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Sample records for quality control testing

  1. Quality Control of Competence Testing.

    ERIC Educational Resources Information Center

    Taylor, Douglas A.; Clayton, Roger B.

    1986-01-01

    The author describes the testing program designed to determine awarding of the Green Certificate to farming trainees in Alberta, Canada. The three parts of the test include (1) job-site testing, (2) regional test center testing, and (3) written examination. (CH)

  2. 7 CFR 58.335 - Quality control tests.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 3 2010-01-01 2010-01-01 false Quality control tests. 58.335 Section 58.335... Procedures § 58.335 Quality control tests. All milk, cream and related products are subject to inspection for quality and condition throughout each processing operation. Quality control tests shall be made on...

  3. 7 CFR 58.335 - Quality control tests.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 3 2011-01-01 2011-01-01 false Quality control tests. 58.335 Section 58.335... Procedures § 58.335 Quality control tests. All milk, cream and related products are subject to inspection for quality and condition throughout each processing operation. Quality control tests shall be made on...

  4. 7 CFR 58.928 - Quality control tests.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 3 2011-01-01 2011-01-01 false Quality control tests. 58.928 Section 58.928... Procedures § 58.928 Quality control tests. All dairy products and other ingredients shall be subject to inspection for quality and condition throughout each processing operation. Quality control tests shall...

  5. 7 CFR 58.928 - Quality control tests.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 3 2010-01-01 2010-01-01 false Quality control tests. 58.928 Section 58.928... Procedures § 58.928 Quality control tests. All dairy products and other ingredients shall be subject to inspection for quality and condition throughout each processing operation. Quality control tests shall...

  6. 7 CFR 58.642 - Quality control tests.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 3 2011-01-01 2011-01-01 false Quality control tests. 58.642 Section 58.642... Procedures § 58.642 Quality control tests. All mix ingredients shall be subject to inspection for quality and condition throughout each processing operation. Quality control tests shall be made on flow line samples...

  7. 7 CFR 58.642 - Quality control tests.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 3 2010-01-01 2010-01-01 false Quality control tests. 58.642 Section 58.642... Procedures § 58.642 Quality control tests. All mix ingredients shall be subject to inspection for quality and condition throughout each processing operation. Quality control tests shall be made on flow line samples...

  8. 21 CFR 640.56 - Quality control test for potency.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 7 2010-04-01 2010-04-01 false Quality control test for potency. 640.56 Section...) BIOLOGICS ADDITIONAL STANDARDS FOR HUMAN BLOOD AND BLOOD PRODUCTS Cryoprecipitate § 640.56 Quality control test for potency. (a) Quality control tests for potency of antihemophilic factor shall be...

  9. 21 CFR 640.56 - Quality control test for potency.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 7 2011-04-01 2010-04-01 true Quality control test for potency. 640.56 Section...) BIOLOGICS ADDITIONAL STANDARDS FOR HUMAN BLOOD AND BLOOD PRODUCTS Cryoprecipitate § 640.56 Quality control test for potency. (a) Quality control tests for potency of antihemophilic factor shall be...

  10. 7 CFR 58.733 - Quality control tests.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 3 2011-01-01 2011-01-01 false Quality control tests. 58.733 Section 58.733... Procedures § 58.733 Quality control tests. (a) Chemical analyses. The following chemical analyses shall be... pasteurization by means of the phosphatase test, as well as any other tests necessary to assure good...

  11. 7 CFR 58.442 - Laboratory and quality control tests.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 3 2010-01-01 2010-01-01 false Laboratory and quality control tests. 58.442 Section 58.442 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING... Service 1 Operations and Operating Procedures § 58.442 Laboratory and quality control tests. (a)...

  12. 7 CFR 58.442 - Laboratory and quality control tests.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 3 2014-01-01 2014-01-01 false Laboratory and quality control tests. 58.442 Section 58.442 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING... Service 1 Operations and Operating Procedures § 58.442 Laboratory and quality control tests. (a)...

  13. 7 CFR 58.442 - Laboratory and quality control tests.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 3 2013-01-01 2013-01-01 false Laboratory and quality control tests. 58.442 Section 58.442 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING... Service 1 Operations and Operating Procedures § 58.442 Laboratory and quality control tests. (a)...

  14. 7 CFR 58.733 - Quality control tests.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Procedures § 58.733 Quality control tests. (a) Chemical analyses. The following chemical analyses shall be performed in accordance with the appropriate edition of the Official Methods of Analysis of the AOAC as... Cheese Products Bearing USDA Official Identification...

  15. [Internal quality control for antimicrobial susceptibility test: an experience feedback].

    PubMed

    Vedy, Serge

    2012-01-01

    Internal quality control (IQC) position in antimicrobial susceptibility testing must be evaluated attentively before using. Ours S. aureus ATCC 25923 use during year 2011 has given precious information that can be useful for other laboratories. First, IQC should never be used before checking that all the realisation process steps are controlled. It will then appear that reagents are the most susceptible to give false results. That's what happens in 2.74% of antimicrobial susceptibility test. IQC is then useful to limit their clinical's impact. However, IQC use also shows that quality improvement will be difficult without industrial producer's involvement. PMID:22826843

  16. Stochastic Models of Quality Control on Test Misgrading.

    ERIC Educational Resources Information Center

    Wang, Jianjun

    Stochastic models are developed in this article to examine the rate of test misgrading in educational and psychological measurement. The estimation of inadvertent grading errors can serve as a basis for quality control in measurement. Limitations of traditional Poisson models have been reviewed to highlight the need to introduce new models using…

  17. Development and Testing of a Nuclear Quality Assurance/Quality Control Technician Curriculum. Final Report.

    ERIC Educational Resources Information Center

    Espy, John; And Others

    A project was conducted to field test selected first- and second-year courses in a postsecondary nuclear quality assurance/quality control (QA/QC) technician curriculum and to develop the teaching/learning modules for seven technical specialty courses remaining in the QA/QC technician curriculum. The field testing phase of the project involved the…

  18. (Quality control and nondestructive test procedures for welded products)

    SciTech Connect

    Childress, C.E.

    1990-11-09

    The International Institute of Welding is composed of some 600 technical experts from 36 countries. These individuals are divided by talent and personal interest into fifteen separate groups called Commissions, each with its own charter and goals. The title, and by inference the charter, of Commission V is : Quality Control and Quality Assurance of Welded Products. In pursuit of its charter Commission V has several subcommissions engaged in the development of drafts, procedures, and standards. Those documents subsequently considered suitable may be submitted to the International Organization for Standards (ISO), an organization similar to the American Society for Testing Materials, for acceptance as international standards. All ISO Procedures and standards which have been in effect for five years must undergo review by the initiating body. The results from review of five-year-old standards and procedures and the discussion of other documents proposed for international publication are presented.

  19. ITC Guidelines on Quality Control in Scoring, Test Analysis, and Reporting of Test Scores

    ERIC Educational Resources Information Center

    Allalouf, Avi

    2014-01-01

    The Quality Control (QC) Guidelines are intended to increase the efficiency, precision, and accuracy of the scoring, analysis, and reporting process of testing. The QC Guidelines focus on large-scale testing operations where multiple forms of tests are created for use on set dates. However, they may also be used for a wide variety of other testing…

  20. VERIFICATION TESTING OF AIR POLLUTION CONTROL TECHNOLOGY QUALITY MANAGEMENT PLAN

    EPA Science Inventory

    This document is the basis for quality assurance for the Air Pollution Control Technology Verification Center (APCT Center) operated under the U.S. Environmental Protection Agency (EPA). It describes the policies, organizational structure, responsibilities, procedures, and qualit...

  1. Quality Control, Testing and Deployment Results in NIF ICCS

    NASA Astrophysics Data System (ADS)

    Woodruff, John

    The strategy used to develop the NIF Integrated Computer Control System (ICCS) calls for incremental cycles of construction and formal test to deliver a total of 1 million lines of code. Each incremental release takes four to six months to implement specific functionality and culminates when offline tests conducted in the ICCS Integration and Test Facility verify functional, performance, and interface requirements. Tests are then repeated on line to confirm integrated operation in dedicated laser laboratories or ultimately in the NIF. Test incidents along with other change requests are recorded and tracked to closure by the software change control board (SCCB). Annual independent audits advise management on software process improvements. Extensive experience has been gained by integrating controls in the prototype laser preamplifier laboratory. The control system installed in the preamplifier lab contains five of the ten planned supervisory subsystems and seven of sixteen planned front-end processors (FEPs). Beam alignment, timing, diagnosis and laser pulse amplification up to 20 joules was tested through an automated series of shots. Other laboratories have provided integrated testing of six additional FEPs. Process measurements including earned-value, product size, and defect densities provide software project controls and generate confidence that the control system will be successfully deployed.

  2. Quality Assurance and Quality Control in Point-of-Care Testing.

    PubMed

    Newman, Ashleigh W; Behling-Kelly, Erica

    2016-03-01

    With advancements in the standard of care in veterinary medicine and instrument technology, performing in-house laboratory work on a variety of point-of-care instruments, ranging from glucometers to benchtop chemistry analyzers, has become increasingly commonplace. However, the ability of an instrument to perform a test does not guarantee that those results are accurate. Ensuring that your in-clinic laboratory is providing reliable data requires a comprehensive plan that encompasses both common sense practices aimed at preventing errors at each stage of the testing process, as well as standard operating procedures to validate and monitor analyzer performance. These 2 arms of the plan are known as quality assurance and quality control. Although these concepts are typically out of the comfort zone for veterinarians, just as the thought of business management may deter some veterinarians from practice ownership, it is not beyond the capabilities of veterinarians to learn, understand, and incorporate them into their practice. The objectives of this article are to convey the importance of quality assurance and quality control, walk you through the American Society for Veterinary Clinical Pathology guidelines on this topic, and provide direction to additional resources for further education on this topic, all with the focus on point-of-care testing in the in-clinic laboratory. PMID:27451043

  3. Internal quality control in point-of-care testing: where's the evidence?

    PubMed

    Holt, Helen; Freedman, Danielle B

    2016-03-01

    ISO 22870 standards require protocols for performance of internal quality control for all point-of-care testing devices and training of users in its theory and practice. However, the unique setting of point-of-care testing (i.e. processes conducted by non-scientific users) means that laboratory internal quality control programmes do not easily translate to point-of-care testing. In addition, while the evidence base for internal quality control within the laboratory has been increasing, the equivalent literature surrounding point-of-care testing is very limited. This has led to wide variation in what is considered acceptable practice for internal quality control at the point of care. Indeed, it has been demonstrated that internal quality control is an area of deficiency in point-of-care testing. Internal quality control protocols used at point-of-care testing should be defined based on risk management. The protocol will therefore be dependent on analyser complexity and availability of inbuilt system checks, the risk associated with release of an incorrect patient result as well as frequency of use. The emphasis should be on designing an effective internal quality control protocol as opposed to the inherent tendency of introducing high-frequency quality control. Typically a simple pass or fail criterion is used for internal quality control in point-of-care testing based on whether internal quality control results fall within assigned ranges. While simply taught, such criteria can require broad internal quality control ranges to decrease the probability of false rejection (also reducing the probability of error detection). Customized internal quality control ranges, two-tier acceptance systems and assay-specific internal quality control can be used to improve error detection rates. PMID:26486440

  4. Multileaf collimator performance monitoring and improvement using semiautomated quality control testing and statistical process control

    SciTech Connect

    Létourneau, Daniel McNiven, Andrea; Keller, Harald; Wang, An; Amin, Md Nurul; Pearce, Jim; Norrlinger, Bernhard; Jaffray, David A.

    2014-12-15

    Purpose: High-quality radiation therapy using highly conformal dose distributions and image-guided techniques requires optimum machine delivery performance. In this work, a monitoring system for multileaf collimator (MLC) performance, integrating semiautomated MLC quality control (QC) tests and statistical process control tools, was developed. The MLC performance monitoring system was used for almost a year on two commercially available MLC models. Control charts were used to establish MLC performance and assess test frequency required to achieve a given level of performance. MLC-related interlocks and servicing events were recorded during the monitoring period and were investigated as indicators of MLC performance variations. Methods: The QC test developed as part of the MLC performance monitoring system uses 2D megavoltage images (acquired using an electronic portal imaging device) of 23 fields to determine the location of the leaves with respect to the radiation isocenter. The precision of the MLC performance monitoring QC test and the MLC itself was assessed by detecting the MLC leaf positions on 127 megavoltage images of a static field. After initial calibration, the MLC performance monitoring QC test was performed 3–4 times/week over a period of 10–11 months to monitor positional accuracy of individual leaves for two different MLC models. Analysis of test results was performed using individuals control charts per leaf with control limits computed based on the measurements as well as two sets of specifications of ±0.5 and ±1 mm. Out-of-specification and out-of-control leaves were automatically flagged by the monitoring system and reviewed monthly by physicists. MLC-related interlocks reported by the linear accelerator and servicing events were recorded to help identify potential causes of nonrandom MLC leaf positioning variations. Results: The precision of the MLC performance monitoring QC test and the MLC itself was within ±0.22 mm for most MLC leaves

  5. 7 CFR 58.442 - Laboratory and quality control tests.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... analyses—(1) Milkfat and moisture. One sample shall be tested from each vat of the finished cheese to assure compliance with composition requirements. (2) Test method. Chemical analysis shall be made in accordance with the methods described in Official Methods of Analysis of the Association of...

  6. 7 CFR 58.523 - Laboratory and quality control tests.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... satisfactory composition, shelf-life and stability. (b) Frequency of sampling—(1) Microbiological. Samples of...) Test methods—(1) Microbiological. Microbiological determinations shall be made for coliform... Public Health Association. (2) Chemical. Chemical analysis shall be made in accordance with the...

  7. 7 CFR 58.523 - Laboratory and quality control tests.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... satisfactory composition, shelf-life and stability. (b) Frequency of sampling—(1) Microbiological. Samples of...) Test methods—(1) Microbiological. Microbiological determinations shall be made for coliform... Public Health Association. (2) Chemical. Chemical analysis shall be made in accordance with the...

  8. 7 CFR 58.523 - Laboratory and quality control tests.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... satisfactory composition, shelf-life and stability. (b) Frequency of sampling—(1) Microbiological. Samples of...) Test methods—(1) Microbiological. Microbiological determinations shall be made for coliform... Public Health Association. (2) Chemical. Chemical analysis shall be made in accordance with the...

  9. 7 CFR 58.523 - Laboratory and quality control tests.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... the finished product. Routine analyses shall be made on raw materials and finished product to assure... raw milk for testing shall be taken as prescribed in § 58.135. Representative samples shall be...

  10. 7 CFR 58.733 - Quality control tests.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... results. (1) Cheese. A representative sample of cheese used in the manufacture of pasteurized process cheese products shall have been tested prior to usage to determine its moisture and fat content. (2) Pasteurized process cheese products. As many samples shall be taken of the finished product direct from...

  11. 7 CFR 58.733 - Quality control tests.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... results. (1) Cheese. A representative sample of cheese used in the manufacture of pasteurized process cheese products shall have been tested prior to usage to determine its moisture and fat content. (2) Pasteurized process cheese products. As many samples shall be taken of the finished product direct from...

  12. 7 CFR 58.733 - Quality control tests.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... results. (1) Cheese. A representative sample of cheese used in the manufacture of pasteurized process cheese products shall have been tested prior to usage to determine its moisture and fat content. (2) Pasteurized process cheese products. As many samples shall be taken of the finished product direct from...

  13. Ultrasonic Testing, Aviation Quality Control (Advanced): 9227.03.

    ERIC Educational Resources Information Center

    Dade County Public Schools, Miami, FL.

    This unit of instruction covers the theory of ultrasonic sound, methods of applying soundwaves to test specimens and interpreting results, calibrating the ultrasonic equipment, and the use of standards. Study periods, group discussions, and extensive use of textbooks and training manuals are to be used. These are listed along with references and…

  14. 7 CFR 58.523 - Laboratory and quality control tests.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... satisfactory composition, shelf-life and stability. (b) Frequency of sampling—(1) Microbiological. Samples of... of finished cottage cheese and from each lot or batch of product used as an ingredient. For keeping...) Test methods—(1) Microbiological. Microbiological determinations shall be made for...

  15. Anticipated Effectiveness of Active Noise Control in Propeller Aircraft Interiors as Determined by Sound Quality Tests

    NASA Technical Reports Server (NTRS)

    Powell, Clemans A.; Sullivan, Brenda M.

    2004-01-01

    Two experiments were conducted, using sound quality engineering practices, to determine the subjective effectiveness of hypothetical active noise control systems in a range of propeller aircraft. The two tests differed by the type of judgments made by the subjects: pair comparisons in the first test and numerical category scaling in the second. Although the results of the two tests were in general agreement that the hypothetical active control measures improved the interior noise environments, the pair comparison method appears to be more sensitive to subtle changes in the characteristics of the sounds which are related to passenger preference.

  16. Flight-Test Validation and Flying Qualities Evaluation of a Rotorcraft UAV Flight Control System

    NASA Technical Reports Server (NTRS)

    Mettler, Bernard; Tuschler, Mark B.; Kanade, Takeo

    2000-01-01

    This paper presents a process of design and flight-test validation and flying qualities evaluation of a flight control system for a rotorcraft-based unmanned aerial vehicle (RUAV). The keystone of this process is an accurate flight-dynamic model of the aircraft, derived by using system identification modeling. The model captures the most relevant dynamic features of our unmanned rotorcraft, and explicitly accounts for the presence of a stabilizer bar. Using the identified model we were able to determine the performance margins of our original control system and identify limiting factors. The performance limitations were addressed and the attitude control system was 0ptimize.d for different three performance levels: slow, medium, fast. The optimized control laws will be implemented in our RUAV. We will first determine the validity of our control design approach by flight test validating our optimized controllers. Subsequently, we will fly a series of maneuvers with the three optimized controllers to determine the level of flying qualities that can be attained. The outcome enable us to draw important conclusions on the flying qualities requirements for small-scale RUAVs.

  17. Testing and Quality Assurance of the Control System During NIF Commissioning

    SciTech Connect

    Casavant, D; Carey, R; Cline, B; Lagin, L; Ludwigsen, P; Reddi, U; Van Arsdall, P

    2003-10-13

    The strategy used to develop the National Ignition Facility Integrated Computer Control System (NIF ICCS) calls for incremental cycles of construction and formal test to deliver nearly one million lines of code. Software releases that implement specific functionality are approved for deployment when offline tests conducted in the ICCS Integration and Test Facility verify functional, performance and interface requirements using test procedures derived from system requirements. At this stage of the project the controls team has delivered approximately 3/4 of the planned software by performing dozens of development and test cycles within offline test facilities and followed by online tests to confirm integrated operation in the NIF. Test incidents are recorded and tracked from development to successful deployment by the verification team, with hardware and software changes approved by the appropriate change control board. Project metrics are generated by the Software Quality Assurance manager and monitored by ICCS management. Test results are summarized and reported to responsible individuals and Project managers under a work authorization and permit process that assesses risk and evaluates control system upgrade readiness. NIF is well into the first phases of its laser commissioning program to characterize and operate the first four laser beams and target systems. The integrated control system has successfully fired over 100 coordinated shots into beam diagnostics and an initial set of target diagnostics in the 10-m diameter target chamber. Extensive experience has been gained by integrating controls in prototype laboratories and in the NIF. This paper will discuss NIF's software QC and QA processes, capabilities of offline test facilities, and metrics collection.

  18. A routine quality assurance test for CT automatic exposure control systems.

    PubMed

    Iball, Gareth R; Moore, Alexis C; Crawford, Elizabeth J

    2016-01-01

    The study purpose was to develop and validate a quality assurance test for CT automatic exposure control (AEC) systems based on a set of nested polymethylmethacrylate CTDI phantoms. The test phantom was created by offsetting the 16 cm head phantom within the 32 cm body annulus, thus creating a three part phantom. This was scanned at all acceptance, routine, and some nonroutine quality assurance visits over a period of 45 months, resulting in 115 separate AEC tests on scanners from four manufacturers. For each scan the longitudinal mA modulation pattern was generated and measurements of image noise were made in two annular regions of interest. The scanner displayed CTDIvol and DLP were also recorded. The impact of a range of AEC configurations on dose and image quality were assessed at acceptance testing. For systems that were tested more than once, the percentage of CTDIvol values exceeding 5%, 10%, and 15% deviation from baseline was 23.4%, 12.6%, and 8.1% respectively. Similarly, for the image noise data, deviations greater than 2%, 5%, and 10% from baseline were 26.5%, 5.9%, and 2%, respectively. The majority of CTDIvol and noise deviations greater than 15% and 5%, respectively, could be explained by incorrect phantom setup or protocol selection. Barring these results, CTDIvol deviations of greater than 15% from baseline were found in 0.9% of tests and noise deviations greater than 5% from baseline were found in 1% of tests. The phantom was shown to be sensitive to changes in AEC setup, including the use of 3D, longitudinal or rotational tube current modulation. This test methodology allows for continuing performance assessment of CT AEC systems, and we recommend that this test should become part of routine CT quality assurance programs. Tolerances of ± 15% for CTDIvol and ± 5% for image noise relative to baseline values should be used. PMID:27455490

  19. [Quality control dose calibrators].

    PubMed

    Montoza Aguado, M; Delgado García, A; Ramírez Navarro, A; Salgado García, C; Muros de Fuentes, M A; Ortega Lozano, S; Bellón Guardia, M E; Llamas Elvira, J M

    2004-01-01

    We have reviewed the legislation about the quality control of dose calibrator. The importance of verifying the correct work of these instruments, is fundamental in daily practice of radiopharmacy and nuclear medicine. The Spanish legislation establishes to include these controls as part of the quality control of radiopharmaceuticals, and the program of quality assurance in nuclear medicine. We have reviewed guides and protocols from international eminent organizations, summarizing the recommended tests and periodicity of them. PMID:15625064

  20. Quality control ranges for testing broth microdilution susceptibility of Flavobacterium columnare and F. psychrophilium to nine antimicrobials

    Technology Transfer Automated Retrieval System (TEKTRAN)

    A multi-laboratory broth microdilution method trial was performed to standardize the specialized test conditions required for fish pathogens Flavobacterium columnare and F. pyschrophilum. Nine laboratories tested the quality control (QC) strains Escherichia coli ATCC 25922 and Aeromonas salmonicid...

  1. Performance Assessment of Internal Quality Control (IQC) Products in Blood Transfusion Compatibility Testing in China

    PubMed Central

    Li, Jing-Jing; Gao, Qi; Liu, Zhi-Dong; Kang, Qiong-Hua; Hou, Yi-Jun; Zhang, Luo-Chuan; Hu, Xiao-Mei; Li, Jie; Zhang, Juan

    2015-01-01

    Internal quality control (IQC) is a critical component of laboratory quality management, and IQC products can determine the reliability of testing results. In China, given the fact that most blood transfusion compatibility laboratories do not employ IQC products or do so minimally, there is a lack of uniform and standardized IQC methods. To explore the reliability of IQC products and methods, we studied 697 results from IQC samples in our laboratory from 2012 to 2014. The results showed that the sensitivity and specificity of the IQCs in anti-B testing were 100% and 99.7%, respectively. The sensitivity and specificity of the IQCs in forward blood typing, anti-A testing, irregular antibody screening, and cross-matching were all 100%. The reliability analysis indicated that 97% of anti-B testing results were at a 99% confidence level, and 99.9% of forward blood typing, anti-A testing, irregular antibody screening, and cross-matching results were at a 99% confidence level. Therefore, our IQC products and methods are highly sensitive, specific, and reliable. Our study paves the way for the establishment of a uniform and standardized IQC method for pre-transfusion compatibility testing in China and other parts of the world. PMID:26488582

  2. Historical Data Analyses and Scientific Knowledge Suggest Complete Removal of the Abnormal Toxicity Test as a Quality Control Test

    PubMed Central

    Garbe, Joerg H O; Ausborn, Susanne; Beggs, Claire; Bopst, Martin; Joos, Angelika; Kitashova, Alexandra A; Kovbasenco, OLga; Schiller, Claus-Dieter; Schwinger, Martina; Semenova, Natalia; Smirnova, Lilia; Stodart, Fraser; Visalli, Thomas; Vromans, Lisette

    2014-01-01

    In the early 1900s, the abnormal toxicity test (ATT) was developed as an auxiliary means to ensure safe and consistent antiserum production. Today, the ATT is utilized as a quality control (QC) release test according to pharmacopoeial or other regulatory requirements. The study design has not been changed since around 1940. The evidence of abnormal toxicity testing as a prediction for harmful batches is highly questionable and lacks a scientific rationale. Numerous reviews of historical ATT results have revealed that no reliable conclusions can be drawn from this QC measure. Modern pharmaceutical manufacturers have thorough control of the manufacturing process and comply with good manufacturing practice rules. Contaminants are appropriately controlled by complying with the validated manufacturing processes and strict QC batch release confirming batch-to-batch consistency. Recognizing that product safety, efficacy, and stability can be ensured with strict QC measures, nowadays most regulatory authorities do not require the ATT for most product classes. In line with the replacement, reduction, and refinement (3Rs) initiative, the test requirement has been deleted from approximately 80 monographs of the European Pharmacopoeia and for the majority of product classes in the United States. For these reasons, it is recommended that the ATT should be consistently omitted world-wide and be removed from pharmacopoeias and other regulatory requirements. PMID:25209378

  3. Historical data analyses and scientific knowledge suggest complete removal of the abnormal toxicity test as a quality control test.

    PubMed

    Garbe, Joerg H O; Ausborn, Susanne; Beggs, Claire; Bopst, Martin; Joos, Angelika; Kitashova, Alexandra A; Kovbasenco, Olga; Schiller, Claus-Dieter; Schwinger, Martina; Semenova, Natalia; Smirnova, Lilia; Stodart, Fraser; Visalli, Thomas; Vromans, Lisette

    2014-11-01

    In the early 1900s, the abnormal toxicity test (ATT) was developed as an auxiliary means to ensure safe and consistent antiserum production. Today, the ATT is utilized as a quality control (QC) release test according to pharmacopoeial or other regulatory requirements. The study design has not been changed since around 1940. The evidence of abnormal toxicity testing as a prediction for harmful batches is highly questionable and lacks a scientific rationale. Numerous reviews of historical ATT results have revealed that no reliable conclusions can be drawn from this QC measure. Modern pharmaceutical manufacturers have thorough control of the manufacturing process and comply with good manufacturing practice rules. Contaminants are appropriately controlled by complying with the validated manufacturing processes and strict QC batch release confirming batch-to-batch consistency. Recognizing that product safety, efficacy, and stability can be ensured with strict QC measures, nowadays most regulatory authorities do not require the ATT for most product classes. In line with the replacement, reduction, and refinement (3Rs) initiative, the test requirement has been deleted from approximately 80 monographs of the European Pharmacopoeia and for the majority of product classes in the United States. For these reasons, it is recommended that the ATT should be consistently omitted world-wide and be removed from pharmacopoeias and other regulatory requirements. PMID:25209378

  4. VMAT linear accelerator commissioning and quality assurance: dose control and gantry speed tests.

    PubMed

    Barnes, Michael P; Rowshanfarzad, Pejman; Greer, Peter B

    2016-01-01

    In VMAT treatment delivery the ability of the linear accelerator (linac) to accurately control dose versus gantry angle is critical to delivering the plan correctly. A new VMAT test delivery was developed to specifically test the dose versus gantry angle with the full range of allowed gantry speeds and dose rates. The gantry-mounted IBA MatriXX with attached inclinometer was used in movie mode to measure the instantaneous relative dose versus gantry angle during the plan every 0.54 s. The results were compared to the expected relative dose at each gantry angle calculated from the plan. The same dataset was also used to compare the instantaneous gan-try speeds throughout the delivery compared to the expected gantry speeds from the plan. Measurements performed across four linacs generally show agreement between measurement and plan to within 1.5% in the constant dose rate regions and dose rate modulation within 0.1 s of the plan. Instantaneous gantry speed was measured to be within 0.11°/s of the plan (1 SD). An error in one linac was detected in that the nominal gantry speed was incorrectly calibrated. This test provides a practical method to quality-assure critical aspects of VMAT delivery including dose versus gantry angle and gantry speed control. The method can be performed with any detector that can acquire time-resolved dosimetric information that can be synchronized with a measurement of gantry angle. The test fulfils several of the aims of the recent Netherlands Commission on Radiation Dosimetry (NCS) Report 24, which provides recommendations for comprehensive VMAT quality assurance. PMID:27167282

  5. On the use of cyclostationary indicators in IC engine quality control by cold tests

    NASA Astrophysics Data System (ADS)

    Delvecchio, S.; D'Elia, G.; Dalpiaz, G.

    2015-08-01

    This paper addresses the use of first- and second-order cyclostationary (CS1 and CS2) tools to process the vibration signals picked up from internal combustion (IC) engines during cold tests. This type of analysis is needed in order to detect and diagnose irregular operations for quality control purposes. The effectiveness of indicators such as Mean Instantaneous Power (MIP), Degree of Cyclostationarity (DCSα) and Indicator of Cyclostationarity (ICSnx) in detecting assembly faults has been tested on real signals concerning three faulty conditions: inverted piston, connecting rod with incorrectly tightened screws, connecting rod without one bearing cap. In the past several authors have mainly used cyclostationary metrics for diagnostics purposes in rolling bearings and gear systems. Moreover, a signal model, qualitatively reproducing the features of actual cold test signals, has been formulated and used in order to preliminarily study the influence of signal parameters on the Indicators of Cyclostationarity. The results indicate that the cyclostationary tools - mainly CS2 tools - are effective in detecting and diagnosing all tested faulty conditions. In particular, indicator IC⌢S2x is highly sensitive to faults and it is suitable as pass/fail tool in quality control at the end of the engine assembly line. As a further second-order cyclostationary metric, the MIP is effective for detection, as well for fault identification, since it is able to localize regular and fault events within the engine cycle. In addition DCSα effectively characterizes the CS2 periodicities, giving the cyclic order distribution. Since these CS2 tools require a moderate computation cost, they can be considered ready for on-line industrial applications.

  6. 30 CFR 28.33 - Quality control test methods, equipment, and records; review by MSHA; revocation of approval.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... HEALTH ADMINISTRATION, DEPARTMENT OF LABOR TESTING, EVALUATION, AND APPROVAL OF MINING PRODUCTS FUSES FOR... methods, equipment, or records do not ensure effective quality control over the fuse for which...

  7. Analysis of wind-tunnel stability and control tests in terms of flying qualities of full-scale airplanes

    NASA Technical Reports Server (NTRS)

    Kayten, Gerald G

    1945-01-01

    The analysis of results of wind-tunnel stability and control tests of powered airplane models in terms of the flying qualities of full-scale airplanes is advocated. In order to indicated the topics upon which comments are considered desirable in the report of a wind-tunnel stability and control investigation and to demonstrate the nature of the suggested analysis, the present NACA flying-qualities requirements are discussed in relation to wind-tunnel tests. General procedures for the estimation of flying qualities from wind-tunnel tests are outlined.

  8. Quality Control Methods for Optimal BCR-ABL1 Clinical Testing in Human Whole Blood Samples

    PubMed Central

    Stanoszek, Lauren M.; Crawford, Erin L.; Blomquist, Thomas M.; Warns, Jessica A.; Willey, Paige F.S.; Willey, James C.

    2014-01-01

    Reliable breakpoint cluster region (BCR)–Abelson (ABL) 1 measurement is essential for optimal management of chronic myelogenous leukemia. There is a need to optimize quality control, sensitivity, and reliability of methods used to measure a major molecular response and/or treatment failure. The effects of room temperature storage time, different primers, and RNA input in the reverse transcription (RT) reaction on BCR-ABL1 and β-glucuronidase (GUSB) cDNA yield were assessed in whole blood samples mixed with K562 cells. BCR-ABL1 was measured relative to GUSB to control for sample loading, and each gene was measured relative to known numbers of respective internal standard molecules to control for variation in quality and quantity of reagents, thermal cycler conditions, and presence of PCR inhibitors. Clinical sample and reference material measurements with this test were concordant with results reported by other laboratories. BCR-ABL1 per 103 GUSB values were significantly reduced (P = 0.004) after 48-hour storage. Gene-specific primers yielded more BCR-ABL1 cDNA than random hexamers at each RNA input. In addition, increasing RNA inhibited the RT reaction with random hexamers but not with gene-specific primers. Consequently, the yield of BCR-ABL1 was higher with gene-specific RT primers at all RNA inputs tested, increasing to as much as 158-fold. We conclude that optimal measurement of BCR-ABL1 per 103 GUSB in whole blood is obtained when gene-specific primers are used in RT and samples are analyzed within 24 hours after blood collection. PMID:23541592

  9. Galactose-1-phosphate Uridyltransferase Dried Blood Spot Quality Control Materials for Newborn Screening Tests

    PubMed Central

    Adam, Barbara W.; Flores, Sharon R.; Hou, Yu; Allen, Todd W.; De Jesus, Victor R.

    2015-01-01

    Objectives We aimed to prepare dried-blood-spot (DBS) quality control (QC) materials for galactose-1-phosphate uridyltransferase (GALT), to evaluate their stability during storage and use, and to evaluate their performance in five DBS GALT test methods. Design and Methods We prepared and characterized GALT-normal and GALT-deficient DBS materials and compared GALT activities in DBSs after predetermined storage intervals at controlled temperatures and humidities. External evaluators documented the suitability of the DBS QC materials for use in five GALT test methods. Results GALT activity losses from DBSs stored in low (<30%) humidity for 14 days at 45°C, 35 days at 37°C, 91 days at room temperature, 182 days at 4°C, and 367 days at −20°C were 54%, 53%, 52% 23%, and 7% respectively. In paired DBSs stored in high humidity (>50%) for identical intervals, losses were: 45°C—68%; 37°C—79%; room temperature—72%, and 4°C—63%. GALT activities in DBSs stored at 4°C were stable throughout 19 excursions to room temperature. Twenty-five of 26 external evaluators, using five different GALT test methods, classified the GALT-deficient DBSs as “outside normal limits”. All evaluators classified the GALT-normal DBSs as “within normal limits”. Conclusions Most of the GALT activity loss from DBSs stored at elevated or room temperature was attributable to the effects of storage temperature. Most of the loss from DBSs stored at 4°C was attributable to the effects of elevated humidity. Loss from DBSs stored at −20°C was insignificant. The DBS materials were suitable for monitoring performance of all five GALT test methods. PMID:25528144

  10. Quality control review: implementing a scientifically based quality control system.

    PubMed

    Westgard, James O; Westgard, Sten A

    2016-01-01

    This review focuses on statistical quality control in the context of a quality management system. It describes the use of a 'Sigma-metric' for validating the performance of a new examination procedure, developing a total quality control strategy, selecting a statistical quality control procedure and monitoring ongoing quality on the sigma scale. Acceptable method performance is a prerequisite to the design and implementation of statistical quality control procedures. Statistical quality control can only monitor performance, and when properly designed, alert analysts to the presence of additional errors that occur because of unstable performance. A new statistical quality control planning tool, called 'Westgard Sigma Rules,' provides a simple and quick way for selecting control rules and the number of control measurements needed to detect medically important errors. The concept of a quality control plan is described, along with alternative adaptations of a total quality control plan and a risk-based individualized quality control plan. Finally, the ongoing monitoring of analytic performance and test quality are discussed, including determination of measurement uncertainty from statistical quality control data collected under intermediate precision conditions and bias determined from proficiency testing/external quality assessment surveys. A new graphical tool, called the Sigma Quality Assessment Chart, is recommended for demonstrating the quality of current examination procedures on the sigma scale. PMID:26150675

  11. Control of Cable Insulation Quality by Changing of Electrical Capacitance Per Unit During High Voltage Testing

    NASA Astrophysics Data System (ADS)

    Starikova, N. S.; Redko, V. V.; Vavilova, G. V.

    2016-01-01

    The paper describes the complex method of insulation quality control. It was found that electrical contact between bead chain electrodes and insulation surface can be provided by surface discharges along the entire length of the controlled zone. The pattern of electromagnetic field was developed by using Comsol Myltiphysics software.

  12. Metallurgy, Visual Inspection, Hardness and Liquid Penetrant Testing, Aviation Quality Control 2: 9227.01.

    ERIC Educational Resources Information Center

    Dade County Public Schools, Miami, FL.

    The course consists of the basic and simpler methods of inspecting and nondestructive testing of parts and materials to insure the quality and reliability of the finished product. The outline consists of six blocks totaling 135 hours: (1) defects in the metal ingot, (2) defects resulting from processing metals, (3) defects in metals in service,…

  13. 10 CFR 26.137 - Quality assurance and quality control.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false Quality assurance and quality control. 26.137 Section 26....137 Quality assurance and quality control. (a) Quality assurance program. Each licensee testing facility shall have a quality assurance program that encompasses all aspects of the testing...

  14. Commonly Practiced Quality Control and Quality Assurance Procedures for Gas Chromatography-Mass Spectrometry Analysis in Forensic Urine Drug-Testing Laboratories.

    PubMed

    Goldberger, B A; Huestis, M A; Wilkins, D G

    1997-12-01

    Forensic urine drug-testing laboratories operate in a prescribed scientific and administrative manner to ensure accurate test results. All specimens positive by an initial immunoassay test must be confirmed by gas chromatography/mass spectrometry (GC/MS). To provide adequate control and verification of these analytical processes, laboratories must implement appropriate policies and procedures to be used in routine practice. This review describes the following topics regarding GC/MS analyses: method validation, instrument performance, assay calibration, quality control, criteria for designating a positive test result, sample and batch acceptance criteria, and GC/MS data review. PMID:26269941

  15. Current practices in endotoxin and pyrogen testing in biotechnology. The Quality Assurance/Quality Control Task Group. Parenteral Drug Association

    SciTech Connect

    Not Available

    1990-01-01

    This article presents the results of a nationwide survey of the biotechnology industry regarding endotoxin and pyrogen testing and control. It identifies procedures and methods being used by biotechnology companies, and firms working with biotechnology products, in the testing for and detection of endotoxin and other pyrogenic substances. The review attempts to identify areas of commonality and standardization within the industry and includes topics for discussion at the end of the survey results.

  16. Dosimetric quality control of Eclipse treatment planning system using pelvic digital test object

    NASA Astrophysics Data System (ADS)

    Benhdech, Yassine; Beaumont, Stéphane; Guédon, Jeanpierre; Crespin, Sylvain

    2011-03-01

    Last year, we demonstrated the feasibility of a new method to perform dosimetric quality control of Treatment Planning Systems in radiotherapy, this method is based on Monte-Carlo simulations and uses anatomical Digital Test Objects (DTOs). The pelvic DTO was used in order to assess this new method on an ECLIPSE VARIAN Treatment Planning System. Large dose variations were observed particularly in air and bone equivalent material. In this current work, we discuss the results of the previous paper and provide an explanation for observed dose differences, the VARIAN Eclipse (Anisotropic Analytical) algorithm was investigated. Monte Carlo simulations (MC) were performed with a PENELOPE code version 2003. To increase efficiency of MC simulations, we have used our parallelized version based on the standard MPI (Message Passing Interface). The parallel code has been run on a 32- processor SGI cluster. The study was carried out using pelvic DTOs and was performed for low- and high-energy photon beams (6 and 18MV) on 2100CD VARIAN linear accelerator. A square field (10x10 cm2) was used. Assuming the MC data as reference, χ index analyze was carried out. For this study, a distance to agreement (DTA) was set to 7mm while the dose difference was set to 5% as recommended in the TRS-430 and TG-53 (on the beam axis in 3-D inhomogeneities). When using Monte Carlo PENELOPE, the absorbed dose is computed to the medium, however the TPS computes dose to water. We have used the method described by Siebers et al. based on Bragg-Gray cavity theory to convert MC simulated dose to medium to dose to water. Results show a strong consistency between ECLIPSE and MC calculations on the beam axis.

  17. Quality control of the analysis of histamine in fish by proficiency test

    NASA Astrophysics Data System (ADS)

    Evangelista, Warlley P.; Tette, Patrícia A. S.; Gloria, Maria Beatriz A.

    2015-01-01

    The analysis of histamine is required by the European Union for the importation of tuna and other Scombroid fish. The aim of this study was to investigate the quality of the analysis of histamine in fish, by means of reference material (RM) and of proficiency test (PT). Sample analysis carried out using RM provided 89.4% recovery. During the proficiency test, the histamine content of the sample was 311.9 mg/kg and the z-score was zero. These results assure the good performance of the laboratory in the analysis of histamine in fish, asuring reliability of results to clients.

  18. Implementation of basic quality control tests for malaria medicines in Amazon Basin countries: results for the 2005–2010 period

    PubMed Central

    2012-01-01

    Background Ensuring the quality of malaria medicines is crucial in working toward malaria control and eventual elimination. Unlike other validated tests that can assess all critical quality attributes, which is the standard for determining the quality of medicines, basic tests are significantly less expensive, faster, and require less skilled labour; yet, these tests provide reproducible data and information on several critical quality attributes, such as identity, purity, content, and disintegration. Visual and physical inspection also provides valuable information about the manufacturing and the labelling of medicines, and in many cases this inspection is sufficient to detect counterfeit medicines. The Promoting the Quality of Medicines (PQM) programme has provided technical assistance to Amazon Malaria Initiative (AMI) countries to implement the use of basic tests as a key screening mechanism to assess the quality of malaria medicines available to patients in decentralized regions. Methods Trained personnel from the National Malaria Control Programmes (NMCPs), often in collaboration with country’s Official Medicine Control Laboratory (OMCL), developed country- specific protocols that encompassed sampling methods, sample analysis, and data reporting. Sampling sites were selected based on malaria burden, accessibility, and geographical location. Convenience sampling was performed and countries were recommended to store the sampled medicines under conditions that did not compromise their quality. Basic analytical tests, such as disintegration and thin layer chromatography (TLC), were performed utilizing a portable mini-laboratory. Results Results were originally presented at regional meetings in a non-standardized format that lacked relevant medicines information. However, since 2008 information has been submitted utilizing a template specifically developed by PQM for that purpose. From 2005 to 2010, the quality of 1,663 malaria medicines from seven AMI countries

  19. Leukopak PBMC Sample Processing for Preparing Quality Control Material to Support Proficiency Testing Programs

    PubMed Central

    Garcia, Ambrosia; Keinonen, Sarah; Sanchez, Ana M.; Ferrari, Guido; Denny, Thomas N.; Moody, M. Anthony

    2014-01-01

    External proficiency testing programs designed to evaluate the performance of end-point laboratories involved in vaccine and therapeutic clinical trials form an important part of clinical trial quality assurance. Good Clinical Laboratory Practice (GCLP) guidelines recommend both assay validation and proficiency testing for assays being used in clinical trials, and such testing is facilitated by the availability of large numbers of well-characterized test samples. These samples can be distributed to laboratories participating in these programs and allow monitoring of laboratory performance over time and among participating sites when results are obtained with samples derived from a large master set. The leukapheresis procedure provides an ideal way to collect samples from participants that can meet the required number of cells to support these activities. The collection and processing of leukapheresis samples requires tight coordination between the clinical and laboratory teams to collect, process, and cryopreserve large number of samples within the established ideal time of ≤8 hours. Here, we describe our experience with a leukapheresis cryopreseration program that has been able to preserve the functionality of cellular subsets and that provides the sample numbers necessary to run an external proficiency testing program. PMID:24928650

  20. Quality Leadership and Quality Control

    PubMed Central

    Badrick, Tony

    2003-01-01

    Different quality control rules detect different analytical errors with varying levels of efficiency depending on the type of error present, its prevalence and the number of observations. The efficiency of a rule can be gauged by inspection of a power function graph. Control rules are only part of a process and not an end in itself; just as important are the trouble-shooting systems employed when a failure occurs. 'Average of patient normals' may develop as a usual adjunct to conventional quality control serum based programmes. Acceptable error can be based on various criteria; biological variation is probably the most sensible. Once determined, acceptable error can be used as limits in quality control rule systems. A key aspect of an organisation is leadership, which links the various components of the quality system. Leadership is difficult to characterise but its key aspects include trust, setting an example, developing staff and critically setting the vision for the organisation. Organisations also have internal characteristics such as the degree of formalisation, centralisation, and complexity. Medical organisations can have internal tensions because of the dichotomy between the bureaucratic and the shadow medical structures. PMID:18568046

  1. The space shuttle advanced solid rocket motor: Quality control and testing

    NASA Technical Reports Server (NTRS)

    1991-01-01

    The Congressional committees that authorize the activities of NASA requested that the National Research Council (NRC) review the testing and quality assurance programs for the Advanced Solid Rocket Motor (ASRM) program. The proposed ASRM design incorporates numerous features that are significant departures from the Redesigned Solid Rocket Motor (RSRM). The NRC review concentrated mainly on these features. Primary among these are the steel case material, welding rather than pinning of case factory joints, a bolted field joint designed to close upon firing the rocket, continuous mixing and casting of the solid propellant in place of the current batch processes, use of asbestos-free insulation, and a lightweight nozzle. The committee's assessment of these and other features of the ASRM are presented in terms of their potential impact on flight safety.

  2. Projection of controlled repeatable real-time moving targets to test and evaluate motion imagery quality

    NASA Astrophysics Data System (ADS)

    Scopatz, Stephen D.; Mendez, Michael; Trent, Randall

    2015-05-01

    The projection of controlled moving targets is key to the quantitative testing of video capture and post processing for Motion Imagery. This presentation will discuss several implementations of target projectors with moving targets or apparent moving targets creating motion to be captured by the camera under test. The targets presented are broadband (UV-VIS-IR) and move in a predictable, repeatable and programmable way; several short videos will be included in the presentation. Among the technical approaches will be targets that move independently in the camera's field of view, as well targets that change size and shape. The development of a rotating IR and VIS 4 bar target projector with programmable rotational velocity and acceleration control for testing hyperspectral cameras is discussed. A related issue for motion imagery is evaluated by simulating a blinding flash which is an impulse of broadband photons in fewer than 2 milliseconds to assess the camera's reaction to a large, fast change in signal. A traditional approach of gimbal mounting the camera in combination with the moving target projector is discussed as an alternative to high priced flight simulators. Based on the use of the moving target projector several standard tests are proposed to provide a corresponding test to MTF (resolution), SNR and minimum detectable signal at velocity. Several unique metrics are suggested for Motion Imagery including Maximum Velocity Resolved (the measure of the greatest velocity that is accurately tracked by the camera system) and Missing Object Tolerance (measurement of tracking ability when target is obscured in the images). These metrics are applicable to UV-VIS-IR wavelengths and can be used to assist in camera and algorithm development as well as comparing various systems by presenting the exact scenes to the cameras in a repeatable way.

  3. 40 CFR 51.359 - Quality control.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 2 2010-07-01 2010-07-01 false Quality control. 51.359 Section 51.359....359 Quality control. Quality control measures shall insure that emission testing equipment is... quality control frequencies by using statistical process control to monitor equipment performance on...

