small imperfections on white glazed china surfaces by laser radiation

    NASA Astrophysics Data System (ADS)

    Képíró, I.; Osvay, K.; Divall, M.

    2007-07-01

    A laser-assisted technique has been developed for correction of small diameter (1 mm) and shallow (0.5 mm) imperfections on the surface of gloss fired porcelain. To study the physics and establish the important parameters, artificially made holes in a porcelain sample have been first filled with correction material, then covered with raw glaze and treated by a pulsed, 7 kHz repetition rate CO 2 laser at 10.6 μm. The modification of the surface and the surrounding area have been quantified and studied with a large range of parameters of incident laser power (1-10 W), width of the laser pulses (10-125 μs) and duration of laser heating (60-480 s). Although the shine of the treated area, defined as the distribution of micro-droplets on the surface, is very similar to the untreated surfaces, the surroundings of the treated area usually show cracks. The measurement of both the spatial temperature distribution and the temporal cooling rate of the treated surface has revealed that a simple melting process always results in high gradient temperature distribution within the irradiated zone. Its inhomogeneous and fast cooling always generate at least micro-cracks on the surface within a few seconds after the laser was turned off. The duration and intensity of the laser irradiation have been then optimized in order to achieve the fastest possible melting of the surface, but without producing such high temperature gradients. To eliminate the cracks, more elaborated pre-heating and slowed-cooling-rate processes have been tried with prosperous results. These achievements complete our previous study, making possible to repair the most common surface imperfections and holes of gloss fired china samples.

  5. Loss reduction in few-mode photonic crystal fiber by reducing inner surface imperfections in air holes.

    PubMed

    Ma, Lin; Hanzawa, Nobutomo; Tsujikawa, Kyozo; Aozasa, Shinichi; Yamamoto, Fumihiko

    2015-05-18

    We studied both theoretically and experimentally the additional loss in photonic crystal fiber (PCF) that results from inner surface imperfections such as contamination and the surface roughness of air holes. We estimated the modal loss dependence of these imperfections using a model with a "defective layer" for the first time. The theoretical studies suggest that higher order modes have a larger loss due to imperfections in the air holes. By minimizing the inner surface imperfections of the six innermost air holes, we can theoretically expect any additional loss to be reduced to a negligible level. Moreover, we examined our theoretical prediction experimentally. We fabricated few-mode PCFs by employing a suitable inner surface treatment for just the six innermost holes. As expected theoretically, the transmission loss was greatly reduced by employing these processes. The lowest transmission losses in the 1550 nm band were 0.31 dB/km for the LP01 mode and 0.43 dB/km for the LP11 mode. Our theoretical model will be useful with a view to realizing few-mode PCF with a loss comparable to that of conventional fibers. PMID:26074611

  6. Competence Similarities between Native and Near-Native Speakers: An Investigation of the Preterite-Imperfect Contrast in Spanish

    ERIC Educational Resources Information Center

    Montrul, Silvina; Slabakova, Roumyana

    2003-01-01

    It has been suggested that tense and aspect distributions are very difficult to learn in a second language (L2), they are prone to fossilize universally, and their interpretive properties are subject to a critical period (Coppieters, 1987). This study focuses on the acquisition of the semantic implications of the preterite-imperfect contrast in…

  7. From Theory to Practice: A Path through Imperfection--Lessons from Evaluation of Policy Oriented Environmental Health Research in Belgium

    ERIC Educational Resources Information Center

    Keune, Hans; Morrens, Bert; Loots, Ilse; Springael, Johan

    2011-01-01

    Background: Dealing with complex issues per definition bears the burden of imperfection. Whatever comforting theoretical concepts may promise, real life complexity will take its messy toll once travelling from conceptual ambition to real life practice. We specifically reflect on the social scientific contribution to these inter- and…

  8. Consequences of CCD Imperfections for Cosmology Determined by Weak Lensing Surveys: From Laboratory Measurements to Cosmological Parameter Bias

    NASA Astrophysics Data System (ADS)

    Okura, Yuki; Petri, Andrea; May, Morgan; Plazas, Andrés A.; Tamagawa, Toru

    2016-07-01

    Weak gravitational lensing causes subtle changes in the apparent shapes of galaxies due to the bending of light by the gravity of foreground masses. By measuring the shapes of large numbers of galaxies (millions in recent surveys, up to tens of billions in future surveys) we can infer the parameters that determine cosmology. Imperfections in the detectors used to record images of the sky can introduce changes in the apparent shapes of galaxies, which in turn can bias the inferred cosmological parameters. In this paper we consider the effect of two widely discussed sensor imperfections: tree rings, due to impurity gradients that cause transverse electric fields in the charge-coupled devices (CCDs), and pixel size variation, due to periodic CCD fabrication errors. These imperfections can be observed when the detectors are subject to uniform illumination (flat-field images). We develop methods to determine the spurious shear and convergence (due to the imperfections) from the flat-field images. We calculate how the spurious shear when added to the lensing shear will bias the determination of cosmological parameters. We apply our methods to candidate sensors of the Large Synoptic Survey Telescope (LSST) as a timely and important example, analyzing flat-field images recorded with LSST prototype CCDs in the laboratory. We find that tree rings and periodic pixel size variation present in the LSST CCDs will introduce negligible bias to cosmological parameters determined from the lensing power spectrum, specifically w, {{{Ω }}}m, and {σ }8.

  9. Acquisition of the Korean Imperfective Aspect Markers "-ko iss-" and "-a iss-" by Japanese Learners: A Multiple-Factor Account

    ERIC Educational Resources Information Center

    Ryu, Ju-Yeon; Horie, Kaoru; Shirai, Yasuhiro

    2015-01-01

    Although cross-linguistic research on second language tense-aspect acquisition has uncovered universal tendencies concerning the association between verbal semantics and tense-aspect markers, it is still unclear what mechanisms underlie this link. This study investigates the acquisition of two imperfective aspect markers ("-ko iss-" and…

  10. Procedural knowledge

    NASA Technical Reports Server (NTRS)

    Georgeff, Michael P.; Lansky, Amy L.

    1986-01-01

    Much of commonsense knowledge about the real world is in the form of procedures or sequences of actions for achieving particular goals. In this paper, a formalism is presented for representing such knowledge using the notion of process. A declarative semantics for the representation is given, which allows a user to state facts about the effects of doing things in the problem domain of interest. An operational semantics is also provided, which shows how this knowledge can be used to achieve particular goals or to form intentions regarding their achievement. Given both semantics, the formalism additionally serves as an executable specification language suitable for constructing complex systems. A system based on this formalism is described, and examples involving control of an autonomous robot and fault diagnosis for NASA's Space Shuttle are provided.

  11. Working Knowledge.

    ERIC Educational Resources Information Center

    Beckett, David

    The resurgence of "lifelong learning" has renewed consideration of the nature of "working knowledge." Lifelong learning has many aspects, including construction and distribution of individuals' very self-hood, educational institutions' role in capturing informal experiences, and the juggling required between family and work-based responsibilities.…

  12. Precision astronomy with imperfect fully depleted CCDs — an introduction and a suggested lexicon

    NASA Astrophysics Data System (ADS)

    Stubbs, C. W.

