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Sample records for q devices

  1. High-Q CMOS-integrated photonic crystal microcavity devices

    PubMed Central

    Mehta, Karan K.; Orcutt, Jason S.; Tehar-Zahav, Ofer; Sternberg, Zvi; Bafrali, Reha; Meade, Roy; Ram, Rajeev J.

    2014-01-01

    Integrated optical resonators are necessary or beneficial in realizations of various functions in scaled photonic platforms, including filtering, modulation, and detection in classical communication systems, optical sensing, as well as addressing and control of solid state emitters for quantum technologies. Although photonic crystal (PhC) microresonators can be advantageous to the more commonly used microring devices due to the former's low mode volumes, fabrication of PhC cavities has typically relied on electron-beam lithography, which precludes integration with large-scale and reproducible CMOS fabrication. Here, we demonstrate wavelength-scale polycrystalline silicon (pSi) PhC microresonators with Qs up to 60,000 fabricated within a bulk CMOS process. Quasi-1D resonators in lateral p-i-n structures allow for resonant defect-state photodetection in all-silicon devices, exhibiting voltage-dependent quantum efficiencies in the range of a few 10 s of %, few-GHz bandwidths, and low dark currents, in devices with loaded Qs in the range of 4,300–9,300; one device, for example, exhibited a loaded Q of 4,300, 25% quantum efficiency (corresponding to a responsivity of 0.31 A/W), 3 GHz bandwidth, and 30 nA dark current at a reverse bias of 30 V. This work demonstrates the possibility for practical integration of PhC microresonators with active electro-optic capability into large-scale silicon photonic systems. PMID:24518161

  2. Quasi-one dimensional (Q1D) nanostructures: Synthesis, integration and device application

    NASA Astrophysics Data System (ADS)

    Chien, Chung-Jen

    Quasi-one-dimensional (Q1D) nanostructures such as nanotubes and nanowires have been widely regarded as the potential building blocks for nanoscale electronic, optoelectronic and sensing devices. In this work, the content can be divided into three categories: Nano-material synthesis and characterizations, alignment and integration, physical properties and application. The dissertation consists of seven chapters as following. Chapter 1 will give an introduction to low dimensional nano-materials. Chapter 2 explains the mechanism how Q1D nanostructure grows. Chapter 3 describes the methods how we horizontally and vertically align the Q1D nanostructure. Chapter 4 and 5 are the electrical and optical device characterization respectively. Chapter 6 demonstrates the integration of Q1D nanostructures and the device application. The last chapter will discuss the future work and conclusion of the thesis.

  3. Air-Q intubating laryngeal airway: A study of the second generation supraglottic airway device

    PubMed Central

    Attarde, Viren Bhaskar; Kotekar, Nalini; Shetty, Sarika M

    2016-01-01

    Background and Aims: Air-Q intubating laryngeal mask airway (ILA) is used as a supraglottic airway device and as a conduit for endotracheal intubation. This study aims to assess the efficacy of the Air-Q ILA regarding ease of insertion, adequacy of ventilation, rate of successful intubation, haemodynamic response and airway morbidity. Methods: Sixty patients presenting for elective surgery at our Medical College Hospital were selected. Following adequate premedication, baseline vital parameters, pulse rate and blood pressure were recorded. Air-Q size 3.5 for patients 50-70 kg and size 4.5 for 70-100 kg was selected. After achieving adequate intubating conditions, Air-Q ILA was introduced. Confirming adequate ventilation, appropriate sized endotracheal tube was advanced through the Air-Q blindly to intubate the trachea. Placement of the endotracheal tube in trachea was confirmed. Results: Air-Q ILA was successfully inserted in 88.3% of patients in first attempt and 11.7% patients in second attempt. Ventilation was adequate in 100% of patients. Intubation was successful in 76.7% of patients with Air-Q ILA. 23.3% of patients were intubated by direct laryngoscopy following failure with two attempts using Air-Q ILA. Post-intubation the change in heart rate was statistically significant (P < 0.0001). 10% of patients were noted to have a sore throat and 5% of patients had mild airway trauma. Conclusion: Air-Q ILA is a reliable device as a supraglottic airway ensuring adequate ventilation as well as a conduit for endotracheal intubation. It benefits the patient by avoiding the stress of direct laryngoscopy and is also superior alternative device for use in a difficult airway. PMID:27212722

  4. Processing of Diamond for Integrated Optic Devices Using Q-Switched Nd:YAG Laser at Different Wavelengths

    NASA Astrophysics Data System (ADS)

    Sudheer, S. K.; Pillai, V. P. Mahadevan; Nayar, V. U.

    In the present investigation, a Q-switched Nd:YAG laser is used to study the various aspects of diamond processing for fabricating integrated optic and UV optoelectronic devices. Diamond is a better choice of substrate compared to silicon and gallium arsenide for the fabrication of waveguides to perform operations such as modulation, switching, multiplexing, and filtering, particularly in the ultraviolet spectrum. The experimental setup of the present investigation consists of two Q-Switched Nd:YAG lasers capable of operating at wavelengths of 1064 nm and 532 nm. The diamond cutting is performed using these two wavelengths by making the "V"-shaped groove with various opening angle. The variation of material loss of diamond during cutting is noted for the two wavelengths. The cut surface morphology and elemental and structural analysis of graphite formed during processing in both cases are compared using scanning electron microscopy (SEM) and laser Raman spectroscopy. Both the Q-Switched Nd:YAG laser systems (at 1064 nm and 532 nm) show very good performance in terms of peak-to-peak output stability, minimal spot diameter, smaller divergence angle, higher peak power in Q-switched mode, and good fundamental TEM00 mode quality for processing natural diamond stones. Less material loss and minimal micro cracks are achieved with wavelength 532 nm whereas a better diamond cut surface is achieved with processing at 1064 nm with minimum roughness.

  5. Label-free detection with high-Q microcavities: a review of biosensing mechanisms for integrated devices

    PubMed Central

    Yang, Lan

    2015-01-01

    Optical microcavities that confine light in high-Q resonance promise all of the capabilities required for a successful next-generation microsystem biodetection technology. Label-free detection down to single molecules as well as operation in aqueous environments can be integrated cost-effectively on microchips, together with other photonic components, as well as electronic ones. We provide a comprehensive review of the sensing mechanisms utilized in this emerging field, their physics, engineering and material science aspects, and their application to nanoparticle analysis and biomolecular detection. We survey the most recent developments such as the use of mode splitting for self-referenced measurements, plasmonic nanoantennas for signal enhancements, the use of optical force for nanoparticle manipulation as well as the design of active devices for ultra-sensitive detection. Furthermore, we provide an outlook on the exciting capabilities of functionalized high-Q microcavities in the life sciences. PMID:26918228

  6. DIGITAL Q METER

    DOEpatents

    Briscoe, W.L.

    1962-02-13

    A digital Q meter is described for measuring the Q of mechanical or electrical devices. The meter comprises in combination a transducer coupled to an input amplifier, and an upper and lower level discriminator coupled to the amplifier and having their outputs coupled to an anticoincidence gate. The output of the gate is connected to a scaler. The lower level discriminator is adjusted to a threshold level of 36.8 percent of the operating threshold level of the upper level discriminator. (AEC)

  7. Q fever.

    PubMed

    Tissot-Dupont, Hervé; Raoult, Didier

    2008-09-01

    Q fever is a worldwide zoonosis caused by the pathogen Coxiella burnetii causing acute and chronic clinical manifestations. The name "Q fever" derives from "Query fever" and was given in 1935 following an outbreak of febrile illness in an abattoir in Queensland, Australia. C burnetii is considered a potential agent of bioterrorism (class B by the Centers for Disease Control). PMID:18755387

  8. Proceedings of US/Japan workshop, Q219 on high heat flux components and plasma surface interactions for next fusion devices

    SciTech Connect

    Ulrickson, M.A.; Stevens, P.L.; Hino, T.; Hirohata, Y.

    1996-12-01

    This report contains the viewgraphs from the proceedings of US/Japan Workshop on High Heat Flux Components and Plasma Surface Interactions for Next Fusion Devices. Some of the general topics covered by this report are: PFC/PSI in tokamak and helical devices; development of high heat flux components; PSIS and plasma facing materials;tritium; and material damage.

  9. Q fever

    MedlinePlus

    ... fever is antibiotics. For early-stage Q fever, doxycycline is the recommended antibiotic. If you have the ... fever. Your health care provider may prescribe both doxycycline and hydroxychloroquine. You may need to take antibiotics ...

  10. Q Fever

    PubMed Central

    Maurin, M.; Raoult, D.

    1999-01-01

    Q fever is a zoonosis with a worldwide distribution with the exception of New Zealand. The disease is caused by Coxiella burnetii, a strictly intracellular, gram-negative bacterium. Many species of mammals, birds, and ticks are reservoirs of C. burnetii in nature. C. burnetii infection is most often latent in animals, with persistent shedding of bacteria into the environment. However, in females intermittent high-level shedding occurs at the time of parturition, with millions of bacteria being released per gram of placenta. Humans are usually infected by contaminated aerosols from domestic animals, particularly after contact with parturient females and their birth products. Although often asymptomatic, Q fever may manifest in humans as an acute disease (mainly as a self-limited febrile illness, pneumonia, or hepatitis) or as a chronic disease (mainly endocarditis), especially in patients with previous valvulopathy and to a lesser extent in immunocompromised hosts and in pregnant women. Specific diagnosis of Q fever remains based upon serology. Immunoglobulin M (IgM) and IgG antiphase II antibodies are detected 2 to 3 weeks after infection with C. burnetii, whereas the presence of IgG antiphase I C. burnetii antibodies at titers of ≥1:800 by microimmunofluorescence is indicative of chronic Q fever. The tetracyclines are still considered the mainstay of antibiotic therapy of acute Q fever, whereas antibiotic combinations administered over prolonged periods are necessary to prevent relapses in Q fever endocarditis patients. Although the protective role of Q fever vaccination with whole-cell extracts has been established, the population which should be primarily vaccinated remains to be clearly identified. Vaccination should probably be considered in the population at high risk for Q fever endocarditis. PMID:10515901

  11. Q fever.

    PubMed Central

    Reimer, L G

    1993-01-01

    Q fever is an acute febrile illness first described in 1935 and now seen in many parts of the world. Human infection follows exposure to animals, especially domestic livestock. Recent outbreaks in metropolitan areas have implicated cats as the carrier of disease to humans. The etiologic agent, Coxiella burnetti, belongs to the family Rickettsiaceae, although it has distinct genetic characteristics and modes of transmission. Most recent attention has been focused on a number of large outbreaks of Q fever associated with medical research involving pregnant sheep. Although most infections are self-limited, some patients require prolonged treatment. Recent vaccines have had encouraging success in the prevention of disease in individuals at high risk of exposure. PMID:8358703

  12. Interstitial deletion (6)q13q15

    SciTech Connect

    Gershoni-Baruch, R.; Mandel, H.; Bar El, H.; Bar-Nizan, N.; Borochowitz, Z.; Dar, Hanna

    1996-04-24

    We report on a 2-year-old child with psychomotor retardation, facial and urogenital anomalies. His chromosome constitution was 46,XY,del(6)(q13q15). This case further contributes to the karyotype-phenotype correlation of proximal deletion 6q syndromes. 18 refs., 3 figs., 1 tab.

  13. Quantum codes from cyclic codes over F_q+uF_q+vF_q+uvF_q

    NASA Astrophysics Data System (ADS)

    Ashraf, Mohammad; Mohammad, Ghulam

    2016-07-01

    In this paper, we study quantum codes over F_q from cyclic codes over F_q+uF_q+vF_q+uvF_q, where u^2=u,~v^2=v,~uv=vu,~q=p^m , and p is an odd prime. We give the structure of cyclic codes over F_q+uF_q+vF_q+uvF_q and obtain self-orthogonal codes over F_q as Gray images of linear and cyclic codes over F_q+uF_q+vF_q+uvF_q . In particular, we decompose a cyclic code over F_q+uF_q+vF_q+uvF_q into four cyclic codes over F_q to determine the parameters of the corresponding quantum code.

  14. Coenzyme Q10 Therapy

    PubMed Central

    Garrido-Maraver, Juan; Cordero, Mario D.; Oropesa-Ávila, Manuel; Fernández Vega, Alejandro; de la Mata, Mario; Delgado Pavón, Ana; de Miguel, Manuel; Pérez Calero, Carmen; Villanueva Paz, Marina; Cotán, David; Sánchez-Alcázar, José A.

    2014-01-01

    For a number of years, coenzyme Q10 (CoQ10) was known for its key role in mitochondrial bioenergetics; later studies demonstrated its presence in other subcellular fractions and in blood plasma, and extensively investigated its antioxidant role. These 2 functions constitute the basis for supporting the clinical use of CoQ10. Also, at the inner mitochondrial membrane level, CoQ10 is recognized as an obligatory cofactor for the function of uncoupling proteins and a modulator of the mitochondrial transition pore. Furthermore, recent data indicate that CoQ10 affects the expression of genes involved in human cell signaling, metabolism and transport, and some of the effects of CoQ10 supplementation may be due to this property. CoQ10 deficiencies are due to autosomal recessive mutations, mitochondrial diseases, aging-related oxidative stress and carcinogenesis processes, and also statin treatment. Many neurodegenerative disorders, diabetes, cancer, and muscular and cardiovascular diseases have been associated with low CoQ10 levels as well as different ataxias and encephalomyopathies. CoQ10 treatment does not cause serious adverse effects in humans and new formulations have been developed that increase CoQ10 absorption and tissue distribution. Oral administration of CoQ10 is a frequent antioxidant strategy in many diseases that may provide a significant symptomatic benefit. PMID:25126052

  15. Q fever - a review.

    PubMed

    Marrie, T J

    1990-08-01

    Q or "query" fever is a zoonosis caused by the organism Coxiella burnetii. Cattle, sheep and goats are the most common reservoirs of this organism. The placenta of infected animals contains high numbers (up to 10(9)/g) of C. burnetii. Aerosols occur at the time of parturition and man becomes infected following inhalation of the microorganism. The spectrum of illness in man is wide and consists of acute and chronic forms. Acute Q fever is most often a self-limited flu-like illness but may include pneumonia, hepatitis, or meningoencephalitis. Chronic Q fever almost always means endocarditis and rarely osteomyelitis. Chronic Q fever is not known to occur in animals other than man. An increased abortion and stillbirth rate are seen in infected domestic ungulates.Four provinces (Nova Scotia, New Brunswick, Ontario and Alberta) reported cases of Q fever in 1989.A vaccine for Q fever has recently been licensed in Australia. PMID:17423643

  16. The Q, Compound Q is Finally Deciphered

    PubMed Central

    Bhagi-Damodaran, Ambika; Lu, Yi

    2015-01-01

    Methane monooxygenases (MMOs) activate the high energy C-H bond of methane and convert it to methanol with high selectivity and under physiological conditions. Despite decades of efforts focusing on elucidating the structure, function and mechanism of soluble MMOs, the structure of a key intermediate (called compound Q) remained unknown. This article highlights a recent report by Banerjee et. al. which not only firmly establishes the core-structure of Q, but also provides significant insight into its formation, reaction with methane and eventual decay. PMID:26346336

  17. Large gauged Q balls

    NASA Astrophysics Data System (ADS)

    Anagnostopoulos, K. N.; Axenides, M.; Floratos, E. G.; Tetradis, N.

    2001-12-01

    We study Q balls associated with local U(1) symmetries. Such Q balls are expected to become unstable for large values of their charge because of the repulsion mediated by the gauge force. We consider the possibility that the repulsion is eliminated through the presence in the interior of the Q ball of fermions with charge opposite to that of the scalar condensate. Another possibility is that two scalar condensates of opposite charge form in the interior. We demonstrate that both these scenarios can lead to the existence of classically stable, large, gauged Q balls. We present numerical solutions, as well as an analytical treatment of the ``thin-wall'' limit.

  18. The symmetric q-oscillator algebra: q-coherent states, q-Bargmann-Fock realization and continuous q-Hermite polynomials with 0 < q < 1

    NASA Astrophysics Data System (ADS)

    Fakhri, H.; Hashemi, A.

    2016-01-01

    The symmetric q-analysis is used to construct a type of minimum-uncertainty q-coherent states in the Fock representation space of the symmetric q-oscillator ∗-algebra with 0 < q < 1. Then, its corresponding q-Hermite polynomials are derived by using the q-Bargmann-Fock realization of the symmetric q-oscillator algebra.

  19. Coenzyme Q10 (PDQ)

    MedlinePlus

    ... and use of CoQ10 as a complementary or alternative treatment for cancer? CoQ10 was first identified in 1957. Its chemical ... of CAM therapies originally considered to be purely alternative approaches are finding a place in cancer treatment—not as cures, but as complementary therapies that ...

  20. Q-branes

    NASA Astrophysics Data System (ADS)

    Abel, Steven; Kehagias, Alex

    2015-11-01

    Non-topological solitons (Q-balls) are discussed in some stringy settings. Our main result is that the dielectric D-brane system of Myers admits non-abelian Q-ball solutions on their world-volume, in which N D p-branes relax to the standard dielectric form outside the Q-ball, but assume a more diffuse configuration at its centre. We also consider how Q-balls behave in the bulk of extra-dimensional theories, or on wrapped branes. We demonstrate that they carry Kaluza-Klein charge and possess a corresponding Kaluza-Klein tower of states just as normal particles, and we discuss surface energy effects by finding exact Q-ball solutions in models with a specific logarithmic potential.

  1. Compact Q-balls

    NASA Astrophysics Data System (ADS)

    Bazeia, D.; Losano, L.; Marques, M. A.; Menezes, R.; da Rocha, R.

    2016-07-01

    In this work we deal with non-topological solutions of the Q-ball type in two space-time dimensions, in models described by a single complex scalar field that engenders global symmetry. The main novelty is the presence of stable Q-balls solutions that live in a compact interval of the real line and appear from a family of models controlled by two distinct parameters. We find analytical solutions and study their charge and energy, and show how to control the parameters to make the Q-balls classically and quantum mechanically stable.

  2. Optically detonated explosive device

    NASA Technical Reports Server (NTRS)

    Yang, L. C.; Menichelli, V. J. (Inventor)

    1974-01-01

    A technique and apparatus for optically detonating insensitive high explosives, is disclosed. An explosive device is formed by containing high explosive material in a house having a transparent window. A thin metallic film is provided on the interior surface of the window and maintained in contact with the high explosive. A laser pulse provided by a Q-switched laser is focussed on the window to vaporize the metallic film and thereby create a shock wave which detonates the high explosive. Explosive devices may be concurrently or sequentially detonated by employing a fiber optic bundle to transmit the laser pulse to each of the several individual explosive devices.

  3. Q fever - early

    MedlinePlus

    ... burnetii , which live in domestic animals such as cattle, sheep, goats, birds, and cats. Some wild animals and ticks also carry the bacteria. You can get Q fever by drinking raw (unpasteurized) milk, or after breathing ...

  4. Popular Chat Day Q & A

    MedlinePlus

    ... Day / Popular Chat Day Q & A Popular Chat Day Q & A Print Read students’ most popular questions ... Cool Order Free Materials National Drugs & Alcohol Chat Day Chat Day Participant FAQs Popular Chat Day Q & ...

  5. Deletion (2)(q37)

    SciTech Connect

    Stratton, R.F.; Tolworthy, J.A.; Young, R.S.

    1994-06-01

    We report on a 5-month-old girl with widely spaced nipples, redundant nuchal skin, coarctation of the aorta, anal atresia with distal fistula, postnatal growth retardation, hypotonia, and sparse scalp hair. Initial clinical assessment suggested the diagnosis of Ullrich-Turner syndrome. Chromosome analysis showed a 46,XX,del(2)(q37) karyotype in peripheral lymphocytes. We compare her findings to those of other reported patients with terminal deletions of 2q. 8 refs., 2 figs., 1 tab.

  6. Three-region specific microdissection libraries for the long arm of human chromosome 2, regions q33-q35, q31-q32, and q23-q24

    SciTech Connect

    Yu, J.; Tong, S.; Whittier, A.

    1995-09-01

    Three region-specific libraries have been constructed from the long arm of human chromosome 2, including regions 2q33-35 (2Q2 library), 2q31-32 (2Q3) and 2q23-24 (2Q4). Chromosome microdissection and the MboI linker-adaptor microcloning techniques were used in constructing these libraries. The libraries comprised hundreds of thousands of microclones in each library. Approximately half of the microclones in the library contained unique or low-copy number sequence inserts. The insert sizes ranged between 50 and 800 bp, with a mean of 130-190 bp. Southern blot analysis of individual unique sequence microclones showed that 70-94% of the microclones were derived from the dissected region. 31 unique sequence microclones from the 2Q2 library, 31 from 2Q3, and 30 from 2Q4, were analyzed for insert sizes, the hybridizing genomic HindIII fragment sizes, and cross-hybridization to rodent species. These libraries and the short insert microclones derived from the libraries should be useful for high resolution physical mapping, sequence-ready reagents for large scale genomic sequencing, and positional cloning of disease-related genes assigned to these regions, e.g. the recessive familial amyotrophic lateral sclerosis assigned to 2q33-q35, and a type I diabetes susceptibility gene to 2q31-q33. 17 refs., 5 figs., 2 tabs.

  7. Q-instantons

    NASA Astrophysics Data System (ADS)

    Bergshoeff, E. A.; Hartong, J.; Ploegh, A.; Sorokin, D.

    2008-06-01

    We construct the half-supersymmetric instanton solutions that are electric-magnetically dual to the recently discussed half-supersymmetric Q7-branes. We call these instantons ``Q-instantons''. Whereas the D-instanton is most conveniently described using the RR axion χ and the dilaton phi, the Q-instanton is most conveniently described using a different set of fields (χ',T), where χ' is an axionic scalar. The real part of the Q-instanton on-shell action is a function of T and the imaginary part is linear in χ'. Discrete shifts of the axion χ' correspond to PSL(2, Bbb Z) transformations that are of finite order. These are e.g. pure S-duality transformations relating weak and strongly coupled regimes. We argue that near each orbifold point of the quantum axion-dilaton moduli space {τ mid τ in PSL(2, Bbb R)/(SO(2) × PSL(2, Bbb Z))} the higher order Script R4 terms in the string effective action contain contributions from an infinite sum of single multiply-charged instantons with the Q-instantons corresponding to the orbifold points τ = i, ρ.

  8. Tandem duplication of chromosome 14 (q12q13).

    PubMed

    Verma, R S; Kleyman, S M; Conte, R A; Laqui-Pili, C; Bennett, H

    1997-01-01

    A nine-years-old Egyptian boy was referred for speech and language delay. He has an I.Q. of 35 which is in the moderately to severely delayed range. Routine cytogenetic and FISH-techniques revealed a de novo tandem duplication of chromosome 14 bands q12 and q13, i.e., 46, XY, dup (14)(q12q13) and there are no investigations reporting a direct de novo duplication for this region. PMID:9526614

  9. Coenzyme Q and Mitochondrial Disease

    ERIC Educational Resources Information Center

    Quinzii, Catarina M.; Hirano, Michio

    2010-01-01

    Coenzyme Q[subscript 10] (CoQ[subscript 10]) is an essential electron carrier in the mitochondrial respiratory chain and an important antioxidant. Deficiency of CoQ[subscript 10] is a clinically and molecularly heterogeneous syndrome, which, to date, has been found to be autosomal recessive in inheritance and generally responsive to CoQ[subscript…

  10. The q-harmonic oscillators, q-coherent states and the q-symplecton

    NASA Technical Reports Server (NTRS)

    Biedenharn, L. C.; Lohe, M. A.; Nomura, Masao

    1993-01-01

    The recently introduced notion of a quantum group is discussed conceptually and then related to deformed harmonic oscillators ('q-harmonic oscillators'). Two developments in applying q-harmonic oscillators are reviewed: q-coherent states and the q-symplecton.

  11. Big Brother I. Q.

    ERIC Educational Resources Information Center

    Gilliatt, Michael T.

    1977-01-01

    Lists four harmful consequences that critics suggest educational testing may have, and in discussing the danger that I.Q. testing may place an indelible stamp of inferiority upon students, this research re-examines the purpose of testing. (Author/RK)

  12. q-bosons and the q-analogue quantized field

    NASA Technical Reports Server (NTRS)

    Nelson, Charles A.

    1995-01-01

    The q-analogue coherent states are used to identify physical signatures for the presence of a 1-analogue quantized radiation field in the q-CS classical limits where the absolute value of z is large. In this quantum-optics-like limit, the fractional uncertainties of most physical quantities (momentum, position, amplitude, phase) which characterize the quantum field are O(1). They only vanish as O(1/absolute value of z) when q = 1. However, for the number operator, N, and the N-Hamiltonian for a free q-boson gas, H(sub N) = h(omega)(N + 1/2), the fractional uncertainties do still approach zero. A signature for q-boson counting statistics is that (Delta N)(exp 2)/ (N) approaches 0 as the absolute value of z approaches infinity. Except for its O(1) fractional uncertainty, the q-generalization of the Hermitian phase operator of Pegg and Barnett, phi(sub q), still exhibits normal classical behavior. The standard number-phase uncertainty-relation, Delta(N) Delta phi(sub q) = 1/2, and the approximate commutation relation, (N, phi(sub q)) = i, still hold for the single-mode q-analogue quantized field. So, N and phi(sub q) are almost canonically conjugate operators in the q-CS classical limit. The q-analogue CS's minimize this uncertainty relation for moderate (absolute value of z)(exp 2).

  13. Disappearing Q operator

    NASA Astrophysics Data System (ADS)

    Jones, H. F.; Rivers, R. J.

    2007-01-01

    In the Schrödinger formulation of non-Hermitian quantum theories a positive-definite metric operator η≡e-Q must be introduced in order to ensure their probabilistic interpretation. This operator also gives an equivalent Hermitian theory, by means of a similarity transformation. If, however, quantum mechanics is formulated in terms of functional integrals, we show that the Q operator makes only a subliminal appearance and is not needed for the calculation of expectation values. Instead, the relation to the Hermitian theory is encoded via the external source j(t). These points are illustrated and amplified for two non-Hermitian quantum theories: the Swanson model, a non-Hermitian transform of the simple harmonic oscillator, and the wrong-sign quartic oscillator, which has been shown to be equivalent to a conventional asymmetric quartic oscillator.

  14. Disappearing Q operator

    SciTech Connect

    Jones, H. F.; Rivers, R. J.

    2007-01-15

    In the Schroedinger formulation of non-Hermitian quantum theories a positive-definite metric operator {eta}{identical_to}e{sup -Q} must be introduced in order to ensure their probabilistic interpretation. This operator also gives an equivalent Hermitian theory, by means of a similarity transformation. If, however, quantum mechanics is formulated in terms of functional integrals, we show that the Q operator makes only a subliminal appearance and is not needed for the calculation of expectation values. Instead, the relation to the Hermitian theory is encoded via the external source j(t). These points are illustrated and amplified for two non-Hermitian quantum theories: the Swanson model, a non-Hermitian transform of the simple harmonic oscillator, and the wrong-sign quartic oscillator, which has been shown to be equivalent to a conventional asymmetric quartic oscillator.

  15. Nonclassical properties of the q -coherent and q -cat states of the Biedenharn-Macfarlane q oscillator with q >1

    NASA Astrophysics Data System (ADS)

    Fakhri, H.; Hashemi, A.

    2016-01-01

    This paper has been motivated by a recent paper by Dey [Phys. Rev. D 91, 044024 (2015), 10.1103/PhysRevD.91.044024] on the known Arik-Coon q oscillator. We construct q coherent, even and odd q -cat states in Fock representation for the Biedenharn-Macfarlane q oscillator with q >1 and study their nonclassical properties. The q -coherent states minimize the Heisenberg uncertainty relation between the generalized position and momentum operators as well as the x and y components of a q -deformed su(1 ,1 ) algebra in the Schwinger boson representation. The latter is also minimized by the even and odd q -cat states. We show that, contrary to the undeformed harmonic oscillator, the squeezing effect in both position and momentum operators can be exhibited by odd q -cat states. It is also violated by even q -cat states. Furthermore, it is shown that the antibunching effect and sub-Poissonian or super-Poissonian statistics can simultaneously appear by each of the even or odd q -cat states. Finally, a unitary Fock representation of the q -deformed su(1 ,1 ) algebra is obtained by the q -deformed Bargmann-Fock realization.

  16. Q Fever Update, Maritime Canada

    PubMed Central

    Marrie, Thomas J.; Campbell, Nancy; McNeil, Shelly A.; Webster, Duncan

    2008-01-01

    Since the 1990s, reports of Q fever in Nova Scotia, Canada, have declined. Passive surveillance for Q fever in Nova Scotia and its neighboring provinces in eastern Canada indicates that the clinical manifestation of Q fever in the Maritime provinces is pneumonia and that incidence of the disease may fluctuate. PMID:18258080

  17. What happens to Q balls if Q is so large?

    NASA Astrophysics Data System (ADS)

    Sakai, Nobuyuki; Tamaki, Takashi

    2012-05-01

    In the system of a gravitating Q ball, there is a maximum charge Qmax⁡ inevitably, while in flat spacetime there is no upper bound on Q in typical models such as the Affleck-Dine model. Theoretically, the charge Q is a free parameter, and phenomenologically it could increase by charge accumulation. We address a question of what happens to Q balls if Q is close to Qmax⁡. First, without specifying a model, we show analytically that inflation cannot take place in the core of a Q ball, contrary to the claim of previous work. Next, for the Affleck-Dine model, we analyze perturbation of equilibrium solutions with Q≈Qmax⁡ by numerical analysis of dynamical field equations. We find that the extremal solution with Q=Qmax⁡ and unstable solutions around it are “critical solutions,” which means the threshold of black-hole formation.

  18. Gauged Q-balls

    NASA Technical Reports Server (NTRS)

    Lee, Kimyeong; Stein-Schabes, Jaime A.; Watkins, Richard; Widrow, Lawrence M.

    1988-01-01

    Classical non-topological soliton configurations are considered within the theory of a complex scalar field with a gauged U symmetry. Their existence and stability against dispersion are demonstrated and some of their properties are investigated analytically and numerically. The soliton configuration is such that inside the soliton the local U symmetry is broken, the gauge field becomes massive and for a range of values of the coupling constants the soliton becomes a superconductor pushing the charge to the surface. Furthermore, because of the repulsive Coulomb force, there is a maximum size for these objects, making impossible the existence of Q-matter in bulk form. Also briefly discussed are solitons with fermions in a U gauge theory.

  19. Q fever — a review

    PubMed Central

    Marrie, Thomas J.

    1990-01-01

    Q or “query” fever is a zoonosis caused by the organism Coxiella burnetii. Cattle, sheep and goats are the most common reservoirs of this organism. The placenta of infected animals contains high numbers (up to 109/g) of C. burnetii. Aerosols occur at the time of parturition and man becomes infected following inhalation of the microorganism. The spectrum of illness in man is wide and consists of acute and chronic forms. Acute Q fever is most often a self-limited flu-like illness but may include pneumonia, hepatitis, or meningoencephalitis. Chronic Q fever almost always means endocarditis and rarely osteomyelitis. Chronic Q fever is not known to occur in animals other than man. An increased abortion and stillbirth rate are seen in infected domestic ungulates. Four provinces (Nova Scotia, New Brunswick, Ontario and Alberta) reported cases of Q fever in 1989. A vaccine for Q fever has recently been licensed in Australia. ImagesFigure 1. PMID:17423643

  20. Progress toward high-Q perfect absorption: A Fano antilaser

    NASA Astrophysics Data System (ADS)

    Yu, Sunkyu; Piao, Xianji; Hong, Jiho; Park, Namkyoo

    2015-07-01

    Here we propose a route to the high-Q perfect absorption of light by introducing the concept of a Fano antilaser. Based on the drastic spectral variation of the optical phase in a Fano-resonant system, a spectral singularity for scatter-free perfect absorption can be achieved with an order of magnitude smaller material loss. By applying temporal coupled mode theory to a Fano-resonant waveguide platform, we reveal that the required material loss and following absorption Q factor are ultimately determined by the degree of Fano spectral asymmetry. The feasibility of the Fano antilaser is confirmed using a photonic crystal platform, to demonstrate spatiospectrally selective heating. Our results utilizing the phase-dependent control of device bandwidths derive a counterintuitive realization of high-Q perfect conversion of light into internal energy, and thus pave the way for a new regime of absorption-based devices, including switches, sensors, thermal imaging, and optothermal emitters.

  1. Photovoltaic device

    DOEpatents

    Reese, Jason A.; Keenihan, James R.; Gaston, Ryan S.; Kauffmann, Keith L.; Langmaid, Joseph A.; Lopez, Leonardo C.; Maak, Kevin D.; Mills, Michael E.; Ramesh, Narayan; Teli, Samar R.

    2015-06-02

    The present invention is premised upon an improved photovoltaic device ("PV device"), more particularly to an improved photovoltaic device with a multilayered photovoltaic cell assembly and a body portion joined at an interface region and including an intermediate layer, at least one interconnecting structural member, relieving feature, unique component geometry, or any combination thereof.

  2. Photovoltaic device

    SciTech Connect

    Reese, Jason A.; Keenihan, James R.; Gaston, Ryan S.; Kauffmann, Keith L.; Langmaid, Joseph A.; Lopez, Leonardo C.; Maak, Kevin D.; Mills, Michael E.; Ramesh, Narayan; Teli, Samar R.

    2015-09-01

    The present invention is premised upon an improved photovoltaic device ("PV device"), more particularly to an improved photovoltaic device (10) with a multilayered photovoltaic cell assembly (100) and a body portion (200) joined at an interface region (410) and including an intermediate layer (500), at least one interconnecting structural member (1500), relieving feature (2500), unique component geometry, or any combination thereof.

  3. THE Q-BIOTYPE WHITEFLY

    Technology Transfer Automated Retrieval System (TEKTRAN)

    In 2004, the Q-biotype of the sweetpotato whitefly, Bemisia tabaci, was identified in the U.S. for the first time. The level of insecticide resistance to pyriproxyfen (Distance) and imidacloprid (Marathon) of the Q-biotype was higher than any U.S. population of B-biotype whiteflies (silverleaf white...

  4. Comparative Efficacy of the Air-Q Intubating Laryngeal Airway during General Anesthesia in Pediatric Patients: A Systematic Review and Meta-Analysis

    PubMed Central

    Ahn, Eun Jin; Choi, Geun Joo; Kang, Hyun; Baek, Chong Wha; Jung, Yong Hun; Woo, Young Cheol; Bang, Si Ra

    2016-01-01

    Air-Q® (air-Q) is a supraglottic airway device which can be used as a guidance of intubation in pediatric as well as in adult patients. We evaluated the efficacy and safety of air-Q compared to other airway devices during general anesthesia in pediatric patients by conducting a systematic review and meta-analysis. A total of 10 studies including 789 patients were included in the final analysis. Compared with other supraglottic airway devices, air-Q showed no evidence for a difference in leakage pressure and insertion time. The ease of insertion was significantly lower than other supraglottic airway devices. The success rate of intubation was significantly lower than other airway devices. However, fiberoptic view was better through the air-Q than other supraglottic airway devices. Therefore, air-Q could be a safe substitute for other airway devices and may provide better fiberoptic bronchoscopic view. PMID:27419134

  5. q-quaternions and q-deformed su(2) instantons

    SciTech Connect

    Fiore, Gaetano

    2007-10-15

    We construct (anti-)instanton solutions of a would-be q-deformed su(2) Yang-Mills theory on the quantum Euclidean space R{sub q}{sup 4} [the SO{sub q}(4)-covariant noncommutative space] by reinterpreting the function algebra on the latter as a q-quaternion bialgebra. Since the (anti-)self-duality equations are covariant under the quantum group of deformed rotations, translations, and scale change, by applying the latter we can generate new solutions from the one centered at the origin and with unit size. We also construct multi-instanton solutions. As they depend on noncommuting parameters playing the roles of 'sizes' and 'coordinates of the centers' of the instantons, this indicates that the moduli space of a complete theory should be a noncommutative manifold. Similarly, gauge transformations should be allowed to depend on additional noncommutative parameters.

  6. Deletion (11)(q14.1q21)

    SciTech Connect

    Stratton, R.F.; Lazarus, K.H.; Ritchie, E.J.L.; Bell, A.M.

    1994-02-01

    The authors report on a 4-year-old girl with moderate development delay, horseshoe kidney, bilateral duplication of the ureters with right upper pole obstruction, hydronephrosis and nonfunction, and subsequent Wilms tumor of the right lower pole. She had an interstitial deletion of the long arm of chromosome 11 involving the region 11(q14.1q21). 22 refs., 2 figs., 1 tab.

  7. Microfluidic Device

    NASA Technical Reports Server (NTRS)

    Tai, Yu-Chong (Inventor); Zheng, Siyang (Inventor); Lin, Jeffrey Chun-Hui (Inventor); Kasdan, Harvey (Inventor)

    2015-01-01

    Described herein are particular embodiments relating to a microfluidic device that may be utilized for cell sensing, counting, and/or sorting. Particular aspects relate to a microfabricated device that is capable of differentiating single cell types from dense cell populations. One particular embodiment relates a device and methods of using the same for sensing, counting, and/or sorting leukocytes from whole, undiluted blood samples.

  8. Microfluidic Device

    NASA Technical Reports Server (NTRS)

    Tai, Yu-Chong (Inventor); Zheng, Siyang (Inventor); Lin, Jeffrey Chun-Hui (Inventor); Kasdan, Harvey L. (Inventor)

    2016-01-01

    Described herein are particular embodiments relating to a microfluidic device that may be utilized for cell sensing, counting, and/or sorting. Particular aspects relate to a microfabricated device that is capable of differentiating single cell types from dense cell populations. One particular embodiment relates a device and methods of using the same for sensing, counting, and/or sorting leukocytes from whole, undiluted blood samples.

  9. Sealing device

    SciTech Connect

    Garcia-Crespo, Andres Jose

    2013-12-10

    A sealing device for sealing a gap between a dovetail of a bucket assembly and a rotor wheel is disclosed. The sealing device includes a cover plate configured to cover the gap and a retention member protruding from the cover plate and configured to engage the dovetail. The sealing device provides a seal against the gap when the bucket assemply is subjected to a centrifugal force.

  10. Sigma model Q-balls and Q-stars

    SciTech Connect

    Verbin, Y.

    2007-10-15

    A new kind of Q-balls is found: Q-balls in a nonlinear sigma model. Their main properties are presented together with those of their self-gravitating generalization, sigma model Q-stars. A simple special limit of solutions which are bound by gravity alone ('sigma stars') is also discussed briefly. The analysis is based on calculating the mass, global U(1) charge and binding energy for families of solutions parametrized by the central value of the scalar field. Two kinds (differing by the potential term) of the new sigma model Q-balls and Q-stars are analyzed. They are found to share some characteristics while differing in other respects like their properties for weak central scalar fields which depend strongly on the form of the potential term. They are also compared with their ordinary counterparts and although similar in some respects, significant differences are found like the existence of an upper bound on the central scalar field. A special subset of the sigma model Q-stars contains those which do not possess a flat space limit. Their relation with sigma star solutions is discussed.

  11. Q Fever in French Guiana

    PubMed Central

    Eldin, Carole; Mahamat, Aba; Demar, Magalie; Abboud, Philippe; Djossou, Félix; Raoult, Didier

    2014-01-01

    Coxiella burnetii, the causative agent of Q fever, is present worldwide. Recent studies have shown that this bacterium is an emerging pathogen in French Guiana and has a high prevalence (24% of community-acquired pneumonia). In this review, we focus on the peculiar epidemiology of Q fever in French Guiana. We place it in the context of the epidemiology of the disease in the surrounding countries of South America. We also review the clinical features of Q fever in this region, which has severe initial presentation but low mortality rates. These characteristics seem to be linked to a unique genotype (genotype 17). Finally, we discuss the issue of the animal reservoir of C. burnetii in French Guiana, which is still unknown. Further studies are necessary to identify this reservoir. Identification of this reservoir will improve the understanding of the Q fever epidemic in French Guiana and will provide new tools to control this public health problem. PMID:25092817

  12. Q (Alpha) Function and Squeezing Effect

    NASA Technical Reports Server (NTRS)

    Yunjie, Xia; Xianghe, Kong; Kezhu, Yan; Wanping, Chen

    1996-01-01

    The relation of squeezing and Q(alpha) function is discussed in this paper. By means of Q function, the squeezing of field with gaussian Q(alpha) function or negative P(a)function is also discussed in detail.

  13. Applications and Methods of Operating a Three-dimensional Nano-electro-mechanical Resonator and Related Devices

    NASA Technical Reports Server (NTRS)

    Kaul, Anupama B. (Inventor); Epp, Larry W. (Inventor); Bagge, Leif (Inventor)

    2013-01-01

    Carbon nanofiber resonator devices, methods for use, and applications of said devices are disclosed. Carbon nanofiber resonator devices can be utilized in or as high Q resonators. Resonant frequency of these devices is a function of configuration of various conducting components within these devices. Such devices can find use, for example, in filtering and chemical detection.

  14. Decoding Gαq signaling.

    PubMed

    Litosch, Irene

    2016-05-01

    q signals with phospholipase C-β (PLC-β) to modify behavior in response to an agonist-bound GPCR. While the fundamental steps which prime Gαq to interact with PLC-β have been identified, questions remain concerning signal strength with PLC-β and other effectors. Gαq is generally viewed to function as a simple ON and OFF switch for its effector, dependent on the binding of GTP or GDP. However, Gαq does not have a single effector, Gαq has many different effectors. Furthermore, select effectors also regulate Gαq activity. PLC-β is a lipase and a GTPase activating protein (GAP) selective for Gαq. The contribution of G protein regulating activity to signal amplitude remains unclear. The unique PLC-β coiled-coil domain is essential for maximum Gαq response, both lipase and GAP. Nonetheless, coiled-coil domain associations necessary to maximum response have not been revealed by the structural approach. This review discusses progress towards understanding the basis for signal strength with PLC-β and other effectors. Shared and effector-specific interactions have been identified. Finally, the evidence for allosteric regulation of lipase stimulation by protein kinase C, the membrane, phosphatidic acid, phosphatidylinositol-4, 5-bisphosphate and GPCR is explored. Endogenous allosteric regulators can suppress or enhance maximum lipase stimulation dependent on the PLC-β coiled-coil domain. A better understanding of allosteric modulation may therefore identify a wealth of new targets to regulate signal strength and behavior. PMID:27012764

  15. Electrochromic devices

    DOEpatents

    Allemand, Pierre M.; Grimes, Randall F.; Ingle, Andrew R.; Cronin, John P.; Kennedy, Steve R.; Agrawal, Anoop; Boulton, Jonathan M.

    2001-01-01

    An electrochromic device is disclosed having a selective ion transport layer which separates an electrochemically active material from an electrolyte containing a redox active material. The devices are particularly useful as large area architectural and automotive glazings due to there reduced back reaction.

  16. BRAKE DEVICE

    DOEpatents

    O'Donnell, T.J.

    1959-03-10

    A brake device is described for utilization in connection with a control rod. The device comprises a pair of parallelogram link mechanisms, a control rod moveable rectilinearly therebetween in opposite directions, and shoes resiliently supported by the mechanism for frictional engagement with the control rod.

  17. PLASMA DEVICE

    DOEpatents

    Gow, J.D.; Wilcox, J.M.

    1961-12-26

    A device is designed for producing and confining highenergy plasma from which neutrons are generated in copious quantities. A rotating sheath of electrons is established in a radial electric field and axial magnetic field produced within the device. The electron sheath serves as a strong ionizing medium to gas introdueed thereto and also functions as an extremely effective heating mechanism to the resulting plasma. In addition, improved confinement of the plasma is obtained by ring magnetic mirror fields produced at the ends of the device. Such ring mirror fields are defined by the magnetic field lines at the ends of the device diverging radially outward from the axis of the device and thereafter converging at spatial annular surfaces disposed concentrically thereabout. (AFC)

  18. Interstitial deletions 4q21.1q25 and 4q25q27: Phenotypic variability and relation to Rieger anomaly

    SciTech Connect

    Kulharya, A.S.; Schneider, N.R.; Tonk, V.

    1995-01-16

    We describe clinical and chromosomal findings in two patients with del(4q). Patient 1, with interstitial deletion (4)(q21.1q25), had craniofacial and skeletal anomalies and died at 8 months hydrocephalus. Patient 2, with interstitial deletion (4)(q25q27), had craniofacial and skeletal anomalies with congenital hypotonia and developmental delay. These patients shared certain manifestations with other del(4q) patients but did not have Rieger anomaly. Clinical variability among patients with interstitial deletions of 4q may be related to variable expression, variable deletion, or imprinting of genes within the 4q region. 15 refs., 4 figs., 1 tab.

  19. Gas sensing with acoustic devices

    SciTech Connect

    Martin, S.J.; Frye, G.C.; Spates, J.J.; Butler, M.A.

    1996-12-31

    A survey is made of acoustic devices that are suitable as gas and vapor sensors. This survey focuses on attributes such as operating frequency, mass sensitivity, quality factor (Q), and their ability to be fabricated on a semiconductor substrate to allow integration with electronic circuitry. The treatment of the device surface with chemically-sensitive films to detect species of interest is discussed. Strategies for improving discrimination are described, including sensor arrays and species concentration and separation schemes. The advantages and disadvantages of integrating sensors with microelectronics are considered, along with the effect on sensitivity of scaling acoustic gas sensors to smaller size.

  20. RF system calibration for global Q matrix determination.

    PubMed

    Padormo, Francesco; Beqiri, Arian; Malik, Shaihan J; Hajnal, Joseph V

    2016-06-01

    The use of multiple transmission channels (known as Parallel Transmission, or PTx) provides increased control of the MRI signal formation process. This extra flexibility comes at a cost of uncertainty of the power deposited in the patient under examination: the electric fields produced by each transmitter can interfere in such a way to lead to excessively high heating. Although it is not possible to determine local heating, the global Q matrix (which allows the whole-body Specific Absorption Rate (SAR) to be known for any PTx pulse) can be measured in-situ by monitoring the power incident upon and reflected by each transmit element during transmission. Recent observations have shown that measured global Q matrices can be corrupted by losses between the coil array and location of power measurement. In this work we demonstrate that these losses can be accounted for, allowing accurate global Q matrix measurement independent of the location of the power measurement devices. PMID:26747407

  1. RF system calibration for global Q matrix determination

    PubMed Central

    Padormo, Francesco; Beqiri, Arian; Malik, Shaihan J.; Hajnal, Joseph V.

    2016-01-01

    The use of multiple transmission channels (known as Parallel Transmission, or PTx) provides increased control of the MRI signal formation process. This extra flexibility comes at a cost of uncertainty of the power deposited in the patient under examination: the electric fields produced by each transmitter can interfere in such a way to lead to excessively high heating. Although it is not possible to determine local heating, the global Q matrix (which allows the whole-body Specific Absorption Rate (SAR) to be known for any PTx pulse) can be measured in-situ by monitoring the power incident upon and reflected by each transmit element during transmission. Recent observations have shown that measured global Q matrices can be corrupted by losses between the coil array and location of power measurement. In this work we demonstrate that these losses can be accounted for, allowing accurate global Q matrix measurement independent of the location of the power measurement devices. PMID:26747407

  2. A new look at q-exponential distributions via excess statistics

    NASA Astrophysics Data System (ADS)

    Bercher, J.-F.; Vignat, C.

    2008-09-01

    Q-exponential distributions play an important role in nonextensive statistics. They appear as the canonical distributions, i.e. the maximum generalized q-entropy distributions under mean constraint. Their relevance is also independently justified by their appearance in the theory of superstatistics introduced by Beck and Cohen. In this paper, we provide a third and independent rationale for these distributions. We indicate that q-exponentials are stable by a statistical normalization operation, and that Pickands’ extreme values theorem plays the role of a CLT-like theorem in this context. This suggests that q-exponentials can arise in many contexts if the system at hand or the measurement device introduces some threshold. Moreover we give an asymptotic connection between excess distributions and maximum q-entropy. We also highlight the role of Generalized Pareto Distributions in many applications and present several methods for the practical estimation of q-exponential parameters.

  3. Gripping device

    NASA Technical Reports Server (NTRS)

    Parma, George F. (Inventor)

    1989-01-01

    This invention relates to a gripping device, and more particularly to one with a large moment carrying capability for handling long workpieces of various diameters and which can be particularly used as an end effector on a robotic arm.

  4. Assistive Devices

    MedlinePlus

    ... center provides information on VA benefits for assistive technology. Medicare − Benefits may include assistive devices, such as ... a Web site that provides information about assistive technology products. Go to the “Products” section to find ...

  5. Device Performance

    SciTech Connect

    Not Available

    2006-06-01

    In the Device Performance group, within the National Center for Photovoltaic's Measurements and Characterization Division, we measure the performance of PV cells and modules with respect to standard reporting conditions--defined as a reference temperature (25 C), total irradiance (1000 Wm-2), and spectral irradiance distribution (IEC standard 60904-3). Typically, these are ''global'' reference conditions, but we can measure with respect to any reference set. To determine device performance, we conduct two general categories of measurements: spectral responsivity (SR) and current versus voltage (I-V). We usually perform these measurements using standard procedures, but we develop new procedures when required by new technologies. We also serve as an independent facility for verifying device performance for the entire PV community. We help the PV community solve its special measurement problems, giving advice on solar simulation, instrumentation for I-V measurements, reference cells, measurement procedures, and anomalous results. And we collaborate with researchers to analyze devices and materials.

  6. Analysis of Q burst waveforms

    NASA Astrophysics Data System (ADS)

    Ogawa, Toshio; Komatsu, Masayuki

    2007-04-01

    The electric field changes in ELF to VLF were observed with a ball antenna in fair weather at Kochi (latitude 33.3°N, longitude 133.4°E) during 2003-2004. Some 376 Q bursts were obtained, seven examples of which are analyzed in the present study. The continuous frequency spectra of the Q bursts and the background noises from 1.0 Hz to 11 kHz are compared, and it was found that the Q bursts prevail over the background in the frequency range from 1 to 300 Hz. The surplus is 20 dB (in amplitude) near the fundamental mode frequency. The "W"-type changes found in the initial portion of the Q burst waveforms are interpreted as the combined electromagnetic waveform of direct and antipodal waves from the causative lightning strokes. From the time intervals between the two waves, the source-receiver distances are estimated as far as 19 Mm. The pulses to excite the Schumann resonances in the Q bursts are clearly identified.

  7. Josephson junction Q-spoiler

    DOEpatents

    Clarke, J.; Hilbert, C.; Hahn, E.L.; Sleator, T.

    1986-03-25

    An automatic Q-spoiler comprising at least one Josephson tunnel junction connected in an LC circuit for flow of resonant current therethrough. When in use in a system for detecting the magnetic resonance of a gyromagnetic particle system, a high energy pulse of high frequency energy irradiating the particle system will cause the critical current through the Josephson tunnel junctions to be exceeded, causing the tunnel junctions to act as resistors and thereby damp the ringing of the high-Q detection circuit after the pulse. When the current has damped to below the critical current, the Josephson tunnel junctions revert to their zero-resistance state, restoring the Q of the detection circuit and enabling the low energy magnetic resonance signals to be detected.

  8. Josephson junction Q-spoiler

    DOEpatents

    Clarke, John; Hilbert, Claude; Hahn, Erwin L.; Sleator, Tycho

    1988-01-01

    An automatic Q-spoiler comprising at least one Josephson tunnel junction connected in an LC circuit for flow of resonant current therethrough. When in use in a system for detecting the magnetic resonance of a gyromagnetic particle system, a high energy pulse of high frequency energy irradiating the particle system will cause the critical current through the Josephson tunnel junctions to be exceeded, causing the tunnel junctions to act as resistors and thereby damp the ringing of the high-Q detection circuit after the pulse. When the current has damped to below the critical current, the Josephson tunnel junctions revert to their zero-resistance state, restoring the Q of the detection circuit and enabling the low energy magnetic resonance signals to be detected.

  9. 10 CFR Appendix Q1 to Subpart B of... - Uniform Test Method for Measuring the Energy Consumption of Fluorescent Lamp Ballasts

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... devices as specified in subpart C of 47 CFR part 18. 1.5. DC control signal means a direct current (DC... technical standards for consumer RF lighting devices as specified in subpart C of 47 CFR part 18. 1.14. RMS..., App. Q1 Appendix Q1 to Subpart B of Part 430—Uniform Test Method for Measuring the Energy...

  10. 10 CFR Appendix Q1 to Subpart B of... - Uniform Test Method for Measuring the Energy Consumption of Fluorescent Lamp Ballasts

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... devices as specified in subpart C of 47 CFR part 18. 1.5. DC control signal means a direct current (DC... technical standards for consumer RF lighting devices as specified in subpart C of 47 CFR part 18. 1.14. RMS..., App. Q1 Appendix Q1 to Subpart B of Part 430—Uniform Test Method for Measuring the Energy...

  11. Coenzyme q 10 : a review.

    PubMed

    Singh, Deependra; Jain, Vandana; Saraf, Swarnlata; Saraf, S

    2002-10-01

    Ubiquinone or Co Q(10) is essentially a vitamin like substance and is a cofactor of an enzyme. It is an integral part of the memberanes of mitocondria where it is involved in the energy production. It is a nutrient necessary for the function of every cell of the body especially vital organs of the body like heart, liver, brain etc. Studies have shown that coenzyme Q(10) alters the natural history of cardiovascular illness and has the potential of prevention of cardiovascular diseases through the inhibition of LDL cholesterol oxidation by maintenance of optimal cellular and mitochondrial function throughout the ravages of time internal and external stress. PMID:22557086

  12. Monosomy 6q1: Syndrome delineation

    SciTech Connect

    Romie, S.S.; Hartsfield, J.K. Jr.; Sutcliffe, M.J.

    1996-03-15

    We report on a girl with a de novo 6q1 interstitial deletion. To our knowledge, this is the second reported case with a deletion of 6q11-q15. We review the phenotype of monosomy 6q1. Our patient has manifestations similar to others with monosomy 6q1 including mental deficiency, growth retardation, short neck, and minor facila anomalies. 18 refs., 5 figs., 3 tabs.

  13. New multilevel codes over GF(q)

    NASA Technical Reports Server (NTRS)

    Wu, Jiantian; Costello, Daniel J., Jr.

    1992-01-01

    Set partitioning to multi-dimensional signal spaces over GF(q), particularly GF sup q-1(q) and GF sup q (q), and show how to construct both multi-level block codes and multi-level trellis codes over GF(q). Two classes of multi-level (n, k, d) block codes over GF(q) with block length n, number of information symbols k, and minimum distance d sub min greater than or = d, are presented. These two classes of codes use Reed-Solomon codes as component codes. They can be easily decoded as block length q-1 Reed-Solomon codes or block length q or q + 1 extended Reed-Solomon codes using multi-stage decoding. Many of these codes have larger distances than comparable q-ary block codes, as component codes. Low rate q-ary convolutional codes, work error correcting convolutional codes, and binary-to-q-ary convolutional codes can also be used to construct multi-level trellis codes over GF(q) or binary-to-q-ary trellis codes, some of which have better performance than the above block codes. All of the new codes have simple decoding algorithms based on hard decision multi-stage decoding.

  14. PLASMA DEVICE

    DOEpatents

    Baker, W.R.; Brathenahl, A.; Furth, H.P.