  4. QUALITY CONTROLS FOR PCR

    EPA Science Inventory

    The purpose of this presentation is to present an overview of the quality control (QC) sections of a draft EPA document entitled, "Quality Assurance/Quality Control Guidance for Laboratories Performing PCR Analyses on Environmental Samples." This document has been prepared by th...

  5. 10 CFR 26.137 - Quality assurance and quality control.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 1 2011-01-01 2011-01-01 false Quality assurance and quality control. 26.137 Section 26.137 Energy NUCLEAR REGULATORY COMMISSION FITNESS FOR DUTY PROGRAMS Licensee Testing Facilities § 26.137 Quality assurance and quality control. (a) Quality assurance program. Each licensee...

  6. 10 CFR 26.137 - Quality assurance and quality control.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 1 2013-01-01 2013-01-01 false Quality assurance and quality control. 26.137 Section 26.137 Energy NUCLEAR REGULATORY COMMISSION FITNESS FOR DUTY PROGRAMS Licensee Testing Facilities § 26.137 Quality assurance and quality control. (a) Quality assurance program. Each licensee...

  7. Radiographic quality control devices.

    PubMed

    2000-04-01

    In this study, we evaluate eight radiographic quality control (QC) devices, which noninvasively measure the output from a variety of diagnostic x-ray production systems. When used as part of a quality assurance (QA) program, radiographic QC devices help ensure that x-ray equipment is working within acceptable limits. This in turn helps ensure that high-quality images are achieved with appropriate radiation doses and that resources are used efficiently (for example, by minimizing the number of repeat exposures required). Our testing focused on the physical performance, ease of use, and service and maintenance characteristics that affect the use of these devices for periodic, routine measurements of x-ray system parameters. We found that all the evaluated models satisfactorily measure all the parameters normally needed for a QA program. However, we did identify a number of differences among the models--particularly in the range of exposure levels that can be effectively measured and the ease of use. Three models perform well for a variety of applications and are very easy to use; we rate them Preferred. Three additional models have minor limitations but otherwise perform well; we rate them Acceptable. We recommend against purchasing two models because, although each performs acceptably for most applications, neither model can measure low levels of radiation. This Evaluation covers devices designed to measure the output of x-ray tubes noninvasively. These devices, called radiographic quality control (QC) devices, or QC meters, are typically used by medical physicists, x-ray engineers, biomedical engineers, and suitably trained radiographic technologists to make QC measurements. We focus on the use of these devices as part of an overall quality assurance (QA) program. We have not evaluated their use for other applications, such as acceptance testing. To be included in this study, a device must be able to measure the exposure- and kVp-related characteristics of most x

  8. Applicability of the Monocyte Activation Test (MAT) for hyperimmune sera in the routine of the quality control laboratory: Comparison with the Rabbit Pyrogen Test (RPT).

    PubMed

    da Silva, Cristiane Caldeira; Presgrave, Octavio Augusto França; Hartung, Thomas; de Moraes, Aurea Maria Lage; Delgado, Isabella Fernandes

    2016-04-01

    Pyrogen tests are safety assays performed during the routine quality control of injectable products required by regulatory agencies. Currently, there are three available testing possibilities: 1) the Rabbit Pyrogen Test (RPT); 2) the Bacterial Endotoxin Test (BET); and 3) test systems using human whole-blood or monocytes, termed Monocyte Activation Test (MAT). Although BET is often considered as a replacement for the animal test, it is unable to detect pyrogens other than endotoxin. MAT is based on the human fever reaction and thus, most closely reflects the human response. The aim of this study was to conduct a parallel comparison of the RPT and MAT for hyperimmune sera (HS) batches analyzed during the routine of a quality control laboratory. MAT was performed in the same 43 batches of HS previously tested using RPT. The results showed that MAT presented 100% sensitivity and approximately 85% specificity as compared to RPT, i.e., no false-negative results were obtained. Few suspicious samples, which were negative in the RPT after retesting, provided divergent positive results suggesting a lower limit of detection of MAT. MAT is thus able to detect contaminants in biological products such as HS batches. PMID:26688320

  9. 40 CFR 51.359 - Quality control.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ....359 Quality control. Quality control measures shall insure that emission testing equipment is... 40 Protection of Environment 2 2013-07-01 2013-07-01 false Quality control. 51.359 Section 51.359... of tests) which fall into the testing categories identified. Alternatives or exceptions to...

  10. 40 CFR 51.359 - Quality control.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ....359 Quality control. Quality control measures shall insure that emission testing equipment is... 40 Protection of Environment 2 2014-07-01 2014-07-01 false Quality control. 51.359 Section 51.359... of tests) which fall into the testing categories identified. Alternatives or exceptions to...

  11. 40 CFR 51.359 - Quality control.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ....359 Quality control. Quality control measures shall insure that emission testing equipment is... 40 Protection of Environment 2 2012-07-01 2012-07-01 false Quality control. 51.359 Section 51.359... of tests) which fall into the testing categories identified. Alternatives or exceptions to...

  12. A flight cylinder bioassay as a simple, effective quality control test for Cydia pomonella

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Assessment of quality of the sterile male insects that are being mass-reared for release in area-wide integrated pest management programmes that include a sterile insect technique component is crucial for the success of these programmes. Routine monitoring of sterile male quality needs to be carried...

  13. Eddy Current, Magnetic Particle and Hardness Testing, Aviation Quality Control (Advanced): 9227.04.

    ERIC Educational Resources Information Center

    Dade County Public Schools, Miami, FL.

    This unit of instruction includes the principles of eddy current, magnetic particle and hardness testing; standards used for analyzing test results; techniques of operating equipment; interpretation of indications; advantages and limitations of these methods of testing; care and calibration of equipment; and safety and work precautions. Motion…

  14. 40 CFR 136.7 - Quality assurance and quality control.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 23 2014-07-01 2014-07-01 false Quality assurance and quality control. 136.7 Section 136.7 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS (CONTINUED) GUIDELINES ESTABLISHING TEST PROCEDURES FOR THE ANALYSIS OF POLLUTANTS § 136.7 Quality assurance and quality control. The...

  15. Hypoosmotic swelling test for quality control of sperm prepared for assisted reproduction.

    PubMed

    Mladenović, I; Mićić, S; Genbaćev, O; Papić, N

    1995-01-01

    This study evaluates the clinical usefulness of one additional parameter for assessment of human sperm cell function in vitro--the hypoosmotic swelling test. The hypoosmotic swelling test evaluated the functional integrity of the sperm plasma membrane. The investigation included a comparison of the hypoosmotic swelling test in samples containing motile and immotile spermatozoa and their correlation with the intrauterine insemination outcome. Motile spermatozoa expressed better membrane characteristics, without any importance of the hypoosmotic conditions. Positive correlation exists between HOS results and the outcome of IUI. This test can be a useful addition to the standard battery of semen analyzing tests. PMID:7625880

  16. Quality control guidelines for disk diffusion and broth microdilution antimicrobial susceptibility tests with seven drugs for veterinary applications.

    PubMed

    Odland, B A; Erwin, M E; Jones, R N

    2000-01-01

    This multicenter study proposes antimicrobial susceptibility (MIC and disk diffusion methods) quality control (QC) parameters for seven compounds utilized in veterinary health. Alexomycin, apramycin, tiamulin, tilmicosin, and tylosin were tested by broth microdilution against various National Committee for Clinical Laboratory Standards (NCCLS)-recommended QC organisms (Staphylococcus aureus ATCC 29213, Enterococcus faecalis ATCC 29212, Streptococcus pneumoniae ATCC 49619, Escherichia coli ATCC 25922, and Pseudomonas aeruginosa ATCC 27853). In addition, disk diffusion zone diameter QC limits were determined for apramycin, enrofloxacin, and premafloxacin by using E. coli ATCC 25922, P. aeruginosa ATCC 27853, and S. aureus ATCC 25923. The results from five or six participating laboratories produced >/=99.0% of MICs and >/=95.0% of the zone diameters within suggested guidelines. The NCCLS Subcommittee for Veterinary Antimicrobial Susceptibility Testing has recently approved these ranges for publication in the next M31 document. PMID:10618141

  17. Radiographic and Thermal Testing, Aviation Quality Control (Advanced): 9227.02.

    ERIC Educational Resources Information Center

    Dade County Public Schools, Miami, FL.

    This unit of instruction deals with the study of X-ray and Gamma Ray Radiographic Testing and infra-red thermal testing of specimens without destruction. Theory and principles are covered in detail. Many known samples are used as standards and considerable laboratory and field use of this equipment is involved. Motion picture films and color…

  18. 46 CFR 160.115-15 - Production inspections, tests, quality control, and conformance of winches.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... inspection in 46 CFR part 159, subpart 159.007 and in this section, unless the Commandant authorizes alternative tests and inspections. The Commandant may prescribe additional production tests and inspections... of this subpart. (c) Recordkeeping. The manufacturer must maintain records in accordance with 46...

  19. 46 CFR 160.115-15 - Production inspections, tests, quality control, and conformance of winches.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... inspection in 46 CFR part 159, subpart 159.007 and in this section, unless the Commandant authorizes alternative tests and inspections. The Commandant may prescribe additional production tests and inspections... of this subpart. (c) Recordkeeping. The manufacturer must maintain records in accordance with 46...

  20. 46 CFR 160.132-15 - Production inspections, tests, quality control, and conformance of davits.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... inspection in 46 CFR part 159, subpart 159.007 and in this section, unless the Commandant authorizes alternative tests and inspections. The Commandant may prescribe additional production tests and inspections... of this subpart. (c) Recordkeeping. The manufacturer must maintain records in accordance with 46...

  1. 46 CFR 160.132-15 - Production inspections, tests, quality control, and conformance of davits.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... inspection in 46 CFR part 159, subpart 159.007 and in this section, unless the Commandant authorizes alternative tests and inspections. The Commandant may prescribe additional production tests and inspections... of this subpart. (c) Recordkeeping. The manufacturer must maintain records in accordance with 46...

  2. Magnetic system for the quality control of specimens for Charpy impact test

    NASA Astrophysics Data System (ADS)

    Martin, R. V.; Castanho, M. A. P.

    2015-10-01

    It was developed a non-destructive testing system based on magnetic methods for characterization of steel specimens, used in calibration of Charpy impact testing machines. The magnetic properties saturation, remanence, coercivity, and the hysteresis curves were used to create a "magnetic signature" of reference to ensure the value of energy absorbed by these standard specimens.

  3. 40 CFR 51.359 - Quality control.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 2 2011-07-01 2011-07-01 false Quality control. 51.359 Section 51.359....359 Quality control. Quality control measures shall insure that emission testing equipment is calibrated and maintained properly, and that inspection, calibration records, and control charts...

  4. 46 CFR 160.170-15 - Production inspections, tests, quality control, and conformance of release mechanisms.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... with the procedures for independent laboratory inspection in 46 CFR part 159, subpart 159.007 and in this section unless the Commandant authorizes alternative tests and inspections. The Commandant may...) Recordkeeping. The manufacturer must maintain records in accordance with 46 CFR 159.007-13. The...

  5. 46 CFR 160.133-15 - Production inspections, tests, quality control, and conformance of release mechanisms.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... with the procedures for independent laboratory inspection in 46 CFR part 159, subpart 159.007 and in this section, unless the Commandant authorizes alternative tests and inspections. The Commandant may... subpart. (c) Recordkeeping. The manufacturer must maintain records in accordance with 46 CFR...

  6. 46 CFR 160.133-15 - Production inspections, tests, quality control, and conformance of release mechanisms.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... out in accordance with the procedures for independent laboratory inspection in 46 CFR part 159, subpart 159.007 and in this section, unless the Commandant authorizes alternative tests and inspections... subpart. (c) Recordkeeping. The manufacturer must maintain records in accordance with 46 CFR...

  7. 46 CFR 160.170-15 - Production inspections, tests, quality control, and conformance of release mechanisms.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... with the procedures for independent laboratory inspection in 46 CFR part 159, subpart 159.007 and in this section unless the Commandant authorizes alternative tests and inspections. The Commandant may...) Recordkeeping. The manufacturer must maintain records in accordance with 46 CFR 159.007-13. The...

  8. 46 CFR 160.135-15 - Production inspections, tests, quality control, and conformance of lifeboats.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... CFR part 159, subpart 159.007 and in this section, unless the Commandant authorizes alternative tests... CFR 159.007-13. The manufacturer must keep records of all items listed in this section for at least 5... this subpart, other CFR sections referenced in this subpart, and each applicable document listed...

  9. 46 CFR 160.135-15 - Production inspections, tests, quality control, and conformance of lifeboats.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... CFR part 159, subpart 159.007 and in this section, unless the Commandant authorizes alternative tests... CFR 159.007-13. The manufacturer must keep records of all items listed in this section for at least 5... this subpart, other CFR sections referenced in this subpart, and each applicable document listed...

  10. 46 CFR 160.135-15 - Production inspections, tests, quality control, and conformance of lifeboats.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... CFR part 159, subpart 159.007 and in this section, unless the Commandant authorizes alternative tests... CFR 159.007-13. The manufacturer must keep records of all items listed in this section for at least 5... this subpart, other CFR sections referenced in this subpart, and each applicable document listed...

  11. Melatonin controlled apoptosis and protected the testes and sperm quality against bisphenol A-induced oxidative toxicity.

    PubMed

    Othman, Azza I; Edrees, Gamal M; El-Missiry, Mohamed A; Ali, Doaa A; Aboel-Nour, Mohamed; Dabdoub, Banan R

    2016-09-01

    Epidemiological reports have indicated a correlation between the increasing bisphenol A (BPA) levels in the environment and the incidence of male infertility. In this study, the protective effects of melatonin on BPA-induced oxidative stress and apoptosis were investigated in the rat testes and epididymal sperm. Melatonin (10 mg/kg body weight (bw)) was injected concurrently with BPA (50 mg/kg bw) for 3 and 6 weeks. The administration of BPA significantly increased oxidative stress in the testes and epididymal sperm. This was associated with a decrease in the serum testosterone level as well as sperm quality, chromatin condensation/de-condensation level, and the percentage of haploid germ cells in the semen. BPA administration caused a significant increase in apoptosis accompanied by a decrease in the expression of the antiapoptotic proteins Bcl-2 in the testes and epididymal sperm. The concurrent administration of melatonin decreased oxidative stress by modulating the levels of glutathione, superoxide dismutase, and catalase as well as the malondialdehyde and hydrogen peroxide concentrations in the testes and sperm. Melatonin sustained Bcl-2 expression and controlled apoptosis. Furthermore, melatonin maintained the testosterone levels, ameliorated histopathological changes, increased the percentages of seminal haploid germ cells, and protected sperm chromatin condensation process, indicating appropriate spermatogenesis with production of functional sperm. In conclusion, melatonin protected against BPA-induced apoptosis by controlling Bcl-2 expression and ameliorating oxidative stress in the testes and sperm. Thus, melatonin is a promising pharmacological agent for preventing the potential reproductive toxicity of BPA following occupational or environmental exposures. PMID:25537623

  12. Essential elements of quality control.

    PubMed

    Boylan, J C

    1983-11-01

    The components of quality control in the pharmaceutical industry are discussed as they apply to hospital pharmacy admixture services. The pharmaceutical industry complies with the FDA's Current Good Manufacturing Practices, which require manufacturers to have written procedures for ensuring sterility and nonpyrogenicity of injectable products. Because FDA specifies only what outcome measures must be assessed (rather than specific means of assessment), pharmaceutical companies have developed a multiplicity of quality-control systems. However, each system consists of a master formula (quantitative listing of all ingredients), master manufacturing instructions (the recipe for each product), master packaging instructions, and batch records. Documents used by quality control personnel include the specifications (identification, tests, and limits for products), test methods, and sampling procedures. Hospitals should have similar quality-control programs. These programs should systematically prevent or identify and correct deficiencies, measure overall quality, and provide information for managers. Hospital pharmacists whose departments do not have comprehensive programs should consult colleagues who have developed such procedures. Techniques used in industry should be applied when possible. To protect the integrity of manufacturers' drug products during compounding in hospitals, every hospital admixture service must have its own quality-control system. PMID:6650523

  13. Quality control and analytical test method for Taxus baccata tincture preparation.

    PubMed

    Vignolini, Pamela; Gehrmann, Beatrice; Melzig, Matthias Friedrich; Borsacchi, Leonardo; Scardigli, Arianna; Romani, Annalisa

    2012-07-01

    The homeopathic tincture of Taxus baccata L. is monographed in the current German Homeopathic Pharmacopoeia (HAB 2009). However, the described identification test is a common comparative TLC procedure that might be updated. The purpose of the current work was the quali-quantitative analysis by HPLC/DAD/MS of Taxus tincture. In this study we characterized polyphenolic compounds, in particular four hydroxycinnamic derivatives (0.85 mg/mL) and four flavonoids (quercetin and kaempferol 3-O-rutinoside and xylosyl glucosides); the total polyphenol content was 1.265 mg/mL of tincture. Starting from the official German Homeopathic Pharmacopoeia method of preparation, the aim of this work was to optimize a rapid and reproducible method for the analysis of herbal drugs and tincture, directly prepared in store or the herbalist's shop, to ensure safety and efficacy of the preparation. The procedure has to ensure validation, robustness of the results, and provide a quick response about the composition of compounds in the herbal drug preparation. PMID:22908569

  14. The QCRad Value Added Product: Surface Radiation Measurement Quality Control Testing, Including Climatology Configurable Limits

    SciTech Connect

    Long, CN; Shi, Y

    2006-09-01

    This document describes the QCRad methodology, which uses climatological analyses of the surface radiation measurements to define reasonable limits for testing the data for unusual data values. The main assumption is that the majority of the climatological data are “good” data, which for field sites operated with care such as those of the Atmospheric Radiation Measurement (ARM) Program is a reasonable assumption. Data that fall outside the normal range of occurrences are labeled either “indeterminate” (meaning that the measurements are possible, but rarely occurring, and thus the values cannot be identified as good) or “bad” depending on how far outside the normal range the particular data reside. The methodology not only sets fairly standard maximum and minimum value limits, but also compares what we have learned about the behavior of these instruments in the field to other value-added products (VAPs), such as the Diffuse infrared (IR) Loss Correction VAP (Younkin and Long 2004) and the Best Estimate Flux VAP (Shi and Long 2002).

  15. A CD-ROM prototype of a multimedia-based interactive tool and guide, to perform quality control tests for the computed tomography scanners.

    PubMed

    Perris, A; Pateras, K; Rizopoulos, D; Skourlas, C; Maris, T

    1996-01-01

    Quality control tests for CT scanners are very important for correct machine performance, and for the radiation protection of patients and medical personnel. As proliferation of CT scanners continues, the need for distributable software tools to perform quality control tests becomes evident. A multimedia tool and guide will help medical physicists and technologists to perform these tests easily and correctly. The guide can be easily accessible in CD-ROM, or networked on the Internet. The user, medical physicist or technologist, can find in the present guide the pertinent theoretical information and the procedures necessary to perform the quality control tests, with the help of texts, CT images and photographs, narration and video. The results of the tests are automatically compared with machine specifications and acceptable values set by international bodies, and are stored in a table. PMID:8947894

  16. Instrument Quality Control.

    PubMed

    Jayakody, Chatura; Hull-Ryde, Emily A

    2016-01-01

    Well-defined quality control (QC) processes are used to determine whether a certain procedure or action conforms to a widely accepted standard and/or set of guidelines, and are important components of any laboratory quality assurance program (Popa-Burke et al., J Biomol Screen 14: 1017-1030, 2009). In this chapter, we describe QC procedures useful for monitoring the accuracy and precision of laboratory instrumentation, most notably automated liquid dispensers. Two techniques, gravimetric QC and photometric QC, are highlighted in this chapter. When used together, these simple techniques provide a robust process for evaluating liquid handler accuracy and precision, and critically underpin high-quality research programs. PMID:27316990

  17. Systems Engineering, Quality and Testing

    NASA Technical Reports Server (NTRS)

    Shepherd, Christena C.

    2015-01-01

    AS9100 has little to say about how to apply a Quality Management System (QMS) to aerospace test programs. There is little in the quality engineering Body of Knowledge that applies to testing, unless it is nondestructive examination or some type of lab or bench testing. If one examines how the systems engineering processes are implemented throughout a test program; and how these processes can be mapped to AS9100, a number of areas for involvement of the quality professional are revealed.

  18. The International Interlaboratory Quality Control Program for Measurement of Antiretroviral Drugs in Plasma: a global proficiency testing program.

    PubMed

    Burger, David; Teulen, Marga; Eerland, Jaco; Harteveld, Anneke; Aarnoutse, Rob; Touw, Daan

    2011-04-01

    The International Interlaboratory Quality Control Program for Measurement of Antiretroviral Drugs in Plasma was initiated in 1999 by Radboud University Nijmegen Medical Center, The Netherlands, and continued later on in collaboration with the Dutch Association for Quality Assessment in Therapeutic Drug Monitoring and Clinical Toxicology (www.kkgt.nl). The aim of this analysis was to evaluate the first 10 years of the Program and to determine variables associated with reporting of less accurate results. Two rounds are organized annually in which blind samples are shipped to participants containing a low, medium, or high concentration of each antiretroviral drug. Any reported result that deviates more than 20% from the spiked concentration is defined as inaccurate. By the end of 2009, the number of laboratories participating in the Program had increased to 56; 44 (79%) are located in Europe. A total of 12,798 test results was available for analysis, of which 2104 (16.4%) were reported as inaccurate. Performance was best for samples containing nevirapine (mean of inadequate scores per round: 11.1%) and lopinavir (11.9%) and worst for indinavir (18.7%), atazanavir (18.9%), saquinavir (19.6%), and nelfinavir (21.3%). High and medium concentrations were less frequently reported as inaccurate than low concentrations: 13.5%, 13.0%, and 22.4%, respectively. Although the overall performance of the laboratories varied per year, a trend was visible for improvement over time with 19.9% of the results being inaccurate in 2002 (n = 20 laboratories) to 15.7% in 2009 (n = 56 laboratories). The Program provides a proficiency testing program in which laboratories are alerted to potential analytical errors while performing therapeutic drug monitoring in HIV-infected patients. Laboratories should put more effort in adequately analyzing concentrations of antiretroviral drugs with low minimum effective concentrations. PMID:21383652

  19. Japanese Quality Control Circles.

    ERIC Educational Resources Information Center

    Nishiyama, Kazuo

    In recent years, United States scholars with an interest in international business and organizational communication have begun to notice the success of Japanese "quality control circles." These are small groups, usually composed of seven to ten workers, who are organized at the production levels within most large Japanese factories. A typical…

  20. SIMBAD Quality-Control

    NASA Astrophysics Data System (ADS)

    Lesteven, Soizick

    1993-01-01

    Taking into consideration the amount and the complexity of SIMBAD data, it is necessary to use automatic methods to control and assure the quality of the SIMBAD database. One possibility is to apply multivariate data analysis to the content of documents related to astronomical data. The method and first results are presented.

  1. Vgi Quality Control

    NASA Astrophysics Data System (ADS)

    Fonte, C. C.; Bastin, L.; Foody, G.; Kellenberger, T.; Kerle, N.; Mooney, P.; Olteanu-Raimond, A.-M.; See, L.

    2015-08-01

    This paper presents a framework for considering quality control of volunteered geographic information (VGI). Different issues need to be considered during the conception, acquisition and post-acquisition phases of VGI creation. This includes items such as collecting metadata on the volunteer, providing suitable training, giving corrective feedback during the mapping process and use of control data, among others. Two examples of VGI data collection are then considered with respect to this quality control framework, i.e. VGI data collection by National Mapping Agencies and by the most recent Geo-Wiki tool, a game called Cropland Capture. Although good practices are beginning to emerge, there is still the need for the development and sharing of best practice, especially if VGI is to be integrated with authoritative map products or used for calibration and/or validation of land cover in the future.

  2. Aircraft flight test trajectory control

    NASA Technical Reports Server (NTRS)

    Menon, P. K. A.; Walker, R. A.

    1988-01-01

    Two control law design techniques are compared and the performance of the resulting controllers evaluated. The design requirement is for a flight test trajectory controller (FTTC) capable of closed-loop, outer-loop control of an F-15 aircraft performing high-quality research flight test maneuvers. The maneuver modeling, linearization, and design methodologies utilized in this research, are detailed. The results of applying these FTTCs to a nonlinear F-15 simulation are presented.

  3. An NCME Instructional Module on Quality Control Procedures in the Scoring, Equating, and Reporting of Test Scores

    ERIC Educational Resources Information Center

    Allalouf, Avi

    2007-01-01

    There is significant potential for error in long production processes that consist of sequential stages, each of which is heavily dependent on the previous stage, such as the SER (Scoring, Equating, and Reporting) process. Quality control procedures are required in order to monitor this process and to reduce the number of mistakes to a minimum. In…

  4. Dosimetric characteristics and quality control tests for the collimator sectors of the Leksell Gamma Knife Perfexion{sup TM}

    SciTech Connect

    Bhatnagar, Jagdish P.; Novotny, Josef Jr.; Saiful Huq, M.

    2012-01-15

    Purpose: The purpose of this study was to evaluate the dosimetric characteristics of each sector of the Leksell Gamma Knife Perfexion (LGK PFX) and to develop tests that can be done for the routine quality assurance checks of the sectors of the LGK PFX. Methods: The following tests were performed to evaluate the dosimetric characteristics of the sectors: (1) Flash-radiation dose for the 16 mm collimator, (2) transit-radiation dose for the 8 and 4 mm collimators, (3) sector leakage within the radiation cavity and, (4) sector output uniformity. In these tests, the Elekta ABS phantom was used. A micropoint ion-chamber Exradin A16 was placed at the center of the phantom for all measurements. Results: With the version 8.0 of the control software of the MCU in the LGK PFX, the average flash-radiation dose per sector for the 16 mm collimator was measured to be 0.423 {+-} 0.003 cGy, and the average transit-radiation dose per sector for the 8 and 4 mm collimators was measured to be 0.169 {+-} 0.0009 and 0.147 {+-} 0.020 cGy, respectively. The calibration dose rate on the day of measurements was 280.8 cGy/min. Here, the authors have introduced a new concept of ''equivalent-time-duration'' (ETD) to represent the time duration, during which the flash-radiation or the transit-radiation dose is delivered. The ETD is a quotient of the measured dose of the flash-radiation or the transit-radiation and the respective calibrated dose rate for the 16, 8, or 4 mm collimator. The ETD constancy is an indicator of the constancy of the sector movements. The average value of ETD per sector was measured to be 724 {+-} 6, 313 {+-} 2, and 311 {+-} 45 ms for the 16, 8, and 4 mm collimators, respectively. During monthly spot checks, the authors have been measuring the total ETD for the flash-radiation when all eight sectors are open with the 16 mm collimator. The average value of the total ETD of the last 40 consecutive months was measured to be 642 {+-} 10 ms. This number is a useful quality

  5. 30 CFR 74.6 - Quality control.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 30 Mineral Resources 1 2014-07-01 2014-07-01 false Quality control. 74.6 Section 74.6 Mineral... control. The applicant shall describe the way in which each lot of components will be sampled and tested... of the CMDPSU will be maintained in production through adequate quality control procedures, MSHA...

  6. 30 CFR 74.6 - Quality control.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 30 Mineral Resources 1 2012-07-01 2012-07-01 false Quality control. 74.6 Section 74.6 Mineral... control. The applicant shall describe the way in which each lot of components will be sampled and tested... of the CMDPSU will be maintained in production through adequate quality control procedures, MSHA...

  7. Quality of Service Control Based on Virtual Private Network Services in a Wide Area Gigabit Ethernet Optical Test Bed

    NASA Astrophysics Data System (ADS)

    Rea, Luca; Pompei, Sergio; Valenti, Alessandro; Matera, Francesco; Zema, Cristiano; Settembre, Marina

    We report an experimental investigation about the Virtual Private LAN Service technique to guarantee the quality of service in the metro/core network and also in the presence of access bandwidth bottleneck. We also show how the virtual private network can be set up for answering to a user request in a very fast way. The tests were performed in a GMPLS test bed with GbE core routers linked with long (tens of kilometers) GbE G.652 fiber links.

  8. The use of an aircraft test stand for VTOL handling qualities studies. [pilot evaluation of flight controllability

    NASA Technical Reports Server (NTRS)

    Pauli, F. A.; Corliss, L. D.; Selan, S. D.; Gerdes, R. M.; Gossett, T. D.

    1974-01-01

    The VTOL flight tests stand for testing control concepts on the X-14B VSS aircraft in hover, is described. This stand permits realistic and safe piloted evaluation and checkout of various control systems and of parameter variations within each system to determine acceptability to the pilot. Pilots can use it as a practical training tool to practice procedures and flying techniques and become familiar with the aircraft characteristics. Some examples of test experience are given. The test stand allows the X14B to maneuver in hover from centered position + or - 9.7 deg in roll and + or - 9.3 deg in pitch, about + or - 6 deg in yaw, and + or - 15 cm in vertical translation. The unique vertical free flight freedom enables study of liftoffs and landings with power conditions duplicated. The response on the stand agrees well with that measured in free hovering flight, and pilot comments confirm this.

  9. Quality Control of Meteorological Observations

    NASA Technical Reports Server (NTRS)

    Collins, William; Dee, Dick; Rukhovets, Leonid

    1999-01-01

    For the first time, a problem of the meteorological observation quality control (QC) was formulated by L.S. Gandin at the Main Geophysical Observatory in the 70's. Later in 1988 L.S. Gandin began adapting his ideas in complex quality control (CQC) to the operational environment at the National Centers for Environmental Prediction. The CQC was first applied by L.S.Gandin and his colleagues to detection and correction of errors in rawinsonde heights and temperatures using a complex of hydrostatic residuals.Later, a full complex of residuals, vertical and horizontal optimal interpolations and baseline checks were added for the checking and correction of a wide range of meteorological variables. some other of Gandin's ideas were applied and substantially developed at other meteorological centers. A new statistical QC was recently implemented in the Goddard Data Assimilation System. The central component of any quality control is a buddy check which is a test of individual suspect observations against available nearby non-suspect observations. A novel feature of this test is that the error variances which are used for QC decision are re-estimated on-line. As a result, the allowed tolerances for suspect observations can depend on local atmospheric conditions. The system is then better able to accept extreme values observed in deep cyclones, jet streams and so on. The basic statements of this adaptive buddy check are described. Some results of the on-line QC including moisture QC are presented.

  10. Development of a quantitative mass spectrometry multi-attribute method for characterization, quality control testing and disposition of biologics

    PubMed Central

    Rogers, Richard S; Nightlinger, Nancy S; Livingston, Brittney; Campbell, Phil; Bailey, Robert; Balland, Alain

    2015-01-01

    Regulatory agencies have recently recommended a Quality by Design (QbD) approach for the manufacturing of therapeutic molecules. A QbD strategy requires deep understanding at the molecular level of the attributes that are crucial for safety and efficacy and for insuring that the desired quality of the purified protein drug product is met at the end of the manufacturing process. A mass spectrometry (MS)-based approach to simultaneously monitor the extensive array of product quality attributes (PQAs) present on therapeutic molecules has been developed. This multi-attribute method (MAM) uses a combination of high mass accuracy / high resolution MS data generated by Orbitrap technology and automated identification and relative quantification of PQAs with dedicated software (Pinpoint). The MAM has the potential to replace several conventional electrophoretic and chromatographic methods currently used in Quality Control to release therapeutic molecules. The MAM represents an optimized analytical solution to focus on the attributes of the therapeutic molecule essential for function and implement QbD principles across process development, manufacturing and drug disposition. PMID:26186204

  11. Test Control Center exhibit

    NASA Technical Reports Server (NTRS)

    2000-01-01

    Have you ever wondered how the engineers at John C. Stennis Space Center in Hancock County, Miss., test fire a Space Shuttle Main Engine? The Test Control Center exhibit at StenniSphere can answer your questions by simulating the test firing of a Space Shuttle Main Engine. A recreation of one of NASA's test control centers, the exhibit explains and portrays the 'shake, rattle and roar' that happens during a real test firing.

  12. SIMBAD quality-control

    NASA Technical Reports Server (NTRS)

    Lesteven, Soizick

    1992-01-01

    The astronomical database SIMBAD developed at the Centre de donnees astronomiques de Strasbourg presently contains 760,000 objects (stellar and non-stellar). It has the unique characteristic of being structured specifically for astronomical objects. All types of heterogeneous data (bibliographic references, measurements, and sets of identification) are connected with each object. The attributes that define quality of the database include the following. Reliability: cross-identification should not rely upon just exact values object coordinates. It also means that information attached to one simple object should be consistent. The existing data must be controlled in order to start with a reliable base and to cross-identify new data assuring the quality as data grows. Exhaustivity: delays between publication of new informations and their inclusion in the database should be as short as possible. The integrity of the database has to be maintained as data accumulates. Taking the amount of data into consideration and the rate of new data production, it is necessary to use automatic methods. One of the possibilities is to use multivariate data analysis. The factor-space is a n-dimensional relevancy space which is described by the n-axes representing a set of n subject matter headings; the words and phrases can be used to scale the axes and the documents are then a vector average of the terms within them. The application reported herein is based on the NASA-STI bibliographical database. The selected data concern astronomy, astrophysics, and space radiation (102,963 references from 1975 to 1991 included 8070 keywords). The F-space is built from this bibliographical data. By comparing the F-space position obtained from the NASA-STI keywords with the F-space position obtained from the SIMBAD references, the authors will be able to show whether it is possible to retrieve information with a restricted set of words only. If the comparison is valid, this will be a way to enter

  13. Quality in point-of-care testing.

    PubMed

    Nichols, James H

    2003-09-01

    Point-of-care testing (POCT) is an increasingly popular means of providing laboratory testing at or near to the site of patient care. POCT provides rapid results and has the potential to improve patient outcome from earlier treatment. However, a faster result is not necessarily an equivalent result to traditional, core laboratory testing. Preanalytic, analytic and postanalytic factors can influence the quality of POCT and lead to misinterpretation. Concerns over the quality of POCT have resulted in a hierarchy of laboratory regulations in the USA and POCT guidelines are appearing in a number of countries worldwide. Quality POCT must control every aspect of the test and testing process that can affect the ultimate result. Laboratory quality regulations are very similar to industrial quality requirements and POCT can be viewed like any manufacturing business where the product being produced is the test result. Use of industrial management techniques, such as failure mode and effects analysis, can be applied to POCT to isolate and reduce the sources of testing error. Data management is fundamental to quality. Analyzing POCT data can show quality trends before they affect the result. Newer POCT devices have computerized data capture and storage functions that can collect the key information at the time the test is performed and later transmit that data to a POCT data manager or hospital information system. Recent standards, such as the National Committee for Clinical Laboratory Standards POCT1-A, provide a connectivity standard to allow different POCT devices to share a common interface and data manager system, reducing the cost of implementing and maintaining POCT. Guaranteeing POCT quality is resource-intensive and as healthcare budgets get tighter and staffing shortages grow, patient outcome must be weighed against available resources to determine optimum testing strategies. Use of the POCT literature can help establish an evidence-based justification to support

  14. Quality milk and tests for antibiotic residues.

    PubMed

    Sischo, W M

    1996-06-01

    One goal of total quality management is to prevent the occurrence of antibiotics in raw milk shipped from the farm. An effective approach to meet this goal is the implementation of HACCP (Hazard Analysis Critical Control Point) procedures, which are part of the Milk and Dairy Beef Quality Assurance Program for antibiotic avoidance. The program defines 10 critical control points, including screening tests for preventing antibiotic residues. Although milk from individual cows clearly should be tested to ensure that antibiotic-free milk is leaving the farm, it is not clear whether any existing tests can be reliably used on milk samples from individual cows, or even on samples from bulk tanks. The FDA acceptance procedures have not required that bulk milk tests undergo a population evaluation; these tests have not been objectively evaluated for individual cows. Of more concern, detection limits differ among tests, sometimes approaching zero. Despite the intent of the Pasteurized Milk Ordinance, milk acceptability definitions vary between states. In addition, the predictive value of test results has not been integrated into the regulatory process. Although largely ignored by the regulatory agencies, these issues cannot be ignored by the dairy industry. Ultimately, the milk testing program should become a component of the quality process that is centered on the farm and that measures the success of the industry in producing high quality milk rather than being a regulatory program that searches for a flawed product. PMID:8827472

  15. Rupture testing for the quality control of electrodeposited copper interconnections in high-speed, high-density circuits

    NASA Technical Reports Server (NTRS)

    Zakraysek, Louis

    1987-01-01

    Printed Wiring Multilayer Board (PWMLB) structures for high speed, high density circuits are prone to failure due to the microcracking of electrolytic copper interconnections. The failure can occur in the foil that makes up the inner layer traces or in the plated through holes (PTH) deposit that forms the layer to layer interconnections. It is shown that there are some distinctive differences in the quality of Type E copper and that these differences can be detected before its use in a PWMLB. It is suggested that the strength of some Type E copper can be very low when the material is hot and that it is the use of this poor quality material in a PWMLB that results in PTH and inner layer microcracking. Since the PWMLB failure in question are induced by a thermal stress, and since the poorer grades of Type E materials used in these structures are susceptible to premature failure under thermal stress, the use of elevated temperature rupture and creep rupture testing is proposed as a means for screening copper foil, or its PTH equivalent, in order to eliminate the problem of Type E copper microcracking in advanced PWMLBs.

  16. Inclusion of quality controls on leishmaniases molecular tests to increase diagnostic accuracy in research and reference laboratories.

    PubMed

    da C Gonçalves-de-Albuquerque, Suênia; Pessoa-e-Silva, Rômulo; Trajano-Silva, Lays A M; de Morais, Rayana C S; Brandão-Filho, Sinval P; de Paiva-Cavalcanti, Milena

    2015-04-01

    Early detection of leishmaniases and prompt institution of treatment are paramount for individuals and communities affected by these diseases. To overcome the remaining limitations inherent to molecular methods currently used and to ensure the accuracy of results in leishmaniases diagnosis, two triplex polymerase chain reaction (PCR) assays with quality controls for the reactions were developed. Validity indicators were assessed in 186 dog blood samples from endemic areas in Brazil. The level of agreement between the new tools and their singleplex protocols was assessed by kappa analysis. The triplex PCR for visceral leishmaniasis showed sensitivity (S) = 78.68 %, specificity (E) = 85.29 %, and efficiency (e) = 81.05 %. The cutaneous leishmaniasis protocol showed S = 97.29 %, E = 79.16 %, and e = 90.16 %. Both protocols showed good agreement with gold standards. These new tools enable, in a single reaction, the diagnosis of the diseases and the evaluation of the sample quality and DNA extraction process, thus reducing the cost of reagents and avoiding the eventual need for collecting a second sample. PMID:25428552

  17. General aviation fuel quality control

    NASA Technical Reports Server (NTRS)

    Poitz, H.

    1983-01-01

    Quality control measures for aviation gasoline, and some of the differences between quality control on avgas and mogas are discussed. One thing to keep in mind is that with motor gasoline you can always pull off to the side of the road. It's not so easy to do in an airplane. Consequently, there are reasons for having the tight specifications and the tight quality control measures on avgas as compared to motor gasoline.

  18. Implementation and Quality Control of Lung Cancer EGFR Genetic Testing by MALDI-TOF Mass Spectrometry in Taiwan Clinical Practice

    PubMed Central

    Su, Kang-Yi; Kao, Jau-Tsuen; Ho, Bing-Ching; Chen, Hsuan-Yu; Chang, Gee-Cheng; Ho, Chao-Chi; Yu, Sung-Liang

    2016-01-01

    Molecular diagnostics in cancer pharmacogenomics is indispensable for making targeted therapy decisions especially in lung cancer. For routine clinical practice, the flexible testing platform and implemented quality system are important for failure rate and turnaround time (TAT) reduction. We established and validated the multiplex EGFR testing by MALDI-TOF MS according to ISO15189 regulation and CLIA recommendation in Taiwan. Totally 8,147 cases from Aug-2011 to Jul-2015 were assayed and statistical characteristics were reported. The intra-run precision of EGFR mutation frequency was CV 2.15% (L858R) and 2.77% (T790M); the inter-run precision was CV 3.50% (L858R) and 2.84% (T790M). Accuracy tests by consensus reference biomaterials showed 100% consistence with datasheet (public database). Both analytical sensitivity and specificity were 100% while taking Sanger sequencing as the gold-standard method for comparison. EGFR mutation frequency of peripheral blood mononuclear cell for reference range determination was 0.002 ± 0.016% (95% CI: 0.000–0.036) (L858R) and 0.292 ± 0.289% (95% CI: 0.000–0.871) (T790M). The average TAT was 4.5 working days and the failure rate was less than 0.1%. In conclusion, this study provides a comprehensive report of lung cancer EGFR mutation detection from platform establishment, method validation to clinical routine practice. It may be a reference model for molecular diagnostics in cancer pharmacogenomics. PMID:27480787

  19. First evaluation after implementation of a quality control system for the second line drug susceptibility testing of Mycobacterium tuberculosis joint efforts in low and high incidence countries.

    PubMed

    Hillemann, Doris; Hoffner, Sven; Cirillo, Daniela; Drobniewski, Francis; Richter, Elvira; Rüsch-Gerdes, Sabine

    2013-01-01

    Three networks/projects involving 27 European countries were established to investigate the quality of second-line drug (SLD) susceptibility testing with conventional and molecular methods. 1. The "Baltic-Nordic TB-Laboratory Network" comprised 11 reference laboratories in the Baltic-Nordic States. They performed SLD testing in the first phase with a panel of 20 Mycobacterium tuberculosis strains. After several laboratories made technical changes a second panel of 10 strains with a higher proportion of resistant strains were tested. Although the concordance for Ofloxacin, Kanamycin, and Capreomycin was consistently high, the largest improvements in performance were achieved for the analysis of Ofloxacin resistant (from 88.9 to 95.0%), and Capreomycin resistant (from 71.0 to 88.9%) strains. 2. Within the FP7 TB PAN-NET project (EU Grant agreement 223681) a quality control panel to standardize the EQA (External Quality Assurance) for first-line drugs (FLD) and SLD testing for phenotypic and molecular methods was established. The strains were characterized by their robustness, unambiguous results when tested, and low proportion of secondary drug resistances. 3. The (European Reference Laboratory Network-TB) ERLN-TB network analyzed four different panels for drug resistance testing using phenotypic and molecular methods; in two rounds in 2010 the 31 participating laboratories began with 5 strains, followed by 10 strains and 6 additional crude DNA extracts in 2011 and 2012 were examined by conventional DST and molecular methods. Overall, we demonstrated the importance of developing inter-laboratory networks to establish quality assurance and improvement of SLD testing of M. tuberculosis. PMID:24146924

  20. First Evaluation after Implementation of a Quality Control System for the Second Line Drug Susceptibility Testing of Mycobacterium tuberculosis Joint Efforts in Low and High Incidence Countries

    PubMed Central

    Hillemann, Doris; Hoffner, Sven; Cirillo, Daniela; Drobniewski, Francis; Richter, Elvira; Rüsch-Gerdes, Sabine

    2013-01-01

    Three networks/projects involving 27 European countries were established to investigate the quality of second-line drug (SLD) susceptibility testing with conventional and molecular methods. 1. The “Baltic-Nordic TB-Laboratory Network” comprised 11 reference laboratories in the Baltic-Nordic States. They performed SLD testing in the first phase with a panel of 20 Mycobacterium tuberculosis strains. After several laboratories made technical changes a second panel of 10 strains with a higher proportion of resistant strains were tested. Although the concordance for Ofloxacin, Kanamycin, and Capreomycin was consistently high, the largest improvements in performance were achieved for the analysis of Ofloxacin resistant (from 88.9 to 95.0%), and Capreomycin resistant (from 71.0 to 88.9%) strains. 2. Within the FP7 TB PAN-NET project (EU Grant agreement 223681) a quality control panel to standardize the EQA (External Quality Assurance) for first-line drugs (FLD) and SLD testing for phenotypic and molecular methods was established. The strains were characterized by their robustness, unambiguous results when tested, and low proportion of secondary drug resistances. 3. The (European Reference Laboratory Network-TB) ERLN-TB network analyzed four different panels for drug resistance testing using phenotypic and molecular methods; in two rounds in 2010 the 31 participating laboratories began with 5 strains, followed by 10 strains and 6 additional crude DNA extracts in 2011 and 2012 were examined by conventional DST and molecular methods. Overall, we demonstrated the importance of developing inter-laboratory networks to establish quality assurance and improvement of SLD testing of M. tuberculosis. PMID:24146924

  1. Quality control on the frontier

    PubMed Central

    Paszkiewicz, Konrad H.; Farbos, Audrey; O'Neill, Paul; Moore, Karen

    2014-01-01

    In the world of high-throughput sequencing there are numerous challenges to effective data quality control. There are no single quality metrics which are appropriate in all conditions. Here we detail the different open source software used at the Exeter Sequencing Service to provide generic quality control information, as well as more specific metrics for genomic and transcriptomic libraries run on Illumina platforms. PMID:24904650

  2. [Quality control of printed patient information].

    PubMed

    Herm, Kerstin; Linden, Michael

    2013-05-01

    Printed material is an important part in patient information and is called bibliotherapy. It is subject to quality control similar to any other types of treatment. This paper presents an outline of important quality criteria and methods of quality control. Important quality criteria are: (a) Correctness and validity of content evaluated by mentioning the expertise of the authors, appraisal through external experts, reference to scientific literature, and empirical tests of the content, (b) Readability in respect to text structure measured by the "Flesch-Reading-Ease-Formula" supported by fair graphical design including fond and structure of text, (c) Comprehensibility tested by feedback of patients or standardized by the Hamburg comprehensibility rating, (d) Utility including securing availability, acceptance, differential indication and use. Writing and publication of patient leaflets must be accompanied by quality control measures. PMID:23446824

  3. Quality assurance/quality control manual; National Water Quality Laboratory

    USGS Publications Warehouse

    Pritt, J.W.; Raese, J.W.

    1995-01-01

    Quality-control practices are established for the operation of the U.S. Geological Survey's National Water Quality Laboratory. These practices specify how samples are preserved, shipped, and analyzed in the Laboratory. This manual documents the practices that are currently (1995) used in the Laboratory.

  4. Environmental quality control report. [Semiannual] report, July--December 1988

    SciTech Connect

    Bishop, C.T.

    1989-04-14

    This report presents the details of the Mound Laboratory EPA-NPDES Quality Assurance Program, the DOE Quality Assessment Program Results, Proficiency Environmental Testing Program and Plutonium in Urine Quality Control for 1988.

  5. Quality control tests of lab-reared Cydia pomonella and Cactoblastis cactorum field performance: Comparison of laboratory and field bioassays.

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Research, operational, and commercial programs which rely on mass-reared insects of high quality and performance, need accurate methods for monitoring quality degradation during each step of production, handling and release. With continued interest in the use of the sterile insect technique (SIT) a...