    2014-03-01

    This paper summarizes the introductory presentation for a workshop (held Nov 18, 19 2013 at Brookhaven National Laboratory) that explored the challenges associated with making precision astronomical measurements using deeply depleted = ``thick" =``high-ρ'' CCDs. While thick CCDs do provide definite advantages in terms of increased quantum efficiency at wavelengths 700 nm < λ < 1.1 μm and reduced fringing from atmospheric emission lines, these devices also exhibit undesirable features that pose a challenge to precision determination of the positions, fluxes, and shapes of astronomical objects, and for the precision extraction of features in astronomical spectra. For example, the assumptions of a perfectly rectilinear pixel grid and of an intensity-independent point spread function become increasingly invalid as we push to higher precision measurements. Many of the effects seen in these devices arise from lateral electrical fields within the detector, that produce charge transport anomalies that have been previously misinterpreted as quantum efficiency variations. Performing simplistic flat-fielding therefore introduces systematic errors in the image processing pipeline. One measurement challenge we face is devising a combination of calibration methods and algorithms that can distinguish genuine quantum efficiency variations from charge transport effects. These device imperfections also confront spectroscopic applications, such as line centroid determination for precision radial velocity studies. Given the scientific benefits of improving both the precision and accuracy of astronomical measurements, we need to identify, characterize, and overcome these various detector artifacts. In retrospect, many of the detector features first identified in thick CCDs also afflict measurements made with more traditional CCD detectors, albeit often at a reduced level since the photocharge is subject to the perturbing influence of lateral electric fields for a shorter time

  13. Characterization of weld imperfections in 2195 Al-Li alloy: Experimental approaches towards mechanisms

    NASA Astrophysics Data System (ADS)

    Zaidi, Anwer Arif

    1997-10-01

    2195 Al-Li alloy apparently offers significantly higher strength to weight ratio than the 2219 aluminum alloy. It was discovered that 2195 Al-Li has a greater tendency to crack, generates peculiar kind of porosity, and is vulnerable to deleterious microparticulate emission during welding than its 2219 predecessor. An experimental investigation has been carried to characterize these weld imperfections in 2195 Al-Li alloy. This work presents a scientific account of an analytical study and of the clues it has provided towards an understanding of the weld imperfections in 2195 Al-Li welds. The study begins with the observation of peculiar pore formation in 2195 welds, which occurs not as in the case of 2219 welds upon solidification, but in a thermal ageing process subsequent to solidification. An apparent reaction (DTA) between the fusion zone dendritic surface and nitrogen gas implies a porous fusion zone. Tiny surface melting sites, designated as Blisters, due to its resemblance to skin blisters, testify to the conjunction of outgassing and melting effects and suggest that porosity formation in the solid phase depends upon local melting as well as outgassing. The absence of a dark magnesium rich substance, designated as smut in the immediate vicinity of a crack opening next to a weld repair bead implies either an umbrella of gas emission keeping off a condensate evaporated under the welding arc or, possibly an expulsion of atomized, liquified metal from the crack itself in the form of microparticulate emission. These microparticulate emission from VPPA welds takes various forms herein labeled as smut, snow, and Lava. It is attributed to a gas generating reaction taking place at molten grain boundaries or crack surfaces. The reaction could only be release of hydrogen displaced from lithium hydrides by a coming influx of dissolved nitrogen. There appears to be a close link between porosity, cracking and microparticulate emission. Observations of melting on the surface

  14. An Interactive 3D Virtual Anatomy Puzzle for Learning and Simulation - Initial Demonstration and Evaluation.

    PubMed

    Messier, Erik; Wilcox, Jascha; Dawson-Elli, Alexander; Diaz, Gabriel; Linte, Cristian A

    2016-01-01

    To inspire young students (grades 6-12) to become medical practitioners and biomedical engineers, it is necessary to expose them to key concepts of the field in a way that is both exciting and informative. Recent advances in medical image acquisition, manipulation, processing, visualization, and display have revolutionized the approach in which the human body and internal anatomy can be seen and studied. It is now possible to collect 3D, 4D, and 5D medical images of patient specific data, and display that data to the end user using consumer level 3D stereoscopic display technology. Despite such advancements, traditional 2D modes of content presentation such as textbooks and slides are still the standard didactic equipment used to teach young students anatomy. More sophisticated methods of display can help to elucidate the complex 3D relationships between structures that are so often missed when viewing only 2D media, and can instill in students an appreciation for the interconnection between medicine and technology. Here we describe the design, implementation, and preliminary evaluation of a 3D virtual anatomy puzzle dedicated to helping users learn the anatomy of various organs and systems by manipulating 3D virtual data. The puzzle currently comprises several components of the human anatomy and can be easily extended to include additional organs and systems. The 3D virtual anatomy puzzle game was implemented and piloted using three display paradigms - a traditional 2D monitor, a 3D TV with active shutter glass, and the DK2 version Oculus Rift, as well as two different user interaction devices - a space mouse and traditional keyboard controls. PMID:27046584

  15. A 17 keV neutrino and large magnetic moment solution of the solar neutrino puzzle

    NASA Astrophysics Data System (ADS)

    Akhmedov, E. Kh.; Senjanovic, G.; Tao, Zhijian; Berezhiani, Z. G.

    1992-08-01

    Zee-type models with Majorons naturally incorporate the 17 keV neutrino but in their minimal version fail to simultaneously solve the solar neutrino puzzle. If there is a sterile neutrino state, a particularly simple solution is found to the solar neutrino problem, which besides nu(sub 17) predicts a light Zeldovich-Konopinski-Mahmoud neutrino nu(sub light) = nu(sub e) + nu(sub mu)(sup c) with a magnetic moment being easily as large as 10(exp -11)(mu)(sub B) through the Barr-Freire-Zee mechanism.

  16. 17 keV neutrino and large magnetic moment solution of the solar neutrino puzzle

    NASA Astrophysics Data System (ADS)

    Akhmedov, Eugeni Kh.; Berezhiani, Zurab G.; Senjanović, Goran; Tao, Zhijian

    1993-01-01

    Zee-type models with majorons naturally incorporate the 17 keV neutrino but in their minimal version fail to simultaneously solve the solar neutrino puzzle. If there is a sterile neutrino state, we find a particularly simple solution to the solar neutrino problem, which besides ν17 predicts a light Zeldovich-Konopinski-Mahmoud neutrino νlight = νe + νcμ with a magnetic moment being easily as large as 10 -11μB through the Barr-Freire-Zee mechanism.

  17. Sirtuin Activation: A Role for Plasma Membrane in the Cell Growth Puzzle

    PubMed Central

    2013-01-01

    For more than 20 years, the observation that impermeable oxidants can stimulate cell growth has not been satisfactorily explained. The discovery of sirtuins provides a logical answer to the puzzle. The NADH-dependent transplasma membrane electron transport system, which is stimulated by growth factors and interventions such as calorie restriction, can transfer electrons to external acceptors and protect against stress-induced apoptosis. We hypothesize that the activation of plasma membrane electron transport contributes to the cytosolic NAD+ pool required for sirtuin to activate transcription factors necessary for cell growth and survival. PMID:23033342

  18. The puzzle of the steady-state rotation of a reverse sprinkler

    NASA Astrophysics Data System (ADS)

    Rueckner, Wolfgang

    2015-04-01

    The continuous rotation of the reverse sprinkler has been a puzzle for over two decades. This article presents a series of experiments that demonstrate that a properly designed reverse sprinkler experiences no steady-state torque and does not rotate. Ignoring transients when the flow starts and stops, if any sustained rotation of the reverse sprinkler occurs, it is because a force couple produces a torque accompanied by vortex flow inside the body of the sprinkler. No steady-state rotation occurs if the vortex is suppressed or prevented from forming in the first place. Demonstrative proof is given that an ideal reverse sprinkler does not rotate.

  19. Goal anticipation during action observation is influenced by synonymous action capabilities, a puzzling developmental study.

    PubMed

    Gredebäck, Gustaf; Kochukhova, Olga

    2010-04-01

    Eighteen- and 25-month-old human toddlers' ability to manually solve a puzzle and their ability to anticipate the goal during observation of similar actions were investigated. Results demonstrate that goal anticipation during action observation is dependent on manual ability, both on a group level (only 25-month-olds solved the manual task and anticipated the goal during observation) and individually within the older age group (r (xy) = 0.53). These findings suggests a connection between manual ability and the ability to anticipate the goal of others' actions in toddlers, in accordance with the direct matching hypothesis. PMID:20041233

  20. The resolution of an entropy puzzle for 4D non-BPS black holes

    NASA Astrophysics Data System (ADS)

    Banerjee, Nabamita; Bansal, Sukruti; Lodato, Ivano

    2016-05-01

    We show the equality between macroscopic and microscopic (statistical) black hole entropy for a class of four dimensional non-supersymmetric black holes in mathcal{N} = 2 supergravity theory, up to the first subleading order in their charges. This solves a long standing entropy puzzle for this class of black holes. The macroscopic entropy has been computed in the presence of a newly derived higher-derivative supersymmetric invariant of [1], connected to the five dimensional supersymmetric Weyl squared Lagrangian. Microscopically, the crucial role in obtaining the equivalence is played by the anomalous gauge gravitational Chern-Simons term.

  1. Challenges in Acute Heart Failure Clinical Management: Optimizing Care Despite Incomplete Evidence and Imperfect Drugs

    PubMed Central

    Maisel, Alan S.; Storrow, Alan B.

