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1

Newton-Algorithmen zur Bestimmung von Nullstellen mit Fehlerschranken  

Microsoft Academic Search

In der vorliegenden Arbeit werden zunächst Definitionen und Eigenschaften von Intervall-Normen und-Spannen behandelt. Sodann werden einigeNewton-Algorithmen zur Bestimmung von Nullstellen einer Funktion mit einer Veränderlichen angegeben. Diese Algorithmen liefern mit Hilfe einer Intervallarithmetik als Ergebnis ein Intervall, in dem die exakte Nullstelle liegt. Eine Verallgemeinerung der Algorithmen zur Lösung eines Gleichungssystems wird ebenfalls hergeleitet.

Rudolf Krawczyk

1969-01-01

2

Zur Spektralphotometrischen Bestimmung von Natamycin auf Käse  

Microsoft Academic Search

Summary Derivative spectroscopy was used for quantitative determination of natamycin in cheese. When measuring a methanolic cheese extract against methanol, the second derivative of the UV-spectrum is measured between 340 and 290 nm. The natamycin concentration can be determined by measuring the vertical distance between the minimum at 318 nm and the maximum at 311 nm.

Robert Riedl; Wolfgang Luf; Ernst Brandl

1984-01-01

3

GC-MS-Bestimmung von Ethylglucuronid im Serum mit Propylglucuronid als internem Standard  

Microsoft Academic Search

Zusammenfassung   Es werden die chromatographischen Eigenschaften von Acetyl- und PFP- (Perfluorpropionyl-) derivaten einiger synthetisch dargestellter\\u000a Alkylglucuronide auf einer OV-1-Kapillarsule sowie die massenspektrometrischen Daten mitgeteilt. Die homologen Derivate zeigen\\u000a weitgehende bereinstimmung im Fragmentierungsmuster. Es wird hieraus auf die Struktur von Diacyl-alkylglucuronidlactonen\\u000a geschlossen. Es wird die Bestimmung von Ethylglucuronid als PFP-Derivat im Serum unter Zusatz von 20 mg\\/L Propylglucuronid\\u000a als innerem Standard

G. Sticht; H. Käferstein; M. Staak

1997-01-01

4

Quantitative photometrische Bestimmung der Pyrrolizidinalkaloide in Symphity Radix  

Microsoft Academic Search

A colour reaction for unsaturated pyrrolizidine alkaloids (PAs), which has already been published, is used for spectrophotometric determination of the toxic PAs in Symphyti Radix (Symphytum officinale L., Boraginaceae). By changing several parameters it was possible to reduce the detection limit to 1 microgram and to improve significantly the reproducibility of the quantitative determination. For Symphyti Radix a simple extraction

Erhard Roeder; Ke Liu; Reinhard Mütterlein

1992-01-01

5

Hochleistungsflüssigchromatographische Bestimmung von organischen Säuren, Zuckern, Glycerin und Alkohol im Wein an einer Kationenaustauschersäule  

Microsoft Academic Search

Summary The main constituents of wine (ethanol, glycerol, glucose, fructose, tartrate, malate, lactate, succinate, acetate and citrate) were separated by HPLC in one run and determined quantitatively in a time of 25 min. The stationary phase was the cation exchange resin HPX 87H and the mobile phase was dilute sulfuric acid. The results of the HPLC analysis of several wines

Peter Pfeiffer; Ferdinand Radler

1985-01-01

6

Enzymatische Bestimmung von Lactulose  

Microsoft Academic Search

Summary Lactulose is hydrolyzed byß-d-galactosidase fromE. coli to form galactose and fructose. The last one is determined with the use of hexokinase\\/glucose-6-phosphate-dehydrogenase and phosphoglucose-isomerase. Glucose derived from lactose byß-galactosidase is removed from the samples before fructose determination by glucose-oxidase and catalase.

Hermann Geier; Henning Klostermeyer

1980-01-01

7

Die spezifische Extraktion von Uran(VI) mit N-Benzylanilin und N-Butylanilin  

Microsoft Academic Search

Zusammenfassung Zwei Methoden zur extraktiven Abtrennung des Urans von einer Reihe von Ionen werden beschrieben. Die Extraktion erfolgt aus schwefelsaurer Lösung mit N-Benzylanilin bzw. N-Butylanilin, gelöst in Chloroform. Nach Reextraktion mit Wasser erfolgt die quantitative Bestimmung mit PAR.

E. Gagliardi; B. Ilmaier

1968-01-01

8

Bestimmung des Niob mit PAN nach Extraktion mit N-Benzylanilin  

Microsoft Academic Search

Zusammenfassung Die spektralphotometrische Bestimmung des Niob mit PAN wird beschrieben. Der rotviolette Komplex bildet sich in der Wärme bei pH 2 voll aus. Um Störungen durch Fremdionen auszuschalten, wird das Metall mit N-Benzylanilin—Chloroform in schwefelsaurer Lösung extra-hiert und im organischen Solvens der Niob-PAN-Komplex gemessen. Niob läßt sich so von allen Metallen abtrennen und quantitativ bestimmen. Eine Arbeitsvorschrift für die Bestimmung

E. Gagliardi; E. Wolf

1967-01-01

9

Intracellular Storage and Regulated Secretion of Von Willebrand Factor in Quantitative Von Willebrand Disease*  

PubMed Central

Several missense mutations in the von Willebrand Factor (VWF) gene of von Willebrand disease (VWD) patients have been shown to cause impaired constitutive secretion and intracellular retention of VWF. However, the effects of those mutations on the intracellular storage in Weibel-Palade bodies (WPBs) of endothelial cells and regulated secretion of VWF remain unknown. We demonstrate, by expression of quantitative VWF mutants in HEK293 cells, that four missense mutations in the D3 and CK-domain of VWF diminished the storage in pseudo-WPBs, and led to retention of VWF within the endoplasmic reticulum (ER). Immunofluorescence and electron microscopy data showed that the pseudo-WPBs formed by missense mutant C1060Y are indistinguishable from those formed by normal VWF. C1149R, C2739Y, and C2754W formed relatively few pseudo-WPBs, which were often short and sometimes round rather than cigar-shaped. The regulated secretion of VWF was impaired slightly for C1060Y but severely for C1149R, C2739Y, and C2754W. Upon co-transfection with wild-type VWF, both intracellular storage and regulated secretion of all mutants were (partly) corrected. In conclusion, defects in the intracellular storage and regulated secretion of VWF following ER retention may be a common mechanism underlying VWD with a quantitative deficiency of VWF.

Wang, Jiong-Wei; Valentijn, Karine M.; de Boer, Hetty C.; Dirven, Richard J.; van Zonneveld, Anton Jan; Koster, Abraham J.; Voorberg, Jan; Reitsma, Pieter H.; Eikenboom, Jeroen

2011-01-01

10

Nachweis und Charakterisierung von Schwangerschaftsproteinen in der menschlichen Placenta, sowie ihre quantitative immunologische Bestimmung im Serum schwangerer Frauen  

Microsoft Academic Search

Summary In sera from pregnant women 4 different pregnancy proteins could be detected by the Ouchterlony gel diffusion technique with antisera which have been prepared by immunizing rabbits with protein fractions from human placentas.

H. Bohn

1971-01-01

11

Die pharmakologische Gehaltsbestimmung von Strophanthinlösungen  

Microsoft Academic Search

Zusammenfassung 1.Es wurde ein Verfahren ausgearbeitet zur pharmakologischen Gehaltsbestimmung von Strophanthinlösungen am isolierten Herzen von Temporarien.2.Das Verfahren am isolierten Herzen wurde durch Versuche mit Injektion von Strophanthinlösungen am ganzen Frosch auf seine Exaktheit nachgeprüft.3.Temporarienherzen sind empfindlicher gegen Strophanthin als die von Eskulenten und können zur pharmakologischen Bestimmung besser verwendet werden. Zu dem Verfahren können auch weibliche Tiere benutzt und die

Hans Fasching

1930-01-01

12

Quantitative Beziehungen zwischen den Eigenschaften von Futterquellen und dem Verhalten von Sammelbienen  

Microsoft Academic Search

1.Bei unbeschränktem Nachfluß von Zuckerwasser trinkt eine Sammelbiene bei jedem Besuch um so mehr, d.h. sie erreicht eine um so größere „Abflugmagenfüllung“, je konzentrierter die angebotene Zuckerlösung ist (Abb. 5 und 5a)2.Die Trink-Geschwindigkeit bei unbeschränktem Nachfluß ist bei niederen und mittleren Zuckerkonzentrationen gleich groß (Abb 6); bei hohen Konzentrationen sinkt sie etwas ab, vermutlich wegen der größeren Viskosität konzentrierter Zuckerlösungen.3.Wird

Josué A. Núñez

1966-01-01

13

Real-time Quantitative X-Ray Spectroscopy with a von Hamos Spectrometer  

NASA Astrophysics Data System (ADS)

The real-time quantitative spectroscopy of laser-produced plasmas is explored using a compact von Hamos spectrometer and linear CCD array. This system provides excellent spectral resolution and high dynamic range for compact x-ray sources. Possible uses of this spectrometer include applications in x-ray lithography and laser produced plasma diagnostics.

Weeks, Tyler; Johnson, Michael; Raymond, Scott; Johnson, Jon Paul; Knight, Larry; Shevelko, Alexander

2004-10-01

14

Bestimmung von Zuckern mit dem Auto Analyzer  

Microsoft Academic Search

An automatic method is described for the determination of sugars in fermentation solutions by means of the Technicon AutoAnalyzer. A solution of cysteine hydrochloride in conc. sulphuric acid is employed as reagent. Up to 30 samples can be analysed within 1 hour. The method has to be tested by a fermentation experiment in the case of a mixture of several

K. Buchta

1967-01-01

15

Bestimmung von isomeren 4-Nonylphenolen in Böden  

Microsoft Academic Search

Summary  It was reported that 4-nonylphenol isomers had been found in high concentrations in sewage sludge. When this sludge is applied to fields there is a risk that soils may be contaminated with nonylphenols. Therefore, a method is described here for the determination of 4-nonylphenol isomers in soil. The steam distillation\\/solvent extraction technique is used. An essential part of the method

Helmuth Jobst

1987-01-01

16

Bestimmung von Ochratoxin A in Muttermilch  

Microsoft Academic Search

Summary A method for the determination of ochratoxin A in milk is described. The milk is homogenized in a buffer solution at pH 1.6 to release ochratoxin A from its bond to proteins. Ochratoxin A is extracted with chloroform and the extract cleaned up using a base clean-up step. Analysis is performed by high-pressure liquid chromatography, using a reversed-phase column

Manfred Gareis; Erwin Märtlbauer; Johann Bauer; Brigitte Gedek

1988-01-01

17

Radioimmunologische Bestimmung von Digoxin im Urin  

Microsoft Academic Search

Summary When separating free and antibody bound digoxin, dextrancoated charcoal suspensions in protein-free urine dilutions develop an improves sieve effect which improves with aging of the suspensions. On addition of albumin to the dilution medium (buffer), the adsorptive capacities become stabilized. In urine dilutions < of 1:50, false positive digoxin concentrations were measured. Determinations of 0–5 ng digoxin\\/ml in the

K. Maertin; N. Rietbrock

1977-01-01

18

Über die Auswertung von Leitfähigkeitsglowkurven  

Microsoft Academic Search

Es wird für ein einfaches reaktionskinetisches Modell mit einer Hafttermgruppe einheitlicher energetischer Lage der Verlauf der Lösungsfunktionen des ihm entsprechenden Gleichungssystems diskutiert, unter gewissen Näherungsannahmen eine Methode zur Bestimmung physikalisch interessierender Parameter aus Leitfähigkeitsglowkurven angegeben und eine Fehlerabschätzung für die nach dieser Methode bestimmten Parameter durchgeführt. Es ergibt sich überdies, daß die Näherungsformel von Randall und Wilkins auch für Leitfähigkeitsglowkurven

K. W. Böer; S. Oberländer; J. Voigt

1958-01-01

19

Pheromonfallen zur Bestimmung des Apfelwicklerfluges  

Microsoft Academic Search

Zusammenfassung  Pheromonfallen zur Prognose von Wicklerflügen im Obstbau werden seit 1971 in Süddeutschland verwendet. Die Fallen- und Anwendungstechniken\\u000a sowie die Ergebnisse von dreijährigen Freilandversuchen mit Lockstoffen beim ApfelwicklerLaspeyresia pomonella L. im Vergleich zu Lichtfallen werden vorgestellt. Dabei sind synthetische Lockstoffe fängiger als lebende Weibchen. Die\\u000a Fangmethode hat sich im Apfelwicklerwarndienst zur Feststellung des örtlichen und zeitlichen Flugverlaufs bewährt und kann\\u000a nun

G. Neuffer

1974-01-01

20

Lebensdauervorhersage. Anwendbarkeit von ZFP-Methoden zur quantitativen Bestimmung von Kriechschaedigung an betriebsbeanspruchten Kraftwerkskomponenten. Abschlussbericht. (Prediction of service life. The applicability of NDT methods for the quantitative determination of creep damage to power station components stressed in operation. Final report).  

National Technical Information Service (NTIS)

In the context of the combined project, a foundation is to be marked out which, based on damage analysis, should lead to an improvement of the estimation of the remaining service life of powerstation components. The programme of work includes the main poi...

W. Bendick

1992-01-01

21

Remissionsspektrometrische Bestimmung von Vitamin D in diätetischen Lebensmitteln  

Microsoft Academic Search

Summary This method deals with the determination of vitamin D in dietetic food, specially in baby food. For this purpose normally 4 clean-up resp. enrichment steps are necessary (extraction, saponification, liquid-solid chromatography and TLC), followed by the determination of vitamin D by means of reflectance spectroscopy.

Werner Meine

1980-01-01

22

Bestimmung von Epoxyendgruppen in modifizierten chromatographischen Sorbentien und Gelen  

Microsoft Academic Search

The addition of hydrogen chloride from solutions of pyridinium chloride in pyridine, or from solutions of hydrogen chloride in dioxan or in methylcellosolve, as well as the addition of thiosulphate and the direct non-aqueous titration with perchloric acid in the presence of tetraethylammonium bromide were studied and applied for the determination of bound epoxy groups in epoxidized silicagels and the

M. P?ibyl

1980-01-01

23

Eine neue Bestimmung der Neutralfette im Blutserum und Gewebe  

Microsoft Academic Search

Zusammenfassung Die Reproduzierbarkeit beträgt für die enzymatische Bestimmung des „freien“ Glycerins 2,6%, für „Gesamtglycerin“ rund 3,1% und „Glyceridglycerin“ rund 3,4%. Als Wiederholungsfehler wurden 2,5%, 2,1% und 2,2% bestimmt.

M. Eggstein

1966-01-01

24

Compact focusing von Hamos spectrometer for quantitative x-ray spectroscopy  

NASA Astrophysics Data System (ADS)

A compact focusing crystal spectrometer based on the von Hamos scheme is described. Cylindrically curved mica and graphite crystals with a radius of curvature of R=20 mm are used in the spectrometer. A front illuminated charge-coupled device (CCD) linear array detector makes this spectrometer useful for real-time spectroscopy of laser-produced plasma x-ray sources within the wavelength range of ?=1.8-10 Å. Calibration of crystals and the CCD linear array makes it possible to measure absolute photon fluxes. X-ray spectra in an absolute intensity scale were obtained from Mg, Ti, and Fe laser-produced plasmas, with a spectral resolution ?/??=800-2000 for the mica and ?/??=200-300 for graphite crystal spectrometers. The spectrometer has high efficiency in a wide spectral range, it is compact (40 mm diam, 150 mm length), easy to align, and flexible. The spectrometer is promising for absolute spectral measurements of x-ray radiation of low-intensity sources (femtosecond laser-produced plasmas, micropinches, electron-beam-ion-trap sources, etc.).

Shevelko, A. P.; Kasyanov, Yu. S.; Yakushev, O. F.; Knight, L. V.

2002-10-01

25

Quantitative determination of ultra-traces of chlorinated compounds in high-volume air samples from the Arctic using polyurethane foam as collection medium  

Microsoft Academic Search

Das beschriebene Verfahren dient zur Bestimmung von chlorierten Verbindungen (chlorierte Benzole, Hexachlorcyclohexane, polychlorierte Biphenyle, DDT-Gruppe) in niedrigen Konzentrationen (pg\\/m3) in Luft. Da die meisten dieser Verbindungen gasförmig vorkommen, wurde eine Probenahmemethode für große Volumina unter Verwendung von sorgfältig vorgereinigtem Polyurethanschaum als Adsorptionsmedium entwickelt. Proben von 2000–4000 m3 wurden an verschiedenen Stellen der Arktis genommen. Die Vorbehandlung des Schaums und der

M. Oehme; H. Stray

1982-01-01

26

Laboratory diagnosis of von Willebrand disease  

Microsoft Academic Search

Von Willebrand disease is the most-common inherited bleeding disorder, including both quantitative (types 1 and 3) and qualitative\\u000a (type 2) defects of von Willebrand factor. Among patients with suspected von Willebrand disease, the laboratory diagnosis\\u000a requires three levels of testing: screening tests, specific assays for von Willebrand factor to establish the diagnosis, and\\u000a discriminating tests to allow accurate characterization of

A. Veyradier; E. Fressinaud; D. Meyer

1998-01-01

27

Löslichkeitskonstanten und freie Bildungsenthalpien von Metallsulfiden, 4. Mitt.: Die Löslichkeit von H 2 S in HClO 4 ?NaClO 4 ?H 2 O-Mischungen  

Microsoft Academic Search

Zusammenfassung Die Löslichkeit von H2S bei 25°C in Lösungsmitteln der Zusammensetzung: [H+]=HM, [Na+]=(I-H)=AM, [ClO4-]=IM wurde durch jodometrische Bestimmung von [H2S]tot in den gesättigten Lösungen untersucht. Kp12=[H2S]tot·pH2S-1 wurde berechnet. Die Ergebnisse lassen sich durch folgende Gleichung wiedergeben.\\u000a$$\\\\begin{gathered} \\\\lg [H_2 S]_{tot} \\\\cdot p_{H_2 S}^{ - 1} = --- 0,991_8 --- 0,059_0 [Na + ] + 0,008_1 [H + ]--- \\\\hfill \\\\\\\\

H. Gamsjäger; W. Rainer; P. Schindler

1967-01-01

28

Zur stufenphotometrischen bestimmung des kreatinins in plasma und urin mit hilfe der m-dinitrobenzoesÄure  

Microsoft Academic Search

Zusammenfassung  Vorangehend sind die Reaktionsbedingungen fr die stufenphotometrische Bestimmung des Kreatinins mit Hilfe der m-Dinitrobenzoesure\\u000a eingehend erlutert worden. Es folgt nun stichwortartig die Beschreibung des ganzen Reaktionsverlaufes.\\u000a \\u000a \\u000a A. \\u000a \\u000a Bestimmung des Kreatinins im Plasma. 12 ccm Plasma + gleiche Menge 10% Trichloressigsure werden unter Umschtteln gemischt\\u000a und hierauf 5 Min. stehen gelassen. Hierauf Filtration. Zu 10 ccm Filtrat wird tropfenweise 10% NaOH

M. Gukelberger; V. Wy?

1942-01-01

29

Quantitative Analyse von Korallengemeinschaften des Sanganeb-Atolls (mittleres Rotes Meer). I. Die Besiedlungsstruktur hydrodynamisch unterschiedlich exponierter Außen- und Innenriffe  

NASA Astrophysics Data System (ADS)

The Sanganeb-Atoll off Port Sudan is an elongate annular reef which rests on a probably raised block in the fracture zone along the Red Sea-graben. Its gross morphology was most likely formed by subaerial erosion during low sealevel conditions. Features of its topography and hydrography are described. The prevailing wind waves are from NE, Hence, the outer and inner reef slopes are exposed to different hydrodynamic conditions. The sessile benthos was analysed using the quadrat method. Four test quadrats (5×5 m each) were selected on the outer and inner slopes at a depth of 10 m along a SSW-NNE transect across the atoll. Cnidaria were by far the most dominating group; coralline algae, Porifera, Bryozoa and Ascidia, however, counted for just under 3 % living cover. Light and temperature intensities did not differ significantly at the sites studied; water movement, however, decreased in the following order: TQ IV (outer NE side of the reef ring) was exposed to strong swell and surf; TQ II (inner side of the SW-ring) was met by a strong longreef current; TQ I was situated on the outer lee of the SW-atoll ring and TQ III in the inner lee of the NE-side. This hydrodynamic gradient correlates with the composition of the coral communities from predominantly branching Scleractinia (staghorn-like and other Acropora species and Pocillopora) in TQ IV, through a Lobophyllia, Porites and Xenia-dominated community in TQ II, and a mixed community with an increasing percentage of xeniid and alcyoniid soft corals in TQ I, to a community in TQ III which is dominated by the soft corals Sinularia and Dendronephthya. The cnidarian cover ranged between 42.4 and 56.6 % whereby the two exposed test quadrats had a higher living coverage than the protected ones. In total, 2649 colonies comprising 124 species of stony, soft and hydrocorals were recorded by an elaborate method of accurate in-situ mapping. The 90 scleractinian species found include 3 species new to the Red Sea and 11 hitherto unknown species from its central part. Only 7 cnidarian species covered large areas, forming a Xenia macrospiculata-zone in TQ I, a Lobophyllia corymbosa-zone in TQ II, a Sinularia-Dendronephthya-zone in TQ III and an Acropora-Pocillopora verrucosa-zone in TQ IV. Hydrodynamic exposition and ratio of genus abundance Acropora: Montipora are closely correlated: on the windward side (TQ IV) it is 943:4, but on the leeward side (TQ I) 18:208. Apart from the taxonomic and quantitative distribution of species and colonies, types of growth form and categories of the dead substrate are given. Since soft corals do not contribute to the reef framework, the distribution of Scleractinia and Alcyonaria indicates that at Sanganeb-Atoll reef substance is mainly generated on the windward side.

Mergner, H.; Schuhmacher, H.

1985-12-01

30

Die Biologische Bestimmung von lactotropem Hormon (LTH) und ihre Anwendbarkeit beim Menschen  

Microsoft Academic Search

The local pigeon crop sac assay according to Grosvenor and Turner (1958) and Nicoll (1967) was used to rate human material for LTH-potencies. Histological investigations showed that fat vacuolisation of the proliferating crop sac epithelium is a specific parameter for LTH activity. Therefore it is required to run a histological confirmation, if crude materials are assayed.

I. Berswordt-Wallrabe; U. Herlyn; D. Flaskamp; G. Hellige

1971-01-01

31

Zur Duennschichtchromatographischen Bestimmung von Trichothecen-Toxinen (Thin Layer Chromatographic Determination of Trichthecene Toxins).  

National Technical Information Service (NTIS)

The existing AC-Lab Operational Guidelines for trichothecene toxin determination is to be supplemented by a simple selective proof method. This procedure involves spraying the thin layer chromatogramm with sulfuric acid after development and subjecting it...

B. Zehnder

1984-01-01

32

Zur Quantitativen Bestimmung von Stickoxiden im Zigarettenrauch mit Hilfe der Chemilumineszenzmethode  

Microsoft Academic Search

Summary A measuring method with a chemiluminescence-analyzer is developed for determining the content of nitrogen oxide in cigarette smoke. This method is suitable for puff\\/puff analysis. It could be demonstrated that a determination of fresh smoke is necessary as nitrogen oxides react very quickly with other constituents of the vapor phase. Measured values have to be corrected for a quench

Hans-Joachim Klimisch; Emanuel Kirchheim

1977-01-01

33

Radon222 – ein neuer Leitkennwert zur Bestimmung optimaler Abpumpzeiten von Grundwassermeßstellen  

Microsoft Academic Search

Kurzfassung  \\u000a \\u000a Es wurde ein neues Verfahren zur Optimierung des Zeitpunktes für eine repräsentative Probenahme aus Grundwassermeßstellen\\u000a auf der Basis der natürlichen Radonkativitätskonzentration des Grundwassers entwickelt. Bisher wurden hierzu die Meßwertkonstanz\\u000a der Leitkennwerte elektrische Leitfähigkeit, Temperatur und pH-Wert sowie die mehrfache Erneuerung des Standardwesens als\\u000a Kriterien herangezogen. Das neue Verfahren ist gut reproduzierbar. Es führt zur Verkürzung der Abpumpzeiten und reduziert

Jörg Dehnert; Wolfgang Nestler; Klaus Freyer; Hanns-Christian Treutler; Peter Neitzel; Wolfgang Walther

1997-01-01

34

Verfahren zur hochgenauen Bestimmung des Reflexionsvermögens von Laserspiegeln in einer Resonatoranordnung  

NASA Astrophysics Data System (ADS)

Wird auf geeignete Weise ein hochfrequent amplitudenmodulierter Laserstrahl geringer Linienbreite in einen passiven Resonator gekoppelt, bewirken die Resonatorgeometrie und die Reflexionsvermögen R1 und R2 der Resonatorspiegel eine Phasenverschiebung des Modulationssignales bezüglich eines Referenzstrahles.Durch zeitlineare Resonatorlängenänderung wird eine zeitabhängige Phasenverschiebung erzeugt, der das Produkt R1 R2 eindeutig zu entnehmen ist.Translated AbstractMethod for Accurate Determination of the Reflectivity of Laser Mirrors in an Optical CavityIf a high frequency intensity chopped laser beam is passing a passive optical resonator a phase lag between its output and input signal results. Due to the limited photon lifetime inside the resonator the measurable phase lag is determined by resonator length and mirror reflectivities.Changing the resonator length in a time-proportional regime a time dependent phase lag results from which the product of mirror reflectivities is calculable unambiquously.

Fiedler, Roland; Schirmer, Gustav; Schubert, Dieter; Walther, Heinz-Günter

35

Evolutionäre Algorithmen zur Topologieentwicklung von Neuronalen Netzen für die Roboter-Navigation im praktischen Einsatz  

NASA Astrophysics Data System (ADS)

Eine wichtige Frage in der mobilen Robotik ist die sichere Navigation in unbekannten Umgebungen unter der Anwendung preiswerter Sensorik. Solch eine Navigation kann ein künstliches Neuronales Netz (kNN) übernehmen, welches die Kopplung der Sensoren des Roboters mit dessen Antriebssystem herstellt. "Neuro Evolution of Augmenting Topologies“ (NEAT) von Stanley und Miikkulainen [1] verwendet den Evolutionären Ansatz sowohl für die Topologieentwicklung, als auch für die Bestimmung der Gewichte eines kNN. NEAT hat sich als sehr gut, anpassungsfähig und relativ einfach in der Anwendung gezeigt. In diesem Beitrag wird NEAT in der Simulation angewendet, um ein kNN, das die Navigation des Roboters übernimmt, zu erhalten. Der Fokus liegt dabei auf der Erstellung der Fitnessfunktion und die Spezifikation und Durchführung einer realitätstreuen Simulation für den praktischen Einsatz. Die enge Verknüpfung von Realität und Simulationswelt hat entscheidend dazu beigetragen, dass der Umstieg aus der Simulation in die reale Welt ein Erfolg (höhere Anpassungsfähigkeit) wird. Dieser Artikel basiert auf der Diplomarbeit von [2].

Köpsel, T.; Noglik, A.; Pauli, J.

36

Messung der Infiltrationsgeschwindigkeit von Oberflächenwasser mit Hilfe des natürlichen Isotops Radon222  

Microsoft Academic Search

Kurzfassung  \\u000a \\u000a Das natürlich vorkommende Isotop Radon-222 kann wegen deutlicher Konzentrationsunterschiede in Grund- und Oberflächenwässern\\u000a als natürlicher Tracer zur Bestimmung der Aufenthaltszeiten von infiltriertem Oberflächenwasser und der Infiltrationsgeschwindigkeit\\u000a eingesetzt werden. Für das Untersuchungsgebiet in der Torgauer Elbaue wurde eine Korrelation zwischen der Radonaktivitätskonzentration\\u000a des Grundwassers und dem lithologischen Aufbau des Grundwasserleiters gefunden. Niedrige Radonaktivitätskonzentrationen im\\u000a Grundwasser in der Nähe eines Oberflächengewässers

Jörg Dehnert; Wolfgang Nestler; Klaus Freyer; Hanns-Christian Treutler

1999-01-01

37

The von Willebrand factor  

Microsoft Academic Search

Summary  Von Willebrand factor (vWf) is a multimeric and multivalent adhesive protein which is essential for platelet adhesion to subendothelium\\u000a and for stabilization of factor VIII procoagulant activity in circulation. The quantitative measurement of vWf involves essentially\\u000a two different approaches. The first is based on the interaction between vWf and Gp Ib of the platelet membrane in presence\\u000a of ristocetin (ristocetin

Francesco Rodeghiero; Giancarlo Castaman

1990-01-01

38

Von Willebrand Disease: An Overview  

PubMed Central

Most commonly inherited bleeding disorder, first described in Aland Islands by Erik von Willebrand. It occurs as a result of decrease in plasma levels or defect in von Willebrand factor which is a large multimeric glycoprotein. Monomers of this glycoprotein undergo N-glycosylation to form dimers which get arranged to give multimers. Binding with plasma proteins (especially factor VIII) is the main function of von Willebrand factor. The disease is of two forms: Inherited and acquired forms. Inherited forms are of three major types. They are type 1, type 2, and type 3; in which type 2 is sub-divided into 2A, 2B, 2M, 2N. Type 1 is more prevalent than all other types. Mucocutaneous bleeding is mild in type 1 whereas it is mild to moderate in types 2A, 2B, and 2M. Type 2N has similar symptoms of haemophilia. The pathophysiology of each type depends on the qualitative or quantitative defects in von Willebrand factor. The diagnosis is based on von Willebrand factor antigen, von Willebrand factor activity assay, FVIII coagulant activity and some other additional tests. Results should be analyzed within the context of blood group. von Willebrand factor multimer analysis is essential for typing and sub typing the disease. The management of the disease involves replacement therapy, non-replacement therapy and other therapies that include antifibrinolytics and topical agents.

Bharati, K. Pavani; Prashanth, U. Ram

2011-01-01

39

Bestimmung des Wirkstoffes Fenoxycarb in Holz mittels Hochdruckflüssigchromatographie  

Microsoft Academic Search

Zusammenfassung  Fenoxycarb ist ein insektizider Wirkstoff, der wegen seiner hormonähnlichen Wirkung in sehr geringen Konzentrationen in Holzschutzmitteln\\u000a eingesetzt werden kann. Das hat zur Folge, dass aus Extrakten von behandeltem Holz relativ geringe Fenoxycarb-Mengen vor dem\\u000a Hintergrund ebenfalls extrahierter Holzinhaltsstoffe zu bestimmen sind. In Vergleichsanalysen verschiedener Laboratorien wurde\\u000a gezeigt, dass Fenoxycarb durch Methanol mit hoher Ausbeute aus Holz extrahierbar ist und in

Ute Schoknecht; Claudia Bornkessel; Christina Fürhapper; Jan Gunschera; Helmut Härtner; Rainer Hill; Jan Kochan; Eckhard Melcher; Ursula Wilken; Joachim Wittenzellner; Matthias Wobst

2010-01-01

40

von Willebrand Disease  

PubMed Central

von Willebrand disease (VWD) is a common inherited bleeding disorder characterized by excessive mucocutaneous bleeding. Characteristic bleeding symptoms include epistaxis, easy bruising, oral cavity bleeding, menorrhagia, bleeding after dental extraction, surgery and/or childbirth and in severe cases, bleeding into joints and soft tissues. There are three subtypes: types 1 and 3 represent quantitative variants and type 2 is a group of four qualitative variants: 1) type 2A - characterized by defective von Willebrand factor (VWF) -dependent platelet adhesion because of decreased high molecular weight (HMW) VWF multimers, 2) type 2B - caused by pathologically increased VWF-platelet interactions, 3) type 2M - caused by decreased VWF-platelet interactions not based on the loss of HMW multimers and 4) type 2N - characterized by abnormal binding of VWF to FVIII. The diagnosis of VWD requires specialized assays of von Willebrand factor (VWF) and/or molecular genetic testing of VWF. Severe bleeding episodes can be prevented or controlled with intravenous infusions of virally-inactivated plasma-derived clotting factor concentrates containing both VWF and FVIII. Depending on the VWD type, mild bleeding episodes usually respond to intravenous or subcutaneous treatment with desmopressin, a vasopressin analog. Other treatments that can reduce symptoms include fibrinolytic inhibitors and hormones for menorrhagia.

Goodeve, Anne C.