  6. The effectiveness of computer reminders for improving quality assessment for point-of-care testing in general practice—a randomized controlled trial

    PubMed Central

    2013-01-01

    Background Computer reminders are increasingly being applied in efforts to improve quality and patient safety. However, research is still needed to establish the effectiveness of different kinds of reminders in various settings. This study aimed to evaluate the effectiveness of computer reminders for improving adherence to a quality assessment scheme for point-of-care testing in general practice. Method The study was conducted as a randomized controlled crossover trial among general practices in the Capital Region of Denmark. The intervention consisted of sending computer reminders (ComRem) to practices not adhering to the guideline recommendations of split testing for hemoglobin and glucose. Practices were randomly allocated into two groups. During the first follow-up period, one of the groups received the ComRem intervention together with the general implementation activities (GIA), while the other group only received the GIA. For the second follow-up period, the intervention was switched between the two groups. Outcomes were measured as split test procedure adherence. Results A total of 142 practices were randomly allocated to the early intervention group and 144 practices to the late intervention group (the control group in the first follow-up period). In the first intervention period, the mean number of split tests performed in the group receiving ComRem group increased from 1.22 to 3.76 (out of eight possible tests) while the mean number of split tests increased from 1.11 to 2.35 in the group targeted by GIA only (p = 0.0059). After the crossover, a similar effect of reminders was observed. Furthermore, the developments in outcome measures over time showed a strong effect of computer reminders beyond the intervention periods. Conclusion There was a significant effect of computer reminders on adherence to the quality assessment scheme for point-of-care testing. Thus, computer reminders seem to be useful for supporting the implementation of relatively simple

  7. Quality Control by Artificial Vision

    SciTech Connect

    Lam, Edmond Y.; Gleason, Shaun Scott; Niel, Kurt S.

    2010-01-01

    Computational technology has fundamentally changed many aspects of our lives. One clear evidence is the development of artificial-vision systems, which have effectively automated many manual tasks ranging from quality inspection to quantitative assessment. In many cases, these machine-vision systems are even preferred over manual ones due to their repeatability and high precision. Such advantages come from significant research efforts in advancing sensor technology, illumination, computational hardware, and image-processing algorithms. Similar to the Special Section on Quality Control by Artificial Vision published two years ago in Volume 17, Issue 3 of the Journal of Electronic Imaging, the present one invited papers relevant to fundamental technology improvements to foster quality control by artificial vision, and fine-tuned the technology for specific applications. We aim to balance both theoretical and applied work pertinent to this special section theme. Consequently, we have seven high-quality papers resulting from the stringent peer-reviewing process in place at the Journal of Electronic Imaging. Some of the papers contain extended treatment of the authors work presented at the SPIE Image Processing: Machine Vision Applications conference and the International Conference on Quality Control by Artificial Vision. On the broad application side, Liu et al. propose an unsupervised texture image segmentation scheme. Using a multilayer data condensation spectral clustering algorithm together with wavelet transform, they demonstrate the effectiveness of their approach on both texture and synthetic aperture radar images. A problem related to image segmentation is image extraction. For this, O'Leary et al. investigate the theory of polynomial moments and show how these moments can be compared to classical filters. They also show how to use the discrete polynomial-basis functions for the extraction of 3-D embossed digits, demonstrating superiority over Fourier

  8. 40 CFR 136.7 - Quality assurance and quality control.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... PROGRAMS (CONTINUED) GUIDELINES ESTABLISHING TEST PROCEDURES FOR THE ANALYSIS OF POLLUTANTS § 136.7 Quality... referred to as a spiked blank, or laboratory control sample (LCS); (v) Matrix spike (MS) and matrix spike duplicate (MSD), or laboratory fortified matrix (LFM) and LFM duplicate, may be used for suspected...

  9. Development of methodology and technology for identifying and quantifying emission products from open-burning and open-detonation thermal-treatment methods. Bangbox Test Series. Volume 3. Quality assurance and quality control. Final report, Dec 88-Jan 92

    SciTech Connect

    Johnson, M.

    1992-01-01

    The 1989 BangBox test validated technologies and methodologies proposed for identifying and quantifying emissions resulting from the open burning (OB) of propellants and open detonation (OD) of explosives. This test also provided the first credible data on combustion products resulting from OB/OD treatment procedures. The vigorous quality assurance/quality control (QA/QC) program established well before the first trial was continued through the reporting phase. Major elements of the OA/QC program were a quality assurance program plan (QAPP), letters of instruction (LOI) covering all technical aspects of the testing program, a sample identification and tracking system, test monitoring by the scientific support contractor, visits to the test site and assay laboratories by an independent QA contractor, assays by different laboratories using different Instruments (gas chromatograph/mass spectrometer and supercritical fluid chromatograph/mass spectrometer), equipment audits by the U.S. Environmental Protection Agency's Atmospheric Research and Exposure Assessment Laboratory (AREAL), assay of samples spiked by the AREAL, and cooperative assistance from the U.S. Army Toxic and Hazardous Material Agency, and the U.S. Army Environmental Hygiene Agency. open burning; open detonation; OB/OD; TNT; double base propellant; manufacturers residue propellant; air emissions; thermal treatment; carbon balance; emission factor.

  10. 10 CFR 26.167 - Quality assurance and quality control.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false Quality assurance and quality control. 26.167 Section 26... Department of Health and Human Services § 26.167 Quality assurance and quality control. (a) Quality assurance program. Each HHS-certified laboratory shall have a quality assurance program that encompasses all...

  11. Heat treatment and the use of additives to improve the stability of paralytic shellfish poisoning toxins in shellfish tissue reference materials for internal quality control and proficiency testing.

    PubMed

    Burrell, Stephen; Clion, Valentin; Auroy, Virginie; Foley, Barry; Turner, Andrew D

    2015-06-01

    The need for homogenous reference materials stable for paralytic shellfish toxins is vital for the monitoring and quality assurance of these potent neurotoxins in shellfish. Two stabilisation techniques were investigated, heat treatment through autoclaving and the addition of preserving additives into the tissue matrix. Short and long-term stability experiments as well as homogeneity determination were conducted on materials prepared by both techniques in comparison with an untreated control using two LC-FLD methods. Both techniques improved the stability of the matrix and the PSP toxins present compared to the controls. A material was prepared using the combined techniques of heat treatment followed by spiking with additives and data is presented from this optimised reference material as used over a two year period in the Irish national monitoring program and in a development exercise as part of a proficiency testing scheme operated by QUASIMEME (Quality Assurance of Information for Marine Environmental Monitoring in Europe) since 2011. The results were indicative of the long-term stability of the material as evidenced through consistent assigned values in the case of the proficiency testing scheme and a low relative standard deviation of 10.5% for total toxicity data generated over 24 months. PMID:25816999

  12. Principles and Practices for Quality Assurance and Quality Control

    USGS Publications Warehouse

    Jones, Berwyn E.

    1999-01-01

    Quality assurance and quality control are vital parts of highway runoff water-quality monitoring projects. To be effective, project quality assurance must address all aspects of the project, including project management responsibilities and resources, data quality objectives, sampling and analysis plans, data-collection protocols, data quality-control plans, data-assessment procedures and requirements, and project outputs. Quality control ensures that the data quality objectives are achieved as planned. The historical development and current state of the art of quality assurance and quality control concepts described in this report can be applied to evaluation of data from prior projects.

  13. Optimal inoculation methods and quality control for the NCCLS oxacillin agar screen test for detection of oxacillin resistance in Staphylococcus aureus.

    PubMed

    Swenson, J M; Spargo, J; Tenover, F C; Ferraro, M J

    2001-10-01

    To define more precisely the inoculation methods to be used in the oxacillin screen test for Staphylococcus aureus, we tested agar screen plates prepared in house with 6 microg of oxacillin/ml and 4% NaCl using the four different inoculation methods that would most likely be used by clinical laboratories. The organisms selected for testing were 19 heteroresistant mecA-producing strains and 41 non-mecA-producing strains for which oxacillin MICs were near the susceptible breakpoint. The inoculation method that was preferred by all four readers and that resulted in the best combination of sensitivity and specificity was a 1-microl loopful of a 0.5 McFarland suspension. A second objective of the study was to then use this method to inoculate plates from five different manufacturers of commercially prepared media. Although all commercial media performed with acceptable sensitivity compared to the reference lot, one of the commercial lots demonstrated a lack of specificity. Those lots of oxacillin screen medium that fail to grow heteroresistant strains can be detected by using S. aureus ATCC 43300 as a positive control in the test and by using transmitted light to carefully examine the plates for any growth. However, lack of specificity with commercial lots may be difficult to detect using any of the current quality control organisms. PMID:11574618

  14. HPLC for quality control of polyimides

    NASA Technical Reports Server (NTRS)

    Young, P. R.; Sykes, G. F.

    1979-01-01

    High Pressure Liquid Chromatography (HPLC) as a quality control tool for polyimide resins and prepregs are presented. A data base to help establish accept/reject criteria for these materials was developed. This work is intended to supplement, not replace, standard quality control tests normally conducted on incoming resins and prepregs. To help achieve these objectives, the HPLC separation of LARC-160 polyimide precursor resin was characterized. Room temperature resin aging effects were studied. Graphite reinforced composites made from fresh and aged resin were fabricated and tested to determine if changes observed by HPLC were significant.

  15. Laboratory quality control based on risk management.

    PubMed

    Nichols, James H

    2011-01-01

    Risk management is the systematic application of management policies, procedures, and practices to the tasks of analyzing, evaluating, controlling and monitoring risk (the effect of uncertainty on objectives). Clinical laboratories conduct a number of activities that could be considered risk management including verification of performance of new tests, troubleshooting instrument problems and responding to physician complaints. Development of a quality control plan for a laboratory test requires a process map of the testing process with consideration for weak steps in the preanalytic, analytic and postanalytic phases of testing where there is an increased probability of errors. Control processes that either prevent or improve the detection of errors can be implemented at these weak points in the testing process to enhance the overall quality of the test result. This manuscript is based on a presentation at the 2nd International Symposium on Point of Care Testing held at King Faisal Specialist Hospital in Riyadh, Saudi Arabia on October 12-13, 2010. Risk management principles will be reviewed and progress towards adopting a new Clinical and Laboratory Standards Institute Guideline for developing laboratory quality control plans based on risk management will be discussed. PMID:21623049

  16. Analytical laboratory quality control charting

    SciTech Connect

    O'Bryan, Ervin F.

    2001-06-11

    In life the importance of setting goals is stressed. The desired end result must be envisioned to chart a path and determine indicators to provide feedback on the process. Quality does not happen by accident but is achieved through a constant process of setting goals, process development, monitoring process indicators, fine tuning the process, and achieving results. These goals are to be focused and clearly measurable. In industry and life the setting of goals with clear process indicators is often difficult because of the variable end result and scarcity of measurements. Laboratories are fortunate in that they have a plethora of measurements with known or desired end results (controls) to monitor the process and give instantaneous feedback on quality. A key quality tool used by the laboratory to monitor and evaluate the lab processes is control charting. When properly utilized Quality Control (QC) Charts allow labs to be proactive in addressing problems rather than reactive. Several methods are available for control charting and some are listed in the references/information sources. The content for this paper is based on the control-charting program utilized at the Department of Energy's Fernald site. This control-charting program has specific areas of emphasis, simple charts, trend analyses, and effective follow-up.

  17. 40 CFR 85.2233 - Steady state test equipment calibrations, adjustments, and quality control-EPA 91.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... inspections per year) and may be performed in conjunction with the gas calibration described in paragraph (e... out from testing, and requires repair of leaks. (e) Gas calibration. (1) On each operating day in high... requirements of paragraph (e)(3) of this section into the analyzer through the calibration port. No...

  18. 40 CFR 85.2233 - Steady state test equipment calibrations, adjustments, and quality control-EPA 91.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... for HC, CO, and CO2 and must continually compensate for changes in barometric pressure. Calibration...-point calibration within 72 hours before each test, unless changes in barometric pressure are... tolerance range. The pressure in the sample cell must be the same with the calibration gas flowing...

  19. 40 CFR 85.2233 - Steady state test equipment calibrations, adjustments, and quality control-EPA 91.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... for HC, CO, and CO2 and must continually compensate for changes in barometric pressure. Calibration...-point calibration within 72 hours before each test, unless changes in barometric pressure are... tolerance range. The pressure in the sample cell must be the same with the calibration gas flowing...

  20. 40 CFR 85.2233 - Steady state test equipment calibrations, adjustments, and quality control-EPA 91.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... for HC, CO, and CO2 and must continually compensate for changes in barometric pressure. Calibration...-point calibration within 72 hours before each test, unless changes in barometric pressure are... tolerance range. The pressure in the sample cell must be the same with the calibration gas flowing...

  1. Quality control programme in mammography: second level quality controls.

    PubMed

    Nassivera, E; Nardin, L

    1997-06-01

    Mammography is the most reliable method by which to detect lesions in the breast. Since contrast between normal and pathological areas in the breast is extremely low, mammographic image quality should reach high standards without exceeding acceptable exposure levels for the breast. A quality control programme in mammography has been implemented. This programme is subdivided into two levels. The first consists of simple daily checks of image quality and film processing, while the second deals with more complex checks of mammographic unit, screen-film system, darkroom, illuminators, viewing conditions and reference dose determination. The values of all the parameters undergoing measurement are compared with the limiting values given by National and International Protocols. This paper describes the second level controls carried out every 6 months by the medical physicist. The parameters described are only those which have been studied and analysed in detail since the quality control programme in mammography was implemented. Such parameters (kilovoltage, focal spot dimension, half value layer, tube output, automatic exposure control system, screen-film characteristic curve and mean glandular dose) were measured during the period 1991-1995 and the results summarised. The values obtained prove the constant correct functioning of the equipment. PMID:9227255

  2. 10 CFR 26.167 - Quality assurance and quality control.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 1 2011-01-01 2011-01-01 false Quality assurance and quality control. 26.167 Section 26.167 Energy NUCLEAR REGULATORY COMMISSION FITNESS FOR DUTY PROGRAMS Laboratories Certified by the Department of Health and Human Services § 26.167 Quality assurance and quality control. (a) Quality assurance program. Each HHS-certified laboratory...

  3. 10 CFR 26.167 - Quality assurance and quality control.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 1 2014-01-01 2014-01-01 false Quality assurance and quality control. 26.167 Section 26.167 Energy NUCLEAR REGULATORY COMMISSION FITNESS FOR DUTY PROGRAMS Laboratories Certified by the Department of Health and Human Services § 26.167 Quality assurance and quality control. (a) Quality assurance program. Each HHS-certified laboratory...

  4. 10 CFR 26.167 - Quality assurance and quality control.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 1 2012-01-01 2012-01-01 false Quality assurance and quality control. 26.167 Section 26.167 Energy NUCLEAR REGULATORY COMMISSION FITNESS FOR DUTY PROGRAMS Laboratories Certified by the Department of Health and Human Services § 26.167 Quality assurance and quality control. (a) Quality assurance program. Each HHS-certified laboratory...

  5. An approach combining real-time release testing with near-infrared spectroscopy to improve quality control efficiency of Rhizoma paridis

    NASA Astrophysics Data System (ADS)

    Li, Yerui; Liu, Bowen; Geng, Shu; Kim, Sungchan; Jin, Ye; Liu, Xuesong; Luan, Lianjun; Wu, Yongjiang; Chen, Yong

    2016-03-01

    Raw material examination is a critical process in the industrial production of traditional Chinese medicine (TCM); high accuracy and minimal time consumption are both required. In this study, near-infrared (NIR) spectroscopy was applied to improve the quality control efficiency of Rhizoma paridis. Partial least squares regression (PLSR) was first used to develop quantitative calibration models, and the discriminant analysis model was established to qualitatively discriminate the qualified samples from the unqualified samples. These two established NIR models were applied for real-time release testing (RTRT) of R. paridis. R. paridis saponins (RPS) ≥ 0.6% and moisture ≤ 12% were used as the quantitative releasing criteria of RTRT according to the Chinese Pharmacopoeia. Qualified samples classified by the discriminant analysis model were deemed to meet the qualitative releasing criterion of RTRT. Using the established quantitative model, 24 samples were allowed to be released to the subsequent production processes with 100% accuracy. For the qualitative RTRT analysis, three samples were misclassified as the unqualified class and were released unsuccessfully, the accuracy of the qualitative RTRT was 90%. Therefore, the quantitative RTRT was more feasible for actual manufacturing processes. Based on this study, a rapid and effective quantitative NIR spectroscopic method was proposed for the RTRT of R. paridis. The combination of RTRT and NIR spectroscopy could be a potential tool to improve the quality control efficiency of R. paridis.

  6. Quality Control & Design in Science Learning

    ERIC Educational Resources Information Center

    Sumrall, William J.; Schillinger, Don

    2003-01-01

    One area of science education that is, at times, neglected involves lessons on technological concepts of these principles--designing, testing, and quality control. Instead, a focus upon science concepts from a pure, and unapplied, perspective is the norm. Thus, while students may learn the equation "mass divided by volume equals density," the…

  7. Pursuing the Qualities of a "Good" Test

    ERIC Educational Resources Information Center

    Coniam, David

    2014-01-01

    This article examines the issue of the quality of teacher-produced tests, limiting itself in the current context to objective, multiple-choice tests. The article investigates a short, two-part 20-item English language test. After a brief overview of the key test qualities of reliability and validity, the article examines the two subtests in terms…

  8. 10 CFR 71.123 - Test control.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 2 2013-01-01 2013-01-01 false Test control. 71.123 Section 71.123 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) PACKAGING AND TRANSPORTATION OF RADIOACTIVE MATERIAL Quality Assurance § 71.123 Test control. The licensee, certificate holder, and applicant for a CoC shall establish a...

  9. 10 CFR 71.123 - Test control.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 2 2014-01-01 2014-01-01 false Test control. 71.123 Section 71.123 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) PACKAGING AND TRANSPORTATION OF RADIOACTIVE MATERIAL Quality Assurance § 71.123 Test control. The licensee, certificate holder, and applicant for a CoC shall establish a...

  10. 10 CFR 71.123 - Test control.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false Test control. 71.123 Section 71.123 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) PACKAGING AND TRANSPORTATION OF RADIOACTIVE MATERIAL Quality Assurance § 71.123 Test control. The licensee, certificate holder, and applicant for a CoC shall establish a...

  11. How intense quality control improves hydraulic fracturing

    SciTech Connect

    Ely, J.W.

    1996-11-01

    Not unlike the subject of Forced Closure, Intense Quality Control is probably misnamed. What actually is discussed in this article is pilot testing of the fracturing fluids actually pumped at in-situ conditions of temperature and shear. Presented here is development of the need for onsite testing, equipment used, shear and viscosity curves from several jobs showing what went wrong that would otherwise not have been known, and a discussion of borate gel fluids.

  12. Rotorcraft flying qualities improvement using advanced control

    NASA Technical Reports Server (NTRS)

    Walker, D.; Postlethwaite, I.; Howitt, J.; Foster, N.

    1993-01-01

    We report on recent experience gained when a multivariable helicopter flight control law was tested on the Large Motion Simulator (LMS) at DRA Bedford. This was part of a study into the application of multivariable control theory to the design of full-authority flight control systems for high-performance helicopters. In this paper, we present some of the results that were obtained during the piloted simulation trial and from subsequent off-line simulation and analysis. The performance provided by the control law led to level 1 handling quality ratings for almost all of the mission task elements assessed, both during the real-time and off-line analysis.

  13. Quality control of EUVE databases

    NASA Technical Reports Server (NTRS)

    John, L. M.; Drake, J.

    1992-01-01

    The publicly accessible databases for the Extreme Ultraviolet Explorer include: the EUVE Archive mailserver; the CEA ftp site; the EUVE Guest Observer Mailserver; and the Astronomical Data System node. The EUVE Performance Assurance team is responsible for verifying that these public EUVE databases are working properly, and that the public availability of EUVE data contained therein does not infringe any data rights which may have been assigned. In this poster, we describe the Quality Assurance (QA) procedures we have developed from the approach of QA as a service organization, thus reflecting the overall EUVE philosophy of Quality Assurance integrated into normal operating procedures, rather than imposed as an external, post facto, control mechanism.

  14. A step forward in the quality control testing of inactivated rabies vaccines - extensive evaluation of European vaccines by using alternative methods to the in vivo potency tests.

    PubMed

    Servat, Alexandre; Kempff, Sébastien; Brogat, Valère; Litaize, Estelle; Schereffer, Jean-Luc; Cliquet, Florence

    2015-03-01

    The mouse challenge test still remains the reference method for the potency determination of human and animal inactivated rabies vaccines, and it is still widely used throughout the world. This test suffers from many disadvantages - it is expensive and time consuming, uses a large number of mice, causes significant animal distress, and suffers from high variability. Recently, the European Pharmacopoeia has recognised the use of a serological potency assay (SPA) as an alternative method to the challenge test. This new test is based on the determination of rabies neutralising antibody titres in vaccinated mice, by using the modified Rapid Fluorescent Focus Inhibition Test (mRFFIT). With the objective of adopting this new method for the batch release of inactivated rabies vaccines, we evaluated its performance on a large collection of rabies vaccines currently assessed in our laboratory. The Fluorescent Antibody Virus Neutralisation test (FAVNt) was used in parallel with the mRFFIT, and the results were compared to the mouse challenge test. Our results demonstrate that the SPA is capable of estimating the potency of vaccines formulated with a potency margin well above the minimum of 1IU/dose. For low potency vaccines, this new method demonstrated some limitations, due to the recurrent invalidation of the assay. We have also demonstrated the superior sensitivity of the FAVNt when compared to the mRFFIT, and the importance of minimising the risk of detecting non-responders in vaccinated mice. PMID:25802995

  15. NIF ICCS Test Controller for Automated & Manual Testing

    SciTech Connect

    Zielinski, J S

    2007-10-03

    The National Ignition Facility (NIF) Integrated Computer Control System (ICCS) is a large (1.5 MSLOC), hierarchical, distributed system that controls all aspects of the NIF laser [1]. The ICCS team delivers software updates to the NIF facility throughout the year to support shot operations and commissioning activities. In 2006, there were 48 releases of ICCS: 29 full releases, 19 patches. To ensure the quality of each delivery, thousands of manual and automated tests are performed using the ICCS Test Controller test infrastructure. The TestController system provides test inventory management, test planning, automated test execution and manual test logging, release testing summaries and test results search, all through a web browser interface. Automated tests include command line based frameworks server tests and Graphical User Interface (GUI) based Java tests. Manual tests are presented as a checklist-style web form to be completed by the tester. The results of all tests, automated and manual, are kept in a common repository that provides data to dynamic status reports. As part of the 3-stage ICCS release testing strategy, the TestController system helps plan, evaluate and track the readiness of each release to the NIF facility.

  16. [Internal Quality Control and External Quality Assessment on POCT].

    PubMed

    Kuwa, Katsuhiko

    2015-02-01

    The quality management (QM) of POCT summarizes its internal quality control (IQC) and external quality assessment (EQA). For QM requirements in POCT, ISO 22870-Point-of-care testing (POCT) -Requirements for quality and competence and ISO 15189-Medical laboratories-Requirements for quality and competence, it is performed under the guidance of the QM committee. The role of the POC coordinator and/or medical technologist of the clinical laboratory is important. On measurement performance of POCT devices, it is necessary to confirm data on measurement performance from the manufacturer other than those in the inserted document. In the IQC program, the checking and control of measurement performance are the targets. On measurements of QC samples by the manufacturer, it is essential to check the function of devices. In addition, regarding the EQA program, in 2 neighboring facilities, there is an effect to confirm the current status of measurement and commutability assessment in these laboratories using whole blood along with residual blood samples from daily examinations in the clinical laboratory. PMID:26529974

  17. Quality control and beam test of GEM detectors for future upgrades of the CMS muon high rate region at the LHC

    NASA Astrophysics Data System (ADS)

    Abbaneo, D.; Abbas, M.; Abbrescia, M.; Abdelalim, A. A.; Abi Akl, M.; Ahmed, W.; Ahmed, W.; Altieri, P.; Aly, R.; Armaingaud, C.; Asawatangtrakuldee, C.; Ashfaq, A.; Aspell, P.; Assran, Y.; Awan, I.; Bally, S.; Ban, Y.; Banerjee, S.; Barria, P.; Benussi, L.; Bhopatkar, V.; Bianco, S.; Bos, J.; Bouhali, O.; Braibant, S.; Buontempo, S.; Cai, J.; Calabria, C.; Caponero, M.; Caputo, C.; Cassese, F.; Castaneda, A.; Cauwenbergh, S.; Cavallo, F. R.; Celik, A.; Choi, M.; Choi, K.; Choi, S.; Christiansen, J.; Cimmino, A.; Colafranceschi, S.; Colaleo, A.; Conde Garcia, A.; Dabrowski, M. M.; De Lentdecker, G.; De Oliveira, R.; De Robertis, G.; Dildick, S.; Dildick, S.; Dorney, B.; Elmetenawee, W.; Fabrice, G.; Ferrini, M.; Ferry, S.; Flanagan, W.; Giacomelli, P.; Gilmore, J.; Guiducci, L.; Gutierrez, A.; Hadjiiska, R. M.; Hassan, A.; Hauser, J.; Hoepfner, K.; Hohlmann, M.; Hoorani, H.; Jeng, Y. G.; Kamon, T.; Karchin, P. E.; Kim, H. S.; Khotilovich, V.; Krutelyov, S.; Kumar, A.; Lee, J.; Lenzi, T.; Litov, L.; Loddo, F.; Maerschalk, T.; Magazzu, G.; Maggi, M.; Maghrbi, Y.; Magnani, A.; Majumdar, N.; Mal, P. K.; Mandal, K.; Marchioro, A.; Marinov, A.; Merlin, J. A.; Mohammed, N.; Mohanty, A. K.; Mohapatra, A.; Muhammad, S.; Mukhopadhyay, S.; Naimuddin, M.; Nuzzo, S.; Oliveri, E.; Pant, L. M.; Paolucci, P.; Park, I.; Passeggio, G.; Pavlov, B.; Philipps, B.; Phipps, M.; Piccolo, D.; Postema, H.; Pugliese, G.; Baranac, A. Puig; Radi, A.; Radogna, R.; Raffone, G.; Ramkrishna, S.; Ranieri, A.; Riccardi, C.; Rodrigues, A.; Ropelewski, L.; RoyChowdhury, S.; Ryu, M. S.; Ryu, G.; Safonov, A.; Sakharov, A.; Salva, S.; Saviano, G.; Sharma, A.; Swain, S. K.; Talvitie, J. P.; Talvitie, J. P.; Tamma, C.; Tatarinov, A.; Teng, H.; Turini, N.; Tuuva, T.; Twigger, J.; Tytgat, M.; Vai, I.; Van Stenis, M.; Venditi, R.; Verhagen, E.; Verwilligen, P.; Vitulo, P.; Wang, D.; Wang, M.; Yang, U.; Yang, Y.; Yonamine, R.; Zaganidis, N.; Zenoni, F.; Zhang, A.

    2015-03-01

    Gas Electron Multipliers (GEM) are a proven position sensitive gas detector technology which nowadays is becoming more widely used in High Energy Physics. GEMs offer an excellent spatial resolution and a high particle rate capability, with a close to 100% detection efficiency. In view of the high luminosity phase of the CERN Large Hadron Collider, these aforementioned features make GEMs suitable candidates for the future upgrades of the Compact Muon Solenoid (CMS) detector. In particular, the CMS GEM Collaboration proposes to cover the high-eta region of the muon system with large-area triple-GEM detectors, which have the ability to provide robust and redundant tracking and triggering functions. In this contribution, after a general introduction and overview of the project, the construction of full-size trapezoidal triple-GEM prototypes will be described in more detail. The procedures for the quality control of the GEM foils, including gain uniformity measurements with an x-ray source will be presented. In the past few years, several CMS triple-GEM prototype detectors were operated with test beams at the CERN SPS. The results of these test beam campaigns will be summarised.

  18. Quality control by a mobile molecular workshop: Quality versus quantity

    NASA Astrophysics Data System (ADS)

    Sharma, Ajeet K.; Chowdhury, Debashish

    2010-09-01

    Ribosome is a molecular machine that moves on a messenger RNA (mRNA) track while, simultaneously, polymerizing a protein using the mRNA also as the corresponding template. We define, and analytically calculate, two different measures of the efficiency of this machine. However, we argue that its performance is evaluated better in terms of the translational fidelity and the speed with which it polymerizes a protein. We define both these quantities and calculate these analytically. Fidelity is a measure of the quality of the products, while the total quantity of products synthesized in a given interval depends on the speed of polymerization. We show that for synthesizing a large quantity of proteins, it is not necessary to sacrifice the quality. We also explore the effects of the quality control mechanism on the strength of mechanochemical coupling. We suggest experiments for testing some of the ideas presented here.

  19. 23 CFR 1340.8 - Quality control.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... OBSERVATIONAL SURVEYS OF SEAT BELT USE Survey Design Requirements § 1340.8 Quality control. (a) Quality control... control monitors involved in seat belt use surveys shall have received training in data...

  20. 23 CFR 1340.8 - Quality control.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... OBSERVATIONAL SURVEYS OF SEAT BELT USE Survey Design Requirements § 1340.8 Quality control. (a) Quality control... control monitors involved in seat belt use surveys shall have received training in data...

  1. 23 CFR 1340.8 - Quality control.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... OBSERVATIONAL SURVEYS OF SEAT BELT USE Survey Design Requirements § 1340.8 Quality control. (a) Quality control... control monitors involved in seat belt use surveys shall have received training in data...

  2. 7 CFR 930.44 - Quality control.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Quality control. 930.44 Section 930.44 Agriculture... MICHIGAN, NEW YORK, PENNSYLVANIA, OREGON, UTAH, WASHINGTON, AND WISCONSIN Order Regulating Handling Quality Control § 930.44 Quality control. (a) Quality standards. The Board may establish, with the approval of...

  3. 7 CFR 981.42 - Quality control.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Quality control. 981.42 Section 981.42 Agriculture... Regulating Handling Quality Control § 981.42 Quality control. (a) Incoming. Except as provided in this... establish, with the approval of the Secretary, such minimum quality and inspection requirements...

  4. A cluster randomized controlled trial aimed at implementation of local quality improvement collaboratives to improve prescribing and test ordering performance of general practitioners: Study Protocol

    PubMed Central

    Trietsch, Jasper; van der Weijden, Trudy; Verstappen, Wim; Janknegt, Rob; Muijrers, Paul; Winkens, Ron; van Steenkiste, Ben; Grol, Richard; Metsemakers, Job

    2009-01-01

    Background The use of guidelines in general practice is not optimal. Although evidence-based methods to improve guideline adherence are available, variation in physician adherence to general practice guidelines remains relatively high. The objective for this study is to transfer a quality improvement strategy based on audit, feedback, educational materials, and peer group discussion moderated by local opinion leaders to the field. The research questions are: is the multifaceted strategy implemented on a large scale as planned?; what is the effect on general practitioners' (GPs) test ordering and prescribing behaviour?; and what are the costs of implementing the strategy? Methods In order to evaluate the effects, costs and feasibility of this new strategy we plan a multi-centre cluster randomized controlled trial (RCT) with a balanced incomplete block design. Local GP groups in the south of the Netherlands already taking part in pharmacotherapeutic audit meeting groups, will be recruited by regional health officers. Approximately 50 groups of GPs will be randomly allocated to two arms. These GPs will be offered two different balanced sets of clinical topics. Each GP within a group will receive comparative feedback on test ordering and prescribing performance. The feedback will be discussed in the group and working agreements will be created after discussion of the guidelines and barriers to change. The data for the feedback will be collected from existing and newly formed databases, both at baseline and after one year. Discussion We are not aware of published studies on successes and failures of attempts to transfer to the stakeholders in the field a multifaceted strategy aimed at GPs' test ordering and prescribing behaviour. This pragmatic study will focus on compatibility with existing infrastructure, while permitting a certain degree of adaptation to local needs and routines. Trial registration Nederlands Trial Register ISRCTN40008171 PMID:19222840

  5. FIELD TEST OF THE FLAME QUALITY INDICATOR

    SciTech Connect

    Rudin, Andrew M; Butcher, Thomas; Troost, Henry

    2003-02-04

    The flame quality indicator concept was developed at BNL specifically to monitor the brightness of the flame in a small oil burner and to provide a ''call for service'' notification when the brightness has changed from its setpoint, either high or low. In prior development work BNL has explored the response of this system to operational upsets such as excess air changes, fouled atomizer nozzles, poor fuel quality, etc. Insight Technologies, Inc. and Honeywell, Inc. have licensed this technology from the U.S. Department of Energy and have been cooperating to develop product offerings which meet industry needs with an optimal combination of function and price. Honeywell has recently completed the development of the Flame Quality Monitor (FQM or Honeywell QS7100F). This is a small module which connects via a serial cable to the burners primary operating control. Primary advantages of this approach are simplicity, cost, and ease of installation. Call-for-service conditions are output in the form of front panel indicator lights and contact closure which can trigger a range of external communication options. Under this project a field test was conducted of the FQM in cooperation with service organizations in Virginia, Pennsylvania, New Jersey, New York, and Connecticut. At total of 83 field sites were included. At each site the FQM was installed in parallel with another embodiment of this concept--the Insight AFQI. The AFQI incorporates a modem and provides the ability to provide detailed information on the trends in the flame quality over the course of the two year test period. The test site population was comprised of 79.5% boilers, 13.7% warm air furnaces, and 6.8% water heaters. Nearly all were of residential size--with firing rates ranging from 0.6 gallons of oil per hour to 1.25. During the course of the test program the monitoring equipment successfully identified problems including: plugged fuel lines, fouled nozzles, collapsed combustion chambers, and poor fuel

  6. [Quality control in clinical trials].

    PubMed

    Fukushima, M

    1996-01-01

    Quality control (QC) in clinical trials means the procedures which insure protection of human subjects from research risk, reliability of the data, and thereby assures internal consistency. This has been developed since 1970s in the US, by establishing various regulations which are now called GCP. From the viewpoint of total QC, it should be emphasized that rigorous review of protocol by the Institutional Review Board and obtaining Informed Consent are prerequisites for insuring the quality of the given trial at high scientific level. When pursuing a clinical trial, first of all, facilities of the institutions and the ability of investigators must be of high quality. For this reason, at each institution previous data related to trials should be thoroughly reviewed and analyzed prior to developing a protocol. Educational courses in QC in clinical practice are invaluable. QC of diagnosis means, for example, central pathology review and standardization of diagnostic procedures and process. Secondly, at each institution, data managers collect the data and submit them to the central office at the indicated time. In order to evolve clinical trial, continuous education for data managers and expansion of their job are encouraged. Thirdly, at the statistical center independent from the research group office, subject-specific data managers, the biostatistical staff, must check submitted forms for completeness, consistency and accuracy. Finally, at the data analysis, quality evaluation of the research should also be carried out. Throughout the trial, monitoring and audit are particularly important to assure quality. The sponsor has the responsibility of monitoring the trial and make rigorous onsite visits, and the individual study group also have a monitoring program, while the FDA and the NCI audit by themselves. The purpose of audit is not only to assure data reliability but also to check out patient compliance to drug, education as to regulations and rules of clinical

  7. Research of data quality control based on quality grading

    NASA Astrophysics Data System (ADS)

    Liu, Shuang Hong; Yu, Jian Guo; Yu, Yong Ling

    2012-01-01

    To solve the problem of data quality in data warehouse, the process of data stream in data warehouse and the factors influencing data quality were analyzed; a method for controlling data quality based on quality grading was proposed and the frame of data quality grading system was established. In each process of ETL, the data quality grading system would execute script to calculate values, such as total, component and standard measures in accordance with the definition of Unit Measure, so as to get representation indexes; and then the quality report would be generated according to the indexes and the quality would be graded. The method is applicable to various data warehouse systems.

  8. Research of data quality control based on quality grading

    NASA Astrophysics Data System (ADS)

    Liu, Shuang Hong; Yu, Jian Guo; Yu, Yong Ling

    2011-12-01

    To solve the problem of data quality in data warehouse, the process of data stream in data warehouse and the factors influencing data quality were analyzed; a method for controlling data quality based on quality grading was proposed and the frame of data quality grading system was established. In each process of ETL, the data quality grading system would execute script to calculate values, such as total, component and standard measures in accordance with the definition of Unit Measure, so as to get representation indexes; and then the quality report would be generated according to the indexes and the quality would be graded. The method is applicable to various data warehouse systems.

  9. QUANTITY-QUALITY SIMULATION (QQS): A DETAILED CONTINUOUS PLANNING MODEL FOR URBAN RUNOFF CONTROL. VOLUME I. MODEL DESCRIPTION, TESTING, AND APPLICATIONS

    EPA Science Inventory

    A comprehensive mathematical model, the Quantity-Quality Simulation (QQS) model, for calculation of urban stormwater and combined sewer overflow pollution and the means for its control is presented. The model operates in a continuous mode with a five minute time step and accounts...

  10. 7 CFR 930.44 - Quality control.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 8 2013-01-01 2013-01-01 false Quality control. 930.44 Section 930.44 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING AGREEMENTS... Control § 930.44 Quality control. (a) Quality standards. The Board may establish, with the approval of...

  11. 14 CFR 21.139 - Quality control.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 1 2011-01-01 2011-01-01 false Quality control. 21.139 Section 21.139... PROCEDURES FOR PRODUCTS AND PARTS Production Certificates § 21.139 Quality control. The applicant must show that he has established and can maintain a quality control system for any product, for which...

  12. 7 CFR 981.42 - Quality control.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 8 2011-01-01 2011-01-01 false Quality control. 981.42 Section 981.42 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements... Regulating Handling Quality Control § 981.42 Quality control. (a) Incoming. Except as provided in...

  13. 7 CFR 930.44 - Quality control.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 8 2011-01-01 2011-01-01 false Quality control. 930.44 Section 930.44 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements... Control § 930.44 Quality control. (a) Quality standards. The Board may establish, with the approval of...

  14. 33 CFR 385.21 - Quality control.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 3 2010-07-01 2010-07-01 false Quality control. 385.21 Section... Processes § 385.21 Quality control. (a) The Corps of Engineers and the non-Federal sponsor shall prepare a quality control plan, in accordance with applicable Corps of Engineers regulations, for each product...

  15. 14 CFR 21.139 - Quality control.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Quality control. 21.139 Section 21.139... PROCEDURES FOR PRODUCTS AND PARTS Production Certificates § 21.139 Quality control. The applicant must show that he has established and can maintain a quality control system for any product, for which...

  16. Quality assurance and quality control in monitoring programs

    USGS Publications Warehouse

    Shampine, W.J.

    1993-01-01

    There are three general characteristics of the data to be collected in a monitoring program that should be met in order to maximize the use and value of the data: the data quality should be known the data type and quality should be consistent and comparable, and the data should be available and accessible. Potential problems with each of these characteristics are addressed effectively by quality assurance and quality control. One of the most important aspects of quality assurance in a monitoring program is the development of a quality assurance plan, which should identify clearly the quality of the data needed and describe in detail the planned actions to provide confidence that the program will meet its stated objectives. Quality control data, which allow for the quality and suitability of the environmental data to be evaluated and ascertained, should be collected and utilized as an integral part of the QA effort associated with a monitoring program.

  17. Business quality control in issuing life insurance.

    PubMed

    Roberts, N K

    1999-01-01

    Fraud investigation and fraud control are entirely different processes. Similarly the auditing of a life insurance company and the issuing of life insurance policies and business quality control are not the same. Business quality control and fraud control have much in common. In this article, these similarities are explored and a case is made that companies issuing life insurance policies should consider the business quality control approach rather than the more traditional investigatory methods. PMID:10539385

  18. Quality Control of EUVE Databases

    NASA Astrophysics Data System (ADS)

    John, Linda M.

    1993-01-01

    The publicly accessible databases for the Extreme Ultraviolet Explorer (EUVE) include: the EUVE Archive Mailserver, the Center for EUV Astrophysics ftp site, the EUVE Guest Observer Mailserver, and the Astronomical Data System node. The EUVE Performance Assurance team is responsible for verifying that these public databases are working properly and that the public availability of EUVE data contained therein does not infringe any data rights which may have been assigned. In this paper, we describe the quality assurance (QA) procedures we have developed from approaching QA as a service organization; this approach reflects the overall EUVE philosophy of QA integrated into normal operating procedures, rather than imposed as an external, post-facto, control mechanism.

  19. Test and inspection for process control of monolithic circuits

    NASA Technical Reports Server (NTRS)

    Spangenberg, E.

    1967-01-01

    Report details the test and inspection procedures for the mass production of high reliability integrated circuits. It covers configuration control, basic fundamentals of quality control, control charts, wafer process evaluation, general process evaluation, evaluation score system, and diffusion evaluation.

  20. A Six-Year Predictive Test of Adolescent Family Relationship Quality and Effortful Control Pathways to Emerging Adult Social and Emotional Health

    PubMed Central

    Fosco, Gregory M.; Caruthers, Allison S.; Dishion, Thomas J.

    2012-01-01

    This longitudinal study examined how a multimethod (youth report, parent report, direct observation) assessment of family relationship quality (cohesion and conflict) in adolescence (age 16 –17) predicted growth and maintenance of effortful control across ages 17, 22, and 23 years old, and, ultimately, subjective well-being, emotional distress, and aggressive behavior in emerging adulthood (23). A diverse sample of 792 youth at age 17 and their families, and youth at ages 22 and 23, were studied to examine family cohesion and conflict and the growth and maintenance of effortful control as predictors of emerging adult social and emotional health. Results indicated that family cohesion and conflict during late adolescence and mean-level effortful control at age 22 each served as unique pathways to emerging adult adjustment. These findings underscore the importance of family functioning during adolescence and the maintenance of effortful control into emerging adulthood for understanding adjustment during the emerging adulthood period. PMID:22709261

  1. 40 CFR 136.7 - Quality assurance and quality control.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 24 2012-07-01 2012-07-01 false Quality assurance and quality control. 136.7 Section 136.7 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER... referred to as a spiked blank, or laboratory control sample (LCS); (v) Matrix spike (MS) and matrix...

  2. Development of an in vitro antigen-detection test as an alternative method to the in vivo plaque reduction neutralization test for the quality control of Japanese encephalitis virus vaccine.

    PubMed

    Kim, Do Keun; Kim, Hye-Youn; Kim, Joo-Young; Ye, Michael B; Park, Kee-Bum; Han, Euiri; Kim, Jaeok; Ja Ban, Sang; Hong, Seung Hwa; Park, Yong Keun; Nam, Jae-Hwan

    2012-07-01

    Japanese encephalitis virus (JEV) causes diseases that attack the human central nervous system. Traditionally, the quality control for JEV vaccines, in which the plaque reduction neutralization (PRN) titer is measured by the national control laboratories before the vaccine batches are marketed, has required laboratory animal testing. However, classical animal tests have inherent problems, including the very fact that animals are used, ethical issues, and the possibility of error. In this study, JEV antigen was measured in an in vitro assay to assess the feasibility of replacing in vivo assays that measure the PRN titers of JEV vaccines. We constructed a double-sandwich enzyme-linked immunosorbent assay (DS-ELISA) that could detect JEV envelope (E). Initially, monoclonal antibodies (mAbs) directed against the JEV E protein were generated and characterized. We isolated 18 mAbs against JEV E protein, and most were the IgG1 or IgG2a isotype. The mAbs (5F15 and 7D71) were selected as the most suitable mAb pair to detect JEV E protein. DS-ELISA with this pair detected as little as approximately 3 μg/mL JEV E protein and demonstrated a relationship between the amount of JEV E protein and the PRN titer. From these results, we surmise that this DS-ELISA may be useful, not only in terms of measuring the amount of JEV E protein, but also as a substitute for the PRN test for JEV vaccine evaluation. PMID:22486472

  3. QUALITY CONTROL - VARIABILITY IN PROTOCOLS

    EPA Science Inventory

    The EPA Risk Reduction Engineering Laboratory’s Quality Assurance Office, which published the popular pocket guide Preparing Perfect Project Plans, is now introducing another quality assurance reference aid. The document Variability in Protocols (VIP) was initially designed as a ...

  4. [Seed quality test methods of Paeonia suffruticosa].

    PubMed

    Cao, Ya-Yue; Zhu, Zai-Biao; Guo, Qiao-Sheng; Liu, Li; Wang, Chang-Lin

    2014-11-01

    In order to optimize the testing methods for Paeonia suffruticosa seed quality, and provide basis for establishing seed testing rules and seed quality standard of P. suffruticosa. The seed quality of P. suffruticosa from different producing areas was measured based on the related seed testing regulations. The seed testing methods for quality items of P. suffruticosa was established preliminarily. The samples weight of P. suffruticosa was at least 7 000 g for purity analysis and was at least 700 g for test. The phenotypic observation and size measurement were used for authenticity testing. The 1 000-seed weight was determined by 100-seed method, and the water content was carried out by low temperature drying method (10 hours). After soaking in distilled water for 24 h, the seeds was treated with different temperature stratifications of day and night (25 degrees C/20 degrees C, day/night) in the dark for 60 d. After soaking in the liquor of GA3 300 mg x L(-1) for 24 h, the P. suffruticos seeds were cultured in wet sand at 15 degrees C for 12-60 days for germination testing. Seed viability was tested by TlC method. PMID:25775790

  5. Computers and quality control in nuclear medicine.

    PubMed

    Brookeman, V A

    1978-04-01

    The general topic of computers and nuclear medicine quality control may be approached from two main areas; controlling the quality of computerized studies, and computer applications in general nuclear medicine quality control. Overlap occurs when quality control of computer studies is performed by the computer itself. The uses of computers in record-keeping and in quality control of imaging instrumentation and in vitro studies, including radioimmunoassay, are discussed in this review. Aspects of quality control for computerized clinical cardiovascular, cerebral, and renal studies and emission computed tomography are reviewed, including consideration of difficulties and inaccuracies involved in the studies. Any automatic computer analysis program should incorporate adequate checks and error detection protocols and should illustrate results for verification. Current routine quality control procedures using the computer unfortunately are few. Quality control criteria are needed for camera/computer systems in high count rate clinical applications, and increasing emphasis should be aimed at quality control of those computerized dynamic and function studies in current clinical use. The computer has a valuable potential for nuclear medicine quality control. In vitro and computerized in vivo studies can be analyzed by readily available statistical programs, and variances can be monitored continuously. Computers can calibrate and monitor instrument performance regularly, and can handle managerial and clerical duties such as bookkeeping. PMID:684439

  6. A quality control program for waste disposal vault closure

    SciTech Connect

    Benny, H.L.

    1994-07-01

    This paper provides a review of the quality control program employed for closure for a radioactive waste disposal vault at Hanford Washington. The major elements of the program are discussed, as well as the testing results and lessons learned.

  7. Optimization and quality control of computed radiography

    NASA Astrophysics Data System (ADS)

    Willis, Charles E.; Weiser, John C.; Leckie, Robert G.; Romlein, John R.; Norton, Gary S.