    2015-01-01

    Acute heart failure is a common condition associated with considerable morbidity, mortality, and cost. However, evidence-based data on treating heart failure in the acute setting are limited, and current individual treatment options have variable efficacy. The healthcare team must often individualize patient care in ways that may extend beyond available clinical guidelines. In this review, we address the question, “How do you do the best you can clinically with incomplete evidence and imperfect drugs?” Expert opinion is provided to supplement guideline-based recommendations and help address the typical challenges that are involved in the management of patients with acute heart failure. Specifically, we discuss 4 key areas that are important in the continuum of patient care: differential diagnosis and risk stratification; choice and implementation of initial therapy; assessment of the adequacy of therapy during hospitalization or observation; and considerations for discharge/transition of care. A case study is presented to highlight the decision-making process throughout each of these areas. Evidence is accumulating that should help guide patients and healthcare providers on a path to better quality of care. PMID:25679083

  2. Boundary-layer receptivity due to distributed surface imperfections of a deterministic or random nature

    NASA Technical Reports Server (NTRS)

    Choudhari, Meelan

    1992-01-01

    Acoustic receptivity of a Blasius boundary layer in the presence of distributed surface irregularities is investigated analytically. It is shown that, out of the entire spatial spectrum of the surface irregularities, only a small band of Fourier components can lead to an efficient conversion of the acoustic input at any given frequency to an unstable eigenmode of the boundary layer flow. The location, and width, of this most receptive band of wavenumbers corresponds to a relative detuning of O(R sub l.b.(exp -3/8)) with respect to the lower-neutral instability wavenumber at the frequency under consideration, R sub l.b. being the Reynolds number based on a typical boundary-layer thickness at the lower branch of the neutral stability curve. Surface imperfections in the form of discrete mode waviness in this range of wavenumbers lead to initial instability amplitudes which are O(R sub l.b.(exp 3/8)) larger than those caused by a single, isolated roughness element. In contrast, irregularities with a continuous spatial spectrum produce much smaller instability amplitudes, even compared to the isolated case, since the increase due to the resonant nature of the response is more than that compensated for by the asymptotically small band-width of the receptivity process. Analytical expressions for the maximum possible instability amplitudes, as well as their expectation for an ensemble of statistically irregular surfaces with random phase distributions, are also presented.

  3. Online and Social Media Data As an Imperfect Continuous Panel Survey

    PubMed Central

    2016-01-01

    There is a large body of research on utilizing online activity as a survey of political opinion to predict real world election outcomes. There is considerably less work, however, on using this data to understand topic-specific interest and opinion amongst the general population and specific demographic subgroups, as currently measured by relatively expensive surveys. Here we investigate this possibility by studying a full census of all Twitter activity during the 2012 election cycle along with the comprehensive search history of a large panel of Internet users during the same period, highlighting the challenges in interpreting online and social media activity as the results of a survey. As noted in existing work, the online population is a non-representative sample of the offline world (e.g., the U.S. voting population). We extend this work to show how demographic skew and user participation is non-stationary and difficult to predict over time. In addition, the nature of user contributions varies substantially around important events. Furthermore, we note subtle problems in mapping what people are sharing or consuming online to specific sentiment or opinion measures around a particular topic. We provide a framework, built around considering this data as an imperfect continuous panel survey, for addressing these issues so that meaningful insight about public interest and opinion can be reliably extracted from online and social media data. PMID:26730933

  4. Effect of bow-type initial imperfection on reliability of minimum-weight, stiffened structural panels

    NASA Technical Reports Server (NTRS)

    Stroud, W. Jefferson; Krishnamurthy, Thiagaraja; Sykes, Nancy P.; Elishakoff, Isaac

    1993-01-01

    Computations were performed to determine the effect of an overall bow-type imperfection on the reliability of structural panels under combined compression and shear loadings. A panel's reliability is the probability that it will perform the intended function - in this case, carry a given load without buckling or exceeding in-plane strain allowables. For a panel loaded in compression, a small initial bow can cause large bending stresses that reduce both the buckling load and the load at which strain allowables are exceeded; hence, the bow reduces the reliability of the panel. In this report, analytical studies on two stiffened panels quantified that effect. The bow is in the shape of a half-sine wave along the length of the panel. The size e of the bow at panel midlength is taken to be the single random variable. Several probability density distributions for e are examined to determine the sensitivity of the reliability to details of the bow statistics. In addition, the effects of quality control are explored with truncated distributions.

  5. Imperfect placebos are common in low back pain trials: a systematic review of the literature

    PubMed Central

    Kamper, S. J.; Herbert, R. D.; Maher, C. G.; McAuley, J. H.

    2008-01-01

    The placebo is an important tool to blind patients to treatment allocation and therefore minimise some sources of bias in clinical trials. However, placebos that are improperly designed or implemented may introduce bias into trials. The purpose of this systematic review was to evaluate the adequacy of placebo interventions used in low back pain trials. Electronic databases were searched systematically for randomised placebo-controlled trials of conservative interventions for low back pain. Trial selection and data extraction were performed by two reviewers independently. A total of 126 trials using over 25 different placebo interventions were included. The strategy most commonly used to enhance blinding was the provision of structurally equivalent placebos. Adequacy of blinding was assessed in only 13% of trials. In 20% of trials the placebo intervention was a potentially genuine treatment. Most trials that assessed patients’ expectations showed that the placebo generated lower expectations than the experimental intervention. Taken together, these results demonstrate that imperfect placebos are common in low back pain trials; a result suggesting that many trials provide potentially biased estimates of treatment efficacy. This finding has implications for the interpretation of published trials and the design of future trials. Implementation of strategies to facilitate blinding and balance expectations in randomised groups need a higher priority in low back pain research. Electronic supplementary material The online version of this article (doi:10.1007/s00586-008-0664-3) contains supplementary material, which is available to authorized users. PMID:18421484

  6. Microstructural design of biopolymer blends and related elasticity with imperfect interfacial bonding.

    PubMed

    Belhabib, Sofiane; Guessasma, Sofiane; Haddadi, Halim

    2016-03-15

    The underlined microstructure of biopolymer blends reflects complexity of mass and heat transfer during processing. In the present work, such complexity is apprehended using simple and intuitive way to generate typical microstructures resulting from thermomoulding processing. The starting point is a simple generation scheme of the feed powder approximated as circular heat sources. Finite element computation of a transient thermal analysis is performed and the resulting nodal fields are again converted into 2D microstructures. The final microstructures prove to be similar in all geometrical characteristics starch-zein blends. Elasticity response of these blends is explored using finite element computation. Sensitivity analysis is performed to derive the effect of perfect and imperfect interface properties on the mechanical performance of the biopolymer blend. Predictions show a significant role of interfaces which trigger the elasticity properties of the biopolymer blends much larger than the contrast in phase properties. This study demonstrates that nonlinear interface effect on elasticity behaviour is related to geometrical percolation that occurs at specific phase content. PMID:26794767

  7. Imperfect pseudo-merohedral twinning in crystals of fungal fatty acid synthase

    PubMed Central

    Jenni, Simon; Ban, Nenad

    2009-01-01

    The recent high-resolution structures of fungal fatty acid synthase (FAS) have provided new insights into the principles of fatty acid biosynthesis by large multifunctional enzymes. The crystallographic phase problem for the 2.6 MDa fungal FAS was initially solved to 5 Å resolution using two crystal forms from Thermomyces lanuginosus. Monoclinic crystals in space group P21 were obtained from orthorhombic crystals in space group P212121 by dehydration. Here, it is shown how this space-group transition induced imperfect pseudo-merohedral twinning in the monoclinic crystal, giving rise to a Moiré pattern-like interference of the two twin-related reciprocal lattices. The strategy for processing the twinned diffraction images and obtaining a quantitative analysis is presented. The twinning is also related to the packing of the molecules in the two crystal forms, which was derived from self-rotation function analysis and molecular-replacement solutions using a low-resolution electron microscopy map as a search model. PMID:19171964

  8. Improving inferences in population studies of rare species that are detected imperfectly

    USGS Publications Warehouse

    MacKenzie, D.I.; Nichols, J.D.; Sutton, N.; Kawanishi, K.; Bailey, L.L.

    2005-01-01

    For the vast majority of cases, it is highly unlikely that all the individuals of a population will be encountered during a study. Furthermore, it is unlikely that a constant fraction of the population is encountered over times, locations, or species to be compared. Hence, simple counts usually will not be good indices of population size. We recommend that detection probabilities (the probability of including an individual in a count) be estimated and incorporated into inference procedures. However, most techniques for estimating detection probability require moderate sample sizes, which may not be achievable when studying rare species. In order to improve the reliability of inferences from studies of rare species, we suggest two general approaches that researchers may wish to consider that incorporate the concept of imperfect detectability: (1) borrowing information about detectability or the other quantities of interest from other times, places, or species; and (2) using state variables other than abundance (e.g., species richness and occupancy). We illustrate these suggestions with examples and discuss the relative benefits and drawbacks of each approach.