2013-01-01

41

Quantitative Analyse von Korallengemeinschaften des Sanganeb-Atolls (mittleres Rotes Meer). II. Vergleich mit einem Riffareal bei Aqaba (nördliches Rotes Meer) am Nordrande des indopazifischen Riffgürtels  

Microsoft Academic Search

Quantitative studies of coral communities in the central and northern Red Sea were designed for comparison of the community structure in both areas. The central Red Sea provides reef-building Scleractinia and reef-inhabiting Alcyonaria with optimal temperature conditions, whereas the north tip of the Gulf of Aqaba (29°30? N) represents the northernmost outpost of coral reefs in the Indian Ocean. It

H. Schuhmacher; H. Mergner

1985-01-01

42

Dr. Wernher Von Braun  

NASA Technical Reports Server (NTRS)

Dr. Wernher von Braun with Dr. Eberhard Rees and R.W. Cook at a press conference concerning Dr. Von Braun's assignment to NASA headquarters and Dr. Rees' subsequent assignment as Marshall Center director.

1999-01-01

43

Quantitative Analyse von Korallengemeinschaften des Sanganeb-Atolls (mittleres Rotes Meer). II. Vergleich mit einem Riffareal bei Aqaba (nördliches Rotes Meer) am Nordrande des indopazifischen Riffgürtels  

NASA Astrophysics Data System (ADS)

Quantitative studies of coral communities in the central and northern Red Sea were designed for comparison of the community structure in both areas. The central Red Sea provides reef-building Scleractinia and reef-inhabiting Alcyonaria with optimal temperature conditions, whereas the north tip of the Gulf of Aqaba (29°30' N) represents the northernmost outpost of coral reefs in the Indian Ocean. It is generally assumed that coral diversity decreases towards the margins of the global reef-belt. In the Red Sea, generic diversity of hermatypic Scleractinia slightly decreases from the central to the northern part (51 : 48 genera); but cnidarian species abundance (species number per 25 m2 area) was found to increase from 62 to 98 species and the Shannon-Wiener diversity index increased from 2.58 to 3.67 with regard to colony number. The mean colony size was 189 cm2 at Sanganeb-Atoll, but only 52 cm2 at Aqaba. The mean numbers of colonies were inversely related: 662 per 25 m2 at Sanganeb-Atoll and 2028 at Aqaba. Uninhabited parts of the studied areas amounted to 47 % at Sanganeb-Atoll and to 56 % at Aqaba. The community structure of the studied areas indicates that occasional perturbations prevent the progress of the community towards a low-diversity equilibrium state. Since severe hydrodynamic damage is extremely rare in 10 m depth, major disturbances may occur by sedimentation, by the interference of grazers (e. g. Diadema setosum) and due to overgrowth by space-competitors (mainly soft corals). These events are to be regarded as throwbacks in the process of monopolization of the area by well adapted species. Recovery from such perturbations (i.e. recolonization of dead areas) obviously takes place at different velocities in the northern and central Red Sea, for the mean water temperature at Aqaba is 5 °C lower than in the central Red Sea. Hence the process of taking over a given space by a few species proceeds further in the central Red Sea than at its northern end. The increase in diversity per area towards high latitudes is comparable to that with depth. It is concluded from the great number of species at Aqaba that these reefs mark the northernmost outpost of the Indian Ocean only geographically but not ecophysiologically; they would occur at even higher latitudes, if the Gulf of Aqaba extended farther north.

Schuhmacher, H.; Mergner, H.

1985-12-01

44

Determination of Cu, Mn, Zn in Chromatin of Lymphocytes from Patients with Multiple Warts (Bestimmung von Cu, Mn, Zn in Chromatin aus Lymphozyten von Patienten mit Multiplen Warzen).  

National Technical Information Service (NTIS)

Previous investigations have shown that after virus infection the trace elements associated with a nucleic acid fraction was changed. Especially the transition elements Cu, Mn, Zn can interfere with the regulation of DNA-metabolism. Chromatin-bound metal ...

D. Teherani H. Altmann A. Topaloglou J. Soeltz-Szoets B. Syre

1981-01-01

45

[Type 2N von Willebrand disease (Normandy)].  

PubMed

Willebrand disease is the most common constitutional abnormality of hemostasis. It reflects a qualitative or quantitative abnormality of von Willebrand factor (vWF) responsible for hemorrhagic syndrome, mainly mucosal, of variable expression. Type 2N (Normandy) is a rare form of von Willebrand disease due to a qualitative abnormality of vWF that disrupts its ability to bind to factor VIII. The disease biologically combines APTT prolongation, a lower level of factor VIII, and a normal or subnormal rate of vWF, which may suggest a mild form of hemophilia A. This confusion can lead not only to a misdiagnosis but also to inappropriate treatment. PMID:21130625

Monpoux, F; Brunet, P; Fischer, F; Appert-Flory, A

2011-01-01

46

Lernen von und bei Max von Laue  

NASA Astrophysics Data System (ADS)

Erinnerungen an die Entstehungsgeschichte und die Frühzeiten der Röntgenstrukturanalyse.Translated AbstractLearning at Max von LaueRemembrances of the historical rise and the early times of X-ray structure analysis.

Thiessen, P. A.

47

Multimodale Therapie von Fettstoffwechselstörungen  

Microsoft Academic Search

Zusammenfassung  Nicht nur ein erhöhtes LDL-Cholesterin, sondern auch ein niedriges HDL-Cholesterin und hohe Triglyzeride korrelieren im multifaktoriellen\\u000a Prozess der Atherombildung eng mit dem Auftreten von kardiovaskulären Ereignissen. Verschiedene Studien haben eine hohe Prävalenz\\u000a von Fettstoffwechselstörungen sowie des metabolischen Syndroms in Deutschland gezeigt. Als erster medikamentöser Therapieansatz\\u000a zur Behandlung einer Fettstoffwechselstörung gilt nach wie vor die Verordnung von Statinen. Allerdings verbleibt trotz

Annett Stahn; Markolf Hanefeld

2011-01-01

48

Acquired von Willebrand Disease  

Microsoft Academic Search

Acquired von Willebrand disease (AvWD) is a rare complication of an autoimmune or neoplastic disease. It is associated mostly with a lymphoid or plasma cell proliferative disorder. The clinical manifestations are similar to congenital von Willebrand disease. Diagnosis is confirmed by the demonstration of decreased levels of factor VIII coagulant activity (VIII:C), ristocetin cofactor activity (vWF:RCo), and von Willebrand factor

Ayalew Tefferi; William L Nichols

1997-01-01

49

Theodore von Karman  

NASA Technical Reports Server (NTRS)

Theodore von Karman. NACA: In the eyes of most aeronautical experts, the overall record of Max Munk in aerodynamic research falls short of that achieved by fellow immigrant Theodore von Karman (the short man in the double breasted coat in the middle), shown here visiting Langley in December 1926. People in the photo include Max Munk, aerodynamic researcher; Theodore von Karman; George Lewis, director of research; Henry Reid, engineer in charge; Fred Weick, PRT head; Paul Hemke; Elliott Reid, future Stanford University Professor.

1926-01-01

50

Dr. Wernher von Braun  

NASA Technical Reports Server (NTRS)

Dr. Wernher von Braun served as Marshall Space Flight Center's first director from July 1, 1960 until January 27, 1970, when he was appointed NASA Deputy Associate Administrator for Plarning. Following World War II, Dr. von Braun and his German colleagues arrived in the United States under Project Paperclip to continue their rocket development work. In 1950, von Braun and his rocket team were transferred from Ft. Bliss, Texas to Huntsville, Alabama to work for the Army's rocket program at Redstone Arsenal and later, NASA's Marshall Space Flight Center. Under von Braun's leadership, Marshall developed the Saturn V launch vehicle which took Apollo astronauts to the moon.

1960-01-01

51

Titanisierung von Implantatoberflächen  

NASA Astrophysics Data System (ADS)

Titan gilt seit Jahrzehnten als einer der wichtigsten Implantatwerkstoffe in der Medizin. Neben den guten mechanischen Eigenschaften (Leichtigkeit, hohe Festigkeit etc.), besitzen Titanimplantate vor allem eine hervorragende Körperverträglichkeit, so dass die Implantate optimal in den humanen Organismus integriert werden [1]. Ist jedoch aufgrund der Anforderungen an das Implantat eine hohe Flexibilität und/ oder Elastizität gefragt, so scheidet der Werkstoff Titan aufgrund seiner spröden und unflexiblen Materialeigenschaften aus. Die Folge ist der Einsatz von Implantatmaterialien, sowohl künstlichen als auch biologischen Ursprungs, welche nicht selten eine unzureichende Biokompatibilität aufweisen und somit zu Fremdköper- und immunologischen Reaktionen und Einkapselung des Implantates führen können. Die Erhöhung der Körperverträglichkeit, eine Adaption an das biologische Umfeld und eine hohe Biokompatibilität sind demzufolge die wichtigsten Eigenschaften bei der bedarfsgerechten Herstellung von Implantaten und Implantatoberflächen. Zur Gestaltung von innovativen, biokompatiblen Oberflächen stehen unterschiedliche technische Lösungsansätze zur Verfügung. Zum einen besteht die Möglichkeit, geeignete Oberflächeneigenschaften aus dem Grundmaterial selbst zu optimieren. Dies geschieht unter anderem durch Modifikation der Werkstoffoberflächen in Form von Texturierungen und Oberflächenrauhigkeiten. Zum anderen können die Oberflächeneigenschaften unabhängig von denen des Trägermaterials gestaltet werden. Durch Funktionalisierung der Oberflächen mit geeigneten Beschichtungen oder der Zugabe von Medikamenten (Drug Eluting) werden die Kunststoffimplantate dahingehend verändert, dass eine Steigerung der Körperakzeptanz erreicht wird. Die Titanbeschichtung von Implantatoberflächen kombiniert die positiven Materialeigenschaften von Titan und Polymer.

Zimmermann, Hanngörg; Heinlein, Markus; Guldner, Norbert W.

52

Manuelle Montage von Kleingeräten  

NASA Astrophysics Data System (ADS)

Wie das Wort "manuell“ (lat. manus: Hand; engl. manual: von Hand) besagt, werden bei der manuellen Montage die Montagevorgänge durch den Menschen ausgeführt. Hier steht der Mensch wie bei kaum einem anderen Fertigungsprozess im Mittelpunkt. Durch den Einsatz seiner Hände, seiner Fingerfertigkeit, seiner Sinnesorgane und seiner Intelligenz führt er unter Inanspruchnahme von Hilfsmitteln, wie Werkzeuge, Vorrichtungen und Lehren, die Montagevorgänge aus.

Lotter, Bruno

53

Dr. Wernher Von Braun  

NASA Technical Reports Server (NTRS)

Dr. Wernher Von Braun (left) and Fred W. Kelley examine a ST-100 Stellar Instrument Platform in the astrionics lab. Dr. Von Braun, then deputy associate administrator for planning, NASA, was visiting on the anniversary of the establishment of the Marshall Space Flight Center.

1999-01-01

54

Dr. Wernher von Braun  

NASA Technical Reports Server (NTRS)

Dr. von Braun is looking out from a 10th floor window of building 4200 at the Marshall Space Flight Center (MSFC). He was the first Center Director and served as the Director from July 1960 through February 1970. Following World War II, Dr. von Braun and his German colleagues arrived in the United States under the Project Paperclip (American acquisition of German rocket experts) to continue their rocket development work. In 1950, von Braun and his German Rocket Team (also called the Peenemuende Team) were transferred from Ft. Bliss, Texas to Huntsville, Alabama to work for the Army's rocket program at Redstone Arsenal and later, NASA's Marshall Space Flight Center (MSFC). Under Dr. von Braun's leadership, MSFC developed the Saturn V launch vehicle, which placed the first men, two American astronauts, on the Moon. Wernher von Braun's life was dedicated to expanding man's knowledge through the exploration of space.

2004-01-01

55

[Acquired von Willebrand's disease].  

PubMed

We describe a patient with acquired von Willebrand's disease and Waldenström's macroglobulinemia. He suffered from an acquired tendency to bleed. The laboratory findings were identical to those of congenital von Willebrand's disease. The acquired form of this bleeding disorder is seen in association with immunologically active B cell lymphomas, certain other malignant tumours, and autoimmune diseases. The incidence and prevalence are unknown, but this disorder is probably uncommon. We discuss possible pathogenetic mechanisms. Acquired von Willebrand's disease should be considered in patients with an acquired tendency to bleed, especially if the patient also has a lymphoproliferative, neoplastic, or autoimmune disease. PMID:8332973

Berentsen, S; Hammerstrøm, J

1993-05-10

56

Bewertung von Fahrzeuggeräuschen  

NASA Astrophysics Data System (ADS)

Bei der Wahrnehmung und Beurteilung eines Automobils sind unzählige Merkmale und Eigenschaften von Bedeutung. Dabei können Merkmale objektiv-technisch beschrieben werden, wie Angaben zur Motorisierung, Höchstgeschwindigkeit, Drehmoment, zulässige Zuladung, Verbrauch usw. Daneben sind weitere Eigenschaften von Bedeutung, die sich einer einfachen objektiv-technischen Beschreibung entziehen. Hier sind Begriffe zu nennen, wie Sicherheit, allgemeine Qualitätsanmutung, Design, Ergonomie, Komfort, Haptik, Fahrdynamik, Zuverlässigkeit, die deutlich schwieriger objektiv erfassbar und beschreibbar sind (Abb. 4.1).

Genuit, Klaus; Schulte-Fortkamp, Brigitte; Fiebig, André; Haverkamp, Michael

57

Dr. Wernher Von Braun  

NASA Technical Reports Server (NTRS)

Dr. Wernher Von Braun (right), Deputy Associate Administrator for planning, National Aeronautics and Space Administration, inspects the mockup of the Saturn Workshop during a visit marking the 10th anniversary of the Marshall Center. Shown with Dr. Von Braun, from left to right, are Karl Heimburg, Director of the astronautics lab; Herman K. Weidner, Director of Science and Engineering, and George Hardy of the Astronautics lab.

1999-01-01

58

Dr. Wernher Von Braun  

NASA Technical Reports Server (NTRS)

Dr. Wernher Von Braun (right), Deputy Associate Administrator for Planning, National Aeronautics and Space Administration, inspects the mockup of the Saturn Workshop during a visit marking the 10th anniversary of the Marshall Center. Shown with Dr. Von Braun, from left to right, are Karl Heimburg, Director of the Astronautics Lab; Herman K. Weidner, Director of Science and Engineering, and George Hardy of the Astronautics Lab.

1999-01-01

59

Dr. von Braun's Bust  

NASA Technical Reports Server (NTRS)

In a ceremony honoring Dr. Wernher von Braun, who served as Marshall Space Flight Center Director from 1960 to 1970, Marshall officials renamed the 4200 Building Complex as the Wernher von Braun Office Complex and unveiled a bust of the former director. This photograph is a close-up of the bust in the courtyard. The sculptor of the bust is a MSFC employee, Jack Hood.

1994-01-01

60

The Molecular Genetics of von Willebrand Disease  

PubMed Central

Quantitative and/or qualitative deficiency of von Willebrand factor (vWF) is associated with the most common inherited bleeding disease von Willebrand disease (vWD). vWD is a complex disease with clinical and genetic heterogeneity. Incomplete penetrance and variable expression due to genetic and environmental factors contribute to its complexity. vWD also has a complex molecular pathogenesis. Some vWF gene mutations are associated with the affected vWF biosynthesis and multimerization, whereas others are associated with increased clearance and functional impairment. Moreover, in addition to a particular mutation, type O blood may result in the more severe phenotype. The present review aimed to provide a summary of the current literature on the molecular genetics of vWD. Conflict of interest:None declared.

Berber, Ergul

2012-01-01

61

Bestimmung des notwendigen Nmin?Angebots für brokkoli (brassica oleracea var: Italica) durch zerstörungsfreie messung des wachstumsverlaufs  

Microsoft Academic Search

Für Brokkoli wird zum Kulturbeginn ein Nmin?Angebot von mehr als 100 kg N\\/ha empfohlen, obwohl die N?Aufnahme bis zum 20. Kulturtag nur etwa 20 kg N\\/ha beträgt. Mit Hilfe der Gamma?Scanning?Technik wurde die Wirkung eines variierten Nmin?Ange?bots auf das Wachstum zerstörungsfrei gemessen.Zur Pflanzung wurde eine N?Düngung von 50, 100 bzw. 150 kg N\\/ha und zum Zeitpunkt beginnender Wachstumsminderung Kopfdüngungen von

Bodo Gutezeit

1998-01-01

62

Renaturierung von Waldökosystemen  

NASA Astrophysics Data System (ADS)

Wälder sind neben der Landwirtschaft und den urban-industriellen Siedlungsflächen flächenmäßig die Hauptnutzungstypen in Mitteleuropa und stellen heute multifunktionale ökosysteme dar. Zusätzlich zur Holzproduktion kommt ihnen eine Regulations-(z.B.Wasserhaushalt), Schutz (z.B. von Biodiversität und gegen Erosion, Lawinen, Immissionen und Lärm) und Erholungsfunktion zu. Zudem haben Wälder als Kohlenstoffsenken auch eine besondere Bedeutung für den Klimaschutz.

Zerbe, Stefan

63

Hilbert von Neumann modules  

Microsoft Academic Search

We introduce a way of regarding Hilbert von Neumann modules as spaces of operators between Hilbert space, not unlike [Skei], but in an apparently much simpler manner and involving far less machinery. We verify that our definition is equivalent to that of [Skei], by verifying the `Riesz lemma' or what is called `self-duality' in [Skei]. An advantage with our approach

Panchugopal Bikram; Kunal Mukherjee; R. Srinivasan; V. S. Sunder

2011-01-01

64

Dr. Wernher Von Braun  

NASA Technical Reports Server (NTRS)

Shown viewing the Apollo telescope mockup are, from left to right, Charles Donlan, deputy associate administrator for manned space flight; Dr. Wernher Von Braun, Marshall Space Flight Center director; William Horton, astrionics lab; Dr. Thomas Paine, NASA deputy administrator; Warner Kuers, director of the ME lab.

1999-01-01

65

Dr. Wernher Von Braun  

NASA Technical Reports Server (NTRS)

Marshall Space Flight Center director Wernher Von Braun and his family were honored with a series of events prior to his relocation to Washington, D.C. where he was assigned duties at NASA headquarters as deputy associate administrator for planning. Here he is shown with General Richard Drury and Hazel Toftoy, widow of General H.N. Toftoy.

1999-01-01

66

Dr. Wernher Von Braun  

NASA Technical Reports Server (NTRS)

A camerman catches Dr. Wernher Von Braun, Director of the Marshall Space Flight Center, his son, Peter, and daughter, Martgrit, as they arrive at the employee picnic held to celebrate man's first landing on the moon 6 days earlier. In the foreground is David R. Newby, Director of Administration and Technical Services at the Marshall Space Flight Center.

1999-01-01

67

Von Braun Fountain  

NASA Technical Reports Server (NTRS)

A fountain representing a rocket launch was dedicated in the Von Braun courtyard outside of Building 4200 at Marshall Space Flight Center during the weekend celebrating the 30th arniversary of the Apollo 11 lunar landing. On hand for the festivities were many of the Saturn and Apollo astronauts.

1999-01-01

68

Chemischer Nachweis und Ausscheidung von Vitamin B 1 im Harn  

Microsoft Academic Search

Zusammenfassung  Es wurde eine quantitative chemische Bestimmungsmethode von Vitamin B1 im Harn ausgearbeitet. Mit Tonerdeadsorbaten oder anderen Eluaten wurden chemische Reaktionen nachKinnersly undPeters und nachJansen angestellt. Erstere l??t sich auf Tonerdeadsorbate aus Harn nicht anwenden. Auch die Thiochrom-Reaktion in der Modifikation\\u000a vonJansen wird durch andere Harnbestandteile gest?rt, besonders durch Harnfarbstoffe, Urochrom, die reduzierend wirken. Erst nach Herstellung\\u000a besonders gereinigter Tonerdeadsorbate durch

F. Widenbauer; O. Huhn; G. Becker

1937-01-01

69

A Reliable von Willebrand Factor: Ristocetin Cofactor Enzyme-Linked Immunosorbent Assay to Differentiate between Type 1 and Type 2 von Willebrand Disease  

Microsoft Academic Search

von Willebrand disease (vWD) is the most common hereditary bleeding disor- der due to either a qualitative or a quantitative defect in von Willebrand factor (vWF). vWF is a multimeric plasma protein that plays an important role in (1) primary hemosta- sis, by sustaining indirect platelet adhesion especially at high shear rates, and in (2) sec- ondary hemostasis, by protecting

Karen Vanhoorelbeke; Nancy Cauwenberghs; Griet Vandecasteele; Stephan Vauterin; Hans Deckmyn

2002-01-01

70

Dr. von Braun at 'Wernher von Braun Day' Celebration  

NASA Technical Reports Server (NTRS)

In 1970 Marshall Space Flight Center (MSFC) Director Dr. Wernher von Braun (right) was reassigned to NASA Headquarters to serve as Deputy Associate Administrator for Plarning. Prior to his transfer, Dr. von Braun was honored for his career in Huntsville, Alabama, with the celebration of 'Wernher von Braun Day.' Among those participating were Alabama Governor Albert Brewer (left) and Alabama Senator John Sparkman (center). (Courtesy of Huntsville/Madison County Public library)

1970-01-01

71

Biotransformation von ausgewählten Gyrasehemmern  

Microsoft Academic Search

Zusammenfassung Die Gyrasehemmer Norfloxacin, Ciprofloxacin, Pefloxacin und Ofloxacin haben als gemeinsame Grundstruktur das 3-Carboxy-4-oxo-6-fluor-7-(1-piperazinyl)-1,4-dihydrochinolin. Sie durchlaufen verschiedene Biotransformationen, die an Tieren und teilweise auch beim Menschen beschrieben worden sind: 1. Konjugation der Carboxylgruppe mit Glukuronsäure. (Die Bildung des O-Methylesters von Norfloxacin ist nur bei der Ratte gefunden worden). 2. Oxidation des Piperazin-Ringes zur 3-Oxo-Verbindung und Abbau (oder Zerfall) des Piperazin-Ringes

K. Borner; H. Lode

1986-01-01

72

Kathodolumineszenztypisierung rezenter quarzsande von wangerooge  

Microsoft Academic Search

Kurzfassung  Die Kombination von Kathodolumineszenz (KL)-Mikroskopie und Bildanalyse hochauflösender digitaler Mikrofotographie ermöglicht\\u000a eine genaue Erfassung der initialen KL-Farben von Quarzen und deren Veränderung im Verlauf zunehmenden Elektronenbeschusses.\\u000a Mit dieser RGB-Methodik (rotgrün-blau) kann die häufig verbreitete genetische Vielfalt von Quarzkörnern siliziklastischer\\u000a Ablagerungen erfasst und typisiert werden.\\u000a \\u000a Für rezente Quarzsande von Ostwangerooge lassen sich 16 Quarz-KL-Typen unterscheiden, deren Anteile auf ein vornehmlich plutonisches

Thomas Götte; Detlev K. Richter

2005-01-01

73

Bestimmung von Absorptionsquerschnitten und Quantenausbeuten verschiedener photoaktiver troposphaerischer Spurengase. (Measurement of absorption cross sections and quantum yields of various photoactive tropospheric trace gases).  

National Technical Information Service (NTIS)

Photolytic parameters of a number of photoactive carbonyl compounds were determined: Methylethyl ketone CH(sub 3)COC(sub 2)H(sub 5) (MEK) from butane photooxidation; methylvinyl ketone CH(sub 2)=CHCOCH(sub 3) (MVK), methacrolein CH(sub 2)=C(CH(sub 3))CHO ...

G. K. Moortgat R. Meller W. Raber K. Reinholdt

1992-01-01

74

Bestimmung von Zn, Cu und Mn im Chromatin aus Bovinen Milch- und Blutlymphozyten (Determination of Zn, Cu and Mn in Chromatine of Bovine Milk- and Blood-Lymphocytes).  

National Technical Information Service (NTIS)

It has been shown in several investigations that chronic diseases and virus or bacterial infections may cause heavy changes in the content of trace metals, especially zinc, copper and manganese, in chromatine of cells. The mentioned trace metals were now ...

M. A. Assadian D. K. Teherani H. Altmann W. Binder

1982-01-01

75

Bestimmung von leichtfluechtigen organischen Komponenten mit Hilfe der Thermodesorptions-Cold-Trap(TCT)-Injektionsmethode. (Measurement of volatile organic components using the thermodesorption cold trap (TCT) injection technique).  

National Technical Information Service (NTIS)

High-resolution gas chromatography is a common technique for analyzing volatile constituents of complex samples. Preconcentration of the samples is usually necessary as the volumes that may be injected into a capillary gas chromatography system are limite...

H. Kiess A. Hartung

1989-01-01

76

Nichtwässrige derivative Headspace Festphasenmikroextraktion in Verbin- dung mit GC-MS in der Haaranalyse - eine sensitive Methode zur Bestimmung von Cannabis und Alkoholmissbrauch  

Microsoft Academic Search

Objective: In general, headspace solid phase microextraction (HS-SPME) as a method of sample preparation of hair for drugs is performed from aqueous hair hydrolysates or hair extracts. Therefore, the method is limited to an extraction temperature below the boiling point of the aqueous phase (100-120 °C, depending on the salt content) and cannot be combined with in- sample derivatization by

Johannes Schräder; Thomas Nadulski; Fritz Pragst

77

The use of an algorithm for the laboratory diagnosis of von Willebrand disease  

Microsoft Academic Search

Von Willebrand Disease (vWD) is a bleeding disorder caused by either quantitative (type 1 and 3) or qualitative (type 2) defects of von Willebrand factor (vWF). No single test is available that provides appropriate information about the various functions of vWF and the laboratory diagnosis of vWD is based on a panel of tests that includes the measurement of factor

MURIEL MEIRING; PHILIP N BADENHORST; MARELI KELDERMAN

78

VON THÜNEN AND URBAN SPRAWL  

Microsoft Academic Search

In explaining agricultural patterns near urban areas, Von Thünen's theory is generally applicable where the primary force determining the pattern is transport cost to the market. When this is the case, the pattern of agricultural land use is one of decreasing intensity with distance from the city. Von Thünen's theory still applies in underdeveloped parts of the world, but his

ROBERT SINCLAIR

1967-01-01

79

Die hypopeltaten Brakteen von Peperomia  

Microsoft Academic Search

Zusammenfassung Die Ontogenese der schildförmigen Brakteen vonPeperomia zeigt eindeutig, daß der Aufbau der Schildfläche durch das Wachstum normaler Blattränder allein durchgeführt wird, also in der gleichen Weise wie bei den epipeltaten Schildblättern. Nur besteht gegenüber diesen der Unterschied, daß der Zusammenschluß der Spreitenränder dorsal über der Ansatzstelle des Blattstieles vorsichgeht. Der Blattstiel zeigt sich von Anfang an als unifazial, und

Walter Leinfellner

1953-01-01

80

Extraktion von DNA  

NASA Astrophysics Data System (ADS)

Eine DNA-gestützte Analytik spielt im Lebensmittelbereich eine große Rolle. So wird die PCR bzw. die Real Time PCR z. B. für den Nachweis von Krankheitserreger in Lebensmitteln, zur Tier- und Pflanzenartendifferenzierung und den Nachweis von gentechnologisch veränderten Organismen eingesetzt [1]. Grundvoraussetzung für die sehr sensitiven molekularbiologischen Methoden ist eine saubere und kontaminationsfreie Nukleinsäure [2]. Die Qualität der Nukleinsäure entscheidet über Erfolg und Misserfolg der anschließenden molekularbiologischen Analytik. Deshalb werden im Bereich der Lebensmittelanalytik hohe Anforderungen an das jeweilige DNA-Extraktionsprotokoll gestellt. Durch die Anwendung eines geeigneten Extraktionsverfahrens soll die nachzuweisende DNA möglichst in hochmolekularer Form und frei von die nachfolgende Analytik hemmenden Substanzen vorliegen [1]. Gerade hier stellt die Natur der Lebensmittelmatrix eine besondere Herausforderung dar. Matrixkomponenten wie Fette, Zucker, Proteine und sekundäre Inhaltsstoffe erschweren die DNA-Extraktion und können, wenn sie nicht durch die Extraktion vollständig entfernt werden, zu einer Inhibierung der PCR führen [3]. Des Weiteren müssen auf der Matrixoberfläche vorhandene DNA-abbauende Enzyme gehemmt werden [1]. Daneben spielt der Einfluss verschiedener chemischer und physikalischer Parameter (pH-Wert, Temperatur, Enzyme, Scherkräfte) bei der Lebensmittelproduktion eine große Rolle für die Qualität der extrahierten DNA. So führen z. B. hohe Temperaturen und saure pH-Werte während der Lebensmittelverarbeitung zu einer Fragmentierung der DNA. Auch die physikalischen und chemischen Bedingungen der verwendeten Extraktionsmethode beeinflussen die Qualität der DNA [2]. Bleiben nach der Extraktion organische Lösungsmittel (Phenol, Ethanol), Enzyme, Proteine oder Salze zurück, können diese ebenfalls eine nachfolgende PCR inhibieren. Um eine Inhibition der PCR auszuschließen, sollten in der nachfolgenden Analytik entsprechende Inhibitionskontrollen mitgeführt werden [3].

Pöpping, Bert; Unterberger, Claudia

81

von Willebrand Factor  

Microsoft Academic Search

von Willebrand factor (vWF) from normal human plasma was purified and separated into three fractions containing high, medium, and low molecular weight vWF multimers. vWF fractions were tested for (1) vWF-antigen (vWF:Ag); (2) vWF-ristocetin cofactor activity (vWF:RiCof); (3) vWF-collagen binding activity (vWF:CBA); and (4) a monoclonal antibody-binding ELISA (mAB-binding ELISA), based on the vWF binding to immobilized monoclonal antibody directed

Bernhard E Fischer; Kathy B Thomas; Friedrich Dorner

1998-01-01

82

Dr. Wernher Von Braun  

NASA Technical Reports Server (NTRS)

Dr. Thomas Paine, Deputy Administrator of the National Aeronautics and Space Administration, examines an ordinary man's shoe outfitted for use in the Saturn I workshop. Pictured from the left in the Saturn I workshop mockup are William Brooksbank, propulsion and vehicle engineering laboratory; Dr. Paine; Dr. Wernher Von Braun, Marshall Center director; Colonel Clare F. Farley, Executive Officer in the Office Of The Administrator; and Charles J. Donlan, Deputy Associate Administrator for Manned Space Flight, Technical. the shoe Dr. Paine is holding has a unique fastener built into the sole to allow an astronaut to move about on the workshop floor and to remain in one position if he desires.

1999-01-01

83

Sulfation of von Willebrand factor  

SciTech Connect

von Willebrand factor (vWF) is a multimeric adhesive glycoprotein essential for normal hemostasis. We have discovered that cultured human umbilical vein endothelial cells incorporate inorganic sulfate into vWF. Following immunoisolation and analysis by polyacrylamide or agarose gel electrophoresis, metabolically labeled vWF was found to have incorporated (35S)-sulfate into all secreted multimer species. The time course of incorporation shows that sulfation occurs late in the biosynthesis of vWF, near the point at which multimerization occurs. Quantitative analysis suggests the presence, on average, of one molecule of sulfate per mature vWF subunit. Virtually all the detectable sulfate is released from the mature vWF subunit by treatment with endoglycosidases that remove asparagine-linked carbohydrates. Sulfated carbohydrate was localized first to the N-terminal half of the mature subunit (amino acids 1 through 1,365) by partial proteolytic digestion with protease V8; and subsequently to a smaller fragment within this region (amino acids 273 through 511) by sequential digestions with protease V8 and trypsin. Thus, the carbohydrate at asparagine 384 and/or 468 appears to be the site of sulfate modification. Sodium chlorate, an inhibitor of adenosine triphosphate-sulfurylase, blocks sulfation of vWF without affecting either the ability of vWF to assemble into high molecular weight multimers or the ability of vWF multimers to enter Weible-Palade bodies. The stability of vWF multimers in the presence of an endothelial cell monolayer also was unaffected by the sulfation state. Additionally, we have found that the cleaved propeptide of vWF is sulfated on asparagine-linked carbohydrate.

Carew, J.A.; Browning, P.J.; Lynch, D.C. (Harvard Medical School, Boston, MA (USA))

1990-12-15

84

Rethinking the diagnosis of von Willebrand disease.  

