Unraveling the Complexity of Critical Consciousness, Political Efficacy, and Political Action Among Marginalized Adolescents.

PubMed

Diemer, Matthew A; Rapa, Luke J

2016-01-01

This research examines the complex patterns by which distinct dimensions of critical consciousness may lead marginalized adolescents toward distinct forms of political action. Structural equation modeling was applied to nationally representative data from the Civic Education Study (2,811 ninth graders; Mage  = 14.6), first establishing the measurement invariance of constructs across samples of poor or working class African American and Latino/a adolescents. Perceptions of societal inequality and aspirational beliefs that society ought to be more equal differentially predicted expected voting, conventional political action, and social action-while controlling for civic achievement and with nuances between ethnic and racial groups. Contrary to hypotheses and extant scholarship, political efficacy did not mediate or moderate relations between critical reflection and disparate forms of political action. © 2015 The Authors. Child Development © 2015 Society for Research in Child Development, Inc.

Accuracy of HIV-related risk behaviors reported by female sex workers, Iran: a method to quantify measurement bias in marginalized populations.

PubMed

Mirzazadeh, Ali; Haghdoost, Ali Akbar; Nedjat, Saharnaz; Navadeh, Soodabeh; McFarland, Willi; Mohammad, Kazem

2013-02-01

We quantified discrepancies in reported behaviors of female sex workers (FSW) by comparing 63 face-to-face interviews (FTFI) to in-depth interviews (IDI), with corroboration of the directions and magnitudes of reporting by a panel of psychologists who work with FSW. Sensitivities, specificities, positive and negative predictive values (PPV and NPV) were assessed for FTFI responses using IDI as a "gold standard". Sensitivities were lowest in reporting symptoms of sexually transmitted infections (63.9 %), finding sex partners in venues (52.4 %) and not receiving HIV test results (66.7 %). Specificities (all >83 %) and PPVs (all >74.0 %) were higher than NPV. FSW significantly under-reported number of clients, sexual contacts and non-condom use sex acts with clients and number of days engaging in sex work in the preceding week. This study provides a quantified gauge of reporting biases in FSW behaviors. Such estimates and methods help better understand true HIV risk in marginalized populations and calibrate survey estimates accordingly.

Self-organized critical behavior and marginality in Ising spin glasses

NASA Astrophysics Data System (ADS)

Sharma, Auditya; Yeo, Joonhyun; Moore, M. A.

2018-05-01

We have studied numerically the states reached in a quench from various temperatures in the one-dimensional fully-connected Kotliar, Anderson and Stein Ising spin glass model. This is a model where there are long-range interactions between the spins which falls off as a power σ of their separation. We have made a detailed study in particular of the energies of the states reached in a quench from infinite temperature and their overlaps, including the spin glass susceptibility. In the regime where , where the model is similar to the Sherrington–Kirkpatrick model, we find that the spin glass susceptibility diverges logarithmically with increasing N, the number of spins in the system, whereas for it remains finite. We attribute the behavior for to self-organized critical behavior, where the system after the quench is close to the transition between states which have trivial overlaps and those with the non-trivial overlaps associated with replica symmetry breaking. We have also found by studying the distribution of local fields that the states reached in the quench have marginal stability but only when .

Characterizing entanglement with global and marginal entropic measures

DOE Office of Scientific and Technical Information (OSTI.GOV)

Adesso, Gerardo; Illuminati, Fabrizio; De Siena, Silvio

2003-12-01

We qualify the entanglement of arbitrary mixed states of bipartite quantum systems by comparing global and marginal mixednesses quantified by different entropic measures. For systems of two qubits we discriminate the class of maximally entangled states with fixed marginal mixednesses, and determine an analytical upper bound relating the entanglement of formation to the marginal linear entropies. This result partially generalizes to mixed states the quantification of entanglement with marginal mixednesses holding for pure states. We identify a class of entangled states that, for fixed marginals, are globally more mixed than product states when measured by the linear entropy. Such statesmore » cannot be discriminated by the majorization criterion.« less

Marginal kidney donor

PubMed Central

Gopalakrishnan, Ganesh; Gourabathini, Siva Prasad

2007-01-01

Renal transplantation is the treatment of choice for a medically eligible patient with end stage renal disease. The number of renal transplants has increased rapidly over the last two decades. However, the demand for organs has increased even more. This disparity between the availability of organs and waitlisted patients for transplants has forced many transplant centers across the world to use marginal kidneys and donors. We performed a Medline search to establish the current status of marginal kidney donors in the world. Transplant programs using marginal deceased renal grafts is well established. The focus is now on efforts to improve their results. Utilization of non-heart-beating donors is still in a plateau phase and comprises a minor percentage of deceased donations. The main concern is primary non-function of the renal graft apart from legal and ethical issues. Transplants with living donors outnumbered cadaveric transplants at many centers in the last decade. There has been an increased use of marginal living kidney donors with some acceptable medical risks. Our primary concern is the safety of the living donor. There is not enough scientific data available to quantify the risks involved for such donation. The definition of marginal living donor is still not clear and there are no uniform recommendations. The decision must be tailored to each donor who in turn should be actively involved at all levels of the decision-making process. In the current circumstances, our responsibility is very crucial in making decisions for either accepting or rejecting a marginal living donor. PMID:19718332

Quantifying 10Be-derived Erosion Rates from the Min Shan in the Eastern Margin of the Tibetan Plateau

NASA Astrophysics Data System (ADS)

Kirkpatrick, H.; Moon, S.; Harrison, M.; Yin, A.

2017-12-01

Spatial and temporal variations of long-term erosion rates can provide fundamental insights into the topographic and tectonic development of Eastern Tibet. Previous studies have quantified erosion rates at thousand to million-year-timescales in the central and northern Longmen Shan region with a view of understanding the locally complex tectonic interactions. However, it is still unclear how the magnitude, rate, and style of tectonic deformation vary across the eastern margin of the Tibetan Plateau. In this study, we examine the erosional history and topographic development of the Min Shan, located north of the Longmen Shan and west of Sichuan basin. Over a distance of 50 km, elevations increase from 500 m in Sichuan Basin to a peak of 5600 m in the west. The eastern portion of our study area is a foreland thrust belt with relatively flat topography, while the western portion contains deformed silicic sedimentary strata with steep slopes and a topographic relief of >2000 m. In this study, we use cosmogenic 10Be from river sands to measure thousand-year-timescale erosion rates of 12 catchments across the Min Shan. We then compare these rates with published million-year-timescale exhumation rates from apatite and zircon (U-Th)/He and apatite and zircon fission track thermochronometers. These data should lead us to a better understanding of the spatial and temporal variations of deformation throughout the eastern Tibetan margin and help discern the relative effects of climate and tectonics in forming Himlayan landscapes.

Cascadia Gas Vent Distribution and Challenges to Quantify Margin-Wide Methane Fluxes

NASA Astrophysics Data System (ADS)

Scherwath, M.; Riedel, M.; Roemer, M.; Veloso, M.; Heesemann, M.; Spence, G.

2017-12-01

Gas venting along the Cascadia Margin has been mapped over decades with ship sonar and in recent years with permanent seafloor installations utilizing the seafloor observatories NEPTUNE of Ocean Networks Canada and the Cabled Array of the Ocean Observatories Initiative. We show the distribution of over 1000 vents, most on the shallow shelf. For a third of the vents we have estimated methane flow rates, ranging from 0.05 to 69 L/min, and extrapolate these results to a margin-wide methane flow estaimate of around 4 Mt/yr (at surface pressure and temperature) and a flux estimate of 0.05 kg yr-1 m-2. However, these estimates are based on several assumptions, e.g. bubble sizes or data coverage, providing large uncertainties. With continued research expeditions and potential seafloor calibration experiments, these data can be refined and improved in future years.

Plutonium Critical Mass Curve Comparison to Mass at Upper Subcritical Limit (USL) Using Whisper

DOE Office of Scientific and Technical Information (OSTI.GOV)

Alwin, Jennifer Louise; Zhang, Ning

Whisper is computational software designed to assist the nuclear criticality safety analyst with validation studies with the MCNP ® Monte Carlo radiation transport package. Standard approaches to validation rely on the selection of benchmarks based upon expert judgment. Whisper uses sensitivity/uncertainty (S/U) methods to select relevant benchmarks to a particular application or set of applications being analyzed. Using these benchmarks, Whisper computes a calculational margin. Whisper attempts to quantify the margin of subcriticality (MOS) from errors in software and uncertainties in nuclear data. The combination of the Whisper-derived calculational margin and MOS comprise the baseline upper subcritical limit (USL), tomore » which an additional margin may be applied by the nuclear criticality safety analyst as appropriate to ensure subcriticality. A series of critical mass curves for plutonium, similar to those found in Figure 31 of LA-10860-MS, have been generated using MCNP6.1.1 and the iterative parameter study software, WORM_Solver. The baseline USL for each of the data points of the curves was then computed using Whisper 1.1. The USL was then used to determine the equivalent mass for plutonium metal-water system. ANSI/ANS-8.1 states that it is acceptable to use handbook data, such as the data directly from the LA-10860-MS, as it is already considered validated (Section 4.3 4) “Use of subcritical limit data provided in ANSI/ANS standards or accepted reference publications does not require further validation.”). This paper attempts to take a novel approach to visualize traditional critical mass curves and allows comparison with the amount of mass for which the k eff is equal to the USL (calculational margin + margin of subcriticality). However, the intent is to plot the critical mass data along with USL, not to suggest that already accepted handbook data should have new and more rigorous requirements for validation.« less

Quantifying the Evolution of Melt Ponds in the Marginal Ice Zone Using High Resolution Optical Imagery and Neural Networks

NASA Astrophysics Data System (ADS)

Ortiz, M.; Pinales, J. C.; Graber, H. C.; Wilkinson, J.; Lund, B.

2016-02-01

Melt ponds on sea ice play a significant and complex role on the thermodynamics in the Marginal Ice Zone (MIZ). Ponding reduces the sea ice's ability to reflect sunlight, and in consequence, exacerbates the albedo positive feedback cycle. In order to understand how melt ponds work and their effect on the heat uptake of sea ice, we must quantify ponds through their seasonal evolution first. A semi-supervised neural network three-class learning scheme using a gradient descent with momentum and adaptive learning rate backpropagation function is applied to classify melt ponds/melt areas in the Beaufort Sea region. The network uses high resolution panchromatic satellite images from the MEDEA program, which are collocated with autonomous platform arrays from the Marginal Ice Zone Program, including ice mass-balance buoys, arctic weather stations and wave buoys. The goal of the study is to capture the spatial variation of melt onset and freeze-up of the ponds within the MIZ, and gather ponding statistics such as size and concentration. The innovation of this work comes from training the neural network as the melt ponds evolve over time; making the machine learning algorithm time-dependent, which has not been previously done. We will achieve this by analyzing the image histograms through quantification of the minima and maxima intensity changes as well as linking textural variation information of the imagery. We will compare the evolution of the melt ponds against several different array sites on the sea ice to explore if there are spatial differences among the separated platforms in the MIZ.

Marginal states in a cubic autocatalytic reaction

NASA Astrophysics Data System (ADS)

Das, Debojyoti; Ghosh, Pushpita; Ray, Deb Shankar

2011-09-01

Marginal steady state belongs to a special class of states in nonlinear dynamics. To realize this state we consider a cubic autocatalytic reaction A + 2B → 3B in a continuous-stirred-tank-reactor, where the flow rate of the reactant A can be controlled to manipulate the dynamical behavior of the open system. We demonstrate that when the flow rate is weakly noisy the autocatalytic reaction admits of a steady state which is marginal in nature and is surrounded by infinite number of periodic trajectories. When the uncatalyzed reaction A → B is included in the reaction scheme, there exists a marginal steady state which is a critical state corresponding to the point of transition between the flow branch and the equilibrium branch, similar to gas-liquid critical point of transition. This state loses its stability in the weak noise limit.

Hierarchical Marginal Land Assessment for Land Use Planning

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kang, Shujiang; Post, Wilfred M; Wang, Dali

2013-01-01

Marginal land provides an alternative potential for food and bioenergy production in the face of limited land resources; however, effective assessment of marginal lands is not well addressed. Concerns over environmental risks, ecosystem services and sustainability for marginal land have been widely raised. The objective of this study was to develop a hierarchical marginal land assessment framework for land use planning and management. We first identified major land functions linking production, environment, ecosystem services and economics, and then classified land resources into four categories of marginal land using suitability and limitations associated with major management goals, including physically marginal land,more » biologically marginal land, environmental-ecological marginal land, and economically marginal land. We tested this assessment framework in south-western Michigan, USA. Our results indicated that this marginal land assessment framework can be potentially feasible on land use planning for food and bioenergy production, and balancing multiple goals of land use management. We also compared our results with marginal land assessment from the Conservation Reserve Program (CRP) and land capability classes (LCC) that are used in the US. The hierarchical assessment framework has advantages of quantitatively reflecting land functions and multiple concerns. This provides a foundation upon which focused studies can be identified in order to improve the assessment framework by quantifying high-resolution land functions associated with environment and ecosystem services as well as their criteria are needed to improve the assessment framework.« less

Safety margins in older adults increase with improved control of a dynamic object

PubMed Central

Hasson, Christopher J.; Sternad, Dagmar

2014-01-01

Older adults face decreasing motor capabilities due to pervasive neuromuscular degradations. As a consequence, errors in movement control increase. Thus, older individuals should maintain larger safety margins than younger adults. While this has been shown for object manipulation tasks, several reports on whole-body activities, such as posture and locomotion, demonstrate age-related reductions in safety margins. This is despite increased costs for control errors, such as a fall. We posit that this paradox could be explained by the dynamic challenge presented by the body or also an external object, and that age-related reductions in safety margins are in part due to a decreased ability to control dynamics. To test this conjecture we used a virtual ball-in-cup task that had challenging dynamics, yet afforded an explicit rendering of the physics and safety margin. The hypotheses were: (1) When manipulating an object with challenging dynamics, older adults have smaller safety margins than younger adults. (2) Older adults increase their safety margins with practice. Nine young and 10 healthy older adults practiced moving the virtual ball-in-cup to a target location in exactly 2 s. The accuracy and precision of the timing error quantified skill, and the ball energy relative to an escape threshold quantified the safety margin. Compared to the young adults, older adults had increased timing errors, greater variability, and decreased safety margins. With practice, both young and older adults improved their ability to control the object with decreased timing errors and variability, and increased their safety margins. These results suggest that safety margins are related to the ability to control dynamics, and may explain why in tasks with simple dynamics older adults use adequate safety margins, but in more complex tasks, safety margins may be inadequate. Further, the results indicate that task-specific training may improve safety margins in older adults. PMID:25071566

Post-resection mucosal margin shrinkage in oral cancer: quantification and significance.

PubMed

Mistry, Rajesh C; Qureshi, Sajid S; Kumaran, C

2005-08-01

The importance of tumor free margins in outcome of cancer surgery is well known. Often the pathological margins are reported to be significantly smaller than the in situ margins. This discrepancy is due to margin shrinkage the quantum of which has not been studied in patients with oral cancers. To quantify the shrinkage of mucosal margin following excision for carcinoma of the oral tongue and buccal mucosa. Mucosal margins were measured prior to resection and half an hour after excision in 27 patients with carcinoma of the tongue and buccal mucosa. The mean margin shrinkage was assessed and the variables affecting the quantum of shrinkage analyzed. The mean shrinkage from the in situ to the post resection margin status was 22.7% (P < 0.0001). The mean shrinkage of the tongue margins was 23.5%, compared to 21.2% for buccal mucosa margins. The mean shrinkage in T1/T2 tumors (25.6%) was significantly more than in T3/T4 (9.2%, P < 0.011). There is significant shrinkage of mucosal margins after surgery. Hence this should be considered and appropriate margins should be taken at initial resection to prevent the agony of post-operative positive surgical margins. Copyright 2005 Wiley-Liss, Inc.

Beyond Diversity as Usual: Expanding Critical Cultural Approaches to Marginalization in Engineering Education

ERIC Educational Resources Information Center

Secules, Stephen

2017-01-01

In general, what we think of as "diversity work" in undergraduate engineering education focuses in the following ways: more on the overlooked assets of minority groups than on the acts of overlooking, more on the experiences of marginalized groups than on the mechanisms of marginalization by dominant groups, more on supporting and…

Effect of posterior crown margin placement on gingival health.

PubMed

Reitemeier, Bernd; Hänsel, Kristina; Walter, Michael H; Kastner, Christian; Toutenburg, Helge

2002-02-01

The clinical impact of posterior crown margin placement on gingival health has not been thoroughly quantified. This study evaluated the effect of posterior crown margin placement with multivariate analysis. Ten general dentists reviewed 240 patients with 480 metal-ceramic crowns in a prospective clinical trial. The alloy was randomly selected from 2 high gold, 1 low gold, and 1 palladium alloy. Variables were the alloy used, oral hygiene index score before treatment, location of crown margins at baseline, and plaque index and sulcus bleeding index scores recorded for restored and control teeth after 1 year. The effect of crown margin placement on sulcular bleeding and plaque accumulation was analyzed with regression models (P<.05). The probability of plaque at 1 year increased with increasing oral hygiene index score before treatment. The lingual surfaces demonstrated the highest probability of plaque. The risk of bleeding at intrasulcular posterior crown margins was approximately twice that at supragingival margins. Poor oral hygiene before treatment and plaque also were associated with sulcular bleeding. Facial sites exhibited a lower probability of sulcular bleeding than lingual surfaces. Type of alloy did not influence sulcular bleeding. In this study, placement of crown margins was one of several parameters that affected gingival health.

Geomorphic characterization of the U.S. Atlantic continental margin

USGS Publications Warehouse

Brothers, Daniel S.; ten Brink, Uri S.; Andrews, Brian D.; Chaytor, Jason D.

2013-01-01

The increasing volume of multibeam bathymetry data collected along continental margins is providing new opportunities to study the feedbacks between sedimentary and oceanographic processes and seafloor morphology. Attempts to develop simple guidelines that describe the relationships between form and process often overlook the importance of inherited physiography in slope depositional systems. Here, we use multibeam bathymetry data and seismic reflection profiles spanning the U.S. Atlantic outer continental shelf, slope and rise from Cape Hatteras to New England to quantify the broad-scale, across-margin morphological variation. Morphometric analyses suggest the margin can be divided into four basic categories that roughly align with Quaternary sedimentary provinces. Within each category, Quaternary sedimentary processes exerted heavy modification of submarine canyons, landslide complexes and the broad-scale morphology of the continental rise, but they appear to have preserved much of the pre-Quaternary, across-margin shape of the continental slope. Without detailed constraints on the substrate structure, first-order morphological categorization the U.S. Atlantic margin does not provide a reliable framework for predicting relationships between form and process.

Strategies for managing margins.

PubMed

2012-08-01

Potential Medicare and Medicaid reimbursement cuts have made it critical for home health agencies to manage their gross and net operating profit margins. Agencies need to develop tools to analyze their margins and make sure they are following best practices. Try as you may, your agency might still face the question, "Why am I not meeting my budget?" Get some answers in this session from David Berman and Andrea L. Devoti. Berman is a principal at Simione Healthcare Consultants in Hamden, CT, where he is responsible for merchant acquisitions, business valuation due diligence, and oversight of the financial monitor benchmarking tool besides serving as interim chief financial officer. Devoti is chairman of the NAHC board and President & CEO of Neighborhood Health Visiting Nurse Association in West Chester PA.

Quantifying trail erosion and stream sedimentation with sediment tracers

Treesearch

Mark S. Riedel

2006-01-01

Abstract--The impacts of forest disturbance and roads on stream sedimentation have been rigorously investigated and documented. While historical research on turbidity and suspended sediments has been thorough, studies of stream bed sedimentation have typically relied on semi-quantitative measures such as embeddedness or marginal pool depth. To directly quantify the...

Experimentally quantifying critical stresses associated with basal slip and twinning in magnesium using micro-pillars

DOE PAGES

Liu, Yue; Li, Nan; Mariyappan, Arul Kumar; ...

2017-06-07

Basal slip and {01more » $$\\bar{1}$$2} twinning are two major plastic deformation mechanisms in hexagonal closed-packed magnesium. Here in this paper, we quantify the critical stresses associated with basal slip and twinning in single-crystal and bi-crystal magnesium samples by performing in situ compression of micropillars with different diameters in a scanning electron microscope. The micropillars are designed to favor either slip or twinning under uniaxial compression. Compression tests imply a negligible size effect related to basal slip and twinning as pillar diameter is greater than 10 μm. The critical resolved shear stresses are deduced to be 29 MPa for twinning and 6 MPa for basal slip from a series of micropillar compression tests. Employing full-field elasto-visco-plastic simulations, we further interpret the experimental observations in terms of the local stress distribution associated with multiple twinning, twin nucleation, and twin growth. Our simulation results suggest that the twinning features being studied should not be close to the top surface of the micropillar because of local stress perturbations induced by the hard indenter.« less

Ku band airborne radar altimeter observations of marginal sea ice during the 1984 Marginal Ice Zone Experiment

NASA Technical Reports Server (NTRS)

Drinkwater, Mark R.

1991-01-01

Pulse-limited, airborne radar data taken in June and July 1984 with a 13.8-GHz altimeter over the Fram Strait marginal ice zone are analyzed with the aid of large-format aerial photography, airborne synthetic aperture radar data, and surface observations. Variations in the radar return pulse waveforms are quantified and correlated with ice properties recorded during the Marginal Ice Zone Experiment. Results indicate that the wide-beam altimeter is a flexible instrument, capable of identifying the ice edge with a high degree of accuracy, calculating the ice concentration, and discriminating a number of different ice classes. This suggests that microwave radar altimeters have a sensitivity to sea ice which has not yet been fully exploited. When fused with SSM/I, AVHRR and ERS-1 synthetic aperture radar imagery, future ERS-1 altimeter data are expected to provide some missing pieces to the sea ice geophysics puzzle.

Reclaiming Power and Identity: Marginalized Students' Experiences of Service-Learning

ERIC Educational Resources Information Center

Winans-Solis, Jaime

2014-01-01

This qualitative case study investigates how service-learning may enable self-direction and the development of a critical consciousness for marginalized high school students by exploring the dynamics of service-learning through a theoretical framework of critical theory. Service-learning is theorized to counter the oppressive nature of schooling…

Marginalization in neural circuits with divisive normalization

PubMed Central

Beck, J.M.; Latham, P.E.; Pouget, A.

2011-01-01

A wide range of computations performed by the nervous system involves a type of probabilistic inference known as marginalization. This computation comes up in seemingly unrelated tasks, including causal reasoning, odor recognition, motor control, visual tracking, coordinate transformations, visual search, decision making, and object recognition, to name just a few. The question we address here is: how could neural circuits implement such marginalizations? We show that when spike trains exhibit a particular type of statistics – associated with constant Fano factors and gain-invariant tuning curves, as is often reported in vivo – some of the more common marginalizations can be achieved with networks that implement a quadratic nonlinearity and divisive normalization, the latter being a type of nonlinear lateral inhibition that has been widely reported in neural circuits. Previous studies have implicated divisive normalization in contrast gain control and attentional modulation. Our results raise the possibility that it is involved in yet another, highly critical, computation: near optimal marginalization in a remarkably wide range of tasks. PMID:22031877

A soft-contact model for computing safety margins in human prehension.

PubMed

Singh, Tarkeshwar; Ambike, Satyajit

2017-10-01

The soft human digit tip forms contact with grasped objects over a finite area and applies a moment about an axis normal to the area. These moments are important for ensuring stability during precision grasping. However, the contribution of these moments to grasp stability is rarely investigated in prehension studies. The more popular hard-contact model assumes that the digits exert a force vector but no free moment on the grasped object. Many sensorimotor studies use this model and show that humans estimate friction coefficients to scale the normal force to grasp objects stably, i.e. the smoother the surface, the tighter the grasp. The difference between the applied normal force and the minimal normal force needed to prevent slipping is called safety margin and this index is widely used as a measure of grasp planning. Here, we define and quantify safety margin using a more realistic contact model that allows digits to apply both forces and moments. Specifically, we adapt a soft-contact model from robotics and demonstrate that the safety margin thus computed is a more accurate and robust index of grasp planning than its hard-contact variant. Previously, we have used the soft-contact model to propose two indices of grasp planning that show how humans account for the shape and inertial properties of an object. A soft-contact based safety margin offers complementary insights by quantifying how humans may account for surface properties of the object and skin tissue during grasp planning and execution. Copyright © 2017 Elsevier B.V. All rights reserved.

Reinforcing marginality? Maternal health interventions in rural Nicaragua.

PubMed

Kvernflaten, Birgit

2017-06-23

To achieve Millennium Development Goal 5 on maternal health, many countries have focused on marginalized women who lack access to care. Promoting facility-based deliveries to ensure skilled birth attendance and emergency obstetric care has become a main measure for preventing maternal deaths, so women who opt for home births are often considered 'marginal' and in need of targeted intervention. Drawing upon ethnographic data from Nicaragua, this paper critically examines the concept of marginality in the context of official efforts to increase institutional delivery amongst the rural poor, and discusses lack of access to health services among women living in peripheral areas as a process of marginalization. The promotion of facility birth as the new norm, in turn, generates a process of 're-marginalization', whereby public health officials morally disapprove of women who give birth at home, viewing them as non-compliers and a problem to the system. In rural Nicaragua, there is a discrepancy between the public health norm and women's own preferences and desires for home birth. These women live at the margins also in spatial and societal terms, and must relate to a health system they find incapable of providing good, appropriate care. Strong public pressure for institutional delivery makes them feel distressed and pressured. Paradoxically then, the aim of including marginal groups in maternal health programmes engenders resistance to facility birth.

PTV margin determination in conformal SRT of intracranial lesions

PubMed Central

Parker, Brent C.; Shiu, Almon S.; Maor, Moshe H.; Lang, Frederick F.; Liu, H. Helen; White, R. Allen; Antolak, John A.

2002-01-01

The planning target volume (PTV) includes the clinical target volume (CTV) to be irradiated and a margin to account for uncertainties in the treatment process. Uncertainties in miniature multileaf collimator (mMLC) leaf positioning, CT scanner spatial localization, CT‐MRI image fusion spatial localization, and Gill‐Thomas‐Cosman (GTC) relocatable head frame repositioning were quantified for the purpose of determining a minimum PTV margin that still delivers a satisfactory CTV dose. The measured uncertainties were then incorporated into a simple Monte Carlo calculation for evaluation of various margin and fraction combinations. Satisfactory CTV dosimetric criteria were selected to be a minimum CTV dose of 95% of the PTV dose and at least 95% of the CTV receiving 100% of the PTV dose. The measured uncertainties were assumed to be Gaussian distributions. Systematic errors were added linearly and random errors were added in quadrature assuming no correlation to arrive at the total combined error. The Monte Carlo simulation written for this work examined the distribution of cumulative dose volume histograms for a large patient population using various margin and fraction combinations to determine the smallest margin required to meet the established criteria. The program examined 5 and 30 fraction treatments, since those are the only fractionation schemes currently used at our institution. The fractionation schemes were evaluated using no margin, a margin of just the systematic component of the total uncertainty, and a margin of the systematic component plus one standard deviation of the total uncertainty. It was concluded that (i) a margin of the systematic error plus one standard deviation of the total uncertainty is the smallest PTV margin necessary to achieve the established CTV dose criteria, and (ii) it is necessary to determine the uncertainties introduced by the specific equipment and procedures used at each institution since the uncertainties may vary

A method for identifying EMI critical circuits during development of a large C3

NASA Astrophysics Data System (ADS)

Barr, Douglas H.

The circuit analysis methods and process Boeing Aerospace used on a large, ground-based military command, control, and communications (C3) system are described. This analysis was designed to help identify electromagnetic interference (EMI) critical circuits. The methodology used the MIL-E-6051 equipment criticality categories as the basis for defining critical circuits, relational database technology to help sort through and account for all of the approximately 5000 system signal cables, and Macintosh Plus personal computers to predict critical circuits based on safety margin analysis. The EMI circuit analysis process systematically examined all system circuits to identify which ones were likely to be EMI critical. The process used two separate, sequential safety margin analyses to identify critical circuits (conservative safety margin analysis, and detailed safety margin analysis). These analyses used field-to-wire and wire-to-wire coupling models using both worst-case and detailed circuit parameters (physical and electrical) to predict circuit safety margins. This process identified the predicted critical circuits that could then be verified by test.

Significance of post-resection tissue shrinkage on surgical margins of oral squamous cell carcinoma.

PubMed

El-Fol, Hossam Abdelkader; Noman, Samer Abduljabar; Beheiri, Mohamed Galal; Khalil, Abdalla M; Kamel, Mahmoud Mohamed

2015-05-01

Resecting oral squamous cell carcinoma (SCC) with an appropriate margin of uninvolved tissue is critical in preventing local recurrence and in making decisions regarding postoperative radiation therapy. This task can be difficult due to the discrepancy between margins measured intraoperatively and those measured microscopically by the pathologist after specimen processing. A total of 61 patients underwent resective surgery with curative intent for primary oral SCC were included in this study. All patients underwent resection of the tumor with a measured 1-cm margin. Specimens were then submitted for processing and reviewing, and histopathologic margins were measured. The closest histopathologic margin was compared with the in situ margin (1 cm) to determine the percentage discrepancy. The mean discrepancy between the in situ margins and the histopathological margins of all close and positive margins were 47.6% for the buccal mucosa (with a P value corresponding to 0.05 equaling 2.1), which is statistically significant, 4.8% for the floor of mouth, 9.5% for the mandibular alveolus, 4.8% for the retromolar trigon, and 33.3% for the tongue. There is a significant difference among resection margins based on tumor anatomical location. Margins shrinkage after resection and processing should be considered at the time of the initial resection. Tumors located in the buccal mucosa show significantly greater discrepancies than tumors at other sites. These findings suggest that it is critical to consider the oral site when outlining margins to ensure adequacy of resection. Buccal SCC is an aggressive disease, and should be considered as an aggressive subsite within the oral cavity, requiring a radical and aggressive resective approach. Copyright © 2015 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved.

A Kairos of the Critical: Teaching Critically in a Time of Compliance

ERIC Educational Resources Information Center

Drabinski, Emily

2017-01-01

The promise of critical pedagogy lies in its capacity to change lives as librarians try new ways of thinking and teaching that challenge systems of power that privilege some and not others. In the last ten years, critical pedagogy has moved from the margins to the center, most clearly in its influence on the new "Framework for Information…

NF-κB deregulation in splenic marginal zone lymphoma.

PubMed

Spina, Valeria; Rossi, Davide

2016-08-01

Splenic marginal zone lymphoma is a rare mature B-cell malignancy involving the spleen, bone marrow and blood. Over the past years, the rapid expansion of sequencing technologies allowing the genome-wide assessment of genomic, epigenetic and transcriptional changes has revolutionized our understanding of the biological basis of splenic marginal zone lymphoma by providing a comprehensive and unbiased view of the genes/pathways that are deregulated in this disease. NF-κB is a family of transcription factors that plays critical roles in development, survival, and activation of B lymphocytes. Consistent with the physiological involvement of NF-κB signalling in proliferation and commitment of mature B-cells to the marginal zone of the spleen, many oncogenic mutations involved in constitutive activation of the NF-κB pathway were recently identified in splenic marginal zone lymphoma. This review describes the progress in understanding the mechanism of NF-κB activation in splenic marginal zone lymphoma, including molecular, epigenetic and post-transcriptional modifications of NF-κB genes and of upstream pathways, and discusses how information gained from these efforts has provided new insights on potential targets of diagnostic, prognostic and therapeutic relevance for splenic marginal zone lymphoma. Copyright © 2016. Published by Elsevier Ltd.

SU-F-J-102: Lower Esophagus Margin Implications Based On Rapid Computational Algorithm for SBRT

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cardenas, M; Mazur, T; Li, H

2016-06-15

Purpose: To quantify inter-fraction esophagus-variation. Methods: Computed tomography and daily on-treatment 0.3-T MRI data sets for 7 patients were analyzed using a novel Matlab-based (Mathworks, Natick, MA) rapid computational method. Rigid registration was performed from the cricoid to the gastro-esophageal junction. CT and MR-based contours were compared at slice intervals of 3mm. Variation was quantified by “expansion,” defined as additional length in any radial direction from CT contour to MR contour. Expansion computations were performed with 360° of freedom in each axial slice. We partitioned expansions into left anterior, right anterior, right posterior, and left posterior quadrants (LA, RA, RP,more » and LP, respectively). Sample means were compared by analysis of variance (ANOVA) and Fisher’s Protected Least Significant Difference test. Results: Fifteen fractions and 1121 axial slices from 7 patients undergoing SBRT for primary lung cancer (3) and metastatic lung disease (4) were analyzed, generating 41,970 measurements. Mean LA, RA, RP, and LP expansions were 4.30±0.05 mm, 3.71±0.05mm, 3.17±0.07, and 3.98±0.06mm, respectively. 50.13% of all axial slices showed variation > 5 mm in one or more directions. Variation was greatest in lower esophagus with mean LA, RA, RP, and LP expansion (5.98±0.09 mm, 4.59±0.09 mm, 4.04±0.16 mm, and 5.41±0.16 mm, respectively). The difference was significant compared to mid and upper esophagus (p<.0001). The 95th percentiles of expansion for LA, RA, RP, LP were 13.36 mm, 9.97 mm, 11.29 mm, and 12.19 mm, respectively. Conclusion: Analysis of on-treatment MR imaging of the lower esophagus during thoracic SBRT suggests margin expansions of 13.36 mm LA, 9.97 mm RA, 11.29 mm RP, 12.19 mm LP would account for 95% of measurements. Our novel algorithm for rapid assessment of margin expansion for critical structures with 360° of freedom in each axial slice enables continuously adaptive patient-specific margins

The Ills of Marginality: New Perspectives on Health in South Asia.

PubMed

Ecks, Stefan; Sax, William S

2005-12-01

Social marginality and ill health can form an unholy dyad: firstly, groups who suffer from chronic or infectious diseases often find themselves pushed to the margins. Secondly, people who are already on the edge of society tend to suffer more from illness than those at the centre. In development discourse, marginal people are defined as those who are 'not yet' on the same level as the developed mainstream and are in urgent need of aid from the centre. The papers in this special issue take a different approach by insisting that marginality is a radically relational concept: the centre and its margins constitute each other, and the boundaries between them are constantly shifting. The papers show that there are many types of marginality (based on geography, class, caste, sex/gender, ethnicity, etc.), and that each of them has different effects on the health of a particular group. Yet instead of speaking of a plurality of unrelated 'group identities', marginality preserves a sharp sense of unequal power relations between groups. The specific ethnographic contribution to the study of marginality comes from its attention to the point of view of marginal people. This is of critical importance since marginality puts health most under stress when it is clearly and steadily perceived in everyday life. This, in turn, makes it possible to show that living on the margins is not always and everywhere bad for health. While all of the papers present South Asian case studies, the insights and questions are relevant for the study of the ills of marginality in a global perspective.

Reconstruction of the East Africa and Antarctica continental margins

NASA Astrophysics Data System (ADS)

Nguyen, Luan C.; Hall, Stuart A.; Bird, Dale E.; Ball, Philip J.

2016-06-01

The Early Jurassic separation of Antarctica from Africa plays an important role in our understanding of the dispersal of Gondwana and Pangea. Previous reconstruction models contain overlaps and gaps in the restored margins that reflect difficulties in accurately delineating the continent-ocean-boundary (COB) and determining the amount and distribution of extended continental crust. This study focuses on the evolution of the African margin adjacent to the Mozambique Basin and the conjugate Antarctic margin near the Riiser-Larsen Sea. Satellite-derived gravity data have been used to trace the orientations and landward limits of fracture zones. A 3-D gravity inversion has produced a crustal thickness model that reliably quantifies the extent and amount of stretched crust. Crustal thicknesses together with fracture zone terminations reveal COBs that are significantly closer to the African and Antarctic coasts than previously recognized. Correlation of fracture zone azimuths and identified COBs suggests Antarctica began drifting away from Africa at approximately 171 Ma in a roughly SSE direction. An areal-balancing method has been used to restore the crust to a uniform prerift thickness so as to perform a nonrigid reconstruction for both nonvolcanic and volcanic margins. Both margins reveal a trend of increasing extension from east to west. Our results suggest Africa underwent extension of 60-120 km, while Antarctic crust was stretched by 105-180 km. Various models tested to determine the direction of extension during rifting suggest that Antarctica moved away from Africa in a WNW-ESE direction during the period between 184 and 171 Ma prior to the onset of seafloor spreading.

A simple model for enamel fracture from margin cracks.

PubMed

Chai, Herzl; Lee, James J-W; Kwon, Jae-Young; Lucas, Peter W; Lawn, Brian R

2009-06-01

We present results of in situ fracture tests on extracted human molar teeth showing failure by margin cracking. The teeth are mounted into an epoxy base and loaded with a rod indenter capped with a Teflon insert, as representative of food modulus. In situ observations of cracks extending longitudinally upward from the cervical margins are recorded in real time with a video camera. The cracks appear above some threshold and grow steadily within the enamel coat toward the occlusal surface in a configuration reminiscent of channel-like cracks in brittle films. Substantially higher loading is required to delaminate the enamel from the dentin, attesting to the resilience of the tooth structure. A simplistic fracture mechanics analysis is applied to determine the critical load relation for traversal of the margin crack along the full length of the side wall. The capacity of any given tooth to resist failure by margin cracking is predicted to increase with greater enamel thickness and cuspal radius. Implications in relation to dentistry and evolutionary biology are briefly considered.

Skeletal Muscle Ultrasonography in Nutrition and Functional Outcome Assessment of Critically Ill Children: Experience and Insights From Pediatric Disease and Adult Critical Care Studies [Formula: see text].

PubMed

Ong, Chengsi; Lee, Jan Hau; Leow, Melvin K S; Puthucheary, Zudin A

2017-09-01

Evidence suggests that critically ill children develop muscle wasting, which could affect outcomes. Muscle ultrasound has been used to track muscle wasting and association with outcomes in critically ill adults but not children. This review aims to summarize methodological considerations of muscle ultrasound, structural findings, and possibilities for its application in the assessment of nutrition and functional outcomes in critically ill children. Medline, Embase, and CINAHL databases were searched up until April 2016. Articles describing skeletal muscle ultrasound in children and critically ill adults were analyzed qualitatively for details on techniques and findings. Thickness and cross-sectional area of various upper and lower body muscles have been studied to quantify muscle mass and detect muscle changes. The quadriceps femoris muscle is one of the most commonly measured muscles due to its relation to mobility and is sensitive to changes over time. However, the margin of error for quadriceps thickness is too wide to reliably detect muscle changes in critically ill children. Muscle size and its correlation with strength and function also have not yet been studied in critically ill children. Echogenicity, used to detect compromised muscle structure in neuromuscular disease, may be another property worth studying in critically ill children. Muscle ultrasound may be useful in detecting muscle wasting in critically ill children but has not been shown to be sufficiently reliable in this population. Further study of the reliability and correlation with functional outcomes and nutrition intake is required before muscle ultrasound is routinely employed in critically ill children.

Effect of Margin Designs on the Marginal Adaptation of Zirconia Copings.

PubMed

Habib, Syed Rashid; Al Ajmi, Mohammed Ginan; Al Dhafyan, Mohammed; Jomah, Abdulrehman; Abualsaud, Haytham; Almashali, Mazen

2017-09-01

The aim of this in vitro study was to investigate the effect of Shoulder versus Chamfer margin design on the marginal adaptation of zirconia (Zr) copings. 40 extracted molar teeth were mounted in resin and prepared for zirconia crowns with two margin preparation designs (20=Shoulder and 20=Chamfer). The copings were manufactured by Cercon® (DeguDent GmbH, Germany) using the CAD/CAM system for each tooth. They were tried on each tooth, cemented, thermocycled, re-embedded in resin and were subsequently cross sectioned centrally into two equal mesial and distal halves. They were examined under electron microscope at 200 X magnification and the measurements were recorded at 5 predetermined points in micrometers (µm). The o verall mean marginal gap for the two groups was found to be 206.98+42.78µm with Shoulder margin design (Marginal Gap=199.50+40.72µm) having better adaptation compared to Chamfer (Marginal Gap=214.46+44.85µm). The independent-samples t-test showed a statistically non-significant difference (p=.113) between the means of marginal gap for Shoulder and Chamfer margin designs and the measurements were recorded at 5 predetermined points for the two groups. The Chamfer margin design appeared to offer the same adaptation results as the Shoulder margin design.

Impact of abutment rotation and angulation on marginal fit: theoretical considerations.

PubMed

Semper, Wiebke; Kraft, Silvan; Mehrhof, Jurgen; Nelson, Katja

2010-01-01

Rotational freedom of various implant positional index designs has been previously calculated. To investigate its clinical relevance, a three-dimensional simulation was performed to demonstrate the influence of rotational displacements of the abutment on the marginal fit of prosthetic superstructures. Idealized abutments with different angulations (0, 5, 10, 15, and 20 degrees) were virtually constructed (SolidWorks Office Premium 2007). Then, rotational displacement was simulated with various degrees of rotational freedom (0.7, 0.95, 1.5, 1.65, and 1.85 degrees). The resulting horizontal displacement of the abutment from the original position was quantified in microns, followed by a simulated pressure-less positioning of superstructures with defined internal gaps (5 µm, 60 µm, and 100 µm). The resulting marginal gap between the abutment and the superstructure was measured vertically with the SolidWorks measurement tool. Rotation resulted in a displacement of the abutment of up to 157 µm at maximum rotation and angulation. Interference of a superstructure with a defined internal gap of 5 µm placed on the abutment resulted in marginal gaps up to 2.33 mm at maximum rotation and angulation; with a 60-µm internal gap, the marginal gaps reached a maximum of 802 µm. Simulation using a superstructure with an internal gap of 100 µm revealed a marginal gap of 162 µm at abutment angulation of 20 degrees and rotation of 1.85 degrees. The marginal gaps increased with the degree of abutment angulation and the extent of rotational freedom. Rotational displacement of the abutment influenced prosthesis misfit. The marginal gaps between the abutment and the superstructure increased with the rotational freedom of the index and the angulation of the abutment.

Statistics of Stacked Strata on Experimental Shelf Margins

NASA Astrophysics Data System (ADS)

Fernandes, A. M.; Straub, K. M.

2015-12-01

Continental margin deposits provide the most complete record on Earth of paleo-landscapes, but these records are complex and difficult to interpret. To a seismic geomorphologist or stratigrapher, mapped surfaces often present a static diachronous record of these landscapes through time. We present data that capture the dynamics of experimental shelf-margin landscapes at high-temporal resolution and define internal hierarchies within stacked channelized and weakly channelized deposits from the shelf to the slope. Motivated by observations from acoustically-imaged continental margins offshore Brunei and in the Gulf of Mexico, we use physical experiments to quantify stratal patterns of sub-aqueous slope channels and lobes that are linked to delta-top channels. The data presented here are from an experiment that was run for 26 hours of experimental run time. Overhead photographs and topographic scans captured flow dynamics and surface aggradation/degradation every ten minutes. Currents rich in sediment built a delta that prograded to the shelf-edge. These currents were designed to plunge at the shoreline and travel as turbidity currents beyond the delta and onto the continental slope. Pseudo-subsidence was imposed by a slight base-level rise that generated accommodation space and promoted the construction of stratigraphy on the delta-top. Compensational stacking is a term that is frequently applied to deposits that tend to fill in topographic lows in channelized and weakly channelized systems. The compensation index, a metric used to quantify the strength of compensation, is used here to characterize deposits at different temporal scales on the experimental landscape. The compensation timescale is the characteristic time at which the accumulated deposits begins to match the shape of basin-wide subsidence rates (uniform for these experiments). We will use the compensation indices along strike transects across the delta, proximal slope and distal slope to evaluate the

CRITICAL LOADS METHODS

EPA Science Inventory

I summarize the results of an interagency project that 1) defines a generic approach to quantifying and reporting critical loads, and 2) exercises that generic approach by examining a data rich system -- the critical loads of sulfur deposition and it's effect on the chronic acidi...

Quantifying the Role of Atmospheric Forcing in Ice Edge Retreat and Advance Including Wind-Wave Coupling

DTIC Science & Technology

2015-09-30

Quantifying the Role of Atmospheric Forcing in Ice Edge Retreat and Advance Including Wind- Wave Coupling Peter S. Guest (NPS Technical Contact) Naval...surface fluxes and ocean waves in coupled models in the Beaufort and Chukchi Seas. 2. Understand the physics of heat and mass transfer from the ocean...to the atmosphere. 3. Improve forecasting of waves on the open ocean and in the marginal ice zone. 2 OBJECTIVES 1. Quantifying the open-ocean

Critical Zone Co-dynamics: Quantifying Interactions between Subsurface, Land Surface, and Vegetation Properties Using UAV and Geophysical Approaches

NASA Astrophysics Data System (ADS)

Dafflon, B.; Leger, E.; Peterson, J.; Falco, N.; Wainwright, H. M.; Wu, Y.; Tran, A. P.; Brodie, E.; Williams, K. H.; Versteeg, R.; Hubbard, S. S.

2017-12-01

Improving understanding and modelling of terrestrial systems requires advances in measuring and quantifying interactions among subsurface, land surface and vegetation processes over relevant spatiotemporal scales. Such advances are important to quantify natural and managed ecosystem behaviors, as well as to predict how watershed systems respond to increasingly frequent hydrological perturbations, such as droughts, floods and early snowmelt. Our study focuses on the joint use of UAV-based multi-spectral aerial imaging, ground-based geophysical tomographic monitoring (incl., electrical and electromagnetic imaging) and point-scale sensing (soil moisture sensors and soil sampling) to quantify interactions between above and below ground compartments of the East River Watershed in the Upper Colorado River Basin. We evaluate linkages between physical properties (incl. soil composition, soil electrical conductivity, soil water content), metrics extracted from digital surface and terrain elevation models (incl., slope, wetness index) and vegetation properties (incl., greenness, plant type) in a 500 x 500 m hillslope-floodplain subsystem of the watershed. Data integration and analysis is supported by numerical approaches that simulate the control of soil and geomorphic characteristic on hydrological processes. Results provide an unprecedented window into critical zone interactions, revealing significant below- and above-ground co-dynamics. Baseline geophysical datasets provide lithological structure along the hillslope, which includes a surface soil horizon, underlain by a saprolite layer and the fractured Mancos shale. Time-lapse geophysical data show very different moisture dynamics in various compartments and locations during the winter and growing season. Integration with aerial imaging reveals a significant linkage between plant growth and the subsurface wetness, soil characteristics and the topographic gradient. The obtained information about the organization and

Red (anthocyanic) leaf margins do not correspond to increased phenolic content in New Zealand Veronica spp.

PubMed Central

Hughes, Nicole M.; Smith, William K.; Gould, Kevin S.

2010-01-01

Background and Aims Red or purple coloration of leaf margins is common in angiosperms, and is found in approx. 25 % of New Zealand Veronica species. However, the functional significance of margin coloration is unknown. We hypothesized that anthocyanins in leaf margins correspond with increased phenolic content in leaf margins and/or the leaf entire, signalling low palatability or leaf quality to edge-feeding insects. Methods Five species of Veronica with red leaf margins, and six species without, were examined in a common garden. Phenolic content in leaf margins and interior lamina regions of juvenile and fully expanded leaves was quantified using the Folin–Ciocalteu assay. Proportions of leaf margins eaten and average lengths of continuous bites were used as a proxy for palatability. Key Results Phenolic content was consistently higher in leaf margins compared with leaf interiors in all species; however, neither leaf margins nor more interior tissues differed significantly in phenolic content with respects to margin colour. Mean phenolic content was inversely correlated with the mean length of continuous bites, suggesting effective deterrence of grazing. However, there was no difference in herbivore consumption of red and green margins, and the plant species with the longest continuous grazing patterns were both red-margined. Conclusions Red margin coloration was not an accurate indicator of total phenolic content in leaf margins or interior lamina tissue in New Zealand Veronica. Red coloration was also ineffective in deterring herbivory on the leaf margin, though studies controlling for variations in leaf structure and biochemistry (e.g. intra-specific studies) are needed before more precise conclusions can be drawn. It is also recommended that future studies focus on the relationship between anthocyanin and specific defence compounds (rather than general phenolic pools), and evaluate possible alternative functions of red margins in leaves (e.g. antioxidants

Terrestrial organic carbon contributions to sediments on the Washington margin

NASA Astrophysics Data System (ADS)

Prahl, F. G.; Ertel, J. R.; Goni, M. A.; Sparrow, M. A.; Eversmeyer, B.

1994-07-01

Elemental and stable carbon isotopic compositions and biomarker concentrations were determined in sediments from the Columbia River basin and the Washington margin in order to evaluate geochemical approaches for quantifying terrestrial organic matter in marine sediments. The biomarkers include: an homologous series of long-chain n-alkanes derived from the surface waxes of higher plants; phenolic and hydroxyalkanoic compounds produced by CuO oxidation of two major vascular plant biopolymers, lignin and cutin. All marine sediments, including samples collected from the most remote sites in Cascadia Basin, showed organic geochemical evidence for the presence of terrestrial organic carbon. Using endmember values for the various biomarkers determined empirically by two independent means, we estimate that the terrestrial contribution to the Washington margin is ~ 60% for shelf sediments, ~ 30% for slope sediments, and decreases further to ≤15% in basin sediments. Results from the same geochemical measurements made with depth in gravity core 6705-7 from Cascadia Seachannel suggest that our approach to assess terrestrial organic carbon contributions to contemporary deposits on the Washington margin can be applied to the study of sediments depositing in this region since the last glacial period.

Quantifying errors without random sampling.

PubMed

Phillips, Carl V; LaPole, Luwanna M

2003-06-12

All quantifications of mortality, morbidity, and other health measures involve numerous sources of error. The routine quantification of random sampling error makes it easy to forget that other sources of error can and should be quantified. When a quantification does not involve sampling, error is almost never quantified and results are often reported in ways that dramatically overstate their precision. We argue that the precision implicit in typical reporting is problematic and sketch methods for quantifying the various sources of error, building up from simple examples that can be solved analytically to more complex cases. There are straightforward ways to partially quantify the uncertainty surrounding a parameter that is not characterized by random sampling, such as limiting reported significant figures. We present simple methods for doing such quantifications, and for incorporating them into calculations. More complicated methods become necessary when multiple sources of uncertainty must be combined. We demonstrate that Monte Carlo simulation, using available software, can estimate the uncertainty resulting from complicated calculations with many sources of uncertainty. We apply the method to the current estimate of the annual incidence of foodborne illness in the United States. Quantifying uncertainty from systematic errors is practical. Reporting this uncertainty would more honestly represent study results, help show the probability that estimated values fall within some critical range, and facilitate better targeting of further research.

Dopamine Reward Prediction Error Responses Reflect Marginal Utility

PubMed Central

Stauffer, William R.; Lak, Armin; Schultz, Wolfram

2014-01-01

Summary Background Optimal choices require an accurate neuronal representation of economic value. In economics, utility functions are mathematical representations of subjective value that can be constructed from choices under risk. Utility usually exhibits a nonlinear relationship to physical reward value that corresponds to risk attitudes and reflects the increasing or decreasing marginal utility obtained with each additional unit of reward. Accordingly, neuronal reward responses coding utility should robustly reflect this nonlinearity. Results In two monkeys, we measured utility as a function of physical reward value from meaningful choices under risk (that adhered to first- and second-order stochastic dominance). The resulting nonlinear utility functions predicted the certainty equivalents for new gambles, indicating that the functions’ shapes were meaningful. The monkeys were risk seeking (convex utility function) for low reward and risk avoiding (concave utility function) with higher amounts. Critically, the dopamine prediction error responses at the time of reward itself reflected the nonlinear utility functions measured at the time of choices. In particular, the reward response magnitude depended on the first derivative of the utility function and thus reflected the marginal utility. Furthermore, dopamine responses recorded outside of the task reflected the marginal utility of unpredicted reward. Accordingly, these responses were sufficient to train reinforcement learning models to predict the behaviorally defined expected utility of gambles. Conclusions These data suggest a neuronal manifestation of marginal utility in dopamine neurons and indicate a common neuronal basis for fundamental explanatory constructs in animal learning theory (prediction error) and economic decision theory (marginal utility). PMID:25283778

Dopamine reward prediction error responses reflect marginal utility.

PubMed

Stauffer, William R; Lak, Armin; Schultz, Wolfram

2014-11-03

Optimal choices require an accurate neuronal representation of economic value. In economics, utility functions are mathematical representations of subjective value that can be constructed from choices under risk. Utility usually exhibits a nonlinear relationship to physical reward value that corresponds to risk attitudes and reflects the increasing or decreasing marginal utility obtained with each additional unit of reward. Accordingly, neuronal reward responses coding utility should robustly reflect this nonlinearity. In two monkeys, we measured utility as a function of physical reward value from meaningful choices under risk (that adhered to first- and second-order stochastic dominance). The resulting nonlinear utility functions predicted the certainty equivalents for new gambles, indicating that the functions' shapes were meaningful. The monkeys were risk seeking (convex utility function) for low reward and risk avoiding (concave utility function) with higher amounts. Critically, the dopamine prediction error responses at the time of reward itself reflected the nonlinear utility functions measured at the time of choices. In particular, the reward response magnitude depended on the first derivative of the utility function and thus reflected the marginal utility. Furthermore, dopamine responses recorded outside of the task reflected the marginal utility of unpredicted reward. Accordingly, these responses were sufficient to train reinforcement learning models to predict the behaviorally defined expected utility of gambles. These data suggest a neuronal manifestation of marginal utility in dopamine neurons and indicate a common neuronal basis for fundamental explanatory constructs in animal learning theory (prediction error) and economic decision theory (marginal utility). Copyright © 2014 The Authors. Published by Elsevier Inc. All rights reserved.

Reconstructing marginality: a new model of cultural diversity in nursing.

PubMed

Southwick, Margaret; Polaschek, Nick

2014-05-01

This article presents a new model of cultural diversity in nursing that critically reconstructs the concept of marginality that underpins other models. Rather than viewing the marginal as "other," marginality is redefined as the space in between the dominant cultural reality and the cultural realities of minority groups located within a society. Members of a minority cultural group who become skilled in the difficult process of negotiating this in-between space open the possibility of transformation within nursing education and practice. This model has been applied in a study of the experience of nursing students of Pacific ethnicity in New Zealand. Subsequently, an undergraduate Pacific nursing program was developed, with greatly increased success rates in registration of Pacific nurses. This model of cultural diversity can also be used to understand nursing practice involving people from minority cultures or other socially excluded categories. Copyright 2014, SLACK Incorporated.

Isostatic and dynamic support of high topography on a North Atlantic passive margin

NASA Astrophysics Data System (ADS)

Pedersen, Vivi K.; Huismans, Ritske S.; Moucha, Robert

2016-07-01

Substantial controversy surrounds the origin of high topography along passive continental margins. Here we focus on the well-documented elevated passive margin in southwestern Scandinavia, and quantify the relative contributions of crustal isostasy and dynamic topography in controlling the present topography. We find that majority of the topography is compensated by the crustal structure, suggesting a topographic age that is in accord with the 400 Myr old Caledonian orogenesis. In addition, we propose that dynamic uplift of ∼300 m has rejuvenated existing topography locally in the coastal region over the last 10 Myr. Such uplift, combined with a general sea level fall, can help explain a variety of observations that have traditionally been interpreted in favor of a peneplain uplift model. We conclude that high topography along the Scandinavian margin cannot represent remnants of a peneplain uplifted within the last 20 Myr. The topography must have been high since the Caledonian orogeny.

Geomorphic response of a continental margin to tectonic and eustatic variations, the Levant margin during the Messinian Salinity Crisis

NASA Astrophysics Data System (ADS)

Ben Moshe, Liran; Ben-Avraham, Zvi; Enzel, Yehouda; Uri, Schattner

2017-04-01

During the Messinian Salinity Crisis (MSC, 5.97±0.01-5.33 Ma) the Mediterranean Levant margin experienced major eustatic and sedimentary cycles as well as tectonic motion along the nearby Dead Sea fault plate boundary. New structures formed along this margin with morphology responding to these changes. Our study focuses on changes in this morphology across the margin. It is based on interpretation of three 3D seismic reflection volumes from offshore Israel. Multi-attribute analysis aided the extraction of key reflectors. Morphologic analysis of these data quantified interacting eustasy, sedimentation, and tectonics. Late Messinian morphologic domains include: (a) continental shelf; (b) 'Delta' anticline, forming a ridge diagonal to the strike of the margin; (c) southward dipping 'Hadera' valley, separating between (a) and (b); (d) 'Delta Gap' - a water gap crossing perpendicular to the anticline axis, exhibiting a sinuous thalweg; (e) continental slope. Drainage across the margin developed in several stages. Remains of turbidite flows crossing the margin down-slope were spotted across the 'Delta' anticline. These flows accumulated with the MSC evaporate sequence and prior to the anticline folding. Rising of the anticline, above the then bathymetry, either blocked or diverted the turbidites. That rising also defined the Hadera valley. In-situ evaporates, covering the valley floor, are, in turn covered by a fan-delta at the distal end of the valley. The fan-delta complex contains eroded evaporites and Lago-Mare fauna. Its top is truncated by dendritic fluvial channels that drained towards the Delta Gap. The Delta Gap was carved through the Delta ridge in a morphological and structural transition zone. We propose that during the first stages of the MSC (5.97±0.01-5.59 ma) destabilization of the continental slope due to oscillating sea level produced gravity currents that flowed through the pre-existing Delta anticline. Subsequent folding of the Delta anticline

Patients' preferences in transplantation from marginal donors: results of a discrete choice experiment.

PubMed

Kamran, Sara; Conti, Filomena; Pomey, Marie-Pascale; Baron, Gabriel; Calmus, Yvon; Vidal-Trecan, Gwenaëlle

2017-06-01

To increase the donor pool, the strategy of transplantation from "marginal" donors was developed though patients' preferences about these donors were insufficiently known. The preferences of patients registered on the waiting list or already transplanted in eight transplant teams covering four main organs (i.e., kidney, liver, heart, and lung) were evaluated using the discrete choice experiment method. In each left during 2 days, patients were interviewed on four scenarios. Of 178 eligible patients, 167 were interviewed; 40% accepted marginal graft in their own situation and 89% at least in one of the scenarios. Imagining urgent situations or rare profiles with difficult access to transplantation, respectively, 86% and 71% accepted these grafts. Most (76%) preferred to be informed about these grafts and 43% preferred to be involved in decision. The emergency [OR = 1.24; 95% CI: (1.06-1.45)] and the hazardousness [OR = 0.88; 95% CI: (0.78-0.99)] of the transplantation were factors independently associated with marginal graft acceptance. Most patients preferred to be informed and to be involved in the decision. Marginal grafts could be more accepted by patients in critical medical situations or perceiving their situation as critical. Physicians' practices in transplantation should be reconsidered taking into account individual preferences. This study was performed in a single country and thus reflects the cultural bias and practice thereof. © 2017 Steunstichting ESOT.

Evaluating marginal likelihood with thermodynamic integration method and comparison with several other numerical methods

DOE PAGES

Liu, Peigui; Elshall, Ahmed S.; Ye, Ming; ...

2016-02-05

Evaluating marginal likelihood is the most critical and computationally expensive task, when conducting Bayesian model averaging to quantify parametric and model uncertainties. The evaluation is commonly done by using Laplace approximations to evaluate semianalytical expressions of the marginal likelihood or by using Monte Carlo (MC) methods to evaluate arithmetic or harmonic mean of a joint likelihood function. This study introduces a new MC method, i.e., thermodynamic integration, which has not been attempted in environmental modeling. Instead of using samples only from prior parameter space (as in arithmetic mean evaluation) or posterior parameter space (as in harmonic mean evaluation), the thermodynamicmore » integration method uses samples generated gradually from the prior to posterior parameter space. This is done through a path sampling that conducts Markov chain Monte Carlo simulation with different power coefficient values applied to the joint likelihood function. The thermodynamic integration method is evaluated using three analytical functions by comparing the method with two variants of the Laplace approximation method and three MC methods, including the nested sampling method that is recently introduced into environmental modeling. The thermodynamic integration method outperforms the other methods in terms of their accuracy, convergence, and consistency. The thermodynamic integration method is also applied to a synthetic case of groundwater modeling with four alternative models. The application shows that model probabilities obtained using the thermodynamic integration method improves predictive performance of Bayesian model averaging. As a result, the thermodynamic integration method is mathematically rigorous, and its MC implementation is computationally general for a wide range of environmental problems.« less

Passive margins getting squeezed in the mantle convection vice

NASA Astrophysics Data System (ADS)

Husson, Laurent; Yamato, Philippe; Becker, Thorsten; Pedoja, Kevin

2013-04-01

Quaternary coastal geomorphology reveals that passive margins underwent wholesale uplift at least during the glacial cycle. In addition, these not-so-passive margins often exhibit long term exhumation and tectonic inversion, which suggest that compression and tectonic shortening could be the mechanism that triggers their overall uplift. We speculate that the compression in the lithosphere gradually increased during the Cenozoic. The many mountain belts at active margins that accompany this event readily witness this increase. Less clear is how that compression increase affects passive margins. In order to address this issue, we design minimalist 2D viscous models to quantify the impact of plate collision on the stress regime. In these models, a sluggish plate is disposed on a less viscous mantle. It is driven by a "mantle conveyor belt" alternatively excited by lateral shear stresses that represent a downwelling on one side, an upwelling on the other side, or both simultaneously. The lateral edges of the plate are either free or fixed, respectively representing the cases of free convergence and collision. In practice, it dramatically changes the upper boundary condition for mantle circulation and subsequently, for the stress field. The flow pattern transiently evolves almost between two end-members, starting from a situation close to a Couette flow to a pattern that looks like a Poiseuille flow with an almost null velocity at the surface (though in the models, the horizontal velocity at the surface is not strictly null, as the lithosphere deforms). In the second case, the lithosphere is highly stressed horizontally and deforms. For an equivalent bulk driving force, compression increases drastically at passive margins if upwellings are active because they push plates towards the collision. Conversely, if only downwellings are activated, compression occurs on one half of the plate and extension on the other half, because only the downwelling is pulling the plate

Improving and Evaluating Nested Sampling Algorithm for Marginal Likelihood Estimation

NASA Astrophysics Data System (ADS)

Ye, M.; Zeng, X.; Wu, J.; Wang, D.; Liu, J.

2016-12-01

With the growing impacts of climate change and human activities on the cycle of water resources, an increasing number of researches focus on the quantification of modeling uncertainty. Bayesian model averaging (BMA) provides a popular framework for quantifying conceptual model and parameter uncertainty. The ensemble prediction is generated by combining each plausible model's prediction, and each model is attached with a model weight which is determined by model's prior weight and marginal likelihood. Thus, the estimation of model's marginal likelihood is crucial for reliable and accurate BMA prediction. Nested sampling estimator (NSE) is a new proposed method for marginal likelihood estimation. The process of NSE is accomplished by searching the parameters' space from low likelihood area to high likelihood area gradually, and this evolution is finished iteratively via local sampling procedure. Thus, the efficiency of NSE is dominated by the strength of local sampling procedure. Currently, Metropolis-Hasting (M-H) algorithm is often used for local sampling. However, M-H is not an efficient sampling algorithm for high-dimensional or complicated parameter space. For improving the efficiency of NSE, it could be ideal to incorporate the robust and efficient sampling algorithm - DREAMzs into the local sampling of NSE. The comparison results demonstrated that the improved NSE could improve the efficiency of marginal likelihood estimation significantly. However, both improved and original NSEs suffer from heavy instability. In addition, the heavy computation cost of huge number of model executions is overcome by using an adaptive sparse grid surrogates.

Quantifying tight-gas sandstone permeability via critical path analysis

USDA-ARS?s Scientific Manuscript database

Rock permeability has been actively investigated over the past several decades by the geosciences community. However, its accurate estimation still presents significant technical challenges, especially in spatially complex rocks. In this letter, we apply critical path analysis (CPA) to estimate perm...

Deep sea sedimentation processes and geomorphology: Northwest Atlantic continental margin

NASA Astrophysics Data System (ADS)

Mosher, David; Campbell, Calvin; Gardner, Jim; Chaytor, Jason; Piper, David; Rebesco, Michele

2017-04-01

Deep-sea sedimentation processes impart a fundamental control on the morphology of the western North Atlantic continental margin from Blake Spur to Hudson Strait. This fact is illustrated by the variable patterns of cross-margin gradients that are based on extensive new multibeam echo-sounder data informed by subbottom profiler and seismic reflection data. Erosion by off-shelf sediment transport in turbidity currents creates gullies, canyons and channels and a steep upper slope. Amalgamation of these conduits produces singular channels and turbidite fan complexes on the lower slope, flattening slope-profile gradients. The effect is an exponentially decaying "graded" slope profile. Comparatively, sediment mass failure produces steeper upper slopes due to head scarp development and a wedging architecture to the lower slope as deposits thin in the downslope direction. This process results in either a "stepped" slope, and/or a significant downslope gradient change where MTDs pinch out. Large drift deposits created by geostrophic currents are developed all along the margin. Blake Ridge, Sackville Spur, and Hamilton Spur are large detached drifts on disparate parts of the margin. They form a linear "above grade" profile along their crests from the shelf to abyssal plain. Deeper portions of the US continental margin are dominated by the Chesapeake Drift and Hatteras Outer Ridge; both plastered elongate mounded drifts. Farther north, particularly on the Grand Banks margin, are plastered and separated drifts. These drifts form "stepped" slope profiles, where they onlap the margin. Trough-mouth fan complexes become more common along the margin with increasing latitude. Sediment deposition and retention, particularly those dominated by glacigenic debris flows, characterize these segments producing an "above grade" slope profile. Understanding these geomorphological consequences of deep sea sedimentation processes is important to extended continental shelf mapping in which

"Centering the Margins": Moving Equity to the Center of Men's Health Research.