    1994-05-01

    Computed radiography (CR) is a relatively new technique for projection radiography. Few hospitals have CR devices in routine service and only a handful have more than one CR unit. As such, the clinical knowledge base does not yet exist to establish quality control (QC) procedures for CR devices. Without assurance that CR systems are operating within nominal limits, efforts to optimize CR performance are limited in value. A complete CR system includes detector plates that vary in response, cassettes, an electro-optical system for developing the image, computer algorithms for processing the raw image, and a hard copy output device. All of these subsystems are subject to variations in performance that can degrade image quality. Using CR manufacturer documentation, we have defined acceptance protocols for two different Fuji CR devices, the FCR 7000 and the AC1+, and have applied these tests to ten individual machines. We have begun to establish baseline performance measures and to determine measurement frequencies. CR QC is only one component of the overall quality control for totally digital radiology departments.

  8. Quality Control in Small Groups

    NASA Astrophysics Data System (ADS)

    Lemmens, L. F.

    2008-11-01

    The smallness of some groups in a set up to control the quality of a service using questionnaires limits the size of the samples, this limitation has several consequences. Indeed the common approach used for relatively large groups, based on the central limit theorem and the law of large numbers, cannot be used anymore to construct estimators for the parameters of the model. Using an inverse probability will lift these restrictions. A questionnaire is a collection of items. In an item the respondent indicates on a Likert scale his or her agreement with a statement. Dimensions are a set of items dealing with one aspect of the service. In a questionnaire several dimensions are addressed but usually the items are presented in a random sequence. The model for an item is hierarchical with following components: a multivariate hypergeometric model takes the sampling in a finite population into account, the multinomial serves as a prior for the sampling and the Dirichlet-distribution serves as a prior for the multinomials. The composition of dimensions allows to use the posterior for one of the items as a prior for another item of that dimension and so on. After analysis of several questionnaires using this model, the reliability of the responses from some respondents turned out to be a key-problem, in the sense the responses can be classified into at least two classes and a decision rule had to be developed to neglect some of them. The influence of rejecting some answers, on the confidence for the most plausible statement can be estimated. This leads often to the result that there is only minimal evidence for the most probable statement.

  9. Colorado Air Quality Control Regulations and Ambient Air Quality Standards.

    ERIC Educational Resources Information Center

    Colorado State Dept. of Health, Denver. Div. of Air Pollution Control.

    Regulations and standards relative to air quality control in Colorado are defined in this publication. Presented first are definitions of terms, a statement of intent, and general provisions applicable to all emission control regulations adopted by the Colorado Air Pollution Control Commission. Following this, three regulations are enumerated: (1)…

  10. 30 CFR 74.6 - Quality control.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Quality control. 74.6 Section 74.6 Mineral... DUST SAMPLING DEVICES Approval Requirements for Coal Mine Dust Personal Sampler Unit § 74.6 Quality... to maintain its quality prior to assembly of each sampler unit. In order to assure that the...

  11. Handling qualities requirements for control configured vehicles

    NASA Technical Reports Server (NTRS)

    Woodcock, R. J.; George, F. L.

    1976-01-01

    The potential effects of fly by wire and control configured vehicle concepts on flying qualities are considered. Failure mode probabilities and consequences, controllability, and dynamics of highly augmented aircraft are among the factors discussed in terms of design criteria.

  12. Quality control education in the community college

    NASA Technical Reports Server (NTRS)

    Greene, J. Griffen; Wilson, Steve

    1966-01-01

    This paper describes the Quality Control Program at Daytona Beach Junior College, including course descriptions. The program in quality control required communication between the college and the American Society for Quality Control (ASQC). The college has machinery established for certification of the learning process, and the society has the source of teachers who are competent in the technical field and who are the employers of the educational products. The associate degree for quality control does not have a fixed program, which can serve all needs, any more than all engineering degrees have identical programs. The main ideas which would be common to all quality control programs are the concept of economic control of a repetitive process and the concept of developing individual potentialities into individuals who are needed and productive.

  13. TESTS OF INDOOR AIR QUALITY SINKS

    EPA Science Inventory

    Experiments were conducted in a room-size test chamber to determine the sink effects of selected materials on indoor air concentrations of p-dichlorobenzene (PDCB). hese effects might alter pollutant behavior from that predicted using similar indoor air quality models, by reducin...

  14. 30 CFR 28.31 - Quality control plans; contents.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 28.31 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR TESTING...) Each quality control plan shall contain provisions for the management of quality, including: (1... Specification MIL-F-15160D is available for examination at the U.S. Department of Labor, Mine Safety and...

  15. 30 CFR 28.31 - Quality control plans; contents.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 28.31 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR TESTING...) Each quality control plan shall contain provisions for the management of quality, including: (1... Specification MIL-F-15160D is available for examination at the U.S. Department of Labor, Mine Safety and...

  16. Spacecraft Attitude and Orbit Control Systems testing

    NASA Astrophysics Data System (ADS)

    Sonnenschein, F. J.; Schoomade, M.; Zwartbol, T.

    1995-03-01

    Contemporary AOCS are equipped with local Attitude Control Computers which provide sophisticated Attitude and Orbit Control functions, automatic Failure Detection and Isolation functions and extensive Telemetry and Telecommand handling functions. Generic models of the design, development and test life cycle approaches for such intelligent AOCS are emerging. Also knowledge of the activities to be performed and the generic design, development and test environments to be used during the different phases is accumulating. Lessons learned can be used to improve AOCS development life cycle approaches and to define new development and test environments which improve the efficiency of the design, development and test life cycle and quality of the product. The SAX (Satellite per Astronomia a raggi X) satellite is equipped with a contemporary AOCS providing the above mentioned functions. In this paper the SAX AOCS software design, development and test life cycle is described as an example of AOCS software development. Lessons learned and suggestions for possible improvements are given.

  17. Professional Development for Water Quality Control Personnel.

    ERIC Educational Resources Information Center

    Shepard, Clinton Lewis

    This study investigated the availability of professional development opportunities for water quality control personnel in the midwest. The major objective of the study was to establish a listing of educational opportunities for the professional development of water quality control personnel and to compare these with the opportunities technicians…

  18. 33 CFR 385.21 - Quality control.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... DEFENSE PROGRAMMATIC REGULATIONS FOR THE COMPREHENSIVE EVERGLADES RESTORATION PLAN CERP Implementation... quality control plan, in accordance with applicable Corps of Engineers regulations, for each product that will be produced by a Project Delivery Team. The quality control plan shall be included in the...

  19. Quality Control Technician Curriculum. An Elusive Butterfly.

    ERIC Educational Resources Information Center

    Holler, Michael

    Defining and developing a quality control technician curriculum for an associate degree program is a difficult and puzzling job. There are as many definitions of quality control and curriculum ideas as there are educators asked. However, one could start by dividing the field into its major areas--heavy manufacturing, maintenance, research, and…

  20. 30 CFR 74.6 - Quality control.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 30 Mineral Resources 1 2011-07-01 2011-07-01 false Quality control. 74.6 Section 74.6 Mineral... of the CMDPSU will be maintained in production through adequate quality control procedures, MSHA and... DUST SAMPLING DEVICES Approval Requirements for Coal Mine Dust Personal Sampler Unit § 74.6...

  1. Iowa Central Quality Fuel Testing Laboratory

    SciTech Connect

    Heach, Don; Bidieman, Julaine

    2013-09-30

    The objective of this project is to finalize the creation of an independent quality fuel testing laboratory on the campus of Iowa Central Community College in Fort Dodge, Iowa that shall provide the exploding biofuels industry a timely and cost-effective centrally located laboratory to complete all state and federal fuel and related tests that are required. The recipient shall work with various state regulatory agencies, biofuel companies and state and national industry associations to ensure that training and testing needs of their members and American consumers are met. The recipient shall work with the Iowa Department of Ag and Land Stewardship on the development of an Iowa Biofuel Quality Standard along with the Development of a standard that can be used throughout industry.

  2. Quality-control analytical methods: continuous quality improvement.

    PubMed

    Venti, Eden M

    2006-01-01

    It is vital that all compounding pharmacies have a continuous quality improvement program in place by way of standard operating procedures to assure that patients receive high-quality preparations. The program should take into consideration any federal and state regulatory requirements, as well as professional association expectations. Quality control measurements and regular review of those measurements are the foundations of a good quality plan. All pharmacy personnel should be aware of the importance of reporting potential internal quality concerns or problems and should be encouraged to do so without fear of repercussions. Ideally, an error-free compounding pracitice would be the goal. Since this is not practical, quality issues should not be viewed as problems, but as opportunities to improve compounding practices by correcting, before they become pervasive, the processes used in the preparation of prescriptions. PMID:23974418

  3. Quality Assurance and Quality Control Practices for Rehabilitation of Sewer and Water Mains

    EPA Science Inventory

    As part of the US Environmental Protection Agency (EPA)’s Aging Water Infrastructure Research Program, several areas of research are being pursued, including a review of quality assurance and quality control (QA/QC) practices and acceptance testing during the installation of reha...

  4. Quality Assurance and Quality Control Practices For Rehabilitation of Sewer and Water Mains

    EPA Science Inventory

    As part of the US Environmental Protection Agency (EPA)’s Aging Water Infrastructure Research Program, several areas of research are being pursued including a review of quality assurance and quality control (QA/QC) practices and acceptance testing during the installation of rehab...

  5. Water Quality Control, Curriculum Guide.

    ERIC Educational Resources Information Center

    Washington City Board of Education, NC.

    Activities which study how water is used, contaminated, and treated or purified are presented in this curriculum guide, culminating in the investigation of a local water quality problem. Designed as a 12 week mini-course for students in grades eight and nine, the guide first presents a review of the content, objectives, major concepts, and sources…

  6. Dose Calibrator Linearity Testing: Radioisotope 99mTc or 18F? An Alternative for Reducing Costs in Nuclear Medicine Quality Control

    PubMed Central

    Willegaignon, José; Sapienza, Marcelo T.; Coura-Filho, George Barberio; Garcez, Alexandre T.; Alves, Carlos E.; Cardona, Marissa R.; Gutterres, Ricardo F.; Buchpiguel, Carlos A.

    2015-01-01

    Dose calibrator linearity testing is indispensable for evaluating the capacity of this equipment in measuring radioisotope activities at different magnitudes, a fundamental aspect of the daily routine of a nuclear medicine department, and with an impact on patient exposure. The main aims of this study were to evaluate the feasibility of substituting the radioisotope Fluorine-18 (18F) with Technetium-99m (99mTc) in this test, and to indicate it with the lowest operational cost. The test was applied with sources of 99mTc (62 GBq) and 18F (12 GBq), the activities of which were measured at different times, with the equipment preadjusted to measuring sources of 99mTc, 18F, Gallium-67 (67Ga), and Iodine-131 (131I). Over time, the average deviation between measured and expected activities from 99mTc and 18F were, respectively, 0.56 (±1.79)% and 0.92 (±1.19)%. The average ratios for 99mTc source experimental activity, when measured with the equipment adjusted for measuring 18F, 67Ga, and 131I sources, in real values, were, respectively, 3.42 (±0.06), 1.45 (±0.03), and 1.13 (±0.02), and those for the 18F source experimental activity, measured through adjustments of 99mTc, 67Ga, and 131I, were, respectively, 0.295 (±0.004), 0.335 (±0.007), and 0.426 (±0.006). The adjustment of a simple exponential function for describing 99mTc and 18F experimental activities facilitated the calculation of the physical half-lives of the radioisotopes, with a difference of about 1% in relation to the values described in the literature. Linearity test results, when using 99mTc, through being compatible with those acquired with 18F, imply the possibility of using both radioisotopes during linearity testing. Nevertheless, this information, along with the high potential of exposure and the high cost of 18F, implies that 99mTc should preferably be employed for linearity testing in clinics that normally use 18F, without the risk of prejudicing either the procedure itself or the guarantee of

  7. 21 CFR 862.1660 - Quality control material (assayed and unassayed).

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 8 2011-04-01 2011-04-01 false Quality control material (assayed and unassayed... Test Systems § 862.1660 Quality control material (assayed and unassayed). (a) Identification. A quality... that may arise from reagent or analytical instrument variation. A quality control material (assayed...

  8. 21 CFR 862.1660 - Quality control material (assayed and unassayed).

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Quality control material (assayed and unassayed... Test Systems § 862.1660 Quality control material (assayed and unassayed). (a) Identification. A quality... that may arise from reagent or analytical instrument variation. A quality control material (assayed...

  9. Control by quality: proposition of a typology.

    PubMed

    Pujo, P; Pillet, M

    The application of Quality tools and methods in industrial management has always had a fundamental impact on the control of production. It influences the behavior of the actors concerned, while introducing the necessary notions and formalizations, especially for production systems with little or no automation, which constitute a large part of the industrial activity. Several quality approaches are applied in the workshop and are implemented at the level of the control. In this paper, the authors present a typology of the various approaches that have successively influenced control, such as statistical process control, quality assurance, and continuous improvement. First the authors present a parallel between production control and quality organizational structure. They note the duality between control, which is aimed at increasing productivity, and quality, which aims to satisfy the needs of the customer. They also note the hierarchical organizational structure of these two systems of management with, at each level, the notion of a feedback loop. This notion is fundamental to any kind of decision making. The paper is organized around the operational, tactical, and strategic levels, by describing for each level the main methods and tools for control by quality. The overview of these tools and methods starts at the operational level, with the Statistical Process Control, the Taguchi technique, and the "six sigma" approach. On the tactical level, we find a quality system approach, with a documented description of the procedures introduced in the firm. The management system can refer here to Quality Assurance, Total Productive Maintenance, or Management by Total Quality. The formalization through procedures of the rules of decision governing the process control enhances the validity of these rules. This leads to the enhancement of their reliability and to their consolidation. All this counterbalances the human, intrinsically fluctuating, behavior of the control

  10. New Test Set for Video Quality Benchmarking

    NASA Astrophysics Data System (ADS)

    Raventos, Joaquin

    A new test set design and benchmarking approach (US Patent pending) allows a "standard observer" to assess the end-to-end image quality characteristics of video imaging systems operating in day time or low-light conditions. It uses randomized targets based on extensive application of Photometry, Geometrical Optics, and Digital Media. The benchmarking takes into account the target's contrast sensitivity, its color characteristics, and several aspects of human vision such as visual acuity and dynamic response. The standard observer is part of the "extended video imaging system" (EVIS). The new test set allows image quality benchmarking by a panel of standard observers at the same time. The new approach shows that an unbiased assessment can be guaranteed. Manufacturers, system integrators, and end users will assess end-to-end performance by simulating a choice of different colors, luminance levels, and dynamic conditions in the laboratory or in permanent video systems installations.

  11. [Comparing quality measurements Part 2: control charts].

    PubMed

    Kottner, Jan; Hauss, Armin

    2013-04-01

    Comparative quality measurements and evaluations in nursing play significant roles. Quality measures are affected by systematic and random error. Statistical Process Control (SPC) offers a method to take random variation adequately into account. In this article, control charts are introduced. Those are graphical displays to show quality measures over time. Attribute variables can be displayed by p-, u- and c-control charts. Special cause variations within the processes can be detected by rules. If signs for special cause variations are absent, the process in considered being in statistical control showing common cause variation. A deviation of one data point greater than three standard deviations from the arithmetic mean is considered the strongest signal for non random variation within the process. Within quality improvement contexts control charts outperform traditional comparisons of means and spreads. PMID:23535476

  12. Multivariate tests for trend in water quality

    NASA Astrophysics Data System (ADS)

    Loftis, Jim C.; Taylor, Charles H.; Chapman, Phillip L.

    1991-07-01

    Several methods of testing for multivariate trend have been discussed in the statistical and water quality literature. We review both parametric and nonparametric approaches and compare their performance using, synthetic data. A new method, based on a robust estimation and testing approach suggested by Sen and Puri, performed very well for serially independent observations. A modified version of the covariance inversion approach presented by Dietz and Killeen also performed well for serially independent observations. For serially correlated observations, the covariance eigenvalue method suggested by Lettenmaier was the best performer.

  13. Quality control of antibodies for assay development.

    PubMed

    Schumacher, Sarah; Seitz, Harald

    2016-09-25

    Antibodies are used as powerful tools in basic research, for example, in biomarker identification, and in various forms for diagnostics, for example, identification of allergies or autoimmune diseases. Due to their robustness and ease of handling, immunoassays are favourite methods for investigation of various biological or medical questions. Nevertheless in many cases, additional analyses such as mass spectrometry are used to validate or confirm the results of immunoassays. To minimize the workload and to increase confidence in immunoassays, there are urgent needs for antibodies which are both highly specific and well validated. Unfortunately many commercially available antibodies are neither well characterized nor fully tested for cross-reactivities. Adequate quality control and validation of an antibody is time-consuming and can be frustrating. Such validation needs to be performed for every assay/application. However, where an antibody validation is successful, a highly specific and stable reagent will be on hand. This article describes the validation processes of antibodies, including some often neglected factors, as well as unspecific binding to other sample compounds in a multiparameter diagnostic assay. The validation consists of different immunological methods, with important assay controls, and is performed in relation to the development of a diagnostic test. PMID:26873787

  14. Quality Control Using Optical Probe Arrays

    NASA Astrophysics Data System (ADS)

    Stewart, Robert M.

    1989-01-01

    Low cost, optical probes, can be combined into an inspection array, and the go/no-go outputs can be analyzed by a high speed programmable logic controller (PLC). The PLC can be remotely addressed to change the desired level of quality control. The PLC can provide on-line data for blow-by-blow statistical process control (SPC).

  15. FIELD QUALITY CONTROL STRATEGIES ASSESSING SOLIDIFICATION/STABILIZATION

    EPA Science Inventory

    Existing regulatory mobility reduction (leaching) tests are not amenable to real time quality control because of the time required to perform sample extraction and chemical analysis. This is of conccern because the leaching test is the most important parameter used to relate trea...

  16. On the Need for Quality Control in Validation Research.

    ERIC Educational Resources Information Center

    Maier, Milton H.

    1988-01-01

    Validated aptitude tests used to help make personnel decisions about military recruits against hands-on tests of job performance in radio repairers and automotive mechanics. Data were filled with errors, reducing accuracy of validity coefficients. Discusses how validity coefficients can be made more accurate by exercising quality control during…

  17. NIF Projects Controls and Information Systems Software Quality Assurance Plan

    SciTech Connect

    Fishler, B

    2011-03-18

    Quality achievement for the National Ignition Facility (NIF) and the National Ignition Campaign (NIC) is the responsibility of the NIF Projects line organization as described in the NIF and Photon Science Directorate Quality Assurance Plan (NIF QA Plan). This Software Quality Assurance Plan (SQAP) is subordinate to the NIF QA Plan and establishes quality assurance (QA) activities for the software subsystems within Controls and Information Systems (CIS). This SQAP implements an activity level software quality assurance plan for NIF Projects as required by the LLNL Institutional Software Quality Assurance Program (ISQAP). Planned QA activities help achieve, assess, and maintain appropriate quality of software developed and/or acquired for control systems, shot data systems, laser performance modeling systems, business applications, industrial control and safety systems, and information technology systems. The objective of this SQAP is to ensure that appropriate controls are developed and implemented for management planning, work execution, and quality assessment of the CIS organization's software activities. The CIS line organization places special QA emphasis on rigorous configuration control, change management, testing, and issue tracking to help achieve its quality goals.

  18. Aircraft flight test trajectory control

    NASA Technical Reports Server (NTRS)

    Menon, P. K. A.; Walker, R. A.

    1988-01-01

    Two design techniques for linear flight test trajectory controllers (FTTCs) are described: Eigenstructure assignment and the minimum error excitation technique. The two techniques are used to design FTTCs for an F-15 aircraft model for eight different maneuvers at thirty different flight conditions. An evaluation of the FTTCs is presented.

  19. Quality Control Systems in Cardiac Aging

    PubMed Central

    Quarles, Ellen K; Dai, Dao-Fu; Tocchi, Autumn; Basisty, Nathan; Gitari, Lemuel; Rabinovitch, Peter S

    2015-01-01

    Cardiac aging is an intrinsic process that results in impaired cardiac function, along with cellular and molecular changes. These degenerative changes are intimately associated with quality control mechanisms. This review provides a general overview of the clinical and cellular changes which manifest in cardiac aging, and the quality control mechanisms involved in maintaining homeostasis and retarding aging. These mechanisms include autophagy, ubiquitin-mediated turnover, apoptosis, mitochondrial quality control and cardiac matrix homeostasis. Finally, we discuss aging interventions that have been observed to impact cardiac health outcomes. These include caloric restriction, rapamycin, resveratrol, GDF11, mitochondrial antioxidants and cardiolipin-targeted therapeutics. A greater understanding of the quality control mechanisms that promote cardiac homeostasis will help to understand the benefits of these interventions, and hopefully lead to further improved therapeutic modalities. PMID:25702865

  20. Tools for quality control of fingerprint databases

    NASA Astrophysics Data System (ADS)

    Swann, B. Scott; Libert, John M.; Lepley, Margaret A.

    2010-04-01

    Integrity of fingerprint data is essential to biometric and forensic applications. Accordingly, the FBI's Criminal Justice Information Services (CJIS) Division has sponsored development of software tools to facilitate quality control functions relative to maintaining its fingerprint data assets inherent to the Integrated Automated Fingerprint Identification System (IAFIS) and Next Generation Identification (NGI). This paper provides an introduction of two such tools. The first FBI-sponsored tool was developed by the National Institute of Standards and Technology (NIST) and examines and detects the spectral signature of the ridge-flow structure characteristic of friction ridge skin. The Spectral Image Validation/Verification (SIVV) utility differentiates fingerprints from non-fingerprints, including blank frames or segmentation failures erroneously included in data; provides a "first look" at image quality; and can identify anomalies in sample rates of scanned images. The SIVV utility might detect errors in individual 10-print fingerprints inaccurately segmented from the flat, multi-finger image acquired by one of the automated collection systems increasing in availability and usage. In such cases, the lost fingerprint can be recovered by re-segmentation from the now compressed multi-finger image record. The second FBI-sponsored tool, CropCoeff was developed by MITRE and thoroughly tested via NIST. CropCoeff enables cropping of the replacement single print directly from the compressed data file, thus avoiding decompression and recompression of images that might degrade fingerprint features necessary for matching.

  1. Quality control of automated cell counters.

    PubMed

    Cembrowski, George S; Clarke, Gwen

    2015-03-01

    The hematology analyzers of today provide more reproducible analyses compared with those of a few decades ago, necessitating an evolution in hematology quality practices. The improved performance allows use of simple quality control rules. This improved performance also renders the repeat analysis of critical value specimens non value added. Some of the patient averaging techniques have become outmoded and need to be replaced by less complicated calculations but with truncation of predictable outlying populations. The ready availability of comparative peer quality control values helps to improve analyzer precision and accuracy, and simplifies instrument validation and calibration. PMID:25676372

  2. Building Controls Virtual Test Bed

    SciTech Connect

    Wetter, Michael; Haves, Philip; Coffey, Brian

    2008-04-01

    The Building Controls Virtual Test Bed (BCVTB) is a modular software environment that is based on the Ptolemy II software environment. The BCVTB can be used for design and analysis of heterogenous systems, such as building energy and controls systems. Our additions to Ptolemy II allow users to Couple to Ptolemy II simulation software such as EnergyPlus, MATLAB/Simulink or Dymola for data exchange during run-time. Future versions of the BCVTS will also contain an interface to BACnet which is a communication protocol for building Control systems, and interfaces to digital/analog converters that allow communication with controls hardware. Through Ptolemy II, the BCVTB provides a graphical model building environment, synchronizes the exchanged data and visualizes the system evolution during run- time.

  3. Building Controls Virtual Test Bed

    Energy Science and Technology Software Center (ESTSC)

    2008-04-01

    The Building Controls Virtual Test Bed (BCVTB) is a modular software environment that is based on the Ptolemy II software environment. The BCVTB can be used for design and analysis of heterogenous systems, such as building energy and controls systems. Our additions to Ptolemy II allow users to Couple to Ptolemy II simulation software such as EnergyPlus, MATLAB/Simulink or Dymola for data exchange during run-time. Future versions of the BCVTS will also contain an interfacemore » to BACnet which is a communication protocol for building Control systems, and interfaces to digital/analog converters that allow communication with controls hardware. Through Ptolemy II, the BCVTB provides a graphical model building environment, synchronizes the exchanged data and visualizes the system evolution during run- time.« less

  4. Flight test trajectory control analysis

    NASA Technical Reports Server (NTRS)

    Walker, R.; Gupta, N.

    1983-01-01

    Recent extensions to optimal control theory applied to meaningful linear models with sufficiently flexible software tools provide powerful techniques for designing flight test trajectory controllers (FTTCs). This report describes the principal steps for systematic development of flight trajectory controllers, which can be summarized as planning, modeling, designing, and validating a trajectory controller. The techniques have been kept as general as possible and should apply to a wide range of problems where quantities must be computed and displayed to a pilot to improve pilot effectiveness and to reduce workload and fatigue. To illustrate the approach, a detailed trajectory guidance law is developed and demonstrated for the F-15 aircraft flying the zoom-and-pushover maneuver.

  5. [The quality of biological information: standardization and quality control].

    PubMed

    Giampaoli, S; Muti, P

    1992-01-01

    Some procedures and methods for the measurement of cardiovascular risk factor are described; in particular of anthropometric measurements (weight, height, arm circumference, wrist circumference, hip circumference) of blood pressure, of electrocardiogram and of blood samples for the preservation of biological specimens. Some advice for the quality control during screening activities are reported. PMID:1492736

  6. QUALITY ASSURANCE AND QUALITY CONTROL FOR RADIOCHEMICAL ANALYSES AND MEASUREMENTS

    EPA Science Inventory

    Require that each batch of samples analyzed be accompanied by appropriate quality control samples to evaluate accuracy and precision of the results. Require a documented data review and validation process by a minimum of three people before data is released to the client. Requi...

  7. Network-based production quality control

    NASA Astrophysics Data System (ADS)

    Kwon, Yongjin; Tseng, Bill; Chiou, Richard

    2007-09-01

    This study investigates the feasibility of remote quality control using a host of advanced automation equipment with Internet accessibility. Recent emphasis on product quality and reduction of waste stems from the dynamic, globalized and customer-driven market, which brings opportunities and threats to companies, depending on the response speed and production strategies. The current trends in industry also include a wide spread of distributed manufacturing systems, where design, production, and management facilities are geographically dispersed. This situation mandates not only the accessibility to remotely located production equipment for monitoring and control, but efficient means of responding to changing environment to counter process variations and diverse customer demands. To compete under such an environment, companies are striving to achieve 100%, sensor-based, automated inspection for zero-defect manufacturing. In this study, the Internet-based quality control scheme is referred to as "E-Quality for Manufacturing" or "EQM" for short. By its definition, EQM refers to a holistic approach to design and to embed efficient quality control functions in the context of network integrated manufacturing systems. Such system let designers located far away from the production facility to monitor, control and adjust the quality inspection processes as production design evolves.

  8. Testing fruit quality by photoacoustic spectroscopy assay

    NASA Astrophysics Data System (ADS)

    Popa, C.; Dumitras, D. C.; Patachia, M.; Banita, S.

    2014-10-01

    This study was conducted with the aim of testing the hypothesis that raspberry and strawberry fruits from nonorganic farming release more ethylene gas compounds compared to organic ones. At the same time, the experiments focused on evaluation of the potential and capabilities of the laser photoacoustic spectroscopy (LPAS) method in the assessment of fruit quality related to the effects of nitrogen. Ethylene gas can be harmful and carcinogenic, because it can accelerate the natural ripening process of physiologically mature fruits and makes the fruits more consistent in size. With the advantages of LPAS, we demonstrate that the concentration of ethylene from nonorganic raspberry and strawberry fruits is greater than from organic ones.

  9. Quality control loop for 3D laser beam cutting

    NASA Astrophysics Data System (ADS)

    Spitznagel, Juergen

    1996-08-01

    Existing systems for computer integrated manufacturing are based on the principle of the process chain: The product runs through different production sections as design, work planning and manufacturing in a sequential order. The data generated by a production sequence are transferred via interface to the following production sequence. These tightly-packed production sequences leave little scope for responding to quality deviations. This deficit is highlighted particularly in 3D laser cutting processes. In order to achieve an optimum machining result, a series of preliminary tests is required. Quality control loops play an important role in restricting the scope of necessary testing to a minimum. The represented control loop contains a CAD- system to design the workpiece, an offline-programming system to develop working strategies and NC/RC-programs as well as a shop-floor oriented tool to record quality data of the workpiece. The systems are coupled by an integrated product model. The control loop feeds quality data back to Operations Planning in the form of rules for processing strategies and technological data, so that the quality of the production process is enhanced. It is intended to supply optimum process parameters, so that the number of preliminary tests can be reduced. On the other hand the control loop contributes quality enhancement measures which serve as rules for the designers.

  10. Toward standardising gamma camera quality control procedures

    NASA Astrophysics Data System (ADS)

    Alkhorayef, M. A.; Alnaaimi, M. A.; Alduaij, M. A.; Mohamed, M. O.; Ibahim, S. Y.; Alkandari, F. A.; Bradley, D. A.

    2015-11-01

    Attaining high standards of efficiency and reliability in the practice of nuclear medicine requires appropriate quality control (QC) programs. For instance, the regular evaluation and comparison of extrinsic and intrinsic flood-field uniformity enables the quick correction of many gamma camera problems. Whereas QC tests for uniformity are usually performed by exposing the gamma camera crystal to a uniform flux of gamma radiation from a source of known activity, such protocols can vary significantly. Thus, there is a need for optimization and standardization, in part to allow direct comparison between gamma cameras from different vendors. In the present study, intrinsic uniformity was examined as a function of source distance, source activity, source volume and number of counts. The extrinsic uniformity and spatial resolution were also examined. Proper standard QC procedures need to be implemented because of the continual development of nuclear medicine imaging technology and the rapid expansion and increasing complexity of hybrid imaging system data. The present work seeks to promote a set of standard testing procedures to contribute to the delivery of safe and effective nuclear medicine services.

  11. Image quality testing of assembled IR camera modules

    NASA Astrophysics Data System (ADS)

    Winters, Daniel; Erichsen, Patrik

    2013-10-01

    Infrared (IR) camera modules for the LWIR (8-12_m) that combine IR imaging optics with microbolometer focal plane array (FPA) sensors with readout electronics are becoming more and more a mass market product. At the same time, steady improvements in sensor resolution in the higher priced markets raise the requirement for imaging performance of objectives and the proper alignment between objective and FPA. This puts pressure on camera manufacturers and system integrators to assess the image quality of finished camera modules in a cost-efficient and automated way for quality control or during end-of-line testing. In this paper we present recent development work done in the field of image quality testing of IR camera modules. This technology provides a wealth of additional information in contrast to the more traditional test methods like minimum resolvable temperature difference (MRTD) which give only a subjective overall test result. Parameters that can be measured are image quality via the modulation transfer function (MTF) for broadband or with various bandpass filters on- and off-axis and optical parameters like e.g. effective focal length (EFL) and distortion. If the camera module allows for refocusing the optics, additional parameters like best focus plane, image plane tilt, auto-focus quality, chief ray angle etc. can be characterized. Additionally, the homogeneity and response of the sensor with the optics can be characterized in order to calculate the appropriate tables for non-uniformity correction (NUC). The technology can also be used to control active alignment methods during mechanical assembly of optics to high resolution sensors. Other important points that are discussed are the flexibility of the technology to test IR modules with different form factors, electrical interfaces and last but not least the suitability for fully automated measurements in mass production.

  12. Statistical tests for prediction of lignite quality

    SciTech Connect

    C.J. Kolovos

    2007-06-15

    Domestic lignite from large, bucket wheel excavators based open pit mines is the main fuel for electricity generation in Greece. Lignite from one or more mines may arrive at any power plant stockyard. The mixture obtained constitutes the lignite fuel fed to the power plant. The fuel is sampled in regular time intervals. These samples are considered as results of observations of values of spatial random variables. The aim was to form and statistically test many small sample populations. Statistical tests on the values of the humidity content, the ash-water free content, and the lower heating value of the lignite fuel indicated that the sample values form a normal population. The Kolmogorov-Smirnov test was applied for testing goodness-of-fit of sample distribution for a three year period and different power plants of the Kozani-Ptolemais area, western Macedonia, Greece. The normal distribution hypothesis can be widely accepted for forecasting the distribution of values of the basic quality characteristics even for a small number of samples.

  13. Theoretical White Dwarf Spectra via the Internet: Quality Control

    NASA Astrophysics Data System (ADS)

    Ringat, E.; Reindl, N.

    2013-01-01

    The first decade of the Virtual Observatory (VO) built up services and tools for data conservation, handling, processing, analysis, etc. A new challenge in the immensely growing VO in operation is continuous quality control at different authority levels. Here we shed light on various aspects of theoretical white dwarf spectra that are provided via the registered TheoSSA VO service. We present benchmark tests that enable the VO user to judge their quality.

  14. Quality control of a teleradiology system

    NASA Astrophysics Data System (ADS)

    Lyche, David K.; Willis, Charles E.; Williamson, Morgan P.; Suitor, Charles T.; Romlein, John R.

    1996-04-01

    Teleradiology is being implemented in the U.S. military. Soft-copy reading of computed radiology (CR) images and film-digitizer (FD) images are becoming a common practice. The Medical Diagnostic Imaging Support (MDIS) Office at the Medical Advanced Technology Management Office (MATMO), Fort Detrick, Maryland, installed an 'off-the-shelf' DICOM teleradiology system by which CR images and FD images acquired at Hickam Air Force Base (AFB), Hawaii, are transmitted electronically over a T-1 telecommunications line to Tripler Army Medical Center (TAMC), Hawaii. The goal was to provide a diagnostic quality teleradiology system to the military services to extend the expertise and training of physicians to remote sites. In order to guarantee a diagnostic quality image throughout the system, a rigid set of quality control standards had to be designed and implemented. This poster presents the results of a successful teleradiology implementation where quality control is maintained throughout the imaging chain.

  15. Harmonisation Initiatives of Copernicus Data Quality Control

    NASA Astrophysics Data System (ADS)

    Vescovi, F. D.; Lankester, T.; Coleman, E.; Ottavianelli, G.

    2015-04-01

    The Copernicus Space Component Data Access system (CSCDA) incorporates data contributions from a wide range of satellite missions. Through EO data handling and distribution, CSCDA serves a set of Copernicus Services related to Land, Marine and Atmosphere Monitoring, Emergency Management and Security and Climate Change. The quality of the delivered EO products is the responsibility of each contributing mission, and the Copernicus data Quality Control (CQC) service supports and complements such data quality control activities. The mission of the CQC is to provide a service of quality assessment on the provided imagery, to support the investigation related to product quality anomalies, and to guarantee harmonisation and traceability of the quality information. In terms of product quality control, the CQC carries out analysis of representative sample products for each contributing mission as well as coordinating data quality investigation related to issues found or raised by Copernicus users. Results from the product analysis are systematically collected and the derived quality reports stored in a searchable database. The CQC service can be seen as a privileged focal point with unique comparison capacities over the data providers. The comparison among products from different missions suggests the need for a strong, common effort of harmonisation. Technical terms, definitions, metadata, file formats, processing levels, algorithms, cal/val procedures etc. are far from being homogeneous, and this may generate inconsistencies and confusion among users of EO data. The CSCDA CQC team plays a significant role in promoting harmonisation initiatives across the numerous contributing missions, so that a common effort can achieve optimal complementarity and compatibility among the EO data from multiple data providers. This effort is done in coordination with important initiatives already working towards these goals (e.g. INSPIRE directive, CEOS initiatives, OGC standards, QA4EO

  16. Protein quality control in the bacterial periplasm.

    PubMed

    Merdanovic, Melisa; Clausen, Tim; Kaiser, Markus; Huber, Robert; Ehrmann, Michael

    2011-01-01

    Protein quality control involves sensing and treatment of defective or incomplete protein structures. Misfolded or mislocalized proteins trigger dedicated signal transduction cascades that upregulate the production of protein quality-control factors. Corresponding proteases and chaperones either degrade or repair damaged proteins, thereby reducing the level of aggregation-prone molecules. Because the periplasm of gram-negative bacteria is particularly exposed to environmental changes and respective protein-folding stresses connected with the presence of detergents, low or high osmolarity of the medium, elevated temperatures, and the host's immune response, fine-tuned protein quality control systems are essential for survival under these unfavorable conditions. This review discusses recent advances in the identification and characterization of the key cellular factors and the emerging general principles of the underlying molecular mechanisms. PMID:21639788

  17. Post-translational Modification and Quality Control

    PubMed Central

    Wang, Xuejun; Pattison, J. Scott; Su, Huabo

    2013-01-01

    Protein quality control (PQC) functions to minimize the level and toxicity of misfolded proteins in the cell. PQC is performed by intricate collaboration among chaperones and target protein degradation. The latter is carried out primarily by the ubiquitin-proteasome system and perhaps autophagy. Terminally misfolded proteins that are not timely removed tend to form aggregates. Their clearance requires macroautophagy. Macroautophagy serves in intracellular quality control also by selectively segregating defective organelles (e.g., mitochondria) and targeting them for degradation by the lysosome. Inadequate PQC is observed in a large subset of failing human hearts with a variety of etiologies and its pathogenic role has been experimentally demonstrated. Multiple post-translational modifications (PTMs) can occur to substrate proteins and/or PQC machineries, promoting or hindering the removal of the misfolded proteins. This article highlights recent advances in PTMs-mediated regulation of intracellular quality control mechanisms and its known involvement in cardiac pathology. PMID:23329792

  18. Quality control in the secretory assembly line.

    PubMed Central

    Helenius, A

    2001-01-01

    As a rule, only proteins that have reached a native, folded and assembled structure are transported to their target organelles and compartments within the cell. In the secretory pathway of eukaryotic cells, this type of sorting is particularly important. A variety of molecular mechanisms are involved that distinguish between folded and unfolded proteins, modulate their intracellular transport, and induce degradation if they fail to fold. This phenomenon, called quality control, occurs at several levels and involves different types of folding sensors. The quality control system provides a stringent and versatile molecular sorting system that guaranties fidelity of protein expression in the secretory pathway. PMID:11260794

  19. Quality control and reliability of reported doses.

    PubMed

    Stadtmann, H; Figel, Markus; Kamenopoulou, V; Kluszczynski, D; Roed, H; Van Dijk, J

    2004-01-01

    Results of performance tests verifying the dosimetric properties of dosimetric systems are published in various reports (e.g. IAEA and EURADOS). However, there is hardly any information in the open literature relating to the uncertainty in a dose measurement or in the annual dose, which is increased by failure of the evaluation or data management system, damage of the dosemeter itself or by the loss of dosemeter. In this article, an attempt is made to estimate the importance of the above-mentioned conditions. This is achieved by sending questionnaires to about 200 approved dosimetric services in Europe. In total 88 questionnaires were returned and analysed. In the questionnaires, the frequency of occurrence of the various error conditions were investigated. Participants were also asked to evaluate the impact of the error condition from a dosimetric point of view and what countermeasures are taken. The article summarises all responses and compares different sources of errors according to their impact on the uncertainty of the resulting dose and gives a comprehensive overview on quality control actions and reliability on reported doses from European dosimetric services. PMID:15574990

  20. 30 CFR 28.31 - Quality control plans; contents.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 30 Mineral Resources 1 2014-07-01 2014-07-01 false Quality control plans; contents. 28.31 Section 28.31 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR TESTING, EVALUATION, AND APPROVAL OF MINING PRODUCTS FUSES FOR USE WITH DIRECT CURRENT IN PROVIDING SHORT-CIRCUIT PROTECTION FOR TRAILING CABLES IN COAL MINES...

  1. 30 CFR 28.30 - Quality control plans; filing requirements.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 30 Mineral Resources 1 2014-07-01 2014-07-01 false Quality control plans; filing requirements. 28.30 Section 28.30 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR TESTING, EVALUATION, AND APPROVAL OF MINING PRODUCTS FUSES FOR USE WITH DIRECT CURRENT IN PROVIDING...

  2. 30 CFR 28.30 - Quality control plans; filing requirements.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 30 Mineral Resources 1 2012-07-01 2012-07-01 false Quality control plans; filing requirements. 28.30 Section 28.30 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR TESTING, EVALUATION, AND APPROVAL OF MINING PRODUCTS FUSES FOR USE WITH DIRECT CURRENT IN PROVIDING...

  3. 30 CFR 28.30 - Quality control plans; filing requirements.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 30 Mineral Resources 1 2013-07-01 2013-07-01 false Quality control plans; filing requirements. 28.30 Section 28.30 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR TESTING, EVALUATION, AND APPROVAL OF MINING PRODUCTS FUSES FOR USE WITH DIRECT CURRENT IN PROVIDING...

  4. Quality control of leather by terahertz time-domain spectroscopy.

    PubMed

    Hernandez-Serrano, A I; Corzo-Garcia, S C; Garcia-Sanchez, E; Alfaro, M; Castro-Camus, E

    2014-11-20

    We use terahertz time-domain spectroscopy, combined with effective-medium theory, to measure the moisture content and thickness of leather simultaneously. These results demonstrate that this method could become a standard quality control test for the industrial tanning process. PMID:25607861

  5. HANDBOOK FOR ANALYTICAL QUALITY CONTROL IN WATER AND WASTEWATER LABORATORIES

    EPA Science Inventory

    This handbook is addressed to laboratory directors, leaders of field investigations, and other personnel who bear responsibility for water and wastewater data. Subject matter of the handbook is concerned primarily with quality control (QC) for chemical and biological tests and me...

  6. Protein Quality Control and Metabolism: Bidirectional Control in the Heart

    PubMed Central

    Wang, Zhao V.; Hill, Joseph A.

    2015-01-01

    The prevalence of heart disease, especially heart failure, continues to increase, and cardiovascular disease remains the leading cause of death worldwide. As cardiomyocytes are essentially irreplaceable, protein quality control is pivotal to cellular homeostasis and, ultimately, cardiac performance. Three evolutionarily conserved mechanisms – autophagy, the unfolded protein response, and the ubiquitin-proteasome system– act in concert to degrade misfolded proteins and eliminate defective organelles. Recent advances have revealed that these mechanisms are intimately associated with cellular metabolism. Going forward, comprehensive understanding of the role of protein quality control mechanisms in cardiac pathology will require integration of metabolic pathways and metabolic control. PMID:25651176

  7. [Quality control of Maca (Lepidium meyenii)].

    PubMed

    Shu, Ji-cheng; Cui, Hang-qing; Huang, Ying-zheng; Huang, Xiao-ying; Yang, Ming

    2015-12-01

    To control the quality of Maca, the quality standard was established in this study. According to the methods recorded in the Appendix of Chinese Pharmacopoeia (2010 Edition), the water, extract, total ash, acid insoluble substance, and heavy metals inspections in Lepidium meyenii were carried out. N-benzyl-9Z, 12Z-octadecadienamide in L. meyenii was identified by TLC, and it was determined by HPLC. The results showed that the N-benzyl-9Z, 12Z-octadecadienamide identification of TLC was a strong mark and specificity. In content determination experiment, the linearity of N-benzyl-9Z, 12Z-octadecadienamide was in the range of 0.01-2 microg (r = 0.9998), and the average recovery (n=9) was 99.27% (RSD 2.0%). The methods were simple, accurate, with good reproducibility. It is suitable for quality control L. meyenii. PMID:27141660

  8. Outsourcing University Degrees: Implications for Quality Control

    ERIC Educational Resources Information Center

    Edwards, Julie; Crosling, Glenda; Edwards, Ron

    2010-01-01

    Education institutions worldwide have and continue to seek opportunities to spread their offerings abroad. While the provision of courses to students located overseas through partner institutions has many advantages, it raises questions about quality control that are not as applicable to other forms of international education. This paper uses a…

  9. 33 CFR 385.21 - Quality control.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... will be produced by a Project Delivery Team. The quality control plan shall be included in the Project Management Plan and shall describe the procedures to be used to ensure compliance with technical and policy requirements during implementation. (b) During development of the Project Management Plan for each project,...

  10. 33 CFR 385.21 - Quality control.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... will be produced by a Project Delivery Team. The quality control plan shall be included in the Project Management Plan and shall describe the procedures to be used to ensure compliance with technical and policy requirements during implementation. (b) During development of the Project Management Plan for each project,...

  11. 33 CFR 385.21 - Quality control.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... will be produced by a Project Delivery Team. The quality control plan shall be included in the Project Management Plan and shall describe the procedures to be used to ensure compliance with technical and policy requirements during implementation. (b) During development of the Project Management Plan for each project,...

  12. Acoustic resonance techniques for quality control

    SciTech Connect

    Sinha, D.N.

    1992-09-01

    Acoustic resonance based nondestructive techniques are described that can be used for both process and quality control in manufacturing. The Acoustic Resonance Spectroscopy (AS) technique is highlighted for its capability in fluid property (flow, density, viscosity, and speed of sound) monitoring. Possible applications of these noninvasive techniques for textile manufacturing are pointed out.

  13. Acoustic resonance techniques for quality control

    SciTech Connect

    Sinha, D.N.

    1992-01-01

    Acoustic resonance based nondestructive techniques are described that can be used for both process and quality control in manufacturing. The Acoustic Resonance Spectroscopy (AS) technique is highlighted for its capability in fluid property (flow, density, viscosity, and speed of sound) monitoring. Possible applications of these noninvasive techniques for textile manufacturing are pointed out.

  14. Experience in the quality-assurance testing of HEPA filters

    SciTech Connect

    Burchsted, C.A.

    1982-01-01

    The DOE HEPA filter quality-assurance test program was initiated in 1960 to ensure the supply of adequate filters for environmental control applications in DOE operations. The program has played a significant role in the development and improvement of HEPA filters, and has more than paid for itself. However, the receipt of large numbers of filters which require repair or waiver of specification requirements, even as recent as 1980 and 1981, indicates that there are problems in the HEPA filter manufacturing industry. It is clear that DOE users are receiving the cream of the crop of HEPA filters, but that other users who do not avail themselves of the DOE testing service are receiving filters of lesser quality.

  15. Development of methodology and technology for identifying and quantifying emission products from open-burning and open-detonation thermal-treatment methods. Field Test Series A, B, and C. Volume 2, Part B. Quality assurance and quality control. Appendices. Final report, Dec 88-Jan 92

    SciTech Connect

    Johnson, M.

    1992-01-01

    The report describes the quality assurance/quality control program conducted during 1990 field testing which supported the OB/OD Thermal Treatment Methods Study. The QA/QC program encompassed sample collection, preparation, storage, extraction, analytical instrument operation, data reduction, statistical data analyses and interpretation. Samples included atmosphere collected in evacuated stainless steel canisters, soil, and Teflon coated-glass-fiber media. The supercritical fluid chromatograph and gas chromatograph with mass spectrometers were the principal laboratory analytical instruments used during these field tests. Real-time instruments detected and quantified CO, CO2, NO, NO2, and NOx. Near-real-time analyses were accomplished by use of a Teflon bag in which samples of the plume were collected for analyses during testing operations. Sample-tracking was conducted using a system which permitted precise identification of individual specimens from collection through analyses or archiving. Analysis of atmosphere and soil samples spiked by the U.S. Environmental Protection Agency (EPA) reflected a degree of accuracy well within acceptable limits. Open burning; open detonation; OB/OD; TNT; double base propellant; manufacturers residue propellant; air emissions; thermal treatment; carbon balance; emission factor; supercritical fluid chromatography; SFC; demilitarization; munition dispersal; explosive dispersal; environment; BB; air building; U.S. Environmental Protection Agency; EPA; quality assurance; OA; quality control; QC; RDX; composition B; explosive D; Ml propellant; and M6 propellant.