    1962-04-10

    A device for producing a confined high temperature plasma is described. In the device the concave inner surface of an outer annular electrode is disposed concentrically about and facing the convex outer face of an inner annular electrode across which electrodes a high potential is applied to produce an electric field there between. Means is provided to create a magnetic field perpendicular to the electric field and a gas is supplied at reduced pressure in the area therebetween. Upon application of the high potential, the gas between the electrodes is ionized, heated, and under the influence of the electric and magnetic fields there is produced a rotating annular plasma disk. The ionized plasma has high dielectric constant properties. The device is useful as a fast discharge rate capacitor, in controlled thermonuclear research, and other high temperature gas applications. (AEC)

  15. Q methodology in health economics.

    PubMed

    Baker, Rachel; Thompson, Carl; Mannion, Russell

    2006-01-01

    The recognition that health economists need to understand the meaning of data if they are to adequately understand research findings which challenge conventional economic theory has led to the growth of qualitative modes of enquiry in health economics. The use of qualitative methods of exploration and description alongside quantitative techniques gives rise to a number of epistemological, ontological and methodological challenges: difficulties in accounting for subjectivity in choices, the need for rigour and transparency in method, and problems of disciplinary acceptability to health economists. Q methodology is introduced as a means of overcoming some of these challenges. We argue that Q offers a means of exploring subjectivity, beliefs and values while retaining the transparency, rigour and mathematical underpinnings of quantitative techniques. The various stages of Q methodological enquiry are outlined alongside potential areas of application in health economics, before discussing the strengths and limitations of the approach. We conclude that Q methodology is a useful addition to economists' methodological armoury and one that merits further consideration and evaluation in the study of health services. PMID:16378531

  16. Q fever in maritime Canada.

    PubMed Central

    Marrie, T. J.; Haldane, E. V.; Noble, M. A.; Faulkner, R. S.; Lee, S. H.; Gough, D.; Meyers, S.; Stewart, J.

    1982-01-01

    Only nine cases of Q fever were recorded in Canada in the 20 years prior to 1978. In the 18 months from August 1979 to January 1981 the disease was diagnosed serologically in six patients from the Maritime provinces. All were epidemiologically unrelated and none had been exposed to animals. Five had pneumonia and one had chronic Q fever with probable prosthetic valve endocarditis. Three of the five pneumonia patients presented with signs and symptoms of an acute lower respiratory tract infection and were indistinguishable clinically from other patients with atypical pneumonias. The other two with pneumonia presented with nonresolving pulmonary infiltrates and complained of decreased energy. Four of the five pneumonia patients responded well to treatment with erythromycin; the fifth required two courses of tetracycline. The patient with chronic Q fever had a large amount of cryoglobulins in his serum and evidence of immune complex disease. These cases indicate that Q fever should be considered as a possible cause of atypical pneumonia in Canada. Images FIG. 1 FIG. 2 FIG. 3 PMID:7074457

  17. Analytical Device

    NASA Technical Reports Server (NTRS)

    1983-01-01

    In the mid 60s under contract with NASA, Dr. Benjamin W. Grunbaum was responsible for the development of an automated electrophoresis device that would work in the weightless environment of space. The device was never used in space but was revived during the mid 70s as a technology utilization project aimed at an automated system for use on Earth. The advanced system became known as the Grunbaum System for electrophoresis. It is a versatile, economical assembly for rapid separation of specific blood proteins in very small quantities, permitting their subsequent identification and quantification.

  18. Medical Device Safety

    MedlinePlus

    ... Vaccines, Blood & Biologics Animal & Veterinary Cosmetics Tobacco Products Medical Devices Home Medical Devices Medical Device Safety Medical Device Safety Share Tweet Linkedin Pin it More sharing ...

  19. Molecular diagnosis of coenzyme Q10 deficiency.

    PubMed

    Yubero, Delia; Montero, Raquel; Armstrong, Judith; Espinós, Carmen; Palau, Francesc; Santos-Ocaña, Carlos; Salviati, Leonardo; Navas, Placido; Artuch, Rafael

    2015-01-01

    Coenzyme Q10 (CoQ) deficiency syndromes comprise a growing number of neurological and extraneurological disorders. Primary-genetic but also secondary CoQ deficiencies have been reported. The biochemical determination of CoQ is a good tool for the rapid identification of CoQ deficiencies but does not allow the selection of candidate genes for molecular diagnosis. Moreover, the metabolic pathway for CoQ synthesis is an intricate and not well-understood process, where a large number of genes are implicated. Thus, only next-generation sequencing techniques (either genetic panels of whole-exome and -genome sequencing) are at present appropriate for a rapid and realistic molecular diagnosis of these syndromes. The potential treatability of CoQ deficiency strongly supports the necessity of a rapid molecular characterization of patients, since primary CoQ deficiencies may respond well to CoQ treatment. PMID:26144946

  20. Q analysis on reflection seismic data

    NASA Astrophysics Data System (ADS)

    Wang, Yanghua

    2004-09-01

    Q analysis refers to the procedure for estimating Q directly from a reflection seismic trace. Conventional Q analysis method compares two seismic wavelets selected from different depth (or time) levels, but picking ``clean'' wavelets without interferences from other wavelet and noise from a reflection seismic trace is really a problem. Therefore, instead of analysing individual wavelets, I perform Q analysis using the Gabor transform spectrum which reveals the frequency content changing with time in a seismic trace. I propose two Q analysis methods based on the attenuation function and compensation function, respectively, each of which may produce a series of average values of Q-1 (inverse Q), averaging between the recording surface (or the water bottom) and the subsurface time samples. But the latter is much more stable than the former one. I then calculate the interval or layered values of Q-1 by a constrained linear inversion, which produces a stable estimation of the interval-Q series.

  1. Cleaning devices

    NASA Technical Reports Server (NTRS)

    Schneider, Horst W. (Inventor)

    1981-01-01

    Cleaning devices are described which include a vacuum cleaner nozzle with a sharp rim for directing incoming air down against the floor; a vacuum cleaner wherein electrostatically charged brushes that brush dirt off a floor, are electrically grounded to remove charges that could tend to hold dirt to the brushes; a vacuum cleaner head having slots that form a pair of counter-rotating vortices, and that includes an outlet that blows a stream of air at the floor region which lies between the vortices; a cleaning device that sweeps a group of brushes against the ground along a first direction, and then sweeps them along the same ground area but in a second direction angled from the first by an amount such as 90.degree., to sweep up particles lying in crevices extending along any direction; a device that gently cleans a surface to remove bacteria for analysis, including an inclined wall along which cleaning fluid flows onto the surface, a vacuum chamber for drawing in the cleaning fluid, and a dividing wall spaced slightly from the surface to separate the fluid source from the vacuum cleaner chamber; and a device for providing pulses of pressured air including a chamber to which pressured air is supplied, a ball that circulates around the chamber to repeatedly close an outlet, and an air source that directs air circumferentially to move the ball around the chamber.

  2. Electrochemical device

    DOEpatents

    Grimes, Patrick G.; Einstein, Harry; Bellows, Richard J.

    1988-01-12

    A tunnel protected electrochemical device features channels fluidically communicating between manifold, tunnels and cells. The channels are designed to provide the most efficient use of auxiliary power. The channels have a greater hydraulic pressure drop and electrical resistance than the manifold. This will provide a design with the optimum auxiliary energy requirements.

  3. Detection device

    DOEpatents

    Smith, Jay E.

    1984-01-01

    The present invention is directed to a detection device comprising: (1) an entrance chamber, (2) a central chamber, and (3) an exit chamber. The central chamber includes an ionizing gas, anode, and means for connecting the anode with an external power supply and pulse counter.

  4. Detection device

    DOEpatents

    Smith, J.E.

    1981-02-27

    The present invention is directed to a detection device comprising: (1) an entrance chamber; (2) a central chamber; and (3) an exit chamber. The central chamber includes an ionizing gas, anode, and means for connecting the anode with an external power supply and pulse counter.

  5. Supersymmetric Q-balls: A numerical study

    SciTech Connect

    Campanelli, L.; Ruggieri, M.

    2008-02-15

    We study numerically a class of nontopological solitons, the Q-balls, arising in a supersymmetric extension of the standard model with low-energy, gauge-mediated symmetry breaking. Taking into account the exact form of the supersymmetric potential giving rise to Q-balls, we find that there is a lower limit on the value of the charge Q in order to make them classically stable: Q > or approx. 5x10{sup 2}Q{sub cr}, where Q{sub cr} is constant depending on the parameters defining the potential and can be in the range 1 < or approx. Q{sub cr} < or approx. 10{sup 8} {sup divide} {sup 16}. If Q is the baryon number, stability with respect to the decay into protons requires Q > or approx. 10{sup 17}Q{sub cr}, while if the gravitino mass is greater then m{sub 3/2} > or approx. 61 MeV, no stable gauge-mediation supersymmetric Q-balls exist. Finally, we find that energy and radius of Q-balls can be parametrized as E{approx}{xi}{sub E}Q{sup 3/4} and R{approx}{xi}{sub R}Q{sup 1/4}, where {xi}{sub E} and {xi}{sub R} are slowly varying functions of the charge.

  6. Q fever--selected issues.

    PubMed

    Bielawska-Drózd, Agata; Cieślik, Piotr; Mirski, Tomasz; Bartoszcze, Michał; Knap, Józef Piotr; Gaweł, Jerzy; Żakowska, Dorota

    2013-01-01

    Q fever is an infectious disease of humans and animals caused by Gram-negative coccobacillus Coxiella burnetii, belonging to the Legionellales order, Coxiellaceae family. The presented study compares selected features of the bacteria genome, including chromosome and plasmids QpH1, QpRS, QpDG and QpDV. The pathomechanism of infection--starting from internalization of the bacteria to its release from infected cell are thoroughly described. The drugs of choice for the treatment of acute Q fever are tetracyclines, macrolides and quinolones. Some other antimicrobials are also active against C. burnetii, namely, telitromycines and tigecyclines (glicylcycline). Q-VAX vaccine induces strong and long-term immunity in humans. Coxevac vaccine for goat and sheep can reduce the number of infections and abortions, as well as decrease the environmental transmission of the pathogen. Using the microarrays technique, about 50 proteins has been identified which could be used in the future for the production of vaccine against Q fever. The routine method of C. burnetii culture is proliferation within cell lines; however, an artificial culture medium has recently been developed. The growth of bacteria in a reduced oxygen (2.5%) atmosphere was obtained after just 6 days. In serology, using the IF method as positive titers, the IgM antibody level >1:64 and IgG antibody level >1:256 (against II phase antigens) has been considered. In molecular diagnostics of C. burnetii infection, the most frequently used method is PCR and its modifications; namely, nested PCR and real time PCR which detect target sequences, such as htpAB and IS1111, chromosome genes (com1), genes specific for different types of plasmids and transposase genes. Although Q fever was diagnosed in Poland in 1956, the data about the occurrence of the disease are incomplete. Comprehensive studies on the current status of Q fever in Poland, with special focus on pathogen reservoirs and vectors, the sources of infection and

  7. Purified and surfactant-free coenzyme Q10-loaded biodegradable nanoparticles.

    PubMed

    Nehilla, Barrett J; Bergkvist, Magnus; Popat, Ketul C; Desai, Tejal A

    2008-02-01

    The intent of this work was to synthesize and comprehensively characterize ubiquinone-loaded, surfactant-free biodegradable poly(lactic-co-glycolic acid) (PLGA) nanoparticles in vitro. Surfactant-free, empty and ubiquinone (CoQ10)-loaded biodegradable nanoparticles were synthesized by nanoprecipitation, and the physicochemical properties of these nanoparticles were analyzed with a variety of techniques. Nanoprecipitation consistently yielded individual, sub-200nm, surfactant-free empty and CoQ10-loaded nanoparticles, where the physical and drug encapsulation characteristics were controlled by varying the formulation parameters. CoQ10 release was sustained for 2 weeks but then plateaued before 100% CoQ10 release. A novel, nondestructive purification protocol involving transient sodium dodecyl sulfate (SDS) adsorption to nanoparticles followed by centrifugation and dialysis was developed to yield purified, surfactant-free, CoQ10-loaded nanoparticles. This protocol permitted removal of unencapsulated CoQ10, prevented centrifugation-induced nanoparticle aggregation and preserved the surfactant-free and drug encapsulation properties of the nanoparticles. These CoQ10-loaded nanoparticles are promising as sustained drug delivery devices due to their extended CoQ10 release. Importantly, a surfactant-free nanoprecipitation procedure is presented that in combination with a novel purification step enables the synthesis of individual and purified CoQ10-loaded nanoparticles. PMID:17692482

  8. Electrochemistry of Q-Graphene

    NASA Astrophysics Data System (ADS)

    Randviir, Edward P.; Brownson, Dale A. C.; Gómez-Mingot, Maria; Kampouris, Dimitrios K.; Iniesta, Jesús; Banks, Craig E.

    2012-09-01

    A newly synthesised type of graphene, Q-Graphene, has been physically and electrochemically characterised with Scanning and Transmission Electron Microscopy (SEM, TEM), X-ray Photoelectron Spectroscopy (XPS) and Cyclic Voltammetry (CV). Interpretation of SEM, TEM and XPS data reveal the material to consist of hollow carbon nanospheres of multi-layer graphene (viz. graphite), which exhibit a total oxygen content of ca. 36.0% (atomic weight via XPS). In addition to the carbon structures present, spherical magnesium oxide particles of <=50 nm in diameter are abundantly present in the sample (ca. 16.2%). Interestingly, although the TEM/SEM images show macroporous carbon structures, Raman spectroscopy shows peaks typically characteristic of graphene, which suggests the material is highly heterogeneous and consists of many types of carbon allotropes. Q-Graphene is electrochemically characterised using both inner-sphere and outer-sphere electrochemical redox probes, namely potassium ferrocyanide(ii), hexaammine-ruthenium(iii) chloride and hexachloroiridate(iii), in addition to the biologically relevant and electroactive analytes, norepinephrine, β-nicotinamide adenine dinucleotide (NADH) and l-ascorbic acid. The electrochemical response of Q-Graphene is benchmarked against edge plane- and basal plane-pyrolytic graphite (EPPG and BPPG respectively), pristine graphene and graphite alternatives. Q-Graphene is found to exhibit fast electron transfer kinetics, likely due to its high proportion of folded edges and surface defects, exhibiting a response similar to that of EPPG - which exhibits fast electron transfer rates due to the high proportion of edge plane sites it possesses. Furthermore, we demonstrate that the specific oxygen content plays a pivotal role in dictating the observed electrochemical response, which is analyte dependant. Consequently there is potential for this new member of the graphene family to be beneficially utilised in various electrochemical

  9. Ultrahigh Q Bulk Acoustic Wave Cavities at the Quantum Limit

    NASA Astrophysics Data System (ADS)

    Tobar, Michael; Goryachev, Maxim; Ivanov, Eugene; van Kann, Frank; Galliou, Serge

    2015-03-01

    A Fabry-Perot cavity is an optical resonator, which can store photons for milliseconds and enhance interaction between light and matter. The acoustics analogue (phonon trapping), is the Bulk Acoustic Wave device (in thin film or crystal lattice). Measurements provide the ultimate material loss regimes, minimizing clamping losses and achieving record high Q.f products, allowing observation of various loss mechanisms such as Landau-Rumer, phonon-phonon dissipation and Rayleigh phonon scattering, as well as previously non-observed non-linear effects. This presentation will summarize our recent work towards cooling such modes to the ground state and operating the device at the Quantum Limit. This includes the first measurements of the Nyquist noise near at 4K, as well as details on using such devices to test fundamental physics. Funded by ARC Grant No. CE110001013.

  10. Package of a dual-tapered-fiber coupled microsphere resonator with high Q factor

    NASA Astrophysics Data System (ADS)

    Dong, Yongchao; Wang, Keyi; Jin, Xueying

    2015-09-01

    We package a high-quality (Q) factor optical whispering gallery mode (WGM) microsphere resonator side coupled to two tapered fibers without changing the initial coupling conditions, achieving a final Q as high as 2.7×106. The mechanical stability of the coupling system is improved by placing the tapers in contact with the microsphere. The packaged device can be easily sealed in a targeted hermetic box according to different practical applications, which provides long term maintenance of the coupling efficiency and high-Q factor. Moreover, we test the temperature dependence of the packaged device and demonstrate its capability for thermal tuning of the drop wavelength. This device has a variety of advantages, such as portability, low-cost, and ease of fabrication.

  11. Electrochemistry of Q-graphene.

    PubMed

    Randviir, Edward P; Brownson, Dale A C; Gómez-Mingot, Maria; Kampouris, Dimitrios K; Iniesta, Jesús; Banks, Craig E

    2012-10-21

    A newly synthesised type of graphene, Q-Graphene, has been physically and electrochemically characterised with Scanning and Transmission Electron Microscopy (SEM, TEM), X-ray Photoelectron Spectroscopy (XPS) and Cyclic Voltammetry (CV). Interpretation of SEM, TEM and XPS data reveal the material to consist of hollow carbon nanospheres of multi-layer graphene (viz. graphite), which exhibit a total oxygen content of ca. 36.0% (atomic weight via XPS). In addition to the carbon structures present, spherical magnesium oxide particles of ≤50 nm in diameter are abundantly present in the sample (ca. 16.2%). Interestingly, although the TEM/SEM images show macroporous carbon structures, Raman spectroscopy shows peaks typically characteristic of graphene, which suggests the material is highly heterogeneous and consists of many types of carbon allotropes. Q-Graphene is electrochemically characterised using both inner-sphere and outer-sphere electrochemical redox probes, namely potassium ferrocyanide(II), hexaammine-ruthenium(III) chloride and hexachloroiridate(III), in addition to the biologically relevant and electroactive analytes, norepinephrine, β-nicotinamide adenine dinucleotide (NADH) and l-ascorbic acid. The electrochemical response of Q-Graphene is benchmarked against edge plane- and basal plane-pyrolytic graphite (EPPG and BPPG respectively), pristine graphene and graphite alternatives. Q-Graphene is found to exhibit fast electron transfer kinetics, likely due to its high proportion of folded edges and surface defects, exhibiting a response similar to that of EPPG - which exhibits fast electron transfer rates due to the high proportion of edge plane sites it possesses. Furthermore, we demonstrate that the specific oxygen content plays a pivotal role in dictating the observed electrochemical response, which is analyte dependant. Consequently there is potential for this new member of the graphene family to be beneficially utilised in various electrochemical

  12. Nonlinear q-voter model.

    PubMed

    Castellano, Claudio; Muñoz, Miguel A; Pastor-Satorras, Romualdo

    2009-10-01

    We introduce a nonlinear variant of the voter model, the q-voter model, in which q neighbors (with possible repetition) are consulted for a voter to change opinion. If the q neighbors agree, the voter takes their opinion; if they do not have a unanimous opinion, still a voter can flip its state with probability epsilon . We solve the model on a fully connected network (i.e., in mean field) and compute the exit probability as well as the average time to reach consensus by employing the backward Fokker-Planck formalism and scaling arguments. We analyze the results in the perspective of a recently proposed Langevin equation aimed at describing generic phase transitions in systems with two ( Z2-symmetric) absorbing states. In particular, by deriving explicitly the coefficients of such a Langevin equation as a function of the microscopic flipping probabilities, we find that in mean field the q-voter model exhibits a disordered phase for high epsilon and an ordered one for low epsilon with three possible ways to go from one to the other: (i) a unique (generalized-voter-like) transition, (ii) a series of two consecutive transitions, one (Ising-like) in which the Z2 symmetry is broken and a separate one (in the directed-percolation class) in which the system falls into an absorbing state, and (iii) a series of two transitions, including an intermediate regime in which the final state depends on initial conditions. This third (so far unexplored) scenario, in which a type of ordering dynamics emerges, is rationalized and found to be specific of mean field, i.e., fluctuations are explicitly shown to wash it out in spatially extended systems. PMID:19905295

  13. Intrauterine devices.

    PubMed

    Burkman, R T

    1991-08-01

    Approximately 60 million women use the intrauterine device (IUD) worldwide; however, owing primarily to nonmedical reasons, the IUD is far less popular in the United States. Although the contraceptive mechanism of action is unknown, it appears that spermicidal activity may be important. Overall, the efficacy of the copper devices is quite good, such that the overall lifespan can probably be extended. Possible pelvic infection remains the greatest potential risk, although in properly selected women the risk is quite low. Use of prophylactic antibiotics at the time of insertion may offer additional protection against this risk. Although IUD users may have more nonspecific vaginal inflammation than do other women, the clinical significance is probably limited. Further, users do not appear to have elevated risks for cervical infections. Although menometrorrhagia persists as a potential problem, the mechanism for such bleeding is not well understood. Finally, the retroflexed uterine position does not appear to increase the risk of abnormal outcomes. PMID:1878504

  14. LOADING DEVICE

    DOEpatents

    Ohlinger, L.A.

    1958-10-01

    A device is presented for loading or charging bodies of fissionable material into a reactor. This device consists of a car, mounted on tracks, into which the fissionable materials may be placed at a remote area, transported to the reactor, and inserted without danger to the operating personnel. The car has mounted on it a heavily shielded magazine for holding a number of the radioactive bodies. The magazine is of a U-shaped configuration and is inclined to the horizontal plane, with a cap covering the elevated open end, and a remotely operated plunger at the lower, closed end. After the fissionable bodies are loaded in the magazine and transported to the reactor, the plunger inserts the body at the lower end of the magazine into the reactor, then is withdrawn, thereby allowing gravity to roll the remaining bodies into position for successive loading in a similar manner.

  15. Laser device

    DOEpatents

    Scott, Jill R.; Tremblay, Paul L.

    2008-08-19

    A laser device includes a virtual source configured to aim laser energy that originates from a true source. The virtual source has a vertical rotational axis during vertical motion of the virtual source and the vertical axis passes through an exit point from which the laser energy emanates independent of virtual source position. The emanating laser energy is collinear with an orientation line. The laser device includes a virtual source manipulation mechanism that positions the virtual source. The manipulation mechanism has a center of lateral pivot approximately coincident with a lateral index and a center of vertical pivot approximately coincident with a vertical index. The vertical index and lateral index intersect at an index origin. The virtual source and manipulation mechanism auto align the orientation line through the index origin during virtual source motion.

  16. Genetics Home Reference: 18q deletion syndrome

    MedlinePlus

    ... Veltman JA, van Ravenswaaij-Arts CM. Genotype-phenotype mapping of chromosome 18q deletions by high-resolution array ... L, Pihko H. 18q deletions: clinical, molecular, and brain MRI findings of 14 individuals. Am J Med ...

  17. Absorption band Q model for the Earth

    NASA Technical Reports Server (NTRS)

    Anderson, D. L.; Given, J. W.

    1981-01-01

    Attenuation in solids and liquids, as measured by the quality factor Q, is typically frequency dependent. In seismology, however, Q is usually assumed to be independent of frequency. Body wave, surface wave, and normal mode data are used to place constraints on the frequency dependence of Q in the mantle. Specific features of the absorption band model are: low-Q in the seismic band at both the top and the base of the mantle, low-Q for long-period body waves in the outer core, an inner core Q sub s that increases with period, and low Q sub p/Q sub s at short periods in the middle mantle.

  18. Q Methodology, Communication, and the Behavioral Text.

    ERIC Educational Resources Information Center

    McKeown, Bruce

    1990-01-01

    Discusses Q methodology in light of modern philosophy of science and hermeneutics. Outlines and discusses the basic steps of conducting Q-method research. Suggests that Q methodology allows researchers to understand and interpret the subjective text of respondents without confounding them with external categories of theoretical reflection. (RS)

  19. First report of Q fever in Oman.

    PubMed Central

    Scrimgeour, E. M.; Johnston, W. J.; Al Dhahry, S. H.; El-Khatim, H. S.; John, V.; Musa, M.

    2000-01-01

    Although serologic evidence suggests the presence of Q fever in humans and animals in Saudi Arabia and the United Arab Emirates, acute Q fever has not been reported on the Arabian Peninsula. We report the first two cases of acute Q fever in Oman. PMID:10653575

  20. Physical findings in 21q22 deletion suggest critical region for 21q - phenotype in q22

    SciTech Connect

    Thedoropoulos, D.S.; Cowan, J.M.; Elias, E.R.; Cole, C.

    1995-11-06

    Multiple abnormalities were observed in a newborn infant with a deletion in the long arm of chromosome 21, from band 22q22.1{yields}qter. The phenotype of this infant was similar to that previously described in infants with deletions spanning the long arm of chromosome 21, from the centromere to 21q22. However, as a phenotypically normal child with normal intelligence and with deletion of 21q11.1-21q21.3 has also been identified, this case suggests that the critical region of deletion for the 21q - phenotype lies distal to 21q21, within 21q22.1-22.2. 10 refs., 2 figs.

  1. Electroexplosive device

    NASA Technical Reports Server (NTRS)

    Menichelli, V. J. (Inventor)

    1978-01-01

    An electroexplosive device is presented which employs a header having contact pins hermetically sealed with glass passing through from a connector end of the header to a cavity filled with a shunt layer of a new nonlinear resistive composition and a heat-sink layer of a new dielectric composition having good thermal conductivity and capacity. The nonlinear resistive layer and the heat-sink layer are prepared from materials by mixing with a low temperature polymerizing resin. The resin is dissolved in a suitable solvent and later evaporated. The resultant solid composite is ground into a powder, press formed into the header and cured (polymerized) at about 250 to 300 F.

  2. Device Connectivity

    PubMed Central

    Walsh, John; Roberts, Ruth; Morris, Richard

    2015-01-01

    Patients with diabetes have to take numerous factors/data into their therapeutic decisions in daily life. Connecting the devices they are using by feeding the data generated into a database/app is supposed to help patients to optimize their glycemic control. As this is not established in practice, the different roadblocks have to be discussed to open the road. That large telecommunication companies are now entering this market might be a big help in pushing this forward. Smartphones offer an ideal platform for connectivity solutions. PMID:25614015

  3. OLED devices

    DOEpatents

    Sapochak, Linda Susan [Arlington, VA; Burrows, Paul Edward [Kennewick, WA; Bimalchandra, Asanga [Richland, WA

    2011-02-22

    An OLED device having an emission layer formed of an ambipolar phosphine oxide host material and a dopant, a hole transport layer in electrical communication with an anode, an electron transport layer in communication with a cathode, wherein the HOMO energy of the hole transport layer is substantially the same as the HOMO energy of the ambipolar host in the emission layer, and the LUMO energy of the electron transport layer is substantially the same as the LUMO energy of the ambipolar host in the emission layer.

  4. Electrospray device

    NASA Technical Reports Server (NTRS)

    Demmons, Nathaniel (Inventor); Martin, Roy (Inventor); Hruby, Vladimir (Inventor); Roy, Thomas (Inventor); Spence, Douglas (Inventor); Ehrbar, Eric (Inventor); Zwahlen, Jurg (Inventor)

    2011-01-01

    An electrospray device includes an electrospray emitter adapted to receive electrospray fluid; an extractor plate spaced from the electrospray emitter and having at least one aperture; and a power supply for applying a first voltage between the extractor plate and emitter for generating at least one Taylor cone emission through the aperture to create an electrospray plume from the electrospray fluid, the extractor plate as well as accelerator and shaping plates may include a porous, conductive medium for transporting and storing excess, accumulated electrospray fluid away from the aperture.

  5. Electrochromic device

    SciTech Connect

    Schwendemanm, Irina G.; Polcyn, Adam D.; Finley, James J.; Boykin, Cheri M.; Knowles, Julianna M.

    2011-03-15

    An electrochromic device includes a first substrate spaced from a second substrate. A first conductive member is formed over at least a portion of the first substrate. A first electrochromic material is formed over at least a portion of the first conductive member. The first electrochromic material includes an organic material. A second conductive member is formed over at least a portion of the second substrate. A second electrochromic material is formed over at least a portion of the second conductive member. The second electrochromic material includes an inorganic material. An ionic liquid is positioned between the first electrochromic material and the second electrochromic material.

  6. Diversionary device

    DOEpatents

    Grubelich, Mark C.

    2001-01-01

    A diversionary device has a housing having at least one opening and containing a non-explosive propellant and a quantity of fine powder packed within the housing, with the powder being located between the propellant and the opening. When the propellant is activated, it has sufficient energy to propel the powder through the opening to produce a cloud of powder outside the housing. An igniter is also provided for igniting the cloud of powder to create a diversionary flash and bang, but at a low enough pressure to avoid injuring nearby people.

  7. Status of the 2Q-LEBT facility at ANL.

    SciTech Connect

    Scott, R. H.; Asseev, V. N.; Kulevoy, T. V.; Ostroumov, P. N.; Poklonskaya, E. A.; Sengupta, M.; Vinogradov, N. E.; Physics; ITEP; St. Petersburg Electrochemical Univ.; Northern Illinois Univ.

    2007-07-01

    The concept for a 2 charge state injector for a 'RIA type' accelerator has been presented. Progress toward an operational prototype 2Q-LEBT system at Argonne National Laboratory (ANL) is under way. The existing BIE 100 all permanent magnet ECR has been placed on a high voltage platform capable of a combined >100kV with q/m separation at ground level. Remote control of the devices on the platform has been implemented. Other components of the facility are currently being tested. The components of an achromatic bending system are currently being procured. This paper will present recent work at the facility as well as preliminary development of solid materials using the BIE 100.

  8. Air-Q laryngeal airway for rescue and tracheal intubation.

    PubMed

    Ads, Ayman; Auerbach, Frederic; Ryan, Kelly; El-Ganzouri, Abdel R

    2016-08-01

    We report the successful use of the Air-Q laryngeal airway (Air-Q LA) as a ventilatory device and a conduit for tracheal intubation to rescue the airway in a patient with difficult airway and tracheal stenosis. This is the first case report of the device to secure the airway after two episodes of hypoxemia in the operating room and intensive care unit. Consent for submission of this case report was obtained from our institution's human studies institutional review board given that the patient died a few months after his discharge from the hospital before his personal consent could be obtained and before preparation of this report. All personal identifiers that could lead to his identification have been removed from this report. A 59-year-old man was scheduled for a flexible and rigid bronchoscopy with possible laser excision of tracheal stenosis. He had a history of hypertension, atrial fibrillation, and diabetes. Assessment of airway revealed a thyromental distance of 6.5 cm, Mallampati class II, and body weight of 110 kg. He had hoarseness and audible inspiratory/expiratory stridor with Spo2 90% breathing room air. After induction and muscle relaxation, tracheal intubation and flexible bronchoscopy were achieved without incident. The patient was then extubated and a rigid bronchoscopy was attempted but failed with Spo2 dropping to 92%; rocuronium 60 mg was given, and reintubation was accomplished with a 7.5-mm endotracheal tube. A second rigid bronchoscopy attempt failed, with Spo2 dropping to 63%. Subsequent direct laryngoscopy revealed a bloody hypopharynx. A size 4.5 Air-Q LA was placed successfully and confirmed with capnography, and Spo2 returned to 100%. The airway was suctioned through the Air-Q LA device, and the airway was secured using a fiberoptic bronchoscope to place an endotracheal tube of 7.5-mm internal diameter. The case was canceled because of edema of the upper airway from multiple attempts with rigid bronchoscopy. The patient was transported

  9. q-entropy for symbolic dynamical systems

    NASA Astrophysics Data System (ADS)

    Zhao, Yun; Pesin, Yakov

    2015-12-01

    For symbolic dynamical systems we use the Carathéodory construction as described in (Pesin 1997 Dimension Theory in Dynamical Systems, ConTemporary Views and Applications (Chicago: University of Chicago Press)) to introduce the notions of q-topological and q-metric entropies. We describe some basic properties of these entropies and in particular, discuss relations between q-metric entropy and local metric entropy. Both q-topological and q-metric entropies are new invariants respectively under homeomorphisms and metric isomorphisms of dynamical systems.

  10. Fate of thermal log type Q balls

    SciTech Connect

    Chiba, Takeshi; Kamada, Kohei; Kasuya, Shinta; Yamaguchi, Masahide

    2010-11-15

    We study time evolution of the Q ball in thermal logarithmic potential using lattice simulations. As the temperature decreases due to the cosmic expansion, the thermal logarithmic term in the potential is eventually overcome by a mass term, and we confirm that the Q ball transforms from the thick-wall type to the thin-wall type for a positive coefficient of radiative corrections to the mass term, as recently suggested. Moreover, we find that the Q ball finally ''melts down'' when the Q-ball solution disappears. We also discuss the effects of this phenomenon on the detectability of gravitational waves from the Q-ball formation.

  11. High-Q contacted ring microcavities with scatterer-avoiding “wiggler” Bloch wave supermode fields

    SciTech Connect

    Liu, Yangyang Popović, Miloš A.

    2014-05-19

    High-Q ring resonators with contacts to the waveguide core provide a versatile platform for various applications in chip-scale optomechanics, thermo-, and electro-optics. We propose and demonstrate azimuthally periodic contacted ring resonators based on multi-mode Bloch matching that support contacts on both the inner and outer radius edges with small degradation to the optical quality factor (Q). Radiative coupling between degenerate modes of adjacent radial spatial order leads to imaginary frequency (Q) splitting and a scatterer avoiding high-Q “wiggler” supermode field. We experimentally measure Qs up to 258 000 in devices fabricated in a silicon device layer on buried oxide undercladding and up to 139 000 in devices fully suspended in air using an undercut step. Wiggler supermodes are true modes of the microphotonic system that offer additional degrees of freedom in electrical, thermal, and mechanical design.

  12. Recent Advances in the 5q- Syndrome

    PubMed Central

    Pellagatti, Andrea; Boultwood, Jacqueline

    2015-01-01

    The 5q- syndrome is the most distinct of the myelodysplastic syndromes (MDS) and patients with this disorder have a deletion of chromosome 5q [del(5q)] as the sole karyotypic abnormality. Several genes mapping to the commonly deleted region of the 5q- syndrome have been implicated in disease pathogenesis in recent years. Haploinsufficiency of the ribosomal gene RPS14 has been shown to cause the erythroid defect in the 5q- syndrome. Loss of the microRNA genes miR-145 and miR-146a has been associated with the thrombocytosis observed in 5q- syndrome patients. Haploinsufficiency of CSNK1A1 leads to hematopoietic stem cell expansion in mice and may play a role in the initial clonal expansion in patients with 5q- syndrome. Moreover, a subset of patients harbor mutation of the remaining CSNK1A1 allele. Mouse models of the 5q- syndrome, which recapitulate the key features of the human disease, indicate that a p53-dependent mechanism underlies the pathophysiology of this disorder. Importantly, activation of p53 has been demonstrated in the human 5q- syndrome. Recurrent TP53 mutations have been associated with an increased risk of disease evolution and with decreased response to the drug lenalidomide in del(5q) MDS patients. Potential new therapeutic agents for del(5q) MDS include the translation enhancer L-leucine. PMID:26075044

  13. Q fever in Bulgaria and Slovakia.

    PubMed Central

    Serbezov, V. S.; Kazár, J.; Novkirishki, V.; Gatcheva, N.; Kovácová, E.; Voynova, V.

    1999-01-01

    As a result of dramatic political and economic changes in the beginning of the 1990s, Q-fever epidemiology in Bulgaria has changed. The number of goats almost tripled; contact between goat owners (and their families) and goats, as well as goats and other animals, increased; consumption of raw goat milk and its products increased; and goats replaced cattle and sheep as the main source of human Coxiella burnetii infections. Hundreds of overt, serologically confirmed human cases of acute Q fever have occurred. Chronic forms of Q fever manifesting as endocarditis were also observed. In contrast, in Slovakia, Q fever does not pose a serious public health problem, and the chronic form of infection has not been found either in follow-ups of a Q-fever epidemic connected with goats imported from Bulgaria and other previous Q-fever outbreaks or in a serologic survey. Serologic diagnosis as well as control and prevention of Q fever are discussed. PMID:10341175

  14. High Q BPS Monopole Bags are Urchins

    NASA Astrophysics Data System (ADS)

    Evslin, Jarah; Gudnason, Sven Bjarke

    2014-01-01

    It has been known for 30 years that 't Hooft-Polyakov monopoles of charge Q greater than one cannot be spherically symmetric. Five years ago, Bolognesi conjectured that, at some point in their moduli space, BPS monopoles can become approximately spherically symmetric in the high Q limit. In this paper, we determine the sense in which this conjecture is correct. We consider an SU(2) gauge theory with an adjoint scalar field, and numerically find configurations with Q units of magnetic charge and a mass which is roughly linear in Q, for example, in the case Q = 81 we present a configuration whose energy exceeds the BPS bound by about 54%. These approximate solutions are constructed by gluing together Q cones, each of which contains a single unit of magnetic charge. In each cone, the energy is largest in the core, and so a constant energy density surface contains Q peaks and thus resembles a sea urchin.

  15. Neuroblastoma in a boy with MCA/MR syndrome, deletion 11q, and duplication 12q

    SciTech Connect

    Koiffmann, C.P.; Vianna-Morgante, A.M.; Wajntal, A.

    1995-07-31

    Deletion 11q23{r_arrow}qter and duplication 12q23{r_arrow}qter are described in a boy with neuroblastoma, multiple congenital anomalies, and mental retardation. The patient has clinical manifestations of 11q deletion and 12q duplication syndromes. The possible involvement of the segment 11q23{r_arrow}24 in the cause of the neuroblastoma is discussed. 18 refs., 2 figs., 1 tab.

  16. Autoantibodies against complement C1q specifically target C1q bound on early apoptotic cells.

    PubMed

    Bigler, Cornelia; Schaller, Monica; Perahud, Iryna; Osthoff, Michael; Trendelenburg, Marten

    2009-09-01

    Autoantibodies against complement C1q (anti-C1q) are frequently found in patients with systemic lupus erythematosus (SLE). They strongly correlate with the occurrence of severe lupus nephritis, suggesting a pathogenic role in SLE. Because anti-C1q are known to recognize a neoepitope on bound C1q, but not on fluid-phase C1q, the aim of this study was to clarify the origin of anti-C1q by determining the mechanism that renders C1q antigenic. We investigated anti-C1q from serum and purified total IgG of patients with SLE and hypocomplementemic urticarial vasculitis as well as two monoclonal human anti-C1q Fab from a SLE patient generated by phage display. Binding characteristics, such as their ability to recognize C1q bound on different classes of Igs, on immune complexes, and on cells undergoing apoptosis, were analyzed. Interestingly, anti-C1q did not bind to C1q bound on Igs or immune complexes. Neither did we observe specific binding of anti-C1q to C1q bound on late apoptotic/necrotic cells when compared with binding in the absence of C1q. However, as shown by FACS analysis and confocal microscopy, anti-C1q specifically targeted C1q bound on early apoptotic cells. Anti-C1q were found to specifically target C1q bound on cells undergoing apoptosis. Our observations suggest that early apoptotic cells are a major target of the autoimmune response in SLE and provide a direct link between human SLE, apoptosis, and C1q. PMID:19648280

  17. Prader-Willi, Angelman, and 15q11-q13 duplication syndromes

    PubMed Central

    2015-01-01

    Three distinct neurodevelopmental disorders arise primarily from deletions or duplications that occur at the 15q11-q13 locus: Prader-Willi syndrome (PWS), Angelman syndrome (AS), and 15q11-q13 duplication syndrome (Dup15q syndrome). Each of these disorders results from the loss of function or over-expression of at least one imprinted gene. Here we discuss the clinical background, genetic etiology, diagnostic strategy, and management for each of these three disorders. PMID:26022164

  18. Maternal uniparental disomy of chromosome 14 in a boy with t(14q14q) associated with a paternal t(13q14q)

    SciTech Connect

    Tomkins, D.J.; Waye, J.S.; Whelan, D.T.

    1994-09-01

    An 11-year-old boy was referred for chromosomal analysis because of precocious development and behavioral problems suggestive of the fragile X syndrome. The cytogenetic fragile X studies were normal, but a routine GTG-banded karyotype revealed an abnormal male karyotype with a Robertsonian translocation between the two chromosome 14`s: 46,XY,t(14q14q). Paternal karyotyping revealed another abnormal karyotype: 46,XY,t(13q14q). A brother had the same karyotype as the father; the mother was deceased. In order to determine if the apparently balanced t(14q14q) in the proband might be the cause of the clinical findings, molecular analysis of the origin of the chromosome 14`s was initiated. Southern blotting and hybridization with D4S13 showed that the proband had two copies of one maternal allele which was shared by his brother. The brother`s second allele corresponded to one of the paternal alleles; the proband had no alleles from the father. Analysis of four other VNTRs demonstrated the probability of paternity to be greater than 99%. Thus, the t(14q14q) was most likely composed of two maternal chromosome 14`s. Further characterization of the t(14q14q) by dinucleotide repeat polymorphic markers is in progress to determine whether it has arisen from maternal isodisomy or heterodisomy. Several cases of uniparental disomy for chromosome 14 have been reported recently. Paternal disomy appears to be associated with more severe congenital anomalies and mental retardation, whereas maternal disomy may be associated with premature puberty and minimal intellectual impairment. The origin of the t(14q14q) in the present case may be related to the paternal translocation, as the segregation of the t(13q14q) in meiosis could lead to sperm that are nullisomic for chromosome 14.

  19. Generation of vector beams at 1550 nm telecommunications wavelength using a segmented q-plate

    NASA Astrophysics Data System (ADS)

    Badham, Katherine; Delaney, Sam; Hashimotono, Nobuyuki; Sánchez-López, María M.; Kurihara, Makoto; Tanabe, Ayano; Moreno, Ignacio; Davis, Jeffrey A.

    2016-03-01

    We present the use of a q-plate device operating at the 1550 nm telecommunications wavelength. A prototype liquid-crystal device from Citizen Holdings Co. is demonstrated to be useful for the generation of vector beams and orbital angular momentum transfer at this important wavelength.

  20. Optoelectronic device

    DOEpatents

    Bonekamp, Jeffrey E.; Boven, Michelle L.; Gaston, Ryan S.

    2014-09-09

    The invention is an optoelectronic device comprising an active portion which converts light to electricity or converts electricity to light, the active portion having a front side for the transmittal of the light and a back side opposite from the front side, at least two electrical leads to the active portion to convey electricity to or from the active portion, an enclosure surrounding the active portion and through which the at least two electrical leads pass wherein the hermetically sealed enclosure comprises at the front side of the active portion a barrier material which allows for transmittal of light, one or more getter materials disposed so as to not impede the transmission of light to or from the active portion, and a contiguous gap pathway to the getter material which pathway is disposed between the active portion and the barrier material.

  1. CLOSURE DEVICE

    DOEpatents

    Linzell, S.M.; Dorcy, D.J.

    1958-08-26

    A quick opening type of stuffing box employing two banks of rotatable shoes, each of which has a caraming action that forces a neoprene sealing surface against a pipe or rod where it passes through a wall is presented. A ring having a handle or wrench attached is placed eccentric to and between the two banks of shoes. Head bolts from the shoes fit into slots in this ring, which are so arranged that when the ring is rotated a quarter turn in one direction the shoes are thrust inwardly to cramp the neopnrene about the pipe, malting a tight seal. Moving the ring in the reverse direction moves the shoes outwardly and frees the pipe which then may be readily removed from the stuffing box. This device has particular application as a closure for the end of a coolant tube of a neutronic reactor.

  2. PLASMA DEVICE

    DOEpatents

    Baker, W.R.

    1961-08-22

    A device is described for establishing and maintaining a high-energy, rotational plasma for use as a fast discharge capacitor. A disc-shaped, current- conducting plasma is formed in an axinl magnetic field and a crossed electric field, thereby creating rotational kinetic enengy in the plasma. Such energy stored in the rotation of the plasma disc is substantial and is convertible tc electrical energy by generator action in an output line electrically coupled to the plasma volume. Means are then provided for discharging the electrical energy into an external circuit coupled to the output line to produce a very large pulse having an extremely rapid rise time in the waveform thereof. (AE C)

  3. Electrophoresis device

    NASA Technical Reports Server (NTRS)

    Rhodes, P. H.; Snyder, R. S. (Inventor)

    1982-01-01

    A device for separating cellular particles of a sample substance into fractionated streams of different cellular species includes a casing having a distribution chamber, a separation chamber, and a collection chamber. The electrode chambers are separated from the separation chamber interior by means of passages such that flow variations and membrane variations around the slotted portion of the electrode chamber do not enduce flow perturbations into the laminar buffer curtain flowing in the separation chamber. The cellular particles of the sample are separated under the influence of the electrical field and the separation chamber into streams of different cellular species. The streams of separated cells enter a partition array in the collection chamber where they are fractionated and collected.

  4. Engineered Carbon Nanotube Materials for High-Q Nanomechanical Resonators

    NASA Technical Reports Server (NTRS)

    Choi, Daniel S.; Hunt, Brian; Bronikowski, Mike; Epp, Larry; Hoenk, Michael; Hoppe, Dan; Kowalczyk, Bob; Wong, Eric; Xu, Jimmy; Adam, Douglas; Young, Rob

    2003-01-01

    This document represents a presentation offered by the Jet Propulsion Laboratory, with assistance from researchers from Brown University and Northrop Grumman. The presentation took place in Seoul, Korea in July 2003 and attempted to demonstrate the fabrication approach regarding the development of high quality factor (high-Q) mechanical oscillators (in the forms of a tunable nanotube resonator and a nanotube array radio frequency [RF] filter) aimed at signal processing and based on carbon nanotubes. The presentation also addressed parallel efforts to develop both in-plane single nanotube resonators as well as vertical array power devices.

  5. Clinical applications of coenzyme Q10.

    PubMed

    Garrido-Maraver, Juan; Cordero, Mario D; Oropesa-Avila, Manuel; Vega, Alejandro Fernandez; de la Mata, Mario; Pavon, Ana Delgado; Alcocer-Gomez, Elisabet; Calero, Carmen Perez; Paz, Marina Villanueva; Alanis, Macarena; de Lavera, Isabel; Cotan, David; Sanchez-Alcazar, Jose A

    2014-01-01

    Coenzyme Q10 (CoQ10) or ubiquinone was known for its key role in mitochondrial bioenergetics as electron and proton carrier; later studies demonstrated its presence in other cellular membranes and in blood plasma, and extensively investigated its antioxidant role. These two functions constitute the basis for supporting the clinical indication of CoQ10. Furthermore, recent data indicate that CoQ10 affects expression of genes involved in human cell signalling, metabolism and transport and some of the effects of CoQ10 supplementation may be due to this property. CoQ10 deficiencies are due to autosomal recessive mutations, mitochondrial diseases, ageing-related oxidative stress and carcinogenesis processes, and also a secondary effect of statin treatment. Many neurodegenerative disorders, diabetes, cancer, fibromyalgia, muscular and cardiovascular diseases have been associated with low CoQ10 levels. CoQ10 treatment does not cause serious adverse effects in humans and new formulations have been developed that increase CoQ10 absorption and tissue distribution. Oral CoQ10 treatment is a frequent mitochondrial energizer and antioxidant strategy in many diseases that may provide a significant symptomatic benefit. PMID:24389208

  6. 22q11 deletion syndrome: current perspective

    PubMed Central

    Hacıhamdioğlu, Bülent; Hacıhamdioğlu, Duygu; Delil, Kenan

    2015-01-01

    Chromosome 22q11 is characterized by the presence of chromosome-specific low-copy repeats or segmental duplications. This region of the chromosome is very unstable and susceptible to mutations. The misalignment of low-copy repeats during nonallelic homologous recombination leads to the deletion of the 22q11.2 region, which results in 22q11 deletion syndrome (22q11DS). The 22q11.2 deletion is associated with a wide variety of phenotypes. The term 22q11DS is an umbrella term that is used to encompass all 22q11.2 deletion-associated phenotypes. The haploinsufficiency of genes located at 22q11.2 affects the early morphogenesis of the pharyngeal arches, heart, skeleton, and brain. TBX1 is the most important gene for 22q11DS. This syndrome can ultimately affect many organs or systems; therefore, it has a very wide phenotypic spectrum. An increasing amount of information is available related to the pathogenesis, clinical phenotypes, and management of this syndrome in recent years. This review summarizes the current clinical and genetic status related to 22q11DS. PMID:26056486

  7. Coenzyme Q supplementation in pulmonary arterial hypertension

    PubMed Central

    Sharp, Jacqueline; Farha, Samar; Park, Margaret M.; Comhair, Suzy A.; Lundgrin, Erika L.; Tang, W.H. Wilson; Bongard, Robert D.; Merker, Marilyn P.; Erzurum, Serpil C.

    2014-01-01

    Mitochondrial dysfunction is a fundamental abnormality in the vascular endothelium and smooth muscle of patients with pulmonary arterial hypertension (PAH). Because coenzyme Q (CoQ) is essential for mitochondrial function and efficient oxygen utilization as the electron carrier in the inner mitochondrial membrane, we hypothesized that CoQ would improve mitochondrial function and benefit PAH patients. To test this, oxidized and reduced levels of CoQ, cardiac function by echocardiogram, mitochondrial functions of heme synthesis and cellular metabolism were evaluated in PAH patients (N=8) in comparison to healthy controls (N=7), at baseline and after 12 weeks oral CoQ supplementation. CoQ levels were similar among PAH and control individuals, and increased in all subjects with CoQ supplementation. PAH patients had higher CoQ levels than controls with supplementation, and a tendency to a higher reduced-to-oxidized CoQ ratio. Cardiac parameters improved with CoQ supplementation, although 6-minute walk distances and BNP levels did not significantly change. Consistent with improved mitochondrial synthetic function, hemoglobin increased and red cell distribution width (RDW) decreased in PAH patients with CoQ, while hemoglobin declined slightly and RDW did not change in healthy controls. In contrast, metabolic and redox parameters, including lactate, pyruvate and reduced or oxidized gluthathione, did not change in PAH patients with CoQ. In summary, CoQ improved hemoglobin and red cell maturation in PAH, but longer studies and/or higher doses with a randomized placebo-controlled controlled design are necessary to evaluate the clinical benefit of this simple nutritional supplement. PMID:25180165

  8. A novel subgroup Q5 of human Y-chromosomal haplogroup Q in India

    PubMed Central

    Sharma, Swarkar; Rai, Ekta; Bhat, Audesh K; Bhanwer, Amarjit S; Bamezai, Rameshwar NK

    2007-01-01

    Background Y-chromosomal haplogroup (Y-HG) Q is suggested to originate in Asia and represent recent founder paternal Native American radiation into the Americas. This group is delineated into Q1, Q2 and Q3 subgroups defined by biallelic markers M120, M25/M143 and M3, respectively. Recently, a novel subgroup Q4 has been identified which is defined by bi-allelic marker M346, representing HG Q (0.41%, 3/728) in Indian population. With scanty details of HG Q in Asia, especially India, it was pertinent to explore the status of the Y-HG Q in Indian population to gather an insight to determine the extent of diversity within this region. Results We observed 15/630 (2.38%) Y-HG Q individuals in India with an ancestral state at M120, M25, M3 and M346 markers, indicating an absence of already known Q1, Q2, Q3 and Q4 sub-haplogroups. Interestingly, we further observed a novel 4 bp deletion/insertion polymorphism (ss4 bp, rs41352448) at 72,314 position of human arylsulfatase D pseudogene, defining a novel sub-lineage Q5 (in 5/15 individuals, i.e., 33.3 % of the observed Y-HG Q) with distributions independent of the social, cultural, linguistic and geographical affiliations in India. Conclusion The study adds another sublineage Q5 in the already existing arrangement of Y-HG Q in literature. It was quite interesting to observe an ancestral state Q* and a novel sub-branch Q5, not reported elsewhere, in Indian subcontinent, though in low frequency. A novel subgroup Q4 was identified recently which is also restricted to Indian subcontinent. The most plausible explanation for these observations could be an ancestral migration of individuals bearing ancestral lineage Q* to Indian subcontinent followed by an autochthonous differentiation to Q4 and Q5 sublineages later on. However, other explanations of, either the presence of both the sub haplogroups (Q4 and Q5) in ancestral migrants or recent migrations from central Asia, cannot be ruled out till the distribution and diversity of

  9. Regional mapping of loci from human chromosome 2q to sheep chromosome 2q

    SciTech Connect

    Ansari, H.A.; Pearce, P.D.; Maher, D.W.; Malcolm, A.A.; Wood, N.J.; Phua, S.H.; Broad, T.E. )

    1994-03-01

    The human chromosome 2q loci, fibronectin 1 (FN1), the [alpha]1 chain of type III collagen (COL3A1), and the [delta] subunit of the muscle acetylcholine receptor (CHRND) have been regionally assigned to sheep chromosome 2q by in situ hybridization. COL3A1 is pericentromeric (2q12-q21), while FN1 and CHRND are in the subterminal region at 2q41-q44 and 2q42-qter, respectively. The mapping of FN1 assigns the sheep synthenic group U11, which contains FN1, villin 1 (VIL1), isocitrate dehydrogenase 1 (IDH1), and [gamma] subunit of the muscle acetylcholine receptor (CHRNG), to sheep chromosome 2q. Inhibin-[alpha] (INHA) is also assigned to sheep chromosome 2q as FN1 and INHA compose sheep linkage group 3. These seven loci are members of a conserved chromosomal segment in human, mouse, and sheep. 23 refs., 2 figs., 1 tab.

  10. Antimicrobial therapies for Q fever

    PubMed Central

    Kersh, Gilbert J.

    2015-01-01

    Summary Q fever is caused by the bacterium Coxiella burnetii and has both acute and chronic forms. The acute disease is a febrile illness often with headache and myalgia that can be self-limiting whereas the chronic disease typically presents as endocarditis and can be life threatening. The normal therapy for the acute disease is a two week course of doxycycline, whereas chronic disease requires 18-24 months of doxycycline in combination with hydroxychloroquine. Alternative treatments are used for pregnant women, young children, and those who cannot tolerate doxycycline. Doxycycline resistance is rare but has been reported. Co-trimoxazole is a currently recommended alternative treatment, but quinolones, rifampin, and newer macrolides may also provide some benefit. PMID:24073941

  11. Integrated device architectures for electrochromic devices

    DOEpatents

    Frey, Jonathan Mack; Berland, Brian Spencer

    2015-04-21

    This disclosure describes systems and methods for creating monolithically integrated electrochromic devices which may be a flexible electrochromic device. Monolithic integration of thin film electrochromic devices may involve the electrical interconnection of multiple individual electrochromic devices through the creation of specific structures such as conductive pathway or insulating isolation trenches.

  12. Laser device

    DOEpatents

    Scott, Jill R.; Tremblay, Paul L.

    2004-11-23

    A laser device includes a target position, an optical component separated a distance J from the target position, and a laser energy source separated a distance H from the optical component, distance H being greater than distance J. A laser source manipulation mechanism exhibits a mechanical resolution of positioning the laser source. The mechanical resolution is less than a spatial resolution of laser energy at the target position as directed through the optical component. A vertical and a lateral index that intersect at an origin can be defined for the optical component. The manipulation mechanism can auto align laser aim through the origin during laser source motion. The laser source manipulation mechanism can include a mechanical index. The mechanical index can include a pivot point for laser source lateral motion and a reference point for laser source vertical motion. The target position can be located within an adverse environment including at least one of a high magnetic field, a vacuum system, a high pressure system, and a hazardous zone. The laser source and an electro-mechanical part of the manipulation mechanism can be located outside the adverse environment. The manipulation mechanism can include a Peaucellier linkage.

  13. Laser device

    DOEpatents

    Scott, Jill R.; Tremblay, Paul L.

    2007-07-10

    A laser device includes a target position, an optical component separated a distance J from the target position, and a laser energy source separated a distance H from the optical component, distance H being greater than distance J. A laser source manipulation mechanism exhibits a mechanical resolution of positioning the laser source. The mechanical resolution is less than a spatial resolution of laser energy at the target position as directed through the optical component. A vertical and a lateral index that intersect at an origin can be defined for the optical component. The manipulation mechanism can auto align laser aim through the origin during laser source motion. The laser source manipulation mechanism can include a mechanical index. The mechanical index can include a pivot point for laser source lateral motion and a reference point for laser source vertical motion. The target position can be located within an adverse environment including at least one of a high magnetic field, a vacuum system, a high pressure system, and a hazardous zone. The laser source and an electro-mechanical part of the manipulation mechanism can be located outside the adverse environment. The manipulation mechanism can include a Peaucellier linkage.