PubMed

Griffith, Derek M

2018-05-01

How might the science of men's health progress if research on marginalized or subordinated men is moved from the margins of the literature to the center? This commentary seeks to answer this question, suggesting that if more attention is paid to men of color and other marginalized men, the field will be greatly enriched in its ability to understand determinants of men's health. Reimagining men's health by moving men's health disparities to a primary focus of the field may yield critical new insights that would be essential to moving men's health to the center of health equity research. Focusing on the dual goals of improving the health of marginalized men and examining the determinants of disparities among men and between men and women will yield insights into mechanisms, pathways, and strategies to improve men's health and address health disparities. Current definitions of health disparities limit the nation's ability to dedicate resources to populations that need attention-men of color and other marginalized men-that do not fit these definitions. Moving marginalized men to the center of research in men's health will foster new ways of understanding determinants of men's health that cannot be identified without focusing on populations of men whose health is as influenced by race, ethnicity, and other structures of marginalization as it is by gender and masculinities. Using Black men as a case example, the article illustrates how studying marginalized men can refine the study of men's health and health equity.

Organic carbon burial in a mangrove forest, margin and intertidal mud flat

NASA Astrophysics Data System (ADS)

Sanders, Christian J.; Smoak, Joseph M.; Naidu, A. Sathy; Sanders, Luciana M.; Patchineelam, Sambasiva R.

2010-12-01

The flux of total organic carbon (TOC) to depositional facies (intertidal mud flat, margin and forest) was quantified for a tropical mangrove forest in Brazil. Results indicate that these mangrove margins and intertidal mudflats are sites of large TOC accumulation, almost four times greater than the global averages for mangrove forests. The TOC burial rates were determined from organic carbon content in sediment cores which were dated using 210Pb. Burial rates were calculated to be 1129, 949, and 353 (g m -2 yr -1), for the mud flat, margin and forest, respectively. Sediment accumulation rates (SAR) were estimated to be 7.3, 5.0 and 2.8 mm yr -1. Sediment characterization (δ 13C, δ 15N, TOC/TN and mud fraction) indicated a representative mangrove system with a record of consistent organic matter flux of up to 100 years. Because of substantial burial of organic carbon in mangrove ecosystems, their role in the global carbon budget must be considered. More importantly, as climate change influences temperature and sea level, mangrove ecosystems will respond to specific climatic conditions.

The Role of Margin in Link Design and Optimization

NASA Technical Reports Server (NTRS)

Cheung, K.

2015-01-01

Link analysis is a system engineering process in the design, development, and operation of communication systems and networks. Link models that are mathematical abstractions representing the useful signal power and the undesirable noise and attenuation effects (including weather effects if the signal path transverses through the atmosphere) that are integrated into the link budget calculation that provides the estimates of signal power and noise power at the receiver. Then the link margin is applied which attempts to counteract the fluctuations of the signal and noise power to ensure reliable data delivery from transmitter to receiver. (Link margin is dictated by the link margin policy or requirements.) A simple link budgeting approach assumes link parameters to be deterministic values typically adopted a rule-of-thumb policy of 3 dB link margin. This policy works for most S- and X-band links due to their insensitivity to weather effects. But for higher frequency links like Ka-band, Ku-band, and optical communication links, it is unclear if a 3 dB link margin would guarantee link closure. Statistical link analysis that adopted the 2-sigma or 3-sigma link margin incorporates link uncertainties in the sigma calculation. (The Deep Space Network (DSN) link margin policies are 2-sigma for downlink and 3-sigma for uplink.) The link reliability can therefore be quantified statistically even for higher frequency links. However in the current statistical link analysis approach, link reliability is only expressed as the likelihood of exceeding the signal-to-noise ratio (SNR) threshold that corresponds to a given bit-error-rate (BER) or frame-error-rate (FER) requirement. The method does not provide the true BER or FER estimate of the link with margin, or the required signalto-noise ratio (SNR) that would meet the BER or FER requirement in the statistical sense. In this paper, we perform in-depth analysis on the relationship between BER/FER requirement, operating SNR, and

Methane release from the southern Brazilian margin during the last glacial.

PubMed

Portilho-Ramos, R C; Cruz, A P S; Barbosa, C F; Rathburn, A E; Mulitza, S; Venancio, I M; Schwenk, T; Rühlemann, C; Vidal, L; Chiessi, C M; Silveira, C S

2018-04-13

Seafloor methane release can significantly affect the global carbon cycle and climate. Appreciable quantities of methane are stored in continental margin sediments as shallow gas and hydrate deposits, and changes in pressure, temperature and/or bottom-currents can liberate significant amounts of this greenhouse gas. Understanding the spatial and temporal dynamics of marine methane deposits and their relationships to environmental change are critical for assessing past and future carbon cycle and climate change. Here we present foraminiferal stable carbon isotope and sediment mineralogy records suggesting for the first time that seafloor methane release occurred along the southern Brazilian margin during the last glacial period (40-20 cal ka BP). Our results show that shallow gas deposits on the southern Brazilian margin responded to glacial-interglacial paleoceanographic changes releasing methane due to the synergy of sea level lowstand, warmer bottom waters and vigorous bottom currents during the last glacial period. High sea level during the Holocene resulted in an upslope shift of the Brazil Current, cooling the bottom waters and reducing bottom current strength, reducing methane emissions from the southern Brazilian margin.

Extranodal Marginal Zone B-cell Lymphoma of the Ocular Adnexa.

PubMed

Guffey Johnson, Jean; Terpak, Lauren A; Margo, Curtis E; Setoodeh, Reza

2016-04-01

Low-grade B-cell lymphomas located around the eye present unique challenges in diagnosis and treatment. Extranodal marginal zone B-cell lymphoma is the most common lymphoma of the ocular adnexa (conjunctiva, orbit, lacrimal gland, and eyelid). A systematic search of the relevant literature was performed. Material pertinent to the diagnosis, prognosis, pathogenesis, and treatment of extranodal marginal zone B-cell lymphoma of the ocular adnexa was identified, reviewed, and analyzed, focusing on management strategies for primary localized disease. The primary cause of extranodal marginal zone B-cell lymphoma of the ocular adnexa remains elusive, although an infectious agent is suspected. Radiotherapy is the most common initial treatment for localized disease. Initial treatment with chemotherapy, immunotherapy, and antibiotics has shown promising results, but the number of series is limited and controlled trials do not exist. Although the long-term outcome of localized extranodal marginal zone B-cell lymphoma of the ocular adnexa is good, optimal treatment remains a goal. The variation in rates of local and systemic relapse among treated stage 1E tumors suggests that critical factors affecting outcomes are not fully understood. Radiotherapy is the standard of care; at this time, the evidence is insufficient to recommend chemotherapy, immunotherapy, or antibiotics for initial treatment of extranodal marginal zone B-cell lymphoma localized to the ocular adnexa. Well-controlled comparative studies are needed.

Marginalized zero-inflated negative binomial regression with application to dental caries

PubMed Central

Preisser, John S.; Das, Kalyan; Long, D. Leann; Divaris, Kimon

2015-01-01

The zero-inflated negative binomial regression model (ZINB) is often employed in diverse fields such as dentistry, health care utilization, highway safety, and medicine to examine relationships between exposures of interest and overdispersed count outcomes exhibiting many zeros. The regression coefficients of ZINB have latent class interpretations for a susceptible subpopulation at risk for the disease/condition under study with counts generated from a negative binomial distribution and for a non-susceptible subpopulation that provides only zero counts. The ZINB parameters, however, are not well-suited for estimating overall exposure effects, specifically, in quantifying the effect of an explanatory variable in the overall mixture population. In this paper, a marginalized zero-inflated negative binomial regression (MZINB) model for independent responses is proposed to model the population marginal mean count directly, providing straightforward inference for overall exposure effects based on maximum likelihood estimation. Through simulation studies, the finite sample performance of MZINB is compared to marginalized zero-inflated Poisson, Poisson, and negative binomial regression. The MZINB model is applied in the evaluation of a school-based fluoride mouthrinse program on dental caries in 677 children. PMID:26568034

Interrelation between rifting, faulting, sedimentation, and mantle serpentinization during continental margin formation

NASA Astrophysics Data System (ADS)

Rupke, L.; Schmid, D. W.; Perez-Gussinye, M.; Hartz, E. H.

2013-12-01

We explore the conditions under which mantle serpentinization may take place during continental rifting with 2D thermotectonostratigraphic basin models. The basic concept follows the idea that the entire extending continental crust has to be brittle for crustal scale faulting and mantle serpentinization to occur. The new model tracks the rheological evolution of the continental crust and allows for kinetically controlled mantle serpentinization processes. The isostatic and latent heat effects of the reaction are fully coupled to the structural and thermal solutions. A systematic parameter study shows that a critical stretching factor exists for which complete crustal embrittlement and serpentinization occurs. Sedimentation shifts this critical stretching factor to higher values as both deeper burial and the low thermal conductivity of sediments lead to higher crustal temperatures. Serpentinization reactions are therefore only likely in settings with low sedimentation rates and high stretching factors. In addition, we find that the rate of sediment supply has first order controls on the rheology of the lower crust, which may control the overall margin geometry. We further test these concepts in ideas in a case study for the Norwegian margin. In particular, we evaluate whether the inner lower crustal bodies (LCB) imaged beneath the More and Voring margin could be serpentinized mantle. For this purpose we reconstruct multiple 2D transects through a 3D data set. This reconstruction of the Norwegian margin shows that serpentinization reactions are indeed possible and likely during the Jurassic rift phase. Predicted present-day thicknesses and locations of partially serpentinized mantle rocks fit well to information on LCBs from seismic and gravity data. We conclude that some of the inner LCBs beneath the Norwegian margin may, in fact, be partially serpentinized mantle.

Marginal abatement cost curves for NOx that account for ...

EPA Pesticide Factsheets

A marginal abatement cost curve (MACC) traces out the relationship between the quantity of pollution abated and the marginal cost of abating each additional unit. In the context of air quality management, MACCs typically are developed by sorting end-of-pipe controls by their respective cost effectiveness. Alternative measures, such as renewable electricity, energy efficiency, and fuel switching (RE/EE/FS), are not considered as it is difficult to quantify their abatement potential. In this paper, we demonstrate the use of an energy system model to develop a MACC for nitrogen oxides (NOx) that incorporates both end-of-pipe controls and these alternative measures. We decompose the MACC by sector, and evaluate the cost-effectiveness of RE/EE/FS relative to end-of-pipe controls. RE/EE/FS are shown to produce considerable emission reductions after end-of-pipe controls have been exhausted. Furthermore, some RE/EE/FS are shown to be cost-competitive with end-of-pipe controls. Demonstrate how the MARKAL energy system model can be used to evaluate the potential role of renewable electricity, energy efficiency and fuel switching (RE/EE/FS) in achieving NOx reductions. For this particular analysis, we show that RE/EE/FSs are able to increase the quantity of NOx reductions available for a particular marginal cost (ranging from $5k per ton to $40k per ton) by approximately 50%.

Reconstructing Rodinia by Fitting Neoproterozoic Continental Margins

USGS Publications Warehouse

Stewart, John H.

2009-01-01

Reconstructions of Phanerozoic tectonic plates can be closely constrained by lithologic correlations across conjugate margins by paleontologic information, by correlation of orogenic belts, by paleomagnetic location of continents, and by ocean floor magmatic stripes. In contrast, Proterozoic reconstructions are hindered by the lack of some of these tools or the lack of their precision. To overcome some of these difficulties, this report focuses on a different method of reconstruction, namely the use of the shape of continents to assemble the supercontinent of Rodinia, much like a jigsaw puzzle. Compared to the vast amount of information available for Phanerozoic systems, such a limited approach for Proterozoic rocks, may seem suspect. However, using the assembly of the southern continents (South America, Africa, India, Arabia, Antarctica, and Australia) as an example, a very tight fit of the continents is apparent and illustrates the power of the jigsaw puzzle method. This report focuses on Neoproterozoic rocks, which are shown on two new detailed geologic maps that constitute the backbone of the study. The report also describes the Neoproterozoic, but younger or older rocks are not discussed or not discussed in detail. The Neoproterozoic continents and continental margins are identified based on the distribution of continental-margin sedimentary and magmatic rocks that define the break-up margins of Rodinia. These Neoproterozoic continental exposures, as well as critical Neo- and Meso-Neoproterozoic tectonic features shown on the two new map compilations, are used to reconstruct the Mesoproterozoic supercontinent of Rodinia. This approach differs from the common approach of using fold belts to define structural features deemed important in the Rodinian reconstruction. Fold belts are difficult to date, and many are significantly younger than the time frame considered here (1,200 to 850 Ma). Identifying Neoproterozoic continental margins, which are primarily

WSEAT Shock Testing Margin Assessment Using Energy Spectra Final Report.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sisemore, Carl; Babuska, Vit; Booher, Jason

Several programs at Sandia National Laboratories have adopted energy spectra as a metric to relate the severity of mechanical insults to structural capacity. The purpose being to gain insight into the system's capability, reliability, and to quantify the ultimate margin between the normal operating envelope and the likely system failure point -- a system margin assessment. The fundamental concern with the use of energy metrics was that the applicability domain and implementation details were not completely defined for many problems of interest. The goal of this WSEAT project was to examine that domain of applicability and work out the necessarymore » implementation details. The goal of this project was to provide experimental validation for the energy spectra based methods in the context of margin assessment as they relate to shock environments. The extensive test results concluded that failure predictions using energy methods did not agree with failure predictions using S-N data. As a result, a modification to the energy methods was developed following the form of Basquin's equation to incorporate the power law exponent for fatigue damage. This update to the energy-based framework brings the energy based metrics into agreement with experimental data and historical S-N data.« less

A new technique for quantifying symmetry and opening angles in quartz c-axis pole figures: Implications for interpreting the kinematic and thermal properties of rocks

NASA Astrophysics Data System (ADS)

Hunter, N. J. R.; Weinberg, R. F.; Wilson, C. J. L.; Law, R. D.

2018-07-01

Variations in flow kinematics influence the type of crystallographic preferred orientations (CPOs) in plastically deformed quartz, yet we currently lack a robust means of quantifying the diagnostic symmetries that develop in the c-axis (0001) pole figure. In this contribution, we demonstrate how the symmetry of common c-axis topologies may be quantified by analysing the intensity distribution across a line transect of the pole figure margin. A symmetry value (S) measures the relative difference in intensities between marginal girdle maxima in the pole figure, and thus the degree to which the pole figure defines orthorhombic or monoclinic end member symmetries. This provides a semi-quantitative depiction of whether the rocks underwent coaxial or non-coaxial flow, respectively, and may subsequently be used to quantify other topological properties, such as the opening angle of girdle maxima. The open source Matlab® toolbox MTEX is used to quantify pole figure symmetries in quartzite samples from the Main Central Thrust (NW Himalaya) and the Moine Thrust (NW Scotland).

NRC Continental Margins Workshop

NASA Astrophysics Data System (ADS)

Katsouros, Mary Hope

The Ocean Studies Board of the National Research Council is organizing a workshop, “Continental Margins: Evolution of Passive Continental Margins and Active Marginal Processes,” to stimulate discussion and longterm planning in the scientific community about the evolution of all types of continental margins. We want to coordinate academic, industry, and government agency efforts in this field, and to enhance communication between sea-based and land-based research programs.The continental margins constitute the only available record of the long-term dynamic interaction of oceanic and continental lithosphere. Of great interest are the unique structures and thick sedimentary sequences associated with this interaction. A major focus of the workshop will be to define strategies for exploring and understanding the continental margins in three dimensions and through geologic time. The workshop will be divided into 7 working groups, each concentrating on a major issue in continental margins research. A background document is being prepared summarizing recent research in specific continental margin fields and identifying key scientific and technical issues.

Gigapixel surface imaging of radical prostatectomy specimens for comprehensive detection of cancer-positive surgical margins using structured illumination microscopy

PubMed Central

Wang, Mei; Tulman, David B.; Sholl, Andrew B.; Kimbrell, Hillary Z.; Mandava, Sree H.; Elfer, Katherine N.; Luethy, Samuel; Maddox, Michael M.; Lai, Weil; Lee, Benjamin R.; Brown, J. Quincy

2016-01-01

Achieving cancer-free surgical margins in oncologic surgery is critical to reduce the need for additional adjuvant treatments and minimize tumor recurrence; however, there is a delicate balance between completeness of tumor removal and preservation of adjacent tissues critical for normal post-operative function. We sought to establish the feasibility of video-rate structured illumination microscopy (VR-SIM) of the intact removed tumor surface as a practical and non-destructive alternative to intra-operative frozen section pathology, using prostate cancer as an initial target. We present the first images of the intact human prostate surface obtained with pathologically-relevant contrast and subcellular detail, obtained in 24 radical prostatectomy specimens immediately after excision. We demonstrate that it is feasible to routinely image the full prostate circumference, generating gigapixel panorama images of the surface that are readily interpreted by pathologists. VR-SIM confirmed detection of positive surgical margins in 3 out of 4 prostates with pathology-confirmed adenocarcinoma at the circumferential surgical margin, and furthermore detected extensive residual cancer at the circumferential margin in a case post-operatively classified by histopathology as having negative surgical margins. Our results suggest that the increased surface coverage of VR-SIM could also provide added value for detection and characterization of positive surgical margins over traditional histopathology. PMID:27257084

The substantive theory of surviving on the margin of a profession.

PubMed

Etowa, Josephine B; Sethi, Sarla; Thompson-Isherwood, Roxie

2009-04-01

Using the grounded theory method, a substantive theory of surviving on the margin of a profession emerged as the core variable that explains the patterns of behavior of black nurses in Canada. Data were collected through audiotaped in-depth interviews of 20 black nurses. The three phases of this theory are realizing, surviving, and thriving and the three critical transitions points are the center, the margin, and the proving ground. The phases and transitions points, as well as the conditions that influence variations in the theory are the focus of this paper. These conditions include racism, diversity, and worklife issues such as healthy workplaces.

Quantifying the mode II critical strain energy release rate of borate bioactive glass coatings on Ti6Al4V substrates.

PubMed

Matinmanesh, A; Li, Y; Clarkin, O; Zalzal, P; Schemitsch, E H; Towler, M R; Papini, M

2017-11-01

Bioactive glasses have been used as coatings for biomedical implants because they can be formulated to promote osseointegration, antibacterial behavior, bone formation, and tissue healing through the incorporation and subsequent release of certain ions. However, shear loading on coated implants has been reported to cause the delamination and loosening of such coatings. This work uses a recently developed fracture mechanics testing methodology to quantify the critical strain energy release rate under nearly pure mode II conditions, G IIC , of a series of borate-based glass coating/Ti6Al4V alloy substrate systems. Incorporating increasing amounts of SrCO 3 in the glass composition was found to increase the G IIC almost twofold, from 25.3 to 46.9J/m 2 . The magnitude and distribution of residual stresses in the coating were quantified, and it was found that the residual stresses in all cases distributed uniformly over the cross section of the coating. The crack was driven towards, but not into, the glass/Ti6Al4V substrate interface due to the shear loading. This implied that the interface had a higher fracture toughness than the coating itself. Copyright © 2017 Elsevier Ltd. All rights reserved.

Development and Validation of the Critical Consciousness Scale

ERIC Educational Resources Information Center

Diemer, Matthew A.; Rapa, Luke J.; Park, Catalina J.; Perry, Justin C.

2017-01-01

This article details the development and validation of a measure of critical consciousness, defined as the capacity of oppressed or marginalized people to critically analyze their social and political conditions, endorsement of societal equality, and action to change perceived inequities. In Study 1, an exploratory factor analysis (EFA) was…

Spatial-temporal population dynamics across species range: from centre to margin

Treesearch

Qinfeng Guo; Mark Taper; Michele Schoenberger; J. Brandle

2005-01-01

Understanding the boundaries of species'rangs and the variations in population dynamics from the centre to margin of a species' range is critical. This study simulated spatial-tamporal patterns of birth and death rates and migration across a species' range in different seasons. Our results demonstrated the importance of dispersal and migration in...

Correlation of breast tissue histology and optical signatures to improve margin assessment techniques

NASA Astrophysics Data System (ADS)

Kennedy, Stephanie; Caldwell, Matthew; Bydlon, Torre; Mulvey, Christine; Mueller, Jenna; Wilke, Lee; Barry, William; Ramanujam, Nimmi; Geradts, Joseph

2016-06-01

Optical spectroscopy is sensitive to morphological composition and has potential applications in intraoperative margin assessment. Here, we evaluate ex vivo breast tissue and corresponding quantified hematoxylin & eosin images to correlate optical scattering signatures to tissue composition stratified by patient characteristics. Adipose sites (213) were characterized by their cell area and density. All other benign and malignant sites (181) were quantified using a grid method to determine composition. The relationships between mean reduced scattering coefficient (<μs‧>), and % adipose, % collagen, % glands, adipocyte cell area, and adipocyte density were investigated. These relationships were further stratified by age, menopausal status, body mass index (BMI), and breast density. We identified a positive correlation between <μs‧> and % collagen and a negative correlation between <μs‧> and age and BMI. Increased collagen corresponded to increased <μs‧> variability. In postmenopausal women, <μs‧> was similar regardless of fibroglandular content. Contributions from collagen and glands to <μs‧> were independent and equivalent in benign sites; glands showed a stronger positive correlation than collagen to <μs‧> in malignant sites. Our data suggest that scattering could differentiate highly scattering malignant from benign tissues in postmenopausal women. The relationship between scattering and tissue composition will support improved scattering models and technologies to enhance intraoperative optical margin assessment.

Quantifying Complexity in Quantum Phase Transitions via Mutual Information Complex Networks

NASA Astrophysics Data System (ADS)

Valdez, Marc Andrew; Jaschke, Daniel; Vargas, David L.; Carr, Lincoln D.

2017-12-01

We quantify the emergent complexity of quantum states near quantum critical points on regular 1D lattices, via complex network measures based on quantum mutual information as the adjacency matrix, in direct analogy to quantifying the complexity of electroencephalogram or functional magnetic resonance imaging measurements of the brain. Using matrix product state methods, we show that network density, clustering, disparity, and Pearson's correlation obtain the critical point for both quantum Ising and Bose-Hubbard models to a high degree of accuracy in finite-size scaling for three classes of quantum phase transitions, Z2, mean field superfluid to Mott insulator, and a Berzinskii-Kosterlitz-Thouless crossover.

Tectonostratigraphy of the Passive Continental Margin Offshore Indus Pakistan

NASA Astrophysics Data System (ADS)

Aslam, K.; Khan, M.; Liu, Y.; Farid, A.

2017-12-01

The tectonic evolution and structural complexities are poorly understood in the passive continental margin of the Offshore Indus of Pakistan. In the present study, an attempt has been made to interpret the structural trends and seismic stratigraphic framework in relation to the tectonics of the region. Seismic reflection data revealed tectonically controlled, distinct episodes of normal faulting representing rifting at different ages and transpression in the Late Eocene time. This transpression has resulted in the reactivation of the Pre-Cambrian basement structures. The movement of these basement structures has considerably affected the younger sedimentary succession resulting in push up structures resembling anticlines. The structural growth of the push-up structures was computed. The most remarkable tectonic setting in the region is represented by the normal faulting and by the basement uplift which divides the rifting and transpression stages. Ten mappable seismic sequences have been identified on the seismic records. A Jurassic aged paleo-shelf has also been identified on all regional seismic profiles which is indicative of Indian-African Plates separation during the Jurassic time. Furthermore, the backstripping technique was applied which has been proved to be a powerful technique to quantify subsidence/uplift history of rift-type passive continental margins. The back strip curves suggest that transition from an extensional rifted margin to transpression occurred during Eocene time (50-30 Ma). The backstripping curves show uplift had happened in the area. We infer that the uplift has occurred due to the movement of basement structures by the transpression movements of Arabian and Indian Plates. The present study suggests that the structural styles and stratigraphy of the Offshore Indus Pakistan were significantly affected by the tectonic activities during the separation of Gondwanaland in the Mesozoic and northward movement of the Indian Plate, post

Pollution Emissions, Environmental Policy, and Marginal Abatement Costs.

PubMed

He, Ling-Yun; Ou, Jia-Jia

2017-12-05

Pollution emissions impose serious social negative externalities, especially in terms of public health. To reduce pollution emissions cost-effectively, the marginal abatement costs (MACs) of pollution emissions must be determined. Since the industrial sectors are the essential pillars of China's economic growth, as well as leading energy consumers and sulfur dioxide (SO₂) emitters, estimating MACs of SO₂ emissions at the industrial level can provide valuable information for all abatement efforts. This paper tries to address the critical and essential issue in pollution abatement: How do we determine the MACs of pollution emissions in China? This paper first quantifies the SO₂ emission contribution of different industrial sectors in the Chinese economy by an Input-Output method and then estimates MACs of SO₂ for industrial sectors at the national level, provincial level, and sectoral level by the shadow price theory. Our results show that six sectors (e.g., the Mining and Washing of Coal sector) should be covered in the Chinese pollution emission trading system. We have also found that the lowest SO₂ shadow price is 2000 Yuan/ton at the national level, and that shadow prices should be set differently at the provincial level. Our empirical study has several important policy implications, e.g., the estimated MACs may be used as a pricing benchmark through emission allowance allocation. In this paper, the MACs of industrial sectors are calculated from the national, provincial and sectoral levels; therefore, we provide an efficient framework to track the complex relationship between sectors and provinces.

Pollution Emissions, Environmental Policy, and Marginal Abatement Costs

PubMed Central

He, Ling-Yun; Ou, Jia-Jia

2017-01-01

Pollution emissions impose serious social negative externalities, especially in terms of public health. To reduce pollution emissions cost-effectively, the marginal abatement costs (MACs) of pollution emissions must be determined. Since the industrial sectors are the essential pillars of China’s economic growth, as well as leading energy consumers and sulfur dioxide (SO2) emitters, estimating MACs of SO2 emissions at the industrial level can provide valuable information for all abatement efforts. This paper tries to address the critical and essential issue in pollution abatement: How do we determine the MACs of pollution emissions in China? This paper first quantifies the SO2 emission contribution of different industrial sectors in the Chinese economy by an Input-Output method and then estimates MACs of SO2 for industrial sectors at the national level, provincial level, and sectoral level by the shadow price theory. Our results show that six sectors (e.g., the Mining and Washing of Coal sector) should be covered in the Chinese pollution emission trading system. We have also found that the lowest SO2 shadow price is 2000 Yuan/ton at the national level, and that shadow prices should be set differently at the provincial level. Our empirical study has several important policy implications, e.g., the estimated MACs may be used as a pricing benchmark through emission allowance allocation. In this paper, the MACs of industrial sectors are calculated from the national, provincial and sectoral levels; therefore, we provide an efficient framework to track the complex relationship between sectors and provinces. PMID:29206170

Quantifying the role of trees as Critical Zone architects employing crowbars, wedges and other tools of soil production

NASA Astrophysics Data System (ADS)

Marshall, J. A.; Anderson, R. S.; Dawson, T. E.; Dietrich, W. E.; Sklar, L. S.

2016-12-01

The Critical Zone (CZ) supports diverse functions such as water routing, net primary productivity, carbon storage, and mineral supplies for the geochemical reactor. The detailed architecture of the CZ, and the pace at which it evolves, are strongly influenced by the rate at which bedrock is converted to mobile material (the soil production rate). While trees serve as rebar-like soil stabilizers over short time scales, over longer time scales tree-driven forces can damage, disrupt and detach bedrock, and hence play a key role in soil production. Root growth and tree throw then can both release rock from the underlying bedrock and contribute to the downslope transport of the mobile material. Thus, the physical mechanisms controlling tree-driven soil production may set the pace and style of both the production and transport of soil. However, we know little about how or how often trees damage rock, create fractures, or expand existing fractures in competent bedrock or saprolite. Measurement of the relevant forces at the bedrock-root interface is difficult. Here we present preliminary data from a novel technique that allows us to document both root-growth and wind-induced forces at the rock-root interface at the Boulder Creek and Eel River Critical Zone Observatories. By combining force measurements with wind speed and wind-driven tree sway data, we quantify the magnitude and frequency of tree-driven soil-production mechanisms at two sites with differing climates and lithologies. In addition, we describe physical experiments in which we grow tree roots within pre-instrumented, manufactured fractures to measure the potential for root growth forces to induce crack tip propagation, to induce stress fatigue or to exceed the tensile or compressive strength of weak bedrock. Combined, these field and laboratory measurements provide mechanistic insight into the roles of trees as architects of the Critical Zone.

Access and Retention of Marginalized Populations within Undergraduate Music Education Degree Programs

ERIC Educational Resources Information Center

Fitzpatrick, Kate R.; Henninger, Jacqueline C.; Taylor, Don M.

2014-01-01

The purpose of this collective instrumental case study was to examine the experiences of six undergraduate students from traditionally marginalized populations with regard to their preparation for, admission to, and retention within a music education degree program. Analyzed and reported through the lens of critical theory, data sources included…

Composite marginal quantile regression analysis for longitudinal adolescent body mass index data.

PubMed

Yang, Chi-Chuan; Chen, Yi-Hau; Chang, Hsing-Yi

2017-09-20

Childhood and adolescenthood overweight or obesity, which may be quantified through the body mass index (BMI), is strongly associated with adult obesity and other health problems. Motivated by the child and adolescent behaviors in long-term evolution (CABLE) study, we are interested in individual, family, and school factors associated with marginal quantiles of longitudinal adolescent BMI values. We propose a new method for composite marginal quantile regression analysis for longitudinal outcome data, which performs marginal quantile regressions at multiple quantile levels simultaneously. The proposed method extends the quantile regression coefficient modeling method introduced by Frumento and Bottai (Biometrics 2016; 72:74-84) to longitudinal data accounting suitably for the correlation structure in longitudinal observations. A goodness-of-fit test for the proposed modeling is also developed. Simulation results show that the proposed method can be much more efficient than the analysis without taking correlation into account and the analysis performing separate quantile regressions at different quantile levels. The application to the longitudinal adolescent BMI data from the CABLE study demonstrates the practical utility of our proposal. Copyright © 2017 John Wiley & Sons, Ltd. Copyright © 2017 John Wiley & Sons, Ltd.

Spatial-temporal population dynamics across species range: From centre to margin

USGS Publications Warehouse

Guo, Q.; Taper, M.; Schoenberger, M.; Brandle, J.

2005-01-01

Understanding the boundaries of species' ranges and the variations in population dynamics from the centre to margin of a species' range is critical. This study simulated spatial-temporal patterns of birth and death rates and migration across a species' range in different seasons. Our results demonstrated the importance of dispersal and migration in altering birth and death rates, balancing source and sink habitats, and governing expansion or contraction of species' ranges in changing environments. We also showed that the multiple equilibria of metapopulations across a species' range could be easily broken following climatic changes or physical disturbances either local or regional. Although we refer to our models as describing the population dynamics across whole species' range, they should also apply to small-scale habitats (metapopulations) in which species abundance follows a humped pattern or to any ecosystem or landscape where strong central-marginal (C-M) environmental gradients exist. Conservation of both central and marginal populations would therefore be equally important considerations in making management decisions.

Spatial-temporal population dynamics across species range: from center to margin

USGS Publications Warehouse

Guo, Q.; Taper, M.L.; Schoenberger, M.; Brandl, J.

2005-01-01

Understanding the boundaries of species' ranges and the variations in population dynamics from the centre to margin of a species' range is critical. This study simulated spatial-temporal patterns of birth and death rates and migration across a species' range in different seasons. Our results demonstrated the importance of dispersal and migration in altering birth and death rates, balancing source and sink habitats, and governing expansion or contraction of species' ranges in changing environments. We also showed that the multiple equilibria of metapopulations across a species' range could be easily broken following climatic changes or physical disturbances either or local or regional. Although we refer to our models as describing the population dynamics across whole species' range, they should also apply to small-scale habitats (metapopulations) in which species abundance follows a humped pattern or to any ecosystem or landscape where strong central-marginal (C-M) environmental gradients exist. Conservation of both central and marginal populations would therefore be equally important considerations in making management decisions.

Advances in the Conceptualization and Measurement of Critical Consciousness

ERIC Educational Resources Information Center

Diemer, Matthew A.; McWhirter, Ellen Hawley; Ozer, Emily J.; Rapa, Luke J.

2015-01-01

This article reviews three emergent measures of critical consciousness (CC), which refers to marginalized or oppressed people's critical reflection on oppressive social, economic, or political conditions, the motivation to address perceived injustice, and action taken to counter such injustice in a liberatory manner (Freire in "Education for…

The Southern Cone: A critical element in North American geology

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dalziel, I.W.D.

1993-02-01

The Pacific and Atlantic-Gulf of Mexico continental margins converge towards southern Mexico, delimiting the Southern Cone of North American. The margins are controlled by late Precambrian to early Paleozoic rift systems. The Neoproterozoic rifts along the Pacific margin truncate the 1.3--1.0 Ga Grenville-Llano front and still older structural boundaries within the craton, such as the Snowbird line. The Atlantic margin originated by separation from another continent within the Grenville orogen near the time of the Precambrian-Cambrian boundary. The Gulf of Mexico margin was initiated with rifting at that time, but appears to truncate the Ordovician Taconian orogen in Georgia. Themore » continental margins of the Southern Cone may prove critical in understanding the origin of North America as a discrete continent. A possible continuation of the Grenville-Llano front has now been identified along the Pacific margin of the East Antarctic craton; the opposite side of the Grenville orogen may be present in South America and East Antarctic; a southern continuation of the Taconic Appalachians may have been identified in southern South American and Antarctica (L. Dalla Salda et al., Geology, 1992 a;b: I. Dalziel, Geology, 1991, and GSA Today, 1992; P. Hoffman, Science, 1991; E. Moores, Geology, 1991). Thus the geology of the Southern Cone of North America provides opportunities for critical testing of these globally important hypotheses, notably through geochronometry, isotope geochemistry, stratigraphy, and paleobiogeography. Conversely, East Antarctica, southern Africa, and the proto-Andean margin of South America may offer exciting opportunities to further understanding of pre-Pangea geology across southern North America.« less

Examining marginalized communities and local conservation institutions: the case of Nepal's Annapurna Conservation Area.

PubMed

Dahal, Smriti; Nepal, Sanjay K; Schuett, Michael A

2014-01-01

In developing countries, participatory conservation initiatives have been criticized for many reasons, mainly for excluding marginalized groups which have led to unequal benefits. Using concepts from the literature on participation, conservation, and political ecology, this research explored the participation of marginal groups, i.e., poor, women, lower caste, and landless, in management institutions in Nepal's Annapurna Conservation Area. Field work for this research was conducted through the use of interviews and participant observation during August-October 2010. Results show that although marginal groups were involved in local management institutions, their representation was minimal and had not led to meaningful participation or empowerment to influence the decisions being made in conservation and development programs. Our study findings indicate that the involvement of marginal groups in local initiatives is complex and influenced by several factors. The study concludes that the Annapurna Conservation Area Project needs to re-orient its conservation projects by adopting a more inclusive form of participation and move beyond the quota system.

Examining Marginalized Communities and Local Conservation Institutions: The Case of Nepal's Annapurna Conservation Area

NASA Astrophysics Data System (ADS)

Dahal, Smriti; Nepal, Sanjay K.; Schuett, Michael A.

2014-01-01

In developing countries, participatory conservation initiatives have been criticized for many reasons, mainly for excluding marginalized groups which have led to unequal benefits. Using concepts from the literature on participation, conservation, and political ecology, this research explored the participation of marginal groups, i.e., poor, women, lower caste, and landless, in management institutions in Nepal's Annapurna Conservation Area. Field work for this research was conducted through the use of interviews and participant observation during August-October 2010. Results show that although marginal groups were involved in local management institutions, their representation was minimal and had not led to meaningful participation or empowerment to influence the decisions being made in conservation and development programs. Our study findings indicate that the involvement of marginal groups in local initiatives is complex and influenced by several factors. The study concludes that the Annapurna Conservation Area Project needs to re-orient its conservation projects by adopting a more inclusive form of participation and move beyond the quota system.

The Relationship between an Individual's Margin in Life and Readiness for Change

ERIC Educational Resources Information Center

Madsen, Susan R.; Cameron, John; Miller, Duane; Warren, Emily

2004-01-01

Effectively managing change is one of the most critical challenges organizations today face. Increasing the readiness for change (RFC) of employees may be one of the most important interventions an organization can initiate. This study investigated the relationship of employee RFC and margin in life (MIL). It studied the relationship of various…

Marginal Matter

NASA Astrophysics Data System (ADS)

van Hecke, Martin

2013-03-01

All around us, things are falling apart. The foam on our cappuccinos appears solid, but gentle stirring irreversibly changes its shape. Skin, a biological fiber network, is firm when you pinch it, but soft under light touch. Sand mimics a solid when we walk on the beach but a liquid when we pour it out of our shoes. Crucially, a marginal point separates the rigid or jammed state from the mechanical vacuum (freely flowing) state - at their marginal points, soft materials are neither solid nor liquid. Here I will show how the marginal point gives birth to a third sector of soft matter physics: intrinsically nonlinear mechanics. I will illustrate this with shock waves in weakly compressed granular media, the nonlinear rheology of foams, and the nonlinear mechanics of weakly connected elastic networks.

Quantifying the Incoming Jet Past Heart Valve Prostheses Using Vortex Formation Dynamics

NASA Astrophysics Data System (ADS)

Pierrakos, Olga

2005-11-01

Heart valve (HV) replacement prostheses are associated with hemodynamic compromises compared to their native counterparts. Traditionally, HV performance and hemodynamics have been quantified using effective orifice size and pressure gradients. However, quality and direction of flow are also important aspects of HV function and relate to HV design, implantation technique, and orientation. The flow past any HV is governed by the generation of shear layers followed by the formation and shedding of organized flow structures in the form of vortex rings (VR). For the first time, vortex formation (VF) in the LV is quantified. Vortex energy measurements allow for calculation of the critical formation number (FN), which is the time at which the VR reaches its maximum strength. Inefficiencies in HV function result in critical FN decrease. This study uses the concept of FN to compare mitral HV prostheses in an in-vitro model (a silicone LV model housed in a piston-driven heart simulator) using Time-resolved Digital Particle Image Velocimetry. Two HVs were studied: a porcine HV and bileaflet MHV, which was tested in an anatomic and non-anatomic orientation. The results suggest that HV orientation and design affect the critical FN. We propose that the critical FN, which is contingent on the HV design, orientation, and physical flow characteristics, serve as a parameter to quantify the incoming jet and the efficiency of the HV.

Assessment of the stability of a multimachine power system by the transient energy margin

DOE Office of Scientific and Technical Information (OSTI.GOV)

Stanton, S.E.

1982-01-01

This reasearch develops a tool for the direct assessment of the transient stability of a multimachine electric power system that is subject to a large disturbance. The tool is the Transient Energy Margin. The transient of interest is the first swing (or inertial) transient. The Transient Energy Margin is computed by evaluating an energy function using the relevant unstable equilibrium point and the system states at the instant the disturbance is removed. In evaluating the function, a significant portion of the fault kinetic energy is identified as not contributing to system instability. The resulting energy value is a measure ofmore » the margin-of-safety for the disturbed system. A distinction is proposed between assessing system stability and assessing system security. The Transient Energy Margin is used first to assess the stability of the system. This profile ranks various distrubances to display the strengths and weaknesses of the system. A modified Transient Energy Margin is then proposed as an assessment of security; the transient energy margin profile is repeated to evaluate the system response in terms of the local minimum energy conditions approached by the critical trajectories. Both techniques are applied to a practical, 17 generator test system.« less

Critical Methods in Longitudinal Research with Latino Immigrant Families

ERIC Educational Resources Information Center

Díaz, Yethzèll; Denner, Jill; Ortiz, Eloy

2017-01-01

We have an ethical and a scientific imperative to do research that reflects the views and learning experiences of historically marginalized groups. Most studies that use a critical methodological approach rely on qualitative data. This article describes how a critical approach to recruitment, data collection, and retention can help to ensure that…

The Effect of Water or Wax-based Binders on the Chemical and Morphological Characteristics of the Margin Ceramic-Framework Interface.

PubMed

Güler, Umut; de Queiroz, José Renato Cavalcanti; de Oliveira, Luiz Fernando Cappa; Canay, Senay; Ozcan, Mutlu

2015-09-01

This study evaluated the effect of binder choice in mixing ceramic powder on the chemical and morphological features between the margin ceramic-framework interfaces. Titanium and zirconia frameworks (15 x 5 x 0.5 mm3) were veneered with margin ceramics prepared with two different binders, namely a) water/conventional or b) wax-based. For each zirconia framework material, four different margin ceramics were used: a- Creation Zi (Creation Willi Geller International); b- GC Initial Zr (GC America); Triceram (Dentaurum); and d- IPS emax (voclar Vivadent). For the titanium framework, three different margin ceramics were used: a- Creation Ti (Creation Willi Geller International); b- Triceram (Dentaurum); and c- VITA Titaniumkeramik (Vita Zahnfabrik). The chemical composition of the framework-margin ceramic interface was analyzed using Energy Dispersive X-ray Spectroscopy (EDS) and porosity level was quantified within the margin ceramic using an image program (ImageJ) from four random areas (100 x 100 pixels) on each SEM image. EDS analysis showed the presence of Carbon at the margin ceramic-framework interface in the groups where wax-based binder technique was used with the concentration being the highest for the IPS emax ZirCAD group. While IPS system (IPS ZirCAD and IPS Emax) presented higher porosity concentration using wax binder, in the other groups wax-based binder reduced the porosity of margin ceramic, except for Titanium - Triceram combination.

Geology of continental margins

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

With continued high interest in offshore petroleum exploration, the 1977 AAPG Short Course presents the latest interpretations of new data bearing on the geology and geophysics of continental margins. Seven well-known earth scientists have organized an integrated program covering major topics involved in the development of ocean basins and continental margins with emphasis on the slopes and rises. The discussion of plate tectonics and evolution of continental margins is followed by presentations on the stratigraphy and structure of pull-apart and compressional margins. Prospective petroleum source rocks, their organic content, rate of burial, and distribution on slopes and rises of differentmore » margin types is covered. Prospective reservoir rock patterns are related to depositional processes and to the sedimentary and structural histories for different types of continental margins. Finally, the seismic recognition of depositional facies on slopes and rises for different margin types with varying rates of sediment supply during eustatic sea-level changes are discussed. The course with this syllabus offers an invaluable opportunity for explorationists to refresh their understanding of the geology associated with an important petroleum frontier. In addition, the course sets forth a technical frame of reference for the case-histoy papers to be presented later in the AAPG Research Symposium on the Petroleum Potential of Slopes, Rises, and Plateaus.« less

"Latino Spaces Have Always Been the Most Violent": Afro-Latino Collegians' Perceptions of Colorism and Latino Intragroup Marginalization

ERIC Educational Resources Information Center

Haywood, Jasmine M.

2017-01-01

This study centers on the racialized experiences of Afro-Latino undergraduates at historically White institutions. Of particular interest, I examine how six Afro-Latino collegains experience intragroup marginalization due to colorism. The research design is undergirded by critical race theory and a critical race methodology. Participants'…

Quantifying Ballistic Armor Performance: A Minimally Invasive Approach

NASA Astrophysics Data System (ADS)

Holmes, Gale; Kim, Jaehyun; Blair, William; McDonough, Walter; Snyder, Chad

2006-03-01

Theoretical and non-dimensional analyses suggest a critical link between the performance of ballistic resistant armor and the fundamental mechanical properties of the polymeric materials that comprise them. Therefore, a test methodology that quantifies these properties without compromising an armored vest that is exposed to the industry standard V-50 ballistic performance test is needed. Currently, there is considerable speculation about the impact that competing degradation mechanisms (e.g., mechanical, humidity, ultraviolet) may have on ballistic resistant armor. We report on the use of a new test methodology that quantifies the mechanical properties of ballistic fibers and how each proposed degradation mechanism may impact a vest's ballistic performance.

Quantifying and Improving International Space Station Survivability Following Orbital Debris Penetration

NASA Technical Reports Server (NTRS)

Williamsen, Joel; Evans, Hilary; Bohl, Bill; Evans, Steven; Parker, Nelson (Technical Monitor)

2001-01-01

The increase of the orbital debris environment in low-earth orbit has prompted NASA to develop analytical tools for quantifying and lowering the likelihood of crew loss following orbital debris penetration of the International Space Station (ISS). NASA uses the Manned Spacecraft and Crew Survivability (MSCSurv) computer program to simulate the events that may cause crew loss following orbital debris penetration of ISS manned modules, including: (1) critical cracking (explosive decompression) of the module; (2) critical external equipment penetration (such as hydrazine and high pressure tanks); (3) critical internal system penetration (guidance, control, and other vital components); (4) hazardous payload penetration (furnaces, pressure bottles, and toxic substances); (5) crew injury (from fragments, overpressure, light flash, and temperature rise); (6) hypoxia from loss of cabin pressure; and (7) thrust from module hole causing high angular velocity (occurring only when key Guidance, Navigation, and Control (GN&C) equipment is damaged) and, thus, preventing safe escape vehicle (EV) departure. MSCSurv is also capable of quantifying the 'end effects' of orbital debris penetration, such as the likelihood of crew escape, the probability of each module depressurizing, and late loss of station control. By quantifying these effects (and their associated uncertainties), NASA is able to improve the likelihood of crew survivability following orbital debris penetration due to improved crew operations and internal designs.

Influence of dynamic topography on landscape evolution and passive continental margin stratigraphy

NASA Astrophysics Data System (ADS)

Ding, Xuesong; Salles, Tristan; Flament, Nicolas; Rey, Patrice

2017-04-01

Quantifying the interaction between surface processes and tectonics/deep Earth processes is one important aspect of landscape evolution modelling. Both observations and results from numerical modelling indicate that dynamic topography - a surface expression of time-varying mantle convection - plays a significant role in shaping landscape through geological time. Recent research suggests that dynamic topography also has non-negligible effects on stratigraphic architecture by modifying accommodation space available for sedimentation. In addition, dynamic topography influences the sediment supply to continental margins. We use Badlands to investigate the evolution of a continental-scale landscape in response to transient dynamic uplift or subsidence, and to model the stratigraphic development on passive continental margins in response to sea-level change, thermal subsidence and dynamic topography. We consider a circularly symmetric landscape consisting of a plateau surrounded by a gently sloping continental plain and a continental margin, and a linear wave of dynamic topography. We analyze the evolution of river catchments, of longitudinal river profiles and of the χ values to evaluate the dynamic response of drainage systems to dynamic topography. We calculate the amount of cumulative erosion and deposition, and sediment flux at shoreline position, as a function of precipitation rate and erodibility coefficient. We compute the stratal stacking pattern and Wheeler diagram on vertical cross-sections at the continental margin. Our results indicate that dynamic topography 1) has a considerable influence on drainage reorganization; 2) contributes to shoreline migration and the distribution of depositional packages by modifying the accommodation space; 3) affects sediment supply to the continental margin. Transient dynamic topography contributes to the migration of drainage divides and to the migration of the mainstream in a drainage basin. The dynamic uplift

HyFlux - Part I: Regional Modeling of Methane Flux From Near-Seafloor Gas Hydrate Deposits on Continental Margins

NASA Astrophysics Data System (ADS)

MacDonald, I. R.; Asper, V.; Garcia, O. P.; Kastner, M.; Leifer, I.; Naehr, T.; Solomon, E.; Yvon-Lewis, S.; Zimmer, B.

2008-12-01

HyFlux - Part I: Regional modeling of methane flux from near-seafloor gas hydrate deposits on continental margins MacDonald, I.R., Asper, V., Garcia, O., Kastner, M., Leifer, I., Naehr, T.H., Solomon, E., Yvon-Lewis, S., and Zimmer, B. The Dept. of Energy National Energy Technology Laboratory (DOE/NETL) has recently awarded a project entitled HyFlux: "Remote sensing and sea-truth measurements of methane flux to the atmosphere." The project will address this problem with a combined effort of satellite remote sensing and data collection at proven sites in the Gulf of Mexico where gas hydrate releases gas to the water column. Submarine gas hydrate is a large pool of greenhouse gas that may interact with the atmosphere over geologic time to affect climate cycles. In the near term, the magnitude of methane reaching the atmosphere from gas hydrate on continental margins is poorly known because 1) gas hydrate is exposed to metastable oceanic conditions in shallow, dispersed deposits that are poorly imaged by standard geophysical techniques and 2) the consumption of methane in marine sediments and in the water column is subject to uncertainty. The northern GOM is a prolific hydrocarbon province where rapid migration of oil, gases, and brines from deep subsurface petroleum reservoirs occurs through faults generated by salt tectonics. Focused expulsion of hydrocarbons is manifested at the seafloor by gas vents, gas hydrates, oil seeps, chemosynthetic biological communities, and mud volcanoes. Where hydrocarbon seeps occur in depths below the hydrate stability zone (~500m), rapid flux of gas will feed shallow deposits of gas hydrate that potentially interact with water column temperature changes; oil released from seeps forms sea-surface features that can be detected in remote-sensing images. The regional phase of the project will quantify verifiable sources of methane (and oil) the Gulf of Mexico continental margin and selected margins (e.g. Pakistan Margin, South China Sea

Histologic processing artifacts and inter-pathologist variation in measurement of inked margins of canine mast cell tumors.

PubMed

Kiser, Patti K; Löhr, Christiane V; Meritet, Danielle; Spagnoli, Sean T; Milovancev, Milan; Russell, Duncan S

2018-05-01

Although quantitative assessment of margins is recommended for describing excision of cutaneous malignancies, there is poor understanding of limitations associated with this technique. We described and quantified histologic artifacts in inked margins and determined the association between artifacts and variance in histologic tumor-free margin (HTFM) measurements based on a novel grading scheme applied to 50 sections of normal canine skin and 56 radial margins taken from 15 different canine mast cell tumors (MCTs). Three broad categories of artifact were 1) tissue deformation at inked edges, 2) ink-associated artifacts, and 3) sectioning-associated artifacts. The most common artifacts in MCT margins were ink-associated artifacts, specifically ink absent from an edge (mean prevalence: 50%) and inappropriate ink coloring (mean: 45%). The prevalence of other artifacts in MCT skin was 4-50%. In MCT margins, frequency-adjusted kappa statistics found fair or better inter-rater reliability for 9 of 10 artifacts; intra-rater reliability was moderate or better in 9 of 10 artifacts. Digital HTFM measurements by 5 blinded pathologists had a median standard deviation (SD) of 1.9 mm (interquartile range: 0.8-3.6 mm; range: 0-6.2 mm). Intraclass correlation coefficients demonstrated good inter-pathologist reliability in HTFM measurement (κ = 0.81). Spearman rank correlation coefficients found negligible correlation between artifacts and HTFM SDs ( r ≤ 0.3). These data confirm that although histologic artifacts commonly occur in inked margin specimens, artifacts are not meaningfully associated with variation in HTFM measurements. Investigators can use the grading scheme presented herein to identify artifacts associated with tissue processing.

Large-cell renormalisation and systems of dimensionality larger than the upper marginal dimension

NASA Technical Reports Server (NTRS)

Nakanishi, H.

1984-01-01

A recent argument dismissing the applicability of large-cell renormalization schemes to systems whose dimensionality is larger than the upper marginal dimension is critically discussed. In this connection, new large-cell renormalization results for the random walk for a dimensionality of 3 and 4 are presented which indicate convergence to the correct results.

Indigenous women's voices: marginalization and health.

PubMed

Dodgson, Joan E; Struthers, Roxanne

2005-10-01

Marginalization may affect health care delivery. Ways in which indigenous women experienced marginalization were examined. Data from 57 indigenous women (18 to 65 years) were analyzed for themes. Three themes emerged: historical trauma as lived marginalization, biculturalism experienced as marginalization, and interacting within a complex health care system. Experienced marginalization reflected participants' unique perspective and were congruent with previous research. It is necessary for health care providers to assess the detrimental impact of marginalization on the health status of individuals and/or communities.

Integrating Safety Assessment Methods using the Risk Informed Safety Margins Characterization (RISMC) Approach

DOE Office of Scientific and Technical Information (OSTI.GOV)

Curtis Smith; Diego Mandelli

Safety is central to the design, licensing, operation, and economics of nuclear power plants (NPPs). As the current light water reactor (LWR) NPPs age beyond 60 years, there are possibilities for increased frequency of systems, structures, and components (SSC) degradations or failures that initiate safety significant events, reduce existing accident mitigation capabilities, or create new failure modes. Plant designers commonly “over-design” portions of NPPs and provide robustness in the form of redundant and diverse engineered safety features to ensure that, even in the case of well-beyond design basis scenarios, public health and safety will be protected with a very highmore » degree of assurance. This form of defense-in-depth is a reasoned response to uncertainties and is often referred to generically as “safety margin.” Historically, specific safety margin provisions have been formulated primarily based on engineering judgment backed by a set of conservative engineering calculations. The ability to better characterize and quantify safety margin is important to improved decision making about LWR design, operation, and plant life extension. A systematic approach to characterization of safety margins and the subsequent margin management options represents a vital input to the licensee and regulatory analysis and decision making that will be involved. In addition, as research and development (R&D) in the LWR Sustainability (LWRS) Program and other collaborative efforts yield new data, sensors, and improved scientific understanding of physical processes that govern the aging and degradation of plant SSCs needs and opportunities to better optimize plant safety and performance will become known. To support decision making related to economics, readability, and safety, the RISMC Pathway provides methods and tools that enable mitigation options known as margins management strategies. The purpose of the RISMC Pathway R&D is to support plant decisions for risk

Effect of the Crystallization Process on the Marginal and Internal Gaps of Lithium Disilicate CAD/CAM Crowns.

PubMed

Kim, Jae-Hong; Oh, Seunghan; Uhm, Soo-Hyuk

2016-01-01

The aim of this study is to quantify the effect of the crystallization process on lithium disilicate ceramic crowns fabricated using a computer-aided design/computer-aided manufacturing (CAD/CAM) system and to determine whether the effect of crystallization is clinically acceptable by comparing values of fit before and after the crystallization process. The mandibular right first molar was selected as the abutment for the experiments. Fifteen working models were prepared. Lithium disilicate crowns appropriate for each abutment were prepared using a commercial CAD/CAM system. Gaps in the marginal area and 4 internal areas of each crown were measured twice-before and after crystallization-using the silicone replica technique. The mean values of fit before and after crystallization were analyzed using a paired t-test to examine whether the conversion that occurred during crystallization affected marginal and internal gaps (α = 0.05). Gaps increased in the marginal area and decreased in the internal areas after crystallization. There were statistically significant differences in all of the investigated areas (P < 0.05). None of the values for marginal and internal fit of lithium disilicate CAD/CAM crowns after crystallization exceeded 120 μm, which is the clinically acceptable threshold.

Is plant temporal beta diversity of field margins related to changes in management practices?

NASA Astrophysics Data System (ADS)

Alignier, Audrey; Baudry, Jacques

2016-08-01

Field margins have considerable ecological significance in agriculture-dominated landscapes by supporting biodiversity and associated services. However, agricultural changes during mid-20th century led to their drastic loss with a serious threat for biodiversity. Using time-series data, we aimed to get better insights into processes underlying plant patterns of field margins through time by i) quantifying plant temporal beta diversity components, ii) assessing whether the observed changes in plant communities can be related to changes in management practices applied to field margins. During the springs of 1994, 1998 and 2001, we surveyed plant communities and management practices of the same 116 field margins in three contrasted landscapes. We estimated temporal beta diversity in plant communities and partitioned it into its two dissimilarity resultant components, accounting for replacement of species (i.e. turnover) and for the nested gain or loss of species (i.e. nestedness). We then tested whether the observed changes in plant communities between 1994 and 1998 and, between 1998 and 2001 were related to changes in management practices using linear models. Plant communities of field margins exhibited strong temporal beta diversity dominated by turnover. Temporal turnover in plant communities was partly related to changes in management practices, i.e., a decrease of grazing concomitant to an increase of herbicide spraying. However, relationships were not consistent between all landscape contexts nor time period, suggesting that other unmeasured deterministic or stochastic processes could be driving the observed plant patterns. Taken together, our results suggest that maintaining a wide diversity of field margins with contrasted management contribute to maintaining plant diversity at a landscape scale. They underline the value of investigating plant temporal diversity patterns using time-series data and thus, the need to develop long-term studies making it possible

Marginal and Internal Adaptation of Zirconia Crowns: A Comparative Study of Assessment Methods.

PubMed

Cunali, Rafael Schlögel; Saab, Rafaella Caramori; Correr, Gisele Maria; Cunha, Leonardo Fernandes da; Ornaghi, Bárbara Pick; Ritter, André V; Gonzaga, Carla Castiglia

2017-01-01

Marginal and internal adaptation is critical for the success of indirect restorations. New imaging systems make it possible to evaluate these parameters with precision and non-destructively. This study evaluated the marginal and internal adaptation of zirconia copings fabricated with two different systems using both silicone replica and microcomputed tomography (micro-CT) assessment methods. A metal master model, representing a preparation for an all-ceramic full crown, was digitally scanned and polycrystalline zirconia copings were fabricated with either Ceramill Zi (Amann-Girrbach) or inCoris Zi (Dentslpy-Sirona), n=10. For each coping, marginal and internal gaps were evaluated by silicone replica and micro-CT assessment methods. Four assessment points of each replica cross-section and micro-CT image were evaluated using imaging software: marginal gap (MG), axial wall (AW), axio-occlusal angle (AO) and mid-occlusal wall (MO). Data were statistically analyzed by factorial ANOVA and Tukey test (a=0.05). There was no statistically significant difference between the methods for MG and AW. For AO, there were significant differences between methods for Amann copings, while for Dentsply-Sirona copings similar values were observed. For MO, both methods presented statistically significant differences. A positive correlation was observed determined by the two assessment methods for MG values. In conclusion, the assessment method influenced the evaluation of marginal and internal adaptation of zirconia copings. Micro-CT showed lower marginal and internal gap values when compared to the silicone replica technique, although the difference was not always statistically significant. Marginal gap and axial wall assessment points showed the lower gap values, regardless of ceramic system and assessment method used.

Quantifying variable rainfall intensity events on runoff and sediment losses

USDA-ARS?s Scientific Manuscript database

Coastal Plain soils in Georgia are susceptible to runoff, sediment, and chemical losses from short duration-high intensity, runoff producing storms at critical times during the growing season. We quantified runoff and sediment losses from a Tifton loamy sand managed under conventional- (CT) and stri...

Informing practice regarding marginalization: the application of the Koci Marginality Index.

PubMed

Koci, Anne Floyd; McFarlane, Judith; Nava, Angeles; Gilroy, Heidi; Maddoux, John

2012-12-01

The 49th World Health Assembly of the World Health Organization (WHO) declared violence as the leading worldwide public health problem with a focus on the increase in the incidence of injuries to women. Violence against women is an international epidemic with specific instruments required to measure the impact on women's functioning. This article describes the application of the Koci Marginality Index (KMI), a 5-item scale to measure marginality, to the baseline data of a seven-year prospective study of 300 abused women: 150 first time users of a shelter and 150 first time applicants for a protection order from the justice system. Validity and reliability of the Koci Marginality Index and its usefulness for best clinical practice and for policy decisions for abused women's health are discussed. The 49th World Health Assembly of the World Health Organization (WHO) declared violence as the leading worldwide public health problem and focused on the increase in the incidence of injuries to women (Krug et al., 2002 ). Violence against women in the form of intimate partner violence (IPV) is costly in terms of dollars and health. In the United States in 2003, estimated costs of IPV approached $8.3 billion (Centers for Disease Control and Prevention [CDC], 2011). Outcomes related to severity of IPV vary but in 2003 victims suffering severe IPV lost nearly 8 million days of paid work, and greater than 5 million days of household productivity annually (CDC, 2011). Besides the evident financial cost of IPV, research confirms that exposure to IPV impacts a woman's health immediately and in the long-term (Breiding, Black, & Ryan, 2008 ; Campbell, 2002 ; CDC, 2011). Such sequela adversely affect the health of women and may increase their marginalization, a concept akin to isolation that may further increase negative effects on health outcomes. Immigrant women are at high risk for IPV (Erez, 2002 ) and those without documentation are at higher risk for marginalization (Montalvo

Marginalization: A Revisitation With Integration of Scholarship on Globalization, Intersectionality, Privilege, Microaggressions, and Implicit Biases.

PubMed

Hall, Joanne M; Carlson, Kelly

2016-01-01

In 1994, the concept of marginalization was explored in an article in Advances in Nursing Science. This is a revisitation of the concept incorporating new scholarship. This update is founded on feminism, postcolonialism, critical race theory, and discourse deconstruction, all viewpoints that have been explicated in nursing. The purpose of this analysis is to look at new scholarship and concepts useful to applying marginalization in nursing knowledge development from the standpoint of Bourdieu's macro, meso, and micro levels. New scholarship includes globalization, intersectionality, privilege, microaggressions, and implicit bias. Implications for decreasing health disparities through this new scholarship are discussed.

Sensitivity of postplanning target and OAR coverage estimates to dosimetric margin distribution sampling parameters.

PubMed

Xu, Huijun; Gordon, J James; Siebers, Jeffrey V

2011-02-01

A dosimetric margin (DM) is the margin in a specified direction between a structure and a specified isodose surface, corresponding to a prescription or tolerance dose. The dosimetric margin distribution (DMD) is the distribution of DMs over all directions. Given a geometric uncertainty model, representing inter- or intrafraction setup uncertainties or internal organ motion, the DMD can be used to calculate coverage Q, which is the probability that a realized target or organ-at-risk (OAR) dose metric D, exceeds the corresponding prescription or tolerance dose. Postplanning coverage evaluation quantifies the percentage of uncertainties for which target and OAR structures meet their intended dose constraints. The goal of the present work is to evaluate coverage probabilities for 28 prostate treatment plans to determine DMD sampling parameters that ensure adequate accuracy for postplanning coverage estimates. Normally distributed interfraction setup uncertainties were applied to 28 plans for localized prostate cancer, with prescribed dose of 79.2 Gy and 10 mm clinical target volume to planning target volume (CTV-to-PTV) margins. Using angular or isotropic sampling techniques, dosimetric margins were determined for the CTV, bladder and rectum, assuming shift invariance of the dose distribution. For angular sampling, DMDs were sampled at fixed angular intervals w (e.g., w = 1 degree, 2 degrees, 5 degrees, 10 degrees, 20 degrees). Isotropic samples were uniformly distributed on the unit sphere resulting in variable angular increments, but were calculated for the same number of sampling directions as angular DMDs, and accordingly characterized by the effective angular increment omega eff. In each direction, the DM was calculated by moving the structure in radial steps of size delta (=0.1, 0.2, 0.5, 1 mm) until the specified isodose was crossed. Coverage estimation accuracy deltaQ was quantified as a function of the sampling parameters omega or omega eff and delta. The

Future coral reef habitat marginality: Temporal and spatial effects of climate change in the Pacific basin

USGS Publications Warehouse

Guinotte, J.M.; Buddemeier, R.W.; Kleypas, J.A.

2003-01-01

Marginal reef habitats are regarded as regions where coral reefs and coral communities reflect the effects of steady-state or long-term average environmental limitations. We used classifications based on this concept with predicted time-variant conditions of future climate to develop a scenario for the evolution of future marginality. Model results based on a conservative scenario of atmospheric CO2 increase were used to examine changes in sea surface temperature and aragonite saturation state over the Pacific Ocean basin until 2069. Results of the projections indicated that essentially all reef locations are likely to become marginal with respect to aragonite saturation state. Significant areas, including some with the highest biodiversity, are expected to experience high-temperature regimes that may be marginal, and additional areas will enter the borderline high temperature range that have experienced significant ENSO-related bleaching in the recent past. The positive effects of warming in areas that are presently marginal in terms of low temperature were limited. Conditions of the late 21st century do not lie outside the ranges in which present-day marginal reef systems occur. Adaptive and acclimative capabilities of organisms and communities will be critical in determining the future of coral reef ecosystems.

Critical Social Class Theory for Music Education

ERIC Educational Resources Information Center

Bates, Vincent C.

2017-01-01

This work of critical social theory explores how formal music education in modern capitalist societies mirrors the hierarchical, means-ends, one-dimensional structures of capitalism. So, rather than consistently or reliably empowering and emancipating children musically, school music can tend to marginalize, exploit, repress, and alienate. The…

Quantitative Segmentation of Fluorescence Microscopy Images of Heterogeneous Tissue: Application to the Detection of Residual Disease in Tumor Margins.

PubMed

Mueller, Jenna L; Harmany, Zachary T; Mito, Jeffrey K; Kennedy, Stephanie A; Kim, Yongbaek; Dodd, Leslie; Geradts, Joseph; Kirsch, David G; Willett, Rebecca M; Brown, J Quincy; Ramanujam, Nimmi

2013-01-01

To develop a robust tool for quantitative in situ pathology that allows visualization of heterogeneous tissue morphology and segmentation and quantification of image features. TISSUE EXCISED FROM A GENETICALLY ENGINEERED MOUSE MODEL OF SARCOMA WAS IMAGED USING A SUBCELLULAR RESOLUTION MICROENDOSCOPE AFTER TOPICAL APPLICATION OF A FLUORESCENT ANATOMICAL CONTRAST AGENT: acriflavine. An algorithm based on sparse component analysis (SCA) and the circle transform (CT) was developed for image segmentation and quantification of distinct tissue types. The accuracy of our approach was quantified through simulations of tumor and muscle images. Specifically, tumor, muscle, and tumor+muscle tissue images were simulated because these tissue types were most commonly observed in sarcoma margins. Simulations were based on tissue characteristics observed in pathology slides. The potential clinical utility of our approach was evaluated by imaging excised margins and the tumor bed in a cohort of mice after surgical resection of sarcoma. Simulation experiments revealed that SCA+CT achieved the lowest errors for larger nuclear sizes and for higher contrast ratios (nuclei intensity/background intensity). For imaging of tumor margins, SCA+CT effectively isolated nuclei from tumor, muscle, adipose, and tumor+muscle tissue types. Differences in density were correctly identified with SCA+CT in a cohort of ex vivo and in vivo images, thus illustrating the diagnostic potential of our approach. The combination of a subcellular-resolution microendoscope, acriflavine staining, and SCA+CT can be used to accurately isolate nuclei and quantify their density in anatomical images of heterogeneous tissue.