PubMed

von Willebrand disease (VWD) is the most common inherited bleeding disorder and arises from deficiencies and/or defects in the plasma protein von Willebrand factor (VWF). VWD is classified into 6 different types, with type 1 identified as a (partial) quantitative deficiency of VWF, type 3 defined by a (virtual) total deficiency of VWF, and type 2 identifying four separate types (2A, 2B, 2M, 2N) characterised by qualitative defects. The classification is based on phenotypic assays including FVIII, VWF:Ag and VWF activity, typically by ristocetin cofactor (VWF:RCo), but also increasingly by collagen binding (VWF:CB). Phenotypic testing may be supplemented by multimer analysis, RIPA, and VWF:FVIII binding. Although genetic analysis is not required to diagnose VWD or to define a classification type, it may be useful in discrete situations. The current review briefly covers this diagnostic process, with a focus on newer approaches, including extended test panels and the use of data from desmopressin challenges as a diagnostic tool. PMID:21193108

Favaloro, Emmanuel J

2011-01-01

85

On the Versatility of von Willebrand Factor  

PubMed Central

Von Willebrand factor (VWF) is a large multimeric protein, the function of which has been demonstrated to be pivotal to the haemostatic system. Indeed, quantitative and/or qualitative abnormalities of VWF are associated with the bleeding disorder Von Willebrand disease (VWD). Moreover, increased plasma concentrations of VWF have been linked to an increased risk for thrombotic complications. In the previous decades, many studies have contributed to our understanding of how VWF is connected to the haemostatic system, particularly with regard to structure-function relationships. Interactive sites for important ligands of VWF (such as factor VIII, collagen, glycoprotein Ib?, integrin ?IIb?3 and protease ADAMTS13) have been identified, and mutagenesis studies have confirmed the physiological relevance of the interactions between VWF and these ligands. However, we have also become aware that VWF has a more versatile character than previously thought, given its potential role in various non-hemostatic processes, like intimal thickening, tumor cell apoptosis and inflammatory processes. In the presence review, a summary of our knowledge on VWF structure-function relationships is provided in the context of the “classical” haemostatic task of VWF and in perspective of pathological processes beyond haemostasis.

Rauch, Antoine; Wohner, Nikolett; Christophe, Olivier D.; Denis, Cecile V.; Susen, Sophie; Lenting, Peter J.

2013-01-01

86

Dr. Wernher Von Braun  

NASA Technical Reports Server (NTRS)

On September 8, 1960 President Dwight D. Eisenhower visited Huntsville, Alabama to dedicate a new NASA field center in honor of General George C. Marshall, Eisenhower's wartime colleague and the founder of the famous Marshall Plan for European recover after World War II. The new George C. Marshall Space Flight Center was placed under the control of Dr. Wernher Von Braun shown here talking with President Eisenhower. As parto f his remarks dedicating the center, President Eisenhowe refereed to General Marshall as a 'man of yar, yet a builder of peace'. the Marshall Center's first major assignment including building the huge Saturn V rocket that launched human beings on their first journey to the surface of the moon in 1969.

1960-01-01

87

von Braun and German Publisher  

NASA Technical Reports Server (NTRS)

In this photograph, Guenter Ogger of Capitol Magazine, West Germany, greets Marshall Space Flight Center Director, Dr. Wernher von Braun. Mr. Ogger interviewed the famous rocket scientist for his magazine.

1969-01-01

88

Von Neumann-Morgenstern Solutions.  

National Technical Information Service (NTIS)

This paper gives a very short introduction to the von Neumann-Morgenstern theory of solutions, or stable sets, for multiperson cooperative games in characteristic function, or coalition, form. It includes the basic definitions which describes the essentia...

W. F. Lucas

1975-01-01

89

Expression of von Willebrand Factor  

Microsoft Academic Search

von Willebrand disease Normandy (vWD Normandy) is a recently described phenotype in which a mutant von Willebrand factor (vWF) appears structurally and functionally normal except that it does not bind to blood coagulation factor VIII. This interaction is required for normal survival of factor VIII in the circulation; consequently, vWD Normandy can present as apparent hemophilia A but with autosomal

Elodee A. Tuley; Christine Gaucher; Sylvie Jorieux; Neil K. Worrall; J. Evan Sadler; Claudine Mazurier

1991-01-01

90

Zebrafish von Willebrand Factor  

PubMed Central

von Willebrand factor (vWF) is a large protein involved in primary hemostasis. A dysfunction in this protein or an insufficient production of the protein leads to improper platelet adhesion/aggregation, resulting in a bleeding phenotype known as von Willebrand disease (vWD). To gain a better understanding of vWF interactions in vivo, the use of zebrafish as a model is ideal because of the transparency of the embryos and larvae. In this article, we examined the presence and function of vWF in hemostasis of zebrafish utilizing a variety of molecular methods. Using RT-PCR and antibody staining, we have shown that vWF mRNA is present in thrombocytes. Through antibody staining, we demonstrated vWF is synthesized in blood vessels. The role of zebrafish vWF in hemostasis was established through knockdown methods using vWF morpholino (vWF MO) antisense oligonucleotides. Embryos injected with vWF MO at the one to four cell stages resulted in a bleeding phenotype. Injection of embryos with vWF MO also caused an increase in time to occlusion within arteries in larvae upon laser induced injury. We then used vWF-specific Vivo-Morpholinos (VMO) to induce vWF knockdown in adult zebrafish by targeting the exon homologous to the human exon 28 of the vWF gene. The reduced ristocetin-mediated agglutination of thrombocytes in a plate tilting assay, using blood from adult zebrafish injected with VMO, provided evidence that vWF is involved in the hemostatic process. We also administered desmopressin acetate to larvae and adults which resulted in enhanced aggregation/agglutination of thrombocytes. Zebrafish genome database analysis revealed the presence of GPIb? gene. It also revealed the exon of zebrafish vWF gene corresponding to exon 28 of human vWF gen is highly similar to the exon 28 of human vWF gene, except that it has an insertion that leads to a translated peptide sequence that separates the two A domains coded by this exon. This exon is also conserved in other fishes. In summary, we established that zebrafish vWF has a role similar to that of vWF found in humans, thus, making zebrafish a useful model for studying the cell biology of vWF in vivo.

Carrillo, Maira; Kim, Seongcheol; Rajpurohit, Surendra Kumar; Kulkarni, Vrinda; Jagadeeswaran, Pudur

2010-01-01

91

Zebrafish von Willebrand factor.  

PubMed

von Willebrand factor (vWF) is a large protein involved in primary hemostasis. A dysfunction in this protein or an insufficient production of the protein leads to improper platelet adhesion/aggregation, resulting in a bleeding phenotype known as von Willebrand disease (vWD). To gain a better understanding of vWF interactions in vivo, the use of zebrafish as a model is ideal because of the transparency of the embryos and larvae. In this article, we examined the presence and function of vWF in hemostasis of zebrafish utilizing a variety of molecular methods. Using RT-PCR and antibody staining, we have shown that vWF mRNA is present in thrombocytes. Through antibody staining, we demonstrated vWF is synthesized in blood vessels. The role of zebrafish vWF in hemostasis was established through knockdown methods using vWF morpholino (vWF MO) antisense oligonucleotides. Embryos injected with vWF MO at the one to four cell stages resulted in a bleeding phenotype. Injection of embryos with vWF MO also caused an increase in time to occlusion within arteries in larvae upon laser induced injury. We then used vWF-specific Vivo-morpholinos (VMO) to induce vWF knockdown in adult zebrafish by targeting the exon homologous to the human exon 28 of the vWF gene. The reduced ristocetin-mediated agglutination of thrombocytes in a plate tilting assay, using blood from adult zebrafish injected with VMO, provided evidence that vWF is involved in the hemostatic process. We also administered desmopressin acetate to larvae and adults which resulted in enhanced aggregation/agglutination of thrombocytes. Zebrafish genome database analysis revealed the presence of GPIb? gene. It also revealed the exon of zebrafish vWF gene corresponding to exon 28 of human vWF gene is highly similar to the exon 28 of human vWF gene, except that it has an insertion that leads to a translated peptide sequence that separates the two A domains coded by this exon. This exon is also conserved in other fishes. In summary, we established that zebrafish vWF has a role similar to that of vWF found in humans, thus, making zebrafish a useful model for studying the cell biology of vWF in vivo. PMID:21035359

Carrillo, Maira; Kim, Seongcheol; Rajpurohit, Surendra Kumar; Kulkarni, Vrinda; Jagadeeswaran, Pudur

2010-12-15

92

Richard von Volkmann  

PubMed Central

Richard von Volkmann (1830–1889), one of the most important surgeons of the 19th century, is regarded as one of the fathers of orthopaedic surgery. He was a contemporary of Langenbeck, Esmarch, Lister, Billroth, Kocher, and Trendelenburg. He was head of the Department of Surgery at the University of Halle, Germany (1867–1889). His popularity attracted doctors and patients from all over the world. He was the lead physician for the German military during two wars. From this experience, he compared the mortality of civilian and war injuries and investigated the general poor hygienic conditions in civilian hospitals. This led him to introduce the “antiseptic technique” to Germany that was developed by Lister. His powers of observation and creativity led him to findings and achievements that to this day bear his name: Volkmann’s contracture and the Hueter-Volkmann law. Additionally, he was a gifted writer; he published not only scientific literature but also books of children’s fairy tales and poems under the pen name of Richard Leander, assuring him a permanent place in the world of literature as well as orthopaedics.

Willy, Christian; Schneider, Peter; Engelhardt, Michael; Hargens, Alan R.

2008-01-01

93

Quantitative radiography  

Microsoft Academic Search

We have developed a system of quantitative radiography in order to produce quantitative images displaying homogeneity of parts. The materials that we characterize are synthetic composites and may contain important subtle density variations not discernable by examining a raw film x-radiograph. In order to quantitatively interpret film radiographs, it is necessary to digitize, interpret, and display the images. Our integrated

C. M. Logan; J. M. Hernandez; G. J. Devine

1991-01-01

94

Experimental Determination of the Magnitudes of the Elemental Magnetic Domains of Nickel and Iron. Directional Coagulation of Aerosols II (1) (Experimentelle Bestimmung der GroeBe der magnetischen Elementargebiete von Nickel und Eisen. Gerichtete Koagulation von Aerosolen II (1)).  

National Technical Information Service (NTIS)

While the characteristics of dia- and paramagnetism can be explained almost completely from the magnetic properties of the single atoms, the characteristics evident with ferromagnetic materials (size, field dependent value of the permeability, appearance ...

D. Beischer A. Winkel

1978-01-01

95

Experimental Determination and Comparison with Theory of Thrust, Noise and Driving Weight of Propeller Drives Experimentelle Bestimmung und Vergleich Mit der Theorie von Schub, Laerm und Antriebsgewicht von Propellerantrieben.  

National Technical Information Service (NTIS)

Noise, static thrust, and thrust in flight were experimentally determined for the quiet aircraft, Sportavia S5. Results were compared with those from the calculation method of Hamilton Standard for propeller thrust and Pilatus for propeller noise. Prior c...

H. Oberdoerster M. Schliewa H. Schrecker M. Weck

1977-01-01

96

Role of Biotin in Monitoring the Toxicity of Chemicals to the Ames Tester Strains (Rolle von Biotin in der Bestimmung der Toxizitaet von Substanzen auf die Ames-Staemme).  

National Technical Information Service (NTIS)

The biotin requirement of a number of histidine-auxotrophic strains of Salmonella typhimurium, developed by Ames and his coworkers, was determined. In the literature, there is uninormity in the biotin requirements for the mutagenicity testing, but in the ...

A. L. Bhatia A. Wottawa

1981-01-01

97

Genetics Home Reference: Von Willebrand disease  

MedlinePLUS

... The VWF gene provides instructions for making a blood clotting protein called von Willebrand factor, which is essential for ... clots together and prevents the breakdown of other blood clotting proteins. If von Willebrand factor does not function normally ...

98

Über rektale Applikation von g-Strophanthin  

Microsoft Academic Search

Zusammenfassung g-Strophanthin wird bei rektaler Applikation von Katzen resorbiert und kann bereits in einer Menge von weniger als 1 mg tödlich wirken. Dennoch bleibt eine auffällige Spanne zwischen rektaler und intravenöser Wirkung bestehen.

W. Heubner; Berthold Fuchs

1933-01-01

99

The management of patients with congenital von Willebrand disease during surgery or other invasive procedures: focus on antihemophilic factor/von Willebrand factor complex  

PubMed Central

Von Willebrand disease, the most common hereditary bleeding disorder, arises from quantitative or qualitative defect of von Willebrand factor (VWF). The aim of the treatment is to correct the dual defect of hemostasis caused by the abnormal/reduced VWF and the concomitant deficiency of factor VIII (FVIII). The synthetic vasopressin analogue desmopressin is the mainstay of therapy in about 80% of patients, while nearly 20% are unresponsive and must be treated with FVIII/VWF concentrates. This latter therapeutic option will be focused in the review, with particular consideration to the management of surgery and invasive procedures in these patients.

Franchini, Massimo; Lippi, Giuseppe

2007-01-01

100

Entwurf von Schreibmaschinentastaturen mittels quadratischer Zuordnungsprobleme  

Microsoft Academic Search

Zusammenfassung Zur Ermittlung möglichst günstiger Schreibmaschinentastaturen wird ein quadratisches Zuordnungsproblem aufgestellt und suboptimal gelöst. Die dazu notwendigen sprachstatistischen Daten (Häufigkeit von Buchstaben und Buchstabenpaaren in verschiedenen Sprachen) wurden durch Auszählung von Texten von über 100.000 Buchstaben gewonnen. Es werden sowohl verbesserte Tastaturen für deutsche, englische, französische und niederländische Texte wie auch für gemischt-sprachliche Texte angegeben. Mit den vorgeschlagenen Methoden wurden

R. E. Burkard; J. Offermann

1977-01-01

101

[Von Hippel-Lindau syndrome].  

PubMed

Von Hippel-Lindau syndrome is an autosomal dominant inherited phacomatosis with a predisposition for the central nervous system and retina. There is variable expression with hemangioblastomas in the brain, medulla oblongata, spinal chord, renal carcinoma, pheochromocytoma, pancreatic cysts and islet cell tumors as well as tumors of the endolymphatic sac of the inner ear. Clinical symptoms occur first after an age of approximately 30 years. Magnetic resonance imaging (MRI) of the neuroaxis is indicated in all patients with a suspicion of von Hippel-Lindau syndrome. PMID:24292403

Reith, W; Körner, H

2013-12-01

102

Über die Herzglykosid-artige Wirkung von Progesteronbisguanylhydrazon (Progesteronbiguazon)  

Microsoft Academic Search

Die Wirkungen von Progesteronbisguanylhydrazon, g-Strophanthin und Digitoxigenin werden mit folgenden Methoden verglichen: Isolierte Vorhöfe von Meerschweinchen, Ratten, Kaninchen und jungen Katzen; Herz-Lungen-Präparat des Meerschweinchens; celluläre Membran- und Aktionspotentiale von Vorhofmuskulatur; Natrium- und Kalium-Bestimmungen und Messung des Calcium-Umsatzes in isolierten Vorhöfen von Meerschweinchen; isolierte Darmpräparate von Kaninchen und Meerschweinchen; Messung des Kalium-Gehaltes von „Kälteerythrocyten“ von Meerschweinchen, Kaninchen und Menschen. Ferner wird

A. Ehmer; K. Jahr; G. Kuschinsky; H. Lüllmann; H. Reuter; U. Wollert

1964-01-01

103

Quantitative analysis  

PubMed Central

Quantitative analysis permits the isolation of invariant relations in the study of behavior. The parameters of these relations can serve as higher-order dependent variables in more extensive analyses. These points are illustrated by reference to quantitative descriptions of performance maintained by concurrent schedules, multiple schedules, and signal-detection procedures. Such quantitative descriptions of empirical data may be derived from mathematical theories, which in turn can lead to novel empirical analyses so long as their terms refer to behavioral and environmental events. Thus, quantitative analysis is an integral aspect of the experimental analysis of behavior.

Nevin, John A.

1984-01-01

104

The von Karman swirling flows  

Microsoft Academic Search

Asymptotic boundary conditions are formulated for the von Karman swirling flows and families of two-point boundary value problems are solved using a sophisticated code which automatically adjusts the net and order of accuracy to yield efficient solutions. It is found that there are at least four distinct families of solutions, and results suggest that there might be an infinite number

Marianela Lentini; H. B. Keller

1980-01-01

105

Quantitative Easing  

Microsoft Academic Search

Central banks around the world have moved to cut interest rates to record lows, with many in advanced economies going further and embracing full quantitative easing – creating new money to inject into the economy. This paper examines why quantitative easing has been necessary, and whether it is likely to result in higher demand or instead show up in higher

Colin Ellis

2009-01-01

106

Quantitative NMR  

NSDL National Science Digital Library

This site features a learning module focused on principles and practice of NMR for quantitative analysis, an application less commonly associated with the technique than is structure determination. Links to simulation packages are included.

Korir, Albert K.; Larive, Cynthia K.

2011-07-18

107

On Quantitizing  

PubMed Central

Quantitizing, commonly understood to refer to the numerical translation, transformation, or conversion of qualitative data, has become a staple of mixed methods research. Typically glossed are the foundational assumptions, judgments, and compromises involved in converting disparate data sets into each other and whether such conversions advance inquiry. Among these assumptions are that qualitative and quantitative data constitute two kinds of data, that quantitizing constitutes a unidirectional process essentially different from qualitizing, and that counting is an unambiguous process. Among the judgments are deciding what and how to count. Among the compromises are balancing numerical precision with narrative complexity. The standpoints of “conditional complementarity,” “critical remediation,” and “analytic alternation” clarify the added value of converting qualitative data into quantitative form.

Sandelowski, Margarete; Voils, Corrine I.; Knafl, George

2009-01-01

108

Quantitative Research  

Microsoft Academic Search

\\u000a By means of the previously introduced Research Pyramid this chapter provides a concise overview of the quantitative research\\u000a approach. The essence of quantitative research is to use a ‘theory’ to frame and thus understand the problem at hand. Its\\u000a starting point if not focus can be to contribute to the development of theory. It is grounded in the basic attitude

Jan Jonker; Bartjan W. Pennink

109

Von Willebrand factor and platelet adhesiveness  

PubMed Central

A modification of Salzman's method has been used in an attempt to provide an assay in vitro for the von Willebrand factor. Platelet adhesiveness was increased in von Willebrand's disease by previously coating the beads with normal or haemophilic plasma or cryoprecipitate, whereas von Willebrand plasma had no corrective effect. Antihaemophilic factor (AHF) concentrates were studied in the same way and results compared with experiments in vivo.

Meyer, Dominique; Larrieu, Marie-Jose

1970-01-01

110

Dr. von Braun Briefing Walt Disney  

NASA Technical Reports Server (NTRS)

Dr. von Braun began his association with Walt Disney in the 1950s when the rocket scientist appeared in three Disney television productions related to the exploration of space. Years later, Dr. von Braun invited Disney and his associates to tour the Marshall Space Flight Center (MSFC) in Huntsville, Alabama. This photograph is dated April 13, 1965. From left are R.J. Schwinghamer from the MSFC, Disney, B.J. Bernight, and Dr. von Braun.

1965-01-01

111

Begutachtung von Pflegebedürftigkeit nach SGBXI  

Microsoft Academic Search

Zusammenfassung Eine der Zielvorgaben des SGB XI ist der ?Vorrang von Prävention und Rehabilitation? vor Pflege. Die GutachterInnen der Medizinischen Dienste führen pro Jahr ca. 1,2Mio. Begutachtungen durch. Nur bei ca. 12% der Betroffenen werden dabei gezielt Rehabilitationsmaßnahmen für notwendig erachtet. Es ist auf den ersten Blick kaum vorstellbar, dass nur so wenige Patienten eine solche Maßnahme benötigen sollen.¶ Es

L. Lürken

2001-01-01

112

Analysenergebnisse einer teilgereinigten Fraktion von Trichophyton mentagrophytes, var. asteroides  

Microsoft Academic Search

E. Mi%LE~, Wiirzburg Aminos~iuren. Uber eine automatische Apparatur zur routinem~ifligen Bestimmung yon Aminosiiuren berichten G. I~A~PITZ und J. WIE~KE 1. Verff. beschreiben die fiir ihre speziellen Zwecke entwickelte Apparatur in Aufbau und Bedienung unter Beigabe yon Abbildungen und Zeichnungen sehr ausfiihrlich. Da sie auch in Futtermitteln, TierkSrpern und physiologischen Fliissigkeiten ]aufend Aminosguren bestimmen, benutzten sie ffir diesen Zweck zusgtzlich eine

B. Müller

1965-01-01

113

Modellierung von Anwenderverhalten im Social Semantic Web  

NASA Astrophysics Data System (ADS)

Ziel dieses Kapitels ist es, gemeinsame Verwendungsszenarien des Semantic Web und des Social Web zu identifizieren und zu benennen. Dabei wird ein Teilaspekt des Themengebiets im Detail betrachtet: die Nutzung von Services, die Beobachtungen des Verhaltens von Anwendern analysieren, um daraus maschinell interpretierbare Informationen zu erhalten und diese als Modelle zu organisieren. Es werden zunächst einige Eigenschaften und Unterscheidungsmerkmale von Anwenderverhalten und organisierten Modellen dargestellt. Anschließend wird der mögliche wechselseitige Nutzen von Anwenderverhalten und Modellen diskutiert. Den Abschluss bildet eine Betrachtung einiger exemplarischer Software-Services, die heute schon verwendet werden, um Anwenderverhalten in Modelle überzuführen.

Ulbrich, Armin; Höfler, Patrick; Lindstaedt, Stefanie

114

Autoradiographische Bestimmung der Dauer der DNS-Verdopplung und der Generationszeit beim Ehrlich-Ascitestumor der Maus durch Doppelmarkierung mit 14 C- und 3 H-Thymidin  

Microsoft Academic Search

Mittels eines Doppelmarkierungs-Verfahrens unter Verwendung von 14C- und 3H-Thymidin und der autoradiographischen Technik wurde die DNS-Verdopplungszeit (S-Phase) und die Generationsdauer bei einem vorwiegend diploiden Stamm des Ehrlich-Ascitestumors der Maus bestimmt. Eine 1. Gruppe von Inzucht-Mäusen wurde am 6. Tag nach Inokulation, d.h. nahe im Stadium des exponentiellen Tumorwachstums, und eine 2. Gruppe am 11. Tag nach Inokulation untersucht.

K. J. Lennartz; W. Maurer

1964-01-01

115

QUANTITATIVE MORPHOLOGY  

EPA Science Inventory

Abstract: In toxicology, the role of quantitative assessment of brain morphology can be understood in the context of two types of treatment-related alterations. One type of alteration is specifically associated with treatment and is not observed in control animals. Measurement ...

116

Herstellung von Chitosan und einige Anwendungen  

Microsoft Academic Search

1. Die Deacetylierung von crabshell - Chitosan führte gleichzeitig zu einem drastischen Abfall der mittleren viscosimetrischen Molmasse ( Mv), insbesondere wenn die Temperatur und die Konzentration an NaOH erhöht werden. Diese Parameter beeinflussten jedoch nicht den Grad der Deacetylierung (DD). Wichtig ist jedoch die Quelle des Ausgangsmaterials: Chitin aus Pandalus borealis ist ein guter Rohstoff für die Herstellung von Chitosan

Marcin Henryk Struszczyk

2001-01-01

117

Dr. Wernher Von Braun greeting dignitaries.  

NASA Technical Reports Server (NTRS)

Dr. Wernher Von Braun, left, greets vice president Spiro T. Agnew in the Launch Control Center for the Apollo 14 mission. Between Dr. Von Braun and Mr. Agnew are their Royal Highnesses, The Prince and Princess of Spain. The royal visitors greeted the launch control team in th enter after the launch of Apollo 14.

1999-01-01

118

Walt Disney and Dr. Wernher von Braun  

NASA Technical Reports Server (NTRS)

Dr. Werhner von Braun, then Chief, Guided Missile Development Operation Division at Army Ballistic Missile Agency (ABMA) in Redstone Arsenal, Alabama, was visited by Walt Disney in 1954. In the 1950's, von Braun worked with Disney Studio as a technical director, making three films about space exploration for television. A model of the V-2 rocket is in background.

1954-01-01

119

Franz Xaver von Zach in England  

NASA Astrophysics Data System (ADS)

F.X. von Zach arrived in London in November 1783, and was employed as tutor to George, son of Count von Brühl, the Saxonian commercial diplomat. Von Zach became a part of von Brühl's household, and was thus in close contact with the leading astronomers, horologists, and scientific instrument makers. Before he departed to Gotha in 1788, he was awarded an honorary degree by Oxford University under false pretences, he upset the Astronomer Royal, and was twice rejected by the Royal Society. At von Brühl's country house he was shown the manuscripts of the mathematician Thomas Harriot (d. 1621); but his attempts to publicise them were hampered by his misreadings, and his treatment of the documents caused confusion in England's scientific community, which lasted throughout his lifetime.

McConnell, Anita

120

Dr. Wernher von Braun Laid to Rest  

NASA Technical Reports Server (NTRS)

Dr. Wernher von Braun served as Marshall Space Flight Center's first director from July 1, 1960 until January 27, 1970, when he was appointed NASA Deputy Associate Administrator for Planning. Following World War II, Dr. von Braun and his German colleagues arrived in the United States under Project Paper Clip to continue their rocket development work. In 1950, von Braun and his rocket team were transferred from Ft. Bliss, Texas to Huntsville, Alabama to work for the Army's rocket program at Redstone Arsenal and later, NASA's Marshall Space Flight Center. Under von Braun's leadership, Marshall developed the Saturn V launch vehicle which took Apollo astronauts to the moon. Dr. von Braun died in Alexandria, Va., on June 16, 1977, seven years after his NASA appointment. This photo was taken at the site where he was laid to rest.

1977-01-01

121

Dr. Wernher von Braun In His Office  

NASA Technical Reports Server (NTRS)

Dr. Wernher von Braun served as Marshall Space Flight Center's first director from July 1, 1960 until January 27, 1970, when he was appointed NASA Deputy Associate Administrator for Planning. Following World War II, Dr. von Braun and his German colleagues arrived in the United States under Project Paperclip to continue their rocket development work. In 1950, von Braun and his rocket team were transferred from Ft. Bliss, Texas to Huntsville, Alabama to work for the Army's rocket program at Redstone Arsenal and later, NASA's Marshall Space Flight Center. Under von Braun's leadership, Marshall developed the Saturn V launch vehicle which took Apollo astronauts to the moon. This photo depicts von Braun in his office at MSFC.

1964-01-01

122

Behandlung von Keratokonus durch Kollagenvernetzung  

Microsoft Academic Search

Zusammenfassung  \\u000a \\u000a Hintergrund. Ziel dieser Studie war der Nachweis, ob sich die Hornhaut bei Keratokonuspatienten mittels photochemischer Riboflavin\\/UVA-Kollagenvernetzung\\u000a verfestigen lässt, um so die progressive Hornhautektasie zu stoppen.\\u000a \\u000a \\u000a \\u000a \\u000a Patienten und Methode. Wir behandelten 16 Augen von 15 Patienten mit gesicherter Progression und überwiegend moderatem Keratokonus.Nach Epithelabrasio\\u000a wurde Riboflavinlösung auf die Hornhaut appliziert und mit UVA aus 1 cm Abstand für 30 min

G. Wollensak; E. Spörl; T. Seiler

2003-01-01

123

A double commutant theorem for Murray-von Neumann algebras  

PubMed Central

Murray–von Neumann algebras are algebras of operators affiliated with finite von Neumann algebras. In this article, we study commutativity and affiliation of self-adjoint operators (possibly unbounded). We show that a maximal abelian self-adjoint subalgebra of the Murray–von Neumann algebra associated with a finite von Neumann algebra is the Murray–von Neumann algebra , where is a maximal abelian self-adjoint subalgebra of and, in addition, is . We also prove that the Murray–von Neumann algebra with the center of is the center of the Murray–von Neumann algebra . Von Neumann’s celebrated double commutant theorem characterizes von Neumann algebras as those for which , where , the commutant of , is the set of bounded operators on the Hilbert space that commute with all operators in . At the end of this article, we present a double commutant theorem for Murray–von Neumann algebras.

Liu, Zhe

2012-01-01

124

Laboratory Diagnosis of von Willebrand Disease Type 1\\/2E (2A Subtype IIE), Type 1 Vicenza and Mild Type 1 Caused by Mutations in the D3, D4, B1–B3 and C1–C2 Domains of the von Willebrand Factor Gene  

Microsoft Academic Search

Autosomal dominant von Willebrand disease (VWD) type 1\\/2E is a quantitative\\/qualitative defect in the von Willebrand factor (VWF) caused by heterozygous cysteine and non-cysteine mutations in the D3 domain of the VWF gene and results in a secretion-multimerization-clearance defect in mutant VWF with the loss of large VWF multimers not due to proteolysis. The multimers of patients with dominant VWD

Alain Gadisseur; Zwi Berneman; Wilfried Schroyens; Jan Jacques Michiels

2009-01-01

125

Propolypeptide of von Willebrand Factor Circulates in Blood and is Identical to von Willebrand Antigen II  

Microsoft Academic Search

The generally mild bleeding disorder of von Willebrand disease is associated with abnormalities of two distinct plasma proteins, the large multimeric von Willebrand factor (vWF), which mediates platelet adhesion, and von Willebrand antigen II (vW AgII), which is of unknown function. The two proteins were found to have a common biosynthetic origin in endothelial cells and megakaryocytes, which explains their

Philip J. Fay; Yohko Kawai; Denisa D. Wagner; David Ginsburg; David Bonthron; Betsy M. Ohlsson-Wilhelm; Stephen I. Chavin; George N. Abraham; Robert I. Handin; Stuart H. Orkin; Robert R. Montgomery; Victor J. Marder

1986-01-01

126

Two cases of peritonsillar abscess complicated by von Willebrand disease.  

PubMed

Von Willebrand disease (vWD) is a common hereditary bleeding disorder resulting from a quantitative and/or qualitative deficiency of von Willebrand factor (vWF). We report two cases of peritonsillar abscess complicated by vWD. A 46-year-old Japanese man was intravenously administered factor VIII clotting antigen (500U×3 days)and platelet transfusion (10U), when before puncture was performed. After puncture, his symptoms promptly improved with the administration of the antibiotic doripenem (DRPM, 1.5g/day). He left our facility one week later and had no recurrence of symptoms. A 24-year-old Japanese woman was intravenously administered factor VIII clotting antigen (4500U×3 days) and desmopressin (DDAVP) before undergoing a puncture. Her symptoms promptly improved with DRPM treatment (1.5g/day). The patient left our facility one week later. However, the peritonsillar abscess recurred in three weeks. Afterwards, tonsillectomy was enforced three months later. Intravenous factor VIII clotting antigen (4500U×2 days) and platelet transfusion (10U×1 day) had been used before tonsillectomy. We therefore suggest that a peritonsillar abscess in patients with vWD can be safely treated by factor VIII clotting antigen and DDAVP at the appropriate disease stage and by performing paracentesis for the acute phase or tonsillectomy for the chronic phase. PMID:22075138

Nagano, Hiromi; Harada, Mizue; Umakoshi, Mizuo; Hayamizu, Yoshiko; Yoshifuku, Kosuke; Kurono, Yuichi

2012-10-01

127

Prophylaxis in von Willebrand disease.  

PubMed

This paper reviews current issues regarding short-term (i.e. for surgery and invasive procedures) and long-term (i.e. regular infusions to prevent bleeding on a permanent or temporary basis) prophylaxis treatment using replacement concentrates for patients with von Willebrand disease (VWD) who do not respond satisfactorily to desmopressin. The standard treatment of these patients is with factor concentrates containing von Willebrand factor (VWF) and factor VIII (FVIII). When dosing these concentrates, the broad variations in content and quality of VWF as well as the FVIII content in the products should be considered. Peri-operative management strategies will depend on the VWD subtype, baseline VWF and FVIII levels, and size of procedure. FVIII level and VWF ristocetin cofactor activity may both be used to determine concentrate potency and to monitor treatment. Long-term prophylaxis, which has become a state-of-the-art approach in haemophilia, is not very common in VWD. However, more recent data suggest that a substantial number of VWD patients could benefit from prophylactic treatment with VWF-containing concentrates. For example, 35 Swedish VWD patients who required prophylaxis (mainly because of nose/mouth bleeds and joint bleeds) showed a substantial overall reduction in bleeding episodes and there were no signs of arthropathy in children who began prophylaxis before the age of 5 years since initiation of treatment with Haemate P/Humate-P. Studies of prophylaxis in VWD are urgently needed to develop evidence-based guidelines for this approach; the VWD International Prophylaxis study, for example, has commenced by the VWD Prophylaxis Network. PMID:18786010

Berntorp, E

2008-11-01

128

How Is von Willebrand Disease Diagnosed?  

MedlinePLUS

... or bone marrow disease, or high or low blood platelet counts. Physical Exam Your doctor will do a ... Willebrand factor ristocetin (ris-to-SEE-tin) cofactor activity. This test shows how well your von Willebrand ...