  16. Real-time quality control: the French Minitel system.

    PubMed

    Goguel, A; LeBlanc, A

    1990-01-01

    A prototype system designed to provide real-time response to inter-laboratory proficiency testing results has been developed using the French Minitel telecommunication system. This nationwide computer networking system allows for instantaneous reporting and evaluation of results obtained on external quality assessment (EQA) samples. If a certain test is in error and presumably out of control the problem can be remedied immediately with obvious advantages to patient care. PMID:2282753

  17. Designing in quality through design control: a manufacturer's perspective.

    PubMed

    Lasky, F D; Boser, R B

    1997-05-01

    Quality by design is a comprehensive program that begins with understanding user needs and continues through (but does not end with) monitoring customer acceptance. Management tools and processes such as ISO 9000 standards and the Food and Drug Administration Quality System Regulations exist to guide medical device manufacturers in quality practices. The goal is to deliver products acceptable for their intended use. Quality control begins with defining attributes ranging from color to accuracy and precision. Failure mode and effects analysis and risk analysis consider both probability and severity of potential malfunctions and their effects on patients or operators. Tools used to implement design and production practices include Program Evaluation and Review Technique (PERT) charts and industry-conceived concepts, such as Six Sigma techniques. Their use varies with manufacturer, depending on product and customer needs and the manufacturer's specific quality practices. Verification confirms that input goals are met. Then, validation assures that intended clinical needs are continually satisfied by establishing adequate production specifications. Conformance is monitored to verify that stable, consistent processes are in place, and precise user instructions enable the device to satisfy its intended use. Finally, complaint tracking can help assess whether needs have been met. Modifications in service, hardware, or instructions (including quality control) might be required. Therefore, both manufacturers and users work in partnership for continual improvement. The manufacturer's knowledge of design, production, and service needs of its devices enable it to recommend appropriate quality-control protocols for clinical testing. PMID:9166255

  18. Computer controlled thermal fatigue test system

    SciTech Connect

    Schmale, D.T.; Jones, W.B.

    1986-01-01

    A servo-controlled hydraulic mechanical test system has been configured to conduct computer-controlled thermal fatigue tests. The system uses induction heating, a digital temperature controller, infrared pyrometry, forced air cooling, and quartz rod extensometry. In addition, a digital computer controls the tests and allows precise data analysis and interpretation.

  19. 42 CFR 84.40 - Quality control plans; filing requirements.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 1 2010-10-01 2010-10-01 false Quality control plans; filing requirements. 84.40... Control § 84.40 Quality control plans; filing requirements. As a part of each application for approval or... proposed quality control plan which shall be designed to assure the quality of respiratory...

  20. 30 CFR 28.30 - Quality control plans; filing requirements.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Quality control plans; filing requirements. 28... PROTECTION FOR TRAILING CABLES IN COAL MINES Quality Control § 28.30 Quality control plans; filing... part, each applicant shall file with MSHA a proposed quality control plan which shall be designed...

  1. 21 CFR 211.22 - Responsibilities of quality control unit.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 4 2010-04-01 2010-04-01 false Responsibilities of quality control unit. 211.22... Personnel § 211.22 Responsibilities of quality control unit. (a) There shall be a quality control unit that... have been fully investigated. The quality control unit shall be responsible for approving or...

  2. 30 CFR 28.30 - Quality control plans; filing requirements.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 30 Mineral Resources 1 2011-07-01 2011-07-01 false Quality control plans; filing requirements. 28... PROTECTION FOR TRAILING CABLES IN COAL MINES Quality Control § 28.30 Quality control plans; filing... part, each applicant shall file with MSHA a proposed quality control plan which shall be designed...

  3. 42 CFR 84.40 - Quality control plans; filing requirements.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 1 2011-10-01 2011-10-01 false Quality control plans; filing requirements. 84.40... Control § 84.40 Quality control plans; filing requirements. As a part of each application for approval or... proposed quality control plan which shall be designed to assure the quality of respiratory...

  4. Can external quality control improve pig AI efficiency?

    PubMed

    Waberski, D; Petrunkina, A M; Töpfer-Petersen, E

    2008-11-01

    External quality control programmes carried out by central laboratories have been long established in human andrology with the aim of enhancing the accuracy and reproducibility of semen assessment. Compared to human, demands on boar semen assessment in AI stations are more complex, with the need both to identify boars with poor ejaculate quality and to monitor individual boar differences for semen storage. Additionally, appropriate assessment serves as a control instrument to ensure the security and efficiency of semen processing. Despite current limitations regarding the ability of sperm assays to estimate the potential fertility of males, it is evident that boar fertility is related to certain conventional semen tests, e.g. sperm morphology. In central studies carried out on stored semen from 11 AI stations, flow cytometric assessment of plasma and acrosome membrane integrity proved to be more sensitive in detecting sperm damage associated with ageing and temperature stress as compared to light microscopy. Membrane integrity of stored semen differed between AI stations indicating significant influences of semen processing on sperm quality. Thus external control of semen quality in reference laboratories may be useful to monitor the efficiency of internal semen quality control in individual AI stations, to identify males with lower semen quality and/or poor response to semen storage, and to verify the precision of sperm counting. The possibility that central laboratories with sufficient resources may be able to identify functionally different responding sperm subpopulations for better estimation of fertility is discussed. Ideally, external quality control schemes for AI stations would comprise application of validated tests with high relevance for fertility (including bacterial status), analysis of semen processing on the AI station, and training courses for laboratory personnel. PMID:18656253

  5. Practicing Quality Control in a Bioanalytical Experiment

    NASA Astrophysics Data System (ADS)

    Marcos, Juliana; Ríos, Angel; Valcárcel, Miguel

    1995-10-01

    The quality of analytical results frequently requires assessment, which has fostered treatment of this subject in a host of chemical books for students. Accordingly, new experiments need to be devised in order to help students adapt to it. This paper presents a straightforward exercise to demonstrate how quality control and the analysis of variance technique are implemented in practice. The exercise also is attractive because the analyte (chlorophyl) is determined in real samples (plants) that students can collect by themselves. In this way, they can realize the significance of sampling and learn how to do it properly.

  6. Quality and Control of Water Vapor Winds

    NASA Technical Reports Server (NTRS)

    Jedlovec, Gary J.; Atkinson, Robert J.

    1996-01-01

    Water vapor imagery from the geostationary satellites such as GOES, Meteosat, and GMS provides synoptic views of dynamical events on a continual basis. Because the imagery represents a non-linear combination of mid- and upper-tropospheric thermodynamic parameters (three-dimensional variations in temperature and humidity), video loops of these image products provide enlightening views of regional flow fields, the movement of tropical and extratropical storm systems, the transfer of moisture between hemispheres and from the tropics to the mid- latitudes, and the dominance of high pressure systems over particular regions of the Earth. Despite the obvious larger scale features, the water vapor imagery contains significant image variability down to the single 8 km GOES pixel. These features can be quantitatively identified and tracked from one time to the next using various image processing techniques. Merrill et al. (1991), Hayden and Schmidt (1992), and Laurent (1993) have documented the operational procedures and capabilities of NOAA and ESOC to produce cloud and water vapor winds. These techniques employ standard correlation and template matching approaches to wind tracking and use qualitative and quantitative procedures to eliminate bad wind vectors from the wind data set. Techniques have also been developed to improve the quality of the operational winds though robust editing procedures (Hayden and Veldon 1991). These quality and control approaches have limitations, are often subjective, and constrain wind variability to be consistent with model derived wind fields. This paper describes research focused on the refinement of objective quality and control parameters for water vapor wind vector data sets. New quality and control measures are developed and employed to provide a more robust wind data set for climate analysis, data assimilation studies, as well as operational weather forecasting. The parameters are applicable to cloud-tracked winds as well with minor

  7. [Study thought of pharmaceutical preparations quality standards by dynamic quality control technology].

    PubMed

    Yu, Dan-Hong; Mao, Chen-Mei; Lv, Cheng-Zhe; Jin, Hui-Zhen; Yao, Xin; Jia, Xiao-Bin

    2014-07-01

    Pharmaceutical preparations, particularly as a "secret recipe" of traditional Chinese medicine in medical institutions, are the product of China's medical and health industry, and they are also an important means of competing of different medical institutions. Although pharmaceutical preparations have advantages and characteristics than institutes for drug and pharmaceutical companies, the quality standards of pharmaceutical preparations in medical institutions has not reached the desired level over the years. As we all know, the quality of pharmaceutical preparations is important to ensure the efficacy, especially under the environment of people pay more sttention on drug safety and effectiveness and contry increase emphasis on the stste of pharmaceutical preparations. In view of this, we will improve the grade, stability, and clinical efficacy of pharmaceutical preparations by the advanced equipment, testing instruments and the process dynamic quality control technology. Finally, we hope we can provide new ideas for the quality control of pharmaceutical preparations. PMID:25272516

  8. Manufacture and quality control of interconnecting wire hardnesses, Volume 1

    NASA Technical Reports Server (NTRS)

    1972-01-01

    A standard is presented for manufacture, installation, and quality control of eight types of interconnecting wire harnesses. The processes, process controls, and inspection and test requirements reflected are based on acknowledgment of harness design requirements, acknowledgment of harness installation requirements, identification of the various parts, materials, etc., utilized in harness manufacture, and formulation of a typical manufacturing flow diagram for identification of each manufacturing and quality control process, operation, inspection, and test. The document covers interconnecting wire harnesses defined in the design standard, including type 1, enclosed in fluorocarbon elastomer convolute, tubing; type 2, enclosed in TFE convolute tubing lines with fiberglass braid; type 3, enclosed in TFE convolute tubing; and type 5, combination of types 3 and 4. Knowledge gained through experience on the Saturn 5 program coupled with recent advances in techniques, materials, and processes was incorporated.

  9. Quality Control of Trichinella Testing at the Slaughterhouse Laboratory: Evaluation of the Use of a 400-Micrometer-Mesh-Size Sieve in the Magnetic Stirrer Method.

    PubMed

    Franssen, Frits; van Andel, Esther; Swart, Arno; van der Giessen, Joke

    2016-02-01

    The performance of a 400-μm-mesh-size sieve (sieve400) has not previously been compared with that of a 180-μm-mesh-size sieve (sieve180). Using pork samples spiked with 0 to 10 Trichinella muscle larvae and an artificial digestion method, sieve performance was evaluated for control of Trichinella in meat-producing animals. The use of a sieve400 resulted in 12% lower larval counts, 147% more debris, and 28% longer counting times compared with the use of a sieve180. Although no false-negative results were obtained, prolonged counting times with the sieve400 may have an impact on performance in a high-throughput environment such as a slaughterhouse laboratory. Based on our results, the sieve180 remains the sieve of choice for Trichinella control in meat in slaughterhouse laboratories, according to the European Union reference method (European Commission regulation 2075/2005). Furthermore, the results of the present study contribute to the discussion of harmonization of meat inspection requirements among countries. PMID:26818995

  10. Protein quality control in the nucleus.

    PubMed

    Jones, Ramon D; Gardner, Richard G

    2016-06-01

    The nucleus is the repository for the eukaryotic cell's genetic blueprint, which must be protected from harm to ensure survival. Multiple quality control (QC) pathways operate in the nucleus to maintain the integrity of the DNA, the fidelity of the DNA code during replication, its transcription into mRNA, and the functional structure of the proteins that are required for DNA maintenance, mRNA transcription, and other important nuclear processes. Although we understand a great deal about DNA and RNA QC mechanisms, we know far less about nuclear protein quality control (PQC) mechanisms despite that fact that many human diseases are causally linked to protein misfolding in the nucleus. In this review, we discuss what is known about nuclear PQC and we highlight new questions that have emerged from recent developments in nuclear PQC studies. PMID:27015023

  11. Quality control analytical methods: strategies to ensure a robust quality-control microbiology program.

    PubMed

    Griffiths, Tricia; Connors, Anne

    2013-01-01

    As the regulatory environment for compounding pharmacies continues to evolve, facilities can take immediate steps to strengthen their quality-control microbiology and environmental monitoring programs. Robust programs that are timely, comprehensive, and effective will minimize risk and help support positive patient outcomes. This article provides a roadmap for putting in place a robust quality-control microbiology program in the face of United States Pharmacopeia Chapter 797 standards, and highlights several technologies for environmental monitoring that support a successful program. PMID:23696174

  12. Towards quality control of food using terahertz

    NASA Astrophysics Data System (ADS)

    Ung, B. S.-Y.; Fischer, B. M.; Ng, B. W.-H.; Abbott, D.

    2007-12-01

    Terahertz radiation or T-rays, show promise in quality control of food products. As T-rays are inherently sensitive to water, they are very suitable for moisture detection. This proves to be a valuable asset in detecting the moisture content of dried food, a critical area for some products. As T-rays are transparent to plastics, food additives can also be probed through the packaging, providing checks against a manufacturer's claims, such as the presence of certain substances in foods.

  13. Germination tests for assessing biochar quality

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Understanding the impact of biochar quality on soil productivity is crucial to the agronomic acceptance of biochar amendments. Our objective in this study was to develop a quick and reliable screening procedures to characterize the quality of biochar amendments. Biochars were evaluated by both seed ...

  14. Reinventing Teaching and Testing: Quality Learning for Quality Employment.

    ERIC Educational Resources Information Center

    Cooke, Brian P.

    To succeed in today's competitive global markets, organizations are hiring responsible problem solvers and collaborative "associates" who improve productivity, assure quality service, and contribute creatively. These organizations demand employees who are skilled at learning to learn, listening, communicating, problem solving, teamwork, and…

  15. Process and quality verification controls for solid propellant manufacturing

    NASA Technical Reports Server (NTRS)

    Rogers, C. J.

    1983-01-01

    It is pointed out that in-process tests to verify quality and detect discrepant propellant which could compromise motor performance are essential elements of the solid composite propellant manufacturing process. The successful performance of the 260SL-1 and 260SL-2 motors aptly verified the controls used for manufacturing the propellant. The present investigation is concerned with the selected control parameters, and their relationships to composition and final propellant properties. Control performance is evaluated by comparison with processing data experienced in the manufacture of the propellant for the 260SL-1 motor. It is found that the in-process quality verification controls utilized in the propellant manufacturing process for the 260-in. diameter motor contributed significantly to the confidence of successful and predictable motor performance.

  16. Cool-Water Coal Gasification Program: Environmental Monitoring Plan Commissioning Phase, final report. Volume 1. Technical report. Volume 2. Appendix A - HRSG (heat recovery steam generator) stack-testing results. Volume 3. Appendix B - analytical results. Appendix C - sampling analytical methods. Appendix D - ambient air monitoring data. Volume 4. Appendix E - quality assurance/quality control. Technical report

    SciTech Connect

    Not Available

    1985-10-11

    The Cool Water Coal Gasification Program (CWCGP) began electrical production under the terms of the Price Guarantee Commitment with the U.S. Synthetic Fuels Corporation (SFC) on June 24, 1984. An Environmental Monitoring Plan (EMP) approved by the SFC was initiated at that time. The Commissioning Phase, the first of four phases of the EMP, was conducted from June 24 through December 31, 1984. Sampling and analysis of compliance and supplemental parameters produced over 1100 samples and 8500 data points from 17 aqueous, ten gaseous, and four solid sampling streams. The technical report includes a description of the CWCGP process as it was operated during the Commissioning Phase, a summary of process changes that occurred during the period, their effect on the environmental monitoring effort, and details of pollution-control testing (Appendix A), data calculations (Appendix B), analytical methods and results (Appendix C), ambient-air-monitoring data (Appendix D), and quality-assurance/quality-control program results (Appendix E).

  17. Naturalness and interestingness of test images for visual quality evaluation

    NASA Astrophysics Data System (ADS)

    Halonen, Raisa; Westman, Stina; Oittinen, Pirkko

    2011-01-01

    Balanced and representative test images are needed to study perceived visual quality in various application domains. This study investigates naturalness and interestingness as image quality attributes in the context of test images. Taking a top-down approach we aim to find the dimensions which constitute naturalness and interestingness in test images and the relationship between these high-level quality attributes. We compare existing collections of test images (e.g. Sony sRGB images, ISO 12640 images, Kodak images, Nokia images and test images developed within our group) in an experiment combining quality sorting and structured interviews. Based on the data gathered we analyze the viewer-supplied criteria for naturalness and interestingness across image types, quality levels and judges. This study advances our understanding of subjective image quality criteria and enables the validation of current test images, furthering their development.

  18. A fast and simple dose-calibrator-based quality control test for the radionuclidic purity of cyclotron-produced 99mTc

    NASA Astrophysics Data System (ADS)

    Tanguay, J.; Hou, X.; Esquinas, P.; Vuckovic, M.; Buckley, K.; Schaffer, P.; Bénard, F.; Ruth, T. J.; Celler, A.

    2015-11-01

    Cyclotron production of {{}99\\text{m}} Tc through the 100Mo(p,2n){{}99\\text{m}} Tc reaction channel is actively being investigated as an alternative to reactor-based 99Mo generation by nuclear fission of 235U. Like most radioisotope production methods, cyclotron production of {{}99\\text{m}} Tc will result in creation of unwanted impurities, including Tc and non-Tc isotopes. It is important to measure the amounts of these impurities for release of cyclotron-produced {{}99\\text{m}} Tc (CPTc) for clinical use. Detection of radioactive impurities will rely on measurements of their gamma (γ) emissions. Gamma spectroscopy is not suitable for this purpose because the overwhelming presence of {{}99\\text{m}} Tc and the count-rate limitations of γ spectroscopy systems preclude fast and accurate measurement of small amounts of impurities. In this article we describe a simple and fast method for measuring γ emission rates from radioactive impurities in CPTc. The proposed method is similar to that used to identify 99Mo breakthrough in generator-produced {{}99\\text{m}} Tc: one dose calibrator (DC) reading of a CPTc source placed in a lead shield is followed by a second reading of the same source in air. Our experimental and theoretical analysis show that the ratio of DC readings in lead to those in air are linearly related to γ emission rates from impurities per MBq of {{}99\\text{m}} Tc over a large range of clinically-relevant production conditions. We show that estimates of the γ emission rates from Tc impurities per MBq of {{}99\\text{m}} Tc can be used to estimate increases in radiation dose (relative to pure {{}99\\text{m}} Tc) to patients injected with CPTc-based radiopharmaceuticals. This enables establishing dosimetry-based clinical-release criteria that can be tested using commercially-available dose calibrators. We show that our approach is highly sensitive to the presence of {{}93\\text{g}} Tc, {{}93\\text{m}} Tc, {{}94\\text{g}} Tc, {{}94\\text{m}} Tc

  19. A fast and simple dose-calibrator-based quality control test for the radionuclidic purity of cyclotron-produced (99m)Tc.

    PubMed

    Tanguay, J; Hou, X; Esquinas, P; Vuckovic, M; Buckley, K; Schaffer, P; Bénard, F; Ruth, T J; Celler, A

    2015-11-01

    Cyclotron production of 99mTc through the (100)Mo(p,2n)99mTc reaction channel is actively being investigated as an alternative to reactor-based (99)Mo generation by nuclear fission of (235)U. Like most radioisotope production methods, cyclotron production of 99mTc will result in creation of unwanted impurities, including Tc and non-Tc isotopes. It is important to measure the amounts of these impurities for release of cyclotron-produced 99mTc (CPTc) for clinical use. Detection of radioactive impurities will rely on measurements of their gamma (γ) emissions. Gamma spectroscopy is not suitable for this purpose because the overwhelming presence of 99mTc and the count-rate limitations of γ spectroscopy systems preclude fast and accurate measurement of small amounts of impurities. In this article we describe a simple and fast method for measuring γ emission rates from radioactive impurities in CPTc. The proposed method is similar to that used to identify (99)Mo breakthrough in generator-produced 99mTc: one dose calibrator (DC) reading of a CPTc source placed in a lead shield is followed by a second reading of the same source in air. Our experimental and theoretical analysis show that the ratio of DC readings in lead to those in air are linearly related to γ emission rates from impurities per MBq of 99mTc over a large range of clinically-relevant production conditions. We show that estimates of the γ emission rates from Tc impurities per MBq of 99mTc can be used to estimate increases in radiation dose (relative to pure 99mTc) to patients injected with CPTc-based radiopharmaceuticals. This enables establishing dosimetry-based clinical-release criteria that can be tested using commercially-available dose calibrators. We show that our approach is highly sensitive to the presence of 93gTc, 93mTc, 94gTc, 94mTc, 95mTc, 95gTc, and 96gTc, in addition to a number of non-Tc impurities. PMID:26449791

  20. 10 CFR 71.123 - Test control.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 2 2011-01-01 2011-01-01 false Test control. 71.123 Section 71.123 Energy NUCLEAR....123 Test control. The licensee, certificate holder, and applicant for a CoC shall establish a test... satisfactorily in service is identified and performed in accordance with written test procedures that...

  1. 10 CFR 72.162 - Test control.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 2 2011-01-01 2011-01-01 false Test control. 72.162 Section 72.162 Energy NUCLEAR... Test control. The licensee, applicant for a license, certificate holder, and applicant for a CoC shall establish a test program to ensure that all testing, required to demonstrate that the structures,...

  2. Controlled Hover Test No. 4

    NASA Video Gallery

    NASA's Robotic Lander Development Project at Marshall Space Flight Center in Huntsville, Ala. conducts the second free-flight test of a robotic lander prototype. During test the lander successfully...

  3. Cursor Control Device Test Battery

    NASA Technical Reports Server (NTRS)

    Holden, Kritina; Sandor, Aniko; Pace, John; Thompson, Shelby

    2013-01-01

    The test battery was developed to provide a standard procedure for cursor control device evaluation. The software was built in Visual Basic and consists of nine tasks and a main menu that integrates the set-up of the tasks. The tasks can be used individually, or in a series defined in the main menu. Task 1, the Unidirectional Pointing Task, tests the speed and accuracy of clicking on targets. Two rectangles with an adjustable width and adjustable center- to-center distance are presented. The task is to click back and forth between the two rectangles. Clicks outside of the rectangles are recorded as errors. Task 2, Multidirectional Pointing Task, measures speed and accuracy of clicking on targets approached from different angles. Twenty-five numbered squares of adjustable width are arranged around an adjustable diameter circle. The task is to point and click on the numbered squares (placed on opposite sides of the circle) in consecutive order. Clicks outside of the squares are recorded as errors. Task 3, Unidirectional (horizontal) Dragging Task, is similar to dragging a file into a folder on a computer desktop. Task 3 requires dragging a square of adjustable width from one rectangle and dropping it into another. The width of each rectangle is adjustable, as well as the distance between the two rectangles. Dropping the square outside of the rectangles is recorded as an error. Task 4, Unidirectional Path Following, is similar to Task 3. The task is to drag a square through a tunnel consisting of two lines. The size of the square and the width of the tunnel are adjustable. If the square touches any of the lines, it is counted as an error and the task is restarted. Task 5, Text Selection, involves clicking on a Start button, and then moving directly to the underlined portion of the displayed text and highlighting it. The pointing distance to the text is adjustable, as well as the to-be-selected font size and the underlined character length. If the selection does not

  4. 21 CFR 111.117 - What quality control operations are required for equipment, instruments, and controls?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... and Process Control System: Requirements for Quality Control § 111.117 What quality control operations are required for equipment, instruments, and controls? Quality control operations for equipment... 21 Food and Drugs 2 2011-04-01 2011-04-01 false What quality control operations are required...

  5. 21 CFR 111.117 - What quality control operations are required for equipment, instruments, and controls?

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 21 Food and Drugs 2 2013-04-01 2013-04-01 false What quality control operations are required for... and Process Control System: Requirements for Quality Control § 111.117 What quality control operations are required for equipment, instruments, and controls? Quality control operations for...

  6. 21 CFR 111.117 - What quality control operations are required for equipment, instruments, and controls?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 21 Food and Drugs 2 2014-04-01 2014-04-01 false What quality control operations are required for... and Process Control System: Requirements for Quality Control § 111.117 What quality control operations are required for equipment, instruments, and controls? Quality control operations for...

  7. Possible approaches to fast quality control of IFE targets

    NASA Astrophysics Data System (ADS)

    Koresheva, E. R.; Nikitenko, A. I.; Aleksandrova, I. V.; Bazdenkov, S. V.; Belolipetskiy, A. A.; Chtcherbakov, V. I.; Osipov, I. E.

    2006-11-01

    In recent years, research into the development of reliable methods and techniques for characterization and quality control of ICF/IFE targets has been carried out very actively. This is motivated by the need to provide the means for precise and accurate knowledge of cryogenic target parameters. On the other hand, particular emphasis should be paid to the fact that fuelling of a commercial power plant requires ~6 targets each second. This indicates that the development of fast quality control techniques is of critical importance as well. Therefore, in this report we discuss the issues underlying the construction of different algorithms for characterization and quality control of ICF/IFE targets. Among them are: (a) algorithm banks and their structure, (b) algorithm testing, (c) target reconstruction experiments. The algorithm bank incorporates the algorithms for two stages of target production: the stage of fuel layering technique development (motionless target) and the stage of cryogenic target delivery (injected target). In the first case an inverse algorithm for individual target characterization (3D target reconstruction) and two threshold algorithms for fast control of target quality are presented. They are based on tomographic information processing methods. Experimentally, tomographic data acquisition is carried out by a hundred projections microtomograph. The spatial resolution of the optical system of the microtomograph is 1 µm for 490 nm wavelength, the accuracy of target angular positioning is ±1.5-2.5 min. In the second case we describe the algorithm based on Fourier transform holography for ultra fast target characterization during its injection. The performed computer experiments have demonstrated much promise of this approach in the following directions: recognition of the target imperfections in both low- and high- harmonics; quality control of both a single target and a target batch; simultaneous control of both an injected target quality and its

  8. Quality control in the year 2000

    PubMed Central

    Schade, Bernd

    1992-01-01

    ‘Just-in-time’ production is a prerequisite for a company to meet the challenges of competition. Manufacturing cycles have been so successfully optimized that release time now has become a significant factor. A vision for a major quality-control (QC) contribution to profitability in this decade seems to be the just-in-time release. Benefits will go beyond cost savings for lower inventory. The earlier detection of problems will reduce rejections and scrap. In addition, problem analysis and problem-solving will be easier. To achieve just-in-time release, advanced automated systems like robots will become the workhorses in QC for high volume pharmaceutical production. The requirements for these systems are extremely high in terms of quality, reliability and ruggedness. Crucial for the success might be advances in use of microelectronics for error checks, system recording, trouble shooting, etc. as well as creative new approaches (for example the use of redundant assay systems). PMID:18924930

  9. Quality control in the year 2000.

    PubMed

    Schade, B

    1992-01-01

    'Just-in-time' production is a prerequisite for a company to meet the challenges of competition. Manufacturing cycles have been so successfully optimized that release time now has become a significant factor. A vision for a major quality-control (QC) contribution to profitability in this decade seems to be the just-in-time release. Benefits will go beyond cost savings for lower inventory. The earlier detection of problems will reduce rejections and scrap. In addition, problem analysis and problem-solving will be easier. To achieve just-in-time release, advanced automated systems like robots will become the workhorses in QC for high volume pharmaceutical production. The requirements for these systems are extremely high in terms of quality, reliability and ruggedness. Crucial for the success might be advances in use of microelectronics for error checks, system recording, trouble shooting, etc. as well as creative new approaches (for example the use of redundant assay systems). PMID:18924930

  10. Mammographic equipment, technique, and quality control

    SciTech Connect

    Friedrich, M.A. )

    1991-08-01

    The most important improvements in mammographic technique were the introduction of single- or double-emulsion high-contrast film-screen combinations for mammography, the use of a specially designed low-kilovoltage Bucky grid to reduce scattered radiation, and the introduction of smaller focal spots to improve imaging geometry. Magnification techniques, especially the spot-film technique, yields clearer delineation of high-contrast microcalcifications. Dedicated mammographic equipment with specially designed x-ray tubes is necessary for modern high-quality mammography. However, in many modern mammographic units, the automatic exposure controller still fails to provide appropriate and constant optical film density over a wide range of tissue thickness and absorption. Extended-cycle processing of single-emulsion mammographic films can yield better image contrast and reduce exposure by up to 30%. Exposure times of less than 1 second are recommended to avoid the unnecessary higher doses caused by longer exposure times and reciprocity law failure. The wide dynamic range in mammography can be reduced by a beam equalization filter, and thus be better adapted to the decreased latitude of modern high-contrast mammographic screen-film systems. Mammographic film reading (detection of subtle microcalcifications) can be facilitated by modern computer evaluation of previously digitized mammograms. Standardization and assurance of image quality have been major challenges in the technical development of mammography. Different technical and anthropomorphic phantoms have been designed to measure and compare practical image quality. Detailed quality control measures have been developed. The benefit of a single or annual screening mammography, calculated in gained life expectancy, by far outweighs the relative risk for radiation-induced breast cancer. 22 references.

  11. Intercity rail-passenger car ride quality test program

    NASA Technical Reports Server (NTRS)

    Scharr, R. L.; Owings, R. P.

    1975-01-01

    The Federal Railroad Administration's research and development program relating to intercity rail-passenger ride quality focuses on developing ride quality design criteria and specifications. The FRA ride quality test program and some of the techniques being used to analyze and evaluate the design criteria of the program are discussed.

  12. Soil moisture and strength index for earthwork construction quality control

    NASA Astrophysics Data System (ADS)

    Sawangsuriya, A.; Wachiraporn, S.; Sramoon, W.

    2015-09-01

    This paper presents the implementation of soil moisture and strength index measurements for earthwork construction quality control as well as a link between the in situ testing and structural property of earthen materials. Use of the convenient Dynamic Cone Penetrometer (DCP) in conjunction with conventional moisture-density measurements enhances quality control by achieving acceptable level of compaction, more uniform structural properties, and aids developing a controlled design parameter during the earthwork construction. Soil strength in term of DCP index normalized by the deviation of compaction moisture content from the optimum moisture content is proposed as performance criteria for a variety of engineered earth fills and special engineering assessment, prevention, and mitigation of geohazards e.g. earthen flood defense embankments.

  13. Protein Quality Control and Degradation in Cardiomyocytes

    PubMed Central

    Wang, Xuejun; Su, Huabo; Ranek, Mark J.

    2008-01-01

    The heart is constantly under stress and cardiomyocytes face enormous challenges to correctly fold nascent polypeptides and keep mature proteins from denaturing. To meet the challenge, cardiomyocytes have developed multi-layered protein quality control (PQC) mechanisms which are carried out primarily by chaperones and ubiquitin-proteasome system mediated proteolysis. Autophagy may also participate in PQC in cardiomyocytes, especially under pathological conditions. Cardiac PQC often becomes inadequate in heart disease, which may play an important role in the development of congestive heart failure. PMID:18495153

  14. DOE standard: Quality assurance inspection and testing of HEPA filters

    SciTech Connect

    1999-02-01

    This standard establishes essential elements for the quality assurance inspection and testing of HEPA filters by US Department of Energy (DOE)-accepted Filter Test Facilities (FTF). The standard specifies HEPA filter quality assurance inspection and testing practices established in DOE-STD-3022-98, DOE HEPA Filter Test Program, and provides a basis for the preparation of written operating procedures for primary FTF functions.

  15. Distributed Sensor Architecture for Intelligent Control that Supports Quality of Control and Quality of Service

    PubMed Central

    Poza-Lujan, Jose-Luis; Posadas-Yagüe, Juan-Luis; Simó-Ten, José-Enrique; Simarro, Raúl; Benet, Ginés

    2015-01-01

    This paper is part of a study of intelligent architectures for distributed control and communications systems. The study focuses on optimizing control systems by evaluating the performance of middleware through quality of service (QoS) parameters and the optimization of control using Quality of Control (QoC) parameters. The main aim of this work is to study, design, develop, and evaluate a distributed control architecture based on the Data-Distribution Service for Real-Time Systems (DDS) communication standard as proposed by the Object Management Group (OMG). As a result of the study, an architecture called Frame-Sensor-Adapter to Control (FSACtrl) has been developed. FSACtrl provides a model to implement an intelligent distributed Event-Based Control (EBC) system with support to measure QoS and QoC parameters. The novelty consists of using, simultaneously, the measured QoS and QoC parameters to make decisions about the control action with a new method called Event Based Quality Integral Cycle. To validate the architecture, the first five Braitenberg vehicles have been implemented using the FSACtrl architecture. The experimental outcomes, demonstrate the convenience of using jointly QoS and QoC parameters in distributed control systems. PMID:25723145

  16. Quality Assurance Protocol for AFCI Advanced Structural Materials Testing

    SciTech Connect

    Busby, Jeremy T

    2009-05-01

    application of NQA-1 requirements at the site. The current program is being revised to incorporate changes imposed through the recently revised AFCI Technical Integration Office QA requirements. Testing conducted under the AFCI QA program for the advanced structural materials effort shall incorporate the following quality assurance expectations: (1) personnel are adequately trained to perform assigned work; (2) activities are controlled to ensure consistency of results; (3) records necessary to substantiate how the work was performed are maintained (dedicated laboratory notebooks will be used); (4) the pedigree and traceability of the various tested materials are maintained throughout the described processes using consistent sample numbering and adequate record keeping; (5) equipment with the potential to affect the quality of the planned work is calibrated and maintained in accordance with applicable operating requirements. In addition, all reporting or related dissemination by ORNL personnel of the results of the work described in this subcontract shall be conducted in accordance with the requirements described or referenced in the ORNL Standards Based Management System subject area entitled Scientific and Technical Information. Reporting or publications at other institutions will be conducted in accordance with the requirements of that institution. Successful implementation of these protocols will provide a sound basis for future decisions and research. In addition, these steps will also help ensure that results can also be applied to licensing discussions at a future date.

  17. Improving Quality of Seal Leak Test Product using Six Sigma

    NASA Astrophysics Data System (ADS)

    Luthfi Malik, Abdullah; Akbar, Muhammad; Irianto, Dradjad

    2016-02-01

    Seal leak test part is a polyurethane material-based product. Based on past data, defect level of this product was 8%, higher than the target of 5%. Quality improvement effort was done using six sigma method that included phases of define, measure, analyse, improve, and control. In the design phase, a Delphi method was used to identify factors that were critical to quality. In the measure phase, stability and process capability was measured. Fault tree analysis (FTA) and failure mode and effect analysis (FMEA) were used in the next phase to analize the root cause and to determine the priority issues. Improve phase was done by compiling, selecting, and designing alternative repair. Some improvement efforts were identified, i.e. (i) making a checklist for maintenance schedules, (ii) making written reminder form, (iii) modifying the SOP more detail, and (iv) performing a major service to the vacuum machine. To ensure the continuity of improvement efforts, some control activities were executed, i.e. (i) controlling, monitoring, documenting, and setting target frequently, (ii) implementing reward and punishment system, (iii) adding cleaning tool, and (iv) building six sigma organizational structure.

  18. A Litmus Test of Academic Quality

    ERIC Educational Resources Information Center

    Orkodashvili, Mariam

    2009-01-01

    The paper discusses the major issues connected with the accreditation procedures in higher education system in the U.S. The questions raised are as follows: what are the reliable and credible indicators of quality instruction that could be measured in the process of accreditation of higher education institutions? How does greater transparency in…

  19. A rigorous testing methodology for control systems

    NASA Technical Reports Server (NTRS)

    Lewin, Andrew W.

    1991-01-01

    This paper discusses the development of a generalized verification testing methodology as applied to control systems. The methodology is based upon determining inputs that rigorously test each element of a system in order to verify that it has been specified properly. The methodology was successfully applied to testing of Boeing 737 autoland control system.

  20. Quality assurance of absorbed energy in Charpy impact test

    NASA Astrophysics Data System (ADS)

    Rocha, C. L. F.; Fabricio, D. A. K.; Costa, V. M.; Reguly, A.

    2016-07-01

    In order to ensure the quality assurance and comply with standard requirements, an intralaboratory study has been performed for impact Charpy tests, involving two operators. The results based on ANOVA (Analysis of Variance) and Normalized Error statistical techniques pointed out that the execution of the tests is appropriate, because the implementation of quality assurance methods showed acceptable results.

  1. 7 CFR 58.141 - Alternate quality control program.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 3 2010-01-01 2010-01-01 false Alternate quality control program. 58.141 Section 58... Service 1 Quality Specifications for Raw Milk § 58.141 Alternate quality control program. When a plant has in operation an acceptable quality program, at the producer level, which is approved by...

  2. 7 CFR 58.141 - Alternate quality control program.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 3 2011-01-01 2011-01-01 false Alternate quality control program. 58.141 Section 58... Service 1 Quality Specifications for Raw Milk § 58.141 Alternate quality control program. When a plant has in operation an acceptable quality program, at the producer level, which is approved by...

  3. Quality Control, Quality Assurance, and Quality Improvement-What is the Difference and Why Should Compounding Pharmacies Care?

    PubMed

    Cabaleiro, Joe

    2009-01-01

    This article provides scenarios of three different pharmacies in the areas of quality control, quality assurance, and quality improvement. The scenarios show the importance that each pharmacy placed on a problem of dented capsules and the potential impact that an unresolved problem can have on a compounding pharmacy's business. Although this article focuses on one particular procedure, the purpose of th article is to help pharmacists understand the differences between quality control, quality assurance, and quality improvement. PMID:23966522

  4. Data quality control of ADSN Broadband stations

    NASA Astrophysics Data System (ADS)

    Alili, Azouaou; Yelles-chaouche, Abd el karim; Allili, Toufik; Messemen, Walid

    2014-05-01

    In this work we present the analysis of continuous waveform of the Algerian digital seismic network recorded during five years from 2008 to 2013 for twenty broadband stations using the power spectral densities (PSDs) and their corresponding probability density functions (PDFs) algorithm of McNamara, and Buland (2004). ADSN Broadband stations data quality is one main concern and interest of ADSN technical team. Indeed, the quality of the data from broadband stations is continuously controlled in quasi-realtime using "PQLX" (Pascal Quick Look eXtended) software to compute the PDFs and PSDs during the operation of the stations at different frequency range. At each station the level of noise is shown, which we can see diurnal and seasonal variation. From the data analysis, most of the ADSN Broadband stations display good records in the several frequency domains in relation with their site installation. However some of stations near the urban areas could present some noisy disturbances. This led sometimes to generate some ghost events. In the low frequency, some stations could be still influenced by the temperature variations. This long period of records from 2008 to 2013, led us to analyze and control the several stations year by year taking into account the seasons and to know about their work during five years. This analysis is also very important to improve in the future quality of station installation and choose the optimal station design in aim to reduce cultural noise and large fluctuation of temperature and pressure. Key words: PQLX, PDFs, PSDs, Broad Band

  5. Plastic optical fibre sensor for quality control in food industry

    NASA Astrophysics Data System (ADS)

    Novo, C.; Bilro, L.; Ferreira, R.; Alberto, N.; Antunes, P.; Leitão, C.; Nogueira, R.; Pinto, J. L.

    2013-05-01

    The present work addresses the need for new devices felt in the context of quality control, especially in the food industry. Due to the spectral dependence of the attenuation coefficient, a novel dual-parameter sensor for colour and refractive index was developed and tested. The sensor employs plastic optical fibres to measure the transmitted optical power in three measurement cells each with a different incident wavelength. The performance of the sensor was tested using several dyes at different concentrations and aqueous solutions of glycerine and ethanol. Results show that this technique allows the monitoring of refractive index and colour without cross-sensitivity.

  6. Testing for Controlled Rapid Pressurization

    DOE Data Explorer

    Steven Knudsen

    2014-09-03

    Borehole W1 is a NQ core hole drilled at our test site in Socorro. The rock is rhyolite. Borehole W1 which was used to test gas-gas explosive mixtures is 55 feet deep with casing (pinkish in the drawing) set to 35 feet. The model is a representation of the borehole and the holes we cored around the central borehole after the test. The brown colored core holes showed dye when we filled W1 with water and slightly pressurized it. This indicates there was some path between W1 and the colored core hole. The core holes are shown to their TD in the drawing. The green plane is a fracture plane which we believe is the result of the explosions of the gas mixture in W1. Data resource is a 2D .pdf Solid Works Drawing of borehole w-1

  7. 46 CFR 164.019-13 - Production quality control requirements.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 6 2013-10-01 2013-10-01 false Production quality control requirements. 164.019-13....019-13 Production quality control requirements. (a) General. Each component manufacturer shall establish procedures for maintaining quality control of the materials used in production,...

  8. 46 CFR 164.019-13 - Production quality control requirements.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 6 2014-10-01 2014-10-01 false Production quality control requirements. 164.019-13....019-13 Production quality control requirements. (a) General. Each component manufacturer shall establish procedures for maintaining quality control of the materials used in production,...

  9. 46 CFR 164.019-13 - Production quality control requirements.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 6 2010-10-01 2010-10-01 false Production quality control requirements. 164.019-13....019-13 Production quality control requirements. (a) General. Each component manufacturer shall establish procedures for maintaining quality control of the materials used in production,...

  10. 14 CFR 145.211 - Quality control system.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Quality control system. 145.211 Section 145...) SCHOOLS AND OTHER CERTIFICATED AGENCIES REPAIR STATIONS Operating Rules § 145.211 Quality control system. (a) A certificated repair station must establish and maintain a quality control system acceptable...

  11. 14 CFR 145.211 - Quality control system.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 3 2011-01-01 2011-01-01 false Quality control system. 145.211 Section 145...) SCHOOLS AND OTHER CERTIFICATED AGENCIES REPAIR STATIONS Operating Rules § 145.211 Quality control system. (a) A certificated repair station must establish and maintain a quality control system acceptable...

  12. 46 CFR 164.019-13 - Production quality control requirements.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 6 2011-10-01 2011-10-01 false Production quality control requirements. 164.019-13....019-13 Production quality control requirements. (a) General. Each component manufacturer shall establish procedures for maintaining quality control of the materials used in production,...

  13. Mechanical and dosimetric quality control for computer controlled radiotherapy treatment equipment.

    PubMed

    Thompson, A V; Lam, K L; Balter, J M; McShan, D L; Martel, M K; Weaver, T A; Fraass, B A; Ten Haken, R K

    1995-05-01

    Modern computer controlled radiotherapy treatment equipment offers the possibility of delivering complex, multiple field treatments with minimal operator intervention, thus making multiple field conformal therapy practical. Conventional quality control programs are inadequate for this new technology, so new quality control procedures are needed. A reasonably fast, sensitive, and complete daily quality control program has been developed in our clinic that includes nearly automated mechanical as well as dosimetric tests. Automated delivery of these quality control fields is performed by the control system of the MM50 racetrack microtron, directed by the CCRS sequence processor [D. L. McShan and B. A. Fraass, Proceedings of the XIth International Conference on the use of computers in Radiation Therapy, 20-24 March 1994, Manchester, U.K. (North Western Medical Physics Department, Manchester, U.K., 1994), pp. 210-211], which controls the treatment process. The mechanical tests involve multiple irradiations of a single film to check the accuracy and reproducibility of the computer controlled setup of gantry and collimator angles, table orientation, collimator jaws, and multileaf collimator shape. The dosimetric tests, which involve multiple irradiations of an array of ionization chambers in a commercial dose detector (Keithly model 90100 Tracker System) rigidly attached to the head of the treatment gantry, check the output and symmetry of the treatment unit as a function of gantry and collimator angle and other parameters. For each of the dosimetric tests, readings from the five ionization chambers are automatically read out, stored, and analyzed by the computer, along with the geometric parameters of the treatment unit for that beam.(ABSTRACT TRUNCATED AT 250 WORDS) PMID:7643792

  14. Quality control of the RMI's AWS wind observations

    NASA Astrophysics Data System (ADS)

    Bertrand, Cédric; González Sotelino, Luis; Journée, Michel

    2016-02-01

    Wind observations are important for a wide range of domains including among others meteorology, agriculture and extreme wind engineering. To ensure the provision of high quality surface wind data over Belgium, a new semi-automated data quality control (QC) has been developed and applied to wind observations from the automated weather stations operated by the Royal Meteorological Institute of Belgium. This new QC applies to 10 m 10 min averaged wind speed and direction, 10 m gust speed and direction, 2 m 10 min averaged wind speed and 30 m 10 min averaged wind speed records. After an existence test, automated procedures check the data for limits consistency, internal consistency, temporal consistency and spatial consistency. At the end of the automated QC, a decision algorithm attributes a flag to each particular data point. Each day, the QC staff analyzes the preceding day's observations in the light of the assigned quality flags.

  15. 40 CFR 75.21 - Quality assurance and quality control requirements.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 16 2010-07-01 2010-07-01 false Quality assurance and quality control... PROGRAMS (CONTINUED) CONTINUOUS EMISSION MONITORING Operation and Maintenance Requirements § 75.21 Quality assurance and quality control requirements. (a) Continuous emission monitoring systems. The owner...

  16. Automated quality control in a file-based broadcasting workflow

    NASA Astrophysics Data System (ADS)

    Zhang, Lina

    2014-04-01

    Benefit from the development of information and internet technologies, television broadcasting is transforming from inefficient tape-based production and distribution to integrated file-based workflows. However, no matter how many changes have took place, successful broadcasting still depends on the ability to deliver a consistent high quality signal to the audiences. After the transition from tape to file, traditional methods of manual quality control (QC) become inadequate, subjective, and inefficient. Based on China Central Television's full file-based workflow in the new site, this paper introduces an automated quality control test system for accurate detection of hidden troubles in media contents. It discusses the system framework and workflow control when the automated QC is added. It puts forward a QC criterion and brings forth a QC software followed this criterion. It also does some experiments on QC speed by adopting parallel processing and distributed computing. The performance of the test system shows that the adoption of automated QC can make the production effective and efficient, and help the station to achieve a competitive advantage in the media market.