  14. Development and Use of Fluorescent Antibody and qPCR Protocols for the Electrostatic Spore Trap

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Fluorescent antibody (FA) and qPCR protocols were evaluated for the newly developed aerobiological sampler (Ionic Spore Trap), which depends upon electrostatic deposition of particulates onto a 25 mm aluminum disk (stub). This device was originally designed for assessment of captured particulates by...

  15. High Q Miniature Sapphire Acoustic Resonator

    NASA Technical Reports Server (NTRS)

    Wang, Rabi T.; Tjoelker, R. L.

    2010-01-01

    We have demonstrated high Q measurements in a room temperature Miniature Sapphire Acoustic Resonator (MSAR). Initial measurements of bulk acoustic modes in room temperature sapphire at 39 MHz have demonstrated a Q of 8.8 x 10(exp 6). The long term goal of this work is to integrate such a high Q resonator with small, low noise quartz oscillator electronics, providing a fractional frequency stability better than 1 x 10(exp -14) @ 1s.

  16. Electro-optic Q-switch

    NASA Technical Reports Server (NTRS)

    Zou, Yingyin (Inventor); Chen, Qiushui (Inventor); Zhang, Run (Inventor); Jiang, Hua (Inventor)

    2006-01-01

    An electro-optic Q-switch for generating sequence of laser pulses was disclosed. The Q-switch comprises a quadratic electro-optic material and is connected with an electronic unit generating a radio frequency wave with positive and negative pulses alternatively. The Q-switch is controlled by the radio frequency wave in such a way that laser pulse is generated when the radio frequency wave changes its polarity.

  17. Renormalons and 1/Q2 corrections

    NASA Astrophysics Data System (ADS)

    Akhoury, R.; Zakharov, V. I.

    1997-06-01

    We argue that the appearance of the Landau pole in the running coupling of QCD introduces 1/Q2 power corrections in current correlator functions. These terms are not accounted for by the standard operator product expansion and is the price to be paid for the lack of a unique definition of the running coupling at the 1/Q2 level. We review also possible phenomenological implications of the 1/Q2 terms in an alternative language of ultraviolet renormalon.

  18. Doubly active Q switching and mode locking of an all-fiber laser.

    PubMed

    Cuadrado-Laborde, Christian; Díez, Antonio; Cruz, Jose L; Andrés, Miguel V

    2009-09-15

    Simultaneous and independent active Q switching and active mode locking of an erbium-doped fiber laser is demonstrated using all-fiber modulation techniques. A magnetostrictive rod attached to the output fiber Bragg grating modulates the Q factor of the Fabry-Perot cavity, whereas active mode locking is achieved by amplitude modulation with a Bragg-grating-based acousto-optic device. Fully modulated Q-switched mode-locked trains of optical pulses were obtained for a wide range of pump powers and repetition rates. For a Q-switched repetition rate of 500 Hz and a pump power of 100 mW, the laser generates trains of 12-14 mode-locked pulses of about 1 ns each, within an envelope of 550 ns, an overall energy of 0.65 microJ, and a peak power higher than 250 W for the central pulses of the train. PMID:19756079

  19. Myelodysplastic Syndrome with concomitant t(5;21)(q15;q22) and del(5)(q13q33): case report and review of literature.

    PubMed

    Kasi Loknath Kumar, Anup; Weckbaugh, Brandon; Sirridge, Christopher; Woodroof, Janet; Persons, Diane; Kambhampati, Suman

    2016-01-01

    Chromosomal abnormalities lead to the development of hematologic malignancies such as Myelodysplastic Syndrome (MDS). Known chromosomal changes causing MDS include deletion of the long arm of chromosome 5, runt-related transcription factor 1 (RUNX1) also known as acute myeloid leukemia 1 protein (AML1), and very rarely fusion genes involving RUNX1 at t(5;21)(q15;q22). We present a case of a 71-year-old female with MDS, refractory anemia with excess blasts, type 1, with a combination of two cytogenetic abnormalities, specifically a concomitant translocation between chromosomes 5q15 and 21q22 and deletion of chromosome 5q13q33. Fluorescence in-situ hybridization (FISH) using a probe for RUNX1 (AML1), localized to 21q22, showed three FISH signals for RUNX1, consistent with rearrangement of RUNX1. Therapy was started with Lenalidomide leading to normal blood counts. Most significantly, repeat cytogenetics revealed normal karyotype and resolution of deletion on the long arm of chromosome 5 and a t(5;21). FISH negative for deletion 5q. The results altogether meet criteria for a complete cytogenetic remission (CR). We report a new case of t(5;21)(q15;q22) involving the RUNX1 gene and del(5)(q13q33) in a MDS patient, a combination of chromosomal abnormalities heretofore not reported in the literature. RUNX1 rearrangement is usually associated with an adverse prognosis in AML and MDS. Deletions of 5q are typically associated with poor prognosis in AML, however it is usually associated with a favorable prognosis in MDS. Our patient responded very well to Lenalidomide therapy with achievement of CR. Lenalidomide is approved for treatment of anemia in low and intermediate risk MDS with del (5q), however based on a search of literature it seems that RUNX1 mutations are also more prominent in patients who have responded to Lenalidomide therapy. MDS is a genomically unstable disease. Hence, it is conceivable that our patient started with a 5q minus syndrome and then acquired the

  20. A rare case of trisomy 11q23.3-11q25 and trisomy 22q11.1-22q11.21.

    PubMed

    Zou, P-S; Li, H-F; Chen, L-S; Ma, M; Chen, X-H; Xue, D; Cao, D-H

    2016-01-01

    Partial duplication of the long arm of chromosome 11 and the partial trisomy of 22q are uncommon karyotypic abnormalities. Here, we report the case of a 6-year-old girl who showed partial trisomy of 11q and 22q, as a result of a maternal balanced reciprocal translocation (11;22), and exhibited dysmorphic features, severe intellectual disability, brain malformations, and speech delay related to this unique chromosomal abnormality. Array comparative genomic hybridization (array CGH) revealed a gain in copy number on the long arm of chromosome 11, spanning at least 18.22 Mb. Additionally, there was a gain in copy number on the long arm of chromosome 22, spanning at least 3.46 Mb. FISH analysis using a chromosome 11 short arm telomere probe (11p14.2), a chromosome 11 long arm telomere probe (11q24.3), and a chromosome 22 long arm telomere probe (22q13.33) confirmed the origin of the marker chromosome. It has been confirmed by the State Key Laboratory of Medical Genetics of China that this is the first reported instance of the karyotype 47,XX, +der(22)t(11;22)(q23.3;q11.1)mat in the world. Our study reports an additional case that can be used to further characterize and delineate the clinical ramifications of partial trisomy of 11q and 22q. PMID:27173335

  1. Biosynthesis of coenzyme Q in eukaryotes.

    PubMed

    Kawamukai, Makoto

    2015-01-01

    Coenzyme Q (CoQ) is a component of the electron transport chain that participates in aerobic cellular respiration to produce ATP. In addition, CoQ acts as an electron acceptor in several enzymatic reactions involving oxidation-reduction. Biosynthesis of CoQ has been investigated mainly in Escherichia coli and Saccharomyces cerevisiae, and the findings have been extended to various higher organisms, including plants and humans. Analyses in yeast have contributed greatly to current understanding of human diseases related to CoQ biosynthesis. To date, human genetic disorders related to mutations in eight COQ biosynthetic genes have been reported. In addition, the crystal structures of a number of proteins involved in CoQ synthesis have been solved, including those of IspB, UbiA, UbiD, UbiX, UbiI, Alr8543 (Coq4 homolog), Coq5, ADCK3, and COQ9. Over the last decade, knowledge of CoQ biosynthesis has accumulated, and striking advances in related human genetic disorders and the crystal structure of proteins required for CoQ synthesis have been made. This review focuses on the biosynthesis of CoQ in eukaryotes, with some comparisons to the process in prokaryotes. PMID:26183239

  2. Q-balls in flat potentials

    SciTech Connect

    Copeland, Edmund J.; Tsumagari, Mitsuo I.

    2009-07-15

    We study the classical and absolute stability of Q-balls in scalar field theories with flat potentials arising in both gravity-mediated and gauge-mediated models. We show that the associated Q-matter formed in gravity-mediated potentials can be stable against decay into their own free particles as long as the coupling constant of the nonrenormalizable term is small, and that all of the possible three-dimensional Q-ball configurations are classically stable against linear fluctuations. Three-dimensional gauge-mediated Q-balls can be absolutely stable in the thin-wall limit, but are completely unstable in the thick-wall limit.

  3. C1q and systemic lupus erythematosus.

    PubMed

    Walport, M J; Davies, K A; Botto, M

    1998-08-01

    In this chapter we review the association between SLE and C1q. In the first part of the chapter we discuss the clinical associations of C1q deficiency, and tabulate the available information in the literature relating to C1q deficiency and autoimmune disease. Other clinical associations of C1q deficiency are then considered, and we mention briefly the association between other genetically determined complement deficiencies and lupus. In the review we explore the relationship between C1q consumption and lupus and we discuss the occurrence of low molecular weight (7S) C1q in lupus, which raises the possibility that increased C1q turnover in the disease may result in unbalanced chain synthesis of the molecule. Anti-C1q antibodies are also strongly associated with severe SLE affecting the kidney, and with hypocomplementaemic urticarial vasculitis, and these associations are also examined. We address the question of how C1q deficiency may cause SLE, discussing the possibility that this may be due to abnormalities of immune complex processing, which have been well characterised in a umber of different human models. There is clear evidence that immune complex processing is abnormal in patients with hypocomplementaemia, and this is compatible with the hypothesis that ineffective immune complex clearance could cause tissue injury, and this may in turn stimulate an autoantibody response. We have also considered the possibility that C1q-C1q receptor interactions are critical in the regulation of apoptosis, and we explore the hypothesis that dysregulation of apoptosis could explain important features in the development of autoimmune disease associated with C1q deficiency. An abnormally high rate of apoptosis, or defective clearance of apoptotic cells, could promote the accumulation of abnormal cellular products that might drive an autoimmune response. Anti-C1q antibodies have been described in a number of murine models of lupus, and these are also briefly discussed. We focus

  4. Compact Q-balls and Q-shells in a scalar electrodynamics

    SciTech Connect

    Arodz, H.; Lis, J.

    2009-02-15

    We investigate spherically symmetric nontopological solitons in electrodynamics with a scalar field self-interaction U{approx}|{psi}| taken from the complex signum-Gordon model. We find Q-balls for small absolute values of the total electric charge Q, and Q-shells when |Q| is large enough. In both cases the charge density exactly vanishes outside certain compact regions in the three-dimensional space. The dependence of the total energy E of small Q-balls on the total electric charge has the form E{approx}|Q|{sup 5/6}, while in the case of very large Q-shells, E{approx}|Q|{sup 7/6}.

  5. /q-exponential, Weibull, and /q-Weibull distributions: an empirical analysis

    NASA Astrophysics Data System (ADS)

    Picoli, S.; Mendes, R. S.; Malacarne, L. C.

    2003-06-01

    In a comparative study, the q-exponential and Weibull distributions are employed to investigate frequency distributions of basketball baskets, cyclone victims, brand-name drugs by retail sales, and highway length. In order to analyze the intermediate cases, a distribution, the q-Weibull one, which interpolates the q-exponential and Weibull ones, is introduced. It is verified that the basketball baskets distribution is well described by a q-exponential, whereas the cyclone victims and brand-name drugs by retail sales ones are better adjusted by a Weibull distribution. On the other hand, for highway length the q-exponential and Weibull distributions do not give satisfactory adjustment, being necessary to employ the q-Weibull distribution. Furthermore, the introduction of this interpolating distribution gives an illumination from the point of view of the stretched exponential against inverse power law ( q-exponential with q>1) controversy.

  6. P/Q-type calcium channel modulators

    PubMed Central

    Nimmrich, V; Gross, G

    2012-01-01

    P/Q-type calcium channels are high-voltage-gated calcium channels contributing to vesicle release at synaptic terminals. A number of neurological diseases have been attributed to malfunctioning of P/Q channels, including ataxia, migraine and Alzheimer's disease. To date, only two specific P/Q-type blockers are known: both are peptides deriving from the spider venom of Agelenopsis aperta, ω-agatoxins. Other peptidic calcium channel blockers with activity at P/Q channels are available, albeit with less selectivity. A number of low molecular weight compounds modulate P/Q-type currents with different characteristics, and some exhibit a peculiar bidirectional pattern of modulation. Interestingly, there are a number of therapeutics in clinical use, which also show P/Q channel activity. Because selectivity as well as the exact mode of action is different between all P/Q-type channel modulators, the interpretation of clinical and experimental data is complicated and needs a comprehensive understanding of their target profile. The situation is further complicated by the fact that information on potency varies vastly in the literature, which may be the result of different experimental systems, conditions or the splice variants of the P/Q channel. This review attempts to provide a comprehensive overview of the compounds available that affect the P/Q-type channel and should help with the interpretation of results of in vitro experiments and animal models. It also aims to explain some clinical observations by implementing current knowledge about P/Q channel modulation of therapeutically used non-selective drugs. Chances and challenges of the development of P/Q channel-selective molecules are discussed. PMID:22670568

  7. Study of structural and optical properties of ZnAlQ5 (zinc aluminum quinolate) organic phosphor for OLED applications

    NASA Astrophysics Data System (ADS)

    Nagpure, I. M.; Painuly, Deepshikha; Rabanal, Maria Eugenia

    2016-05-01

    The various composition of ZnAlQ5 such as Zn1.5A10.5Q5, Zn1Al1Q5, Zn0.5Al1.5Q5 organic phosphors were prepared via simple cost effective co-precipitation method. The FTIR, SEM, photoluminescence analysis of the prepared phosphors were reported. ZnQ2 and AlQ3 were also prepared by similar method and their properties were compared with different composition of ZnAlQ5. The structural elucidation in the form of stretching frequencies of chemical bonds of the prepared phosphor was carried out using Fourier Transform Infrared Spectroscopy (FTIR). The stretching frequency analysis confirms the formation of prepared phosphor materials. The SEM analysis shows the surface morphological behavior of prepared phosphor materials. Greenish photoluminescence were observed at 505 to 510 nm for the different composition of ZnAlQ5,in which Zn1.5Al0.5Q5 shows maximum luminescence intensity at 505 nm. PL emission of ZnQ2 was observed at 515 nm, while for AlQ3 at 520 nm. The blue shift of 10 nm was observed in Zn1.5A10.5Q5 due to modification of energy level due to presence of Zn2+ and Al3+. The enhancement in PL intensity was observed in Zn1.5A10.5Q5 compared to the other composition due to transfer of energy between Zn2+ and quinolate complex. Optical properties of the prepared materials were evaluated for possible applications in organic light emitting devices (OLED).

  8. Electromagnetic pulse-induced current measurement device

    NASA Astrophysics Data System (ADS)

    Gandhi, Om P.; Chen, Jin Y.

    1991-08-01

    To develop safety guidelines for exposure to high fields associated with an electromagnetic pulse (EMP), it is necessary to devise techniques that would measure the peak current induced in the human body. The main focus of this project was to design, fabricate, and test a portable, self-contained stand-on device that would measure and hold the peak current and the integrated change Q. The design specifications of the EMP-Induced Current Measurement Device are as follows: rise time of the current pulse, 5 ns; peak current, 20-600 A; charge Q, 0-20 microcoulombs. The device uses a stand-on parallel-plate bilayer sensor and fast high-frequency circuit that are well-shielded against spurious responses to high incident fields. Since the polarity of the incident peak electric field of the EMP may be either positive or negative, the induced peak current can also be positive or negative. Therefore, the device is designed to respond to either of these polarities and measure and hold both the peak current and the integrated charge which are simultaneously displayed on two separate 3-1/2 digit displays. The prototype device has been preliminarily tested with the EMP's generated at the Air Force Weapons Laboratory (ALECS facility) at Kirtland AFB, New Mexico.

  9. Interstitial deletion of 6q21-q23 associated with split hand

    SciTech Connect

    Tsukahara, Masato; Yoneda, Junko; Azuma, Reiko

    1997-03-31

    We report on a 7-month-old boy with interstitial deletion of 6q21-q23 and split-hand defect. He died at 7 months. This is the fifth patient with distal limb anomaly associated with a rearrangement of 6q21 region, and supports previous suggestions that there may be candidate gene(s) for distal limb development in the 6q21 region. 10 refs., 3 figs., 1 tab.

  10. Prader-Willi, Angelman, and 15q11-q13 Duplication Syndromes.

    PubMed

    Kalsner, Louisa; Chamberlain, Stormy J

    2015-06-01

    Three distinct neurodevelopmental disorders arise primarily from deletions or duplications that occur at the 15q11-q13 locus: Prader-Willi syndrome, Angelman syndrome, and 15q11-q13 duplication syndrome. Each of these disorders results from the loss of function or overexpression of at least 1 imprinted gene. This article discusses the clinical background, genetic cause, diagnostic strategy, and management of each of these 3 disorders. PMID:26022164

  11. De novo interstitial tandem duplication of chromosome 4(q21-q28)

    SciTech Connect

    Navarro, E.G.; Ramon, F.J.H.; Jimenez, R.D.

    1996-03-29

    We describe a girl with a previously unreported de novo duplication of chromosome 4q involving segment q21-q28. Clinical manifestations included growth and psychomotor retardation, facial asymmetry, hypotelorism, epicanthic folds, mongoloid slant of palpebral fissures, apparently low-set auricles, high nasal bridge, long philtrum, small mouth, short neck, low-set thumbs, and bilateral club foot. This phenotype is compared with that of previously reported cases of duplication 4q. 12 refs., 3 figs., 1 tab.

  12. 40 CFR Table 1 to Subpart Q of... - General Provisions Applicability to Subpart Q

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Reference Applies to Subpart Q Comment 63.1 Yes 63.2 Yes 63.3 No 63.4 Yes 63.5 No 63.6 (a), (b), (c), and (j... § 63.405(a) and § 63.405(b), respectively, of subpart Q; other provisions of subpart A are not relevant... Subpart Q 1 Table 1 to Subpart Q of Part 63 Protection of Environment ENVIRONMENTAL PROTECTION...

  13. What's Your Stroke I.Q.?

    MedlinePlus

    What's Your Stroke I.Q.? Often, it is believed that stroke is a disease of old age. You may be surprised to learn that stroke ... to help prevent it. Test your stroke I.Q. by answering these six questions. By knowing the ...

  14. Understanding Insight in the Context of Q

    ERIC Educational Resources Information Center

    Coghlan, David

    2012-01-01

    In Revans' learning formula, L = P + Q, Q represents "questioning insight", by which Revans means that insight comes out of the process of questioning programmed knowledge (P) in the light of experience. We typically focus on the content of an insight rather than on the act of insight. Drawing primarily on the work of Bernard Lonergan this paper…

  15. Q Fever Chronic Osteomyelitis in Two Children.

    PubMed

    Costa, Beatriz; Morais, Andreia; Santos, Ana Sofia; Tavares, Delfin; Seves, Graça; Gouveia, Catarina

    2015-11-01

    We report 2 cases of chronic Q fever osteomyelitis in 10- and 5-year-old girls who presented with distal right femoral and left parasternal granulomatous osteomyelitis, respectively. Both were treated with ciprofloxacin and rifampin with good response. Q fever osteomyelitis is a challenging diagnosis in children, and the choice of antimicrobial treatment is difficult because of limited available data. PMID:26226441

  16. Information entrophy via Glauber's Q-representation

    NASA Technical Reports Server (NTRS)

    Keitel, C. H.; Wodkiewicz, K.

    1993-01-01

    We present a convenient way to evaluate the information entropy of a quantum mechanical state via the Glauber Q-representation. As an example we discuss the information entropy of a thermally relaxing squeezed state in terms of its Q-representation and show the validity of the corresponding entropic uncertainty- and Araki-Lieb inequalities.

  17. Coenzyme Q10 Deficiencies in Neuromuscular Diseases

    PubMed Central

    Salviati, Leonardo; Jackson, Sandra; Hirano, Michio; Navas, Plácido

    2011-01-01

    Coenzyme Q (CoQ) is an essential component of the respiratory chain but also participates in other mitochondrial functions such as regulation of the transition pore and uncoupling proteins. Furthermore, this compound is a specific substrate for enzymes of the fatty acids β–oxidation pathway and pyrimidine nucleotide biosynthesis. Furthermore, CoQ is an antioxidant that acts in all cellular membranes and lipoproteins. A complex of at least ten nuclear (COQ) genes encoded proteins synthesizes CoQ but its regulation is unknown. Since 1989, a growing number of patients with multisystemic mitochondrial disorders and neuromuscular disorders showing deficiencies of CoQ have been identified. CoQ deficiency caused by muta-tion(s) in any of the COQ genes is designated primary deficiency. Other patients have displayed other genetic defects independent on the CoQ biosynthesis pathway, and are considered to have secondary deficiencies. This review updates the clinical and molecular aspects of both types of CoQ deficiencies and proposes new approaches to understanding their molecular bases. PMID:20225022

  18. Another patient with 12q13 microduplication.

    PubMed

    Bertoli, M; Alesi, V; Gullotta, F; Zampatti, S; Abate, M R; Palmieri, C; Novelli, A; Frontali, M; Nardone, A M

    2013-08-01

    Interstitial duplication of the long arm of chromosome 12 is a rare cytogenetic condition. While several reports describe distal 12q duplication, only one case report of homogeneous, non-mosaic interstitial 12q13 duplication has been documented to date. The authors of that observation proposed that the associated phenotype represented a phenocopy of Wolf-Hirschhorn syndrome [Dallapiccola et al., 2009]. Only a few other recorded patients with deletion 12q13 → 12q21 involved mosaicism. We describe a new patient with homogeneous 12q13 duplication in a 6-year-old girl who, in early infancy, presented with dysmorphic features suggesting Wolf-Hirschhorn syndrome. What is potentially significant about this patient is that her facial phenotype evolved with age, suggesting a different gestalt in older patients. PMID:23824684

  19. Q Model for the Pacific Northwest

    SciTech Connect

    Hearn, Thomas; Phillips, William S.

    2012-07-24

    USArray seismic data can be used to generate high resolution attenuation (1/Q) models using regional wave amplitudes. Our Q models have been produced for purposes of explosion monitoring (discrimination and yield estimation), for which we focus on small signals at local to regional distances (to 2000 km). We present Q models for regional Lg, which is sensitive to crustal properties averaged over depth. The frequency range of the study is 0.5-16 Hz. Details of Q models may have limited effect over the short distances of interest to hazard work; however, maps may be useful for regionalizing high versus low Q areas. This study has been submitted to a PAGEOPH special issue on monitoring seismology.

  20. F-term inflation Q-balls

    SciTech Connect

    McDonald, John

    2006-02-15

    A general analysis of Q-ball solutions of the supersymmetric F-term hybrid inflation field equations is given. The solutions consist of a complex inflaton field and a real symmetry-breaking field, with a conserved global charge associated with the inflaton. It is shown that the Q-ball solutions for any value of the superpotential coupling, {kappa}, may be obtained from those with {kappa}=1 by rescaling the space coordinates. The complete range of Q-ball solutions for the case {kappa}=1 is given, from which all possible F-term inflation Q-balls can be obtained. The possible role of F-term inflation Q-balls in cosmology is discussed.

  1. Seismic Q of the lunar upper mantle

    NASA Astrophysics Data System (ADS)

    Nakamura, Y.; Koyama, J.

    1982-06-01

    Shallow moonquake data are used to determine the frequency dependence of Q values for both compressional and shear waves in the upper mantle of the moon at frequencies between 3 and 8 Hz. The seismic P wave Q is estimated to be at least 4000 and is nearly independent of frequency or decreases slightly with increasing frequency, while the S wave Q increases from at least 4000 at 3 Hz to at least 7000 at 8 Hz. The rate of increase of Q(S) is approximately proportional to the 0.7 + or - 0.1 power of the frequency above 5 Hz. With the absence of other dissipation mechanisms, compressional heat loss may be a dominant factor in the lunar interior. Uncertainty remains, however, in the absolute values of Q's owing to the largely unknown detailed structure of the lunar upper mantle.

  2. Chronic Q Fever in the United States

    PubMed Central

    Karakousis, Petros C.; Trucksis, Michele; Dumler, J. Stephen

    2006-01-01

    Infections due to Coxiella burnetii, the causative agent of Q fever, are uncommon in the United States. Cases of chronic Q fever are extremely rare and most often manifest as culture-negative endocarditis in patients with underlying valvular heart disease. We describe a 31-year-old farmer from West Virginia with a history of congenital heart disease and recurrent fevers for 14 months who was diagnosed with Q fever endocarditis based on an extremely high antibody titer against Coxiella burnetii phase I antigen. Despite treatment with doxycycline, he continued to have markedly elevated Coxiella burnetii phase I antibody titers for 10 years after the initial diagnosis. To our knowledge, this case represents the longest follow-up period for a patient with chronic Q fever in the United States. We review all cases of chronic Q fever reported in the United States and discuss important issues pertaining to epidemiology, diagnosis, and management of this disease. PMID:16757641

  3. Seismic Q of the lunar upper mantle

    NASA Technical Reports Server (NTRS)

    Nakamura, Y.; Koyama, J.

    1982-01-01

    Shallow moonquake data are used to determine the frequency dependence of Q values for both compressional and shear waves in the upper mantle of the moon at frequencies between 3 and 8 Hz. The seismic P wave Q is estimated to be at least 4000 and is nearly independent of frequency or decreases slightly with increasing frequency, while the S wave Q increases from at least 4000 at 3 Hz to at least 7000 at 8 Hz. The rate of increase of Q(S) is approximately proportional to the 0.7 + or - 0.1 power of the frequency above 5 Hz. With the absence of other dissipation mechanisms, compressional heat loss may be a dominant factor in the lunar interior. Uncertainty remains, however, in the absolute values of Q's owing to the largely unknown detailed structure of the lunar upper mantle.

  4. Olanzapine induced Q-Tc shortening

    PubMed Central

    Fallah Jahromi, Parisa

    2014-01-01

    Introduction Prolongation of Q-Tc interval is commonly accepted as a surrogate marker for the ability of a drug to cause torsade de pointes. In the present study, safety of olanzapine versus risperidone was compared among a group of patients with schizophrenia to see the frequency of the electrocardiographic alterations induced by those atypical antipsychotics. Method Two hundred and sixty-eight female inpatients with schizophrenia entered in one of the two parallel groups to participate in an open study for random assignment to olanzapine (n = 148) or risperidone (n = 120). Standard 12-lead surface electrocardiogram (ECG) was taken from each patient at baseline, before initiation of treatment, and then at the end of management, just before discharge. The parameters that were assessed included heart rate (HR), P-R interval, QRS interval, Q-T interval (corrected = Q-Tc), ventricular activation time (VAT), ST segment, T wave, axis of QRS, and finally, interventricular conduction process. Results A total of 37.83% of cases in the olanzapine group and 30% in the risperidone group showed some Q-Tc changes; 13.51% and 24.32% of the patients in the olanzapine group showed prolongation and shortening of the Q-Tc, respectively, while changes in the risperidone group were restricted to only prolongation of Q-Tc. Comparison of means showed a significant increment in Q-Tc by risperidone (p = 0.02). Also, comparison of proportions in the olanzapine group showed significantly more cases with shortening of Q-Tc versus its prolongation (p = 0.01). No significant alterations with respect to other variables were evident. Conclusion Olanzapine and risperidone had comparable potentiality for induction of Q-Tc changes, while production of further miscellaneous alterations in ECG was more observable in the olanzapine group compared with the risperidone group. Also shortening of Q-Tc was specific to olanzapine. PMID:25489475

  5. Coenzyme Q biosynthesis in health and disease.

    PubMed

    Acosta, Manuel Jesús; Vazquez Fonseca, Luis; Desbats, Maria Andrea; Cerqua, Cristina; Zordan, Roberta; Trevisson, Eva; Salviati, Leonardo

    2016-08-01

    Coenzyme Q (CoQ, or ubiquinone) is a remarkable lipid that plays an essential role in mitochondria as an electron shuttle between complexes I and II of the respiratory chain, and complex III. It is also a cofactor of other dehydrogenases, a modulator of the permeability transition pore and an essential antioxidant. CoQ is synthesized in mitochondria by a set of at least 12 proteins that form a multiprotein complex. The exact composition of this complex is still unclear. Most of the genes involved in CoQ biosynthesis (COQ genes) have been studied in yeast and have mammalian orthologues. Some of them encode enzymes involved in the modification of the quinone ring of CoQ, but for others the precise function is unknown. Two genes appear to have a regulatory role: COQ8 (and its human counterparts ADCK3 and ADCK4) encodes a putative kinase, while PTC7 encodes a phosphatase required for the activation of Coq7. Mutations in human COQ genes cause primary CoQ(10) deficiency, a clinically heterogeneous mitochondrial disorder with onset from birth to the seventh decade, and with clinical manifestation ranging from fatal multisystem disorders, to isolated encephalopathy or nephropathy. The pathogenesis of CoQ(10) deficiency involves deficient ATP production and excessive ROS formation, but possibly other aspects of CoQ(10) function are implicated. CoQ(10) deficiency is unique among mitochondrial disorders since an effective treatment is available. Many patients respond to oral CoQ(10) supplementation. Nevertheless, treatment is still problematic because of the low bioavailability of the compound, and novel pharmacological approaches are currently being investigated. This article is part of a Special Issue entitled 'EBEC 2016: 19th European Bioenergetics Conference, Riva del Garda, Italy, July 2-6, 2016', edited by Prof. Paolo Bernardi. PMID:27060254

  6. Connector device for building integrated photovoltaic device

    DOEpatents

    Keenihan, James R.; Langmaid, Joseph A.; Eurich, Gerald K.; Lesniak, Michael J.; Mazor, Michael H.; Cleereman, Robert J.; Gaston, Ryan S.

    2014-06-03

    The present invention is premised upon a connector device and method that can more easily electrically connect a plurality of PV devices or photovoltaic system components and/or locate these devices/components upon a building structure. It also may optionally provide some additional sub-components (e.g. at least one bypass diode and/or an indicator means) and may enhance the serviceability of the device.

  7. Connector device for building integrated photovoltaic device

    DOEpatents

    Keenihan, James R.; Langmaid, Joe A.; Eurich, Gerald K.; Lesniak, Michael J.; Mazor, Michael H.; Cleerman, Robert J.; Gaston, Ryan S.

    2015-11-10

    The present invention is premised upon a connector device and method that can more easily electrically connect a plurality of PV devices or photovoltaic system components and/or locate these devices/components upon a building structure. It also may optionally provide some additional sub-components (e.g. at least one bypass diode and/or an indicator means) and may enhance the serviceability of the device.

  8. q-Painlevé VI Equation Arising from q-UC Hierarchy

    NASA Astrophysics Data System (ADS)

    Tsuda, Teruhisa; Masuda, Tetsu

    2006-03-01

    We study the q-difference analogue of the sixth Painlevé equation ( q- P VI) by means of tau functions associated with the affine Weyl group of type D 5. We prove that a solution of q- P VI coincides with a self-similar solution of the q-UC hierarchy. As a consequence, we obtain in particular algebraic solutions of q- P VI in terms of the universal character which is a generalization of the Schur polynomial attached to a pair of partitions.

  9. De novo interstitial deletion q16.2q21 on chromosome 6

    SciTech Connect

    Villa, A.; Urioste, M.; Luisa, M.

    1995-01-30

    A de novo interstitial deletion of 6q16.2q21 was observed in a 23-month-old boy with mental and psychomotor delay, obese appearance, minor craniofacial anomalies, and brain anomalies. We compare clinical manifestations of this patient with those observed in previously reported cases with similar 6q interstitial deletions. It is interesting to note the clinical similarities between some patients with interstitial deletions of 6q16 or q21 bands and patients with Prader-Willi syndrome (PWS) and it may help to keep in mind cytogenetic studies of patients with some PWS findings. 24 refs., 3 figs., 2 tabs.

  10. CMOS compatible high-Q photonic crystal nanocavity fabricated with photolithography on silicon photonic platform

    PubMed Central

    Ooka, Yuta; Tetsumoto, Tomohiro; Fushimi, Akihiro; Yoshiki, Wataru; Tanabe, Takasumi

    2015-01-01

    Progress on the fabrication of ultrahigh-Q photonic-crystal nanocavities (PhC-NCs) has revealed the prospect for new applications including silicon Raman lasers that require a strong confinement of light. Among various PhC-NCs, the highest Q has been recorded with silicon. On the other hand, microcavity is one of the basic building blocks in silicon photonics. However, the fusion between PhC-NCs and silicon photonics has yet to be exploited, since PhC-NCs are usually fabricated with electron-beam lithography and require an air-bridge structure. Here we show that a 2D-PhC-NC fabricated with deep-UV photolithography on a silica-clad silicon-on-insulator (SOI) structure will exhibit a high-Q of 2.2 × 105 with a mode-volume of ~1.7(λ/n)3. This is the highest Q demonstrated with photolithography. We also show that this device exhibits an efficient thermal diffusion and enables high-speed switching. The demonstration of the photolithographic fabrication of high-Q silica-clad PhC-NCs will open possibility for mass-manufacturing and boost the fusion between silicon photonics and CMOS devices. PMID:26086849

  11. CMOS compatible high-Q photonic crystal nanocavity fabricated with photolithography on silicon photonic platform.

    PubMed

    Ooka, Yuta; Tetsumoto, Tomohiro; Fushimi, Akihiro; Yoshiki, Wataru; Tanabe, Takasumi

    2015-01-01

    Progress on the fabrication of ultrahigh-Q photonic-crystal nanocavities (PhC-NCs) has revealed the prospect for new applications including silicon Raman lasers that require a strong confinement of light. Among various PhC-NCs, the highest Q has been recorded with silicon. On the other hand, microcavity is one of the basic building blocks in silicon photonics. However, the fusion between PhC-NCs and silicon photonics has yet to be exploited, since PhC-NCs are usually fabricated with electron-beam lithography and require an air-bridge structure. Here we show that a 2D-PhC-NC fabricated with deep-UV photolithography on a silica-clad silicon-on-insulator (SOI) structure will exhibit a high-Q of 2.2 × 10(5) with a mode-volume of ~ 1.7(λ/n)(3). This is the highest Q demonstrated with photolithography. We also show that this device exhibits an efficient thermal diffusion and enables high-speed switching. The demonstration of the photolithographic fabrication of high-Q silica-clad PhC-NCs will open possibility for mass-manufacturing and boost the fusion between silicon photonics and CMOS devices. PMID:26086849

  12. Observation of the fundamental Nyquist noise limit in an ultra-high Q-factor cryogenic bulk acoustic wave cavity

    SciTech Connect

    Goryachev, Maxim Ivanov, Eugene N.; Tobar, Michael E.; Kann, Frank van; Galliou, Serge

    2014-10-13

    Thermal Nyquist noise fluctuations of high-Q bulk acoustic wave cavities have been observed at cryogenic temperatures with a DC superconducting quantum interference device amplifier. High Q modes with bandwidths of few tens of milliHz produce thermal fluctuations with a signal-to-noise ratio of up to 23 dB. The estimated effective temperature from the Nyquist noise is in good agreement with the physical temperature of the device, confirming the validity of the equivalent circuit model and the non-existence of any excess resonator self-noise. The measurements also confirm that the quality factor remains extremely high (Q > 10{sup 8} at low order overtones) for very weak (thermal) system motion at low temperatures, when compared to values measured with relatively strong external excitation. This result represents an enabling step towards operating such a high-Q acoustic device at the standard quantum limit.

  13. Coupling, Q-Factor, and Integration Aspects of Microsphere Applications

    NASA Technical Reports Server (NTRS)

    Ilchenko, V. S.; Yao, X. S.; Maleki, L.

    2000-01-01

    With suggested applications varying from microlaser and cavity QED through optical locking of diode lasers to modulators and sensors, high-Q silica microspheres with whispering-gallery (WG) modes so far remain the subject of tabletop feasibility demonstrations. Despite the uniquely high quality-factor and submillimeter dimensions suitable for tight packaging, this novel type of high-finesse cavity still has to be adapted to fiber- and integrated-optic hardware. In the visible and near infrared-band experiments (633-850nm) measuring the ringdown time tau of free oscillations, Q = (0.6 to 0.8 ) x 10(exp 10) has been obtained in silica spheres of diameter -800 microns (corresponding tau = 3 to 4 microseconds). It was proved that under normal laboratory conditions, quality-factor is subject to deterioration within several-minute scale down to (2 ... 3 ) x 10(exp 9). The responsible mechanism was identified as adsorption of a monolayer of atmospheric water, so that preservation of the ultimate Q requires manipulation in dry environment, or fast packaging into sealed devices. Larger Q can be expected closer to minimum of attenuation in fused silica alpha = 0.2 dB/km; Q greater than or equal to 1 x 10(exp 11) at lambda=1.55 microns, with corresponding energy storage time tau approx. 0.1ms. Experiments are currently underway to determine whether this high Q can be realized experimentally. The evident difficulty is that OH-related optical absorption has its peaks located near the reported minimum of attenuation in silica. We can also mention here that some of proposed fiber materials, yet not ready for fiber drawing, have been predicted to have smaller attenuation than fused silica and may be suitable for microsphere fabrication (sodium-magnesium silicate glass, alpha = 0.06dB/km). WG modes possess very small radiative loss (it does not prevent Q-10(exp 20) and more) and therefore are electromagnetically isolated and cannot be excited by free-space beams. If no modification

  14. Infrared criminalistic devices

    NASA Astrophysics Data System (ADS)

    Gibin, Igor S.; Savkov, E. V.; Popov, Pavel G.

    1996-12-01

    We are presenting the devices of near-IR spectral range in this report. The devices may be used in criminalistics, in bank business, in restoration works, etc. the action principle of these devices is describing briefly.

  15. Medical Device Safety

    MedlinePlus

    A medical device is any product used to diagnose, cure, or treat a condition, or to prevent disease. They range ... may need one in a hospital. To use medical devices safely Know how your device works. Keep instructions ...

  16. Medical Device Safety

    MedlinePlus

    A medical device is any product used to diagnose, cure, or treat a condition, or to prevent disease. They ... may need one in a hospital. To use medical devices safely Know how your device works. Keep ...

  17. Discovery and Characterization of HemQ

    PubMed Central

    Dailey, Tamara A.; Boynton, Tye O.; Albetel, Angela-Nadia; Gerdes, Svetlana; Johnson, Michael K.; Dailey, Harry A.

    2010-01-01

    Here we identify a previously undescribed protein, HemQ, that is required for heme synthesis in Gram-positive bacteria. We have characterized HemQ from Bacillus subtilis and a number of Actinobacteria. HemQ is a multimeric heme-binding protein. Spectroscopic studies indicate that this heme is high spin ferric iron and is ligated by a conserved histidine with the sixth coordination site available for binding a small molecule. The presence of HemQ along with the terminal two pathway enzymes, protoporphyrinogen oxidase (HemY) and ferrochelatase, is required to synthesize heme in vivo and in vitro. Although the exact role played by HemQ remains to be characterized, to be fully functional in vitro it requires the presence of a bound heme. HemQ possesses minimal peroxidase activity, but as a catalase it has a turnover of over 104 min−1. We propose that this activity may be required to eliminate hydrogen peroxide that is generated by each turnover of HemY. Given the essential nature of heme synthesis and the restricted distribution of HemQ, this protein is a potential antimicrobial target for pathogens such as Mycobacterium tuberculosis. PMID:20543190

  18. Radiation Q of dipole-generated fields

    NASA Astrophysics Data System (ADS)

    Grimes, Dale M.; Grimes, Craig A.

    1999-03-01

    The radiation Q of several dipole fields in free space are determined using the time-dependent Poynting theorem. Earlier works on this subject, recently summarized by McLean [1996], are based upon the complex Poynting theorem. It was previously shown [Grimes and Grimes, 1997] that the full complex Poynting theorem is correct only for single-mode radiation fields. The time-dependent theorem shows that three numbers are necessary to completely specify time-varying power, and complex numbers supply but two; the third piece of information, a phase, is discarded when complex notation is formed. Omissions inherent in the complex Poynting theorem affect the calculated value of standing energy about an antenna and hence the calculated value of Q. To avoid such omissions, we develop a method of determining Q based upon the time-dependent Poynting theorem that builds upon and extends our earlier work [Grimes and Grimes, 1997]. The purposes of this paper are to (1) provide a time domain basis for calculating Q in mixed modal radiation fields, (2) determine the Q of electric and magnetic dipoles, alone and in combination, and (3) demonstrate how source structure and relative phasing affect the physics of several combinations of electric and magnetic dipole radiation fields. The primary conclusion of this work is that the minimum possible Q of a radiation source established by Chu [1948] does not extend to properly mixed and phased multimodal radiation fields. A radiation source is presented for which, by our analysis, the radiation Q is zero.

  19. Chromosome alterations in breast carcinomas: frequent involvement of DNA losses including chromosomes 4q and 21q.

    PubMed Central

    Schwendel, A.; Richard, F.; Langreck, H.; Kaufmann, O.; Lage, H.; Winzer, K. J.; Petersen, I.; Dietel, M.

    1998-01-01

    Comparative genomic hybridization was applied to map DNA gains and losses in 39 invasive ductal breast carcinomas. Frequent abnormalities included gains on chromosomal regions 1q, 8q, 11q12-13, 16p, 19, 20q and X as well as frequent losses on 1p, 5q, 6q, 9p, 11q, 13q and 16q. Furthermore, frequent losses on 4q (20 cases) and 21q (14 cases) were found for the first time in this tumour type. High copy number amplifications were observed at 8q12-24, 11q11-13 and 20q13-ter. Highly differentiated tumours were associated with gains on 1q and 11q12-13 along with losses on 1p21-22, 4q, 13q, 11q21-ter. Undifferentiated breast carcinomas were characterized by additional DNA imbalances, i.e. deletions of 5q13-23, all of chromosome 9, the centromeric part of chromosome 13 including band 13q14 and the overrepresentation of chromosome X. We speculate that these changes are associated with tumour progression of invasive ductal breast cancer. Images Figure 2 Figure 3 PMID:9743305

  20. Gravitational waves from Q-ball formation

    SciTech Connect

    Chiba, Takeshi; Kamada, Kohei; Yamaguchi, Masahide

    2010-04-15

    We study the detectability of the gravitational waves (GWs) from the Q-ball formation associated with the Affleck-Dine (AD) mechanism, taking into account both the dilution effects due to Q-ball domination and to finite temperature. The AD mechanism predicts the formation of nontopological solitons, Q-balls, from which GWs are generated. Q-balls with large conserved charge Q can produce a large amount of GWs. On the other hand, the decay rate of such Q-balls is so small that they may dominate the energy density of the Universe, which implies that GWs are significantly diluted and that their frequencies are redshifted during the Q-ball dominated era. Thus, the detectability of the GWs associated with the formation of Q-balls is determined by these two competing effects. We find that there is a finite but small parameter region where such GWs may be detected by future detectors such as DECIGO or BBO, only in the case when the thermal logarithmic potential dominates the potential of the AD field. Otherwise GWs from Q-balls would not be detectable even by these futuristic detectors: {Omega}{sub GW}{sup 0}<10{sup -21}. Unfortunately, for such parameter region the present baryon asymmetry of the Universe can hardly be explained unless one fine-tunes A-terms in the potential. However the detection of such a GW background may give us an information about the early Universe, for example, it may suggest that the flat directions with B-L=0 are favored.

  1. Adult case of partial trisomy 9q

    PubMed Central

    2010-01-01

    Background Complete and partial trisomy 9 is the fourth most common chromosomal disorder. It is also associated with various congenital characteristics affecting the cranio-facial, skeletal, central nervous, gastrointestinal, cardiac and renal systems. Very few cases have been reported in adults. Partial trisomy 9q is also associated with short stature, poor growth and growth hormone deficiency. This is the first reported case of an extensive endocrinology investigation of short stature in trisomy 9q and the outcome of growth hormone treatment. Case Presentation The case involves a 23-year-old female of pure partial trisomy 9q. The case involves a 23-year old female with pure partial trisomy 9q involving a duplication of 9q22.1 to q32, de novo, confirmed by genetic studies using fluorescene in situ hybridization (FISH) method. The diagnosis was at 6 years of age. She did not demonstrate all the congenital morphologies identified with trisomy 9q disorders especially in relation to multi-organ morphologies. There is also a degree of associated intellectual impairment. At prepuberty, she was referred for poor growth and was diagnosed with partial growth hormone deficiency. She responded very well to treatment with growth hormone and is currently living an independent life with some support. Conclusions Trisomy 9q is associated with short stature and failure to thrive. Growth hormone deficiency should be identified in cases of trisomy 9q and treatment offered. This is the first reported case of response to growth hormone replacement in partial trisomy 9. PMID:20158889

  2. Dispersion engineering of high-Q silicon microresonators via thermal oxidation

    SciTech Connect

    Jiang, Wei C.; Zhang, Jidong; Usechak, Nicholas G.; Lin, Qiang

    2014-07-21

    We propose and demonstrate a convenient and sensitive technique for precise engineering of group-velocity dispersion in high-Q silicon microresonators. By accurately controlling the surface-oxidation thickness of silicon microdisk resonators, we are able to precisely manage the zero-dispersion wavelength, while simultaneously further improving the high optical quality of our devices, with the optical Q close to a million. The demonstrated dispersion management allows us to achieve parametric generation with precisely engineerable emission wavelengths, which shows great potential for application in integrated silicon nonlinear and quantum photonics.

  3. High Q-factor resonant photoluminescence from Ge-on-insulator micro-disks

    NASA Astrophysics Data System (ADS)

    Xu, Xuejun; Hashimoto, Hideaki; Yoshida, Keisuke; Sawano, Kentarou; Maruizumi, Takuya

    2016-05-01

    Micro-disk resonators with high Q-factor have been experimentally demonstrated on germanium-on-insulator (GOI). GOI substrates fabricated by direct wafer bonding show better crystal quality that germanium films directly grown on Si. Sharp resonant peaks with Q-factor around 1000-4000 have been observed from micro-disks fabricated on GOI substrate by low-temperature photoluminescence measurements. The light emission properties against pump laser power and device temperature are also investigated. Our results indicating that GOI micro-disks are promising resonators for low threshold, ultra-compact Ge lasers on Si.

  4. Single-frequency, 500-ns laser pulses generated by a passively Q-switched Nd laser

    NASA Astrophysics Data System (ADS)

    Jones, D. C.; Rockwell, D. A.

    1993-03-01

    Accounts are given of the construction and performance of a narrowband Q-switched oscillator that addresses requirements for heavy amplifier saturation as well as a degree of temporal pulse-shaping prior to oscillator beam injection into the amplifier chain that can avoid the severe temporal distortion imposed by amplifier saturation. This oscillator encompasses a lamp-pumped Cr:Nd:GSGG laser rod, a saturable absorber Q switch, and several etalon surfaces forming the output coupler. This device can be used in large baseline holography.

  5. Extremely high Q-factor mechanical modes in quartz bulk acoustic wave resonators at millikelvin temperature

    SciTech Connect

    Goryachev, M.; Creedon, D. L.; Ivanov, E. N.; Tobar, M. E.; Galliou, S.; Bourquin, R.

    2014-12-04

    We demonstrate that Bulk Acoustic Wave (BAW) quartz resonator cooled down to millikelvin temperatures are excellent building blocks for hybrid quantum systems with extremely long coherence times. Two overtones of the longitudinal mode at frequencies of 15.6 and 65.4 MHz demonstrate a maximum f.Q product of 7.8×10{sup 16} Hz. With this result, the Q-factor in such devices near the quantum ground state can be four orders of magnitude better than previously attained in other mechanical systems. Tested quartz resonators possess the ultra low acoustic losses crucial for electromagnetic cooling to the phonon ground state.

  6. Inflation Driven by q-de Sitter

    NASA Astrophysics Data System (ADS)

    Setare, M. R.; Momeni, D.; Kamali, V.; Myrzakulov, R.

    2016-02-01

    We propose a generalised de Sitter scale factor for the cosmology of early and late time universe, including single scalar field is called as inflaton. This form of scale factor has a free parameter q is called as nonextensivity parameter. When q = 1, the scale factor is de Sitter. This scale factor is an intermediate form between power-law and de Sitter. We study cosmology of such families. We show that both kinds of dark components, dark energy and dark matter simultaneously are described by this family of solutions. As a motivated idea, we investigate inflation in the framework of q-de Sitter. We consider three types of scenarios for inflation. In a single inflation scenario, we observe that, inflation ended without any specific ending inflation ϕ e n d , the spectral index and the associated running of the spectral index are n s - 1 ˜ -2 𝜖, α s ≡ 0. To end the inflation: we should have q={3}/{4}. We deduce that the inflation ends when the evolution of the scale factor is a( t) = e 3/4( t). With this scale factor there is no need to specify ϕ e n d . As an alternative to have inflation with ending point, We will study q-inflation model in the context of warm inflation. We propose two forms of damping term Γ. In the first case when Γ = Γ0, we show the scale invariant spectrum, (Harrison-Zeldovich spectrum, i.e. n s = 1) may be approximately presented by (q={9}/{10}, ~N=70). Also there is a range of values of R and n s which is compatible with the BICEP2 data where q={9}/{10}. In case Γ = Γ1 V( ϕ), it is observed that small values of a number of e-folds are assured for small values of q parameter. Also in this case, the scale-invariant spectrum may be represented by (q,N) = ({9}/{10},70). For q={9}/{10} a range of values of R and n s is compatible with the BICEP2 data. Consequently, the proposal of q-de Sitter is consistent with observational data. We observe that the non-extensivity parameter q plays a significant role in inflationary scenario.

  7. Quantum Dilogarithms and Partition q-Series

    NASA Astrophysics Data System (ADS)

    Kato, Akishi; Terashima, Yuji

    2015-08-01

    In our previous work (Kato and Terashima, Commun Math Phys. arXiv:1403.6569, 2014), we introduced the partition q-series for mutation loop γ—a loop in exchange quiver. In this paper, we show that for a certain class of mutation sequences, called reddening sequences, the graded version of partition q-series essentially coincides with the ordered product of quantum dilogarithm associated with each mutation; the partition q-series provides a state-sum description of combinatorial Donaldson-Thomas invariants introduced by Keller.

  8. The Q field, a variable quaternion basis

    SciTech Connect

    Efremov, A.P.

    1986-06-01

    The author introduces the concept of the Q field as a 2 x 2 matrix representation of the variable basis of vectors satisfying the rule of multiplication of quaternion imaginary numbers and as an element of the group of transformations of the basis preserving the invariance of this multiplication rule. The rule for projecting such matrices on a given direction is determined with the help of the characteristic functions of the matrices-vectors of the Q field. The differential structure of Q fields is studied and the theory developed is illustrated by an example of a model-topological classification of particles according to the magnitude of their spin.

  9. Rotating boson stars and Q-balls

    SciTech Connect

    Kleihaus, Burkhard; Kunz, Jutta; List, Meike

    2005-09-15

    We consider axially symmetric, rotating boson stars. Their flat-space limits represent spinning Q-balls. We discuss their properties and determine their domain of existence. Q-balls and boson stars are stationary solutions and exist only in a limited frequency range. The coupling to gravity gives rise to a spiral-like frequency dependence of the boson stars. We address the flat-space limit and the limit of strong gravitational coupling. For comparison we also determine the properties of spherically symmetric Q-balls and boson stars.

  10. The q-Laguerre matrix polynomials.

    PubMed

    Salem, Ahmed

    2016-01-01

    The Laguerre polynomials have been extended to Laguerre matrix polynomials by means of studying certain second-order matrix differential equation. In this paper, certain second-order matrix q-difference equation is investigated and solved. Its solution gives a generalized of the q-Laguerre polynomials in matrix variable. Four generating functions of this matrix polynomials are investigated. Two slightly different explicit forms are introduced. Three-term recurrence relation, Rodrigues-type formula and the q-orthogonality property are given. PMID:27190749

  11. CONTROL LIMITER DEVICE

    DOEpatents

    DeShong, J.A.

    1960-03-01

    A control-limiting device for monltoring a control system is described. The system comprises a conditionsensing device, a condition-varying device exerting a control over the condition, and a control means to actuate the condition-varying device. A control-limiting device integrates the total movement or other change of the condition-varying device over any interval of time during a continuum of overlapping periods of time, and if the tothl movement or change of the condition-varying device exceeds a preset value, the control- limiting device will switch the control of the operated apparatus from automatic to manual control.

  12. Hi-Q Rotor - Low Wind Speed Technology

    SciTech Connect

    Todd E. Mills; Judy Tatum

    2010-01-11

    The project objective was to optimize the performance of the Hi-Q Rotor. Early research funded by the California Energy Commission indicated the design might be advantageous over state-of-the-art turbines for collecting wind energy in low wind conditions. The Hi-Q Rotor is a new kind of rotor targeted for harvesting wind in Class 2, 3, and 4 sites, and has application in areas that are closer to cities, or 'load centers.' An advantage of the Hi-Q Rotor is that the rotor has non-conventional blade tips, producing less turbulence, and is quieter than standard wind turbine blades which is critical to the low-wind populated urban sites. Unlike state-of-the-art propeller type blades, the Hi-Q Rotor has six blades connected by end caps. In this phase of the research funded by DOE's Inventions and Innovation Program, the goal was to improve the current design by building a series of theoretical and numeric models, and composite prototypes to determine a best of class device. Development of the rotor was performed by aeronautical engineering and design firm, DARcorporation. From this investigation, an optimized design was determined and an 8-foot diameter, full-scale rotor was built and mounted using a Bergey LX-1 generator and furling system which were adapted to support the rotor. The Hi-Q Rotor was then tested side-by-side against the state-of-the-art Bergey XL-1 at the Alternative Energy Institute's Wind Test Center at West Texas State University for six weeks, and real time measurements of power generated were collected and compared. Early wind tunnel testing showed that the cut-in-speed of the Hi-Q rotor is much lower than a conventional tested HAWT enabling the Hi-Q Wind Turbine to begin collecting energy before a conventional HAWT has started spinning. Also, torque at low wind speeds for the Hi-Q Wind Turbine is higher than the tested conventional HAWT and enabled the wind turbine to generate power at lower wind speeds. Based on the data collected, the results of

  13. Microwave Reentrant Cavities for Quantum Devices

    NASA Astrophysics Data System (ADS)

    Carvalho, Natalia C.; Bourhill, Jeremy; Creedon, Daniel; Goryachev, Maxim; Galliou, Serge; Tobar, Michael

    A microwave reentrant cavity is a device able to provide a very sensitive high-Q microwave mode. Its design can be highly advantageous for electromechanical devices and quantum measurements. In this sense, a tuneable device based on a narrow-gap superconducting reentrant cavity is under development. The resonant frequency is able to be fine-tuned over a range larger than 500 MHz at 10 mK with an electrical Q-factor of 105. Such a cavity could possibly accommodate a transmon qubit to control and manipulate its quantum state. We are also working on the investigation of bulk acoustic wave (BAW) resonators in microwave reentrant cavities. BAW resonators offer a promising way to process quantum information through the coupling between microwaves and acoustic phonons. Thus, we are developing a device able to excite phonons through non-linearities and the piezoelectricity of the plano-convex quartz crystal. We will detail our experiments that work towards cooling gram scale phonon resonances to the quantum ground state. Funded by ARC Grant No. CE110001013 (Australia) and National Counsel of Technological and Scientific Development (Brazil).