Marginal Lands: Concept, Assessment and Management

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kang, Shujiang; Post, Wilfred M; West, Tristram O.

2013-01-01

Marginal lands have received wide attention for their potential to improve food security and support bioenergy production. However, environmental, ecosystem service, and sustainability concerns have been widely raised over the use of marginal land. Knowledge of the extent, location, and quality of marginal lands as well as their assessment and management are limited and diverse. This paper provides a review of the historical development of marginal concept, its application and assessment. Limitations and priority research needs of marginal land assessment and management were discussed.

Critical Consciousness: A Key to Student Achievement

ERIC Educational Resources Information Center

El-Amin, Aaliyah; Seider, Scott; Graves, Daren; Tamerat, Jalene; Clark, Shelby; Soutter, Madora; Johannsen, Jamie; Malhotra, Saira

2017-01-01

Research has suggested that critical consciousness--the ability to recognize and analyze systems of inequality and the commitment to take action against these systems--can be a gateway to academic motivation and achievement for marginalized students. To explore this approach, the authors studied five urban schools that include critical…

Effect of the Crystallization Process on the Marginal and Internal Gaps of Lithium Disilicate CAD/CAM Crowns

PubMed Central

Kim, Jae-Hong; Oh, Seunghan; Uhm, Soo-Hyuk

2016-01-01

The aim of this study is to quantify the effect of the crystallization process on lithium disilicate ceramic crowns fabricated using a computer-aided design/computer-aided manufacturing (CAD/CAM) system and to determine whether the effect of crystallization is clinically acceptable by comparing values of fit before and after the crystallization process. The mandibular right first molar was selected as the abutment for the experiments. Fifteen working models were prepared. Lithium disilicate crowns appropriate for each abutment were prepared using a commercial CAD/CAM system. Gaps in the marginal area and 4 internal areas of each crown were measured twice—before and after crystallization—using the silicone replica technique. The mean values of fit before and after crystallization were analyzed using a paired t-test to examine whether the conversion that occurred during crystallization affected marginal and internal gaps (α = 0.05). Gaps increased in the marginal area and decreased in the internal areas after crystallization. There were statistically significant differences in all of the investigated areas (P < 0.05). None of the values for marginal and internal fit of lithium disilicate CAD/CAM crowns after crystallization exceeded 120 μm, which is the clinically acceptable threshold. PMID:27123453

Structure and evolution of the NE Atlantic conjugate margins off Norway and Greenland (Invited)

NASA Astrophysics Data System (ADS)

Faleide, J.; Planke, S.; Theissen-Krah, S.; Abdelmalak, M.; Zastrozhnov, D.; Tsikalas, F.; Breivik, A. J.; Torsvik, T. H.; Gaina, C.; Schmid, D. W.; Myklebust, R.; Mjelde, R.

2013-12-01

The continental margins off Norway and NE Greenland evolved in response to the Cenozoic opening of the NE Atlantic. The margins exhibit a distinct along-margin segmentation reflecting structural inheritance extending back to a complex pre-breakup geological history. The sedimentary basins at the conjugate margins developed as a result of multiple phases of post-Caledonian rifting from Late Paleozoic time to final NE Atlantic breakup at the Paleocene-Eocene transition. The >200 million years of repeated extension caused comprehensive crustal thinning and formation of deep sedimentary basins. The main rift phases span the following time intervals: Late Permian, late Middle Jurassic-earliest Cretaceous, Early-mid Cretaceous and Late Cretaceous-Paleocene. The late Mesozoic-early Cenozoic rifting was related to the northward propagation of North Atlantic sea floor spreading, but also linked to important tectonic events in the Arctic. The pre-drift extension is quantified based on observed geometries of crustal thinning and stretching factors derived from tectonic modeling. The total (cumulative) pre-drift extension amounts to in the order of 300 km which correlates well with estimates from plate reconstructions based on paleomagnetic data. Final lithospheric breakup at the Paleocene-Eocene transition culminated in a 3-6 m.y. period of massive magmatic activity during breakup and onset of early sea-floor spreading, forming a part of the North Atlantic Volcanic Province. At the outer parts of the conjugate margins, the lavas form characteristic seaward dipping reflector sequences and lava deltas that drilling has demonstrated to be subaerially and/or neritically erupted basalts. The continent-ocean transition is usually well defined as a rapid increase of P-wave velocities at mid- to lower-crustal levels. Maximum igneous crustal thickness of about 18 km is found across the outer Vøring Plateau on the Norwegian Margin, and lower-crustal P-wave velocities of up to 7.3 km

Approaching Praxis: YPAR as Critical Pedagogical Process in a College Access Program

ERIC Educational Resources Information Center

Scott, Mary Alice; Pyne, Kimberly B.; Means, Darris R.

2015-01-01

To address the persistent failure of schooling to support underserved students, youth participatory action research (YPAR) has emerged as an alternative and critical paradigm for educational practice. YPAR re-centers authority on marginalized voices and understands research as a tool for social change. Grounded in critical pedagogy, such projects…

Challenges in process marginality for advanced technology nodes and tackling its contributors

NASA Astrophysics Data System (ADS)

Narayana Samy, Aravind; Schiwon, Roberto; Seltmann, Rolf; Kahlenberg, Frank; Katakamsetty, Ushasree

2013-10-01

Process margin is getting critical in the present node shrinkage scenario due to the physical limits reached (Rayleigh's criterion) using ArF lithography tools. K1 is used to its best for better resolution and to enhance the process margin (28nm metal patterning k1=0.31). In this paper, we would like to give an overview of various contributors in the advanced technology nodes which limit the process margins and how the challenges have been tackled in a modern foundry model. Advanced OPC algorithms are used to make the design content at the mask optimum for patterning. However, as we work at the physical limit, critical features (Hot-spots) are very susceptible to litho process variations. Furthermore, etch can have a significant impact as well. Pattern that still looks healthy at litho can fail due to etch interactions. This makes the traditional 2D contour output from ORC tools not able to predict accurately all defects and hence not able to fully correct it in the early mask tapeout phase. The above makes a huge difference in the fast ramp-up and high yield in a competitive foundry market. We will explain in this paper how the early introduction of 3D resist model based simulation of resist profiles (resist top-loss, bottom bridging, top-rounding, etc.,) helped in our prediction and correction of hot-spots in the early 28nm process development phase. The paper also discusses about the other overall process window reduction contributors due to mask 3D effects, wafer topography (focus shifts/variations) and how this has been addressed with different simulation efforts in a fast and timely manner.

Bioactive glass fillers reduce bacterial penetration into marginal gaps for composite restorations

PubMed Central

Khvostenko, D.; Hilton, T. J.; Ferracane, J. L.; Mitchell, J. C.; Kruzic, J. J.

2015-01-01

Objectives Bioactive glass (BAG) is known to possess antimicrobial and remineralizing properties; however, the use of BAG as a filler for resin based composite restorations to slow recurrent caries has not been studied. Accordingly, the objective of this study was to investigate the effect of 15 wt% BAG additions to a resin composite on bacterial biofilms penetrating into marginal gaps of simulated tooth fillings in vitro during cyclic mechanical loading. Methods Human molars were machined into approximately 3 mm thick disks of dentin and 1.5–2 mm deep composite restorations were placed. A narrow 15–20 micrometer wide dentin-composite gap was allowed to form along half of the margin by not applying dental adhesive to that region. Two different 72 wt% filled composites were used, one with 15 wt% BAG filler (15BAG) and the balance silanated strontium glass and one filled with OX-50 and silanated strontium glass without BAG (0BAG – control). Samples of both groups had Streptococcus mutans biofilms grown on the surface and were tested inside a bioreactor for two weeks while subjected to periods of cyclic mechanical loading. After post-test biofilm viability was confirmed, each specimen was fixed in glutaraldehyde, gram positive stained, mounted in resin and cross-sectioned to reveal the gap profile. Depth of biofilm penetration for 0BAG and 15BAG was quantified as the fraction of gap depth. The data were compared using a Student’s t-test. Results The average depth of bacterial penetration into the marginal gap for the 15BAG samples was significantly smaller (~61%) in comparison to 0BAG, where 100% penetration was observed for all samples with the biofilm penetrating underneath of the restoration in some cases. Significance BAG containing resin dental composites reduce biofilm penetration into marginal gaps of simulated tooth restorations. This suggests BAG containing composites may have the potential to slow the development and propagation of secondary tooth

Decoding the Margins: What Can the Fractal Geometry of Basaltic Flow Margins Tell Us?

NASA Astrophysics Data System (ADS)

Schaefer, E. I.; Hamilton, C.; Neish, C.; Beard, S. P.; Bramson, A. M.; Sori, M.; Rader, E. L.

2016-12-01

Studying lava flows on other planetary bodies is essential to characterizing eruption styles and constraining the bodies' thermal evolution. Although planetary basaltic flows are common, many key features are not resolvable in orbital imagery. We are thus developing a technique to characterize basaltic flow type, sub-meter roughness, and sediment mantling from these data. We will present the results from upcoming fieldwork at Craters of the Moon National Monument and Preserve with FINESSE (August) and at Hawai'i Volcanoes National Park (September). We build on earlier work that showed that basaltic flow margins are approximately fractal [Bruno et al., 1992; Gaonac'h et al., 1992] and that their fractal dimensions (D) have distinct `a`ā and pāhoehoe ranges under simple conditions [Bruno et al., 1994]. Using a differential GPS rover, we have recently shown that the margin of Iceland's 2014 Holuhraun flow exhibits near-perfect (R2=0.9998) fractality for ≥24 km across dm to km scales [Schaefer et al., 2016]. This finding suggests that a fractal-based technique has significant potential to characterize flows at sub-resolution scales. We are simultaneously seeking to understand how margin fractality can be modified. A preliminary result for an `a'ā flow in Hawaii's Ka'ū Desert suggests that although aeolian mantling obscures the original flow margin, the apparent margin (i.e., sediment-lava interface) remains fractal [Schaefer et al., 2015]. Further, the apparent margin's D is likely significantly modified from that of the original margin. Other factors that we are exploring include erosion, transitional flow types, and topographic confinement. We will also rigorously test the intriguing possibility that margin D correlates with the sub-meter Hurst exponent H of the flow surface, a common metric of roughness scaling [e.g., Shepard et al., 2001]. This hypothesis is based on geometric arguments [Turcotte, 1997] and is qualitatively consistent with all results so far.

Evaluation of the setup margins for cone beam computed tomography–guided cranial radiosurgery: A phantom study

DOE Office of Scientific and Technical Information (OSTI.GOV)

Calvo Ortega, Juan Francisco, E-mail: jfcdrr@yahoo.es; Wunderink, Wouter; Delgado, David

The aim of this study is to evaluate the setup margins from the clinical target volume (CTV) to planning target volume (PTV) for cranial stereotactic radiosurgery (SRS) treatments guided by cone beam computed tomography (CBCT). We designed an end-to-end (E2E) test using a skull phantom with an embedded 6mm tungsten ball (target). A noncoplanar plan was computed (E2E plan) to irradiate the target. The CBCT-guided positioning of the skull phantom on the linac was performed. Megavoltage portal images were acquired after 15 independent deliveries of the E2E plan. The displacement 2-dimensional (2D) vector between the centers of the square fieldmore » and the ball target on each portal image was used to quantify the isocenter accuracy. Geometrical margins on each patient's direction (left-right or LR, anterior-posterior or AP, superior-inferior or SI) were calculated. Dosimetric validation of the margins was performed in 5 real SRS cases: 3-dimesional (3D) isocenter deviations were mimicked, and changes in CTV dose coverage and organs-at-risk (OARs) dosage were analyzed. The CTV-PTV margins of 1.1 mm in LR direction, and 0.7 mm in AP and SI directions were derived from the E2E tests. The dosimetric analysis revealed that a 1-mm uniform margin was sufficient to ensure the CTV dose coverage, without compromising the OAR dose tolerances. The effect of isocenter uncertainty has been estimated to be 1 mm in our CBCT-guided SRS approach.« less

Quantification of the effects of eustasy, subsidence, and sediment supply on Miocene sequences, mid-Atlantic margin of the United States

USGS Publications Warehouse

Browning, J.V.; Miller, K.G.; McLaughlin, P.P.; Kominz, M.A.; Sugarman, P.J.; Monteverde, D.; Feigenson, M.D.; Hernandez, J.C.

2006-01-01

We use backstripping to quantify the roles of variations in global sea level (eustasy), subsidence, and sediment supply on the development of the Miocene stratigraphic record of the mid-Atlantic continental margin of the United States (New Jersey, Delaware, and Maryland). Eustasy is a primary influence on sequence patterns, determining the global template of sequences (i.e., times when sequences can be preserved) and explaining similarities in Miocene sequence architecture on margins throughout the world. Sequences can be correlated throughout the mid-Atlantic region with Sr-isotopic chronology (??0.6 m.y. to ??1.2 m.y.). Eight Miocene sequences correlate regionally and can be correlated to global ??18O increases, indicating glacioeustatic control. This margin is dominated by passive subsidence with little evidence for active tectonic overprints, except possibly in Maryland during the early Miocene. However, early Miocene sequences in New Jersey and Delaware display a patchwork distribution that is attributable to minor (tens of meters) intervals of excess subsidence. Backstripping quantifies that excess subsidence began in Delaware at ca. 21 Ma and continued until 12 Ma, with maximum rates from ca. 21-16 Ma. We attribute this enhanced subsidence to local flexural response to the progradation of thick sequences offshore and adjacent to this area. Removing this excess subsidence in Delaware yields a record that is remarkably similar to New Jersey eustatic estimates. We conclude that sea-level rise and fall is a first-order control on accommodation providing similar timing on all margins to the sequence record. Tectonic changes due to movement of the crust can overprint the record, resulting in large gaps in the stratigraphic record. Smaller differences in sequences can be attributed to local flexural loading effects, particularly in regions experiencing large-scale progradation. ?? 2006 Geological Society of America.

Quantifying suitable habitat of the threatened western prairie fringed orchid

Treesearch

Paige M. Wolken; Carolyn Hull Sieg; Stephen E. Williams

2001-01-01

Land managers need accurate and quick techniques to identify suitable habitat of species of interest. For species protected by federal or state laws, identification of suitable habitat is critical for developing a conservation strategy that includes reestablishing populations and altering management to address this need. In this research, we quantified vegetative and...

Children's interpretations of general quantifiers, specific quantifiers, and generics

PubMed Central

Gelman, Susan A.; Leslie, Sarah-Jane; Was, Alexandra M.; Koch, Christina M.

2014-01-01

Recently, several scholars have hypothesized that generics are a default mode of generalization, and thus that young children may at first treat quantifiers as if they were generic in meaning. To address this issue, the present experiment provides the first in-depth, controlled examination of the interpretation of generics compared to both general quantifiers ("all Xs", "some Xs") and specific quantifiers ("all of these Xs", "some of these Xs"). We provided children (3 and 5 years) and adults with explicit frequency information regarding properties of novel categories, to chart when "some", "all", and generics are deemed appropriate. The data reveal three main findings. First, even 3-year-olds distinguish generics from quantifiers. Second, when children make errors, they tend to be in the direction of treating quantifiers like generics. Third, children were more accurate when interpreting specific versus general quantifiers. We interpret these data as providing evidence for the position that generics are a default mode of generalization, especially when reasoning about kinds. PMID:25893205

Sediment budget on African passive margins: a record of margin bulges and far field very long wavelength deformations

NASA Astrophysics Data System (ADS)

Guillocheau, Francois; Robin, Cécile; Baby, Guillaume; Simon, Brendan; Rouby, Delphine; Loparev, Artiom

2017-04-01

The post-rift siliciclastic sediment budget of passive margins is a function of (1) the deformation (uplift) of the upstream catchment, of (2) the climate (precipitation) regime and of (3) the oceanic circulation (mainly since Miocene times). The main questions in source to sink studies are (1) to quantify the relative importance of the erosion due to uplifts or to precipitation changes and (2) to characterize the source of the sediments. A source to sink study was carried out in Western, Central and Austral Africa, characterized by anorogenic relief (plains and plateaus) that record long (several 100 km) to very long (several 1000 km) wavelength deformations respectively of lithospheric and mantle origin. The sink measurement was based on seismic lines and wells (industrial - IODP) using the VolumeEstimator software including the calculation of the uncertainties (Guillocheau et al., 2013, Basin Research). The source study was performed using dated stepped planation surfaces (etchplains and pediplains), mappable at catchments-scale (Guillocheau et al., in press, Gondwana Research). Results: (1) Deformation (uplift) is the dominant control of the sediment budget. Climate (precipitation) changes only enhance or inhibit a deformation-controlled flux. (2) The sources of siliciclastic sediments are either closed marginal bulges or far field domes due to mantle dynamics with river by-passing over long-lasting polygenic surfaces located between the bulges and domes. Two main periods of African-scale deformations (contemporaneous with an increase of the sedimentary flux) are confirmed, one during Late Cretaceous (Turonian-Coniacian) and the second around the Eocene-Oligocene boundary with a gap and intense chemical erosion from 75 Ma and mainly from 65 to 40 Ma.

The Threat of Unexamined Secondary Data: A Critical Race Transformative Convergent Mixed Methods

ERIC Educational Resources Information Center

Garcia, Nichole M.; Mayorga, Oscar J.

2018-01-01

This article uses a critical race theory framework to conceptualize a Critical Race Transformative Convergent Mixed Methods (CRTCMM) in education. CRTCMM is a methodology that challenges normative educational research practices by acknowledging that racism permeates educational institutions and marginalizes Communities of Color. The focus of this…

SU-F-J-17: Patient Localization Using MRI-Guided Soft Tissue for Head-And-Neck Radiotherapy: Indication for Margin Reduction and Its Feasibility

DOE Office of Scientific and Technical Information (OSTI.GOV)

Qi, X; Yang, Y; Jack, N

Purpose: On-board MRI provides superior soft-tissue contrast, allowing patient alignment using tumor or nearby critical structures. This study aims to study H&N MRI-guided IGRT to analyze inter-fraction patient setup variations using soft-tissue targets and design appropriate CTV-to-PTV margin and clinical implication. Methods: 282 MR images for 10 H&N IMRT patients treated on a ViewRay system were retrospectively analyzed. Patients were immobilized using a thermoplastic mask on a customized headrest fitted in a radiofrequency coil and positioned to soft-tissue targets. The inter-fraction patient displacements were recorded to compute the PTV margins using the recipe: 2.5∑+0.7σ. New IMRT plans optimized on themore » revised PTVs were generated to evaluate the delivered dose distributions. An in-house dose deformation registration tool was used to assess the resulting dosimetric consequences when margin adaption is performed based on weekly MR images. The cumulative doses were compared to the reduced margin plans for targets and critical structures. Results: The inter-fraction displacements (and standard deviations), ∑ and σ were tabulated for MRI and compared to kVCBCT. The computed CTV-to-PTV margin was 3.5mm for soft-tissue based registration. There were minimal differences between the planned and delivered doses when comparing clinical and the PTV reduced margin plans: the paired t-tests yielded p=0.38 and 0.66 between the planned and delivered doses for the adapted margin plans for the maximum cord and mean parotid dose, respectively. Target V95 received comparable doses as planned for the reduced margin plans. Conclusion: The 0.35T MRI offers acceptable soft-tissue contrast and good spatial resolution for patient alignment and target visualization. Better tumor conspicuity from MRI allows soft-tissue based alignments with potentially improved accuracy, suggesting a benefit of margin reduction for H&N radiotherapy. The reduced margin plans (i.e., 2 mm

17 CFR 242.403 - Required margin.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 17 Commodity and Securities Exchanges 3 2010-04-01 2010-04-01 false Required margin. 242.403 Section 242.403 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION (CONTINUED) REGULATIONS M, SHO, ATS, AC, AND NMS AND CUSTOMER MARGIN REQUIREMENTS FOR SECURITY FUTURES Customer Margin...

Sensitivity of postplanning target and OAR coverage estimates to dosimetric margin distribution sampling parameters

DOE Office of Scientific and Technical Information (OSTI.GOV)

Xu Huijun; Gordon, J. James; Siebers, Jeffrey V.

2011-02-15

Purpose: A dosimetric margin (DM) is the margin in a specified direction between a structure and a specified isodose surface, corresponding to a prescription or tolerance dose. The dosimetric margin distribution (DMD) is the distribution of DMs over all directions. Given a geometric uncertainty model, representing inter- or intrafraction setup uncertainties or internal organ motion, the DMD can be used to calculate coverage Q, which is the probability that a realized target or organ-at-risk (OAR) dose metric D{sub v} exceeds the corresponding prescription or tolerance dose. Postplanning coverage evaluation quantifies the percentage of uncertainties for which target and OAR structuresmore » meet their intended dose constraints. The goal of the present work is to evaluate coverage probabilities for 28 prostate treatment plans to determine DMD sampling parameters that ensure adequate accuracy for postplanning coverage estimates. Methods: Normally distributed interfraction setup uncertainties were applied to 28 plans for localized prostate cancer, with prescribed dose of 79.2 Gy and 10 mm clinical target volume to planning target volume (CTV-to-PTV) margins. Using angular or isotropic sampling techniques, dosimetric margins were determined for the CTV, bladder and rectum, assuming shift invariance of the dose distribution. For angular sampling, DMDs were sampled at fixed angular intervals {omega} (e.g., {omega}=1 deg., 2 deg., 5 deg., 10 deg., 20 deg.). Isotropic samples were uniformly distributed on the unit sphere resulting in variable angular increments, but were calculated for the same number of sampling directions as angular DMDs, and accordingly characterized by the effective angular increment {omega}{sub eff}. In each direction, the DM was calculated by moving the structure in radial steps of size {delta}(=0.1,0.2,0.5,1 mm) until the specified isodose was crossed. Coverage estimation accuracy {Delta}Q was quantified as a function of the sampling parameters

Changes in ice-margin processes and sediment routing during ice-sheet advance across a marginal moraine

USGS Publications Warehouse

Knight, P.G.; Jennings, C.E.; Waller, R.I.; Robinson, Z.P.

2007-01-01

Advance of part of the margin of the Greenland ice sheet across a proglacial moraine ridge between 1968 and 2002 caused progressive changes in moraine morphology, basal ice formation, debris release, ice-marginal sediment storage, and sediment transfer to the distal proglacial zone. When the ice margin is behind the moraine, most of the sediment released from the glacier is stored close to the ice margin. As the margin advances across the moraine the potential for ice-proximal sediment storage decreases and distal sediment flux is augmented by reactivation of moraine sediment. For six stages of advance associated with distinctive glacial and sedimentary processes we describe the ice margin, the debris-rich basal ice, debris release from the glacier, sediment routing into the proglacial zone, and geomorphic processes on the moraine. The overtopping of a moraine ridge is a significant glaciological, geomorphological and sedimentological threshold in glacier advance, likely to cause a distinctive pulse in distal sediment accumulation rates that should be taken into account when glacial sediments are interpreted to reconstruct glacier fluctuations. ?? 2007 Swedish Society for Anthropology and Geography.

Quantitative Segmentation of Fluorescence Microscopy Images of Heterogeneous Tissue: Application to the Detection of Residual Disease in Tumor Margins

PubMed Central

Mueller, Jenna L.; Harmany, Zachary T.; Mito, Jeffrey K.; Kennedy, Stephanie A.; Kim, Yongbaek; Dodd, Leslie; Geradts, Joseph; Kirsch, David G.; Willett, Rebecca M.; Brown, J. Quincy; Ramanujam, Nimmi

2013-01-01

Purpose To develop a robust tool for quantitative in situ pathology that allows visualization of heterogeneous tissue morphology and segmentation and quantification of image features. Materials and Methods Tissue excised from a genetically engineered mouse model of sarcoma was imaged using a subcellular resolution microendoscope after topical application of a fluorescent anatomical contrast agent: acriflavine. An algorithm based on sparse component analysis (SCA) and the circle transform (CT) was developed for image segmentation and quantification of distinct tissue types. The accuracy of our approach was quantified through simulations of tumor and muscle images. Specifically, tumor, muscle, and tumor+muscle tissue images were simulated because these tissue types were most commonly observed in sarcoma margins. Simulations were based on tissue characteristics observed in pathology slides. The potential clinical utility of our approach was evaluated by imaging excised margins and the tumor bed in a cohort of mice after surgical resection of sarcoma. Results Simulation experiments revealed that SCA+CT achieved the lowest errors for larger nuclear sizes and for higher contrast ratios (nuclei intensity/background intensity). For imaging of tumor margins, SCA+CT effectively isolated nuclei from tumor, muscle, adipose, and tumor+muscle tissue types. Differences in density were correctly identified with SCA+CT in a cohort of ex vivo and in vivo images, thus illustrating the diagnostic potential of our approach. Conclusion The combination of a subcellular-resolution microendoscope, acriflavine staining, and SCA+CT can be used to accurately isolate nuclei and quantify their density in anatomical images of heterogeneous tissue. PMID:23824589

Whose banner are we waving? Exploring STEM partnerships for marginalized urban youth

NASA Astrophysics Data System (ADS)

Ridgeway, Monica L.; Yerrick, Randy K.

2018-03-01

This case study examines after school programming in citizen science from the perspective of Critical Race Theory. During the course of enacting community outreach projects this data was used to examine the positioning of experts, student, and teachers within the program. This study explores the role of race and ethnicity, and the ways in which marginalization can manifest itself with black urban youth and teachers. Implications for partner selection and training are addressed.

Missing Stories: The Messy Processes, Multifaceted Risks, & Multiple Roles of Critical Ethnographers

ERIC Educational Resources Information Center

Howard, Joy; Thompson, Candace; Nash, Kindel; Rodriguez, Sophia

2016-01-01

In this article, four critical ethnographers reflect on dilemmas that arose during individual research projects. We grappled with the question: What does critical ethnography require from us as we work to represent stories that emerge in contexts where students and/or teachers have been marginalized? After engaging in a three-year process of…

Diminishing Marginal Utility in Economics Textbooks

ERIC Educational Resources Information Center

Dittmer, Timothy

2005-01-01

Many introductory microeconomics textbook authors derive the law of demand from the assumption of diminishing marginal utility. Authors of intermediate and graduate textbooks derive demand from diminishing marginal rate of substitution and ordinal preferences. These approaches are not interchangeable; diminishing marginal utility for all goods is…

The Infeasibility of Quantifying the Reliability of Life-Critical Real-Time Software

NASA Technical Reports Server (NTRS)

Butler, Ricky W.; Finelli, George B.

1991-01-01

This paper affirms that the quantification of life-critical software reliability is infeasible using statistical methods whether applied to standard software or fault-tolerant software. The classical methods of estimating reliability are shown to lead to exhorbitant amounts of testing when applied to life-critical software. Reliability growth models are examined and also shown to be incapable of overcoming the need for excessive amounts of testing. The key assumption of software fault tolerance separately programmed versions fail independently is shown to be problematic. This assumption cannot be justified by experimentation in the ultrareliability region and subjective arguments in its favor are not sufficiently strong to justify it as an axiom. Also, the implications of the recent multiversion software experiments support this affirmation.

Splenic marginal zone lymphoma.

PubMed

Piris, Miguel A; Onaindía, Arantza; Mollejo, Manuela

Splenic marginal zone lymphoma (SMZL) is an indolent small B-cell lymphoma involving the spleen and bone marrow characterized by a micronodular tumoral infiltration that replaces the preexisting lymphoid follicles and shows marginal zone differentiation as a distinctive finding. SMZL cases are characterized by prominent splenomegaly and bone marrow and peripheral blood infiltration. Cells in peripheral blood show a villous cytology. Bone marrow and peripheral blood characteristic features usually allow a diagnosis of SMZL to be performed. Mutational spectrum of SMZL identifies specific findings, such as 7q loss and NOTCH2 and KLF2 mutations, both genes related with marginal zone differentiation. There is a striking clinical variability in SMZL cases, dependent of the tumoral load and performance status. Specific molecular markers such as 7q loss, p53 loss/mutation, NOTCH2 and KLF2 mutations have been found to be associated with the clinical variability. Distinction from Monoclonal B-cell lymphocytosis with marginal zone phenotype is still an open issue that requires identification of precise and specific thresholds with clinical meaning. Copyright © 2016 Elsevier Ltd. All rights reserved.

Quantifying denudation of the West African passive-transform margin: implications for Cenozoic erosion budget of cratons and source-to-sink systems

NASA Astrophysics Data System (ADS)

Grimaud, Jean-Louis; Chardon, Dominique; Rouby, Delphine; Beauvais, Anicet

2014-05-01

We develop an approach based on the differential elevation of dated successive topographies of the onshore part of the West African margin to calibrate in-situ volumetric denudation over a 3.9 million km2 cratonic surface for the past 45 Ma. We obtain a regionally averaged volumetric erosion rate of 5 x 10-3 km3/km2/m.y. corresponding to a total average denudation of 300 m and a denudation rate of 6 m/m.y., which remained nearly constant over the three time spans (45- 24, 24-11 and 11-0 Ma) despite spatial variations related to epeirogenic movements. Denudation is converted into a minimum yield of 12 +/- 2 t/km2/yr with a minimum solute component of 4 +/- 2 t/km2/yr accounting for the porosity of the eroded regoliths. Our results would imply a minimum contribution of 1.6 +/- 0.4 Gt/yr of the non-orogenic landmass to the global continental yield since the last peak greenhouse. Reconstruction of two incision stages of West Africa landscape from the reconstructed topographies combined with paleogeographic data shows that the current river catchments of the sub region have acquired their current configuration by the end of the Oligocene at the latest (24 Ma ago). The fairly steady geometry of the West African drainage since then offers the opportunity to effectively link the inland geomorphic record to offshore sedimentation. Volumetric denudation analysis applied to West African sub-drainage areas attests to the role of drainage reorganization and epeirogenic mouvements (flexural growth of the marginal upwarp and amplification of the Hoggar intraplate swell) on the spatial and temporal distribution of continental denudation and yield. Onshore denudation and clastic sediments accumulation in the post-24 Ma Niger catchment - delta system are within the same order of magnitude. These results suggest that cratonic-type erosion fluxes estimated from the West African margin may be used to estimate the size of drainage basins from the fossil sedimentary record.

Fine Ice Sheet margins topography from swath processing of CryoSat SARIn mode data

NASA Astrophysics Data System (ADS)

Gourmelen, N.; Escorihuela, M. J.; Shepherd, A.; Foresta, L.; Muir, A.; Briggs, K.; Hogg, A. E.; Roca, M.; Baker, S.; Drinkwater, M. R.

2014-12-01

Reference and repeat-observations of Glacier and Ice Sheet Margin (GISM) topography are critical to identify changes in ice thickness, provide estimates of mass gain or loss and thus quantify the contribution of the cryosphere to sea level change. The lack of such sustained observations was identified in the Integrated Global Observing Strategy (IGOS) Cryosphere Theme Report as a major shortcoming. Conventional altimetry measurements over GISMs exist, but coverage has been sparse and characterized by coarse ground resolution. Additionally, and more importantly, they proved ineffective in the presence of steep slopes, a typical feature of GISM areas. Since the majority of Antarctic and Greenland ice sheet mass loss is estimated to lie within 100 km from the coast, but only about 10% is surveyed, there is the need for more robust and dense observations of GISMs, in both time and space. The ESA Altimetry mission CryoSat aims at gaining better insight into the evolution of the Cryosphere. CryoSat's revolutionary design features a Synthetic Interferometric Radar Altimeter (SIRAL), with two antennas for interferometry. The corresponding SAR Interferometer (SARIn) mode of operation increases spatial resolution while resolving the angular origin of off-nadir echoes occurring over sloping terrain. The SARIn mode is activated over GISMs and the elevation for the Point Of Closest Approach (POCA) is a standard product of the CryoSat mission. Here we present an approach for more comprehensively exploiting the SARIn mode of CryoSat and produce an ice elevation product with enhanced spatial resolution compared to standard CryoSat-2 height products. In this so called L2-swath processing approach, the full CryoSat waveform is exploited under specific conditions of signal and surface characteristics. We will present the rationale, validation exercises and preliminary results from the Eurpean Space Agency's STSE CryoTop study over selected test regions of the margins of the Greenland

On the marginal instability threshold condition of the aperiodic ordinary mode

DOE Office of Scientific and Technical Information (OSTI.GOV)

Schlickeiser, R.; Yoon, P. H.; School of Space Research, Kyung Hee University, Yongin

2014-07-15

The purely growing ordinary (O) mode instability has recently received renewed attention owing to its potential applicability to the solar wind plasma. Here, an analytical marginal instability condition is derived for counter-streaming bi-Maxwellian plasma particle distribution functions. The derived marginal instability condition as a function of the temperature anisotropy and plasma beta agrees remarkably well with the numerically determined instability condition. The existence of a new instability domain of the O-mode at small plasma beta values is confirmed with the leading A∝β{sub ∥}{sup −1}-dependence, if the counter-stream parameter P{sub e} exceeds a critical value. At small plasma beta values atmore » large enough counter-stream parameter, the O-mode also operates for temperature anisotropies A = T{sub ⊥}/T{sub ∥} > 1 even larger than unity, as the parallel counter-stream free energy exceeds the perpendicular bi-Maxwellian free energy.« less

Orientational preferences of neighboring helices can drive ER insertion of a marginally hydrophobic transmembrane helix

PubMed Central

Öjemalm, Karin; Halling, Katrin K.; Nilsson, IngMarie; von Heijne, Gunnar

2013-01-01

Summary α-helical integral membrane proteins critically depend on the correct insertion of their transmembrane α-helices into the lipid bilayer for proper folding, yet a surprisingly large fraction of the transmembrane α-helices in multispanning integral membrane proteins are not sufficiently hydrophobic to insert into the target membrane by themselves. How can such marginally hydrophobic segments nevertheless form transmembrane helices in the folded structure? Here, we show that a transmembrane helix with a strong orientational preference (Ncyt-Clum or Nlum-Ccyt) can both increase and decrease the hydrophobicity threshold for membrane insertion of a neighboring, marginally hydrophobic helix. This effect helps explain the ‘missing hydrophobicity’ in polytopic membrane proteins. PMID:22281052

The marginal band system in nymphalid butterfly wings.

PubMed

Taira, Wataru; Kinjo, Seira; Otaki, Joji M

2015-01-01

Butterfly wing color patterns are highly complex and diverse, but they are believed to be derived from the nymphalid groundplan, which is composed of several color pattern systems. Among these pattern systems, the marginal band system, including marginal and submarginal bands, has rarely been studied. Here, we examined the color pattern diversity of the marginal band system among nymphalid butterflies. Marginal and submarginal bands are usually expressed as a pair of linear bands aligned with the wing margin. However, a submarginal band can be expressed as a broken band, an elongated oval, or a single dot. The marginal focus, usually a white dot at the middle of a wing compartment along the wing edge, corresponds to the pupal edge spot, one of the pupal cuticle spots that signify the locations of color pattern organizing centers. A marginal band can be expressed as a semicircle, an elongated oval, or a pair of eyespot-like structures, which suggest the organizing activity of the marginal focus. Physical damage at the pupal edge spot leads to distal dislocation of the submarginal band in Junonia almana and in Vanessa indica, suggesting that the marginal focus functions as an organizing center for the marginal band system. Taken together, we conclude that the marginal band system is developmentally equivalent to other symmetry systems. Additionally, the marginal band is likely a core element and the submarginal band a paracore element of the marginal band system, and both bands are primarily specified by the marginal focus organizing center.

Speech and Writing in Poetry and Its Criticism.

ERIC Educational Resources Information Center

Bradford, Richard

1988-01-01

Examines how literary criticism exploits and marginalizes the poem as printed artifact. Argues that the author-centered, phonocentric premise of close reading neutralizes spatial dynamics and reduces material identity to the status of a transparent medium. Suggests that appreciation of silent visual form is a convention of post modernist writing.…

Dismantling the Silence: LGBTQ Aging Emerging From the Margins

PubMed Central

Fredriksen-Goldsen, Karen I.

2017-01-01

Historical, environmental, and cultural contexts intersect with aging, sexuality, and gender across communities and generations. My scholarship investigates health and well-being over the life course across marginalized communities, including LGBTQ (lesbian, gay, bisexual, transgender, and queer) midlife and older adults, native communities experiencing cardiovascular risk, and families in China living with HIV, in order to balance the realities of unique lives in contemporary society. By probing the intersection of age, sexuality, and gender, my analysis is informed by both personal and professional experiences. With the death of my partner occurring at a time of profound invisibility and silence before HIV/AIDS, I found my life out of sync, experiencing a loss without a name. My life was thrust into a paradox: My relationship was defined by a world that refused to recognize it. This essay provides an opportunity for me to weave together how such critical turning points in my own life helped shape my approach to gerontology and how gerontology has informed my work and life. Reflecting on this journey, I illustrate the ways in which historical, structural, environmental, psychosocial, and biological factors affect equity, and the health-promoting and adverse pathways to health and well-being across marginalized communities. Although gerontology as a discipline has historically silenced the lives of marginalized older adults, it has much to learn from these communities. The growing and increasingly diverse older adult population provides us with unique opportunities to better understand both cultural variations and shared experiences in aging over the life course. PMID:28053011

Critical consciousness: current status and future directions.

PubMed

Watts, Roderick J; Diemer, Matthew A; Voight, Adam M

2011-01-01

In this chapter, the authors consider Paulo Freire's construct of critical consciousness (CC) and why it deserves more attention in research and discourse on youth political and civic development. His approach to education and similar ideas by other scholars of liberation aims to foster a critical analysis of society--and one's status within it--using egalitarian, empowering, and interactive methods. The aim is social change as well as learning, which makes these ideas especially relevant to the structural injustice faced by marginalized youth. From their review of these ideas, the authors derive three core CC components: critical reflection, political efficacy, and critical action. They highlight promising research related to these constructs and innovative applied work including youth action-research methodology. Their conclusion offers ideas for closing some of the critical gaps in CC theory and research. Copyright © 2011 Wiley Periodicals, Inc., A Wiley Company.

Geomorphology of the Iberian Continental Margin

NASA Astrophysics Data System (ADS)

Maestro, Adolfo; López-Martínez, Jerónimo; Llave, Estefanía; Bohoyo, Fernando; Acosta, Juan; Hernández-Molina, F. Javier; Muñoz, Araceli; Jané, Gloria

2013-08-01

The submarine features and processes around the Iberian Peninsula are the result of a complex and diverse geological and oceanographical setting. This paper presents an overview of the seafloor geomorphology of the Iberian Continental Margin and the adjacent abyssal plains. The study covers an area of approximately 2.3 million km2, including a 50 to 400 km wide band adjacent to the coastline. The main morphological characteristics of the seafloor features on the Iberian continental shelf, continental slope, continental rise and the surrounding abyssal plains are described. Individual seafloor features existing on the Iberian Margin have been classified into three main groups according to their origin: tectonic and/or volcanic, depositional and erosional. Major depositional and erosional features around the Iberian Margin developed in late Pleistocene-Holocene times and have been controlled by tectonic movements and eustatic fluctuations. The distribution of the geomorphological features is discussed in relation to their genetic processes and the evolution of the margin. The prevalence of one or several specific processes in certain areas reflects the dominant morphotectonic and oceanographic controlling factors. Sedimentary processes and the resulting depositional products are dominant on the Valencia-Catalán Margin and in the northern part of the Balearic Promontory. Strong tectonic control is observed in the geomorphology of the Betic and the Gulf of Cádiz margins. The role of bottom currents is especially evident throughout the Iberian Margin. The Galicia, Portuguese and Cantabrian margins show a predominance of erosional features and tectonically-controlled linear features related to faults.

Transforming Education, Transforming Society: The Co-Construction of Critical Peace Education and Indigenous Education

ERIC Educational Resources Information Center

Sumida Huaman, Elizabeth

2011-01-01

This article seeks to contribute to the link between critical peace education and Indigenous education from an Indigenous international and comparative education perspective. The article first reviews the marginalization of critical peace education and Indigenous education. By bringing forward areas of common interest between peace education and…

The availability and economic analyses of using marginal land for bioenergy production in China

NASA Astrophysics Data System (ADS)

Yuqi, Chen; Xudong, Guo; Chunyan, Lv

2017-04-01

In recent years, China has witnessed rapid increase in the dependence of foreign oil import. In 2015, the primary energy consumption of China is 543 million tons, of which 328 million tons was imported. The total amount of imported foreign oil increased from 49.8% in 2008 to 60.41% in 2016. To address the national energy security and GHG emission reduction, China has made considerable progress in expanding renewable energy portfolio, especially liquid biofuels. However, under the pressure of high population and vulnerable food security, China's National Development and Reform Commission (NDRC) ruled that bioenergy is only allowed to be produced using non-cereal feedstock. In addition, the energy crops can only be planted on marginal land, which is the land not suitable for growing field crops due to edaphic and/or climatic limitations, and other environmental risks. Although there have been a number of studies about estimating the marginal land for energy plants' cultivation in China, as to the different definition of marginal land and land use data, the results are quite different. Furthermore, even if there is enough marginal land suitable for energy plants' cultivation, economic viability of cultivating energy plants on marginal land is critical. In order to analyze the availability and economic analyses of the marginal land for bioenergy production strategy, firstly, by using of the latest and most authoritative land use data, this study focused on the assessment of marginal land resources and bioenergy potential by planting five species of energy plants including Cassava, Jatropha curcas, Helianthus tuberous L, Pistacia chinensis, Xanthoceras sorbifolia Bunge. The results indicate that there are 289.71 million ha marginal land can be used for these five energy plants' cultivation, which can produce 24.45 million tons bioethanol and 8.77 million tons of biodiesel. Secondly, based on field survey data and literature reviews, we found that, from the farmers

Robust Flutter Margin Analysis that Incorporates Flight Data

NASA Technical Reports Server (NTRS)

Lind, Rick; Brenner, Martin J.

1998-01-01

An approach for computing worst-case flutter margins has been formulated in a robust stability framework. Uncertainty operators are included with a linear model to describe modeling errors and flight variations. The structured singular value, mu, computes a stability margin that directly accounts for these uncertainties. This approach introduces a new method of computing flutter margins and an associated new parameter for describing these margins. The mu margins are robust margins that indicate worst-case stability estimates with respect to the defined uncertainty. Worst-case flutter margins are computed for the F/A-18 Systems Research Aircraft using uncertainty sets generated by flight data analysis. The robust margins demonstrate flight conditions for flutter may lie closer to the flight envelope than previously estimated by p-k analysis.

Continental Margins of the Arctic Ocean: Implications for Law of the Sea

NASA Astrophysics Data System (ADS)

Mosher, David

2016-04-01

A coastal State must define the outer edge of its continental margin in order to be entitled to extend the outer limits of its continental shelf beyond 200 M, according to article 76 of the UN Convention on the Law of the Sea. The article prescribes the methods with which to make this definition and includes such metrics as water depth, seafloor gradient and thickness of sediment. Note the distinction between the "outer edge of the continental margin", which is the extent of the margin after application of the formula of article 76, and the "outer limit of the continental shelf", which is the limit after constraint criteria of article 76 are applied. For a relatively small ocean basin, the Arctic Ocean reveals a plethora of continental margin types reflecting both its complex tectonic origins and its diverse sedimentation history. These factors play important roles in determining the extended continental shelves of Arctic coastal States. This study highlights the critical factors that might determine the outer edge of continental margins in the Arctic Ocean as prescribed by article 76. Norway is the only Arctic coastal State that has had recommendations rendered by the Commission on the Limits of the Continental Shelf (CLCS). Russia and Denmark (Greenland) have made submissions to the CLCS to support their extended continental shelves in the Arctic and are awaiting recommendations. Canada has yet to make its submission and the US has not yet ratified the Convention. The various criteria that each coastal State has utilized or potentially can utilize to determine the outer edge of the continental margin are considered. Important criteria in the Arctic include, 1) morphological continuity of undersea features, such as the various ridges and spurs, with the landmass, 2) the tectonic origins and geologic affinities with the adjacent land masses of the margins and various ridges, 3) sedimentary processes, particularly along continental slopes, and 4) thickness and

Abrupt plate acceleration during rifted margin formation: Cause and effect

NASA Astrophysics Data System (ADS)

Brune, Sascha; Williams, Simon; Butterworth, Nathaniel; Müller, Dietmar

2017-04-01

Extension rate is known to control key processes during rifted margin formation such as crust-mantle coupling, decompression melting, magmatism, and serpentinisation. Here we build on recent advances in plate tectonic reconstructions by quantifying the extension velocity history of Earth's major rifted margins during the last 240 million years. We find that many successful rifts start with a slow phase of extension followed by rapid acceleration that introduces a fast phase. The transition from slow to fast rifting takes place long before crustal break-up: approximately half of the present day rifted margin area was created during the slow, and the other half during the fast rift phase. We reproduce the rapid transition from slow to fast extension using analytical and numerical modelling with constant force boundary conditions. In these models, rift velocities are not imposed but instead evolve naturally in response to the changing strength of the rift. Our results demonstrate that abrupt plate acceleration during continental rifting is controlled by a rift-intrinsic strength-velocity feedback. The abruptness of rift acceleration is thereby governed by the nonlinearity of lithospheric localization. Realistic brittle and power-law rheologies lead to a speed-up duration between two and ten million years. For successful rifts that generate a new ocean basin, the duration of rift speed-up is notably almost independent of the applied extensional force. Instead, the force controls the duration of the slow phase: higher forces shorten the slow phase while lower forces prolong it. If the force is too low, however, delocalisation processes prevent the rift from reaching the point of speed-up and produce a failed rift, even if the extensional system was active for many million years.

MARGINS: Toward a novel science plan

NASA Astrophysics Data System (ADS)

Mutter, John C.

A science plan to study continental margins has been in the works for the past 3 years, with almost 200 Earth scientists from a wide variety of disciplines gathering at meetings and workshops. Most geological hazards and resources are found at continental margins, yet our understanding of the processes that shape the margins is meager.In formulating this MARGINS research initiative, fundamental issues concerning our understanding of basic Earth-forming processes have arisen. It is clear that a business-as-usual approach will not solve the class of problems defined by the MARGINS program; the solutions demand approaches different from those used in the past. In many cases, a different class of experiment will be required, one that is well beyond the capability of individual principle investigators to undertake on their own. In most cases, broadly based interdisciplinary studies will be needed.

Quantifying the relationship between vehicle interior geometry and child restraint systems.

PubMed

Sherwood, C P; Abdelilah, Y; Crandall, J R

2006-01-01

The prevention of interactions of children or child restraints with other vehicle structures is critical to child passenger safety. Fifteen current vehicles and seven rear and forward facing child restraint systems were measured in an attempt to quantify the available distance between child restraints and these vehicle structures. Rear facing child restraints exhibited such small amounts of clearance that contact would be expected in the majority of frontal crashes. Upper tethers are critical in the prevention of head contact, while head contact is likely when the upper tether is not used.

Tumor margin detection using optical biopsy techniques

NASA Astrophysics Data System (ADS)

Zhou, Yan; Liu, Cheng-hui; Li, Jiyou; Li, Zhongwu; Zhou, Lixin; Chen, Ke; Pu, Yang; He, Yong; Zhu, Ke; Li, Qingbo; Alfano, Robert R.

2014-03-01

The aim of this study is to use the Resonance Raman (RR) and fluorescence spectroscopic technique for tumor margin detection with high accuracy based on native molecular fingerprints of breast and gastrointestinal (GI) tissues. This tumor margins detection method utilizes advantages of RR spectroscopic technique in situ and in real-time to diagnose tumor changes providing powerful tools for clinical guiding intraoperative margin assessments and postoperative treatments. The tumor margin detection procedures by RR spectroscopy were taken by scanning lesion from center or around tumor region in ex-vivo to find the changes in cancerous tissues with the rim of normal tissues using the native molecular fingerprints. The specimens used to analyze tumor margins include breast and GI carcinoma and normal tissues. The sharp margin of the tumor was found by the changes of RR spectral peaks within 2 mm distance. The result was verified using fluorescence spectra with 300 nm, 320 nm and 340 nm excitation, in a typical specimen of gastric cancerous tissue within a positive margin in comparison with normal gastric tissues. This study demonstrates the potential of RR and fluorescence spectroscopy as new approaches with labeling free to determine the intraoperative margin assessment.

Critical Care Organizations: Business of Critical Care and Value/Performance Building.

PubMed

Leung, Sharon; Gregg, Sara R; Coopersmith, Craig M; Layon, A Joseph; Oropello, John; Brown, Daniel R; Pastores, Stephen M; Kvetan, Vladimir

2018-01-01

New, value-based regulations and reimbursement structures are creating historic care management challenges, thinning the margins and threatening the viability of hospitals and health systems. The Society of Critical Care Medicine convened a taskforce of Academic Leaders in Critical Care Medicine on February 22, 2016, during the 45th Critical Care Congress to develop a toolkit drawing on the experience of successful leaders of critical care organizations in North America for advancing critical care organizations (Appendix 1). The goal of this article was to provide a roadmap and call attention to key factors that adult critical care medicine leadership in both academic and nonacademic setting should consider when planning for value-based care. Relevant medical literature was accessed through a literature search. Material published by federal health agencies and other specialty organizations was also reviewed. Collaboratively and iteratively, taskforce members corresponded by electronic mail and held monthly conference calls to finalize this report. The business and value/performance critical care organization building section comprised of leaders of critical care organizations with expertise in critical care administration, healthcare management, and clinical practice. Two phases of critical care organizations care integration are described: "horizontal," within the system and regionalization of care as an initial phase, and "vertical," with a post-ICU and postacute care continuum as a succeeding phase. The tools required for the clinical and financial transformation are provided, including the essential prerequisites of forming a critical care organization; the manner in which a critical care organization can help manage transformational domains is considered. Lastly, how to achieve organizational health system support for critical care organization implementation is discussed. A critical care organization that incorporates functional clinical horizontal and

A simulation study of spectral Čerenkov luminescence imaging for tumour margin estimation

NASA Astrophysics Data System (ADS)

Calvert, Nick; Helo, Yusef; Mertzanidou, Thomy; Tuch, David S.; Arridge, Simon R.; Stoyanov, Danail

2017-03-01

Breast cancer is the most common cancer in women in the world. Breast-conserving surgery (BCS) is a standard surgical treatment for breast cancer with the key objective of removing breast tissue, maintaining a negative surgical margin and providing a good cosmetic outcome. A positive surgical margin, meaning the presence of cancerous tissues on the surface of the breast specimen after surgery, is associated with local recurrence after therapy. In this study, we investigate a new imaging modality based on Cerenkov luminescence imaging (CLI) for the purpose of detecting positive surgical margins during BCS. We develop Monte Carlo (MC) simulations using the Geant4 nuclear physics simulation toolbox to study the spectrum of photons emitted given 18F-FDG and breast tissue properties. The resulting simulation spectra show that the CLI signal contains information that may be used to estimate whether the cancerous cells are at a depth of less than 1 mm or greater than 1 mm given appropriate imaging system design and sensitivity. The simulation spectra also show that when the source is located within 1 mm of the surface, the tissue parameters are not relevant to the model as the spectra do not vary significantly. At larger depths, however, the spectral information varies significantly with breast optical parameters, having implications for further studies and system design. While promising, further studies are needed to quantify the CLI response to more accurately incorporate tissue specific parameters and patient specific anatomical details.

Probabilistic margin evaluation on accidental transients for the ASTRID reactor project

NASA Astrophysics Data System (ADS)

Marquès, Michel

2014-06-01

ASTRID is a technological demonstrator of Sodium cooled Fast Reactor (SFR) under development. The conceptual design studies are being conducted in accordance with the Generation IV reactor objectives, particularly in terms of improving safety. For the hypothetical events, belonging to the accidental category "severe accident prevention situations" having a very low frequency of occurrence, the safety demonstration is no more based on a deterministic demonstration with conservative assumptions on models and parameters but on a "Best-Estimate Plus Uncertainty" (BEPU) approach. This BEPU approach ispresented in this paper for an Unprotected Loss-of-Flow (ULOF) event. The Best-Estimate (BE) analysis of this ULOFt ransient is performed with the CATHARE2 code, which is the French reference system code for SFR applications. The objective of the BEPU analysis is twofold: first evaluate the safety margin to sodium boiling in taking into account the uncertainties on the input parameters of the CATHARE2 code (twenty-two uncertain input parameters have been identified, which can be classified into five groups: reactor power, accident management, pumps characteristics, reactivity coefficients, thermal parameters and head losses); secondly quantify the contribution of each input uncertainty to the overall uncertainty of the safety margins, in order to refocusing R&D efforts on the most influential factors. This paper focuses on the methodological aspects of the evaluation of the safety margin. At least for the preliminary phase of the project (conceptual design), a probabilistic criterion has been fixed in the context of this BEPU analysis; this criterion is the value of the margin to sodium boiling, which has a probability 95% to be exceeded, obtained with a confidence level of 95% (i.e. the M5,95percentile of the margin distribution). This paper presents two methods used to assess this percentile: the Wilks method and the Bootstrap method ; the effectiveness of the two methods

A Critical Perspective of Contemporary Unemployment Policy and Practices

ERIC Educational Resources Information Center

Blustein, David L.; Medvide, Mary Beth; Wan, Carol M.

2012-01-01

This article explores the challenges of unemployment via the lens of critical psychology. The conventional discourse on unemployment is critiqued, revealing ways in which conventional policies and practices serve to further marginalize the lives of the unemployed and impede the development of ethical, effective, and empathic individual…

The impact of surgery on survival of patients with cutaneous melanoma: revisiting the role of primary tumor excision margins.

PubMed

Mocellin, Simone; Pasquali, Sandro; Nitti, Donato

2011-02-01

To quantify the impact of excision margins on disease-specific survival of patients with primary cutaneous melanoma. Current guidelines recommend narrow margins for the treatment of primary melanoma, although available evidence on this subject is not unequivocal and not always appropriately analyzed. A systematic review of randomized controlled trials (RCT) addressing the issue of wide versus narrow excision margins was performed. Meta-analysis methods for time-to-event data were used to extract hazard ratios(HR) and their 95% confidence intervals (CI) from eligible studies, and ultimately to estimate the summary effect of excision margins on patients' survival. The 5 eligible RCT enrolled a total of 3295 patients who were allocated to wide (3-5 cm) or narrow (1-2 cm) excision of their primary tumor. The data of locoregional disease-free (LDFS), disease-free (DFS),disease-specific (DSS), and overall (OS) survival were available for 3, 5, 3, and 5 RCT, respectively. The meta-analysis suggested that narrow margins might be associated with an increased risk of both locoregional disease recurrence (HR: 1.30, CI: 1.07-1.57; P = 0.01) and death by disease (HR: 1.28, CI:1.07-1.53, P = 0.01). As regards DFS, the borderline disadvantage (HR:1.13, CI: 0.995-1.28; P = 0.06) becomes significant when considering RCT that enrolled patients with thicker melanoma (HR: 1.19, CI: 1.02-1.39, P =0.03). When death by any cause (OS) was analyzed, no risk difference was found. The lack of DSS data from all the available RCT does not allow to draw definitive conclusions. However, current evidence appears sufficient to question the common belief that narrow excision margins are as safe as wide margins in the management of primary melanoma, that calls for further investigation in this field.

The Eastern Sardinian Margin (Tyrrhenian Sea, Western Mediterranean) : a key area to study the rifting and post-breakup evolution of a back-arc passive continental margin

NASA Astrophysics Data System (ADS)

Gaullier, Virginie; Chanier, Frank; Vendeville, Bruno; Maillard, Agnès; Thinon, Isabelle; Graveleau, Fabien; Lofi, Johanna; Sage, Françoise

2016-04-01

The Eastern Sardinian passive continental margin formed during the opening of the Tyrrhenian Sea, which is a back-arc basin created by continental rifting and oceanic spreading related to the eastward migrating Apennine subduction system (middle Miocene to Pliocene). Up to now, rifting in this key area was considered to be pro parte coeval with the Messinian Salinity Crisis (MSC, 5.96-5.32 Ma). We use the MSC seismic markers and the deformation of viscous salt and its brittle overburden as proxies to better delineate the timing of rifting and post-rift reactivation, and especially to quantify vertical and horizontal movements. On this young, highly-segmented margin, the Messinian Erosion Surface and the Upper and Mobile Units are systematically associated, respectively, to basement highs and deeper basins, showing that a rifted deep-sea domain already existed by Messinian times, therefore a major pre-MSC rifting episode occurred across the entire domain. Data show that there are no signs of Messinian syn-rift sediments, hence no evidence for rifting after Late Tortonian times. Moreover, because salt tectonics creates fan-shaped geometries in sediments, syn-rift deposits have to be carefully re-examined to distinguish the effects of crustal tectonics (rifting) and salt tectonics. We also precise that rifting is clearly diachronous from the upper margin (East-Sardinia Basin) to the lower margin (Cornaglia Terrace) with two unconformities, attributed respectively to the necking and to the lithospheric breakup unconformities. The onshore part of the upper margin has been recently investigated in order to characterize the large crustal faults affecting the Mesozoic series (geometry, kinematics and chronology) and to decipher the role of the structural inheritance and of the early rifting. Seaward, we also try to constrain the architecture and timing of the continent-ocean transition, between the hyper-extended continental crust and the first oceanic crust. Widespread

An Integrative Cultural Model to better situate marginalized science students in postsecondary science education

NASA Astrophysics Data System (ADS)

Labouta, Hagar Ibrahim; Adams, Jennifer Dawn; Cramb, David Thomas

2018-03-01

In this paper we reflect on the article "I am smart enough to study postsecondary science: a critical discourse analysis of latecomers' identity construction in an online forum", by Phoebe Jackson and Gale Seiler (Cult Stud Sci Educ. https://doi.org/10.1007/s11422-017-9818-0). In their article, the authors did a significant amount of qualitative analysis of a discussion on an online forum by four latecomer students with past negative experiences in science education. The students used this online forum as an out-of-class resource to develop a cultural model based on their ability to ask questions together with solidarity as a new optimistic way to position themselves in science. In this forum, we continue by discussing the identity of marginalized science students in relation to resources available in postsecondary science classes. Recent findings on a successful case of a persistent marginalized science student in spite of prior struggles and failures are introduced. Building on their model and our results, we proposed a new cultural model, emphasizing interaction between inside and outside classroom resources which can further our understanding of the identity of marginalized science students. Exploring this cultural model could better explain drop-outs or engagement of marginalized science students to their study. We, then, used this model to reflect on both current traditional and effective teaching and learning practices truncating or re-enforcing relationships of marginalized students with the learning environment. In this way, we aim to further the discussion initiated by Jackson and Seiler and offer possible frameworks for future research on the interactions between marginalized students with past low achievements and other high and mid achieving students, as well as other interactions between resources inside and outside science postsecondary classrooms.

A Write to Know: Using Autoethnographic Writing to Explore Marginalization and Sense of Belonging in Community College Students

ERIC Educational Resources Information Center

Bracamontes, Brent Ignacio

2017-01-01

This dissertation used qualitative, interpretive methods to explore African American and Latino/a community college students' use of autoethnographic writing to express experiences of marginalization and sense of belonging on their college campus. Using postmodernism and critical race theory as theoretical frameworks, I investigated how students…

Critical Pedagogy and Praxis with Native American Youth: Cultivating Change through Participatory Action Research

ERIC Educational Resources Information Center

Groves Price, Paula; Mencke, Paul D.

2013-01-01

The author's used this article to discuss critical pedagogy and praxis, but also provided an example of their work and process of engaging in participatory action research (PAR) with Native American Youth as they navigated through their own tensions of positionality and criticality with historically marginalized teens. They introduce the…

Final Technical Report on Quantifying Dependability Attributes of Software Based Safety Critical Instrumentation and Control Systems in Nuclear Power Plants

DOE Office of Scientific and Technical Information (OSTI.GOV)

Smidts, Carol; Huang, Funqun; Li, Boyuan

With the current transition from analog to digital instrumentation and control systems in nuclear power plants, the number and variety of software-based systems have significantly increased. The sophisticated nature and increasing complexity of software raises trust in these systems as a significant challenge. The trust placed in a software system is typically termed software dependability. Software dependability analysis faces uncommon challenges since software systems’ characteristics differ from those of hardware systems. The lack of systematic science-based methods for quantifying the dependability attributes in software-based instrumentation as well as control systems in safety critical applications has proved itself to be amore » significant inhibitor to the expanded use of modern digital technology in the nuclear industry. Dependability refers to the ability of a system to deliver a service that can be trusted. Dependability is commonly considered as a general concept that encompasses different attributes, e.g., reliability, safety, security, availability and maintainability. Dependability research has progressed significantly over the last few decades. For example, various assessment models and/or design approaches have been proposed for software reliability, software availability and software maintainability. Advances have also been made to integrate multiple dependability attributes, e.g., integrating security with other dependability attributes, measuring availability and maintainability, modeling reliability and availability, quantifying reliability and security, exploring the dependencies between security and safety and developing integrated analysis models. However, there is still a lack of understanding of the dependencies between various dependability attributes as a whole and of how such dependencies are formed. To address the need for quantification and give a more objective basis to the review process -- therefore reducing regulatory

Pathology of nodal marginal zone lymphomas.

PubMed

Pileri, Stefano; Ponzoni, Maurilio

Nodal marginal zone B cell lymphomas (NMZLs) are a rare group of lymphoid disorders part of the spectrum of marginal zone B-cell lymphomas, which encompass splenic marginal one B-cell lymphoma (SMZL) and extra nodal marginal zone of B-cell lymphoma (EMZL), often of MALT-type. Two clinicopathological forms of NMZL are recognized: adult-type and pediatric-type, respectively. NMZLs show overlapping features with other types of MZ, but distinctive features as well. In this review, we will focus on the salient distinguishing features of NMZL mostly under morphological/immunophenotypical/molecular perspectives in views of the recent acquisitions and forthcoming updated 2016 WHO classification of lymphoid malignancies. Copyright © 2016 Elsevier Ltd. All rights reserved.

Seismic influence in the Quaternary uplift of the Central Chile coastal margin, preliminary results.

NASA Astrophysics Data System (ADS)

Valdivia, D.; del Valle, F.; Marquardt, C.; Elgueta, S.

2017-12-01

In order to quantify the influence of NW striking potentially seismogenic normal faults over the longitudinal variation of the Central Chile Coastal margin uplift, we measured Quaternary marine terraces, which represent the tectonic uplift of the coastal margin. Movement in margin oblique normal faults occurs by co-seismic extension of major subduction earthquakes and has occurred in the Pichilemu fault, generating a 7.0 Mw earthquake after the 2010 8.8 Mw Maule earthquake.The coastal area between 32° and 34° S was selected due to the presence of a well-preserved sequence of 2 to 5 Quaternary marine terraces. In particular, the margin oblique normal NW-trending, SW-dipping Laguna Verde fault, south of Valparaiso (33° S) puts in contact contrasting morphologies: to the south, a flat coast with wide marine terraces is carved in both, Jurassic plutonic rocks and Neogene semi-consolidated marine sediments; to the north, a steeper scarp with narrower marine terraces, over 120 m above the corresponding ones in the southern coast, is carved in Jurassic plutonic rocks.We have collected over 6 months microseimic data, providing information on seismic activity and underground geometry of the Laguna Verde fault. We collected ca. 100 systematic measurements of fringes at the base of paleo coastal scarps through field mapping and a 5 m digital elevation model. These fringes mark the maximum sea level during the terrace's carving.The heights of these fringes range between 0 and 250 masl. We estimate a 0.7 mm/yr slip rate for the Laguna Verde fault based on the height difference between corresponding terraces north- and southward, with an average uplift rate of 0.3 mm/yr for the whole area.NW striking normal faults, besides representing a potential seismic threat to the near population on one of the most densely populated areas of Chile, heavily controls the spatial variation of the coastal margin uplift. In Laguna Verde, the uplift rate differs more than three times northward

Critical care medicine as a distinct product line with substantial financial profitability: the role of business planning.

PubMed

Bekes, Carolyn E; Dellinger, R Phillip; Brooks, Daniel; Edmondson, Robert; Olivia, Christopher T; Parrillo, Joseph E

2004-05-01

As academic health centers face increasing financial pressures, they have adopted a more businesslike approach to planning, particularly for discrete "product" or clinical service lines. Since critical care typically has been viewed as a service provided by a hospital, and not a product line, business plans have not historically been developed to expand and promote critical care. The major focus when examining the finances of critical care has been cost reduction, not business development. We hypothesized that a critical care business plan can be developed and analyzed like other more typical product lines and that such a critical care product line can be profitable for an institution. In-depth analysis of critical care including business planning for critical care services. Regional academic health center in southern New Jersey. None. As part of an overall business planning process directed by the Board of Trustees, the critical care product line was identified by isolating revenue, expenses, and profitability associated with critical care patients. We were able to identify the major sources ("value chain") of critical care patients: the emergency room, patients who are admitted for other problems but spend time in a critical care unit, and patients transferred to our intensive care units from other hospitals. The greatest opportunity to expand the product line comes from increasing the referrals from other hospitals. A methodology was developed to identify the revenue and expenses associated with critical care, based on the analysis of past experience. With this model, we were able to demonstrate a positive contribution margin of dollar 7 million per year related to patients transferred to the institution primarily for critical care services. This can be seen as the profit related to the product line segment of critical care. There was an additional positive contribution margin of dollar 5.8 million attributed to the critical care portion of the hospital stay of

Towards real-time detection of tumor margins using photothermal imaging of immune-targeted gold nanoparticles

PubMed Central

Jakobsohn, Kobi; Motiei, Menachem; Sinvani, Moshe; Popovtzer, Rachela

2012-01-01

Background One of the critical problems in cancer management is local recurrence of disease. Between 20% and 30% of patients who undergo tumor resection surgery require reoperation due to incomplete excision. Currently, there are no validated methods for intraoperative tumor margin detection. In the present work, we demonstrate the potential use of gold nanoparticles (GNPs) as a novel contrast agent for photothermal molecular imaging of cancer. Methods Phantoms containing different concentrations of GNPs were irradiated with continuous-wave laser and measured with a thermal imaging camera which detected the temperature field of the irradiated phantoms. Results The results clearly demonstrate the ability to distinguish between cancerous cells specifically targeted with GNPs and normal cells. This technique, which allows highly sensitive discrimination between adjacent low GNP concentrations, will allow tumor margin detection while the temperature increases by only a few degrees Celsius (for GNPs in relevant biological concentrations). Conclusion We expect this real-time intraoperative imaging technique to assist surgeons in determining clear tumor margins and to maximize the extent of tumor resection while sparing normal background tissue. PMID:22956871

Microbial communities in methane seep sediments along US Atlantic Margin are structured by organic matter and seepage dynamics

NASA Astrophysics Data System (ADS)

Graw, M. F.; Pohlman, J.; Treude, T.; Ruppel, C. D.; Colwell, F. S.