  9. Imperfect in-vehicle collision avoidance warning systems can aid drivers.

    PubMed

    Maltz, Masha; Shinar, David

    2004-01-01

    An experiment was conducted to determine the effects of an in-vehicle collision avoidance warning system (IVCAWS) on driver performance. A driving simulator was driven by 135 licensed drivers. Of these, 120 received alerts from the IVCAWS when their headway to a lead car was less than 2 s, and the other 15 (the control group) received no alerts. Drivers received varied alert interfaces: auditory, visual, and multimodal. The system had varied levels of reliability, determined by both false alarm rate and failure of the IVCAWS to alert to short headway. Results indicated that the IVCAWS led to safer (longer) headway maintenance. High false alarm rates induced drivers to slow down unnecessarily; large numbers of missed alerts did not have any significant impact on drivers. Driver acceptance of the system was mixed. Interface played a role in driver reliance on the system, with the multimodal interfaces generating least reliance. Actual or potential applications of this research include IVCAWS interface selection for greater system efficacy and user acceptance and the advisability of implementation, even of imperfect systems, for drivers who seek to maintain a safer headway. PMID:15359683

  10. Spatial Heterogeneity and Imperfect Mixing in Chemical Reactions: Visualization of Density-Driven Pattern Formation

    DOE PAGESBeta

    Sobel, Sabrina G.; Hastings, Harold M.; Testa, Matthew

    2009-01-01

    Imore » mperfect mixing is a concern in industrial processes, everyday processes (mixing paint, bread machines), and in understanding salt water-fresh water mixing in ecosystems. The effects of imperfect mixing become evident in the unstirred ferroin-catalyzed Belousov-Zhabotinsky reaction, the prototype for chemical pattern formation. Over time, waves of oxidation (high ferriin concentration, blue) propagate into a background of low ferriin concentration (red); their structure reflects in part the history of mixing in the reaction vessel. However, it may be difficult to separate mixing effects from reaction effects. We describe a simpler model system for visualizing density-driven pattern formation in an essentially unmixed chemical system: the reaction of pale yellow Fe 3 + with colorless SCN − to form the blood-red Fe ( SCN ) 2 + complex ion in aqueous solution. Careful addition of one drop of Fe ( NO 3 ) 3 to KSCN yields striped patterns after several minutes. The patterns appear reminiscent of Rayleigh-Taylor instabilities and convection rolls, arguing that pattern formation is caused by density-driven mixing.« less

  11. Quantum sine-Gordon dynamics on analogue curved spacetime in a weakly imperfect scalar Bose gas

    NASA Astrophysics Data System (ADS)

    Volkoff, T. J.; Fischer, Uwe R.

    2016-07-01

    Using the coherent state functional integral expression of the partition function, we show that the sine-Gordon model on an analogue curved spacetime arises as the effective quantum field theory for phase fluctuations of a weakly imperfect Bose gas on an incompressible background superfluid flow when these fluctuations are restricted to a subspace of the single-particle Hilbert space. We consider bipartitions of the single-particle Hilbert space relevant to experiments on ultracold bosonic atomic or molecular gases, including, e.g., restriction to high- or low-energy sectors of the dynamics and spatial bipartition corresponding to tunnel-coupled planar Bose gases. By assuming full unitary quantum control in the low-energy subspace of a trapped gas, we show that (1) appropriately tuning the particle number statistics of the lowest-energy mode partially decouples the low- and high-energy sectors, allowing any low-energy single-particle wave function to define a background for sine-Gordon dynamics on curved spacetime and (2) macroscopic occupation of a quantum superposition of two states of the lowest two modes produces an analogue curved spacetime depending on two background flows, with respective weights continuously dependent on the corresponding weights of the superposed quantum states.

  12. Testing hypotheses in evolutionary ecology with imperfect detection: capture-recapture structural equation modeling.

    PubMed

    Cubaynes, Sarah; Doutrelant, Claire; Grégoire, Arnaud; Perret, Philippe; Faivre, Bruno; Gimenez, Olivier

    2012-02-01

    Studying evolutionary mechanisms in natural populations often requires testing multifactorial scenarios of causality involving direct and indirect relationships among individual and environmental variables. It is also essential to account for the imperfect detection of individuals to provide unbiased demographic parameter estimates. To cope with these issues, we developed a new approach combining structural equation models with capture-recapture models (CR-SEM) that allows the investigation of competing hypotheses about individual and environmental variability observed in demographic parameters. We employ Markov chain Monte Carlo sampling in a Bayesian framework to (1) estimate model parameters, (2) implement a model selection procedure to evaluate competing hypotheses about causal mechanisms, and (3) assess the fit of models to data using posterior predictive checks. We illustrate the value of our approach using two case studies on wild bird populations. We first show that CR-SEM can be useful to quantify the action of selection on a set of phenotypic traits with an analysis of selection gradients on morphological traits in Common Blackbirds (Turdus merula). In a second case study on Blue Tits (Cyanistes caeruleus), we illustrate the use of CR-SEM to study evolutionary trade-offs in the wild, while accounting for varying environmental conditions. PMID:22624306

  13. Entanglement-assisted quantum error-correcting codes with imperfect ebits

    NASA Astrophysics Data System (ADS)

    Lai, Ching-Yi; Brun, Todd A.

    2012-09-01

    The scheme of entanglement-assisted quantum error-correcting (EAQEC) codes assumes that the ebits of the receiver are error free. In practical situations, errors on these ebits are unavoidable, which diminishes the error-correcting ability of these codes. We consider two different versions of this problem. We first show that any (nondegenerate) standard stabilizer code can be transformed into an EAQEC code that can correct errors on the qubits of both sender and receiver. These EAQEC codes are equivalent to standard stabilizer codes, and hence the decoding techniques of standard stabilizer codes can be applied. Several EAQEC codes of this type are found to be optimal. In a second scheme, the receiver uses a standard stabilizer code to protect the ebits, which we call a “combination code.” The performances of different quantum codes are compared in terms of the channel fidelity over the depolarizing channel. We give a formula for the channel fidelity over the depolarizing channel (or any Pauli error channel), and show that it can be efficiently approximated by a Monte Carlo calculation. Finally, we discuss the tradeoff between performing extra entanglement distillation and applying an EAQEC code with imperfect ebits.

  14. Culling Dogs in Scenarios of Imperfect Control: Realistic Impact on the Prevalence of Canine Visceral Leishmaniasis

    PubMed Central

    Costa, Danielle N. C. C.; Codeço, Cláudia T.; Silva, Moacyr A.; Werneck, Guilherme L.

    2013-01-01

    Background Visceral leishmaniasis belongs to the list of neglected tropical diseases and is considered a public health problem worldwide. Spatial correlation between the occurrence of the disease in humans and high rates of canine infection suggests that in the presence of the vector, canine visceral leishmaniasis is the key factor for triggering transmission to humans. Despite the control strategies implemented, such as the sacrifice of infected dogs being put down, the incidence of American visceral leishmaniasis remains high in many Latin American countries. Methodology/Principal Findings Mathematical models were developed to describe the transmission dynamics of canine leishmaniasis and its control by culling. Using these models, imperfect control scenarios were implemented to verify the possible factors which alter the effectiveness of controlling this disease in practice. Conclusions/Significance A long-term continuous program targeting both asymptomatic and symptomatic dogs should be effective in controlling canine leishmaniasis in areas of low to moderate transmission (R0 up to 1.4). However, the indiscriminate sacrifice of asymptomatic dogs with positive diagnosis may jeopardize the effectiveness of the control program, if tests with low specificity are used, increasing the chance of generating outrage in the population, and leading to lower adherence to the program. Therefore, culling must be planned accurately and implemented responsibly and never as a mechanical measure in large scale. In areas with higher transmission, culling alone is not an effective control strategy. PMID:23951375

  15. Fault-tolerant system analysis: imperfect switching and maintenance. Final technical paper

    SciTech Connect

    Veatch, M.H.; Foley, R.D.