  14. Measuring Visual Function Using the MultiQuity System: Comparison with an Established Device

    PubMed Central

    Nolan, John M.; Dennison, Jessica; Akuffo, Kwadwo Owusu; Kuchling, Robert; O'Regan, Graham

    2014-01-01

    Purpose. To compare measures of visual acuity (VA) and contrast sensitivity (CS) from the Thompson Xpert 2000 and MultiQuity (MiQ) devices. Methods. Corrected distance VA (CDVA) and CS were measured in the right eye of 73 subjects, on an established system (Thompson Xpert) and a novel system (MiQ 720). Regression was used to convert MiQ scores into the Thompson scale. Agreement between the converted MiQ and Thompson scores was investigated using standard agreement indices. Test-retest variability for both devices was also investigated, for a separate sample of 24 subjects. Results. For CDVA, agreement was strong between the MiQ and Thomson devices (accuracy = 0.993, precision = 0.889, CCC = 0.883). For CS, agreement was also strong (accuracy = 0.996, precision = 0.911, CCC = 0.907). Agreement was unaffected by demographic variables or by presence/absence of ocular pathology. Test-retest agreement indices for both devices were excellent: in the range 0.88–0.96 for CDVA and in the range 0.90–0.98 for CS. Conclusion. MiQ measurements exhibit strong agreement with corresponding Thomson measurements, and test-retest results are good for both devices. Agreement between the two devices is unaffected by age or ocular pathology. PMID:25580278

  15. De novo 11q13.4q14.3 tetrasomy with uniparental isodisomy for 11q14.3qter.

    PubMed

    Xiao, Bing; Xu, Huihui; Ye, Hui; Hu, Qin; Chen, Yingwei; Qiu, Wenjuan

    2015-10-01

    Interstitial triplications in conjunction with uniparental disomy (UPD) have been rarely reported. Here we report on a patient with de novo triplication at 11q13.4-q14.3 and UPD for 11q14.3-qter. Chromosomal analysis showed a karyotype of 46, XYqh+, der (11), and normal parental karyotypes. A single nucleotide polymorphism (SNP) array detected an 18.7 Mb copy number gain consistent with tetrasomy for 11q13.4-q14.3 (chr11:71,002,347 bp-89,725,167 bp, hg19) and absence of heterozygosity for a 45 Mb stretch on 11q and consistent with uniparental isodisomy at 11q14.3-qter (chr11:89,843,477 bp-134,930,689 bp, hg19) in our patient. FISH analysis using two probes on both sides of the tetrasomic region showed an inverted 11q13.4-q14.3 region between two direct oriented 11q13.4-q14.3 segments (11q13.4-q14.3::11q14.3-q13.4::11q13.4-qter). Previously reported features of duplication overlapping 11q13-q14 showed clinical variability. Our patient presented with some of those frequently described features, such as development delay, facial dysmorphism, and microcephaly but without congenital heart disease. Moreover, our patient had in addition a brain anomaly (absence of cerebellar vermis and partial absence of corpus callosum) which has not been reported. To our knowledge, this is the sixth patient reported an intrachromosomal triplication together with UPD. Interstitial 11q duplication overlapping 11q13-q14 is associated with intellectual disability/development delay, microcephaly, and facial dysmorphism but also other malformations. PMID:26061664

  16. Genetics Home Reference: 5q minus syndrome

    MedlinePlus

    ... and management of various health conditions: Diagnostic Tests Drug Therapy Surgery and Rehabilitation Genetic Counseling Palliative Care Related ... in patients with del(5q) myelodysplastic syndromes: linking mechanism of action to clinical outcomes. Ann Hematol. 2014 Jan;93( ...

  17. Characteristic classes associated to Q-bundles

    NASA Astrophysics Data System (ADS)

    Kotov, Alexei; Strobl, Thomas

    2015-10-01

    A Q-manifold is a graded manifold endowed with a vector field of degree 1 squaring to zero. We consider the notion of a Q-bundle, that is, a fiber bundle in the category of Q-manifolds. To each homotopy class of "gauge fields" (sections in the category of graded manifolds) and each cohomology class of a certain subcomplex of forms on the fiber we associate a cohomology class on the base. As any principal bundle yields canonically a Q-bundle, this construction generalizes Chern-Weil classes. Novel examples include cohomology classes that are locally de Rham differential of the integrands of topological sigma models obtained by the AKSZ-formalism in arbitrary dimensions. For Hamiltonian Poisson fibrations one obtains a characteristic 3-class in this manner. We also relate the framework to equivariant cohomology and Lecomte's characteristic classes of exact sequences of Lie algebras.

  18. Exploration Enterprise Workshop - Q&A

    NASA Video Gallery

    Q&A session from May 25, 2010, at the end of Day 1 of NASA's Exploration Enterprise Workshop held in Galveston, TX. The purpose of this workshop was to present NASA's initial plans for the potentia...

  19. Anti-C1q autoantibodies.

    PubMed

    Kallenberg, Cees G M

    2008-09-01

    Autoantibodies to complement components are associated with various diseases. Anti-C1q antibodies are present in all patients with hypocomplementemic urticarial vasculitis, but also, with varying prevalence, in other conditions. In SLE, these antibodies are neither sensitive nor specific for this condition. They occur, however, more frequently in (proliferative) lupus nephritis, particularly during active disease. Furthermore, levels of anti-C1q rise, in many cases, prior to a relapse of lupus nephritis, suggesting a pathogenic role for the autoantibodies. Indeed, experimental studies strongly support a pathogenic role for anti-C1q in immune complex-mediated renal disease. In addition, anti-C1q may interfere with the clearance of apoptotic cells, so influencing induction and expression of autoimmunity. PMID:18606253

  20. Chromosome 10q tetrasomy: First reported case

    SciTech Connect

    Blackston, R.D.; May, K.M.; Jones, F.D.

    1994-09-01

    While there are several reports of trisomy 10q (at least 35), we are not aware of previous cases of 10q tetrasomy. We present what we believe to be the initial report of such a case. R.J. is a 6 1/2 year old white male who presented with multiple dysmorphic features, marked articulation problems, hyperactivity, and developmental delays. He is the product of a term uncomplicated pregnancy. There was a normal spontaneous vaginal delivery with a birth weight of 6 lbs. 4oz. and length was 19 1/2 inch. Dysmorphic features include small size, an asymmetrically small head, low set ears with overfolded helixes, bilateral ptosis, downslanting eyes, right eye esotropia, prominent nose, asymmetric facies, high palate, mild pectus excavatum deformity of chest, and hyperextensible elbow joints. The patient is in special needs classes for mildly mentally handicapped students. Chromosome analysis at a resolution of 800 bands revealed a complex rearrangement of chromosomes 10 and 11. The segment 10q25.3 to q16.3 appears to be inverted and duplicated within the long arm of chromosome 10 at band q25.3 and the same segment of chromosome 10 is present on the terminal end of the short arm of chromosome 11. There is no visible loss of material from chromosome 11. Fluorescence in situ hybridization was performed with a chromosome 10 specific {open_quotes}paint{close_quotes} to confirm that all of the material on the abnormal 10 and the material on the terminal short arm of 11 was from chromosome 10. Thus, it appears that the segment 10q25.3 to q26.3 is present in four copies. Parental chromosome studies are normal. We compared findings which differ in that the case of 10q tetrasomy did not have prenatal growth deficiency, microphthalmia, cleft palate, digital anomalies, heart, or renal defects. Whereas most cases of 10q trisomy are said to have severe mental deficiency, our case of 10q tetrasomy was only mildly delayed. We report this first apparent cited case of 10q tetrasomy.

  1. An Unusual Manifestation of Q Fever: Peritonitis.

    PubMed

    Yılmaz, Gülden; Öztürk, Bengi; Memikoğlu, Osman; Coşkun, Belgin; Yalçı, Aysun; Metin, Özge; Ünal, Hatice; Kurt, Halil

    2015-01-01

    Q fever has rarely been reported and can be difficult to diagnose, especially in immunocompromised patients. In the present report, we describe an unusual case of Q fever that presented as peritonitis and was treated with long-term combination therapy with doxycycline, ciprofloxacin and rifampicin for five weeks in a patient who had been on peritoneal dialysis for six years due to hypertensive nephropathy. PMID:25899561

  2. Isochromosome 17q in Chronic Lymphocytic Leukemia.

    PubMed

    Alhourani, Eyad; Rincic, Martina; Melo, Joana B; Carreira, Isabel M; Glaser, Anita; Pohle, Beate; Schlie, Cordula; Liehr, Thomas

    2015-01-01

    In chronic lymphocytic leukemia (CLL), presence of acquired cytogenetic abnormalities may help to estimate prognosis. However, deletion of TP53 gene, which is associated with an aggressive course of the disease and poor prognosis along with a lack of response to treatment, is one of the alterations which may escape cytogenetic diagnoses in CLL. Thus, other techniques have emerged such as interphase fluorescence in situ hybridization (iFISH). Deletion of TP53 may but must not go together with the formation of an isochromosome i(17q); surprisingly this subgroup of patients was not in the focus of CLL studies yet. This study was about if presence of i(17q) could be indicative for a new subgroup in CLL with more adverse prognosis. As a result, TP53 deletion was detected in 18 out of 150 (12%) here studied CLL cases. Six of those cases (~33%) had the TP53 deletion accompanied by an i(17q). Interestingly, the cases with i(17q) showed a tendency towards more associated chromosomal aberrations. These findings may be the bases for follow-up studies in CLL patients with TP53 deletion with and without i(17q); it may be suggested that the i(17q) presents an even more adverse prognostic marker than TP53 deletion alone. PMID:26697230

  3. Isochromosome 17q in Chronic Lymphocytic Leukemia

    PubMed Central

    Alhourani, Eyad; Rincic, Martina; Melo, Joana B.; Carreira, Isabel M.; Glaser, Anita; Pohle, Beate; Schlie, Cordula; Liehr, Thomas

    2015-01-01

    In chronic lymphocytic leukemia (CLL), presence of acquired cytogenetic abnormalities may help to estimate prognosis. However, deletion of TP53 gene, which is associated with an aggressive course of the disease and poor prognosis along with a lack of response to treatment, is one of the alterations which may escape cytogenetic diagnoses in CLL. Thus, other techniques have emerged such as interphase fluorescence in situ hybridization (iFISH). Deletion of TP53 may but must not go together with the formation of an isochromosome i(17q); surprisingly this subgroup of patients was not in the focus of CLL studies yet. This study was about if presence of i(17q) could be indicative for a new subgroup in CLL with more adverse prognosis. As a result, TP53 deletion was detected in 18 out of 150 (12%) here studied CLL cases. Six of those cases (~33%) had the TP53 deletion accompanied by an i(17q). Interestingly, the cases with i(17q) showed a tendency towards more associated chromosomal aberrations. These findings may be the bases for follow-up studies in CLL patients with TP53 deletion with and without i(17q); it may be suggested that the i(17q) presents an even more adverse prognostic marker than TP53 deletion alone. PMID:26697230

  4. Genetics of Coenzyme Q10 Deficiency

    PubMed Central

    Doimo, Mara; Desbats, Maria A.; Cerqua, Cristina; Cassina, Matteo; Trevisson, Eva; Salviati, Leonardo

    2014-01-01

    Coenzyme Q10 (CoQ10) is an essential component of eukaryotic cells and is involved in crucial biochemical reactions such as the production of ATP in the mitochondrial respiratory chain, the biosynthesis of pyrimidines, and the modulation of apoptosis. CoQ10 requires at least 13 genes for its biosynthesis. Mutations in these genes cause primary CoQ10 deficiency, a clinically and genetically heterogeneous disorder. To date mutations in 8 genes (PDSS1, PDSS2, COQ2, COQ4, COQ6, ADCK3, ADCK4, and COQ9) have been associated with CoQ10 deficiency presenting with a wide variety of clinical manifestations. Onset can be at virtually any age, although pediatric forms are more common. Symptoms include those typical of respiratory chain disorders (encephalomyopathy, ataxia, lactic acidosis, deafness, retinitis pigmentosa, hypertrophic cardiomyopathy), but some (such as steroid-resistant nephrotic syndrome) are peculiar to this condition. The molecular bases of the clinical diversity of this condition are still unknown. It is of critical importance that physicians promptly recognize these disorders because most patients respond to oral administration of CoQ10. PMID:25126048

  5. Acampomelic campomelic dysplasia with de novo 5q;17q reciprocal translocation and severe phenotype.

    PubMed Central

    Savarirayan, R; Bankier, A

    1998-01-01

    Campomelic dysplasia (CD) is a rare skeletal malformation syndrome caused by mutations in the SRY related gene SOX9, mapped to 17q24.3-q25.1. A small proportion of cases are associated with structural rearrangements involving 17q and it has been proposed that this subgroup have a milder phenotype and better prognosis compared to those with mutations in the SOX9 gene. We report a severely affected infant with the acampomelic form of campomelic dysplasia, who died at 11 days and was found to have a de novo reciprocal translocation, 46,XX,t(5;17)(q15;q25.1). This is the second reported case of severe campomelic dysplasia associated with a structural rearrangement involving 17q and suggests that this subgroup of patients may not significantly differ from those without chromosomal rearrangements with regards to phenotype or prognosis. Images PMID:9678706

  6. The first patient with tandem duplication of 6q14q16: Molecular and phenotypic characterization.

    PubMed

    Sanmann, Jennifer N; Casas, Kari A; Bevilacqua, Jen; Bishay, Danielle L; Clark, Tanner; Van Dyke, A Zephyr; Leiferman, Patricia Crotwell; Reddi, Honey V; Starr, Lois J

    2016-09-01

    Duplications of the long arm of chromosome 6 have been previously reported in a limited number of patients; however, most reported duplications encompass regions of chromosome 6 distal to band q21. Duplications restricted to the proximal portion of 6q are rare. We report an 8-year-old male with a 16.4 megabase (Mb) tandem duplication of chromosome 6q14.1q16.1 (chr6:78950191-95395865; hg19) who exhibited dysmorphic facial features, seizures, global developmental delay, intellectual disability, autism spectrum disorder, sensorineural hearing loss, and immune deficiency. This patient refines and potentially expands the current, poorly-characterized phenotype associated with duplication of this proximal 6q region. We recommend a low threshold for a hearing evaluation beyond newborn screening and for pursuing an immune work-up in patients with similar 6q duplications. © 2016 Wiley Periodicals, Inc. PMID:27338032

  7. Implantable CMOS Biomedical Devices

    PubMed Central

    Ohta, Jun; Tokuda, Takashi; Sasagawa, Kiyotaka; Noda, Toshihiko

    2009-01-01

    The results of recent research on our implantable CMOS biomedical devices are reviewed. Topics include retinal prosthesis devices and deep-brain implantation devices for small animals. Fundamental device structures and characteristics as well as in vivo experiments are presented. PMID:22291554

  8. 18q- and 18q+ mosaicism in a mentally retarded boy

    SciTech Connect

    Ausems, M.G.E.M.; Bhola, S.L.; France, H.F. de; Post-Blok, C.A.; Hennekam, R.C.M.

    1994-11-15

    A mentally retarded boy was found to have an unusual chromosomal mosaicism [46,XY,del(18) (q22)/46,XY,iso psu dic(18)(q23)]. The clinical manifestations are compatible with the 18q- syndrome. The chromosome alteration was defined by high resolution banding and fluorescence in situ hybridization (FISH). A mechanism to explain the origin of the two cell lines is presented and discussed. 6 refs., 4 figs., 1 tab.

  9. [Hplc estimation of coenzyme Q(10) redox status in plasma after intravenous coenzyme Q(10) administration].

    PubMed

    Kalenikova, E I; Kharitonova, E V; Gorodetskaya, E A; Tokareva, O G; Medvedev, O S

    2015-01-01

    The pharmacokinetics of the total pool of coenzyme Q(10) (Co(10)), its oxidized (ubiquinone) and reduced (ubiquinol, CoQ(10)H₂) forms have been investigated in rats plasma during 48 h after a single intravenous injection of a solution of solubilized CoQ(10) (10 mg/kg) to rats. Plasma levels of CoQ(10) were determined by HPLC with spectrophotometric and coulometric detection. In plasma samples taken during the first minutes after the CoQ(10) intravenous injection, the total pool of coenzyme Q(10) and proportion of CoQ(10)H₂ remained unchanged during two weeks of storage at -20°C. The kinetic curve of the total pool of coenzyme Q(10) corresponds to a one-part model (R² = 0.9932), while the corresponding curve of its oxidized form fits to the two-part model. During the first minutes after the injection a significant portion of plasma ubiquinone undergoes reduction, and after 7 h the concentration of ubiquinol predominates. The decrease in the total plasma coenzyme Q(10) content was accompanied by the gradual increase in plasma ubiquinol, which represented about 90% of total plasma CoQ(10) by the end of the first day. The results of this study demonstrate the ability of the organism to transform high concentrations of the oxidized form of CoQ(10) into the effective antioxidant (reduced) form and justify prospects of the development of parenteral dosage forms of CoQ(10) for the use in the treatment of acute pathological conditions. PMID:25762606

  10. A Monte Carlo study of the light q sup 2 q sup 2 system

    SciTech Connect

    Grondin, G. . Dept. of Physics Oak Ridge National Lab., TN )

    1991-01-01

    We present results from a Guided Random Walk Monte Carlo simulation of the light (q = u, d) q{sup 2}{bar q}{sup 2} system in a Coulomb-plus-linear quark potential model using an Intel iPSC/860 hypercube. We find evidence for no bound states below the vector-vector threshold in the (J,I) = (2,2) and (2,0) sector. 14 refs., 2 figs.

  11. The q-Laplace operator and q-harmonic polynomials on the quantum vector space

    NASA Astrophysics Data System (ADS)

    Iorgov, N. Z.; Klimyk, A. U.

    2001-03-01

    The aim of this paper is to study q-harmonic polynomials on the quantum vector space generated by q-commuting elements x1,x2,…,xn. They are defined as solutions of the equation Δqp=0, where p is a polynomial in x1,x2,…,xn and the q-Laplace operator Δq is determined in terms of q-derivatives. The projector Hm:Am→Hm is constructed, where Am and Hm are the spaces of homogeneous (of degree m) polynomials and q-harmonic polynomials, respectively. By using these projectors, a q-analog of classical associated spherical harmonics is constructed. They constitute an orthonormal basis of Hm. A q-analog of separation of variables is given. Representations of the nonstandard q-deformed algebra Uq'(son) [which plays the role of the rotation group SO(n) in the case of classical harmonic polynomials] on the spaces Hm are explicitly constructed.

  12. Robertsonian (15q;15q) translocation in a child with Angelman syndrome: Evidence of uniparental disomy

    SciTech Connect

    Tonk, V.; Schultz, R.A.; Wilson, G.N.; Schultz, R.A.

    1996-12-30

    A balanced Robertsonian translocation 45,XY,t(15q15q) was detected in a patient with mental retardation, microcephaly, and hypertonia. Deletion of the 15q11q13 region was unlikely based on fluorescence in situ hybridization studies that revealed hybridization of appropriate DNA probes to both arms of the Robertsonian chromosome. Inheritance of alleles from 13 highly polymorphic DNA markers on chromosome 15 showed paternal uniparental isodisomy. The clinical, cytogenetic, and molecular results are consistent with a diagnosis of Angelman syndrome. 8 refs., 3 figs.

  13. Fluid sampling device

    NASA Technical Reports Server (NTRS)

    Studenick, D. K. (Inventor)

    1977-01-01

    An inlet leak is described for sampling gases, more specifically, for selectively sampling multiple fluids. This fluid sampling device includes a support frame. A plurality of fluid inlet devices extend through the support frame and each of the fluid inlet devices include a longitudinal aperture. An opening device that is responsive to a control signal selectively opens the aperture to allow fluid passage. A closing device that is responsive to another control signal selectively closes the aperture for terminating further fluid flow.

  14. Theory of the optimally coupled Q-switched laser

    NASA Technical Reports Server (NTRS)

    Degnan, John J.

    1989-01-01

    The general equations describing Q-switched laser operation are transcendental in nature and require numerical solutions, which greatly complicates the optimization of real devices. Here, it is shown that, using the mathematical technique of Lagrange multipliers, one can derive simple analytic expressions for all of the key parameters of the optimally coupled laser, i.e., one which uses an optimum reflector to obtain maximum laser efficiency for a given pump level. These parameters can all be expressed as functions of a single dimensionless variable z, defined as the ratio of the unsaturated small-signal gain to the dissipative (nonuseful) optical loss, multiplied by a few simple constants. Laser design tradeoff studies and performance projections can be accomplished quickly with the help of several graphs and a simple hand calculator. Sample calculations for a high-gain Nd:YAG and a low-gain alexandrite laser are presented as illustrations of the technique.

  15. Studies on a Q/A selector for the SECRAL electron cyclotron resonance ion source

    SciTech Connect

    Yang, Y.; Sun, L. T.; Feng, Y. C.; Fang, X.; Lu, W.; Zhang, W. H.; Cao, Y.; Zhang, X. Z.; Zhao, H. W.

    2014-08-15

    Electron cyclotron resonance ion sources are widely used in heavy ion accelerators in the world because they are capable of producing high current beams of highly charged ions. However, the design of the Q/A selector system for these devices is challenging, because it must have a sufficient ion resolution while controlling the beam emittance growth. Moreover, this system has to be matched for a wide range of ion beam species with different intensities. In this paper, research on the Q/A selector system at the SECRAL (Superconducting Electron Cyclotron Resonance ion source with Advanced design in Lanzhou) platform both in experiment and simulation is presented. Based on this study, a new Q/A selector system has been designed for SECRAL II. The features of the new design including beam simulations are also presented.

  16. Studies on a Q/A selector for the SECRAL electron cyclotron resonance ion source.

    PubMed

    Yang, Y; Sun, L T; Feng, Y C; Fang, X; Lu, W; Zhang, W H; Cao, Y; Zhang, X Z; Zhao, H W

    2014-08-01

    Electron cyclotron resonance ion sources are widely used in heavy ion accelerators in the world because they are capable of producing high current beams of highly charged ions. However, the design of the Q/A selector system for these devices is challenging, because it must have a sufficient ion resolution while controlling the beam emittance growth. Moreover, this system has to be matched for a wide range of ion beam species with different intensities. In this paper, research on the Q/A selector system at the SECRAL (Superconducting Electron Cyclotron Resonance ion source with Advanced design in Lanzhou) platform both in experiment and simulation is presented. Based on this study, a new Q/A selector system has been designed for SECRAL II. The features of the new design including beam simulations are also presented. PMID:25173256

  17. Characterization of implantable microfabricated fluid delivery devices.

    PubMed

    Rathnasingham, Ruben; Kipke, Daryl R; Bledsoe, Sanford C; McLaren, John D

    2004-01-01

    The formal characterization of the performance of microfluidic delivery devices is crucial for reliable in vivo application. A comprehensive laboratory technique was developed and used to optimize, calibrate and validate microfabricated fluid delivery devices. In vivo experiments were carried out to verify the accuracy and reliability of the pressure driven devices. Acute guinea pig experiments were conducted to measure the response to alpha-amino-3-hydroxy-5-methyl-4-isoxalone propionic acid, an excitatory neurotransmitter, at multiple locations in the inferior colliculus. A nondimensional parameter, Q, was successfully used to classify devices in terms of geometry alone (i.e., independent of fluid properties). Functional devices exhibited long-term linearity and reliability in delivering single phase, Newtonian fluids, in discrete volumes with a resolution of 500 picoliters at less than 0.45 lbf/in2 (30 mbar) pressure drop. Results for non-Newtonian fluids are not presented here. The acute results showed a proportional increase in the firing rate for delivered volumes of 2 nL up to 10 nL (at rates of between 0.1 and 1 nL/s). Flow characteristics are maintained during acute experiments and post-implant. A control experiment conducted with Ringer solution produced negligible effects, suggesting the results to be truly pharmacological. The experimental techniques employed have proven to be reliable and will be used for future calibration and testing of next generation chronic microfluidic delivery devices. PMID:14723503

  18. Q c and Q S wave attenuation of South African earthquakes

    NASA Astrophysics Data System (ADS)

    Brandt, Martin B. C.

    2016-04-01

    Quality factor Q, which describes the attenuation of seismic waves with distance, was determined for South Africa using data recorded by the South African National Seismograph Network. Because of an objective paucity of seismicity in South Africa and modernisation of the seismograph network only in 2007, I carried out a coda wave decay analysis on only 13 tectonic earthquakes and 7 mine-related events for the magnitude range 3.6 ≤ M L ≤ 4.4. Up to five seismograph stations were utilised to determine Q c for frequencies at 2, 4, 8 and 16 Hz resulting in 84 individual measurements. The constants Q 0 and α were determined for the attenuation relation Q c( f) = Q 0 f α . The result was Q 0 = 396 ± 29 and α = 0.72 ± 0.04 for a lapse time of 1.9*( t s - t 0) (time from origin time t 0 to the start of coda analysis window is 1.9 times the S-travel time, t s) and a coda window length of 80 s. This lapse time and coda window length were found to fit the most individual frequencies for a signal-to-noise ratio of at least 3 and a minimum absolute correlation coefficient for the envelope of 0.5. For a positive correlation coefficient, the envelope amplitude increases with time and Q c was not calculated. The derived Q c was verified using the spectral ratio method on a smaller data set consisting of nine earthquakes and one mine-related event recorded by up to four seismograph stations. Since the spectral ratio method requires absolute amplitudes in its calculations, site response tests were performed to select four appropriate stations without soil amplification and/or signal distortion. The result obtained for Q S was Q 0 = 391 ± 130 and α = 0.60 ± 0.16, which agrees well with the coda Q c result.

  19. High-Q mid-infrared thermal emitters operating with high power-utilization efficiency.

    PubMed

    Inoue, Takuya; De Zoysa, Menaka; Asano, Takashi; Noda, Susumu

    2016-06-27

    We demonstrate a single-mode high-Q (Q>100) mid-infrared thermal emitter operating with high power-utilization efficiency. The emitter consists of a rod-type photonic crystal (PC) slab interacting with GaAs/AlGaAs multiple quantum wells (MQWs), a GaAs substrate frame supporting the PC slab, and electric wires for Joule heating of the device. We carefully design the structure of the PC slab and the supporting frame/wires to minimize unwanted thermal losses and realize narrowband thermal emission having a peak intensity, under a given electrical input power, that is an order of magnitude higher than that of a reference blackbody emitter due to the efficient increase of the device temperature. PMID:27410661

  20. Support Loss and Q Factor Enhancement for a Rocking Mass Microgyroscope

    PubMed Central

    Wang, Xiong; Xiao, Dingbang; Zhou, Zelong; Wu, Xuezhong; Chen, Zhihua; Li, Shengyi

    2011-01-01

    A rocking mass gyroscope (RMG) is a kind of vibrating mass gyroscope with high sensitivity, whose driving mode and sensing mode are completely uniform. MEMS RMG devices are a research hotspot now because they have the potential to be used in space applications. Support loss is the dominant energy loss mechanism influencing their high sensitivity. An accurate analytical model of support loss for RMGs is presented to enhance their Q factors. The anchor type and support loss mechanism of an RMG are analyzed. Firstly, the support loads, powers flowing into support structure, and vibration energy of an RMG are all developed. Then the analytical model of support loss for the RMG is developed, and its sensitivities to the main structural parameters are also analyzed. High-Q design guidelines for rocking mass microgyroscopes are deduced. Finally, the analytical model is validated by the experimental data and the data from the existing literature. The thicknesses of the prototypes are reduced from 240 μm to 60 μm, while Q factors increase from less than 150 to more than 800. The derived model is general and applicable to various beam resonators, providing significant insight to the design of high-Q MEMS devices. PMID:22163727

  1. Investigation of mechanically Q-switched lasers

    NASA Astrophysics Data System (ADS)

    Cole, Brian; Goldberg, Lew; Hough, Nathaniel; Nettleton, John

    2015-02-01

    Using a resonant scanner mirror Q-switch to provide a time varying change in cavity alignment, 1535nm lasers based on Er/Yb-doped glass and 1064nm lasers based on Nd:YAG were evaluated. Using a side pumping architecture, the Er/Yb glass laser used a compact mechanical Q-switch with a mirror rotation rate of 330 Rad/s, enabling generation of <3 mJ pulses with a pulse width of 16ns. The laser output was a diffraction limited TEM00 mode. A mechanical Q-switch based on a MEMS tilting mirror was also used; its performance in a laser cavity was found to be similar to the resonant mirror. The technique of mechanical Q-switching was also extended to a side pumped Nd:YAG laser (mirror sweep rate of 1300 Rad/s), enabling generation of Q-switched pulses of <30mJ and 25ns duration. The far-field divergence showed this laser to be highly multi-moded within the pump plane, with a measured beam-product-parameter greater than 30 mm-mRad.

  2. k and q Dedicated to Paul Callaghan

    NASA Astrophysics Data System (ADS)

    Blümich, Bernhard

    2016-06-01

    The symbols k and q denote wave numbers in scattering experiments as well as in NMR imaging. Their exploration in NMR is intimately linked to the legacy of Paul Callaghan with his books Magnetic Resonance Microscopy and Translational Dynamics & Magnetic Resonance (Oxford University Press, Oxford 1991 and 2011) placing their focus with their titles on k and q, respectively. Some aspects of k and q have been revisited in the Paul Callaghan lecture of the author at the ISMAR Conference in Shanghai in 2015, which are reviewed here. In particular, there are two definitions of q, one relating to diffusive displacement (q) and the other to coherent flow (qv). Concerning the latter, it turns out, that in the short gradient pulse limit, the common anti-phase pulsed field-gradient scheme can be replaced with schemes employing three and more gradient pulses, which derive from differentiation rules in numerical analysis. Practical gradient modulation schemes with finite gradient pulse widths follow from these to measure velocity with improved accuracy. This approach can be expanded to acceleration and higher order transport coefficients with applications to measurements of flow and potentially also restricted diffusion.

  3. Q-FANSTM for general aviation aircraft

    NASA Technical Reports Server (NTRS)

    Worobel, R.; Mayo, M. G.

    1973-01-01

    Continued growth of general aviation over the next 10 to 15 years is dependent on continuing improvement in aircraft safety, utility, performance and cost. Moreover, these advanced aircraft will need to conform to expected government regulations controlling propulsion system emissions and noise levels. An attractive compact low noise propulsor concept, the Q-FANTM when matched to piston, rotary combustion, or gas turbine engines opens up the exciting prospect of new, cleaner airframe designs for the next generation of general aviation aircraft which will provide these improvements and meet the expected noise and pollution restriction of the 1980 time period. New Q-FAN methodology which was derived to predict Q-FAN noise, weight and cost is presented. Based on this methodology Q-FAN propulsion system performance, weight, noise, and cost trends are discussed. Then the impact of this propulsion system type on the complete aircraft is investigated for several representative aircraft size categories. Finally, example conceptual designs for Q-FAN/engine integration and aircraft installations are presented.

  4. k and q Dedicated to Paul Callaghan.

    PubMed

    Blümich, Bernhard

    2016-06-01

    The symbols k and q denote wave numbers in scattering experiments as well as in NMR imaging. Their exploration in NMR is intimately linked to the legacy of Paul Callaghan with his books Magnetic Resonance Microscopy and Translational Dynamics & Magnetic Resonance (Oxford University Press, Oxford 1991 and 2011) placing their focus with their titles on k and q, respectively. Some aspects of k and q have been revisited in the Paul Callaghan lecture of the author at the ISMAR Conference in Shanghai in 2015, which are reviewed here. In particular, there are two definitions of q, one relating to diffusive displacement (q) and the other to coherent flow (qv). Concerning the latter, it turns out, that in the short gradient pulse limit, the common anti-phase pulsed field-gradient scheme can be replaced with schemes employing three and more gradient pulses, which derive from differentiation rules in numerical analysis. Practical gradient modulation schemes with finite gradient pulse widths follow from these to measure velocity with improved accuracy. This approach can be expanded to acceleration and higher order transport coefficients with applications to measurements of flow and potentially also restricted diffusion. PMID:27067190

  5. A random Q-switched fiber laser.

    PubMed

    Tang, Yulong; Xu, Jianqiu

    2015-01-01

    Extensive studies have been performed on random lasers in which multiple-scattering feedback is used to generate coherent emission. Q-switching and mode-locking are well-known routes for achieving high peak power output in conventional lasers. However, in random lasers, the ubiquitous random cavities that are formed by multiple scattering inhibit energy storage, making Q-switching impossible. In this paper, widespread Rayleigh scattering arising from the intrinsic micro-scale refractive-index irregularities of fiber cores is used to form random cavities along the fiber. The Q-factor of the cavity is rapidly increased by stimulated Brillouin scattering just after the spontaneous emission is enhanced by random cavity resonances, resulting in random Q-switched pulses with high brightness and high peak power. This report is the first observation of high-brightness random Q-switched laser emission and is expected to stimulate new areas of scientific research and applications, including encryption, remote three-dimensional random imaging and the simulation of stellar lasing. PMID:25797520

  6. Measurement of the Q2-evolution of the Bjorken integral at low Q2

    SciTech Connect

    Alexandre Deur

    2004-04-01

    We report on the extraction of the Q2-dependence of the Bjorken sum between 0.16 < Q2 < 1.1 GeV2. A twist analysis performed on these data shows that the higher twist corrections are small due to a cancellation between the twist-4 and 6 terms. The extraction of an effective strong coupling constant is discussed.

  7. Interstitial deletion of the long arm of chromosome 2: del(2)(q31q33).

    PubMed

    Al-Awadi, S A; Farag, T I; Naguib, K; Teebi, A; Cuschieri, A; Al-Othman, S; Sundareshan, T S

    1983-12-01

    A child with a de novo interstitial deletion, 46,XX,del(2)(q31q33), is described. Clinical features included psychomotor retardation, hypotonia, microcephaly, hypertelorism, downward slanting palpebral fissures, macrostomia, cleft palate, micrognathia, abnormal ears, overlapping fingers, simian creases, and rocker bottom feet. PMID:6655673

  8. 40 CFR Table 1 to Subpart Q of... - General Provisions Applicability to Subpart Q

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 9 2010-07-01 2010-07-01 false General Provisions Applicability to Subpart Q 1 Table 1 to Subpart Q of Part 63 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) NATIONAL EMISSION STANDARDS FOR HAZARDOUS AIR POLLUTANTS FOR SOURCE CATEGORIES National Emission Standards...

  9. Nonclassical Properties of Q-Deformed Superposition Light Field State

    NASA Technical Reports Server (NTRS)

    Ren, Min; Shenggui, Wang; Ma, Aiqun; Jiang, Zhuohong

    1996-01-01

    In this paper, the squeezing effect, the bunching effect and the anti-bunching effect of the superposition light field state which involving q-deformation vacuum state and q-Glauber coherent state are studied, the controllable q-parameter of the squeezing effect, the bunching effect and the anti-bunching effect of q-deformed superposition light field state are obtained.

  10. [Difficult airway management using the air-Q in a patient with Klippel-Feil syndrome].

    PubMed

    Komasawa, Nobuyasu; Miyazaki, Shinichiro; Soen, Masako; Kusunoki, Tomohiro; Tatsumi, Shinichi; Minami, Toshiaki

    2014-06-01

    Patients with Klippel-Feil syndrome (KFS) frequently encounter difficult airway management due to skeletal abnormalities, including fusion of two or more vertebrae and short neck. We report successful tracheal intubation using the air-Q supraglottic airway device (air-Q). A 46-year-old woman (height, 149 cm; weight, 62 kg) with KFS was scheduled to undergo vertebral arch plasty for cervical spondylotic myelopathy. She could open her mouth sufficiently but could not tilt her head due to C1-3 fusion. Following administration of fentanyl 100 microg and propofol 120 mg, mask ventilation was achieved with jaw thrust maneuver. We then administered rocuronium 50 mg for immobilization and attempted tracheal intubation using the Pentax-AWS Airwayscope with a thin pediatric Intlock. However, we could not target the glottis, and ventilation via a size 3 i-gel or size 3.5 air-Q was unsuccessful. Using a size 2.5 air-Q, sufficient ventilation was finally achieved. We performed fiberoptic tracheal intubation through the air-Q using a tube with an internal diameter of 6.0-mm. We then exchanged the 6.0-mm tracheal tube with a 7.0-mm spiral tube using a 10 Fr tracheal tube introducer. PMID:24979859

  11. Central 22q11.2 deletions.

    PubMed

    Rump, Patrick; de Leeuw, Nicole; van Essen, Anthonie J; Verschuuren-Bemelmans, Corien C; Veenstra-Knol, Hermine E; Swinkels, Mariëlle E M; Oostdijk, Wilma; Ruivenkamp, Claudia; Reardon, Willie; de Munnik, Sonja; Ruiter, Mariken; Frumkin, Ayala; Lev, Dorit; Evers, Christina; Sikkema-Raddatz, Birgit; Dijkhuizen, Trijnie; van Ravenswaaij-Arts, Conny M

    2014-11-01

    22q11.2 deletion syndrome is one of the most common microdeletion syndromes. Most patients have a deletion resulting from a recombination of low copy repeat blocks LCR22-A and LCR22-D. Loss of the TBX1 gene is considered the most important cause of the phenotype. A limited number of patients with smaller, overlapping deletions distal to the TBX1 locus have been described in the literature. In these patients, the CRKL gene is deleted. Haploinsufficiency of this gene has also been implicated in the pathogenesis of 22q11.2 deletion syndrome. To distinguish these deletions (comprising the LCR22-B to LCR22-D region) from the more distal 22q11.2 deletions (located beyond LCR22-D), we propose the term "central 22q11.2 deletions". In the present study we report on 27 new patients with such a deletion. Together with information on previously published cases, we review the clinical findings of 52 patients. The prevalence of congenital heart anomalies and the frequency of de novo deletions in patients with a central deletion are substantially lower than in patients with a common or distal 22q11.2 deletion. Renal and urinary tract malformations, developmental delays, cognitive impairments and behavioral problems seem to be equally frequent as in patients with a common deletion. None of the patients had a cleft palate. Patients with a deletion that also encompassed the MAPK1 gene, located just distal to LCR22-D, have a different and more severe phenotype, characterized by a higher prevalence of congenital heart anomalies, growth restriction and microcephaly. Our results further elucidate genotype-phenotype correlations in 22q11.2 deletion syndrome spectrum. PMID:25123976

  12. Distinctive Phenotype in 9 Patients with Deletion of Chromosome 1q24-q25

    PubMed Central

    Burkardt, Deepika D’Cunha; Rosenfeld, Jill A.; Helgeson, Maria; Angle, Brad; Banks, Valerie; Smith, Wendy; Gripp, Karen W.; Moline, Jessica; Moran, Rocio; Niyazov, Dmitriy M.; Stevens, Cathy; Zackai, Elaine; Lebel, Robert Roger; Ashley, Douglas; Kramer, Nancy; Lachman, Ralph S.; Graham, John M.

    2011-01-01

    Reports of individuals with deletions of 1q24→q25 share common features of prenatal onset growth deficiency, microcephaly, small hands and feet, dysmorphic face and severe cognitive deficits. We report nine individuals with 1q24q25 deletions, who show distinctive features of a clinically recognizable 1q24q25 microdeletion syndrome: prenatal-onset microcephaly and proportionate growth deficiency, severe cognitive disability, small hands and feet with distinctive brachydactyly, single transverse palmar flexion creases, fifth finger clinodactyly and distinctive facial features: upper eyelid fullness, small ears, short nose with bulbous nasal tip, tented upper lip, and micrognathia. Radiographs demonstrate disharmonic osseous maturation with markedly delayed bone age. Occasional features include cleft lip and/or palate, cryptorchidism, brain and spinal cord defects, and seizures. Using oligonucleotide-based array comparative genomic hybridization, we defined the critical deletion region as 1.9 Mb at 1q24.3q25.1 (chr1: 170135865–172099327, hg18 coordinates), containing 13 genes and including CENPL, which encodes centromeric protein L, a protein essential for proper kinetochore function and mitotic progression. The growth deficiency in this syndrome is similar to what is seen in other types of primordial short stature with microcephaly, such as Majewski osteodysplastic primordial dwarfism, type II (MOPD2) and Seckel syndrome, which result from loss-of-function mutations in genes coding for centrosomal proteins. DNM3 is also in the deleted region and expressed in the brain, where it participates in the Shank-Homer complex and increases synaptic strength. Therefore, DNM3 is a candidate for the cognitive disability, and CENPL is a candidate for growth deficiency in this 1q24q25 microdeletion syndrome. PMID:21548129

  13. Investigation of 15q11-q13, 16p11.2 and 22q13 CNVs in Autism Spectrum Disorder Brazilian Individuals with and without Epilepsy

    PubMed Central

    Moreira, Danielle P.; Griesi-Oliveira, Karina; Bossolani-Martins, Ana L.; Lourenço, Naila C. V.; Takahashi, Vanessa N. O.; da Rocha, Kátia M.; Moreira, Eloisa S.; Vadasz, Estevão; Meira, Joanna Goes Castro; Bertola, Debora; Halloran, Eoghan O’; Magalhães, Tiago R.; Fett-Conte, Agnes C.; Passos-Bueno, Maria Rita

    2014-01-01

    Copy number variations (CNVs) are an important cause of ASD and those located at 15q11-q13, 16p11.2 and 22q13 have been reported as the most frequent. These CNVs exhibit variable clinical expressivity and those at 15q11-q13 and 16p11.2 also show incomplete penetrance. In the present work, through multiplex ligation-dependent probe amplification (MLPA) analysis of 531 ethnically admixed ASD-affected Brazilian individuals, we found that the combined prevalence of the 15q11-q13, 16p11.2 and 22q13 CNVs is 2.1% (11/531). Parental origin could be determined in 8 of the affected individuals, and revealed that 4 of the CNVs represent de novo events. Based on CNV prediction analysis from genome-wide SNP arrays, the size of those CNVs ranged from 206 kb to 2.27 Mb and those at 15q11-q13 were limited to the 15q13.3 region. In addition, this analysis also revealed 6 additional CNVs in 5 out of 11 affected individuals. Finally, we observed that the combined prevalence of CNVs at 15q13.3 and 22q13 in ASD-affected individuals with epilepsy (6.4%) was higher than that in ASD-affected individuals without epilepsy (1.3%; p<0.014). Therefore, our data show that the prevalence of CNVs at 15q13.3, 16p11.2 and 22q13 in Brazilian ASD-affected individuals is comparable to that estimated for ASD-affected individuals of pure or predominant European ancestry. Also, it suggests that the likelihood of a greater number of positive MLPA results might be found for the 15q13.3 and 22q13 regions by prioritizing ASD-affected individuals with epilepsy. PMID:25255310

  14. Investigation of 15q11-q13, 16p11.2 and 22q13 CNVs in autism spectrum disorder Brazilian individuals with and without epilepsy.

    PubMed

    Moreira, Danielle P; Griesi-Oliveira, Karina; Bossolani-Martins, Ana L; Lourenço, Naila C V; Takahashi, Vanessa N O; da Rocha, Kátia M; Moreira, Eloisa S; Vadasz, Estevão; Meira, Joanna Goes Castro; Bertola, Debora; O'Halloran, Eoghan; Magalhães, Tiago R; Fett-Conte, Agnes C; Passos-Bueno, Maria Rita

    2014-01-01

    Copy number variations (CNVs) are an important cause of ASD and those located at 15q11-q13, 16p11.2 and 22q13 have been reported as the most frequent. These CNVs exhibit variable clinical expressivity and those at 15q11-q13 and 16p11.2 also show incomplete penetrance. In the present work, through multiplex ligation-dependent probe amplification (MLPA) analysis of 531 ethnically admixed ASD-affected Brazilian individuals, we found that the combined prevalence of the 15q11-q13, 16p11.2 and 22q13 CNVs is 2.1% (11/531). Parental origin could be determined in 8 of the affected individuals, and revealed that 4 of the CNVs represent de novo events. Based on CNV prediction analysis from genome-wide SNP arrays, the size of those CNVs ranged from 206 kb to 2.27 Mb and those at 15q11-q13 were limited to the 15q13.3 region. In addition, this analysis also revealed 6 additional CNVs in 5 out of 11 affected individuals. Finally, we observed that the combined prevalence of CNVs at 15q13.3 and 22q13 in ASD-affected individuals with epilepsy (6.4%) was higher than that in ASD-affected individuals without epilepsy (1.3%; p<0.014). Therefore, our data show that the prevalence of CNVs at 15q13.3, 16p11.2 and 22q13 in Brazilian ASD-affected individuals is comparable to that estimated for ASD-affected individuals of pure or predominant European ancestry. Also, it suggests that the likelihood of a greater number of positive MLPA results might be found for the 15q13.3 and 22q13 regions by prioritizing ASD-affected individuals with epilepsy. PMID:25255310

  15. Fuzzy Q-Learning for Generalization of Reinforcement Learning

    NASA Technical Reports Server (NTRS)

    Berenji, Hamid R.

    1996-01-01

    Fuzzy Q-Learning, introduced earlier by the author, is an extension of Q-Learning into fuzzy environments. GARIC is a methodology for fuzzy reinforcement learning. In this paper, we introduce GARIC-Q, a new method for doing incremental Dynamic Programming using a society of intelligent agents which are controlled at the top level by Fuzzy Q-Learning and at the local level, each agent learns and operates based on GARIC. GARIC-Q improves the speed and applicability of Fuzzy Q-Learning through generalization of input space by using fuzzy rules and bridges the gap between Q-Learning and rule based intelligent systems.

  16. Fractional exhaled nitric oxide in childhood is associated with 17q11.2-q12 and 17q12-q21 variants

    PubMed Central

    Timpson, Nicolas J; Salam, Muhammad T; Standl, Marie; Curtin, John A; Genuneit, Jon; Kerhof, Marjan; Kreiner-Møller, Eskil; Cáceres, Alejandro; Gref, Anna; Liang, Liming L; Taal, H Rob; Bouzigon, Emmanuelle; Demenais, Florence; Nadif, Rachel; Ober, Carole; Thompson, Emma E; Estrada, Karol; Hofman, Albert; Uitterlinden, André G; van Duijn, Cornélia; Rivadeneira, Fernando; Li, Xia; Eckel, Sandrah P; Berhane, Kiros; Gauderman, W James; Granell, Raquel; Evans, David M; St Pourcain, Beate; McArdle, Wendy; Kemp, John P; Smith, George Davey; Tiesler, Carla MT; Flexeder, Claudia; Simpson, Angela; Murray, Clare S; Fuchs, Oliver; Postma, Dirkje S; Bønnelykke, Klaus; Torrent, Maties; Andersson, Martin; Sleiman, Patrick; Hakonarson, Hakon; Cookson, William O; Moffatt, Miriam F; Paternoster, Lavinia; Melén, Erik; Sunyer, Jordi; Bisgaard, Hans; Koppelman, Gerard H; Ege, Markus; Custovic, Adnan; Heinrich, Joachim; Gilliland, Frank D; Henderson, Alexander J; Jaddoe, Vincent WV; de Jongste, Johan C

    2014-01-01

    Background The fractional concentration of nitric oxide in exhaled air (FeNO) is a biomarker of eosinophilic airway inflammation and associated with childhood asthma. Identification of common genetic variants associated with childhood FeNO may help to define biological mechanisms related to specific asthma phenotypes. Objective To identify genetic variants associated with childhood FeNO, and their relation with asthma. Methods FeNO was measured in children aged 5 to 15 years. In 14 genome-wide association (GWA) studies (N = 8,858), we examined the associations of ~2.5 million single nucleotide polymorphisms (SNPs) with FeNO. Subsequently, we assessed whether significant SNPs were expression quantitative trait loci (eQTLs) in genome-wide expression datasets of lymphoblastoid cell lines (N = 1,830), and were related with asthma in a previously published GWA dataset (cases: n=10,365; controls: n=16,110). Results We identified 3 SNPs associated with FeNO: rs3751972 in LYR motif containing 9 (LYRM9) (P = 1.97×10−10) and rs944722 in inducible nitric oxide synthase 2 (NOS2) (P = 1.28×10−9) both located at 17q11.2-q12, and rs8069176 near gasdermin B (GSDMB) (P = 1.88×10−8) at 17q12-q21. We found a cis eQTL for the transcript soluble galactoside-binding lectin 9 (LGALS9) that is in linkage disequilibrium with rs944722. Rs8069176 was associated with GSDMB and ORM1-like 3 (ORMDL3) expression. Rs8069176 at 17q12-q21, and not rs3751972 and rs944722 at 17q11.2-q12, were associated with physician-diagnosed asthma. Conclusion This study identified 3 variants associated with FeNO, explaining 0.95% of the variance. Identification of functional SNPs and haplotypes in these regions might provide novel insight in the regulation of FeNO. This study highlights that both shared and distinct genetic factors affect FeNO and childhood asthma. PMID:24315451

  17. N*(1535) electroproduction at high Q2

    SciTech Connect

    G. Ramalho, M.T. Pena, K. Tsushima

    2012-04-01

    A covariant spectator quark model is applied to study the {gamma}N {yields} N*(1535) reaction in the large Q{sup 2} region. Starting from the relation between the nucleon and N*(1535) systems, the N*(1535) valence quark wave function is determined without the addition of any parameters. The model is then used to calculate the {gamma}N {yields} N*(1535) transition form factors. A very interesting, useful relation between the A{sub 1/2} and S{sub 1/2} helicity amplitudes for Q{sup 2} > GeV{sup 2}, is also derived.

  18. Q-switched laser prelase detection circuit

    NASA Technical Reports Server (NTRS)

    Lockard, George E.

    1991-01-01

    A compact electronic circuit was developed to detect prelasing in Q-swithed pulsed laser systems and once detected to shut down the laser before the next laser pulse occurs. The circuit is small, compact, and uses a minimum of components which makes it quite economical, thus readily lending itself to commercial applications. It can easily be incorporated into virtually any Q-switched laser system or reliability of a laser system by reducing a source of possible costly optical damage. The circuit operation and instrument requirements necessary to incorporate the circuit into a laser system are discussed.

  19. HYDRAULIC CONDUCTIVITY OF SALTSTONE FORMULATED USING 1Q11, 2Q11 AND 3Q11 TANK 50 SLURRY SAMPLES

    SciTech Connect

    Reigel, M.; Nichols, R.

    2012-06-27

    As part of the Saltstone formulation work requested by Waste Solidification Engineering (WSE), Savannah River National Laboratory (SRNL) was tasked with preparing Saltstone samples for fresh property analysis and hydraulic conductivity measurements using actual Tank 50 salt solution rather than simulated salt solution. Samples of low level waste salt solution collected from Tank 50H during the first, second, and third quarters of 2011 were used to formulate the Saltstone samples. The salt solution was mixed with premix (45 wt % slag, 45 wt % fly ash, and 10 wt % cement), in a ratio consistent with facility operating conditions during the quarter of interest. The fresh properties (gel, set, bleed) of each mix were evaluated and compared to the recommended acceptance criteria for the Saltstone Production Facility. ASTM D5084-03, Method C was used to measure the hydraulic conductivity of the Saltstone samples. The hydraulic conductivity of Saltstone samples prepared from 1Q11 and 2Q11 samples of Tank 50H is 4.2E-9 cm/sec and 2.6E-9 cm/sec, respectively. Two additional 2Q11 and one 3Q11 sample were not successfully tested due to the inability to achieve stable readings during saturation and testing. The hydraulic conductivity of the samples made from Tank 50H salt solution compare well to samples prepared with simulated salt solution and cured under similar conditions (1.4E-9 - 4.9E-8 cm/sec).

  20. Liquid Crystal Devices.

    ERIC Educational Resources Information Center

    Bradshaw, Madeline J.

    1983-01-01

    The nature of liquid crystals and several important liquid crystal devices are described. Ideas for practical experiments to illustrate the properties of liquid crystals and their operation in devices are also described. (Author/JN)

  1. External incontinence devices

    MedlinePlus

    ... of products that are available in your area. URINARY INCONTINENCE DEVICES Urine collection devices are mainly used by ... urinary system References Payne CK. Conservative management of urinary incontinence: Behavioral and pelvic floor therapy, urethral and pelvic ...

  2. Medical device error.

    PubMed

    Goodman, Gerald R

    2002-12-01

    This article discusses principal concepts for the analysis, classification, and reporting of problems involving medical device technology. We define a medical device in regulatory terminology and define and discuss concepts and terminology used to distinguish the causes and sources of medical device problems. Database classification systems for medical device failure tracking are presented, as are sources of information on medical device failures. The importance of near-accident reporting is discussed to alert users that reported medical device errors are typically limited to those that have caused an injury or death. This can represent only a fraction of the true number of device problems. This article concludes with a summary of the most frequently reported medical device failures by technology type, clinical application, and clinical setting. PMID:12400632

  3. Pancharatnam-Berry phase optical elements for generation and control of complex light: generalized superelliptical q-plates

    NASA Astrophysics Data System (ADS)

    Piccirillo, Bruno; Kumar, Vijay; Marrucci, Lorenzo; Santamato, E.

    2015-03-01

    We present newly conceived liquid-crystal-based retardation waveplates in which the optic axis distribution has a "superelliptically" symmetric azimuthal structure with a topological charge q superimposed. Such devices, named superelliptical q-plates, act as polarization-to-spatial modes converters that can be used to produce optical beams having peculiar spiral spectra. These spectra reflect the topological charge of the optic axis distribution as well as the symmetry properties of the underlying superellipse. The peculiar capability of q-plates of producing optical modes entangled with respect to spin and orbital angular momentum is here extended to superelliptical q-plates in order to create more complex optical modes structurally inseparable with respect to polarization and spatial degrees of freedom. Such superelliptical modes can play a crucial role in studying polarization singularities or to develop polarization metrology.

  4. Pulse detecting device

    DOEpatents

    Riggan, W.C.

    1984-01-01

    A device for measuring particle flux comprises first and second photodiode detectors for receiving flux from a source and first and second outputs for producing first and second signals representing the flux incident to the detectors. The device is capable of reducing the first output signal by a portion of the second output signal, thereby enhancing the accuracy of the device. Devices in accordance with the invention may measure distinct components of flux from a single source or fluxes from several sources.

  5. GAS DISCHARGE DEVICES

    DOEpatents

    Arrol, W.J.; Jefferson, S.

    1957-08-27

    The construction of gas discharge devices where the object is to provide a gas discharge device having a high dark current and stabilized striking voltage is described. The inventors have discovered that the introduction of tritium gas into a discharge device with a subsequent electrical discharge in the device will deposit tritium on the inside of the chamber. The tritium acts to emit beta rays amd is an effective and non-hazardous way of improving the abovementioned discharge tube characteristics

  6. q-Extension of the Euler formula and trigonometric functions

    NASA Astrophysics Data System (ADS)

    Kim, T.

    2007-09-01

    In this paper, we introduce a Daehee constant, the so-called q-extension of the Napier constant, and consider the Daehee formula associated with the q-extensions of trigonometric functions. That is, we derive the q-extensions of sine and cosine functions from our Daehee formula. Finally, we present the q-calculus related to the q-extensions of sine and cosine functions.

  7. Flexible thermal device

    NASA Technical Reports Server (NTRS)

    Wallace, S. D.; Elliott, D. H.

    1972-01-01

    Fabrication of expansion joint, vibration isolator device with sufficient cross sectional area for high thermal conductivity is discussed. Device consists of multiple layers of metal foil which may be designed to meet specific applications. Thermodynamic properties of the device and illustration of construction are provided.

  8. Amorphous silicon photovoltaic devices

    SciTech Connect

    Carlson, David E.; Lin, Guang H.; Ganguly, Gautam

    2004-08-31

    This invention is a photovoltaic device comprising an intrinsic or i-layer of amorphous silicon and where the photovoltaic device is more efficient at converting light energy to electric energy at high operating temperatures than at low operating temperatures. The photovoltaic devices of this invention are suitable for use in high temperature operating environments.

  9. Photovoltaic device and method

    DOEpatents

    Cleereman, Robert J; Lesniak, Michael J; Keenihan, James R; Langmaid, Joe A; Gaston, Ryan; Eurich, Gerald K; Boven, Michelle L

    2015-01-27

    The present invention is premised upon an improved photovoltaic device ("PVD") and method of use, more particularly to an improved photovoltaic device with an integral locator and electrical terminal mechanism for transferring current to or from the improved photovoltaic device and the use as a system.