129

Herstellung von Chitosan und einige Anwendungen  

NASA Astrophysics Data System (ADS)

1. Die Deacetylierung von crabshell - Chitosan führte gleichzeitig zu einem drastischen Abfall der mittleren viscosimetrischen Molmasse ( Mv), insbesondere wenn die Temperatur und die Konzentration an NaOH erhöht werden. Diese Parameter beeinflussten jedoch nicht den Grad der Deacetylierung (DD). Wichtig ist jedoch die Quelle des Ausgangsmaterials: Chitin aus Pandalus borealis ist ein guter Rohstoff für die Herstellung von Chitosan mit niedrigem DD und gleichzeitig hoher mittlerer Mv, während Krill-Chitin (Euphausia superba) ein gutes Ausgangsmaterial zur Herstellung von Chitosan mit hohem DD und niedrigem Mv ist. Chitosan, das aus Insekten (Calliphora erythrocephala), unter milden Bedingungen (Temperatur: 100°C, NaOH-Konzentration: 40 %, Zeit: 1-2h ) hergestellt wurde, hatte die gleichen Eigenschaften hinsichtlich DD und Mv wie das aus Krill hergestellte Chitosan. Der Bedarf an Zeit, Energie und NaOH ist für die Herstellung von Insekten-Chitosan geringer als für crabshell-Chitosan vergleichbare Resultaten für DD und Mv. 2. Chitosan wurde durch den Schimmelpilz Aspergillus fumigatus zu Chitooligomeren fermentiert. Die Ausbeute beträgt 25%. Die Chitooligomere wurden mit Hilfe von HPLC und MALDI-TOF-Massenspektrmetrie identifiziert. Die Fermentationsmischung fördert die Immunität von Pflanzen gegen Bakterien und Virusinfektion. Die Zunahme der Immunität schwankt jedoch je nach System Pflanze-Pathogen. Die Fermentation von Chitosan durch Aspergillus fumigatus könnte eine schnelle und billige Methode zur Herstellung von Chitooligomeren mit guter Reinheit und Ausbeute sein. Eine partiell aufgereinigte Fermentationsmischung dieser Art könnte in der Landwirtschaft als Pathogeninhibitor genutzt werden. Durch kontrollierte Fermentation, die Chitooligomere in definierter Zusammensetzung (d.h. definierter Verteilung des Depolymerisationsgrades) liefert, könnte man zu Mischungen kommen, die für die jeweilige Anwendung eine optimale Bioaktivität besitzen. 3. Die aus Chitosan-Dispersionen hergestellten MCChB-Filme weisen bessere mechanische Eigenschaften (Bruchfestigkeit, Dehnung) und eine höhere Wasseraufnahmefähigkeit auf als Filme, die nach herkömmlichen Methoden aus sauerer Lösung hergestellt werden. Die Einführung von Proteinen ändert die mechanischen Eigenschaften der MCChB-Filme abhängig von der Art, der Proteine sowie des DD und der Mv des eingesetzte Chitosan. Die Zugabe von Protein beschleunigt den biologischen Abbau der MCChB-Filme. Aus den untersuchten MCChB-Filmen mit Proteinzusatz können leichte, reißfeste und dennoch elastische Materialen hergestellt werden. 4. Mit Hilfe von MCChB-Dispersion kann Papier modifiziert werden. Dadurch werden die mechanischen Eigenschaften verbessert und die Wasseraufnahme wird verringert. Die Zugabe von Proteinen verringert das Wasseraufnahmevermögen noch weiter. Ein geringes Wasseraufnahmevermögen ist der bedeutendste Faktor bei der Papierherstellung. Auch Papier, das mit einem MCChB-Protein-Komplexe modifiziert wurde, zeigt gute mechanische Eigenschaften. 5. Wird Chitosan durch unmittelbare Einführung von MCChB auf Cellulose-Fasern aufgebracht, so erhält man eine netzartige Struktur, während durch Ausfällung aufgebrachtes Chitosan eine dünne Schicht auf den Cellulose-Fasern bildet. Die netzartige Struktur erleichtert die Bioabbaubarkeit, während die Schichtstruktur diese erschwert. 6. Die guten mechanischen Eigenschaften, die geringe Wasseraufnahmefähigkeit und die mit Cellulose vergleichbare Bioabbaubarkeit von Papier, das mit MCChB modifiziert wurde, lassen MCChB für die Veredlung von Papier nützlich erscheinen. 1. Deacetylation of the crustacean chitosan causes drastically decrease in the Mv with increasing reaction temperature and time as well as the concentration of sodium hydroxide. However, the DD are relatively less affected. Pandalus borealis is a good source for production of chitosan having high Mv and low DD, whereas chitosan of medium to low Mv can ideally be prepared using krill chitin. Insect chitosan is prepared under milder condition a

Struszczyk, Marcin Henryk

2001-05-01

130

Die Wirkung von polarisiertem Licht auf Kokain  

Microsoft Academic Search

Zusammenfassung 1.Bestrahlung von Kokainlösungen mit polarisiertem Licht wurden auf zwei einwandfreie Arten vorgenommen: mittels eines Nicolschen Prismas und mittels Glasplattensätzen, die im Brewsterschen Winkel aufgestellt wurden.2.Diese Lösungen wurden mit Kontrollösungen, welche nichtpolarisiertem Licht von genau der gleichen Intensität und Wellenlänge für die gleiche Zeitdauer ausgesetzt worden waren, sowie mit gar nicht bestrahlten Lösungen verglichen.3.Solche Vergleichsstudien wurden durch eine große Anzahl

David I. Macht; Harriet Leach

1929-01-01

131

Avatare und die Usability von Websites  

Microsoft Academic Search

\\u000a Durch den Einsatz von Avataren (der Begriff wird hier auf animierte Agenten, virtuelle Verkäufer bzw. Berater, „Chat-Bots“\\u000a oder „Chatterbots“ bezogen) verändert sich die Interaktion des Benutzers mit dem Computer grundlegend. Fenster, Buttons und\\u000a Menüs verschwinden im wahrsten Sinn des Wortes von der Bildfläche. Sie werden ersetzt durch grafisch mehr oder weniger aufwändig\\u000a gestaltete Charaktere, mit denen der Benutzer interagiert. Die

Thomas Wirth

132

Dr. von Braun With Management Team  

NASA Technical Reports Server (NTRS)

Dr. von Braun is shown in this photograph, which was probably taken in the early 1960s, with members of his management team. Pictured from left to right are, Werner Kuers, Director of the Manufacturing Engineering Division; Dr. Walter Haeussermarn, Director of the Astrionics Division; Dr. William Mrazek, Propulsion and Vehicle Engineering Division; Dr. von Braun; Dieter Grau, Director of the Quality Assurance Division; Dr. Oswald Lange, Director of the Saturn Systems Office; and Erich Neubert , Associate Deputy Director for Research and Development.

1961-01-01

133

Dr. von Braun With German Rocket Experimenters  

NASA Technical Reports Server (NTRS)

Dr. von Braun was among a famous group of rocket experimenters in Germany in the 1930s. This photograph is believed to be made on the occasion of Herman Oberth's Kegelduese liquid rocket engine being certified as to performance during firing. From left to right are R. Nebel, Dr. Ritter, Mr. Baermueller, Kurt Heinish, Herman Oberth, Klaus Riedel, Wernher von Braun, and an unidentified person.

1930-01-01

134

Glanzmann's thrombasthenia with mild von Willebrand's disease.  

PubMed Central

A Saudi Arabian family is reported in which Glanzmann's thrombasthenia and von Willebrand's disease occurred simultaneously. The daughter presented with menorrhagia and gave a history of gastrointestinal bleeding and a strong family history of bleeding disorder. Full haematological investigations were performed on the propositus, parents, and siblings, including complete blood count, bleeding time, prothrombin time, partial thromboplastin time, factor VIII:C, von Willebrand factor, ristocetin cofactor, platelet aggregometry, platelet glycoprotein Ib and IIb/IIIa and platelet antigen PLT-1 (Coulter Clone). The propositus had Glanzmann's thrombasthenia, both parents had mild von Willebrand's disease and were carriers of Glanzmann's thrombasthenia. Three symptomatic brothers had both Glanzmann's thrombasthenia and von Willebrand's disease; two asymptomatic brothers had von Willebrand's disease only and one had completely normal results. Those family members with both diseases were more severely affected than those with just one disease. In areas where consanguineous marriage is common, such as Saudi Arabia, multiple haemostatic abnormalities may occur, and investigation should not stop with the discovery of a single abnormality. The increased clinical severity of bleeding, including haemarthroses, in those patients having both congenital defects emphasises the importance of von Willebrand factor in glycoprotein Ib-mediated platelet adhesion.

Nounou, R; Spence, D

1993-01-01

135

Reduced von Willebrand factor survival in type Vicenza von Willebrand disease  

Microsoft Academic Search

Type Vicenza variant of von Willebrand disease (VWD) is characterized by a low plasma von Willebrand factor (VWF) level and supranormal VWF multimers. Two candidate mutations, G2470A and G3864A at exons 17 and 27, respectively, of the VWF gene were recently reported to be present in this disorder. Four additional families, originating from northeast Italy, with both mutations of type

Alessandra Casonato; Elena Pontara; Francesca Sartorello; Maria Grazia Cattini; Maria Teresa Sartori; Roberto Padrini; Antonio Girolami

136

Feinstrukturen der Merozoiten von Babesia bigemina im Ovar von Boophilus microplus und Boophilus decoloratus  

Microsoft Academic Search

Merozoiten („Vermicula“) und sphäroide Formen von Babesia bigemina im Ovar von Boophilus microplus und B. decoloratus wurden elektronenmikroskopisch untersucht:1.Die sphäroiden Formen liegen in einer parasitophoren Vakuole und transformieren sich dort zu vielfach eingefalteten Merozoiten. Die isolierenden Membranen der parasitophoren Vakuole stehen z.T. mit Membranen des endoplasmatischen Reticulums der Wirtszelle in Verbindung. Die Differenzierung der Merozoiten ist im wesentlichen abgeschlossen, bevor

Karl Friedhoff; Erich Scholtyseck

1969-01-01

137

von Hippel-Lindau syndrome.  

PubMed

von Hippel-Lindau (VHL) disease is an autosomal-dominant familial cancer syndrome associated with mutations of the VHL tumor suppressor gene (3p25-26). Its estimated incidence ranges from 1 in 36,000 to 1 in 53,000 with a penetrance of up to 95% by age 60. Genotype-phenotype correlation divides VHL into two broad clinical subtypes. Type 1 VHL is predominantly associated with large deletion or truncation mutations which result in an encoded protein with very little or no activity. It is associated with retinal and CNS hemangioblastoma and renal cell carcinoma but not pheochromocytoma. Type 2 is usually associated with missense mutations encoding a protein with limited activity and includes pheochromocytoma. It is further classified into three other subtypes (2A, 2B, 2C) based on the presence of hemangioblastoma and renal cell carcinoma. Visceral cysts in the kidney, pancreas and epididymis, nonfunctioning pancreatic neuroendocrine tumors which often show distinctive clear cell cytology, endolymphatic sac tumors and head and neck paragangliomas are well recognized but less common presenting features. Surveillance of carriers can reduce the burden of disease and is best performed in specialist referral centers with due consideration given to both the complex molecular pathogenesis and psychosocial aspects of the disease. PMID:23652669

Chou, Angela; Toon, Christopher; Pickett, Justine; Gill, Anthony J

2013-01-01

138

Dr. Wernher Von Braun with Dr. Christian Barnard.  

NASA Technical Reports Server (NTRS)

Dr. Christian Barnard Tours Marshall Space Flight Center. Shown in Dr. Von Braun's office are (left to right): Dr. Ernst Sthulinger, a representative from General Electric, Dr. Wernher Von Braun, Dr. Christian Barnard, and Dr. Eberhard Rees.

1999-01-01

139

Elimination von H 3 -g-Strophanthin durch Hämodialyse  

Microsoft Academic Search

Zusammenfassung Bei anurischen Patienten fand sich nach intravenöser Applikation von H3-g-Strophanthin eine erhebliche Verlängerung der Halbwertszeit von Serumradioaktivität (anurische Patienten:t1\\/2=60 h; nierengesunde Versuchspersonen:t1\\/2=14 h). Während einer 8–10stündigen Hämodialyse mit der Ultraflo-145-Spule wurden 11–19% der verabreichten Dosis eliminiert. Das entspricht etwa 40 bis 60% der Menge von Radioaktivität, die im gleichen Zeitraum von nierengesunden Versuchspersonen mit dem Urin ausgeschieden wird.

P. Kramer; J. Horenkamp; E. Quellhorst; F. Scheler

1970-01-01

140

Experimental Determination of the Thermal Conductivity of Air and Air/Water Vapor Mixtures in the Temperature Range Between 2000 K and 7000 K Experimentelle Bestimmung der Waermeleitfaehigkeit von Luft/ Wasserdampfgemischen im Temperaturbereich 2000 K Bis 7000 K.  

National Technical Information Service (NTIS)

An experimental technique which allows heat conductivity to be determined in hot gas mixtures is described for use in heat transfer calculations in the hypersonic range. A laser differential interferometer was used to determine the density distribution in...

G. Smeets

1975-01-01

141

Wechselwirkung von NO(sub 3)-Radikalen mit waessrigen Loesungen: Bestimmung des Henry- und des Massenakkommodationskoeffizienten. (Interaction of NO(sub 3) radicals with aqueous solutions: Estimation of the Henry coefficient and the mass accommodation coefficient).  

National Technical Information Service (NTIS)

The Henry coefficient of NO(sub 3) radicals, K(sub h)(NO(sub 3)), was studied in coiled denuder tubes of 2 mm diameter and variable length, e.g. 4-350 cm. The radicals were produced in a flow system by oxidation of NO with excess O(sub 3) at a temperature...

K. Thomas A. Volz-Thomas D. Kley

1993-01-01

142

Determination of actual evapotranspiration and crop coefficients of broad bean (Vicia Faba L.) grown under field conditions in the jordan valley, jordan: Bestimmung der aktuellen evapotranspiration und pflanzenbestandskoeffizienten von bohnen (Vicia Faba L.) unter feldbedingungen im jordantal, jordanien  

Microsoft Academic Search

This study was conducted to determine actual evapotranspiration and crop coefficients at different growth stages of broad bean (Vicia faba L.) grown in an open field in the Jordan Valley, Jordan using a precise and accurate approach. The study involved 30-min fluxes measurements of energy budget components over broad bean crop using a complete setup of an Eddy Correlation (EC)

Jumah Amayreh; Nassim Al-Abed

2003-01-01

143

Vergleich zweier radioenzymatischer Methoden zur Bestimmung von Noradrenalin im Plasma (COMT-Assay und PNMT-Assay). (Comparative evaluation of two radioenzymatic procedures designed to determine noradrenaline in the plasma (COMT assay and PNMT assay)).  

National Technical Information Service (NTIS)

A comparative evaluation of two radioenzymatic procedures to determine the concentration of noradrenaline in the plasma - with linearity, sensitivity, specifity and accuracy serving as test criteria - led to the following results: In view of a probability...

A. Barth

1984-01-01

144

Dr. von Braun Surrenders to U.S. Army  

NASA Technical Reports Server (NTRS)

Dr. Wernher von Braun surrenders to U.S. Army Counterintelligence persornel of the 44th Infantry Division in Ruette, Bavaria on May 2, 1945. Left to right are Charles Stewart, CIC agent; Dr. Herbert Axster; Dieter Huzel; Dr. von Braun (arm in cast); Magnus von Braun (brother); and Hans Lindenberg.

1945-01-01

145

Storage and Secretion of von Willebrand Factor by Endothelial Cells  

Microsoft Academic Search

Endothelial cells synthesize and store von Willebrand factor. We have studied the storage and secretion of von Willebrand factor in cultured human umbilical vein endothelial cells. In particular, we were interested in the nature of the storage compartment and the effects of perturbation on the storage and secretion processes. The storage compartment for von Willebrand factor was isolated from homogenates

Jan Hendrik Reinders; Philip G. de Groot; Jan J. Sixma; Jan A. van Mourik

1988-01-01

146

Sammlung von Kulturpflanzen-Landsorten im Irak 1986  

Microsoft Academic Search

Zusammenfassung Im Juni 1986 wurde im Irak eine Sammelreise durchgeführt. Landsorten von Getreide, Gemüsen und einigen anderen Kulturpflanzen konnten gesammelt werden; insgesamt 141 Proben. Die Generosion ist bei den Getreiden schon weit fortgeschritten. Durch die Einführung vieler neuer Gemüsesorten muß in den nächsten Jahren mit einem empfindlichen Verlust von Gemüse-Landsorten gerechnet werden. Das Sammelmaterial ist von großer Bedeutung für die

Karl Hammer; Adel A. Sabir

1987-01-01

147

Economic Programming and the von Neumann Model: Some Planning Techniques.  

National Technical Information Service (NTIS)

The essays are concerned with generalizations, extensions, and applications of the von Neumann model. The essays all have in common a 'how to' approach: Chapter II shows how to decompose a von Neumann model or an input-output model and how von Neumann exp...

R. L. Weil G. L. Thompson M. J. Hamburger

1966-01-01

148

Dr. Wernher Von Braun talkes with George Hardy.  

NASA Technical Reports Server (NTRS)

George Hardy of the Marshall Space Flight center's Astronautics Laboratory, talks with Dr. Wernher Von Braun (right), deputy associate administrator for planning. Dr. Von Braun was inspecting the mockup of the Saturn workshop during a visit to the Marshall Center. The visit coincided with the 10th anniversary celebration of the center of which Dr. Von Braun was director until March 1, 1970.

1999-01-01

149

Fundamentals of quantitative research  

Microsoft Academic Search

The main purpose of this article is to introduce some important fundamental concepts of quantitative research to readers especially novice researchers. It comprises types of research, definitions of quantitative research, different types and assumptions of quantitative research, when to use and not to use quantitative methods, advantages, common approaches and samples of quantitative research, and common misconceptions. Besides, a set

Suphat Sukamolson

150

Level-Set-Segmentierung von Rattenhirn MRTs  

NASA Astrophysics Data System (ADS)

In dieser Arbeit wird die Segmentierung von Gehirngewebe aus Kopfaufnahmen von Ratten mittels Level-Set-Methoden vorgeschlagen. Dazu wird ein zweidimensionaler, kontrastbasierter Ansatz zu einem dreidimensionalen, lokal an die Bildintensität adaptierten Segmentierer erweitert. Es wird gezeigt, dass mit diesem echten 3D-Ansatz die lokalen Bildstrukturen besser berücksichtigt werden können. Insbesondere Magnet-Resonanz-Tomographien (MRTs) mit globalen Helligkeitsgradienten, beispielsweise bedingt durch Oberfiächenspulen, können auf diese Weise zuverlässiger und ohne weitere Vorverarbeitungsschritte segmentiert werden. Die Leistungsfähigkeit des Algorithmus wird experimentell an Hand dreier Rattenhirn-MRTs demonstriert.

Eiben, Björn; Kunz, Dietmar; Pietrzyk, Uwe; Palm, Christoph

151

Diagnosis and management of von Willebrand disease in Australia.  

PubMed

Von Willebrand disease (VWD) is the most common inherited bleeding disorder and arises from deficiencies and/or defects in the plasma protein Von Willebrand factor (VWF). VWD is classified into six different types, with type 1 identifying a (partial) quantitative deficiency of VWF, type 3 defining a (virtual) total deficiency of VWF, and type 2 identifying four separate types (2A, 2B, 2M, and 2N) characterized by qualitative defects. The classification is based on phenotypic assays including factor VIII coagulant, VWF antigen, and VWF activity, primarily by ristocetin cofactor and collagen binding, as supplemented by additional testing. In Australia, >30 pathology-based laboratories perform VWD testing, and tests and test panels reflect a wide variety of practice. In our own referral laboratory, diagnosis is a staged process reflecting a combination of clinical and laboratory findings with a large panel of tests. We also use data from desmopressin trials to assist in VWD type assignment. The current report presents an overview of the VWD diagnostic process as applied within Australia, includes summary data from the Australian Bleeding Disorders Registry, and provides specific details of the diagnostic and management practice undertaken in our reference laboratory, which also maintains a local bleeding disorders database. This database currently contains 4070 entries, including 1832 suspected or confirmed cases of VWD. Excluding 311 as yet unclassified cases, 1254 cases (82.4%) would define (potential) quantitative deficiencies of VWF ("low VWF" or type 1 VWD), 241 (15.8%) qualitative defects (type 2 VWD), and 23 (1.5%) type 3 VWD. Most of the quantitative defects reflect only mild loss of VWF, and <15% of total cases would be identified to have VWF levels <35 U/dL. Most cases of type 2 remain unclassified (34.9%) because available data are limited. Type 2A and 2M VWD represent the most common qualitative defects, representing 22.8% and 22.2% of defined type 2 VWD cases. Type 2B and 2N reflect 8.3% and 12.9%, respectively, of type 2 VWD cases. PMID:22102198

Favaloro, Emmanuel J; Bonar, Roslyn; Favaloro, James; Koutts, Jerry

2011-07-01

152

Untersuchungen über die Wirkung von Bakterien-und Bakteriophagen-Präparaten auf Carcinom-und Normalgewebe in der Gewebekultur  

Microsoft Academic Search

Zusammenfassung Es werden Versuche über die Beeinflussung von Carcinomgewebe und Normalgewebe durch Bakterien- und Bakteriophagenpräparate in der Gewebekultur mitgeteilt. Unter den zahlreichen geprüften Bakteriophagenlysaten sind 5 Lysate von besonderer Wirksamkeit, und zwar von Bac. subtilis (Stamm SG 55), von Bact. coli (Stamm SG 134), von Bact. dysenteriae Flexner A (Stamm SG 59), von Strept. ovalis (Stamm SG 95) und von

Hildegard Vollmar; Hans Knöll

1944-01-01

153

Erweiterung des Verfahrens von Holzer-Tolle auf die Berechnung von Dreheigenschwingungszahlen nach Torsion zweiter Art  

Microsoft Academic Search

Es wird eine Erweiterung des Verfahrens vonHolzer-Tolle angegeben, die es ermöglicht, für Schwingungsanordnungen mit beliebigen Drehmassen und beliebigen Drehsteifen die Dreheigenschwingungszahlen beliebigen Grades auf Grund der Torsion zweiter Art mit Berücksichtigung der Nebentorsion verhältnismäßig einfach zu ermitteln.

A. Kimmel; M. Läpple

1941-01-01

154

Type 2M von Willebrand disease variant characterized by abnormal von Willebrand factor multimerization  

Microsoft Academic Search

We describe a von Willebrand disease (VWD) variant characterized by low plasma and platelet von Willebrand factor (VWF), impaired ristocetin-induced VWF binding to platelet glycoprotein Ib (GPIb), and abnormal VWF multimer pattern not associated with the absence of large forms. A C-to-T transition at nucleotide 4120 in exon 28 of the VWF gene was found; this mutation introduces a cysteine

A. Casonato; E. Pontara; F. Sartorello; A. Bertomoro; C. Durante; A. Girolami

2001-01-01

155

Evaluation of an Automated von Willebrand Factor Activity Assay in von Willebrand Disease  

Microsoft Academic Search

We evaluated the use of the turbidimetric HemosIL von Willebrand Factor (VWF) Activity assay (VWF:Act) on the STA-R automated coagulometer (Stago, Asnières, France) for the diagnosis of von Willebrand disease (VWD). For this, we prospectively screened 268 patients. As a second part, we retrospectively assayed 111 patients with well-defined VWD subtype. In the first prospective study, we demonstrate that in

Marc Trossaërt; Catherine Ternisien; Armelle Lefrancois; Laura Llopis; Jenny Goudemand; Marianne Sigaud; Marc Fouassier; Claudine Caron

2011-01-01

156

Weitere Untersuchungen über die Wirkung von Aneurin und Biotin auf das Wachstum von Wurzelpilzen  

Microsoft Academic Search

1.Die vorliegende Untersuchung behandelt in erster Linie den Einfluß von Aneurin in suboptimalen Mengen auf das Wachstum von Clitopilus Prunulus (Scop.) Fr., Boletus luteus (L.) Fr. und B. variegatus (Sw.) Fr.2.Aneurin hatte bei diesen Pilzen eine überaus starke stimulierende Wirkung auf die Wachstumsgeschwindigkeit.3.Der Verlauf der Wachstumskurven scheint darauf hinzudeuten, daß die Pilze bei diesen Versuchen nicht die Fähigkeit besaßen, selbst

Elias Melin; Birgitta Nyman

1940-01-01

157

Echtzeitverhalten durch die Verwendung von CPU Stubs: Eine Erweiterung von Dynamic Performance Stubs  

NASA Astrophysics Data System (ADS)

Dynamic Performance Stubs realisieren ein Framework zur Simulation des Performanzverhaltens von Softwaremodulen und Funktionen. Sie können für eine Kosten-Nutzen-Analyse einer potentiellen Performanzoptimierung verwendet werden. Dies führt zu einer ergebnisorientierten Optimierung. Ebenso ist es möglich versteckte Flaschenhälse und die wichtigsten Optimierungskandidaten zu identifizieren. Dieser Bericht beschreibt CPU Stubs im Detail und evaluiert Einsatzmöglichkeiten, um CPU gebundene Flaschenhälse zu optimieren. Durch die Optimierung wird das Einhalten von harten oder weichen Echtzeitbedingungen ermöglicht.

Trapp, Peter; Facchi, Christian; Meyer, Markus

158

Temperature-Dependence of Weibel-Palade Body Exocytosis and Cell Surface Dispersal of von Willebrand Factor and Its Propolypeptide  

Microsoft Academic Search

BackgroundWeibel-Palade bodies (WPB) are endothelial cell (EC) specific secretory organelles containing Von Willebrand factor (VWF). The temperature-dependence of Ca2+-driven WPB exocytosis is not known, although indirect evidence suggests that WPB exocytosis may occur at very low temperatures. Here we quantitatively analyse the temperature-dependence of Ca2+-driven WPB exocytosis and release of secreted VWF from the cell surface of ECs using fluorescence

Lindsay Hewlett; Gregor Zupan?i?; Gregory Mashanov; Laura Knipe; David Ogden; Matthew J. Hannah; Tom Carter

2011-01-01

159

Carl Von Clausewitz: Two Letters on Strategy.  

National Technical Information Service (NTIS)

This edition of Carl von Clausewitz's Two Letters on Strategy was made possible by the Army War College Foundation and by the Art of War Colloquium of the Army War College, which sponsors the volume as part of its program of republishing military classics...

D. Moran P. Paret

1984-01-01

160

Auftreten von viren in Aesculus hippocastanum L  

Microsoft Academic Search

In den Jahren 1992 bis 1995 wurden 954 Roßkastanien (Aesculus hippocastanum L. und A. × carnea Hayne) auf Befall mit Viren geprüft. Als Untersuchungsmethoden kamen eine Simultanvariante des DAS?ELISA sowie ein biologischer Test (mechanische Inokulation von Chenopodium quinoa Willd.) zum Einsatz. Insgesamt ergab sich eine relativ geringe Virusbelastung. Etwa 1% aller geprüften Bäume waren mit dem strawberry latent ringspot virus

Torsten Hentsch; Egon Fuchs; Maria Grüntzig; Frank Otto

1996-01-01

161

Guido von Pirquet: Austrian pioneer of astronautics  

NASA Technical Reports Server (NTRS)

The works of Guido von Pirquet, Austrian pioneer of rocketry, were assessed. Major emphasis was given to Pirquet's calculation of the route to Venus which in fact was followed by the first Russian rocket to Venus. Of interest also is Pirquet's valuable construction of a space station and his analysis of interstellar space flight.

Sykora, F.

1977-01-01

162

Die Usability von Rich Internet Applications  

NASA Astrophysics Data System (ADS)

Interaktiven Services, die dem Themenkreis Web 2.0 zugeordnet werden, haftet unter anderem das Attribut an, besonders leicht bedienbar zu sein. Flickr, Youtube und Wikipedia gelten als Erfolgsprojekte dieser neuen Art von interaktiven Websites. Wodurch zeichnet sich nun eine Usability 2.0 (so es sie überhaupt geben sollte) aus? Was ist zu beachten, wenn so genannte Rich Internet Applications gestaltet werden?

Linder, Jörg

163

Fredholm Theories in von Neumann Algebras.  

National Technical Information Service (NTIS)

The theory of compact and of Fredholm operators of a Hilbert space has been generalized in various directions by several authors. In the present paper the foundations of a generalization of this theory to von Neumann algebras are laid. This generalization...

M. Breuer

1967-01-01

164

Theory of Growth: The von Neumann Revolution.  

National Technical Information Service (NTIS)

Economic growth is examined using the Von Neumann model which permits joint production and treats fixed capital goods of different vintages as different goods. The existence of a balanced growth of all outputs with continued full employment of labor is es...

M. Morishima

1964-01-01

165

Can Dataflow Subsume von Neumann Computing?  

Microsoft Academic Search

Abstract: We explore the question: “What can a von Neumann,processor borrow,from dataflow to make it more suitable for a , dataflow capability. We call the result P-RISC, for “Parallel FUSC.” Finally, we discuss memory support for such multiprocessors. We compare,our approach to existing MIMD machines,and to other dataflow machines. Keywords and phrases: parallelism, MIMD, data-

Rishiyur S. Nikhil

1989-01-01

166

MINIMUM MODULI IN VON NEUMANN ALGEBRAS  

Microsoft Academic Search

In this paper we answer a question raised in [12] in the affirmative, namely that the essential minimum modulus of an element in a von Neumann algebra, relative to any norm closed two-sided ideal, is equal to the minimum modulus of the element perturbed by an element from the ideal. As a corollary of this result, we extend some basic

Perumal Gopalraj; Anton StröH

2001-01-01

167

Dr. Wernher Von Braun presents a certificate  

NASA Technical Reports Server (NTRS)

Dr. Wernher Von Braun (left), director of the Marshall Space Flight Center, presents a humorous certificate to Major General Charles W. Eifler, commanding general of Redstone Arsenal, at the close of a farewell luncheon for the general prior to General Eifler moving to a new European duty station.