2016-12-01

Methane seeps are dynamic environments on continental margins where subsurface methane reaches the ocean. Microbial communities play a critical role in carbon cycling within seep sediments via organic carbon degradation, methane production, and anaerobic oxidation of methane (AOM), which consumes 20-80% of methane in seep sediments. However, biogeochemical controls on microbial community structure at seeps on a margin-wide scale remain unclear. The passive US Atlantic Margin (USAM) has been identified as a region of active methane seepage. Passive margin seeps have traditionally been understudied relative to seeps on active margins. Passive margins exhibit large cross-margin variability in organic carbon deposition and are anticipated to have divergent seep dynamics from active margins. Thus, the USAM offers a unique opportunity to investigate controls on microbial communities in seep sediments. We undertook analysis of microbial communities inhabiting seep sediments at 6 biogeochemically distinct sites along the USAM. Microbiological samples were co-located with measurements of sediment geochemistry and AOM and sulfate reduction rates. Illumina sequencing of the 16S rRNA gene, using both universal (83 samples) and archaeal-specific (64 samples) primers, and the mcrA gene (18 samples) identified 44 bacterial phyla and 7 archaeal phyla. Seeps in canyons and on open slope, likely representing high and low organic content sediments, hosted distinct communities; the former was dominated by ammonia-oxidizing Marine Group I Thaumarchaeota and the latter by mixotrophic Hadesarchaeota. Seep stability also impacted microbial community structure, and in particular the establishment of an AOM community rather than a Bathyarchaeota-dominated community. These findings contribute to understanding how microbial communities are structured within methane seep sediments and pave the way for investigating broad differences in carbon cycling between seeps on passive and active margins.

Kinematic Reconstruction of the Costa Rican Margin: Evidence for Discontinuities in Deformation Across the Margin

NASA Astrophysics Data System (ADS)

Gose, B.; Bangs, N. L.; McIntosh, K. D.

2016-12-01

Recently acquired 3D seismic reflection data shows that both in-sequence and out-of sequence faults makeup the interior structure of the Costa Rican convergent margin. Recent studies have found evidence for a phase of accretion that led to the formation of a series of thrust-bounded folds that are easily observable within the margin-wedge fabric. Along a primary 2D transect through the center of the 3D survey, faults partition the outer 23km of the margin into 8 fault-bounded segments that can be divided into two characteristic zones, those closest to the trench (S1-S3) and those furthest (S4-S8) separated by a slope break 10 km from the trench (Fig 1). To better understand the observed structure, each segment was characterized as a fault-propagation fold and geometrically modeled using Paradigm's Geosec 2D software. Kinematic flexural slip modules were applied in order to perform bed-length balancing and generate a geologic reconstruction of the margin. Results show the section of the margin spanning from 3-23km from the deformation front has experienced 27.5% shortening, assuming the interpreted horizons were initially flat and continuous. The individual values for percent shortening are not consistent across the margin but distributed into two zones each with progressively increasing strain in the landward direction. Zone 2 (landward) begins with a percent shortening for S8 at 22% and linearly decreases to 2% shortening as you move seaward to S4. The Zone 1-2 boundary is marked by a slope break coinciding with an increase in percent shortening (S3,15%) followed by less shortening seaward (9%, 8%). Shortening and the associated strain is focused at the landward side of the two zones, within S3 and S8. We conclude that the Costa Rican margin has some degree of mechanical partitioning, with a notable discontinuity in strain patterns occurring 10 km from the trench.

17 CFR 242.405 - Withdrawal of margin.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 17 Commodity and Securities Exchanges 3 2010-04-01 2010-04-01 false Withdrawal of margin. 242.405 Section 242.405 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION (CONTINUED) REGULATIONS M, SHO, ATS, AC, AND NMS AND CUSTOMER MARGIN REQUIREMENTS FOR SECURITY FUTURES Customer Margin...

Becoming Critical: A Challenge for the Global Learning Programme?

ERIC Educational Resources Information Center

Huckle, John

2017-01-01

The Global Learning Programme (GLP) in England employs a new form of networked governance to deliver education for sustainable development in schools. This article focuses on Biccum's claim that such programmes serve to sustain the prevailing neo-liberal hegemony by further marginalizing critical voices such as those drawing on Marxist and…

Quantifying Water Stress Using Total Water Volumes and GRACE

NASA Astrophysics Data System (ADS)

Richey, A. S.; Famiglietti, J. S.; Druffel-Rodriguez, R.

2011-12-01

Water will follow oil as the next critical resource leading to unrest and uprisings globally. To better manage this threat, an improved understanding of the distribution of water stress is required today. This study builds upon previous efforts to characterize water stress by improving both the quantification of human water use and the definition of water availability. Current statistics on human water use are often outdated or inaccurately reported nationally, especially for groundwater. This study improves these estimates by defining human water use in two ways. First, we use NASA's Gravity Recovery and Climate Experiment (GRACE) to isolate the anthropogenic signal in water storage anomalies, which we equate to water use. Second, we quantify an ideal water demand by using average water requirements for the domestic, industrial, and agricultural water use sectors. Water availability has traditionally been limited to "renewable" water, which ignores large, stored water sources that humans use. We compare water stress estimates derived using either renewable water or the total volume of water globally. We use the best-available data to quantify total aquifer and surface water volumes, as compared to groundwater recharge and surface water runoff from land-surface models. The work presented here should provide a more realistic image of water stress by explicitly quantifying groundwater, defining water availability as total water supply, and using GRACE to more accurately quantify water use.

Transient Stability Output Margin Estimation Based on Energy Function Method

NASA Astrophysics Data System (ADS)

Miwa, Natsuki; Tanaka, Kazuyuki

In this paper, a new method of estimating critical generation margin (CGM) in power systems is proposed from the viewpoint of transient stability diagnostic. The proposed method has the capability to directly compute the stability limit output for a given contingency based on transient energy function method (TEF). Since CGM can be directly obtained by the limit output using estimated P-θ curves and is easy to understand, it is more useful rather than conventional critical clearing time (CCT) of energy function method. The proposed method can also estimate CGM as its negative value that means unstable in present load profile, then negative CGM can be directly utilized as generator output restriction. The proposed method is verified its accuracy and fast solution ability by applying to simple 3-machine model and IEEJ EAST10-machine standard model. Furthermore the useful application to severity ranking of transient stability for a lot of contingency cases is discussed by using CGM.

Evolution of Devonian carbonate-shelf margin, Nevada

USGS Publications Warehouse

Morrow, J.R.; Sandberg, C.A.

2008-01-01

The north-trending, 550-km-long Nevada segment of the Devonian carbonate-shelf margin, which fringed western North America, evidences the complex interaction of paleotectonics, eustasy, biotic changes, and bolide impact-related influences. Margin reconstruction is complicated by mid-Paleozoic to Paleogene compressional tectonics and younger extensional and strike-slip faulting. Reports published during the past three decades identify 12 important events that influenced development of shelf-margin settings; in chronological order, these are: (1) Early Devonian inheritance of Silurian stable shelf inargin, (2) formation of Early to early Middle 'Devonian shelf-margin basins, (3) propradation of later Middle Devonian shelf margin, (4) late Middle Devonian Taghanic ondap and continuing long-term Frasnian transgression, (5) initiation of latest Middle Devonian to early Frasnian proto-Antler orogenic forebulge, (6) mid-Frasnian Alamo Impact, (7) accelerated development of proto-Antler forebulge and backbulge Pilot basin, (8) global late Frasnian sentichatovae sea-level rise, (9) end-Frasnian sea-level fluctuations and ensuing mass extinction, (10) long-term Famennian regression and continept-wide erosion, (11) late Famennian emergence: of Ahtler orogenic highlands, and (12) end-Devonian eustatic sea-level fall. Although of considerable value for understanding facies relationships and geometries, existing standard carbonate platform-margin models developed for passive settings else-where do not adequately describe the diverse depositional and, structural settings along the Nevada Devonian platform margin. Recent structural and geochemical studies suggest that the Early to Middle Devonian-shelf-margin basins may have been fault-bound and controlled by inherited Precambrian structure. Subsequently, the migrating latest Middle to Late Devonian Antler orogenic forebulge exerted a dominant control on shelf-margin position, morphology, and sedimentation. ??Geological Society of

17 CFR 41.45 - Required margin.

Code of Federal Regulations, 2010 CFR

2010-04-01

...) Offsetting positions. Notwithstanding the margin levels specified in paragraph (b)(1) of this section, a self-regulatory authority may set the required initial or maintenance margin level for an offsetting position...

Marginal Iodine Deficiency Affects Dendritic Spine Development by Disturbing the Function of Rac1 Signaling Pathway on Cytoskeleton.

PubMed

Min, Hui; Dong, Jing; Wang, Yi; Wang, Yuan; Yu, Ye; Shan, Zhongyan; Xi, Qi; Teng, Weiping; Chen, Jie

2017-01-01

Iodine deficiency (ID)-induced thyroid hormone (TH) insufficient during development leads to impairments of brain function, such as learning and memory. Marginal ID has been defined as subtle insufficiency of TH, characterized as low thyroxine (T 4 ) levels, whether marginal ID potentially had adverse effects on the development of hippocampus and the underlying mechanisms remain unclear. Thus, in the present study, we established Wistar rat models with ID diet during pregnancy and lactation. The effects of marginal ID on long-term potentiation (LTP) were investigated in the hippocampal CA1 region. To study the development of dendritic spines in pyramidal cells, Golgi-Cox staining was conducted on postnatal day (PN) 7, PN14, PN21, and PN28. The activation of Rac1 signaling pathway, which is essential for dendritic spine development by regulating actin cytoskeleton, was also investigated. Our results showed that marginal ID slightly reduced the field-excitatory postsynaptic potential (f-EPSP) slope and the population spike (PS) amplitude. Besides, the density of dendritic spines during the critical period of rat postnatal development was mildly decreased, and we found no significant change of spine morphology in marginal ID group. We also observed decreased activation of the Rac1 signaling pathway in pups subjected to maternal marginal ID. Our study may support the hypothesis that decreased T 4 induced by marginal ID results in slight impairments of LTP and leads to mild damage of dendritic spine development, which may be due to abnormal regulation of Rac1 signaling pathway on cytoskeleton.

Critical Perspectives on the National Policy on Education 2016

ERIC Educational Resources Information Center

Bhattacharya, Somdatta; Deb, Swarupa; Nair, Hari; Shukla, Tanu; Yadav, Anupam

2017-01-01

This article brings together critical perspectives on a broad range of issues that emerge from a reading of the National Policy on Education 2016. The issues vary from accountability to transdisciplinarity and from the marginalization of transgender people to value education. Such a complex task of critiquing this policy document cannot be…

Researching Students with Disabilities: The Importance of Critical Perspectives

ERIC Educational Resources Information Center

Vaccaro, Annemarie; Kimball, Ezekiel W.; Wells, Ryan S.; Ostiguy, Benjamin J.

2014-01-01

In this chapter, the authors critically review the current state of quantitative research on college students with disabilities and examine the exclusion of this marginalized population from much of our research. They propose ways to conduct research that more fully accounts for this diverse and important college population. The authors argue that…

Getting critical with children: empowering approaches with a disempowered group.

PubMed

Berman, Helene

2003-01-01

The study of children and childhood has historically been accorded a marginal place in the health, human, and social sciences. In part, this is due to prevailing Western ideology that constructs children as passive, presocial, innocent, and vulnerable. The dominant discourse is further characterized by the treatment of children as a homogeneous group, devoid of race, class, or gender. While many investigators have described strategies for the conduct of research that is situated in the interpretive paradigm, there has been no comparable articulation of ideas regarding the conduct of critically grounded research when our participants are children. The purpose of this article is to put forth a historical and contextual analysis of childhood, including a discussion of evolving perspectives about childhood. The manner by which changing social, political, and environmental landscapes have contributed to the marginalization and disenfranchisement of children is examined. Finally, strategies for conducting nursing research that is grounded in the critical paradigmatic perspective, with the simultaneous aims of action, change, and empowerment, are proposed.

The Continental Margins Program in Georgia

USGS Publications Warehouse

Cocker, M.D.; Shapiro, E.A.

1999-01-01

From 1984 to 1993, the Georgia Geologic Survey (GGS) participated in the Minerals Management Service-funded Continental Margins Program. Geological and geophysical data acquisition focused on offshore stratigraphic framework studies, phosphate-bearing Miocene-age strata, distribution of heavy minerals, near-surface alternative sources of groundwater, and development of a PC-based Coastal Geographic Information System (GIS). Seven GGS publications document results of those investigations. In addition to those publications, direct benefits of the GGS's participation include an impetus to the GGS's investigations of economic minerals on the Georgia coast, establishment of a GIS that includes computer hardware and software, and seeds for additional investigations through the information and training acquired as a result of the Continental Margins Program. These addtional investigations are quite varied in scope, and many were made possible because of GIS expertise gained as a result of the Continental Margins Program. Future investigations will also reap the benefits of the Continental Margins Program.From 1984 to 1993, the Georgia Geologic Survey (GGS) participated in the Minerals Management Service-funded Continental Margins Program. Geological and geophysical data acquisition focused on offshore stratigraphic framework studies, phosphate-bearing Miocene-age strata, distribution of heavy minerals, near-surface alternative sources of groundwater, and development of a PC-based Coastal Geographic Information System (GIS). Seven GGS publications document results of those investigations. In addition to those publications, direct benefits of the GGS's participation include an impetus to the GGS's investigations of economic minerals on the Georgia coast, establishment of a GIS that includes computer hardware and software, and seeds for additional investigations through the information and training acquired as a result of the Continental Margins Program. These additional

Formation and evolution of magma-poor margins, an example of the West Iberia margin

NASA Astrophysics Data System (ADS)

Perez-Gussinye, Marta; Andres-Martinez, Miguel; Morgan, Jason P.; Ranero, Cesar R.; Reston, Tim

2016-04-01

The West Iberia-Newfoundland (WIM-NF) conjugate margins have been geophysically and geologically surveyed for the last 30 years and have arguably become a paradigm for magma-poor extensional margins. Here we present a coherent picture of the WIM-NF rift to drift evolution that emerges from these observations and numerical modeling, and point out important differences that may exist with other magma-poor margins world-wide. The WIM-NF is characterized by a continental crust that thins asymmetrically and a wide and symmetric continent-ocean transition (COT) interpreted to consist of exhumed and serpentinised mantle with magmatic products increasing oceanward. The architectural evolution of these margins is mainly dominated by cooling under very slow extension velocities (<~6 mm/yr half-rate) and a lower crust that most probably was not extremely weak at the start of rifting. These conditions lead to a system where initially deformation is distributed over a broad area and the upper, lower crust and lithosphere are decoupled. As extension progresses upper, lower, crust and mantle become tightly coupled and deformation localizes due to strengthening and cooling during rifting. Coupling leads to asymmetric asthenospheric uplift and weakening of the hanginwall of the active fault, where a new fault forms. This continued process leads to the formation of an array of sequential faults that dip and become younger oceanward. Here we show that these processes acting in concert: 1) reproduce the margin asymmetry observed at the WIM-NF, 2) explain the fault geometry evolution from planar, to listric to detachment like by having one common Andersonian framework, 3) lead to the symmetric exhumation of mantle with little magmatism, and 4) explain the younging of the syn-rift towards the basin centre and imply that unconformities separating syn- and post-rift may be diachronous and younger towards the ocean. Finally, we show that different lower crustal rheologies lead to different

Towards intraoperative assessment of tumor margins in breast surgery using optical coherence elastography (Conference Presentation)

NASA Astrophysics Data System (ADS)

Kennedy, Brendan F.; Wijesinghe, Philip; Allen, Wes M.; Chin, Lixin; Latham, Bruce; Saunders, Christobel M.; Sampson, David D.

2016-03-01

Surgical excision of tumor is a critical factor in the management of breast cancer. The most common surgical procedure is breast-conserving surgery. The surgeon's goal is to remove the tumor and a rim of healthy tissue surrounding the tumor: the surgical margin. A major issue in breast-conserving surgery is the absence of a reliable tool to guide the surgeon in intraoperatively assessing the margin. A number of techniques have been proposed; however, the re-excision rate remains high and has been reported to be in the range 30-60%. New tools are needed to address this issue. Optical coherence elastography (OCE) shows promise as a tool for intraoperative tumor margin assessment in breast-conserving surgery. Further advances towards clinical translation are limited by long scan times and small fields of view. In particular, scanning over sufficient areas to assess the entire margin in an intraoperative timeframe has not been shown to be feasible. Here, we present a protocol allowing ~75% of the surgical margins to be assessed within 30 minutes. To achieve this, we have incorporated a 65 mm-diameter (internal), wide-aperture annular piezoelectric transducer, allowing the entire surface of the excised tumor mass to be automatically imaged in an OCT mosaic comprised of 10 × 10 mm tiles. As OCT is effective in identifying adipose tissue, our protocol uses the wide-field OCT to selectively guide subsequent local OCE scanning to regions of solid tissue which often present low contrast in OCT images. We present promising examples from freshly excised human breast tissue.

Partitioning of deformation along a reactivated rifted margin: example of the northern Ligurian margin.

NASA Astrophysics Data System (ADS)

Sage, Françoise; Beslier, Marie-Odile; Gaullier, Virginie; Larroque, Christophe; Dessa, Jean-Xavier; Mercier de Lepinay, Bernard; Corradi, Nicola; Migeon, Sébastien; Katz, Hélène; Ruiz Constan, Ana

2013-04-01

The northern Ligurian margin, of Oligo-Miocene age, is currently undergoing compression related to microplate motions and/or to gravity spreading of the Alpine chain located immediately north of it. Active thrust faults and folds have previously been identified below the margin, together with a global uplift of the continental edge, since at least the Messinian. The seismicity that goes with the present-day margin contraction (e.g. Mw 6.9, 1887/02/23) extends to the axis of the adjacent oceanic basin (e.g. ML 6.0, 1963/07/19; ML 5.4, 2011/07/07). However, we do not know of any recent or active crustal contractional structure within this oceanic domain. In this study, we use new 12-channel high-resolution seismic data (FABLES seismic cruise, 2012, R/V Tethys II) in order to image the sedimentary cover of the Ligurian oceanic basin, up to ~3km below the seabed, including the Plio-Quaternary and the Messinian sediment down to the bottom of the Messinian salt layer. Because the Messinian event is well dated (5.96-5.32 Ma) and well identified in the seismic data, it forms a clear marker that we use to characterize the recent deformation related to both mobile salt motion and crustal tectonics. About 50 km south of the margin offshore of Italy, we identify huge and complex salt walls that elongate SW-NE. Such salt walls, which cannot be explained by salt tectonics only, are interpreted as evidence of deep-seated crustal deformation. They form en echelon structures that are well expressed in the seabed morphology, and do not correspond to any significant vertical throw at the base of the salt layer. This suggests that within the deep basin, mainly strike-slip faulting accommodates long-term crustal deformation. It thus offers a contrast with the margin where deformation is mainly marked by shortening and reverse faulting, with vertical throws of several hundred meters. This discrepancy in the tectonic styles between the margin and the adjacent oceanic basin suggests some

Quantifiers more or less quantify online: ERP evidence for partial incremental interpretation

PubMed Central

Urbach, Thomas P.; Kutas, Marta

2010-01-01

Event-related brain potentials were recorded during RSVP reading to test the hypothesis that quantifier expressions are incrementally interpreted fully and immediately. In sentences tapping general knowledge (Farmers grow crops/worms as their primary source of income), Experiment 1 found larger N400s for atypical (worms) than typical objects (crops). Experiment 2 crossed object typicality with non-logical subject-noun phrase quantifiers (most, few). Off-line plausibility ratings exhibited the crossover interaction predicted by full quantifier interpretation: Most farmers grow crops and Few farmers grow worms were rated more plausible than Most farmers grow worms and Few farmers grow crops. Object N400s, although modulated in the expected direction, did not reverse. Experiment 3 replicated these findings with adverbial quantifiers (Farmers often/rarely grow crops/worms). Interpretation of quantifier expressions thus is neither fully immediate nor fully delayed. Furthermore, object atypicality was associated with a frontal slow positivity in few-type/rarely quantifier contexts, suggesting systematic processing differences among quantifier types. PMID:20640044

Sinking Jelly-Carbon Unveils Potential Environmental Variability along a Continental Margin

PubMed Central

Lebrato, Mario; Molinero, Juan-Carlos; Cartes, Joan E.; Lloris, Domingo; Mélin, Frédéric; Beni-Casadella, Laia

2013-01-01

Particulate matter export fuels benthic ecosystems in continental margins and the deep sea, removing carbon from the upper ocean. Gelatinous zooplankton biomass provides a fast carbon vector that has been poorly studied. Observational data of a large-scale benthic trawling survey from 1994 to 2005 provided a unique opportunity to quantify jelly-carbon along an entire continental margin in the Mediterranean Sea and to assess potential links with biological and physical variables. Biomass depositions were sampled in shelves, slopes and canyons with peaks above 1000 carcasses per trawl, translating to standing stock values between 0.3 and 1.4 mg C m2 after trawling and integrating between 30,000 and 175,000 m2 of seabed. The benthopelagic jelly-carbon spatial distribution from the shelf to the canyons may be explained by atmospheric forcing related with NAO events and dense shelf water cascading, which are both known from the open Mediterranean. Over the decadal scale, we show that the jelly-carbon depositions temporal variability paralleled hydroclimate modifications, and that the enhanced jelly-carbon deposits are connected to a temperature-driven system where chlorophyll plays a minor role. Our results highlight the importance of gelatinous groups as indicators of large-scale ecosystem change, where jelly-carbon depositions play an important role in carbon and energy transport to benthic systems. PMID:24367499

A quantitative analysis of transtensional margin width

NASA Astrophysics Data System (ADS)

Jeanniot, Ludovic; Buiter, Susanne J. H.

2018-06-01

Continental rifted margins show variations between a few hundred to almost a thousand kilometres in their conjugated widths from the relatively undisturbed continent to the oceanic crust. Analogue and numerical modelling results suggest that the conjugated width of rifted margins may have a relationship to their obliquity of divergence, with narrower margins occurring for higher obliquity. We here test this prediction by analysing the obliquity and rift width for 26 segments of transtensional conjugate rifted margins in the Atlantic and Indian Oceans. We use the plate reconstruction software GPlates (http://www.gplates.org) for different plate rotation models to estimate the direction and magnitude of rifting from the initial phases of continental rifting until breakup. Our rift width corresponds to the distance between the onshore maximum topography and the last identified continental crust. We find a weak positive correlation between the obliquity of rifting and rift width. Highly oblique margins are narrower than orthogonal margins, as expected from analogue and numerical models. We find no relationships between rift obliquities and rift duration nor the presence or absence of Large Igneous Provinces (LIPs).

Methods of defining the non-inferiority margin in randomized, double-blind controlled trials: a systematic review.

PubMed

Althunian, Turki A; de Boer, Anthonius; Klungel, Olaf H; Insani, Widya N; Groenwold, Rolf H H

2017-03-07

There is no consensus on the preferred method for defining the non-inferiority margin in non-inferiority trials, and previous studies showed that the rationale for its choice is often not reported. This study investigated how the non-inferiority margin is defined in the published literature, and whether its reporting has changed over time. A systematic PubMed search was conducted for all published randomized, double-blind, non-inferiority trials from January 1, 1966, to February 6, 2015. The primary outcome was the number of margins that were defined by methods other than the historical evidence of the active comparator. This was evaluated for a time trend. We also assessed the under-reporting of the methods of defining the margin as a secondary outcome, and whether this changed over time. Both outcomes were analyzed using a Poisson log-linear model. Predictors for better reporting of the methods, and the use of the fixed-margin method (one of the historical evidence methods) were also analyzed using logistic regression. Two hundred seventy-three articles were included, which account for 273 non-inferiority margins. There was no statistically significant difference in the number of margins that were defined by other methods compared to those defined based on the historical evidence (ratio 2.17, 95% CI 0.86 to 5.82, p = 0.11), and this did not change over time. The number of margins for which methods were unreported was similar to those with reported methods (ratio 1.35, 95% CI 0.76 to 2.43, p = 0.31), with no change over time. The method of defining the margin was less often reported in journals with low-impact factors compared to journals with high-impact factors (OR 0.20; 95% CI 0.10 to 0.37, p < 0.0001). The publication of the FDA draft guidance in 2010 was associated with increased reporting of the fixed-margin method (after versus before 2010) (OR 3.54; 95% CI 1.12 to 13.35, p = 0.04). Non-inferiority margins are not commonly defined based on

Modelling the role of magmatic intrusions in the post-breakup thermal evolution of Volcanic Passive Margins

NASA Astrophysics Data System (ADS)

Peace, Alexander; McCaffrey, Ken; Imber, Jonny; van Hunen, Jeroen; Hobbs, Richard; Gerdes, Keith

2013-04-01

increases, and the effects of even a large singular magmatic event are small beyond the immediate vicinity, therefore quantifying cumulative regional heat flow is of utmost importance. The apparently complex relationships between source rock maturation and magmatism are not limited to the north-east Atlantic margins. Other VPMs of interest include the regions between West Greenland and Eastern Canada (Labrador Sea, Davis Strait and Baffin Bay), East Greenland, NW Australia, Western India and segments of the Western African and Eastern South American margins. This project utilises 1D numerical modelling of magmatic intrusions into a sedimentary column to gain an understanding into the thermal influence of post-breakup magmatic activity on source rock maturation in representative VPMs. Considerations include the timing, periodicity of intrusions, thickness, spacing and background heat in the basin.

Marginality principle

USDA-ARS?s Scientific Manuscript database

Soil is a fragile resource supplying many goods and services. Given the diversity of soil across the world and within a landscape, there are many different capacities among soils to provide the basic soil functions. Marginality of soils is a difficult process to define because the metrics to define ...

[Resection margins in conservative breast cancer surgery].

PubMed

Medina Fernández, Francisco Javier; Ayllón Terán, María Dolores; Lombardo Galera, María Sagrario; Rioja Torres, Pilar; Bascuñana Estudillo, Guillermo; Rufián Peña, Sebastián

2013-01-01

Conservative breast cancer surgery is facing a new problem: the potential tumour involvement of resection margins. This eventuality has been closely and negatively associated with disease-free survival. Various factors may influence the likelihood of margins being affected, mostly related to the characteristics of the tumour, patient or surgical technique. In the last decade, many studies have attempted to find predictive factors for margin involvement. However, it is currently the new techniques used in the study of margins and tumour localisation that are significantly reducing reoperations in conservative breast cancer surgery. Copyright © 2012 AEC. Published by Elsevier Espana. All rights reserved.

Exact renormalization group equation for the Lifshitz critical point

NASA Astrophysics Data System (ADS)

Bervillier, C.

2004-10-01

An exact renormalization equation (ERGE) accounting for an anisotropic scaling is derived. The critical and tricritical Lifshitz points are then studied at leading order of the derivative expansion which is shown to involve two differential equations. The resulting estimates of the Lifshitz critical exponents compare well with the O(ε) calculations. In the case of the Lifshitz tricritical point, it is shown that a marginally relevant coupling defies the perturbative approach since it actually makes the fixed point referred to in the previous perturbative calculations O(ε) finally unstable.

Methylation patterns in marginal zone lymphoma.

PubMed

Arribas, Alberto J; Bertoni, Francesco

Promoter DNA methylation is a major regulator of gene expression and transcription. The identification of methylation changes is important for understanding disease pathogenesis, for identifying prognostic markers and can drive novel therapeutic approaches. In this review we summarize the current knowledge regarding DNA methylation in MALT lymphoma, splenic marginal zone lymphoma, nodal marginal zone lymphoma. Despite important differences in the study design for different publications and the existence of a sole large and genome-wide methylation study for splenic marginal zone lymphoma, it is clear that DNA methylation plays an important role in marginal zone lymphomas, in which it contributes to the inactivation of tumor suppressors but also to the expression of genes sustaining tumor cell survival and proliferation. Existing preclinical data provide the rationale to target the methylation machinery in these disorders. Copyright © 2016 Elsevier Ltd. All rights reserved.

Silenced, Silence, Silent: Motherhood in the Margins

ERIC Educational Resources Information Center

Carpenter, Lorelei; Austin, Helena

2007-01-01

This project explores the experiences of women who mother children with ADHD. The authors use the metaphor of the text and the margin. The text is the "motherhood myth" that describes a particular sort of "good" mothering. The margin is the space beyond that text. This marginal space is inhabited by some or all of the mothers they spoke with, some…

Geomorphology of the Eastern North American Continental Margin: the role of deep sea sedimentation processes

NASA Astrophysics Data System (ADS)

Mosher, D. C.; Campbell, C.; Piper, D.; Chaytor, J. D.; Gardner, J. V.; Rebesco, M.

2016-12-01

Deep-sea sedimentation processes impart a fundamental control on the morphology of the western North Atlantic continental margin from Blake Spur to Hudson Strait. This fact is illustrated by the variable patterns of cross-margin gradients that are based on extensive new multibeam echo-sounder data in concert with subbottom profiler and seismic reflection data. Most of the continental margin has a steep (>3o) upper slope down to 1500 to 2500 m and then a gradual middle and lower slope with a general concave upward shape There is a constant interplay of deep sea sedimentation processes, but the general morphology is dictated by the dominant one. Erosion by off-shelf sediment transport in turbidity currents creating channels, gullies and canyons creates the steep upper slope. These gullies and canyons amalgamate to form singular channels that are conduits to the abyssal plain. This process results in a general seaward flattening of gradients, producing an exponentially decaying slope profile. Comparatively, sediment mass failure produces steeper upper slopes due to head scarp development and a wedging architecture to the lower slope as deposits thin in the downslope direction. This process results in either a two-segment slope, and/or a significant downslope gradient change where MTDs pinch out. Large sediment bodies deposited by contour-following currents are developed all along the margin. Blake Ridge, Sackville Spur, and Hamilton Spur are large detached drifts on disparate parts of the margin. Along their crests, they form a linear profile from the shelf to abyssal plain. Deeper portions of the US continental margin are dominated by the Chesapeake Drift and Hatteras Outer Ridge; both plastered elongate mounded drifts. Farther north, particularly on the Grand Banks margin, are plastered and separated drifts. These drifts tend to form bathymetric steps in profile, where they onlap the margin. Stacked drifts create several steps. Turbidites of the abyssal plain onlap

Continental transform margins : state of art and future milestones

NASA Astrophysics Data System (ADS)

Basile, Christophe

2010-05-01

Transform faults were defined 45 years ago as ‘a new class of fault' (Wilson, 1965), and transform margins were consequently individualized as a new class of continental margins. While transform margins represent 20 to 25 % of the total length of continent-ocean transitions, they were poorly studied, especially when compared with the amount of data, interpretations, models and conceptual progress accumulated on divergent or convergent continental margins. The best studied examples of transform margins are located in the northern part of Norway, south of South Africa, in the gulf of California and on both sides of the Equatorial Atlantic. Here is located the Côte d'Ivoire - Ghana margin, where the more complete data set was acquired, based on numerous geological and geophysical cruises, including ODP Leg 159. The first models that encompassed the structure and evolution of transform margins were mainly driven by plate kinematic reconstructions, and evidenced the diachronic end of tectonic activity and the non-cylindrical character of these margins, with a decreasing strike-slip deformation from the convex to the concave divergent-transform intersections. Further thermo-mechanical models were more specifically designed to explain the vertical displacements along transform margins, and especially the occurrence of high-standing marginal ridges. These thermo-mechanical models involved either heat transfer from oceanic to continental lithospheres across the transform faults or tectonically- or gravity-driven mass transfer in the upper crust. These models were far from fully fit observations, and were frequently dedicated to specific example, and not easily generalizable. Future work on transform continental margins may be expected to fill some scientific gaps, and the definition of working directions can benefit from the studies dedicated to other types of margins. At regional scale the structural and sedimentological variability of transform continental margins has

Dismantling the Silence: LGBTQ Aging Emerging From the Margins.

PubMed

Fredriksen-Goldsen, Karen I

2017-02-01

Historical, environmental, and cultural contexts intersect with aging, sexuality, and gender across communities and generations. My scholarship investigates health and well-being over the life course across marginalized communities, including LGBTQ (lesbian, gay, bisexual, transgender, and queer) midlife and older adults, native communities experiencing cardiovascular risk, and families in China living with HIV, in order to balance the realities of unique lives in contemporary society. By probing the intersection of age, sexuality, and gender, my analysis is informed by both personal and professional experiences. With the death of my partner occurring at a time of profound invisibility and silence before HIV/AIDS, I found my life out of sync, experiencing a loss without a name. My life was thrust into a paradox: My relationship was defined by a world that refused to recognize it. This essay provides an opportunity for me to weave together how such critical turning points in my own life helped shape my approach to gerontology and how gerontology has informed my work and life. Reflecting on this journey, I illustrate the ways in which historical, structural, environmental, psychosocial, and biological factors affect equity, and the health-promoting and adverse pathways to health and well-being across marginalized communities. Although gerontology as a discipline has historically silenced the lives of marginalized older adults, it has much to learn from these communities. The growing and increasingly diverse older adult population provides us with unique opportunities to better understand both cultural variations and shared experiences in aging over the life course. © The Author 2017. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

Quantifying phalangeal curvature: an empirical comparison of alternative methods.

PubMed

Stern, J T; Jungers, W L; Susman, R L

1995-05-01

It has been generally assumed and theoretically argued that the curvature of finger and toe bones seen in some nonhuman primates is associated with cheiridial use in an arboreal setting. Assessment of such curvature in fossil primates has been used to infer the positional behavior of these animals. Several methods of quantifying curvature of bones have been proposed. The measure most commonly applied to phalanges is that of included angle, but this has come under some criticism. We consider various other approaches for quantifying phalangeal curvature, demonstrating that some are equivalent to use of included angle, but that one--normalized curvature moment arm (NCMA)--represents a true alternative. A comparison of NCMA to included angle, both calculated on manual and pedal proximal phalanges of humans, apes, some monkeys, and the Hadar fossils, revealed that these two different measures of curvature are highly correlated and result in very similar distributional patterns.

Quantifying Anthropogenic Dust Emissions

NASA Astrophysics Data System (ADS)

Webb, Nicholas P.; Pierre, Caroline

2018-02-01

Anthropogenic land use and land cover change, including local environmental disturbances, moderate rates of wind-driven soil erosion and dust emission. These human-dust cycle interactions impact ecosystems and agricultural production, air quality, human health, biogeochemical cycles, and climate. While the impacts of land use activities and land management on aeolian processes can be profound, the interactions are often complex and assessments of anthropogenic dust loads at all scales remain highly uncertain. Here, we critically review the drivers of anthropogenic dust emission and current evaluation approaches. We then identify and describe opportunities to: (1) develop new conceptual frameworks and interdisciplinary approaches that draw on ecological state-and-transition models to improve the accuracy and relevance of assessments of anthropogenic dust emissions; (2) improve model fidelity and capacity for change detection to quantify anthropogenic impacts on aeolian processes; and (3) enhance field research and monitoring networks to support dust model applications to evaluate the impacts of disturbance processes on local to global-scale wind erosion and dust emissions.

Systematic Review of Studies Reporting Positive Surgical Margins After Bladder Neck Sparing Radical Prostatectomy.

PubMed

Bellangino, Mariangela; Verrill, Clare; Leslie, Tom; Bell, Richard W; Hamdy, Freddie C; Lamb, Alastair D

2017-11-07

Bladder neck preservation (BNP) during radical prostatectomy (RP) has been proposed as a method to improve early recovery of urinary continence after radical prostatectomy. However, there is concern over a possible increase in the risk of positive surgical margins and prostate cancer recurrence rate. A recent systematic review and meta-analysis reported improved early recovery and overall long-term urinary continence without compromising oncologic control. The aim of our study was to perform a critical review of the literature to assess the impact on bladder neck and base margins after bladder neck sparing radical prostatectomy. We carried out a systematic review of the literature using Pubmed, Scopus and Cochrane library databases in May 2017 using medical subject headings and free-text protocol according to PRISMA guidelines. We used the following search terms: bladder neck preservation, prostate cancer, radical prostatectomy and surgical margins. Studies focusing on positive surgical margins (PSM) in bladder neck sparing RP pertinent to the objective of this review were included. Overall, we found 15 relevant studies reporting overall and site-specific positive surgical margins rate after bladder neck sparing radical prostatectomy. This included two RCTs, seven prospective comparative studies, two retrospective comparative studies and four case series. All studies were published between 1993 and 2015 with sample sizes ranging between 50 and 1067. Surgical approaches included open, laparoscopic and robot-assisted radical prostatectomy. The overall and base-specific PSM rates ranged between 7-36% and 0-16.3%, respectively. Mean base PSM was 4.9% in those patients where bladder neck sparing was performed, but only 1.85% in those without sparing. Bladder neck preservation during radical prostatectomy may increase base-positive margins. Further studies are needed to better investigate the impact of this technique on oncological outcomes. A future paradigm could

US refining margin trend: austerity continues

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

Should crude oil prices hold near current levels in 1988, US refining margins might improve little, if at all. If crude oil prices rise, margins could blush pink or worse. If they drop, US refiners would still probably not see much margin improvement. In fact, if crude prices fall, they could set off another free fall in products markets and threaten refiner survival. Volatility in refined products markets and low product demand growth are the underlying reasons for caution or pessimism as the new year approaches. Recent directional patterns in refining margins are scrutinized in this issue. This issue alsomore » contains the following: (1) the ED refining netback data for the US Gulf and West Coasts, Rotterdam, and Singapore for late November, 1987; and (2) the ED fuel price/tax series for countries of the Eastern Hemisphere, November, 1987 edition. 4 figures, 6 tables.« less

Critical Zone Architecture and the Last Glacial Legacy in Unglaciated North America

NASA Astrophysics Data System (ADS)

Marshall, J. A.; Roering, J. J.; Rempel, A. W.; Bartlein, P. J.; Merritts, D. J.; Walter, R. C.

2015-12-01

As fresh bedrock is exhumed into the Critical Zone and intersects with water and life, rock attributes controlling geochemical reactions, hydrologic routing, accommodation space for roots, surface area, and the mobile fraction of regolith are set not just by present-day processes, but are predicated on the 'ghosts' of past processes embedded in the subsurface architecture. Easily observable modern ecosystem processes such as tree throw can erase the past and bias our interpretation of landscape evolution. Abundant paleoenvironmental records demonstrate that unglaciated regions experienced profound climate changes through the late Pleistocene-Holocene transition, but studies quantifying how environmental variables affect erosion and weathering rates in these settings often marginalize or even forego consideration of the role of past climate regimes. Here we combine seven downscaled Last Glacial Maximum (LGM) paleoclimate reconstructions with a state of the art frost cracking model to explore frost weathering potential across the North American continent 21 ka. We analyze existing evidence of LGM periglacial processes and features to better constrain frost weathering model predictions. All seven models predict frost cracking across a large swath to the west of the Continental Divide, with the southernmost extent at ~ latitude 35° N, and increasing latitude towards the buffering influence of the Pacific Ocean. All models predict significant frost cracking in the unglaciated Rocky Mountains. To the east of the Continental Divide, models results diverge more, but all predict regions with LGM temperatures too cold for significant frost cracking (mean annual temperatures < 15 °C), corroborated by observations of permafrost relics such as ice wedges in some areas. Our results provide a framework for coupling paleoclimate reconstructions with a predictive frost weathering model, and importantly, suggest that modeling modern Critical Zone process evolution may require a

The Macro Dynamics of Weapon System Acquisition: Shaping Early Decisions to Get Better Outcomes

DTIC Science & Technology

2012-05-17

defects and rework •Design tools and processes •Lack of feedback to key design and SE processes •Lack of quantified risk and uncertainty at key... Tools for Rapid Exploration of the Physical Design Space Coupling Operability, Interoperability, and Physical Feasibility Analyses – a Game Changer...Interoperability •Training Quantified Margins and Uncertainties at Each Critical Decision Point M&S RDT&E A Continuum of Tools Underpinned with

Critical Civic Literacy: Knowledge at the Intersection of Career and Community

ERIC Educational Resources Information Center

Pollack, Seth S.

2013-01-01

Traditional approaches to civic engagement have been marginalized and have had little impact on the core curriculum. "Critical civic literacy" is an alternative curricular approach to civic engagement that explicitly moves departments, disciplines, and degree programs to examine issues of social responsibility and social justice from the…

Critical Incident Effects on Principals: Using School Closure as the Context

ERIC Educational Resources Information Center

Lenarduzzi, Grant P.

2015-01-01

The effect of critical incidents on school principals has been marginally investigated. Principal leadership has many pleasures, but it is often replete with problematic circumstances. The skilled school-based leader requires rationality and diplomacy to manage conflict successfully. This study examined the perceived effects of a critical…

Evolved dispersal strategies at range margins

PubMed Central

Dytham, Calvin

2009-01-01

Dispersal is a key component of a species's ecology and will be under different selection pressures in different parts of the range. For example, a long-distance dispersal strategy suitable for continuous habitat at the range core might not be favoured at the margin, where the habitat is sparse. Using a spatially explicit, individual-based, evolutionary simulation model, the dispersal strategies of an organism that has only one dispersal event in its lifetime, such as a plant or sessile animal, are considered. Within the model, removing habitat, increasing habitat turnover, increasing the cost of dispersal, reducing habitat quality or altering vital rates imposes range limits. In most cases, there is a clear change in the dispersal strategies across the range, although increasing death rate towards the margin has little impact on evolved dispersal strategy across the range. Habitat turnover, reduced birth rate and reduced habitat quality all increase evolved dispersal distances at the margin, while increased cost of dispersal and reduced habitat density lead to lower evolved dispersal distances at the margins. As climate change shifts suitable habitat poleward, species ranges will also start to shift, and it will be the dispersal capabilities of marginal populations, rather than core populations, that will influence the rate of range shifting. PMID:19324810

Trichomonas vaginalis infection and associated risk factors in a socially-marginalized female population in coastal Peru.

PubMed

Leon, Segundo R; Konda, Kelika A; Bernstein, Kyle T; Pajuelo, Jose B; Rosasco, Ana M; Caceres, Carlos F; Coates, Thomas J; Klausner, Jeffrey D

2009-01-01

The epidemiology of Trichomonas vaginalis infection among sexually active socially-marginalized women in three urban, coastal Peruvian cities was examined in order to quantify the prevalence of trichomonas infection and identify associated risk factors. We conducted a cross-sectional, venue-based study of women from socially-marginalized populations in three coastal Peruvian cities. Among the 319 women enrolled, the overall prevalence of trichomonal infection was 9.1% (95% CI, 5.9%-12.3%). The mean age was 26.3 years, and 35.5% reported having had unprotected intercourse with nonprimary partners and 19.8% reported two or more sex partners in the last three months. Trichomonal infection was associated with increased number of sex partners (PR 2.5, 95% CI 1.4-4.6) and unprotected sex with nonprimary partner in the last three months (PR 2.3, 95% CI 1.1-4.9). A moderately high prevalence of trichomonal infection was found among women in our study. Trichomonal infection was associated with unprotected sex and multiple sex partners. Efforts to control the continued spread of trichomonal infection are warranted.

(De)colonizing culture in community psychology: reflections from critical social science.

PubMed

Reyes Cruz, Mariolga; Sonn, Christopher C

2011-03-01

Since its inception, community psychology has been interested in cultural matters relating to issues of diversity and marginalization. However, the field has tended to understand culture as static social markers or as the background for understanding group differences. In this article the authors contend that culture is inseparable from who we are and what we do as social beings. Moreover, culture is continually shaped by socio-historical and political processes intertwined within the globalized history of power. The authors propose a decolonizing standpoint grounded in critical social science to disrupt understandings of cultural matters that marginalize others. This standpoint would move the field toward deeper critical thinking, reflexivity and emancipatory action. The authors present their work to illustrate how they integrate a decolonizing standpoint to community psychology research and teaching. They conclude that community psychology must aim towards intercultural work engaging its political nature from a place of ontological/epistemological/methodological parity.

Deep-sea Lebensspuren of the Australian continental margins

NASA Astrophysics Data System (ADS)

Przeslawski, Rachel; Dundas, Kate; Radke, Lynda; Anderson, Tara J.

Much of the deep sea comprises soft-sediment habitats dominated by comparatively low abundances of species-rich macrofauna and meiofauna. Although often not observed, these animals bioturbate the sediment during feeding and burrowing, leaving signs of their activities called Lebensspuren ('life traces'). In this study, we use still images to quantify Lebensspuren from the eastern (1921 images, 13 stations, 1300-2200 m depth) and western (1008 images, 11 stations, 1500-4400 m depth) Australian margins using a univariate measure of trace richness and a multivariate measure of Lebensspuren assemblages. A total of 46 Lebensspuren types were identified, including those matching named trace fossils and modern Lebensspuren found elsewhere in the world. Most traces could be associated with waste, crawling, dwellings, organism tests, feeding, or resting, but the origin of 15% of trace types remains unknown. Assemblages were significantly different between the two regions and depth profiles, with five Lebensspuren types accounting for over 95% of the differentiation (ovoid pinnate trace, crater row, spider trace, matchstick trace, mesh trace). Lebensspuren richness showed no strong relationships with depth, total organic carbon, or mud, although there was a positive correlation to chlorin index (i.e., organic freshness) in the eastern margin, with richness increasing with organic freshness. Lebensspuren richness was not related to epifauna either, indicating that epifauna may not be the primary source of Lebensspuren. Despite the abundance and distinctiveness of several traces both in the current and previous studies (e.g., ovoid pinnate, mesh, spider), their origin and distribution remains a mystery. We discuss this and several other considerations in the identification and quantification of Lebensspuren. This study represents the first comprehensive catalogue of deep-sea Lebensspuren in Australian waters and highlights the potential of Lebensspuren as valuable and often

Mental Depreciation and Marginal Decision Making

PubMed

Heath; Fennema

1996-11-01

We propose that individuals practice "mental depreciation," that is, they implicitly spread the fixed costs of their expenses over time or use. Two studies explore how people spread fixed costs on durable goods. A third study shows that depreciation can lead to two distinct errors in marginal decisions: First, people sometimes invest too much effort to get their money's worth from an expense (e.g., they may use a product a lot to spread the fixed expense across more uses). Second, people sometimes invest too little effort to get their money's worth: When people add a portion of the fixed cost to the current costs, their perceived marginal (i.e., incremental) costs exceed their true marginal costs. In response, they may stop investing because their perceived costs surpass the marginal benefits they are receiving. The latter effect is supported by two field studies that explore real board plan decisions by university students.

Negative Stress Margins - Are They Real?

NASA Technical Reports Server (NTRS)

Raju, Ivatury S.; Lee, Darlene S.; Mohaghegh, Michael

2011-01-01

Advances in modeling and simulation, new finite element software, modeling engines and powerful computers are providing opportunities to interrogate designs in a very different manner and in a more detailed approach than ever before. Margins of safety are also often evaluated using local stresses for various design concepts and design parameters quickly once analysis models are defined and developed. This paper suggests that not all the negative margins of safety evaluated are real. The structural areas where negative margins are frequently encountered are often near stress concentrations, point loads and load discontinuities, near locations of stress singularities, in areas having large gradients but with insufficient mesh density, in areas with modeling issues and modeling errors, and in areas with connections and interfaces, in two-dimensional (2D) and three-dimensional (3D) transitions, bolts and bolt modeling, and boundary conditions. Now, more than ever, structural analysts need to examine and interrogate their analysis results and perform basic sanity checks to determine if these negative margins are real.

The Acoustic Signature of Glaciated Margins

NASA Astrophysics Data System (ADS)

Newton, A. M. W.; Huuse, M.

2016-12-01

As climate warms it has become increasingly clear that, in order to fully understand how it might evolve in the future, we need to look for examples of how climate has changed in the past. The Late Cenozoic history of the Arctic Ocean and its surrounding seas has been dominated by glacial-interglacials cycles. This has resulted in major environmental changes in relative sea levels, ice volumes, sea ice conditions, and ocean circulation as marine and terrestrially-based ice sheets waxed and waned. In this work, the acoustic signatures of several glaciated margins in the Northern Hemisphere are investigated and compared. This includes: NW Greenland, West Greenland, East Greenland, mid-Norway, Northern Norway, and the North Sea. These shelf successions preserve a geomorphological record of multiple glaciations and are imaged using seismic reflection data. To date, the majority of work in these areas has tended to focus on the most recent glaciations, which are well known. Here, the focus of the work is to look at the overall stratigraphic setting and how it influences (and is influenced by) the evolution of ice sheets throughout the glacial succession. Landform records are imaged using seismic data to provide a long-term insight into the styles of glaciation on each margin and what relation this may have had on climate, whilst the stratigraphic architectures across each site demonstrate how the inherited geology and tectonic setting can provide a fundamental control on the ice sheet and depositional styles. For example, Scoresby Sund is characterised by significant aggradation that is likely related to subsidence induced by lithospheric cooling rather than rapid glacial deposition, whilst the subsidence of the mid-Norwegian margin can be related to rapid glacial deposition and trapping of sediments behind inversion structures such as the Helland-Hansen Arch. The insights from this multi-margin study allow for regional, basin-wide, glaciological records to be developed

Critical conditions for rill initiation

Treesearch

C. Yao; T. Lei; W. J. Elliot; D. K. McCool; J. Zhao; S. Chen

2008-01-01

Quantifying critical conditions of rill formation can be useful for a better understanding of soil erosion processes. Current studies lack a consensus and related rationale on how to describe these conditions. This study was based on the concepts that (1) the shear stress available for erosion at any given point is a function of the runoff rate, the slope steepness,...

Positive Surgical Margins in Favorable-Stage Differentiated Thyroid Cancer.

PubMed

Mercado, Catherine E; Drew, Peter A; Morris, Christopher G; Dziegielewski, Peter T; Mendenhall, William M; Amdur, Robert J

2018-04-16

The significance of positive margin in favorable-stage well-differentiated thyroid cancer is controversial. We report outcomes of positive-margin patients with a matched-pair comparison to a negative-margin group. A total of 25 patients with classic-histology papillary or follicular carcinoma, total thyroidectomy +/- node dissection, stage T1-3N0-1bM0, positive surgical margin at primary site, adjuvant radioactive iodine (I-131), and age older than 18 years were treated between 2003 and 2013. Endpoints were clinical and biochemical (thyroglobulin-only) recurrence-free survival. Matched-pair analysis involved a 1:1 match with negative-margin cases matched for overall stage and I-131 dose. Recurrence-free survival in positive-margin patients was 71% at 10 years. No patient was successfully salvaged with additional treatment. Only 1 patient died of thyroid cancer. Recurrence-free survival at 10 years was worse with a positive (71%) versus negative (90%) margin (P=0.140). Cure with a microscopically positive margin was suboptimal (71%) despite patients having classic-histology papillary and follicular carcinoma, favorable stage, and moderate-dose I-131 therapy.

SU-E-J-30: Benchmark Image-Based TCP Calculation for Evaluation of PTV Margins for Lung SBRT Patients

DOE Office of Scientific and Technical Information (OSTI.GOV)

Li, M; Chetty, I; Zhong, H

2014-06-01

Purpose: Tumor control probability (TCP) calculated with accumulated radiation doses may help design appropriate treatment margins. Image registration errors, however, may compromise the calculated TCP. The purpose of this study is to develop benchmark CT images to quantify registration-induced errors in the accumulated doses and their corresponding TCP. Methods: 4DCT images were registered from end-inhale (EI) to end-exhale (EE) using a “demons” algorithm. The demons DVFs were corrected by an FEM model to get realistic deformation fields. The FEM DVFs were used to warp the EI images to create the FEM-simulated images. The two images combined with the FEM DVFmore » formed a benchmark model. Maximum intensity projection (MIP) images, created from the EI and simulated images, were used to develop IMRT plans. Two plans with 3 and 5 mm margins were developed for each patient. With these plans, radiation doses were recalculated on the simulated images and warped back to the EI images using the FEM DVFs to get the accumulated doses. The Elastix software was used to register the FEM-simulated images to the EI images. TCPs calculated with the Elastix-accumulated doses were compared with those generated by the FEM to get the TCP error of the Elastix registrations. Results: For six lung patients, the mean Elastix registration error ranged from 0.93 to 1.98 mm. Their relative dose errors in PTV were between 0.28% and 6.8% for 3mm margin plans, and between 0.29% and 6.3% for 5mm-margin plans. As the PTV margin reduced from 5 to 3 mm, the mean TCP error of the Elastix-reconstructed doses increased from 2.0% to 2.9%, and the mean NTCP errors decreased from 1.2% to 1.1%. Conclusion: Patient-specific benchmark images can be used to evaluate the impact of registration errors on the computed TCPs, and may help select appropriate PTV margins for lung SBRT patients.« less

Quantitative measurement of marginal disintegration of ceramic inlays.

PubMed

Hayashi, Mikako; Tsubakimoto, Yuko; Takeshige, Fumio; Ebisu, Shigeyuki

2004-01-01

The objectives of this study include establishing a method for quantitative measurement of marginal change in ceramic inlays and clarifying their marginal disintegration in vivo. An accurate CCD optical laser scanner system was used for morphological measurement of the marginal change of ceramic inlays. The accuracy of the CCD measurement was assessed by comparing it with microscopic measurement. Replicas of 15 premolars restored with Class II ceramic inlays at the time of placement and eight years after restoration were used for morphological measurement by means of the CCD laser scanner system. Occlusal surfaces of the restored teeth were scanned and cross-sections of marginal areas were computed with software. Marginal change was defined as the area enclosed by two profiles obtained by superimposing two cross-sections of the same location at two different times and expressing the maximum depth and mean area of the area enclosed. The accuracy of this method of measurement was 4.3 +/- 3.2 microm in distance and 2.0 +/- 0.6% in area. Quantitative marginal changes for the eight-year period were 10 x 10 microm in depth and 50 x 10(3) microm2 in area at the functional cusp area and 7 x 10 microm in depth and 28 x 10(3) microm2 in area at the non-functional cusp area. Marginal disintegration at the functional cusp area was significantly greater than at the non-functional cusp area (Wilcoxon signed-ranks test, p < 0.05). This study constitutes a quantitative measurement of in vivo deterioration in marginal adaptation of ceramic inlays and indicates that occlusal force may accelerate marginal disintegration.

Productivity, biomass partitioning, and energy yield of low-input short-rotation American sycamore (Platanus occidentalis L.) grown on marginal land: Effects of planting density and simulated drought

Treesearch

Jean-Christophe Domec; Elissa Ashley; Milan Fischer; Asko Noormets; Jameson Boone; James C. Williamson; John S. King

2017-01-01

Short-rotation woody crops (SRWC) grown for bioenergy production are considered a more sustainable feedstock than food crops such as corn and soybean. However, to be sustainable SRWC should be deployed on land not suitable for agriculture (e.g., marginal lands). Here we quantified productivity and energy yield of four SRWC candidate species grown at different planting...

Comparative biogeochemistry-ecosystem-human interactions on dynamic continental margins

USGS Publications Warehouse

Levin, Lisa A.; Liu, Kon-Kee; Emeis, Kay-Christian; Breitburg, Denise L.; Cloern, James; Deutsch, Curtis; Giani, Michele; Goffart, Anne; Hofmann, Eileen E.; Lachkar, Zouhair; Limburg, Karin; Liu, Su-Mei; Montes, Enrique; Naqvi, Wajih; Ragueneau, Olivier; Rabouille, Christophe; Sarkar, Santosh Kumar; Swaney, Dennis P.; Wassman, Paul; Wishner, Karen F.

2014-01-01

The ocean’s continental margins face strong and rapid change, forced by a combination of direct human activity, anthropogenic CO2-induced climate change, and natural variability. Stimulated by discussions in Goa, India at the IMBER IMBIZO III, we (1) provide an overview of the drivers of biogeochemical variation and change on margins, (2) compare temporal trends in hydrographic and biogeochemical data across different margins (3) review ecosystem responses to these changes, (4) highlight the importance of margin time series for detecting and attributing change and (5) examine societal responses to changing margin biogeochemistry and ecosystems. We synthesize information over a wide range of margin settings in order to identify the commonalities and distinctions among continental margin ecosystems. Key drivers of biogeochemical variation include long-term climate cycles, CO2-induced warming, acidification, and deoxygenation, as well as sea level rise, eutrophication, hydrologic and water cycle alteration, changing land use, fishing, and species invasion. Ecosystem responses are complex and impact major margin services including primary production, fisheries production, nutrient cycling, shoreline protection, chemical buffering, and biodiversity. Despite regional differences, the societal consequences of these changes are unarguably large and mandate coherent actions to reduce, mitigate and adapt to multiple stressors on continental margins.

Comparative biogeochemistry-ecosystem-human interactions on dynamic continental margins

NASA Astrophysics Data System (ADS)

Levin, Lisa A.; Liu, Kon-Kee; Emeis, Kay-Christian; Breitburg, Denise L.; Cloern, James; Deutsch, Curtis; Giani, Michele; Goffart, Anne; Hofmann, Eileen E.; Lachkar, Zouhair; Limburg, Karin; Liu, Su-Mei; Montes, Enrique; Naqvi, Wajih; Ragueneau, Olivier; Rabouille, Christophe; Sarkar, Santosh Kumar; Swaney, Dennis P.; Wassman, Paul; Wishner, Karen F.

2015-01-01

The oceans' continental margins face strong and rapid change, forced by a combination of direct human activity, anthropogenic CO2-induced climate change, and natural variability. Stimulated by discussions in Goa, India at the IMBER IMBIZO III, we (1) provide an overview of the drivers of biogeochemical variation and change on margins, (2) compare temporal trends in hydrographic and biogeochemical data across different margins, (3) review ecosystem responses to these changes, (4) highlight the importance of margin time series for detecting and attributing change and (5) examine societal responses to changing margin biogeochemistry and ecosystems. We synthesize information over a wide range of margin settings in order to identify the commonalities and distinctions among continental margin ecosystems. Key drivers of biogeochemical variation include long-term climate cycles, CO2-induced warming, acidification, and deoxygenation, as well as sea level rise, eutrophication, hydrologic and water cycle alteration, changing land use, fishing, and species invasion. Ecosystem responses are complex and impact major margin services. These include primary production, fisheries production, nutrient cycling, shoreline protection, chemical buffering, and biodiversity. Despite regional differences, the societal consequences of these changes are unarguably large and mandate coherent actions to reduce, mitigate and adapt to multiple stressors on continental margins.

Critical Race Theory as Ordinary Theology of African American Principals

ERIC Educational Resources Information Center

Witherspoon, Noelle; Mitchell, Roland W.

2009-01-01

William Tate proposed that critical race scholars in education look to moral and spiritual texts to unpack and interrogate the workings of race and other forms of marginalization in schools. While Tate did not offer the ways in which this vision is manifest, the participants in this study situated themselves within a religio-spiritual worldview…

A quantitative microscopic approach to predict local recurrence based on in vivo intraoperative imaging of sarcoma tumor margins

PubMed Central

Mueller, Jenna L.; Fu, Henry L.; Mito, Jeffrey K.; Whitley, Melodi J.; Chitalia, Rhea; Erkanli, Alaattin; Dodd, Leslie; Cardona, Diana M.; Geradts, Joseph; Willett, Rebecca M.; Kirsch, David G.; Ramanujam, Nimmi

2015-01-01

The goal of resection of soft tissue sarcomas located in the extremity is to preserve limb function while completely excising the tumor with a margin of normal tissue. With surgery alone, one-third of patients with soft tissue sarcoma of the extremity will have local recurrence due to microscopic residual disease in the tumor bed. Currently, a limited number of intraoperative pathology-based techniques are used to assess margin status; however, few have been widely adopted due to sampling error and time constraints. To aid in intraoperative diagnosis, we developed a quantitative optical microscopy toolbox, which includes acriflavine staining, fluorescence microscopy, and analytic techniques called sparse component analysis and circle transform to yield quantitative diagnosis of tumor margins. A series of variables were quantified from images of resected primary sarcomas and used to optimize a multivariate model. The sensitivity and specificity for differentiating positive from negative ex vivo resected tumor margins was 82% and 75%. The utility of this approach was tested by imaging the in vivo tumor cavities from 34 mice after resection of a sarcoma with local recurrence as a bench mark. When applied prospectively to images from the tumor cavity, the sensitivity and specificity for differentiating local recurrence was 78% and 82%. For comparison, if pathology was used to predict local recurrence in this data set, it would achieve a sensitivity of 29% and a specificity of 71%. These results indicate a robust approach for detecting microscopic residual disease, which is an effective predictor of local recurrence. PMID:25994353

An Algorithm for Critical Nodes Problem in Social Networks Based on Owen Value

PubMed Central

Wang, Xue-Guang

2014-01-01

Discovering critical nodes in social networks has many important applications. For finding out the critical nodes and considering the widespread community structure in social networks, we obtain each node's marginal contribution by Owen value. And then we can give a method for the solution of the critical node problem. We validate the feasibility and effectiveness of our method on two synthetic datasets and six real datasets. At the same time, the result obtained by using our method to analyze the terrorist network is in line with the actual situation. PMID:25006592

Thrombotic microangiopathy in marginal kidneys after sirolimus use.

PubMed

Pellé, Gaëlle; Xu, Ychen; Khoury, Noujoud; Mougenot, Béatrice; Rondeau, Eric

2005-12-01

The increasing shortage of cadaver donor kidneys has prompted the use of expanded or marginal donor kidneys, ie, from older donors or those with a history of hypertension or diabetes. These marginal kidneys may be especially susceptible to calcineurin inhibitor (CNI)-mediated vasoconstriction and nephrotoxicity. Recipients of renal transplants from marginal donors therefore require non-nephrotoxic immunosuppression. Some investigators have proposed using sirolimus, a novel and potent immunosuppressant, instead of CNIs. Moreover, another complication of solid-organ transplantation is thrombotic microangiopathy (TMA), which affects 3% to 14% of patients on immunosuppression therapy treated with CNIs. Therefore, it was suggested that CNIs may be substituted by sirolimus in patients with posttransplantation CNI-induced TMA. We report 3 patients who received marginal cadaveric kidneys and were administered maintenance immunosuppression with sirolimus, prednisone, and mycophenolate mofetil. They each developed de novo TMA despite never having been previously administered a CNI. In these cases, TMA occurred in marginal kidneys with possible endothelial injury before transplantation. Sirolimus may have prevented recovery from these injuries and thus may have promoted TMA in these marginal kidneys. The risk for such a vascular complication should be kept in mind in patients who receive marginal kidneys and are administered sirolimus, even when sirolimus is used without CNIs.

Quantifying resilience

USGS Publications Warehouse

Allen, Craig R.; Angeler, David G.

2016-01-01

Several frameworks to operationalize resilience have been proposed. A decade ago, a special feature focused on quantifying resilience was published in the journal Ecosystems (Carpenter, Westley & Turner 2005). The approach there was towards identifying surrogates of resilience, but few of the papers proposed quantifiable metrics. Consequently, many ecological resilience frameworks remain vague and difficult to quantify, a problem that this special feature aims to address. However, considerable progress has been made during the last decade (e.g. Pope, Allen & Angeler 2014). Although some argue that resilience is best kept as an unquantifiable, vague concept (Quinlan et al. 2016), to be useful for managers, there must be concrete guidance regarding how and what to manage and how to measure success (Garmestani, Allen & Benson 2013; Spears et al. 2015). Ideas such as ‘resilience thinking’ have utility in helping stakeholders conceptualize their systems, but provide little guidance on how to make resilience useful for ecosystem management, other than suggesting an ambiguous, Goldilocks approach of being just right (e.g. diverse, but not too diverse; connected, but not too connected). Here, we clarify some prominent resilience terms and concepts, introduce and synthesize the papers in this special feature on quantifying resilience and identify core unanswered questions related to resilience.

The Meandering Margin of the Meteorological Moist Tropics

NASA Astrophysics Data System (ADS)

Mapes, Brian E.; Chung, Eui Seok; Hannah, Walter M.; Masunaga, Hirohiko; Wimmers, Anthony J.; Velden, Christopher S.