    1987-01-01

    This final report presents the results of research into two important areas of concern for fault-tolerant avionics systems: testability analysis and innovative repair policies. The algorithms developed from this research have been included in the Mission Reliability Model (MIREM) and verified by comparison with known results from several Integrated Communication, Navigation, and Identification Avionics architectures. The purpose of the testability analysis was to develop techniques for assessing the impact of imperfect switching on the overall reliability of fault-tolerant avionics. A method of quantifying the effects of undetected errors and false alarms has been developed and included in MIREM. Under the next phase of the program, three repair statistics were identified: Mean Time To Repair, Mean Time Between Maintenance Actions, and Inherent Availability. These were used to define four alternative repair policies: immediate repair, deferred repair, scheduled maintenance, and repair at degraded level. Also included in MIREM as model outputs, these four options offer greater flexibility in evaluating and developing avionics designs.

  16. Imperfect Batesian mimicry—the effects of the frequency and the distastefulness of the model

    PubMed Central

    Lindström, L.; Alatalo, R. V.; Mappes, J.

    1997-01-01

    Batesian mimicry is the resemblance between unpalatable models and palatable mimics. The widely accepted idea is that the frequency and the unprofitability of the model are crucial for the introduction of a Batesian mimic into the prey population. However, experimental evidence is limited and furthermore, previous studies have considered mainly perfect mimicry (automimicry). We investigated imperfect Batesian mimicry by varying the frequency of an aposematic model at two levels of distastefulness. The predator encountered prey in a random order, one prey item at a time. The prey were thus presented realistically in a sequential way. Great tits (Parus major) were used as predators. This experiment, with a novel signal, supports the idea that Batesian mimics gain most when the models outnumber them. The mortalities of the mimics as well as the models were significantly dependent on the frequency of the model. Both prey types survived better the fewer mimics there were confusing the predator. There were also indications that the degree of distastefulness of the model had an effect on the survival of the Batesian mimic: the models survived significantly better the more distasteful they were. The experiment supports the most classical predictions in the theories of the origin and maintenance of Batesian mimicry.

  17. Reflection and refraction at an imperfectly bonded interface between poroelastic solid and cracked elastic solid

    NASA Astrophysics Data System (ADS)

    Nandal, J. S.; Saini, T. N.

    2013-04-01

    Porous solid is in contact with a cracked elastic solid at a plane interface between them. For the presence of vertically aligned microcracks, the elastic solid behaves transversely isotropic to wave propagation. The coefficients of elastic anisotropy depend on the crack density and crack porosity in the medium. A loose bonding is considered between the two solids so that a limiting case could be the welded contact. At the plane interface, the imperfection in welded bonding is represented by tangential slipping and, hence, results in the dissipation of a part of strain energy. Three types of waves propagate in an isotropic fluid-saturated porous medium, which are considered for incidence at the interface. Incidence of a wave results in three reflected waves and two refracted waves. Partition of incident energy among the reflected and refracted waves is studied for each incidence, varying from normal to grazing directions. Numerical example calculates the energy shares of reflected and refracted waves at the plane interface between water-saturated sandstone and basalt. These energy shares are computed and analyzed for different values of crack parameters as well as loose bonding parameter.

  18. Novel mutational mechanism in the thyroglobulin gene: imperfect DNA inversion as a cause for hereditary hypothyroidism.

    PubMed

    Citterio, Cintia E; Rossetti, Liliana C; Souchon, Pierre F; Morales, Cecilia; Thouvard-Viprey, Mathilde; Salmon-Musial, Anne S; Mauran, Pierre L A; Doco-Fenzy, Martine; González-Sarmiento, Rogelio; Rivolta, Carina M; De Brasi, Carlos D; Targovnik, Héctor M

    2013-12-01

    The objective of this study was to perform genetic analysis in three brothers of Turkish origin born from consanguineus parents and affected by congenital hypothyroidism, goiter and low levels of serum TG. The combination of sequencing of DNA, PCR mapping, quantitative real-time PCR, inverse-PCR (I-PCR), multiplex PCR and bioinformatics analysis were used in order to detect TG mutations. We demonstrated that the three affected siblings are homozygous for a DNA inversion of 16,962bp in the TG gene associated with two deleted regions at both sides of the inversion limits. The inversion region includes the first 9bp of exon 48, 1015bp of intron 47, 191bp of exon 47, 1523bp of intron 46, 135bp of exon 46 and the last 14,089bp of intron 45. The proximal deletion corresponds to 27bp of TG intron 45, while the distal deletion spans the last 230bp of TG exon 48 and the first 588bp of intergenic region downstream TG end. The parents were heterozygous carriers of the complex rearrangement. In conclusion, a novel large imperfect DNA inversion within the TG gene was identified by the strategy of I-PCR. This aberration was not detectable by normal sequencing of the exons and exon/intron boundaries. Remarkably, the finding represents the first description of a TG deficiency disease caused by a DNA inversion. PMID:23933148

  19. Online and Social Media Data As an Imperfect Continuous Panel Survey.

    PubMed

    Diaz, Fernando; Gamon, Michael; Hofman, Jake M; Kıcıman, Emre; Rothschild, David

    2016-01-01

    There is a large body of research on utilizing online activity as a survey of political opinion to predict real world election outcomes. There is considerably less work, however, on using this data to understand topic-specific interest and opinion amongst the general population and specific demographic subgroups, as currently measured by relatively expensive surveys. Here we investigate this possibility by studying a full census of all Twitter activity during the 2012 election cycle along with the comprehensive search history of a large panel of Internet users during the same period, highlighting the challenges in interpreting online and social media activity as the results of a survey. As noted in existing work, the online population is a non-representative sample of the offline world (e.g., the U.S. voting population). We extend this work to show how demographic skew and user participation is non-stationary and difficult to predict over time. In addition, the nature of user contributions varies substantially around important events. Furthermore, we note subtle problems in mapping what people are sharing or consuming online to specific sentiment or opinion measures around a particular topic. We provide a framework, built around considering this data as an imperfect continuous panel survey, for addressing these issues so that meaningful insight about public interest and opinion can be reliably extracted from online and social media data. PMID:26730933

  20. Imperfect physician assistant and physical therapist admissions processes in the United States

    PubMed Central

    2014-01-01

    We compared and contrasted physician assistant and physical therapy profession admissions processes based on the similar number of accredited programs in the United States and the co-existence of many programs in the same school of health professions, because both professions conduct similar centralized application procedures administered by the same organization. Many studies are critical of the fallibility and inadequate scientific rigor of the high-stakes nature of health professions admissions decisions, yet typical admission processes remain very similar. Cognitive variables, most notably undergraduate grade point averages, have been shown to be the best predictors of academic achievement in the health professions. The variability of non-cognitive attributes assessed and the methods used to measure them have come under increasing scrutiny in the literature. The variance in health professions students’ performance in the classroom and on certifying examinations remains unexplained, and cognitive considerations vary considerably between and among programs that describe them. One uncertainty resulting from this review is whether or not desired candidate attributes highly sought after by individual programs are more student-centered or graduate-centered. Based on the findings from the literature, we suggest that student success in the classroom versus the clinic is based on a different set of variables. Given the range of positions and general lack of reliability and validity in studies of non-cognitive admissions attributes, we think that health professions admissions processes remain imperfect works in progress. PMID:24810020

  1. The Origin of Aging: Imperfectness-Driven Non-Random Damage Defines the Aging Process and Control of Lifespan

    PubMed Central

    Gladyshev, Vadim N.