1999-01-01

168

Entwicklung von Landnutzungsszenarien für landschaftsökologische Fragestellungen  

NASA Astrophysics Data System (ADS)

Die Landschaften Mitteleuropas sind das Resultat einer langwierigen Geschichte menschlicher Landnutzung mit ihren unterschiedlichen, z.T. konkurrierenden Nutzungsansprüchen. Durch eine überwiegend intensive Beanspruchung haben die direkten und indirekten Auswirkungen der Landnutzung in vielen Fällen zu Umweltproblemen geführt. Die Disziplin der Landschaftsökologie hat es sich zur Aufgabe gemacht, Konzepte für eine nachhaltige Nutzung der Landschaft zu entwickeln. Eine wichtige Fragestellung stellt dabei die Abschätzung der möglichen Folgen von Landnutzungsänderungen dar. Für die Analyse der relevanten Prozesse in der Landschaft werden häufig mathematische Modelle eingesetzt, welche es erlauben die Landschaft unter aktuellen Verhältnissen oder hinsichtlich veränderter Rahmenbedingungen zu untersuchen. Die hypothetische Änderung der Landnutzung, die als Landnutzungsszenario bezeichnet wird, verkörpert eine wesentliche Modifikation der Rahmenbedingungen, weil Landnutzung mageblich Einfluss auf die natürlichen Prozesse der Landschaft nimmt. Während die Antriebskräfte einer solchen Änderung überwiegend von sozio-ökonomischen und politischen Entscheidungen gesteuert werden, orientiert sich die exakte Verortung der Landnutzungsänderungen an den naturräumlichen Bedingungen und folgt z.T. erkennbaren Regeln. Anhand dieser Vorgaben ist es möglich, räumlich explizite Landnutzungsszenarien zu entwickeln, die als Eingangsdaten für die Modellierung verschiedener landschaftsökologischer Fragestellungen wie z.B. für die Untersuchung des Einflusses der Landnutzung auf den Wasserhaushalt, die Erosionsgefahr oder die Habitatqualität dienen können. Im Rahmen dieser Dissertation wurde das rasterbasierte deterministische Allokationsmodell luck (Land Use Change Scenario Kit) für die explizite Verortung der Landnutzungsänderungen entwickelt. Es basiert auf den in der Landschaftsökologie üblichen räumlichen Daten wie Landnutzung, Boden sowie Topographie und richtet sich bei der Szenarienableitung nach den Leitbildern der Landschaftsplanung. Das Modell fut auf der Hypothese, dass das Landnutzungsmuster als Funktion seiner landschaftsökologischen Faktoren beschrieben werden kann. Das Veränderungspotenzial einer Landnutzungseinheit resultiert im Modell aus einer Kombination der Bewertung der relativen Eignung des Standortes für die jeweilige Landnutzung und der Berücksichtigung von Standorteigenschaften der umliegenden Nachbarn. Die Durchführung der Landnutzungsänderung im Modell ist iterativ angelegt, um den graduellen Prozess des Landschaftswandels nachvollziehen zu können. Als Fallbeispiel für die Anwendung solcher räumlich expliziten Landnutzungsszenarien dient die Fragestellung, inwieweit Landnutzungsänderungen die Hochwasserentstehung beeinflussen. Um den Einfluss auf die Hochwasserentstehung für jede der Landnutzungskategorien – bebaute, landwirtschaftlich genutzte und naturnahe Flächen – abschätzen zu können, wird im Landnutzungsmodell luck exemplarisch für jede Kategorie ein Teilmodell für die Veränderung von Landnutzung angeboten: 1) Ausdehnung der Siedlungsfläche: Dieses Teilmodell fut auf der Annahme, dass sich Siedlungen nur in direkter Nachbarschaft bereits bestehender Bebauung und bevorzugt entlang von Entwicklungsachsen ausbreiten. Steile Hangneigungen stellen für potenzielle Standorte ein Hemmnis bei der Ausbreitung dar. 2) Stilllegung von Grenzertragsackerflächen: Gemä der Hypothese, dass sich die Stilllegung von Ackerflächen an der potenziellen Ertragsleistung der Standorte orientiert, werden in diesem Teilmodell alle Ackerstandorte dahingehend bewertet und die Flächen mit der geringsten Leistungsfähigkeit stillgelegt. Bei homogenen Gebietseigenschaften werden die Stilllegungsflächen zufällig auf die Ackerfläche verteilt. 3) Etablierung von Schutzgebieten in Ufer- und Auenbereichen: Ausgehend von der These, dass sich entlang von Flüssen sensible Flächen befinden, deren Schutz positive Folgen für das Leistungsvermögen der Landschaft haben kann, w

Fritsch, Uta

2002-04-01

169

Möglicher Einfluß von Immissionen auf die Spurenelementversorgung wildlebender Wiederkäuer: Selen als Beispiel  

Microsoft Academic Search

Großflächige Umwelteinflüsse können auch abgelegene Naturschutzgebiete beeinflussen. Saure Prezipitation, Immissionen von Schwefel und Stickstoffverbindungen und Immissionen und Liberalisierung von Schwermetallen können u. a. die zyklischen Prozesse von Spurenelementen beeinflussen. Die Löslichkeit von Selen (Se) z. B. ist vom pH abhängig. Eine Versäuerung des Bodens reduziert den Selengehalt der Pflanzen und damit der Herbivoren. Sodann wird Se von Schwermetallen gebunden, was

W. T. Flueck

1990-01-01

170

Intravasale Persistenz, Gewebsspeicherung und Ausscheidung von Hydroxyäthylstärke (HÄS)  

Microsoft Academic Search

Zusammenfassung HÄS ist als Derivat des Amylopektins dem verzweigten Alpha-1,4-Glukose-Polymer Glykogen ähnlich. Durch Hydroxyäthylierung wird die Hydrolyse durch ?-Amylase verzögert. Tragen 70 bis 90 % der Glukose-Polymer-Einheiten Hydroxyäthylgruppen, so sind die intravasale Verweildauer und die Urinausscheidung von HÄS bei einem Molekulargewicht von 435 000 vergleichbar mit denen von Dextran 70. HÄS und Dextran 70 werden vorübergehend in den Retikuloendothelial- und

W. L. Thompson; T. Fukushima; R. B. Rutherford; R. P. Walton

1979-01-01

171

Neogene Ostracodenfaunen im Gebiet südlich von Thessaloniki (Nordgriechenland)  

Microsoft Academic Search

Kurzfassung  Die Bearbeitung der Ostracodenfauna des Neogens im Gebiet südlich von Thessaloniki (Nordgriechenland) hat zu mehreren überraschenden\\u000a Ergebnissen geführt, die eine bessere Beurteilung der paläobiogeographischen Beziehungen des Neogens von Nordgriechenland\\u000a ermöglichen und vielleicht auch zu verläßlicheren Aussagen hinsichtlich seiner stratigraphischen Position führen werden. Die\\u000a Fauna erlaubt präzise Korrelationen der Trilophos-Formation mit den zeitlich entsprechenden Profilen aus dem Gebiet von Katerini\\u000a sowie

Nasser Mostafawi

1996-01-01

172

Portrait of Dr. Von Braun with Walt Disney, 1954.  

NASA Technical Reports Server (NTRS)

Marshall Center Director Dr. Wernher Von Braun is pictured with Walt Disney during a visit to the Marshall Space Flight Center in 1954. In the 1950s, Dr. Von Braun while working in California on the Saturn project, also worked with Disney studios as a technical director in making three films about Space Exploration for television. Disney's tour of Marshall in 1965 was Von Braun's hope for a renewed public interest in the future of the Space Program at NASA.

1954-01-01

173

Analysis of Platelet von Willebrand Factor Antigen  

Microsoft Academic Search

Platelet lysates were obtained from suspensions of normal washed platelets by freeze-thawing or Triton X-100 lysis. The resultant platelet lysates contained 0.34 ± 0.15 U\\/109 platelets (n = 8) of von Willebrand factor antigen (vWf:Ag) as determined by radio-electroimmunoassay using a monospecific antibody to vWf:Ag. The vWf:Ag level was higher in platelet lysates prepared from freshly drawn blood than from

Kathy B. Thomas; Barry G. Firkin; Margaret A. Howard

1987-01-01

174

Strongly 1Bounded Von Neumann Algebras  

Microsoft Academic Search

.  Suppose F is a finite tuple of selfadjoint elements in a tracial von Neumann algebra M. For ? > 0, F is ?-bounded if $${\\\\mathbb{P}}^\\\\alpha (F) $${\\\\mathbb{P}}^\\\\alpha$$ is the free packing ?-entropy of F introduced in [J3]. M is said to be strongly 1-bounded if M has a 1-bounded finite tuple of selfadjoint generators F such that there exists an

Kenley Jung

2007-01-01

175

Divisible operators in von Neumann algebras  

Microsoft Academic Search

Relativizing an idea from multiplicity theory, we say that an element of a von Neumann algebra $\\\\mathcal {M}$ is n-divisible if it commutes with a type In<\\/sub> subfactor. We decide the density of the n-divisible operators, for various n, $\\\\mathcal {M}$ , and operator topologies. The most sensitive case is ?-strong density in II1<\\/sub> factors, which is closely related to

David Sherman

2010-01-01

176

Divisible operators in von Neumann algebras  

Microsoft Academic Search

Relativizing an idea from multiplicity theory, we say that an element x of a von Neumann algebra M is n-divisible if (W*(x)' cap M) unitally contains a factor of type I_n. We decide the density of the n-divisible operators, for various n, M, and operator topologies. The most sensitive case is sigma-strong density in II_1 factors, which is closely related

David Sherman

2006-01-01

177

von Willebrand disease and platelet disorders.  

PubMed

The diagnosis and management of bleeding disorders is made difficult by the complexity and variety of disorders, clinical symptoms and bleeding type and severity. von Willebrand disease (VWD) and platelet disorders are disorders of primary haemostasis and together represent the most common inherited bleeding disorders. In this article, we describe the diagnosis of VWD and platelet disorders and the treatment options for VWD. PMID:24762277

Favaloro, E J; Bodó, I; Israels, S J; Brown, S A

2014-05-01

178

Dr. von Braun and Army Ballistics Missile Agency (ABMA) Group  

NASA Technical Reports Server (NTRS)

This photograph of Dr. von Braun, shown here to the left of General Bruce Medaris, was taken in the fall of 1959, immediately prior to Medaris' retirement from the Army. At the time, von Braun and his associates worked for the Army Ballistics Missile Agency in Huntsville, Alabama. Those in the photograph have been identified as Ernst Stuhlinger, Frederick von Saurma, Fritz Mueller, Hermarn Weidner, E.W. Neubert (partially hidden), W.A. Mrazek, Karl Heimburg, Arthur Rudolph, Otto Hoberg, von Braun, Oswald Lange, Medaris, Helmut Hoelzer, Hans Maus, E.D. Geissler, Hans Heuter, and George Constan.

1959-01-01

179

von Willebrand factor in iris vasculature of glaucoma patients  

PubMed Central

Background Previous reports have indicated the role of endothelium disturbances, as expressed by von Willebrand factor (vWF) release, in pathophysiology of glaucoma. The objective of this study was to investigate the vWF expression in iris vasculature of patients with primary open-angle glaucoma (POAG). Material/Methods Immunohistochemistry of vWF expression was performed on cryostat sections of samples collected at the time of peripheral iridectomy and controls collected from dead donors. Results Twenty-seven Caucasians age 66.6±3.7 with 5.8±3.7-year history of treated PAOG and 10 controls age 62.2±1.92 with no history of glaucoma. The percentage of patients who presented normal and up-regulation of vWF phenotype expression differed statistically between examined and control groups: 48% versus 100% (p=0.035, chi-square test with Yates’ correction). Sex, age, glaucoma duration, and visual field quantitative indices had no impact on vWF expression. A significant correlation between mean pre-surgery intraocular pressure and vWF expression was found (Spearman r=0.42, p=0.03). Conclusions Considering the results, it may be suggested that vWF is actively involved in the pathophysiology of glaucoma.

Rokicki, Wojciech; Zaba, Malgorzata; Mrukwa-Kominek, Ewa; Wygledowska-Promienska, Dorota; Brzozowa, Marlena; Reichman-Warmusz, Edyta; Wojnicz, Romuald

2014-01-01

180

von Willebrand factor in iris vasculature of glaucoma patients.  

PubMed

Background Previous reports have indicated the role of endothelium disturbances, as expressed by von Willebrand factor (vWF) release, in pathophysiology of glaucoma. The objective of this study was to investigate the vWF expression in iris vasculature of patients with primary open-angle glaucoma (POAG). Material and Methods Immunohistochemistry of vWF expression was performed on cryostat sections of samples collected at the time of peripheral iridectomy and controls collected from dead donors. Results Twenty-seven Caucasians age 66.6±3.7 with 5.8±3.7-year history of treated PAOG and 10 controls age 62.2±1.92 with no history of glaucoma. The percentage of patients who presented normal and up-regulation of vWF phenotype expression differed statistically between examined and control groups: 48% versus 100% (p=0.035, chi-square test with Yates' correction). Sex, age, glaucoma duration, and visual field quantitative indices had no impact on vWF expression. A significant correlation between mean pre-surgery intraocular pressure and vWF expression was found (Spearman r=0.42, p=0.03). Conclusions Considering the results, it may be suggested that vWF is actively involved in the pathophysiology of glaucoma. PMID:24954072

Rokicki, Wojciech; Zaba, Ma?gorzata; Mrukwa-Kominek, Ewa; Wygl?dowska-Promie?ska, Dorota; Brzozowa, Marlena; Reichman-Warmusz, Edyta; Wojnicz, Romuald

2014-01-01

181

Ocular clusterin expression in von Hippel-Lindau disease  

PubMed Central

Purpose Clusterin is a multifunctional glycoprotein. Its mRNA is ubiquitously expressed, with high levels in von Hippel-Lindau (VHL) target organs such as the brain, liver, kidney, and adrenal medulla. Decreased clusterin secretion has been reported in renal cell carcinoma associated with VHL disease. The purpose of this study was to investigate ocular clusterin expression in VHL disease. Methods This retrospective case series included nine eyes with retinal hemangioblastoma/hemangioma associated with VHL disease, one eye from a patient with a history of VHL disease and central nervous system hemangioblastomas but without ocular lesions, one surgically-excised optic nerve with optic nerve hemangioblastoma/hemangioma, and three normal control eyes. Ocular specimens were evaluated by routine histology, immunohistochemistry for clusterin expression, and molecular detection of clusterin transcripts within ocular VHL hemangioblastomas compared with normal tissue from the same eye using microdissection and quantitative real-time PCR. Results All retinal hemangioblastoma were composed of typical VHL tumor cells admixed with small vascular channels as well as glial cells. Marked decrease of clusterin immunoreactivity was detected in all retinal hemangioblastoma and the optic nerve hemangioblastoma, whereas positive clusterin reactivity of the vascular and glial components was similar to that of normal retina. Quantitative real-time PCR analysis confirmed the decrease of clusterin mRNA in the VHL associated retinal hemangioblastoma and optic nerve hemangioblastoma in five cases. Conclusions Clusterin shows possible important functions in tumor suppression by the VHL gene product (pVHL) and the potential to be a novel biomarker in retinal hemangioblastoma associated VHL disease. Further investigation of clusterin may provide better understanding of retinal hemangioblastoma associated with VHL disease.

Zhou, Min; Shen, Defen; Head, James E.; Chew, Emily Y.; Chevez-Barrios, Patricia; Richard Green, W.; Chan, Chi-Chao

2007-01-01

182

Quantitative thallium imaging  

Microsoft Academic Search

There has been much recent interest in quantitative interpretation of 201thallium myocardial imaging. Quantitative analysis can be used as an aid in the more accurate interpretation of myocardial scans. Quantitative analysis is essential to extract information about the kinetics of thallium redistribution. This article briefly reviews the mechanism of uptake and redistribution of 201thallium in the heart and the effect

M. Charron; J. A. Parker

1989-01-01

183

On the Determination of Small Sulfur Amounts in Silver, Copper, Gold and Platinum ueber die Bestimmung Kleiner Schwefelgehalte in Silber, Kupfer, Gold und Platin.  

National Technical Information Service (NTIS)

A hot extraction procedure and a solvent distillation method are reported for the quantitative determination of sulfur traces in silver, copper, gold and platinum. The first method extracts sulfur from the heated silver as hydrogen sulfide, through a hydr...

A. V. Kameke

1974-01-01

184

Assay of the von Willebrand factor (VWF) propeptide to identify patients with type 1 von Willebrand disease with decreased VWF survival  

PubMed Central

Type 1 von Willebrand disease (VWD) is characterized by a partial quantitative deficiency of von Willebrand factor (VWF). Few VWF gene mutations have been identified that cause dominant type 1 VWD. The decreased survival of VWF in plasma has recently been identified as a novel mechanism for type 1 VWD. We report 4 families with moderately severe type 1 VWD characterized by low plasma VWF:Ag and FVIII:C levels, proportionately low VWF:RCo, and dominant inheritance. A decreased survival of VWF in affected individuals was identified with VWF half-lives of 1 to 3 hours, whereas the half-life of VWF propeptide (VWFpp) was normal. DNA sequencing revealed a single (heterozygous) VWF mutation in affected individuals, S2179F in 2 families, and W1144G in 2 families, neither of which has been previously reported. We show that the ratio of steady-state plasma VWFpp to VWF:Ag can be used to identify patients with a shortened VWF half-life. An increased ratio distinguished affected from unaffected individuals in all families. A significantly increased VWFpp/VWF:Ag ratio together with reduced VWF:Ag may indicate the presence of a true genetic defect and decreased VWF survival phenotype. This phenotype may require an altered clinical therapeutic approach, and we propose to refer to this phenotype as type-1C VWD.

Haberichter, Sandra L.; Balistreri, Michael; Christopherson, Pamela; Morateck, Patricia; Gavazova, Stefana; Bellissimo, Daniel B.; Manco-Johnson, Marilyn J.; Gill, Joan Cox; Montgomery, Robert R.

2006-01-01

185

Über die Bindung von Kalzium in Ei und Larve von Paracentrotus lividus  

Microsoft Academic Search

Zusammenfassung Bei der Befruchtung der Eier vonParacentrotus lividus (Roscoff) werden ins Seewasser Substanzen abgegeben, die mit Oxalat in schwach alkalischer Lösung (Seewasser) fällbar sind. In Anschluß an frühere Befunde wird vermutet, daß wenigstens ein Teil dieser Fällung aus Kalziumoxalat besteht, und daß demzufolge Ca bei der Befruchtung ins Seewasser abgegeben wird. Pro ccm Eier beträgt diese Veränderung 0,20 mg Ca.

Åke Örström; Margot Örström

1941-01-01

186

Anesthesia and von Hippel-Lindau disease associated with pheochromocytoma  

Microsoft Academic Search

Von Hippel-Lindau disease is char­ acterized by the association of retinal angiomatosis with cerebellar hemangiomas. But the disease may manifest a variety of distinct lesions, more than 25 of which have been identified. Von Rippel-Lindau disease described here was associated with pheochromocytoma. We report on the rare case of anesthesia and discuss the potential anesthetic problems. Case Report The patient,

Yuko Hoshino; Hidefumi Obara; Katsuya Mikawa; Seizo Iwai

1987-01-01

187

When is the economy monocentric?: von Thünen and Chamberlin unified  

Microsoft Academic Search

Since The Isolated State by von Thünen, countless versions of the von Thünen model have appeared. It seems, however, that a fundamental question remains unanswered: Why should all manufacturing goods be produced in a single town? In this paper we develop a monopolistic competition model of an ‘isolated state’, and investigate the answer to this question. Since the answer to

Masahisa Fujita; Paul Krugman

1995-01-01

188

Eine FPAA-Architektur zur rekonfigurierbaren Instantiierung von zeitkontinuierlichen Analogfiltern  

Microsoft Academic Search

Im Folgenden wird eine neue Methodik von FPAAs (Field Programmable Analog Arrays) gezeigt, die speziell für die Instantiierung von zeitkontinuierlichen (continuous-time, CT) Analogfiltern in Hardware entwickelt wurde. Die Chiptopologie beinhaltet 17 digital konfigurierbare analoge Blöcke (configurable analog blocks, CABs), die durch ein hexagonales Netzwerk miteinander verbunden sind. Jeder CAB ist aus einstellbaren Gm-C Integratoren aufgebaut, welche das analoge Signal sowohl

J. Becker; Y. Manoli

2005-01-01

189

Kreislaufwirkungen von g-Strophanthin am normalen und herzinsuffizienten Meerschweinchen  

Microsoft Academic Search

An Meerschweinchen in Urethan- oder Veronal-Narkose wurden die Kreislaufwirkungen einer Injektion oder Infusion von g-Strophanthin untersucht. Durch Zugabe von Veronal gelang es, den Blutdruck unter 40 mm Hg zu senken und damit eine reproduzierbare Ausgangslage zu schaffen. Durch Verstärkung einer Urethan-Narkose wurde der Blutdruck nicht beeinflußt.

W. Schaumann

1964-01-01

190

Vergleichende Bewertung von Faschinen und Flechtzäunen zur Böschungssicherung im Verkehrswegebau  

Microsoft Academic Search

Zu begrünende Böschungen entlang von Verkehrswegen werden häufig mit Oberboden angedeckt. Solche Bodenandeckungen sind bei den üblichen Böschungsneigungen von 1: 1,5 bis 1: 2 stark erosions- und rutschungsgefährdet. Durch das Aufrauhen des Untergrundes und die Herstellung einer guten Verzahnung zwischen Rohböschung und anzudeckendem Oberboden kann die Rutschungsgefahr verringert werden. In der Regel sind jedoch weitergehende ingenieurbiologische Schutzmaßnahmen wie der Bau

Egon Stalljann; Stephan Bloemer

2008-01-01

191

Virtualized Optical Network (VON) for Future Internet and Applications  

NASA Astrophysics Data System (ADS)

A virtualized optical network (VON) is proposed as a key to implementing increased agility and flexibility into the future Internet and applications by providing any-to-any connectivity with the appropriate optical bandwidth at the appropriate time. The VON is enabled by introducing optical transparentization and optical fine granular grooming based on optical orthogonal frequency division multiplexing.

Jinno, Masahiko; Tsukishima, Yukio; Takara, Hidehiko; Kozicki, Bartlomiej; Sone, Yoshiaki; Sakano, Toshikazu

192

Software Techniques for Non-Von Neumann Architectures.  

National Technical Information Service (NTIS)

This report examines the use of non-sequential (Non-von Neumann) technology for the support of command and control applications. It has become apparent that the utilization of traditional von-Neumann computers is insufficient of many applications. The uti...

C. Lightfoot D. Sakal J. Shelton R. Duncan T. Busse

1990-01-01

193

Victor or Villain? Wernher von Braun and the Space Race  

ERIC Educational Resources Information Center

Set during the Cold War and space race, this historical role-play focuses on Wernher von Braun's involvement in and culpability for the use of slave laborers to produce V-2 rockets for Nazi Germany. Students will grapple with two central questions. Should von Braun have been allowed to emigrate to the United States given his affiliation with the…

O'Brien, Jason L.; Sears, Christine E.

2011-01-01

194

Victor or Villain? Wernher von Braun and the Space Race  

Microsoft Academic Search

Set during the Cold War and space race, this historical role-play focuses on Wernher von Braun's involvement in and culpability for the use of slave laborers to produce V-2 rockets for Nazi Germany. Students will grapple with two central questions. Should von Braun have been allowed to emigrate to the United States given his affiliation with the Nazis and use

Jason L. O’Brien; Christine E. Sears

2011-01-01

195

[Dermatological aspects of Hildegard von Bingen's work].  

PubMed

In many ways Hildegard von Bingen was honoured in 1979 in memory of the 800th anniversary of her death. Hildegard was not only the mystical visionary and prophetess of the middle ages, she was for her time also a practical thinking physician with an enormous scientific knowledge. In her books "physica" and "causae et curae" numerous clinical pictures of dermatological diseases are described as well as therapeutical advices given which offer a wide insight into the knowledge of skin diseases of this period of monastery medicine. PMID:6995404

Bork, K

1980-07-01

196

Oral hamartomas with von Recklinghausen disease  

PubMed Central

Neurofibromatosis is a genetically-inherited disorder of the nervous system that primarily affects the development and growth of neural (nerve) cell tissues and also causes cafe-au-lait spots on the skin, dysplastic abnormalities of the skin, nervous system, bones, endocrine organs and blood vessels. The two major classifications are NF-1, a generalized form, is the commonest and affects peripheral nerve tissues and NF-2, a rare central form, affects the central nervous system. An unusual finding of oral hamartomas may occur as part of NF-1 and here we presented one such rare case of oral hamartomas in a patient with Von-Recklinghausen's disease.

Kumar, C Anand; Reddy, RC Jagat; Gupta, Siddarth; Laller, Sanjeev

2011-01-01

197

Key contributors: Ernst von Glasersfeld's radical constructivism  

NASA Astrophysics Data System (ADS)

This article reviews the significance of the contributions of Ernst von Glasersfeld to research in science education, especially through his theoretical contributions on radical constructivism. As a field shaper, Glasersfeld's subversive ideas catalyzed debate in the science education community and fuelled transformation of many facets including research methods, ways of thinking about teaching and learning, curriculum, and science teacher education. Perturbations emanating from the debates on constructivism forged new pathways that led to the development and use of many of the sociocultural frameworks employed by authors in Cultural Studies of Science Education.

Tobin, Kenneth

2007-07-01

198

Eine Systematik für Entstehungsmechanismen von Tinnitus  

Microsoft Academic Search

  \\u000a In Anbetracht der großen Komplexität und Vielfalt des Problems Tinnitus ist eine Systematik hilfreich. Während Therapie–und\\u000a Ursachenforschung durchaus Fortschritte (z.B. Retraining–Therapie) machen, können nämlich die Entstehungsmechanismen mit einer\\u000a systematischen Einteilung übersichtlich dargestellt werden. Die Systematik eignet sich zur wissenschaftlichen Verständigung,\\u000a zur Vermittlung von Tinnitusmodellen an den Patienten im Rahmen des Tinnitus–Counselling sowie als Basis für eine rationale\\u000a Tinnitusdiagnostik und

H.-P. Zenner

1998-01-01

199

Approximating incompatible von Neumann measurements simultaneously  

SciTech Connect

We study the problem of performing orthogonal qubit measurements simultaneously. Since these measurements are incompatible, one has to accept additional imprecision. An optimal joint measurement is the one with the least possible imprecision. All earlier considerations of this problem have concerned only joint measurability of observables, while in this work we also take into account conditional state transformations (i.e., instruments). We characterize the optimal joint instrument for two orthogonal von Neumann instruments as being the Lueders instrument of the optimal joint observable.

Heinosaari, Teiko [Niels Bohr Institute, Blegdamsvej 17, DK-2100 Copenhagen (Denmark); Jivulescu, Maria Anastasia [Niels Bohr Institute, Blegdamsvej 17, DK-2100 Copenhagen (Denmark); Department of Mathematics, University Politehnica Timisoara, P-ta Victoriei Nr. 2, R-300006 Timisoara (Romania); Reitzner, Daniel [Institute of Physics, Slovak Academy of Sciences, Dubravska cesta 9, 845 11 Bratislava (Slovakia); Ziman, Mario [Institute of Physics, Slovak Academy of Sciences, Dubravska cesta 9, 845 11 Bratislava (Slovakia); Faculty of Informatics, Masaryk University, Botanicka 68a, Brno (Czech Republic)

2010-09-15

200

A robust von Neumann minimax theorem for zero-sum games under bounded payoff uncertainty  

Microsoft Academic Search

The celebrated von Neumann minimax theorem is a fundamental theorem in two-person zero-sum games. In this paper, we present a generalization of the von Neumann minimax theorem, called robust von Neumann minimax theorem, in the face of data uncertainty in the payoff matrix via robust optimization approach. We establish that the robust von Neumann minimax theorem is guaranteed for various

V. Jeyakumar; G. Y. Li; G. M. Lee

2011-01-01

201

Treatment of patients with von Willebrand disease  

PubMed Central

Von Willebrand disease (vWD) is the most common hereditary bleeding disorder. The aim of therapy is to correct the dual hemostatic defect, due to defective platelet adhesion-aggregation and abnormal coagulation due to Factor VIII (FVIII) deficiency. The choice of treatment depends on a number of factors, including the severity of the bleed, the procedure planned, the subtype and severity of the disease and the age and morbidity of the patient. Desmopressin (DDAVP) is the treatment of choice for type 1 vWD as it increases endogenous release of FVIII and von Willebrand factor (vWF) and is also used in some subtypes of type 2 vWD. In those patients in whom DDAVP is ineffective or contraindicated, levels can be restored by infusing vWF:FVIII concentrates. The role of antifibrinolytic treatment is an important adjunct to replacement therapy during minor or major surgery involving mucosal surfaces. The dosing and timing of vWF:FVIII concentrates is important depending on the nature of the surgical procedure. The role of secondary prophylaxis needs to be further defined.

Tuohy, Emma; Litt, Emma; Alikhan, Raza

2011-01-01

202

Approximate von Neumann entropy for directed graphs  

NASA Astrophysics Data System (ADS)

In this paper, we develop an entropy measure for assessing the structural complexity of directed graphs. Although there are many existing alternative measures for quantifying the structural properties of undirected graphs, there are relatively few corresponding measures for directed graphs. To fill this gap in the literature, we explore an alternative technique that is applicable to directed graphs. We commence by using Chung's generalization of the Laplacian of a directed graph to extend the computation of von Neumann entropy from undirected to directed graphs. We provide a simplified form of the entropy which can be expressed in terms of simple node in-degree and out-degree statistics. Moreover, we find approximate forms of the von Neumann entropy that apply to both weakly and strongly directed graphs, and that can be used to characterize network structure. We illustrate the usefulness of these simplified entropy forms defined in this paper on both artificial and real-world data sets, including structures from protein databases and high energy physics theory citation networks.

Ye, Cheng; Wilson, Richard C.; Comin, César H.; Costa, Luciano da F.; Hancock, Edwin R.

2014-05-01

203

Translational Medicine Advances in von Willebrand Disease  

PubMed Central

Following the recognition of von Willebrand disease (VWD) in 1926 and the cloning of the gene for von Willebrand factor (VWF) in 1985, significant advances have been made in our fundamental knowledge of both the disease and the protein. Some of this new knowledge has also begun to impact the clinical management of VWD. First, the progressive increase in our understanding of the molecular genetic basis of VWD has resulted in rational applications of molecular testing to complement the current range of phenotypic tests for VWD. These molecular genetic strategies are most effectively directed at the prenatal diagnosis of type 3 VWD and confirmatory testing for types 2B and 2N disease. In contrast, the use of molecular testing to clarify the diagnosis of type 1 VWD is of marginal benefit, at best. In terms of VWD therapies, a new recombinant VWF concentrate has recently completed successful clinical trials and is now awaiting more widespread application. There have even been some pre-clinical successes with VWF gene transfer although the clinical rationale for this therapeutic strategy needs careful consideration. Much more remains to be learnt about the biology of VWF and further translational advances for the enhancement of VWD care will inevitably be realized.

Lillicrap, David

2014-01-01

204

Von Willebrand disease: pathogenesis and management.  

PubMed

Recent studies have suggested a unifying pathophysiological concept to explain the underlying defects of von Willebrand factor (VWF) causing von Willebrand disease (VWD) and have highlighted the relevance of simple VWF related activities in producing a useful diagnosis. A standardized bleeding history condensed into a final bleeding score and few widely available laboratory tests, such as VWF ristocetin cofactor activity, VWF antigen and factor VIII (FVIII), in the index case and in his/her relatives are of critical importance. Ristocetin-induced platelet aggregation (RIPA) should also be tested. Trial with desmopressin should be carried out in patients, except those with virtual absence of VWF or with increased RIPA. Desmopressin should be used in all responsive patients as first choice. Substitutive treatment with VWF/FVIII containing products should be used in unresponsive patients, in those with heightened response to desmopressin or in those undergoing interventions requiring good hemostasis for more than 3-5 days. Special consideration should be deserved to the treatment of menorrhagia and parturition. PMID:23452742

Rodeghiero, Francesco

2013-01-01

205

Ein Demonstrationsversuch zur Hyperfeinaufspaltung von Atomen  

NASA Astrophysics Data System (ADS)

Der Nachweis der laserinduzierten Resonanzfluoreszenz an einem thermischen Atomstrahl erlaubt auf einfache Weise die Beobachtung der Hyperfeinaufspaltung im Grund- und angeregten Zustand von Natrium. Ein für Demonstrationen geeigneter Versuch kann, neben dem Atomstrahl selbst, die Wirkung von Elektronen- und Kernspin im Hörsaal vorführen. Das benötigte Laserlicht wird hierbei über ein Lichtleiterkabel vom Labor in den Hörsaal geführt. Der Versuch kann auch zur Demonstration des optischen Pumpens und durch Anlegen eines Magnetfeldes in der Beobachtungsregion zur Demonstration des Zeeman-Effektes benutzt werden.Translated AbstractAn Experiment to Demonstrate the Hyperfine Splitting of Atoms in a Lecture HallThe detection of laser induced fluorescence from a thermal atomic beam allows in a simple way for the observation of the hyperfine splitting of ground and excited Na-atoms. A suitable experimental setup is able to show in a lecture hall not only the atomic beam itself but also the consequences of electron and nuclear spin. The laser light used is transmitted from the laser in the laboratory into the lecture hall by a fiber glass cable. The experiment is able to show also the effects of optical pumping and, if additionally an external magnetic field is applied to the observation region, the Zeeman effect.

Schmitzer, A.; Bechtel, H. H.; Fick, D.

206

Modern quantitative schlieren techniques  

Microsoft Academic Search

Schlieren optical techniques have traditionally been used to qualitatively visualize refractive flowfields in transparent media. Modern schlieren optics, however, are increasingly focused on obtaining quantitative information such as temperature and density fields in a flow -- once the sole purview of interferometry -- without the need for coherent illumination. Quantitative data are obtained from schlieren images by integrating the measured

Michael Hargather; Gary Settles

2010-01-01

207

A constrained von Mises distribution to describe fiber organization in thin soft tissues.  

PubMed

The semi-circular von Mises distribution is widely used to describe the unimodal planar organization of fibers in thin soft tissues. However, it cannot accurately describe the isotropic subpopulation of fibers present in such tissues, and therefore an improved mathematical description is needed. We present a modified distribution, formed as a weighted mixture of the semi-circular uniform distribution and the semi-circular von Mises distribution. It is described by three parameters: ?, which weights the contribution from each mixture component; k, the fiber concentration factor; and ? ( p ), the preferred fiber orientation. This distribution was used to fit data obtained by small-angle light scattering experiments from various thin soft tissues. Initial use showed that satisfactory fits of fiber distributions could be obtained (error generally < 1%), but at the cost of non-physically meaningful values of k and ?. To address this issue, an empirical constraint between the parameters k and ? was introduced, resulting in a constrained 2-parameter fiber distribution. Compared to the 3-parameter distribution, the constrained 2-parameter distribution fits experimental data well (error generally < 2%) and had the advantage of producing physically meaningful parameter values. In addition, the constrained 2-parameter approach was more robust to experimental noise. The constrained 2-parameter fiber distribution can replace the semi-circular von Mises distribution to describe unimodal planar organization of fibers in thin soft tissues. Inclusion of such a function in constitutive models for finite element simulations should provide better quantitative estimates of soft tissue biomechanics under normal and pathological conditions. PMID:21739088

Gouget, Cecile L M; Girard, Michael J; Ethier, C Ross

2012-03-01

208

The diagnosis and treatment of von Willebrand disease in children  

PubMed Central

von Willebrand disease is the most common bleeding disorder seen in children and it affects approximately 1% of the population. Because the bleeding symptoms in von Willebrand disease are generally mild, the diagnosis is often delayed. Prompt diagnosis and management can help to avoid potentially life-threatening bleeding events and unnecessary exposure to blood products. In this review, the various types of von Willebrand disease are outlined, the difficulties in diagnosis are discussed and the therapeutic approach to this common disorder is described.