  10. Organic photosensitive devices

    DOEpatents

    Rand, Barry P; Forrest, Stephen R

    2013-11-26

    The present invention generally relates to organic photosensitive optoelectronic devices. More specifically, it is directed to organic photosensitive optoelectronic devices having a photoactive organic region containing encapsulated nanoparticles that exhibit plasmon resonances. An enhancement of the incident optical field is achieved via surface plasmon polariton resonances. This enhancement increases the absorption of incident light, leading to a more efficient device.

  11. Photovoltaic device and method

    SciTech Connect

    Cleereman, Robert; Lesniak, Michael J.; Keenihan, James R.; Langmaid, Joe A.; Gaston, Ryan; Eurich, Gerald K.; Boven, Michelle L.

    2015-11-24

    The present invention is premised upon an improved photovoltaic device ("PVD") and method of use, more particularly to an improved photovoltaic device with an integral locator and electrical terminal mechanism for transferring current to or from the improved photovoltaic device and the use as a system.

  12. Articulating feedstock delivery device

    DOEpatents

    Jordan, Kevin

    2013-11-05

    A fully articulable feedstock delivery device that is designed to operate at pressure and temperature extremes. The device incorporates an articulating ball assembly which allows for more accurate delivery of the feedstock to a target location. The device is suitable for a variety of applications including, but not limited to, delivery of feedstock to a high-pressure reaction chamber or process zone.

  13. New multi-level codes over GF(q)

    NASA Technical Reports Server (NTRS)

    Wu, Jiantian; Costello, Daniel J., Jr.

    1990-01-01

    Set partitioning to multi-dimensional signal spaces over GF(q), particularly GF sup q-1(q) and GF sup q (q), and show how to construct both multi-level block codes and multi-level trellis codes over GF(q). Two classes of multi-level (n, k, d) block codes over GF(q) with block length n, number of information symbols k, and minimum distance d sub min greater than or = d, are presented. These two classes of codes use Reed-Solomon codes as component codes. They can be easily decoded as block length q-1 Reed-Solomon codes or block length q or q + 1 extended Reed-Solomon codes using multi-stage decoding. Many of these codes have larger distances than comparable q-ary block codes, as component codes. Low rate q-ary convolutional codes, work error correcting convolutional codes, and binary-to-q-ary convolutional codes can also be used to construct multi-level trellis codes over GF(q) or binary-to-q-ary trellis codes, some of which have better performance than the above block codes. All of the new codes have simple decoding algorithms based on hard decision multi-stage decoding.

  14. Paratesticular leiomyoma with a der(14)t(12;14)(q15;q24).

    PubMed

    Gorunova, Ludmila; Bjerkehagen, Bodil; Heim, Sverre

    2011-08-01

    While uterine leiomyomas are among the most common and best cytogenetically characterized solid tumors, leiomyomas at other sites are rare. Only two karyotypically abnormal leiomyomas in males have been reported to date, both of them with unspecific chromosome aberrations. We recently analyzed by G-banding a paratesticular leiomyoma, a tumor type not cytogenetically examined before, and found the pseudodiploid karyotype 46,XY,der(5)t(5;14)(q31;q24),der(14)t(12;14)(q15;q24). The leiomyoma cells demonstrated strong immunohistochemical nuclear expression of the HMGA2 protein, supporting a role of HMGA2 as the target gene in 12q14∼15 rearrangements. In uterine leiomyomas, the t(12;14)(q15;q24) is the most frequent translocation leading to overexpression of HMGA2, therefore it seems that a common pathogenetic pathway exists for benign smooth muscle tumors of both the female and male reproductive organs. The finding of this abnormality may help identify a scrotal tumor of uncertain biologic potential but with smooth muscle differentiation as benign. PMID:21962898

  15. A family with an inverted tandem duplication 5q22.1q23.2.

    PubMed

    Schmidt, T; Bartels, I; Liehr, T; Burfeind, P; Zoll, B; Shoukier, M

    2013-01-01

    Here, we report a 3-year-old boy with short stature, developmental delay and mild facial dysmorphic signs. Karyotype analysis and array-CGH revealed a pure duplication 5q22.1q23.2 with a length of 14.25 Mb. As demonstrated by multicolor-fluorescence in situ hybridization, the duplicated segment was orientated in an inverted tandem manner. One of the 2 older half-brothers of the index patient was intellectually disabled and showed short stature as well. The mother of the siblings was only 149 cm in height. The affected half-brother as well as the mother of the siblings were tested positive for the same duplication. Duplications of the long arm of chromosome 5 are rare. There are 16 reported cases of different 5q segments with a pure duplication and no additional chromosomal imbalance. In order to refine the 5q-duplication phenotype, reported cases were recently classified in 3 groups on the basis of clinical findings and the involved chromosome segments. However, our case does not fit in any of these groups but is placed in the interjacent chromosomal area between 2 of these groups. Overall, this is the second reported family with a duplication of 5q22.1q23.2 and both families share phenotypic features like short stature, facial dysmorphic signs and speech delay. The reported family provides further information for delineating phenotype-genotype correlations of pure duplications of the 5q region. PMID:23051634

  16. Extended q -Gaussian and q -exponential distributions from gamma random variables

    NASA Astrophysics Data System (ADS)

    Budini, Adrián A.

    2015-05-01

    The family of q -Gaussian and q -exponential probability densities fit the statistical behavior of diverse complex self-similar nonequilibrium systems. These distributions, independently of the underlying dynamics, can rigorously be obtained by maximizing Tsallis "nonextensive" entropy under appropriate constraints, as well as from superstatistical models. In this paper we provide an alternative and complementary scheme for deriving these objects. We show that q -Gaussian and q -exponential random variables can always be expressed as a function of two statistically independent gamma random variables with the same scale parameter. Their shape index determines the complexity q parameter. This result also allows us to define an extended family of asymmetric q -Gaussian and modified q -exponential densities, which reduce to the standard ones when the shape parameters are the same. Furthermore, we demonstrate that a simple change of variables always allows relating any of these distributions with a beta stochastic variable. The extended distributions are applied in the statistical description of different complex dynamics such as log-return signals in financial markets and motion of point defects in a fluid flow.

  17. High Q silicon carbide microdisk resonator

    SciTech Connect

    Lu, Xiyuan; Lee, Jonathan Y.; Feng, Philip X.-L.; Lin, Qiang

    2014-05-05

    We demonstrate a silicon carbide (SiC) microdisk resonator with optical Q up to 5.12 × 10{sup 4}. The high optical quality, together with the diversity of whispering-gallery modes and the tunability of external coupling, renders SiC microdisk a promising platform for integrated quantum photonics applications.

  18. Deletion 5q35.3

    SciTech Connect

    Stratton, R.F.; Tedrowe, N.A.; Tolworthy, J.A.; Patterson, R.M.; Ryan, S.G.; Young, R.S.

    1994-06-01

    The authors report on a 15-month-old boy with a de novo deletion of the terminal band of 5q, macrocephaly, mild retrognathia, anteverted nares with low flat nasal bridge, telecanthus, minor earlobe anomalies, bellshaped chest, diastasis recti, short fingers, and mild developmental delay.

  19. Q-Method Extended Kalman Filter

    NASA Technical Reports Server (NTRS)

    Zanetti, Renato; Ainscough, Thomas; Christian, John; Spanos, Pol D.

    2012-01-01

    A new algorithm is proposed that smoothly integrates non-linear estimation of the attitude quaternion using Davenport s q-method and estimation of non-attitude states through an extended Kalman filter. The new method is compared to a similar existing algorithm showing its similarities and differences. The validity of the proposed approach is confirmed through numerical simulations.

  20. The Q-Way of Doing Analysis

    ERIC Educational Resources Information Center

    Oldenburg, Reinhard

    2005-01-01

    The subject of q-calculus is a rich source of learning activities that address concept formation, exploration, variation, rich training and proof. This paper is a survey of the subject that shows how high school students using a computer algebra system can explore the field and prove some results. (Contains 7 figures.)

  1. Graphene Q-switched, tunable fiber laser

    NASA Astrophysics Data System (ADS)

    Popa, D.; Sun, Z.; Hasan, T.; Torrisi, F.; Wang, F.; Ferrari, A. C.

    2011-02-01

    We demonstrate a wideband-tunable Q-switched fiber laser exploiting a graphene saturable absorber. We get ˜2 μs pulses, tunable between 1522 and 1555 nm with up to ˜40 nJ energy. This is a simple and low-cost light source for metrology, environmental sensing, and biomedical diagnostics.

  2. A Q-Analysis of Television Programmes.

    ERIC Educational Resources Information Center

    Johnson, J. H.

    1978-01-01

    Documents an experiment in the application of R. H. Atkin's methodology of Q-analysis in the field of television which demonstrates how it may be applied to program schedules. A theoretical discussion illustrates the relationships between the program-time interval backcloth and the viewing patterns it can support. (Author/VT)

  3. Q-Switching in a Neodymium Laser

    ERIC Educational Resources Information Center

    Holgado, Warein; Sola, Inigo J.; Jarque, Enrique Conejero; Jarabo, Sebastian; Roso, Luis

    2012-01-01

    We present a laboratory experiment for advanced undergraduate or graduate laser-related classes to study the performance of a neodymium laser. In the experiment, the student has to build the neodymium laser using an open cavity. After that, the cavity losses are modulated with an optical chopper located inside, so the Q-switching regime is…

  4. Cochran Q test with Turbo BASIC.

    PubMed

    Seuc, A H

    1995-01-01

    A microcomputer program written in Turbo BASIC for the sequential application of the Cochran Q test is given. A clinical application where the test is used in order to explore the structure of the agreement between observers is also presented. A program listing is available on request. PMID:7743778

  5. Partial trisomy 14q and monosomy 20q due to an unbalanced familial translocation

    SciTech Connect

    Menasse-Palmer, L; Leo, J.; Cannizaro, L.

    1994-09-01

    Partial trisomy of distal 14q and monosomy of 20q are rare. There have been several reports of a partial distal trisomy 14q with characteristic clinical findings, including hypogonadism and a conotruncal cardiac anomaly. There is no deletion distal 20q syndrome. We have recently examined a newborn with this unique duplication/deletion syndrome. Case report: J.S. was the 2980 gm product of a term uneventful pregnancy delivered to a 24-year-old gravida 2, para 1001 mother. The newborn exam revealed a dysmorphic newborn male with a sloping forehead, bitemporal narrowing, glabellar furrowing and micrognathia. A systolic murmur was audible. The genital abnormalities were micropenis, hypospadias with chordee and bifid scrotum with prominent raphe, and gonads were palpable. A CAT scan of the head revealed grade I IVH. An echocardiogram showed a VSD, ASD and an AP window. A sonogram of the liver showed absence of the gallbladder. Chromosome analysis revealed an abnormal male karyotype containing a derivative 20, subsequently shown to be inherited as a result of malsegregation of a paternal translocation: 46,XY,-20,+der(20)t(14;20)(q32.1;q13.3)pat. The infant fed poorly and required tube feedings and was treated for congestive heart failure with Digoxin, Lasix and oxygen. A decreased cortisol level and cholestasis were noted. The infant died after a cardiopulmonary arrest at one month of age. No post-mortem was obtained. Clinical cytogenetic correlation (conotruncal abnormality and hypogonadism) with partial duplication of distal 14q was positive. This case helps to further delineate duplication 14q and a syndrome due to partial deletion 20q.

  6. Biomechanics of interspinous devices.

    PubMed

    Parchi, Paolo D; Evangelisti, Gisberto; Vertuccio, Antonella; Piolanti, Nicola; Andreani, Lorenzo; Cervi, Valentina; Giannetti, Christian; Calvosa, Giuseppe; Lisanti, Michele

    2014-01-01

    A number of interspinous devices (ISD) have been introduced in the lumbar spine implant market. Unfortunately, the use of these devices often is not associated with real comprehension of their biomechanical role. The aim of this paper is to review the biomechanical studies about interspinous devices available in the literature to allow the reader a better comprehension of the effects of these devices on the treated segment and on the adjacent segments of the spine. For this reason, our analysis will be limited to the interspinous devices that have biomechanical studies published in the literature. PMID:25114923

  7. Biomechanics of Interspinous Devices

    PubMed Central

    Parchi, Paolo D.; Evangelisti, Gisberto; Vertuccio, Antonella; Piolanti, Nicola; Andreani, Lorenzo; Cervi, Valentina; Giannetti, Christian; Calvosa, Giuseppe; Lisanti, Michele

    2014-01-01

    A number of interspinous devices (ISD) have been introduced in the lumbar spine implant market. Unfortunately, the use of these devices often is not associated with real comprehension of their biomechanical role. The aim of this paper is to review the biomechanical studies about interspinous devices available in the literature to allow the reader a better comprehension of the effects of these devices on the treated segment and on the adjacent segments of the spine. For this reason, our analysis will be limited to the interspinous devices that have biomechanical studies published in the literature. PMID:25114923

  8. Solid state devices

    NASA Technical Reports Server (NTRS)

    1991-01-01

    The Solid State Device research program is directed toward developing innovative devices for space remote and in-situ sensing, and for data processing. Innovative devices can result from the standard structures in innovative materials such as low and high temperature superconductors, strained layer superlattices, or diamond films. Innovative devices can also result from innovative structures achieved using electron tunneling or nanolithography in standard materials. A final step is to use both innovative structures and innovative materials. A new area of emphasis is the miniaturization of sensors and instruments molded by using the techniques of electronic device fabrication to micromachine silicon into micromechanical and electromechanical sensors and actuators.

  9. Portable data collection device

    DOEpatents

    French, Patrick D.

    1996-01-01

    The present invention provides a portable data collection device that has a variety of sensors that are interchangeable with a variety of input ports in the device. The various sensors include a data identification feature that provides information to the device regarding the type of physical data produced by each sensor and therefore the type of sensor itself. The data identification feature enables the device to locate the input port where the sensor is connected and self adjust when a sensor is removed or replaced. The device is able to collect physical data, whether or not a function of a time.

  10. Thermionic deposition devices (survey)

    SciTech Connect

    Saenko, V.A.

    1985-11-01

    Various devices for the deposition of thin films and coatings from a plasma of solid-phase-material vapor are surveyed. The devices operate by vaporization and ionization of the working material in a vacuum. The classification, parameters, designs and development trends of thermionic devices (plasma vaporizers) are examined. Their characteristics and areas of application in modern high-energy plasma technology are described. The relative simplicity of the design and operation of the devices should allow them to be widely used not only in the laboratory but also in industry. The first manufactured units with thermionic devices and some of the properties of the films they produce are described.

  11. Active cleaning technique device

    NASA Technical Reports Server (NTRS)

    Shannon, R. L.; Gillette, R. B.

    1973-01-01

    The objective of this program was to develop a laboratory demonstration model of an active cleaning technique (ACT) device. The principle of this device is based primarily on the technique for removing contaminants from optical surfaces. This active cleaning technique involves exposing contaminated surfaces to a plasma containing atomic oxygen or combinations of other reactive gases. The ACT device laboratory demonstration model incorporates, in addition to plasma cleaning, the means to operate the device as an ion source for sputtering experiments. The overall ACT device includes a plasma generation tube, an ion accelerator, a gas supply system, a RF power supply and a high voltage dc power supply.

  12. Unitary lens semiconductor device

    DOEpatents

    Lear, K.L.

    1997-05-27

    A unitary lens semiconductor device and method are disclosed. The unitary lens semiconductor device is provided with at least one semiconductor layer having a composition varying in the growth direction for unitarily forming one or more lenses in the semiconductor layer. Unitary lens semiconductor devices may be formed as light-processing devices such as microlenses, and as light-active devices such as light-emitting diodes, photodetectors, resonant-cavity light-emitting diodes, vertical-cavity surface-emitting lasers, and resonant cavity photodetectors. 9 figs.

  13. Unitary lens semiconductor device

    DOEpatents

    Lear, Kevin L.

    1997-01-01

    A unitary lens semiconductor device and method. The unitary lens semiconductor device is provided with at least one semiconductor layer having a composition varying in the growth direction for unitarily forming one or more lenses in the semiconductor layer. Unitary lens semiconductor devices may be formed as light-processing devices such as microlenses, and as light-active devices such as light-emitting diodes, photodetectors, resonant-cavity light-emitting diodes, vertical-cavity surface-emitting lasers, and resonant cavity photodetectors.

  14. Portable data collection device

    DOEpatents

    French, P.D.

    1996-06-11

    The present invention provides a portable data collection device that has a variety of sensors that are interchangeable with a variety of input ports in the device. The various sensors include a data identification feature that provides information to the device regarding the type of physical data produced by each sensor and therefore the type of sensor itself. The data identification feature enables the device to locate the input port where the sensor is connected and self adjust when a sensor is removed or replaced. The device is able to collect physical data, whether or not a function of a time. 7 figs.

  15. Superconductivity devices: Commercial use of space

    NASA Technical Reports Server (NTRS)

    Haertling, Gene; Hsi, Chi-Shiung; Mcintyre, Ladawn; Li, Guang

    1992-01-01

    The high T(sub c) superconducting ceramic materials, developed in 1987, are now being extensively investigated for a variety of engineering applications. These applications include such devices as conducting links, rotating and linear bearings, sensors, filters, switches, high Q cavities, magnets, and motors. Some of these devices take advantage of the material's ability to lose all electrical resistance at a critical temperature, T(sub c), while others make use of the repulsion forces generated between the magnetic field of a permanent magnet and a superconductor which is cooled below its T(sub c), Meissner effect. This report describes the work accomplished to date by: (1) reviewing the present state of the art in actuator technology, (2) evaluating processing and fabrication of high strain electrostrictive materials, and (3) testing these electrostrictive materials.

  16. Exploring Carbon Nanotubes for Nanoscale Devices

    NASA Technical Reports Server (NTRS)

    Han, Jie; Dai; Anantram; Jaffe; Saini, Subhash (Technical Monitor)

    1998-01-01

    Carbon nanotubes (CNTs) are shown to promise great opportunities in nanoelectronic devices and nanoelectromechanical systems (NEMS) because of their inherent nanoscale sizes, intrinsic electric conductivities, and seamless hexagonal network architectures. I present our collaborative work with Stanford on exploring CNTs for nanodevices in this talk. The electrical property measurements suggest that metallic tubes are quantum wires. Furthermore, two and three terminal CNT junctions have been observed experimentally. We have proposed and studied CNT-based molecular switches and logic devices for future digital electronics. We also have studied CNTs based NEMS inclusing gears, cantilevers, and scanning probe microscopy tips. We investigate both chemistry and physics based aspects of the CNT NEMS. Our results suggest that CNT have ideal stiffness, vibrational frequencies, Q-factors, geometry-dependent electric conductivities, and the highest chemical and mechanical stabilities for the NEMS. The use of CNT SPM tips for nanolithography is presented for demonstration of the advantages of the CNT NEMS.

  17. Molecular cloning and characterization of 3q21 breakpoints from leukemia-associated t(3;3)(q21;q26)

    SciTech Connect

    Gardiner, K.; Pekarsky, Y.; Zabarovsky, E.

    1994-09-01

    A variety of rearrangements of 3q21, including deletion, translocation with 3q26 and other chromosomes, and inversion of 3q21-3q26, have been associated with hematological malignancy. To begin characterization of the 3q21 breakpoint region, the der3q- and der3q+ chromosomes from 2 separate leukemia patients carrying t(3;3)(q21;q26) have been isolated in hybrid cell lines, and the der3q- chromosomes analyzed extensively. In both cases, the 3q26 breakpoints occur between the EAP and EVI1 genes without direct rearrangement of either gene. In 3q21, 2 NotI linking clones have been identified that are physically linked on a 50 kb NotI fragment that spans both 3q21 breakpoints. To characterize this region further, an 80 kb P1 clone containing both NotI clones has been isolated from the Dupont total human P1 library. The breakpoints have been localized within this clone to SacI fragments of 1 kb and 0.8 kb that are separated by 9 kb. This is preliminary evidence suggesting that the 3q21 leukemia breakpoints may be generally more clustered than those within 3q26. Rare restriction site mapping of the P1 clone shows a high density of sites and suggests a GC-rich and therefore potentially gene-rich region. Sequence analysis of the breakpoint fragments has so far yielded no homologies with known genes; however, preliminary analysis around the NotI site 35 kb centromeric to the breakpoints shows homology with several transcription factor genes. Isolation of all genes within the P1 clone is in progress.

  18. De novo direct duplication of chromosome segment 22q11.2-q13.1

    SciTech Connect

    Fujimoto, Atsuko; Lin, Ming S.

    1996-03-29

    Lindsay et al. [1995] reported a case of de novo duplication of the segment 22q11-q12. Molecular cytogenetics studies showed that the segment includes the regions responsible for the {open_quotes}cat eye,{close_quotes} DiGeorge, and velo-cardio-facial syndrome, and extends distal to the breakpoint cluster region. The phenotype was milder than that of complete trisomy 22 and der(22)t(11;22) (q23;q11) syndrome and was similar in type and severity to that of {open_quotes}cat eye{close_quotes} syndrome (CES). They suggested that trisomy of gene(s) responsible for the CES might have a predominant phenotypic effect over other genes present in the region duplicated in their patient. 3 refs., 2 figs.

  19. Detecting the lowest-energy structures of CAu16q(q=-1,0)

    NASA Astrophysics Data System (ADS)

    Fa, Wei; Yang, Aping

    2008-10-01

    Using scalar relativistic density-functional simulations, we have performed a detailed study of the structural and electronic properties of CAu16q(q=-1,0). We have discovered that the most stable configurations of both the neutral and anionic C-doped gold clusters are not endohedral structures but distorted close-flat cages, in which the carbon atom prefers forming covalent bonds with its four nearest-neighboring gold atoms. Despite the geometrical similarity between the CAu 4 and SiAu 4, the lowest-energy CAu16q(q=-1,0) show a square-pyramid local structure around the dopant carbon just like the cases of GeAu16- and SnAu16-, displaying different photoelectron spectroscopy with those of isomers with a dangling gold atom atop carbon.

  20. On a (β, q)-generalized Fisher information and inequalities involving q-Gaussian distributions

    NASA Astrophysics Data System (ADS)

    Bercher, J.-F.

    2012-06-01

    In the present paper, we would like to draw attention to a possible generalized Fisher information that fits well in the formalism of nonextensive thermostatistics. This generalized Fisher information is defined for densities on {R}n. Just as the maximum Rényi or Tsallis entropy subject to an elliptic moment constraint is a generalized q-Gaussian, we show that the minimization of the generalized Fisher information also leads a generalized q-Gaussian. This yields a generalized Cramér-Rao inequality. In addition, we show that the generalized Fisher information naturally pops up in a simple inequality that links the generalized entropies, the generalized Fisher information, and an elliptic moment. Finally, we give an extended Stam inequality. In this series of results, the extremal functions are the generalized q-Gaussians. Thus, these results complement the classical characterization of the generalized q-Gaussian and introduce a generalized Fisher information as a new information measure in nonextensive thermostatistics.

  1. Absorption spectra of Q 0000-263 and Q 1442+101

    NASA Technical Reports Server (NTRS)

    Frye, B. L.; Bechtold, J.; Moustakas, L. A.; Dobrzycki, A.

    1993-01-01

    Studying the Lyman-alpha forest allows us to trace the cosmological distribution of matter through time, and may reveal insights into important questions such as the onset of galaxy formation. An equation for determining the number of Lyman-alpha absorption lines per redshift per rest equivalent in the Lyman-alpha forest is given. For a nonevolving population of clouds gamma = 1 for q(sub 0) = 0, and gamma = 0.5 for q(sub 0) = 0.5. A detailed study of the Lyman-alpha forests of Q 1442+101 at z(sub em) = 3.54 and Q 0000-263 at z(sub em) = 4.11.

  2. DEVICE CONTROLLER, CAMERA CONTROL

    Energy Science and Technology Software Center (ESTSC)

    1998-07-20

    This is a C++ application that is the server for the cameral control system. Devserv drives serial devices, such as cameras and videoswitchers used in a videoconference, upon request from a client such as the camxfgbfbx ccint program. cc Deverv listens on UPD ports for clients to make network contractions. After a client connects and sends a request to control a device (such as to pan,tilt, or zooma camera or do picture-in-picture with a videoswitcher),more » devserv formats the request into an RS232 message appropriate for the device and sends this message over the serial port to which the device is connected. Devserv then reads the reply from the device from the serial port to which the device is connected. Devserv then reads the reply from the device from the serial port and then formats and sends via multicast a status message. In addition, devserv periodically multicasts status or description messages so that all clients connected to the multicast channel know what devices are supported and their ranges of motion and the current position. The software design employs a class hierarchy such that an abstract base class for devices can be subclassed into classes for various device categories(e.g. sonyevid30, cononvco4, panasonicwjmx50, etc.). which are further subclassed into classes for various device categories. The devices currently supported are the Sony evi-D30, Canon, VCC1, Canon VCC3, and Canon VCC4 cameras and the Panasonic WJ-MX50 videoswitcher. However, developers can extend the class hierarchy to support other devices.« less

  3. DEVICE CONTROLLER, CAMERA CONTROL

    SciTech Connect

    Perry, Marcia

    1998-07-20

    This is a C++ application that is the server for the cameral control system. Devserv drives serial devices, such as cameras and videoswitchers used in a videoconference, upon request from a client such as the camxfgbfbx ccint program. cc Deverv listens on UPD ports for clients to make network contractions. After a client connects and sends a request to control a device (such as to pan,tilt, or zooma camera or do picture-in-picture with a videoswitcher), devserv formats the request into an RS232 message appropriate for the device and sends this message over the serial port to which the device is connected. Devserv then reads the reply from the device from the serial port to which the device is connected. Devserv then reads the reply from the device from the serial port and then formats and sends via multicast a status message. In addition, devserv periodically multicasts status or description messages so that all clients connected to the multicast channel know what devices are supported and their ranges of motion and the current position. The software design employs a class hierarchy such that an abstract base class for devices can be subclassed into classes for various device categories(e.g. sonyevid30, cononvco4, panasonicwjmx50, etc.). which are further subclassed into classes for various device categories. The devices currently supported are the Sony evi-D30, Canon, VCC1, Canon VCC3, and Canon VCC4 cameras and the Panasonic WJ-MX50 videoswitcher. However, developers can extend the class hierarchy to support other devices.

  4. q-bosons, Toda lattice, Pieri rules and Baxter q-operator

    NASA Astrophysics Data System (ADS)

    Duval, Antoine; Pasquier, Vincent

    2016-04-01

    We use the Pieri rules to recover the q-boson model and show it is equivalent to a discretized version of the relativistic Toda chain. We identify its semi infinite transfer matrix and the corresponding Baxter Q-matrix with half vertex operators related by an ω-duality transformation. We observe that the scalar product of two higher spin XXZ wave functions can be expressed with a Gaudin determinant. In honour of Rodney Baxter’s 75th birthday.

  5. The prostatic acid phosphatase (ACPP) gene is localized to human chromosome 3q21-q23

    SciTech Connect

    Li, S.S.L.; Sharief, F.S. )

    1993-09-01

    Human prostatic acid phosphatase (ACPP) has been used as a diagnostic marker for prostate cancer. It is synthesized under androgen regulation and secreted by the epithelial cells of the prostate gland. The authors have confirmed the previous assignment of the ACPP gene to chromosome 3 by probing a panel of 25 human-Chinese hamster somatic cell hybrids, and they have further localized the ACPP gene to chromosome 3q21-q23 by fluorescence in situ hybridization. 10 refs., 1 fig.

  6. Genetic bases and clinical manifestations of coenzyme Q10 (CoQ 10) deficiency.

    PubMed

    Desbats, Maria Andrea; Lunardi, Giada; Doimo, Mara; Trevisson, Eva; Salviati, Leonardo

    2015-01-01

    Coenzyme Q(10) is a remarkable lipid involved in many cellular processes such as energy production through the mitochondrial respiratory chain (RC), beta-oxidation of fatty acids, and pyrimidine biosynthesis, but it is also one of the main cellular antioxidants. Its biosynthesis is still incompletely characterized and requires at least 15 genes. Mutations in eight of them (PDSS1, PDSS2, COQ2, COQ4, COQ6, ADCK3, ADCK4, and COQ9) cause primary CoQ(10) deficiency, a heterogeneous group of disorders with variable age of onset (from birth to the seventh decade) and associated clinical phenotypes, ranging from a fatal multisystem disease to isolated steroid resistant nephrotic syndrome (SRNS) or isolated central nervous system disease. The pathogenesis is complex and related to the different functions of CoQ(10). It involves defective ATP production and oxidative stress, but also an impairment of pyrimidine biosynthesis and increased apoptosis. CoQ(10) deficiency can also be observed in patients with defects unrelated to CoQ(10) biosynthesis, such as RC defects, multiple acyl-CoA dehydrogenase deficiency, and ataxia and oculomotor apraxia.Patients with both primary and secondary deficiencies benefit from high-dose oral supplementation with CoQ(10). In primary forms treatment can stop the progression of both SRNS and encephalopathy, hence the critical importance of a prompt diagnosis. Treatment may be beneficial also for secondary forms, although with less striking results.In this review we will focus on CoQ(10) biosynthesis in humans, on the genetic defects and the specific clinical phenotypes associated with CoQ(10) deficiency, and on the diagnostic strategies for these conditions. PMID:25091424

  7. Ectrodactyly and proximal/intermediate interstitial deletion 7q

    SciTech Connect

    McElveen, C.; Carvajal, M.V.; Moscatello, D.

    1995-03-13

    We report on an individual with severe mental retardation, seizures, microcephaly, unusual face, scoliosis, and cleft feet and cleft right hand. The chromosomal study showed a proximal interstitial deletion 7q (q11.23q22). From our review of the literature, 11 patients have been reported with ectrodactyly (split hand/split foot malformation) and proximal/intermediate interstitial deletions or rearrangements of 7q. The critical segment for ectrodactyly seems to be located between 7q21.2 and 7q22.1. This malformation is present in 41% of the patients whose deletion involves the critical segment. 37 refs., 3 figs., 1 tab.

  8. Delineation of 2q32q35 deletion phenotypes: two apparent "proximal" and "distal" syndromes.

    PubMed

    Mc Cormack, Adrian; Taylor, Juliet; Gregersen, Nerine; George, Alice M; Love, Donald R

    2013-01-01

    We report on three patients with interstitial deletions of the long arm of chromosome 2 involving bands 2q32.1-q35. They presented with wide-ranging phenotypic variation including facial dysmorphisms, cleft palate, learning difficulties, behavioural issues and severe heart defects. Microarray analysis confirmed an 8.6 Mb deletion in patients 1 and 2 and a 24.7 Mb deletion in patient 3. We discuss the genes involved in the deleted regions including MYO1B, GLS, FRZB, SATB2, and CPS1 and compare the phenotype with those reported in the literature. Taken together, these data suggest that there is a spectrum of disease severity such that patients with deletions encompassing the region of 2q32.1q32.2, which includes the FRZB gene, show an apparently milder phenotype compared to those that lie further distal in 2q32.3q35 that encompasses the SATB2 gene. PMID:23840981

  9. Association of allelic losses on human chromosomal arms 11Q and 16Q in sporadic breast cancer.

    PubMed

    Schmutzler, R K; Fimmers, R; Bierhoff, E; Lohmar, B; Homann, A; Speiser, P; Kubista, E; Jaeger, K; Krebs, D; Zeillinger, R; Wiestler, O D; Von Deimling, A

    1996-08-22

    Breast-carcinoma development presumably results from multiple mutational events in tumor-associated genes. Certain results indicate that some tumor-suppressor genes may combine their pathogenetic potential to synergistically promote tumor growth. In an effort to identify such mechanisms in breast tumors, a series of 77 (group I) paired blood tumor samples from patients with sporadic mammary carcinomas was analyzed for loss of heterozygosity with 15 polymorphic markers on the chromosomal arms 7q, 11q, 13q, 16q, 17p and 17q. A significant association was observed for the combination of allelic losses on chromosomes 11q and 16q. In order to confirm these findings, we studied a second independent series of 189 breast-tumor patients (group 2) with comparable histopathological tumor stages. Group 2 was examined for the same genetic alterations using the identical set of polymorphic markers. The data from this group confirmed the detected association of loss of heterozygosity on chromosomes 11q and 16q and indicate the cooperation of putative tumor-suppressor genes on the chromosomal arms 11q and 16q in a sub-set of breast carcinomas. The regions involved harbor the candidate genes ATM (mutated in ataxiatelangiectasia) on chromosome 11q23 and UVO (uvomorulin, cadherin E) and BBCI (breast basic conserved I) on chromosome 16q22-q24. PMID:8797873

  10. Neurological aspects of del(1q) syndrome.

    PubMed

    Murayama, K; Greenwood, R S; Rao, K W; Aylsworth, A S

    1991-09-15

    We have studied three children with de novo terminal deletion of the long arm of chromosome 1 (46,XX,del(1)(q43)). They all have minor anomalies and neurological signs (severe psychomotor developmental delay, generalized hypotonia, and seizures) that have been described previously. In addition, all of these three patients have autistic-like behavior. They avoid eye contact, show no interest in people, express little emotion, and repeat stereotypic movements such as head nodding and purposeless finger manipulation. They also spend excessive time in making unusual sounds consisting of a high-pitched shrill cry with little intonation in infancy and a harsh, strained, and glottal stridency in later life. They make no labial, lingual, or nasal sounds. We suggest that these observations may be unique clinical manifestations of certain terminal 1q deletions. PMID:1746617

  11. The long Q-T syndromes.

    PubMed

    Gordon, N

    1994-01-01

    Loss of consciousness in childhood may be due to cardiovascular causes, and the Long Q-T syndromes can present with seizures. The Romano-Ward syndrome is of autosomal dominant inheritance, and the Jervell and Lange-Nielson syndrome, with associated deafness, of autosomal recessive inheritance. The diagnosis is often delayed, but a careful history can avoid this. The syndromes can appear to be due to an imbalance in the sympathetic nerve to the ventricular myocardium, and precipitating causes such as stress suggest a CNS influence on this. The electrocardiogram can confirm the prolonged Q-T interval, but this is not always present, at least without an exercise test. Treatment with beta-blockers is often successful. If a wrong diagnosis of epilepsy is made a chance may be missed of avoiding sudden death, quite apart from all the medical, and social consequences that can result from such a diagnosis. PMID:8048706

  12. Millimeter wave I-Q standoff biosensor

    NASA Astrophysics Data System (ADS)

    Liao, Shaolin; Bakhtiari, Sasan; Elmer, Thomas; Raptis, Apostolos C.; Mikhelson, Ilya V.; Sahakian, Alan V.

    2012-06-01

    A continuous wave (CW) 94-GHz millimeter wave (mmW) standoff biosensor has been developed for remote biometric sensing applications. The sensor measures the demodulated in-phase (I) and quadrature-phase (Q) components of the received reflected mmW signal from a subject. Both amplitude and phase of the reflected signal are obtained from downconverted I and Q channels from the quadrature mixer. The mmW sensor can faithfully monitor human vital signs (heartbeat and respiration) at relatively long standoff distances. Principle Component Analysis (PCA) is used to extract the heartbeat, the respiration and the body motion signals. The approach allows one to deduce information about amplitude and beat-to-beat rate of the respiration and the heartbeat. Experimental results collected from a subject were analyzed and compared to the signal obtained with a three-electrode ECG monitoring instrument.

  13. Cosmic (p,q,r) strings

    SciTech Connect

    Jackson, Mark G.

    2007-04-15

    The spectrum of (p,q) bound states of F- and D-strings has a distinctive square-root tension formula that is hoped to be a hallmark of fundamental cosmic strings. We point out that the Bogomol'nyi-Prasad-Sommerfield (BPS) bound for vortices in N=2 supersymmetric Abelian-Higgs models also takes the square-root form. In contrast to string theory, the most general supersymmetric field theoretic model allows for (p,q,r) strings, with three classes of strings rather than two. Unfortunately, we find that there do not exist BPS solutions except in the trivial case. The issue of whether there exist non-BPS solutions which may closely resemble the square-root form is left as an open question.

  14. [Q fever, a potential biowarfare agent].

    PubMed

    Bossi, Philippe; Guihot, Amélie; Bricaire, François

    2003-10-18

    SEVERAL POSSIBLE METHODS OF TRANSFUSION: Q fever is a zoonosis due to Coxiella burnetii. Its interest as a potential biowarfare agent is in its possible transmission by inhalation of sprayed particles. This form of transmission would probably be used: the inhalation of 1 to 10 bacteria could provoke the development of an infection in humans. Another possible method of transmission in the context of a terrorist act would be the intentional introduction of the bacteria into foodstuff. A DISABLING WEAPON: However, C. burnetii has never been used as a biological weapon. The probability that this germ could be used is very low: indeed, the incubation of Q fever is very long, and the majority of the infections is asymptomatic and mortality is low. In fact C. burnetii would more likely be used as a disabling weapon. PMID:14576588

  15. Selective excitation of high-Q resonant modes in a bottle/quasi-cylindrical microresonator

    NASA Astrophysics Data System (ADS)

    Dong, Yongchao; Jin, Xueying; Wang, Keyi

    2016-08-01

    We fabricate a bottle/quasi-cylindrical microresonator by using a fusion splicer. This method does not require a real-time control of the translation stages and can easily fabricate a resonator with expected size and shape. Selective excitation of whispering gallery modes (WGMs) in the resonator is realized with a fiber taper coupled at various positions of the resonator along the bottle axis. Most importantly, we obtain a clean and regular spectrum with very high quality factor (Q) modes up to 3.1×107 in the quasi-cylindrical region of the resonator. Moreover, we package the coupling system into a whole device that can be moved freely. The vibration performance tests of the packaged device show that the coupling system with the taper coupled at the quasi-cylindrical region has a remarkable anti-vibration ability. The portability and robustness of the device make it attractive in practical applications.

  16. Degradation of AF1Q by chaperone-mediated autophagy

    SciTech Connect

    Li, Peng; Ji, Min; Lu, Fei; Zhang, Jingru; Li, Huanjie; Cui, Taixing; Li Wang, Xing; Tang, Dongqi; Ji, Chunyan

    2014-09-10

    AF1Q, a mixed lineage leukemia gene fusion partner, is identified as a poor prognostic biomarker for pediatric acute myeloid leukemia (AML), adult AML with normal cytogenetic and adult myelodysplastic syndrome. AF1Q is highly regulated during hematopoietic progenitor differentiation and development but its regulatory mechanism has not been defined clearly. In the present study, we used pharmacological and genetic approaches to influence chaperone-mediated autophagy (CMA) and explored the degradation mechanism of AF1Q. Pharmacological inhibitors of lysosomal degradation, such as chloroquine, increased AF1Q levels, whereas activators of CMA, including 6-aminonicotinamide and nutrient starvation, decreased AF1Q levels. AF1Q interacts with HSPA8 and LAMP-2A, which are core components of the CMA machinery. Knockdown of HSPA8 or LAMP-2A increased AF1Q protein levels, whereas overexpression showed the opposite effect. Using an amino acid deletion AF1Q mutation plasmid, we identified that AF1Q had a KFERQ-like motif which was recognized by HSPA8 for CMA-dependent proteolysis. In conclusion, we demonstrate for the first time that AF1Q can be degraded in lysosomes by CMA. - Highlights: • Chaperone-mediated autophagy (CMA) is involved in the degradation of AF1Q. • Macroautophagy does not contribute to the AF1Q degradation. • AF1Q has a KFERQ-like motif that is recognized by CMA core components.

  17. Decreased Coenzyme Q10 Levels in Multiple System Atrophy Cerebellum.

    PubMed

    Barca, Emanuele; Kleiner, Giulio; Tang, Guomei; Ziosi, Marcello; Tadesse, Saba; Masliah, Eliezer; Louis, Elan D; Faust, Phyllis; Kang, Un J; Torres, Jose; Cortes, Etty P; Vonsattel, Jean-Paul G; Kuo, Sheng-Han; Quinzii, Catarina M

    2016-07-01

    In familial and sporadic multiple system atrophy (MSA) patients, deficiency of coenzyme Q10 (CoQ10) has been associated with mutations in COQ2, which encodes the second enzyme in the CoQ10 biosynthetic pathway. Cerebellar ataxia is the most common presentation of CoQ10 deficiency, suggesting that the cerebellum might be selectively vulnerable to low levels of CoQ10 To investigate whether CoQ10 deficiency represents a common feature in the brains of MSA patients independent of the presence of COQ2 mutations, we studied CoQ10 levels in postmortem brains of 12 MSA, 9 Parkinson disease (PD), 9 essential tremor (ET) patients, and 12 controls. We also assessed mitochondrial respiratory chain enzyme activities, oxidative stress, mitochondrial mass, and levels of enzymes involved in CoQ biosynthesis. Our studies revealed CoQ10 deficiency in MSA cerebellum, which was associated with impaired CoQ biosynthesis and increased oxidative stress in the absence of COQ2 mutations. The levels of CoQ10 in the cerebella of ET and PD patients were comparable or higher than in controls. These findings suggest that CoQ10 deficiency may contribute to the pathogenesis of MSA. Because no disease modifying therapies are currently available, increasing CoQ10 levels by supplementation or upregulation of its biosynthesis may represent a novel treatment strategy for MSA patients. PMID:27235405

  18. Sensor sentinel computing device

    DOEpatents

    Damico, Joseph P.

    2016-08-02

    Technologies pertaining to authenticating data output by sensors in an industrial environment are described herein. A sensor sentinel computing device receives time-series data from a sensor by way of a wireline connection. The sensor sentinel computing device generates a validation signal that is a function of the time-series signal. The sensor sentinel computing device then transmits the validation signal to a programmable logic controller in the industrial environment.

  19. Barrier breaching device

    DOEpatents

    Honodel, C.A.

    1983-06-01

    A barrier breaching device that is designed primarily for opening holes in interior walls of buildings uses detonating fuse for explosive force. The fuse acts as the ribs or spokes of an umbrella-like device that may be opened up to form a cone. The cone is placed against the wall so that detonating fuse that rings the base of the device and which is ignited by the spoke-like fuses serves to cut a circular hole in the wall.

  20. Barrier breaching device

    DOEpatents

    Honodel, Charles A.

    1985-01-01

    A barrier breaching device that is designed primarily for opening holes in interior walls of buildings uses detonating fuse for explosive force. The fuse acts as the ribs or spokes of an umbrella-like device that may be opened up to form a cone. The cone is placed against the wall so that detonating fuse that rings the base of the device and which is ignited by the spoke-like fuses serves to cut a circular hole in the wall.

  1. 22q11.2 deletion syndrome.

    PubMed

    McDonald-McGinn, Donna M; Sullivan, Kathleen E; Marino, Bruno; Philip, Nicole; Swillen, Ann; Vorstman, Jacob A S; Zackai, Elaine H; Emanuel, Beverly S; Vermeesch, Joris R; Morrow, Bernice E; Scambler, Peter J; Bassett, Anne S

    2015-01-01

    22q11.2 deletion syndrome (22q11.2DS) is the most common chromosomal microdeletion disorder, estimated to result mainly from de novo non-homologous meiotic recombination events occurring in approximately 1 in every 1,000 fetuses. The first description in the English language of the constellation of findings now known to be due to this chromosomal difference was made in the 1960s in children with DiGeorge syndrome, who presented with the clinical triad of immunodeficiency, hypoparathyroidism and congenital heart disease. The syndrome is now known to have a heterogeneous presentation that includes multiple additional congenital anomalies and later-onset conditions, such as palatal, gastrointestinal and renal abnormalities, autoimmune disease, variable cognitive delays, behavioural phenotypes and psychiatric illness - all far extending the original description of DiGeorge syndrome. Management requires a multidisciplinary approach involving paediatrics, general medicine, surgery, psychiatry, psychology, interventional therapies (physical, occupational, speech, language and behavioural) and genetic counselling. Although common, lack of recognition of the condition and/or lack of familiarity with genetic testing methods, together with the wide variability of clinical presentation, delays diagnosis. Early diagnosis, preferably prenatally or neonatally, could improve outcomes, thus stressing the importance of universal screening. Equally important, 22q11.2DS has become a model for understanding rare and frequent congenital anomalies, medical conditions, psychiatric and developmental disorders, and may provide a platform to better understand these disorders while affording opportunities for translational strategies across the lifespan for both patients with 22q11.2DS and those with these associated features in the general population. PMID:27189754

  2. 9q22 Deletion - First Familial Case

    PubMed Central

    2011-01-01

    Background Only 29 cases of constitutional 9q22 deletions have been published and all have been sporadic. Most associate with Gorlin syndrome or nevoid basal cell carcinoma syndrome (NBCCS, MIM #109400) due to haploinsufficiency of the PTCH1 gene (MIM *601309). Methods and Results We report two mentally retarded female siblings and their cognitively normal father, all carrying a similar 5.3 Mb microdeletion at 9q22.2q22.32, detected by array CGH (244 K). The deletion does not involve the PTCH1 gene, but instead 30 other gene,s including the ROR2 gene (MIM *602337) which causing both brachydactyly type 1 (MIM #113000) and Robinow syndrome (MIM #268310), and the immunologically active SYK gene (MIM *600085). The deletion in the father was de novo and FISH analysis of blood lymphocytes did not suggest mosaicism. All three patients share similar mild dysmorphic features with downslanting palpebral fissures, narrow, high bridged nose with small nares, long, deeply grooved philtrum, ears with broad helix and uplifted lobuli, and small toenails. All have significant dysarthria and suffer from continuous middle ear and upper respiratory infections. The father also has a funnel chest and unilateral hypoplastic kidney but the daughters have no malformations. Conclusions This is the first report of a familial constitutional 9q22 deletion and the first deletion studied by array-CGH which does not involve the PTCH1 gene. The phenotype and penetrance are variable and the deletion found in the cognitively normal normal father poses a challenge in genetic counseling. PMID:21693067

  3. Multiple acousto-optic q-switch

    DOEpatents

    Deason, Vance A.

    1993-01-01

    An improved dynamic moire interferometer comprised of a lasing medium providing a plurality of beams of coherent light, a multiple q-switch producing multiple trains of 100,000 or more pulses per second, a combining means collimating multiple trains of pulses into substantially a single train and directing beams to specimen gratings affixed to a test material, and a controller, triggering and sequencing the emission of the pulses with the occurrence and recording of a dynamic loading event.

  4. Multiple acousto-optic q-switch

    DOEpatents

    Deason, Vance A.

    1993-12-07

    An improved dynamic moire interferometer comprised of a lasing medium providing a plurality of beams of coherent light, a multiple q-switch producing multiple trains of 100,000 or more pulses per second, a combining means collimating multiple trains of pulses into substantially a single train and directing beams to specimen gratings affixed to a test material, and a controller, triggering and sequencing the emission of the pulses with the occurrence and recording of a dynamic loading event.

  5. Gravitational effects on critical Q-balls

    NASA Astrophysics Data System (ADS)

    Metaxas, D.

    2007-04-01

    In a cosmological phase transition in theories that admit Q-balls there is a value of the soliton charge above which the soliton becomes unstable and expands, converting space to the true vacuum, much like a critical bubble in the case of ordinary tunneling. Here I consider the effects of gravity on these solitons and I calculate the lowest gravitational corrections to the critical radius and charge.

  6. Lumped elements characterize Q in dielectric resonators

    NASA Technical Reports Server (NTRS)

    Hearn, Chase P.

    1993-01-01

    It has been earlier observed (Podcameni et al., 1981) that, as the coupling factor between a microstrip-coupled dielectric resonator and the line becomes much larger than unity, the unloaded quality factor (Q) of the resonator decreases. In this paper it is shown that this effect can be explained using lumped-element models of the coupling line, when the dielectric resonator is either overcoupled or undercoupled to the line.

  7. The Rebirth of D-Q University

    ERIC Educational Resources Information Center

    Valdata, Patricia

    2006-01-01

    The Phoenix is a traditional symbol of rebirth, but for D-Q University, a bolt cutter may be a more appropriate image. After more than 30 years as California's only two-year tribal college, the school lost its accreditation in January 2005. The board of directors tried to keep the school open, but last summer they began packing up student records,…

  8. 22q11.2 deletion syndrome

    PubMed Central

    McDonald-McGinn, Donna M.; Sullivan, Kathleen E.; Marino, Bruno; Philip, Nicole; Swillen, Ann; Vorstman, Jacob A. S.; Zackai, Elaine H.; Emanuel, Beverly S.; Vermeesch, Joris R.; Morrow, Bernice E.; Scambler, Peter J.; Bassett, Anne S.

    2016-01-01

    22q11.2 deletion syndrome (22q11.2DS) is the most common chromosomal microdeletion disorder, estimated to result mainly from de novo non-homologous meiotic recombination events occurring in approximately 1 in every 1,000 fetuses. The first description in the English language of the constellation of findings now known to be due to this chromosomal difference was made in the 1960s in children with DiGeorge syndrome, who presented with the clinical triad of immunodeficiency, hypoparathyroidism and congenital heart disease. The syndrome is now known to have a heterogeneous presentation that includes multiple additional congenital anomalies and later-onset conditions, such as palatal, gastrointestinal and renal abnormalities, autoimmune disease, variable cognitive delays, behavioural phenotypes and psychiatric illness — all far extending the original description of DiGeorge syndrome. Management requires a multidisciplinary approach involving paediatrics, general medicine, surgery, psychiatry, psychology, interventional therapies (physical, occupational, speech, language and behavioural) and genetic counselling. Although common, lack of recognition of the condition and/or lack of familiarity with genetic testing methods, together with the wide variability of clinical presentation, delays diagnosis. Early diagnosis, preferably prenatally or neonatally, could improve outcomes, thus stressing the importance of universal screening. Equally important, 22q11.2DS has become a model for understanding rare and frequent congenital anomalies, medical conditions, psychiatric and developmental disorders, and may provide a platform to better understand these disorders while affording opportunities for translational strategies across the lifespan for both patients with 22q11.2DS and those with these associated features in the general population. PMID:27189754

  9. New Medical Device Evaluation.

    PubMed

    Ikeda, Koji

    2016-01-01

    In this presentation, as a member of the Harmonization by Doing (HBD) project, I discuss the significance of regulatory science in global medical device development and our experience in the international collaboration process for medical devices. In Japan, most innovative medical therapeutic devices were previously developed and exported by foreign-based companies. Due to this device lag, Japanese had minimal opportunities for receiving treatment with innovative medical devices. To address this issue, the Japanese government has actively accepted foreign clinical trial results and promoted global clinical trials in projects such as HBD. HBD is a project with stakeholders from academia, regulatory authorities, and industry in the US and Japan to promote global clinical trials and reduce device lags. When the project started, medical device clinical trials were not actively conducted in Japan at not just hospitals but also at medical device companies. We started to identify issues under the concept of HBD. After 10 years, we have now become key members in global clinical trials and able to obtain approvals without delay. Recently, HBD has started promoting international convergence. Physicians and regulatory authorities play central roles in compiling guidelines for the clinical evaluation of medical device development, which will be a more active field in the near future. The guidelines compiled will be confirmed with members of academia and regulatory authorities in the United Sates. PMID:27040333

  10. High efficiency photovoltaic device

    DOEpatents

    Guha, Subhendu; Yang, Chi C.; Xu, Xi Xiang

    1999-11-02

    An N-I-P type photovoltaic device includes a multi-layered body of N-doped semiconductor material which has an amorphous, N doped layer in contact with the amorphous body of intrinsic semiconductor material, and a microcrystalline, N doped layer overlying the amorphous, N doped material. A tandem device comprising stacked N-I-P cells may further include a second amorphous, N doped layer interposed between the microcrystalline, N doped layer and a microcrystalline P doped layer. Photovoltaic devices thus configured manifest improved performance, particularly when configured as tandem devices.

  11. Active multistable twisting device

    NASA Technical Reports Server (NTRS)

    Schultz, Marc R. (Inventor)

    2008-01-01

    Two similarly shaped, such as rectangular, shells are attached to one another such that they form a resulting thin airfoil-like structure. The resulting device has at least two stable equilibrium shapes. The device can be transformed from one shape to another with a snap-through action. One or more actuators can be used to effect the snap-through; i.e., transform the device from one stable shape to another. Power to the actuators is needed only to transform the device from one shape to another.

  12. Benchmarking emerging logic devices

    NASA Astrophysics Data System (ADS)

    Nikonov, Dmitri

    2014-03-01

    As complementary metal-oxide-semiconductor field-effect transistors (CMOS FET) are being scaled to ever smaller sizes by the semiconductor industry, the demand is growing for emerging logic devices to supplement CMOS in various special functions. Research directions and concepts of such devices are overviewed. They include tunneling, graphene based, spintronic devices etc. The methodology to estimate future performance of emerging (beyond CMOS) devices and simple logic circuits based on them is explained. Results of benchmarking are used to identify more promising concepts and to map pathways for improvement of beyond CMOS computing.

  13. Ion trap device

    DOEpatents

    Ibrahim, Yehia M.; Smith, Richard D.

    2016-01-26

    An ion trap device is disclosed. The device includes a series of electrodes that define an ion flow path. A radio frequency (RF) field is applied to the series of electrodes such that each electrode is phase shifted approximately 180 degrees from an adjacent electrode. A DC voltage is superimposed with the RF field to create a DC gradient to drive ions in the direction of the gradient. A second RF field or DC voltage is applied to selectively trap and release the ions from the device. Further, the device may be gridless and utilized at high pressure.

  14. Pyrotechnic device technology

    SciTech Connect

    Wilcox, P.D.

    1989-01-01

    This talk was given at the 14th International Pyrotechnic Seminar on September 21, 1989, in Jersey, United Kingdom, as one of two plenary lectures. It briefly surveys the current technology of pyrotechnic devices and examines trends for the future. The pyrotechnic'' can have several meanings. In this talk, pyrotechnic devices'' are devices in which porous materials undergo reduction-oxidation reactions and produce useful products. The pyrotechnic materials are generally fuel-oxidizer systems without binders, in contrast to primary or secondary explosives or propellants. The word pyrotechnic'' is often used to include explosive, squib, propellant, or other ordnance type devices, especially in the European community. The major need for pyrotechnic devices has always been military and defense; however, as technology advances, the civilian uses of pyrotechnics will continue to grow. If every automobile had a pyrotechnic device to trigger its air or crash bag, that application alone would mean millions of devices per year. Applications in safety, fire fighting, law enforcement, and other commercial applications are likely to increase due to the increased capability of pyrotechnic devices and the integration of such devices in system designs. 2 refs., 56 figs.

  15. Interconnected semiconductor devices

    DOEpatents

    Grimmer, Derrick P.; Paulson, Kenneth R.; Gilbert, James R.

    1990-10-23

    Semiconductor layer and conductive layer formed on a flexible substrate, divided into individual devices and interconnected with one another in series by interconnection layers and penetrating terminals.

  16. {sigma}{sub Q}{lambda}{sub Q}{pi} coupling constant in light cone QCD sum rules

    SciTech Connect

    Azizi, K.; Bayar, M.; Ozpineci, A.

    2009-03-01

    The strong coupling constants g{sub {sigma}{sub Q}}Q{sub {lambda}{sub Q}}{sub {pi}} (Q=b and c) are studied in the framework of the light cone QCD sum rules using the most general form of the baryonic currents. The predicted coupling constants are used to estimate the decay widths for the {sigma}{sub Q}{yields}{lambda}{sub Q}{pi} decays which are compared with the predictions of the other approaches and existing experimental data.