2018-01-01

Bimodally distributed column water vapor (CWV) indicates a well-defined moist regime in the Tropics, above a margin value near 48 kg m-2 in current climate (about 80% of column saturation). Maps reveal this margin as a meandering, sinuous synoptic contour bounding broad plateaus of the moist regime. Within these plateaus, convective storms of distinctly smaller convective and mesoscales occur sporadically. Satellite data composites across the poleward most margin reveal its sharpness, despite the crude averaging: precipitation doubles within 100 km, marked by both enhancement and deepening of cloudiness. Transported patches and filaments of the moist regime cause consequential precipitation events within and beyond the Tropics. Distinguishing synoptic flows that cross the margin from flows that move the margin is made possible by a novel satellite-based Lagrangian CWV tendency estimate. Climate models do not reliably reproduce the observed bimodal distribution, so studying the moist mode's maintenance processes and the margin-zone air mass transformations, guided by the Lagrangian tendency product, might importantly constrain model moist process treatments.

Continental margin sedimentation: From sediment transport to sequence stratigraphy

USGS Publications Warehouse

Nittrouer, Charles A.; Austin, James A.; Field, Michael E.; Kravitz, Joseph H.; Syvitski, James P. M.; Wiberg, Patricia L.

2007-01-01

This volume on continental margin sedimentation brings together an expert editorial and contributor team to create a state-of-the-art resource. Taking a global perspective, the book spans a range of timescales and content, ranging from how oceans transport particles, to how thick rock sequences are formed on continental margins.- Summarizes and integrates our understanding of sedimentary processes and strata associated with fluvial dispersal systems on continental shelves and slopes- Explores timescales ranging from particle transport at one extreme, to deep burial at the other- Insights are presented for margins in general, and with focus on a tectonically active margin (northern California) and a passive margin (New Jersey), enabling detailed examination of the intricate relationships between a wide suite of sedimentary processes and their preserved stratigraphy- Includes observational studies which document the processes and strata found on particular margins, in addition to numerical models and laboratory experimentation, which provide a quantitative basis for extrapolation in time and space of insights about continental-margin sedimentation- Provides a research resource for scientists studying modern and ancient margins, and an educational text for advanced students in sedimentology and stratigraphy

Jamming criticality revealed by removing localized buckling excitations.

PubMed

Charbonneau, Patrick; Corwin, Eric I; Parisi, Giorgio; Zamponi, Francesco

2015-03-27

Recent theoretical advances offer an exact, first-principles theory of jamming criticality in infinite dimension as well as universal scaling relations between critical exponents in all dimensions. For packings of frictionless spheres near the jamming transition, these advances predict that nontrivial power-law exponents characterize the critical distribution of (i) small interparticle gaps and (ii) weak contact forces, both of which are crucial for mechanical stability. The scaling of the interparticle gaps is known to be constant in all spatial dimensions d-including the physically relevant d=2 and 3, but the value of the weak force exponent remains the object of debate and confusion. Here, we resolve this ambiguity by numerical simulations. We construct isostatic jammed packings with extremely high accuracy, and introduce a simple criterion to separate the contribution of particles that give rise to localized buckling excitations, i.e., bucklers, from the others. This analysis reveals the remarkable dimensional robustness of mean-field marginality and its associated criticality.

A viscoplastic shear-zone model for deep (15-50 km) slow-slip events at plate convergent margins

NASA Astrophysics Data System (ADS)

Yin, An; Xie, Zhoumin; Meng, Lingsen

2018-06-01

A key issue in understanding the physics of deep (15-50 km) slow-slip events (D-SSE) at plate convergent margins is how their initially unstable motion becomes stabilized. Here we address this issue by quantifying a rate-strengthening mechanism using a viscoplastic shear-zone model inspired by recent advances in field observations and laboratory experiments. The well-established segmentation of slip modes in the downdip direction of a subduction shear zone allows discretization of an interseismic forearc system into the (1) frontal segment bounded by an interseismically locked megathrust, (2) middle segment bounded by episodically locked and unlocked viscoplastic shear zone, and (3) interior segment that slips freely. The three segments are assumed to be linked laterally by two springs that tighten with time, and the increasing elastic stress due to spring tightening eventually leads to plastic failure and initial viscous shear. This simplification leads to seven key model parameters that dictate a wide range of mechanical behaviors of an idealized convergent margin. Specifically, the viscoplastic rheology requires the initially unstable sliding to be terminated nearly instantaneously at a characteristic velocity, which is followed by stable sliding (i.e., slow-slip). The characteristic velocity, which is on the order of <10-7 m/s for the convergent margins examined in this study, depends on the (1) effective coefficient of friction, (2) thickness, (3) depth, and (4) viscosity of the viscoplastic shear zone. As viscosity decreases exponentially with temperature, our model predicts faster slow-slip rates, shorter slow-slip durations, more frequent slow-slip occurrences, and larger slow-slip magnitudes at warmer convergent margins.

Theory and practice in health communication campaigns: a critical interrogation.

PubMed

Dutta-Bergman, Mohan J

2005-01-01

In recent reviews of the body of work on health campaigns, communication scholars discussed the importance of reflective thinking about the capacity of campaigns to effect change; this reflective thinking is especially important in the realm of the increasing gaps in society between the health rich and the health poor and the increasing marginalization of the poorer sections of society. This article critically reviews 3 central theories of health communication campaigns that represent the dominant cognitive approach: theory of reasoned action, health belief model, and the extended parallel process model. After articulating the limitations of these theoretical approaches, the article summarizes new directions in theory, methodology, and application of health communication campaigns targeting marginalized populations.

Margins in breast conserving surgery: The financial cost & potential savings associated with the new margin guidelines.

PubMed

Singer, Lauren; Brown, Eric; Lanni, Thomas

2016-08-01

In this study, we compare the indications for re-excision, the findings of additional tumor in the re-excision specimen as they relate to margin status, and costs associated with re-excision based on recent new consensus statements. A retrospective analysis was performed on 462 patients with invasive breast carcinoma who underwent at least one lumpectomy between January 2011 and December 2013. Postoperative data was analyzed based on where additional disease was found, as it relates to the margin status of the initial lumpectomy and the additional direct costs associated with additional procedures. Of the 462 patients sampled, 149 underwent a re-excision surgery (32.2%). Four patients underwent mastectomy as their second operation. In the 40 patients with additional disease found on re-excision, 36 (90.0%) of them had a positive margin on their initial lumpectomy. None of the four mastectomy patients had residual disease. The mean cost of the initial lumpectomy for all 462 patients was $2118.01 plus an additional $1801.92 for those who underwent re-excision. A positive margin was most predictive of finding residual tumor on re-excision as would be expected. Using old criteria only 0.07% (4/61) of patients who had undergone re-excision with a 'clear' margin, had additional tumor found, at a total cost of $106,354.11. Thus, the new consensus guidelines will lead to less overall cost, at no clinical risk to patients while reducing a patient's surgical risk and essentially eliminating delays in adjuvant care. Copyright © 2016 Elsevier Ltd. All rights reserved.

SU-F-J-130: Margin Determination for Hypofractionated Partial Breast Irradiation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Geady, C; Keller, B; Hahn, E

2016-06-15

Purpose: To determine the Planning Target Volume (PTV) margin for Hypofractionated Partial Breast Irradiation (HPBI) using the van Herk formalism (M=2.5∑+0.7σ). HPBI is a novel technique intended to provide local control in breast cancer patients not eligible for surgical resection, using 40 Gy in 5 fractions prescribed to the gross disease. Methods: Setup uncertainties were quantified through retrospective analysis of cone-beam computed tomography (CBCT) data sets, collected prior to (prefraction) and after (postfraction) treatment delivery. During simulation and treatment, patients were immobilized using a wing board and an evacuated bag. Prefraction CBCT was rigidly registered to planning 4-dimensional computed tomographymore » (4DCT) using the chest wall and tumor, and translational couch shifts were applied as needed. This clinical workflow was faithfully reproduced in Pinnacle (Philips Medical Systems) to yield residual setup and intrafractional error through translational shifts and rigid registrations (ribs and sternum) of prefraction CBCT to 4DCT and postfraction CBCT to prefraction CBCT, respectively. All ten patients included in this investigation were medically inoperable; the median age was 84 (range, 52–100) years. Results: Systematic (and random) setup uncertainties (in mm) detected for the left-right, craniocaudal and anteroposterior directions were 0.4 (1.5), 0.8 (1.8) and 0.4 (1.0); net uncertainty was determined to be 0.7 (1.5). Rotations >2° in any axis occurred on 8/72 (11.1%) registrations. Conclusion: Preliminary results suggest a non-uniform setup margin (in mm) of 2.2, 3.3 and 1.7 for the left-right, craniocaudal and anteroposterior directions is required for HPBI, given its immobilization techniques and online setup verification protocol. This investigation is ongoing, though published results from similar studies are consistent with the above findings. Determination of margins in breast radiotherapy is a paradigm shift, but a

Holding Firm: Power, Push-Back, and Opportunities in Navigating the Liminal Space of Critical Qualitative Health Research.

PubMed

Hart, Corinne; Poole, Jennifer M; Facey, Marcia E; Parsons, Janet A

2017-10-01

Critical qualitative health researchers typically occupy and navigate liminal academic spaces and statuses, with one foot planted in the arts and social sciences and the other in biomedical science. We are at once marginalized and empowered, and this liminality presents both challenges and opportunities. In this article, we draw on our experiences of being (often the lone) critical qualitative health scholars on thesis advisory committees and dissertation examinations, as well as our experiences of publishing and securing funding, to illuminate how power and knowledge relations create conditions that shape the nature of our roles. We share strategies we have developed for standing our theoretical and methodological ground. We discuss how we use the power of our liminality to hold firm, push back, and push forward, to ensure that critical qualitative research is not further relegated to the margins and its quality and integrity sustained.

Estimating long-wavelength dynamic topographic change of passive continental margins since the Early Cretaceous

NASA Astrophysics Data System (ADS)

Müller, Dietmar; Hassan, Rakib; Gurnis, Michael; Flament, Nicolas; Williams, Simon

2017-04-01

-members of dynamic topography evolution along passive margins and their hinterlands, differentiating topographic stability, long-term pronounced subsidence, initial stability over a dynamic high followed by moderate subsidence and regions that are relatively proximal to subduction zones with varied dynamic topography histories. Along passive continental margins the most commonly observed process is a gradual move from dynamic highs towards lows during the fragmentation of Pangea, reflecting that many passive margins now overly slabs sinking in the lower mantle. Our best-fit model results in up to 500 ±150 m of total dynamic subsidence of continental interiors while along passive margins the maximum predicted dynamic topographic change over 140 million years is about 350 ±150 m of subsidence. Models with plumes exhibit clusters of transient passive margin uplift of about 200 ±200m. The good overall match between predicted dynamic topography and geologically mapped paleo-coastlines makes a convincing case that mantle-driven topographic change is a critical component of relative sea level change, and one of the main driving forces generating the observed geometries and timings of large-scale shifts in paleo-coastlines.

Targeted delivery of cancer-specific multimodal contrast agents for intraoperative detection of tumor boundaries and therapeutic margins

NASA Astrophysics Data System (ADS)

Xu, Ronald X.; Xu, Jeff S.; Huang, Jiwei; Tweedle, Michael F.; Schmidt, Carl; Povoski, Stephen P.; Martin, Edward W.

2010-02-01

Background: Accurate assessment of tumor boundaries and intraoperative detection of therapeutic margins are important oncologic principles for minimal recurrence rates and improved long-term outcomes. However, many existing cancer imaging tools are based on preoperative image acquisition and do not provide real-time intraoperative information that supports critical decision-making in the operating room. Method: Poly lactic-co-glycolic acid (PLGA) microbubbles (MBs) and nanobubbles (NBs) were synthesized by a modified double emulsion method. The MB and NB surfaces were conjugated with CC49 antibody to target TAG-72 antigen, a human glycoprotein complex expressed in many epithelial-derived cancers. Multiple imaging agents were encapsulated in MBs and NBs for multimodal imaging. Both one-step and multi-step cancer targeting strategies were explored. Active MBs/NBs were also fabricated for therapeutic margin assessment in cancer ablation therapies. Results: The multimodal contrast agents and the cancer-targeting strategies were tested on tissue simulating phantoms, LS174 colon cancer cell cultures, and cancer xenograft nude mice. Concurrent multimodal imaging was demonstrated using fluorescence and ultrasound imaging modalities. Technical feasibility of using active MBs and portable imaging tools such as ultrasound for intraoperative therapeutic margin assessment was demonstrated in a biological tissue model. Conclusion: The cancer-specific multimodal contrast agents described in this paper have the potential for intraoperative detection of tumor boundaries and therapeutic margins.

Unsteady three-dimensional marginal separation caused by surface-mounted obstacles and/or local suction

NASA Astrophysics Data System (ADS)

Braun, Stefan; Kluwick, Alfred

2004-09-01

Earlier investigations of steady two-dimensional marginally separated laminar boundary layers have shown that the non-dimensional wall shear (or equivalently the negative non-dimensional perturbation displacement thickness) is governed by a nonlinear integro-differential equation. This equation contains a single controlling parameter Gamma characterizing, for example, the angle of attack of a slender airfoil and has the important property that (real) solutions exist up to a critical value Gamma_c of Gamma only. Here we investigate three-dimensional unsteady perturbations of an incompressible steady two-dimensional marginally separated laminar boundary layer with special emphasis on the flow behaviour near Gamma_c. Specifically, it is shown that the integro differential equation which governs these disturbances if Gamma_c {-} Gamma {=} O(1) reduces to a nonlinear partial differential equation known as the Fisher equation as Gamma approaches the critical value Gamma_c. This in turn leads to a significant simplification of the problem allowing, among other things, a systematic study of devices used in boundary-layer control and an analytical investigation of the conditions leading to the formation of finite-time singularities which have been observed in earlier numerical studies of unsteady two-dimensional and three-dimensional flows in the vicinity of a line of symmetry. Also, it is found that it is possible to construct exact solutions which describe waves of constant form travelling in the spanwise direction. These waves may contain singularities which can be interpreted as vortex sheets. The existence of these solutions strongly suggests that solutions of the Fisher equation which lead to finite-time blow-up may be extended beyond the blow-up time, thereby generating moving singularities which can be interpreted as vortical structures qualitatively similar to those emerging in direct numerical simulations of near critical (i.e. transitional) laminar separation

Decline of flounder (Platichthys flesus (L.)) at the margin of the species' distribution range

NASA Astrophysics Data System (ADS)

Jokinen, Henri; Wennhage, Håkan; Lappalainen, Antti; Ådjers, Kaj; Rask, Martti; Norkko, Alf

2015-11-01

The Baltic Sea is undergoing large-scale environmental change due to eutrophication, climate change, over-exploitation and habitat destruction, with subsequent degradation of living conditions for many fish species. Signs of this unfavorable development are seen as population declines in species affected. We provide the first synthesis and characterization of the recent population decline in European flounder (Platichthys flesus (L.)) in the northern Baltic Sea, using available fishery-independent data from the Finnish coast, which is at the margin of the distribution range of this species. The objective was to document recent changes in the flounder population, identify the onset and quantify the magnitude of the change. The results showed substantial decreases in flounder numbers and biomass across the whole study area during recent decades. Based on the time series data available, flounder abundances declined by 46-97% from the 1990s to the 2000s, with top values in the mid-1990s and current low levels reached in the early 2000s. Additionally, signs of decreasing flounder size and condition were also observed. We discuss potential reasons for the development in terms of environmental change and fishing, and identify potential bottlenecks for population maintenance and mechanisms behind population change, thereby contributing to our general understanding of marginal flounder populations.

TU-AB-303-06: Does Online Adaptive Radiation Therapy Mean Zero Margin for Intermediate-Risk Prostate Cancer? An Intra-Fractional Seminal Vesicles Motion Analysis

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sheng, Y; Li, T; Lee, W

Purpose: To provide benchmark for seminal vesicles (SVs) margin selection to account for intra-fractional motion; and to investigate the effectiveness of two motion surrogates in predicting intra-fractional SV underdosage. Methods: 9 prostate SBRT patients were studied; each has five pairs of pre-treatment and post-treatment cone-beam CTs (CBCTs). Each pair of CBCTs was registered based on fiducial markers in the prostate. To provide “ground truth” for coverage evaluation, all pre-treatment SVs were expanded with isotropic margin of 1,2,3,5 and 8mm, and their overlap with post-treatment SVs were used to quantify intra-fractional coverage. Two commonly used motion surrogates, the center-of-mass (COM) andmore » the border of contour (the most distal points in SI/AP/LR directions) were evaluated using Receiver-Operating Characteristic (ROC) analyses for predicting SV underdosage due to intra-fractional motion. Action threshold of determining underdosage for each surrogate was calculated by selecting the optimal balancing between sensitivity and specificity. For comparison, margin for each surrogate was also calculated based on traditional margin recipe. Results: 90% post-treatment SV coverage can be achieved in 47%, 82%, 91%, 98% and 98% fractions for 1,2,3,5 and 8mm margins. 3mm margin ensured the 90% intra-fractional SV coverage in 90% fractions when prostate was aligned. The ROC analysis indicated the AUC for COM and border were 0.88 and 0.72. The underdosage threshold was 2.9mm for COM and 4.1mm for border. The Van Herk’s margin recipe recommended 0.5, 0 and 1.8mm margin in LR, AP and SI direction based on COM and for border, the corresponding margin was 2.1, 4.5 and 3mm. Conclusion: 3mm isotropic margin is the minimum required to mitigate the intra-fractional SV motion when prostate is aligned. ROC analysis reveals that both COM and border are acceptable predictors for SV underdosage with 2.9mm and 4.1mm action threshold. Traditional margin calculation is

Colorado Basin Structure and Rifting, Argentine passive margin

NASA Astrophysics Data System (ADS)

Autin, Julia; Scheck-Wenderoth, Magdalena; Loegering, Markus; Anka, Zahie; Vallejo, Eduardo; Rodriguez, Jorge; Marchal, Denis; Reichert, Christian; di Primio, Rolando

2010-05-01

The Argentine margin presents a strong segmentation with considerable strike-slip movements along the fracture zones. We focus on the volcanic segment (between the Salado and Colorado transfer zones), which is characterized by seaward dipping reflectors (SDR) all along the ocean-continent transition [e.g. Franke et al., 2006; Gladczenko et al., 1997; Hinz et al., 1999]. The segment is structured by E-W trending basins, which differs from the South African margin basins and cannot be explained by classical models of rifting. Thus the study of the relationship between the basins and the Argentine margin itself will allow the understanding of their contemporary development. Moreover the comparison of the conjugate margins suggests a particular evolution of rifting and break-up. We firstly focus on the Colorado Basin, which is thought to be the conjugate of the well studied Orange Basin [Hirsch et al., 2009] at the South African margin [e.g. Franke et al., 2006]. This work presents results of a combined approach using seismic interpretation and structural, isostatic and thermal modelling highlighting the structure of the crust. The seismic interpretation shows two rift-related discordances: one intra syn-rift and the break-up unconformity. The overlying sediments of the sag phase are less deformed (no sedimentary wedges) and accumulated before the generation of oceanic crust. The axis of the Colorado Basin trends E-W in the western part, where the deepest pre-rift series are preserved. In contrast, the basin axis turns to a NW-SE direction in its eastern part, where mainly post-rift sediments accumulated. The most distal part reaches the margin slope and opens into the oceanic basin. The general basin direction is almost orthogonal to the present-day margin trend. The most frequent hypothesis explaining this geometry is that the Colorado Basin is an aborted rift resulting from a previous RRR triple junction [e.g. Franke et al., 2002]. The structural interpretation

Quantifying the Impact of Unavailability in Cyber-Physical Environments

DOE Office of Scientific and Technical Information (OSTI.GOV)

Aissa, Anis Ben; Abercrombie, Robert K; Sheldon, Federick T.

2014-01-01

The Supervisory Control and Data Acquisition (SCADA) system discussed in this work manages a distributed control network for the Tunisian Electric & Gas Utility. The network is dispersed over a large geographic area that monitors and controls the flow of electricity/gas from both remote and centralized locations. The availability of the SCADA system in this context is critical to ensuring the uninterrupted delivery of energy, including safety, security, continuity of operations and revenue. Such SCADA systems are the backbone of national critical cyber-physical infrastructures. Herein, we propose adapting the Mean Failure Cost (MFC) metric for quantifying the cost of unavailability.more » This new metric combines the classic availability formulation with MFC. The resulting metric, so-called Econometric Availability (EA), offers a computational basis to evaluate a system in terms of the gain/loss ($/hour of operation) that affects each stakeholder due to unavailability.« less

The Seismicity of Two Hyperextended Margins

NASA Astrophysics Data System (ADS)

Redfield, Tim; Terje Osmundsen, Per

2013-04-01

A seismic belt marks the outermost edge of Scandinavia's proximal margin, inboard of and roughly parallel to the Taper Break. A similar near- to onshore seismic belt runs along its inner edge, roughly parallel to and outboard of the asymmetric, seaward-facing escarpment. The belts converge at both the northern and southern ends of Scandinavia, where crustal taper is sharp and the proximal margin is narrow. Very few seismic events have been recorded on the intervening, gently-tapering Trøndelag Platform. Norway's distribution of seismicity is systematically ordered with respect to 1) the structural templates of high-beta extension that shaped the thinning gradient during Late Jurassic or Early Cretaceous time, and 2) the topographically resurgent Cretaceous-Cenozoic "accommodation phase" family of escarpments that approximate the innermost limit of crustal thinning [See Redfield and Osmundsen (2012) for diagrams, definitions, discussion, and supporting citations.] Landwards from the belt of earthquake epicenters that mark the Taper Break the crust consistently thickens, and large fault arrays tend to sole out at mid crustal levels. Towards the sea the crystalline continental crust is hyperextended, pervasively faulted, and generally very thin. Also, faulting and serpentinization may have affected the uppermost parts of the distal margin's lithospheric mantle. Such contrasting structural conditions may generate a contrasting stiffness: for a given stress, more strain can be accommodated in the distal margin than in the less faulted proximal margin. By way of comparison, inboard of the Taper Break on the gently-tapered Trøndelag Platform, faulting was not penetrative. There, similar structural conditions prevail and proximal margin seismicity is negligible. Because stress concentration can occur where material properties undergo significant contrast, the necking zone may constitute a natural localization point for post-thinning phase earthquakes. In Scandinavia

Marginally outer trapped surfaces and symmetries

NASA Astrophysics Data System (ADS)

Carrasco, Alberto; Mars, Marc

2009-05-01

We study properties of outermost marginally outer trapped surfaces in slices of space-times possessing certain symmetries, like isometries, homotheties or conformal Killings. In particular, we find restrictions on these surfaces for the vector field generating the symmetry. As an application we give a result of non-existence of outermost marginally outer trapped surfaces in accelerated Friedmann-Lemaître-Roberson-Walker spacetimes.

Tectono-magmatic evolution at distal magma-poor rifted margins: insights of the lithospheric breakup at the Australia-Antarctica margins.

NASA Astrophysics Data System (ADS)

Gillard, Morgane; Autin, Julia; Manatschal, Gianreto

2015-04-01

The discovery of large domains of hyper-extended continental crust and exhumed mantle along many present-day magma-poor rifted margins questions the processes that play during the lithospheric breakup and the onset of seafloor spreading. In particular, the amount of magma and its relation to tectonic structures is yet little understood. Trying to find answers to these questions asks to work at the most distal parts of rifted margins where the transition from rifting to steady state seafloor spreading occurred. The Australian-Antarctic conjugated margins provide an excellent study area. Indeed, the central sector of the Great Australian Bight/Wilkes Land developed in a magma-poor probably ultra-slow setting and displays a complex and not yet well understood Ocean-Continent Transition (OCT). This distal area is well imaged by numerous high quality seismic lines covering the whole OCT and the steady-state oceanic crust. The deformation recorded in the sedimentary units along these margins highlights a migration of the deformation toward the ocean and a clear polyphase evolution. In particular, the observation that each tectono-sedimentary unit downlaps oceanwards onto the basement suggests that final rifting is associated with the creation of new depositional ground under conditions that are not yet those of a steady state oceanic crust. These observations lead to a model of evolution for these distal margins implying the development of multiple detachment systems organizing out-of-sequence, each new detachment fault developing into the previously exhumed basement. This spatial and temporal organization of fault systems leads to a final symmetry of exhumed domains at both conjugated margins. Magma appears to gradually increase during the margin development and is particularly present in the more distal domain where we can observe clear magma/fault interactions. We propose that the evolution of such rifted margins is linked to cycles of delocalisation

"More Complicated than a Numbers Game": A Critical Race Theory Examination of Asian Americans and Campus Racial Climate

ERIC Educational Resources Information Center

Poon, Oi Yan Anita

2010-01-01

In the Grutter and Gratz Supreme Court decision, proponents of affirmative action claimed that a critical mass of minority students could effectively counter racial marginalization often experienced by students of color due to their racial status. On some campuses, Asian Americans as a pan-ethnic population enjoy a critical mass in undergraduate…

Intraoperative ultrasound control of surgical margins during partial nephrectomy.

PubMed

Alharbi, Feras M; Chahwan, Charles K; Le Gal, Sophie G; Guleryuz, Kerem M; Tillou, Xavier P; Doerfler, Arnaud P

2016-01-01

To evaluate a simple and fast technique to ensure negative surgical margins on partial nephrectomies, while correlating margin statuses with the final pathology report. This study was conducted for patients undergoing partial nephrectomy (PN) with T1-T2 renal tumors from January 2010 to the end of December 2015. Before tumor removal, intraoperative ultrasound (US) localization was performed. After tumor removal and before performing hemostasis of the kidney, the specimens were placed in a saline solution and a US was performed to evaluate if the tumor's capsule were intact, and then compared to the final pathology results. In 177 PN(s) (147 open procedures and 30 laparoscopic procedures) were performed on 147 patients. Arterial clamping was done for 32 patients and the mean warm ischemia time was 19 ± 6 min. The mean US examination time was 41 ± 7 s. The US analysis of surgical margins was negative in 172 cases, positive in four, and in only one case it was not possible to conclude. The final pathology results revealed one false positive surgical margin and one false negative surgical margin, while all other margins were in concert with US results. The mean tumor size was 3.53 ± 1.43 cm, and the mean surgical margin was 2.8 ± 1.5 mm. The intraoperative US control of resection margins in PN is a simple, efficient, and effective method for ensuring negative surgical margins with a small increase in warm ischemia time and can be conducted by the operating urologist.

Role of fluctuations in random compressible systems at marginal dimensionality

NASA Astrophysics Data System (ADS)

Meissner, G.; Sasvári, L.; Tadić, B.

1986-07-01

In a unified treatment we have studied the role of fluctuations in uniaxial random systems at marginal dimensionality d*=4 with the n=1 component order parameter being coupled to elastic degrees of freedom. Depending on the ratio of the nonuniversal parameters of quenched disorder Δ0 and of elastic fluctuations v~0, a first- or second-order phase transition is found to occur, separated by a tricritical point. A complete account of critical properties and of macroscopic as well as of microscopic elastic stability is given for temperatures T>Tc. Universal singularities of thermodynamic functions are determined for t=(T-Tc)/Tc-->0 including the tricritical point: for v~0/Δ0>-2, they are the same as in a rigid random system; for v~0/Δ0=-2, they are different due to lattice compressibility being related, however, to the former by Fisher renormalization. Fluctuation corrections in one-loop approximation have been evaluated in a nonuniversal critical temperature range, tx<critical regime. The latter apparently becomes extremely narrow due to the order of magnitude being obtained for tx whose origin is in a peculiar degeneracy of the renormalization-group (RG) equations in leading order. In solving these RG recursion relations in the nonuniversal regime exactly, analytic expressions for thermodynamic functions have been obtained improving a recent approach for rigid random systems. The nonuniversal critical behavior can be characterized by effective exponents varying continuously with Δ0 and v~0. We have also estimated numerically limits of the validity of the one-loop approximation. The temperature dependence of the elastic constants has been obtained for the entire region of temperatures. The critical behavior of random compressible systems, unlike that of pure compressible systems, is finally shown to remain stable against weak lattice anisotropy.

Invasive vulvar carcinoma and the question of the surgical margin.

PubMed

Palaia, Innocenza; Bellati, Filippo; Calcagno, Marco; Musella, Angela; Perniola, Giorgia; Panici, Pierluigi B

2011-08-01

To assess the discrepancy between width of surgical margin measured with the naked eye/ruler by a surgeon before removing an invasive vulvar carcinoma, and width of margin measured under microscope by pathologist after fixation of the resected lesion with formalin. Potential relationships between discrepancy and disease recurrence were also investigated. This prospective study was conducted with resected lesions from 86 women who underwent surgery for primary/recurrent invasive vulvar carcinoma. After the surgeon removed the lesions surrounded by 1-2-cm margins, the pathologist determined margin width at the 4 cardinal points of 86 lesions (for a total of 344 margin assessments), first macroscopically and then under the microscope. A safety margin of 0.8 cm on microscopic view was achieved in 83% of cases (112 of 135) when the macroscopic measurement was 1cm, in 91% of cases (58 of 64) when it was 1.5 cm, and 98% of cases (105 of 107) when it was 2 cm. There was a small discrepancy between the surgeon's intent and the microscopic margin measurement, mostly related to tissue shrinkage. A 1-cm surgical margin corresponded to a 0.8-cm margin in microscopic view (the "safe margin") in most cases. Copyright © 2011 International Federation of Gynecology and Obstetrics. Published by Elsevier Ireland Ltd. All rights reserved.

Trichomonas vaginalis Infection and Associated Risk Factors in a Socially-Marginalized Female Population in Coastal Peru

PubMed Central

Leon, Segundo R.; Konda, Kelika A.; Bernstein, Kyle T.; Pajuelo, Jose B.; Rosasco, Ana M.; Caceres, Carlos F.; Coates, Thomas J.; Klausner, Jeffrey D.

2009-01-01

Objective. The epidemiology of Trichomonas vaginalis infection among sexually active socially-marginalized women in three urban, coastal Peruvian cities was examined in order to quantify the prevalence of trichomonas infection and identify associated risk factors. Methods. We conducted a cross-sectional, venue-based study of women from socially-marginalized populations in three coastal Peruvian cities. Results. Among the 319 women enrolled, the overall prevalence of trichomonal infection was 9.1% (95% CI, 5.9%–12.3%). The mean age was 26.3 years, and 35.5% reported having had unprotected intercourse with nonprimary partners and 19.8% reported two or more sex partners in the last three months. Trichomonal infection was associated with increased number of sex partners (PR 2.5, 95% CI 1.4–4.6) and unprotected sex with nonprimary partner in the last three months (PR 2.3, 95% CI 1.1–4.9). Conclusions. A moderately high prevalence of trichomonal infection was found among women in our study. Trichomonal infection was associated with unprotected sex and multiple sex partners. Efforts to control the continued spread of trichomonal infection are warranted. PMID:19584943

17 CFR 242.404 - Type, form and use of margin.

Code of Federal Regulations, 2010 CFR

2010-04-01

... (CONTINUED) REGULATIONS M, SHO, ATS, AC, AND NMS AND CUSTOMER MARGIN REQUIREMENTS FOR SECURITY FUTURES Customer Margin Requirements for Security Futures § 242.404 Type, form and use of margin. (a) When margin... (§§ 242.400 through 242.406), provided that: (i) The customer waives any right to redeem the shares...

Implications of arcing due to spacecraft charging on spacecraft EMI margins of immunity

NASA Technical Reports Server (NTRS)

Inouye, G. T.

1981-01-01

Arcing due to spacecraft charging on spacecraft EMI margins of immunity was determined. The configuration of the P78-2 spacecraft of the SCATHA program was analyzed. A brushfire arc discharge model was developed, and a technique for initiating discharges with a spark plug trigger was for data configuration. A set of best estimate arc discharge parameters was defined. The effects of spacecraft potentials in limiting the discharge current blowout component are included. Arc discharge source models were incorporated into a SEMCAP EMI coupling analysis code for the DSP spacecraft. It is shown that with no mission critical circuits will be affected.

Margins in Skin Excision Biopsies: Principles and Guidelines

PubMed Central

Ranjan, Richa; Singh, Lavleen; Arava, Sudheer K; Singh, Manoj Kumar

2014-01-01

Skin biopsies are usually undertaken to confirm a clinical diagnosis, to remove a lesion, and to determine the adequacy of excised tissue margin. A surgical margin is technically defined as the “edge” of the tissue removed. The term is especially pertinent when the tissue excised is suspected of being involved by a malignant process. One of the most important predictive and prognostic factors of a malignant lesion is whether the margins of the resected specimen are involved by the tumor or not. The purpose of this review is to provide an insight into grossing of a skin biopsy specimen with emphasis on techniques and reporting of excision biopsy margins. PMID:25484385

Mission, Margin, and the Role of Consumer Governance in Decision-Making at Community Health Centers

PubMed Central

Wright, Brad; Martin, Graham P.

2017-01-01

Objective We explore the role of consumer trustees in decision-making as community health centers (CHCs) work to navigate the tension between pursuing their mission to provide primary care to all regardless of ability to pay and maintaining their limited finances. Methods We interviewed 30 trustees from 16 CHCs in 14 different states, asking extensively about decision-making processes at their CHC related to services and finances, as well as perceived advantages and disadvantages of consumer governance. Results Respondents described mission-dominant, margin-dominant, and balanced decision-making philosophies, and different decision-making pathways for service provision and finances. Consumer trustees were lauded for their role in informing the board of service quality and community needs, but criticized for being professionally unskilled and exhibiting a lack of objective decision-making. Conclusions While CHC boards do play a role in navigating the tension between mission and margin, executive directors and staff appear to be more influential. PMID:24858895

The intensive margin of technology adoption--Experimental evidence on improved cooking stoves in rural Senegal.

PubMed

Bensch, Gunther; Peters, Jörg

2015-07-01

Today, almost 3 billion people in developing countries rely on biomass as primary cooking fuel, with profound negative implications for their well-being. Improved biomass cooking stoves are alleged to counteract these adverse effects. This paper evaluates take-up and impacts of low-cost improved stoves through a randomized controlled trial. The randomized stove is primarily designed to curb firewood consumption, but not smoke emissions. Nonetheless, we find considerable effects not only on firewood consumption, but also on smoke exposure and, consequently, smoke-related disease symptoms. The reduced smoke exposure results from behavioural changes in terms of increased outside cooking and a reduction in cooking time. We conclude that in order to assess the effectiveness of a technology-oriented intervention, it is critical to not only account for the incidence of technology adoption - the extensive margin - but also for the way the new technology is used - the intensive margin. Copyright © 2015 Elsevier B.V. All rights reserved.

Multiple outer-reef tracts along the south Florida bank margin: Outlier reefs, a new windward-margin model

USGS Publications Warehouse

Lidz, Barbara H.; Hine, A.C.; Shinn, Eugene A.; Kindinger, Jack G.

1991-01-01

High-resolution seismic-reflection profiles off the lower Florida Keys reveal a multiple outlier-reef tract system ~0.5 to 1.5 km sea-ward of the bank margin. The system is characterized by a massive, outer main reef tract of high (28 m) unburied relief that parallels the margin and at least two narrower, discontinuous reef tracts of lower relief between the main tract and the shallow bank-margin reefs. The outer tract is ~0.5 to 1 km wide and extends a distance of ~57 km. A single pass divides the outer tract into two main reefs. The outlier reefs developed on antecedent, low-gradient to horizontal offbank surfaces, interpreted to be Pleistocene beaches that formed terracelike features. Radiocarbon dates of a coral core from the outer tract confirm a pre-Holocene age. These multiple outlier reefs represent a new windward-margin model that presents a significant, unique mechanism for progradation of carbonate platforms during periods of sea-level fluctuation. Infilling of the back-reef terrace basins would create new terraced promontories and would extend or "step" the platform seaward for hundreds of metres. Subsequent outlier-reef development would produce laterally accumulating sequences.

Structural design/margin assessment

NASA Technical Reports Server (NTRS)

Ryan, R. S.

1993-01-01

Determining structural design inputs and the structural margins following design completion is one of the major activities in space exploration. The end result is a statement of these margins as stability, safety factors on ultimate and yield stresses, fracture limits (fracture control), fatigue lifetime, reuse criteria, operational criteria and procedures, stability factors, deflections, clearance, handling criteria, etc. The process is normally called a load cycle and is time consuming, very complex, and involves much more than structures. The key to successful structural design is the proper implementation of the process. It depends on many factors: leadership and management of the process, adequate analysis and testing tools, data basing, communications, people skills, and training. This process and the various factors involved are discussed.

Passive margin evolution, initiation of subduction and the Wilson cycle

NASA Astrophysics Data System (ADS)

Cloetingh, S. A. P. L.; Wortel, M. J. R.; Vlaar, N. J.

1984-10-01

We have constructed finite element models at various stages of passive margin evolution, in which we have incorporated the system of forces acting on the margin, depth-dependent rheological properties and lateral variations across the margin. We have studied the interrelations between age-dependent forces, geometry and rheology, to decipher their net effect on the state of stress at passive margins. Lithospheric flexure induced by sediment loading dominates the state of stress at passive margins. This study has shown that if after a short evolution of the margin (time span a few tens of million years) subduction has not yet started, continued aging of the passive margin alone does not result in conditions more favourable for transformation into an active margin. Although much geological evidence is available in support of the key role small ocean basins play in orogeny and ophiolite emplacement, evolutionary frameworks of the Wilson cycle usually are cast in terms of opening and closing of wide ocean basins. We propose a more limited role for large oceans in the Wilson cycle concept.

Quantifying disbond area

NASA Astrophysics Data System (ADS)

Lowden, D. W.

1992-10-01

Disbonds simulated in a composite helicopter rotor blade were profiled using eddy currents. The method is inherently accurate and reproducible. An algorithm is described for calculating disbond margin. Disbond area is estimated assuming in-service disbondments exhibit circular geometry.

Worst-Case Flutter Margins from F/A-18 Aircraft Aeroelastic Data

NASA Technical Reports Server (NTRS)

Lind, Rick; Brenner, Marty

1997-01-01

An approach for computing worst-case flutter margins has been formulated in a robust stability framework. Uncertainty operators are included with a linear model to describe modeling errors and flight variations. The structured singular value, micron, computes a stability margin which directly accounts for these uncertainties. This approach introduces a new method of computing flutter margins and an associated new parameter for describing these margins. The micron margins are robust margins which indicate worst-case stability estimates with respect to the defined uncertainty. Worst-case flutter margins are computed for the F/A-18 SRA using uncertainty sets generated by flight data analysis. The robust margins demonstrate flight conditions for flutter may lie closer to the flight envelope than previously estimated by p-k analysis.

A critical theory of medical discourse: how patients and health professionals deal with social problems.

PubMed

Waitzkin, H; Britt, T

1989-01-01

Criticism of social context does not generally appear in medical encounters. When contextual issues arise in medical discourse, messages of ideology and social control may become apparent, usually without the conscious awareness of the participants. By easing the physical or psychological impact of contextual difficulties, or by encouraging patients' conformity to mainstream expectations of desirable behavior, encounters with doctors can help win patients' consent to troubling social conditions. Seen in this light, doctor-patient encounters become micropolitical situations that do not typically encourage explicit statements or actions by health professionals to change contextual sources of their patients' difficulties. A critical theory influenced by structuralism suggests that the surface meanings of signs in medical discourse prove less important than their structural relationships. In addition, a theoretical approach adopting elements of post-structuralism and Marxist literary criticism emphasizes the marginal, absent, or excluded elements of medical discourse. Contextual features that shape a text include social class, sex, age, and race. Through the underlying structure of medical discourse, contextual problems are expressed, marginalized, and managed.

Quantifying construction and demolition waste: an analytical review.

PubMed

Wu, Zezhou; Yu, Ann T W; Shen, Liyin; Liu, Guiwen

2014-09-01

Quantifying construction and demolition (C&D) waste generation is regarded as a prerequisite for the implementation of successful waste management. In literature, various methods have been employed to quantify the C&D waste generation at both regional and project levels. However, an integrated review that systemically describes and analyses all the existing methods has yet to be conducted. To bridge this research gap, an analytical review is conducted. Fifty-seven papers are retrieved based on a set of rigorous procedures. The characteristics of the selected papers are classified according to the following criteria - waste generation activity, estimation level and quantification methodology. Six categories of existing C&D waste quantification methodologies are identified, including site visit method, waste generation rate method, lifetime analysis method, classification system accumulation method, variables modelling method and other particular methods. A critical comparison of the identified methods is given according to their characteristics and implementation constraints. Moreover, a decision tree is proposed for aiding the selection of the most appropriate quantification method in different scenarios. Based on the analytical review, limitations of previous studies and recommendations of potential future research directions are further suggested. Copyright © 2014 Elsevier Ltd. All rights reserved.

Single-Center Experience Using Marginal Liver Grafts in Korea.

PubMed

Park, P-J; Yu, Y-D; Yoon, Y-I; Kim, S-R; Kim, D-S

2018-05-01

Liver transplantation (LT) is an established therapeutic modality for patients with end-stage liver disease. The use of marginal donors has become more common worldwide due to the sharp increase in recipients, with a consequent shortage of suitable organs. We analyzed our single-center experience over the last 8 years in LT to evaluate the outcomes of using so-called "marginal donors." We retrospectively analyzed the database of all LTs performed at our institution from 2009 to 2017. Only patients undergoing deceased-donor LTs were analyzed. Marginal grafts were defined as livers from donors >60 years of age, livers from donors with serum sodium levels >155 mEq, graft steatosis >30%, livers with cold ischemia time ≥12 hours, livers from donors who were hepatitis B or C virus positive, livers recovered from donation after cardiac death, and livers split between 2 recipients. Patients receiving marginal grafts (marginal group) were compared with patients receiving standard grafts (standard group). A total of 106 patients underwent deceased-donor LT. There were 55 patients in the standard group and 51 patients in the marginal group. There were no significant differences in terms of age, sex, Model for End-Stage Liver Disease score, underlying liver disease, presence of hepatocellular carcinoma, and hospital stay between the 2 groups. Although the incidence of acute cellular rejection, cytomegalovirus infection, and postoperative complications was similar between the 2 groups, the incidence of early allograft dysfunction was higher in the marginal group. With a median follow-up of 26 months, the 1-, 3-, and 5-year overall and graft (death-censored) survivals in the marginal group were 85.5%, 75%, and 69.2% and 85.9%, 83.6%, and 77.2%, respectively. Patient overall survival and graft survival (death-censored) were significantly lower in the marginal group (P = .023 and P = .048, respectively). On multivariate analysis, receiving a marginal graft (hazard ratio [HR

Conduit margin heating and deformation during the AD 1886 basaltic Plinian eruption at Tarawera volcano, New Zealand.

PubMed

Schauroth, Jenny; Wadsworth, Fabian B; Kennedy, Ben; von Aulock, Felix W; Lavallée, Yan; Damby, David E; Vasseur, Jérémie; Scheu, Bettina; Dingwell, Donald B

During explosive eruptions, a suspension of gas and pyroclasts rises rapidly within a conduit. Here, we have analysed textures preserved in the walls of a pyroclastic feeder dyke of the AD 1886 Tarawera basaltic Plinian fissure eruption. The samples examined consist of basaltic ash and scoria plastered onto a conduit wall of a coherent rhyolite dome and a welded rhyolitic dome breccia. We examine the textural evidence for the response of the wall material, built of ∼75 vol.% glass and ∼25 vol.% crystals (pore-free equivalent), to mass movement in the adjacent conduit. In the rhyolitic wall material, we quantify the orientation and aspect ratio of biotite crystals as strain markers of simple shear deformation, and interpret juxtaposed regions of vesiculation and vesicle collapse as evidence of conduit wall heating. Systematic changes occur close to the margin: (1) porosity is highly variable, with areas locally vesiculated or densified, (2) biotite crystals are oriented with their long axis parallel to the margin, (3) the biotites have greater aspect ratios close to the margin and (4) the biotite crystals are fractured. We interpret the biotite phenocryst deformation to result from crystal fracture, rotation and cleavage-parallel bookcase translation. These textural observations are inferred to indicate mechanical coupling between the hot gas-ash jet and the conduit wall and reheating of wall rock rhyolite. We couple these observations with a simple 1D conductive heating model to show what minimum temperature the conduit wall needs to reach in order to achieve a temperature above the glass transition throughout the texturally-defined deformed zone. We propose that conduit wall heating and resulting deformation influences conduit margin outgassing and may enhance the intensity of such large basaltic eruptions.

Remote sensing of the marginal ice zone during Marginal Ice Zone Experiment (MIZEX) 83

NASA Technical Reports Server (NTRS)

Shuchman, R. A.; Campbell, W. J.; Burns, B. A.; Ellingsen, E.; Farrelly, B. A.; Gloersen, P.; Grenfell, T. C.; Hollinger, J.; Horn, D.; Johannessen, J. A.

1984-01-01

The remote sensing techniques utilized in the Marginal Ice Zone Experiment (MIZEX) to study the physical characteristics and geophysical processes of the Fram Strait Region of the Greenland Sea are described. The studies, which utilized satellites, aircraft, helicopters, and ship and ground-based remote sensors, focused on the use of microwave remote sensors. Results indicate that remote sensors can provide marginal ice zone characteristics which include ice edge and ice boundary locations, ice types and concentration, ice deformation, ice kinematics, gravity waves and swell (in the water and the ice), location of internal wave fields, location of eddies and current boundaries, surface currents and sea surface winds.

Exploring the Subtleties of Inverse Probability Weighting and Marginal Structural Models.

PubMed

Breskin, Alexander; Cole, Stephen R; Westreich, Daniel

2018-05-01

Since being introduced to epidemiology in 2000, marginal structural models have become a commonly used method for causal inference in a wide range of epidemiologic settings. In this brief report, we aim to explore three subtleties of marginal structural models. First, we distinguish marginal structural models from the inverse probability weighting estimator, and we emphasize that marginal structural models are not only for longitudinal exposures. Second, we explore the meaning of the word "marginal" in "marginal structural model." Finally, we show that the specification of a marginal structural model can have important implications for the interpretation of its parameters. Each of these concepts have important implications for the use and understanding of marginal structural models, and thus providing detailed explanations of them may lead to better practices for the field of epidemiology.

Scheduling Real-Time Mixed-Criticality Jobs

NASA Astrophysics Data System (ADS)

Baruah, Sanjoy K.; Bonifaci, Vincenzo; D'Angelo, Gianlorenzo; Li, Haohan; Marchetti-Spaccamela, Alberto; Megow, Nicole; Stougie, Leen

Many safety-critical embedded systems are subject to certification requirements; some systems may be required to meet multiple sets of certification requirements, from different certification authorities. Certification requirements in such "mixed-criticality" systems give rise to interesting scheduling problems, that cannot be satisfactorily addressed using techniques from conventional scheduling theory. In this paper, we study a formal model for representing such mixed-criticality workloads. We demonstrate first the intractability of determining whether a system specified in this model can be scheduled to meet all its certification requirements, even for systems subject to two sets of certification requirements. Then we quantify, via the metric of processor speedup factor, the effectiveness of two techniques, reservation-based scheduling and priority-based scheduling, that are widely used in scheduling such mixed-criticality systems, showing that the latter of the two is superior to the former. We also show that the speedup factors are tight for these two techniques.

Participation, Financial Support and the Marginal Student

ERIC Educational Resources Information Center

Davies, Peter; Mangan, Jean; Hughes, Amanda

2009-01-01

This paper examines differences between the decision-making of marginal and nonmarginal students about participation in higher education (HE). We distinguish between two kinds of marginality: being "borderline" on account of prior achievements in school and being "unsure" after taking prior achievement into account. We identify a significant…

Quantifying the underlying landscape and paths of cancer

PubMed Central

Li, Chunhe; Wang, Jin

2014-01-01

Cancer is a disease regulated by the underlying gene networks. The emergence of normal and cancer states as well as the transformation between them can be thought of as a result of the gene network interactions and associated changes. We developed a global potential landscape and path framework to quantify cancer and associated processes. We constructed a cancer gene regulatory network based on the experimental evidences and uncovered the underlying landscape. The resulting tristable landscape characterizes important biological states: normal, cancer and apoptosis. The landscape topography in terms of barrier heights between stable state attractors quantifies the global stability of the cancer network system. We propose two mechanisms of cancerization: one is by the changes of landscape topography through the changes in regulation strengths of the gene networks. The other is by the fluctuations that help the system to go over the critical barrier at fixed landscape topography. The kinetic paths from least action principle quantify the transition processes among normal state, cancer state and apoptosis state. The kinetic rates provide the quantification of transition speeds among normal, cancer and apoptosis attractors. By the global sensitivity analysis of the gene network parameters on the landscape topography, we uncovered some key gene regulations determining the transitions between cancer and normal states. This can be used to guide the design of new anti-cancer tactics, through cocktail strategy of targeting multiple key regulation links simultaneously, for preventing cancer occurrence or transforming the early cancer state back to normal state. PMID:25232051

Marginalizing Women: Images of Pregnancy in Williams Obstetrics

PubMed Central

Smith, Sheila A.; Condit, Deirdre M.

2000-01-01

This research analyzes the historical development of the medical construction of the pregnant body in 17 of 20 editions of Williams Obstetrics, an obstetrical textbook published continually from 1904 to 1997. Examination of the visual imagery of these works produced three key findings. First, depictions of the healthy or “normal” pregnant body are virtually absent throughout the series. Second, visual depictions of women's full bodies adhere to a race-based hierarchy of presentation. Finally, the fundamental discourse about pregnant and female bodies communicated to physicians (primarily) by these images is one of pathology and fragmentation. We conclude that the resulting social and medical construction of the pregnant and female body presented in the Williams series is one of disembodiment, abjection, and ultimately marginality. These findings support recent feminist research that criticizes both the increasing erasure of the person of the women from the medical interpretation of pregnancy and the concomitant decrease in women's perceived sense of empowerment as pregnant beings. PMID:17273202

Bayesian focalization: quantifying source localization with environmental uncertainty.

PubMed

Dosso, Stan E; Wilmut, Michael J

2007-05-01

This paper applies a Bayesian formulation to study ocean acoustic source localization as a function of uncertainty in environmental properties (water column and seabed) and of data information content [signal-to-noise ratio (SNR) and number of frequencies]. The approach follows that of the optimum uncertain field processor [A. M. Richardson and L. W. Nolte, J. Acoust. Soc. Am. 89, 2280-2284 (1991)], in that localization uncertainty is quantified by joint marginal probability distributions for source range and depth integrated over uncertain environmental properties. The integration is carried out here using Metropolis Gibbs' sampling for environmental parameters and heat-bath Gibbs' sampling for source location to provide efficient sampling over complicated parameter spaces. The approach is applied to acoustic data from a shallow-water site in the Mediterranean Sea where previous geoacoustic studies have been carried out. It is found that reliable localization requires a sufficient combination of prior (environmental) information and data information. For example, sources can be localized reliably for single-frequency data at low SNR (-3 dB) only with small environmental uncertainties, whereas successful localization with large environmental uncertainties requires higher SNR and/or multifrequency data.

Quantifying the direct use value of Condor seamount

NASA Astrophysics Data System (ADS)

Ressurreição, Adriana; Giacomello, Eva

2013-12-01

Seamounts often satisfy numerous uses and interests. Multiple uses can generate multiple benefits but also conflicts and impacts, calling, therefore, for integrated and sustainable management. To assist in developing comprehensive management strategies, policymakers recognise the need to include measures of socioeconomic analysis alongside ecological data so that practical compromises can be made. This study assessed the direct output impact (DOI) of the relevant marine activities operating at Condor seamount (Azores, central northeast Atlantic) as proxies of the direct use values provided by the resource system. Results demonstrated that Condor seamount supported a wide range of uses yielding distinct economic outputs. Demersal fisheries, scientific research and shark diving were the top-three activities generating the highest revenues, while tuna fisheries, whale watching and scuba-diving had marginal economic significance. Results also indicated that the economic importance of non-extractive uses of Condor is considerable, highlighting the importance of these uses as alternative income-generating opportunities for local communities. It is hoped that quantifying the direct use values provided by Condor seamount will contribute to the decision making process towards its long-term conservation and sustainable use.

Neural basis for generalized quantifier comprehension.

PubMed

McMillan, Corey T; Clark, Robin; Moore, Peachie; Devita, Christian; Grossman, Murray

2005-01-01

Generalized quantifiers like "all cars" are semantically well understood, yet we know little about their neural representation. Our model of quantifier processing includes a numerosity device, operations that combine number elements and working memory. Semantic theory posits two types of quantifiers: first-order quantifiers identify a number state (e.g. "at least 3") and higher-order quantifiers additionally require maintaining a number state actively in working memory for comparison with another state (e.g. "less than half"). We used BOLD fMRI to test the hypothesis that all quantifiers recruit inferior parietal cortex associated with numerosity, while only higher-order quantifiers recruit prefrontal cortex associated with executive resources like working memory. Our findings showed that first-order and higher-order quantifiers both recruit right inferior parietal cortex, suggesting that a numerosity component contributes to quantifier comprehension. Moreover, only probes of higher-order quantifiers recruited right dorsolateral prefrontal cortex, suggesting involvement of executive resources like working memory. We also observed activation of thalamus and anterior cingulate that may be associated with selective attention. Our findings are consistent with a large-scale neural network centered in frontal and parietal cortex that supports comprehension of generalized quantifiers.

A Critical Politics of Knowledge: Analyzing the Role of Educational Psychology in Educational Policy

ERIC Educational Resources Information Center

Kincheloe, Joe L.

2006-01-01

This article examines the ideological dimensions of educational psychology and psychometrics as they relate to the validation of the "intelligence" of the privileged and the "deficiency" of the marginalized. In this critique a critical psychology emerges that takes seriously the lifeworld experiences of culturally and…

'Marginal' BY Draconis stars

NASA Technical Reports Server (NTRS)

Bopp, Bernard W.

1987-01-01

Spectroscopic observations of 52 dK-dM stars, obtained at 640-665 nm (with spectral resolution 70-90 pm) using CCD detectors on the coude-feed telescope at KPNO since 1982, are reported. Data for four stars found to have diluted absorption or weak emission above continuum at H-alpha are presented in tables and spectra and discussed in detail. These objects (Gliese numbers 256, 425A, 900, and 907.1) are shown to be 'marginal' BY Dra stars, single objects of age 2.5-3 Gyr with activity and rotational velocity (3-5 km/s) between those of normal dM stars and those of true BY Dra stars. An explanation based on evolution from the BY Dra stage through marginal BY Dra to inactive dM is proposed.

Applied Time Domain Stability Margin Assessment for Nonlinear Time-Varying Systems

NASA Technical Reports Server (NTRS)

Kiefer, J. M.; Johnson, M. D.; Wall, J. H.; Dominguez, A.

2016-01-01

The baseline stability margins for NASA's Space Launch System (SLS) launch vehicle were generated via the classical approach of linearizing the system equations of motion and determining the gain and phase margins from the resulting frequency domain model. To improve the fidelity of the classical methods, the linear frequency domain approach can be extended by replacing static, memoryless nonlinearities with describing functions. This technique, however, does not address the time varying nature of the dynamics of a launch vehicle in flight. An alternative technique for the evaluation of the stability of the nonlinear launch vehicle dynamics along its trajectory is to incrementally adjust the gain and/or time delay in the time domain simulation until the system exhibits unstable behavior. This technique has the added benefit of providing a direct comparison between the time domain and frequency domain tools in support of simulation validation. This technique was implemented by using the Stability Aerospace Vehicle Analysis Tool (SAVANT) computer simulation to evaluate the stability of the SLS system with the Adaptive Augmenting Control (AAC) active and inactive along its ascent trajectory. The gains for which the vehicle maintains apparent time-domain stability defines the gain margins, and the time delay similarly defines the phase margin. This method of extracting the control stability margins from the time-domain simulation is relatively straightforward and the resultant margins can be compared to the linearized system results. The sections herein describe the techniques employed to extract the time-domain margins, compare the results between these nonlinear and the linear methods, and provide explanations for observed discrepancies. The SLS ascent trajectory was simulated with SAVANT and the classical linear stability margins were evaluated at one second intervals. The linear analysis was performed with the AAC algorithm disabled to attain baseline stability

Realistic respiratory motion margins for external beam partial breast irradiation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Conroy, Leigh; Quirk, Sarah; Department of Physics and Astronomy, University of Calgary, Calgary, Alberta T2N 1N4

Purpose: Respiratory margins for partial breast irradiation (PBI) have been largely based on geometric observations, which may overestimate the margin required for dosimetric coverage. In this study, dosimetric population-based respiratory margins and margin formulas for external beam partial breast irradiation are determined. Methods: Volunteer respiratory data and anterior–posterior (AP) dose profiles from clinical treatment plans of 28 3D conformal radiotherapy (3DCRT) PBI patient plans were used to determine population-based respiratory margins. The peak-to-peak amplitudes (A) of realistic respiratory motion data from healthy volunteers were scaled from A = 1 to 10 mm to create respiratory motion probability density functions. Dosemore » profiles were convolved with the respiratory probability density functions to produce blurred dose profiles accounting for respiratory motion. The required margins were found by measuring the distance between the simulated treatment and original dose profiles at the 95% isodose level. Results: The symmetric dosimetric respiratory margins to cover 90%, 95%, and 100% of the simulated treatment population were 1.5, 2, and 4 mm, respectively. With patient set up at end exhale, the required margins were larger in the anterior direction than the posterior. For respiratory amplitudes less than 5 mm, the population-based margins can be expressed as a fraction of the extent of respiratory motion. The derived formulas in the anterior/posterior directions for 90%, 95%, and 100% simulated population coverage were 0.45A/0.25A, 0.50A/0.30A, and 0.70A/0.40A. The differences in formulas for different population coverage criteria demonstrate that respiratory trace shape and baseline drift characteristics affect individual respiratory margins even for the same average peak-to-peak amplitude. Conclusions: A methodology for determining population-based respiratory margins using real respiratory motion patterns and dose profiles in the AP

17 CFR 41.47 - Withdrawal of margin.

Code of Federal Regulations, 2010 CFR

2010-04-01

... PRODUCTS Customer Accounts and Margin Requirements § 41.47 Withdrawal of margin. (a) By the customer... positions in the account under this Regulation (Subpart E, §§ 41.42 through 41.49). (b) By the security...) Interest charged on credit maintained in the account; (3) Communication or shipping charges with respect to...

The crustal structure of the southern Argentine margin

NASA Astrophysics Data System (ADS)

Becker, Katharina; Franke, Dieter; Schnabel, Michael; Schreckenberger, Bernd; Heyde, Ingo; Krawczyk, Charlotte M.

2012-06-01

Multichannel reflection seismic profiles, combined with gravimetric and magnetic data provide insight into the crustal structure of the southernmost Argentine margin, at the transition from a rifted to a transform margin and outline the extent of the North Falkland Graben. Based on these data, we establish a regional stratigraphic model for the post-rift sediments, comprising six marker horizons with a new formation in the Barremian/Lower Cretaceous. Our observations support that a N-S trending subsidiary branch of the North Falkland Graben continues along the continental shelf and slope to the Argentine basin. During the rift phase, a wide shelf area was affected by the E-W extension, subsequently forming the North Falkland Graben and the subsidiary branch along which finally breakup occurred. We propose the division of the margin in two segments: a N-S trending rifted margin and an E-W trending transform margin. This is further underpinned by crustal scale gravity modelling. Three different tectono-dynamic processes shaped the study area. (1) The Triassic/Early Jurassic extensional phase resulting in the formation of the North Falkland Graben and additional narrower rift grabens ended synchronously with the breakup of the South Atlantic in the early Valanginian. (2) Extensional phase related to the opening of the South Atlantic. (3) The transform margin was active in the study area from about Hauterivian times and activity lasted until late Cretaceous/early Cenozoic. Both, the rifted margin and the transform margin are magma-poor. Very limited structures may have a volcanic origin but are suggested to be post-rift. The oceanic crust was found to be unusually thin, indicating a deficit in magma supply during formation. These findings in combination with the proposed breakup age in the early Valanginian that considerably predates the formation of the Paraná-Etendeka continental flood basalt provinces in Brazil and Namibia question the influence of the Tristan da

Catastrophic Bleeding From a Marginal Ulcer After Gastric Bypass

PubMed Central

Sidani, Shafik; Akkary, Ehab

2013-01-01

Marginal ulceration at the gastrojejunal anastomosis is a common complication following Roux-Y gastric bypass (RYGB). Hemodynamically significant hemorrhagic marginal ulcers are usually treated either endoscopically or surgically. We describe a unique case of life-threatening hemorrhagic marginal ulcer eroding into the main splenic artery. This condition was initially managed with angiographic embolization, followed by surgical intervention. PMID:23743389

Quantifiable Assessment of SWNT Dispersion in Polymer Composites

NASA Technical Reports Server (NTRS)

Park, Cheol; Kim, Jae-Woo; Wise, Kristopher E.; Working, Dennis; Siochi, Mia; Harrison, Joycelyn; Gibbons, Luke; Siochi, Emilie J.; Lillehei, Peter T.; Cantrell, Sean;

Holocene Paleoceanographic Environments at the Chukchi-Alaskan Margin: Implications for Future Changes

NASA Astrophysics Data System (ADS)

Polyak, L.; Nam, S. I.; Dipre, G.; Kim, S. Y.; Ortiz, J. D.; Darby, D. A.

2017-12-01

The impacts of the North Pacific oceanic and atmospheric system on the Arctic Ocean result in accelerated sea-ice retreat and related changes in hydrography and biota in the western Arctic. Paleoclimatic records from the Pacific sector of the Arctic are key for understanding the long-term history of these interactions. As opposed to stratigraphically long but strongly compressed sediment cores recovered from the deep Arctic Ocean, sediment depocenters on the Chukchi-Alaskan margin yield continuous, medium to high resolution records formed since the last deglaciation. While early Holocene conditions were non-analogous to modern environments due to the effects of prolonged deglaciation and insufficiently high sea levels, mid to late Holocene sediments are more relevant for recent and modern climate variability. Notably, a large depocenter at the Alaskan margin has sedimentation rates estimated as high as a few millimeters per year, thus providing a decadal to near-annual resolution. This high accumulation can be explained by sediment delivery via the Alaskan Coastal Current originating from the Bering Sea and supposedly controlled by the Aleutian Low pressure center. Preliminary results from sediment cores recovering the last several centuries, along with a comparison with other paleoclimatic proxy records from the Arctic-North Pacific region, indicate a persistent role of the Aleutian Low in the Bering Strait inflow and attendant deposition. More proxy studies are underway to reconstruct the history of this circulation system and its relationship with sea ice extent. The expected results will improve our understanding of natural variability in oceanic and atmospheric conditions at the Chukchi-Alaskan margin, a critical area for modulating the Arctic climate change.

Time Safety Margin: Theory and Practice

DTIC Science & Technology

2016-09-01

Basic Dive Recovery Terminology The Simplest Definition of TSM: Time Safety Margin is the time to directly travel from the worst-case vector to an...Safety Margin (TSM). TSM is defined as the time in seconds to directly travel from the worst case vector (i.e. worst case combination of parameters...invoked by this AFI, base recovery planning and risk management upon the calculated TSM. TSM is the time in seconds to di- rectly travel from the worst case

Gas hydrates of outer continental margins

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kvenvolden, K.A.

1990-05-01

Gas hydrates are crystalline substances in which a rigid framework of water molecules traps molecules of gas, mainly methane. Gas-hydrate deposits are common in continental margin sediment in all major oceans at water depths greater than about 300 m. Thirty-three localities with evidence for gas-hydrate occurrence have been described worldwide. The presence of these gas hydrates has been inferred mainly from anomalous lacoustic reflectors seen on marine seismic records. Naturally occurring marine gas hydrates have been sampled and analyzed at about tensites in several regions including continental slope and rise sediment of the eastern Pacific Ocean and the Gulf ofmore » Mexico. Except for some Gulf of Mexico gas hydrate occurrences, the analyzed gas hydrates are composed almost exclusively of microbial methane. Evidence for the microbial origin of methane in gas hydrates includes (1) the inverse relation between methane occurence and sulfate concentration in the sediment, (2) the subparallel depth trends in carbon isotopic compositions of methane and bicarbonate in the interstitial water, and (3) the general range of {sup 13}C depletion ({delta}{sub PDB}{sup 13}C = {minus}90 to {minus}60 {per thousand}) in the methane. Analyses of gas hydrates from the Peruvian outer continental margin in particular illustrate this evidence for microbially generated methane. The total amount of methane in gas hydrates of continental margins is not known, but estimates of about 10{sup 16} m{sup 3} seem reasonable. Although this amount of methane is large, it is not yet clear whether methane hydrates of outer continental margins will ever be a significant energy resource; however, these gas hydrates will probably constitute a drilling hazard when outer continental margins are explored in the future.« less

Critical Hip-Hop Language Pedagogies: Combat, Consciousness, and the Cultural Politics of Communication

ERIC Educational Resources Information Center

Alim, H. Samy

2007-01-01

This article addresses two long-standing tensions in the education of linguistically marginalized youth: (a) the cultural tension, or cultural combat, that such students engage in as they form their linguistic identities, and (b) the tensions between the development of critical language pedagogies and the lack of their broader implementation due…

30 CFR 204.3 - What alternatives are available for marginal properties?

Code of Federal Regulations, 2010 CFR

2010-07-01

... 30 Mineral Resources 2 2010-07-01 2010-07-01 false What alternatives are available for marginal... MINERALS REVENUE MANAGEMENT ALTERNATIVES FOR MARGINAL PROPERTIES General Provisions § 204.3 What alternatives are available for marginal properties? If you have production from a marginal property, MMS and...

Margination of Stiffened Red Blood Cells Regulated By Vessel Geometry.

PubMed

Chen, Yuanyuan; Li, Donghai; Li, Yongjian; Wan, Jiandi; Li, Jiang; Chen, Haosheng

2017-11-10

Margination of stiffened red blood cells has been implicated in many vascular diseases. Here, we report the margination of stiffened RBCs in vivo, and reveal the crucial role of the vessel geometry in the margination by calculations when the blood is seen as viscoelastic fluid. The vessel-geometry-regulated margination is then confirmed by in vitro experiments in microfluidic devices, and it establishes new insights to cell sorting technology and artificial blood vessel fabrication.