Klaassen, Robert J; Halton, Jacqueline M

2002-01-01

209

Von Neumann's growth model: Statistical mechanics and biological applications  

NASA Astrophysics Data System (ADS)

We review recent work on the statistical mechanics of Von Neumann's growth model and discuss its application to cellular metabolic networks. In this context, we present a detailed analysis of the physiological scenario underlying optimality à la Von Neumann in the metabolism of the bacterium E. coli, showing that optimal solutions are characterized by a considerable microscopic flexibility accompanied by a robust emergent picture for the key physiological functions. This suggests that the ideas behind optimal economic growth in Von Neumann's model can be helpful in uncovering functional organization principles of cell energetics.

De Martino, A.; Marinari, E.; Romualdi, A.

2012-09-01

210

Automatische Detektion von Lymphknoten in CT-Datensätzen des Halses  

NASA Astrophysics Data System (ADS)

Zur computergestützten, präoperativen Planung von HalsLymphknoten-Ausräumungen (Neck Dissections) ist eine Detektion aller vergrößerten Lymphknoten wünschenswert. Diese erfolgt zur Zeit ausschließlich manuell durch einen Radiologen und ist ein zeitaufwändiger und fehleranfälliger Prozess. Wir präsentieren ein Verfahren zur automatischen Detektion von Lymphknoten in CT-Datensätzen des Halses mit Hilfe dreidimensionaler Stabiler Feder-Masse-Modelle (SMSMs). Die Detektion erfolgt durch Abgleich aller in Frage kommenden Datensatzbereiche mit einem deformierbaren 3D-Modell des Lymphknotens, welches Form, Grauwerte und Kanteninformation gleichermaßen modelliert. Das Verfahren wurde an 29 vergrößerten (> 8 mm) Lymphknoten eines klinischen CT-Datensatzes evaluiert und zeigte daran eine Detektionsrate von 100 % bei 9 falsch-positiven Kandidaten.

Dornheim, Lars; Dornheim, Jana

211

Botulinum-Toxin-A in der Behandlung von Phantomschmerzen  

Microsoft Academic Search

Zusammenfassung  \\u000a Bei einem letztlich nicht geklärten Pathomechanismus stellt die Behandlung von Phantom-und Stumpfschmerzen nach wie vor eine\\u000a schwierige Aufgabe dar.Eine Behandlung mit Botulinum-Toxin wurde bisher nicht beschrieben.\\u000a \\u000a \\u000a \\u000a Wir berichten über die erfolgreiche Behandlung von 4 Patienten mit Phantomschmerzen der unteren Extremität seit mehr als 3\\u000a Jahren mit der Injektion von je 25 IE Botulin-Toxin-A in 4 Triggerpunkte der Stumpfmuskulatur. Drei

U. Kern; C. Martin; S. Scheicher; H. Müller

2003-01-01

212

The two Vons: the World War I secret government investigation of Erich von Stroheim  

Microsoft Academic Search

:Research in U.S. government archives concerning World War I-era German espionage activities in the United States reveals a number of previously unknown surveillance files regarding film actor and director Erich von Stroheim. The essay describes the process through which these otherwise un-indexed files were discovered and reprints several of the key documents. Evidence indicates that Military Intelligence suspected a link

Elliot Einzig Porter

2010-01-01

213

The two Vons: the World War I secret government investigation of Erich von Stroheim  

Microsoft Academic Search

Research in U.S. government archives concerning World War I-era German espionage activities in the United States reveals a number of previously unknown surveillance files regarding film actor and director Erich von Stroheim. The essay describes the process through which these otherwise un-indexed files were discovered and reprints several of the key documents. Evidence indicates that Military Intelligence suspected a link

Elliot Einzig Porter

2010-01-01

214

Isotopengeochemische Untersuchungen an Fraktionen von geloestem organischem Kohlenstoff (DOC) zur Bestimmung der Herkunft und Evolution des DOC im Hinblick auf die Datierung von Grundwasser. (Isotope-geochemical studies on fractions of dissolved organic carbon (DOC) for determining the origin and evolution of DOC for purposes of groundwater dating).  

National Technical Information Service (NTIS)

The laboratory work consisted in developing and testing methods of extraction and enrichment of individual high-purity DOC fractions (fulvic acids, humic acids, and low-molecular substances) with the aim of preparing large quantities of groundwaters (> 10...

S. Geyer

1994-01-01

215

Evidence-based recommendations on the treatment of von Willebrand disease in Italy  

PubMed Central

Background von Willebrand disease (VWD) is the most common hereditary bleeding disorder affecting both males and females. It arises from quantitative or qualitative defects of von Willebrand factor (VWF) and causes bleeding of mucous membranes and soft tissues. The aim of treatment is to correct the dual defect of haemostasis caused by the abnormal/reduced VWF and the concomitant deficiency of factor VIII (FVIII). Material and methods This document contains evidence-based recommendations for the management of VWD compiled by AICE (the Italian Association of Haemophilia Centres). All the evidence supporting these recommendations are based on non-randomised comparative studies or case series, because randomised controlled clinical trials or meta-analyses are not available for this disease. Results and conclusions Desmopressin (DDAVP) is the treatment of choice for patients with type 1 VWD with FVIII and VWF levels of 10 U/dL or more, while VWF/FVIII concentrates are indicated for those who are unresponsive or insufficiently responsive to DDAVP (severe type 1, type 2 and 3 VWD). VWF concentrates devoid of FVIII, not yet licensed in Italy, may be considered for short-term prophylaxis in elective surgery or for long-term secondary prophylaxis.

Mannucci, Pier Mannuccio; Franchini, Massimo; Castaman, Giancarlo; Federici, Augusto B.

2009-01-01

216

Laboratory aspects of von Willebrand disease: test repertoire and options for activity assays and genetic analysis.  

PubMed

The deficiency or abnormal function of von Willebrand factor (VWF) causes von Willebrand disease (VWD), the most frequent inherited bleeding disorder. The laboratory diagnosis of VWD can be difficult as the disease is heterogeneous and an array of assays is required to describe the phenotype. Basic classification of quantitative (type 1 and 3) and qualitative (type 2) VWD variants requires determination of VWF antigenic (VWF:Ag) levels and assaying of VWF ristocetin cofactor (VWF:RCo) activity, determining the capacity of VWF to interact with the platelet GPIb-receptor. Knowing the VWF:RCo activity is essential for identifying, subtyping and monitoring VWD, but the assay is poorly standardized and many protocols do not fulfil the clinical need in all situations. This has led to the development of novel activity assays, independent of ristocetin, with enhanced assay characteristics. Results from the first independent clinical evaluations are promising, showing that they are reliable and suitable for VWD diagnosis. The qualitative type 2 VWF deficiency can be further divided into four different subtypes (A, B, M and N) using specific assays that explore other activities or the size distribution of VWF multimers. These methods are discussed herein. However, in a number of patients it may be difficult to correctly classify the VWD phenotype and genetic analysis may provide the best option to clarify the disorder, through mutation identification. PMID:24762278

Castaman, G; Hillarp, A; Goodeve, A

2014-05-01

217

33. HISTORIC VIEW OF WERNHER VON BRAUN LOOKS THROUGH THE ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

33. HISTORIC VIEW OF WERNHER VON BRAUN LOOKS THROUGH THE PERISCOPE FROM THE CONTROL ROOM AT TEST STAND NO. 1, PEENEMUENDE. - Marshall Space Flight Center, Redstone Rocket (Missile) Test Stand, Dodd Road, Huntsville, Madison County, AL

218

Dr. von Braun tours the North American Aviation  

NASA Technical Reports Server (NTRS)

Dr. Wernher von Braun, Director of the Marshall Space Flight Center (MSFC), during his tour of the Space Information Division of North American Aviation (NAA) in Downey, California, where the Saturn SII stage was developed.

1962-01-01

219

Dr. von Braun Tours the North American Aviation  

NASA Technical Reports Server (NTRS)

Dr. Wernher von Braun, Director of the Marshall Space Flight Center (MSFC), during his tour of the Space information Division of North American Aviation (NAA) in Downey, California, where the Saturn SII stage was developed.

1962-01-01

220

Über die galletreibende Wirkung von Curcuma domestica (Temoe Lawak)  

Microsoft Academic Search

Zusammenfassung Die galletreibende Wirkung des Rhizoms von Curcuma domestica (Temoe Lawak) wurde in Versuchen an Ratten geprüft. Das in dem ätherischen Öl des Rhizoms enthaltene p-Tolyl-methyl-carbinol wurde als wirksamer Bestandteil ermittelt.

F. Grabe

1934-01-01

221

Can a Quantum Computer Run the von Neumann Architecture?  

NASA Astrophysics Data System (ADS)

At the core of nearly every modern computer is a central processing unit running the von Neumann architecture. This computer architecture gives computationally universal machines, and non-trivial control structures arise naturally, leading to high-level programming constructs.

Hines, P.

222

Dr. Wernher Von Braun examines a ruby crystal.  

NASA Technical Reports Server (NTRS)

Dr. Wernher Von Braun (right), director of the Marshall Space Flight Center, and Dr. Eberhard Rees (left), deputy director, technical, examine a ruby crystal used in laser experiments in the Marshall Center's Space Sciences Laboratory.

1999-01-01

223

Fletcher and von Braun at Apollo 15 launch  

NASA Technical Reports Server (NTRS)

Recently appointed NASA Administrator Dr. James C. Fletcher, left, and Dr. Wernher von Braun, Deputy Associate Administrator for Planning, monitor Apollo 15 prelaunch activities in Firing Room 1 of the Launch Control Center and the Kennedy Space Center, Florida.

1971-01-01

224

A New Variant of Type II von Willebrand Disease With Aberrant Multimeric Structure of Plasma but Not Platelet von Willebrand Factor (Type hF)  

Microsoft Academic Search

A patient with a lifelong bleeding disorder was diagnosed as having Type II von Willebrand disease. The larger multimers of von Willebrand factor were absent from her plasma but present in platelets. A high-resolution electro- phoretic technique was used to study the complex struc- ture of individual von Willebrand factor multimers. In normal plasma. each multimer could be resolved into

Pier Mannuccio Mannucci; Rossana Lombardi; Augusto B. Federici; Judith A. Dent; Theodore S. Zimmerman; Zaverio M. Ruggeri

1986-01-01

225

Von Donuts und Zucker: Mit Neutronen biologische Makromoleküle erforschen  

NASA Astrophysics Data System (ADS)

Für die Erforschung von Biomolekülen bieten Neutronen einzigartige Eigenschaften. Vor allem ihre unterschiedliche Wechselwirkung mit dem natürlichen Wasserstoff und seinem schweren Isotop Deuterium ermöglicht tiefe Einblicke in Struktur, Funktion und Dynamik von Proteinen, Nukleinsäuren und Biomembranen. Bei vielen Fragestellungen zur Strukturaufklärung gibt es kaum oder keine Alternative zum Neutron. Das Institut Laue-Langevin trägt Bahnbrechendes zum Erfolg der Neutronen-Methoden in der Biologie bei.

May, Roland P.

2003-05-01

226

Zur natürlichen Dauerhaftigkeit von Kempas und Keruing gegenüber holzzerstörenden Pilzen  

Microsoft Academic Search

Zusammenfassung  Die natrliche Dauerhaftigkeit von je 5 Schwellenabschnitten der malaysischen Handelshlzer Kempas (Koompassia malaccensis) und Keruing (Dipterocarpus spp.) gegenber Braun-, Wei- und Moderfulepilzen (Daedalea quercina, Polystictus versicolor, Chaetomium globosum, Paecilomyces spec.) wurde im 4monatigen Kolleschalenversuch geprft. Hierbei ergaben sich gesicherte Unterschiede in Abhngigkeit von\\u000a der Pilzart und der Vorbehandlung des Holzes. Im allgemeinen besa die Holzarten eine geringe bis mittlere Dauerhaftigkeit.

Günther Seehann

1973-01-01

227

Acquired von Willebrand Syndrome: Its Pathophysiology, Laboratory Features and Management  

Microsoft Academic Search

Acquired von Willebrand syndrome is a bleeding disorder associated with various underlying diseases. The clinical manifestations are similar to congenital von Willebrand disease. Diagnosis is mainly confirmed by decrease of ristocetin cofactor activity (vWF:RCo) and collagen binding activity (vWF:CBA) and by vWF multimeric analysis usually with selective loss of large multimers. Various pathogenic mechanisms have been proposed, including development of

Hiroshi Mohri

2003-01-01

228

Molecular Genetics of Type 2 von Willebrand Disease  

Microsoft Academic Search

Type 2 von Willebrand disease (VWD) is characterized by a wide heterogeneity of functional and structural defects. These abnormalities\\u000a cause either defective von Willebrand factor (VWF)-dependent platelet function in subtypes 2A, 2B, and 2M or defective VWF-factor\\u000a VIII (FVIII) binding in subtype 2N. The diagnoses of types 2A, 2B, and 2M VWD may be guided by the observation of disproportionately

Edith Fressinaud; Claudine Mazurier; Dominique Meyer

2002-01-01

229

Autosomal Dominant von Willebrand Disease Type 2M  

Microsoft Academic Search

von Willebrand disease (VWD) type 2M is a distinct entity and clearly differs from type 1. The genotype-phenotype correlation for cases with ristocetin cofactor activity (RCo)\\/antigen (Ag) ratios <0.60 is clear, whereas the von Willebrand factor (VWF):collagen binding (CB)\\/VWF:Ag ratio is normal in VWD 2M. Typical laboratory features of VWD type 2 M are decreased ristocetin-induced platelet aggregation in the

Cedric Hermans; Javier Batlle

2009-01-01

230

Ortung von mobilen Geräten für die Realisierung lokationsbasierter Diensten  

Microsoft Academic Search

Die Entwicklung im Sektor von mobilen Endgeraten geht eindeutig in die Richtung, immer kompaktere Gerate mit immer mehr Funktionalitat anzubieten. Schon heute k¤ onnen z.B. Laptops oder sogar PalmTops mit GPS-Kontrollern kombiniert wer- den. Die somit verfugbaren genauen Positionsinformationen erm¤ oglichen die Realisie- rung von unterschiedlichsten lokationsbasierten Diensten. Ziel des in diesem Papier vorgestellten Projektes ist es, die M¤ oglichkeiten

Felix Alcala; Arne Frenkel; Johannes L; Hagen Hopfner

2003-01-01

231

Physik gestern und heute Von der Metallstange zum Hochenergielaser  

NASA Astrophysics Data System (ADS)

Im Mai 1752 wurde in Marly bei Paris auf Anregung des amerikanischen Forschers und Politikers Benjamin Franklin erstmals die elektrische Natur des Blitzes nachgewiesen. Damals beschrieb Franklin auch eine technische Vorrichtung, die als Schutz von Gebäuden vor Blitzschlägen dienen sollte: den Blitzableiter. Diese aus heutiger Sicht scheinbar triviale Vorrichtung wurde aber keineswegs unmittelbar akzeptiert. Und bis heute ist die Forschung zum Schutz von Einrichtungen vor Blitzschlägen nicht abgeschlossen.

Heering, Peter

2002-05-01

232

Autoradiographische Abbildung von N-Verteilungen mit Festkörperspurdetektoren  

Microsoft Academic Search

Laterale Verteilungen von Stickstoff in Festkörpern können mit Hilfe der nentroneninduzierten Autoradiographie auf Grund der Reaktion N (n, p)C aufgenommen werden. Als Festkörperspurdetektor werden kommerzielle Zellulosenitratfolien vom Typ LR 115 und CA 80—15 und auch selbsthergestellte CN-Folien eingesetzt. Die Ätz- und Bestrahlungsbedingungen werden dargestellt. Aus experimentellen Untersuchungen biologischer Objekte und stickstoffhaltiger Festkörperproben etgab sich für Stickstoff eine untere Nachweisgrenze von

K. Freyer; W. Birkholz; H. C. Treutler; M. Wolff

1978-01-01

233

Die embryonalentwicklung von Monocelis Fusca oersted (Turbellaria, Proseriata)  

Microsoft Academic Search

1.Die Art Monocelis fusca steht im Mittelpunkt einer eingehenden Untersuchung der Embryogenese proseriater Turbellarien. Ergebnisse von mehreren verwandten Arten sind in die Darstellung eingearbeitet.2.Alle Vertreter der Familien Monocelididae und Otoplanidae besitzen ein großes Regenerationsvermogen. Eine vollständige Regeneration findet nur bei Vorderkörpern mit dem Gehirn statt. An abgetrennte Vorderenden wird in der kurzen Zeit von 3–4 Tagen ein vollständiger Mittel- und

Siegfried Giesa

1966-01-01

234

Trendforschung und die Entwicklung von Konfliktbildern in der Bundeswehr  

Microsoft Academic Search

Zusammenfassung  Die Trend- und Zukunftsforschung hat sich als systematische Untersuchungsmethode der zu erwartenden sicherheitspolitischen\\u000a Entwicklung etabliert. Die Ergebnisse eines Forschungsprojekts der Bundeswehr prognostizieren u.a. fließende Übergänge zwischen\\u000a Kriegs- und Friedensphasen sowie eine zunehmende Vermengung von Gewaltanwendung und Erwerbsmöglichkeiten. Daraus folgt, dass\\u000a Streitkräfte hauptsächlich vernetzte Ansätze zur Herstellung von Sicherheit wählen werden.

Ralph Thiele

2009-01-01

235

Wirkungsdauer und enterale Resorption von Digitoxigenin-monodigitoxosid (Dt 21)  

Microsoft Academic Search

Im akuten Versuch, d.h. bei i.v. Dauerinfusion, waren Digitoxigenintridigitoxosid (Digitoxin) und Digitoxigenin-mono-digitoxosid (Dt 21) gleich wirksam (Kroneberg). Injiziert man die Glykoside s.c. und beobachtet die Tiere über 2 Wochen, so liegt die tödliche Dosis von Dt 21 dagegen mehr als zweimal so hoch wie die von Digitoxin. Das wird darauf zurückgeführt, daß das letzte Digitoxose-Molekül leicht abgespalten und Dt 21

G. Kroneberg; W. Schaumann; K. Stoepel

1962-01-01

236

Wernher von Braun with German Officers and Others  

NASA Technical Reports Server (NTRS)

General Erich Fellgiebel, head of the German Army Information Service during World War II, congratulates members of the von Braun rocket team from Peenemunde for their October 3, 1942 A4 flight. Pictured front center is General Erich Fellgiebel. Shaking hands are General Walter Dornberger (left) and General Janssen, commanding officer of Peenemuende with Rudolph Hermarn to their right. Picture left to right in the back row are Wernher von Braun, Captain Stoelzel, Luftwaffe, and Dr. Gerhard Reisig.

1942-01-01

237

On Quantitative Rorschach Scales.  

ERIC Educational Resources Information Center

Two types of quantitative Rorschach scales are discussed: first, those based on the response categories of content, location, and the determinants, and second, global scales based on the subject's responses to all ten stimulus cards. (Author/JKS)

Haggard, Ernest A.

1978-01-01

238

Recapturing Quantitative Biology.  

ERIC Educational Resources Information Center

Presents a classroom activity on estimating animal populations. Uses shoe boxes and candies to emphasize the importance of mathematics in biology while introducing the methods of quantitative ecology. (JRH)

Pernezny, Ken; And Others

1996-01-01

239

Quantitative thallium imaging  

SciTech Connect

There has been much recent interest in quantitative interpretation of 201thallium myocardial imaging. Quantitative analysis can be used as an aid in the more accurate interpretation of myocardial scans. Quantitative analysis is essential to extract information about the kinetics of thallium redistribution. This article briefly reviews the mechanism of uptake and redistribution of 201thallium in the heart and the effect of dipyridamole on uptake and redistribution. Several of the algorithms that have been used to quantitate 201thallium distribution and kinetics on planar studies and the value of quantification on diagnostic accuracy are described. Proper utilization of these methods depends upon a complete understanding of the assumption and the limitations of these algorithms.108 references.

Charron, M.; Parker, J.A. (Harvard Medical School, Boston, MA (USA))

1989-01-01

240

Quantitative thallium imaging.  

PubMed

There has been much recent interest in quantitative interpretation of 201thallium myocardial imaging. Quantitative analysis can be used as an aid in the more accurate interpretation of myocardial scans. Quantitative analysis is essential to extract information about the kinetics of thallium redistribution. This article briefly reviews the mechanism of uptake and redistribution of 201thallium in the heart and the effect of dipyridamole on uptake and redistribution. Several of the algorithms that have been used to quantitate 201thallium distribution and kinetics on planar studies and the value of quantification on diagnostic accuracy are described. Proper utilization of these methods depends upon a complete understanding of the assumption and the limitations of these algorithms. PMID:2688679

Charron, M; Parker, J A

1989-01-01

241

Changes in Thermodynamic Stability of von Willebrand Factor Differentially Affect the Force-Dependent Binding to Platelet GPIb?  

PubMed Central

Abstract In circulation, plasma glycoprotein von Willebrand Factor plays an important role in hemostasis and in pathological thrombosis under hydrodynamic forces. Mutations in the A1 domain of von Willebrand factor cause the hereditary types 2B and 2M von Willebrand disease that either enhance (2B) or inhibit (2M) the interaction of von Willebrand factor with the platelet receptor glycoprotein Ib?. To understand how type 2B and 2M mutations cause clinically opposite phenotypes, we use a combination of protein unfolding thermodynamics and atomic force microscopy to assess the effects of two type 2B mutations (R1306Q and I1309V) and a type 2M mutation (G1324S) on the conformational stability of the A1 domain and the single bond dissociation kinetics of the A1-GPIb? interaction. At physiological temperature, the type 2B mutations destabilize the structure of the A1 domain and shift the A1-GPIb? catch to slip bonding to lower forces. Conversely, the type 2M mutation stabilizes the structure of the A1 domain and shifts the A1-GPIb? catch to slip bonding to higher forces. As a function of increasing A1 domain stability, the bond lifetime at low force decreases and the critical force required for maximal bond lifetime increases. Our results are able to distinguish the clinical phenotypes of these naturally occurring mutations from a thermodynamic and biophysical perspective that provides a quantitative description of the allosteric coupling of A1 conformational stability with the force dependent catch to slip bonding between A1 and GPIb?.

Auton, Matthew; Sedlak, Erik; Marek, Jozef; Wu, Tao; Zhu, Cheng; Cruz, Miguel A.

2009-01-01

242

Multivariate Quantitative Chemical Analysis  

NASA Technical Reports Server (NTRS)

Technique of multivariate quantitative chemical analysis devised for use in determining relative proportions of two components mixed and sprayed together onto object to form thermally insulating foam. Potentially adaptable to other materials, especially in process-monitoring applications in which necessary to know and control critical properties of products via quantitative chemical analyses of products. In addition to chemical composition, also used to determine such physical properties as densities and strengths.

Kinchen, David G.; Capezza, Mary

1995-01-01

243

An apparently silent nucleotide substitution (c.7056C>T) in the von Willebrand factor gene is responsible for type 1 von Willebrand disease  

PubMed Central

Background Nucleotide variations not changing protein sequences are considered silent mutations; accumulating data suggest that they can, however, be important in human diseases. Design and Methods We report an altered splicing process induced by a silent substitution (c.7056C>T) in the von Willebrand factor gene in a case of type 1 von Willebrand disease originally classified as lacking von Willebrand factor mutations. Results The c.7056C>T synonymous substitution introduces a new donor splice site within exon 41, leading to messenger RNA lacking nucleotides 7055-7081 (c.7055_7081del). The encoded von Willebrand factor protein is predicted to lack amino acids 2352-2360 in the B2 domain. The patient’s von Willebrand disease phenotype was characterized by reduced plasma and platelet von Willebrand factor, which was normal in function and multimer structure. In vitro expression studies demonstrated that co-transfection of equimolar c.7055_7081del and wild-type von Willebrand factor (mimicking the patient’s heterozygous state) induced a 50% lower von Willebrand factor secretion than the wild type, while almost no von Willebrand factor secretion was seen with the mutated von Willebrand factor alone. The secreted von Willebrand factor was structurally and functionally normal, suggesting that the c.7056C>T substitution behaves like a loss-of-function allele. Conclusions This is the first report of a synonymous von Willebrand factor substitution being responsible for von Willebrand disease. Our findings suggest the need to reconsider the role of von Willebrand factor polymorphisms in von Willebrand disease.

Daidone, Viviana; Gallinaro, Lisa; Grazia Cattini, Maria; Pontara, Elena; Bertomoro, Antonella; Pagnan, Antonio; Casonato, Alessandra

2011-01-01

244

Selective Absence of Large Forms of Factor Vill\\/von Willebrand Factor in Acquired von Willebrand's Syndrome. Response to Transfusion  

Microsoft Academic Search

A previously healthy elderly man with mucocutaneous bleeding was found to have a benign monoclonal lgG gammapathy associated with criteria for severe von Willebrand disease (Factor VIII procoagu- lant activity, Factor-VIII-related antigen, and ristocetin cofactor activity, <10% of normal). Associated qualitative abnormali- ties of factor VIII\\/von Willebrand factor were demonstrated by radiocrossed immu- noelectrophoresis and immunoradiometric assay. The late clinical

D. Meyer; D. Frommel; M. J. Larrieu; T. S. Zimmerman

1979-01-01

245

In Vivo Interaction of von Willebrand Factor With Platelets Following Cryoprecipitate Transfusion in Platelet-Type von Willebrand's Disease  

Microsoft Academic Search

Previous studies performed in vitro have indicated that platelets from patients with platelet-type von Willebrand's disease (vWD) have receptors for von Willebrand factor (vWF) already exposed on their surfaces and that the addition of purified vWF or cryoprecipitate to patient platelet-rich plasma under stirring conditions is capable of inducing platelet aggregation and secretion. The present work reports the results of

Jonathan L. Miller; Bruce D. Boselli; John M. Kupinski

1984-01-01

246

Untersuchungen zum Gesundheitsstatus von Kanadagänsen ( Branta canadensis , Linnaeus, 1758) in Nordrhein-Westfalen an Hand der Analyse von Eiern  

Microsoft Academic Search

Zusammenfassung 107 Eier der Kanadagans aus Gelegen im Bereich des Naherholungsgebietes „Saaler Mühle“ in Nordrhein-Westfalen wurden morphometrisch, mikrobiologisch und serologisch untersucht. Untersucht wurde auf Erreger oder gegen diese gerichtete Antikörper von (i) Zoonosen (Salmonella sp.,Campylobacter sp.,Chlamydia sp.), (ii) die Erreger oder deren Antikörper von Tierseuchen (Virus der Newcastle Disease, Influenza A-Virus der Hämagglutinin (HA-)-Subtypen H5 und H7), (iii) Erreger oder

Brigitte M. Bönner; Sabine Jäger; Ursula Reichel; Walburga Lutz; J. Wissing; W. Knickmeier; W. H. Gerlich; Ulrike C. Wend; Annette L. Bolte; E. F. Kaleta

2003-01-01

247

Variabilität des Reviergesangs des Buchfinken (Fringilla coelebs) zur Raum-Zeit-Beschreibung von Metapopulationen  

NASA Astrophysics Data System (ADS)

Der Buchfinkengesang wurde in Potsdam in zwei Hauptpopulationen über drei Jahre aufgenommen. Jedes Individuum wurde eindeutig am individuellen Strophentypenrepertoire identifiziert. Ein weiterer Punkt der die individuelle Wiedererkennung bestätigt ist die hohe Standorttreue der adulten Männchen. Die beschriebene Methode eignet sich für die Untersuchung von gesamten Populationen, um den Wandel des Gesangs von Populationen in Raum und Zeit zu beschreiben. Die Haupterkenntnisse der Arbeit sind: - Die Gesamtanzahl der Grundstrophentypen innerhalb einer Population bleibt über Jahre konstant. - Die relative Häufigkeit jedes einzelnen Strophentyps variiert von Jahr zu Jahr und von Population zu Population. - Gesangslernen erfolgt exakt mit einem Korrektheitsgrad von mindestens 96%. - Das Song-Sharing ist innerhalb der Population hoch. Die diskutierten Mechanismen für das Song-Sharing sind: Die Lebenserwartung, das Zugverhalten, das Lernverhalten, die Etabliertheit von Strophentypen, Weibchenpräferenzen und die Reaktionen der territorialen Männchen. - Weiterhin wurde ein Modell zur kulturellen Evolution des Buchfinkengesangs programmiert, um die Rolle der Einflussfaktoren, wie Fehlerquote, Abwanderungsrate und Laufzeit zu ermitteln. Der Wandel des Dialektes erfolgt graduell in Raum und Zeit. Daher sind keine scharfen Dialektgrenzen anzutreffen. Trotz dieser Tatsache markieren die etablierten Strophentypen die Population. 50 % der Juvenilen siedeln am Geburtsort, auf diese Weise bleibt der Dialekt erhalten und Inzest wird vermieden. -Analysiert man das Repertoire benachbarten Männchen bei isolierten Alleen, so entspricht die Gesangsangleichung in etwa dem Zufall. -Intraindividuelle Vergleiche der quantitativen Parameter des jeweiligen Strophentyps wurden saisonal und annuell durchgeführt. Saisonal konnten für einen Strophentyp ein Trend ermittelt werden. Bei jährlichen Vergleichen konnten intraindividuell ausschließlich nicht signifikante Ergebnisse ermittelt werden, wohingegen die interindividuelle Variation in zwei Fällen signifikant war. In einem Fall bestand ein Trend und in einem weiteren Fall war die Variationsunterschiede nicht signifikant. - Der Verlauf der Brutsaison lässt sich an der jährlichen Gesangsaktivität nachvollziehen. Chaffinch song was recorded in Potsdam in two major populations of chaffinches over a period of three years. Each male was identified unambiguously because of their individual song type repertoires. These are usually easy to distinguish from sonagrams as the variation is discontinuous. A further point for individual recognition is the fixed territorial behaviour of adult males. The described method is employed to examine whole populations and to observe changes with space and time in the song of a population. The major findings of the study are: - The total amount of basic song types in each population is constant over years. - The quantity of each basic song type is different and varies from year to year and from population to population. - Song copying is extremely accurate on at least 96% of occasions. - Song-type sharing is high within populations. Discussed mechanisms for song neighbourhoods are: expectation of life, semi-migratory behaviour, learning skills, establishment of song types, female choice and male vs male interaction. Furthermore a model of cultural evolution of chaffinch song was programmed to determine the role of factors like error rate, rate of emigration and running time. The changes are gradual in space and time. Hence the dialect borders are smooth. Despite this fact established song types mark the population. As every second juvenile bird settles in the population of his birth inbreeding is avoided and the dialect structure is retained. - Analysing the repertoires of neighbouring males (“next door neighbours”) in isolated avenues to examine mutual influences suggests that these have the same amount of song types in common than would be expected by chance. - Within intraindividual comparisons the quantitative parameters of the same son

Nolte, Björn

2003-10-01

248

Wärmeleitzahl-Messungen an Wasser, Äthylenglykol-Wasser-Mischungen Kalziumchlorid-Lösungen im Temperaturereich von 0 bis 100°C  

Microsoft Academic Search

Zusammenfassung  Mit Hilfe einer Przisions-Meanordnung gelang es, die Wrmeleitzahl von thylenglykol-Wasser-Mischungen, von wrigen Kalziumchlorid-Lsungen\\u000a und von Wasser zwischen 0 und 100C genauer als bisher zu bestimmen. Bei den Kalziumchlorid-Lsungen konnte der frher von\\u000a W. Rau gefundene Sprung der Wrmeleitzahl bei der Konzentration des kryohydratischen Punktes nicht besttigt werden. Die von\\u000a W. Kraus beobachtete Anomalie im Temperaturverlauf der Wrmeleitzahl von thylenglykol tritt

Ernst Schmidt; W. Leidenfrost

1955-01-01

249

Quantitative aspects of septicemia.  

PubMed Central

For years, quantitative blood cultures found only limited use as aids in the diagnosis and management of septic patients because the available methods were cumbersome, labor intensive, and practical only for relatively small volumes of blood. The development and subsequent commercial availability of lysis-centrifugation direct plating methods for blood cultures have addressed many of the shortcomings of the older methods. The lysis-centrifugation method has demonstrated good performance relative to broth-based blood culture methods. As a result, quantitative blood cultures have found widespread use in clinical microbiology laboratories. Most episodes of clinical significant bacteremia in adults are characterized by low numbers of bacteria per milliliter of blood. In children, the magnitude of bacteremia is generally much higher, with the highest numbers of bacteria found in the blood of septic neonates. The magnitude of bacteremia correlates with the severity of disease in children and with mortality rates in adults, but other factors play more important roles in determining the patient's outcome. Serial quantitative blood cultures have been used to monitor the in vivo efficacy of antibiotic therapy in patients with slowly resolving sepsis, such as disseminated Mycobacterium avium-M. intracellulare complex infections. Quantitative blood culture methods were used in early studies of bacterial endocarditis, and the results significantly contributed to our understanding of the pathophysiology of this disease. Comparison of paired quantitative blood cultures obtained from a peripheral vein and the central venous catheter has been used to help identify patients with catheter-related sepsis and is the only method that does not require removal of the catheter to establish the diagnosis. Quantitation of bacteria in the blood can also help distinguish contaminated from truly positive blood cultures; however, no quantitative criteria can invariably differentiate contamination from bacteremia.