    2013-01-01

    Physico-chemical properties preclude ideal biomolecules and perfect biological functions. This inherent imperfectness leads to the generation of damage by every biological process, at all levels, from small molecules to cells. The damage is too numerous to be repaired, is partially invisible to natural selection and manifests as aging. I propose that it is the inherent imperfectness of biological systems that is the true root of the aging process. As each biomolecule generates specific forms of damage, the cumulative damage is largely non-random and is indirectly encoded in the genome. I consider this concept in light of other proposed theories of aging and integrate these disparate ideas into a single model. I also discuss the evolutionary significance of damage accumulation and strategies for reducing damage. Finally, I suggest ways to test this integrated model of aging. PMID:23769208

  2. Consequences of CCD imperfections for cosmology determined by weak lensing surveys: from laboratory measurements to cosmological parameter bias

    DOE PAGESBeta

    Okura, Yuki; Petri, Andrea; May, Morgan; Plazas, Andrés A.; Tamagawa, Toru

    2016-06-27

    Weak gravitational lensing causes subtle changes in the apparent shapes of galaxies due to the bending of light by the gravity of foreground masses. By measuring the shapes of large numbers of galaxies (millions in recent surveys, up to tens of billions in future surveys) we can infer the parameters that determine cosmology. Imperfections in the detectors used to record images of the sky can introduce changes in the apparent shape of galaxies, which in turn can bias the inferred cosmological parameters. Here in this paper we consider the effect of two widely discussed sensor imperfections: tree-rings, due to impuritymore » gradients which cause transverse electric fields in the Charge-Coupled Devices (CCD), and pixel-size variation, due to periodic CCD fabrication errors. These imperfections can be observed when the detectors are subject to uniform illumination (flat field images). We develop methods to determine the spurious shear and convergence (due to the imperfections) from the flat-field images. We calculate how the spurious shear when added to the lensing shear will bias the determination of cosmological parameters. We apply our methods to candidate sensors of the Large Synoptic Survey Telescope (LSST) as a timely and important example, analyzing flat field images recorded with LSST prototype CCDs in the laboratory. In conclusion, we find that tree-rings and periodic pixel-size variation present in the LSST CCDs will introduce negligible bias to cosmological parameters determined from the lensing power spectrum, specifically w,Ωm and σ8.« less

  3. Heralded single-photon generation using imperfect single-photon sources and a two-photon-absorbing medium

    SciTech Connect

    Konrad, Thomas; Scherer, Artur; Nock, Michael; Audretsch, Juergen

    2006-03-15

    We propose a setup for a heralded, i.e., announced generation of a pure single-photon state given two imperfect sources whose outputs are represented by mixtures of the single-photon Fock state [1> with the vacuum [0>. Our purification scheme uses beam splitters, photodetection, and a two-photon-absorbing medium. The admixture of the vacuum is fully eliminated. We discuss two potential realizations of the scheme.

  4. A Hybrid alldifferent-Tabu Search Algorithm for Solving Sudoku Puzzles.

    PubMed

    Soto, Ricardo; Crawford, Broderick; Galleguillos, Cristian; Paredes, Fernando; Norero, Enrique

    2015-01-01

    The Sudoku problem is a well-known logic-based puzzle of combinatorial number-placement. It consists in filling a n(2) × n(2) grid, composed of n columns, n rows, and n subgrids, each one containing distinct integers from 1 to n(2). Such a puzzle belongs to the NP-complete collection of problems, to which there exist diverse exact and approximate methods able to solve it. In this paper, we propose a new hybrid algorithm that smartly combines a classic tabu search procedure with the alldifferent global constraint from the constraint programming world. The alldifferent constraint is known to be efficient for domain filtering in the presence of constraints that must be pairwise different, which are exactly the kind of constraints that Sudokus own. This ability clearly alleviates the work of the tabu search, resulting in a faster and more robust approach for solving Sudokus. We illustrate interesting experimental results where our proposed algorithm outperforms the best results previously reported by hybrids and approximate methods. PMID:26078751

  5. Heavy flavor puzzle at LHC: a serendipitous interplay of jet suppression and fragmentation.

    PubMed

    Djordjevic, Magdalena

    2014-01-31

    Both charged hadrons and D mesons are considered to be excellent probes of QCD matter created in ultrarelativistic heavy ion collisions. Surprisingly, recent experimental observations at LHC show the same jet suppression for these two probes, which--contrary to pQCD expectations--may suggest similar energy losses for light quarks and gluons in the QCD medium. We here use our recently developed energy loss formalism in a finite-size dynamical QCD medium to analyze this phenomenon that we denote as the "heavy flavor puzzle at LHC." We show that this puzzle is a consequence of an unusual combination of the suppression and fragmentation patterns and, in fact, does not require invoking the same energy loss for light partons. Furthermore, we show that this combination leads to a simple relationship between the suppressions of charged hadrons and D mesons and the corresponding bare quark suppressions. Consequently, a coincidental matching of jet suppression and fragmentation allows considerably simplifying the interpretation of the corresponding experimental data. PMID:24580442

  6. Eta Carinae: A Box of Puzzles...Some Solved, Others Await

    NASA Technical Reports Server (NTRS)

    Gull, Theodore

    2010-01-01

    In the l840's, Eta Carinae brightened to rival Sirius, then faded. Today we see a marginally naked-eye binary with an expanding, very dusty bipolar Homunculus. The energetics of the ejected mass (>l2 to 40 solar masses at 500-700 km/s plus outer bullets/strings up to 3000 km/s} approach that of a supernova. Extragalactic SN surveys detect near-supernovae thought to be like the Great Eruption of the 1840's. Eta Carinae presents an abundance of puzzles: rich in N, but 1/100th the solar C and O abundances; Ti, V, Sr, Sc persist in atomic states.... yet an abundance of molecules and dust exists in the Homunculus. How did molecules and dust form with low C and O? A near supernova occurred in the l840m, yet both binary companions, with total mass > 120 solar masses, survive in a very eccentric orbit. What is the near future of this system: a GRB? a SN? or just two WR stars that ultimately become two SNs? These and other puzzles will be presented

  7. A Hybrid alldifferent-Tabu Search Algorithm for Solving Sudoku Puzzles

    PubMed Central

    Crawford, Broderick; Paredes, Fernando; Norero, Enrique

    2015-01-01

    The Sudoku problem is a well-known logic-based puzzle of combinatorial number-placement. It consists in filling a n2 × n2 grid, composed of n columns, n rows, and n subgrids, each one containing distinct integers from 1 to n2. Such a puzzle belongs to the NP-complete collection of problems, to which there exist diverse exact and approximate methods able to solve it. In this paper, we propose a new hybrid algorithm that smartly combines a classic tabu search procedure with the alldifferent global constraint from the constraint programming world. The alldifferent constraint is known to be efficient for domain filtering in the presence of constraints that must be pairwise different, which are exactly the kind of constraints that Sudokus own. This ability clearly alleviates the work of the tabu search, resulting in a faster and more robust approach for solving Sudokus. We illustrate interesting experimental results where our proposed algorithm outperforms the best results previously reported by hybrids and approximate methods. PMID:26078751

  8. Effect of imperfect detectability on adaptive and conventional sampling: simulated sampling of freshwater mussels in the upper Mississippi River.

    PubMed

    Smith, David R; Gray, Brian R; Newton, Teresa J; Nichols, Doug

    2010-11-01

    Adaptive sampling designs are recommended where, as is typical with freshwater mussels, the outcome of interest is rare and clustered. However, the performance of adaptive designs has not been investigated when outcomes are not only rare and clustered but also imperfectly detected. We address this combination of challenges using data simulated to mimic properties of freshwater mussels from a reach of the upper Mississippi River. Simulations were conducted under a range of sample sizes and detection probabilities. Under perfect detection, efficiency of the adaptive sampling design increased relative to the conventional design as sample size increased and as density decreased. Also, the probability of sampling occupied habitat was four times higher for adaptive than conventional sampling of the lowest density population examined. However, imperfect detection resulted in substantial biases in sample means and variances under both adaptive sampling and conventional designs. The efficiency of adaptive sampling declined with decreasing detectability. Also, the probability of encountering an occupied unit during adaptive sampling, relative to conventional sampling declined with decreasing detectability. Thus, the potential gains in the application of adaptive sampling to rare and clustered populations relative to conventional sampling are reduced when detection is imperfect. The results highlight the need to increase or estimate detection to improve performance of conventional and adaptive sampling designs. PMID:19946742

  9. Lower bound for the spatial extent of localized modes in photonic-crystal waveguides with small random imperfections.

    PubMed

    Faggiani, Rémi; Baron, Alexandre; Zang, Xiaorun; Lalouat, Loïc; Schulz, Sebastian A; O'Regan, Bryan; Vynck, Kevin; Cluzel, Benoît; de Fornel, Frédérique; Krauss, Thomas F; Lalanne, Philippe

    2016-01-01

    Light localization due to random imperfections in periodic media is paramount in photonics research. The group index is known to be a key parameter for localization near photonic band edges, since small group velocities reinforce light interaction with imperfections. Here, we show that the size of the smallest localized mode that is formed at the band edge of a one-dimensional periodic medium is driven instead by the effective photon mass, i.e. the flatness of the dispersion curve. Our theoretical prediction is supported by numerical simulations, which reveal that photonic-crystal waveguides can exhibit surprisingly small localized modes, much smaller than those observed in Bragg stacks thanks to their larger effective photon mass. This possibility is demonstrated experimentally with a photonic-crystal waveguide fabricated without any intentional disorder, for which near-field measurements allow us to distinctly observe a wavelength-scale localized mode despite the smallness (~1/1000 of a wavelength) of the fabrication imperfections. PMID:27246902

  10. Effect of imperfect detectability on adaptive and conventional sampling: Simulated sampling of freshwater mussels in the upper Mississippi River

    USGS Publications Warehouse

    Smith, D.R.; Gray, B.R.; Newton, T.J.; Nichols, D.