Post-breakup faulting of the outer Vøring Margin

NASA Astrophysics Data System (ADS)

Planke, S.; Millett, J.; Jerram, D. A.; Maharjan, D.; Hafeez, A.; Abdelmalak, M. M.; Zastrozhnov, D.; Faleide, J. I.

2017-12-01

Tectonic activity on passive margins may continue for a long time after the main phase of continental breakup. On the southern Vøring Margin, offshore Norway, new high-quality 3D seismic data reveal the presence of extensive normal faults offsetting the Top basalt horizon, along with overlying lower Eocene age sediments. We have completed a detailed seismic interpretation of the new data using a combination of conventional seismic horizon interpretation and igneous seismic geomorphological techniques. The seismic data have been tied to scientific and industry wells to constrain the age of the interpreted horizons and the age and duration of the faulting. The Top basalt horizon displays a dominantly subaerial lava field, on the Vøring Marginal High, with well-defined lava flow morphologies including inflated flow lobes and surface pressure ridges. The prominent kilometer-high Vøring Escarpment was developed when landward flowing lava met the ocean, developing an extensive foreset bedded hyaloclastite delta. Later, a pitted surface was developed in the west during lava emplacement in a wet environment during subsidence of the central rift valley. Earliest Eocene sediments were subsequently deposited on the marginal high. Well-defined northeast trending faults are imaged on the marginal high, cutting across the escarpment. Spacing of the faults is ca. 400-500 m, and offsets are typically of ca. 30-50 m, often defining graben structures. The faults further offset the overlying earliest Eocene sequences in a number of examples. Based on the well ties, faulting mainly took place 5-10 m.y. after continental breakup near the Paleocene-Eocene boundary. Our hypothesis is that the faulting is related to strain partitioning across the developing Vøring Transform Margin. Plate tectonic constraints show that there was an active continent-continent transform in this region also for 10-15 m.y. after breakup. The transform margin is a linear, northwest trending structure, with

Critical Race Theory, Race Equity, and Public Health: Toward Antiracism Praxis

PubMed Central

Airhihenbuwa, Collins O.

2010-01-01

Racial scholars argue that racism produces rates of morbidity, mortality, and overall well-being that vary depending on socially assigned race. Eliminating racism is therefore central to achieving health equity, but this requires new paradigms that are responsive to structural racism's contemporary influence on health, health inequities, and research. Critical Race Theory is an emerging transdisciplinary, race-equity methodology that originated in legal studies and is grounded in social justice. Critical Race Theory's tools for conducting research and practice are intended to elucidate contemporary racial phenomena, expand the vocabulary with which to discuss complex racial concepts, and challenge racial hierarchies. We introduce Critical Race Theory to the public health community, highlight key Critical Race Theory characteristics (race consciousness, emphases on contemporary societal dynamics and socially marginalized groups, and praxis between research and practice) and describe Critical Race Theory's contribution to a study on racism and HIV testing among African Americans. PMID:20147679

In vitro marginal fit of three all-ceramic crown systems.

PubMed

Yeo, In-Sung; Yang, Jae-Ho; Lee, Jai-Bong

2003-11-01

Studies on marginal discrepancies of single restorations using various systems and materials have resulted in statistical inferences that are ambiguous because of small sample sizes and limited numbers of measurements per specimen. The purpose of this study was to compare the marginal adaptation of single anterior restorations made using different systems. The in vitro marginal discrepancies of 3 different all-ceramic crown systems (Celay In-Ceram, conventional In-Ceram, and IPS Empress 2 layering technique), and a control group of metal ceramic restorations were evaluated and compared by measuring the gap dimension between the crowns and the prepared tooth at the marginal opening. The crowns were made for 1 extracted maxillary central incisor prepared with a 1-mm shoulder margin and 6-degree tapered walls by milling. Thirty crowns per system were fabricated. Crown measurements were recorded with an optical microscope, with an accuracy of +/-0.1 microm, at 50 points spaced approximately 400 microm along the circumferential margin. The criterion of 120 microm was used as the maximum clinically acceptable marginal gap. Mean gap dimensions and standard deviations were calculated for marginal opening. The data were analyzed with a 1-way analysis of variance (alpha=.05). Mean gap dimensions and standard deviations at the marginal opening for the incisor crowns were 87 +/- 34 microm for control, 83 +/- 33 microm for Celay In-Ceram, 112 +/- 55 microm for conventional In-Ceram, and 46 +/- 16 microm for the IPS Empress 2 layering technique. Significant differences were found among the crown groups (P<.05). Compared with the control group, the IPS Empress 2 group had significantly smaller marginal discrepancies (P<.05), and the conventional In-Ceram group exhibited significantly greater marginal discrepancies (P<.05). There was no significant difference between the Celay In-Ceram and the control group. Within the limitations of this study, the marginal discrepancies were all

Identifying technology innovations for marginalized smallholders-A conceptual approach.

PubMed

Malek, Mohammad Abdul; Gatzweiler, Franz W; Von Braun, Joachim

2017-05-01

This paper adds a contribution in the existing literature in terms of theoretical and conceptual background for the identification of idle potentials of marginal rural areas and people by means of technological and institutional innovations. The approach follows ex-ante assessment for identifying suitable technology and institutional innovations for marginalized smallholders in marginal areas-divided into three main parts (mapping, surveying and evaluating) and several steps. Finally, it contributes to the inclusion of marginalized smallholders by an improved way of understanding the interactions between technology needs, farming systems, ecological resources and poverty characteristics in the different segments of the poor, and to link these insights with productivity enhancing technologies.

SOME IS NOT ENOUGH: QUANTIFIER COMPREHENSION IN CORTICOBASAL SYNDROME AND BEHAVIORAL VARIANT FRONTOTEMPORAL DEMENTIA

PubMed Central

Morgan, Brianna; Gross, Rachel; Clark, Robin; Dreyfuss, Michael; Boller, Ashley; Camp, Emily; Liang, Tsao-Wei; Avants, Brian; McMillan, Corey; Grossman, Murray

2011-01-01

Quantifiers are very common in everyday speech, but we know little about their cognitive basis or neural representation. The present study examined comprehension of three classes of quantifiers that depend on different cognitive components in patients with focal neurodegenerative diseases. Patients evaluated the truth-value of a sentence containing a quantifier relative to a picture illustrating a small number of familiar objects, and performance was related to MRI grey matter atrophy using voxel-based morphometry. We found that patients with corticobasal syndrome (CBS) and posterior cortical atrophy (PCA) are significantly impaired in their comprehension of Cardinal Quantifiers (e.g. “At least three birds are on the branch”), due in part to their deficit in quantity knowledge. MRI analyses related this deficit to temporal-parietal atrophy found in CBS/PCA. We also found that patients with behavioral variant frontotemporal dementia (bvFTD) are significantly impaired in their comprehension of Logical Quantifiers (e.g. “Some the birds are on the branch”), associated with a simple form of perceptual logic, and this correlated with their deficit on executive measures. This deficit was related to disease in rostral prefrontal cortex in bvFTD. These patients were also impaired in their comprehension of Majority Quantifiers (e.g. “At least half of the birds are on the branch”), and this too was correlated with their deficit on executive measures. This was related to disease in the basal ganglia interrupting a frontal-striatal loop critical for executive functioning. These findings suggest that a large-scale frontal-parietal neural network plays a crucial role in quantifier comprehension, and that comprehension of specific classes of quantifiers may be selectively impaired in patients with focal neurodegenerative conditions in these areas. PMID:21930136

Analysis of System Margins on Missions Utilizing Solar Electric Propulsion

NASA Technical Reports Server (NTRS)

Oh, David Y.; Landau, Damon; Randolph, Thomas; Timmerman, Paul; Chase, James; Sims, Jon; Kowalkowski, Theresa

2008-01-01

NASA's Jet Propulsion Laboratory has conducted a study focused on the analysis of appropriate margins for deep space missions using solar electric propulsion (SEP). The purpose of this study is to understand the links between disparate system margins (power, mass, thermal, etc.) and their impact on overall mission performance and robustness. It is determined that the various sources of uncertainty and risk associated with electric propulsion mission design can be summarized into three relatively independent parameters 1) EP Power Margin, 2) Propellant Margin and 3) Duty Cycle Margin. The overall relationship between these parameters and other major sources of uncertainty is presented. A detailed trajectory analysis is conducted to examine the impact that various assumptions related to power, duty cycle, destination, and thruster performance including missed thrust periods have on overall performance. Recommendations are presented for system margins for deep space missions utilizing solar electric propulsion.

Ins and outs of a complex subduction zone: C cycling along the Sunda margin, Indonesia

NASA Astrophysics Data System (ADS)

House, B. M.; Bebout, G. E.; Hilton, D. R.

2016-12-01

Subduction of C in marine sediments and altered oceanic crust is the main mechanism for reintroducing C into the deep earth and removing it from communication with the ocean and atmosphere. However, detailed studies of individual margins - which are necessary to understanding global C cycling - are sparse. The thick, C-rich sediment column along the Sunda margin, Indonesia makes understanding this margin crucial for constructing global C cycling budgets. Furthermore it is an ideal location to compare cycling of organic and carbonate C due to the abrupt transition from carbonate-dominated sediments in the SE to sediments rich in organic C from the Nicobar Fan in the NW. To quantify and characterize C available for subduction, we analyzed samples from DSDP 211, 260, 261, and ODP 765, all outboard of the trench, as well as piston and gravity cores of locally-sourced terrigenous trench fill. We created a 3-D model of overall sediment thickness and the thicknesses of geochemically distinct sedimentary units using archived and published seismic profiles to infer unit thicknesses at and along the 2500 km trench. This model vastly improves estimates of the C available for subduction and also reveals that the Christmas Island Seamount Province serves as a barrier to turbidite flow, dividing the regions of the trench dominated by organic and inorganic C input. Incorporating best estimates for the depth of the decollement indicates that the terrigenous trench fill, with up to 1.5 wt % organic C, is entirely accreted as is the thick section of carbonate-rich turbidites that dominate the southeastern portion of the margin (DSDP 261/ODP 765). Organic C accounts for most of the C bypassing the accretionary complex NW of the Christmas Island Seamount Province, and C inputs to the trench are lower there than to the SE where carbonate units near the base of the sediment column are the dominant C source. Release of C from altered oceanic crust - a C reservoir up to 10 times greater

Measuring Institutional Quality in Head and Neck Surgery Using Hospital-Level Data: Negative Margin Rates and Neck Dissection Yield.

PubMed

Schoppy, David W; Rhoads, Kim F; Ma, Yifei; Chen, Michelle M; Nussenbaum, Brian; Orosco, Ryan K; Rosenthal, Eben L; Divi, Vasu

2017-11-01

Negative margins and lymph node yields (LNY) of 18 or more from neck dissections in patients with head and neck squamous cell carcinomas (HNSCC) have been associated with improved patient survival. It is unclear whether these metrics can be used to identify hospitals with improved outcomes. To determine whether 2 patient-level metrics would predict outcomes at the hospital level. A retrospective review of records from the National Cancer Database (NCDB) was used to identify patients who underwent primary surgery and concurrent neck dissection for HNSCC between 2004 and 2013. The percentage of patients at each hospital with negative margins on primary resection and an LNY 18 or more from a neck dissection was quantified. Cox proportional hazard models were used to define the association between hospital performance on these metrics and overall survival. Margin status and lymph node yield at hospital level. Overall survival (OS). We identified 1008 hospitals in the NCDB where 64 738 patients met inclusion criteria. Of the 64 738 participants, 45 170 (69.8%) were men and 19 568 (30.2%) were women. The mean SD age of included patients was 60.5 (12.0) years. Patients treated at hospitals attaining the combined metric of a 90% or higher negative margin rate and 80% or more of cases with LNYs of 18 or more experienced a significant reduction in mortality (hazard ratio [HR] 0.93; 95% CI, 0.89-0.98). This benefit in survival was independent of the patient-level improvement associated with negative margins (HR, 0.73; 95% CI, 0.71-0.76) and LNY of 18 or more (HR, 0.85; 95% CI, 0.83-0.88). Including these metrics in the model neutralized the association of traditional measures of hospital quality (volume and teaching status). Treatment at hospitals that attain a high rate of negative margins and LNY of 18 or more is associated with improved survival in patients undergoing surgery for HNSCC. These surgical outcome measures predicted outcomes independent of traditional

Unconditionally marginal stability of harmonic electron hole equilibria in current-driven plasmas

NASA Astrophysics Data System (ADS)

Schamel, Hans

2018-06-01

Two forms of the linearized eigenvalue problem with respect to linear perturbations of a privileged cnoidal electron hole as a structural nonlinear equilibrium element are established. Whereas its integral form involves integrations along the characteristics or unperturbed particle orbits, the differential form has to cope with a differential operator of infinite order. Both are hence faced with difficulties to obtain a solution. A first successful attempt is, however, made by addressing a single harmonic wave as a nonlinear equilibrium structure. By this microscopic nonlinear approach, its marginal stability against linear perturbations in both linear stability regimes, the sub- and super-critical one, is shown independent of the mobility of ions and in favor with recent observations. Responsible for vanishing damping (growth) is the microscopic distortion of the resonant distribution function. The macroscopic form of the trapping nonlinearity—the 3/2 power term of the electrostatic potential in the density—which disappears in the monochromatic harmonic wave limit is consequently necessary for the occurrence of a nonlinear plasma instability in the sub-critical regime.

Quantifier Comprehension in Corticobasal Degeneration

ERIC Educational Resources Information Center

McMillan, Corey T.; Clark, Robin; Moore, Peachie; Grossman, Murray

2006-01-01

In this study, we investigated patients with focal neurodegenerative diseases to examine a formal linguistic distinction between classes of generalized quantifiers, like "some X" and "less than half of X." Our model of quantifier comprehension proposes that number knowledge is required to understand both first-order and higher-order quantifiers.…

Who You Callin' White?! A Critical Counter-Story on Colouring White Identity

ERIC Educational Resources Information Center

Matias, Cheryl E.

2013-01-01

This action research, which utilizes critical race theory's counter-storytelling, analyses a process of debunking White students' epistemology of ignorance in a history course at an urban public high school. After piloting a raced curriculum that deliberately re-centers marginalized counter-stories of students of colour, I document its…

Molybdenum Cycling in Upwelling Sediments: An Example from Namibian Margin Sediments

NASA Astrophysics Data System (ADS)

Arnold, G. L.; Goldhammer, T.; Formolo, M.; Brunner, B.; Ferdelman, T.

2008-12-01

The paleo-redox application of molybdenum (Mo) isotopes is strongly tied to our knowledge of the modern marine Mo cycle. Elemental mass balance indicates that ~47% of the Mo supplied to the oceans is removed to deep sea sediments, leaving the remaining Mo to "near-shore" reducing sediments (1). The Black Sea is likely the best studied reducing environment with regards to Mo isotopes, yet accounts for only a small fraction of the Mo mass balance. The accumulation of Mo in continental margin sediments has been recently re-assessed and may account for a larger fraction of the marine Mo reservoir than previously thought (2). In the presence of sulfide, the molybdate anion is transformed, by the replacement of oxygen with sulfur, to particle reactive oxy-thiomolybdates (3). This is often cited as the mechanism by which Mo removal proceeds in the Black Sea where sulfide concentrations in the water are high. In contrast, in continental margin settings, the removal mechanism is poorly understood, and the extent to which sulfur cycling plays a role remains un-quantified. To better understand removal/cycling processes in a continental margin setting, where sulfide may only be present in the pore waters and not in the water column, Mo was studied in an array of marine settings off the Namibian coast. Surface sediments were collected across a transect from near-shore/high productivity to deep water/low productivity sediments. These sediments were incubated in bag experiments to study the relationship between sulfur and Mo cycling. Molybdenum concentrations in the Namibian sediments range from detrital values at the lowest productivity site to 25 ppm in surface sediments with high productivity. Preliminary results allude to a correlation between sulfate reduction rates and Mo accumulation in these sediments. Detailed studies of Mo, Mo isotopes, other trace metals, and sulfur investigations from both sediment cores and bag experiments will be presented. (1)Bertine and Turekian

Stroke: a Hidden Danger of Margin Trading in Stock Markets.

PubMed

Lin, Shu-Hui; Wang, Chien-Ho; Liu, Tsai-Ching; Chen, Chin-Shyan

2015-10-01

Using 10-year population data from 2000 through 2009 in Taiwan, this is the first paper to analyze the relationship between margin trading in stock markets and stroke hospitalizations. The results show that 3 and 6 days after an increase of margin trading in the Taiwan stock markets are associated with greater stoke hospitalizations. In general, a 1 % increase in total margin trading positions is associated with an increment of 2.5 in the total number of stroke hospitalizations, where the mean number of hospital admissions is 233 cases a day. We further examine the effects of margin trading by gender and age groups and find that the effects of margin trading are significant for males and those who are 45-74 years old only. In summary, buying stocks with money you do not have is quite risky, especially if the prices of those stocks fall past a certain level or if there is a sudden and severe drop in the stock market. There is also a hidden danger to one's health from margin trading. A person should be cautious before conducting margin trading, because while it can be quite profitable, danger always lurks just around the corner.

Improved Nazca slab structure from teleseismic P-wave tomography along the Andean margin

NASA Astrophysics Data System (ADS)

Portner, D. E.; Beck, S. L.; Scire, A. C.; Zandt, G.

2017-12-01

South America marks the longest continuous ocean-continent subduction zone. As such, there is significant along-strike variability in the subducting Nazca slab structure and the tectonics of the South American margin. Most notably two gaps in the otherwise continuous volcanic arc are correlated with regions of flat slab subduction, indicating that the structure of the Nazca slab plays a controlling role in South American tectonics. Traditionally in subduction zones, our knowledge of slab structure is defined by Wadati-Benioff zone earthquakes. While this method allows for the determination of large-scale variations in Nazca slab structure such as regions of flat slab subduction, a scarcity of intermediate-depth earthquakes hinders our ability to observe the smaller-scale structural variations in the slab that may be critical to our understanding of the geologic record. We use an updated, larger dataset for finite-frequency teleseismic P-wave tomography including relative arrival times from >700 seismic stations along the Andean margin to image the detailed Nazca slab structure throughout the upper mantle and uppermost lower mantle between latitudes 5°S and 45°S. Our results show prominent variations in slab character along the margin. Slab dip varies significantly, from sub-vertical inboard of the Peruvian flat slab segment to 30° dip south of the Pampean flat slab, while the slab's velocity anomaly amplitude changes dramatically near the Pampean flat slab region. High slab velocities north of the Pampean region relative to the south indicate variable slab thermal structures that correspond roughly with the locations of deep (>500 km depth) earthquakes that also occur exclusively north of the Pampean region. Additionally, a wider regional footprint increases our sampling of the upper-lower mantle boundary, improving constraints on the slab's interaction with the 660 km discontinuity along strike. We see that the Nazca slab appears to penetrate into the lower

Quantifying ocean and ice sheet contributions to nutrient fluxes in Sermilik Fjord, Southeast Greenland

NASA Astrophysics Data System (ADS)

Cape, M. R.; Straneo, F.; Beaird, N.; Bundy, R.; Charette, M. A.

2016-12-01

Meltwater discharged at the margins of the Greenland Ice Sheet (GrIS) represents a potential source of nutrients to biological communities downstream. In Greenland's glacial fjords, this discharge occurs at depth below and along the face of deeply grounded marine-terminating glaciers. This process drives vigorous circulation and mixing between melt and ambient waters at the ice-ocean margins, giving rise to a new glacially modified water mass (GMW) which constitutes the primary vehicle for transport of meltwater in the marine environment. While previous field studies have noted nutrient enrichment in GMW with respect to unmodified waters along the shelf, the source of this enrichment, whether due to entrainment of deep ambient waters or input by meltwater, remains poorly understood. This knowledge is however critical in order to evaluate the current and future contributions of the GrIS to marine biogeochemical cycling. Here we shed light on the distribution, composition, and properties of GMW along the GrIS margin by analyzing integrated physical and chemical measurements collected in August 2015 in Sermilik Fjord, a major glacial freshwater export pathway. Our results document up to a doubling of nutrient concentrations (nitrate, silicate, phosphate, and iron) in GMW, which is distributed in the top 300 m of the water column throughout the fjord. Partitioning of ocean and ice sheet contributions to GMW nutrient load demonstrates that upwelled waters are the primary source of macro-nutrients to GMW. We expand on these results to discuss the magnitude of fluxes in context of previous observations along the GrIS margins, export pathways of GMW to the shelf, and knowledge gaps needed to be addressed to better constrain ice sheet contributions to marine ecosystem processes.

Uplift history of a transform continental margin revealed by the stratigraphic record: The case of the Agulhas transform margin along the Southern African Plateau

NASA Astrophysics Data System (ADS)

Baby, Guillaume; Guillocheau, François; Boulogne, Carl; Robin, Cécile; Dall'Asta, Massimo

2018-04-01

The south and southeast coast of southern Africa (from 28°S to 33°S) forms a high-elevated transform passive margin bounded to the east by the Agulhas-Falkland Fracture Zone (AFFZ). We analysed the stratigraphic record of the Outeniqua and Durban (Thekwini) Basins, located on the African side of the AFFZ, to determine the evolution of these margins from the rifting stage to present-day. The goal was to reconstruct the strike-slip evolution of the Agulhas Margin and the uplift of the inland high-elevation South African Plateau. The Agulhas transform passive margin results from four successive stages: Rifting stage, from Late Triassic to Early Cretaceous ( 200?-134 Ma), punctuated by three successive rifting episodes related to the Gondwana breakup; Wrench stage (134-131 Ma), evidenced by strike- and dip-slip deformations increasing toward the AFFZ; Active transform margin stage (131-92 Ma), during which the Falkland/Malvinas Plateau drifts away along the AFFZ, with an uplift of the northeastern part of the Outeniqua Basin progressively migrating toward the west; Thermal subsidence stage (92-0 Ma), marked by a major change in the configuration of the margin (onset of the shelf-break passive margin morphology). Two main periods of uplift were documented during the thermal subsidence stage of the Agulhas Margin: (1) a 92 Ma short-lived margin-scale uplift, followed by a second one at 76 Ma located along the Outeniqua Basin and; (2) a long-lasting uplift from 40 to 15 Ma limited to the Durban (Thekwini) Basin. This suggests that the South African Plateau is an old Upper Cretaceous relief (90-70 Ma) reactivated during Late Eocene to Early Miocene times (40-15 Ma).

Critical Values for Lawshe's Content Validity Ratio: Revisiting the Original Methods of Calculation

ERIC Educational Resources Information Center

Ayre, Colin; Scally, Andrew John

2014-01-01

The content validity ratio originally proposed by Lawshe is widely used to quantify content validity and yet methods used to calculate the original critical values were never reported. Methods for original calculation of critical values are suggested along with tables of exact binomial probabilities.

The Ebro margin study, northwestern Mediterranean Sea - an introduction

USGS Publications Warehouse

Maldonado, A.; Hans, Nelson C.

1990-01-01

The Ebro continental margin from the coast to the deep sea off northeastern Spain was selected for a multidisciplinary project because of the abundant Ebro River sediment supply, Pliocene and Quaternary progradation, and margin development in a restricted basin where a variety of controlling factors could be evaluated. The nature of this young passive margin for the last 5 m.y. was investigated with particular emphasis on marine circulation, sediment dynamics, sediment geochemistry, depositional facies, seismic stratigraphy, geotechnical properties, geological hazards and human influences. These studies show the importance of marine circulation, variation in sediment supply, sea-level oscillation and tectonic setting for the understanding of modern and ancient margin depositional processes and growth patterns. ?? 1990.

Marginal oil fields, profitable oil at low reserves: How?

DOE Office of Scientific and Technical Information (OSTI.GOV)

Agiza, M.N.; Shaheen, S.E.; Barawi, S.A.

1995-12-31

Fields with recoverable reserves of about five million barrels of oil are considered in Egypt as marginal fields. Economics of Egyptian marginal oil fields depend on non-traditional approaches followed in developing and operating such fields. The actual exploration, development and operating expenses and state fiscal terms were used to evaluate the sensitivity of the economic parameters of such marginal fields. The operator net present value (NPV) and internal rate of return (IRR) beside the government take are presented for different parameters used. The purpose is to make acceptable profits out of the marginal oil fields, for the mutual benefits ofmore » both the country and the investors.« less

Diesel Emissions Quantifier (DEQ)

EPA Pesticide Factsheets

.The Diesel Emissions Quantifier (Quantifier) is an interactive tool to estimate emission reductions and cost effectiveness. Publications EPA-420-F-13-008a (420f13008a), EPA-420-B-10-035 (420b10023), EPA-420-B-10-034 (420b10034)

Margins in extra-abdominal desmoid tumors: a comparative analysis.

PubMed

Leithner, Andreas; Gapp, Markus; Leithner, Katharina; Radl, Roman; Krippl, Peter; Beham, Alfred; Windhager, Reinhard

2004-06-01

The main treatment of extra-abdominal desmoid tumors remains surgery, but recurrence rates up to 80% are reported. The impact of microscopic surgical margin status according to the Enneking classification system is discussed controversially. Therefore, the authors screened the published literature for reliable data on the importance of a wide or radical excision of extra-abdominal desmoid tumors. All studies with more than ten patients, a surgical treatment only, and margin status stated were included. Only 12 out of 49 identified studies fulfilled the inclusion criteria. One hundred fifty-two primary tumors were excised with wide or radical microscopic surgical margins, while in 260 cases a marginal or intralesional excision was performed. In the first group 41 patients (27%) and in the second one 187 patients (72%) developed a recurrence. Therefore, microscopic surgical margin status according to the Enneking classification system is a significant prognostic factor (P < 0.001). The data of this review underline the strategy of a wide or radical local excision as the treatment of choice. Furthermore, as a large number of studies had to be excluded from this analysis, exact microscopic surgical margin status should be provided in future studies in order to allow comparability. . Copyright 2004 Wiley-Liss, Inc.

Volcanic passive margins: another way to break up continents

PubMed Central

Geoffroy, L.; Burov, E. B.; Werner, P.

2015-01-01

Two major types of passive margins are recognized, i.e. volcanic and non-volcanic, without proposing distinctive mechanisms for their formation. Volcanic passive margins are associated with the extrusion and intrusion of large volumes of magma, predominantly mafic, and represent distinctive features of Larges Igneous Provinces, in which regional fissural volcanism predates localized syn-magmatic break-up of the lithosphere. In contrast with non-volcanic margins, continentward-dipping detachment faults accommodate crustal necking at both conjugate volcanic margins. These faults root on a two-layer deformed ductile crust that appears to be partly of igneous nature. This lower crust is exhumed up to the bottom of the syn-extension extrusives at the outer parts of the margin. Our numerical modelling suggests that strengthening of deep continental crust during early magmatic stages provokes a divergent flow of the ductile lithosphere away from a central continental block, which becomes thinner with time due to the flow-induced mechanical erosion acting at its base. Crustal-scale faults dipping continentward are rooted over this flowing material, thus isolating micro-continents within the future oceanic domain. Pure-shear type deformation affects the bulk lithosphere at VPMs until continental breakup, and the geometry of the margin is closely related to the dynamics of an active and melting mantle. PMID:26442807

Volcanic passive margins: another way to break up continents.

PubMed

Geoffroy, L; Burov, E B; Werner, P

2015-10-07

Two major types of passive margins are recognized, i.e. volcanic and non-volcanic, without proposing distinctive mechanisms for their formation. Volcanic passive margins are associated with the extrusion and intrusion of large volumes of magma, predominantly mafic, and represent distinctive features of Larges Igneous Provinces, in which regional fissural volcanism predates localized syn-magmatic break-up of the lithosphere. In contrast with non-volcanic margins, continentward-dipping detachment faults accommodate crustal necking at both conjugate volcanic margins. These faults root on a two-layer deformed ductile crust that appears to be partly of igneous nature. This lower crust is exhumed up to the bottom of the syn-extension extrusives at the outer parts of the margin. Our numerical modelling suggests that strengthening of deep continental crust during early magmatic stages provokes a divergent flow of the ductile lithosphere away from a central continental block, which becomes thinner with time due to the flow-induced mechanical erosion acting at its base. Crustal-scale faults dipping continentward are rooted over this flowing material, thus isolating micro-continents within the future oceanic domain. Pure-shear type deformation affects the bulk lithosphere at VPMs until continental breakup, and the geometry of the margin is closely related to the dynamics of an active and melting mantle.

Structure of the North American Atlantic Continental Margin.

ERIC Educational Resources Information Center

Klitgord, K. K.; Schlee, J. S.

1986-01-01

Offers explanations on the origin of the North American Atlantic continental margin. Provides an analysis and illustrations of structural and strategraphic elements of cross sections of the Atlantic continental margin. Also explains the operations and applications of seismic-relection profiles in studying ocean areas. (ML)

Quantifying structural states of soft mudrocks

NASA Astrophysics Data System (ADS)

Li, B.; Wong, R. C. K.

2016-05-01

In this paper, a cm model is proposed to quantify structural states of soft mudrocks, which are dependent on clay fractions and porosities. Physical properties of natural and reconstituted soft mudrock samples are used to derive two parameters in the cm model. With the cm model, a simplified homogenization approach is proposed to estimate geomechanical properties and fabric orientation distributions of soft mudrocks based on the mixture theory. Soft mudrocks are treated as a mixture of nonclay minerals and clay-water composites. Nonclay minerals have a high stiffness and serve as a structural framework of mudrocks when they have a high volume fraction. Clay-water composites occupy the void space among nonclay minerals and serve as an in-fill matrix. With the increase of volume fraction of clay-water composites, there is a transition in the structural state from the state of framework supported to the state of matrix supported. The decreases in shear strength and pore size as well as increases in compressibility and anisotropy in fabric are quantitatively related to such transition. The new homogenization approach based on the proposed cm model yields better performance evaluation than common effective medium modeling approaches because the interactions among nonclay minerals and clay-water composites are considered. With wireline logging data, the cm model is applied to quantify the structural states of Colorado shale formations at different depths in the Cold Lake area, Alberta, Canada. Key geomechancial parameters are estimated based on the proposed homogenization approach and the critical intervals with low strength shale formations are identified.

Effect of CNC-milling on the marginal and internal fit of dental ceramics: a pilot study.

PubMed

Schaefer, Oliver; Kuepper, Harald; Thompson, Geoffrey A; Cachovan, Georg; Hefti, Arthur F; Guentsch, Arndt

2013-08-01

Machined restorations have been investigated for their preciseness before, while detailed information on the milling-step itself are lacking. Therefore, the aim of this laboratory study was to quantify the effect of a novel milling-procedure on the marginal and internal fit of ceramic restorations. An acrylic model of a lower left first molar was prepared to receive a ceramic partial crown and was duplicated by one step dual viscosity impressions. Gypsum casts were formed and laser-scanned to realize virtual datasets, before restorations were designed, exported (PRE) and machined from lithium disilicate blanks. Crowns were digitized by a structure-light-scanner to obtain post-milling-data (POST). PRE and POST were virtually superimposed on the reference tooth and subjected to computer-aided-inspection. Visual fit-discrepancies were displayed with colors, while root mean square deviations (RMSD) and degrees of similarity (DS) were computed and analysed by t-tests for paired samples (n=5, α=0.05). The milling procedure resulted in a small increase of the marginal and internal fit discrepancies (RMSD mean: 3μm and 6μm, respectively). RMSD differences were not statistically significant (p=0.495 and p=0.160 for marginal and internal fit, respectively). These results were supported by the DS data. The products of digital dental workflows are prone to imprecisions. However, the present findings suggest that differences between computer-aided designed and actually milled restorations are small, especially when compared to typical fit discrepancies observed clinically. Imprecisions introduced by digital design or production processes are small. Copyright © 2013 Academy of Dental Materials. Published by Elsevier Ltd. All rights reserved.

[Banff score changes in kidneys from marginal donors].

PubMed

Borda, Bernadett; Szederkényi, Edit; Ottlakán, Aurél; Kemény, Éva; Szabó, Viktor; Hódi, Zoltán; Lázár, György

2016-02-21

Despite an increase in the number of cadaver donors and the number of overall organ transplantations, the dramatic increase in the waiting list makes it necessary to reconsider donor criteria. The authors examined whether differences could exist in the function and/or morphology of transplanted kidneys originated from marginal and ideal donors one and five years after transplantation. Kidney function and histopathologic findings were analysed and compared one and 5 years after transplantation in 97 patients having marginal donor kidneys and 178 patients who received ideal donor kidneys. Serum creatinine level was significantly higher (p = 0.0001) and estimated glomerular filtration rate was significantly lower (p = 0.003) in patients having marginal donor kidneys as compared to those with ideal donor kidneys 5 years after transplantation. Morphological changes in the transplanted kidneys such as tubulitis (p = 0.014) and interstitial inflammation (p = 0.025) were significantly more frequently present in patients with marginal donor kidneys than in those with ideal donor kidneys one year after transplantation. Despite an absence of differences in kidney function one year after kidney transplantation between patients having marginal and ideal donor kidneys, morphologic differences in the transplanted kidneys can be detected between the two groups of patients.

Influence of Different Ceramic Systems on Marginal Misfit.

PubMed

Vargas, S P; Neves, A C C; Vitti, R; Amaral, M; Henrique, M N; Silva-Concílio, L R

2017-09-01

the aim of this study was to evaluate the marginal misfit at the interface between a ceramic coping and its abutment. Twenty-four specimens were made with solid abutments. The specimens were divided into 3 groups according to the ceramic system (n = 8): Lava (zirconia), IPS e.max Press (lithium disilicate), and IPS Empress Esthetic (leucite). All copings were cemented with resin luting agent (RelyX U200) and the marginal misfit were evaluated at 3 different times: initial, after cementation, and after mechanical cycling using a linear measuring microscope (Measuring Microscope STM-Olympus) at a magnification of 40x. All specimens were subjected to mechanical cycling (1 million cycles) by an universal testing machine (Instron 8800). The results were statistically analyzed using Analysis of Variance and Student's t-test (α = 0.05). all groups showed an increase in the marginal misfit after cementation. The lithium disilicate group demonstrated the lowest interacial gap values at each evaluation (p = 0.001). The zirconia and leucite groups showed similar interfacial gap values (initial, p = 0.244; and post cementation, p = 0.751). the cementation increase the marginal misfit, but the mechanical cycling did not influence the marginal misfit of the ceramics systems evaluated. Copyright© 2017 Dennis Barber Ltd.

37 CFR 1.52 - Language, paper, writing, margins, compact disc specifications.

Code of Federal Regulations, 2010 CFR

2010-07-01

... cm (3/4 inch), a left side margin of at least 2.5 cm (1 inch), a right side margin of at least 2.0 cm... brackets should appear to the right of the left margin as the first item in each paragraph, before the... elements, and should not be independently numbered. If a nontext element extends to the left margin, it...

Study of a safety margin system for powered-lift STOL aircraft

NASA Technical Reports Server (NTRS)

Heffley, R. K.; Jewell, W. F.

1978-01-01

A study was conducted to explore the feasibility of a safety margin system for powered-lift aircraft which require a backside piloting technique. The objective of the safety margin system was to present multiple safety margin criteria as a single variable which could be tracked manually or automatically and which could be monitored for the purpose of deriving safety margin status. The study involved a pilot-in-the-loop analysis of several safety margin system concepts and a simulation experiment to evaluate those concepts which showed promise of providing a good solution. A system was ultimately configured which offered reasonable compromises in controllability, status information content, and the ability to regulate the safety margin at some expense of the allowable low speed flight path envelope.

Supervised linear dimensionality reduction with robust margins for object recognition

NASA Astrophysics Data System (ADS)

Dornaika, F.; Assoum, A.

2013-01-01

Linear Dimensionality Reduction (LDR) techniques have been increasingly important in computer vision and pattern recognition since they permit a relatively simple mapping of data onto a lower dimensional subspace, leading to simple and computationally efficient classification strategies. Recently, many linear discriminant methods have been developed in order to reduce the dimensionality of visual data and to enhance the discrimination between different groups or classes. Many existing linear embedding techniques relied on the use of local margins in order to get a good discrimination performance. However, dealing with outliers and within-class diversity has not been addressed by margin-based embedding method. In this paper, we explored the use of different margin-based linear embedding methods. More precisely, we propose to use the concepts of Median miss and Median hit for building robust margin-based criteria. Based on such margins, we seek the projection directions (linear embedding) such that the sum of local margins is maximized. Our proposed approach has been applied to the problem of appearance-based face recognition. Experiments performed on four public face databases show that the proposed approach can give better generalization performance than the classic Average Neighborhood Margin Maximization (ANMM). Moreover, thanks to the use of robust margins, the proposed method down-grades gracefully when label outliers contaminate the training data set. In particular, we show that the concept of Median hit was crucial in order to get robust performance in the presence of outliers.

Quantifying Transmission.

PubMed

Woolhouse, Mark

2017-07-01

Transmissibility is the defining characteristic of infectious diseases. Quantifying transmission matters for understanding infectious disease epidemiology and designing evidence-based disease control programs. Tracing individual transmission events can be achieved by epidemiological investigation coupled with pathogen typing or genome sequencing. Individual infectiousness can be estimated by measuring pathogen loads, but few studies have directly estimated the ability of infected hosts to transmit to uninfected hosts. Individuals' opportunities to transmit infection are dependent on behavioral and other risk factors relevant given the transmission route of the pathogen concerned. Transmission at the population level can be quantified through knowledge of risk factors in the population or phylogeographic analysis of pathogen sequence data. Mathematical model-based approaches require estimation of the per capita transmission rate and basic reproduction number, obtained by fitting models to case data and/or analysis of pathogen sequence data. Heterogeneities in infectiousness, contact behavior, and susceptibility can have substantial effects on the epidemiology of an infectious disease, so estimates of only mean values may be insufficient. For some pathogens, super-shedders (infected individuals who are highly infectious) and super-spreaders (individuals with more opportunities to transmit infection) may be important. Future work on quantifying transmission should involve integrated analyses of multiple data sources.

Marginal adaptation of composite resins under two adhesive techniques.

PubMed

Dačić, Stefan; Veselinović, Aleksandar M; Mitić, Aleksandar; Nikolić, Marija; Cenić, Milica; Dačić-Simonović, Dragica

2016-11-01

In the present research, different adhesive techniques were used to set up fillings with composite resins. After the application of etch and rinse or self etch adhesive technique, marginal adaptation of composite fillings was estimated by the length of margins without gaps, and by the microretention of resin in enamel and dentin. The study material consisted of 40 extracted teeth. Twenty Class V cavities were treated with 35% phosphorous acid and restored after rinsing by Adper Single Bond 2 and Filtek Ultimate-ASB/FU 3M ESPE composite system. The remaining 20 cavities were restored by Adper Easy One-AEO/FU 3M ESPE composite system. Marginal adaptation of composite fillings was examined using a scanning electron microscope (SEM). The etch and rinse adhesive technique showed a significantly higher percentage of margin length without gaps (in enamel: 92.5%, in dentin: 57.3%), compared with the self-etch technique with lower percentage of margin length without gaps, in enamel 70.4% (p < .001), and in dentin-22.6% (p < .05). In the first technique, microretention was composed of adhesive and hybrid layers as well as resin tugs in interprismatic spaces of enamel, while the dentin microretention was composed of adhesive and hybrid layers with resin tugs in dentin canals. In the second technique, resin tugs were rarely seen and a microgap was dominant along the border of restoration margins. The SEM analysis showed a better marginal adaptation of composite resin to enamel and dentin with better microretention when the etch and rinse adhesive procedure was applied. © 2016 Wiley Periodicals, Inc.

Influence of margin segmentation and anomalous volcanism upon the break-up of the Hatton Bank rifted margin, west of the UK

NASA Astrophysics Data System (ADS)

Elliott, G. M.; Parson, L. M.

2007-12-01

The Hatton Bank margin, flanking the Iceland Basin is a widely cited example of a volcanic rifted margin. Prior to this study insights into the break-up history of the margin have been limited to profiles in the north and south, yet whilst valuable, the along margin tectono-magmatic variability has not been revealed. Over 5660 line km of high quality reflection seismic profiles with supplementary multibeam bathymetry were collected to support the UK's claim to Hatton region under the United Nations Convention on Law of the Sea (UNCLOS). Integration of this new data with existing profiles, allowed the margin to be divided into three segments, each of which are flanked by oceanic crust with a smooth upper surface and internal dipping reflectors. The southernmost segment is characterised by a series of inner and outer seaward dipping reflector (SDR) packages, which are separated by an outer high feature. The outer SDR are truncated by Endymion Spur, a chain of steep sided, late stage volcanic cones linked with necks. The central sector has no inner SDR package and is characterised by the presence of a highly intruded continental block, the Hatton Bank Block (HBB). The northern sector is adjacent to Lousy Bank, with a wider region of SDR recognised than to the south and a high amount of volcanic cones imaged. The variations in the distribution of the SDR's along the margin, the presence of the HBB and Endymion Spur all suggest that the break-up process was not uniform alongstrike. The division of the margin into three sectors reveals that structural segmentation played an important role in producing the variations along the margin. Break- up initiated in the south and progressed north producing the SDR packages witnessed, when the HBB was encountered the focus of break-up moved seaward of the block. The northern sector was closer to the Iceland Hotspot and hence a greater amount of volcanism is encountered. The smooth oceanic basement also indicates a high thermal flux

[The economic margins of activities of a bovine practitioner on dairy farms].

PubMed

van Genugten, A J M; van Haaften, J A; Hogeveen, H

2011-11-01

Because of lower margins and market liberalisation veterinarians and farmers are increasingly negotiating rates. Therefore, the margins of veterinarians are under pressure. In addition, the sales if drugs, performance of operations or giving of advice are more and more separated. These developments give veterinarians uncertainty about the profitability of their activities for dairy farmers. Not much is known about margins on veterinary activities on dairy farms. Moreover, it is interesting to see how much margins of the bovine practitioner differ between veterinary practises and dairy farms. In this study, invoices for bovine activities of 14 veterinary practises were combined with milk production registration data of the dairy farms of these practices. This way, the gross margin per bovine practitioner could be studied for the different veterinary practise. Moreover the relation between gross margin and specification of the veterinary practise could be studied. Finally, the gross margin per dairy farm and the factors that influenced this gross margin were studied. The most important result was the observation that the gross margin per bovine practitioner was dependent on the number of dairy farms per practitioner, the margin on drugs and the region of the veterinary practise. The size of the veterinary practise, the share of the dairy farming within the practise and the source of the gross margin (drugs, time or operations) did not influence the gross margin. Variables that explained the gross margin per dairy farm were, amongst others, the number of dairy cows, the milk production level of the farms and participation in PIR-DAP (a system to support the veterinarians herd health and management program). There is no relation of gross margin per dairy farm and the veterinary practise or region.

Helping Students on the Margin Succeed in Schools.

ERIC Educational Resources Information Center

Langenfeld, Michelle Schoen; Cumming, Brenda

1996-01-01

Addresses how Apple Valley High School (Minnesota) has been able to help marginal students succeed in school. The fundamental actions that contributed to the effectiveness of study-team efforts to help marginal students are discussed, and what has been learned through these efforts is considered. (GR)

Principals' Perceived Supervisory Behaviors Regarding Marginal Teachers in Two States

ERIC Educational Resources Information Center

Range, Bret; Hewitt, Paul; Young, Suzie

2014-01-01

This descriptive study used an online survey to determine how principals in two states viewed the supervision of marginal teachers. Principals ranked their own evaluation of the teacher as the most important factor when identifying marginal teachers and relied on informal methods to diagnose marginal teaching. Female principals rated a majority of…

Quantifying Access Disparities in Response Plans

PubMed Central

Indrakanti, Saratchandra; Mikler, Armin R.; O’Neill, Martin; Tiwari, Chetan

2016-01-01

Effective response planning and preparedness are critical to the health and well-being of communities in the face of biological emergencies. Response plans involving mass prophylaxis may seem feasible when considering the choice of dispensing points within a region, overall population density, and estimated traffic demands. However, the plan may fail to serve particular vulnerable subpopulations, resulting in access disparities during emergency response. For a response plan to be effective, sufficient mitigation resources must be made accessible to target populations within short, federally-mandated time frames. A major challenge in response plan design is to establish a balance between the allocation of available resources and the provision of equal access to PODs for all individuals in a given geographic region. Limitations on the availability, granularity, and currency of data to identify vulnerable populations further complicate the planning process. To address these challenges and limitations, data driven methods to quantify vulnerabilities in the context of response plans have been developed and are explored in this article. PMID:26771551

Critical Work Education and Social Exclusion: Unemployed Youths at the Margins in the New Economy

ERIC Educational Resources Information Center

Lakes, Richard D.

2005-01-01

This article discusses the impact of critical work education and social exclusion in aiding and assisting school-aged children and young adults through projects that help reshape their connections to self and society. The visual and performing arts gave at-risk young people opportunities to explore their biographical histories and personal…

Radiobiological Impact of Reduced Margins and Treatment Technique for Prostate Cancer in Terms of Tumor Control Probability (TCP) and Normal Tissue Complication Probability (NTCP)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jensen, Ingelise, E-mail: inje@rn.d; Carl, Jesper; Lund, Bente

2011-07-01

Dose escalation in prostate radiotherapy is limited by normal tissue toxicities. The aim of this study was to assess the impact of margin size on tumor control and side effects for intensity-modulated radiation therapy (IMRT) and 3D conformal radiotherapy (3DCRT) treatment plans with increased dose. Eighteen patients with localized prostate cancer were enrolled. 3DCRT and IMRT plans were compared for a variety of margin sizes. A marker detectable on daily portal images was presupposed for narrow margins. Prescribed dose was 82 Gy within 41 fractions to the prostate clinical target volume (CTV). Tumor control probability (TCP) calculations based on themore » Poisson model including the linear quadratic approach were performed. Normal tissue complication probability (NTCP) was calculated for bladder, rectum and femoral heads according to the Lyman-Kutcher-Burman method. All plan types presented essentially identical TCP values and very low NTCP for bladder and femoral heads. Mean doses for these critical structures reached a minimum for IMRT with reduced margins. Two endpoints for rectal complications were analyzed. A marked decrease in NTCP for IMRT plans with narrow margins was seen for mild RTOG grade 2/3 as well as for proctitis/necrosis/stenosis/fistula, for which NTCP <7% was obtained. For equivalent TCP values, sparing of normal tissue was demonstrated with the narrow margin approach. The effect was more pronounced for IMRT than 3DCRT, with respect to NTCP for mild, as well as severe, rectal complications.« less

Importance of flexure in response to sedimentation and erosion along the US Atlantic passive margin in reconciling sea level change and paleoshorelines

NASA Astrophysics Data System (ADS)

Moucha, R.; Ruetenik, G.; de Boer, B.

2017-12-01

Reconciling elevations of paleoshorelines along the US Atlantic passive margin with estimates of eustatic sea level have long posed to be a challenge. Discrepancies between shoreline elevation and sea level have been attributed to combinations of tectonics, glacial isostatic adjustment, mantle convection, gravitation and/or errors, for example, in the inference of eustatic sea level from the marine 18O record. Herein we present a numerical model of landscape evolution combined with sea level change and solid Earth deformations to demonstrate the importance of flexural effects in response to erosion and sedimentation along the US Atlantic passive margin. We quantify these effects using two different temporal models. One reconciles the Orangeburg scarp, a well-documented 3.5 million-year-old mid-Pliocene shoreline, with a 15 m mid-Pliocene sea level above present-day (Moucha and Ruetenik, 2017). The other model focuses on the evolution of the South Carolina and northern Georgia margin since MIS 11 ( 400 Ka) using a fully coupled ice sheet, sea level and solid Earth model (de Boer et al, 2014) while relating our results to a series of enigmatic sea level high stand markers. de Boer, B., Stocci, P., and van de Wal, R. (2014). A fully coupled 3-d ice-sheet-sea-level model: algorithm and applications. Geoscientific Model Development, 7:2141-2156. Moucha, R. and Ruetenik, G. A. (2017). Interplay between dynamic topography and flexure along the US Atlantic passive margin: Insights from landscape evolution modeling. Global and Planetary Change, 149: 72-78

Intraoperative monitoring of marginal mandibular nerve during neck dissection.

PubMed

Tirelli, Giancarlo; Bergamini, Pier Riccardo; Scardoni, Alessandro; Gatto, Annalisa; Boscolo Nata, Francesca; Marcuzzo, Alberto Vito

2018-05-01

The purpose of this study was to assess the efficacy of intraoperative nerve integrity monitoring (NIM) to prevent marginal mandibular nerve injuries during neck dissection. This prospective study compared 36 patients undergoing NIM-assisted neck dissection from July 2014 to March 2015 to a cohort of 35 patients subjected to neck dissection over an identical period of time before the technique was introduced. We also assessed possible correlations between marginal mandibular nerve injuries and other factors, such as anthropometric measurements, presence of clinical neck metastases, type of neck dissection, and site of primary tumor. The incidence of marginal mandibular nerve paralyses was significantly lower among the group of patients undergoing NIM-assisted neck dissection (P = .021). There was no significant difference in the duration of the procedure, and the technique resulted in a limited increase of cost. No other factor seemed to influence the onset of marginal mandibular nerve palsy. In our opinion, NIM is a valuable aid for preventing marginal mandibular nerve injuries during neck dissection. © 2018 Wiley Periodicals, Inc.

Patents and profits: A disparity of manufacturing margins in the tenofovir value chain.

PubMed

Walwyn, David

2013-03-01

Registered in 2001, tenofovir disoproxil fumarate (TDF) has quickly become a mainstay of first line regimens for the treatment of HIV. Initially only available in developed countries at a cost of US$5 000 per person per year (ppy), Gilead's Access Programme (GAP) has extended the use of the product to 2.4 million patients in low and middle income countries. The programme has two components: distribution of the branded product at reduced prices and licensing partnerships with generic manufacturers. The licensing partnerships now supply 75% of the market by volume, at a treatment cost of US$57 ppy (1% of the branded cost). From Gilead's perspective, GAP must be considered a huge success. It has enabled the company to maintain high prices in developed countries whilst reducing its input costs and deflecting criticism of its failure to provide essential medicines for the poor, hence risking the possibility of compulsory licensing. Over the period 2001 to 2011, TDF in its various forms has generated for Gilead more than US$31 billion revenue at a gross margin of 80%, equivalent to a gross profit of US$25 billion. Analysis of the TDF value chain, from preparation of the active pharmaceutical ingredient (API) to sale of the formulated product, shows that manufacturing margins are highly skewed in favour of the originator, with the latter's profit being US$3.2 billion vs. US$4 million for API manufacturers and US$39 million for formulators (2011). The data argues for a more rational approach to drug pricing including possible regulation in developed countries and more sustainable margins for the generic producers.

Control of finite critical behaviour in a small-scale social system

NASA Astrophysics Data System (ADS)

Daniels, Bryan C.; Krakauer, David C.; Flack, Jessica C.

2017-02-01

Many adaptive systems sit near a tipping or critical point. For systems near a critical point small changes to component behaviour can induce large-scale changes in aggregate structure and function. Criticality can be adaptive when the environment is changing, but entails reduced robustness through sensitivity. This tradeoff can be resolved when criticality can be tuned. We address the control of finite measures of criticality using data on fight sizes from an animal society model system (Macaca nemestrina, n=48). We find that a heterogeneous, socially organized system, like homogeneous, spatial systems (flocks and schools), sits near a critical point; the contributions individuals make to collective phenomena can be quantified; there is heterogeneity in these contributions; and distance from the critical point (DFC) can be controlled through biologically plausible mechanisms exploiting heterogeneity. We propose two alternative hypotheses for why a system decreases the distance from the critical point.

46 CFR 171.015 - Location of margin line.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 7 2010-10-01 2010-10-01 false Location of margin line. 171.015 Section 171.015 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) SUBDIVISION AND STABILITY SPECIAL RULES PERTAINING TO VESSELS CARRYING PASSENGERS General § 171.015 Location of margin line. (a) A vessel with a...

Shyok Suture Zone, N Pakistan: late Mesozoic Tertiary evolution of a critical suture separating the oceanic Ladakh Arc from the Asian continental margin

NASA Astrophysics Data System (ADS)

Robertson, Alastair H. F.; Collins, Alan S.

2002-02-01

The Shyok Suture Zone (Northern Suture) of North Pakistan is an important Cretaceous-Tertiary suture separating the Asian continent (Karakoram) from the Cretaceous Kohistan-Ladakh oceanic arc to the south. In previously published interpretations, the Shyok Suture Zone marks either the site of subduction of a wide Tethyan ocean, or represents an Early Cretaceous intra-continental marginal basin along the southern margin of Asia. To shed light on alternative hypotheses, a sedimentological, structural and igneous geochemical study was made of a well-exposed traverse in North Pakistan, in the Skardu area (Baltistan). To the south of the Shyok Suture Zone in this area is the Ladakh Arc and its Late Cretaceous, mainly volcanogenic, sedimentary cover (Burje-La Formation). The Shyok Suture Zone extends northwards (ca. 30 km) to the late Tertiary Main Karakoram Thrust that transported Asian, mainly high-grade metamorphic rocks southwards over the suture zone. The Shyok Suture Zone is dominated by four contrasting units separated by thrusts, as follows: (1). The lowermost, Askore amphibolite, is mainly amphibolite facies meta-basites and turbiditic meta-sediments interpreted as early marginal basin rift products, or trapped Tethyan oceanic crust, metamorphosed during later arc rifting. (2). The overlying Pakora Formation is a very thick (ca. 7 km in outcrop) succession of greenschist facies volcaniclastic sandstones, redeposited limestones and subordinate basaltic-andesitic extrusives and flow breccias of at least partly Early Cretaceous age. The Pakora Formation lacks terrigenous continental detritus and is interpreted as a proximal base-of-slope apron related to rifting of the oceanic Ladakh Arc; (3). The Tectonic Melange (<300 m thick) includes serpentinised ultramafic rocks, near mid-ocean ridge-type volcanics and recrystallised radiolarian cherts, interpreted as accreted oceanic crust. (4). The Bauma-Harel Group (structurally highest) is a thick succession (several km

Polar continental margins: Studies off East Greenland

NASA Astrophysics Data System (ADS)

Mienert, J.; Thiede, J.; Kenyon, N. H.; Hollender, F.-J.

The passive continental margin off east Greenland has been shaped by tectonic and sedimentary processes, and typical physiographic patterns have evolved over the past few million years under the influence of the late Cenozoic Northern Hemisphere glaciations. The Greenland ice shield has been particularly affected.GLORIA (Geological Long Range Inclined Asdic), the Institute of Oceanographic Sciences' (IOS) long-range, side-scan sonar, was used on a 1992 RV Livonia cruise to map large-scale changes in sedimentary patterns along the east Greenland continental margin. The overall objective of this research program was to determine the variety of large-scale seafloor processes to improve our understanding of the interaction between ice sheets, current regimes, and sedimentary processes. In cooperation with IOS and the RV Livonia, a high-quality set of seafloor data has been produced. GLORIA'S first survey of east Greenland's continental margin covered several 1000- × 50-km-wide swaths (Figure 1) and yielded an impressive sidescan sonar image of the complete Greenland Basin and margin (about 250,000 km2). A mosaic of the data was made at a scale of 1:375,000. The base map was prepared with a polar stereographic projection having a standard parallel of 71°.

Sustainable biomass production on Marginal Lands (SEEMLA)

NASA Astrophysics Data System (ADS)

Barbera, Federica; Baumgarten, Wibke; Pelikan, Vincent

2017-04-01

Sustainable biomass production on Marginal Lands (SEEMLA) The main objective of the H2020 funded EU project SEEMLA (acronym for Sustainable Exploitation of Biomass for Bioenergy from Marginal Lands in Europe) is the establishment of suitable innovative land-use strategies for a sustainable production of plant-based energy on marginal lands while improving general ecosystem services. The use of marginal lands (MagL) could contribute to the mitigation of the fast growing competition between traditional food production and production of renewable bio-resources on arable lands. SEEMLA focuses on the promotion of re-conversion of MagLs for the production of bioenergy through the direct involvement of farmers and forester, the strengthening of local small-scale supply chains, and the promotion of plantations of bioenergy plants on MagLs. Life cycle assessment is performed in order to analyse possible impacts on the environment. A soil quality rating tool is applied to define and classify MagL. Suitable perennial and woody bioenergy crops are selected to be grown in pilot areas in the partner countries Ukraine, Greece and Germany. SEEMLA is expected to contribute to an increasing demand of biomass for bioenergy production in order to meet the 2020 targets and beyond.

Evaluation of the marginal fit of metal copings fabricated on three different marginal designs using conventional and accelerated casting techniques: an in vitro study.

PubMed

Vaidya, Sharad; Parkash, Hari; Bhargava, Akshay; Gupta, Sharad

2014-01-01

Abundant resources and techniques have been used for complete coverage crown fabrication. Conventional investing and casting procedures for phosphate-bonded investments require a 2- to 4-h procedure before completion. Accelerated casting techniques have been used, but may not result in castings with matching marginal accuracy. The study measured the marginal gap and determined the clinical acceptability of single cast copings invested in a phosphate-bonded investment with the use of conventional and accelerated methods. One hundred and twenty cast coping samples were fabricated using conventional and accelerated methods, with three finish lines: Chamfer, shoulder and shoulder with bevel. Sixty copings were prepared with each technique. Each coping was examined with a stereomicroscope at four predetermined sites and measurements of marginal gaps were documented for each. A master chart was prepared for all the data and was analyzed using Statistical Package for the Social Sciences version. Evidence of marginal gap was then evaluated by t-test. Analysis of variance and Post-hoc analysis were used to compare two groups as well as to make comparisons between three subgroups . Measurements recorded showed no statistically significant difference between conventional and accelerated groups. Among the three marginal designs studied, shoulder with bevel showed the best marginal fit with conventional as well as accelerated casting techniques. Accelerated casting technique could be a vital alternative to the time-consuming conventional casting technique. The marginal fit between the two casting techniques showed no statistical difference.

The Variability in Surgical Margin Reporting in Limb Salvage Surgery for Sarcoma

PubMed Central

Hoang, Kevin; Gao, Yubo; Miller, Benjamin J.

2015-01-01

Background Surgical margins are a standard reported measurement in tumor surgery that has implications for functional outcome, local control, and overall survival. There is no single accepted classification, and it is unclear what form or margin reporting predominates in the sarcoma literature. Methods We performed a PubMed literature search to identify articles that reported surgical margins and oncologic outcomes in limb salvage surgery for sarcoma from 1980 to 2013. We recorded the margin classification, specialty of the journal, specialty of the author, and location of the authors' institution. Results We found that 159/448 (35%) of articles included in the study did not report surgical margins. Of the 289 papers that did include data on margins, 160 (55%) of articles used Enneking's classification. There has been an increase over time in the proportion of articles reporting surgical margins by the residual tumor (R) classification and the proportion of articles reporting margins dichotomously as “positive” or “negative.” Conclusions We did not find a common method for reporting margins in the limb salvage sarcoma literature. Of most concern was over 1/3 of clinical reports of oncologic outcomes did not include margin status, which substantially compromises any conclusions that readers may infer about treatment success, local recurrence, or survival. We believe there should be renewed efforts to encourage use of a common surgical margin reporting system that is simple, reproducible, and prognostic. PMID:26361463

H. Pylori as a predictor of marginal ulceration: A nationwide analysis.

PubMed

Schulman, Allison R; Abougergi, Marwan S; Thompson, Christopher C

2017-03-01

Helicobacter pylori has been implicated as a risk factor for development of marginal ulceration following gastric bypass, although studies have been small and yielded conflicting results. This study sought to determine the relationship between H. pylori infection and development of marginal ulceration following bariatric surgery in a nationwide analysis. This was a retrospective cohort study using the 2012 Nationwide Inpatient Sample (NIS) database. Discharges with ICD-9-CM code indicating marginal ulceration and a secondary ICD-9-CM code for bariatric surgery were included. Primary outcome was incidence of marginal ulceration. A stepwise forward selection model was used to build the multivariate logistic regression model based on known risk factors. A P value of 0.05 was considered significant. There were 253,765 patients who met inclusion criteria. Prevalence of marginal ulceration was 3.90%. Of those patients found to have marginal ulceration, 31.20% of patients were H. pylori-positive. Final multivariate regression analysis revealed that H. pylori was the strongest independent predictor of marginal ulceration. H. pylori is an independent predictor of marginal ulceration using a large national database. Preoperative testing for and eradication of H. pylori prior to bariatric surgery may be an important preventive measure to reduce the incidence of ulcer development. © 2017 The Obesity Society.

Quantifying the ventilatory control contribution to sleep apnoea using polysomnography.

PubMed

Terrill, Philip I; Edwards, Bradley A; Nemati, Shamim; Butler, James P; Owens, Robert L; Eckert, Danny J; White, David P; Malhotra, Atul; Wellman, Andrew; Sands, Scott A

2015-02-01

Elevated loop gain, consequent to hypersensitive ventilatory control, is a primary nonanatomical cause of obstructive sleep apnoea (OSA) but it is not possible to quantify this in the clinic. Here we provide a novel method to estimate loop gain in OSA patients using routine clinical polysomnography alone. We use the concept that spontaneous ventilatory fluctuations due to apnoeas/hypopnoeas (disturbance) result in opposing changes in ventilatory drive (response) as determined by loop gain (response/disturbance). Fitting a simple ventilatory control model (including chemical and arousal contributions to ventilatory drive) to the ventilatory pattern of OSA reveals the underlying loop gain. Following mathematical-model validation, we critically tested our method in patients with OSA by comparison with a standard (continuous positive airway pressure (CPAP) drop method), and by assessing its ability to detect the known reduction in loop gain with oxygen and acetazolamide. Our method quantified loop gain from baseline polysomnography (correlation versus CPAP-estimated loop gain: n=28; r=0.63, p<0.001), detected the known reduction in loop gain with oxygen (n=11; mean±sem change in loop gain (ΔLG) -0.23±0.08, p=0.02) and acetazolamide (n=11; ΔLG -0.20±0.06, p=0.005), and predicted the OSA response to loop gain-lowering therapy. We validated a means to quantify the ventilatory control contribution to OSA pathogenesis using clinical polysomnography, enabling identification of likely responders to therapies targeting ventilatory control. Copyright ©ERS 2015.

Quantifying the ventilatory control contribution to sleep apnoea using polysomnography

PubMed Central

Terrill, Philip I.; Edwards, Bradley A.; Nemati, Shamim; Butler, James P.; Owens, Robert L.; Eckert, Danny J.; White, David P.; Malhotra, Atul; Wellman, Andrew; Sands, Scott A.

2015-01-01

Elevated loop gain, consequent to hypersensitive ventilatory control, is a primary nonanatomical cause of obstructive sleep apnoea (OSA) but it is not possible to quantify this in the clinic. Here we provide a novel method to estimate loop gain in OSA patients using routine clinical polysomnography alone. We use the concept that spontaneous ventilatory fluctuations due to apnoeas/hypopnoeas (disturbance) result in opposing changes in ventilatory drive (response) as determined by loop gain (response/disturbance). Fitting a simple ventilatory control model (including chemical and arousal contributions to ventilatory drive) to the ventilatory pattern of OSA reveals the underlying loop gain. Following mathematical-model validation, we critically tested our method in patients with OSA by comparison with a standard (continuous positive airway pressure (CPAP) drop method), and by assessing its ability to detect the known reduction in loop gain with oxygen and acetazolamide. Our method quantified loop gain from baseline polysomnography (correlation versus CPAP-estimated loop gain: n=28; r=0.63, p<0.001), detected the known reduction in loop gain with oxygen (n=11; mean±SEM change in loop gain (ΔLG) −0.23±0.08, p=0.02) and acetazolamide (n=11; ΔLG −0.20±0.06, p=0.005), and predicted the OSA response to loop gain-lowering therapy. We validated a means to quantify the ventilatory control contribution to OSA pathogenesis using clinical polysomnography, enabling identification of likely responders to therapies targeting ventilatory control. PMID:25323235

Economic Implications of Widespread Expansion of Frozen Section Margin Analysis to Guide Surgical Resection in Women With Breast Cancer Undergoing Breast-Conserving Surgery.

PubMed

Boughey, Judy C; Keeney, Gary L; Radensky, Paul; Song, Christine P; Habermann, Elizabeth B

2016-04-01

In the current health care environment, cost effectiveness is critically important in policy setting and care of patients. This study performed a health economic analysis to assess the implications to providers and payers of expanding the use of frozen section margin analysis to minimize reoperations for patients undergoing breast cancer lumpectomy. A health care economic impact model was built to assess annual costs associated with breast lumpectomy procedures with and without frozen section margin analysis to avoid reoperation. If frozen section margin analysis is used in 20% of breast lumpectomies and under a baseline assumption that 35% of initial lumpectomies without frozen section analysis result in reoperations, the potential annual cost savings are $18.2 million to payers and $0.4 million to providers. Under the same baseline assumption, if 100% of all health care facilities adopted the use of frozen section margin analysis for breast lumpectomy procedures, the potential annual cost savings are $90.9 million to payers and $1.8 million to providers. On the basis of 10,000 simulations, use of intraoperative frozen section margin analysis yields cost saving for payers and is cost neutral to slightly cost saving for providers. This economic analysis indicates that widespread use of frozen section margin evaluation intraoperatively to guide surgical resection in breast lumpectomy cases and minimize reoperations would be beneficial to cost savings not only for the patient but also for payers and, in most cases, for providers. Copyright © 2016 by American Society of Clinical Oncology.

Marginal Pricing and Student Investment in Higher Education

ERIC Educational Resources Information Center

Hemelt, Steven W.; Stange, Kevin M.

2016-01-01

This paper examines the effect of marginal price on students' educational investments using rich administrative data on students at Michigan public universities. Marginal price refers to the amount colleges charge for each additional credit taken in a semester. Institutions differ in how they price credits above the full-time minimum (of 12…

Microleakage of Four Dental Cements in Metal Ceramic Restorations With Open Margins.