Yagupsky, P; Nolte, F S

1990-01-01

250

Löslichkeitskonstanten und freie Bildungsenthalpien von Metallsulfiden, 5. Mitt.: Die Löslichkeit von ?-MnS (Alabandin)  

Microsoft Academic Search

Zusammenfassung Die Löslichkeit von a-MnS (Alabandin) in Medien der allgemeinen ZusammensetzungL ([H+]=HM, [Na+]=(3,000-H)M, [ClO4-]=3,000M) wurde bei 25°C und bestimmtem H2S-Partialdruck untersucht. Die Wasserstoffionenkonzentration und die totale Mn(II)-Ionenkonzentration im Gleichgewicht mit der festen Phase wurde durch elektrochemische bzw. analytische Methoden ermittelt. Die Ergebnisse lassen sich durch die Reaktion\\u000a$$\\\\alpha --MnS_{(s)} + 2H_{(l)}^ + = Mn_{(1)}^{2 + } + H_2 S_{(g)} $$

H. Gamsjäger

1967-01-01

251

Quantitative Autonomic Testing  

PubMed Central

Disorders associated with dysfunction of autonomic nervous system are quite common yet frequently unrecognized. Quantitative autonomic testing can be invaluable tool for evaluation of these disorders, both in clinic and research. There are number of autonomic tests, however, only few were validated clinically or are quantitative. Here, fully quantitative and clinically validated protocol for testing of autonomic functions is presented. As a bare minimum the clinical autonomic laboratory should have a tilt table, ECG monitor, continuous noninvasive blood pressure monitor, respiratory monitor and a mean for evaluation of sudomotor domain. The software for recording and evaluation of autonomic tests is critical for correct evaluation of data. The presented protocol evaluates 3 major autonomic domains: cardiovagal, adrenergic and sudomotor. The tests include deep breathing, Valsalva maneuver, head-up tilt, and quantitative sudomotor axon test (QSART). The severity and distribution of dysautonomia is quantitated using Composite Autonomic Severity Scores (CASS). Detailed protocol is provided highlighting essential aspects of testing with emphasis on proper data acquisition, obtaining the relevant parameters and unbiased evaluation of autonomic signals. The normative data and CASS algorithm for interpretation of results are provided as well.

Novak, Peter

2011-01-01

252

Quantitative Glycomics Strategies*  

PubMed Central

The correlations between protein glycosylation and many biological processes and diseases are increasing the demand for quantitative glycomics strategies enabling sensitive monitoring of changes in the abundance and structure of glycans. This is currently attained through multiple strategies employing several analytical techniques such as capillary electrophoresis, liquid chromatography, and mass spectrometry. The detection and quantification of glycans often involve labeling with ionic and/or hydrophobic reagents. This step is needed in order to enhance detection in spectroscopic and mass spectrometric measurements. Recently, labeling with stable isotopic reagents has also been presented as a very viable strategy enabling relative quantitation. The different strategies available for reliable and sensitive quantitative glycomics are herein described and discussed.

Mechref, Yehia; Hu, Yunli; Desantos-Garcia, Janie L.; Hussein, Ahmed; Tang, Haixu

2013-01-01

253

The molecular analysis of von Willebrand disease: a guideline from the UK Haemophilia Centre Doctors' Organisation Haemophilia Genetics Laboratory Network.  

PubMed

von Willebrand disease (VWD) is a common autosomally inherited bleeding disorder associated with mucosal or trauma-related bleeding in affected individuals. VWD results from a quantitative or qualitative deficiency of von Willebrand factor (VWF), a glycoprotein that is essential for primary haemostasis and that carries and protects coagulation factor VIII (FVIII) in the circulation. Through characterization of the phenotype and identification of mutations in the VWF gene in patients with VWD, understanding of the genetics and biochemistry of VWF and VWD has advanced considerably. The importance of specific regions of VWF for its interaction with other components of the vasculature has been revealed, and this has facilitated the formal classification of VWD into three subtypes based upon quantitative (types 1 and 3) and qualitative (type 2) deficiency of VWF. The underlying genetic lesions and associated molecular pathology have been identified in many cases of the qualitative type 2 VWD variants (2A, 2B, 2M, 2N) and in the severe quantitative deficiency, type 3 VWD. However in the partial quantitative deficiency, type 1 VWD, the picture is less clear: there is a variable relationship between plasma levels of VWF and bleeding, there is incomplete penetrance and variable expressivity within affected families, the causative molecular defect is unknown in a substantial number of cases, and even in those cases where the causative mutation is known, the associated molecular pathology is not necessarily understood. This guideline aims to provide a framework for best laboratory practice for the genetic diagnosis of VWD, based upon current knowledge and understanding. PMID:18637846

Keeney, S; Bowen, D; Cumming, A; Enayat, S; Goodeve, A; Hill, M

2008-09-01

254

Implementierung von Motorvermessungsmethoden für die Prüfstandsautomatisierung  

NASA Astrophysics Data System (ADS)

Antriebsstrang Applikationsprozesse werden zunehmend kritischer. Die steigenden Erwartungen an ein Fahrzeug und die Kundenzufriedenheit sind der treibende Faktor für Verbesserungen, insbesondere hinsichtlich der transienten Performance, des Fahrverhaltens und der Reduzierung des Verbrauchs. Gleichzeitig müssen striktere Emissions-Grenzwerte erfüllt werden. Dies führt zwangsläufig zu einer komplexeren Antriebsstrang-Hardware, einschließlich Sensoren und Aktuatoren. Steuergeräte werden immer leistungsfähiger, Modelle immer komplexer, die Anzahl von parametrierbaren Labels in den Modellen steigt ständig. Das Gesamtsystem Mechanik, Hydraulik, Thermodynamik und Elektronik und die Interaktion der einzelnen Komponenten wird zum entscheidenden Erfolgsfaktor für Projekte. Deshalb wurde ein Smart-Calibration-Prozess entwickelt. "Smart Calibration ist ein verfolgbares und wieder verwendbares Konzept, welches die Qualität und die Effizienz der Applikation steigert. Basierend auf qualitativ hochwertigen Messergebnissen können diese schnellstmöglich hereingefahren und die notwendige Anzahl der Messungen auf ein Minimum reduziert werden. Darüber hinaus dürfen einzelne Entwicklungsschritte nicht an die klassischen Entwicklungsumgebungen gebunden sein. Eine Flexibilisierung schafft deutliche Fortschritte in Effektivität und Effizienz. Ohne durchgängige Plattform Lösungen mit professionellen Produkten kann eine nachhaltige Produktivitätssteigerung im weltweiten Wettbewerb nicht realisiert werden.

Martini, Eike; Wellers, Matthias

255

Unwinding the von Willebrand factor strings puzzle.  

PubMed

von Willebrand factor (VWF) is amongst others synthesized by endothelial cells and stored as ultra-large (UL) VWF multimers in Weibel-Palade bodies. Although UL-VWF is proteolysed by ADAMTS13 (a disintegrin-like and metalloprotease domain with thrombospondin type-1 motif, number 13) on secretion from endothelial cells, in vitro experiments in the absence of ADAMTS13 have demonstrated that a proportion of these UL-VWF multimers remain anchored to the activated endothelium. These multimers unravel, bind platelets, and wave in the direction of the flow. These so-called VWF "strings" have also been visualized in vivo, lining the lumen of activated mesenteric veins of Adamts13(-/-) mice. Various studies have demonstrated the extraordinary length of these VWF strings, the availability of their platelet binding and ADAMTS13 cleavage sites, and the possible nature of their endothelial attachment. VWF strings are also capable of tethering leukocytes and parasite-infected red blood cells. However, the majority of studies have been performed in the absence of ADAMTS13, a condition only experienced in thrombotic thrombocytopenic purpura. A normal functional role of VWF strings in healthy persons or in other disease pathologies remains unclear. In this review, we discuss some of the puzzling characteristics of VWF strings, and we debate whether the properties of VWF strings in the absence of ADAMTS13 might be relevant for understanding (patho)physiologic mechanisms. PMID:23093621

De Ceunynck, Karen; De Meyer, Simon F; Vanhoorelbeke, Karen

2013-01-10

256

Quantitative Hydrocarbon Surface Analysis  

NASA Technical Reports Server (NTRS)

The elimination of ozone depleting substances, such as carbon tetrachloride, has resulted in the use of new analytical techniques for cleanliness verification and contamination sampling. The last remaining application at Rocketdyne which required a replacement technique was the quantitative analysis of hydrocarbons by infrared spectrometry. This application, which previously utilized carbon tetrachloride, was successfully modified using the SOC-400, a compact portable FTIR manufactured by Surface Optics Corporation. This instrument can quantitatively measure and identify hydrocarbons from solvent flush of hardware as well as directly analyze the surface of metallic components without the use of ozone depleting chemicals. Several sampling accessories are utilized to perform analysis for various applications.

Douglas, Vonnie M.

2000-01-01

257

Quantitative computed tomography.  

PubMed

Unlike dual x-ray absorptiometry and high-resolution CT scan and MR imaging techniques, which are largely restricted to the peripheral skeleton owing to radiation dose and signal-to-noise considerations, volumetric quantitative measures provide measures of cortical and trabecular volumetric bone mineral density, cross-sectional geometry, and estimates of whole-bone strength based on patient specific finite element modeling. This article focuses on the application of volumetric quantitative measures to studies of aging, disuse, and drug treatment as related to osteoporosis. PMID:20609894

Lang, Thomas F

2010-05-01

258

An Alternative to Von Glasersfeld's Subjectivism in Science Education: Deweyan Social Constructivism.  

ERIC Educational Resources Information Center

Discusses von Glasersfeld's view of constructivism in science and mathematics educational research and practice. Provides a social constructivist alternative to von Glaserfeld's subjectivist constructivism. Discusses the practical art of experimental construction and objectivity in science education. (Author/JRH)

Garrison, Jim

1997-01-01

259

Evaluation of an automated von Willebrand factor activity assay in von Willebrand disease.  

PubMed

We evaluated the use of the turbidimetric HemosIL von Willebrand Factor (VWF) Activity assay (VWF:Act) on the STA-R automated coagulometer (Stago, Asnières, France) for the diagnosis of von Willebrand disease (VWD). For this, we prospectively screened 268 patients. As a second part, we retrospectively assayed 111 patients with well-defined VWD subtype. In the first prospective study, we demonstrate that in most cases of VWD, VWF ristocetin cofactor activity (VWF:RCo) and VWF:Act are highly correlated but that they both cannot be considered a good screening assay when used alone, since they could miss about 25% of VWF abnormalities. However, the association of VWF:Act analysis and the Platelet Function Analyzer-100 (PFA-100) test constitutes an excellent screening strategy. In our second retrospective study concerning VWD subtypes, VWF:RCo and VWF:Act were well correlated but could be very discrepant, especially for some cases of type 2M VWD. We consider that VWF:RCo remains the "reference assay" for VWD subtype classification. PMID:20724302

Trossaërt, Marc; Ternisien, Catherine; Lefrancois, Armelle; Llopis, Laura; Goudemand, Jenny; Sigaud, Marianne; Fouassier, Marc; Caron, Claudine

2011-01-01

260

Porcine and Canine von Willebrand Factor and von Willebrand Disease: Hemostasis, Thrombosis, and Atherosclerosis Studies  

PubMed Central

Use of animal models of inherited and induced von Willebrand factor (VWF) deficiency continues to advance the knowledge of VWF-related diseases: von Willebrand disease (VWD), thrombotic thrombocytopenic purpura (TTP), and coronary artery thrombosis. First, in humans, pigs, and dogs, VWF is essential for normal hemostasis; without VWF bleeding events are severe and can be fatal. Second, the ADAMTS13 cleavage site is preserved in all three species suggesting all use this mechanism for normal VWF multimer processing and that all are susceptible to TTP when ADAMTS13 function is reduced. Third, while the role of VWF in atherogenesis is debated, arterial thrombosis complicating atherosclerosis appears to be VWF-dependent. The differences in the VWF gene and protein between humans, pigs, and dogs are relatively few but important to consider in the design of VWF-focused experiments. These homologies and differences are reviewed in detail and their implications for research projects are discussed. The current status of porcine and canine VWD are also reviewed as well as their potential role in future studies of VWF-related disorders of hemostasis and thrombosis.

Nichols, Timothy C.; Bellinger, Dwight A.; Merricks, Elizabeth P.; Raymer, Robin A.; Kloos, Mark T.; DeFriess, Natalie; Ragni, Margaret V.; Griggs, Thomas R.

2010-01-01

261

Entwicklungsperspektiven von Social Software und dem Web 2.0  

NASA Astrophysics Data System (ADS)

Der Artikel beschäftigt sich zunächst mit dem derzeitigen und zukünftigen Einsatz von Social Software in Unternehmen. Nach dem großen Erfolg von Social Software im Web beginnen viele Unternehmen eigene Social Software-Initiativen zu entwickeln. Der Artikel zeigt die derzeit wahrgenommenen Einsatzmöglichkeiten von Social Software im Unternehmen auf, erörtert Erfolgsfaktoren für die Einführung und präsentiert mögliche Wege für die Zukunft. Nach der Diskussion des Spezialfalles Social Software in Unternehmen werden anschließend die globalen Trends und Zukunftsperspektiven des Web 2.0 in ihren technischen, wirtschaftlichen und sozialen Dimensionen dargestellt. Wie aus den besprochenen Haupttrends hervorgeht, wird die Masse an digital im Web verfügbaren Informationen stetig weiterwachsen. So stellt sich die Frage, wie es in Zukunft möglich sein wird, die Qualität der Informationssuche und der Wissensgenerierung zu verbessern. Mit dem Einsatz von semantischen Technologien im Web wird hier eine revolutionäre Möglichkeit geboten, Informationen zu filtern und intelligente, gewissermaßen verstehende" Anwendungen zu entwerfen. Auf dem Weg zu einem intelligenten Web werden sich das Semantic Web und Social Software annähern: Anwendungen wie Semantic Wikis, Semantic Weblogs, lightweight Semantic Web-Sprachen wie Microformats oder auch kommerzielle Angebote wie Freebase von Metaweb werden die ersten Vorzeichen einer dritten Generation des Webs sein.

Raabe, Alexander

262

Hypertrophic Obstructive Cardiomyopathy, Bleeding History, and Acquired von Willebrand Syndrome: Response to Septal Myectomy  

PubMed Central

Bleeding with severe aortic stenosis is linked to acquired von Willebrand syndrome and loss of high-molecular-weight multimers of von Willebrand factor. Valve replacement resolves bleeding tendency and loss of high-molecular-weight multimers. We report outcomes in 5 patients with symptomatic obstructive hypertrophic cardiomyopathy and spontaneous gastrointestinal, mucosal, or excessive postsurgical bleeding in whom acquired von Willebrand syndrome was documented. All 5 patients underwent surgical septal myectomy with resolution of acquired von Willebrand syndrome.

Blackshear, Joseph L.; Schaff, Hartzell V.; Ommen, Steve R.; Chen, Dong; Nichols, William L.

2011-01-01

263

Innovation im Mittelstand am Beispiel Der Senkung Von Mobilitätskosten Durch Schwarmintelligenz"  

NASA Astrophysics Data System (ADS)

Die zunehmende Vernetzung von Einzelsystemen im Fahrzeug wird durch den Einsatz weiterer Kommunikationsverbindungen (CAR2X-Kommunikation) zu einer hierarchischen Struktur führen, die den Austausch von Informationen zwischen einer Vielzahl von verteilten heterogenen Subsystemen auf mobilen und stationären Plattformen ermöglicht. Die primären Ziele einer solchen Vernetzung von Cyber-Physical Systems sind die Bereitstellung neuer Dienste im Fahrzeug, die Erhöhung der Verkehrssicherheit sowie die effektive Steuerung der weiter wachsenden Verkehrsströme.

Fischer, Hieronymus

264

Quantitative Millimetre Wavelength Spectrometry  

Microsoft Academic Search

This monograph presents an introduction to the current status and future potential in the application of millimetre wavelength spectrometry to the quantitative analysis of gaseous mixtures. It will therefore be of interest for chemists and other people working in this field or for those who want to start working there.Within the spectrum of electromagnetic waves, the millimetre wave range is

John F Alder; John G Baker

2002-01-01

265

Testing quantitation in PET  

Microsoft Academic Search

This study tests the use of contrast recovery coefficient (CRC) plots in comparison with piephantom linearity plots for assessing quantitation in PET. CRC plots show normalized object\\/background activity ratios measured from the reconstructed image as a function of object size. A 6 compartment 15cm diameter piephantom was scanned on the Therascan and Positome III PET machines. CRC data was obtained

S. C. Strother; C. J. Thompson; A. C. Evans

1984-01-01

266

Quantitative criteria for insomnia  

Microsoft Academic Search

Formal diagnostic systems (DSM-IV, ICSD, and ICD-10) do not provide adequate quantitative criteria to diagnose insomnia. This may not present a serious problem in clinical settings where extensive interviews determine the need for clinical management. However, lack of standard criteria introduce disruptive variability into the insomnia research domain. The present study reviewed two decades of psychology clinical trials for insomnia

K. L. Lichstein; H. H. Durrence; D. J. Taylor; A. J. Bush; B. W. Riedel

2003-01-01

267

Quantitative Graphics in Newspapers.  

ERIC Educational Resources Information Center

The use of quantitative graphics in newspapers requires achieving a balance between being accurate and getting the attention of the reader. The statistical representations in newspapers are drawn by graphic designers whose key technique is fusion--the striking combination of two visual images. This technique often results in visual puns,…

Tankard, James W., Jr.

268

Quantitative Methods for Management.  

National Technical Information Service (NTIS)

An elementary treatment of some of the better known and widely used analytical methods in operations research/systems analysis. The material is presented in a manner which attempts to indicate why quantitative methods are useful in managerial decision-mak...

G. Suzuki

1967-01-01

269

Evaluation of von Willebrand factor activity in factor VIII/von Willebrand factor concentrates with the automated von Willebrand factor: activity IL test.  

PubMed

The von Willebrand ristocetin cofactor assay is still the main cleared measurement test used to evaluate von Willebrand factor (vWF) activity in concentrate samples containing vWF. Although the assay's performance has been improved over the years, the test reliability is still affected by a high interassay and interlaboratory variability; moreover, it requires skilled technicians and significant time. An automated HemosIL vWF:activity test, already set up on plasma samples, was then applied to factor VIII/vWF concentrates to verify its suitability in routine analysis of concentrate samples. As first step precision, linearity and accuracy were assessed. Then, 40 commercial batches of a high purity factor VIII/vWF concentrate were examined with this new method. The Spearman's correlation between the results obtained with the HemosIL vWF:activity assay and vWF activities determined by established procedures was evaluated. Comparisons of the means between HemosIL vWF:activity and the other tests were calculated with the Wilcoxon and Bland-Altman tests. Validation study showed satisfying within-run and between-run precision values. Activities determined with HemosIL vWF:activity had good correlation with those determined as ristocetin cofactor, Imubind (vWF:Imubind) and collagen-binding. Wilcoxon test, used to compare the means between the HemosIL vWF:activity and the other activity assessments, proved no significant variation with vWF:Imubind, but displayed a slight variation with von Willebrand ristocetin cofactor and von Willebrand factor:collagen-binding. This automated HemosIL vWF:activity test could be included in routine determination of vWF activity in concentrate samples and supports traditional von Willebrand ristocetin cofactor because it is reliable, reproducible and sensitive. PMID:20179578

Mori, Filippo; Rossi, Paola; Nardini, Ilaria; Gambelli, Davide; Farina, Claudio

2010-04-01

270

Kartierung von wassergesättigten Firnschichten auf dem Kesselwandferner mit dem EMR-Verfahren  

Microsoft Academic Search

Zusammenfassung: Die räumliche Verteilung von Wasser im Akkumulationsgebiet eines Gletschers ist im Zusammenhang mit der hydrolo­ gischen Bilanz des Einzugsgebietes von besonderem Interesse. Es ist bekannt, daß sich im Akkumulationsgebiet von Alpengletschern an der Grenzfläche zwischen wasserdurchlässigern Firn und wasserundurchlässigem Gletschereis eine Wassertafel ausbildet, deren Ortung bisher nur durch Bohrung möglich war. Daher war die Erprobung eines elektromagnetischen Impulsverfahrens (Elvl

Von F. Thyssen; H. Eisner; N. Blindow; W. Ambach

271

Röntgenologische Untersuchungen zur Lageabhängigkeit der tiefen Hirnvenen, insbesondere des Angulus venosus von der Form des Schädels  

Microsoft Academic Search

Zusammenfassung Die Lageabhängigkeit der tiefen Hirnvenen, insbesondere des Angulus venosus, von der Form des Schädels wird durch zahlreiche Streckenverhältnisse (prozentuale Unterteilung von benachbarten Strecken durch senkrechte Projektion des Angulus venosus auf diese) und durch Winkel mit verschiedenen Scheitelpunkten (an der Schädelbasis, an der Schädelkalotte und intracraniell) geprüft. — Von den Streckenverhältnismaßen eignen sich zur Lokalisation des Angulus venosus die Relationen

Erich Fischer

1966-01-01

272

Wann ist die Kavernosographie und -metrie vor der Implantation von Schwellkörperprothesen sinnvoll?  

Microsoft Academic Search

Zum Thema Schwellkörperimplantate haben auch in der Zeit von Sildenafil und anderen oral applizierbaren Medikamenten ihren festen Stellenwert in der Therapie der erektilen Dysfunktion (ED). Von 38 Patienten, die seit 1997 eine Schwellkörperprothesenimplantation nach präoperativ durchgeführter Kavernosographie und -metrie erhalten haben, waren 34 Patienten SKAT- und Sildenafil-Nonresponder, 4 Patienten hatten vor der Einführung von Sildenafil die Fortführung der Schwellkörperautoinjektionen oder

A. Al-Ateeqi; H. Sperling; G. Lümmen; H. Rübben

2000-01-01

273

Human von Willebrand factor gene and pseudogene: Structural analysis and differentiation by polymerase chain reaction  

Microsoft Academic Search

Structural analysis of the von Willebrand factor gene located on chromosome 12 is complicated by the presence of a partial unprocessed pseudogene on chromosome 22q11-13. The structures of the von Willebrand factor pseudogene and corresponding segment of the gene were determined, and methods were developed for the rapid differentiation of von Willebrand factor gene and pseudogene sequences. The pseudogene is

David J. Mancuso; Elodee A. Tuley; Lisa A. Westfield; Teresa L. Lester-Mancuso; J. M. Sorace; J. E. Sadler; M. M. Le Beau

1991-01-01

274

Über den Nachweis von Reduktionsorten mittels Tetrazol in Mundspeicheldrüsen und Pankreas des Meerschweinchens  

Microsoft Academic Search

Im ersten Teil der Untersuchung wurde die Brauchbarkeit der Supravitalfärbung mit TTC zur topischen Darstellung von Stoffwechselvorgängen untersucht, einmal hinsichtlich der Faktoren, die allgemein bei Supravitalfärbung von Bedeutung sind (Gefäßversorgung der Organe bei Verteilung des Farbstoffes auf dem Blutwege, Permeabilität, Diffusion und Fixierung des Farbstoffes im Gewebe), zum zweiten hinsichtlich der Abhängigkeit der Reduktion des TTC von den Stoffwechselvorgängen, wobei

Anton Stier

1952-01-01

275

Remarks on the continuous L^2-cohomology of von Neumann algebras  

Microsoft Academic Search

We prove that norm continuous derivations from a von Neumann algebra into the algebra of operators affiliated with its tensor square are automatically continuous for the strong operator topology as well. From this we rederive previously known computational results regarding the first continuous L^2-Betti number for von Neumann algebras, and furthermore prove that it vanishes whenever the von Neumann algebra

Vadim Alekseev; David Kyed

2011-01-01

276

A Remark on the structure of symmetric quantum dynamical semigroups on von Neumann algebras  

Microsoft Academic Search

We study the structure of the generator of a symmetric, conservative quantum dynamical semigroup with norm-bounded generator on a von Neumann algebra equipped with a faithful semifinite trace. For von Neumann algebras with abelian commutant (i.e. type I von Neumann algebras), we give a necessary and sufficient algebraic condition for the generator of such a semigroup to be written as

Sergio Albeverio; Debashish Goswami

2002-01-01

277

Quantitative evaluation of the utero-ovarian venous pattern in the adult human female cadaver with plastination  

Microsoft Academic Search

We described the anatomy of the utero-ovarian venous system in the adult postmenopausal female cadaver using casts and the\\u000a von Hagen’s plastination technique. To qualitatively and quantitatively evaluate the uterine vein, the utero-ovarian arcade,\\u000a the ovarian vein and the ramus communicans between left and right parametrium, we injected epoxy resin into the internal iliac\\u000a vein and artery and the ovarian

Mircea L. Pavkov; Jürgen Koebke; Hans-P. Notermans; Jost Brökelmann

2004-01-01

278

Biogenesis of Weibel-Palade bodies in von Willebrand's disease variants with impaired von Willebrand factor intrachain or interchain disulfide bond formation  

PubMed Central

Background Mutations of cysteine residues in von Willebrand factor are known to reduce the storage and secretion of this factor, thus leading to reduced antigen levels. However, one cysteine mutation, p.Cys2773Ser, has been found in patients with type 2A(IID) von Willebrand’s disease who have normal plasma levels of von Willebrand factor. We hypothesize that disruption of either intra- or interchain disulfide bonds by cysteine mutations in von Willebrand factor has different effects on the biogenesis of Weibel-Palade bodies. Design and Methods The effect of specific cysteine mutations that either disrupt intrachain (p.Cys1130Phe and p.Cys2671Tyr) or interchain (p.Cys2773Ser) disulfide bonds on storage and secretion of von Willebrand factor was studied by transient transfection of human embryonic kidney cell line 293. Upon expression of von Willebrand factor these cells formed endothelial Weibel-Palade body-like organelles called pseudo-Weibel-Palade bodies. Storage of von Willebrand factor was analyzed with both confocal immunofluorescence and electron microscopy. Regulated secretion of von Willebrand factor was induced by phorbol 12-myristate 13-acetate. Results p.Cys1130Phe and p.Cys2671Tyr reduced the storage of von Willebrand factor into pseudo-Weibel-Palade bodies with notable retention of von Willebrand factor in the endoplasmic reticulum, whereas p.Cys2773Ser-von Willebrand factor was stored normally. As expected, wild-type von Willebrand factor formed proteinaceous tubules that were seen under electron microscopy as longitudinal striations in pseudo-Weibel-Palade bodies. p.Cys2773Ser caused severe defects in von Willebrand factor multimerization but the factor formed normal tubules. Furthermore, the basal and regulated secretion of von Willebrand factor was drastically impaired by p.Cys1130Phe and p.Cys2671Tyr, but not by p.Cys2773Ser. Conclusions We postulate that natural mutations of cysteines involved in the formation of interchain disulfide bonds do not affect either the storage in Weibel-Palade bodies or secretion of von Willebrand factor, whereas mutations of cysteines forming intrachain disulfide bonds lead to reduced von Willebrand factor storage and secretion because the von Willebrand factor is retained in the endoplasmic reticulum.

Wang, Jiong-Wei; Groeneveld, Dafna J.; Cosemans, Guy; Dirven, Richard J.; Valentijn, Karine M.; Voorberg, Jan; Reitsma, Pieter H.; Eikenboom, Jeroen

2012-01-01

279

Conditional expectation and commutativity in von Neumann algebras  

Microsoft Academic Search

LetH be a Hilbert space,A the von Neumann algebra of all bounded operators onH,B a von Neumann subalgebra ofA, andw a bounded linear functional onA. The functionalw is said to commute withB?A ifw(AB)=w(BA) for allA?A. It is shown that the mapB?w (BAB) is a complex measure on the orthocomplemented partially ordered set of all orthogonal projections inB for everyA?A if

M. J. Maczy?ski

1977-01-01

280

Erkennen und Bewerten von Dysfunktionen und Schmerzphänomenen im kraniomandibulären System  

Microsoft Academic Search

Zusammenfassung  \\u000a Der logische Aufbau der Untersuchungssequenz erlaubt die volle Integration des Systems in die tägliche Praxis. Sie schafft\\u000a ein Maximum an diagnostischer Sicherheit. Dabei lebt die Sicherheit der Aussagen aus der Untersuchungskaskade von der Menge\\u000a und Qualität der von jedem einzelnen Arzt durchgeführten Untersuchungen und der darauf aufbauenden Therapie.\\u000a \\u000a \\u000a \\u000a Die genaue Differenzierung der Funktionsstörungen des kraniomandibulären Systems (CMS) in dento-\\/okklusogene,

S. Kopp; W. G. Sebald; G. Plato

2000-01-01

281

Von Pott-Trias und Schmorl-Knoten  

Microsoft Academic Search

Zusammenfassung  \\u000a Der Artikel gibt einen Überblick zur Geschichte der arkuären und angulären Kyphose unter besonderer Berücksichtigung der tuberkulösen\\u000a Spondylitis von den ersten Beschreibungen bis zum Beginn der tuberkulostatischen Therapie und der Kyphosis juvenilis Scheuermann.\\u000a Die diagnostischen und die therapeutischen Möglichkeiten werden in Abhängigkeit von der jeweiligen Zeit dargestellt.\\u000a \\u000a \\u000a \\u000a Ein weiterer Schwerpunkt ist der Diskussion der verschiedenen wissenschaftlichen Standpunkte gewidmet. Die

M. A. Rauschmann; B. Habermann; M. Engelhardt; G. Schwetlick

2001-01-01

282

Conical soft x-ray Von Hamos spectrometer  

NASA Astrophysics Data System (ADS)

The soft x-ray spectroscopy group has designed and implemented a unique form of the Von Hamos spectrometer. Von Hamos spectrometers are used to provide spectral information of laser produced plasmas, and commonly have a detector placed perpendicular to the focusing plane. Such a set up provides a large spectral range at high resolution, but does not allow for absolute intensity information. This new design places our CCD detector parallel to the focusing plane, allowing for the absolute calibration of the plasma source.

Harrison, Matthew; Ellsworth, John E.; Shevelko, Alexander; Knight, Larry V.

2006-10-01

283

Welche phonologische Arbeitsgedächtnisleistung trennt Kinder mit AVWS von unauffälligen Kindern?  

Microsoft Academic Search

Zusammenfassung\\u000a Hintergrund  Es sollten die Leistungen in verschiedenen phonologischen Arbeitsgedächtnisprüfungen von Kindern mit isolierten auditiven\\u000a Verarbeitungs- und Wahrnehmungsstörungen (AVWS) bzw. solchen mit AVWS bei Komorbidität verglichen und geprüft werden, welches\\u000a dieser Maße sie am besten von unauffälligen Kindern trennt.\\u000a \\u000a \\u000a \\u000a \\u000a Material und Methoden  Retrospektive Auswertung der Daten einer Krankenversorgungsforschungsbank. Das Behalten wurde durch das Nachsprechen standardisierter,\\u000a verbaler Sequenzen geprüft: Zahlen, Wörter (Einsilber); mehrsilbige

C. Kiese-Himmel

2011-01-01

284

An Accurate von Neumann's Law for Three-Dimensional Foams  

SciTech Connect

The diffusive coarsening of 2D soap froths is governed by von Neumann's law. A statistical version of this law for dry 3D foams has long been conjectured. A new derivation, based on a theorem by Minkowski, yields an explicit analytical von Neumann's law in 3D which is in very good agreement with detailed simulations and experiments. The average growth rate of a bubble with F faces is shown to be proportional to F{sup 1/2} for large F , in contrast to the conjectured linear dependence. Accounting for foam disorder in the model further improves the agreement with data.

Hilgenfeldt, Sascha; Kraynik, Andrew M.; Koehler, Stephan A.; Stone, Howard A.

2001-03-19

285

Henry Cavendish, Johann von Soldner, and the deflection of light  

NASA Astrophysics Data System (ADS)

The gravitational deflection of light based on Newtonian theory and the corpuscular model of light was calculated, but never published, around 1784 by Henry Cavendish, almost 20 years earlier than the first published calculation by Johann Georg von Soldner. The two results are slightly different because, while Cavendish treated a light ray emitted from infinity, von Soldner treated a light ray emitted from the surface of the gravitating body. At the first order of approximation, they agree with each other; both are one-half the value predicted by general relativity and confirmed by experiment.

Will, Clifford M.

1988-05-01

286

Diagnosis and classification of von Willebrand disease: a review of the differential utility of various functional von Willebrand factor assays.  