    2010-01-01

    Adaptive sampling designs are recommended where, as is typical with freshwater mussels, the outcome of interest is rare and clustered. However, the performance of adaptive designs has not been investigated when outcomes are not only rare and clustered but also imperfectly detected. We address this combination of challenges using data simulated to mimic properties of freshwater mussels from a reach of the upper Mississippi River. Simulations were conducted under a range of sample sizes and detection probabilities. Under perfect detection, efficiency of the adaptive sampling design increased relative to the conventional design as sample size increased and as density decreased. Also, the probability of sampling occupied habitat was four times higher for adaptive than conventional sampling of the lowest density population examined. However, imperfect detection resulted in substantial biases in sample means and variances under both adaptive sampling and conventional designs. The efficiency of adaptive sampling declined with decreasing detectability. Also, the probability of encountering an occupied unit during adaptive sampling, relative to conventional sampling declined with decreasing detectability. Thus, the potential gains in the application of adaptive sampling to rare and clustered populations relative to conventional sampling are reduced when detection is imperfect. The results highlight the need to increase or estimate detection to improve performance of conventional and adaptive sampling designs.

  11. Lower bound for the spatial extent of localized modes in photonic-crystal waveguides with small random imperfections

    PubMed Central

    Faggiani, Rémi; Baron, Alexandre; Zang, Xiaorun; Lalouat, Loïc; Schulz, Sebastian A.; O’Regan, Bryan; Vynck, Kevin; Cluzel, Benoît; de Fornel, Frédérique; Krauss, Thomas F.; Lalanne, Philippe

    2016-01-01

    Light localization due to random imperfections in periodic media is paramount in photonics research. The group index is known to be a key parameter for localization near photonic band edges, since small group velocities reinforce light interaction with imperfections. Here, we show that the size of the smallest localized mode that is formed at the band edge of a one-dimensional periodic medium is driven instead by the effective photon mass, i.e. the flatness of the dispersion curve. Our theoretical prediction is supported by numerical simulations, which reveal that photonic-crystal waveguides can exhibit surprisingly small localized modes, much smaller than those observed in Bragg stacks thanks to their larger effective photon mass. This possibility is demonstrated experimentally with a photonic-crystal waveguide fabricated without any intentional disorder, for which near-field measurements allow us to distinctly observe a wavelength-scale localized mode despite the smallness (~1/1000 of a wavelength) of the fabrication imperfections. PMID:27246902

  12. Maximum likelihood estimation of label imperfection probabilities and its use in the identification of mislabeled patterns. [with application to Landsat MSS data processing

    NASA Technical Reports Server (NTRS)

    Chittineni, C. B.

    1980-01-01

    Estimating label imperfections and the use of estimations in the identification of mislabeled patterns are discussed. Expressions are presented for the asymptotic variances of the probability of correct classification and proportion, and for the maximum likelihood estimates of classification errors and a priori probabilities. Models are developed for imperfections in the labels and classification errors, and expressions are derived for the probability of imperfect label identification schemes resulting in wrong decisions. The expressions are used in computing thresholds and the techniques are given practical applications. The imperfect label identification scheme in the multiclass case is found to amount to establishing a region around each decision surface, and decisions of the label correction scheme are found in close agreement with the analyst-interpreter interpretations of the imagery films. As an example, the application of the maximum likelihood estimation to the processing of Landsat MSS data is discussed.

  13. Some issues in resolution of diagnostic tests using an imperfect gold standard.

    PubMed

    Hawkins, D M; Garrett, J A; Stephenson, B

    2001-07-15

    As a subject's true disease status is seldom known with certainty, it is necessary to compare the performance of new diagnostic tests with those of a currently accepted but imperfect 'gold standard'. Errors made by the gold standard mean that the sensitivity and specificity calculated for the new test are biased, and do not correctly estimate the new method's sensitivity and specificity. The traditional approach to this problem was 'discrepant resolution', in which the subjects for whom the two methods disagreed were subjected to a third 'resolver' test. Recent work has pointed out that this does not automatically solve the problem. A sounder approach goes beyond the discordant test results and tests at least some of the subjects with concordant results with the resolver also. This leaves some issues unresolved. One is the basic question of the direction of biases in various estimators. We point out that this question does not have a simple universal answer. Another issue, if one is to test a sample of the subjects with concordant results rather than all cases, is how to compute estimates and standard errors of the measures of test performance, notably sensitivity and specificity of the test method relative to the resolver. Expressions for these standard errors are given and illustrated with a numeric example. It is shown that using just a sample of subjects with concordant results may lead to great savings in assays. The design issue of how many concordant cells to test depends on the numbers of concordants and discordants. The formulae given show how to evaluate impact of different choices for these numbers and hence settle on a design that gives the required precision of estimates. PMID:11427955

  14. A novel method for studying the buckling of nanotubes considering geometrical imperfections

    NASA Astrophysics Data System (ADS)

    Anoop Krishnan, N. M.; Ghosh, Debraj

    2014-05-01

    Buckling of nanotubes has been studied using many methods such as molecular dynamics (MD), molecular mechanics, and continuum-based shell theories. In MD, motion of the individual atoms is tracked under applied temperature and pressure, ensuring a reliable estimate of the material response. The response thus simulated varies for individual nanotubes and is only as accurate as the force field used to model the atomic interactions. On the other hand, there exists a rich literature on the understanding of continuum mechanics-based shell theories. Based on the observations on the behavior of nanotubes, there have been a number of shell theory-based approaches to study the buckling of nanotubes. Although some of these methods yield a reasonable estimate of the buckling stress, investigation and comparison of buckled mode shapes obtained from continuum analysis and MD are sparse. Previous studies show that the direct application of shell theories to study nanotube buckling often leads to erroneous results. The present study reveals that a major source of this error can be attributed to the departure of the shape of the nanotube from a perfect cylindrical shell. Analogous to the shell buckling in the macro-scale, in this work, the nanotube is modeled as a thin-shell with initial imperfection. Then, a nonlinear buckling analysis is carried out using the Riks method. It is observed that this proposed approach yields significantly improved estimate of the buckling stress and mode shapes. It is also shown that the present method can account for the variation of buckling stress as a function of the temperature considered. Hence, this can prove to be a robust method for a continuum analysis of nanosystems taking in the effect of variation of temperature as well.

  15. Transitions between imperfectly ordered crystalline structures: A phase switch Monte Carlo study

    NASA Astrophysics Data System (ADS)

    Wilms, Dorothea; Wilding, Nigel B.; Binder, Kurt

    2012-05-01

    A model for two-dimensional colloids confined laterally by “structured boundaries” (i.e., ones that impose a periodicity along the slit) is studied by Monte Carlo simulations. When the distance D between the confining walls is reduced at constant particle number from an initial value D0, for which a crystalline structure commensurate with the imposed periodicity fits, to smaller values, a succession of phase transitions to imperfectly ordered structures occur. These structures have a reduced number of rows parallel to the boundaries (from n to n-1 to n-2, etc.) and are accompanied by an almost periodic strain pattern, due to “soliton staircases” along the boundaries. Since standard simulation studies of such transitions are hampered by huge hysteresis effects, we apply the phase switch Monte Carlo method to estimate the free energy difference between the structures as a function of the misfit between D and D0, thereby locating where the transitions occur in equilibrium. For comparison, we also obtain this free energy difference from a thermodynamic integration method: The results agree, but the effort required to obtain the same accuracy as provided by phase switch Monte Carlo would be at least three orders of magnitude larger. We also show for a situation where several “candidate structures” exist for a phase, that phase switch Monte Carlo can clearly distinguish the metastable structures from the stable one. Finally, applying the method in the conjugate statistical ensemble (where the normal pressure conjugate to D is taken as an independent control variable), we show that the standard equivalence between the conjugate ensembles of statistical mechanics is violated.