  17. Q fever pneumonia in children in Japan.

    PubMed Central

    To, H; Kako, N; Zhang, G Q; Otsuka, H; Ogawa, M; Ochiai, O; Nguyen, S V; Yamaguchi, T; Fukushi, H; Nagaoka, N; Akiyama, M; Amano, K; Hirai, K

    1996-01-01

    The prevalence of Q fever pneumonia among children with atypical pneumonia from whom only an acute-phase serum sample was available was traced by using an indirect immunofluorescence (IF) test, nested PCR, and isolation. Twenty (34.5%) of 58 sera were found to have both polyvalent and immunoglobulin M antibodies to the phase II antigen of Coxiella burnetii by the IF test. Q fever pneumonia was present in 23 (39.7%) of 58 patients as determined by both the nested PCR and isolation and in 20 patients as determined by the IF test. The sensitivities for nested PCR and isolation were 100%, and that for the IF test was 87%. Our results indicate that nested PCR was faster and more sensitive than isolation and the IF test in the diagnosis of acute Q fever when a single acute-phase serum was available. These findings suggest that C. burnetii is an important cause of atypical pneumonia in children in Japan. PMID:8904431

  18. THE Q/U IMAGING EXPERIMENT INSTRUMENT

    SciTech Connect

    Bischoff, C.; Brizius, A.; Buder, I.; Kusaka, A.; Smith, K. M.; Bogdan, M.; Chinone, Y.; Cleary, K.; Reeves, R.; Monsalve, R.; Bustos, R.; Naess, S. K.; Nixon, G.; Vanderlinde, K.; Wehus, I. K.; Church, S. E.; Davis, R.; Dickinson, C.; and others

    2013-05-01

    The Q/U Imaging ExperimenT (QUIET) is designed to measure polarization in the cosmic microwave background, targeting the imprint of inflationary gravitational waves at large angular scales({approx}1 Degree-Sign ). Between 2008 October and 2010 December, two independent receiver arrays were deployed sequentially on a 1.4 m side-fed Dragonian telescope. The polarimeters that form the focal planes use a compact design based on high electron mobility transistors (HEMTs) that provides simultaneous measurements of the Stokes parameters Q, U, and I in a single module. The 17-element Q-band polarimeter array, with a central frequency of 43.1 GHz, has the best sensitivity (69 {mu}Ks{sup 1/2}) and the lowest instrumental systematic errors ever achieved in this band, contributing to the tensor-to-scalar ratio at r < 0.1. The 84-element W-band polarimeter array has a sensitivity of 87 {mu}Ks{sup 1/2} at a central frequency of 94.5 GHz. It has the lowest systematic errors to date, contributing at r < 0.01. The two arrays together cover multipoles in the range l {approx} 25-975. These are the largest HEMT-based arrays deployed to date. This article describes the design, calibration, performance, and sources of systematic error of the instrument.

  19. Percolation in one of q colors near criticality

    NASA Astrophysics Data System (ADS)

    Qian, Xiaofeng; Deng, Youjin; Blöte, Henk W. J.

    2005-04-01

    We study bond percolation in two dimensions between random site variables having one out of q colors, using transfer-matrix and Monte Carlo techniques. We determine the percolation threshold as a function of the Potts temperature T in the disordered Potts range Tc⩽T<∞ for several q -state Potts Hamiltonians. For high T , these transitions fit, irrespective of q , in the universality class of the ordinary percolation transitions. However, for T↓Tc , q -dependent crossover phenomena appear. The topology of the phase diagram changes in a qualitative sense at q=2 . For q<2 the Potts critical state appears to enhance percolation, for q>2 it appears to suppress it. Remarkably, for q=2 the percolation line coincides with the only flow line extending to T>Tc from the critical fixed point associated with Potts clusters.

  20. Novel properties of the q-analogue quantized radiation field

    NASA Technical Reports Server (NTRS)

    Nelson, Charles A.

    1993-01-01

    The 'classical limit' of the q-analog quantized radiation field is studied paralleling conventional quantum optics analyses. The q-generalizations of the phase operator of Susskind and Glogower and that of Pegg and Barnett are constructed. Both generalizations and their associated number-phase uncertainty relations are manifestly q-independent in the n greater than g number basis. However, in the q-coherent state z greater than q basis, the variance of the generic electric field, (delta(E))(sup 2) is found to be increased by a factor lambda(z) where lambda(z) greater than 1 if q not equal to 1. At large amplitudes, the amplitude itself would be quantized if the available resolution of unity for the q-analog coherent states is accepted in the formulation. These consequences are remarkable versus the conventional q = 1 limit.

  1. Condition for equivalence of q-deformed and anharmonic oscillators

    NASA Technical Reports Server (NTRS)

    Artoni, M.; Zang, Jun; Birman, Joseph L.

    1993-01-01

    The equivalence between the q-deformed harmonic oscillator and a specific anharmonic oscillator model, by which some new insight into the problem of the physical meaning of the parameter q can be attained, are discussed.

  2. Antibunching Effect of Kappa-Component Q-Coherent States

    NASA Technical Reports Server (NTRS)

    He, Jinyu; Wang, Jisuo; Wang, Chuankui

    1996-01-01

    We introduce the antibunching effect for the q-electromagnetic field, and study this kind nonclassical properties of k-component q-coherent states given by Kuang et al. The results show that all of them show antibunching effect.

  3. Novel features of 3q29 deletion syndrome: Results from the 3q29 registry.

    PubMed

    Glassford, Megan R; Rosenfeld, Jill A; Freedman, Alexa A; Zwick, Michael E; Mulle, Jennifer G

    2016-04-01

    3q29 deletion syndrome is caused by a recurrent, typically de novo heterozygous 1.6 Mb deletion, but because incidence of the deletion is rare (1 in 30,000 births) the phenotype is not well described. To characterize the range of phenotypic manifestations associated with 3q29 deletion syndrome, we have developed an online registry (3q29deletion.org) for ascertainment of study subjects and phenotypic data collection via Internet-based survey instruments. We report here on data collected during the first 18 months of registry operation, from 44 patients. This is the largest cohort of 3q29 deletion carriers ever assembled and surveyed in a systematic way. Our data reveal that 28% of registry participants report neuropsychiatric phenotypes, including anxiety disorder, panic attacks, depression, bipolar disorder, and schizophrenia. Other novel findings include a high prevalence (64%) of feeding problems in infancy and reduced weight at birth for 3q29 deletion carriers (average reduction 13.9 oz (394 g), adjusted for gestational age and sex, P = 6.5e-07). We further report on the frequency of heart defects, autism, recurrent ear infections, gastrointestinal phenotypes, and dental phenotypes, among others. We also report on the expected timing of delayed developmental milestones. This is the most comprehensive description of the 3q29 deletion phenotype to date. These results are clinically actionable toward improving patient care for 3q29 deletion carriers, and can guide the expectations of physicians and parents. These data also demonstrate the value of patient-reported outcomes to reveal the full phenotypic spectrum of rare genomic disorders. © 2016 Wiley Periodicals, Inc. PMID:26738761

  4. Novel features of 3q29 deletion syndrome: Results from the 3q29 registry

    PubMed Central

    Glassford, Megan R.; Rosenfeld, Jill A.; Freedman, Alexa A.; Zwick, Michael E.

    2016-01-01

    3q29 deletion syndrome is caused by a recurrent, typically de novo heterozygous 1.6 Mb deletion, but because incidence of the deletion is rare (1 in 30,000 births) the phenotype is not well described. To characterize the range of phenotypic manifestations associated with 3q29 deletion syndrome, we have developed an online registry (3q29deletion.org) for ascertainment of study subjects and phenotypic data collection via Internet‐based survey instruments. We report here on data collected during the first 18 months of registry operation, from 44 patients. This is the largest cohort of 3q29 deletion carriers ever assembled and surveyed in a systematic way. Our data reveal that 28% of registry participants report neuropsychiatric phenotypes, including anxiety disorder, panic attacks, depression, bipolar disorder, and schizophrenia. Other novel findings include a high prevalence (64%) of feeding problems in infancy and reduced weight at birth for 3q29 deletion carriers (average reduction 13.9 oz (394 g), adjusted for gestational age and sex, P = 6.5e‐07). We further report on the frequency of heart defects, autism, recurrent ear infections, gastrointestinal phenotypes, and dental phenotypes, among others. We also report on the expected timing of delayed developmental milestones. This is the most comprehensive description of the 3q29 deletion phenotype to date. These results are clinically actionable toward improving patient care for 3q29 deletion carriers, and can guide the expectations of physicians and parents. These data also demonstrate the value of patient‐reported outcomes to reveal the full phenotypic spectrum of rare genomic disorders. © 2016 The Authors. American Journal of Medical Genetics Part A Published by Wiley Periodicals, Inc. PMID:26738761

  5. Jupiter's Tidal Q: The Range of Uncertainty

    NASA Astrophysics Data System (ADS)

    Greenberg, Richard; Barnes, R.; Jackson, B.

    2008-09-01

    Jupiter's Q, which quantifies the net effect of poorly understood dissipative processes, is central to the physical and orbital history of the Galilean satellites and to studies of extra-solar planets. A standard procedure for determining orbits from observations of extra-solar planets is to estimate e-damping times, using for Q a "commonly accepted value” 105-106, based on supposed constraints on Jupiter's Q: If the damping time is short, orbits are assumed circular; if the data nevertheless require a finite e, it is attributed to perturbations by unseen planets. But those now-standard procedures are flawed because, in fact, there are no firm constraints on Jupiter's Q. Given the dynamics of the system and its Laplace resonance, knowledge of the tidal dissipation rate in Io (from heat flux) and of Io's orbital acceleration dn1/dt (from mutual occultations and eclipses) should determine the effective value of QJ. If the Laplace resonance were in an equilibrium steady-state, then either one of those measured values yield QJ. Aksnes and Franklin's ("A&F's” 2001) solution for dn1/dt of 3.6x10-10/yr and McEwen et al.'s (1992) Io heat flux 1.3x1014W, gives QJ=2x105, the solution A&F highlighted. However, slight changes from those measured values, well within the uncertainty range, would yield infinite QJ. Another fit to the mutual event data allowed dn1/dt=0, but A&F rejected this result because the implied QJ ( 3x104) was outside the conventionally accepted range. In fact, that range is based on the steady-state condition of the resonance (placing an upper limit on QJ) and on the assumption that dn1/dt<0; (which gives a lower limit), both of which are ruled out by A&F's results. Our study of tidal evolution of "hot Jupiters” (Jackson et al. 2008) suggests typical Q values of 106.5, somewhat above the widely assumed range, but below the real upper limit (infinity) for Jupiter.

  6. Four Novel Loci (19q13, 6q24, 12q24, and 5q14) Influence the Microcirculation In Vivo

    PubMed Central

    Ikram, M. Arfan; Wang, Jie Jin; Klein, Ronald; Klein, Barbara E. K.; Breteler, Monique M. B.; Cheung, Ning; Liew, Gerald; Mitchell, Paul; Uitterlinden, Andre G.; Rivadeneira, Fernando; Hofman, Albert; de Jong, Paulus T. V. M.; van Duijn, Cornelia M.; Kao, Linda; Cheng, Ching-Yu; Smith, Albert Vernon; Glazer, Nicole L.; Lumley, Thomas; McKnight, Barbara; Psaty, Bruce M.; Jonasson, Fridbert; Eiriksdottir, Gudny; Aspelund, Thor; Harris, Tamara B.; Launer, Lenore J.; Taylor, Kent D.; Li, Xiaohui; Iyengar, Sudha K.; Xi, Quansheng; Sivakumaran, Theru A.; Mackey, David A.; MacGregor, Stuart; Martin, Nicholas G.; Young, Terri L.; Bis, Josh C.; Wiggins, Kerri L.; Heckbert, Susan R.; Hammond, Christopher J.; Andrew, Toby; Fahy, Samantha; Attia, John; Holliday, Elizabeth G.; Scott, Rodney J.; Islam, F. M. Amirul; Rotter, Jerome I.; McAuley, Annie K.; Boerwinkle, Eric; Tai, E. Shyong; Gudnason, Vilmundur; Siscovick, David S.; Vingerling, Johannes R.; Wong, Tien Y.

    2010-01-01

    There is increasing evidence that the microcirculation plays an important role in the pathogenesis of cardiovascular diseases. Changes in retinal vascular caliber reflect early microvascular disease and predict incident cardiovascular events. We performed a genome-wide association study to identify genetic variants associated with retinal vascular caliber. We analyzed data from four population-based discovery cohorts with 15,358 unrelated Caucasian individuals, who are members of the Cohort for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium, and replicated findings in four independent Caucasian cohorts (n = 6,652). All participants had retinal photography and retinal arteriolar and venular caliber measured from computer software. In the discovery cohorts, 179 single nucleotide polymorphisms (SNP) spread across five loci were significantly associated (p<5.0×10−8) with retinal venular caliber, but none showed association with arteriolar caliber. Collectively, these five loci explain 1.0%–3.2% of the variation in retinal venular caliber. Four out of these five loci were confirmed in independent replication samples. In the combined analyses, the top SNPs at each locus were: rs2287921 (19q13; p = 1.61×10−25, within the RASIP1 locus), rs225717 (6q24; p = 1.25×10−16, adjacent to the VTA1 and NMBR loci), rs10774625 (12q24; p = 2.15×10−13, in the region of ATXN2,SH2B3 and PTPN11 loci), and rs17421627 (5q14; p = 7.32×10−16, adjacent to the MEF2C locus). In two independent samples, locus 12q24 was also associated with coronary heart disease and hypertension. Our population-based genome-wide association study demonstrates four novel loci associated with retinal venular caliber, an endophenotype of the microcirculation associated with clinical cardiovascular disease. These data provide further insights into the contribution and biological mechanisms of microcirculatory changes that underlie cardiovascular disease. PMID

  7. A compact and efficient four-wavelength Q-switched Nd:YAP laser

    NASA Astrophysics Data System (ADS)

    Huang, C. H.; Zhang, G.; Wei, Y.; Zhu, H. Y.; Huang, L. X.

    2010-04-01

    In this paper, a four-wavelength electro-optic (E-O) Q-switched solid-state laser system was presented. This laser system only use one Nd:YAP laser crystal, which irradiates 1079.5 nm and 1341.4 nm fundamental wavelengths. Both of these wavelength lasers and their second harmonic generation (SHG) compose a four-wavelength Nd:YAP Q-switched laser. The Q-switched output energies of 277 mJ for 1079.5 nm and 61 mJ for 539.8 nm and that of 190 mJ for 1341.4 nm and 51 mJ for 670.7 nm wavelengths were achieved. The pulse durations of 1079.5 and 539.8 nm lasers and that of 1341.4 and 670.7 nm lasers are 20 and 40 ns, respectively. Due to this laser system has the larger chance and convenience for selecting the wavelengths and operation modes by moving a stepping motor and controlling the Q-switched devices, it will broaden applications in the fields of laser cosmetology, dermatotis therapy, material processing and laser display etc.

  8. Material and Phonon Engineering for Next Generation Acoustic Devices

    NASA Astrophysics Data System (ADS)

    Kuo, Nai-Kuei

    This thesis presents the theoretical and experimental work related to micromachining of low intrinsic loss sapphire and phononic crystals for engineering new classes of electroacoustic devices for frequency control applications. For the first time, a low loss sapphire suspended membrane was fabricated and utilized to form the main body of a piezoelectric lateral overtone bulk acoustic resonator (LOBAR). Since the metalized piezoelectric transducer area in a LOBAR is only a small fraction of the overall resonant cavity (made out of sapphire), high quality factor (Q) overtones are attained. The experiment confirms the low intrinsic mechanical loss of the transferred sapphire thin film, and the resonators exhibit the highest Q of 5,440 at 2.8 GHz ( f·Q of 1.53.1013 Hz). This is also the highest f·Q demonstrated for aluminum-nitride-(AIN)-based Lamb wave devices to date. Beyond demonstrating a low loss device, this experimental work has laid the foundation for the future development of new micromechanical devices based on a high Q, high hardness and chemically resilient material. The search for alternative ways to more efficiently perform frequency control functionalities lead to the exploration of Phononic Crystal (PnC) structures in AIN thin films. Four unit cell designs were theoretically and experimentally investigated to explore the behavior of phononic bandgaps (PBGs) in the ultra high frequency (UHF) range: (i) the conventional square lattice with circular air scatterer, (ii) the inverse acoustic bandgap (IABG) structure, (iii) the fractal PnC, and (iv) the X-shaped PnC. Each unit cell has its unique frequency characteristic that was exploited to synthesize either cavity resonators or improve the performance of acoustic delay lines. The PBGs operate in the range of 770 MHz to 1 GHz and exhibit a maximum acoustic rejection of 40 dB. AIN Lamb wave transducers (LWTs) were employed for the experimental demonstration of the PBGs and cavity resonances. Ultra

  9. 26 CFR 1.414(q)-1 - Highly compensated employee.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... the top-paid group for a year, the employees described in § 1.414(q)-1T, A-9(b)(1) (i), (ii) and (iii... to a qualified separate line of business. (i)-(iii) . See § 1.414(q)-1T, Q&A-9(b)(1) (i) through (iii) for further guidance. (2) Alternative exclusion provisions—(i)-(ii) . See § 1.414(q)-1T,...

  10. A Connection Formula for the q-Confluent Hypergeometric Function

    NASA Astrophysics Data System (ADS)

    Morita, Takeshi

    2013-07-01

    We show a connection formula for the q-confluent hypergeometric functions {}_2ϕ_1(a,b;0;q,x). Combining our connection formula with Zhang's connection formula for {}_2ϕ_0(a,b;-;q,x), we obtain the connection formula for the q-confluent hypergeometric equation in the matrix form. Also we obtain the connection formula of Kummer's confluent hypergeometric functions by taking the limit qto 1^{-} of our connection formula.

  11. New localization mechanism and Hodge duality for q -form field

    NASA Astrophysics Data System (ADS)

    Fu, Chun-E.; Liu, Yu-Xiao; Guo, Heng; Zhang, Sheng-Li

    2016-03-01

    In this paper, we investigate the problem of localization and the Hodge duality for a q -form field on a p -brane with codimension one. By a general Kaluza-Klein (KK) decomposition without gauge fixing, we obtain two Schrödinger-like equations for two types of KK modes of the bulk q -form field, which determine the localization and mass spectra of these KK modes. It is found that there are two types of zero modes (the 0-level modes): a q -form zero mode and a (q -1 )-form one, which cannot be localized on the brane at the same time. For the n -level KK modes, there are two interacting KK modes, a massive q -form KK mode and a massless (q -1 )-form one. By analyzing gauge invariance of the effective action and choosing a gauge condition, the n -level massive q -form KK mode decouples from the n -level massless (q -1 )-form one. It is also found that the Hodge duality in the bulk naturally becomes two dualities on the brane. The first one is the Hodge duality between a q -form zero mode and a (p -q -1 )-form one, or between a (q -1 )-form zero mode and a (p -q )-form one. The second duality is between two group KK modes: one is an n -level massive q -form KK mode with mass mn and an n -level massless (q -1 )-form mode; another is an n -level (p -q )-form one with the same mass mn and an n -level massless (p -q -1 )-form mode. Because of the dualities, the effective field theories on the brane for the KK modes of the two dual bulk form fields are physically equivalent.

  12. Mechanical Device Traces Parabolas

    NASA Technical Reports Server (NTRS)

    Soper, Terry A.

    1989-01-01

    Mechanical device simplifies generation of parabolas of various focal lengths. Based on fundamental geometrical construction of parabola. Constancy of critical total distance enforced by maintaining cable in tension. Applications of device include design of paraboloidal antennas, approximating catenaries on drawings of powerlines or long-wire antennas, and general tracing of parabolas on drawings.

  13. Devices and Educational Change

    ERIC Educational Resources Information Center

    Nespor, Jan

    2011-01-01

    This paper uses Actor Network Theory to examine two cases of device-mediated educational change, one involving a computer-assisted interactive video module that provided a half-hour of instruction for a university course, the other an assistive communication device that proved a supposedly retarded pre-school child to be intelligent. The paper…

  14. Self-actuated device

    DOEpatents

    Hecht, Samuel L.

    1984-01-01

    A self-actuated device, of particular use as a valve or an orifice for nuclear reactor fuel and blanket assemblies, in which a gas produced by a neutron induced nuclear reaction gradually accumulates as a function of neutron fluence. The gas pressure increase occasioned by such accumulation of gas is used to actuate the device.

  15. Advanced resistive exercise device

    NASA Technical Reports Server (NTRS)

    Raboin, Jasen L. (Inventor); Niebuhr, Jason (Inventor); Cruz, Santana F. (Inventor); Lamoreaux, Christopher D. (Inventor)

    2008-01-01

    The present invention relates to an exercise device, which includes a vacuum cylinder and a flywheel. The flywheel provides an inertial component to the load, which is particularly well suited for use in space as it simulates exercising under normal gravity conditions. Also, the present invention relates to an exercise device, which has a vacuum cylinder and a load adjusting armbase assembly.

  16. Device for removing blackheads

    DOEpatents

    Berkovich, Tamara

    1995-03-07

    A device for removing blackheads from pores in the skin having a elongated handle with a spoon shaped portion mounted on one end thereof, the spoon having multiple small holes piercing therethrough. Also covered is method for using the device to remove blackheads.

  17. Microfabricated particle focusing device

    DOEpatents

    Ravula, Surendra K.; Arrington, Christian L.; Sigman, Jennifer K.; Branch, Darren W.; Brener, Igal; Clem, Paul G.; James, Conrad D.; Hill, Martyn; Boltryk, Rosemary June

    2013-04-23

    A microfabricated particle focusing device comprises an acoustic portion to preconcentrate particles over large spatial dimensions into particle streams and a dielectrophoretic portion for finer particle focusing into single-file columns. The device can be used for high throughput assays for which it is necessary to isolate and investigate small bundles of particles and single particles.

  18. STORM INLET FILTRATION DEVICE

    EPA Science Inventory

    Five field tests were conducted to evaluate the effectiveness of the Storm and Groundwater Enhancement Systems (SAGES) device for removing contaminants from stormwater. The SAGES device is a three-stage filtering system that could be used as a best management practices (BMP) retr...

  19. Capillary interconnect device

    SciTech Connect

    Renzi, Ronald F

    2013-11-19

    An interconnecting device for connecting a plurality of first fluid-bearing conduits to a corresponding plurality of second fluid-bearing conduits thereby providing fluid communication between the first fluid-bearing conduits and the second fluid-bearing conduits. The device includes a manifold and one or two ferrule plates that are held by compressive axial forces.

  20. 40 CFR Appendixes Q-R to Part 51 - [Reserved

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 2 2010-07-01 2010-07-01 false Q Appendixes Q-R to Part 51 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS REQUIREMENTS FOR PREPARATION, ADOPTION, AND SUBMITTAL OF IMPLEMENTATION PLANS Appendixes Q-R to Part 51...

  1. 26 CFR 1.414(q)-1 - Highly compensated employee.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 5 2010-04-01 2010-04-01 false Highly compensated employee. 1.414(q)-1 Section 1.414(q)-1 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES Pension, Profit-Sharing, Stock Bonus Plans, Etc. § 1.414(q)-1...

  2. 40 CFR Appendixes Q-R to Part 51 - [Reserved

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 2 2013-07-01 2013-07-01 false Q Appendixes Q-R to Part 51 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS REQUIREMENTS FOR PREPARATION, ADOPTION, AND SUBMITTAL OF IMPLEMENTATION PLANS Appendixes Q-R to Part 51...

  3. 40 CFR Appendixes Q-R to Part 51 - [Reserved

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 2 2012-07-01 2012-07-01 false Q Appendixes Q-R to Part 51 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS REQUIREMENTS FOR PREPARATION, ADOPTION, AND SUBMITTAL OF IMPLEMENTATION PLANS Appendixes Q-R to Part 51...

  4. 40 CFR Appendixes Q-R to Part 51 - [Reserved

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 2 2011-07-01 2011-07-01 false Q Appendixes Q-R to Part 51 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS REQUIREMENTS FOR PREPARATION, ADOPTION, AND SUBMITTAL OF IMPLEMENTATION PLANS Appendixes Q-R to Part 51...

  5. 40 CFR Appendixes Q-R to Part 51 - [Reserved

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 2 2014-07-01 2014-07-01 false Q Appendixes Q-R to Part 51 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS REQUIREMENTS FOR PREPARATION, ADOPTION, AND SUBMITTAL OF IMPLEMENTATION PLANS Appendixes Q-R to Part 51...

  6. Genetics Home Reference: 22q11.2 deletion syndrome

    MedlinePlus

    ... Home Health Conditions 22q11.2 deletion syndrome 22q11.2 deletion syndrome Enable Javascript to view the expand/ ... Download PDF Open All Close All Description 22q11.2 deletion syndrome (which is also known by several ...

  7. Genetics Home Reference: 22q11.2 duplication

    MedlinePlus

    ... Genetics Home Health Conditions 22q11.2 duplication 22q11.2 duplication Enable Javascript to view the expand/collapse ... Download PDF Open All Close All Description 22q11.2 duplication is a condition caused by an extra ...

  8. Genetics Home Reference: 1q21.1 microduplication

    MedlinePlus

    ... Genetics Home Health Conditions 1q21.1 microduplication 1q21.1 microduplication Enable Javascript to view the expand/collapse ... Download PDF Open All Close All Description 1q21.1 microduplication is a chromosomal change in which a ...

  9. Genetics Home Reference: 9q22.3 microdeletion

    MedlinePlus

    ... Genetics Home Health Conditions 9q22.3 microdeletion 9q22.3 microdeletion Enable Javascript to view the expand/collapse ... Download PDF Open All Close All Description 9q22.3 microdeletion is a chromosomal change in which a ...

  10. Genetics Home Reference: 22q13.3 deletion syndrome

    MedlinePlus

    ... Home Health Conditions 22q13.3 deletion syndrome 22q13.3 deletion syndrome Enable Javascript to view the expand/ ... Download PDF Open All Close All Description 22q13.3 deletion syndrome , which is also commonly known as ...

  11. 20 CFR 404.1519q - Conflict of interest.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false Conflict of interest. 404.1519q Section 404.1519q Employees' Benefits SOCIAL SECURITY ADMINISTRATION FEDERAL OLD-AGE, SURVIVORS AND DISABILITY... Content § 404.1519q Conflict of interest. All implications of possible conflict of interest...

  12. 20 CFR 416.919q - Conflict of interest.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false Conflict of interest. 416.919q Section 416.919q Employees' Benefits SOCIAL SECURITY ADMINISTRATION SUPPLEMENTAL SECURITY INCOME FOR THE AGED... Report Content § 416.919q Conflict of interest. All implications of possible conflict of interest...

  13. Differential V-Q Ability: Twenty Years Later

    ERIC Educational Resources Information Center

    McCarthy, S. Viterbo

    1975-01-01

    The initial portion of this paper addresses itself to some of the methodological concerns associated with Verbal-Quantitative (V-Q) research. The second section focuses on studies using differential V-Q ability as an independent variable. The final section focuses on reasearch using V-Q ability measures as dependent variables. (Author/BJG)

  14. Solutions of q-deformed equations with quantum conformal symmetry

    SciTech Connect

    Dobrev, V. K.; Kostadinov, B. S.; Petrov, S. T.

    1998-12-15

    We consider the construction of explicit solutions of a hierarchy of q-deformed equations which are (conditionally) quantum conformal invariant. We give two types of solutions--polynomial solutions and solutions in terms of q-deformation of the plane wave. We give a q-deformation of the plane wave as a formal power series in the noncommutative coordinates of q-Minkowski space-time and four-momenta. This q-plane wave has analogous properties to the classical one, in particular, it has the properties of q-Lorentz covariance, and it satisfies the q-d'Alembert equation on the q-Lorentz covariant momentum cone. On the other hand, this q-plane wave is not an exponent or q-exponent. Thus, it differs conceptually from the classical plane wave and may serve as a its regularization. Using this we give also solutions of the massless Dirac equation involving two conjugated q-plane waves--one for the neutrino, the other for the antineutrino. It is also interesting that the neutrino solutions are deformed only through the q-pane wave, while the prefactor is classical. Thus, we can speak of a definite left-right asymmetry of the quantum conformal deformation of the neutrino-antineutrino system.

  15. Electro-optic Q-switch driver design specifics

    NASA Astrophysics Data System (ADS)

    Melnikov, Konstantin

    2010-07-01

    Different schematic designs of Q-Switch Drivers for Pockels Cell based optical arrangement are considered. Schematic solutions of Q-Switch driver design are analyzed. Marx Bank based Generator and High Voltage Switch Schematics are compared. Parameters of constructed Q-Switch Drivers are presented.

  16. Electro-optic Q-switch driver design specifics

    NASA Astrophysics Data System (ADS)

    Melnikov, Konstantin

    2011-03-01

    Different schematic designs of Q-Switch Drivers for Pockels Cell based optical arrangement are considered. Schematic solutions of Q-Switch driver design are analyzed. Marx Bank based Generator and High Voltage Switch Schematics are compared. Parameters of constructed Q-Switch Drivers are presented.

  17. Structure and function of preQ1 riboswitches

    PubMed Central

    Eichhorn, Catherine D.; Kang, Mijeong; Feigon, Juli

    2014-01-01

    PreQ1 riboswitches help regulate the biosynthesis and transport of PreQ1 (7-aminomethyl-7-deazaguanine), a precursor of the hypermodified guanine nucleotide queuosine (Q), in a number of Firmicutes, Proteobacteria, and Fusobacteria. Queuosine is almost universally found at the wobble position of the anticodon in asparaginyl, tyrosyl, histidyl and aspartyl tRNAs, where it contributes to translational fidelity. Two classes of PreQ1 riboswitches have been identified (PreQ1-I and PreQ1-II), and structures of examples from both classes have been determined. Both classes form H-type pseudoknots upon PreQ1 binding, each of which has distinct unusual features and modes of PreQ1 recognition. These features include an unusually long loop 2 in PreQ1-I pseudoknots and an embedded hairpin in loop 3 in PreQ1-II pseudoknots. PreQ1-I riboswitches are also notable for their unusually small aptamer domain, which has been extensively investigated by NMR, X-ray crystallography, FRET, and other biophysical methods. Here we review the discovery, structural biology, ligand specificity, cation interactions, folding, and dynamics, and applications to biotechnology of PreQ1 riboswitches. PMID:24798077

  18. Spin waves in triple-q structures: Application to USb

    SciTech Connect

    Jensen, J.; Bak, P.

    1981-06-01

    The spin-wave spectrum in a system with triple-q magnetic structure is calculated. The spin waves differ distinctly from those in the corresponding single-q structure, but agree with the excitations observed by Lander and Stirling in uranium antimonide (USb). Their experiments thus directly verify that the spins in USb are ordered in the triple-q structure.

  19. Heat tube device

    NASA Technical Reports Server (NTRS)

    Khattar, Mukesh K. (Inventor)

    1990-01-01

    The present invention discloses a heat tube device through which a working fluid can be circulated to transfer heat to air in a conventional air conditioning system. The heat tube device is disposable about a conventional cooling coil of the air conditioning system and includes a plurality of substantially U-shaped tubes connected to a support structure. The support structure includes members for allowing the heat tube device to be readily positioned about the cooling coil. An actuatable adjustment device is connected to the U-shaped tubes for allowing, upon actuation thereof, for the heat tubes to be simultaneously rotated relative to the cooling coil for allowing the heat transfer from the heat tube device to air in the air conditioning system to be selectively varied.

  20. Fluidic nanotubes and devices

    DOEpatents

    Yang, Peidong; He, Rongrui; Goldberger, Joshua; Fan, Rong; Wu, Yiying; Li, Deyu; Majumdar, Arun

    2008-04-08

    Fluidic nanotube devices are described in which a hydrophilic, non-carbon nanotube, has its ends fluidly coupled to reservoirs. Source and drain contacts are connected to opposing ends of the nanotube, or within each reservoir near the opening of the nanotube. The passage of molecular species can be sensed by measuring current flow (source-drain, ionic, or combination). The tube interior can be functionalized by joining binding molecules so that different molecular species can be sensed by detecting current changes. The nanotube may be a semiconductor, wherein a tubular transistor is formed. A gate electrode can be attached between source and drain to control current flow and ionic flow. By way of example an electrophoretic array embodiment is described, integrating MEMs switches. A variety of applications are described, such as: nanopores, nanocapillary devices, nanoelectrophoretic, DNA sequence detectors, immunosensors, thermoelectric devices, photonic devices, nanoscale fluidic bioseparators, imaging devices, and so forth.

  1. Fluidic nanotubes and devices

    DOEpatents

    Yang, Peidong; He, Rongrui; Goldberger, Joshua; Fan, Rong; Wu, Yiying; Li, Deyu; Majumdar, Arun

    2010-01-10

    Fluidic nanotube devices are described in which a hydrophilic, non-carbon nanotube, has its ends fluidly coupled to reservoirs. Source and drain contacts are connected to opposing ends of the nanotube, or within each reservoir near the opening of the nanotube. The passage of molecular species can be sensed by measuring current flow (source-drain, ionic, or combination). The tube interior can be functionalized by joining binding molecules so that different molecular species can be sensed by detecting current changes. The nanotube may be a semiconductor, wherein a tubular transistor is formed. A gate electrode can be attached between source and drain to control current flow and ionic flow. By way of example an electrophoretic array embodiment is described, integrating MEMs switches. A variety of applications are described, such as: nanopores, nanocapillary devices, nanoelectrophoretic, DNA sequence detectors, immunosensors, thermoelectric devices, photonic devices, nanoscale fluidic bioseparators, imaging devices, and so forth.

  2. Device for cutting protrusions

    DOEpatents

    Bzorgi, Fariborz M.

    2011-07-05

    An apparatus for clipping a protrusion of material is provided. The protrusion may, for example, be a bolt head, a nut, a rivet, a weld bead, or a temporary assembly alignment tab protruding from a substrate surface of assembled components. The apparatus typically includes a cleaver having a cleaving edge and a cutting blade having a cutting edge. Generally, a mounting structure configured to confine the cleaver and the cutting blade and permit a range of relative movement between the cleaving edge and the cutting edge is provided. Also typically included is a power device coupled to the cutting blade. The power device is configured to move the cutting edge toward the cleaving edge. In some embodiments the power device is activated by a momentary switch. A retraction device is also generally provided, where the retraction device is configured to move the cutting edge away from the cleaving edge.

  3. Planar electrochemical device assembly

    DOEpatents

    Jacobson; Craig P. , Visco; Steven J. , De Jonghe; Lutgard C.

    2010-11-09

    A pre-fabricated electrochemical device having a dense electrolyte disposed between an anode and a cathode preferably deposited as thin films is bonded to a porous electrically conductive support. A second porous electrically conductive support may be bonded to a counter electrode of the electrochemical device. Multiple electrochemical devices may be bonded in parallel to a single porous support, such as a perforated sheet to provide a planar array. Planar arrays may be arranged in a stacked interconnected array. A method of making a supported electrochemical device is disclosed wherein the method includes a step of bonding a pre-fabricated electrochemical device layer to an existing porous metal or porous metal alloy layer.

  4. Planar electrochemical device assembly

    DOEpatents

    Jacobson, Craig P.; Visco, Steven J.; De Jonghe, Lutgard C.

    2007-06-19

    A pre-fabricated electrochemical device having a dense electrolyte disposed between an anode and a cathode preferably deposited as thin films is bonded to a porous electrically conductive support. A second porous electrically conductive support may be bonded to a counter electrode of the electrochemical device. Multiple electrochemical devices may be bonded in parallel to a single porous support, such as a perforated sheet to provide a planar array. Planar arrays may be arranged in a stacked interconnected array. A method of making a supported electrochemical device is disclosed wherein the method includes a step of bonding a pre-fabricated electrochemical device layer to an existing porous metal or porous metal alloy layer.

  5. A New Case of 13q12.2q13.1 Microdeletion Syndrome Contributes to Phenotype Delineation

    PubMed Central

    Di Gregorio, Eleonora; Calcia, Alessandro; Savin, Elisa

    2014-01-01

    A recently described genetic disorder has been associated with 13q12.3 microdeletion spanning three genes, namely, KATNAL1, LINC00426, and HMGB1. Here, we report a new case with similar clinical features that we have followed from birth to 5 years old. The child carried a complex rearrangement with a double translocation: 46,XX,t(7;13)(p15;q14),t(11;15)(q23;q22). Array-CGH identified a de novo microdeletion at 13q12.2q13.1 spanning 3–3.4 Mb and overlapping 13q12.3 critical region. Clinical features resembling those reported in the literature confirm the existence of a distinct 13q12.3 microdeletion syndrome and provide further evidence that is useful to characterize its phenotypic expression during the 5 years of development. PMID:25506442

  6. High-Q silicon photonic crystal cavity for enhanced optical nonlinearities

    SciTech Connect

    Dharanipathy, Ulagalandha Perumal; Tonin, Mario; Houdré, Romuald; Minkov, Momchil Savona, Vincenzo

    2014-09-08

    We fabricate and experimentally characterize an H0 photonic crystal slab nanocavity with a design optimized for maximal quality factor, Q = 1.7 × 10{sup 6}. The cavity, fabricated from a silicon slab, has a resonant mode at λ = 1.59 μm and a measured Q-factor of 400 000. It displays nonlinear effects, including high-contrast optical bistability, at a threshold power among the lowest ever reported for a silicon device. With a theoretical modal volume as small as V = 0.34(λ/n){sup 3}, this cavity ranks among those with the highest Q/V ratios ever demonstrated, while having a small footprint suited for integration in photonic circuits.

  7. Medical devices; device tracking. Final rule.

    PubMed

    2002-02-01

    The Food and Drug Administration (FDA) is amending the medical device tracking regulation. FDA is making substantive changes to revise the scope of the regulation and add certain patient confidentiality requirements, and nonsubstantive changes to remove outdated references and simplify terminology. These revisions are made to conform the regulation to changes made in section 519(e) of the Federal Food, Drug, and Cosmetic Act (the act) by the FDA Modernization Act of 1997 (FDAMA), and to simplify certain requirements. PMID:11838471

  8. Remote power transfer using magneto-electric devices

    NASA Astrophysics Data System (ADS)

    Sinha, K.; Tabib-Azar, M.

    2015-12-01

    We report remote power transfer using magneto-electric devices. The experiments were performed at room temperature for piezoelectric beam coupled with electromagnet. Neodymium magnet was used as mass loading. We observed the output power of the order +19.3 to -71.1 dB given the gap between the input and output source was varied from 4 mm to 12 mm for the device (21.3 mm × 3.59 mm × 0.57 mm) with best performance at the resonance peak. We tested the device for frequency sweeps of 10-100 Hz and 100-5000 Hz. This enabled us to figure out the output power for the device at resonant frequencies over a wide frequency range. The device has high input impedance (as opposed to coils) and can be miniaturized aggressively to below 100 μm linear dimensions. The piezoelectric beams have much higher quality factors (Q) larger than 1000 while coils have low Qs (∼ 20) and the harvesting efficiency is proportional to Q.

  9. Ectrodactyly and tetralogy of Fallot in a fetus with del(6)(q21q23).

    PubMed

    Novikova, I V; Lazarevich, A A; Egorova, T M; Solovyeva, I V; Golovataja, E I; Plevako, T A; Mikheeva, N G; Lurie, I W

    2014-01-01

    We report a fetus with del(6)(q21q23) who had tetralogy of Fallot and ectrodactyly of the right hand. Analysis of the literature showed that both these defects were reported in several patients with similar deletions. The minimal segment responsible for ectrodactyly may be limited to 7.35 Mb (106.650.000-114.600.000). However 1) significant number of patients with this deletion but without ectrodactyly or other defects of extremities, and 2) wide range of unusual birth defects in some persons with deletions of the critical segment allow to propose involvement of regulatory element(s) necessary for the occurrence of ectrodactyly in patients with del 6q21. PMID:24783651

  10. Assignment of the Waldner blood group locus (WD) to 17q12-q21

    SciTech Connect

    Zelinski, T.; Coghlan, G.; White, L.

    1995-01-01

    The Waldner blood group antigen (WD1) was first recognized as a distinct erythrocyte surface structure in 1978. Occurring infrequently (incidence <1/1000) in random Caucasian blood samples, WD1 was assigned to the low-incidence (700) series by the International Society of Blood Transfusion (ISBT) working party on terminology for red cell surface antigens. To date, WD1 has been identified in Hutterites from Manitoba, in Khoisans from South Africa, and in a family from Holland. Despite the isolated occurrence of WD1 in different populations, we are fortunate to have the only documented sizeable collection of families segregating for WD. In this article, we report the results of genetic linkage analyses that demonstrate that WD is somewhat loosely linked to the reference marker D17S41 at 17q12-q24 and closely linked to the anion exchange protein 1 locus (AE1) at 17q12-21. 13 refs., 1 fig., 1 tab.

  11. The tyrosinase-positive oculocutaneous albinism locus maps to chromosome 15q11. 2-q12

    SciTech Connect

    Ramsay, M.; Colman, M.A.; Stevens, G.; Zwane, E.; Kromberg, J.; Jenkins, T. ); Garral, M.

    1992-10-01

    Tyrosinase-positive oculocutaneous albinism (ty-pos OCA), an autosomal recessive disorder of the melanin biosynthetic pathway, is the most common type of albinism occurring worldwide. In southern African Bantu-speaking negroids it has an overall prevalence of about 1/3,900. Since the basic biochemical defect is unknown, a linkage study with candidate loci, candidate chromosomal regions, and random loci was undertaken. The ty-pos OCA locus was found to be linked to two arbitrary loci, D15S10 and D15S13, in the Prader-Willi/Angelman chromosomal region on chromosome 15q11.2-q12. The pink-eyed dilute locus, p, on mouse chromosome 7, maps close to a region of homology on human chromosome 15q, and we postulate that the ty-pos OCA and p loci are homologous. 43 refs., 2 figs., 1 tab.

  12. On the Fourier - Gauss transforms of some q-exponential and q-trigonometric functions

    NASA Astrophysics Data System (ADS)

    Atakishiyev, N. M.

    1996-11-01

    We examine the properties of q-exponential and q-trigonometric functions, recently introduced and discussed in the literature. It is shown that they are related to Jackson's q-analogues of the exponential and trigonometric functions by classical Fourier - Gauss transformations.

  13. Novel pathways revealed in P. fluorescens Q2-87 and Q8r1-96

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Pseudomonas fluorescens Q2-87 and Q8r1-96, both from a take-all decline field in Quincy, Washington, U.S.A., are almost indistinguishable in vitro, but only strain Q8r1-96 exhibits the “premier” phenotype distinguished by highly aggressive wheat root colonizing ability essential for the natural dise...

  14. The q-G method : A q-version of the Steepest Descent method for global optimization.

    PubMed

    Soterroni, Aline C; Galski, Roberto L; Scarabello, Marluce C; Ramos, Fernando M

    2015-01-01

    In this work, the q-Gradient (q-G) method, a q-version of the Steepest Descent method, is presented. The main idea behind the q-G method is the use of the negative of the q-gradient vector of the objective function as the search direction. The q-gradient vector, or simply the q-gradient, is a generalization of the classical gradient vector based on the concept of Jackson's derivative from the q-calculus. Its use provides the algorithm an effective mechanism for escaping from local minima. The q-G method reduces to the Steepest Descent method when the parameter q tends to 1. The algorithm has three free parameters and it is implemented so that the search process gradually shifts from global exploration in the beginning to local exploitation in the end. We evaluated the q-G method on 34 test functions, and compared its performance with 34 optimization algorithms, including derivative-free algorithms and the Steepest Descent method. Our results show that the q-G method is competitive and has a great potential for solving multimodal optimization problems. PMID:26543781

  15. Clinical and genetic study of a family with a paternally inherited 15q11-q13 duplication.

    PubMed

    Marini, Carla; Cecconi, Antonella; Contini, Elisa; Pantaleo, Marilena; Metitieri, Tiziana; Guarducci, Silvia; Giglio, Sabrina; Guerrini, Renzo; Genuardi, Maurizio

    2013-06-01

    Interstitial chromosome 15q11-q13 duplications are associated with developmental delay, behavioral problems and additional manifestations, including epilepsy. In most affected individuals the duplicated chromosome is maternally derived, whereas paternal inheritance is more often associated with a normal phenotype. Seizures have not been described in patients with paternal dup 15q11-q13. We describe a family with five individuals in three generations with a paternally-inherited 15q11-q13 duplication, four of whom exhibited abnormal phenotypic characteristics, including seizures. The 18-year-old female proband presented with moderate intellectual disability, obesity, and epilepsy. Her brother manifested learning disability and behavioral problems. They both inherited the 15q11-q13 dup from their father who had a normal phenotype. Their paternal uncle and grandfather also had the duplication and were reported to have had seizures. Array-CGH and MLPA analyses showed that the duplication included the TUBGCP5, CYFIP1, MKRN3, MAGEL2, NDN, SNRPN, UBE3A, ATP10A, GABRB3, GABRA5, GABRG3, and OCA2 genes. This report provides evidence for intrafamilial phenotypic variability of paternal dup 15q11-q13, ranging from normal to intellectual disability and seizures, and potentially expanding the phenotype of paternal 15q11-q13 interstitial duplications. PMID:23633446

  16. Theory of the optimally coupled Q-switched laser

    SciTech Connect

    Degnan, J.J.

    1989-02-01

    The general equations describing Q-switched laser operation are transcendental in nature and require numerical solutions. This greatly complicates the optimization of real devices. In this paper, we demonstrate that, using the mathematical technique of Lagrange multipliers, one can derive simple analytic expressions for all of the key parameters of the optimally coupled laser, i.e., one which uses an optimum reflector to obtain maximum laser efficiency for a given pump level. These parameters (which include the optimum reflectivity, output energy, extraction efficiency, pulsewidth, peak power, etc.) can all be expressed as functions of a single dimensionless variable z, defined as the ratio of the unsaturated small-signal gain to the dissipative (non-useful) optical loss, multiplied by a few simple constants. Laser design tradeoff studies and performance projections can be accomplished quickly with the help of several graphs and a simple hand calculator. Sample calculations for a high-gain Nd:YAG and a low-gain alexandrite laser are presented as illustrations of the technique.

  17. Twin photon pairs in a high-Q silicon microresonator

    SciTech Connect

    Rogers, Steven; Lu, Xiyuan; Jiang, Wei C.; Lin, Qiang

    2015-07-27

    We report the generation of high-purity twin photon pairs through cavity-enhanced non-degenerate four-wave mixing (FWM) in a high-Q silicon microdisk resonator. Twin photon pairs are created within the same cavity mode and are consequently expected to be identical in all degrees of freedom. The device is able to produce twin photons at telecommunication wavelengths with a pair generation rate as large as (3.96 ± 0.03) × 10{sup 5} pairs/s, within a narrow bandwidth of 0.72 GHz. A coincidence-to-accidental ratio of 660 ± 62 was measured, the highest value reported to date for twin photon pairs, at a pair generation rate of (2.47 ± 0.04) × 10{sup 4} pairs/s. Through careful engineering of the dispersion matching window, we have reduced the ratio of photons resulting from degenerate FWM to non-degenerate FWM to less than 0.15.

  18. Characterization of rearrangements involving 4q, 13q and 16q in hepatocellular carcinoma cell lines using region-specific multiplex-FISH probes.

    PubMed

    Tjia, Wai Mui; Hu, Liang; Zhang, Min-Yue; Guan, Xin-Yuan

    2007-05-18

    Deletions in 4q, 13q and 16q were frequently detected in hepatocellular carcinoma (HCC) by comparative genomic hybridization (CGH) studies. However, detailed chromosome structural aberrations are not fully explored. Using CGH combined with multiplex-color FISH (M-FISH) with chromosome region-specific probes (CRPs), chromosome structural aberrations in 4q, 13q and 16q in six HCC cell lines were studied. All CRPs, which were generated from microdissected DNA, were specific, strong in intensity and sensitive enough to detect chromosome structural aberrations including translocation and deletion. FISH with BAC probes was used to further characterize translocation breakpoints and deletions. A breakpoint at 16q22 was localized at a BAC clone (RP11-341K23) and another breakpoint at 4q28 was localized within a 620 kb-region. A minimal deleted region at 13q21 was found between BAC clones RP11-240M20 and RP11-435P18. This study demonstrated that the combination of CGH, M-FISH and BAC-FISH is a very useful tool to detect and characterize translocation breakpoint. PMID:17098359

  19. Simulation analysis of three intubating supraglottic devices during infant chest compression.

    PubMed

    Kohama, Hanako; Komasawa, Nobuyasu; Ueki, Ryusuke; Kaminoh, Yoshiroh; Nishi, Shin-ichi

    2015-01-01

    Current guidelines for pediatric cardiopulmonary resuscitation suggest that supraglottic devices are alternatives for tracheal intubation with minimal interruption of chest compression. We examined the utility of three intubating supraglottic devices, air-Q® (air-Q), Ambu® aura-i (aura-i), and i-gel® (i-gel), utilizing manikin simulation. Twenty-two novice physicians performed securing of airway on an infant manikin with the three devices. We measured the rate of success on ventilation and the insertion time with or without chest compression. Successful ventilation rate did not significantly decrease with chest compression in the three devices (without chest compression: air-Q, 21/22; aura-i, 20/22; i-gel, 20/22, during chest compression: air-Q, 20/22; aura-i, 20/22; i-gel, 18/22). The insertion time with air-Q and aura-i did not extend significantly for chest compression. In contrast, the insertion time with i-gel was significantly extended in chest compression (P < 0.05). Air-Q and aura-i are more useful for airway management during chest compression than i-gel. PMID:25711262

  20. Mapping of the 3q27 region involved in Dup(3q) syndrome

    SciTech Connect

    Rizzu, P.; Baldini, A.; Overhauser, J.

    1994-09-01

    The duplication 3q syndrome is characterized by partial trisomy of a segment of the long arm of chromosome 3. We have previously found that 3q26.3-3q27 is the minimal region of trisomy overlap. This critical region (CR) is delimited by two patient chromosome breakpoints, approximately 10 cM apart. In order to identify the gene(s) responsible for the Dup(3q) phenotype, we are generating a physical map of the region and identifying expressed sequences. First, we have generated a cytological map using two- and three-color fluorescence in situ hybridization on metaphase and interphase chromosomes. Results allowed us to determine the centromere-telomere orientation, order and relative distances of six cosmid clones mapped to the CR. Because some of the markers used are part of the consensus chromosome 3 map, our data were easily integrated with existing mapping information. Subsequently, we have included in the map YAC clones positive for polymorphic PCR markers identified by CEPH-Genethon, as well as newly isolated YACs. We have assigned them to the critical region 7 of the Genethon polymorphic markers and linked them to three YAC contigs. Currently our map includes two of the five genes known to map in this region. Interestingly, we found that these two functionally related genes (kininogen and histidin-rich glycoprotein) map to the same 1 Mb genomic fragment. As the physical map is being constructed we are searching for expressed sequences. Positive cDNAs have been found and their characterization is in progress. In conclusion, we will present an integrated map of 3q27 that includes genetic, physical and cytological information as well as gene annotation. As Dup(3q) syndrome is likely to be a contiguous gene syndrome, such a map will be necessary for our understanding of this multiple congenital anomaly.

  1. Identification of SATB2 as the cleft palate gene on 2q32-q33.

    PubMed

    FitzPatrick, David R; Carr, Ian M; McLaren, Lorna; Leek, Jack P; Wightman, Patrick; Williamson, Kathy; Gautier, Philippe; McGill, Niolette; Hayward, Caroline; Firth, Helen; Markham, Alex F; Fantes, Judy A; Bonthron, David T

    2003-10-01

    Cytogenetic evidence, in the form of deletions and balanced translocations, points to the existence of a locus on 2q32-q33, for which haploinsufficiency results in isolated cleft palate (CPO). Here we show by high-resolution FISH mapping of two de novo CPO-associated translocations involving 2q32-q33 that one breakpoint interrupts the transcription unit of the gene encoding the DNA-binding protein SATB2 (formerly KIAA1034). The breakpoint in the other translocation is located 130 kb 3' to the SATB2 polyadenylation signal, within a conserved region of non-coding DNA. The SATB2 gene is transcribed in a telomeric to centromeric direction and lies in a gene-poor region of 2q32-q33; the nearest confirmed gene is 1.26 Mb centromeric to the SATB2 polyadenylation signal. SATB2-encoding transcripts are assembled from 11 exons that span 191 kb of genomic DNA. They encode a protein of 733 amino acids that has two CUT domains and a homeodomain and shows a remarkable degree of evolutionary conservation, with only three amino acid substitutions between mouse and human. This protein belongs to the same family as SATB1, a nuclear matrix-attachment region binding protein implicated in transcriptional control and control of chromatin remodelling. There are also sequence similarities to the Drosophila protein DVE. Whole mount in situ hybridization to mouse embryos shows site- and stage-specific expression of SATB2 in the developing palate. Despite the strong evidence supporting an important role for SATB2 in palate development, mutation analysis of 70 unrelated patients with CPO did not reveal any coding region variants. PMID:12915443

  2. Connection preserving deformations and q-semi-classical orthogonal polynomials

    NASA Astrophysics Data System (ADS)

    Ormerod, Christopher M.; Witte, N. S.; Forrester, Peter J.

    2011-09-01

    We present a framework for the study of q-difference equations satisfied by q-semi-classical orthogonal systems. As an example, we identify the q-difference equation satisfied by a deformed version of the little q-Jacobi polynomials as a gauge transformation of a special case of the associated linear problem for q-PVI. We obtain a parametrization of the associated linear problem in terms of orthogonal polynomial variables and find the relation between this parametrization and that of Jimbo and Sakai.

  3. Circuit Stops Prelasing In A Q-Switched Laser

    NASA Technical Reports Server (NTRS)

    Lockard, George E.

    1995-01-01

    Protective shutdown circuit stops prelasing in Q-switched laser operating at pulse-repetition rate of about 10 Hz. During normal operation, Q-switch prevents emission of light from laser cavity during application of Q-switch-trigger pulse. When circuit detects prelasing, it triggers relay turning off laser power supply. Circuit integrated into almost any Q-switched-laser system, provided one gains access to laser light, Q-switch-trigger pulse, and safety-interlock line of laser power supply.

  4. Extended ultrahigh-Q-cavity diode laser.

    PubMed

    Xie, Zhenda; Liang, Wei; Savchenkov, Anatoliy A; Lim, Jinkang; Burkhart, Jan; McDonald, Mickey; Zelevinsky, Tanya; Ilchenko, Vladimir S; Matsko, Andrey B; Maleki, Lute; Wong, Chee Wei

    2015-06-01

    We report on a study of a 698 nm extended cavity semiconductor laser with intracavity narrowband optical feedback from a whispering gallery mode resonator. This laser comprises an ultrahigh-Q (>10(10)) resonator supporting stimulated Rayleigh scattering, a diffraction grating wavelength preselector, and a reflective semiconductor amplifier. Single longitudinal mode lasing is characterized with sub-kilohertz linewidth and a 9 nm coarse tuning range. The laser has a potential application for integration with the 1S0-3P0 strontium transition to create compact precision atomic clocks. PMID:26030566

  5. Spatial filter for Q-switched lasers

    NASA Technical Reports Server (NTRS)

    Wuerker, R. F.; Heflinger, L. O. (Inventor)

    1977-01-01

    A spatial filtered Q-switched laser system is reported that prevents ionization of air in close proximity to the aperture of the spatial filter. A compound lens system having an astigmatic focus is positioned between the laser and the spatial filter for defocusing the light beam emanating from the laser in the vicinity of the aperture of the spatial filter to an intensity below that which produces ionization of air. The preferred construction of the compound lens system as viewed from the laser comprises a cylindrical lens and a pair of positive lenses.