PubMed

Eftekhar Ashtiani, Reza; Farzaneh, Babak; Azarsina, Mohadese; Aghdashi, Farzad; Dehghani, Nima; Afshari, Aisooda; Mahshid, Minu

2015-11-01

Fixed prosthodontics is a routine dental treatment and microleakage is a major cause of its failure. The aim of this study was to assess the marginal microleakage of four cements in metal ceramic restorations with adapted and open margins. Sixty sound human premolars were selected for this experimental study performed in Tehran, Iran and prepared for full-crown restorations. Wax patterns were formed leaving a 300 µm gap on one of the proximal margins. The crowns were cast and the samples were randomly divided into four groups based on the cement used. Copings were cemented using zinc phosphate cement (Fleck), Fuji Plus resin-modified glass ionomer, Panavia F2.0 resin cement, or G-Cem resin cement, according to the manufacturers' instructions. Samples were immersed in 2% methylene blue solution. After 24 hours, dye penetration was assessed under a stereomicroscope and analyzed using the respective software. Data were analyzed using ANOVA, paired t-tests, and Kruskal-Wallis, Wilcoxon, and Mann-Whitney tests. The least microleakage occurred in the Panavia F2.0 group (closed margin, 0.18 mm; open margin, 0.64 mm) and the maximum was observed in the Fleck group (closed margin, 1.92 mm; open margin, 3.32 mm). The Fleck group displayed significantly more microleakage compared to the Fuji Plus and Panavia F2.0 groups (P < 0.001) in both closed and open margins. In open margins, differences in microleakage between the Fuji Plus and G-Cem as well as between the G-Cem and Panavia F2.0 groups were significant (P < 0.001). In closed margins, only the G-Cem group displayed significantly more microleakage as compared to the Panavia F2.0 group (P < 0.05). Paired t-test results showed significantly more microleakage in open margins compared to closed margins, except in the Fuji Plus group (P = 0.539). Fuji Plus cement exhibited better sealing ability in closed and open margins compared to G-Cem and Fleck cements. When using G-Cem and Fleck cements for full metal ceramic

30 CFR 204.4 - What is a marginal property under this part?

Code of Federal Regulations, 2010 CFR

2010-07-01

... 30 Mineral Resources 2 2010-07-01 2010-07-01 false What is a marginal property under this part... REVENUE MANAGEMENT ALTERNATIVES FOR MARGINAL PROPERTIES General Provisions § 204.4 What is a marginal property under this part? (a) To qualify as a marginal property eligible for royalty prepayment or...

Marginal regression models for clustered count data based on zero-inflated Conway-Maxwell-Poisson distribution with applications.

PubMed

Choo-Wosoba, Hyoyoung; Levy, Steven M; Datta, Somnath

2016-06-01

Community water fluoridation is an important public health measure to prevent dental caries, but it continues to be somewhat controversial. The Iowa Fluoride Study (IFS) is a longitudinal study on a cohort of Iowa children that began in 1991. The main purposes of this study (http://www.dentistry.uiowa.edu/preventive-fluoride-study) were to quantify fluoride exposures from both dietary and nondietary sources and to associate longitudinal fluoride exposures with dental fluorosis (spots on teeth) and dental caries (cavities). We analyze a subset of the IFS data by a marginal regression model with a zero-inflated version of the Conway-Maxwell-Poisson distribution for count data exhibiting excessive zeros and a wide range of dispersion patterns. In general, we introduce two estimation methods for fitting a ZICMP marginal regression model. Finite sample behaviors of the estimators and the resulting confidence intervals are studied using extensive simulation studies. We apply our methodologies to the dental caries data. Our novel modeling incorporating zero inflation, clustering, and overdispersion sheds some new light on the effect of community water fluoridation and other factors. We also include a second application of our methodology to a genomic (next-generation sequencing) dataset that exhibits underdispersion. © 2015, The International Biometric Society.

The Fallacy of Quantifying Risk

DTIC Science & Technology

2012-09-01

Defense AT&L: September–October 2012 18 The Fallacy of Quantifying Risk David E. Frick, Ph.D. Frick is a 35-year veteran of the Department of...a key to risk analysis was “choosing the right technique” of quantifying risk . The weakness in this argument stems not from the assertion that one...of information about the enemy), yet achiev- ing great outcomes. Attempts at quantifying risk are not, in and of themselves, objectionable. Prudence

Systematic reviews: I. The correlation between laboratory tests on marginal quality and bond strength. II. The correlation between marginal quality and clinical outcome.

PubMed

Heintze, Siegward D

2007-01-01

An accepted principle in restorative dentistry states that restorations should be placed with the best marginal quality possible to avoid postoperative sensitivity, marginal discoloration, and secondary caries. Different laboratory methods claim to predict the clinical performance of restorative materials, for example, tests of bond strength and microleakage and gap analysis. The purpose of this review was twofold: (1) find studies that correlated the results of bond strength tests with either microleakage or gap analysis for the same materials, and (2) find studies that correlated the results of microleakage and/or gaps with the clinical parameters for the same materials. Furthermore, influencing factors on the results of the laboratory tests were reviewed and assessed. For the first question, searches for studies were conducted in the MEDLINE database and IADR/AADR abtracts online with specific search and inclusion criteria. The outcome for each study was assessed on the basis of the statistical test applied in the study, and finally the number of studies with or without correlation was compiled. For the second question, results of the quantitative marginal analysis of Class V restorations published by the University of Zürich with the same test protocol and prospective clinical trials were searched that investigated the same materials for at least 2 years in Class V cavities. Pearson correlation coefficients were calculated for pooled data of materials and clinical outcome parameters such as retention loss, marginal discoloration, marginal integrity, and secondary caries. For the correlation of dye penetration and clinical outcome, studies on Class V restorations published by the same research institute were searched in MEDLINE that examined the same adhesive systems as the selected clinical trials. For the correlation bond strength/microleakage, 30 studies were included into the review, and for the correlation bond strength/gap analysis 18 studies. For both

Influence of Cavity Margin Design and Restorative Material on Marginal Quality and Seal of Extended Class II Resin Composite Restorations In Vitro.

PubMed

Soliman, Sebastian; Preidl, Reinhard; Karl, Sabine; Hofmann, Norbert; Krastl, Gabriel; Klaiber, Bernd

2016-01-01

To investigate the influence of three cavity designs on the marginal seal of large Class II cavities restored with low-shrinkage resin composite limited to the enamel. One hundred twenty (120) intact human molars were randomly divided into 12 groups, with three different cavity designs: 1. undermined enamel, 2. box-shaped, and 3. proximal bevel. The teeth were restored with 1. an extra-low shrinkage (ELS) composite free of diluent monomers, 2. microhybrid composite (Herculite XRV), 3. nanohybrid composite (Filtek Supreme XTE), and 4. silorane-based composite (Filtek Silorane). After artificial aging by thermocycling and storage in physiological saline, epoxy resin replicas were prepared. To determine the integrity of the restorations' approximal margins, two methods were sequentially employed: 1. replicas were made of the 120 specimens and examined using SEM, and 2. the same 120 specimens were immersed in AgNO3 solution, and the dye penetration depth was observed with a light microscope. Statistical analysis was performed using the Kruskal-Wallis and the Dunn-Bonferroni tests. After bevel preparation, SEM observations showed that restorations did not exhibit a higher percentage of continuous margin (SEM-analysis; p>0.05), but more leakage was found than with the other cavity designs (p<0.05). The lowest percentage of continuous margin was observed in ELS restorations (p<0.05). More fractured margins were observed in the undermined enamel cavity design groups (p<0.05). Bevel preparation failed to improve margin quality in large Class II composite restorations and is no longer recommended. However, undermined enamel should be removed to prevent enamel fractures.

The Cadiz margin study off Spain: An introduction

USGS Publications Warehouse

Nelson, C.H.; Maldonado, A.

1999-01-01

The Cadiz continental margin of the northeastern Gulf of Cadiz off Spain was selected for a multidisciplinary project because of the interplay of complex tectonic history between the Iberian and African plates, sediment supply from multiple sources, and unique Mediterranean Gateway inflow and outflow currents. The nature of this complex margin, particularly during the last 5 million years, was investigated with emphasis on tectonic history, stratigraphic sequences, marine circulation, contourite depositional facies, geotechnical properties, geologic hazards, and human influences such as dispersal of river contaminants. This study provides an integrated view of the tectonic, sediment supply and oceanographic factors that control depositional processes and growth patterns of the Cadiz and similar modem and ancient continental margins.

Pedagogy of the Anxious: Rethinking Critical Pedagogy in the Context of Neoliberal Autonomy and Responsibilization

ERIC Educational Resources Information Center

De Lissovoy, Noah

2018-01-01

Critical pedagogy, and the work of Paulo Freire in particular, understands the struggle for emancipation as involving the emergence, as historical subjects, of those who have been marginalized. In this regard, this tradition could be said to foreground a "politics of the subject" as central to its philosophy. However, scholars of…

Building "Consciousness and Legacies": Integrating Community, Critical, and Classical Knowledge Bases in a Precalculus Class

ERIC Educational Resources Information Center

Gutierrez, Rodrigo Jorge

2013-01-01

Grounded in Freire's (1970) notion that the purpose of education in an unjust society is to bring about equality and justice, Critical Mathematics (CM) scholars consider mathematics to be a tool to understand, critique, and change the world by deconstructing power structures that marginalize certain groups. In particular, Gutstein's (2006)…

MRI Evaluation of Resection Margins in Bone Tumour Surgery

PubMed Central

Traore, Sidi Yaya; Lecouvet, Frédéric; Galant, Christine

2014-01-01

In 12 patients operated on for bone sarcoma resection, a postoperative magnetic resonance imaging of the resection specimens was obtained in order to assess the surgical margins. Margins were classified according to MRI in R0, R1, and R2 by three independent observers: a radiologist and two orthopaedic surgeons. Final margin evaluation (R0, R1, and R2) was assessed by a confirmed pathologist. Agreement for margin evaluation between the pathologist and the radiologist was perfect (κ = 1). Agreement between the pathologist and an experienced orthopaedic surgeon was very good while it was fair between the pathologist and a junior orthopaedic surgeon. MRI should be considered as a tool to give quick information about the adequacy of margins and to help the pathologist to focus on doubtful areas and to spare time in specimen analysis. But it may not replace the pathological evaluation that gives additional information about tumor necrosis. This study shows that MRI extemporaneous analysis of a resection specimen may be efficient in bone tumor oncologic surgery, if made by an experienced radiologist with perfect agreement with the pathologist. PMID:24976785

Marginal revenue and length of stay in inpatient psychiatry.

PubMed

Pletscher, Mark

2016-09-01

This study examines the changes in marginal revenue during psychiatric inpatient stays in a large Swiss psychiatric hospital after the introduction of a mixed reimbursement system with tariff rates that vary over length of stay. A discrete time duration model with a difference-in-difference specification and time-varying coefficients is estimated to assess variations in policy effects over length of stay. Among patients whose costs are fully reimbursed by the mixed scheme, the model demonstrates a significant effect of marginal revenue on length of stay. No significant policy effects are found among patients for whom only health insurance rates are delivered as mixed tariffs and government contributions are made retrospectively. The results indicate that marginal revenue can affect length of stay in inpatient psychiatry facilities, but that the reduction in marginal revenue must be sufficiently large.

Marginalization and School Nursing

ERIC Educational Resources Information Center

Smith, Julia Ann

2004-01-01

The concept of marginalization was first analyzed by nursing researchers Hall, Stevens, and Meleis. Although nursing literature frequently refers to this concept when addressing "at risk" groups such as the homeless, gays and lesbians, and those infected with HIV/AIDS, the concept can also be applied to nursing. Analysis of current school nursing…

Along-strike supply of volcanic rifted margins: Implications for plume-influenced rifting and sudden along-strike transitions between volcanic and non-volcanic rifted margins

NASA Astrophysics Data System (ADS)

Ranero, C. R.; Phipps Morgan, J.

2006-12-01

The existence of sudden along-strike transitions between volcanic and non-volcanic rifted margins is an important constraint for conceptual models of rifting and continental breakup. We think there is a promising indirect approach to infer the maximum width of the region of upwelling that exists beneath a rifted margin during the transition from rifting to seafloor-spreading. We infer this width of ~30km from the minimum length of the ridge-offsets that mark the limits of the `region of influence' of on-ridge plumes on the axial relief, axial morphology, and crustal thickness along the ridge and at the terminations of fossil volcanic rifted margins. We adopt Vogt's [1972] hypothesis for along-ridge asthenospheric flow in a narrow vertical slot beneath the axis of plume-influenced `macro-segments' and volcanic rifted margins. We find that: (1) There is a threshold distance to the lateral offsets that bound plume-influenced macrosegments; all such `barrier offsets' are greater than ~30km, while smaller offsets do not appear to be a barrier to along-axis flow. This pattern is seen in the often abrupt transitions between volcanic and non-volcanic rifted margins; these transitions coincide with >30km ridge offsets that mark the boundary between the smooth seafloor morphology and thick crust of a plume- influenced volcanic margin and a neighboring non-volcanic margin, as recorded in 180Ma rifting of the early N. Atlantic, the 42Ma rifting of the Kerguelen-Broken Ridge, and the 66Ma Seychelles-Indian rifting in the Indian Ocean. (2) A similar pattern is seen in the often abrupt transitions between `normal' and plume-influenced mid- ocean ridge segments, which is discussed in a companion presentation by Phipps Morgan and Ranero (this meeting). (3) The coexistance of adjacent volcanic and non-volcanic rifted margin segments is readily explained in this conceptual framework. If the volcanic margin macrosegment is plume-fed by hot asthenosphere along an axial ridge slot

Consequences of the presence of a weak fault on the stress and strain within an active margin

NASA Astrophysics Data System (ADS)

Conin, M.; Henry, P.; Godard, V.; Bourlange, S.

2009-12-01

Accreting margins often display an outer thrust and fold belt and an inner forearc domain overlying the subduction plate. Assuming that this overlying material behaves as Coulomb material, the outer wedge and the inner wedge are classically approximated as a critical state and a stable state Coulomb wedge, respectively. Critical Coulomb wedge theory can account for the transition from wedge to forearc. However, it cannot be used to determine the state of stress in the transition zone, nor the consequences of a discontinuity within the margin. The presence of a discontinuity such as a splay fault having a low effective friction coefficient should affect the stress state within the wedge, at least locally around the splay fault. Moreover, the effective friction coefficient of the seismogenic zone is expected to vary during the seismic cycle, and this may influence the stability of the Coulomb wedges. We use the ADELI finite element code (Chery and Hassani, 2000) to model the quasi-static stress and strain of a decollement and splay fault system, within a two dimensional elasto-plastic wedge with Drucker-Prager rheology. The subduction plane, the basal decollement of the accretionary wedge and the splay fault are modeled with contact elements. The modeled margin comprises an inner and an outer domain with distinct tapers and basal friction coefficients. For a given splay fault geometry, we evaluate the friction coefficient threshold for splay fault activation as a function of the basal friction coefficients, and examine the consequences of motion along the splay fault on stress and strain within the wedge and on the surface slope at equilibrium. Friction coefficients are varied in time to mimic the consequence of the seismic cycle on the static stress state and strain distribution. Results show the possibility of coexistence of localized extensional regime above the splay fault within a regional compressional regime. Such coexistence is consistent with stress

Critical Questions for Space Human Factors

NASA Technical Reports Server (NTRS)

Woolford, Barbara; Bagian, Tandi

2000-01-01

Traditional human factors contributions to NASA's crewed space programs have been rooted in the classic approaches to quantifying human physical and cognitive capabilities and limitations in the environment of interest, and producing recommendations and standards for the selection or design of mission equipment. Crews then evaluate the interfaces, displays, or equipment, and with the assistance of human factors experts, improvements are made as funds, time, control documentation, and weight allow. We have come a long way from the early spaceflight days, where men with the ' right stuff were the solution to operating whatever equipment was given to them. The large and diverse Shuttle astronaut corps has impacted mission designs to accommodate a wide range of human capabilities and preferences. Yet with existing long duration experience, we have seen the need to address a different set of dynamics when designing for optimal crew performance: critical equipment and mission situations degrade, and human function changes with mission environment, situation, and duration. Strategies for quantifying the critical nature of human factors requirements are being worked by NASA. Any exploration-class mission will place new responsibilities on mission designers to provide the crew with the information and resources to accomplish the mission. The current duties of a Mission Control Center to monitor system status, detect degradation or malfunction, and provide a proven solution, will need to be incorporated into on-board systems to allow the crew autonomous decision-making. The current option to resupply and replace mission systems and resources, including both vehicle equipment and human operators, will be removed, so considerations of maintenance, onboard training, and proficiency assessment are critical to providing a self-sufficient crew. As we 'move in' to the International Space Station, there are tremendous opportunities to investigate our ability to design for autonomous

In vitro Evaluation of the Marginal Fit and Internal Adaptation of Zirconia and Lithium Disilicate Single Crowns: Micro-CT Comparison Between Different Manufacturing Procedures.

PubMed

Riccitiello, Francesco; Amato, Massimo; Leone, Renato; Spagnuolo, Gianrico; Sorrentino, Roberto

2018-01-01

Prosthetic precision can be affected by several variables, such as restorative materials, manufacturing procedures, framework design, cementation techniques and aging. Marginal adaptation is critical for long-term longevity and clinical success of dental restorations. Marginal misfit may lead to cement exposure to oral fluids, resulting in microleakage and cement dissolution. As a consequence, marginal discrepancies enhance percolation of bacteria, food and oral debris, potentially causing secondary caries, endodontic inflammation and periodontal disease. The aim of the present in vitro study was to evaluate the marginal and internal adaptation of zirconia and lithium disilicate single crowns, produced with different manufacturing procedures. Forty-five intact human maxillary premolars were prepared for single crowns by means of standardized preparations. All-ceramic crowns were fabricated with either CAD-CAM or heat-pressing procedures (CAD-CAM zirconia, CAD-CAM lithium disilicate, heat-pressed lithium disilicate) and cemented onto the teeth with a universal resin cement. Non-destructive micro-CT scanning was used to achieve the marginal and internal gaps in the coronal and sagittal planes; then, precision of fit measurements were calculated in a dedicated software and the results were statistically analyzed. The heat-pressed lithium disilicate crowns were significantly less accurate at the prosthetic margins (p<0.05) while they performed better at the occlusal surface ( p <0.05). No significant differences were noticed between CAD-CAM zirconia and lithium disilicate crowns ( p >0.05); nevertheless CAD-CAM zirconia copings presented the best marginal fit among the experimental groups. As to the thickness of the cement layer, reduced amounts of luting agent were noticed at the finishing line, whereas a thicker layer was reported at the occlusal level. Within the limitations of the present in vitro investigation, the following conclusions can be drawn: the recorded

Application of matrix singular value properties for evaluating gain and phase margins of multiloop systems. [stability margins for wing flutter suppression and drone lateral attitude control

NASA Technical Reports Server (NTRS)

Mukhopadhyay, V.; Newsom, J. R.

1982-01-01

A stability margin evaluation method in terms of simultaneous gain and phase changes in all loops of a multiloop system is presented. A universal gain-phase margin evaluation diagram is constructed by generalizing an existing method using matrix singular value properties. Using this diagram and computing the minimum singular value of the system return difference matrix over the operating frequency range, regions of guaranteed stability margins can be obtained. Singular values are computed for a wing flutter suppression and a drone lateral attitude control problem. The numerical results indicate that this method predicts quite conservative stability margins. In the second example if the eigenvalue magnitude is used instead of the singular value, as a measure of nearness to singularity, more realistic stability margins are obtained. However, this relaxed measure generally cannot guarantee global stability.

The lid wiper and muco-cutaneous junction anatomy of the human eyelid margins: an in vivo confocal and histological study

PubMed Central

Knop, Erich; Knop, Nadja; Zhivov, Andrey; Kraak, Robert; Korb, Donald R; Blackie, Caroline; Greiner, Jack V; Guthoff, Rudolf

2011-01-01

The inner border of the eyelid margin is critically important for ocular surface integrity because it guarantees the thin spread of the tear film. Its exact morphology in the human is still insufficiently known. The histology in serial sections of upper and lower lid margins in whole-mount specimens from 10 human body donors was compared to in vivo confocal microscopy of eight eyes with a Heidelberg retina-tomograph (HRT II) and attached Rostock cornea module. Behind the posterior margin of the Meibomian orifices, the cornified epidermis stopped abruptly and was replaced by a continuous layer of para-keratinized (pk) cells followed by discontinuous pk cells. The pk cells covered the muco-cutaneous junction (MCJ), the surface of which corresponded to the line of Marx (0.2–0.3 mm wide). Then a stratified epithelium with a conjunctival structure of cuboidal cells, some pk cells, and goblet cells formed an epithelial elevation of typically about 100 μm initial thickness (lid wiper). This continued for 0.3–1.5 mm and formed a slope. The MCJ and lid wiper extended all along the lid margin from nasal to temporal positions in the upper and lower lids. Details of the epithelium and connective tissue were also detectable using the Rostock cornea module. The human inner lid border has distinct zones. Due to its location and morphology, the epithelial lip of the lid wiper appears a suitable structure to spread the tear film and is distinct from the MCJ/line of Marx. Better knowledge of the lid margin appears important for understanding dry eye disease and its morphology can be analysed clinically by in vivo confocal microscopy. PMID:21413985

Independent Predictors of Prognosis Based on Oral Cavity Squamous Cell Carcinoma Surgical Margins.

PubMed

Buchakjian, Marisa R; Ginader, Timothy; Tasche, Kendall K; Pagedar, Nitin A; Smith, Brian J; Sperry, Steven M

2018-05-01

Objective To conduct a multivariate analysis of a large cohort of oral cavity squamous cell carcinoma (OCSCC) cases for independent predictors of local recurrence (LR) and overall survival (OS), with emphasis on the relationship between (1) prognosis and (2) main specimen permanent margins and intraoperative tumor bed frozen margins. Study Design Retrospective cohort study. Setting Tertiary academic head and neck cancer program. Subjects and Methods This study included 426 patients treated with OCSCC resection between 2005 and 2014 at University of Iowa Hospitals and Clinics. Patients underwent excision of OCSCC with intraoperative tumor bed frozen margin sampling and main specimen permanent margin assessment. Multivariate analysis of the data set to predict LR and OS was performed. Results Independent predictors of LR included nodal involvement, histologic grade, and main specimen permanent margin status. Specifically, the presence of a positive margin (odds ratio, 6.21; 95% CI, 3.3-11.9) or <1-mm/carcinoma in situ margin (odds ratio, 2.41; 95% CI, 1.19-4.87) on the main specimen was an independent predictor of LR, whereas intraoperative tumor bed margins were not predictive of LR on multivariate analysis. Similarly, independent predictors of OS on multivariate analysis included nodal involvement, extracapsular extension, and a positive main specimen margin. Tumor bed margins did not independently predict OS. Conclusion The main specimen margin is a strong independent predictor of LR and OS on multivariate analysis. Intraoperative tumor bed frozen margins do not independently predict prognosis. We conclude that emphasis should be placed on evaluating the main specimen margins when estimating prognosis after OCSCC resection.

The Blake Nose Cretaceous-Paleogene (Florida Atlantic margin, ODP Leg 171B): an exemplar record of the Maastrichtian-Danian transition

USGS Publications Warehouse

Bellier, J.-P.; Marca, S.; Norris, R.D.; Kroon, D.; Klaus, A.; Alexander, I.T.; Bardot, L.P.; Barker, C.E.; Blome, C.D.; Clarke, L.J.; Erbacher, J.; Faul, K.L.; Holmes, M.A.; Huber, B.T.; Katz, M.E.; MacLeod, K.G.; Martinez-Ruiz, F. C.; Mita, I.; Nakai, M.; Ogg, James G.; Pak, D.K.; Pletsch, T.K.; ,; Shackleton, N.J.; Smit, J.; Ussler, W.; Watkins, D.K.; Widmark, J.; Wilson, P.A.

1997-01-01

During ODP Leg 171B, devoted to the analysis of the Blake Plateau margin in front of Florida, 16 holes have been drilled in 5 distinct sites. The sites have documented a sedimentary succession ranging in age from Aptian to Eocene. Emphasis has been put on critical periods, comprising the Paleocene-Eocene transition, the Cretaceous-Tertiary boundary which has been cored in excellent conditions, the middle Maastrichtian extinctions and the Albian anoxic episodes.

Small cell lymphocytic variant of marginal zone lymphoma: A distinct form of marginal zone lymphoma derived from naïve B cells as a cutaneous counterpart to the naïve marginal zone lymphoma of splenic origin.

PubMed

Magro, Cynthia M; Olson, Luke C

2018-02-21

Primary cutaneous marginal zone lymphoma most commonly represents an indolent form of cutaneous B cell lymphoma. However, epidermotropic marginal zone lymphoma, blastic marginal zone lymphoma and B cell dominant variants without isotype switching can be associated with extracutaneous dissemination. The presumptive cell of origin is a post germinal center B cell with plasmacytic features. In the extracutaneous setting, however, a naïve B cell origin has been proposed for a subset of marginal zone lymphomas, notably splenic marginal zone lymphoma. The author encountered 11 cases of atypical lymphocytic infiltration of the skin primarily occurring in older individuals with an upper arm and head and neck localization; there was a reproducible pattern of diffuse and nodular infiltration by small monomorphic-appearing B cells. Phenotypically, the infiltrate was one predominated by B cells exhibiting CD23 and IgD positivity without immunoreactivity for CD38 and there were either no plasma cells or only a few without light chain restriction. In cases presenting with a solitary lesion complete excision and/or radiation led to successful disease remission in all cases without recurrence or metastatic disease. Of three cases with multiple initial lesions, evidence of extracutaneous disease was seen in two cases and recurrence occurred in one case. No patients have died of lymphoma. Longer term follows up and additional cases are needed to determine if this subset of marginal zone lymphoma is associated with a worse prognosis. Copyright © 2018. Published by Elsevier Inc.

Hydrothermal mineralising systems as critical systems

NASA Astrophysics Data System (ADS)

Hobbs, Bruce

2015-04-01

Hydrothermal mineralising systems as critical systems. Bruce E Hobbs1,2, Alison Ord1 and Mark A. Munro1. 1. Centre for Exploration Targeting, The University of Western Australia, M006, 35 Stirling Highway, Crawley, WA 6009, Australia. 2. CSIRO Earth and Resource Engineering, Bentley, WA, Australia Hydrothermal mineralising systems are presented as large, open chemical reactors held far from equilibrium during their life-time by the influx of heat, fluid and dissolved chemical species. As such they are nonlinear dynamical systems and need to be analysed using the tools that have been developed for such systems. Hydrothermal systems undergo a number of transitions during their evolution and this paper focuses on methods for characterising these transitions in a quantitative manner and establishing whether they resemble first or second (critical) phase transitions or whether they have some other kind of nature. Critical phase transitions are characterised by long range correlations for some parameter characteristic of the system, power-law probability distributions so that there is no characteristic length scale and a high sensitivity to perturbations; as one approaches criticality, characteristic parameters for the system scale in a power law manner with distance from the critical point. The transitions undergone in mineralised hydrothermal systems are: (i) widespread, non-localised mineral alteration involving exothermic mineral reactions that produce hydrous silicate phases, carbonates and iron-oxides, (ii) strongly localised veining, brecciation and/or stock-work formation, (iii) a series of endothermic mineral reactions involving the formation of non-hydrous silicates, sulphides and metals such as gold, (iv) multiple repetitions of transitions (ii) and (iii). We have quantified aspects of these transitions in gold deposits from the Yilgarn craton of Western Australia using wavelet transforms. This technique is convenient and fast. It enables one to establish if

It's Not My Party: A Critical Analysis of Women and Minority Opposition towards STEM

ERIC Educational Resources Information Center

Martin, David C.

2016-01-01

The civil rights era promised an invitation for equity and equality in education was on its way. The invitation was lost in the mail or it is a party that the "marginalized" do not want to attend. In 2004, the National Science Board (NSB) identified a critical shortage of workers in Science, Technology, Engineering, and Mathematics…

Radiobiological impact of reduced margins and treatment technique for prostate cancer in terms of tumor control probability (TCP) and normal tissue complication probability (NTCP).

PubMed

Jensen, Ingelise; Carl, Jesper; Lund, Bente; Larsen, Erik H; Nielsen, Jane

2011-01-01

Dose escalation in prostate radiotherapy is limited by normal tissue toxicities. The aim of this study was to assess the impact of margin size on tumor control and side effects for intensity-modulated radiation therapy (IMRT) and 3D conformal radiotherapy (3DCRT) treatment plans with increased dose. Eighteen patients with localized prostate cancer were enrolled. 3DCRT and IMRT plans were compared for a variety of margin sizes. A marker detectable on daily portal images was presupposed for narrow margins. Prescribed dose was 82 Gy within 41 fractions to the prostate clinical target volume (CTV). Tumor control probability (TCP) calculations based on the Poisson model including the linear quadratic approach were performed. Normal tissue complication probability (NTCP) was calculated for bladder, rectum and femoral heads according to the Lyman-Kutcher-Burman method. All plan types presented essentially identical TCP values and very low NTCP for bladder and femoral heads. Mean doses for these critical structures reached a minimum for IMRT with reduced margins. Two endpoints for rectal complications were analyzed. A marked decrease in NTCP for IMRT plans with narrow margins was seen for mild RTOG grade 2/3 as well as for proctitis/necrosis/stenosis/fistula, for which NTCP <7% was obtained. For equivalent TCP values, sparing of normal tissue was demonstrated with the narrow margin approach. The effect was more pronounced for IMRT than 3DCRT, with respect to NTCP for mild, as well as severe, rectal complications. Copyright © 2011 American Association of Medical Dosimetrists. Published by Elsevier Inc. All rights reserved.

Safety margins in the implementation of planetary quarantine requirements

NASA Technical Reports Server (NTRS)

Schalkowsky, S.; Jacoby, I.

1972-01-01

The formulation of planetary quarantine requirements, and their implementation as determined by a risk allocation model, is discussed. The model defines control safety margins with particular emphasis on utility in achieving the desired minimization of excessive margins, and their effect on implementation procedures.

The Effects of Marginal Deviations on Behavioral Development.

PubMed

Caprara, Gian Vittorio; Dodge, Kenneth A; Pastorelli, Concetta; Zelli, Arnaldo

2006-01-01

This investigation was conceptually framed within the theory of marginal deviations (Caprara & Zimbardo, 1996) and sought evidence for the general hypothesis that some children who initially show marginal behavioral problems may, over time, develop more serious problems depending partly on other personal and behavioral characteristics. To this end, the findings of two studies conducted, respectively, with American elementary school children and Italian middle school students are reviewed. These two studies show that hyperactivity, cognitive difficulties, low special preference, and lack of prosocial behavior increase a child's risk for growth in aggressive behavior over several school years. More importantly, they also show that equivalent levels of these risk factors have a greater impact on the development of children who, early on, were marginally aggressive.

Structure of the North American Atlantic Continental Margin

USGS Publications Warehouse

Schlee, J.S.; Klitgord, K.K.

1986-01-01

Off E N America, where the structure of the continental margin is essentially constructional, seismic profiles have approximated geologic cross sections up to 10-15km below the sea floor and revealed major structural and stratigraphic features that have regional hydrocarbon potential. These features include a) a block-faulted basement hinge zone; b) a deep, broad, rifted basement filled with clastic sediment and salt; and c) a buried paleoshelf-edge complex that has many forms. The mapping of seismostratigraphic units over the continental shelf, slope, and rise has shown that the margin's developmental state included infilling of a rifted margin, buildup of a carbonate platform, and construction of an onlapping continental-rise wedge that was accompanied by erosion of the slope. -from Authors

Marginal abatement cost curve for nitrogen oxides incorporating controls, renewable electricity, energy efficiency, and fuel switching.

PubMed

Loughlin, Daniel H; Macpherson, Alexander J; Kaufman, Katherine R; Keaveny, Brian N

2017-10-01

A marginal abatement cost curve (MACC) traces out the relationship between the quantity of pollution abated and the marginal cost of abating each additional unit. In the context of air quality management, MACCs are typically developed by sorting control technologies by their relative cost-effectiveness. Other potentially important abatement measures such as renewable electricity, energy efficiency, and fuel switching (RE/EE/FS) are often not incorporated into MACCs, as it is difficult to quantify their costs and abatement potential. In this paper, a U.S. energy system model is used to develop a MACC for nitrogen oxides (NO x ) that incorporates both traditional controls and these additional measures. The MACC is decomposed by sector, and the relative cost-effectiveness of RE/EE/FS and traditional controls are compared. RE/EE/FS are shown to have the potential to increase emission reductions beyond what is possible when applying traditional controls alone. Furthermore, a portion of RE/EE/FS appear to be cost-competitive with traditional controls. Renewable electricity, energy efficiency, and fuel switching can be cost-competitive with traditional air pollutant controls for abating air pollutant emissions. The application of renewable electricity, energy efficiency, and fuel switching is also shown to have the potential to increase emission reductions beyond what is possible when applying traditional controls alone.

In vitro evaluation of marginal adaptation in five ceramic restoration fabricating techniques.

PubMed

Ural, Cağri; Burgaz, Yavuz; Saraç, Duygu

2010-01-01

To compare in vitro the marginal adaptation of crowns manufactured using ceramic restoration fabricating techniques. Fifty standardized master steel dies simulating molars were produced and divided into five groups, each containing 10 specimens. Test specimens were fabricated with CAD/CAM, heat-press, glass-infiltration, and conventional lost-wax techniques according to manufacturer instructions. Marginal adaptation of the test specimens was measured vertically before and after cementation using SEM. Data were statistically analyzed by one-way ANOVA with Tukey HSD tests (a = .05). Marginal adaptation of ceramic crowns was affected by fabrication technique and cementation process (P < .001). The lowest marginal opening values were obtained with Cerec-3 crowns before and after cementation (P < .001). The highest marginal discrepancy values were obtained with PFM crowns before and after cementation. Marginal adaptation values obtained in the compared systems were within clinically acceptable limits. Cementation causes a significant increase in the vertical marginal discrepancies of the test specimens.

Quantifying reflexivity in financial markets: Toward a prediction of flash crashes

NASA Astrophysics Data System (ADS)

Filimonov, Vladimir; Sornette, Didier

2012-05-01

We introduce a measure of activity of financial markets that provides a direct access to their level of endogeneity. This measure quantifies how much of price changes is due to endogenous feedback processes, as opposed to exogenous news. For this, we calibrate the self-excited conditional Poisson Hawkes model, which combines in a natural and parsimonious way exogenous influences with self-excited dynamics, to the E-mini S&P 500 futures contracts traded in the Chicago Mercantile Exchange from 1998 to 2010. We find that the level of endogeneity has increased significantly from 1998 to 2010, with only 70% in 1998 to less than 30% since 2007 of the price changes resulting from some revealed exogenous information. Analogous to nuclear plant safety measures concerned with avoiding “criticality,” our measure provides a direct quantification of the distance of the financial market from a critical state defined precisely as the limit of diverging trading activity in the absence of any external driving.

On marginally resolved objects in optical interferometry

NASA Astrophysics Data System (ADS)

Lachaume, R.

2003-03-01

With the present and soon-to-be breakthrough of optical interferometry, countless objects shall be within reach of interferometers; yet, most of them are expected to remain only marginally resolved with hectometric baselines. In this paper, we tackle the problem of deriving the properties of a marginally resolved object from its optical visibilities. We show that they depend on the moments of flux distribution of the object: centre, mean angular size, asymmetry, and curtosis. We also point out that the visibility amplitude is a second-order phenomenon, whereas the phase is a combination of a first-order term, giving the location of the photocentre, and a third-order term, more difficult to detect than the visibility amplitude, giving an asymmetry coefficient of the object. We then demonstrate that optical visibilities are not a good model constraint while the object stays marginally resolved, unless observations are carried out at different wavelengths. Finally, we show an application of this formalism to circumstellar discs.

Scientific Ocean Drilling to Assess Submarine Geohazards along European Margins

NASA Astrophysics Data System (ADS)

Ask, M. V.; Camerlenghi, A.; Kopf, A.; Morgan, J. K.; Ocean DrillingSeismic Hazard, P. E.

2008-12-01

Submarine geohazards are some of the most devastating natural events in terms of lives lost and economic impact. Earthquakes pose a big threat to society and infrastructure, but the understanding of their episodic generation is incomplete. Tsunamis are known for their potential of striking coastlines world-wide. Other geohazards originating below the sea surface are equally dangerous for undersea structures and the coastal population: submarine landslides and volcanic islands collapse with little warning and devastating consequences. The European scientific community has a strong focus on geohazards along European and nearby continental margins, especially given their high population densities, and long historic and prehistoric record of hazardous events. For example, the Mediterranean is surrounded by very densely-populated coastline and is the World's leading holiday destination, receiving up 30% of global tourism. In addition, its seafloor is criss-crossed by hydrocarbon pipelines and telecommunication cables. However, the governing processes and recurrence intervals of geohazards are still poorly understood. Examples include, but are not limited to, earthquakes and volcanic eruptions along the active tectonic margins of the Mediterranean and Sea of Marmara, landslides on both active and passive margins, and tsunamites and seismites in the sedimentary record that suggest a long history of similar events. The development of geophysical networks, drilling, sampling and long-term monitoring are crucial to the understanding of earthquake, landslide, and tsunami processes, and to mitigate the associated risks in densely populated and industrialized regions such as Europe. Scientific drilling, particularly in the submarine setting, offers a unique tool to obtain drill core samples, borehole measurements and long-term observations. Hence, it is a critical technology to investigate past, present, and possible future influences of hazardous processes in this area. The

Clinical study of imaging skin cancer margins using polarized light imaging

NASA Astrophysics Data System (ADS)

Samatham, Ravikant; Lee, Ken; Jacques, Steven L.

2012-02-01

Skin cancer is most commons type of cancer in United States that occur on sun-exposed cosmetically sensitive areas like face, neck, and forearms. Surgical excision of skin cancer is challenging as more than one-third the actual margins extend beyond the clinically determined margins. Polarized light camera (polCAM) provides images of the superficial layers of the tissue with enhanced contrast which was used to image skin cancer margins. In a NIH-funded pilot study polCAM was used to image skin cancer in patients undergoing Mohs micrographic surgery for skin cancer. Polarized light imaging utilizes the polarization properties of light to create an image of a lesion comprised only of light scattering from the superficial layers of the skin which yields a characteristic "fabric pattern" of the putative lesion and the surrounding normal tissue. In several case studies conducted with a system developed for the clinic, we have found that skin cancer disrupts this fabric pattern, allowing the doctor a new means of identifying the margins of the lesion. Data is acquired before the patient underwent surgery. The clinically determined skin cancer margins were compared with margins determined by examination of the polCAM images. The true margins were provided by the dermatophathologist on examination of the frozen sections. Our initial data suggests that the contrast due to polarization changes associated with cancerous lesions can elucidate margins that were not recognized by the surgeon under normal conditions but were later confirmed by the pathologist.

Passive margins getting squeezed in the mantle convection vice

NASA Astrophysics Data System (ADS)

Yamato, Philippe; Husson, Laurent; Becker, Thorsten W.; Pedoja, Kevin

2013-12-01

margins often exhibit uplift, exhumation, and tectonic inversion. We speculate that the compression in the lithosphere gradually increased during the Cenozoic, as seen in the number of mountain belts found at active margins during that period. Less clear is how that compression increase affects passive margins. In order to address this issue, we design a 2-D viscous numerical model wherein a lithospheric plate rests above a weaker mantle. It is driven by a mantle conveyor belt, alternatively excited by a lateral downwelling on one side, an upwelling on the other side, or both simultaneously. The lateral edges of the plate are either free or fixed, representing the cases of free convergence, and collision (or slab anchoring), respectively. This distinction changes the upper mechanical boundary condition for mantle circulation and thus, the stress field. Between these two regimes, the flow pattern transiently evolves from a free-slip convection mode toward a no-slip boundary condition above the upper mantle. In the second case, the lithosphere is highly stressed horizontally and deforms. For a constant total driving force, compression increases drastically at passive margins if upwellings are active. Conversely, if downwellings alone are activated, compression occurs at short distances from the trench and extension prevails elsewhere. These results are supported by Earth-like models that reveal the same pattern, where active upwellings are required to excite passive margins compression. Our results substantiate the idea that compression at passive margins is in response to the underlying mantle flow that is increasingly resisted by the Cenozoic collisions.

3D thermal history and maturity modelling of the Levant Basin and Margin

NASA Astrophysics Data System (ADS)

Daher, Samer Bou; Ducros, Mathieu; Michel, Pauline; Nader, Fadi H.; Littke, Ralf

2015-04-01

The gas discoveries recorded in the Levant Basin in the last decade have redirected the industrial and academic communities' interest to this frontier basin and its surroundings. The reported gas in Miocene reservoirs has been assumed to be derived from biogenic sources, although little data has been published so far. The thickness of the sedimentary column and the presence of direct hydrocarbon indicators (DHI) observed in the seismic data suggest the presence of promising prospective thermogenic petroleum systems in deeper intervals in the Levant Basin and along its Margin. In this study we present a large scale 3D thermal history and maturity model of the Levant Basin and Margin, integrating all available calibration data, source rock information collected from onshore Lebanon, and published data. In the first part we will present the main input and assumptions that were made in terms of thicknesses, lithologies, and boundary conditions. In the second part we will discuss the analysed source rocks, their petroleum generation potential and their kinetics. In the third part we will present modelling results including depth maps for key isotherms in addition to transformation ratio and vitrinite reflectance maps for proven and speculative source rocks at different time steps. This will provide a comprehensive assessment of the potential thermogenic petroleum systems in the study area, and allow us to illustrate and discuss the differences between the basinal, marginal, and onshore part of the study area as well as the potential of the northern vis a vis the southern offshore Levant Basin. This model will also allow us to analyse the sensitivity of the system to the various poorly constrained parameters in frontier basins (e.g. crustal thickness, rifting phases, lithologies) and thus identify the most critical data to be collected for future exploration and de-risking strategies.

Toward real-time tumor margin identification in image-guided robotic brain tumor resection

NASA Astrophysics Data System (ADS)

Hu, Danying; Jiang, Yang; Belykh, Evgenii; Gong, Yuanzheng; Preul, Mark C.; Hannaford, Blake; Seibel, Eric J.

2017-03-01

For patients with malignant brain tumors (glioblastomas), a safe maximal resection of tumor is critical for an increased survival rate. However, complete resection of the cancer is hard to achieve due to the invasive nature of these tumors, where the margins of the tumors become blurred from frank tumor to more normal brain tissue, but in which single cells or clusters of malignant cells may have invaded. Recent developments in fluorescence imaging techniques have shown great potential for improved surgical outcomes by providing surgeons intraoperative contrast-enhanced visual information of tumor in neurosurgery. The current near-infrared (NIR) fluorophores, such as indocyanine green (ICG), cyanine5.5 (Cy5.5), 5-aminolevulinic acid (5-ALA)-induced protoporphyrin IX (PpIX), are showing clinical potential to be useful in targeting and guiding resections of such tumors. Real-time tumor margin identification in NIR imaging could be helpful to both surgeons and patients by reducing the operation time and space required by other imaging modalities such as intraoperative MRI, and has the potential to integrate with robotically assisted surgery. In this paper, a segmentation method based on the Chan-Vese model was developed for identifying the tumor boundaries in an ex-vivo mouse brain from relatively noisy fluorescence images acquired by a multimodal scanning fiber endoscope (mmSFE). Tumor contours were achieved iteratively by minimizing an energy function formed by a level set function and the segmentation model. Quantitative segmentation metrics based on tumor-to-background (T/B) ratio were evaluated. Results demonstrated feasibility in detecting the brain tumor margins at quasi-real-time and has the potential to yield improved precision brain tumor resection techniques or even robotic interventions in the future.

Lithosphere structure and subsidence evolution of the conjugate S-African and Argentine margins

NASA Astrophysics Data System (ADS)

Dressel, Ingo; Scheck-Wenderoth, Magdalena; Cacace, Mauro; Götze, Hans-Jürgen; Franke, Dieter

2016-04-01

The bathymetric evolution of the South Atlantic passive continental margins is a matter of debate. Though it is commonly accepted that passive margins experience thermal subsidence as a result of lithospheric cooling as well as load induced subsidence in response to sediment deposition it is disputed if the South Atlantic passive margins were affected by additional processes affecting the subsidence history after continental breakup. We present a subsidence analysis along the SW African margin and offshore Argentina and restore paleobathymetries to assess the subsidence evolution of the margin. These results are discussed with respect to mechanisms behind margin evolution. Therefore, we use available information about the lithosphere-scale present-day structural configuration of these margins as a starting point for the subsidence analysis. A multi 1D backward modelling method is applied to separate individual subsidence components such as the thermal- as well as the load induced subsidence and to restore paleobathymetries for the conjugate margins. The comparison of the restored paleobathymetries shows that the conjugate margins evolve differently: Continuous subsidence is obtained offshore Argentina whereas the subsidence history of the SW African margin is interrupted by phases of uplift. This differing results for both margins correlate also with different structural configurations of the subcrustal mantle. In the light of these results we discuss possible implications for uplift mechanisms.

Margin and sensitivity methods for security analysis of electric power systems

NASA Astrophysics Data System (ADS)

Greene, Scott L.

Reliable operation of large scale electric power networks requires that system voltages and currents stay within design limits. Operation beyond those limits can lead to equipment failures and blackouts. Security margins measure the amount by which system loads or power transfers can change before a security violation, such as an overloaded transmission line, is encountered. This thesis shows how to efficiently compute security margins defined by limiting events and instabilities, and the sensitivity of those margins with respect to assumptions, system parameters, operating policy, and transactions. Security margins to voltage collapse blackouts, oscillatory instability, generator limits, voltage constraints and line overloads are considered. The usefulness of computing the sensitivities of these margins with respect to interarea transfers, loading parameters, generator dispatch, transmission line parameters, and VAR support is established for networks as large as 1500 buses. The sensitivity formulas presented apply to a range of power system models. Conventional sensitivity formulas such as line distribution factors, outage distribution factors, participation factors and penalty factors are shown to be special cases of the general sensitivity formulas derived in this thesis. The sensitivity formulas readily accommodate sparse matrix techniques. Margin sensitivity methods are shown to work effectively for avoiding voltage collapse blackouts caused by either saddle node bifurcation of equilibria or immediate instability due to generator reactive power limits. Extremely fast contingency analysis for voltage collapse can be implemented with margin sensitivity based rankings. Interarea transfer can be limited by voltage limits, line limits, or voltage stability. The sensitivity formulas presented in this thesis apply to security margins defined by any limit criteria. A method to compute transfer margins by directly locating intermediate events reduces the total number

Bounded Linear Stability Margin Analysis of Nonlinear Hybrid Adaptive Control

NASA Technical Reports Server (NTRS)

Nguyen, Nhan T.; Boskovic, Jovan D.

2008-01-01

This paper presents a bounded linear stability analysis for a hybrid adaptive control that blends both direct and indirect adaptive control. Stability and convergence of nonlinear adaptive control are analyzed using an approximate linear equivalent system. A stability margin analysis shows that a large adaptive gain can lead to a reduced phase margin. This method can enable metrics-driven adaptive control whereby the adaptive gain is adjusted to meet stability margin requirements.

Marginal Fit Comparison of CAD/CAM Crowns Milled from Two Different Materials.

PubMed

Azarbal, Atousa; Azarbal, Mohsen; Engelmeier, Robert L; Kunkel, Thomas C

2018-06-01

To evaluate the marginal fit of CAD/CAM copings milled from hybrid ceramic (Vita Enamic) blocks and lithium disilicate (IPS e.max CAD) blocks, and to evaluate the effect of crystallization firing on the marginal fit of lithium disilicate copings. A standardized metal die with a 1-mm-wide shoulder finish line was imaged using the CEREC AC Bluecam. The coping was designed using CEREC 3 software. The design was used to fabricate 15 lithium disilicate and 15 hybrid ceramic copings. Design and milling were accomplished by one operator. The copings were seated on the metal die using a pressure clamp with a uniform pressure of 5.5 lbs. A Macroview Microscope (14×) was used for direct viewing of the marginal gap. Four areas were imaged on each coping (buccal, distal, lingual, mesial). Image analysis software was used to measure the marginal gaps in μm at 15 randomly selected points on each of the four surfaces. A total of 60 measurements were made per specimen. For lithium disilicate copings the measurements for marginal gap were made before and after crystallization firing. Data were analyzed using paired t-test and Kruskal-Wallis test. The overall mean difference in marginal gap between the hybrid ceramic and crystallized lithium disilicate copings was statistically significant (p < 0.01). Greater mean marginal gaps were measured for crystallized lithium disilicate copings. The overall mean difference in marginal gap before and after firing (precrystallized and crystallized lithium disilicate copings) showed an average of 62 μm increase in marginal gap after firing. This difference was also significant (p < 0.01). A significant difference exists in the marginal gap discrepancy when comparing hybrid ceramic and lithium disilicate CAD/CAM crowns. Also crystallization firing can result in a significant increase in the marginal gap of lithium disilicate CAD/CAM crowns. © 2017 by the American College of Prosthodontists.

Brain death and marginal grafts in liver transplantation.

PubMed

Jiménez-Castro, M B; Gracia-Sancho, J; Peralta, C

2015-06-04

It is well known that most organs for transplantation are currently procured from brain-dead donors; however, the presence of brain death is an important risk factor in liver transplantation. In addition, one of the mechanisms to avoid the shortage of liver grafts for transplant is the use of marginal livers, which may show higher risk of primary non-function or initial poor function. To our knowledge, very few reviews have focused in the field of liver transplantation using brain-dead donors; moreover, reviews that focused on both brain death and marginal grafts in liver transplantation, both being key risk factors in clinical practice, have not been published elsewhere. The present review aims to describe the recent findings and the state-of-the-art knowledge regarding the pathophysiological changes occurring during brain death, their effects on marginal liver grafts and summarize the more controversial topics of this pathology. We also review the therapeutic strategies designed to date to reduce the detrimental effects of brain death in both marginal and optimal livers, attempting to explain why such strategies have not solved the clinical problem of liver transplantation.

Optical assessment of tumor resection margins in the breast

PubMed Central

Brown, J. Quincy; Bydlon, Torre M.; Richards, Lisa M.; Yu, Bing; Kennedy, Stephanie A.; Geradts, Joseph; Wilke, Lee G.; Junker, Marlee; Gallagher, Jennifer; Barry, William; Ramanujam, Nimmi

2011-01-01

Breast conserving surgery, in which the breast tumor and surrounding normal tissue are removed, is the primary mode of treatment for invasive and in situ carcinomas of the breast, conditions that affect nearly 200,000 women annually. Of these nearly 200,000 patients who undergo this surgical procedure, between 20–70% of them may undergo additional surgeries to remove tumor that was left behind in the first surgery, due to the lack of intra-operative tools which can detect whether the boundaries of the excised specimens are free from residual cancer. Optical techniques have many attractive attributes which may make them useful tools for intra-operative assessment of breast tumor resection margins. In this manuscript, we discuss clinical design criteria for intra-operative breast tumor margin assessment, and review optical techniques appied to this problem. In addition, we report on the development and clinical testing of quantitative diffuse reflectance imaging (Q-DRI) as a potential solution to this clinical need. Q-DRI is a spectral imaging tool which has been applied to 56 resection margins in 48 patients at Duke University Medical Center. Clear sources of contrast between cancerous and cancer-free resection margins were identified with the device, and resulted in an overall accuracy of 75% in detecting positive margins. PMID:21544237

Breast-conservative surgery followed by radiofrequency ablation of margins decreases the need for a second surgical procedure for close or positive margins.

PubMed

Rubio, Isabel T; Landolfi, Stefania; Molla, Meritxell; Cortes, Javier; Xercavins, Jordi

2014-10-01

Excision of breast cancer followed by radiofrequency ablation (eRFA) is a technique designed to increase negative margins in breast-conservative surgical procedures. The objective of this study is to analyze the impact of eRFA in avoiding a second surgical procedure for close or positive margins after a breast-conservative surgical procedure. From February 2008 to May 2010, 20 patients were included. After lumpectomy, the eRFA was performed in the lumpectomy cavity, and biopsies from each margin from the radial ablated cavity walls were obtained. Biopsy samples were assessed for tumor viability. eRFA was successful in 19 of 20 patients. In all patients, the devitalized tissue extended beyond a 5- to 10-mm radial depth of the biopsy sample. Overall, 6 patients (31%) had margins < 2 mm, 4 of them with < 1 mm margin. All 6 of these patients had no tumor viability according to analysis of biopsy samples stained with 2,3,5-triphenyltetrazolium chloride. At a median follow-up of 46 months, no local recurrence had been found. This study supports the feasibility of eRFA treatment. In our study, the eRFA method has spared 31% of patients from undergoing a re-excision surgical procedure, and it may, in the long-term, reduce local recurrences. Copyright © 2014 Elsevier Inc. All rights reserved.

The MIRROR cruise (2011): Deep crustal structure of the Moroccan Atlantic Margin from wide-angle and reflection seismic data

NASA Astrophysics Data System (ADS)

Klingelhoefer, F.; Aslanian, D.; Sahabi, M.; Moulin, M.; Schnurle, P.; Berglar, K.; Biari, Y.; Feld, A.; Graindorge, D.; Corela, C.; Mehdi, K.; Zourarah, B.; Perrot, J.; Alves Ribeiro, J.; Reichert, C. J.

2011-12-01

The study of conjugate margins is important to test different hypotheses of rifting and initial opening of an ocean. In this scope, seven wide-angle seismic profiles were acquired on the Moroccan Atlantic margin (at the latitudes between 32° and 33° N) together with coincident deep frequency reflection seismic data during the MIRROR cruise in May and June 2011. The main seismic profile is conjugate to an existing wide-angle seismic profile off Nova Scotia (SMART 2). Further objectives of the cruise were to image ocean-continent transition zone, to detect and eventually quantify exhumed upper mantle material present in this zone and to determine the origin of the high amplitude West African Magnetic Anomaly, which is conjugate to the north American East Coast Magnetic Anomaly and can be linked to the opening of the Atlantic. Two of the newly acquired profiles are located perpendicular and five parallel to the Moroccan margin. The seismic profiles are between 130 and 260 km in length and between 28 and 13 ocean-bottom seismometers were deployed on each one. One profile was extended on land by 15 landstations in order to better image the zone of continental thinning. A 4.5 km digital streamer and a 7200 cu inch tuned airgun array were used for the acquisition of the seismic data. Additionally magnetic, bathymetric and high resolution seismic data were acquired in the study region. Preliminary results from tomographic inversion of the first arrivals from the ocean-bottom seismometer data image the zone of crustal thinning from about 25 km to 6 km in the basin along about 70 kilometers of the profiles which are located perpendicular to the margin. The oceanic crust can be divided into 2 regions, based on the lower crustal velocities. Upper mantle velocities are about 8.0 km/s. The coincident reflection seismic data show the fine basement and sedimentary structures including salt tectonics in the basin. The comparative study of the two conjugate profiles on the

Volcanic and nonvolcanic rifted margins of the Red Sea and Gulf of Aden: Crustal cooling and margin evolution in Yemen

NASA Astrophysics Data System (ADS)

Menzies, Martin; Gallagher, Kerry; Yelland, Andrew; Hurford, Anthony J.

1997-06-01

New apatite fission track (AFT) data from the southern Red Sea volcanic and the Gulf of Aden nonvolcanic margins provide important constraints on the timing of crustal cooling relative to periods of volcanism and lithosphere extension. The AFT data define several regions of extension immediately adjacent to the Red Sea margin with AFT ages < 25 Ma and track-length distributions consistent with rapid cooling. Elevated Precambrian basement highs on the rift shoulder have AFT ages ≫ 100 Ma and track-length distributions indicative of a complex pre-rift history. An intervening area along the Red Sea and Gulf of Aden margins, and inland along the Balhaf graben (Jurassic rift), has AFT ages of 25-100 Ma. and track-length distributions indicative of rapid cooling. Elevated Precambrian basement highs are juxtaposed against topographically lower extended coastal terranes with sharp contrasts in AFT ages and track-length distributions, pointing to possible reactivation in the Tertiary of lineaments of Precambrian and Jurassic age. Integration of field observations with AFT data and 40Ar/ 39Ar data indicates that, on the Red Sea volcanic margin, surface uplift was initiated immediately prior to volcanism and that cooling was synchronous with widespread extension and an apparent hiatus in voluminous volcanic activity.

Quantifying the Floe Size Distribution in the Marginal Ice Zone from Satellite Imagery for use in Model Development and Validation

NASA Astrophysics Data System (ADS)

Schweiger, A. J.; Stern, H. L.; Stark, M.; Zhang, J.; Hwang, P.; Steele, M.

2013-12-01

Several key processes in the Marginal Ice Zone (MIZ) of the Arctic Ocean are related to the size of the ice floes, whose diameters range from meters to tens of kilometers. The floe size distribution (FSD) influences mechanical properties of the ice and thus its response to winds, currents, and waves, which is likely to modify the air-sea momentum transfer. The FSD also influences the air-sea heat transfer and the response of the MIZ ice cover to the thermal forcing. The FSD also has a significant role in lateral melting. No existing sea-ice/ocean models currently simulate the FSD in the MIZ. Significant uncertainties in FSD-related processes hinder model incorporation of the FSD, and model development must heavily depend on observations of the FSD for parameterization, calibration, and validation. To support the development and implementation of the FSD in the Marginal Ice Zone Modeling and Assimilation System (MIZMAS), we have conducted an analysis of the FSD in the Beaufort and Chukchi seas using three sources of satellite imagery: NASA's Moderate Resolution Imaging Spectroradiometer (MODIS) on the Terra and Aqua satellites, the Canadian Space Agency's synthetic aperture radar (SAR) on RADARSAT, and declassified National Technical Means imagery from the Global Fiducials Library (GFL) of the U.S. Geological Survey. The MODIS visible and short-wave infrared bands have a pixel size of 250 meters, and are only useful in cloud-free regions. The SAR imagery is unaffected by clouds and darkness, and has a pixel size of 50 meters. The GFL visible imagery, with a pixel size of 1 meter, is only useful in cloud-free regions. The resolution and spatial extent of the various image products allows us to identify ice floes of all sizes from 10 meters to 100 kilometers. The general procedure for identifying ice floes in the imagery is as follows: delineate cloud-free regions (if necessary); choose a threshold to separate ice from water, and create a binary image; apply the

Marginal Ice Zone Processes Observed from Unmanned Aerial Systems

NASA Astrophysics Data System (ADS)

Zappa, C. J.

2015-12-01

Recent years have seen extreme changes in the Arctic. Marginal ice zones (MIZ), or areas where the "ice-albedo feedback" driven by solar warming is highest and ice melt is extensive, may provide insights into the extent of these changes. Furthermore, MIZ play a central role in setting the air-sea CO2 balance making them a critical component of the global carbon cycle. Incomplete understanding of how the sea-ice modulates gas fluxes renders it difficult to estimate the carbon budget in MIZ. Here, we investigate the turbulent mechanisms driving mixing and gas exchange in leads, polynyas and in the presence of ice floes using both field and laboratory measurements. Measurements from unmanned aerial systems (UAS) in the marginal ice zone were made during 2 experiments: 1) North of Oliktok Point AK in the Beaufort Sea were made during the Marginal Ice Zone Ocean and Ice Observations and Processes EXperiment (MIZOPEX) in July-August 2013 and 2) Fram Strait and Greenland Sea northwest of Ny-Ålesund, Svalbard, Norway during the Air-Sea-Ice Physics and Biogeochemistry Experiment (ASIPBEX) April - May 2015. We developed a number of new payloads that include: i) hyperspectral imaging spectrometers to measure VNIR (400-1000 nm) and NIR (900-1700 nm) spectral radiance; ii) net longwave and net shortwave radiation for ice-ocean albedo studies; iii) air-sea-ice turbulent fluxes as well as wave height, ice freeboard, and surface roughness with a LIDAR; and iv) drone-deployed micro-drifters (DDµD) deployed from the UAS that telemeter temperature, pressure, and RH as it descends through the atmosphere and temperature and salinity of the upper meter of the ocean once it lands on the ocean's surface. Visible and IR imagery of melting ice floes clearly defines the scale of the ice floes. The IR imagery show distinct cooling of the skin sea surface temperature (SST) as well as an intricate circulation and mixing pattern that depends on the surface current, wind speed, and near

Regrounding in Place: Paths to Native American Truths at the Margins

ERIC Educational Resources Information Center

Lucas, Michael

2013-01-01

Margin acts as ground to receive the figure of the text. Margin is initially unreadable, but as suggested by gestalt studies, may be reversed, or regrounded. A humanities course, "Native American Architecture and Place," was created for a polytechnic student population, looking to place as an inroad for access to the margins of a better…

Texas curve margin of safety.

DOT National Transportation Integrated Search

2013-01-01

This software can be used to assist with the assessment of margin of safety for a horizontal curve. It is intended for use by engineers and technicians responsible for safety analysis or management of rural highway pavement or traffic control devices...

Marginal Bone Loss after Ten Years in an Adult Danish Population: A Radiographic Study.

PubMed

Bahrami, Golnosh; Vaeth, Michael; Wenzel, Ann; Isidor, Flemming

To evaluate marginal bone loss over a 10-year period in individuals and in tooth groups in relation to age and level of marginal bone. In 1997, 616 randomly selected individuals (mean age: 42 years, range: 21-63 years) underwent a full-mouth radiographic survey. In 2008, the survey was repeated in 362 of the same individuals (182 women and 180 men). The marginal bone level of each tooth was measured in mm from the cementoenamel junction to the marginal bone. These measurements were used to calculate marginal bone loss during the 10-year period for individuals and tooth groups in relation to age and to baseline marginal bone level, calculated as the average between measurements in 1997 and 2008 to circumvent regression towards the mean. The average annual marginal bone loss was 0.09 mm (SD ± 0.04 mm) during the 10-year study period. The association between marginal bone loss and baseline marginal bone level was more pronounced in the youngest age group, compared to the other age groups. Molars displayed the most severe bone loss during the study period. Marginal bone loss over a 10-year period is associated with age and baseline marginal bone level. Younger individuals with a reduced marginal bone level were at higher risk for further bone loss. Molars lose marginal bone more rapidly than other tooth groups.

The role of the margins in ice stream dynamics

NASA Technical Reports Server (NTRS)

Echelmeyer, Keith; Harrison, William

1993-01-01

At first glance, it would appear that the bed of the active ice stream plays a much more important role in the overall force balance than do the margins, especially because the ratio of the half-width to depth for a typical ice stream is large (15:1 to 50:1). On the other hand, recent observations indicate that at least part of the ice stream is underlain by a layer of very weak till (shear strength about 2 kPa), and this weak basal layer would then imply that some or all of the resistive drag is transferred to the margins. In order to address this question, a detailed velocity profile near Upstream B Camp, which extends from the center of the ice stream, across the chaotic shear margin, and onto the Unicorn, which is part of the slow-moving ice sheet was measured. Comparison of this observed velocity profile with finite-element models of flow shows several interesting features. First, the shear stress at the margin is on the order of 130 kPa, while the mean value along the bed is about 15 kPa. Integration of these stresses along the boundaries indicates that the margins provide 40 to 50 percent, and the bed, 60 to 40 percent of the total resistive drag needed to balance the gravitational driving stress in this region. (The range of values represents calculations for different values of surface slope.) Second, the mean basal stress predicted by the models shows that the entire bed cannot be blanketed by the weak till observed beneath upstream B - instead there must be a distribution of weak till and 'sticky spots' (e.g., 85 percent till and 15 percent sticky spots of resistive stress equal to 100 kPa). If more of the bed were composed of weak till, then the modeled velocity would not match that observed. Third, the ice must exhibit an increasing enhancement factor as the margins are approached (E equals 10 in the chaotic zone), in keeping with laboratory measurements on ice under prolonged shear strain. Also, there is either a narrow zone of somewhat stiffer ice (E

The role of the margins in ice stream dynamics

NASA Astrophysics Data System (ADS)

Echelmeyer, Keith; Harrison, William

1993-07-01

At first glance, it would appear that the bed of the active ice stream plays a much more important role in the overall force balance than do the margins, especially because the ratio of the half-width to depth for a typical ice stream is large (15:1 to 50:1). On the other hand, recent observations indicate that at least part of the ice stream is underlain by a layer of very weak till (shear strength about 2 kPa), and this weak basal layer would then imply that some or all of the resistive drag is transferred to the margins. In order to address this question, a detailed velocity profile near Upstream B Camp, which extends from the center of the ice stream, across the chaotic shear margin, and onto the Unicorn, which is part of the slow-moving ice sheet was measured. Comparison of this observed velocity profile with finite-element models of flow shows several interesting features. First, the shear stress at the margin is on the order of 130 kPa, while the mean value along the bed is about 15 kPa. Integration of these stresses along the boundaries indicates that the margins provide 40 to 50 percent, and the bed, 60 to 40 percent of the total resistive drag needed to balance the gravitational driving stress in this region. (The range of values represents calculations for different values of surface slope.) Second, the mean basal stress predicted by the models shows that the entire bed cannot be blanketed by the weak till observed beneath upstream B - instead there must be a distribution of weak till and 'sticky spots' (e.g., 85 percent till and 15 percent sticky spots of resistive stress equal to 100 kPa). If more of the bed were composed of weak till, then the modeled velocity would not match that observed. Third, the ice must exhibit an increasing enhancement factor as the margins are approached (E equals 10 in the chaotic zone), in keeping with laboratory measurements on ice under prolonged shear strain. Also, there is either a narrow zone of somewhat stiffer ice (E

Cosmogenic 36Cl in karst waters: Quantifying contributions from atmospheric and bedrock sources

NASA Astrophysics Data System (ADS)

Johnston, V. E.; McDermott, F.