  16. Multivariate probabilistic projections using imperfect climate models part I: outline of methodology

    NASA Astrophysics Data System (ADS)

    Sexton, David M. H.; Murphy, James M.; Collins, Mat; Webb, Mark J.

    2012-06-01

    We demonstrate a method for making probabilistic projections of climate change at global and regional scales, using examples consisting of the equilibrium response to doubled CO2 concentrations of global annual mean temperature and regional climate changes in summer and winter temperature and precipitation over Northern Europe and England-Wales. This method combines information from a perturbed physics ensemble, a set of international climate models, and observations. Our approach is based on a multivariate Bayesian framework which enables the prediction of a joint probability distribution for several variables constrained by more than one observational metric. This is important if different sets of impacts scientists are to use these probabilistic projections to make coherent forecasts for the impacts of climate change, by inputting several uncertain climate variables into their impacts models. Unlike a single metric, multiple metrics reduce the risk of rewarding a model variant which scores well due to a fortuitous compensation of errors rather than because it is providing a realistic simulation of the observed quantity. We provide some physical interpretation of how the key metrics constrain our probabilistic projections. The method also has a quantity, called discrepancy, which represents the degree of imperfection in the climate model i.e. it measures the extent to which missing processes, choices of parameterisation schemes and approximations in the climate model affect our ability to use outputs from climate models to make inferences about the real system. Other studies have, sometimes without realising it, treated the climate model as if it had no model error. We show that omission of discrepancy increases the risk of making over-confident predictions. Discrepancy also provides a transparent way of incorporating improvements in subsequent generations of climate models into probabilistic assessments. The set of international climate models is used to derive

  17. The Specificity and Flexibility of L1 Reverse Transcription Priming at Imperfect T-Tracts

    PubMed Central

    Viollet, Sébastien; Mir, Ashfaq Ali; Gabus, Caroline; Darlix, Jean-Luc; Cristofari, Gaël

    2013-01-01

    L1 retrotransposons have a prominent role in reshaping mammalian genomes. To replicate, the L1 ribonucleoprotein particle (RNP) first uses its endonuclease (EN) to nick the genomic DNA. The newly generated DNA end is subsequently used as a primer to initiate reverse transcription within the L1 RNA poly(A) tail, a process known as target-primed reverse transcription (TPRT). Prior studies demonstrated that most L1 insertions occur into sequences related to the L1 EN consensus sequence (degenerate 5′-TTTT/A-3′ sites) and frequently preceded by imperfect T-tracts. However, it is currently unclear whether—and to which degree—the liberated 3′-hydroxyl extremity on the genomic DNA needs to be accessible and complementary to the poly(A) tail of the L1 RNA for efficient priming of reverse transcription. Here, we employed a direct assay for the initiation of L1 reverse transcription to define the molecular rules that guide this process. First, efficient priming is detected with as few as 4 matching nucleotides at the primer 3′ end. Second, L1 RNP can tolerate terminal mismatches if they are compensated within the 10 last bases of the primer by an increased number of matching nucleotides. All terminal mismatches are not equally detrimental to DNA extension, a C being extended at higher levels than an A or a G. Third, efficient priming in the context of duplex DNA requires a 3′ overhang. This suggests the possible existence of additional DNA processing steps, which generate a single-stranded 3′ end to allow L1 reverse transcription. Based on these data we propose that the specificity of L1 reverse transcription initiation contributes, together with the specificity of the initial EN cleavage, to the distribution of new L1 insertions within the human genome. PMID:23675310

  18. The specificity and flexibility of l1 reverse transcription priming at imperfect T-tracts.

    PubMed

    Monot, Clément; Kuciak, Monika; Viollet, Sébastien; Mir, Ashfaq Ali; Gabus, Caroline; Darlix, Jean-Luc; Cristofari, Gaël

    2013-05-01

    L1 retrotransposons have a prominent role in reshaping mammalian genomes. To replicate, the L1 ribonucleoprotein particle (RNP) first uses its endonuclease (EN) to nick the genomic DNA. The newly generated DNA end is subsequently used as a primer to initiate reverse transcription within the L1 RNA poly(A) tail, a process known as target-primed reverse transcription (TPRT). Prior studies demonstrated that most L1 insertions occur into sequences related to the L1 EN consensus sequence (degenerate 5'-TTTT/A-3' sites) and frequently preceded by imperfect T-tracts. However, it is currently unclear whether--and to which degree--the liberated 3'-hydroxyl extremity on the genomic DNA needs to be accessible and complementary to the poly(A) tail of the L1 RNA for efficient priming of reverse transcription. Here, we employed a direct assay for the initiation of L1 reverse transcription to define the molecular rules that guide this process. First, efficient priming is detected with as few as 4 matching nucleotides at the primer 3' end. Second, L1 RNP can tolerate terminal mismatches if they are compensated within the 10 last bases of the primer by an increased number of matching nucleotides. All terminal mismatches are not equally detrimental to DNA extension, a C being extended at higher levels than an A or a G. Third, efficient priming in the context of duplex DNA requires a 3' overhang. This suggests the possible existence of additional DNA processing steps, which generate a single-stranded 3' end to allow L1 reverse transcription. Based on these data we propose that the specificity of L1 reverse transcription initiation contributes, together with the specificity of the initial EN cleavage, to the distribution of new L1 insertions within the human genome. PMID:23675310

  19. Investigating species co-occurrence patterns when species are detected imperfectly

    USGS Publications Warehouse

    MacKenzie, D.I.; Bailey, L.L.; Nichols, J.D.

    2004-01-01

    1. Over the last 30 years there has been a great deal of interest in investigating patterns of species co-occurrence across a number of locations, which has led to the development of numerous methods to determine whether there is evidence that a particular pattern may not have occurred by random chance. 2. A key aspect that seems to have been largely overlooked is the possibility that species may not always be detected at a location when present, which leads to 'false absences' in a species presence/absence matrix that may cause incorrect inferences to be made about co-occurrence patterns. Furthermore, many of the published methods for investigating patterns of species co-occurrence do not account for potential differences in the site characteristics that may partially (at least) explain non-random patterns (e.g. due to species having similar/different habitat preferences). 3. Here we present a statistical method for modelling co-occurrence patterns between species while accounting for imperfect detection and site characteristics. This method requires that multiple presence/absence surveys for the species be conducted over a reasonably short period of time at most sites. The method yields unbiased estimates of probabilities of occurrence, and is practical when the number of species is small (< 4). 4. To illustrate the method we consider data collected on two terrestrial salamander species, Plethodonjordani and members of the Plethodon glutinosus complex, collected in the Great Smoky Mountains National Park, USA. We find no evidence that the species do not occur independently at sites once site elevation has been allowed for, although we find some evidence of a statistical interaction between species in terms of detectability that we suggest may be due to changes in relative abundances.

  20. Anisotropic elliptical dichroism and influence of imperfection of circular polarization upon anisotropic circular dichroism

    SciTech Connect

    Wakabayashi, Masamitsu; Yokojima, Satoshi; Fukaminato, Tuyoshi; Ohtani, Hiroyuki; Nakamura, Shinichiro

    2015-04-21

    In spite of the importance of anisotropic circular dichroism, in practice, it is difficult to get rid of the artifacts that arise from the imperfection of the circular polarization. Undesirable linear dichroism, interference of two orthogonal polarization states, and linear birefringence prevent us from making accurate measurements. We propose a theoretical method for evaluating the contributions of the first two, which are thought to be the main artifacts when specimens are not thick enough. Using the time-dependent perturbation theory and taking into account the direction of light propagation toward an orientationally fixed molecule, we formulated the transition probability of systems perturbed by arbitrarily polarized light and the absorption difference associated with two kinds of polarized light. We also formulated, as an extension of the dissymmetry factor of circular dichroism, a newly defined dissymmetry factor associated with two arbitrary polarization states. Furthermore, we considered a mixed-state of photon ensemble in which polarization states distribute at a certain width around a certain average. Although the purity of polarization and ellipticity does not correspond immediately, by considering the mixed state it is possible to treat them consistently. We used quantum statistical mechanics to describe the absorption difference for two kinds of photon ensembles and applied the consequent formula to examine the reported experimental results of single-molecule chiroptical responses under discussion in the recent past. The artifacts are theoretically suggested to be sensitive to the incident direction of elliptically polarized light and to the oriented systems, the ellipticity, and the orientation of ellipse. The mixed state has little, if any, effect when the polarization state distribution is narrow.