  6. Rheumatoid arthritis association at 6q23.

    PubMed

    Thomson, Wendy; Barton, Anne; Ke, Xiayi; Eyre, Steve; Hinks, Anne; Bowes, John; Donn, Rachelle; Symmons, Deborah; Hider, Samantha; Bruce, Ian N; Wilson, Anthony G; Marinou, Ioanna; Morgan, Ann; Emery, Paul; Carter, Angela; Steer, Sophia; Hocking, Lynne; Reid, David M; Wordsworth, Paul; Harrison, Pille; Strachan, David; Worthington, Jane

    2007-12-01

    The Wellcome Trust Case Control Consortium (WTCCC) identified nine single SNPs putatively associated with rheumatoid arthritis at P = 1 x 10(-5) - 5 x 10(-7) in a genome-wide association screen. One, rs6920220, was unequivocally replicated (trend P = 1.1 x 10(-8)) in a validation study, as described here. This SNP maps to 6q23, between the genes oligodendrocyte lineage transcription factor 3 (OLIG3) and tumor necrosis factor-alpha-induced protein 3 (TNFAIP3). PMID:17982455

  7. Overview of LANL and ESH&Q

    SciTech Connect

    Dutro, Cynthia L

    2011-01-13

    ESH&Q FY11 objectives are to: (1) Clearly define the ESH&O standards and requirements for institutional programs to ensure compliance with contractual and regulatory requirements, and communicate the relevant requirements, including specific work activities and associated priorities that must be completed, to LANL Organizations; (2) Provide qualified ESH&O subject matter expertise, training support, centralized and deployed services, tools, and procedures to meet both internal customer needs and institutional operational requirements, subject to institutional funding; and (3) Provide support to the Laboratory to meet operational commitments and performance goals.

  8. Noncommutative q -photon-added coherent states

    NASA Astrophysics Data System (ADS)

    Dey, Sanjib; Hussin, Véronique

    2016-05-01

    We construct the photon-added coherent states of a noncommutative harmonic oscillator associated to a q -deformed oscillator algebra. Various nonclassical properties of the corresponding system are explored, first, by studying two different types of higher-order quadrature squeezing, namely, the Hillery type and the Hong-Mandel type, and second, by testing the sub-Poissonian nature of photon statistics in higher order with the help of the correlation function and the Mandel parameter. Also, we compare the behavior of different types of quadrature and photon number squeezing of our system with those of the ordinary harmonic oscillator by considering the same set of parameters.

  9. Back to 1974: The Q-onium

    NASA Astrophysics Data System (ADS)

    Kamenik, Jernej F.; Redi, Michele

    2016-09-01

    We show that the 750 GeV di-photon excess could be explained by the Q-onium system of a new QCD-like theory with fermions vectorial under the SM. Beside the spin-0 di-photon singlet this scenario predicts almost degenerate colored scalars and spin-1 resonances analogous to the J / Ψ in QCD. All these states are within the reach of the LHC. An apparent large width can be explained as due to production of excited states with splitting Δm ∼ Γ.

  10. Rheumatoid arthritis susceptibility loci at chromosomes 10p15, 12q13 and 22q13.

    PubMed

    Barton, Anne; Thomson, Wendy; Ke, Xiayi; Eyre, Steve; Hinks, Anne; Bowes, John; Plant, Darren; Gibbons, Laura J; Wilson, Anthony G; Bax, Deborah E; Morgan, Ann W; Emery, Paul; Steer, Sophia; Hocking, Lynne; Reid, David M; Wordsworth, Paul; Harrison, Pille; Worthington, Jane

    2008-10-01

    The WTCCC study identified 49 SNPs putatively associated with rheumatoid arthritis at P = 1 x 10(-4) - 1 x 10(-5) (tier 3). Here we show that three of these SNPs, mapping to chromosome 10p15 (rs4750316), 12q13 (rs1678542) and 22q13 (rs3218253), are also associated (trend P = 4 x 10(-5), P = 4 x 10(-4) and P = 4 x 10(-4), respectively) in a validation study of 4,106 individuals with rheumatoid arthritis and an expanded reference group of 11,238 subjects, confirming them as true susceptibility loci in individuals of European ancestry. PMID:18794857

  11. The real-virtual antenna functions for S → Q Q bar X at NNLO QCD

    NASA Astrophysics Data System (ADS)

    Dekkers, Oliver; Bernreuther, Werner

    2014-11-01

    We determine, in the antenna subtraction framework for handling infrared divergences in higher order QCD calculations, the real-virtual antenna functions for processes involving the production of a pair of massive quarks by an uncolored initial state at NNLO QCD. The integrated leading and subleading color real-virtual antenna functions are computed analytically in terms of (cyclotomic) harmonic polylogarithms. As a by-product and check we compute RQ = σ (e+e- →γ* → Q Q bar X) / σ (e+e- →γ* →μ+μ-) and compare with existing results. Our result for RQ is exact to order αs2.

  12. Automobile maneuvering device

    SciTech Connect

    Ricciardi, R.

    1987-08-18

    An automobile maneuvering device is described which consists of: a chassis comprising transport wheels for permitting movement of the device along the ground, a drive wheel operably rotatably connected to the chassis, and means for rotating the drive wheel, clamp means operably connected to the chassis and spaced from and opposed to the drive wheel, the chassis including means to move the clamp means to engage one portion of an automobile tire with the drive wheel engaged at another portion of the automobile tire, and means to actuate the rotating means, so that with rotation of the drive wheel the automobile tire is rotated and the automobile and device moved along the ground.

  13. Contamination sampling device

    NASA Technical Reports Server (NTRS)

    Delgado, Felix A. (Inventor); Stern, Susan M. (Inventor)

    1998-01-01

    A contamination sample collection device has a wooden dowel with a cotton swab at one end, the cotton being covered by a nylon cloth and the wooden dowel being encapsulated by plastic tubing which is heat shrunk onto the dowel and onto a portion of the cotton swab to secure the cotton in place. Another plastic tube is heat shrunk onto the plastic that encapsulates the dowel and a portion of the nylon cloth to secure the nylon cloth in place. The device may thereafter be covered with aluminum foil protector. The device may be used for obtaining samples of contamination in clean room environments.

  14. INTERNAL CUTTING DEVICE

    DOEpatents

    Russell, W.H. Jr.

    1959-06-30

    A device is described for removing material from the interior of a hollow workpiece so as to form a true spherical internal surface in a workpiece, or to cut radial slots of an adjustable constant depth in an already established spherical internal surface. This is accomplished by a spring loaded cutting tool adapted to move axially wherein the entire force urging the tool against the workpiece is derived from the spring. Further features of importance involve the provision of a seal between the workpiece and the cutting device and a suction device for carrying away particles of removed material.

  15. Rain sampling device

    DOEpatents

    Nelson, Danny A.; Tomich, Stanley D.; Glover, Donald W.; Allen, Errol V.; Hales, Jeremy M.; Dana, Marshall T.

    1991-01-01

    The present invention constitutes a rain sampling device adapted for independent operation at locations remote from the user which allows rainfall to be sampled in accordance with any schedule desired by the user. The rain sampling device includes a mechanism for directing wet precipitation into a chamber, a chamber for temporarily holding the precipitation during the process of collection, a valve mechanism for controllably releasing samples of said precipitation from said chamber, a means for distributing the samples released from the holding chamber into vessels adapted for permanently retaining these samples, and an electrical mechanism for regulating the operation of the device.

  16. Rain sampling device

    DOEpatents

    Nelson, D.A.; Tomich, S.D.; Glover, D.W.; Allen, E.V.; Hales, J.M.; Dana, M.T.

    1991-05-14

    The present invention constitutes a rain sampling device adapted for independent operation at locations remote from the user which allows rainfall to be sampled in accordance with any schedule desired by the user. The rain sampling device includes a mechanism for directing wet precipitation into a chamber, a chamber for temporarily holding the precipitation during the process of collection, a valve mechanism for controllably releasing samples of the precipitation from the chamber, a means for distributing the samples released from the holding chamber into vessels adapted for permanently retaining these samples, and an electrical mechanism for regulating the operation of the device. 11 figures.

  17. Corrosion Detection Devices

    SciTech Connect

    Howard, B.

    2003-12-01

    Nondestructive Examination Systems' (NDE) specialists at the Department of Energy's Savannah River Site have unique, remotely controllable, corrosion detection capabilities. The corrosion detection devices most frequently used are automated ultrasonic mapping systems, digital radiography imaging devices, infrared imaging, and eddy current mapping systems. These devices have been successfully used in a variety of applications, some of which involve high levels of background radiation. Not only is corrosion located and mapped but other types of anomalies such as cracks have been detected and characterized. Examples of actual corrosion that has been detected will be discussed along with the NDE systems that were used.

  18. SLUG HANDLING DEVICES

    DOEpatents

    Gentry, J.R.

    1958-09-16

    A device is described for handling fuel elements of a neutronic reactor. The device consists of two concentric telescoped contalners that may fit about the fuel element. A number of ratchet members, equally spaced about the entrance to the containers, are pivoted on the inner container and spring biased to the outer container so thnt they are forced to hear against and hold the fuel element, the weight of which tends to force the ratchets tighter against the fuel element. The ratchets are released from their hold by raising the inner container relative to the outer memeber. This device reduces the radiation hazard to the personnel handling the fuel elements.

  19. Corneal seal device

    NASA Technical Reports Server (NTRS)

    Baehr, E. F. (Inventor)

    1977-01-01

    A corneal seal device is provided which, when placed in an incision in the eye, permits the insertion of a surgical tool or instrument through the device into the eye. The device includes a seal chamber which opens into a tube which is adapted to be sutured to the eye and serves as an entry passage for a tool. A sealable aperture in the chamber permits passage of the tool through the chamber into the tube and hence into the eye. The chamber includes inlet ports adapted to be connected to a regulated source of irrigation fluid which provides a safe intraocular pressure.

  20. Problems with the linear q-Fokker Planck equation

    NASA Astrophysics Data System (ADS)

    Yano, Ryosuke

    2015-05-01

    In this letter, we discuss the linear q-Fokker Planck equation, whose solution follows Tsallis distribution, from the viewpoint of kinetic theory. Using normal definitions of moments, we can expand the distribution function with infinite moments for 0 ⩽ q < 1, whereas we cannot expand the distribution function with infinite moments for 1 < q owing to emergences of characteristic points in moments. From Grad's 13 moment equations for the linear q-Fokker Planck equation, the dissipation rate of the heat flux via the linear q-Fokker Planck equation diverges at 0 ⩽ q < 2/3. In other words, the thermal conductivity, which defines the heat flux with the spatial gradient of the temperature and the thermal conductivity, which defines the heat flux with the spacial gradient of the density, jumps to zero at q = 2/3, discontinuously.

  1. Internal friction Q factor measurements in lunar rocks

    NASA Technical Reports Server (NTRS)

    Tittmann, B. R.

    1978-01-01

    In order to better interpret recently reported values for the variation of seismic Q as a function of depth below the lunar surface, we have developed apparatus and made laboratory measurements of Q as a function of hydrostatic pressure, temperature and frequency. Our measurements of the Q associated with shear deformations have demonstrated that the large difference in Q between well outgassed and volatile rich rocks persists to pressures corresponding to a depth of at least 50 km. Here we report new measurements of Q as a function of temperature, on the development of techniques to measure the Q associated with extensional deformations under hydrostatic pressure, on the derivation of theoretical relations between our laboratory Q values and the attenuation coefficient of seismic waves, and on the development of a model for mechanism of adsorption.

  2. Molecular dissection of the 5q deletion in myelodysplastic syndrome

    PubMed Central

    Ebert, Benjamin L.

    2011-01-01

    The 5q- syndrome is a subtype of myelodysplastic syndrome (MDS) with a defined clinical phenotype associated with heterozygous deletions of Chromosome 5q. While no genes have been identified that undergo recurrent homozygous inactivation, functional studies have revealed individual genes that contribute to the clinical phenotype of MDS through haploinsufficient gene expression. Heterozygous loss of the RPS14 gene on 5q leads to activation of p53 in the erythroid lineage and the macrocytic anemia characteristic of the 5q- syndrome. The megakaryocytic and platelet phenotype of the 5q- syndrome has been attributed to heterozygous deletion of miR145 and miR146a. Murine models have implicated heterozygous loss of APC, EGR1, DIAPH1, and NPM1 in the pathophysiology of del(5q) MDS. These findings indicate that the phenotype of MDS patients with deletions of Chromosome 5q is due to haploinsufficiency of multiple genes. PMID:21943668

  3. Method and device for stand-off laser drilling and cutting

    DOEpatents

    Copley, John A.; Kwok, Hoi S.; Domankevitz, Yacov

    1989-09-26

    A device for perforating material and a method of stand-off drilling using a laser. In its basic form a free-running laser beam creates a melt on the target and then a Q-switched short duration pulse is used to remove the material through the creation of a laser detonation wave. The advantage is a drilling/cutting method capable of working a target at lengthy stand-off distance. The device may employ 2 lasers or a single one operated in a free-running/Q-switched dual mode.

  4. Interaction between complement subcomponent C1q and bacterial lipopolysaccharides.

    PubMed

    Zohair, A; Chesne, S; Wade, R H; Colomb, M G

    1989-02-01

    The heptose-less mutant of Escherichia coli, D31m4, bound complement subcomponent C1q and its collagen-like fragments (C1qCLF) with Ka values of 1.4 x 10(8) and 2.0 x 10(8) M-1 respectively. This binding was suppressed by chemical modification of C1q and C1qCLF using diethyl pyrocarbonate (DEPC). To investigate the role of lipopolysaccharides (LPS) in this binding, biosynthetically labelled [14C]LPS were purified from E. coli D31m4 and incorporated into liposomes prepared from phosphatidylcholine (PC) and phosphatidylethanolamine (PE) [PC/PE/LPS, 2:2:1, by wt.]. Binding of C1q or its collagen-like fragments to the liposomes was estimated via a flotation test. These liposomes bound C1q and C1qCLF with Ka values of 8.0 x 10(7) and 2.0 x 10(7) M-1; this binding was totally inhibited after chemical modification of C1q and C1qCLF by DEPC. Liposomes containing LPS purified from the wild-strain E. coli K-12 S also bound C1q and C1qCLF, whereas direct binding of C1q or C1qCLF to the bacteria was negligible. Diamines at concentrations which dissociate C1 into C1q and (C1r, C1s)2, strongly inhibited the interaction of C1q or C1qCLF with LPS. Removal of 3-deoxy-D-manno-octulosonic acid (2-keto-3-deoxyoctonic acid; KDO) from E. coli D31m4 LPS decreases the binding of C1qCLF to the bacteria by 65%. When this purified and modified LPS was incorporated into liposomes, the C1qCLF binding was completely abolished. These results show: (i) the essential role of the collagen-like moiety and probably its histidine residues in the interaction between C1q and the mutant D31m4; (ii) the contribution of LPS, particularly the anionic charges of KDO, to this interaction. PMID:2649081

  5. Passive Q-switching of an all-fiber laser induced by the Kerr effect of multimode interference.

    PubMed

    Fu, Shijie; Sheng, Quan; Zhu, Xiushan; Shi, Wei; Yao, Jianquan; Shi, Guannan; Norwood, R A; Peyghambarian, N

    2015-06-29

    A novel passively Q-switched all-fiber laser using a single mode-multimode-single mode fiber device as the saturable absorber based on the Kerr effect of multimode interference is reported. Stable Q-switched operation of an Er(3+)/Yb(3+) co-doped fiber laser at 1559.5 nm was obtained at a pump power range of 190-510 mW with the repetition rate varying from 14.1 kHz to 35.2 kHz and the pulse duration ranging from 5.69 μs to 3.86 μs. A maximum pulse energy of 0.8 μJ at an average output power of 27.6 mW was achieved. This demonstrates a new modulation mechanism for realizing Q-switched all-fiber laser sources. PMID:26191734

  6. Large repetitively Q-switched oscillators

    NASA Astrophysics Data System (ADS)

    Epstein, H. M.; Dulaney, J. L.; O'Loughlin, J. F.; Altman, W. P.

    A versatile waveform laser which can operate in bursts from 5 to 160 ms long and deliver up to 30 kJ power burst has been constructed. This Nd:glass laser system consists of four oscillators in parallel. Each oscillator can be varied in length from about 3 to 10 m, and contains two pump heads 670 mm long by 64 mm in diameter phosphate glass laser rods. When trains of Q-switched pulses are required, 70 mm diameter Pockels cells and dielectric polarizers are added to the oscillator cavity. The basic burst duration of 5 ms can be stretched to 10, 20, 40, 80,and 160 ms by sequencing the firing of flashlamps, with the longest pulse length attained by sequentially firing 1/4 heads. Trains of Q-switched pulses up to 10 kHz in repetition rate and 50 to 900 ns wide can be obtained by varying the cavity configuration and Pockels cell firing rate. Spatial distributions are flat-topped within about 10 percent. Overall efficiency for the oscillator with a CW waveform can exceed 4.8 percent.

  7. HST Spectroscopy of Q0302-003

    NASA Astrophysics Data System (ADS)

    Heap, S. R.

    1996-05-01

    The flux of a quasar shortward of the rest-frame wavelength of He\\sc ii Ly alpha (304 Angstroms) should be depressed due to absorption by He(+) ions in the diffuse intergalactic medium (the Gunn-Peterson effect) and/or absorption by He(+) ions residing in clumps or clouds that make up the Ly alpha forest. Such absorption was recently detected in a FOC spectrum of the z=3.286 quasar, Q0302-003, by Jakobsen et al. (Nature 370, 35, 1994), but the spectral resolution of the FOC was not sufficient to show whether the absorption is produced by a uniformly distributed medium or by a forest of Ly alpha lines. Last year, Songaila, Hu & Cowie (Nature 375, 124, 1995) used the HIRES echelle spectrograph on Keck to obtain a high-quality spectrum of the H \\sc i Lyalpha forest of Q0302-003. They detected a multitude of Lyalpha - forest clouds, some with column densities as low as 2* 10(12) cm(-2) . They argued that absorption in these clouds is sufficient to account for the observed absorption. This quasar has now been observed by the Goddard High Resolution Spectrograph (GHRS) at 0.6 Angstroms resolution, and it is a planned target of observation by the Space Telescope Imaging Spectrograph (STIS), an instrument scheduled to be installed on HST in February 1997. In this paper, we describe the findings from the GHRS observations and evaluate the prospects for future STIS observations.

  8. Nonlinear q -voter model with inflexible zealots

    NASA Astrophysics Data System (ADS)

    Mobilia, Mauro

    2015-07-01

    We study the dynamics of the nonlinear q -voter model with inflexible zealots in a finite well-mixed population. In this system, each individual supports one of two parties and is either a susceptible voter or an inflexible zealot. At each time step, a susceptible adopts the opinion of a neighbor if this belongs to a group of q ≥2 neighbors all in the same state, whereas inflexible zealots never change their opinion. In the presence of zealots of both parties, the model is characterized by a fluctuating stationary state and, below a zealotry density threshold, the distribution of opinions is bimodal. After a characteristic time, most susceptibles become supporters of the party having more zealots and the opinion distribution is asymmetric. When the number of zealots of both parties is the same, the opinion distribution is symmetric and, in the long run, susceptibles endlessly swing from the state where they all support one party to the opposite state. Above the zealotry density threshold, when there is an unequal number of zealots of each type, the probability distribution is single-peaked and non-Gaussian. These properties are investigated analytically and with stochastic simulations. We also study the mean time to reach a consensus when zealots support only one party.

  9. Q fever in domestic and wild birds.

    PubMed

    RASKA, K; SYRUCEK, L

    1956-01-01

    The authors report on the results of several years' research into the role of domestic and wild birds in the epidemiology and epizootiology of Q fever in Czechoslovakia. They examined 572 blood specimens taken from domestic birds in an area of endemic Q fever and found positive reactions to the complement-fixation test in hens, turkeys, ducks, geese, and pigeons, with hens showing the highest percentage of positive reactions. In addition, the susceptibility of hens to infection with Rickettsia burnetii was demonstrated experimentally, and excretion of R. burnetii in the stools of hens was demonstrated from the 7th to the 40th day after infection.Complement-fixation tests were also done on 480 blood specimens from wild birds with positive serological reactions in 15.8% of birds living directly on infected farms, 4.3% of birds living in the immediate vicinity of those farms, and 1.8% of birds living independently of human habitations but in an endemic area. R. burnetii was isolated from the spleen and liver of the redstart and the white wagtail and from ectoparasites of swallows. PMID:13383368

  10. Clinical relevance of 8q23, 15q13 and 18q21 SNP genotyping to evaluate colorectal cancer risk

    PubMed Central

    Baert-Desurmont, Stéphanie; Charbonnier, Françoise; Houivet, Estelle; Ippolito, Lorena; Mauillon, Jacques; Bougeard, Marion; Abadie, Caroline; Malka, David; Duffour, Jacqueline; Desseigne, Françoise; Colas, Chrystelle; Pujol, Pascal; Lejeune, Sophie; Dugast, Catherine; Buecher, Bruno; Faivre, Laurence; Leroux, Dominique; Gesta, Paul; Coupier, Isabelle; Guimbaud, Rosine; Berthet, Pascaline; Manouvrier, Sylvie; Cauchin, Estelle; Prieur, Fabienne; Laurent-Puig, Pierre; Lebrun, Marine; Jonveaux, Philippe; Chiesa, Jean; Caron, Olivier; Morin-Meschin, Marie-Emmanuelle; Polycarpe-Osaer, Florence; Giraud, Sophie; Zaanan, Aziz; Bonnet, Delphine; Mansuy, Ludovic; Bonadona, Valérie; El Chehadeh, Salima; Duhoux, François; Gauthier-Villars, Marion; Saurin, Jean-Christophe; Collonge-Rame, Marie- Agnès; Brugières, Laurence; Wang, Qing; Bressac-de Paillerets, Brigitte; Rey, Jean-Marc; Toulas, Christine; Buisine, Marie-Pierre; Bronner, Myriam; Sokolowska, Joanna; Hardouin, Agnès; Cailleux, Anne-Françoise; Sebaoui, Hakim; Blot, Julien; Tinat, Julie; Benichou, Jacques; Frebourg, Thierry

    2016-01-01

    To determine if the at-risk single-nucleotide polymorphism (SNP) alleles for colorectal cancer (CRC) could contribute to clinical situations suggestive of an increased genetic risk for CRC, we performed a prospective national case–control study based on highly selected patients (CRC in two first-degree relatives, one before 61 years of age; or CRC diagnosed before 51 years of age; or multiple primary CRCs, the first before 61 years of age; exclusion of Lynch syndrome and polyposes) and controls without personal or familial history of CRC. SNPs were genotyped using SNaPshot, and statistical analyses were performed using Pearson's χ2 test, Cochran–Armitage test of trend and logistic regression. We included 1029 patients and 350 controls. We confirmed the association of CRC risk with four SNPs, with odds ratio (OR) higher than previously reported: rs16892766 on 8q23.3 (OR: 1.88, 95% confidence interval (CI): 1.30–2.72; P=0.0007); rs4779584 on 15q13.3 (OR: 1.42, CI: 1.11–1.83; P=0.0061) and rs4939827 and rs58920878/Novel 1 on 18q21.1 (OR: 1.49, CI: 1.13–1.98; P=0.007 and OR: 1.49, CI: 1.14–1.95; P=0.0035). We found a significant (P<0.0001) cumulative effect of the at-risk alleles or genotypes with OR at 1.62 (CI: 1.10–2.37), 2.09 (CI: 1.43–3.07), 2.87 (CI: 1.76–4.70) and 3.88 (CI: 1.72–8.76) for 1, 2, 3 and at least 4 at-risk alleles, respectively, and OR at 1.71 (CI: 1.18–2.46), 2.29 (CI: 1.55–3.38) and 6.21 (CI: 2.67–14.42) for 1, 2 and 3 at-risk genotypes, respectively. Combination of SNPs may therefore explain a fraction of clinical situations suggestive of an increased risk for CRC. PMID:25873010

  11. Clinical relevance of 8q23, 15q13 and 18q21 SNP genotyping to evaluate colorectal cancer risk.

    PubMed

    Baert-Desurmont, Stéphanie; Charbonnier, Françoise; Houivet, Estelle; Ippolito, Lorena; Mauillon, Jacques; Bougeard, Marion; Abadie, Caroline; Malka, David; Duffour, Jacqueline; Desseigne, Françoise; Colas, Chrystelle; Pujol, Pascal; Lejeune, Sophie; Dugast, Catherine; Buecher, Bruno; Faivre, Laurence; Leroux, Dominique; Gesta, Paul; Coupier, Isabelle; Guimbaud, Rosine; Berthet, Pascaline; Manouvrier, Sylvie; Cauchin, Estelle; Prieur, Fabienne; Laurent-Puig, Pierre; Lebrun, Marine; Jonveaux, Philippe; Chiesa, Jean; Caron, Olivier; Morin-Meschin, Marie-Emmanuelle; Polycarpe-Osaer, Florence; Giraud, Sophie; Zaanan, Aziz; Bonnet, Delphine; Mansuy, Ludovic; Bonadona, Valérie; El Chehadeh, Salima; Duhoux, François; Gauthier-Villars, Marion; Saurin, Jean-Christophe; Collonge-Rame, Marie-Agnès; Brugières, Laurence; Wang, Qing; Bressac-de Paillerets, Brigitte; Rey, Jean-Marc; Toulas, Christine; Buisine, Marie-Pierre; Bronner, Myriam; Sokolowska, Joanna; Hardouin, Agnès; Cailleux, Anne-Françoise; Sebaoui, Hakim; Blot, Julien; Tinat, Julie; Benichou, Jacques; Frebourg, Thierry

    2016-01-01

    To determine if the at-risk single-nucleotide polymorphism (SNP) alleles for colorectal cancer (CRC) could contribute to clinical situations suggestive of an increased genetic risk for CRC, we performed a prospective national case-control study based on highly selected patients (CRC in two first-degree relatives, one before 61 years of age; or CRC diagnosed before 51 years of age; or multiple primary CRCs, the first before 61 years of age; exclusion of Lynch syndrome and polyposes) and controls without personal or familial history of CRC. SNPs were genotyped using SNaPshot, and statistical analyses were performed using Pearson's χ(2) test, Cochran-Armitage test of trend and logistic regression. We included 1029 patients and 350 controls. We confirmed the association of CRC risk with four SNPs, with odds ratio (OR) higher than previously reported: rs16892766 on 8q23.3 (OR: 1.88, 95% confidence interval (CI): 1.30-2.72; P=0.0007); rs4779584 on 15q13.3 (OR: 1.42, CI: 1.11-1.83; P=0.0061) and rs4939827 and rs58920878/Novel 1 on 18q21.1 (OR: 1.49, CI: 1.13-1.98; P=0.007 and OR: 1.49, CI: 1.14-1.95; P=0.0035). We found a significant (P<0.0001) cumulative effect of the at-risk alleles or genotypes with OR at 1.62 (CI: 1.10-2.37), 2.09 (CI: 1.43-3.07), 2.87 (CI: 1.76-4.70) and 3.88 (CI: 1.72-8.76) for 1, 2, 3 and at least 4 at-risk alleles, respectively, and OR at 1.71 (CI: 1.18-2.46), 2.29 (CI: 1.55-3.38) and 6.21 (CI: 2.67-14.42) for 1, 2 and 3 at-risk genotypes, respectively. Combination of SNPs may therefore explain a fraction of clinical situations suggestive of an increased risk for CRC. PMID:25873010

  12. Geometry and Cloaking Devices

    NASA Astrophysics Data System (ADS)

    Ochiai, T.; Nacher, J. C.

    2011-09-01

    Recently, the application of geometry and conformal mappings to artificial materials (metamaterials) has attracted the attention in various research communities. These materials, characterized by a unique man-made structure, have unusual optical properties, which materials found in nature do not exhibit. By applying the geometry and conformal mappings theory to metamaterial science, it may be possible to realize so-called "Harry Potter cloaking device". Although such a device is still in the science fiction realm, several works have shown that by using such metamaterials it may be possible to control the direction of the electromagnetic field at will. We could then make an object hidden inside of a cloaking device. Here, we will explain how to design invisibility device using differential geometry and conformal mappings.

  13. Devices for Arrhythmia

    MedlinePlus

    ... the heart an electric shock (as with a defibrillator ). For people with recurrent arrhythmias, medical devices such as a pacemaker and implantable cardioverter defibrillator (ICD) can help by continuously monitoring the heart's ...

  14. Devices for hearing loss

    MedlinePlus

    ... bring the sound from your TV, radio, or music player directly to your inner ear. Many listening devices now work through a wireless link and can connect directly to your hearing aid. There is also television closed-captioning, which ...

  15. Optical devices: A compilation

    NASA Technical Reports Server (NTRS)

    1976-01-01

    Technological developments in the field of optics devices which have potential utility outside the aerospace community are described. Optical instrumentation, light generation and transmission, and laser techniques are among the topics covered. Patent information is given.

  16. Adhesion testing device

    NASA Technical Reports Server (NTRS)

    LaPeyronnie, Glenn M. (Inventor); Huff, Charles M. (Inventor)

    2010-01-01

    The present invention provides a testing apparatus and method for testing the adhesion of a coating to a surface. The invention also includes an improved testing button or dolly for use with the testing apparatus and a self aligning button hook or dolly interface on the testing apparatus. According to preferred forms, the apparatus and method of the present invention are simple, portable, battery operated rugged, and inexpensive to manufacture and use, are readily adaptable to a wide variety of uses, and provide effective and accurate testing results. The device includes a linear actuator driven by an electric motor coupled to the actuator through a gearbox and a rotatable shaft. The electronics for the device are contained in the head section of the device. At the contact end of the device, is positioned a self aligning button hook, attached below the load cell located on the actuator shaft.

  17. Anaerobic specimen transport device.

    PubMed Central

    Wilkins, T D; Jimenez-Ulate, F

    1975-01-01

    A device is described and evaluated for the anaerobic transport of clinical specimens. The device limits the amount of oxygen entering with the sample to a maximum of 2%, which is rapidly removed by reacting with hydrogen in the presence of a palladium catalyst. The viability on swabs of 12 species of anaerobes, four strains of facultative anaerobes and a strain of Pseudomonas aeruginosa, was maintained during the length of the tests (24 or 48 h). The results demonstrated that this device protected even the more oxygen-sensitive clinical anaerobes from death due to oxygen exposure. This device can be used for swabs as well as for anaerobic collection and liquid and solid specimens. Images PMID:1104656

  18. Supraglottic airway devices.

    PubMed

    Ramachandran, Satya Krishna; Kumar, Anjana M

    2014-06-01

    Supraglottic airway devices (SADs) are used to keep the upper airway open to provide unobstructed ventilation. Early (first-generation) SADs rapidly replaced endotracheal intubation and face masks in > 40% of general anesthesia cases due to their versatility and ease of use. Second-generation devices have further improved efficacy and utility by incorporating design changes. Individual second-generation SADs have allowed more dependable positive-pressure ventilation, are made of disposable materials, have integrated bite blocks, are better able to act as conduits for tracheal tube placement, and have reduced risk of pulmonary aspiration of gastric contents. SADs now provide successful rescue ventilation in > 90% of patients in whom mask ventilation or tracheal intubation is found to be impossible. However, some concerns with these devices remain, including failing to adequately ventilate, causing airway damage, and increasing the likelihood of pulmonary aspiration of gastric contents. Careful patient selection and excellent technical skills are necessary for successful use of these devices. PMID:24891199

  19. Device control at CEBAF

    SciTech Connect

    Schaffner, S.; Barker, D.; Bookwalter, V.

    1996-08-01

    CEBAF has undergone a major conversion of its accelerator control system from TACL to EPICS, affecting device control for the RF system, magnets, the machine protection system, the vacuum and valves, and the diagnostic systems including beam position monitors, harps, and the camera and solenoid devices (beam viewers, faraday cups, optical transition radiation viewers, synchrotron radiation monitor, etc.). Altogether these devices require approximately 125,000 EPICS database records. The majority of these devices are controlled through CAMAC; some use embedded microprocessors (RF and magnets), and newer interfaces are in VME. The standard EPICS toolkit was extended to include a driver for CAMAC which supports dual processors on one serial highway, custom database records for magnets and BPMs, and custom data acquisition tasks for the BPMs. 2 refs., 1 tab.

  20. Water-walking devices

    NASA Astrophysics Data System (ADS)

    Hu, David L.; Prakash, Manu; Chan, Brian; Bush, John W. M.

    2007-11-01

    We report recent efforts in the design and construction of water-walking machines inspired by insects and spiders. The fundamental physical constraints on the size, proportion and dynamics of natural water-walkers are enumerated and used as design criteria for analogous mechanical devices. We report devices capable of rowing along the surface, leaping off the surface and climbing menisci by deforming the free surface. The most critical design constraint is that the devices be lightweight and non-wetting. Microscale manufacturing techniques and new man-made materials such as hydrophobic coatings and thermally actuated wires are implemented. Using high-speed cinematography and flow visualization, we compare the functionality and dynamics of our devices with those of their natural counterparts.

  1. Water-walking devices

    NASA Astrophysics Data System (ADS)

    Hu, David L.; Prakash, Manu; Chan, Brian; Bush, John W. M.

    We report recent efforts in the design and construction of water-walking machines inspired by insects and spiders. The fundamental physical constraints on the size, proportion and dynamics of natural water-walkers are enumerated and used as design criteria for analogous mechanical devices. We report devices capable of rowing along the surface, leaping off the surface and climbing menisci by deforming the free surface. The most critical design constraint is that the devices be lightweight and non-wetting. Microscale manufacturing techniques and new man-made materials such as hydrophobic coatings and thermally actuated wires are implemented. Using highspeed cinematography and flow visualization, we compare the functionality and dynamics of our devices with those of their natural counterparts.

  2. High temperature measuring device

    DOEpatents

    Tokarz, Richard D.

    1983-01-01

    A temperature measuring device for very high design temperatures (to 2,000.degree. C.). The device comprises a homogenous base structure preferably in the form of a sphere or cylinder. The base structure contains a large number of individual walled cells. The base structure has a decreasing coefficient of elasticity within the temperature range being monitored. A predetermined quantity of inert gas is confined within each cell. The cells are dimensionally stable at the normal working temperature of the device. Increases in gaseous pressure within the cells will permanently deform the cell walls at temperatures within the high temperature range to be measured. Such deformation can be correlated to temperature by calibrating similarly constructed devices under known time and temperature conditions.

  3. Microreactor array device.

    PubMed

    Wiktor, Peter; Brunner, Al; Kahn, Peter; Qiu, Ji; Magee, Mitch; Bian, Xiaofang; Karthikeyan, Kailash; LaBaer, Joshua

    2015-01-01

    We report a device to fill an array of small chemical reaction chambers (microreactors) with reagent and then seal them using pressurized viscous liquid acting through a flexible membrane. The device enables multiple, independent chemical reactions involving free floating intermediate molecules without interference from neighboring reactions or external environments. The device is validated by protein expressed in situ directly from DNA in a microarray of ~10,000 spots with no diffusion during three hours incubation. Using the device to probe for an autoantibody cancer biomarker in blood serum sample gave five times higher signal to background ratio compared to standard protein microarray expressed on a flat microscope slide. Physical design principles to effectively fill the array of microreactors with reagent and experimental results of alternate methods for sealing the microreactors are presented. PMID:25736721

  4. Microreactor Array Device

    PubMed Central

    Wiktor, Peter; Brunner, Al; Kahn, Peter; Qiu, Ji; Magee, Mitch; Bian, Xiaofang; Karthikeyan, Kailash; LaBaer, Joshua

    2015-01-01

    We report a device to fill an array of small chemical reaction chambers (microreactors) with reagent and then seal them using pressurized viscous liquid acting through a flexible membrane. The device enables multiple, independent chemical reactions involving free floating intermediate molecules without interference from neighboring reactions or external environments. The device is validated by protein expressed in situ directly from DNA in a microarray of ~10,000 spots with no diffusion during three hours incubation. Using the device to probe for an autoantibody cancer biomarker in blood serum sample gave five times higher signal to background ratio compared to standard protein microarray expressed on a flat microscope slide. Physical design principles to effectively fill the array of microreactors with reagent and experimental results of alternate methods for sealing the microreactors are presented. PMID:25736721

  5. Development of electrochromic devices.

    PubMed

    Pawlicka, A

    2009-01-01

    Electrochromic devices (ECD) are systems of considerable commercial interest due to their controllable transmission, absorption and/or reflectance. For instance, these devices are mainly applied to glare attenuation in automobile rearview mirrors and also in some smart windows that can regulate the solar gains of buildings. Other possible applications of ECDs include solar cells, small- and large-area flat panel displays, and frozen food monitoring and document authentication also are of great interest. Over the past 20 years almost 1000 patents and 1500 papers in journals and proceedings have been published with the key words "electrochromic windows". Most of these documents report on materials for electrochromic devices and only some of them about complete electrochromic devices. This paper describes the first patents and some of the recent ones on ECDs, whose development is possible due to the advances in nanotechnology. PMID:19958283

  6. Advanced underwater lift device

    NASA Technical Reports Server (NTRS)

    Flanagan, David T.; Hopkins, Robert C.

    1993-01-01

    Flexible underwater lift devices ('lift bags') are used in underwater operations to provide buoyancy to submerged objects. Commercially available designs are heavy, bulky, and awkward to handle, and thus are limited in size and useful lifting capacity. An underwater lift device having less than 20 percent of the bulk and less than 10 percent of the weight of commercially available models was developed. The design features a dual membrane envelope, a nearly homogeneous envelope membrane stress distribution, and a minimum surface-to-volume ratio. A proof-of-concept model of 50 kg capacity was built and tested. Originally designed to provide buoyancy to mock-ups submerged in NASA's weightlessness simulators, the device may have application to water-landed spacecraft which must deploy flotation upon impact, and where launch weight and volume penalties are significant. The device may also be useful for the automated recovery of ocean floor probes or in marine salvage applications.

  7. Microreactor Array Device

    NASA Astrophysics Data System (ADS)

    Wiktor, Peter; Brunner, Al; Kahn, Peter; Qiu, Ji; Magee, Mitch; Bian, Xiaofang; Karthikeyan, Kailash; Labaer, Joshua

    2015-03-01

    We report a device to fill an array of small chemical reaction chambers (microreactors) with reagent and then seal them using pressurized viscous liquid acting through a flexible membrane. The device enables multiple, independent chemical reactions involving free floating intermediate molecules without interference from neighboring reactions or external environments. The device is validated by protein expressed in situ directly from DNA in a microarray of ~10,000 spots with no diffusion during three hours incubation. Using the device to probe for an autoantibody cancer biomarker in blood serum sample gave five times higher signal to background ratio compared to standard protein microarray expressed on a flat microscope slide. Physical design principles to effectively fill the array of microreactors with reagent and experimental results of alternate methods for sealing the microreactors are presented.

  8. Thermoelectric materials and devices

    NASA Technical Reports Server (NTRS)

    Park, Yeonjoon (Inventor); Choi, Sang H. (Inventor); King, Glen C. (Inventor); Elliott, James R. (Inventor); Talcott, Noel A. (Inventor)

    2011-01-01

    New thermoelectric materials comprise highly [111]-oriented twinned group IV alloys on the basal plane of trigonal substrates, which exhibit a high thermoelectric figure of merit and good material performance, and devices made with these materials.

  9. Left ventricular restoration devices.

    PubMed

    Oliveira, Guilherme H; Al-Kindi, Sadeer G; Bezerra, Hiram G; Costa, Marco A

    2014-04-01

    Left ventricular (LV) remodeling results in continuous cardiac chamber enlargement and contractile dysfunction, perpetuating the syndrome of heart failure. With current exhaustion of the neurohormonal medical paradigm, surgical and device-based therapies have been increasingly investigated as a way to restore LV chamber architecture and function. Left ventricular restoration has been attempted with surgical procedures, such as partial left ventriculectomy, surgical ventricular restoration with or without revascularization, and devices, such as the Acorn CorCap, the Paracor HeartNet, and the Myocor Myosplint. Whereas all these techniques require surgical access, with or without cardiopulmonary bypass, a newer ventricular partitioning device (VPD) called Parachute, can be delivered percutaneously through the aortic valve. Designed to achieve LV restoration from within the ventricle, this VPD partitions the LV by isolating aneurysmal from normal myocardium thereby diminishing the functioning cavity. This review aims to critically appraise the above methods, with particular attention to device-based therapies. PMID:24574107

  10. [Implantable medical devices].

    PubMed

    Crickx, B; Arrault, X

    2008-01-01

    Medical devices have been individualized to include a category of implantable medical devices, "designed to be totally implanted in the human body or to replace an epithelial surface or a surface of the eye, through surgery, and remain in place after the intervention" (directive 93/42/CEE and decree of 20 April 206). Each implantable medical device has a common name and a commercial name for precise identification of the model (type/references). The users' service and the implanting physician should be clearly identified. There are a number of rules concerning health traceability to rapidly identify patients exposed to risks in which the implantable medical devices of a particular batch or series were used and to monitor the consequences. The traceability data should be preserved 10 years and the patient's medical file for 20 years. PMID:18442666

  11. Q-Burst Origins in Africa

    NASA Astrophysics Data System (ADS)

    Boldi, R.; Hobara, Y.; Yamashita, K.; Hayakawa, M.; Satori, G.; Bor, J.; Lyons, W. A.; Nelson, T.; Russell, B.; Williams, E.

    2006-12-01

    The generation of electromagnetic transient signatures in the SR frequency range (Q-bursts) from the energetic lightning originating in Africa were intensively studied during the AMMA (African Monsoon Multidisciplinary Analysis) field program centered on Niamey, Niger in 2006. During this wet season many active westward- moving MCSs were observed by the MIT C-band Doppler radar. The MCSs exhibited a gust front, a leading squall line and a large spatially-extended (100-200 km) stratiform region that often passed over the observation site. Many transient events were recorded in association with local lightning both with a slow antenna and a DC electric field mill installed near the radar. During the gust front and squall line traverse, the majority of lightning exhibited normal polarity. A remarkable transition of polarity is observed once the radar site is under the stratiform region and a pronounced radar bright band has had time to develop. The majority of the ground flashes then exhibit a positive polarity (positive ground flash). In particular, very intense positive ground flashes (often topped with spider lightning structure) are registered when the radar "hbright band"h is most strongly developed. These positive flashes exhibit a large DC field change in comparison to ones observed during the earlier squall line passage. Video observations of nighttime events support the existence of the lateral extensive spider lightning. Daytime events exhibit thunder durations of a few minutes. ELF Q-bursts were recorded at MIT's Schumann resonance station in Rhode Island U.S.A. (about 8 Mm distance from Niamey) associated with several large well-established positive ground flashes observed locally near Niamey. The event identification is made by accurate GPS timing and arrival direction of the waves. The onset times of the Q-burst are in good agreement with the electric field measurement near Niamey. The arrival directions of the waves are also in good agreement assuming

  12. Burst-Disk Device Simulates Effect Of Pyrotechnic Device

    NASA Technical Reports Server (NTRS)

    Rogers, James P.; Sexton, James H.

    1995-01-01

    Expendable disks substituted for costly pyrotechnic devices for testing actuators. Burst-disk device produces rush of pressurized gas similar to pyrotechnic device. Designed to reduce cost of testing pyrotechnically driven emergency actuators (parachute-deploying mechanisms in original application).

  13. Nanowire Thermoelectric Devices

    NASA Technical Reports Server (NTRS)

    Borshchevsky, Alexander; Fleurial, Jean-Pierre; Herman, Jennifer; Ryan, Margaret

    2005-01-01

    Nanowire thermoelectric devices, now under development, are intended to take miniaturization a step beyond the prior state of the art to exploit the potential advantages afforded by shrinking some device features to approximately molecular dimensions (of the order of 10 nm). The development of nanowire-based thermoelectric devices could lead to novel power-generating, cooling, and sensing devices that operate at relatively low currents and high voltages. Recent work on the theory of thermoelectric devices has led to the expectation that the performance of such a device could be enhanced if the diameter of the wires could be reduced to a point where quantum confinement effects increase charge-carrier mobility (thereby increasing the Seebeck coefficient) and reduce thermal conductivity. In addition, even in the absence of these effects, the large aspect ratios (length of the order of tens of microns diameter of the order of tens of nanometers) of nanowires would be conducive to the maintenance of large temperature differences at small heat fluxes. The predicted net effect of reducing diameters to the order of tens of nanometers would be to increase its efficiency by a factor of .3. Nanowires made of thermoelectric materials and devices that comprise arrays of such nanowires can be fabricated by electrochemical growth of the thermoelectric materials in templates that contain suitably dimensioned pores (10 to 100 nm in diameter and 1 to 100 microns long). The nanowires can then be contacted in bundles to form devices that look similar to conventional thermoelectric devices, except that a production version may contain nearly a billion elements (wires) per square centimeter, instead of fewer than a hundred as in a conventional bulk thermoelectric device or fewer than 100,000 as in a microdevice. It is not yet possible to form contacts with individual nanowires. Therefore, in fabricating a nanowire thermoelectric device, one forms contacts on nanowires in bundles of the

  14. REACTOR CONTROL DEVICE

    DOEpatents

    Kaufman, H.B.; Weiss, A.A.

    1959-08-18

    A shadow control device for controlling a nuclear reactor is described. The device comprises a series of hollow neutron-absorbing elements arranged in groups, each element having a cavity for substantially housing an adjoining element and a longitudinal member for commonly supporting the groups of elements. Longitudinal actuation of the longitudinal member distributes the elements along its entire length in which position maximum worth is achieved.

  15. Exhaust gas purification device

    SciTech Connect

    Fujiwara, H.; Hibi, T.; Sayo, S.; Sugiura, Y.; Ueda, K.

    1980-02-19

    The exhaust gas purification device includes an exhaust manifold , a purification cylinder connected with the exhaust manifold through a first honey-comb shaped catalyst, and a second honeycomb shaped catalyst positioned at the rear portion of the purification cylinder. Each catalyst is supported by steel wool rings including coarse and dense portions of steel wool. The purification device further includes a secondary air supplying arrangement.

  16. Biomaterials and Biomedical Devices

    NASA Astrophysics Data System (ADS)

    Hanker, Jacob S.; Giammara, Beverly L.

    1988-11-01

    This review discusses the factors important in the incorporation or integration of biomaterials and devices by tissue. Methods for surface modification and surface-sensitive techniques for analysis are cited. In vitro methods to evaluate the biocompatibility or efficacy of certain biomaterials and devices are presented. Present and future directions in neural prostheses, cardiovascular materials, blood or bone substitutes, controlled drug delivery, orthopedic prostheses, dental materials, artificial organs, plasma- and cytapheresis, and dialysis are discussed.

  17. Inverted organic photosensitive device

    SciTech Connect

    Forrest, Stephen R.; Tong, Xiaoran; Lee, Jun Yeob; Cho, Yong Joo

    2015-09-08

    There is disclosed a method for preparing the surface of a metal substrate. The present disclosure also relates to an organic photovoltaic device including a metal substrate made by such method. Also disclosed herein is an inverted photosensitive device including a stainless steel foil reflective electrode, an organic donor-acceptor heterojunction over the reflective electrode, and a transparent electrode over the donor-acceptor heterojunction.

  18. Atherectomy devices: technology update

    PubMed Central

    Akkus, Nuri I; Abdulbaki, Abdulrahman; Jimenez, Enrique; Tandon, Neeraj

    2015-01-01

    Atherectomy is a procedure which is performed to remove atherosclerotic plaque from diseased arteries. Atherosclerotic plaques are localized in either coronary or peripheral arterial vasculature and may have different characteristics depending on the texture of the plaque. Atherectomy has been used effectively in treatment of both coronary and peripheral arterial disease. Atherectomy devices are designed differently to either cut, shave, sand, or vaporize these plaques and have different indications. In this article, current atherectomy devices are reviewed. PMID:25565904

  19. Raney nickel catalytic device

    DOEpatents

    O'Hare, Stephen A.

    1978-01-01

    A catalytic device for use in a conventional coal gasification process which includes a tubular substrate having secured to its inside surface by expansion a catalytic material. The catalytic device is made by inserting a tubular catalytic element, such as a tubular element of a nickel-aluminum alloy, into a tubular substrate and heat-treating the resulting composite to cause the tubular catalytic element to irreversibly expand against the inside surface of the substrate.

  20. Recurrent deletions and duplications of chromosome 2q11.2 and 2q13 are associated with variable outcomes.

    PubMed

    Riley, Kacie N; Catalano, Lisa M; Bernat, John A; Adams, Stacie D; Martin, Donna M; Lalani, Seema R; Patel, Ankita; Burnside, Rachel D; Innis, Jeffrey W; Rudd, M Katharine

    2015-11-01

    Copy number variation (CNV) in the long arm of chromosome 2 has been implicated in developmental delay (DD), intellectual disability (ID), autism spectrum disorder (ASD), congenital anomalies, and psychiatric disorders. Here we describe 14 new subjects with recurrent deletions and duplications of chromosome 2q11.2, 2q13, and 2q11.2-2q13. Though diverse phenotypes are associated with these CNVs, some common features have emerged. Subjects with 2q11.2 deletions often exhibit DD, speech delay, and attention deficit hyperactivity disorder (ADHD), whereas those with 2q11.2 duplications have DD, gastroesophageal reflux, and short stature. Congenital heart defects (CHDs), hypotonia, dysmorphic features, and abnormal head size are common in those with 2q13 deletions. In the 2q13 duplication cohort, we report dysmorphic features, DD, and abnormal head size. Two individuals with large duplications spanning 2q11.2-2q13 have dysmorphic features, hypotonia, and DD. This compilation of clinical features associated with 2q CNVs provides information that will be useful for healthcare providers and for families of affected children. However, the reduced penetrance and variable expressivity associated with these recurrent CNVs makes genetic counseling and prediction of outcomes challenging. © 2015 Wiley Periodicals, Inc. PMID:26227573

  1. Del(18)(q12.2q21.1) syndrome: a case report and clinical review of the literature.

    PubMed

    Imataka, G; Ohwada, Y; Shimura, N; Yoshihara, S; Arisaka, O

    2015-09-01

    The terminal deletion of the long arm of chromosome 18 is relatively common among cytogenetic abnormalities, which occur incidentally in approximately 1 in 40,000 live births. Proximal interstitial deletions of the long arm of chromosome 18 are less frequent. The critical region on chromosome 18 of this syndrome is del(18)(q12.2q21.1) and has recently been recognized as a new clinical entity. We describe a 8-year-old boy with developmental delay, obesity, and epilepsy, with characteristic facial anomalies in whom G-banding chromosome analysis revealed a unique karyotype of 46, XY, del(18)(q12.2q21.1). The patient was diagnosed with interstitial deletion chromosome 18q-syndrome. He received weight control therapy from a medical dietitian. For his epilepsy, he was administered oral carbamazepine at 4 mg/kg/day. At age six, he entered a special needs elementary school. After entering school, he often showed hyperkinesis, and was diagnosed with attention deficit hyperactivity disorder with mild mental retardation. Because patients with only del(18)(q12.2q21.1) have no serious associated malformations, physicians should be aware that even adult patients may have 18q-syndrome. Therefore, if epilepsy occurs in patients with minor facial anomalies, psychomotor retardation, obesity, and the possibility of 18q-syndrome with del(18)(q12.2q21.1) should be kept in mind, and chromosome testing should be performed. PMID:26400529

  2. Topical treatment with coenzyme Q10-containing formulas improves skin's Q10 level and provides antioxidative effects.

    PubMed

    Knott, Anja; Achterberg, Volker; Smuda, Christoph; Mielke, Heiko; Sperling, Gabi; Dunckelmann, Katja; Vogelsang, Alexandra; Krüger, Andrea; Schwengler, Helge; Behtash, Mojgan; Kristof, Sonja; Diekmann, Heike; Eisenberg, Tanya; Berroth, Andreas; Hildebrand, Janosch; Siegner, Ralf; Winnefeld, Marc; Teuber, Frank; Fey, Sven; Möbius, Janne; Retzer, Dana; Burkhardt, Thorsten; Lüttke, Juliane; Blatt, Thomas

    2015-01-01

    Ubiquinone (coenzyme Q10, Q10) represents an endogenously synthesized lipid-soluble antioxidant which is crucial for cellular energy production but is diminished with age and under the influence of external stress factors in human skin. Here, it is shown that topical Q10 treatment is beneficial with regard to effective Q10 replenishment, augmentation of cellular energy metabolism, and antioxidant effects. Application of Q10-containing formulas significantly increased the levels of this quinone on the skin surface. In the deeper layers of the epidermis the ubiquinone level was significantly augmented indicating effective supplementation. Concurrent elevation of ubiquinol levels suggested metabolic transformation of ubiquinone resulting from increased energy metabolism. Incubation of cultured human keratinocytes with Q10 concentrations equivalent to treated skin showed a significant augmentation of energy metabolism. Moreover, the results demonstrated that stressed skin benefits from the topical Q10 treatment by reduction of free radicals and an increase in antioxidant capacity. PMID:26648450

  3. Wireless device monitoring systems and monitoring devices, and associated methods

    DOEpatents

    McCown, Steven H; Derr, Kurt W; Rohde, Kenneth W

    2014-05-27

    Wireless device monitoring systems and monitoring devices include a communications module for receiving wireless communications of a wireless device. Processing circuitry is coupled with the communications module and configured to process the wireless communications to determine whether the wireless device is authorized or unauthorized to be present at the monitored area based on identification information of the wireless device. Methods of monitoring for the presence and identity of wireless devices are also provided.

  4. Analysis of group differences in processing speed: Brinley plots, Q-Q plots, and other conspiracies.

    PubMed

    Myerson, Joel; Adams, David R; Hale, Sandra; Jenkins, Lisa

    2003-03-01

    Researchers in a growing number of areas (including cognitive development, aging, and neuropsychology) use Brinley plots to compare the processing speed of different groups. Ratcliff, Spieler, and McKoon (2000) argued that a Brinley plot is a quantile-quantile (Q-Q) plot and that therefore Brinley plot regression slopes measure standard deviation ratios rather than relative speed of processing. We show that this argument is incorrect. Brinley plots, by definition, are not Q-Q plots; the former are based on unranked data and the latter are based on ranked data. Furthermore, the relationship between standard deviation ratios and slopes is a general property of regression lines and has no implications for the use of Brinley plot regression slopes as processing speed measures. We also show that the relative speed interpretation of Brinley plot slopes is strongly supported by converging evidence from a metaanalysis of visual search, mental rotation, and memory scanning in young and older adults. As to Ratcliff et al.'s hypothesis that age differences in response time are attributable to greater cautiousness on the part of the elderly, rather than true processing speed differences, this hypothesis has been extensively tested in previous studies and found wanting. PMID:12747512

  5. New q-ary quantum MDS codes with distances bigger than q/2

    NASA Astrophysics Data System (ADS)

    He, Xianmang; Xu, Liqing; Chen, Hao

    2016-07-01

    The construction of quantum MDS codes has been studied by many authors. We refer to the table in page 1482 of (IEEE Trans Inf Theory 61(3):1474-1484, 2015) for known constructions. However, there have been constructed only a few q-ary quantum MDS [[n,n-2d+2,d

  6. Partial monosomy 11q and trisomy 12q: variable expression in two siblings.

    PubMed

    Lukusa, T; Holvoet, M; Vermeesch, J R; Devriendt, K; Fryns, J P

    2003-01-01

    Clinical and cytogenetical findings are reported and discussed on two siblings with discordant phenotypes despite having both a terminal 11q deletion and a distal 12q duplication resulting from an unbalanced segregation of a balanced translocation t(11:12)(q23:q24.1) mat. The oldest child, a girl, is the index patient. Her clinical features include intrauterine and postnatal growth retardation, fetal distress, mild hypotonia, early feeding difficulties, moderate developmental delay, especially in language acquisition, a velopharyngeal insufficiency with repeated otorhinopharyngeal infections, facial dysmorphism, heart ventricular septal defect, and abnormal hyperactive behaviour with sometimes autistic tendencies. The facial dysmorphic features notably consist of microcephaly, hypertelorism, large palpebral fissures, large eyes with alternant divergent strabismus, long eyelashes, a long and broad nasal bridge, a short "crested" nose with salient tip, a fishmouth with large spaces between teeth and flat palate, retrognathism, large ears and multiple dimples. The second affected child is a boy showing low birthweight, moderate developmental retardation with mainly no active language at 32 months, behaviour abnormalities with an autistic tendency, and no major physical anomalies apart from a slight facial hypotonia with often open mouth, dimples on the shoulders and right cryptorchidism. The authors stress the variable clinical expression of the chromosomal imbalance in this family resulting in low birthweight, developmental delay, abnormal behaviour, but different degrees of physical features and dysmorphism. The possible contribution of each of the two aneusomies to the phenotype is discussed. PMID:12872809

  7. New q-ary quantum MDS codes with distances bigger than q/2

    NASA Astrophysics Data System (ADS)

    He, Xianmang; Xu, Liqing; Chen, Hao

    2016-04-01

    The construction of quantum MDS codes has been studied by many authors. We refer to the table in page 1482 of (IEEE Trans Inf Theory 61(3):1474-1484, 2015) for known constructions. However, there have been constructed only a few q-ary quantum MDS [[n,n-2d+2,d

  8. A new autosomal recessive retinitis pigmentosa locus maps on chromosome 2q31-q33.

    PubMed Central

    Bayés, M; Goldaracena, B; Martínez-Mir, A; Iragui-Madoz, M I; Solans, T; Chivelet, P; Bussaglia, E; Ramos-Arroyo, M A; Baiget, M; Vilageliu, L; Balcells, S; Gonzàlez-Duarte, R; Grinberg, D

    1998-01-01

    Autosomal recessive retinitis pigmentosa (ARRP) is a genetically heterogeneous disease. To date, mutations in four members of the phototransduction cascade have been implicated in ARRP. Additionally, linkage of the disease to three loci on 1p, 1q, and 6p has been described. However, the majority of cases are still uncharacterised. We have performed linkage analysis in a large nuclear ARRP family with five affected sibs. After exclusion of several regions of the genome known to contain loci for retinal dystrophies, a genomic search for linkage to ARRP was undertaken. Positive lod scores were obtained with markers on 2q31-q33 (Zmax at theta = 0.00 of 4.03, 4.12, and 4.12 at D2S364, D2S118, and D2S389, respectively) defining an interval of about 7 cM for this new ARRP locus, between D2S148 and D2S161. Forty-four out of 47 additional ARRP families, tested with markers on 2q32, failed to show linkage, providing evidence of further genetic heterogeneity. Images PMID:9507394

  9. Formation of q{bar q} resonances in the {bar N}N system

    SciTech Connect

    Ivanov, N.Ya.