2009-12-01

Improved reconstructions of cosmogenic isotope production through time are crucial to understand past solar variability. As a preliminary step to derive atmospheric 36Cl/Cl solar proxy time-series from speleothems, we quantify 36Cl sources in cave dripwaters. Atmospheric 36Cl fallout rates are a potential proxy for solar output; however extraneous 36Cl derived from in-situ production in cave host-rocks could complicate the solar signal. Results from numerical modeling and preliminary geochemical data presented here show that the atmospheric 36Cl source dominates in many, but not all cave dripwaters. At favorable low elevation, mid-latitude sites, 36Cl based speleothem solar irradiance reconstructions could extend back to 500 ka, with a possible centennial scale temporal resolution. This would represent a marginal improvement in resolution compared with existing polar ice core records, with the added advantages of a wider geographic range, independent U-series constrained chronology, and the potential for contemporaneous climate signals within the same speleothem material.

Quantifying Pilot Contribution to Flight Safety during Drive Shaft Failure

NASA Technical Reports Server (NTRS)

Kramer, Lynda J.; Etherington, Tim; Last, Mary Carolyn; Bailey, Randall E.; Kennedy, Kellie D.

2017-01-01

Accident statistics cite the flight crew as a causal factor in over 60% of large transport aircraft fatal accidents. Yet, a well-trained and well-qualified pilot is acknowledged as the critical center point of aircraft systems safety and an integral safety component of the entire commercial aviation system. The latter statement, while generally accepted, cannot be verified because little or no quantitative data exists on how and how many accidents/incidents are averted by crew actions. A joint NASA/FAA high-fidelity motion-base simulation experiment specifically addressed this void by collecting data to quantify the human (pilot) contribution to safety-of-flight and the methods they use in today's National Airspace System. A human-in-the-loop test was conducted using the FAA's Oklahoma City Flight Simulation Branch Level D-certified B-737-800 simulator to evaluate the pilot's contribution to safety-of-flight during routine air carrier flight operations and in response to aircraft system failures. These data are fundamental to and critical for the design and development of future increasingly autonomous systems that can better support the human in the cockpit. Eighteen U.S. airline crews flew various normal and non-normal procedures over a two-day period and their actions were recorded in response to failures. To quantify the human's contribution to safety of flight, crew complement was used as the experiment independent variable in a between-subjects design. Pilot actions and performance during single pilot and reduced crew operations were measured for comparison against the normal two-crew complement during normal and non-normal situations. This paper details the crew's actions, including decision-making, and responses while dealing with a drive shaft failure - one of 6 non-normal events that were simulated in this experiment.

Engineering analysis division internal note. OFT-1 margin assessment. [results of analysis to determine space shuttle subsystem margins for orbital flight test

NASA Technical Reports Server (NTRS)

Austin, L. D., Jr.

1977-01-01

The results are documented of an analysis conducted to determine space shuttle vehicle (SSV) subsystem margins for the reference flight profile for the first orbital flight test (OFT-1). In general, the results show increased margins for the OFT-1 indicators when compared to Mission 3A resutls. The inclusion of element and wing aerodynamic variations on OFT-1, in combination with winds and systems dispersions, resulted in the forward Z (FTO1) attach load indicator exceeding specified limits. The inboard and outboard elevon hinge moment margins (9 percent and 3 percent, respectively) on OFT-1 reflect values consistent with the load relief requirements dictated by elevon hinge moment variations. All other structural load indicators for OFT-1 had margins in excess of 10 percent. The SSV first stage stagnation heating indicators for OFT-1 were about 45 percent less than for Mission 3A. The hydraulic systems demands for both missions were essentially the same. The results also show OFT-1 performance requirements from the consideration of winds and dispersions to be approximately 3,300 lbs greater than Mission 3A.

Perceived Marginalization and the Prediction of Romantic Relationship Stability

ERIC Educational Resources Information Center

Lehmiller, Justin J.; Agnew, Christopher R.

2007-01-01

The present research examined how perceived marginalization of one's romantic relationship is associated with level of future commitment to and stability of that involvement. Results from a 7-month longitudinal study of romantically involved individuals (N = 215) revealed that perceived social network marginalization at Time 1 predicted breakup…

Marginalization of girl mothers during reintegration from armed groups in Sierra Leone.

PubMed

Burman, M E; McKay, S

2007-12-01

Although the widespread presence of girls who participate in fighting forces is increasingly recognized, they remain a highly marginalized group globally, receiving little attention either during or after armed conflict. This is especially true for "girl mothers," girls who return to communities with children born while members of fighting forces. The concept of marginalization (Hall et al. 1994) is used to examine what happens to girl soldiers, especially girl mothers, in the aftermath of armed conflict when they seek to reintegrate back into their communities. This analysis, as part of a larger study of reintegration of girl mothers, is based on field work with girls who were in fighting forces in northwest Sierra Leone, especially those who returned with children. The type and level of marginalization these girls experience is consistent with the conceptualization of marginalization; however, they lack voice and experience shame and vulnerability. Moreover, economics were fundamentally related to their marginalization. The girls' access to resources was significantly constrained because the area was heavily impacted by the war and because of widespread poverty throughout Sierra Leone. The findings raise important questions about marginalization of girls affected by war. Girls and girl mothers experience an extremely high level of marginalization; however, some aspects are not consistent with the original conceptualization of marginalization. Theory development in nursing needs to incorporate multiple voices, especially those of the very marginalized and be done in such a manner that benefits and empowers.

What makes up marginal lands and how can it be defined and classified?

NASA Astrophysics Data System (ADS)

Ivanina, Vadym

2017-04-01

Definitions of marginal lands are often not explicit. The term "marginal" is not supported by either a precise definition or research to determine which lands fall into this category. To identify marginal lands terminology/methodology is used which varies between physical characteristics and the current land use of a site as basic perspective. The term 'Marginal' is most commonly followed by 'degraded' lands, and other widely used terms such as 'abandoned', 'idle', 'pasture', 'surplus agricultural land', 'Conservation Reserve Programme' (CRP)', 'barren and carbon-poor land', etc. Some terms are used synonymously. To the category of "marginal" lands are predominantly included lands which are excluded from cultivation due to economic infeasibility or physical restriction for growing conventional crops. Such sites may still have potential to be used for alternative agricultural practice, e.g. bioenergy feedstock production. The existing categorizing of marginal lands does not allow evaluating soil fertility potential or to define type and level of constrains for growing crops as the reason of a low practical value with regards to land use planning. A new marginal land classification has to be established and developed. This classification should be built on criteria of soil biophysical properties, ecologic, environment and climate handicaps for growing crops, be easy in use and of high practical value. The SEEMLA consortium made steps to build such a marginal land classification which is based on direct criteria depicting soil properties and constrains, and defining their productivity potential. By this classification marginal lands are divided into eleven categories: shallow rooting, low fertility, stony texture, sandy texture, clay texture, salinic, sodicic, acidic, overwet, eroded, and contaminated. The basis of this classification was taken criteria modified after and adapted from Regulation EU (1305)2013. To define an area of marginal lands with climate and

Marginal Emissions Factors for Electricity Generation in the Midcontinent ISO.

PubMed

Thind, Maninder P S; Wilson, Elizabeth J; Azevedo, Inês L; Marshall, Julian D

2017-12-19

Environmental consequences of electricity generation are often determined using average emission factors. However, as different interventions are incrementally pursued in electricity systems, the resulting marginal change in emissions may differ from what one would predict based on system-average conditions. Here, we estimate average emission factors and marginal emission factors for CO 2 , SO 2 , and NO x from fossil and nonfossil generators in the Midcontinent Independent System Operator (MISO) region during years 2007-2016. We analyze multiple spatial scales (all MISO; each of the 11 MISO states; each utility; each generator) and use MISO data to characterize differences between the two emission factors (average; marginal). We also explore temporal trends in emissions factors by hour, day, month, and year, as well as the differences that arise from including only fossil generators versus total generation. We find, for example, that marginal emission factors are generally higher during late-night and early morning compared to afternoons. Overall, in MISO, average emission factors are generally higher than marginal estimates (typical difference: ∼20%). This means that the true environmental benefit of an energy efficiency program may be ∼20% smaller than anticipated if one were to use average emissions factors. Our analysis can usefully be extended to other regions to support effective near-term technical, policy and investment decisions based on marginal rather than only average emission factors.

Passive margins getting squeezed in the mantle convection vice

NASA Astrophysics Data System (ADS)

Yamato, Philippe; Husson, Laurent; Becker, Thorsten W.; Pedoja, Kevin

2014-05-01

Passive margins often exhibit uplift, exhumation and tectonic inversion. We speculate that the compression in the lithosphere gradually increased during the Cenozoic. In the same time, the many mountain belts at active margins that accompany this event seem readily witness this increase. However, how that compression increase affects passive margins remains unclear. In order to address this issue, we design a 2D viscous numerical model wherein a lithospheric plate rests above a weaker mantle. It is driven by a mantle conveyor belt, alternatively excited by a lateral downwelling on one side, an upwelling on the other side, or both simultaneously. The lateral edges of the plate are either free or fixed, representing the cases of free convergence, and collision or slab anchoring, respectively. This distinction changes the upper boundary condition for mantle circulation and, as a consequence, the stress field. Our results show that between these two regimes, the flow pattern transiently evolves from a free-slip convection mode towards a no-slip boundary condition above the upper mantle. In the second case, the lithosphere is highly stressed horizontally and deforms. For an equivalent bulk driving force, compression increases drastically at passive margins provided that upwellings are active. Conversely, if downwellings alone are activated, compression occurs at short distances from the trench and extension prevails elsewhere. These results are supported by Earth-like 3D spherical models that reveal the same pattern, where active upwellings are required to excite passive margins compression. These results support the idea that compression at passive margins, is the response to the underlying mantle flow, that is increasingly resisted by the Cenozoic collisions.

Computer-aided marginal artery detection on computed tomographic colonography

NASA Astrophysics Data System (ADS)

Wei, Zhuoshi; Yao, Jianhua; Wang, Shijun; Liu, Jiamin; Summers, Ronald M.

2012-03-01

Computed tomographic colonography (CTC) is a minimally invasive technique for colonic polyps and cancer screening. The marginal artery of the colon, also known as the marginal artery of Drummond, is the blood vessel that connects the inferior mesenteric artery with the superior mesenteric artery. The marginal artery runs parallel to the colon for its entire length, providing the blood supply to the colon. Detecting the marginal artery may benefit computer-aided detection (CAD) of colonic polyp. It can be used to identify teniae coli based on their anatomic spatial relationship. It can also serve as an alternative marker for colon localization, in case of colon collapse and inability to directly compute the endoluminal centerline. This paper proposes an automatic method for marginal artery detection on CTC. To the best of our knowledge, this is the first work presented for this purpose. Our method includes two stages. The first stage extracts the blood vessels in the abdominal region. The eigenvalue of Hessian matrix is used to detect line-like structures in the images. The second stage is to reduce the false positives in the first step. We used two different masks to exclude the false positive vessel regions. One is a dilated colon mask which is obtained by colon segmentation. The other is an eroded visceral fat mask which is obtained by fat segmentation in the abdominal region. We tested our method on a CTC dataset with 6 cases. Using ratio-of-overlap with manual labeling of the marginal artery as the standard-of-reference, our method yielded true positive, false positive and false negative fractions of 89%, 33%, 11%, respectively.

Layer 6 cortical neurons require Reelin-Dab1 signaling for cellular orientation, Golgi deployment, and directed neurite growth into the marginal zone.

PubMed

O'Dell, Ryan S; Ustine, Candida J M; Cameron, David A; Lawless, Sean M; Williams, Rebecca M; Zipfel, Warren R; Olson, Eric C

2012-07-07

The secreted ligand Reelin is believed to regulate the translocation of prospective layer 6 (L6) neocortical neurons into the preplate, a loose layer of pioneer neurons that overlies the ventricular zone. Recent studies have also suggested that Reelin controls neuronal orientation and polarized dendritic growth during this period of early cortical development. To explicitly characterize and quantify how Reelin controls this critical aspect of neurite initiation and growth we used a new ex utero explant model of early cortical development to selectively label a subset of L6 cortical neurons for complete 3-D reconstruction. The total neurite arbor sizes of neurons in Reelin-deficient (reeler mutant) and Dab1-deficient (Reelin-non-responsive scrambler mutant) cortices were quantified and unexpectedly were not different than control arbor lengths (p = 0.51). For each mutant, however, arbor organization was markedly different: mutant neurons manifested more primary processes (neurites emitted directly from the soma) than wild type, and these neurites were longer and displayed less branching. Reeler and scrambler mutant neurites extended tangentially rather than radially, and the Golgi apparatus that normally invests the apical neurite was compact in both reeler and scrambler mutants. Mutant cortices also exhibited a neurite "exclusion zone" which was relatively devoid of L6 neuron neurites and extended at least 15 μm beneath the pial surface, an area corresponding to the marginal zone (MZ) in the wild type explants. The presence of an exclusion zone was also indicated in the orientation of mutant primary neurite and neuronal somata, which failed to adopt angles within ~20˚ of the radial line to the pial surface. Injection of recombinant Reelin to reeler, but not scrambler, mutant cortices fully rescued soma orientation, Golgi organization, and dendritic projection defects within four hrs. These findings indicate Reelin promotes directional dendritic growth into

Hydraulic safety margins and air-seeding thresholds in roots, trunks, branches and petioles of four northern hardwood trees.

PubMed

Wason, Jay W; Anstreicher, Katherine S; Stephansky, Nathan; Huggett, Brett A; Brodersen, Craig R

2018-04-16

During drought, xylem sap pressures can approach or exceed critical thresholds where gas embolisms form and propagate through the xylem network, leading to systemic hydraulic dysfunction. The vulnerability segmentation hypothesis (VSH) predicts that low-investment organs (e.g. leaf petioles) should be more vulnerable to embolism spread compared to high-investment, perennial organs (e.g. trunks, stems), as a means of mitigating embolism spread and excessive negative pressures in the perennial organs. We tested this hypothesis by measuring air-seeding thresholds using the single-vessel air-injection method and calculating hydraulic safety margins in four northern hardwood tree species of the northeastern United States, in both saplings and canopy height trees, and at five points along the soil-plant-atmosphere continuum. Acer rubrum was the most resistant to air-seeding and generally supported the VSH. However, Fagus grandifolia, Fraxinus americana and Quercus rubra showed little to no variation in air-seeding thresholds across organ types within each species. Leaf-petiole xylem operated at water potentials close to or exceeding their hydraulic safety margins in all species, whereas roots, trunks and stems of A. rubrum, F. grandifolia and Q. rubra operated within their safety margins, even during the third-driest summer in the last 100 yr. © 2018 The Authors. New Phytologist © 2018 New Phytologist Trust.

Marginalized Student Access to Technology Education

NASA Astrophysics Data System (ADS)

Kurtcu, Wanda M.

The purpose of this paper is to investigate how a teacher can disrupt an established curriculum that continues the cycle of inequity of access to science, technology, engineering, and math (STEM) curriculum by students in alternative education. For this paper, I will focus on the technology components of the STEM curriculum. Technology in the United States, if not the world economy, is developing at a rapid pace. Many areas of day to day living, from applying for a job to checking one's bank account online, involve a component of science and technology. The 'gap' in technology education is emphasized between the 'haves and have-nots', which is delineated along socio-economic lines. Marginalized students in alternative education programs use this equipment for little else than remedial programs and credit recovery. This level of inequity further widens in alternative education programs and affects the achievement of marginalized students in credit recovery or alternative education classes instead of participation technology classes. For the purposes of this paper I focus on how can I decrease the inequity of student access to 21st century technology education in an alternative education program by addressing the established curriculum of the program and modifying structural barriers of marginalized student access to a technology focused curriculum.

The Marginal Costs of Instruction.

ERIC Educational Resources Information Center

Hoenack, Stephen A.; And Others

1986-01-01

A study of instructional costs in a large university focuses on graduate education, draws inferences about the economic costs of incremental or marginal enrollments, and examines how the costs facing faculty differ from those incurred by the administration and the state legislature. (MSE)

Deep continental margin reflectors

USGS Publications Warehouse

Ewing, J.; Heirtzler, J.; Purdy, M.; Klitgord, Kim D.

1985-01-01

In contrast to the rarity of such observations a decade ago, seismic reflecting and refracting horizons are now being observed to Moho depths under continental shelves in a number of places. These observations provide knowledge of the entire crustal thickness from the shoreline to the oceanic crust on passive margins and supplement Consortium for Continental Reflection Profiling (COCORP)-type measurements on land.

Perforated marginal ulcers after laparoscopic gastric bypass.

PubMed

Felix, Edward L; Kettelle, John; Mobley, Elijah; Swartz, Daniel

2008-10-01

Perforated marginal ulcer (PMU) after laparoscopic Roux-en-Y gastric bypass (LRYGB) is a serious complication, but its incidence and etiology have rarely been investigated. Therefore, a retrospective review of all patients undergoing LRYGB at the authors' center was conducted to determine the incidence of PMU and whether any causative factors were present. A prospectively kept database of all patients at the authors' bariatric center was retrospectively reviewed. The complete records of patients with a PMU were examined individually for accuracy and analyzed for treatment, outcome, and possible underlying causes of the marginal perforation. Between April 1999 and August 2007, 1% of the patients (35/3,430) undergoing laparoscopic gastric bypass experienced one or more perforated marginal ulcers 3 to 70 months (median, 18 months) after LRYGB. The patients with and without perforation were not significantly different in terms of mean age (37 vs 41 years), weight (286 vs 287 lb), body mass index (BMI) (46 vs 47), or female gender (89% vs 83%). Of the patients with perforations, 2 (6%) were taking steroids, 10 (29%) were receiving nonsteroidal antiinflammatory drugs (NSAIDs) at the time of the perforation, 18 (51%) were actively smoking, and 6 of the smokers also were taking NSAIDs. Eleven of the patients (31%) who perforated did not have at least one of these possible risk factors, but 4 (36%) of the 11 patients in this group had been treated after bypass for a marginal ulcer. Only 7 (20%) of the 35 patients who had laparoscopic bypass, or 7 (0.2%) in the entire group of 3,430 patients, perforated without any warning. There were no deaths, but three patients reperforated. The incidence of a marginal ulcer perforating after LRYGB was significant (>1%) and appeared to be related to smoking or the use of NSAIDs or steroids. Because only 0.2% of all patients acutely perforated without some risk factor or warning, long-term ulcer prophylaxis or treatment may be necessary

The South China sea margins: Implications for rifting contrasts

USGS Publications Warehouse

Hayes, D.E.; Nissen, S.S.

2005-01-01

Implications regarding spatially complex continental rifting, crustal extension, and the subsequent evolution to seafloor spreading are re-examined for the northern and southern-rifted margins of the South China Sea. Previous seismic studies have shown dramatic differences in the present-day crustal thicknesses as the manifestations of the strain experienced during the rifting of the margin of south China. Although the total crustal extension is presumed to be the same along the margin and adjacent ocean basin, the amount of continental crustal extension that occurred is much less along the east and central segments of the margin than along the western segment. This difference was accommodated by the early formation of oceanic crust (creating the present-day South China Sea basin) adjacent to the eastern margin segment while continued extension of continental crust was sustained to the west. Using the observed cross-sectional areas of extended continental crust derived from deep penetration seismics, two end-member models of varying rift zone widths and varying initial crustal thicknesses are qualitatively examined for three transects. Each model implies a time difference in the initiation of seafloor spreading inferred for different segments along the margin. The two models examined predict that the oceanic crust of the South China Sea basin toward the west did not begin forming until sometime between 6-12 my after its initial formation (???32 Ma) toward the east. These results are compatible with crustal age interpretations of marine magnetic anomalies. Assuming rifting symmetry with conjugate margin segments now residing along the southern portions of the South China Sea basin implies that the total width of the zone of rifting in the west was greater than in the east by about a factor of two. We suggest the most likely causes of the rifting differences were east-west variations in the rheology of the pre-rift crust and associated east-west variations in the

Early graft dysfunction and mortality rate in marginal donor liver transplantation.

PubMed

Sarkut, Pmar; Gülcü, Bariş; Işçimen, Remzi; Kiyici, Murat; Türker, Gürkan; Topal, Naile Bolca; Ozen, Yilmaz; Kaya, Ekrem

2014-01-01

To determine the effect of marginal donor livers on mortality and graft survival in liver transplantation (LT) recipients. Donors with any 1 of following were considered marginal donors: age ≥65 years, sodium level ≥ 165 mmol/L and cold ischemia time ≥ 12 h. Donors were classified according to the donor risk index (DRI) < 1.7 and ≥ 1.7. The transplant recipients' model for end-stage liver disease (MELD) scores were considered low if < 20 and high if ≥ 20. Early graft dysfunction (EGD) and mortality rate were evaluated. During the study period 47 patients underwent cadaveric LT. The mean age of the donors and recipients was 45 years (range: 5-72 years) and 46 years (range: 4-66 years), respectively. In all, there were 15 marginal donors and 18 donors with a DRI > 1.7. In total, 4 LT patients that received livers from marginal donors and 5 that received livers from donors with a DRI ≥ 1.7 had EGD. Among the recipients of marginal livers, 5 died, versus 4 of the recipients of standard livers. There was no significant difference in EGD or mortality rate between the patients that received livers from marginal donors or those with a DRI ≥ 1.7 and patients that received standard donor livers. Marginal and DRI ≥ 1.7 donors negatively affected LT outcomes, but not significantly.

Permian-Triassic Tethyan realm reorganization: Implications for the outward Pangea margin

NASA Astrophysics Data System (ADS)

Riel, Nicolas; Jaillard, Etienne; Martelat, Jean-Emmanuel; Guillot, Stéphane; Braun, Jean

2018-01-01

We present a new conceptual model to explain the first order Permian-Triassic evolution of the whole > 30 000 km long Pangea margin facing the Panthalassa ocean. Compilation of available geological, geochemical, geochronogical and paleomagnetic data all along this system allowed us to distinguish three part of the margin: western Laurentia, western Gondwana and eastern Gondwana. These segments record distinct tectonic and magmatic events, which all occur synchronously along the whole margin and correlate well with the main geodynamic events of this period, i.e. subduction of the Paleotethys mid-ocean ridge at 310-280 Ma, opening of the Neotethys at 280-260 Ma, counterclockwise rotation of Pangea at 260-230 Ma and closure of the Paleotethys at 230-220 Ma. Between 260 and 230 Ma, the reorganization of the Tethyan realm triggered the up to 35° rotation of Pangea around an Euler pole located in northernmost South America. This implied both an increase and a decrease of the convergence rate between the margin and the Panthalassa ocean, north and south of the Euler pole, respectively. Thus, the Permian-Triassic Pangean margin was marked: in western Laurentia by marginal sea closure, in western Gondwana by widespread bimodal magmatic and volcanic activity, in eastern Gondwana by transpressive orogenic phase. Therefore, we propose that the Permian-Triassic evolution of the outward margin of Pangea was controlled by the Tethyan realm reorganization.

The origin of Karaj dam basement sill marginal reversal by Soret fractionation

NASA Astrophysics Data System (ADS)

Maghdour-Mashhour, Reza; Esmaeily, Dariush

2010-05-01

The Karaj dam basement sill (KDBS), located North West of Tehran, northern Iran, is one of the several E-W-trending plutons in the Albourz Mountains. The KDBS consists of a layered series between upper and lower chilled margins. The rocks of the chilled margins are gabbroic in composition and porphyritic, with euhedral to subhedral plagioclase and clinopyroxene megacrysts up to 5 mm long. The rocks become coarse-grained toward the center of the sill and show a gradual transition from porphyritic to equigranular texture. Field and petrographic observations reveal a reverse trend in marginal units crystallization from the eutectic point to the main magma composition; i.e., the olivine-bearing gabbro (porphyritic chilled margin), which has a eutectic composition, crystallized prior to the marginal gabbros, which have a cotectic or near-cotectic composition, as plagioclase laths in the gabbroic unit are embedded in large crystals of clinopyroxene and this phenomenon is believed to result from the cotectic crystallization of plagioclase and clinopyroxene. Four major mechanisms are proposed and discussed in order to find the exact mechanism responsible for marginal reversal formation as following: 1) Crystal settling is a gravity-dependent mechanism and phenocrysts must have settled to form a layer at the bottom of the sill, showing sharp upper boundary which is not observable in KDBS. Besides, the reverse fractionation of inwardly-dipping sequence of mentioned sill occurs in layers with primary dips up to 55°. Consequently capability of marginal reversals to develop along steeply inclined chamber margins, by this mechanism is implausible. 2) Multiple injections of successive magma pulses fails to explain the origin of marginal reversal since the transition along the entire length of marginal reversal is gradual also there is no compositional break or chilled contact between two mentioned units of KDBS margin (Olivine-gabbro and marginal gabbro). 3) The idea of

Time-Domain Stability Margin Assessment

NASA Technical Reports Server (NTRS)

Clements, Keith

2016-01-01

The baseline stability margins for NASA's Space Launch System (SLS) launch vehicle were generated via the classical approach of linearizing the system equations of motion and determining the gain and phase margins from the resulting frequency domain model. To improve the fidelity of the classical methods, the linear frequency domain approach can be extended by replacing static, memoryless nonlinearities with describing functions. This technique, however, does not address the time varying nature of the dynamics of a launch vehicle in flight. An alternative technique for the evaluation of the stability of the nonlinear launch vehicle dynamics along its trajectory is to incrementally adjust the gain and/or time delay in the time domain simulation until the system exhibits unstable behavior. This technique has the added benefit of providing a direct comparison between the time domain and frequency domain tools in support of simulation validation.

Dynamic trapping near a quantum critical point

NASA Astrophysics Data System (ADS)

Kolodrubetz, Michael; Katz, Emanuel; Polkovnikov, Anatoli

2015-02-01

The study of dynamics in closed quantum systems has been revitalized by the emergence of experimental systems that are well-isolated from their environment. In this paper, we consider the closed-system dynamics of an archetypal model: spins driven across a second-order quantum critical point, which are traditionally described by the Kibble-Zurek mechanism. Imbuing the driving field with Newtonian dynamics, we find that the full closed system exhibits a robust new phenomenon—dynamic critical trapping—in which the system is self-trapped near the critical point due to efficient absorption of field kinetic energy by heating the quantum spins. We quantify limits in which this phenomenon can be observed and generalize these results by developing a Kibble-Zurek scaling theory that incorporates the dynamic field. Our findings can potentially be interesting in the context of early universe physics, where the role of the driving field is played by the inflaton or a modulus field.

Numerical experiments of volcanic dominated rifts and passive margins

NASA Astrophysics Data System (ADS)

Korchinski, Megan; Teyssier, Christian; Rey, Patrice; Whitney, Donna; Mondy, Luke

2017-04-01

Continental rifting is driven by plate tectonic forces (passive rifting), thermal thinning of the lithosphere over a hotspot (active rifting), or a combination of the two. Successful rifts develop into passive margins where pre-drift stretching is accompanied by normal faulting, clastic sedimentation, and various degrees of magmatism. The structure of volcanic passive margins (VPM) differs substantially from margins that are dominated by sedimentation. VPMs are typically narrow, with a lower continental crust that is intruded by magma and can flow as a low-viscosity layer. To investigate the role of the deep crust in the early development of VPMs, we have developed a suite of 2D thermomechanical numerical experiments (Underworld code) in which the density and viscosity of the deep crust and the density of the rift basin fill are systematically varied. Our experiments show that, for a given rifting velocity, the viscosity of the deep crust and the density of the rift basin fill exert primary controls on early VPM development. The viscosity of the deep crust controls the degree to which the shallow crust undergoes localised faulting or distributed thinning. A weak deep crust localises rifting and is efficiently exhumed to the near-surface, whereas a strong deep crust distributes shallow crust extension and remains buried. A high density rift basin fill results in gravitational loading and increased subsidence rate in cases in which the viscosity of the deep crust is sufficiently low to allow that layer to be displaced by the sinking basin fill. At the limit, a low viscosity deep crust overlain by a thick basalt-dominated fill generates a gravitational instability, with a drip of cool basalt that sinks and ponds at the Moho. Experiment results indicate that the deep crust plays a critical role in the dynamic development of volcanic dominated rifts and passive margins. During rifting, the deep continental crust is heated and readily responds to solicitations of the

Experimental validation of the van Herk margin formula for lung radiation therapy

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ecclestone, Gillian; Heath, Emily; Bissonnette, Jean-Pierre

2013-11-15

Purpose: To validate the van Herk margin formula for lung radiation therapy using realistic dose calculation algorithms and respiratory motion modeling. The robustness of the margin formula against variations in lesion size, peak-to-peak motion amplitude, tissue density, treatment technique, and plan conformity was assessed, along with the margin formula assumption of a homogeneous dose distribution with perfect plan conformity.Methods: 3DCRT and IMRT lung treatment plans were generated within the ORBIT treatment planning platform (RaySearch Laboratories, Sweden) on 4DCT datasets of virtual phantoms. Random and systematic respiratory motion induced errors were simulated using deformable registration and dose accumulation tools available withinmore » ORBIT for simulated cases of varying lesion sizes, peak-to-peak motion amplitudes, tissue densities, and plan conformities. A detailed comparison between the margin formula dose profile model, the planned dose profiles, and penumbra widths was also conducted to test the assumptions of the margin formula. Finally, a correction to account for imperfect plan conformity was tested as well as a novel application of the margin formula that accounts for the patient-specific motion trajectory.Results: The van Herk margin formula ensured full clinical target volume coverage for all 3DCRT and IMRT plans of all conformities with the exception of small lesions in soft tissue. No dosimetric trends with respect to plan technique or lesion size were observed for the systematic and random error simulations. However, accumulated plans showed that plan conformity decreased with increasing tumor motion amplitude. When comparing dose profiles assumed in the margin formula model to the treatment plans, discrepancies in the low dose regions were observed for the random and systematic error simulations. However, the margin formula respected, in all experiments, the 95% dose coverage required for planning target volume (PTV) margin

Racialized Spaces in Teacher Discourse: A Critical Discourse Analysis of Place-Based Identities in Roche Bois, Mauritius

ERIC Educational Resources Information Center

Wiehe, Elsa M.

2013-01-01

This eleven-month ethnographic study puts critical discourse analysis in dialogue with postmodern conceptualizations of space and place to explore how eight educators talk about space and in the process, produce racialized spaces in Roche Bois, Mauritius. The macro-historical context of racialization of this urban marginalized community informs…

Can pro-marriage policies work? An analysis of marginal marriages.

PubMed

Frimmel, Wolfgang; Halla, Martin; Winter-Ebmer, Rudolf

2014-08-01

Policies to promote marriage are controversial, and it is unclear whether they are successful. To analyze such policies, one must distinguish between a marriage that is created by a marriage-promoting policy (marginal marriage) and a marriage that would have been formed even in the absence of a state intervention (average marriage). We exploit the suspension of a cash-on-hand marriage subsidy in Austria to examine the differential behavior of marginal and average marriages. The announcement of an impending suspension of this subsidy led to an enormous marriage boom among eligible couples that allows us to locate marginal marriages. Applying a difference-in-differences approach, we show that marginal marriages are surprisingly as stable as average marriages but produce fewer children, children later in marriage, and children who are less healthy at birth.

Marginal Teachers from the Eyes of School Principals: Concept, Problems and Management Strategies

ERIC Educational Resources Information Center

Erdogan, Cetin; Demirkasimoglu, Nihan

2016-01-01

This research aimed to determine how Turkish principals define marginal teachers and which strategies they use to deal with them. Within this purpose, the following points are examined: (a) the concept of marginal teacher, (b) the underlying reasons for marginal teacher behaviors, (c) the problems marginal teachers cause in school settings, (d)…

Positive surgical margins after robotic assisted radical prostatectomy: a multi-institutional study.

PubMed

Patel, Vipul R; Coelho, Rafael F; Rocco, Bernardo; Orvieto, Marcelo; Sivaraman, Ananthakrishnan; Palmer, Kenneth J; Kameh, Darien; Santoro, Luigi; Coughlin, Geoff D; Liss, Michael; Jeong, Wooju; Malcolm, John; Stern, Joshua M; Sharma, Saurabh; Zorn, Kevin C; Shikanov, Sergey; Shalhav, Arieh L; Zagaja, Gregory P; Ahlering, Thomas E; Rha, Koon H; Albala, David M; Fabrizio, Michael D; Lee, David I; Chauhan, Sanket

2011-08-01

Positive surgical margins are an independent predictive factor for biochemical recurrence after radical prostatectomy. We analyzed the incidence of and associative factors for positive surgical margins in a multi-institutional series of 8,418 robotic assisted radical prostatectomies. We analyzed the records of 8,418 patients who underwent robotic assisted radical prostatectomy at 7 institutions. Of the patients 323 had missing data on margin status. Positive surgical margins were categorized into 4 groups, including apex, bladder neck, posterolateral and multifocal. The records of 6,169 patients were available for multivariate analysis. The variables entered into the logistic regression models were age, body mass index, preoperative prostate specific antigen, biopsy Gleason score, prostate weight and pathological stage. A second model was built to identify predictive factors for positive surgical margins in the subset of patients with organ confined disease (pT2). The overall positive surgical margin rate was 15.7% (1,272 of 8,095 patients). The positive surgical margin rate for pT2 and pT3 disease was 9.45% and 37.2%, respectively. On multivariate analysis pathological stage (pT2 vs pT3 OR 4.588, p<0.001) and preoperative prostate specific antigen (4 or less vs greater than 10 ng/ml OR 2.918, p<0.001) were the most important independent predictive factors for positive surgical margins after robotic assisted radical prostatectomy. Increasing prostate weight was associated with a lower risk of positive surgical margins after robotic assisted radical prostatectomy (OR 0.984, p<0.001) and a higher body mass index was associated with a higher risk of positive surgical margins (OR 1.032, p<0.001). For organ confined disease preoperative prostate specific antigen was the most important factor that independently correlated with positive surgical margins (4 or less vs greater than 10 ng/ml OR 3.8, p<0.001). The prostatic apex followed by a posterolateral site was the most

Combination of hand-held probe and microscopy for fluorescence guided surgery in the brain tumor marginal zone.

PubMed

Richter, Johan C O; Haj-Hosseini, Neda; Hallbeck, Martin; Wårdell, Karin

2017-06-01

Visualization of the tumor is crucial for differentiating malignant tissue from healthy brain during surgery, especially in the tumor marginal zone. The aim of the study was to introduce a fluorescence spectroscopy-based hand-held probe (HHF-probe) for tumor identification in combination with the fluorescence guided resection surgical microscope (FGR-microscope), and evaluate them in terms of diagnostic performance and practical aspects of fluorescence detection. Eighteen operations were performed on 16 patients with suspected high-grade glioma. The HHF-probe and the FGR-microscope were used for detection of protoporphyrin (PpIX) fluorescence induced by 5-aminolevulinic acid (5-ALA) and evaluated against histopathological analysis and visual grading done through the FGR-microscope by the surgeon. A ratio of PpIX fluorescence intensity to the autofluorescence intensity (fluorescence ratio) was used to quantify the spectra detected by the probe. Fluorescence ratio medians (range 0 - 40) measured by the probe were related to the intensity of the fluorescence in the FGR-microscope, categorized as "none" (0.3, n=131), "weak" (1.6, n=34) and "strong" (5.4, n=28). Of 131 "none" points in the FGR-microscope, 88 (67%) exhibited fluorescence with the HHF-probe. For the tumor marginal zone, the area under the receiver operator characteristics (ROC) curve was 0.49 for the FGR-microscope and 0.65 for the HHF-probe. The probe was integrated in the established routine of tumor resection using the FGR-microscope. The HHF-probe was superior to the FGR-microscope in sensitivity; it detected tumor remnants after debulking under the FGR-microscope. The combination of the HHF-probe and the FGR-microscope was beneficial especially in the tumor marginal zone. Copyright © 2017 The Authors. Published by Elsevier B.V. All rights reserved.

Making the Invisible Visible: Advancing Quantitative Methods in Higher Education Using Critical Race Theory and Intersectionality

ERIC Educational Resources Information Center

López, Nancy; Erwin, Christopher; Binder, Melissa; Chavez, Mario Javier

2018-01-01

We appeal to critical race theory and intersectionality to examine achievement gaps at a large public university in the American southwest from 2000 to 2015. Using white, high-income women as our reference group, we report linear combinations of marginal effects for six-year graduation rates and developmental course taking across 20 distinct…

Stratigraphy of two conjugate margins (Gulf of Lion and West Sardinia): modeling of vertical movements and sediment budgets

NASA Astrophysics Data System (ADS)

Leroux, Estelle; Gorini, Christian; Aslanian, Daniel; Rabineau, Marina; Blanpied, Christian; Rubino, Jean-Loup; Robin, Cécile; Granjeon, Didier; Taillepierre, Rachel

2016-04-01

The post-rift (~20-0 Ma) vertical movements of the Provence Basin (West Mediterranean) are quantified on its both conjugate (the Gulf of Lion and the West Sardinia) margins. This work is based on the stratigraphic study of sedimentary markers using a large 3D grid of seismic data, correlations with existing drillings and refraction data. The post-rift subsidence is measured by the direct use of sedimentary geometries analysed in 3D [Gorini et al., 2015; Rabineau et al., 2014] and validated by numerical stratigraphic modelling. Three domains were found: on the platform (1) and slope (2), the subsidence takes the form of a seaward tilting with different amplitudes, whereas the deep basin (3) subsides purely vertically [Leroux et al., 2015a]. These domains correspond to the deeper crustal domains respectively highlighted by wide angle seismic data. The continental crust (1) and the thinned continental crust (2) are tilted, whereas the intermediate crust, identified as lower continental exhumed crust [Moulin et al., 2015, Afhilado et al., 2015] (3) sagged. The post-break-up subsidence re-uses the initial hinge lines of the rifting phase. This striking correlation between surface geologic processes and deep earth dynamic processes emphasizes that the sedimentary record and sedimentary markers is a window into deep geodynamic processes and dynamic topography. Pliocene-Pleistocene seismic markers enabled high resolution quantification of sediment budgets over the past 6 Myr [Leroux et al., in press]. Sediment budget history is here completed on the Miocene interval. Thus, the controlling factors (climate, tectonics and eustasy) are discussed. Afilhado, A., Moulin, M., Aslanian, D., Schnürle, P., Klingelhoefer, F., Nouzé, H., Rabineau, M., Leroux, E. & Beslier, M.-O. (2015). Deep crustal structure across a young 1 passive margin from wide-angle and reflection seismic data (The SARDINIA Experiment) - II. Sardinia's margin. Bull. Soc. géol. France, 186, ILP Spec. issue, 4

Modelling of sea floor spreading initiation and rifted continental margin formation

NASA Astrophysics Data System (ADS)

Tymms, V. J.; Isimm Team

2003-04-01

Recent observations of depth dependent (heterogeneous) stretching where upper crustal extension is much less than that of the lower crust and lithospheric mantle at both non-volcanic and volcanic margins plus the discovery of broad domains of exhumed continental mantle at non-volcanic rifted margins are not predicted by existing quantitative models of rifted margin formation which are usually based on intra-continental rift models subjected to very large stretching factors. New conceptual and quantitative models of rifted margin formation are required. Observations and continuum mechanics suggest that the dominant process responsible for rifted continental margin formation is sea-floor spreading of the young ocean ridge, rather than pre-breakup intra-continental rifting. Simple fluid flow models of ocean ridge processes using analytical iso-viscous corner-flow demonstrate that the divergent motion of the upwelling mantle beneath the ocean ridge, when viewed in the reference frame of the young continental margin, shows oceanward flow of the lower continental crust and lithospheric mantle of the young rifted margin giving rise to depth dependent stretching as observed. Single-phase fluid-models have been developed to model the initiation of sea-floor spreading and the thermal, stretching and thinning evolution of the young rifted continental margin. Finite element fluid-flow modelling incorporating the evolving temperature dependent viscosity field on the fluid flow also show depth dependent stretching of the young continental margin. Two-phase flow models of ocean ridges incorporating the transport of both solid matrix and melt fluid (Spiegelman &Reynolds 1999) predict the divergent motion of the asthenosphere and lithosphere matrix, and the focusing of basaltic melt into the narrow axial zone spreading centre at ocean ridges. We are adapting two-phase flow models for application to the initiation of sea-floor spreading and rifted continental margin formation. i

Influence of abutment screw preload on stress distribution in marginal bone.

PubMed

Khraisat, Ameen

2012-01-01

Changes in an implant assembly after abutment connection might possibly cause deformation in the implant/abutment joint and even in the marginal bone. The aim of this study was to evaluate the influence of abutment screw preload through the implant collar on marginal bone stress without external load application. Models of three implant parts made of titanium (implant, abutment, and abutment screw) and cortical bone were built and positioned with computer-aided design software. Meshing and generation of boundary conditions, loads, and interactions were performed. Each part was meshed independently. The sole load applied to the model was a torque of 32 Ncm on the abutment screw about its axis of rotation. The implant collar was deformed axially after the screw was tightened (3 μm). This deformation resulted in 60 MPa of stress in the marginal bone. Moreover, pressure on the marginal bone in a radial direction was observed. It can be concluded that, without any external load application, abutment screw preload exerts stresses on the implant collar and the marginal bone. These findings should help guide the development of new implant/abutment joint designs that exert less stress on the marginal bone.

CO2 laser versus cold steel margin analysis following endoscopic excision of glottic cancer

PubMed Central

2014-01-01

Objective To compare the suitability of CO2 laser with steel instruments for margin excision in transoral laser microsurgery. Methods Prospective randomized blinded study. Patients with glottic cancer undergoing laser resection were randomized to margin excision by either steel instruments or CO2 laser. Margins were analyzed for size, interpretability and degree of artifact by a pathologist who was blinded to technique. Results 45 patients were enrolled in the study with 226 total margins taken. 39 margins taken by laser had marked artifact and 0 were uninterpretable. 20 margins taken by steel instruments had marked artifact, and 2 were uninterpretable. Controlling for margin size, the laser technique was associated with increasing degrees of margin artifact (p = 0.210), but there was no difference in crude rates of uninterpretability (p = 0.24). Conclusion Laser margin excision is associated with a greater degree of artifact than steel instrument excision, but was not associated with higher rate of uninterpretability. PMID:24502856

A Longitudinal View of the Relationship Between Social Marginalization and Obesity

NASA Astrophysics Data System (ADS)

Apolloni, Andrea; Marathe, Achla; Pan, Zhengzheng

We use 3 Waves of the Add Health data collected between 1994 and 2002 to conduct a longitudinal study of the relationship between social marginalization and the weight status of adolescents and young adults. Past studies have shown that overweight and obese children are socially marginalized. This research tests (1) if this is true when we account for the sample size of each group, (2) does this phenomenon hold over time and (3) is it obesity or social marginalization that precedes in time. Our results show that when the sample size for each group is considered, the share of friendship is conforming to the size of the group. This conformity seems to increase over time as the population becomes more obese. Finally, we find that obesity precedes social marginalization which lends credence to the notion that obesity causes social marginalization and not vice versa.

Critical Race Theory in India: "Theory Translation" and the Analysis of Social Identities and Discrimination in Indian Schooling

ERIC Educational Resources Information Center

Goodnight, Melissa Rae

2017-01-01

This article examines ethical and philosophical considerations in "theory translation," i.e. translating a theoretical framework from its original place to another national context. Critical race theory (CRT) was developed in the United States through significant struggle in order to analyze everyday racism. Marginalized groups have…

Role of specimen US for predicting resection margin status in breast conserving therapy.

PubMed

Moschetta, M; Telegrafo, M; Introna, T; Coi, L; Rella, L; Ranieri, V; Cirili, A; Stabile Ianora, A A; Angelelli, G

2015-01-01

To assess the diagnostic accuracy of specimen ultrasound (US) for predicting resection margin status in women undergoing breast conserving therapy for US-detected cancer, having the histological findings as the reference standard. A total of 132 consecutive patients (age range, 34-87 years; mean, 51 years) underwent breast-conserving surgery for US-detected invasive breast cancer. All surgical specimens underwent US examination. The presence of lesion within the specimen and its distance from the specimen margins were assessed considering a threshold distance between the lesion and specimen margins of 10 mm. US findings were then compared with the pathological ones and specimen US. Sensitivity, specificity, diagnostic accuracy, positive (PPV) and negative predictive values (NPV) for predicting histological margin status were evaluated, having the histological findings as the reference standard. The histological examination detected invasive ductal carcinoma in 96/132 (73%) cases, invasive lobular carcinoma in 32/132 (24%), mucinous carcinoma in 4/132 (3%). The pathological margin analysis revealed 96/132 (73%) negative margins and 36 (27%) close/positive margins. US examination detected all 132 breast lesions within the surgical specimens. 110 (83%) negative margins and 22 (17%) positive margins were found on US. Sensitivity, specificity, diagnostic accuracy, PPV and NPV of 44%, 94%, 80%, 73% and 82%, respectively, were found for specimen US. Specimen US represents a time and cost saving imaging tool for evaluating the presence of US detected-breast lesion within surgical specimen and for predicting the histological margin status.

Whipple Resection: Concordance Between Frozen Section And Permanent Section Diagnosis Of Surgical Margins.

PubMed

Bilal, Muhammad; Tariq, Hina; Mamoon, Nadira

2018-01-01

Margin assessment is done in Whipple procedures which are usually performed to resect tumours of head of pancreas and ampullary/periampullary region. Aims and objective of the study are to determine the concordance between frozen sections (FS) and permanent sections (PS) of surgical margins in Whipple resections. It is a retrospective study, from January 2008 to January 2015 (07 years). It includes the specimen with malignancy in final report and for which FS of pancreatic and/or CBD margin(s) were requested. Data was retrieved from Laboratory information system (LIS) database. Of the 41 bile duct margins in cases of ampullary tumours, 03 were positive on FS as well as PS, 35 were negative on FS as well as on PS. Results showed 100% sensitivity, 92.1% specificity, 50% PPV and 100% NPV. Results of 36 pancreatic margins in cases of ampullary showed 100% sensitivity, 97.1% specificity, 50% PPV and 100% NPV. In pancreatic carcinoma cases, none of CBD margins were reported as positive on FS, 02 margins reported as negative were found positive on PS, while 17 were negative on FS as well as PS. Results showed 100% specificity and 89.5% NPV. Of the 27 pancreatic margins tested in pancreatic tumours 100% sensitivity, 94.1% specificity, 88.9% PPV and 100% NPV was found. Factors such as absent prior tissue diagnosis and/or inflammatory processes make margin diagnosis difficult. However, a high concordance was observed between our FS and PS diagnosis.

Atlantic continental margin of the United States

USGS Publications Warehouse

Grow, John A.; Sheridan, Robert E.; Palmer, A.R.

1982-01-01

The objective of this Decade of North American Geology (D-NAG) volume will be to focus on the Mesozoic and Cenozoic evolution of the U.S. Atlantic continental margin, including the onshore coastal plain, related onshore Triassic-Jurassic rift grabens, and the offshore basins and platforms. Following multiple compressional tectonic episodes between Africa and North America during the Paleozoic Era that formed the Appalachian Mountains, the Mesozoic and Cenozoic Eras were dominated by tensional tectonic processes that separated Africa and North America. Extensional rifting during Triassic and Early Jurassic times resulted in numerous tensional grabens both onshore and offshore, which filled with nonmarine continental red beds, lacustrine deposits, and volcanic flows and debris. The final stage of this breakup between Africa and North America occurred beneath the present outer continental shelf and continental slope during Early or Middle Jurassic time when sea-floor spreading began to form new oceanic crust and lithosophere between the two continents as they drifted apart. Postrift subsidence of the marginal basins continued in response to cooling of the lithosphere and sedimentary loading.Geophysical surveys and oil-exploration drilling along the U.S. Atlantic continental margin during the past 5 years are beginning to answer many questions concerning its deep structure and stratigraphy and how it evolved during the rifting and early sea-floor-spreading stages of the separation of this region from Africa. Earlier geophysical studies of the U.S. continental margin used marine refraction and submarine gravity measurements. Single-channel seismic-reflection, marine magnetic, aeromagnetic, and continuous gravity measurements became available during the 1960s.

Managing Marginal School Employees: Applying Standards-Based Performance Measures

ERIC Educational Resources Information Center

Fields, Lynette; Reck, Brianne; Egley, Robert

2006-01-01

This book contains a collection of case studies that provide a variety of situations in managing or working with marginal employees in a school system. Managing Marginal School Employees will serve as a primary or companion text for administrator candidates or current administrators that include dilemmas for the student to think about, discuss,…

Deoxycholic Acid and the Marginal Mandibular Nerve: A Cadaver Study.

PubMed

Blandford, Alexander D; Ansari, Waseem; Young, Jason M; Maley, Bruce; Plesec, Thomas P; Hwang, Catherine J; Perry, Julian D

2018-06-04

One of the rare but serious complications observed with deoxycholic acid administration is damage to the marginal mandibular nerve. In this study, we evaluated if deoxycholic acid directly induces histologic damage to fresh cadaveric marginal mandibular nerve. A segment of marginal mandibular nerve was harvested from 12 hemifaces of 6 fresh cadavers. The nerve specimen was exposed to either 0.9% sterile saline for 24 h, deoxycholic acid (10 mg/ml) for 20 min, or deoxycholic acid (10 mg/ml) for 24 h. The nerve specimens were then fixed in glutaraldehyde for a minimum of 24 h. Toluidine blue stained sections were evaluated for stain intensity using light microscopy and color deconvolution image analysis. Supraplatysmal fat was harvested as a positive control and exposed to the same treatments as the marginal mandibular nerve specimens, then evaluated using transmission electron microscopy. Toluidine blue staining was less in the marginal mandibular nerve exposed to deoxycholic acid when compared to saline. The specimen exposed to deoxycholic acid for 24 h showed less toluidine blue staining than that of the nerve exposed to deoxycholic acid for 20 min. Transmission electron microscopy of submental fat exposed to deoxycholic acid revealed disruption of adipocyte cell membrane integrity and loss of cellular organelles when compared to specimens only exposed to saline. Deoxycholic acid (10 mg/ml) damages the marginal mandibular nerve myelin sheath in fresh human cadaver specimens. Direct deoxycholic acid neurotoxicity may cause marginal mandibular nerve injury clinically. This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .

Marginal Loss Calculations for the DCOPF

DOE Office of Scientific and Technical Information (OSTI.GOV)

Eldridge, Brent; O'Neill, Richard P.; Castillo, Andrea R.

2016-12-05

The purpose of this paper is to explain some aspects of including a marginal line loss approximation in the DCOPF. The DCOPF optimizes electric generator dispatch using simplified power flow physics. Since the standard assumptions in the DCOPF include a lossless network, a number of modifications have to be added to the model. Calculating marginal losses allows the DCOPF to optimize the location of power generation, so that generators that are closer to demand centers are relatively cheaper than remote generation. The problem formulations discussed in this paper will simplify many aspects of practical electric dispatch implementations in use today,more » but will include sufficient detail to demonstrate a few points with regard to the handling of losses.« less

Intraoperative Evaluation of Breast Tumor Margins with Optical Coherence Tomography

PubMed Central

Nguyen, Freddy T.; Zysk, Adam M.; Chaney, Eric J.; Kotynek, Jan G.; Oliphant, Uretz J.; Bellafiore, Frank J.; Rowland, Kendrith M.; Johnson, Patricia A.; Boppart, Stephen A.

2009-01-01

As breast cancer screening rates increase, smaller and more numerous lesions are being identified earlier, leading to more breast-conserving surgical procedures. Achieving a clean surgical margin represents a technical challenge with important clinical implications. Optical coherence tomography (OCT) is introduced as an intraoperative high-resolution imaging technique that assesses surgical breast tumor margins by providing real-time microscopic images up to 2 mm beneath the tissue surface. In a study of 37 patients split between training and study groups, OCT images covering 1 cm2 regions were acquired from surgical margins of lumpectomy specimens, registered with ink, and correlated with corresponding histological sections. A 17 patient training set used to establish standard imaging protocols and OCT evaluation criteria demonstrated that areas of higher scattering tissue with a heterogeneous pattern were indicative of tumor cells and tumor tissue, in contrast to lower scattering adipocytes found in normal breast tissue. The remaining 20 patients were enrolled into the feasibility study. Of these lumpectomy specimens, 11 were identified with a positive or close surgical margin and 9 were identified with a negative margin under OCT. Based on histological findings, 9 true positives, 9 true negatives, 2 false positives, and 0 false negatives were found, yielding a sensitivity of 100% and specificity of 82%. These results demonstrate the potential of OCT as a real-time method for intraoperative margin assessment in breast conserving surgeries. PMID:19910294

Bayesian analysis of the flutter margin method in aeroelasticity

DOE PAGES

Khalil, Mohammad; Poirel, Dominique; Sarkar, Abhijit

2016-08-27

A Bayesian statistical framework is presented for Zimmerman and Weissenburger flutter margin method which considers the uncertainties in aeroelastic modal parameters. The proposed methodology overcomes the limitations of the previously developed least-square based estimation technique which relies on the Gaussian approximation of the flutter margin probability density function (pdf). Using the measured free-decay responses at subcritical (preflutter) airspeeds, the joint non-Gaussain posterior pdf of the modal parameters is sampled using the Metropolis–Hastings (MH) Markov chain Monte Carlo (MCMC) algorithm. The posterior MCMC samples of the modal parameters are then used to obtain the flutter margin pdfs and finally the fluttermore » speed pdf. The usefulness of the Bayesian flutter margin method is demonstrated using synthetic data generated from a two-degree-of-freedom pitch-plunge aeroelastic model. The robustness of the statistical framework is demonstrated using different sets of measurement data. In conclusion, it will be shown that the probabilistic (Bayesian) approach reduces the number of test points required in providing a flutter speed estimate for a given accuracy and precision.« less

Critical thinking, self-esteem, and state anxiety of nursing students.

PubMed

Suliman, Wafika A; Halabi, Jehad

2007-02-01

This study aimed at exploring the existing predominant critical thinking disposition(s) of baccalaureate nursing students and the relationship among their critical thinking (CT), self-esteem (SE), and state anxiety (SA). Cross-sectional correlational design was utilized to achieve the said aim. A voluntary convenient sample consisted of first year (n=105) and fourth year (n=60) nursing students. The California Critical Thinking Disposition Inventory, Rosenberg Self-Esteem Scale, and Spielberger State Anxiety Inventory were used for data collection after their translation to Arabic language and test for validity and reliability. Descriptive and inferential statistics were used to analyze data. Results showed that both groups overall CT was marginal indicating no serious deficiency, their SE was average, and their SA was relatively high; they reported analyticity, open-mindedness, systematicity, inquisitiveness, and truth seeking as predominant critical thinking dispositions with no significant difference between them. However, the two groups were weak with significant difference on CT self-confidence (t=-2.053, df=136.904, p=.042) with beginning students reporting poorer level of CT self-confidence. Significant correlation results showed that critical thinking is positively correlated with SE, negatively correlated with SA, and SE is negatively correlated with SA; however, all correlations were actually quite low.

Marginality and Variability in Esperanto.

ERIC Educational Resources Information Center

Brent, Edmund

This paper discusses Esperanto as a planned language and refutes three myths connected to it, namely, that Esperanto is achronical, atopical, and apragmatic. The focus here is on a synchronic analysis. Synchronic variability is studied with reference to the structuralist determination of "marginality" and the dynamic linguistic…

[Microbiological testing of the artificial gingival margin in dentures].

PubMed

Hermann, Péter; Klein, Ildikó; Barna, Zsuzsanna; Kaán, Miklós; Fejérdy, Pál

2004-06-01

In everyday practice dental laboratories try to reproduce the natural form of sulcus gingivae at the transitional area between artificial teeth and gingiva of removable dentures, even on esthetically less important areas. Aim of these investigations were to examine how artificial recreation of the sulcus gingivae influences plaque retention, and what is the microbiological relevance of these. Investigations were carried out on the vestibular side of removable dentures of 32 randomly selected patients treated at the Department of Prosthodontics at the Faculty of Dentistry, Semmelweis University. Microbiological samples were taken from each patient using the same method. Samples were taken from the left upper first molars' artificial gingival margin using sterile paper points. Paper points were then transported in Eppendorf-tubes, in 2 ml of physiological saline solution, and processed within a two-hour period of time. Series dilutions were made of the sample solutions, then surface-streaked on Subaraud and Gentamycin, blood-agar, eosin-methylene blue and Mitis Salivarius culture enriched with Bacitracin. Subaraud culture was induced under aerob conditions, at room temperature for two days, then the total amount of fungi quantified. After pure-culturing Candida albicans ID-culture was used for identification, and BioMerieux ATB automatic equipment to identify different Candida species. From pure cultures identification was carried out with Gram-staining, Neisser-staining, catalase, oxidase and also with other biochemical reactions. Blood-agar was used to determine total germ count, and normal commensal pharyngeal and oral bacteria. After collecting the microbiological samples, the conventional shape of the dental margin of gingiva was abolished on one side of the dentures and a smooth transition was created between denture teeth and the artificial gingiva in the molar and premolar region. During our investigations only blastomycetes were found. Besides most common

Fighting, Loving, Teaching: An Exploration of Hope, Armed Love and Critical Pedagogies in Urban Teachers' Praxis

ERIC Educational Resources Information Center

Daniels, Emily

2010-01-01

The purpose of this study was to explore urban teachers' praxis with historically marginalized youth. Specifically I examined of the role of hope and armed love, as well as critical pedagogy as conceptualized and implemented in urban classrooms. The basis for this is the continued educational inequities for urban youth, and an exploration of the…

Magma-poor and magma-rich segments along the hyperextended, pre-Caledonian passive margin of Baltica

NASA Astrophysics Data System (ADS)

Andersen, Torgeir B.; Alsaif, Manar; Corfu, Fernando; Jakob, Johannes; Planke, Sverre; Tegner, Christian

2015-04-01

the pre-Caledonian margin of Baltica underwent hyperextension until break-up, which was associated with emplacement of a LIP at ~600 Ma in the central segment. Andersen, T.B., Labrousse, L., Corfu, F. and Osmundsen, P.T., 2012: Evidence for hyperextension along the pre-Caledonian margin of Baltica. Jl. Geol. Soc. London, 601-612 Baird, G.B., Figg, SA. and Chamberlain, K.R., 2014: Intrusive age and geochemistry of the Kebne Dyke Complex in the Seve Nappe Complex, Kebnekaise Massif, arctic Sweden Caledonides, GFF, doi: 10.1080/11035897.2014.924553 Corfu, F., Andersen, T.B. and Gasser, D., 2014: The Scandinavian Caledonides: main features, conceptual advances and critical questions. Geol. Soc. London Spec. Publ. 390 doi:10.1144/SP390.25 Hollocher. K, Robinson, P., Walsh, E. and Terry M.P., 2007:The Neoproterozoic Ottfjellet dike swarm of the Middle Allochthon, traced geochemically into the hinterland, Western Gneiss Region, Norway. Am. Jl. Sci. 307, 901-953 Svenningsen, O., 2001: Onset of seafloor spreading in the Iapetus Ocean at 608Ma: precise age of the Sarek Dyke Swarm, northern Swedish Caledonides. Precambrian Res., 110, 241-254.

Revealing the long-term landscape evolution of the South Atlantic passive continental margin, Brazil and Namibia, by thermokinematic numerical modeling using the software code Pecube.

NASA Astrophysics Data System (ADS)

Stippich, Christian; Glasmacher, Ulrich Anton; Hackspacher, Peter

2015-04-01

The aim of the research is to quantify the long-term landscape evolution of the South Atlantic passive continental margin (SAPCM) in SE-Brazil and NW-Namibia. Excellent onshore outcrop conditions and complete rift to post-rift archives between Sao Paulo and Porto Alegre and in the transition from Namibia to Angola (onshore Walvis ridge) allow a high precision quantification of exhumation, and uplift rates, influencing physical parameters, long-term acting forces, and process-response systems. Research will integrate the published and partly published thermochronological data from Brazil and Namibia, and test lately published new concepts on causes of long-term landscape evolution at rifted margins. The climate-continental margin-mantle coupled process-response system is caused by the interaction between endogenous and exogenous forces, which are related to the mantle-process driven rift - drift - passive continental margin evolution of the South Atlantic, and the climate change since the Early/Late Cretaceous climate maximum. Special emphasis will be given to the influence of long-living transform faults such as the Florianopolis Fracture Zone (FFZ) on the long-term topography evolution of the SAPCM's. A long-term landscape evolution model with process rates will be achieved by thermo-kinematic 3-D modeling (software code PECUBE1,2 and FastScape3). Testing model solutions obtained for a multidimensional parameter space against the real thermochronological and geomorphological data set, the most likely combinations of parameter rates, and values can be constrained. The data and models will allow separating the exogenous and endogenous forces and their process rates. References 1. Braun, J., 2003. Pecube: A new finite element code to solve the 3D heat transport equation including the effects of a time-varying, finite amplitude surface topography. Computers and Geosciences, v.29, pp.787-794. 2. Braun, J., van der Beek, P., Valla, P., Robert, X., Herman, F., Goltzbacj

A Causal Relation between Bioluminescence and Oxygen to Quantify the Cell Niche

PubMed Central

Lambrechts, Dennis; Roeffaers, Maarten; Goossens, Karel; Hofkens, Johan; Van de Putte, Tom; Schrooten, Jan; Van Oosterwyck, Hans

2014-01-01

Bioluminescence imaging assays have become a widely integrated technique to quantify effectiveness of cell-based therapies by monitoring fate and survival of transplanted cells. To date these assays are still largely qualitative and often erroneous due to the complexity and dynamics of local micro-environments (niches) in which the cells reside. Here, we report, using a combined experimental and computational approach, on oxygen that besides being a critical niche component responsible for cellular energy metabolism and cell-fate commitment, also serves a primary role in regulating bioluminescent light kinetics. We demonstrate the potential of an oxygen dependent Michaelis-Menten relation in quantifying intrinsic bioluminescence intensities by resolving cell-associated oxygen gradients from bioluminescent light that is emitted from three-dimensional (3D) cell-seeded hydrogels. Furthermore, the experimental and computational data indicate a strong causal relation of oxygen concentration with emitted bioluminescence intensities. Altogether our approach demonstrates the importance of oxygen to evolve towards quantitative bioluminescence and holds great potential for future microscale measurement of oxygen tension in an easily accessible manner. PMID:24840204

A causal relation between bioluminescence and oxygen to quantify the cell niche.

PubMed

Lambrechts, Dennis; Roeffaers, Maarten; Goossens, Karel; Hofkens, Johan; Vande Velde, Greetje; Van de Putte, Tom; Schrooten, Jan; Van Oosterwyck, Hans

2014-01-01

Bioluminescence imaging assays have become a widely integrated technique to quantify effectiveness of cell-based therapies by monitoring fate and survival of transplanted cells. To date these assays are still largely qualitative and often erroneous due to the complexity and dynamics of local micro-environments (niches) in which the cells reside. Here, we report, using a combined experimental and computational approach, on oxygen that besides being a critical niche component responsible for cellular energy metabolism and cell-fate commitment, also serves a primary role in regulating bioluminescent light kinetics. We demonstrate the potential of an oxygen dependent Michaelis-Menten relation in quantifying intrinsic bioluminescence intensities by resolving cell-associated oxygen gradients from bioluminescent light that is emitted from three-dimensional (3D) cell-seeded hydrogels. Furthermore, the experimental and computational data indicate a strong causal relation of oxygen concentration with emitted bioluminescence intensities. Altogether our approach demonstrates the importance of oxygen to evolve towards quantitative bioluminescence and holds great potential for future microscale measurement of oxygen tension in an easily accessible manner.

Mapping Mesophotic Reefs Along the Brazilian Continental Margin

NASA Astrophysics Data System (ADS)

Bastos, A.; Moura, R.; Amado Filho, G.; Ferreira, L.; Boni, G.; Vedoato, F.; D'Agostini, D.; Lavagnino, A. C.; Leite, M. D.; Quaresma, V.

2017-12-01

Submerged or drowned reefs constitute an important geological record of sea level variations, forming the substrate for the colonization of modern benthic mesophotic communities. Although mapping mesophotic reefs has increased in the last years, their spatial distribution is poorly known and the worldwide occurrence of this reef habitat maybe underestimated. The importance in recognizing the distribution of mesophotic reefs is that they can act as a refuge for corals during unsuitable environmental conditions and a repository for shallow water corals. Here we present the result of several acoustic surveys that mapped and discovered new mesophotic reefs along the Eastern and Equatorial Brazilian Continental Margin. Seabed mapping was carried out using multibeam and side scan sonars. Ground truthing was obtained using drop camera or scuba diving. Mesophotic reefs were mapped in water depths varying from 30 to 100m and under distinct oceanographic conditions, especially in terms of river load input and shelf width. Reefs showed distinct morphologies, from low relief banks and paleovalleys to shelf edge ridges. Extensive occurrence of low relief banks were mapped along the most important coralline complex province in the South Atlantic, the Abrolhos Shelf. These 30 to 40m deep banks, have no more than 3 meters in height and may represent fringing reefs formed during sea level stabilization. Paleovalleys mapped along the eastern margin showed the occurrence of coralgal ledges along the channel margins. Paleovalleys are usually deeper than 45m and are associated with outer shelf rhodolith beds. Shelf edge ridges (80 to 120m deep) were mapped along both margins and are related to red algal encrusting irregular surfaces that have more than 3m in height, forming a rigid substrate for coral growth. Along the Equatorial Margin, off the Amazon mouth, shelf edge patch reefs and rhodolith beds forming encrusting surfaces and shelf edge ridges were mapped in water depths greater

Geochronological (OSL) and geomorphological investigations at the presumed Frankfurt ice marginal position in northeast Germany

NASA Astrophysics Data System (ADS)

Hardt, Jacob; Lüthgens, Christopher; Hebenstreit, Robert; Böse, Margot