  17. Quantitative assessment of computed radiography quality control parameters.

    PubMed

    Rampado, O; Isoardi, P; Ropolo, R

    2006-03-21

    Quality controls for testing the performance of computed radiography (CR) systems have been recommended by manufacturers and medical physicists' organizations. The purpose of this work was to develop a set of image processing tools for quantitative assessment of computed radiography quality control parameters. Automatic image analysis consisted in detecting phantom details, defining regions of interest and acquiring measurements. The tested performance characteristics included dark noise, uniformity, exposure calibration, linearity, low-contrast and spatial resolution, spatial accuracy, laser beam function and erasure thoroughness. CR devices from two major manufacturers were evaluated. We investigated several approaches to quantify the detector response uniformity. We developed methods to characterize the spatial accuracy and resolution properties across the entire image area, based on the Fourier analysis of the image of a fine wire mesh. The implemented methods were sensitive to local blurring and allowed us to detect a local distortion of 4% or greater in any part of an imaging plate. The obtained results showed that the developed image processing tools allow us to implement a quality control program for CR with short processing time and with absence of subjectivity in the evaluation of the parameters. PMID:16510964

  18. Flight Test Approach to Adaptive Control Research

    NASA Technical Reports Server (NTRS)

    Pavlock, Kate Maureen; Less, James L.; Larson, David Nils

    2011-01-01

    The National Aeronautics and Space Administration s Dryden Flight Research Center completed flight testing of adaptive controls research on a full-scale F-18 testbed. The validation of adaptive controls has the potential to enhance safety in the presence of adverse conditions such as structural damage or control surface failures. This paper describes the research interface architecture, risk mitigations, flight test approach and lessons learned of adaptive controls research.

  19. 21 CFR 866.5910 - Quality control material for cystic fibrosis nucleic acid assays.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... Test Systems § 866.5910 Quality control material for cystic fibrosis nucleic acid assays. (a... cystic fibrosis nucleic acid assays is a device intended to help monitor reliability of a test system by... testing. This type of device includes recombinant, synthetic, and cell line-based DNA controls....

  20. 21 CFR 866.5910 - Quality control material for cystic fibrosis nucleic acid assays.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... Test Systems § 866.5910 Quality control material for cystic fibrosis nucleic acid assays. (a... cystic fibrosis nucleic acid assays is a device intended to help monitor reliability of a test system by... testing. This type of device includes recombinant, synthetic, and cell line-based DNA controls....

  1. 21 CFR 866.5910 - Quality control material for cystic fibrosis nucleic acid assays.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... Test Systems § 866.5910 Quality control material for cystic fibrosis nucleic acid assays. (a... cystic fibrosis nucleic acid assays is a device intended to help monitor reliability of a test system by... testing. This type of device includes recombinant, synthetic, and cell line-based DNA controls....

  2. 21 CFR 866.5910 - Quality control material for cystic fibrosis nucleic acid assays.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... Test Systems § 866.5910 Quality control material for cystic fibrosis nucleic acid assays. (a... cystic fibrosis nucleic acid assays is a device intended to help monitor reliability of a test system by... testing. This type of device includes recombinant, synthetic, and cell line-based DNA controls....

  3. 21 CFR 866.5910 - Quality control material for cystic fibrosis nucleic acid assays.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... Test Systems § 866.5910 Quality control material for cystic fibrosis nucleic acid assays. (a... cystic fibrosis nucleic acid assays is a device intended to help monitor reliability of a test system by... testing. This type of device includes recombinant, synthetic, and cell line-based DNA controls....

  4. Remote control missile model test

    NASA Technical Reports Server (NTRS)

    Allen, Jerry M.; Shaw, David S.; Sawyer, Wallace C.

    1989-01-01

    An extremely large, systematic, axisymmetric body/tail fin data base was gathered through tests of an innovative missile model design which is described herein. These data were originally obtained for incorporation into a missile aerodynamics code based on engineering methods (Program MISSILE3), but can also be used as diagnostic test cases for developing computational methods because of the individual-fin data included in the data base. Detailed analysis of four sample cases from these data are presented to illustrate interesting individual-fin force and moment trends. These samples quantitatively show how bow shock, fin orientation, fin deflection, and body vortices can produce strong, unusual, and computationally challenging effects on individual fin loads. Comparisons between these data and calculations from the SWINT Euler code are also presented.

  5. [Evaluating an internal quality control procedure: application to multidimensional control].

    PubMed

    Marquis, P; Masseyeff, R

    2002-01-01

    Internal quality control keeps in constant evolution in the industrial world. Introducing in clinical chemistry new QC methods derived from the industrial practice raises the point of the means for their evaluation. The main evaluation criteria are discussed in this paper. The importance of ARL (average run length) as a key-criterion of the efficiency of a quality control procedure is stressed. These principles were applied to the multivariate approach of multilevel control with the Hotelling's T2. This method led to a better detection of random errors than the independently managed conventional Shewhart (Levey- Jennings) charts. Applied to systematic errors, both methods gave similar results with a certain lack of sensitivity. However the multivariate method can be sensitised using EWMA (exponentially weighted moving average), a method specific for improved bias detection. EWMA efficiency outperforms that of the older systems of rules. Moreover, in any kind of error, multivariate approach secures a well-defined false rejection rate, whereas this rate is dependant on unknown inter-level correlation coefficients in conventional QC. PMID:12368148

  6. Repeated controlled rockfall trajectory testing

    NASA Astrophysics Data System (ADS)

    Volkwein, Axel; Krummenacher, Barbara; Gerber, Werner; Lardon, Jessica; Gees, Fabio; Brügger, Lucas; Ott, Thomas

    2015-04-01

    The variability of rockfall trajectories regarding their travel paths, velocities, run out distances and jump heights requires statistical and stochastic methods for both the analysis of field values and numerical simulations. However, the perturbations mostly are considered only within the simulations because only few stochastic data are available coming from the field. This means, simulation software is calibrated based on the data of single rockfall events without the knowledge whether the observed/recorded events were average or extreme ones. In a field study we now tested the conduction of rockfall tests on a natural slope using natural boulders. Each boulder was thrown several times from the same starting point. This procedure provides a view on the variability of the different trajectories. The outcome helps to better understand the rockfall process but more provides valuable datasets that can be used for the calibration of rockfall simulation models. The rockfall experiments were recorded using two high speed cameras, an internal independent high frequency data logging unit measuring 3D accelerations and 3D rotational velocities. An external so-called "Local Positioning System" enabled a live tracking of the blocks in the field. More than repetitions were achieved using mainly 4 different blocks. The presentation shows the first analysis of the experiments including validation of measurement systems, the natural variability of the rockfall tests and comparison with corresponding theory and simulations.

  7. The analytical control program for the NASA Space Station Freedom Environmental Control and Life Support System (ECLSS) Water Recovery Test

    NASA Technical Reports Server (NTRS)

    Tatara, James D.; Minton, Silvia

    1992-01-01

    NASA-Marshall has striven to maximize quality assurance and quality control measures in the course of Water Recovery Test (WRT) development for the Space Station Freedom ECLSS. The WRT was subjected to an independent analytical control program that is governed by the Analytical Control Test Plan and the Microbiological Methods for Water Recovery Testing Plan. Attention is given to analysis results for volatiles, sodium, and conductivity.

  8. Intelligent process quality control system into supply chain

    NASA Astrophysics Data System (ADS)

    Wang, Shijie; Jiang, Xingyu; Wang, Yingchun

    2010-01-01

    To cope with the challenges of monitoring dynamic and variable quality variation into supply chain, diagnosing the abnormal variation at the right moment, is a difficult problem that a enterprise in supply chain faces in process quality control. An intelligent process quality control mode into supply chain, which integrated quality prevention, analysis, diagnosis and adjustment, and corresponding functional modules and framework were all put forward. This mode dealt mainly with constructing and running intelligent quality control system, such as the theory of similarity manufacturing, Statistical Process Control (SPC), neural network. Furthermore, some key enabling technologies were studied in detail, including process quality analysis on-line based on similarity process and process quality diagnosis based on Elman and expert system of process quality adjustment. It is basis of realizing network, intelligent and automatic process quality control into supply.

  9. Intelligent process quality control system into supply chain

    NASA Astrophysics Data System (ADS)

    Wang, Shijie; Jiang, Xingyu; Wang, Yingchun

    2009-12-01

    To cope with the challenges of monitoring dynamic and variable quality variation into supply chain, diagnosing the abnormal variation at the right moment, is a difficult problem that a enterprise in supply chain faces in process quality control. An intelligent process quality control mode into supply chain, which integrated quality prevention, analysis, diagnosis and adjustment, and corresponding functional modules and framework were all put forward. This mode dealt mainly with constructing and running intelligent quality control system, such as the theory of similarity manufacturing, Statistical Process Control (SPC), neural network. Furthermore, some key enabling technologies were studied in detail, including process quality analysis on-line based on similarity process and process quality diagnosis based on Elman and expert system of process quality adjustment. It is basis of realizing network, intelligent and automatic process quality control into supply.

  10. Integrated quality control: implementation and validation of instrument function checks and procedural controls for a cartridge-based point-of-care system for critical care analysis.

    PubMed

    D'Orazio, Paul; Mansouri, Sohrab

    2013-03-01

    In this article, the process used to develop and validate an integrated quality-control system for a cartridge-based, point-of-care system for critical care analysis is outlined. Application of risk management principles has resulted in a quality control system using a combination of statistical quality control with onboard reference solutions and failure pattern recognition used to flag common failure modes during the analytical phase of the testing process. A combination of traditional external quality control, integrated quality control to monitor ongoing instrument functionality, operator training, and other laboratory-implemented monitors is most effective in controlling known failure modes during the testing process. PMID:23331731

  11. Evaluation program for secondary spacecraft cells: Initial evaluation tests of General Electric Company 6.0 ampere hour nickel-cadmium spacecraft cells with auxiliary electrodes for the atmospheric Explorer satellite C and D. [quality control testing

    NASA Technical Reports Server (NTRS)

    Harkness, J. D.

    1974-01-01

    The capacity of the cells ranged from 6.6 to 7.6 ampere hours during the three capacity tests. No voltage requirements or limits were exceeded during any portion of the test. All cells recovered to a voltage in excess of 1.193 volts during the 24-hour open-circuit portion of the internal short test. All the cells reached a pressure of 20 psia before reaching the voltage limit of 1.550 volts during the pressure versus capacity test. The average ampere/hours in and voltages at this pressure were 9.1 and 1.513, respectively. All cells exhibited pressure decay in the range of 1 to 5 psia during the last 30 minutes of the 1-hour open circuit stand. Average capacity out was 7.2 ampere/hours.

  12. [Improvement of routine works and quality control in mycobacterial laboratory].

    PubMed

    Suzuki, Katsuhiro; Higuchi, Takeshi

    2007-03-01

    Many new methods have been introduced into routine laboratory works in microbiology since 1990. Molecular biology, in particular, opened a new era and promoted a technician's skill much. PCR and hybridization technique have been ordinary one in many laboratories. Since old techniques such as smear and culture are still needed, amount of routine works is increasing gradually. Thus, improving efficiency and keeping quality of routine works are becoming more and more important issues. This symposium focused on such points, and four skilled technicians around Japan presented their own tips. 1. Coexistence of M. tuberculosis and M. avium complex (MAC) in the MGIT culture system: Yasushi WATANABE (Clinical Laboratory Division, NHO Nishi-Niigata Chuo National Hospital). Sputum samples of some tuberculosis patients yielded only MAC in the MGIT culture system. Such co-infected cases presented problems to mislead proper treatment and infection control. The detection rate of MAC was significantly high, and the growth speed of MAC was significantly rapid in the MGIT culture system, compared to those of M. tuberculosis. Additionally, M. tuberculosis was not detected with even more quantity than MAC in the small amount of mixed samples. Higher sensitivity and growth speed of MAC are the important characteristics of the MGIT system. 2. Internal quality control with ordinary examination results: Akio AONO (Department of Clinical Examination, Double-Barred Cross Hospital, Japan Anti-Tuberculosis Association). Our laboratory utilizes ordinary examination results as the internal quality control for specimen pretreatment, culture, and drug susceptibility testing. The contamination rate of MGIT culture system is useful for the evaluation of the decontamination process. It was 6.3% on average in our laboratory in 2005. The number of drug resistant strains is also useful to assess the performance of drug susceptibility testing. The incidence of each anti-tuberculosis drug resistance

  13. Expediting the method development and quality control of reversed-phase liquid chromatography electrospray ionization mass spectrometry for pharmaceutical analysis by using an LC/MS performance test mix.

    PubMed

    Tang, L; Fitch, W L; Alexander, M S; Dolan, J W

    2000-11-01

    Mass spectrometry combined with liquid chromatography (LC/MS) has become an important analytical methodology in both pharmaceutical and biomolecule analyses. LC/MS, especially with reversed-phase HPLC (RP-LC), is extensively used in the separation and structural identification of pharmaceutical samples. However, many parameters have to be considered when a new LC/MS method is developed for either separation and structural analysis of unknown mixtures or quantitative analysis of a set of known compounds in an assay. The optimization of a new LC/MS method can be a time-consuming process. A novel kit-LC/MS performance test mix-composed of aspartame, cortisone, reserpine, and dioctyl phthalate has been developed to accelerate the process of establishing a new RP-LC/MS method. The LC/MS mix makes the evaluation and validation of an LC/MS method more efficient and easier. It also simplifies the quality control procedure for an LC/MS method in use. PMID:11080866

  14. mRNA quality control goes transcriptional

    PubMed Central

    Kilchert, Cornelia; Vasiljeva, Lidia

    2013-01-01

    Eukaryotic mRNAs are extensively processed to generate functional transcripts, which are 5′ capped, spliced and 3′ polyadenylated. Accumulation of unprocessed (aberrant) mRNAs can be deleterious for the cell, hence processing fidelity is closely monitored by QC (quality control) mechanisms that identify erroneous transcripts and initiate their selective removal. Nucleases including Xrn2/Rat1 and the nuclear exosome have been shown to play an important role in the turnover of aberrant mRNAs. Recently, with the growing appreciation that mRNA processing occurs concomitantly with polII (RNA polymerase II) transcription, it has become evident that QC acts at the transcriptional level in addition to degrading aberrant RNAs. In the present review, we discuss mechanisms that allow cells to co-transcriptionally initiate the removal of RNAs as well as down-regulate transcription of transcripts where processing repeatedly fails. PMID:24256272

  15. Quality control in the "flash" process.

    PubMed

    1985-03-01

    This article has briefly discussed the three basic types of sterilization monitoring systems--mechanical, chemical, and biological. Mechanical indicators help tell you that the sterilizer is working. Chemical indicators provide you with immediate information in each "flash" load that the conditions necessary for steam sterilization were present. Biological indicators tell you that microorganisms were killed. For maximum assurance that the conditions necessary for steam sterilization are present and that non-sterile instruments are not inadvertently used, each "flash" sterilizer should be monitored daily with biological indicators and each "flash" load with chemical indicators. This quality control monitoring program should give the O.R. staff confidence that their "flash" sterilization process is working. PMID:10271096

  16. Mitochondrial Quality Control as a Therapeutic Target.

    PubMed

    Suliman, Hagir B; Piantadosi, Claude A

    2016-01-01

    In addition to oxidative phosphorylation (OXPHOS), mitochondria perform other functions such as heme biosynthesis and oxygen sensing and mediate calcium homeostasis, cell growth, and cell death. They participate in cell communication and regulation of inflammation and are important considerations in aging, drug toxicity, and pathogenesis. The cell's capacity to maintain its mitochondria involves intramitochondrial processes, such as heme and protein turnover, and those involving entire organelles, such as fusion, fission, selective mitochondrial macroautophagy (mitophagy), and mitochondrial biogenesis. The integration of these processes exemplifies mitochondrial quality control (QC), which is also important in cellular disorders ranging from primary mitochondrial genetic diseases to those that involve mitochondria secondarily, such as neurodegenerative, cardiovascular, inflammatory, and metabolic syndromes. Consequently, mitochondrial biology represents a potentially useful, but relatively unexploited area of therapeutic innovation. In patients with genetic OXPHOS disorders, the largest group of inborn errors of metabolism, effective therapies, apart from symptomatic and nutritional measures, are largely lacking. Moreover, the genetic and biochemical heterogeneity of these states is remarkably similar to those of certain acquired diseases characterized by metabolic and oxidative stress and displaying wide variability. This biologic variability reflects cell-specific and repair processes that complicate rational pharmacological approaches to both primary and secondary mitochondrial disorders. However, emerging concepts of mitochondrial turnover and dynamics along with new mitochondrial disease models are providing opportunities to develop and evaluate mitochondrial QC-based therapies. The goals of such therapies extend beyond amelioration of energy insufficiency and tissue loss and entail cell repair, cell replacement, and the prevention of fibrosis. This review

  17. Development of methodology and technology for identifying and quantifying emission products from open-burning and open-detonation thermal-treatment methods. Field Test Series A, B, and C. Volume 2, Part A. Quality assurance and quality control. Final report, Dec 88-Jan 92

    SciTech Connect

    Johnson, M.

    1992-01-01

    The report describes the quality assurance/quality control program conducted during 1990 field testing which supported the OB/OD Thermal Treatment Methods Study. The QA/QC program encompassed sample collection, preparation, storage, extraction, analytical instrument operation, data reduction, statistical data analyses and interpretation. Samples included atmosphere collected in evacuated stainless steel canisters, soil, and Teflon coated-glass-fiber media. The supercritical fluid chromatograph and gas chromatograph with mass spectrometers were the principal laboratory analytical instruments used during these field tests. Real-time instruments detected and quantified CO, C02, NO, NO2, and NOx. Near-real-time analyses were accomplished by use of a Teflon bag in which samples of the plume were collected for analyses during testing operations. Sample-tracking was conducted using a system which permitted precise identification of individual specimens from collection through analyses or archiving. Analysis of atmosphere and soil samples spiked by the U.S. Environment Protection Agency (EPA) reflected a degree of accuracy well within acceptable limits. Open burning; open detonation; OB/OD; TNT; double base propellant; manufacturers residue propellant; air emissions; thermal treatment; carbon balance; and emission factor.

  18. 10 CFR 72.162 - Test control.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 2 2012-01-01 2012-01-01 false Test control. 72.162 Section 72.162 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) LICENSING REQUIREMENTS FOR THE INDEPENDENT STORAGE OF SPENT NUCLEAR FUEL... Test control. The licensee, applicant for a license, certificate holder, and applicant for a CoC...

  19. 10 CFR 72.162 - Test control.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 2 2013-01-01 2013-01-01 false Test control. 72.162 Section 72.162 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) LICENSING REQUIREMENTS FOR THE INDEPENDENT STORAGE OF SPENT NUCLEAR FUEL... Test control. The licensee, applicant for a license, certificate holder, and applicant for a CoC...

  20. 10 CFR 72.162 - Test control.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 2 2014-01-01 2014-01-01 false Test control. 72.162 Section 72.162 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) LICENSING REQUIREMENTS FOR THE INDEPENDENT STORAGE OF SPENT NUCLEAR FUEL... Test control. The licensee, applicant for a license, certificate holder, and applicant for a CoC...

  1. 10 CFR 72.162 - Test control.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false Test control. 72.162 Section 72.162 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) LICENSING REQUIREMENTS FOR THE INDEPENDENT STORAGE OF SPENT NUCLEAR FUEL... Test control. The licensee, applicant for a license, certificate holder, and applicant for a CoC...

  2. Quality control standards in PGD and PGS.

    PubMed

    SenGupta, S B; Dhanjal, S; Harper, J C

    2016-03-01

    Preimplantation genetic diagnosis (PGD) aims to test the embryo for specific conditions before implantation in couples at risk of transmitting genetic abnormality to their offspring. The couple must undergo IVF procedures to generate embryos in vitro. The embryos can be biopsied at either the zygote, cleavage or blastocyst stage. Preimplantation genetic screening uses the same technology to screen for chromosome abnormalities in embryos from patients undergoing IVF procedures as a method of embryo selection. Fluorescence in-situ hybridization was originally used for chromosome analysis, but has now been replaced by array comparative genomic hybridization or next generation sequencing. For the diagnosis of single gene defects, polymerase chain reaction is used and has become highly developed; however, single nucleotide polymorphism arrays for karyomapping have recently been introduced. A partnership between IVF laboratories and diagnostic centres is required to carry out PGD and preimplantation genetic screening. Accreditation of PGD diagnostic laboratories is important. Accreditation gives IVF centres an assurance that the diagnostic tests conform to specified standards. ISO 15189 is an international laboratory standard specific for medical laboratories. A requirement for accreditation is to participate in external quality assessment schemes. PMID:26776824

  3. Chapter 5: Quality assurance/quality control in stormwater sampling

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Sampling the quality of stormwater presents unique challenges because stormwater flow is relatively short-lived with drastic variability. Furthermore, storm events often occur with little advance warning, outside conventional work hours, and under adverse weather conditions. Therefore, most stormwat...

  4. Predictive Control of Speededness in Adaptive Testing

    ERIC Educational Resources Information Center

    van der Linden, Wim J.

    2009-01-01

    An adaptive testing method is presented that controls the speededness of a test using predictions of the test takers' response times on the candidate items in the pool. Two different types of predictions are investigated: posterior predictions given the actual response times on the items already administered and posterior predictions that use the…

  5. 21 CFR 111.117 - What quality control operations are required for equipment, instruments, and controls?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 2 2010-04-01 2010-04-01 false What quality control operations are required for equipment, instruments, and controls? 111.117 Section 111.117 Food and Drugs FOOD AND DRUG ADMINISTRATION... and Process Control System: Requirements for Quality Control § 111.117 What quality control...

  6. 21 CFR 111.117 - What quality control operations are required for equipment, instruments, and controls?

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 21 Food and Drugs 2 2012-04-01 2012-04-01 false What quality control operations are required for equipment, instruments, and controls? 111.117 Section 111.117 Food and Drugs FOOD AND DRUG ADMINISTRATION... and Process Control System: Requirements for Quality Control § 111.117 What quality control...

  7. Rethinking Teaching and Testing: Quality in the Classroom.

    ERIC Educational Resources Information Center

    Cooke, Brian P.

    Changes in the way contemporary organizations conduct business demand a concurrent redesign of teaching and testing methods. Maintaining instructional quality must begin with knowledge of the quality revolution in contemporary organizations in order to meet the demands of these organizations for self-confident, self-directed, self-motivated,…

  8. Quality-controlled Subject Gateways: Definitions, Typologies, Empirical Overview.

    ERIC Educational Resources Information Center

    Koch, Traugott

    2000-01-01

    "Quality-controlled subject gateways" are Internet services which apply quality measures to support systematic resource discovery. A main goal is to provide high quality subject access through indexing resources using controlled vocabularies and by offering a deep classification structure for advanced searching and browsing. Provides an empirical…

  9. 30 CFR 28.31 - Quality control plans; contents.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ..., EVALUATION, AND APPROVAL OF MINING PRODUCTS FUSES FOR USE WITH DIRECT CURRENT IN PROVIDING SHORT-CIRCUIT...) Each quality control plan shall contain provisions for the management of quality, including: (1... 30 Mineral Resources 1 2011-07-01 2011-07-01 false Quality control plans; contents. 28.31...

  10. 30 CFR 28.31 - Quality control plans; contents.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ..., EVALUATION, AND APPROVAL OF MINING PRODUCTS FUSES FOR USE WITH DIRECT CURRENT IN PROVIDING SHORT-CIRCUIT...) Each quality control plan shall contain provisions for the management of quality, including: (1... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Quality control plans; contents. 28.31...

  11. 75 FR 41874 - Quality Control for Rental Assistance Subsidy Determinations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-19

    ... URBAN DEVELOPMENT Quality Control for Rental Assistance Subsidy Determinations AGENCY: Office of the... agency's estimate of the burden of the proposed collection of information; (3) Enhance the quality.... This notice also lists the following information: Title of Proposal: Quality Control for...

  12. 14 CFR 21.147 - Changes in quality control system.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 1 2011-01-01 2011-01-01 false Changes in quality control system. 21.147 Section 21.147 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION... quality control system. After the issue of a production certificate, each change to the quality...

  13. 14 CFR 21.147 - Changes in quality control system.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Changes in quality control system. 21.147 Section 21.147 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION... quality control system. After the issue of a production certificate, each change to the quality...

  14. US quality control in Italy: present and future

    NASA Astrophysics Data System (ADS)

    Balbis, S.; Musacchio, C.; Guiot, C.; Spagnolo, R.

    2011-02-01

    US diagnostic equipments are widely diffused in Italy but, in spite of recommendations (e.g. ISPESL-Ministry of Health (1999) and SIRM (Società Italiana di Radiologia Medica, 2004), US quality controls are restricted to only a few public sanitary structure and a national (or even regional) quality assurance program for testing the performances of the US equipments is still missing. A joint Research Centre among the three Piedmontese Universities and INRIM, partially funded by Regione Piemonte, has been established in 2009 as Reference Centre for Medical Ultrasounds (CRUM). In addition to research, development and training tasks, the Centre aims at the local diffusion of the quality assurance in clinical US equipments. According to data from the Ministry of Health (2006), around 7 % of the Italian US diagnostic equipments (946 over 13526) are located in Piedmont: mostly (75.6%) in public hospitals, 9.3 % in conventionated hospitals, 4.3% in public and 10.8% in private territorial structures. The goal is the provision of a regional database, which progressively includes data related to acceptance test, status and QC tests and maintenance, in order to drive equipment turnover and carefully monitoring the overall equipment efficiency. Moreover, facilities are available at CRUM for monitoring both beam geometry and acoustic power and performing quantitative assessment of the delivered energy intensity.

  15. A Systems Engineering Approach to Quality Assurance for Aerospace Testing

    NASA Technical Reports Server (NTRS)

    Shepherd, Christena C.

    2015-01-01

    On the surface, it appears that AS91001 has little to say about how to apply a Quality Management System (QMS) to major aerospace test programs (or even smaller ones). It also appears that there is little in the quality engineering Body of Knowledge (BOK)2 that applies to testing, unless it is nondestructive examination (NDE), or some type of lab or bench testing associated with the manufacturing process. However, if one examines: a) how the systems engineering (SE) processes are implemented throughout a test program; and b) how these SE processes can be mapped to the requirements of AS9100, a number of areas for involvement of the quality professional are revealed. What often happens is that quality assurance during a test program is limited to inspections of the test article; what could be considered a manufacturing al fresco approach. This limits the quality professional and is a disservice to the programs and projects, since there are a number of ways that quality can enhance critical processes, and support efforts to improve risk reduction, efficiency and effectiveness.

  16. Testing a Constrained MPC Controller in a Process Control Laboratory

    ERIC Educational Resources Information Center

    Ricardez-Sandoval, Luis A.; Blankespoor, Wesley; Budman, Hector M.

    2010-01-01

    This paper describes an experiment performed by the fourth year chemical engineering students in the process control laboratory at the University of Waterloo. The objective of this experiment is to test the capabilities of a constrained Model Predictive Controller (MPC) to control the operation of a Double Pipe Heat Exchanger (DPHE) in real time.…

  17. CR mammography: Design and implementation of a quality control program

    SciTech Connect

    Moreno-Ramirez, A.; Brandan, M. E.; Villasenor-Navarro, Y.; Galvan, H. A.; Ruiz-Trejo, C.

    2012-10-23

    Despite the recent acquisition of significant quantities of computed radiography CR equipment for mammography, Mexican regulations do not specify the performance requirements for digital systems such as those of CR type. The design of a quality control program QCP specific for CR mammography systems was thus considered relevant. International protocols were taken as reference to define tests, procedures and acceptance criteria. The designed QCP was applied in three CR mammography facilities. Important deficiencies in spatial resolution, noise, image receptor homogeneity, artifacts and breast thickness compensation were detected.

  18. Quality control of laboratory results in real time.

    PubMed

    Picco, W; Pinna Pintor, L; Baruzzo, G; Pistono, O; Triumbari, F; Pinna Pintor, P

    1992-03-01

    An integrated informatic system may have an important role in identifying and reducing those errors which affect the reliability of laboratory results. The present work reports on the development of a system that, by means of a computer connected with laboratory instrumentation, allows monitoring of global error (bias, random, gross) using classical statistical quality control systems, integrated by auxiliary methods built on a database stored in the computer. These methods succeeded in greatly reducing bias and random error in the most frequent laboratory tests. Further methods to find, quantify, and reduce the gross and extra-analytical errors are under development. PMID:1576336

  19. Star testing: a novel evaluation of intraocular lens optical quality

    PubMed Central

    Mitchell, L; Molteno, A C B; Bevin, T H; Sanderson, G

    2006-01-01

    Background Despite the importance of optical quality of an intraocular lens (IOL) on visual outcomes following cataract surgery, objective data on their optical quality are not readily available, and manufacturing standards are industry regulated. The star test is a classic test of optical quality based on examination of the Airy disc and expanded diffraction rings of a point source of light, used mainly for telescope and microscope objectives. Methods A physical model eye cell allowed star testing of IOLs under conditions similar to the optical environment in which they operate. 18 IOLs were tested and results compared to actual images produced by these lenses in the model eye cell. Quantitative measures of star testing performance were developed. Results The optical performance of the IOLs varied, some performing very poorly. Most lenses (13/17) performed better in reverse orientation, while aberrations induced by the haptics of foldable IOLs were also detected. There was excellent correlation between actual images formed and star testing parameters. Conclusion Star testing IOLs was a novel biomedical application of a centuries old, inexpensive method. A concerning variation of optical quality was found, suggesting IOL optical performance data should be more readily available. Independent, authority mandated IOL optical quality standards should be developed, and results readily available to ophthalmologists. PMID:16622088

  20. Quality assurance standards for purchasing and inventory control.

    PubMed

    Soares, D P

    1985-03-01

    A process is described for quality assurance in pharmaceutical purchasing and inventory control. A quality assurance program should ensure that quality drugs are purchased at the lowest price, drug products are available when needed, the system is managed efficiently, internal controls are provided, drug products are stored under appropriate conditions, and laws, regulations, accreditation standards, and procedures are followed. To meet these objectives, product quality, vendor performance, the department's system of internal controls, purchasing data, and storage conditions should be monitored. A checklist for evaluating purchasing and inventory practices and a sample audit form listing quality assurance criteria, standards, procedures, and recommended actions are provided. A quality assurance program for pharmaceutical purchasing and inventory control should define institution-specific criteria and standards and use these standards for continual evaluation of all aspects of the purchasing and inventory control system. Documentation of quality assurance activities should be provided for use by the purchasing department, hospital administration, and regulatory bodies. PMID:3985026

  1. Timing control improves seabed survey data quality

    SciTech Connect

    Green, R.

    1996-04-01

    Seateam has completed development of and field-proven the Dolphin data acquisition and timing system for high-density surveys offshore. The Dolphin project was initiated to improve quality control of survey sensor data and ensure time synchronization, thus leading to faster turnaround of seabed terrain information. Data received from survey sensors is asynchronous, so the system must provide for data correlation. This includes establishment of data latency, i.e., the time difference between data creation and timing of the message at first-byte arrival at the recording system. Until recently, asynchronous data from multiple sensors was collected by a single computer, regardless of whether it had additional intelligent or non-intelligent serial cards. This computer was fully responsible for time stamping all incoming data, plus associated storage and distribution. Though this initially sufficed and is still applicable to low-density data, increasingly larger data volumes required an associated boost in the capability to time stamp data prior to eventual correction.

  2. Mitochondrial Quality Control and Muscle Mass Maintenance

    PubMed Central

    Romanello, Vanina; Sandri, Marco

    2016-01-01

    Loss of muscle mass and force occurs in many diseases such as disuse/inactivity, diabetes, cancer, renal, and cardiac failure and in aging-sarcopenia. In these catabolic conditions the mitochondrial content, morphology and function are greatly affected. The changes of mitochondrial network influence the production of reactive oxygen species (ROS) that play an important role in muscle function. Moreover, dysfunctional mitochondria trigger catabolic signaling pathways which feed-forward to the nucleus to promote the activation of muscle atrophy. Exercise, on the other hand, improves mitochondrial function by activating mitochondrial biogenesis and mitophagy, possibly playing an important part in the beneficial effects of physical activity in several diseases. Optimized mitochondrial function is strictly maintained by the coordinated activation of different mitochondrial quality control pathways. In this review we outline the current knowledge linking mitochondria-dependent signaling pathways to muscle homeostasis in aging and disease and the resulting implications for the development of novel therapeutic approaches to prevent muscle loss. PMID:26793123

  3. Quality Control of Diffusion Weighted Images

    PubMed Central

    Liu, Zhexing; Wang, Yi; Gerig, Guido; Gouttard, Sylvain; Tao, Ran; Fletcher, Thomas; Styner, Martin

    2013-01-01

    Diffusion Tensor Imaging (DTI) has become an important MRI procedure to investigate the integrity of white matter in brain in vivo. DTI is estimated from a series of acquired Diffusion Weighted Imaging (DWI) volumes. DWI data suffers from inherent low SNR, overall long scanning time of multiple directional encoding with correspondingly large risk to encounter several kinds of artifacts. These artifacts can be too severe for a correct and stable estimation of the diffusion tensor. Thus, a quality control (QC) procedure is absolutely necessary for DTI studies. Currently, routine DTI QC procedures are conducted manually by visually checking the DWI data set in a gradient by gradient and slice by slice way. The results often suffer from low consistence across different data sets, lack of agreement of different experts, and difficulty to judge motion artifacts by qualitative inspection. Additionally considerable manpower is needed for this step due to the large number of images to QC, which is common for group comparison and longitudinal studies, especially with increasing number of diffusion gradient directions. We present a framework for automatic DWI QC. We developed a tool called DTIPrep which pipelines the QC steps with a detailed protocoling and reporting facility. And it is fully open source. This framework/tool has been successfully applied to several DTI studies with several hundred DWIs in our lab as well as collaborating labs in Utah and Iowa. In our studies, the tool provides a crucial piece for robust DTI analysis in brain white matter study. PMID:24353379

  4. Handling Qualities of Model Reference Adaptive Controllers with Varying Complexity for Pitch-Roll Coupled Failures

    NASA Technical Reports Server (NTRS)

    Schaefer, Jacob; Hanson, Curt; Johnson, Marcus A.; Nguyen, Nhan

    2011-01-01

    Three model reference adaptive controllers (MRAC) with varying levels of complexity were evaluated on a high performance jet aircraft and compared along with a baseline nonlinear dynamic inversion controller. The handling qualities and performance of the controllers were examined during failure conditions that induce coupling between the pitch and roll axes. Results from flight tests showed with a roll to pitch input coupling failure, the handling qualities went from Level 2 with the baseline controller to Level 1 with the most complex MRAC tested. A failure scenario with the left stabilator frozen also showed improvement with the MRAC. Improvement in performance and handling qualities was generally seen as complexity was incrementally added; however, added complexity usually corresponds to increased verification and validation effort required for certification. The tradeoff between complexity and performance is thus important to a controls system designer when implementing an adaptive controller on an aircraft. This paper investigates this relation through flight testing of several controllers of vary complexity.

  5. Specifying and testing weld neck flanges for better quality

    SciTech Connect

    Weirich, A.B.

    1996-07-01

    Field failures and persistent defects have impelled users to demand improved reliability in weld neck flanges. This paper explains why and how to specify for better quality. The answers are straightforward: Specify clearly -- Quality begins with improved raw stock, is assured by good manufacturing practices, and is warranted by appropriate quality controls. Be reasonable, specifications must be commercially viable in today`s competitive environment. Inspect the merchandise: Quality cannot be assured without effective enforcement. To think otherwise is unrealistic, regardless how good the procurement specifications may be. Review purchasing policies: When suppliers of quality products are identified, restricted purchases should be instituted. Quicker deliveries and a reliable supply of good quality product are assured as manufacturers maintain upgraded inventories in anticipation of repeat business.

  6. Austrian Daily Climate Data Rescue and Quality Control

    NASA Astrophysics Data System (ADS)

    Jurkovic, A.; Lipa, W.; Adler, S.; Albenberger, J.; Lechner, W.; Swietli, R.; Vossberg, I.; Zehetner, S.

    2010-09-01

    Checked climate datasets are a "conditio sine qua non" for all projects that are relevant for environment and climate. In the framework of climate change studies and analysis it is essential to work with quality controlled and trustful data. Furthermore these datasets are used as input for various simulation models. In regard to investigations of extreme events, like strong precipitation periods, drought periods and similar ones we need climate data in high temporal resolution (at least in daily resolution). Because of the historical background - during Second World War the majority of our climate sheets were sent to Berlin, where the historical sheets were destroyed by a bomb attack and so important information got lost - only several climate sheets, mostly duplicates, before 1939 are available and stored in our climate data archive. In 1970 the Central Institute for Meteorology and Geodynamics in Vienna started a first attempt to digitize climate data by means of punch cards. With the introduction of a routinely climate data quality control in 1984 we can speak of high-class-checked daily data (finally checked data, quality flag 6). Our group is working on the processing of digitization and quality control of the historical data for the period 1872 to 1983 for 18 years. Since 2007 it was possible to intensify the work (processes) in the framework of an internal project, namely Austrian Climate Data Rescue and Quality Control. The aim of this initiative was - and still is - to supply daily data in an outstanding good and uniform quality. So this project is a kind of pre-project for all scientific projects which are working with daily data. In addition to routine quality checks (that are running since 1984) using the commercial Bull Software we are testing our data with additional open source software, namely ProClim.db. By the use of this spatial and statistical test procedure, the elements air temperature and precipitation - for several sites in Carinthia - could

  7. Should Achievement Tests Be Used To Judge School Quality?

    ERIC Educational Resources Information Center

    Bauer, Scott C.

    A study was conducted to provide empirical evidence to answer the question of whether student scores on standardized achievement tests represent reasonable measures of instructional quality. Using a research protocol designed by W. Popham and the local study directors, individual test items from a nationally marketed standardized achievement test…

  8. Approaches to quality management and accreditation in a genetic testing laboratory

    PubMed Central

    Berwouts, Sarah; Morris, Michael A; Dequeker, Elisabeth

    2010-01-01

    Medical laboratories, and specifically genetic testing laboratories, provide vital medical services to different clients: clinicians requesting a test, patients from whom the sample was collected, public health and medical-legal instances, referral laboratories and authoritative bodies. All expect results that are accurate and obtained in an efficient and effective manner, within a suitable time frame and at acceptable cost. There are different ways of achieving the end results, but compliance with International Organization for Standardization (ISO) 15189, the international standard for the accreditation of medical laboratories, is becoming progressively accepted as the optimal approach to assuring quality in medical testing. We present recommendations and strategies designed to aid genetic testing laboratories with the implementation of a quality management system, including key aspects such as document control, external quality assessment, internal quality control, internal audit, management review, validation, as well as managing the human side of change. The focus is on pragmatic approaches to attain the levels of quality management and quality assurance required for accreditation according to ISO 15189, within the context of genetic testing. Attention is also given to implementing efficient and effective quality improvement. PMID:20720559

  9. Approaches to quality management and accreditation in a genetic testing laboratory.

    PubMed

    Berwouts, Sarah; Morris, Michael A; Dequeker, Elisabeth

    2010-09-01

    Medical laboratories, and specifically genetic testing laboratories, provide vital medical services to different clients: clinicians requesting a test, patients from whom the sample was collected, public health and medical-legal instances, referral laboratories and authoritative bodies. All expect results that are accurate and obtained in an efficient and effective manner, within a suitable time frame and at acceptable cost. There are different ways of achieving the end results, but compliance with International Organization for Standardization (ISO) 15189, the international standard for the accreditation of medical laboratories, is becoming progressively accepted as the optimal approach to assuring quality in medical testing. We present recommendations and strategies designed to aid genetic testing laboratories with the implementation of a quality management system, including key aspects such as document control, external quality assessment, internal quality control, internal audit, management review, validation, as well as managing the human side of change. The focus is on pragmatic approaches to attain the levels of quality management and quality assurance required for accreditation according to ISO 15189, within the context of genetic testing. Attention is also given to implementing efficient and effective quality improvement. PMID:20720559

  10. 42 CFR 84.256 - Quality control requirements.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 1 2010-10-01 2010-10-01 false Quality control requirements. 84.256 Section 84.256... § 84.256 Quality control requirements. (a) In addition to the construction and performance requirements specified in §§ 84.251, 84.252, 84.253, 84.254, and 84.255, the quality control requirements in...

  11. 42 CFR 84.256 - Quality control requirements.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 1 2011-10-01 2011-10-01 false Quality control requirements. 84.256 Section 84.256... § 84.256 Quality control requirements. (a) In addition to the construction and performance requirements specified in §§ 84.251, 84.252, 84.253, 84.254, and 84.255, the quality control requirements in...

  12. TECHNICAL GUIDANCE DOCUMENT: QUALITY ASSURANCE AND QUALITY CONTROL FOR WASTE CONTAINMENT FACILITIES

    EPA Science Inventory

    This Technical Guidance Document provides comprehensive guidance on procedures for quality assurance and quality control for waste containment facilities. he document includes a discussion of principles and concepts, compacted soil liners, soil drainage systems, geosynthetic drai...

  13. TECHNICAL GUIDANCE DOCUMENT: QUALITY ASSURANCE AND QUALITY CONTROL FOR WASTE CONTAINMENT FACILITIES

    EPA Science Inventory

    This Technical Guidance Document provides comprehensive guidance on procedures for quality assurance and quality control for waste containment facilities. The document includes a discussion of principles and concepts, compacted soil liners, soil drainage systems, geosynthetic dr...

  14. New automated quality control of phenological data in Switzerland

    NASA Astrophysics Data System (ADS)

    Pietragalla, Barbara; Knechtl, Valentin; Sigg, Christian; Clot, Bernard

    2016-04-01

    Phenological observations are considered important indicators of climate change. Therefore, reliable data is a crucial requirement. In 2015 MeteoSwiss has developed an automated quality control for phenological data that runs weekly to check the incoming data. The aim is to detect implausible data. The implausible values are further examined manually. The Swiss Phenology Network, initiated in 1951, consists of about 160 stations observing 69 phenological parameters from 26 species. In 2015 the network generated 6475 values of onset dates. For the recognition of implausible data, linear models are used. For each of the phenological parameters that should be verified the most predictive parameters have been determined in correlation tests. Up to four different parameters are used as predictive variables. The three main predictive parameters are the mean onset date of the respective phenophase (at that specific station), the cumulated daily mean temperature and an additional phenological parameter with the highest correlation. The model uses a defined sequence of steps, which can handle the absence of additional predictive phenological parameters (in case that in spring time some of these phenophases are not yet available). The model output is a predicted date which can be compared with the observed onset date that undergoes the quality control. The magnitude of this deviation decides, if a value is regarded as potentially problematic. An additional quality check examines if the natural sequence of the phenophases within a species is correct, for example that the date of the "begin of flowering" occurs before the "full flowering". The output of the automated quality control is a list of flagged values of potentially erroneous data that have to be examined manually in a second step. To facilitate the expert's decision whether a value is correct or wrong, a report is automatically created, showing the data graphically and in comparison with other stations of the same

  15. Antimisting kerosene: Base fuel effects, blending and quality control techniques

    NASA Technical Reports Server (NTRS)

    Yavrouian, A. H.; Ernest, J.; Sarohia, V.

    1984-01-01

    The problems associated with blending of the AMK additive with Jet A, and the base fuel effects on AMK properties are addressed. The results from the evaluation of some of the quality control techniques for AMK are presented. The principal conclusions of this investigation are: significant compositional differences for base fuel (Jet A) within the ASTM specification DI655; higher aromatic content of the base fuel was found to be beneficial for the polymer dissolution at ambient (20 C) temperature; using static mixer technology, the antimisting additive (FM-9) is in-line blended with Jet A, producing AMK which has adequate fire-protection properties 15 to 20 minutes after blending; degradability of freshly blended and equilibrated AMK indicated that maximum degradability is reached after adequate fire protection is obtained; the results of AMK degradability as measured by filter ratio, confirmed previous RAE data that power requirements to decade freshly blended AMK are significantly higher than equilibrated AMK; blending of the additive by using FM-9 concentrate in Jet A produces equilibrated AMK almost instantly; nephelometry offers a simple continuous monitoring capability and is used as a real time quality control device for AMK; and trajectory (jet thurst) and pressure drop tests are useful laboratory techniques for evaluating AMK quality.

  16. Digital intraoral radiographic quality assurance and control in private practice.

    PubMed

    Walker, Timothy F; Mah, Peter; Dove, S Brent; McDavid, W Doss

    2014-01-01

    At present, the American Dental Association and the American Academy of Oral Maxillofacial Radiology have guidelines for the dental environment that include quality assurance and control of film-based radiography. Approximately 19%-30% of US dental offices currently use some form of digital intraoral radiography, and growth is expected to continue. It is anticipated that new tools and guidelines will be needed to aid in the development of quality assurance (QA) and control of digital intraoral radiographic images. Working with a representative sample of private practice dental offices, this study examined and evaluated the entire digital intraoral radiographic system used in each operatory. The X-ray machine was tested for equipment performance and accuracy, and the computer monitor calibration was evaluated and adjusted as needed. The results confirm the continued need for updated QA procedures in the dental office that include digital X-ray imaging. By implementing these changes and practices, dentists should be able to improve the diagnostic quality of radiographs while reducing the radiation exposure of the patient. PMID:25184710

  17. Proteomics Quality Control: Quality Control Software for MaxQuant Results.

    PubMed

    Bielow, Chris; Mastrobuoni, Guido; Kempa, Stefan

    2016-03-01

    Mass spectrometry-based proteomics coupled to liquid chromatography has matured into an automatized, high-throughput technology, producing data on the scale of multiple gigabytes per instrument per day. Consequently, an automated quality control (QC) and quality analysis (QA) capable of detecting measurement bias, verifying consistency, and avoiding propagation of error is paramount for instrument operators and scientists in charge of downstream analysis. We have developed an R-based QC pipeline called Proteomics Quality Control (PTXQC) for bottom-up LC-MS data generated by the MaxQuant1 software pipeline. PTXQC creates a QC report containing a comprehensive and powerful set of QC metrics, augmented with automated scoring functions. The automated scores are collated to create an overview heatmap at the beginning of the report, giving valuable guidance also to nonspecialists. Our software supports a wide range of experimental designs, including stable isotope labeling by amino acids in cell culture (SILAC), tandem mass tags (TMT), and label-free data. Furthermore, we introduce new metrics to score MaxQuant's Match-between-runs (MBR) functionality by which peptide identifications can be transferred across Raw files based on accurate retention time and m/z. Last but not least, PTXQC is easy to install and use and represents the first QC software capable of processing MaxQuant result tables. PTXQC is freely available at https://github.com/cbielow/PTXQC . PMID:26653327

  18. Computerized Numerical Control Test Item Bank.

    ERIC Educational Resources Information Center

    Reneau, Fred; And Others

    This guide contains 285 test items for use in teaching a course in computerized numerical control. All test items were reviewed, revised, and validated by incumbent workers and subject matter instructors. Items are provided for assessing student achievement in such aspects of programming and planning, setting up, and operating machines with…

  19. TOXIC SUBSTANCES CONTROL ACT TEST SUBMISSIONS (TSCATS)

    EPA Science Inventory

    Toxic Substances Control Act Test Submissions (TSCATS) is an online index to unpublished, nonconfidential studies covering chemical testing results and adverse effects of chemicals on health and ecological systems. The studies are submitted by U.S. industry to EPA under several s...

  20. The BNL Accelerator Test Facility control system

    SciTech Connect

    Malone, R.; Bottke, I.; Fernow, R.; Ben-Zvi, I.