    1995-11-01

    The formation of q{bar q} resonances lying on the leading Regge trajectories in the {bar N}N system is studied in the quark-gluon string model. The model predicts strong suppression of the decays of q{bar q} states into {bar N}N pairs in relation to two-meson modes. The author`s analysis shows that the contributions of the resonances f{sub 4}(2050) (I{sup G}J{sup PC}= 0{sup +}4{sup ++}), {rho}{sub 5}(2240) (I{sup G}J{sup PC} = 1{sup +}5{sup {minus}{minus}}), and f{sub 6}(2510) (I{sup G}J{sup PC} = 0{sup +}6{sup ++}) to the processes of two-meson {bar N}N annihilation ({bar p}p {yields} {pi}{pi}, {bar K}K, {hor_ellipsis}) are about 1% of the corresponding experimental integrated cross sections. 30 refs., 2 figs., 1 tab.

  10. Multiple q-Shell ODF Reconstruction in q-Ball Imaging

    PubMed Central

    Aganj, Iman; Lenglet, Christophe; Sapiro, Guillermo; Yacoub, Essa; Ugurbil, Kamil; Harel, Noam

    2015-01-01

    Q-ball imaging (QBI) is a high angular resolution diffusion imaging (HARDI) technique which has been proven very successful in resolving multiple intravoxel fiber orientations in MR images. The standard computation of the orientation distribution function (ODF, the probability of diffusion in a given direction) from q-ball uses linear radial projection, neglecting the change in the volume element along the ray, thereby resulting in distributions different from the true ODFs. A new technique has been recently proposed that, by considering the solid angle factor, uses the mathematically correct definition of the ODF and results in a dimensionless and normalized ODF expression from a single q-shell. In this paper, we extend this technique in order to exploit HARDI data from multiple q-shells. We consider the more flexible multi-exponential model for the diffusion signal, and show how to efficiently compute the ODFs in constant solid angle. We describe our method and demonstrate its improved performance on both artificial and real HARDI data. PMID:20426140

  11. Electronic security device

    DOEpatents

    Eschbach, Eugene A.; LeBlanc, Edward J.; Griffin, Jeffrey W.

    1992-01-01

    The present invention relates to a security device having a control box (12) containing an electronic system (50) and a communications loop (14) over which the system transmits a signal. The device is constructed so that the communications loop can extend from the control box across the boundary of a portal such as a door into a sealed enclosure into which access is restricted whereby the loop must be damaged or moved in order for an entry to be made into the enclosure. The device is adapted for detecting unauthorized entries into such enclosures such as rooms or containers and for recording the time at which such entries occur for later reference. Additionally, the device detects attempts to tamper or interfere with the operation of the device itself and records the time at which such events take place. In the preferred embodiment, the security device includes a microprocessor-based electronic system (50) and a detection module (72) capable of registering changes in the voltage and phase of the signal transmitted over the loop.

  12. Electronic security device

    DOEpatents

    Eschbach, E.A.; LeBlanc, E.J.; Griffin, J.W.

    1992-03-17

    The present invention relates to a security device having a control box containing an electronic system and a communications loop over which the system transmits a signal. The device is constructed so that the communications loop can extend from the control box across the boundary of a portal such as a door into a sealed enclosure into which access is restricted whereby the loop must be damaged or moved in order for an entry to be made into the enclosure. The device is adapted for detecting unauthorized entries into such enclosures such as rooms or containers and for recording the time at which such entries occur for later reference. Additionally, the device detects attempts to tamper or interfere with the operation of the device itself and records the time at which such events take place. In the preferred embodiment, the security device includes a microprocessor-based electronic system and a detection module capable of registering changes in the voltage and phase of the signal transmitted over the loop. 11 figs.

  13. Contamination control device

    DOEpatents

    Clark, Robert M.; Cronin, John C.

    1977-01-01

    A contamination control device for use in a gas-insulated transmission bus consisting of a cylindrical center conductor coaxially mounted within a grounded cylindrical enclosure. The contamination control device is electrically connected to the interior surface of the grounded outer shell and positioned along an axial line at the lowest vertical position thereon. The contamination control device comprises an elongated metallic member having a generally curved cross-section in a first plane perpendicular to the axis of the bus and having an arcuate cross-section in a second plane lying along the axis of the bus. Each opposed end of the metallic member and its opposing sides are tapered to form a pair of generally converging and downward sloping surfaces to trap randomly moving conductive particles in the relatively field-free region between the metallic member and the interior surface of the grounded outer shell. The device may have projecting legs to enable the device to be spot welded to the interior of the grounded housing. The control device provides a high capture probability and prevents subsequent release of the charged particles after the capture thereof.

  14. Q-switched Tm3+-doped fiber laser with a micro-fiber based black phosphorus saturable absorber

    NASA Astrophysics Data System (ADS)

    Wang, Yazhou; Li, Jianfeng; Han, Lian; Lu, Rongguo; Hu, Yunxiao; Li, Zhuo; Liu, Yong

    2016-06-01

    We report a passively Q-switched Tm3+-doped fiber laser using a black phosphorus deposited micro-fiber (BPDMF) as a saturable absorption (SA) device for the first time. The BPDMF prepared by depositing black phosphorus (BP) on the micro-fiber waist with heat convention effect and optical tweezer effect has a measured modulation depth of 40.2% and a nonsaturable loss of 55.9%. By employing this device in an all-fiber ring cavity, a stable Q-switched pulse train at 1948 nm was achieved with a repetition rate from 12.5 to 28.1 kHz and a pulse width from 15.1 to 5.6 μs, respectively.

  15. How does gravity save or kill Q-balls?

    SciTech Connect

    Tamaki, Takashi; Sakai, Nobuyuki

    2011-02-15

    We explore stability of gravitating Q-balls with potential V{sub 4}({phi})=(m{sup 2}/2){phi}{sup 2}-{lambda}{phi}{sup 4}+({phi}{sup 6}/M{sup 2}) via catastrophe theory, as an extension of our previous work on Q-balls with potential V{sub 3}({phi})=(m{sup 2}/2){phi}{sup 2}-{mu}{phi}{sup 3}+{lambda}{phi}{sup 4}. In flat spacetime Q-balls with V{sub 4} in the thick-wall limit are unstable and there is a minimum charge Q{sub min}, where Q-balls with Q{sub min} are nonexistent. If we take self-gravity into account, on the other hand, there exist stable Q-balls with arbitrarily small charge, no matter how weak gravity is. That is, gravity saves Q-balls with small charge. We also show how stability of Q-balls changes as gravity becomes strong.

  16. Charged Q -balls in gauge mediated SUSY breaking models

    NASA Astrophysics Data System (ADS)

    Hong, Jeong-Pyong; Kawasaki, Masahiro; Yamada, Masaki

    2015-09-01

    It is known that after Affleck-Dine baryogenesis, spatial inhomogeneities of Affleck-Dine field grow into nontopological solitons called Q-balls. In gauge mediated supersymmetry (SUSY) breaking models, sufficiently large Q-balls with baryon charge are stable while Q-balls with lepton charge can always decay into leptons. For a Q-ball that carries nonzero B and L charges, the difference between the baryonic component and the leptonic component in decay rate may induce nonzero electric charge on the Q-ball. This implies that a charged Q-ball, also called gauged Q-ball, may emerge in our universe. In this paper, we investigate two complex scalar fields, a baryonic scalar field and a leptonic one, in an Abelian gauge theory. We find stable solutions of gauged Q-balls for different baryon and lepton charges. Those solutions show that a Coulomb potential arises and the Q-ball becomes electrically charged as expected. It is energetically favored that some amount of leptonic component decays, but there is an upper bound on its amount due to the Coulomb force. The baryonic decay also becomes possible by virtue of electrical repulsion, but we find that the evolution itself stops before it occurs mainly due to the Schwinger limit, so that the charged Q-balls eventually survive in the universe.

  17. Pisot q-coherent states quantization of the harmonic oscillator

    SciTech Connect

    Gazeau, J.P.; Olmo, M.A. del

    2013-03-15

    We revisit the quantized version of the harmonic oscillator obtained through a q-dependent family of coherent states. For each q, 0<q<1, these normalized states form an overcomplete set that resolves the unity with respect to an explicit measure. We restrict our study to the case in which q{sup -1} is a quadratic unit Pisot number, since then the q-deformed integers form Fibonacci-like sequences of integers. We then examine the main characteristics of the corresponding quantum oscillator: localization in the configuration and in the phase spaces, angle operator, probability distributions and related statistical features, time evolution and semi-classical phase space trajectories. - Highlights: Black-Right-Pointing-Pointer Quantized version of the harmonic oscillator (HO) through a q-family of coherent states. Black-Right-Pointing-Pointer For q,0<q<1 these normalized states form an overcomplete set that resolves the unity with respect to an explicit measure. Black-Right-Pointing-Pointer q-Deformed numbers are Fibonacci-like integer sequences (1/q a quadratic unit Pisot number). Black-Right-Pointing-Pointer We examine the main physical characteristics of the corresponding quantum oscillator.

  18. Radiographic quality control devices.

    PubMed

    2000-04-01

    In this study, we evaluate eight radiographic quality control (QC) devices, which noninvasively measure the output from a variety of diagnostic x-ray production systems. When used as part of a quality assurance (QA) program, radiographic QC devices help ensure that x-ray equipment is working within acceptable limits. This in turn helps ensure that high-quality images are achieved with appropriate radiation doses and that resources are used efficiently (for example, by minimizing the number of repeat exposures required). Our testing focused on the physical performance, ease of use, and service and maintenance characteristics that affect the use of these devices for periodic, routine measurements of x-ray system parameters. We found that all the evaluated models satisfactorily measure all the parameters normally needed for a QA program. However, we did identify a number of differences among the models--particularly in the range of exposure levels that can be effectively measured and the ease of use. Three models perform well for a variety of applications and are very easy to use; we rate them Preferred. Three additional models have minor limitations but otherwise perform well; we rate them Acceptable. We recommend against purchasing two models because, although each performs acceptably for most applications, neither model can measure low levels of radiation. This Evaluation covers devices designed to measure the output of x-ray tubes noninvasively. These devices, called radiographic quality control (QC) devices, or QC meters, are typically used by medical physicists, x-ray engineers, biomedical engineers, and suitably trained radiographic technologists to make QC measurements. We focus on the use of these devices as part of an overall quality assurance (QA) program. We have not evaluated their use for other applications, such as acceptance testing. To be included in this study, a device must be able to measure the exposure- and kVp-related characteristics of most x

  19. Performance of passive Q-switched solar-pumped high-power Nd:YAG lasers

    NASA Astrophysics Data System (ADS)

    Noter, Yoram; Naftali, Nir; Pe'er, Idit L.; Yogev, Amnon; Lando, Mordechai; Shimony, Yehoshua

    1997-09-01

    Q-switched, solar-pumped, high power Nd:YAG lasers are attractive for a variety of applications requiring high instantaneous peak power density. The Q-switching can be obtained by an acousto-optic, electro-optic or passive device. Passive Q-switching seems an excellent choice for space as well as for other applications since it neither requires an external driver nor an electrical power supply. In recent years Cr+4:YAG single crystals were extensively used as passive Q-switches for flashlamp-pumped high power Nd:YAG lasers, demonstrating their superior thermal superior thermal characteristics and durability. In this work we report the first operation of passive Q- switched, solar-pumped, high power Nd:YAG lasers. The concentrated solar energy for he optical pumping of the laser was obtained by a 3-stage combination of imaging and non-imaging optics. It included: i) Weizmann Institute solar tower heliostats, ii) 3D compound parabolic concentrator, and iii) 2D compound parabolic concentrator in which the laser rod was placed. 72 mm long laser rods with either 3 mm or 4 mm diameter were used. The passive Q-switch was made from a Cr$=+4):YAG single crystal having a low- intensity transmission of 72 percent at 1.06 (mu) . Its rear surface was coated by a high reflectivity coating, serving as the rear mirror of the cavity. Output coupling mirrors with various reflectivities were used. The passive Q-switch demonstrated excellent durability and reliability during all the experiments. Repetition rates of 6-39 kHz were measured, showing higher repetition rates at higher laser power levels. The pulses demonstrated shorter full width at half maximum (FWHM) time for higher laser power elves, and the FWHM time range was 190-310 nsec. The maximal measured average power was 14 W. Thermal lensing was measured as a function of the absorbed solar power in the laser rod. It is estimated that laser peak power densities of approximately 100 kW/cm2 were achieved in the experiments. It is

  20. Cataphoric devices in spoken discourse.

    PubMed

    Gernsbacher, M A; Jescheniak, J D

    1995-08-01

    We propose that speakers mark key words with cataphoric devices. Cataphoric devices are counterparts to anaphoric devices: Just as anaphoric devices enable backward reference, cataphoric devices enable forward reference. And just as anaphoric devices mark concepts that have been mentioned before, cataphoric devices mark concepts that are likely to be mentioned again. We investigated two cataphoric devices: spoken stress and the indefinite this. Our experiments demonstrated three ways that concepts marked by cataphoric devices gain a privileged status in listeners' mental representations: Cataphoric devices enhance the activation of the concepts that they mark; cataphoric devices suppress the activation of previously mentioned concepts; and cataphoric devices protect the concepts that they mark from being suppressed by subsequently mentioned concepts. PMID:7641525

  1. Diamond Electronic Devices

    NASA Astrophysics Data System (ADS)

    Isberg, J.

    2010-11-01

    For high-power and high-voltage applications, silicon is by far the dominant semiconductor material. However, silicon has many limitations, e.g. a relatively low thermal conductivity, electric breakdown occurs at relatively low fields and the bandgap is 1.1 eV which effectively limits operation to temperatures below 175° C. Wide-bandgap materials, such as silicon carbide (SiC), gallium nitride (GaN) and diamond offer the potential to overcome both the temperature and power handling limitations of silicon. Diamond is the most extreme in this class of materials. By the fundamental material properties alone, diamond offers the largest benefits as a semiconductor material for power electronic applications. On the other hand, diamond has a problem with a large carrier activation energy of available dopants which necessitates specialised device concepts to allow room temperature (RT) operation. In addition, the role of common defects on the charge transport properties of diamond is poorly understood. Notwithstanding this, many proof-of-principle two-terminal and three-terminal devices have been made and tested. Two-terminal electronic diamond devices described in the literature include: p-n diodes, p-i-n diodes, various types of radiation detectors, Schottky diodes and photoconductive or electron beam triggered switches. Three terminal devices include e.g. MISFETs and JFETs. However, the development of diamond devices poses great challenges for the future. A particularly interesting way to overcome the doping problem, for which there has been some recent progress, is to make so-called delta doped (or pulse-doped) devices. Such devices utilise very thin (˜1 nm) doped layers in order to achieve high RT activation.

  2. Diamond Electronic Devices

    SciTech Connect

    Isberg, J.

    2010-11-01

    For high-power and high-voltage applications, silicon is by far the dominant semiconductor material. However, silicon has many limitations, e.g. a relatively low thermal conductivity, electric breakdown occurs at relatively low fields and the bandgap is 1.1 eV which effectively limits operation to temperatures below 175 deg.n C. Wide-bandgap materials, such as silicon carbide (SiC), gallium nitride (GaN) and diamond offer the potential to overcome both the temperature and power handling limitations of silicon. Diamond is the most extreme in this class of materials. By the fundamental material properties alone, diamond offers the largest benefits as a semiconductor material for power electronic applications. On the other hand, diamond has a problem with a large carrier activation energy of available dopants which necessitates specialised device concepts to allow room temperature (RT) operation. In addition, the role of common defects on the charge transport properties of diamond is poorly understood. Notwithstanding this, many proof-of-principle two-terminal and three-terminal devices have been made and tested. Two-terminal electronic diamond devices described in the literature include: p-n diodes, p-i-n diodes, various types of radiation detectors, Schottky diodes and photoconductive or electron beam triggered switches. Three terminal devices include e.g. MISFETs and JFETs. However, the development of diamond devices poses great challenges for the future. A particularly interesting way to overcome the doping problem, for which there has been some recent progress, is to make so-called delta doped (or pulse-doped) devices. Such devices utilise very thin ({approx}1 nm) doped layers in order to achieve high RT activation.

  3. Development of a Sampling Collection Device with Diagnostic Procedures.

    PubMed

    Cheng, Jhih-Yan; Feng, Mow-Jung; Wu, Chia-Chi; Wang, Jane; Chang, Ting-Chang; Cheng, Chao-Min

    2016-08-01

    Cervicovaginal fluid plays an important role in the detection of many female genital diseases, but the lack of suitable collection devices in the market severely challenges test success rate. Appropriate clinical sampling devices for cervicovaginal fluid collection would help physicians detect diseases and disease states more rapidly, efficiently, and accurately. The objective of this study was to develop a readily usable sampling collection device that would eliminate macromolecular interference and accurately provide specimens for further studies. This study was designed to develop an effective device to collect cervicovaginal fluid from women with symptoms of endometrial lesions, women appearing in the clinic for a routine Papanicolaou smear, and/or women seeking a routine gynecologic checkup. Paper-based assay, ELISA, and qNano were used to provide accurate diagnoses. A total of 103 patients successfully used the developed device to collect cervicovaginal fluid. Some of the collected specimens were used to detect glycogen, lactate, and pH for determining pathogen infection. Other specimen samples were tested for the presence of female genital cancer by comparing interleukin 6 concentration and microvesicle concentration. We proposed a noninvasive screening test for the diagnosis of female genital diseases using a dual-material collection device. The outer, nonwoven fabric portion of this device was designed to filter macromolecules, and the inner cotton portion was designed to absorb cervicovaginal fluid. PMID:27338148

  4. Meromorphic solutions to the q-Painlevé equations around the origin

    NASA Astrophysics Data System (ADS)

    Ohyama, Y.

    2015-04-01

    We study meromorphic solutions to the q-Painlevé equations with type VI, V, III around the origin. Since the origin of q-PVI, q-PV and q-PIII are singular points of the q-Briot- Bouquet type, they have holomorphic solutions for generic parameters. The q-PVI, q-PV and q-PIII have four, three and two meromorphic solutions around the origin respectively. We can solve linear connection problems for holomorphic solutions.

  5. Prediction of Stereochemistry using Q2MM.

    PubMed

    Hansen, Eric; Rosales, Anthony R; Tutkowski, Brandon; Norrby, Per-Ola; Wiest, Olaf

    2016-05-17

    The standard method of screening ligands for selectivity in asymmetric, transition metal-catalyzed reactions requires experimental testing of hundreds of ligands from ligand libraries. This "trial and error" process is costly in terms of time as well as resources and, in general, is scientifically and intellectually unsatisfying as it reveals little about the underlying mechanism behind the selectivity. The accurate computational prediction of stereoselectivity in enantioselective catalysis requires adequate conformational sampling of the selectivity-determining transition state but has to be fast enough to compete with experimental screening techniques to be useful for the synthetic chemist. Although electronic structure calculations are accurate and general, they are too slow to allow for sampling or fast screening of ligand libraries. The combined requirements can be fulfilled by using appropriately fitted transition state force fields (TSFFs) that represent the transition state as a minimum and allow fast conformational sampling using Monte Carlo. Quantum-guided molecular mechanics (Q2MM) is an automated force field parametrization method that generates accurate, reaction-specific TSFFs by fitting the functional form of an arbitrary force field using only electronic structure calculations by minimization of an objective function. A key feature that distinguishes the Q2MM method from many other automated parametrization procedures is the use of the Hessian matrix in addition to geometric parameters and relative energies. This alleviates the known problems of overfitting of TSFFs. After validation of the TSFF by comparison to electronic structure results for a test set and available experimental data, the stereoselectivity of a reaction can be calculated by summation over the Boltzman-averaged relative energies of the conformations leading to the different stereoisomers. The Q2MM method has been applied successfully to perform virtual ligand screens on a range of

  6. Actively Q-switched Raman fiber laser

    NASA Astrophysics Data System (ADS)

    Kuznetsov, A. G.; Podivilov, E. V.; Babin, S. A.

    2015-03-01

    A new scheme providing actively Q-switched operation of a Raman fiber laser (RFL) has been proposed and tested. The RFL consists of a 1 km single-mode fiber with a switchable loop mirror at one end and an angled cleaved output end. An 1080 nm pulse with microsecond duration is generated at the output by means of acousto-optic switching of the mirror at ~30 kHz in the presence of 6 W backward pumping at 1030 nm. In the proposed scheme, the generated pulse energy is defined by the pump energy distributed along the passive fiber, which amounts to 30 μJ in our case. The available pump energy may be increased by means of fiber lengthening. Pulse shortening is also expected.

  7. Prediction of Stereochemistry using Q2MM

    PubMed Central

    2016-01-01

    Conspectus The standard method of screening ligands for selectivity in asymmetric, transition metal-catalyzed reactions requires experimental testing of hundreds of ligands from ligand libraries. This “trial and error” process is costly in terms of time as well as resources and, in general, is scientifically and intellectually unsatisfying as it reveals little about the underlying mechanism behind the selectivity. The accurate computational prediction of stereoselectivity in enantioselective catalysis requires adequate conformational sampling of the selectivity-determining transition state but has to be fast enough to compete with experimental screening techniques to be useful for the synthetic chemist. Although electronic structure calculations are accurate and general, they are too slow to allow for sampling or fast screening of ligand libraries. The combined requirements can be fulfilled by using appropriately fitted transition state force fields (TSFFs) that represent the transition state as a minimum and allow fast conformational sampling using Monte Carlo. Quantum-guided molecular mechanics (Q2MM) is an automated force field parametrization method that generates accurate, reaction-specific TSFFs by fitting the functional form of an arbitrary force field using only electronic structure calculations by minimization of an objective function. A key feature that distinguishes the Q2MM method from many other automated parametrization procedures is the use of the Hessian matrix in addition to geometric parameters and relative energies. This alleviates the known problems of overfitting of TSFFs. After validation of the TSFF by comparison to electronic structure results for a test set and available experimental data, the stereoselectivity of a reaction can be calculated by summation over the Boltzman-averaged relative energies of the conformations leading to the different stereoisomers. The Q2MM method has been applied successfully to perform virtual ligand

  8. All fiber passively Q-switched laser

    DOEpatents

    Soh, Daniel B. S.; Bisson, Scott E

    2015-05-12

    Embodiments relate to an all fiber passively Q-switched laser. The laser includes a large core doped gain fiber having a first end. The large core doped gain fiber has a first core diameter. The laser includes a doped single mode fiber (saturable absorber) having a second core diameter that is smaller than the first core diameter. The laser includes a mode transformer positioned between a second end of the large core doped gain fiber and a first end of the single mode fiber. The mode transformer has a core diameter that transitions from the first core diameter to the second core diameter and filters out light modes not supported by the doped single mode fiber. The laser includes a laser cavity formed between a first reflector positioned adjacent the large core doped gain fiber and a second reflector positioned adjacent the doped single mode fiber.

  9. Chromosomal data relevant for Q values

    NASA Astrophysics Data System (ADS)

    Edwards, A. A.

    1992-07-01

    It has been known for many years that relationships between absorbed dose and biological effect vary with the type of radiation. In particular, neutrons and alpha particles are more damaging than x or γ radiations. This applies to a range of biological effects such as cell killing, chromosome aberrations, cell mutation, cell transformation as well as life shortening and cancer induction in animals. The application of this knowledge to devise a scheme for specifying the quality factor (Q) in radiological protection has been the subject of much debate. There are no tumour data in humans from which the quality factor may be derived. The problems of using animal and cell transformation data which are probably the next best choice are discussed. The extensive data base on chromosomal aberrations in human lymphocytes is described and discussed in terms of relevance to deducing quality factors. Particular emphasis is placed on data obtained at low doses and low dose rates.

  10. The Moon's Molten Core and Tidal Q

    NASA Technical Reports Server (NTRS)

    Williams, J. G.; Boggs, D. H.; Ratcliff, J. T.; Dickey, J. O.

    1998-01-01

    The rotation of the Moon is influenced by solid-body tides and interaction at a liquid-core/solid-mantle boundary. The Lunar Laser Ranging (LLR) data are sensitive to variations in lunar rotation. Analysis of those ranges reveals four dissipation periodicities in the rotation. These signatures can be explained with the combined effects of tide plus core, but not with either alone. The fluid core detection exceeds three times its uncertainty. The inferred core radius has a 1 -sigma upper limit of 352 km for iron and up to 374 km if sulfur is present. The tidal dissipation is strong, Q at one month is 37 +/- 5 .Q increases for longer periods and is 60 (-15, +40) at one year.Dynamical evidence for a fluid lunar core has previously been presented. These-earlier solutions included three dissipation parameters. New solutions benefit from additional LLR data and an improved gravity field from Doppler tracking of Lunar Prospector. Five dissipation parameters are now solved for. There are several options for dissipation parameters: a core coupling parameter, a time delay for tidal distortion of the moments of inertia, and five periodic terms in the rotation angles. Solutions with different combinations of these are compatible (a theory relates K/C and time delay to a series of periodic terms). The solutions used K/C, time delay, and one periodic term. When dissipation signatures at five rotation frequencies are solved for, four amplitudes (4 to 263 milliarcseconds) are detected above the noise. Attempts to explain these results using either tides alone or core alone fail (less than 3(sigma) discrepancy for the former and 9(sigma), for the latter). A combination of tides and liquid core matches the results well.

  11. Unsaturated Long Chain Free Fatty Acids Are Input Signals of the Salmonella enterica PhoP/PhoQ Regulatory System*

    PubMed Central

    Viarengo, Gastón; Sciara, Mariela I.; Salazar, Mario O.; Kieffer, Pablo M.; Furlán, Ricardo L. E.; García Véscovi, Eleonora

    2013-01-01

    The Salmonella enterica serovar Typhimurium PhoP/PhoQ system has largely been studied as a paradigmatic two-component regulatory system not only to dissect structural and functional aspects of signal transduction in bacteria but also to gain knowledge about the versatile devices that have evolved allowing a pathogenic bacterium to adjust to or counteract environmental stressful conditions along its life cycle. Mg2+ limitation, acidic pH, and the presence of cationic antimicrobial peptides have been identified as cues that the sensor protein PhoQ can monitor to reprogram Salmonella gene expression to cope with extra- or intracellular challenging conditions. In this work, we show for the first time that long chain unsaturated free fatty acids (LCUFAs) present in Salmonella growth medium are signals specifically detected by PhoQ. We demonstrate that LCUFAs inhibit PhoQ autokinase activity, turning off the expression of the PhoP-dependent regulon. We also show that LCUFAs exert their action independently of their cellular uptake and metabolic utilization by means of the β-oxidative pathway. Our findings put forth the complexity of input signals that can converge to finely tune the activity of the PhoP/PhoQ system. In addition, they provide a new potential biochemical platform for the development of antibacterial strategies to fight against Salmonella infections. PMID:23782700

  12. Unsaturated long chain free fatty acids are input signals of the Salmonella enterica PhoP/PhoQ regulatory system.

    PubMed

    Viarengo, Gastón; Sciara, Mariela I; Salazar, Mario O; Kieffer, Pablo M; Furlán, Ricardo L E; García Véscovi, Eleonora

    2013-08-01

    The Salmonella enterica serovar Typhimurium PhoP/PhoQ system has largely been studied as a paradigmatic two-component regulatory system not only to dissect structural and functional aspects of signal transduction in bacteria but also to gain knowledge about the versatile devices that have evolved allowing a pathogenic bacterium to adjust to or counteract environmental stressful conditions along its life cycle. Mg(2+) limitation, acidic pH, and the presence of cationic antimicrobial peptides have been identified as cues that the sensor protein PhoQ can monitor to reprogram Salmonella gene expression to cope with extra- or intracellular challenging conditions. In this work, we show for the first time that long chain unsaturated free fatty acids (LCUFAs) present in Salmonella growth medium are signals specifically detected by PhoQ. We demonstrate that LCUFAs inhibit PhoQ autokinase activity, turning off the expression of the PhoP-dependent regulon. We also show that LCUFAs exert their action independently of their cellular uptake and metabolic utilization by means of the β-oxidative pathway. Our findings put forth the complexity of input signals that can converge to finely tune the activity of the PhoP/PhoQ system. In addition, they provide a new potential biochemical platform for the development of antibacterial strategies to fight against Salmonella infections. PMID:23782700

  13. Identification of Coq11, a New Coenzyme Q Biosynthetic Protein in the CoQ-Synthome in Saccharomyces cerevisiae*

    PubMed Central

    Allan, Christopher M.; Awad, Agape M.; Johnson, Jarrett S.; Shirasaki, Dyna I.; Wang, Charles; Blaby-Haas, Crysten E.; Merchant, Sabeeha S.; Loo, Joseph A.; Clarke, Catherine F.

    2015-01-01

    Coenzyme Q (Q or ubiquinone) is a redox active lipid composed of a fully substituted benzoquinone ring and a polyisoprenoid tail and is required for mitochondrial electron transport. In the yeast Saccharomyces cerevisiae, Q is synthesized by the products of 11 known genes, COQ1–COQ9, YAH1, and ARH1. The function of some of the Coq proteins remains unknown, and several steps in the Q biosynthetic pathway are not fully characterized. Several of the Coq proteins are associated in a macromolecular complex on the matrix face of the inner mitochondrial membrane, and this complex is required for efficient Q synthesis. Here, we further characterize this complex via immunoblotting and proteomic analysis of tandem affinity-purified tagged Coq proteins. We show that Coq8, a putative kinase required for the stability of the Q biosynthetic complex, is associated with a Coq6-containing complex. Additionally Q6 and late stage Q biosynthetic intermediates were also found to co-purify with the complex. A mitochondrial protein of unknown function, encoded by the YLR290C open reading frame, is also identified as a constituent of the complex and is shown to be required for efficient de novo Q biosynthesis. Given its effect on Q synthesis and its association with the biosynthetic complex, we propose that the open reading frame YLR290C be designated COQ11. PMID:25631044

  14. Identification of Coq11, a new coenzyme Q biosynthetic protein in the CoQ-synthome in Saccharomyces cerevisiae.

    PubMed

    Allan, Christopher M; Awad, Agape M; Johnson, Jarrett S; Shirasaki, Dyna I; Wang, Charles; Blaby-Haas, Crysten E; Merchant, Sabeeha S; Loo, Joseph A; Clarke, Catherine F

    2015-03-20

    Coenzyme Q (Q or ubiquinone) is a redox active lipid composed of a fully substituted benzoquinone ring and a polyisoprenoid tail and is required for mitochondrial electron transport. In the yeast Saccharomyces cerevisiae, Q is synthesized by the products of 11 known genes, COQ1-COQ9, YAH1, and ARH1. The function of some of the Coq proteins remains unknown, and several steps in the Q biosynthetic pathway are not fully characterized. Several of the Coq proteins are associated in a macromolecular complex on the matrix face of the inner mitochondrial membrane, and this complex is required for efficient Q synthesis. Here, we further characterize this complex via immunoblotting and proteomic analysis of tandem affinity-purified tagged Coq proteins. We show that Coq8, a putative kinase required for the stability of the Q biosynthetic complex, is associated with a Coq6-containing complex. Additionally Q6 and late stage Q biosynthetic intermediates were also found to co-purify with the complex. A mitochondrial protein of unknown function, encoded by the YLR290C open reading frame, is also identified as a constituent of the complex and is shown to be required for efficient de novo Q biosynthesis. Given its effect on Q synthesis and its association with the biosynthetic complex, we propose that the open reading frame YLR290C be designated COQ11. PMID:25631044

  15. The first de novo non-mosaic 14q11.2q13.1 tetrasomy of paternal origin.

    PubMed

    Tomaszewska, Agnieszka; Behrendt, Jakub; Boter, Marjan; Wawrzkiewicz-Witkowska, Angelika; Bos, Marnix J; Podbiol-Palenta, Agnieszka; Godula-Stuglik, Urszula; Galjaard, Robert-Jan H; Srebniak, Malgorzata I

    2016-05-01

    Tetrasomy 14q11q13 is a very rare chromosome aberration. So far, only five patients with such an imbalance were described. All these patients had a de novo marker chromosome idic(14)(q13) leading to a partial tetrasomy of chromosome 14. We report on the first case of a de novo non-mosaic partial tetrasomy 14q resulted not from a marker chromosome, but from an inverted triplication on paternal chromosome 14, characterized by using FISH and SNP array. Our patient showed some anomalies described in tetrasomy 14q11q13 with striking presence of paternal UPD(14) features (blepharophimosis, small thorax, and joint contractures, developmental delay). This unique patient supports the hypothesis that 14q11q13 may contain imprinted gene(s) that contribute to the paternal UPD(14) features of joint contractures and/or blepharophimosis. This patient demonstrates the utility of parent of origin testing in patients with de novo chromosome 14 aberrations. Overdosage of 14q11.1q13.1 may cause some features related to UPD(14) phenotype. © 2016 Wiley Periodicals, Inc. PMID:26789739

  16. Cloning mammary cell cDNAs from 17q12-q23 using interspecific somatic cell hybrids and subtractive hybridization

    SciTech Connect

    Cerosaletti, K.M.; Shapero, M.H.; Fournier, R.E.K.

    1995-01-01

    We have cloned human genes that are encoded in the region 17q12-q23 and expressed in breast tissue using interspecific somatic cell hybrids and subtractive hybridization. Two mouse microcell hybrids containing fragments of human chromosome 17 with a nonoverlap region at 17q12-q23 were generated by microcell transfer. Radiolabeled cDNA was synthesized from the hybrid cell containing the 17q12-q23 interval and was subtracted with an excess of RNA from the hybrid cell lacking the interval. Resulting cDNA probes enriched for sequences from 17q12-q23 were used to screen a human premenopausal breast cDNA library, and 60 cDNAs were identified. Three of these cDNAs mapped to the hybrid cell nonoverlap region. These cDNAs were expressed in mammary epithelial cell hybrids, although none appeared to be breast-specific. Sequence analysis of the cDNAs revealed that clone 93A represents a previously unidentified gene, clone 98C has homology to an expressed sequence tag from goat mammary tissue, and clone 200A is identical to the human homologue of the Drosophila melanogaster flightless-I gene. These genes map outside a 1-cM region linked to early onset familial breast cancer but may be useful genetic markers in the 17q12-q23 region. 47 refs., 6 figs.

  17. Design and analysis of a high Q MEMS passive RF filter

    NASA Astrophysics Data System (ADS)

    Rathee, Vishal; Pande, Rajesh

    2016-04-01

    Over the past few years, significant growth has been observed in using MEMS based passive components in the RF microelectronics domain, especially in transceiver system. This is due to some excellent properties of the MEMS devices like low loss, low cost and excellent isolation. This paper presents a design of high performance MEMS passive band pass filter, consisting of L and C with improved quality factor and insertion loss less than the reported filters. In this paper we have presented a design of 2nd order band pass filter with 2.4GHz centre frequency and 83MHz bandwidth for Bluetooth application. The simulation results showed improved Q-factor of 34 and Insertion loss of 1.7dB to 1.9dB. The simulation results needs to be validated by fabricating the device, fabrication flow of which is also presented in the paper.

  18. Electrical apparatus lockout device

    DOEpatents

    Gonzales, Rick

    1999-01-01

    A simple lockout device for electrical equipment equipped with recessed power blades is described. The device comprises a face-plate (12) having a threaded member (14) attached thereto and apertures suitable for accommodating the power blades of a piece of electrical equipment, an elastomeric nose (16) abutting the face-plate having a hole for passage of the threaded member therethrough and power blade apertures in registration with those of the face-plate, a block (20) having a recess (34) in its forward face for receiving at least a portion of the hose, a hole therein for receiving the threaded member and an integral extension (26) extending from its rear face. A thumb screw (22) suitable for turning with the hands and having internal threads suitable for engaging the threaded member attached to the face-plate is inserted into a passage in the integral extension to engage the threaded member in such a fashion that when the device is inserted over the recessed power blades of a piece of electrical equipment and the thumb screw (22) tightened, the elastomeric nose (16) is compressed between the face-plate (12) and the block (20) forcing it to expand laterally thereby securing the device in the recess and precluding the accidental or intentional energization of the piece of equipment by attachment of a power cord to the recessed power blades. Means are provided in the interval extension and the thumb screw for the attachment of a locking device (46) which will satisfy OSHA standards.

  19. Spectral tailoring device

    DOEpatents

    Brager, H.R.; Schenter, R.E.; Carter, L.L.; Karnesky, R.A.

    1987-08-05

    A spectral tailoring device for altering the neutron energy spectra and flux of neutrons in a fast reactor thereby selectively to enhance or inhibit the transmutation rate of a target metrical to form a product isotope. Neutron moderators, neutron filters, neutron absorbers and neutron reflectors may be used as spectral tailoring devices. Depending on the intended use for the device, a member from each of these four classes of materials could be used singularly, or in combination, to provide a preferred neutron energy spectra and flux of the neutrons in the region of the target material. In one embodiment of the invention, an assembly is provided for enhancing the production of isotopes, such as cobalt 60 and gadolinium 153. In another embodiment of the invention, a spectral tailoring device is disposed adjacent a target material which comprises long lived or volatile fission products and the device is used to shift the neutron energy spectra and flux of neutrons in the region of the fission products to preferentially transmute them to produce a less volatile fission product inventory. 6 figs.

  20. LABORATORY EVALUATION OF THE DELTA Q TEST FOR DUCT LEAKAGE

    SciTech Connect

    ANDREWS,J.W.

    2003-05-01

    Using a residential-size duct system in a controlled laboratory setting, the repeatability and accuracy of the Delta Q test for air leakage in residential duct systems have been measured. More than 100 Delta Q tests were performed. These were compared with results using fan pressurization and also with results of a procedure (Delta Q Plus) that uses leakage hole-size information to select the leakage pressures to be used in the Delta Q algorithm. The average error in supply or return leakage for the fan-pressurization test was 6.4% of system fan flow. For the Delta Q test it was 3.4% of fan flow, while for Delta Q Plus it was 1.9% of fan flow.

  1. On the robustness of the q-Gaussian family

    NASA Astrophysics Data System (ADS)

    Sicuro, Gabriele; Tempesta, Piergiulio; Rodríguez, Antonio; Tsallis, Constantino

    2015-12-01

    We introduce three deformations, called α-, β- and γ-deformation respectively, of a N-body probabilistic model, first proposed by Rodríguez et al. (2008), having q-Gaussians as N → ∞ limiting probability distributions. The proposed α- and β-deformations are asymptotically scale-invariant, whereas the γ-deformation is not. We prove that, for both α- and β-deformations, the resulting deformed triangles still have q-Gaussians as limiting distributions, with a value of q independent (dependent) on the deformation parameter in the α-case (β-case). In contrast, the γ-case, where we have used the celebrated Q-numbers and the Gauss binomial coefficients, yields other limiting probability distribution functions, outside the q-Gaussian family. These results suggest that scale-invariance might play an important role regarding the robustness of the q-Gaussian family.

  2. Multiple carriers of Q noble gases in primitive meteorites

    NASA Astrophysics Data System (ADS)

    Marrocchi, Yves; Avice, Guillaume; Estrade, Nicolas

    2015-04-01

    The main carrier of primordial heavy noble gases in chondrites is thought to be an organic phase, known as phase Q, whose precise characterization has resisted decades of investigation. Indirect techniques have revealed that phase Q might be composed of two subphases, one of them associated with sulfide. Here we provide experimental evidence that noble gases trapped within meteoritic sulfides present chemically and thermally driven behavior patterns that are similar to Q gases. We therefore suggest that phase Q is likely composed of two subcomponents: carbonaceous phases and sulfides. In situ decay of iodine at concentration levels consistent with those reported for meteoritic sulfides can reproduce the 129Xe excess observed for Q gases relative to fractionated solar wind. We suggest that the Q-bearing sulfides formed at high temperature and could have recorded the conditions that prevailed in the chondrule-forming region(s).

  3. General monogamy of Tsallis q -entropy entanglement in multiqubit systems

    NASA Astrophysics Data System (ADS)

    Luo, Yu; Tian, Tian; Shao, Lian-He; Li, Yongming

    2016-06-01

    In this paper, we study the monogamy inequality of Tsallis q -entropy entanglement. We first provide an analytic formula of Tsallis q -entropy entanglement in two-qubit systems for 5/-√{13 } 2 ≤q ≤5/+√{13 } 2 . The analytic formula of Tsallis q -entropy entanglement in 2 ⊗d system is also obtained and we show that Tsallis q -entropy entanglement satisfies a set of hierarchical monogamy equalities. Furthermore, we prove the squared Tsallis q -entropy entanglement follows a general inequality in the qubit systems. Based on the monogamy relations, a set of multipartite entanglement indicators is constructed, which can detect all genuine multiqubit entangled states even in the case of N -tangle vanishes. Moreover, we study some examples in multipartite higher-dimensional system for the monogamy inequalities.

  4. Ground states of baryoleptonic Q-balls in supersymmetric models

    SciTech Connect

    Shoemaker, Ian M.; Kusenko, Alexander

    2008-10-01

    In supersymmetric generalizations of the standard model, all stable Q-balls are associated with some flat directions. We show that, if the flat direction has both the baryon number and the lepton number, the scalar field inside the Q-ball can deviate slightly from the flat direction in the ground state. We identify the true ground states of such nontopological solitons, including the electrically neutral and electrically charged Q-balls.

  5. Laser device and method

    SciTech Connect

    Myers, J. D.

    1985-06-25

    A simplified, relatively inexpensive laser device, wherein the laser elements are fixed in a body exoskeleton of electrical insulating material having a low coefficient of thermal expansion. The preferred embodiment includes a shotgun type laser filter having parallel bores which receive the laser flashlamp and laser rod in fixed relation in a body chamber. The reflector surrounds the laser filter and retains the filter within the body chamber. In the preferred method of this invention, several controlled lasing pulses are generated with each illumination pulse of the flashlamp, substantially increasing the efficiency of the laser device. The number of pulses is generally controlled by increasing the voltage to the flashlamp. The rapid multiple lasing pulses generate an elongated plasma in a fluid medium, such as the vitreous fluid body of an eye which makes the laser device extemely efficient for treating glaucoma and other medical treatments.

  6. Electrochromic optical switching device

    DOEpatents

    Lampert, C.M.; Visco, S.J.

    1992-08-25

    An electrochromic cell is disclosed which comprises an electrochromic layer, a polymerizable organo-sulfur layer which comprises the counter electrode of the structure, and an ionically conductive electronically insulating material which comprises the separator between the electrodes. In a preferred embodiment, both the separator and the organo-sulfur electrode (in both its charged and uncharged states) are transparent either to visible light or to the entire solar spectrum. An electrochromic device is disclosed which comprises such electrodes and separator encased in glass plates on the inner surface of each of which is formed a transparent electrically conductive film in respective electrical contact with the electrodes which facilitates formation of an external electrical connection or contact to the electrodes of the device to permit electrical connection of the device to an external potential source. 3 figs.

  7. Electrochromic optical switching device

    DOEpatents

    Lampert, Carl M.; Visco, Steven J.

    1992-01-01

    An electrochromic cell is disclosed which comprises an electrochromic layer, a polymerizable organo-sulfur layer which comprises the counter electrode of the structure, and an ionically conductive electronically insulating material which comprises the separator between the electrodes. In a preferred embodiment, both the separator and the organo-sulfur electrode (in both its charged and uncharged states) are transparent either to visible light or to the entire solar spectrum. An electrochromic device is disclosed which comprises such electrodes and separator encased in glass plates on the inner surface of each of which is formed a transparent electrically conductive film in respective electrical contact with the electrodes which facilitates formation of an external electrical connection or contact to the electrodes of the device to permit electrical connection of the device to an external potential source.

  8. Nonaqueous electrical storage device

    SciTech Connect

    McEwen, A.B.; Evans, D.A.; Blakley, T.J.; Goldman, J.L.

    1999-10-26

    An electrochemical capacitor is disclosed that features two, separated, high surface area carbon cloth electrodes sandwiched between two current collectors fabricated of a conductive polymer having a flow temperature greater than 130 C, the perimeter of the electrochemical capacitor being sealed with a high temperature gasket to form a single cell device. The gasket material is a thermoplastic stable at temperatures greater than 100 C, preferably a polyester or a polyurethane, and having a reflow temperature above 130 C but below the softening temperature of the current collector material. The capacitor packaging has good mechanical integrity over a wide temperature range, contributes little to the device equivalent series resistance (ESR), and is stable at high potentials. In addition, the packaging is designed to be easily manufacturable by assembly line methods. The individual cells can be stacked in parallel or series configuration to reach the desired device voltage and capacitance.

  9. Percutaneous connector device

    NASA Technical Reports Server (NTRS)

    Parsons, W. E. (Inventor)

    1976-01-01

    A device is reported for facilitating the passage of electrical signals from an external source through the skin of a patient to internal portions of the body such as muscles and nerves. The connector device includes a bio-compatible shell having an enlarged disk shaped portion for being implanted below the skin of the patient. The shell has a first and second electrically conductive post carried therein upon which a plug can be readily connected and disconnected. A modified form of the invention utilizes a unipolar connector that is adapted to be plugged into a shell implanted below the skin of a patient. Both of the connector devices are designed to be separated when a predetermined force is applied. This prevents excessive force from being applied to the implanted bio-compatible shell.

  10. Silicon Carbide Electronic Devices

    NASA Technical Reports Server (NTRS)

    Neudeck, P. G.

    2001-01-01

    The status of emerging silicon carbide (SiC) widebandgap semiconductor electronics technology is briefly surveyed. SiC-based electronic devices and circuits are being developed for use in high-temperature, high-power, and/or high-radiation conditions under which conventional semiconductors cannot function. Projected performance benefits of SiC electronics are briefly illustrated for several applications. However, most of these operational benefits of SiC have yet to be realized in actual systems, primarily owing to the fact that the growth techniques of SiC crystals are relatively immature and device fabrication technologies are not yet sufficiently developed to the degree required for widespread, reliable commercial use. Key crystal growth and device fabrication issues that limit the performance and capability of high-temperature and/or high-power SiC electronics are identified. The electrical and material quality differences between emerging SiC and mature silicon electronics technology are highlighted.

  11. Regenerative combustion device

    DOEpatents

    West, Phillip B.

    2004-03-16

    A regenerative combustion device having a combustion zone, and chemicals contained within the combustion zone, such as water, having a first equilibrium state, and a second combustible state. Means for transforming the chemicals from the first equilibrium state to the second combustible state, such as electrodes, are disposed within the chemicals. An igniter, such as a spark plug or similar device, is disposed within the combustion zone for igniting combustion of the chemicals in the second combustible state. The combustion products are contained within the combustion zone, and the chemicals are selected such that the combustion products naturally chemically revert into the chemicals in the first equilibrium state following combustion. The combustion device may thus be repeatedly reused, requiring only a brief wait after each ignition to allow the regeneration of combustible gasses within the head space.

  12. Graphene field emission devices

    SciTech Connect

    Kumar, S. Raghavan, S.; Duesberg, G. S.; Pratap, R.

    2014-09-08

    Graphene field emission devices are fabricated using a scalable process. The field enhancement factors, determined from the Fowler-Nordheim plots, are within few hundreds and match the theoretical predictions. The devices show high emission current density of ∼10 nA μm{sup −1} at modest voltages of tens of volts. The emission is stable with time and repeatable over long term, whereas the noise in the emission current is comparable to that from individual carbon nanotubes emitting under similar conditions. We demonstrate a power law dependence of emission current on pressure which can be utilized for sensing. The excellent characteristics and relative ease of making the devices promise their great potential for sensing and electronic applications.

  13. Ion manipulation device

    DOEpatents

    Anderson, Gordon A; Smith, Richard D; Ibrahim, Yehia M; Baker, Erin M

    2014-09-16

    An ion manipulation method and device is disclosed. The device includes a pair of substantially parallel surfaces. An array of inner electrodes is contained within, and extends substantially along the length of, each parallel surface. The device includes a first outer array of electrodes and a second outer array of electrodes. Each outer array of electrodes is positioned on either side of the inner electrodes, and is contained within and extends substantially along the length of each parallel surface. A DC voltage is applied to the first and second outer array of electrodes. A RF voltage, with a superimposed electric field, is applied to the inner electrodes by applying the DC voltages to each electrode. Ions either move between the parallel surfaces within an ion confinement area or along paths in the direction of the electric field, or can be trapped in the ion confinement area.

  14. Pendulum detector testing device

    DOEpatents

    Gonsalves, J.M.

    1997-09-30

    A detector testing device is described which provides consistent, cost-effective, repeatable results. The testing device is primarily constructed of PVC plastic and other non-metallic materials. Sensitivity of a walk-through detector system can be checked by: (1) providing a standard test object simulating the mass, size and material content of a weapon or other contraband, (2) suspending the test object in successive positions, such as head, waist and ankle levels, simulating where the contraband might be concealed on a person walking through the detector system; and (3) swinging the suspended object through each of the positions, while operating the detector system and observing its response. The test object is retained in a holder in which the orientation of the test device or target can be readily changed, to properly complete the testing requirements. 5 figs.

  15. Pendulum detector testing device

    DOEpatents

    Gonsalves, John M.

    1997-01-01

    A detector testing device which provides consistent, cost-effective, repeatable results. The testing device is primarily constructed of PVC plastic and other non-metallic materials. Sensitivity of a walk-through detector system can be checked by: 1) providing a standard test object simulating the mass, size and material content of a weapon or other contraband, 2) suspending the test object in successive positions, such as head, waist and ankle levels, simulating where the contraband might be concealed on a person walking through the detector system; and 3) swinging the suspended object through each of the positions, while operating the detector system and observing its response. The test object is retained in a holder in which the orientation of the test device or target can be readily changed, to properly complete the testing requirements.

  16. Sterilisation of implantable devices.

    PubMed

    Matthews, I P; Gibson, C; Samuel, A H

    1994-01-01

    The pathogenesis and rates of infection associated with the use of a wide variety of implantable devices are described. The multi-factorial nature of post-operative periprosthetic infection is outlined and the role of sterilisation of devices is explained. The resistance of bacterial spores is highlighted as a problem and a full description is given of the processes of sterilisation by heat, steam, ethylene oxide, low temperature steam and formaldehyde, ionising radiation and liquid glutaraldehyde. Sterility assurance and validation are discussed in the context of biological indicators and physical/chemical indicators. Adverse effects upon the material composition of devices and problems of process control are listed. Finally, possible optimisations of the ethylene oxide process and their potential significance to the field of sterilisation of implants is explored. PMID:10172076

  17. Conformal gripping device

    NASA Technical Reports Server (NTRS)

    Vranish, John M. (Inventor)

    2009-01-01

    The present invention relates to a conformal gripping device. In an embodiment of the present invention a conformal gripper device may be disclosed comprising a frame that includes an array of movable pins. The device may also include a roller locking and unlocking system within the frame. The system may comprise a pair of locking rollers for each row of gripper pins to facilitate locking and unlocking the array of gripper pins on a column-by-column basis. The system may also include a striker element that may force the locking rollers to roll along an angled roll surface to facilitate unlocking of the array of pins on a column-by-column basis. The system may further include an electromagnetic actuator or solenoid and permanent magnets to facilitate movement of the striker element and the locking rollers.

  18. Evaporative Cooling Membrane Device

    NASA Technical Reports Server (NTRS)

    Lomax, Curtis (Inventor); Moskito, John (Inventor)

    1999-01-01

    An evaporative cooling membrane device is disclosed having a flat or pleated plate housing with an enclosed bottom and an exposed top that is covered with at least one sheet of hydrophobic porous material having a thin thickness so as to serve as a membrane. The hydrophobic porous material has pores with predetermined dimensions so as to resist any fluid in its liquid state from passing therethrough but to allow passage of the fluid in its vapor state, thereby, causing the evaporation of the fluid and the cooling of the remaining fluid. The fluid has a predetermined flow rate. The evaporative cooling membrane device has a channel which is sized in cooperation with the predetermined flow rate of the fluid so as to produce laminar flow therein. The evaporative cooling membrane device provides for the convenient control of the evaporation rates of the circulating fluid by adjusting the flow rates of the laminar flowing fluid.

  19. Nonaqueous Electrical Storage Device

    DOEpatents

    McEwen, Alan B.; Evans, David A.; Blakley, Thomas J.; Goldman, Jay L.

    1999-10-26

    An electrochemical capacitor is disclosed that features two, separated, high surface area carbon cloth electrodes sandwiched between two current collectors fabricated of a conductive polymer having a flow temperature greater than 130.degree. C., the perimeter of the electrochemical capacitor being sealed with a high temperature gasket to form a single cell device. The gasket material is a thermoplastic stable at temperatures greater than 100.degree. C., preferably a polyester or a polyurethane, and having a reflow temperature above 130.degree. C. but below the softening temperature of the current collector material. The capacitor packaging has good mechanical integrity over a wide temperature range, contributes little to the device equivalent series resistance (ESR), and is stable at high potentials. In addition, the packaging is designed to be easily manufacturable by assembly line methods. The individual cells can be stacked in parallel or series configuration to reach the desired device voltage and capacitance.

  20. Double face sealing device

    NASA Technical Reports Server (NTRS)

    Weddendorf, Bruce C. (Inventor)

    1991-01-01

    A double face sealing device for mounting between two surfaces to provide an airtight and fluid-tight seal between a closure member bearing one of the surfaces and a structure or housing bearing the other surface which extends around the opening or hatchway to be closed. The double face sealing device includes a plurality of sections or segments mounted to one of the surfaces, each having a main body portion, a pair of outwardly extending and diverging, cantilever, spring arms, and a pair of inwardly extending and diverging, cantilever, spring arms, an elastomeric cover on the distal, free, ends of the outwardly extending and diverging spring arms, and an elastomeric cover on the distal, free, ends of the inwardly extending and diverging spring arms. The double face sealing device has application or use in all environments requiring a seal, but is particularly useful to seal openings or hatchways between compartments of spacecraft or aircraft.