    1993-01-01

    Described is the VAX/CAMAC-based control system for Brookhaven National Laboratory's Accelerator Test Facility, a laser/linac research complex. Details of hardware and software configurations are presented along with experiences of using Vsystem, a commercial control system package.

  1. Dynamic assertion testing of flight control software

    NASA Technical Reports Server (NTRS)

    Andrews, D. M.; Mahmood, A.; Mccluskey, E. J.

    1985-01-01

    Digital Flight Control System (DFCS) software was used as a test case for assertion testing. The assertions were written and embedded in the code, then errors were inserted (seeded) one at a time and the code executed. Results indicate that assertion testing is an effective and efficient method of detecting errors in flight software. Most errors are eliminate at an earlier stage in the development than before.

  2. International Quality Control Is No Easy Task

    ERIC Educational Resources Information Center

    Contreras, Alan

    2008-01-01

    In early March, the European Quality Assurance Register for Higher Education was established under what is called the Bologna Process. The 46 countries involved in the process seek to improve the quality and assessment of higher education throughout Europe, thus facilitating students' mobility among institutions and countries and enhancing…

  3. Technology to control variation in meat quality

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Consumers have certain expectations regarding the quality of the meat they purchase. Lean color is the primary quality attribute used by consumers to make purchase decisions. Similarly, repeat purchase decisions are generally a result of eating satisfaction, which is determined by the perceived va...

  4. Flight test of a displacement sidearm controller

    NASA Technical Reports Server (NTRS)

    Lippay, A. L.; Kruk, R.; King, M.; Morgan, M.

    1986-01-01

    A six-axis displacement-stick sidearm controller was developed to enable single-handed control of remote manipulator operations in space. With a working model available, piloted evaluation became possible in a fly-by-computer variable-stability research aircraft, originally a Bell 205 helicopter. The original mechanization was limited to three rotational axes and a linear one, analogous to the collective stick. A newly designed short stickgrip was mounted and the spring force pattern adjusted to suit the helicopter flight control environment. A standard set of test maneuvers was flown by four experimental pilots with conventional helicopter flight controls and with sidearm controllers equipped with two different handgrips. Existing data from flight tests with an isometric-stick controller were added to complete the comparison. The displacement controller consistently achieved a rating of 3.0 to 3.5 on the Cooper-Harper scale, on par with the conventional controls. The same basic controller design was tested in spacecraft and remote manipulator simulations with very promising results. In each application operator/system integration was rapid and positive. The results demonstrate feasibility and support the design philosphy of using deflection as well as force to generate proprioceptive feedback.

  5. Digital reconstructed radiography quality control with software methods

    NASA Astrophysics Data System (ADS)

    Denis, Eloise; Beaumont, Stephane; Guedon, JeanPierre

    2005-04-01

    Nowadays, most of treatments for external radiotherapy are prepared with Treatment Planning Systems (TPS) which uses a virtual patient generated by a set of transverse slices acquired with a CT scanner of the patient in treatment position 1 2 3. In the first step of virtual simulation, the TPS is used to define a ballistic allowing a good target covering and the lowest irradiation for normal tissues. This parameters optimisation of the treatment with the TPS is realised with particular graphic tools allowing to: ×Contour the target, ×Expand the limit of the target in order to take into account contouring uncertainties, patient set up errors, movements of the target during the treatment (internal movement of the target and external movement of the patient), and beam's penumbra, ×Determine beams orientation and define dimensions and forms of the beams, ×Visualize beams on the patient's skin and calculate some characteristic points which will be tattooed on the patient to assist the patient set up before treating, ×Calculate for each beam a Digital Reconstructed Radiography (DRR) consisting in projecting the 3D CT virtual patient and beam limits with a cone beam geometry onto a plane. These DRR allow one for insuring the patient positioning during the treatment, essentially bone structures alignment by comparison with real radiography realized with the treatment X-ray source in the same geometric conditions (portal imaging). Then DRR are preponderant to insure the geometric accuracy of the treatment. For this reason quality control of its computation is mandatory4 . Until now, this control is realised with real test objects including some special inclusions4 5 . This paper proposes to use some numerical test objects to control the quality DRR calculation in terms of computation time, beam angle, divergence and magnification precision, spatial and contrast resolutions. The main advantage of this proposed method is to avoid a real test object CT acquisition

  6. Foodborne Listeria monocytogenes: A Real Challenge in Quality Control.

    PubMed

    Pusztahelyi, Tünde; Szabó, Judit; Dombrádi, Zsuzsanna; Kovács, Szilvia; Pócsi, István

    2016-01-01

    Listeria monocytogenes is a foodborne pathogen, and the detection and differentiation of this bacterium from the nonpathogenic Listeria species are of great importance to the food industry. Differentiation of Listeria species is very difficult, even with the sophisticated MALDI-TOF MS technique because of the close genetic relationship of the species and the usual gene transfer. The present paper emphasizes the difficulties of the differentiation through the standardized detection and confirmation according to ISO 11290-1:1996 and basic available L. monocytogenes detection methods and tests (such as API Listeria test, MALDI-TOF MS analysis, and hly gene PCR). With the increase of reports on the pathogenesis of atypical Listeria strains in humans, the significance of species level determination has become questionable, especially in food quality control, and the detection of pathogenic characteristics seems to be more relevant. PMID:27239376

  7. Foodborne Listeria monocytogenes: A Real Challenge in Quality Control

    PubMed Central

    Pusztahelyi, Tünde; Szabó, Judit; Dombrádi, Zsuzsanna; Kovács, Szilvia; Pócsi, István

    2016-01-01

    Listeria monocytogenes is a foodborne pathogen, and the detection and differentiation of this bacterium from the nonpathogenic Listeria species are of great importance to the food industry. Differentiation of Listeria species is very difficult, even with the sophisticated MALDI-TOF MS technique because of the close genetic relationship of the species and the usual gene transfer. The present paper emphasizes the difficulties of the differentiation through the standardized detection and confirmation according to ISO 11290-1:1996 and basic available L. monocytogenes detection methods and tests (such as API Listeria test, MALDI-TOF MS analysis, and hly gene PCR). With the increase of reports on the pathogenesis of atypical Listeria strains in humans, the significance of species level determination has become questionable, especially in food quality control, and the detection of pathogenic characteristics seems to be more relevant. PMID:27239376

  8. 42 CFR 84.41 - Quality control plans; contents.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... management of quality, including: (1) Requirements for the production of quality data and the use of quality... accordance with 5 U.S.C. 552(a) and 1 CFR part 51. Copies may be obtained from DODSSP, Standardization..., manufacturing, and fabrication, inspections are adequate to ensure control of finished article...

  9. 42 CFR 84.41 - Quality control plans; contents.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... management of quality, including: (1) Requirements for the production of quality data and the use of quality... accordance with 5 U.S.C. 552(a) and 1 CFR part 51. Copies may be obtained from DODSSP, Standardization..., manufacturing, and fabrication, inspections are adequate to ensure control of finished article...

  10. 42 CFR 84.41 - Quality control plans; contents.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... management of quality, including: (1) Requirements for the production of quality data and the use of quality... accordance with 5 U.S.C. 552(a) and 1 CFR part 51. Copies may be obtained from DODSSP, Standardization..., manufacturing, and fabrication, inspections are adequate to ensure control of finished article...

  11. 42 CFR 84.41 - Quality control plans; contents.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... management of quality, including: (1) Requirements for the production of quality data and the use of quality... accordance with 5 U.S.C. 552(a) and 1 CFR part 51. Copies may be obtained from DODSSP, Standardization..., manufacturing, and fabrication, inspections are adequate to ensure control of finished article...

  12. Integrated Quality Control Measurement Project. Findings and Corrective Actions.

    ERIC Educational Resources Information Center

    Price Waterhouse and Co., New York, NY.

    The Integrated Quality Control Measurement Project (IQCMP) of the U.S. Department of Education measured the quality of awards distributed during the 1988-89 award year under the three major Title IV programs: the Pell Grant program, the Campus-Based programs, and the Stafford Loan program, in order to evaluate and improve the quality of the…

  13. Food and Nutrition Services Quality Control Management Program.

    ERIC Educational Resources Information Center

    Wimsatt-Fraim, Teresa S.

    A program was conducted to improve the quality of food service through the training of 44 food and nutrition service employees in a 200-bed hospital. A 12-week quality control program was implemented to address four key areas: food temperatures, food accuracy, food quality, and dietary personnel. Learning strategies, emphasizing critical thinking…

  14. A Systems Engineering Approach to Quality Assurance for Aerospace Testing

    NASA Technical Reports Server (NTRS)

    Shepherd, Christena C.

    2014-01-01

    On the surface, it appears that AS9100 has little to say about how to apply a Quality Management System (QMS) to major aerospace test programs (or even smaller ones). It also appears that there is little in the quality engineering Body of Knowledge (BOK) that applies to testing, unless it is nondestructive examination (NDE), or some type of lab or bench testing associated with the manufacturing process. However, if one examines: a) how the systems engineering (SE) processes are implemented throughout a test program; and b) how these SE processes can be mapped to the requirements of AS9100, a number of areas for involvement of the quality professional are revealed. What often happens is that quality assurance during a test program is limited to inspections of the test article; what could be considered a manufacturing al fresco approach. This limits the quality professional and is a disservice to the programs and projects, since there are a number of ways that quality can enhance critical processes, and support efforts to improve risk reduction, efficiency and effectiveness. The Systems Engineering (SE) discipline is widely used in aerospace to ensure the progress from Stakeholder Expectations (the President, Congress, the taxpayers) to a successful, delivered product or service. Although this is well known, what is not well known is that these same SE processes are implemented in varying complexity, to prepare for and implement test projects that support research, development, verification and validation, qualification, and acceptance test projects. Although the test organization's terminology may vary from the SE terminology, and from one test service provider to another, the basic process is followed by successful, reliable testing organizations. For this analysis, NASA Procedural Requirements (NPR) 7123.1, NASA Systems Engineering Processes and Requirements is used to illustrate the SE processes that are used for major aerospace testing. Many of these processes

  15. Non-Destructive Testing for Control of Radioactive Waste Package

    NASA Astrophysics Data System (ADS)

    Plumeri, S.; Carrel, F.

    2015-10-01

    Characterization and control of radioactive waste packages are important issues in the management of a radioactive waste repository. Therefore, Andra performs quality control inspection on radwaste package before disposal to ensure the compliance of the radwast characteristics with Andra waste disposal specifications and to check the consistency between Andra measurements results and producer declared properties. Objectives of this quality control are: assessment and improvement of producer radwaste packages quality mastery, guarantee of the radwaste disposal safety, maintain of the public confidence. To control radiological characteristics of radwaste package, non-destructive passive methods (gamma spectrometry and neutrons counting) are commonly used. These passive methods may not be sufficient, for instance to control the mass of fissile material contained inside radwaste package. This is particularly true for large concrete hull of heterogeneous radwaste containing several actinides mixed with fission products like 137Cs. Non-destructive active methods, like measurement of photofission delayed neutrons, allow to quantify the global mass of actinides and is a promising method to quantify mass of fissile material. Andra has performed different non-destructive measurements on concrete intermediate-level short lived nuclear waste (ILW-SL) package to control its nuclear material content. These tests have allowed Andra to have a first evaluation of the performance of photofission delayed neutron measurement and to identify development needed to have a reliable method, especially for fissile material mass control in intermediate-level long lived waste package.

  16. 10 CFR 26.137 - Quality assurance and quality control.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... concentrations equal to or greater than a 50 mcg/mL chromium(VI)-equivalent cutoff, and/or a halogen screening test must be able to determine the halogen concentration is equal to or greater than the LOD. Licensees...; or halogen samples formulated in a concentration at or near the LOD and 25 percent above the LOD....

  17. 10 CFR 26.137 - Quality assurance and quality control.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... concentrations equal to or greater than a 50 mcg/mL chromium(VI)-equivalent cutoff, and/or a halogen screening test must be able to determine the halogen concentration is equal to or greater than the LOD. Licensees...; or halogen samples formulated in a concentration at or near the LOD and 25 percent above the LOD....

  18. 10 CFR 26.167 - Quality assurance and quality control.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... decimal places, and must be interfaced with a laboratory information management system, or computer, and... document the linearity of the assay method over time in the concentration area of the cutoff (after..., substituted, dilute, or invalid in validity testing, from the time of final resolution of the error back...

  19. Servo-controlled biaxial test system

    SciTech Connect

    Thayer, W.L.

    1983-02-11

    A large test program requiring axial torsion tests was submitted to the Materials Test and Evaluation Section of the Engineering Sciences Division by the Chemistry Department. The objective of these tests was to provide insight with regard to the fundamental aspects of plastic deformation and hardening of nickel. Thes tests will also provide the constants necessary for a constitutive equation for use in weld modeling. The weld models will attempt to predict residual stresses in nickel welds. The test program consisted of approximately 70 specimens of high purity nickel to be tested in torsion over a large temperature range (RT - 900/sup 0/C) at a strain rate of about 1 x 10/sup -4/ in./in./sec to steady state at each temperature. After having attained steady state, the strain-rate-reversal (Bauschinger test) and incremental-changes-in-strain-rate tests (10/sup -4/ to 2 x 10/sup -3/ in./in./sec) at constant structure will be conducted. Additional tests such as transient backstress and yield surface distortion (using multi-axial stress states) will be carried out. This particular request required a biaxial test machine capable of more than 360/sup 0/ rotation in torsion. Temperature capabilities, atmosphere control, and a control system were also needed whereby the machine could be operated in torsion using strain control. Such a machine did not commercially exist so it was necessary to build one. The basic unit chosen was a 20K Servo-Electric Hydraulic Test Machine to which we added a simple anti-rotation fixture for the ram. This constituted the axial portion of the system.

  20. Teaching Quality Control with Chocolate Chip Cookies

    ERIC Educational Resources Information Center

    Baker, Ardith

    2014-01-01

    Chocolate chip cookies are used to illustrate the importance and effectiveness of control charts in Statistical Process Control. By counting the number of chocolate chips, creating the spreadsheet, calculating the control limits and graphing the control charts, the student becomes actively engaged in the learning process. In addition, examining…

  1. Space Shuttle flying qualities and flight control system assessment study

    NASA Technical Reports Server (NTRS)

    Myers, T. T.; Johnston, D. E.; Mcruer, D.

    1982-01-01

    The suitability of existing and proposed flying quality and flight control system criteria for application to the space shuttle orbiter during atmospheric flight phases was assessed. An orbiter experiment for flying qualities and flight control system design criteria is discussed. Orbiter longitudinal and lateral-directional flying characteristics, flight control system lag and time delay considerations, and flight control manipulator characteristics are included. Data obtained from conventional aircraft may be inappropriate for application to the shuttle orbiter.

  2. Real-time control of combined surface water quantity and quality: polder flushing.

    PubMed

    Xu, M; van Overloop, P J; van de Giesen, N C; Stelling, G S

    2010-01-01

    In open water systems, keeping both water depths and water quality at specified values is critical for maintaining a 'healthy' water system. Many systems still require manual operation, at least for water quality management. When applying real-time control, both quantity and quality standards need to be met. In this paper, an artificial polder flushing case is studied. Model Predictive Control (MPC) is developed to control the system. In addition to MPC, a 'forward estimation' procedure is used to acquire water quality predictions for the simplified model used in MPC optimization. In order to illustrate the advantages of MPC, classical control [Proportional-Integral control (PI)] has been developed for comparison in the test case. The results show that both algorithms are able to control the polder flushing process, but MPC is more efficient in functionality and control flexibility. PMID:20182064

  3. 46 CFR 164.019-13 - Production quality control requirements.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 6 2012-10-01 2012-10-01 false Production quality control requirements. 164.019-13 Section 164.019-13 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) EQUIPMENT, CONSTRUCTION, AND MATERIALS: SPECIFICATIONS AND APPROVAL MATERIALS Personal Flotation Device Components § 164.019-13 Production quality control...

  4. 14 CFR 145.211 - Quality control system.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ...) SCHOOLS AND OTHER CERTIFICATED AGENCIES REPAIR STATIONS Operating Rules § 145.211 Quality control system. (a) A certificated repair station must establish and maintain a quality control system acceptable to the FAA that ensures the airworthiness of the articles on which the repair station or any of...

  5. 14 CFR 145.211 - Quality control system.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ...) SCHOOLS AND OTHER CERTIFICATED AGENCIES REPAIR STATIONS Operating Rules § 145.211 Quality control system. (a) A certificated repair station must establish and maintain a quality control system acceptable to the FAA that ensures the airworthiness of the articles on which the repair station or any of...

  6. 14 CFR 145.211 - Quality control system.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ...) SCHOOLS AND OTHER CERTIFICATED AGENCIES REPAIR STATIONS Operating Rules § 145.211 Quality control system. (a) A certificated repair station must establish and maintain a quality control system acceptable to the FAA that ensures the airworthiness of the articles on which the repair station or any of...

  7. Quality Control Study of the GSL Reinsurance System. Final Report.

    ERIC Educational Resources Information Center

    Advanced Technology, Inc., Reston, VA.

    A quality control plan for the U.S. Department of Education's Guaranteed Student Loan (GSL) reinsurance process was developed. To identify existing errors, systems documentation and past analyses of the reinsurance system were analyzed, and interviews were conducted. Corrective actions were proposed, and a quality control checklist was developed…

  8. Building Science Corporation's Building America Quality Control Checklist

    SciTech Connect

    2008-10-05

    The Building America Quality Control Checklist has been developed as both a guide to assist in the transition to high performance home building, and as a simplified tool to be used as part of any builder's on-site quality control procedures.

  9. Artificial Intelligence Approach to Support Statistical Quality Control Teaching

    ERIC Educational Resources Information Center

    Reis, Marcelo Menezes; Paladini, Edson Pacheco; Khator, Suresh; Sommer, Willy Arno

    2006-01-01

    Statistical quality control--SQC (consisting of Statistical Process Control, Process Capability Studies, Acceptance Sampling and Design of Experiments) is a very important tool to obtain, maintain and improve the Quality level of goods and services produced by an organization. Despite its importance, and the fact that it is taught in technical and…

  10. Unit testing-based approach for reconfigurable logic controllers verification

    NASA Astrophysics Data System (ADS)

    Doligalski, Michał; Tkacz, Jacek; Bukowiec, Arkadiusz; Gratkowski, Tomasz

    2015-09-01

    The paper presents unit testing-based approach to FPGA design in-circuit verification. Presented methodology is dedicated to modular reconfigurable logic controllers, but other ip-cores and systems can be verified as well. The speed and reproducibility of tests is key for rapid system prototyping, where the quality and reliability of the system is significance. Typically FPGA are programmed by means single (full) bitstream. Specific devices are able to be reconfigured partially. Usually the partial reconfiguration is a part of the design functionality. It enables the minimization of used resources or provides specific functionality like system adaptation. The paper presents the use of the partial reconfiguration as a toll for the designer. The unit testing approach well know form software engineering was adopted to modular logic controllers development. The simulation process results waveform files, the waveform can be used for synthesizable test bench generation.

  11. For and against a European quality control of training.

    PubMed

    Dimitrakakis, C; Michalas, S

    2001-01-01

    In a world of medicine that evolves more and more rapidly, sufficient quality of education in the arts and crafts of our discipline and control of this quality are essential for the progress and vitality of Ob/Gyn. There are variations in training within European countries but with the aim of harmonization in training programmes and the flexibility of quality control mechanisms we will meet our objective that is the high standards in the care of woman throughout Europe. PMID:11205701

  12. Flight Test of an Intelligent Flight-Control System

    NASA Technical Reports Server (NTRS)

    Davidson, Ron; Bosworth, John T.; Jacobson, Steven R.; Thomson, Michael Pl; Jorgensen, Charles C.

    2003-01-01

    inputs with the outputs provided to instrumentation only. The IFCS was not used to control the airplane. In another stage of the flight test, the Phase I pre-trained neural network was integrated into a Phase III version of the flight control system. The Phase I pretrained neural network provided realtime stability and control derivatives to a Phase III controller that was based on a stochastic optimal feedforward and feedback technique (SOFFT). This combined Phase I/III system was operated together with the research flight-control system (RFCS) of the F-15 ACTIVE during the flight test. The RFCS enables the pilot to switch quickly from the experimental- research flight mode back to the safe conventional mode. These initial IFCS ACP flight tests were completed in April 1999. The Phase I/III flight test milestone was to demonstrate, across a range of subsonic and supersonic flight conditions, that the pre-trained neural network could be used to supply real-time aerodynamic stability and control derivatives to the closed-loop optimal SOFFT flight controller. Additional objectives attained in the flight test included (1) flight qualification of a neural-network-based control system; (2) the use of a combined neural-network/closed-loop optimal flight-control system to obtain level-one handling qualities; and (3) demonstration, through variation of control gains, that different handling qualities can be achieved by setting new target parameters. In addition, data for the Phase-II (on-line-learning) neural network were collected, during the use of stacked-frequency- sweep excitation, for post-flight analysis. Initial analysis of these data showed the potential for future flight tests that will incorporate the real-time identification and on-line learning aspects of the IFCS.

  13. Water Quality: A Field-Based Quality Testing Program for Middle Schools and High Schools.

    ERIC Educational Resources Information Center

    Massachusetts State Water Resources Authority, Boston.

    This manual contains background information, lesson ideas, procedures, data collection and reporting forms, suggestions for interpreting results, and extension activities to complement a water quality field testing program. Information on testing water temperature, water pH, dissolved oxygen content, biochemical oxygen demand, nitrates, total…

  14. Quality control considerations in performing washability analyses

    SciTech Connect

    Graham, R.D.

    1984-10-01

    The author describes, in considerable detail, the procedures for carrying out washability analyses as laid down in ASTM Standard Test Method D4371. These include sampling, sample preparation, hydrometer standardisation, washability testing, and analysis of specific gravity fractions.

  15. 40 CFR Appendix B to Part 75 - Quality Assurance and Quality Control Procedures

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 17 2013-07-01 2013-07-01 false Quality Assurance and Quality Control Procedures B Appendix B to Part 75 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) CONTINUOUS EMISSION MONITORING Pt. 75, App. B Appendix B to Part 75—Quality...

  16. Data-Logger Interface And Test Controller

    NASA Technical Reports Server (NTRS)

    Burch, Donnie R.

    1995-01-01

    Data-logger interface and test controller developed to enable automation of tests in conjunction with data-acquisition functions performed by data loggers that have output-switching capabilities. Includes relay logic circuits that remain deenergized until out-of-tolerance condition on any data channel discovered. Designed to be connected to Fluke model 2286A (or equivalent) data-logger system, which features 3 control channels with 6 data inputs per channel. Includes elapsed-time counter that keeps track of power outages.

  17. Quality Assurance Project Plan for the Gas Generation Testing Program at the INEL

    SciTech Connect

    1994-10-01

    The data quality objectives (DQOs) for the Program are to evaluate compliance with the limits on total gas generation rates, establish the concentrations of hydrogen and methane in the total gas flow, determine the headspace concentration of VOCs in each drum prior to the start of the test, and obtain estimates of the concentrations of several compounds for mass balance purposes. Criteria for the selection of waste containers at the INEL and the parameters that must be characterized prior to and during the tests are described. Collection of gaseous samples from 55-gallon drums of contact-handled transuranic waste for the gas generation testing is discussed. Analytical methods and calibrations are summarized. Administrative quality control measures described in this QAPjP include the generation, review, and approval of project documentation; control and retention of records; measures to ensure that personnel, subcontractors or vendors, and equipment meet the specifications necessary to achieve the required data quality for the project.

  18. Higher quality of molecular testing, an unfulfilled priority: Results from external quality assessment for KRAS mutation testing in colorectal cancer.

    PubMed

    Tembuyser, Lien; Ligtenberg, Marjolijn J L; Normanno, Nicola; Delen, Sofie; van Krieken, J Han; Dequeker, Elisabeth M C

    2014-05-01

    Precision medicine is now a key element in clinical oncology. RAS mutational status is a crucial predictor of responsiveness to anti-epidermal growth factor receptor agents in metastatic colorectal cancer. In an effort to guarantee high-quality testing services in molecular pathology, the European Society of Pathology has been organizing an annual KRAS external quality assessment program since 2009. In 2012, 10 formalin-fixed, paraffin-embedded samples, of which 8 from invasive metastatic colorectal cancer tissue and 2 artificial samples of cell line material, were sent to more than 100 laboratories from 26 countries with a request for routine KRAS testing. Both genotyping and clinical reports were assessed independently. Twenty-seven percent of the participants genotyped at least 1 of 10 samples incorrectly. In total, less than 5% of the distributed specimens were genotyped incorrectly. Genotyping errors consisted of false negatives, false positives, and incorrectly genotyped mutations. Twenty percent of the laboratories reported a technical error for one or more samples. A review of the written reports showed that several essential elements were missing, most notably a clinical interpretation of the test result, the method sensitivity, and the use of a reference sequence. External quality assessment serves as a valuable educational tool in assessing and improving molecular testing quality and is an important asset for monitoring quality assurance upon incorporation of new biomarkers in diagnostic services. PMID:24631467

  19. 40 CFR 75.59 - Certification, quality assurance, and quality control record provisions.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... paragraphs (a)(7)(iv)(B) through (I) and (L) through (O); and (G) Stack gas density adjustment factor (if... density. (11) For each other quality-assurance test or other quality assurance activity, the owner or.... (3) For each visual inspection of the primary element or transmitter or transducer accuracy test...

  20. Improving the quality of parameter estimates obtained from slug tests

    USGS Publications Warehouse

    Butler, J.J., Jr.; McElwee, C.D.; Liu, W.

    1996-01-01

    The slug test is one of the most commonly used field methods for obtaining in situ estimates of hydraulic conductivity. Despite its prevalence, this method has received criticism from many quarters in the ground-water community. This criticism emphasizes the poor quality of the estimated parameters, a condition that is primarily a product of the somewhat casual approach that is often employed in slug tests. Recently, the Kansas Geological Survey (KGS) has pursued research directed it improving methods for the performance and analysis of slug tests. Based on extensive theoretical and field research, a series of guidelines have been proposed that should enable the quality of parameter estimates to be improved. The most significant of these guidelines are: (1) three or more slug tests should be performed at each well during a given test period; (2) two or more different initial displacements (Ho) should be used at each well during a test period; (3) the method used to initiate a test should enable the slug to be introduced in a near-instantaneous manner and should allow a good estimate of Ho to be obtained; (4) data-acquisition equipment that enables a large quantity of high quality data to be collected should be employed; (5) if an estimate of the storage parameter is needed, an observation well other than the test well should be employed; (6) the method chosen for analysis of the slug-test data should be appropriate for site conditions; (7) use of pre- and post-analysis plots should be an integral component of the analysis procedure, and (8) appropriate well construction parameters should be employed. Data from slug tests performed at a number of KGS field sites demonstrate the importance of these guidelines.

  1. Ride quality sensitivity to SAS control law and to handling quality variations

    NASA Technical Reports Server (NTRS)

    Roberts, P. A.; Schmidt, D. K.; Swaim, R. L.

    1976-01-01

    The RQ trends which large flexible aircraft exhibit under various parameterizations of control laws and handling qualities are discussed. A summary of the assumptions and solution technique, a control law parameterization review, a discussion of ride sensitivity to handling qualities, and the RQ effects generated by implementing relaxed static stability configurations are included.

  2. Early experience with automated B-mode quality assurance tests

    PubMed Central

    Gibson, NM

    2013-01-01

    Although quality assurance programmes have been recommended for many years, there is limited evidence of their efficacy. This study aimed to assess whether an automated image quality analysis method could demonstrate changes in scanner performance in a quality assurance programme. Test object images were analysed, measuring lateral resolution, low contrast penetration, slice thickness, anechoic target visibility and grey-scale target contrast and visibility. Known and suspected scanner faults were investigated and routine results were reviewed. At least one variable changed in response to each known or suspected scanner fault. Resolution and grey-scale target visibility changed due to image shadowing. Slice thickness, lateral resolution and grey-scale target contrast were affected where users reported deterioration in image quality. A single probe fell out of tolerance on routine testing, due to an unrecorded change to the default preset by the supplier’s representative. Interpretation of individual results is not always intuitive, observed changes depending on the shape of the grey-scale transfer curve and on target and background echo levels. Our results have provided evidence for the efficacy of this method of performance testing. Further experience is required to evaluate this method for prospective detection of faults and further work is required to determine optimum scanner settings and test object properties to maximise fault detection and to reduce the dependence of results on confounding factors.

  3. Portable Imagery Quality Assessment Test Field for Uav Sensors

    NASA Astrophysics Data System (ADS)

    Dąbrowski, R.; Jenerowicz, A.

    2015-08-01

    Nowadays the imagery data acquired from UAV sensors are the main source of all data used in various remote sensing applications, photogrammetry projects and in imagery intelligence (IMINT) as well as in other tasks as decision support. Therefore quality assessment of such imagery is an important task. The research team from Military University of Technology, Faculty of Civil Engineering and Geodesy, Geodesy Institute, Department of Remote Sensing and Photogrammetry has designed and prepared special test field- The Portable Imagery Quality Assessment Test Field (PIQuAT) that provides quality assessment in field conditions of images obtained with sensors mounted on UAVs. The PIQuAT consists of 6 individual segments, when combined allow for determine radiometric, spectral and spatial resolution of images acquired from UAVs. All segments of the PIQuAT can be used together in various configurations or independently. All elements of The Portable Imagery Quality Assessment Test Field were tested in laboratory conditions in terms of their radiometry and spectral reflectance characteristics.

  4. Statistical Quality Control of Moisture Data in GEOS DAS

    NASA Technical Reports Server (NTRS)

    Dee, D. P.; Rukhovets, L.; Todling, R.

    1999-01-01

    A new statistical quality control algorithm was recently implemented in the Goddard Earth Observing System Data Assimilation System (GEOS DAS). The final step in the algorithm consists of an adaptive buddy check that either accepts or rejects outlier observations based on a local statistical analysis of nearby data. A basic assumption in any such test is that the observed field is spatially coherent, in the sense that nearby data can be expected to confirm each other. However, the buddy check resulted in excessive rejection of moisture data, especially during the Northern Hemisphere summer. The analysis moisture variable in GEOS DAS is water vapor mixing ratio. Observational evidence shows that the distribution of mixing ratio errors is far from normal. Furthermore, spatial correlations among mixing ratio errors are highly anisotropic and difficult to identify. Both factors contribute to the poor performance of the statistical quality control algorithm. To alleviate the problem, we applied the buddy check to relative humidity data instead. This variable explicitly depends on temperature and therefore exhibits a much greater spatial coherence. As a result, reject rates of moisture data are much more reasonable and homogeneous in time and space.

  5. RECEIVING WATER QUALITY DATABASE FOR TESTING OF MATHEMATICAL MODELS

    EPA Science Inventory

    Many mathematical models exist for simulation of quantity and quality parameters of receiving waters. Such models are frequently used in the evaluation of effects on receiving waters of pollution control alternatives such as advanced waste treatment and nonpoint source runoff aba...

  6. Test patterns and quality metrics for digital video compression

    NASA Astrophysics Data System (ADS)

    Fenimore, Charles P.; Field, Bruce F.; Van Degrift, Craig

    1997-06-01

    Lossy video compression systems such as MPEG2 introduce picture impairments such as image blocking, color distortion and persistent color fragments, 'mosquito noise,' and blurring in their outputs. While there are video test clips which exhibit one or more of these distortions upon coding, there is need of a set of well-characterized test patterns and video quality metrics. Digital test patterns can deliver calibrated stresses to specific features of the encoder, much as the test patterns for analog video stress critical characteristics of that system. Metrics quantify the error effects of compression by a computation. NIST is developing such test patterns and metrics for compression rates that typically introduce perceptually negligible artifacts, i.e. for high quality video. The test patterns are designed for subjective and objective evaluation. The test patterns include a family of computer-generated spinning wheels to stress luminance-based macro-block motion estimation algorithms and images with strongly directional high-frequency content to stress quantization algorithms. In this paper we discuss the spinning wheel test pattern. It has been encoded at a variety of bit rates near the threshold for the perception of impairments. We have observed that impairment perceptibility depends on the local contrast. For the spinning wheel we report the contrast at the threshold for perception of impairments as a function of the bit rate. To quantify perceptual image blocking we have developed a metric which detects 'flats:' image blocks of constant (or near constant) luminance. The effectiveness of this metric is appraised.

  7. Supplemental Control for Aircraft Riding Qualities

    NASA Technical Reports Server (NTRS)

    Williams, Rolanda S.; Ashokkumar, C. R.; Homaifar, Abdollah

    1997-01-01

    The concept of preview control has been applied and proven to be successful in the automotive vehicle. These same concepts are now applied to an aircraft under the assumption that exogenous inputs (wind gust, turbulence, etc. ) can be measured. A supplemental control law for surface deflection is designed to compensate for the loss in performance in the presence of atmospheric disturbances. Fuzzy logic control is employed to handle the nonlinear, time varying characteristics of the disturbance. A methodology to tune the outer loop control parameters is presented.

  8. The interpretation of flying qualities requirements for flight control system design

    NASA Technical Reports Server (NTRS)

    Rynaski, E. G.

    1985-01-01

    An experimental flight test program was designed for the Total In Flight Simulator (TIFS) directed toward the interface between flying qualities requirements and flight control system design criteria. The eventual goal is to provide an interpretation or translation of flying qualities requirements for use by the flight control system designer. Specifically, an angle of attack and pitch rate command system matrix involving both short term and long term dynamics are specified for evaluation. Flying qualities criteria and flight control system configuration or architecture can be independent was demonstrated. Finally, additional configurations are proposed to evaluate the efficacy of dynamic decoupling.

  9. A task-based quality control metric for digital mammography.

    PubMed

    Bloomquist, A K Maki; Mainprize, J G; Mawdsley, G E; Yaffe, M J

    2014-11-01

    A reader study was conducted to tune the parameters of an observer model used to predict the detectability index (dʹ ) of test objects as a task-based quality control (QC) metric for digital mammography. A simple test phantom was imaged to measure the model parameters, namely, noise power spectrum,modulation transfer function and test-object contrast. These are then used ina non-prewhitening observer model, incorporating an eye-filter and internal noise, to predict dʹ. The model was tuned by measuring dʹ of discs in a four-alternative forced choice reader study. For each disc diameter, dʹ was used to estimate the threshold thicknesses for detectability. Data were obtained for six types of digital mammography systems using varying detector technologies and x-ray spectra. A strong correlation was found between measured and modeled values of dʹ, with Pearson correlation coefficient of 0.96. Repeated measurements from separate images of the test phantom show an average coefficient of variation in dʹ for different systems between 0.07 and 0.10. Standard deviations in the threshold thickness ranged between 0.001 and 0.017 mm. The model is robust and the results are relatively system independent, suggesting that observer model dʹ shows promise as a cross platform QC metric for digital mammography. PMID:25325670

  10. A task-based quality control metric for digital mammography

    NASA Astrophysics Data System (ADS)

    Maki Bloomquist, A. K.; Mainprize, J. G.; Mawdsley, G. E.; Yaffe, M. J.

    2014-11-01

    A reader study was conducted to tune the parameters of an observer model used to predict the detectability index (dʹ ) of test objects as a task-based quality control (QC) metric for digital mammography. A simple test phantom was imaged to measure the model parameters, namely, noise power spectrum, modulation transfer function and test-object contrast. These are then used in a non-prewhitening observer model, incorporating an eye-filter and internal noise, to predict dʹ. The model was tuned by measuring dʹ of discs in a four-alternative forced choice reader study. For each disc diameter, dʹ was used to estimate the threshold thicknesses for detectability. Data were obtained for six types of digital mammography systems using varying detector technologies and x-ray spectra. A strong correlation was found between measured and modeled values of dʹ, with Pearson correlation coefficient of 0.96. Repeated measurements from separate images of the test phantom show an average coefficient of variation in dʹ for different systems between 0.07 and 0.10. Standard deviations in the threshold thickness ranged between 0.001 and 0.017 mm. The model is robust and the results are relatively system independent, suggesting that observer model dʹ shows promise as a cross platform QC metric for digital mammography.

  11. Ascent thrust vector control system test

    NASA Technical Reports Server (NTRS)

    2008-01-01

    Testing of the Ascent Thrust Vector Control System in support of the Ares 1-X program at the Marshall Space Flight Center in Huntsville, Alabama. This image is extracted from a high definition video file and is the highest resolution available

  12. Concepts for continuous quality monitoring and station remote control

    NASA Astrophysics Data System (ADS)

    Ettl, M.; Neidhardt, A.; Rottmann, H.; Mühlbauer, M.; Plötz, C.; Himwich, E.; Beaudoin, C.; Szomoru, A.

    2011-07-01

    In the newly funded "Novel EXploration Pushing Robuste-VLBI Services", - project (NEXPReS) the Technische Universitaet Muenchen realize concepts for continuous quality monitoring and station remote control in cooperation with the Max-Planck-Institute for Radioastronomy, Bonn. NEXPReS is a three-year project aimed at further developing e-VLBI services of the European VLBI Network (EVN), with the goal of incorporating e-VLBI into every astronomical observation conducted by the EVN. This project focus on developments of an operational e-control system with authentication and authorization. It includes an appropriate role management with different remote access states for future observation strategies. To allow a flexible control of different systems in parallel sophisticated graphical user interfaces are designed and realized. It requires also a session oriented data management. Because of the higher degree of automation additional system parameters and information is collected with a new system monitoring. The whole system for monitoring and control is fully compatible to the NASA field system as extension. The concept will be proofed with regular tests between Wettzell and Effelsberg.

  13. 40 CFR 75.21 - Quality assurance and quality control requirements.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... SO2 monitoring system shall be considered out-of-control. The length of the out-of-control period..., non-quality-assured data for each disapproved system. (2) Out-of-control period. Whenever a continuous... other audit, the system is out-of-control. The owner or operator shall follow the procedures for...

  14. 40 CFR 75.21 - Quality assurance and quality control requirements.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... SO2 monitoring system shall be considered out-of-control. The length of the out-of-control period..., non-quality-assured data for each disapproved system. (2) Out-of-control period. Whenever a continuous... other audit, the system is out-of-control. The owner or operator shall follow the procedures for...

  15. Computerized real-time quality control program for analytical chemistry laboratories

    SciTech Connect

    Dill, M.S.; Floyd, M.A.; Morrow, R.W.

    1985-10-01

    A unique computer program has been developed for complete quality control/quality assurance of the operation and statistical control of the testing in the analytical laboratory. The system operates similar to a scanner on a production line with effective checkpoints and furnishes immediate feedback by automatically generated mail messages to appropriate personnel when any non-conformance is encountered. Corrective action is required by the technician prior to proceeding with the analysis.

  16. TL dosimetry for quality control of CR mammography imaging systems

    NASA Astrophysics Data System (ADS)

    Gaona, E.; Nieto, J. A.; Góngora, J. A. I. D.; Arreola, M.; Enríquez, J. G. F.

    The aim of this work is to estimate the average glandular dose with thermoluminescent (TL) dosimetry and comparison with quality imaging in computed radiography (CR) mammography. For a measuring dose, the Food and Drug Administration (FDA) and the American College of Radiology (ACR) use a phantom, so that dose and image quality are assessed with the same test object. The mammography is a radiological image to visualize early biological manifestations of breast cancer. Digital systems have two types of image-capturing devices, full field digital mammography (FFDM) and CR mammography. In Mexico, there are several CR mammography systems in clinical use, but only one system has been approved for use by the FDA. Mammography CR uses a photostimulable phosphor detector (PSP) system. Most CR plates are made of 85% BaFBr and 15% BaFI doped with europium (Eu) commonly called barium flourohalideE We carry out an exploratory survey of six CR mammography units from three different manufacturers and six dedicated X-ray mammography units with fully automatic exposure. The results show three CR mammography units (50%) have a dose greater than 3.0 mGy without demonstrating improved image quality. The differences between doses averages from TLD system and dosimeter with ionization chamber are less than 10%. TLD system is a good option for average glandular dose measurement for X-rays with a HVL (0.35-0.38 mmAl) and kVp (24-26) used in quality control procedures with ACR Mammography Accreditation Phantom.

  17. Global Health Diplomacy, Monitoring & Evaluation, and the Importance of Quality Assurance & Control: Findings from NIMH Project Accept (HPTN 043): A Phase III Randomized Controlled Trial of Community Mobilization, Mobile Testing, Same-Day Results, and Post-Test Support for HIV in Sub-Saharan Africa and Thailand

    PubMed Central

    Kevany, Sebastian; Khumalo-Sakutukwa, Gertrude; Singh, Basant; Chingono, Alfred; Morin, Stephen

    2016-01-01

    Background Provision and scale-up of high quality, evidence-based services is essential for successful international HIV prevention interventions in order to generate and maintain intervention uptake, study integrity and participant trust, from both health service delivery and diplomatic perspectives. Methods We developed quality assurance (QAC) procedures to evaluate staff fidelity to a cluster-randomized trial of the NIMH Project Accept (HPTN 043) assessing the effectiveness of a community-based voluntary counseling and testing strategy. The intervention was comprised of three components—Mobile Voluntary Counseling and Testing (MVCT), Community Mobilization (CM) and Post-Test Support Services (PTSS). QAC procedures were based on standardized criteria, and were designed to assess both provider skills and adherence to the intervention protocol. Supervisors observed a random sample of 5% to 10% of sessions each month and evaluated staff against multiple criteria on scales of 1–5. A score of 5 indicated 100% adherence, 4 indicated 95% adherence, and 3 indicated 90% adherence. Scores below 3 were considered unsatisfactory, and protocol deviations were discussed with the respective staff. Results During the first year of the intervention, the mean scores of MVCT and CM staff across the 5 study sites were 4 (95% adherence) or greater and continued to improve over time. Mean QAC scores for the PTSS component were lower and displayed greater fluctuations. Challenges to PTSS staff were identified as coping with the wide range of activities in the PTSS component and the novelty of the PTSS process. QAC fluctuations for PTSS were also associated with new staff hires or changes in staff responsibilities. Through constant staff monitoring and support, by Year 2, QAC scores for PTSS activities had reached those of MVCT and CM. Conclusions The implementation of a large-sale, evidence based HIV intervention requires extensive QAC to ensure implementation effectiveness

  18. Analysis of image quality for laser display scanner test

    NASA Astrophysics Data System (ADS)

    Specht, H.; Kurth, S.; Billep, D.; Gessner, T.

    2009-02-01

    The scanning laser display technology is one of the most promising technologies for highly integrated projection display applications (e. g. in PDAs, mobile phones or head mounted displays) due to its advantages regarding image quality, miniaturization level and low cost potential. As a couple of research teams found during their investigations on laser scanning projections systems, the image quality of such systems is - beside from laser source and video signal processing - crucially determined by the scan engine, including MEMS scanner, driving electronics, scanning regime and synchronization. Even though a number of technical parameters can be measured with high accuracy, the test procedure is challenging because the influence of these parameters on image quality is often insufficiently understood. Thus, in many cases it is not clear how to define limiting values for characteristic parameters. In this paper the relationship between parameters characterizing the scan engine and their influence on image quality will be discussed. Those include scanner topography, geometry of the path of light as well as trajectory parameters. Understanding this enables a new methodology for testing and characterization of the scan engine, based on evaluation of one or a series of projected test images. Due to the fact that the evaluation process can be easily automated by digital image processing this methodology has the potential to become integrated into the production process of laser displays.

  19. Validation of commercial DNA tests for quantitative beef quality traits.

    PubMed

    Van Eenennaam, A L; Li, J; Thallman, R M; Quaas, R L; Dikeman, M E; Gill, C A; Franke, D E; Thomas, M G

    2007-04-01

    Associations between 3 commercially available genetic marker panels (GeneSTAR Quality Grade, GeneSTAR Tenderness, and Igenity Tender-GENE) and quantitative beef traits were validated by the US National Beef Cattle Evaluation Consortium. Validation was interpreted to be the independent confirmation of the associations between genetic tests and phenotypes, as claimed by the commercial genotyping companies. Validation of the quality grade test (GeneSTAR Quality Grade) was carried out on 400 Charolais x Angus crossbred cattle, and validation of the tenderness tests (GeneSTAR Tenderness and Igenity Tender-GENE) was carried out on over 1,000 Bos taurus and Bos indicus cattle. The GeneSTAR Quality Grade marker panel is composed of 2 markers (TG5, a SNP upstream from the start of the first exon of thyroglobulin, and QG2, an anonymous SNP) and is being marketed as a test associated with marbling and quality grade. In this validation study, the genotype results from this test were not associated with marbling score; however, the association of substituting favorable alleles of the marker panel with increased quality grade (percentage of cattle grading Choice or Prime) approached significance (P < or = 0.06), mainly due to the effect of 1 of the 2 markers. The GeneSTAR Tenderness and Igenity TenderGENE marker panels are being marketed as tests associated with meat tenderness, as assessed by Warner-Bratzler shear force. These marker panels share 2 common mu-calpain SNP, but each has a different calpastatin SNP. In both panels, there were highly significant (P < 0.001) associations of the calpastatin marker and the mu-calpain haplotype with tenderness. The genotypic effects of the 2 tenderness panels were similar to each other, with a 1 kg difference in Warner-Bratzler shear force being observed between the most and least tender genotypes. Unbiased and independent validation studies are important to help build confidence in marker technology and also as a potential source of

  20. High-sensitivity dilatometer for quality-control use

    NASA Astrophysics Data System (ADS)

    Tomer, G. S.; Schlegel, G. L.; Gaal, P. S.

    1988-03-01

    A simple-to-operate dilatometer, intended for rapid quality-control testing of low-expansion materials in a single temperature interval, is described. The instrument employs a thermoelectric heat/cool element to supply the thermal environment for the sample and a high-sensitivity linear variable differential transformer (LVDT) for displacement measurement. The mechanical configuration is made so as to eliminate the need for quartz correction and to provide a 4∶1 mechanical advantage to the displacement signal for improved accuracy. Operating between 0 and 100°C, the machine proved to give consistently good results with materials having expansion coefficients as low as 0.5×10-6 °C-1. Representative data on some carbonaceous materials and fused silica (quartz) are given.

  1. Manager personality, manager service quality orientation, and service climate: test of a model.

    PubMed

    Salvaggio, Amy Nicole; Schneider, Benjamin; Nishii, Lisa H; Mayer, David M; Ramesh, Anuradha; Lyon, Julie S

    2007-11-01

    This article conceptually and empirically explores the relationships among manager personality, manager service quality orientation, and climate for customer service. Data were collected from 1,486 employees and 145 managers in grocery store departments (N = 145) to test the authors' theoretical model. Largely consistent with hypotheses, results revealed that core self-evaluations were positively related to managers' service quality orientation, even after dimensions of the Big Five model of personality were controlled, and that service quality orientation fully mediated the relationship between personality and global service climate. Implications for personality and organizational climate research are discussed. PMID:18020810

  2. Quality control of microelectronic wire bonds

    NASA Technical Reports Server (NTRS)

    Thiel, R. A.; Schmidt, G. D.

    1975-01-01

    Report evaluates ultrasonic bonding of small-diameter aluminum wire joined to ceramic substrates metalized with thin-film and thick-film gold. Quick testing technique for nondestructive location of poor wire bonds is also presented.

  3. Statistical process control for total quality

    NASA Astrophysics Data System (ADS)

    Ali, Syed W.

    1992-06-01

    The paper explains the techniques and applications of statistical process control (SPC). Examples of control charts used in the Poseidon program of the NASA ocean topography experiment (TOPEX) and a brief discussion of Taguchi methods are presented. It is noted that SPC involves everyone in process improvement by providing objective, workable data. It permits continuous improvement instead of merely aiming for all parts to be within a tolerance band.

  4. Web quality control for lectures: Supercourse and Amazon.com.

    PubMed

    Linkov, Faina; LaPorte, Ronald; Lovalekar, Mita; Dodani, Sunita

    2005-12-01

    Peer review has been at the corner stone of quality control of the biomedical journals in the past 300 years. With the emergency of the Internet, new models of quality control and peer review are emerging. However, such models are poorly investigated. We would argue that the popular system of quality control used in Amazon.com offers a way to ensure continuous quality improvement in the area of research communications on the Internet. Such system is providing an interesting alternative to the traditional peer review approaches used in the biomedical journals and challenges the traditional paradigms of scientific publishing. This idea is being explored in the context of Supercourse, a library of 2,350 prevention lectures, shared for free by faculty members from over 150 countries. Supercourse is successfully utilizing quality control approaches that are similar to Amazon.com model. Clearly, the existing approaches and emerging alternatives for quality control in scientific communications needs to be assessed scientifically. Rapid explosion of internet technologies could be leveraged to produce better, more cost effective systems for quality control in the biomedical publications and across all sciences. PMID:16342339

  5. Achieving indoor air quality through contaminant control

    SciTech Connect

    Katzel, J.

    1995-07-10

    Federal laws outlining industry`s responsibilities in creating a healthy, hazard-free workspace are well known. OSHA`s laws on interior air pollution establish threshold limit values (TLVs) and permissible exposure limits (PELs) for more than 500 potentially hazardous substances found in manufacturing operations. Until now, OSHA has promulgated regulations only for the manufacturing environment. However, its recently-proposed indoor air quality (IAQ) ruling, if implemented, will apply to all workspaces. It regulates IAQ, including environmental tobacco smoke, and requires employers to write and implement IAQ compliance plans.

  6. Quality Control of Fungal and Viral Biocontrol Agents

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Constraints to the use of the “inundative” or “biopesticide” strategy of biological control include a lack of consistent pest control efficacy, short product shelf-life, and costly production and stabilization processes. Quality control measures that standardize the production, stabilization, formu...

  7. Pharmacist Glycemic Control Team Improves Quality of Glycemic Control in Surgical Patients with Perioperative Dysglycemia

    PubMed Central

    Mularski, Karen SP; Yeh, Cynthia P; Bains, Jaspreet K; Mosen, David M; Hill, Ariel K; Mularski, Richard A

    2012-01-01

    Context: Perioperative hyperglycemia is a risk factor for increased morbidity and mortality. Improved glycemic control has been demonstrated to reduce surgical site infections, reduce perioperative morbidity, and reduce length of stay. However, safe and effective perioperative glycemic control can be limited by expert clinician availability. Objective: To improve quality by reliably providing safe and effective glycemic control to surgical patients with diabetes or stress hyperglycemia. Design: A designated group of pharmacists, the Glycemic Control Team (GCT), worked under protocol, on a consultation basis, to manage perioperative dysglycemia during hospitalization. We used a pre-post, observational study design to assess the effectiveness of the intervention and implementation of the GCT. Main Outcome Measures: The proportion of patients pre- and postintervention with good glycemic control and with hypoglycemia were measured and compared. We defined good glycemic control as having all, or all but one, point-of-care blood glucose values between 70–180 mg/dL in each 24-hour period. We defined hypoglycemia as having any point-of-care test glucose value <70mg/dL in any of the 3 days evaluated. Results: During the preimplementation period, 77.4% of postoperative patient days demonstrated good glycemic control. In the postimplementation period, this percentage increased to 90.3%. Over the same period, the rate of hypoglycemia decreased from 8.6% to 4.6%. Conclusion: Implementation of a pharmacist team to manage glycemic control in hospitalized, postoperative patients led to safer and better quality of glycemic care as measured by improved glycemic control and lower rates of hypoglycemia. PMID:22529756

  8. Flightability as a quality control parameter for the codling moth, Cydia pomonella

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Quality assurance tests and standards are requisite for maximizing fitness of insect species that are mass-reared for release in area-wide autocidal control programs. Because of the extensive use of the SIT to control/eradicate fruit flies and the development of international trade in sterile fruit ...

  9. Flight testing and frequency domain analysis for rotorcraft handling qualities characteristics

    NASA Technical Reports Server (NTRS)

    Ham, Johnnie A.; Gardner, Charles K.; Tischler, Mark B.

    1993-01-01

    A demonstration of frequency domain flight testing techniques and analyses was performed on a U.S. Army OH-58D helicopter in support of the OH-58D Airworthiness and Flight Characteristics Evaluation and the Army's development and ongoing review of Aeronautical Design Standard 33C, Handling Qualities Requirements for Military Rotorcraft. Hover and forward flight (60 knots) tests were conducted in 1 flight hour by Army experimental test pilots. Further processing of the hover data generated a complete database of velocity, angular rate, and acceleration frequency responses to control inputs. A joint effort was then undertaken by the Airworthiness Qualification Test Directorate (AQTD) and the U.S. Army Aeroflightdynamics Directorate (AFDD) to derive handling qualities information from the frequency response database. A significant amount of information could be extracted from the frequency domain database using a variety of approaches. This report documents numerous results that have been obtained from the simple frequency domain tests; in many areas, these results provide more insight into the aircraft dynamics that affect handling qualities than to traditional flight tests. The handling qualities results include ADS-33C bandwidth and phase delay calculations, vibration spectral determinations, transfer function models to examine single axis results, and a six degree of freedom fully coupled state space model. The ability of this model to accurately predict aircraft responses was verified using data from pulse inputs. This report also documents the frequency-sweep flight test technique and data analysis used to support the tests.

  10. Flight-testing and frequency-domain analysis for rotorcraft handling qualities

    NASA Technical Reports Server (NTRS)

    Ham, Johnnie A.; Gardner, Charles K.; Tischler, Mark B.

    1995-01-01

    A demonstration of frequency-domain flight-testing techniques and analysis was performed on a U.S. Army OH-58D helicopter in support of the OH-58D Airworthiness and Flight Characteristics Evaluation and of the Army's development and ongoing review of Aeronautical Design Standard 33C, Handling Qualities Requirements for Military Rotorcraft. Hover and forward flight (60 kn) tests were conducted in 1 flight hour by Army experimental test pilots. Further processing of the hover data generated a complete database of velocity, angular-rate, and acceleration-frequency responses to control inputs. A joint effort was then undertaken by the Airworthiness Qualification Test Dirtectorate and the U.S. Army Aeroflightdynamics Directorate to derive handling-quality information from the frequency-domain database using a variety of approaches. This report documents numerous results that have been obtained from the simple frequency-domain tests; in many areas, these results provide more insight into the aircraft dynmamics that affect handling qualities than do traditional flight tests. The handling-quality results include ADS-33C bandwidth and phase-delay calculations, vibration spectral determinations, transfer-function models to examine single-axis results, and a six-degree-of-freedom fully coupled state-space model. The ability of this model to accurately predict responses was verified using data from pulse inputs. This report also documents the frequency-sweep flight-test technique and data analysis used to support the tests.

  11. Mesh quality control for multiply-refined tetrahedral grids

    NASA Technical Reports Server (NTRS)

    Biswas, Rupak; Strawn, Roger

    1994-01-01

    A new algorithm for controlling the quality of multiply-refined tetrahedral meshes is presented in this paper. The basic dynamic mesh adaption procedure allows localized grid refinement and coarsening to efficiently capture aerodynamic flow features in computational fluid dynamics problems; however, repeated application of the procedure may significantly deteriorate the quality of the mesh. Results presented show the effectiveness of this mesh quality algorithm and its potential in the area of helicopter aerodynamics and acoustics.

  12. LEO life testing with different charge control

    NASA Technical Reports Server (NTRS)

    Baron, F.

    1985-01-01

    The effect of charge control on the performance of Nickel-Cadmium batteries is very important. The results of three tests performed in the Battery Test Centre of ESTEC are described. Two techniques were employed: (1) the tapering method well known for space applications, and (2) the temperature derivative technique (TDT) developed by ESTEC. In addition, a comparative study has been made between the behavior of a group of 3 batteries charged and discharged in parallel compared to an identical group discharged in parallel, but charged individually. An approach of evolution laws for the main electrical characteristics of cells is presented.

  13. Academic Quality Control in Nigerian Universities: Exploring Lecturers' Perceptions

    ERIC Educational Resources Information Center

    Obiekezie, E. O.; Ejemot-Nwadiaro, R. I.; Essien, M. I.; Timothy, A. Essien

    2014-01-01

    The level of job performance, international comparability and competitiveness of Nigerian university graduates are burning issues. Consequently, the academic quality of Nigerian universities has come under severe criticism. Since university lecturers are key players in quality control in universities, this study explored their perceptions of…

  14. 115. QUALITY CONTROL BOARD FOR MAINTENANCE AND INSPECTION AT SOUTH ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    115. QUALITY CONTROL BOARD FOR MAINTENANCE AND INSPECTION AT SOUTH SIDE OF MECHANICAL AND ELECTRICAL ROOM (110), LSB (BLDG. 770), FACING WEST ON EXTERIOR WALL OF QUALITY ASSURANCE ROOM (106A) - Vandenberg Air Force Base, Space Launch Complex 3, Launch Pad 3 West, Napa & Alden Roads, Lompoc, Santa Barbara County, CA

  15. 42 CFR 84.41 - Quality control plans; contents.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... accordance with 5 U.S.C. 552(a) and 1 CFR part 51. Copies may be obtained from DODSSP, Standardization... 42 Public Health 1 2010-10-01 2010-10-01 false Quality control plans; contents. 84.41 Section 84... AND HEALTH RESEARCH AND RELATED ACTIVITIES APPROVAL OF RESPIRATORY PROTECTIVE DEVICES Quality...

  16. Testing scanners for the quality of output images

    NASA Astrophysics Data System (ADS)

    Concepcion, Vicente P.; Nadel, Lawrence D.; D'Amato, Donald P.

    1995-01-01

    Document scanning is the means through which documents are converted to their digital image representation for electronic storage or distribution. Among the types of documents being scanned by government agencies are tax forms, patent documents, office correspondence, mail pieces, engineering drawings, microfilm, archived historical papers, and fingerprint cards. Increasingly, the resulting digital images are used as the input for further automated processing including: conversion to a full-text-searchable representation via machine printed or handwritten (optical) character recognition (OCR), postal zone identification, raster-to-vector conversion, and fingerprint matching. These diverse document images may be bi-tonal, gray scale, or color. Spatial sampling frequencies range from about 200 pixels per inch to over 1,000. The quality of the digital images can have a major effect on the accuracy and speed of any subsequent automated processing, as well as on any human-based processing which may be required. During imaging system design, there is, therefore, a need to specify the criteria by which image quality will be judged and, prior to system acceptance, to measure the quality of images produced. Unfortunately, there are few, if any, agreed-upon techniques for measuring document image quality objectively. In the output images, it is difficult to distinguish image degradation caused by the poor quality of the input paper or microfilm from that caused by the scanning system. We propose several document image quality criteria and have developed techniques for their measurement. These criteria include spatial resolution, geometric image accuracy, (distortion), gray scale resolution and linearity, and temporal and spatial uniformity. The measurement of these criteria requires scanning one or more test targets along with computer-based analyses of the test target images.

  17. Quality control system response to stochastic growth of amyloid fibrils.

    PubMed

    Pigolotti, Simone; Lizana, Ludvig; Otzen, Daniel; Sneppen, Kim

    2013-05-01

    We introduce a stochastic model describing aggregation of misfolded proteins and degradation by the protein quality control system in a single cell. Aggregate growth is contrasted by the cell quality control system, that attacks them at different stages of the growth process, with an efficiency that decreases with their size. Model parameters are estimated from experimental data. Two qualitatively different behaviors emerge: a homeostatic state, where the quality control system is stable and aggregates of large sizes are not formed, and an oscillatory state, where the quality control system periodically breaks down, allowing for formation of large aggregates. We discuss how these periodic breakdowns may constitute a mechanism for the development of neurodegenerative diseases. PMID:23524241

  18. Quality of prenatal care questionnaire: instrument development and testing

    PubMed Central

    2014-01-01

    Background Utilization indices exist to measure quantity of prenatal care, but currently there is no published instrument to assess quality of prenatal care. The purpose of this study was to develop and test a new instrument, the Quality of Prenatal Care Questionnaire (QPCQ). Methods Data for this instrument development study were collected in five Canadian cities. Items for the QPCQ were generated through interviews with 40 pregnant women and 40 health care providers and a review of prenatal care guidelines, followed by assessment of content validity and rating of importance of items. The preliminary 100-item QPCQ was administered to 422 postpartum women to conduct item reduction using exploratory factor analysis. The final 46-item version of the QPCQ was then administered to another 422 postpartum women to establish its construct validity, and internal consistency and test-retest reliability. Results Exploratory factor analysis reduced the QPCQ to 46 items, factored into 6 subscales, which subsequently were validated by confirmatory factor analysis. Construct validity was also demonstrated using a hypothesis testing approach; there was a significant positive association between women’s ratings of the quality of prenatal care and their satisfaction with care (r = 0.81). Convergent validity was demonstrated by a significant positive correlation (r = 0.63) between the “Support and Respect” subscale of the QPCQ and the “Respectfulness/Emotional Support” subscale of the Prenatal Interpersonal Processes of Care instrument. The overall QPCQ had acceptable internal consistency reliability (Cronbach’s alpha = 0.96), as did each of the subscales. The test-retest reliability result (Intra-class correlation coefficient = 0.88) indicated stability of the instrument on repeat administration approximately one week later. Temporal stability testing confirmed that women’s ratings of their quality of prenatal care did not change as a result of giving

  19. Development of Quality Control Procedures for Lepidoptera

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Lepidopteran species are among the most destructive insect pests throughout the world. The sterile insect technique (SIT), within an area-wide integrated pest management (AW-IPM) approach, has proven to be a valuable tactic for controlling and eradicating important moth pests. Improving laboratory...

  20. Quality control of thermal sprayed coatings with an optoelectric sensor

    SciTech Connect

    Rothe, H.; Brandt, O.; Kasper, A.

    1995-12-31

    This paper reports on the development of a fully optoelectronic optical sensor that has been used for investigations concerning quality control of the high velocity oxygen fuel (HVOF) flame spraying process. The authors focused on the following parameters: WoC with Co, CoCr, Ni at T < 500 C, and Cr{sub 3}C{sub 2} with Ni-Cr, Ni at T < 900 C. Until recently, there was no non-destructive testing (NDT) approach for flame spraying available, which is a major drawback for many critical applications, like in the aerospace industry. For instance, while cooling down after spraying, cracks in the coatings may occur caused by strain. Furthermore, edges may cause similar damage to the coating. The idea was to provide the flame spraying industry with a measurement technology that is applicable in the workshop, has a contactless principle of operation and is fast compared to the commonly used metallography or scanning electron microscopy. The approach is designed for use close to the process, i.e. coating morphology was not the focus of the investigations. On the contrary, they tried to extract quality related information from surface microtopography which can be obtained in a non-destructive and affordable manner. Main points covered in this paper are theoretical considerations, the operational principles and construction of the sensor head, and quantitative metrology of surface damage such as variations in rms-roughness and cracks.

  1. [Analysis of the results of the SEIMC External Quality Control Program. Year 2014].

    PubMed

    Gopegui Bordes, Enrique Ruiz de; Guna Serrano, M Del Remedio; Orta Mira, Nieves; Medina González, Rafael; Rosario Ovies, María; Poveda, Marta; Gimeno Cardona, Concepción

    2016-07-01

    The External Quality Control Program of the Spanish Society of Infectious Diseases and Clinical Microbiology (SEIMC) include controls for bacteriology, serology, mycology, parasitology, mycobacteria, virology and molecular microbiology. This article presents the most relevant conclusions and lessons from the 2014 controls. As a whole, the results obtained in 2014 confirm the excellent skill and good technical standards found in previous editions. However, erroneous results can be obtained in any laboratory and in clinically relevant determinations. Once again, the results of the SEIMC program highlighted the need to implement both internal and external controls in order to assure the maximal quality of the microbiological tests. PMID:27474240

  2. Quality Evaluation By Acousto-Ultrasonic Testing Of Composites

    NASA Technical Reports Server (NTRS)

    Vary, Alex

    1989-01-01

    Promising nondestructive-testing method based on ultrasonic simulation of stress waves. Report reviews acousto-ultrasonic technology for nondestructive testing. Discusses principles, suggests advanced signal-analysis schemes for development, and presents potential applications. Acousto-ultrasonics applied principally to assess defects in laminated and filament-wound fiber-reinforced composite materials. Technique used to determine variations in such properties as tensile, shear, and flexural strengths and reductions in strength and toughness caused by defects. Also used to evaluate states of cure, porosities, orientation of fibers, volume fractions of fibers, bonding between fibers and matrices, and qualities of interlaminar bonds.

  3. Control substances and alcohol use and testing

    SciTech Connect

    Przybylski, J.L.

    1994-07-01

    The Omnibus Transportation Employee Testing Act was signed into law in October of 1991. The Omnibus Transportation Employee Testing Act of 1991 required the United States Department of Transportation (DOT) to enact regulations requiring the testing of employees that perform ``safety sensitive functions`` for illegal controlled substance use and alcohol misuse. The Transportation Management Division, Office of Environmental Restoration and Waste Management (TMD/EM-261), United States Department of Energy (DOE), Training Program Manager is committed to promoting the availability of the necessary information to those affected members of the Department of Energy (DOE) community in an effort to attain the highest possible level of regulatory compliance and to enhance the safety of each individual in the workplace.

  4. Laboratory tests of sludge-control additives

    SciTech Connect

    Tatnall, R.E.

    1996-07-01

    Laboratory {open_quotes}jar{close_quotes} tests compared eleven different fuel oil and diesel fuel sludge-control additives. Factors studied included (1) ability to disperse and prevent buildup of sludge deposits on surfaces, (2) ability to protect steel from corrosion, (3) ability to inhibit growth and proliferation of bacteria, and (4) ability to disperse water. Results varied greatly, and it was found that many commercial products do not do what they claim. It is concluded that fuel retailers should not believe manufacturers` claims for their additive products, but rather should test such products themselves to be sure that the benefits of treatment are real. A simplified form of the procedure used here is proposed as one way for dealers to do such testing.

  5. Control system health test system and method

    DOEpatents

    Hoff, Brian D.; Johnson, Kris W.; Akasam, Sivaprasad; Baker, Thomas M.

    2006-08-15

    A method is provided for testing multiple elements of a work machine, including a control system, a component, a sub-component that is influenced by operations of the component, and a sensor that monitors a characteristic of the sub-component. In one embodiment, the method is performed by the control system and includes sending a command to the component to adjust a first parameter associated with an operation of the component. Also, the method includes detecting a sensor signal from the sensor reflecting a second parameter associated with a characteristic of the sub-component and determining whether the second parameter is acceptable based on the command. The control system may diagnose at least one of the elements of the work machine when the second parameter of the sub-component is not acceptable.

  6. Experience with ISO quality control in assisted reproductive technology.

    PubMed

    Alper, Michael M

    2013-12-01

    Assisted reproductive technology (ART) programs are complex organizations requiring the integration of multiple disciplines. ISO 9001:2008 is a quality management system that is readily adaptable to an ART program. The value that ISO brings to the entire organization includes control of documents, clear delineation of responsibilities of staff members, documentation of the numerous processes and procedures, improvement in tracking and reducing errors, and overall better control of systems. A quality ART program sets quality objectives and monitors their progress. ISO provides a sense of transparency within the organization and clearer understanding of how service is provided to patients. Most importantly, ISO provides the framework to allow for continual improvement. PMID:24112531

  7. Metal cladding envelope problems, retrofit solutions, and quality control investigations

    NASA Astrophysics Data System (ADS)

    Colantonio, Antonio

    1992-04-01

    This paper deals with a case study of a building envelope retrofit of an insulated sheet steel and corrugated metal clad building. The building in discussion is a satellite testing facility which requires specific clean room conditions with controlled interior temperature (22 degree(s)C +/- 1 degree(s)C) and high relative humidity conditions (45% +/- 3%) to facilitate satellite testing programs. Preliminary mechanical system inspections indicated substantial increase in air intake to make up for air leakage losses. An infrared inspection along with an approximate air leakage test of the building envelope was requested by the client to determine the magnitude of the building envelope problem. This investigation concluded that significant air leakage was present throughout the building envelope and that existing mechanical systems did not have sufficient capacity to pressurize the building and negate wind and stack effect. Exfiltration particularly through openings on the top sections of the building were causing interior moisture to saturate wall insulation and render it ineffective. Concern for rusting of metal components was indicated. The subsequent envelope analysis discovered a number of typical metal building details that led to poor air tightness and wall insulation ineffectiveness. These were correlated to infrared investigation data. The retrofit solutions produced for this building not only apply to this building but to other similar building types. Further investigations indicated that air leakage and mechanical system performance were significant problems with buildings using metal cladding systems comparable to this building. Quality control before, during and after construction was identified as an important function of the architectural commissioning of the retrofit work and infrared investigations were used to verify locations of air leakage and insulation effectiveness.

  8. Multi-axis transient vibration testing of space objects: Test philosophy, test facility, and control strategy

    NASA Technical Reports Server (NTRS)

    Lachenmayr, Georg

    1992-01-01

    IABG has been using various servohydraulic test facilities for many years for the reproduction of service loads and environmental loads on all kinds of test objects. For more than 15 years, a multi-axis vibration test facility has been under service, originally designed for earthquake simulation but being upgraded to the demands of space testing. First tests with the DFS/STM showed good reproduction accuracy and demonstrated the feasibility of transient vibration testing of space objects on a multi-axis hydraulic shaker. An approach to structural qualification is possible by using this test philosophy. It will be outlined and its obvious advantages over the state-of-the-art single-axis test will be demonstrated by example results. The new test technique has some special requirements to the test facility exceeding those of earthquake testing. Most important is the high reproduction accuracy demanded for a sophisticated control system. The state-of-the-art approach of analog closed-loop control circuits for each actuator combined with a static decoupling network and an off-line iterative waveform control is not able to meet all the demands. Therefore, the future over-all control system is implemented as hierarchical full digital closed-loop system on a highly parallel transputer network. The innermost layer is the digital actuator controller, the second one is the MDOF-control of the table movement. The outermost layer would be the off-line iterative waveform control, which is dedicated only to deal with the interaction of test table and test object or non-linear effects. The outline of the system will be presented.

  9. Nuclear Technology Series. Course 14: Introduction to Quality Assurance/Quality Control.

    ERIC Educational Resources Information Center

    Technical Education Research Center, Waco, TX.

    This technical specialty course is one of thirty-five courses designed for use by two-year postsecondary institutions in five nuclear technician curriculum areas: (1) radiation protection technician, (2) nuclear instrumentation and control technician, (3) nuclear materials processing technician, (4) nuclear quality-assurance/quality-control…

  10. HANDBOOK: QUALITY ASSURANCE/QUALITY CONTROL (QA/QC) PROCEDURES FOR HAZARDOUS WASTE INCINERATION

    EPA Science Inventory

    Resource Conservation and Recovery Act regulations for hazardous waste incineration require trial burns by permit applicants. uality Assurance Project Plan (QAPjP) must accompany a trial burn plan with appropriate quality assurance/quality control procedures. uidance on the prepa...

  11. Quality control throughout the production process of infant food.

    PubMed

    Hamrin, Pia; Hoeft, Birgit

    2012-01-01

    The manufacture of infant food is a highly complex process and needs an effective quality control beyond classical in-process parameters and a final microbiological analysis. To ensure a safe end -product, various tools, such as the Hazard Analysis Critical Control Points (HACCP), have been developed to facilitate the management of food safety. Every single infant formula ingredient must have an excellent quality and safety approach because even if an ingredient is used in very small quantities in a single product, serious consequences may arise if the quality and product safety are not taken seriously by the ingredient manufacturer. The purpose of this article was twofold: firstly, to briefly describe existing Quality Management Systems and, secondly, to highlight the consequences of non-quality. PMID:22699770

  12. The process of managerial control in quality improvement initiatives.

    PubMed

    Slovensky, D J; Fottler, M D

    1994-11-01

    The fundamental intent of strategic management is to position an organization with in its market to exploit organizational competencies and strengths to gain competitive advantage. Competitive advantage may be achieved through such strategies as low cost, high quality, or unique services or products. For health care organizations accredited by the Joint Commission on Accreditation of Healthcare Organizations, continually improving both processes and outcomes of organizational performance--quality improvement--in all operational areas of the organization is a mandated strategy. Defining and measuring quality and controlling the quality improvement strategy remain problematic. The article discusses the nature and processes of managerial control, some potential measures of quality, and related information needs. PMID:10138526

  13. Interaction of feel system and flight control system dynamics on lateral flying qualities

    NASA Technical Reports Server (NTRS)

    Bailey, Randall E.; Powers, Bruce G.; Shafer, Mary F.

    1988-01-01

    An investigation of feel system and flight control system dynamics on lateral flying qualities was conducted using the variable stability USAF NT-33 aircraft. Experimental variations in feel system natural frequency, force-deflection gradient, control system command architecture type, flight control system filter frequency, and control system delay were made. The experiment data include pilot ratings using the Cooper-Harper (1969) rating scale, pilot comments, and tracking performance statistic. Three test pilots served as evaluators. The data indicate that as the feel system natural frequency is reduced lateral flying qualities degrade. At the slowest feel system frequency, the closed-loop response becomes nonlinear with a 'bobweight' effect apparent in the feel system. Feel system influences were essentially independent of the control system architecture. The flying qualities influence due to the feel system was different than when the identical dynamic systenm was used as a flight control system element.

  14. Technical assessment for quality control of resins

    NASA Technical Reports Server (NTRS)

    Gosnell, R. B.

    1977-01-01

    Survey visits to companies involved in the manufacture and use of graphite-epoxy prepregs were conducted to assess the factors which may contribute to variability in the mechanical properties of graphite-epoxy composites. In particular, the purpose was to assess the contributions of the epoxy resins to variability. Companies represented three segments of the composites industry - aircraft manufacturers, prepreg manufacturers, and epoxy resin manufacturers. Several important sources of performance variability were identified from among the complete spectrum of potential sources which ranged from raw materials to composite test data interpretation.

  15. 10 CFR 71.125 - Control of measuring and test equipment.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false Control of measuring and test equipment. 71.125 Section 71.125 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) PACKAGING AND TRANSPORTATION OF RADIOACTIVE MATERIAL Quality Assurance § 71.125 Control of measuring and test equipment. The licensee, certificate holder, and applicant for a CoC shall...

  16. 10 CFR 71.125 - Control of measuring and test equipment.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 2 2013-01-01 2013-01-01 false Control of measuring and test equipment. 71.125 Section 71.125 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) PACKAGING AND TRANSPORTATION OF RADIOACTIVE MATERIAL Quality Assurance § 71.125 Control of measuring and test equipment. The licensee, certificate holder, and applicant for a CoC shall...

  17. 10 CFR 71.125 - Control of measuring and test equipment.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 2 2011-01-01 2011-01-01 false Control of measuring and test equipment. 71.125 Section 71.125 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) PACKAGING AND TRANSPORTATION OF RADIOACTIVE MATERIAL Quality Assurance § 71.125 Control of measuring and test equipment. The licensee, certificate holder, and applicant for a CoC shall...

  18. 10 CFR 71.125 - Control of measuring and test equipment.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 2 2014-01-01 2014-01-01 false Control of measuring and test equipment. 71.125 Section 71.125 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) PACKAGING AND TRANSPORTATION OF RADIOACTIVE MATERIAL Quality Assurance § 71.125 Control of measuring and test equipment. The licensee, certificate holder, and applicant for a CoC shall...

  19. 10 CFR 71.125 - Control of measuring and test equipment.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 2 2012-01-01 2012-01-01 false Control of measuring and test equipment. 71.125 Section 71.125 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) PACKAGING AND TRANSPORTATION OF RADIOACTIVE MATERIAL Quality Assurance § 71.125 Control of measuring and test equipment. The licensee, certificate holder, and applicant for a CoC shall...

  20. Development and flight test results of an autothrottle control system at Mach 3 cruise

    NASA Technical Reports Server (NTRS)

    Gilyard, G. B.; Burken, J. J.

    1980-01-01

    Flight test results obtained with the original Mach hold autopilot designed the YF-12C airplane which uses elevator control and a newly developed Mach hold system having an autothrottle integrated with an altitude hold autopilot system are presented. The autothrottle tests demonstrate good speed control at high Mach numbers and high altitudes while simultaneously maintaining control over altitude and good ride qualities. The autothrottle system was designed to control either Mach number or knots equivalent airspeed (KEAS). Excellent control of Mach number or KEAS was obtained with the autothrottle system when combined with altitude hold. Ride qualities were significantly better than with the conventional Mach hold system.

  1. Quality control for diagnostic oral microbiology laboratories in European countries

    PubMed Central

    Rautemaa-Richardson, Riina; der Reijden Wa, Wil A Van; Dahlen, Gunnar; Smith, Andrew J.

    2011-01-01

    Participation in diagnostic microbiology internal and external quality control (QC) processes is good laboratory practice and an essential component of a quality management system. However, no QC scheme for diagnostic oral microbiology existed until 2009 when the Clinical Oral Microbiology (COMB) Network was created. At the European Oral Microbiology Workshop in 2008, 12 laboratories processing clinical oral microbiological samples were identified. All these were recruited to participate into the study and six laboratories from six European countries completed both the online survey and the first QC round. Three additional laboratories participated in the second round. Based on the survey, European oral microbiology laboratories process a significant (mean per laboratory 4,135) number of diagnostic samples from the oral cavity annually. A majority of the laboratories did not participate in any internal or external QC programme and nearly half of the laboratories did not have standard operating procedures for the tests they performed. In both QC rounds, there was a large variation in the results, interpretation and reporting of antibiotic susceptibility testing among the laboratories. In conclusion, the results of this study demonstrate the need for harmonisation of laboratory processing methods and interpretation of results for oral microbiology specimens. The QC rounds highlighted the value of external QC in evaluating the efficacy and safety of processes, materials and methods used in the laboratory. The use of standardised methods is also a prerequisite for multi-centre epidemiological studies that can provide important information on emerging microbes and trends in anti-microbial susceptibility for empirical prescribing in oro-facial infections. PMID:22084647

  2. Research review: Indoor air quality control techniques

    SciTech Connect

    Fisk, W.J.

    1986-10-01

    Techniques for controlling the concentration of radon, formaldehyde, and combustion products in the indoor air are reviewed. The most effective techniques, which are generally based on limiting or reducing indoor pollutant source strengths, can decrease indoor pollutant concentrations by a factor of 3 to 10. Unless the initial ventilation rate is unusually low, it is difficult to reduce indoor pollutant concentrations more than approximately 50% by increasing the ventilation rate of an entire building. However, the efficiency of indoor pollutant control by ventilation can be enhanced through the use of local exhaust ventilation near concentrated sources of pollutants, by minimizing short circuiting of air from supply to exhaust when pollutant sources are dispersed and, in some situations, by promoting a displacement flow of air and pollutants toward the exhaust. Active air cleaning is also examined briefly. Filtration and electrostatic air cleaning for removal of particles from the indoor air are the most practical and effective currently available techniques of air cleaning. 49 refs., 7 figs.

  3. [Our experience with outside laboratory quality control].

    PubMed

    Dochev, D; Arakasheva, V; Nashkov, A; Tsachev, K

    1979-01-01

    The results from the national outside laboratory qualitative control of the clinical diagnostic laboratory investigations for the period September 1975 -- May 1977 were described. The following interlaboratory discrepancy was found on base of a systematic analysis of the data from the last two ring-like check-ups, November 1976 and May 1977, exressed by the variation coefficient (V.C. %); total protein, sodium, potassium and chlorides -- under 10%; cholesterol, urea and total fats -- between 10 and 20%; calcium, phosphorus, iron and creatinine -- over 20%. The highest per cent of admissible results are found with total protein -- to 85%; cholesterol -- to 70.38%; glucosa -- to 73.17%, urea -- to 69.23%, potassium -- to 59.46%, chlorides -- to 57.9%. With sodium, phosphorus, calcium, iron creatinine and uric acid the "admissibility" fluctuates about or under 50 per cent. The values of the qualitative-control indices discussed are comparable with the values obtained from them in the interlaboratory comparisons of other countries. PMID:494628

  4. 21 CFR 111.105 - What must quality control personnel do?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 2 2010-04-01 2010-04-01 false What must quality control personnel do? 111.105... for Quality Control § 111.105 What must quality control personnel do? Quality control personnel must... manufacturing record. To do so, quality control personnel must perform operations that include: (a) Approving...

  5. 40 CFR 81.112 - Charleston Intrastate Air Quality Control Region.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Quality Control Regions § 81.112 Charleston Intrastate Air Quality Control Region. The Charleston Intrastate Air Quality Control Region (South Carolina) consists of the territorial area encompassed by the... Quality Control Region: Region 1. 81.107Greenwood Intrastate Air Quality Control Region: Region 2....

  6. 40 CFR 81.112 - Charleston Intrastate Air Quality Control Region.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Quality Control Regions § 81.112 Charleston Intrastate Air Quality Control Region. The Charleston Intrastate Air Quality Control Region (South Carolina) consists of the territorial area encompassed by the... Quality Control Region: Region 1. 81.107Greenwood Intrastate Air Quality Control Region: Region 2....

  7. 21 CFR 111.105 - What must quality control personnel do?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 2 2011-04-01 2011-04-01 false What must quality control personnel do? 111.105... for Quality Control § 111.105 What must quality control personnel do? Quality control personnel must... manufacturing record. To do so, quality control personnel must perform operations that include: (a) Approving...

  8. The evaluation of waste, surface and ground water quality using the Allium test procedure.

    PubMed

    Smaka-Kincl, V; Stegnar, P; Lovka, M; Toman, M J

    1996-07-01

    The bulbs of Allium cepa were grown in test liquids of various pollution levels as follows: undiluted industrial and municipal waste water; biological treatment plant output water; water from the Drava river upstream and downstream of the city of Maribor; and non-chlorinated drinking water as a negative control test. The paper presents the response of the Allium cepa genetic material to the presence of potential cytotoxic and genotoxic substances in test liquids and the suitability of the Allium cepa testing procedure as a method for short-term determination of water pollution level. The suitability of the Allium test procedure as a system for environmental monitoring is presented. The influence of water pollution on macroscopic and cytologic parameters of the common onion by application of the biological testing method was examined. The macroscopic parameter was inhibition of root growth. The cytological parameters were: aberrant cells in metaphase and anaphase, index of micronuclei appearance and inhibition of cell division. The possibility of categorization the different polluted test liquids into quality classes is presented according to the influence of the test liquids on macroscopic and cytologic parameters. Test liquids are divided into 8 quality classes: the first class is the least polluted surface waters, the second and the third classes are more polluted surface water, the fourth and the fifth classes are biological treatment plant output waters, the sixth till the eighth quality classes are untreated waste waters. The most polluted test liquids (untreated industrial and municipal waste waters) caused sublethal and even lethal effects. The most polluted tested liquids cause the inhibition of root growth over 50% (even up to 74%), decrease of mitotic index over 36% (even up to 66%), increase of presence of interphase cells with micronuclei over 3% and increase of presence of aberrant cells for more than 10 times in comparison to control test. PMID

  9. A short term quality control tool for biodegradable microspheres.

    PubMed

    D'Souza, Susan; Faraj, Jabar A; Dorati, Rossella; DeLuca, Patrick P

    2014-06-01

    Accelerated in vitro release testing methodology has been developed as an indicator of product performance to be used as a discriminatory quality control (QC) technique for the release of clinical and commercial batches of biodegradable microspheres. While product performance of biodegradable microspheres can be verified by in vivo and/or in vitro experiments, such evaluation can be particularly challenging because of slow polymer degradation, resulting in extended study times, labor, and expense. Three batches of Leuprolide poly(lactic-co-glycolic acid) (PLGA) microspheres having varying morphology (process variants having different particle size and specific surface area) were manufactured by the solvent extraction/evaporation technique. Tests involving in vitro release, polymer degradation and hydration of the microspheres were performed on the three batches at 55°C. In vitro peptide release at 55°C was analyzed using a previously derived modification of the Weibull function termed the modified Weibull equation (MWE). Experimental observations and data analysis confirm excellent reproducibility studies within and between batches of the microsphere formulations demonstrating the predictability of the accelerated experiments at 55°C. The accelerated test method was also successfully able to distinguish the in vitro product performance between the three batches having varying morphology (process variants), indicating that it is a suitable QC tool to discriminate product or process variants in clinical or commercial batches of microspheres. Additionally, data analysis utilized the MWE to further quantify the differences obtained from the accelerated in vitro product performance test between process variants, thereby enhancing the discriminatory power of the accelerated methodology at 55°C. PMID:24519488

  10. Agricultural biological reference materials for analytical quality control

    SciTech Connect

    Ihnat, M.

    1986-01-01

    Cooperative work is under way at Agriculture Canada, US Department of Agriculture, and US National Bureau of Standards in an attempt to fill some of the gaps in the world repertoire of reference materials and to provide much needed control materials for laboratories' day to day operations. This undertaking involves the preparation and characterization of a number of agricultural and food materials for data quality control for inorganic constituents. Parameters considered in the development of these materials were material selection based on importance in commerce and analysis; techniques of preparation, processing, and packaging; physical and chemical characterization; homogeneity testing and quantitation (certification). A large number of agricultural/food products have been selected to represent a wide range of not only levels of sought-for constituents (elements) but also a wide range of matrix components such as protein, carbohydrate, dietary fiber, fat, and ash. Elements whose concentrations are being certified cover some two dozen major, minor, and trace elements of nutritional, toxicological, and environmental significance.

  11. Statistical Process Control: Going to the Limit for Quality.

    ERIC Educational Resources Information Center

    Training, 1987

    1987-01-01

    Defines the concept of statistical process control, a quality control method used especially in manufacturing. Generally, concept users set specific standard levels that must be met. Makes the point that although employees work directly with the method, management is responsible for its success within the plant. (CH)

  12. Silicon Sheet Quality is Improved By Meniscus Control

    NASA Technical Reports Server (NTRS)

    Yates, D. A.; Hatch, A. E.; Goldsmith, J. M.

    1983-01-01

    Better quality silicon crystals for solar cells are possible with instrument that monitors position of meniscus as sheet of solid silicon is drawn from melt. Using information on meniscus height, instrument generates feedback signal to control melt temperature. Automatic control ensures more uniform silicon sheets.

  13. CRN5EXP: Expert system for statistical quality control

    NASA Technical Reports Server (NTRS)

    Hentea, Mariana

    1991-01-01

    The purpose of the Expert System CRN5EXP is to assist in checking the quality of the coils at two very important mills: Hot Rolling and Cold Rolling in a steel plant. The system interprets the statistical quality control charts, diagnoses and predicts the quality of the steel. Measurements of process control variables are recorded in a database and sample statistics such as the mean and the range are computed and plotted on a control chart. The chart is analyzed through patterns using the C Language Integrated Production System (CLIPS) and a forward chaining technique to reach a conclusion about the causes of defects and to take management measures for the improvement of the quality control techniques. The Expert System combines the certainty factors associated with the process control variables to predict the quality of the steel. The paper presents the approach to extract data from the database, the reason to combine certainty factors, the architecture and the use of the Expert System. However, the interpretation of control charts patterns requires the human expert's knowledge and lends to Expert Systems rules.

  14. Operational and research aspects of a radio-controlled model flight test program

    NASA Technical Reports Server (NTRS)

    Budd, Gerald D.; Gilman, Ronald L.; Eichstedt, David

    1993-01-01

    The operational and research aspects of a subscale, radio-controlled model flight test program are presented. By using low-cost free-flying models, an approach was developed for obtaining research-quality vehicle performance and aerodynamic information. The advantages and limitations learned by applying this approach to a specific flight test program are described. The research quality of the data acquired shows that model flight testing is practical for obtaining consistent repeatable flight data.

  15. Operational and research aspects of a radio-controlled model flight test program

    NASA Technical Reports Server (NTRS)

    Budd, Gerald D.; Gilman, Ronald L.; Eichstedt, David

    1993-01-01

    The operational and research aspects of a subscale, radio-controlled model flight test program are presented. By using low-cost free-flying models, an approach was developed for obtaining research-quality vehicle performance and aerodynamic information. The advantages and limitations learned by applying this approach to a specific flight test program are described. The research quality of the data acquired shows that model flight testing is practical for obtaining consistent and repeatable flight data.

  16. Paper Test Cards for Presumptive Testing of Very Low Quality Antimalarial Medications

    PubMed Central

    Weaver, Abigail A.; Lieberman, Marya

    2015-01-01

    Carrying out chemical analysis of antimalarials to detect low-quality medications before they reach a patient is a costly venture. Here, we show that a library of chemical color tests embedded on a paper card can presumptively identify formulations corresponding to very low quality antimalarial drugs. The presence or absence of chloroquine (CQ), doxycycline (DOX), quinine, sulfadoxine, pyrimethamine, and primaquine antimalarial medications, in addition to fillers used in low-quality pharmaceuticals, are indicated by patterns of colors that are generated on the test cards. Test card sensitivity for detection of these pure components ranges from 90% to 100% with no false positives in the absence of pharmaceutical. The color intensities from reactions characteristic of CQ or DOX allowed visual detection of formulations of these medications cut with 60% or 100% filler, although samples cut with 30% filler could not be reliably detected colorimetrically. However, the addition of unexpected fillers, even in 30% quantities, or substitute pharmaceuticals, could sometimes be detected by other color reactions on the test cards. Tests are simple and inexpensive enough to be carried out in clinics, pharmacies, and ports of entry and could provide a screening method to presumptively indicate very low quality medicines throughout the supply chain. PMID:25897064

  17. Paper test cards for presumptive testing of very low quality antimalarial medications.

    PubMed

    Weaver, Abigail A; Lieberman, Marya

    2015-06-01

    Carrying out chemical analysis of antimalarials to detect low-quality medications before they reach a patient is a costly venture. Here, we show that a library of chemical color tests embedded on a paper card can presumptively identify formulations corresponding to very low quality antimalarial drugs. The presence or absence of chloroquine (CQ), doxycycline (DOX), quinine, sulfadoxine, pyrimethamine, and primaquine antimalarial medications, in addition to fillers used in low-quality pharmaceuticals, are indicated by patterns of colors that are generated on the test cards. Test card sensitivity for detection of these pure components ranges from 90% to 100% with no false positives in the absence of pharmaceutical. The color intensities from reactions characteristic of CQ or DOX allowed visual detection of formulations of these medications cut with 60% or 100% filler, although samples cut with 30% filler could not be reliably detected colorimetrically. However, the addition of unexpected fillers, even in 30% quantities, or substitute pharmaceuticals, could sometimes be detected by other color reactions on the test cards. Tests are simple and inexpensive enough to be carried out in clinics, pharmacies, and ports of entry and could provide a screening method to presumptively indicate very low quality medicines throughout the supply chain. PMID:25897064

  18. [Analysis of the results of the SEIMC External Quality Control Program. Year 2013].

    PubMed

    de Gopegui Bordes, Enrique Ruiz; Orta Mira, Nieves; Del Remedio Guna Serrano, M; Medina González, Rafael; Rosario Ovies, María; Poveda, Marta; Gimeno Cardona, Concepción

    2015-07-01

    The External Quality Control Program of the Spanish Society of Infectious Diseases and Clinical Microbiology (SEIMC) include controls for bacteriology, serology, mycology, parasitology, mycobacteria, virology, molecular microbiology and HIV-1, HCV and HBV viral loads. This manuscript presents the analysis of results obtained of the participants from the 2013 SEIMC External Quality Control Programme, except viral loads controls, that they are summarized in a manuscript abroad. As a whole, the results obtained in 2013 confirm the excellent skill and good technical standards found in previous editions. However, erroneous results can be obtained in any laboratory and in clinically relevant determinations. Once again, the results of this program highlighted the need to implement both internal and external controls in order to assure the maximal quality of the microbiological tests. PMID:26320989

  19. The impact of quality control in RNA-seq experiments

    NASA Astrophysics Data System (ADS)

    Merino, Gabriela A.; Fresno, Cristóbal; Netto, Frederico; Dias Netto, Emmanuel; Pratto, Laura; Fernández, Elmer A.

    2016-04-01

    High throughput mRNA sample sequencing, known as RNA-seq, is as a powerful approach to detect differentially expressed genes starting from millions of short sequence reads. Although several workflows have been proposed to analyze RNA-seq data, the experiment quality control as a whole is not usually considered, thus potentially biasing the results and/or causing information lost. Experiment quality control refers to the analysis of the experiment as a whole, prior to any analysis. It not only inspects the presence of technical effects, but also if general biological assumptions are fulfilled. In this sense, multivariate approaches are crucial for this task. Here, a multivariate approach for quality control in RNA-seq experiments is proposed. This approach uses simple and yet effective well-known statistical methodologies. In particular, Principal Component Analysis was successfully applied over real data to detect and remove outlier samples. In addition, traditional multivariate exploration tools were applied in order to asses several controls that can help to ensure the results quality. Based on differential expression and functional enrichment analysis, here is demonstrated that the information retrieval is significantly enhanced through experiment quality control. Results show that the proposed multivariate approach increases the information obtained from RNA-seq data after outlier samples removal.

  20. Oxidative stress and mitochondrial protein quality control in aging.

    PubMed

    Lionaki, Eirini; Tavernarakis, Nektarios

    2013-10-30

    Mitochondrial protein quality control incorporates an elaborate network of chaperones and proteases that survey the organelle for misfolded or unfolded proteins and toxic aggregates. Repair of misfolded or aggregated protein and proteolytic removal of irreversibly damaged proteins are carried out by the mitochondrial protein quality control system. Initial maturation and folding of the nuclear or mitochondrial-encoded mitochondrial proteins are mediated by processing peptidases and chaperones that interact with the protein translocation machinery. Mitochondrial proteins are subjected to cumulative oxidative damage. Thus, impairment of quality control processes may cause mitochondrial dysfunction. Aging has been associated with a marked decline in the effectiveness of mitochondrial protein quality control. Here, we present an overview of the chaperones and proteases involved in the initial folding and maturation of new, incoming precursor molecules, and the subsequent repair and removal of oxidized aggregated proteins. In addition, we highlight the link between mitochondrial protein quality control mechanisms and the aging process. This article is part of a Special Issue entitled: Posttranslational Protein modifications in biology and Medicine. PMID:23563202