PubMed

von Willebrand disease (VWD) is considered to be the most common inherited bleeding disorder. VWD is diagnosed following a clinical and physical review, with personal and familial evidence of (primarily mucocutaneous) bleeding, and confirmed by laboratory testing. The latter typically entails initial plasma testing of factor VIII coagulant, von Willebrand factor (VWF) protein ('antigen') and VWF function which has classically been assessed using the ristocetin cofactor (VWF:RCo) assay. More recent attention has focussed on other functional VWF assays, such as collagen binding and so-called 'VWF activity' assays, as possible replacements to the VWF:RCo, or as supplementary tests of VWF 'function'. Additional laboratory testing can comprise a battery of confirmatory and VWD-type assisting assays, including VWF:multimer and von Willebrand factor VIII binding. This review aims to update knowledge of current VWD diagnostics with a particular emphasis on 'functional' VWF assays. PMID:21885953

Favaloro, Emmanuel J

2011-10-01

287

Quantitative metabolomics: a phantom?  

PubMed

'Mass specs are precise but biology is not!' is a frequently heard argument when quantitative experimental data do not fit into the overall picture. The problem with this opinion is that the significance of measured biological data becomes a matter of gut feeling. Doubtlessly, the measurement precision of modern mass spectrometers is far better than the reproducibility of biological experiments. However, precisely for this reason, technical reproduction of mass spectrometric measurements neither characterizes the whole experiment from cell cultivation to producing biological data nor says anything about systematic errors in the overall measurement procedure. Taking quantitative metabolomics as a fruitful example, we deal with the question of why it is so difficult to say something precise about imprecision in biology. PMID:24708998

Noack, Stephan; Wiechert, Wolfgang

2014-05-01

288

Isotopenuntersuchungen zur Wechselwirkung von Grund- und Oberflächenwasser in der Entstehungsphase von Bergbauseen  

Microsoft Academic Search

Kurzfassung  \\u000a \\u000a Die Umweltisotope \\u000a \\u000a 2\\u000a \\u000a H, \\u000a \\u000a 3\\u000a \\u000a H, \\u000a \\u000a 13\\u000a \\u000a C, \\u000a \\u000a 18\\u000a \\u000a O, \\u000a \\u000a 34\\u000a \\u000a S und \\u000a \\u000a 222\\u000a \\u000a Rn wurden verwendet, um Austauschbeziehungen innerhalb und zwischen Grund- und Seegewässern in der Anfangsphase der Herausbildung\\u000a der beiden Tagebauseen von Merseburg-Ost zu beschreiben. Mittels Tritium konnten Aufstiegspfade für stärker salzhaltige Liegendwässer\\u000a lokalisiert und deren Anteile am Seewasser abgeschätzt werden. Das Liegenwasser ist nach der Isotopenzusammensetzung

Rolf Trettin; Klaus Freyer; Gerhard Strauch; Hanns-Christian Treutler; Walter Gläßer

1999-01-01

289

Modern quantitative schlieren techniques  

NASA Astrophysics Data System (ADS)

Schlieren optical techniques have traditionally been used to qualitatively visualize refractive flowfields in transparent media. Modern schlieren optics, however, are increasingly focused on obtaining quantitative information such as temperature and density fields in a flow -- once the sole purview of interferometry -- without the need for coherent illumination. Quantitative data are obtained from schlieren images by integrating the measured refractive index gradient to obtain the refractive index field in an image. Ultimately this is converted to a density or temperature field using the Gladstone-Dale relationship, an equation of state, and geometry assumptions for the flowfield of interest. Several quantitative schlieren methods are reviewed here, including background-oriented schlieren (BOS), schlieren using a weak lens as a "standard," and "rainbow schlieren." Results are presented for the application of these techniques to measure density and temperature fields across a supersonic turbulent boundary layer and a low-speed free-convection boundary layer in air. Modern equipment, including digital cameras, LED light sources, and computer software that make this possible are also discussed.

Hargather, Michael; Settles, Gary

2010-11-01

290

Changes of von Willebrand Factor during Pregnancy in Women with and without von Willebrand Disease  

PubMed Central

Delivery in von Willebrand disease (VWD) represents a significant hemostatic challenge because of the variable pattern of changes observed during pregnancy of von Willebrand factor (VWF) and factor VIII (FVIII), the protein carried by VWF. Since a wide heterogeneity of phenotypes and of the underlying pathophysiological mechanisms is associated with this disorder, a prompt and careful evaluation of pregnant women with VWD is requested in order to plan the most appropriate treatment at time of parturition. VWF and FVIII increase significantly during pregnancy in normal women, already within the first trimester, reaching levels by far >100 U/dL by the time of parturition. Women with VWD, levels at baseline of VWF and FVIII >30 U/dL have us a high likelihood to achieve normal levels at the end of pregnancy; thus specific anti-hemorrhagic prophylaxis is seldom required. Women with basal level <20 U/dL usually have a poor increase since most of these women carry mutations associated with increased VWF clearance or are compound heterozygous for different VWF mutations; that prevent the achievement of satisfactory hemostatic levels. While women with mutations associated with increased clearance show a full, albeit transitory correction of their hemostatic deficiency after desmopressin administration, compound heterozygous need replacement therapy because they do not respond well to this agent. Patients with abnormal VWF:RCo/VWF:Ag ratio at baseline (e.g. <0.6), typically associated with type 2 VWD, maintain the abnormality throughout pregnancy and VWF:RCo usually does not attain safe levels ?50 U/dL. These women require replacement therapy with VWF-FVIII concentrates. Delayed post-partum bleeding may occur when replacement therapy is not continued for some days. Tranexamic acid may be useful at discharge to avoid excessive lochia.

Castaman, Giancarlo

2013-01-01

291

Screening for von Willebrand disease: contribution of an automated assay for von Willebrand factor activity.  

PubMed

Measuring von Willebrand factor (VWF) activity is essential to the diagnosis of von Willebrand disease (VWD). The VWF activity is usually assessed based on measurement of the ristocetin cofactor (VWF:RCo). However, that test is technically challenging and has high intra- and inter-assay variabilities. The HemosIL VWF activity (VWF:AC) is a fully automated assay, recently proposed as a good alternative to VWF:RCo for VWD diagnosis. This study was undertaken to assess this new method. First, the analytical performance of VWF:AC on an automated coagulo-meter (ACLTop) was determined, and then this new method was compared with VWF:RCo and the platelet function analyzer (PFA100) for 160 patients referred for VWD screening. The VWF:AC achieved acceptable precision with within-run and between-run coefficients of variation ranging from 2.3% to 14.1%, and linearity from 10% to 100%. Despite some marked differences between VWF:AC and VWF:RCo for 10 plasmas tested, their agreement for VWD diagnosis was good. The VWF:AC had sensitivity similar to that of PFA100 (close to 100%), but better specificity (97.7% vs. 66% or 60%, depending on the cartridge used). The good analytical performance, and the sensitivity and specificity of VWF:AC to detect VWF deficiency renders it a suitable method for VWD screening. Our findings support VWF:AC use for the diagnostic work-up of VWD, paying close attention to concomitant clinical signs and bleeding score, as recommended for VWD. PMID:21951857

Lasne, D; Dey, C; Dautzenberg, M-D; Cherqaoui, Z; Monge, F; Aouba, A; Torchet, M-F; Geloen, D; Landais, P; Rothschild, C

2012-05-01

292

Über die Milchsäureoxydation im Gehirn von Hühnern in Avitaminose B  

Microsoft Academic Search

Zusammenfassung Vergleichsweise wurden Oxydationsvorgänge am Gehirn von teils im normalen, teils im Hungerzustand und teils in B-Avitaminose sich befindenden Hühnern, und zwar getrennt am Großhirn, Lobi optici, Pendunculi cerebri und Medulla oblongata untersucht und festgestellt, daß bei Avitaminosehühnern, wenn der Hungerzustand durch Zwangsernährung beseitigt wird, die Oxydationsfähigkeit des Gehirns für Milchsäure sinkt, obwohl das gesamte Oxydationsvermögen dieses Organs unverändert bleibt.

P. E. Galvão; C. H. Florence

1934-01-01

293

Mikroableitungen einzelner zentraler Vestibularisneurone von Knochenfischen bei Statolithenreizen  

Microsoft Academic Search

1.Aus der Medulla oblongata und dem Kleinhirn (Valvula cerebelli) von Knochenfischen wurden mit Drahtelektroden Einzelneuronentladungen bei Statolithenreizen abgeleitet. Es fanden sich spezifische Reaktionen der Neurone auf seitliches Kippen der Tiere um ihre Längsachse.2.Die regelmäßige Ruheentladung der Neurone in Normallage des Fisches zeigt mit dem Kippwinkel in einer Richtung eine kontinuierliche Frequenzsteigerung, in der entgegengesetzten Richtung eine Frequenzabnahme. Jeder Lage des

Lore Schoen

1957-01-01

294

Dr. von Braun With a Model of a Launch Vehicle  

NASA Technical Reports Server (NTRS)

Dr. von Braun stands beside a model of the upper stage (Earth-returnable stage) of the three-stage launch vehicle built for the series of the motion picture productions of space flight produced by Walt Disney in the mid-1950's.

1950-01-01

295

rückverfolbarkeit von Lebensmitteln: Aktuelle Entwicklungen und Anforderungen an Informationstechnologien  

Microsoft Academic Search

Im Bereich der Rückverfolgbarkeit von Lebensmitteln sind verschiede- ne Strategien erkennbar, die unterschiedliche Anforderungen an die IT stellen. Während Unternehmen, die lediglich die Erfüllung der gesetzlichen Normen errei- chen wollen, nur mit geringem zusätzlichem Aufwand rechnen müssen, sehen sich Unternehmen, welche die Daten zur Risikominderung oder zur Erreichung eines Differenzierungsvorteils nutzen, mit deutlich höheren Anforderungen konfrontiert.

Ludwig Theuvsen; Thorsten Hollmann-hespos

2004-01-01

296

Ernst von Glasersfeld's Radical Constructivism and Truth as Disclosure  

ERIC Educational Resources Information Center

In this essay Clarence Joldersma explores radical constructivism through the work of its most well-known advocate, Ernst von Glasersfeld, who combines a sophisticated philosophical discussion of knowledge and truth with educational practices. Joldersma uses Joseph Rouse's work in philosophy of science to criticize the antirealism inherent in…

Joldersma, Clarence W.

2011-01-01

297

Von Neumann categories and extended $L^2$ cohomology  

Microsoft Academic Search

In this paper we suggest a new general formalism for studying the invariants of polyhedra and manifolds comming from the theory of von Neumann algebras. First, we examine generality in which one may apply the construction of the extended abelian category, which was suggested in the previous publications of the author, using the ideas of P.Freyd. This leads to the

Michael Farber

1996-01-01

298

Wernher von Braun: Reflections on His Contributions to Space Exploration  

NASA Technical Reports Server (NTRS)

In 1950, Dr. Wernher von Braun and approximately 100 of his team members came to Huntsville, Alabama, to begin work with the Army on what would later become America's historic space program. He would later serve as the first director of the Marshall Space Flight Center and led the development of the Saturn V launch vehicle that launched seven crewed American mission to the moon, as well as America s first space station, Skylab. Von Braun is best known for his team s technical achievements. He realized his dream of exploring outer space by helping place humans on the moon. His engineering and managerial talent during the Apollo era had contributed to a technological revolution. He was by all accounts a good engineer, but he was only one among many. What set Von Braun apart were his charisma, his vision, and his leadership skills. He inspired loyalty and dedication in the people around him. He understood the importance of communicating his vision to his team, to political and business leaders and the public. Today, the Marshall Center continues his vision by pursuing engineering and scientific projects that will continue to open space to exploration. This presentation will discuss Von Braun's impact on Huntsville, the Marshall Center, the nation and the world and look at his contributions in context of where world space exploration is today.

Goldman, Arthur E.

2012-01-01

299

Orientierung von Lasius fuliginosus Latr. an einer Gabelung der Geruchsspur  

Microsoft Academic Search

Zusammenfassung Das Aufspaltungsverhältnis der futtersuchenden Arbeiterinnen vonLasius fuliginosus an einer Gabelung der Geruchsspur wird im Laborversuch durch das Mengenverhältnis der auf die zwei Schenkel aufgetragenen Spursubstanz bestimmt. Auch im Freiland kann dieses Prinzip wirksam sein, wird jedoch bei erfahrenen Arbeiterinnen offenbar durch optische Orientierung überlappt.

W. Hangartner

1969-01-01

300

Relative tensor products for modules over von Neumann algebras  

Microsoft Academic Search

We give an overview of relative tensor products (RTPs) for von Neumann algebra modules. For background, we start with the categorical definition and go on to examine its algebraic formulation, which is applied to Morita equivalence and index. Then we consider the analytic construction, with particular emphasis on explaining why the RTP is not generally defined for every pair of

David Sherman

2003-01-01

301

Von Neuman Representations on Self-Dual Hilbert W* Moduli.  

National Technical Information Service (NTIS)

Von Neumann algebras M of bounded operators on self-dual Hilbert W* moduli H possessing a cyclic-separating element x-bar in H are considered. The close relation of them to certain real subspaces of H is established. Under the supposition that the underly...

M. Frank

1987-01-01

302

Abbildungen von Objekten in der Nähe rotierender Schwarzer Löcher  

Microsoft Academic Search

Der Autor beschäftigt sich in der vorliegenden Arbeit mit der Lichtausbreitung in der Nähe eines rotierenden Schwarzen Lochs und den daraus resultierenden Effekten für einen fernen Beobachter. Er beantwortet die Fragen, welches Bild der Beobachter theoretisch von einem um das Loch rotierenden Objekt gewinnen kann, und welchen spektralen Flußverlauf er mißt, wenn die Emissivität an der Objektoberfläche bekannt ist.

S. Viergutz

1993-01-01

303

Prüfung des Resistenzverhaltens von Kartoffelsorten gegenüber Fusarium coeruleum (Lib.) Sacc  

Microsoft Academic Search

Zwei Testverfahren für die Prüfung von Kartoffelsorten auf ihre Reaktion gegenüberFusarium coeruleum, einem Trockenfäuleerreger, wurden untersucht. Verfahren A (gleichmässig tiefe Knollenbeschädigung) berücksichtigt nur die physiologische Abwehrkraft. Verfahren B (mit Schlagpendel) schliesst auch die mechanische Widerstandsfähigkeit mit ein. Zwischen A und B sind die Unterschiede zum Teil erheblich. Mindestens 2 Testjahre sind für die einwandfreie Sortenbeurteiling erforderlich. Ein der Fäuleausdehnung in

E. Langerfeld

1979-01-01

304

q-supersymmetric generalization of von Neumann's theorem  

Microsoft Academic Search

Assuming that there exist operators which form an irreducible representation of the q-superoscillator algebra, it is proved that any two such representations are equivalent, related by a uniquely determined superunitary transformation. This provides with a q-supersymmetric generalization of the well-known uniqueness theorem of von Neumann for any finite number of degrees of freedom.

M. Chaichian; R. Gonzalez-Felipe; P. Presnajder

1993-01-01

305

on von Neumann Reflection of Shock Wave in Condensed matters  

Microsoft Academic Search

In the irregular reflection of shock waves in gas media, a kind of reflection phenomenon called the von Neumann reflection(vNR), has been being studied by experimental, theoretical and numerical techniques. Recently, for shock waves in condensed matter, such as in water, an alike irregular reflection phenomenon has also been observed in the experiment. In this paper, we present the results

Shigeru Itoh; Yoh Nadamitsu; Zhiyue Liu; Masahiro Fujita

1997-01-01

306

Die geologischen Ergebnisse der Salzbohrungen im Talbecken von Bad Reichenhall  

Microsoft Academic Search

Zusammenfassung  Im Talkessel von Bad Reichenhall sind 9 Bohrungen zur Erkundung der Salzlagerstätte niedergebracht worden. Gemeinsam mit den Ergebnissen neuer Kartierungsarbeiten haben diese Bohrungen die Kenntnisse zur Geologie dieses Kalkalpenabschnittes wesentlich erweitert.Die Salzlagerstätte besteht aus einem steil nach Süden einfallenden, in sich isoklinal verfalteten linsenförmigen Körper; er ist über 1200 m unter die heutige Talsohle zu verfolgen, der gesamte Tiefgang ist

Othmar Schauberger; Heinrich Zankl

1976-01-01

307

Ton, Geoden und Minerale des Barrême von Hoheneggelsen  

Microsoft Academic Search

Zusammenfassung  Der Ton wurde röntgenographisch, mikroskopisch und mit der Differentialthermoanalyse untersucht. Aus den Ergebnissen von Beobachtungen in der Natur und petrographischen Untersuchungen an den Geoden können Einzelheiten über ihre Entstehung abgeleitet werden. Insbesondere wird gezeigt, daß aus dem Karbonatgehalt der Geoden der Wassergehalt des Tones zur Zeit der Bildung der Geoden auf einfache Weise berechnet werden kann. Die Minerale in den

F. Lippmann

1955-01-01

308

Extrusion von ein- und mehrlumigen Katheterschläuchen aus thermoplastischen Kunststoffen  

NASA Astrophysics Data System (ADS)

In der Fertigung von medizinischen Katheterschläuchen werden thermoplastisch verarbeitbare Materialien wie z. B. Pebax, Polyamid, Polyurethan, Polyethylen oder Weich-PVC eingesetzt. Sämtliche zum Einsatz kommenden Materialien müssen für den medizinischen Einsatz zugelassen sein. Sie müssen in ihrer Zusammensetzung physiologisch unbedenklich sein.

Wahl, Helmut

309

Extrusion von ein- und mehrlumigen Katheterschläuchen aus thermoplastischen Kunststoffen  

Microsoft Academic Search

In der Fertigung von medizinischen Katheterschläuchen werden thermoplastisch verarbeitbare Materialien wie z. B. Pebax, Polyamid, Polyurethan, Polyethylen oder Weich-PVC eingesetzt. Sämtliche zum Einsatz kommenden Materialien müssen für den medizinischen Einsatz zugelassen sein. Sie müssen in ihrer Zusammensetzung physiologisch unbedenklich sein.

Helmut Wahl

2009-01-01

310

Die Verhütung von Erschöpfungszuständen des Herzens durch Digitalissubstanzen  

Microsoft Academic Search

Zusammenfassung Durch erschöpfendes Schwimmen bzw. Lauftraining wird bei Ratten eine Herzund Nebennierenhypertrophie erzeugt. Durch Injektion von g-Strophanthin bzw. k-Strophanthin jeweils vor Beginn des Trainings ist es möglich, die Hypertrophie des Herzens und der Nebennieren zu vermindern. Daraus ist zu schließen, daß Strophanthin die Leistung des Herzens so verbessert, daß einer Erschöpfung, d. h. relativen Insuffizienz vorgebeugt wird.

Gustav Kuschinsky

1947-01-01

311

Toward a dataflow\\/von Neumann hybrid architecture  

Microsoft Academic Search

Dataflow architectures offer the ability to trade program level parallelism in order to overcome machine level latency. Dataflow further offers a uniform synchronization paradigm, representing one end of a spectrum wherein the unit of scheduling is a single instruction. At the opposite extreme are the von Neumann architectures which schedule on a task, or process, basis.This paper examines the spectrum

Robert A. Iannucci

1988-01-01

312

Unitary orbits of normal operators in von Neumann algebras  

Microsoft Academic Search

The starting points for this paper are simple descriptions of the norm and strong* closures of the unitary orbit of a normal operator in a von Neumann algebra. The statements are in terms of spectral data and do not depend on the type or cardinality of the algebra. We relate this to several known results and derive some consequences, of

David Sherman

2005-01-01

313

Untersuchungen über die Verträglichkeit von 5Hydroxymethylfurfural (HMF)  

Microsoft Academic Search

Zusammenfassung Männliche Sprague-Dawley Ratten erhielten 250 mg\\/kg 5-Hydroxymethylfurfural (HMF) 40 Wochen hindurch verfüttert. Bezügl. Gewichtszunahme, Futterverzehr, Futter-Efficiency und erreichtem Endgewicht der Tiere ergaben sich keine signifikanten Unterschiede gegenüber Kontrolltieren, die kein HMF erhalten hatten. Auch die histologische Untersuchung von Leber, Nieren, Herz, Milz und Testes ergab keine Unterschiede zwischen den beiden Gruppen.

K. Lang; W. Kieckebusch; K. H. Bässler; W. Griem; G. Czok

1970-01-01

314

Dr. Wernher Von Braun near the mobile launcher.  

NASA Technical Reports Server (NTRS)

Dr. George Mueller, NASA associate administrator for manned space flight, and Dr. Wernher Von Braun (right), director of the Marshall Space Flight Center, are seen near the mobile launcher carrying a 363 foot tall Saturn V space launch vehicle as the rocket is rolled from the vehicle assembly building at KSC for its three mile trip to the launch pad.

1999-01-01

315

Dr. Wernher Von Braun with Congressman Gerald R. fod  

NASA Technical Reports Server (NTRS)

On a visit to the Marshall Space Flight Center in April, 1964, Congressman Gerald R. Ford, Jr. Republican of Michigan, was warmly greeted by Dr. Wernher Von Braun, Marshall Space Flight Center director. Ford, along with two other congressmen, visited the center for a briefing on the Saturn program and for a tour of the facilities.

1999-01-01

316

Dr. von Braun at the Apollo 14 Launch  

NASA Technical Reports Server (NTRS)

Dr. Wernher von Braun, NASA Deputy Associate Administrator for Future Programs, uses binoculars to monitor data on the closed-circuit TV screen in the Firing Room of the Launch Control Center at Kennedy Space Center (KSC) during the final preparation for the Apollo 14 launch.

1971-01-01

317

Analytical diagnosis of soil pollution with heavy metals  

Microsoft Academic Search

Die Bestimmung einer Bodenverunreinigung hängt wesentlich von der geeigneten Probenvorbehandlung ab und weniger von der rein analytischen Methode. Eine Gesamtanalyse gibt Auskunft über eine mögliche Anreicherung von Schwermetallen, ist aber im allgemeinen und für die meisten Elemente nicht ausreichend zur Erkennung der biologischen Wirkung und muß durch zusätzliche chemische Analysen zur Spezifizierung der chemischen Form und der Mobilität der Verunreinigungen

A. Cottenie; M. Verloo

1984-01-01

318

Changes in von Willebrand factor and ADAMTS13 during IVF.  

PubMed

During IVF, circulating estradiol concentrations are strongly increased, and this may have direct effects on hemostasis. Elevated von Willebrand factor levels represent an important risk factor for arterial and venous thrombosis. ADAMTS13, also known as von Willebrand factor-cleaving protease, has an important regulatory function of von Willebrand factor but has not been studied during IVF. Blood was sampled from 31 women at maximal downregulation of estradiol synthesis using gonadotropin-releasing hormone analogues and during high-level stimulation of estradiol synthesis using follicle-stimulating hormone during the first phase of IVF. Von Willebrand factor antigen, von Willebrand factor ristocetin cofactor activity, factor VIII and ADAMTS13 antigen and activity levels in plasma were determined at the time of downregulation and at high-level stimulation. Estradiol increased from a mean of 154 pg/ml at downregulation to 5889 pg/ml at high-level stimulation (range 1620-19 500 pg/ml). Factor VIII increased from 0.96 ± 0.34 to 1.26 ± 0.41 kIU/l (P < 0.001). Von Willebrand factor antigen and activity increased from 0.75 ± 0.22 to 1.06 ± 0.40 kIU/l (P < 0.001) and from 0.83 ± 0.26 to 1.24 ± 0.48 kIU/l (P < 0.001), respectively. ADAMTS13 antigen decreased from 72.2 ± 13.5 to 67.9 ± 9.9% (P < 0.05, P = 0.01) and ADAMTS13 activity from 88.6 ± 18.3 to 80.8 ± 15.7% (P < 0.01). The increments in estradiol and factor VIII during IVF were paralleled by an increase in von Willebrand factor antigen and activity, and a decrease in circulating ADAMTS13 antigen and activity, respectively. This could in part explain why these patients have an increased risk of thrombotic events. PMID:21192251

Westerlund, Eli; Antovic, Aleksandra; Hovatta, Outi; Eberg, Karin P; Blombäck, Margareta; Wallén, Håkan; Henriksson, Peter

2011-03-01

319

Quantitative molecular methods in virology  

Microsoft Academic Search

Summary During the past few years, significant technical effort was made to develop molecular methods for the absolute quantitation of nucleic acids in biological samples. In virology, semi-quantitative and quantitative techniques of different principle, complexity, and reliability were designed, optimized, and applied in basic and clinical researches. The principal data obtained in successful pilot applications in vivo are reported in

M. Clementi; S. Menzo; A. Manzin; P. Bagnarelli

1995-01-01

320

Expression of abnormal von Willebrand factor by endothelial cells from a patient with type IIA von Willebrand disease.  

PubMed Central

Studies were conducted to characterize the biosynthesis of von Willebrand factor (vWf) by cultured endothelial cells (EC) derived from the umbilical vein of a patient with type IIA von Willebrand disease. The patient's EC, compared with those from normal individuals, produced vWf that had decreased amounts of large multimers and an increase in rapidly migrating satellite species, features characteristic of plasma vWf from patients with type IIA von Willebrand disease. The type IIA EC did produce a full spectrum of vWf multimers in both cell lysates and postculture medium, although the relative amounts of the largest species were decreased. The large multimers were degraded in conjunction with the appearance of rapidly migrating satellites that contained approximately equal to 170-kDa proteolytic fragments, suggesting that this patient's functional defect is due to abnormal proteolysis and not to a primary failure of vWf subunit oligomerization. Moreover, the observed degradation appears to result from an abnormal vWf molecule and not elevated protease levels. These results suggest that this patient's von Willebrand disease phenotype is caused by increased proteolytic sensitivity of his vWf protein. Images

Levene, R B; Booyse, F M; Chediak, J; Zimmerman, T S; Livingston, D M; Lynch, D C

1987-01-01

321

Quantitative Hyperspectral Reflectance Imaging  

PubMed Central

Hyperspectral imaging is a non-destructive optical analysis technique that can for instance be used to obtain information from cultural heritage objects unavailable with conventional colour or multi-spectral photography. This technique can be used to distinguish and recognize materials, to enhance the visibility of faint or obscured features, to detect signs of degradation and study the effect of environmental conditions on the object. We describe the basic concept, working principles, construction and performance of a laboratory instrument specifically developed for the analysis of historical documents. The instrument measures calibrated spectral reflectance images at 70 wavelengths ranging from 365 to 1100 nm (near-ultraviolet, visible and near-infrared). By using a wavelength tunable narrow-bandwidth light-source, the light energy used to illuminate the measured object is minimal, so that any light-induced degradation can be excluded. Basic analysis of the hyperspectral data includes a qualitative comparison of the spectral images and the extraction of quantitative data such as mean spectral reflectance curves and statistical information from user-defined regions-of-interest. More sophisticated mathematical feature extraction and classification techniques can be used to map areas on the document, where different types of ink had been applied or where one ink shows various degrees of degradation. The developed quantitative hyperspectral imager is currently in use by the Nationaal Archief (National Archives of The Netherlands) to study degradation effects of artificial samples and original documents, exposed in their permanent exhibition area or stored in their deposit rooms.

Klein, Marvin E.; Aalderink, Bernard J.; Padoan, Roberto; de Bruin, Gerrit; Steemers, Ted A.G.

2008-01-01

322

Von Willebrand's disease with spontaneous platelet aggregation induced by an abnormal plasma von Willebrand factor.  

PubMed Central

We have investigated and characterized the abnormalities in four unrelated patients with von Willebrand's disease (vWd) who have (a) enhanced ristocetin-induced platelet aggregation (RIPA) at low ristocetin concentrations, (b) absence of the largest plasma von Willebrand factor (vWf) multimers, and (c) thrombocytopenia. The platelet-rich plasma of these patients aggregates spontaneously without the addition of any agonists. When isolated normal platelets are resuspended in patient plasma spontaneous aggregation occurs; however, the patients' plasmas did not induce platelet aggregation of normal washed formalinized platelets. When the patients' platelets are suspended in normal plasma, spontaneous aggregation is not observed. The spontaneous platelet aggregation (SPA) is associated with dense granule secretion as measured by ATP release and alpha granule release as measured by beta-thromboglobulin and platelet factor 4 release. The SPA is totally inhibited by 5 mM EDTA, prostaglandin I2, and dibutryl cyclic AMP, while it is only partially inhibited by 1 mM EDTA, acetylsalicylic acid, or apyrase. A monoclonal antibody directed against glycoprotein Ib (GPIb) and/or a monoclonal antibody against the glycoprotein IIb/IIIa (GPIIb/IIIa) complex totally inhibits the SPA. The vWf was isolated from the plasma of one of these patients. The purified vWf induced platelet aggregation of normal platelets resuspended in either normal or severe vWd plasma, but the vWf did not induce platelet aggregation of normal platelets resuspended in afibrinognemic plasma. Sialic acid and galactose quantification of the patient's vWf revealed approximately a 50% reduction compared with normal vWf. These studies indicate that a form of vWd exists, which is characterized by SPA that is induced by the abnormal plasma vWf. The SPA is dependent on the presence of plasma fibrinogen, and the availability of the GPIb and the GPIIb/IIIa complex. In this variant form of vWd the abnormal vWf causes enhanced RIPA, SPA, and thrombocytopenia. Images

Grainick, H R; Williams, S B; McKeown, L P; Rick, M E; Maisonneuve, P; Jenneau, C; Sultan, Y

1985-01-01

323

Clinical Features and Types of Von Willebrand Disease in Women with Menorrhagia Referred to Hematology Clinic of Kermanshah  

PubMed Central

Menorrhagia is the most common symptom that is experienced by women with bleeding disorders. Von Willebrand disease (VWD) is the most common congenital human bleeding disorder that is manifested as a quantitative deficiency in Von Willebrand factor (VWF) or dysfunction of this factor. The frequency of VWD is similar in both men and women. However, VWD is more readily detected in women due to the presence of severe bleeding associated with menstrual cycles and childbirth. The present study was carried out to find the frequency of VWD, its types, and clinical features of the disease among women with menorrhagia who referred to the Hematology Clinic of the Kermanshah University of Medical Sciences. The study comprised 482 women with menorrhagia. After excluding patients with confounding factors, 56 (11.6%) patients were evaluated for inherited bleeding disorders. We detected 31 (55.3%) patients with VWD. Type 3 of VWD was the most frequent subtype (45.2%) followed in frequency by type 2 (32.3%), and type 1 (22.5%). In conclusion, our study indicated that menorrhagia can be the first symptom of VWD. Therefore, rare coagulation disorders should be considered in women with idiopathic menorrhagia, particularly in regions with high rates of consanguinity.

Payandeh, Mehrdad; Rahimi, Zohreh; Kansestani, Atefeh Nasir; Hemmati, Shahrooz; Aleyasin, Mahnaz; Zare, Mohammad Erfan; Nouri, Zohreh; Hashemian, Amir Hossein; Gohardehi, Farzad

2013-01-01

324

Zelltyp-spezifische Mikroanalyse von Arabidopsis thaliana-Blättern  

NASA Astrophysics Data System (ADS)

Im ersten Teil der Arbeit wurden Strategien zur Analyse von Transkripten erarbeitet. Die ersten Versuche zielten darauf ab, in mit Glaskapillaren genommenen Einzelzellproben verschiedener Gewebeschichten RT-PCR durchzuführen, um spezifische Transkripte nachweisen zu können. Dies gelang für eine Reihe von Genen aus verschiedenen Pflanzenspezies. Dabei konnten sowohl Transkripte stark wie auch schwach exprimierter Gene nachgewiesen werden. Für die Erstellung von Gewebe-spezifischen Expressionsprofilen war es notwendig, die in vereinigten Zellproben enthaltene mRNA zunächst zu amplifizieren, um eine ausreichende Menge für Arrayhybridisierungen zu erhalten. Vor der Vermehrung wurde die mRNA revers transkribiert. Es wurden daran anschließend verschiedene Amplifikationsstrategien getestet: Die neben Tailing, Adapterligation und anderen PCR-basierenden Protokollen getestete Arbitrary-PCR hat sich in dieser Arbeit als einfache und einzige Methode herausgestellt, die mit so geringen cDNA-Mengen reproduzierbar arbeitet. Durch Gewebe-spezifische Array-hybridisierungen mit der so amplifizierten RNA konnten schon bekannte Expressionsmuster verschiedener Gene, vornehmlich solcher, die an der Photosynthese beteiligt sind, beobachtet werden. Es wurden aber auch eine ganze Reihe neuer offensichtlich Gewebe-spezifisch exprimierter Gene gefunden. Exemplarisch für die differentiell exprimierten Gene konnte das durch Arrayhybridisierungen gefundene Expressionsmuster der kleinen Untereinheit von Rubisco verifiziert werden. Hierzu wurden Methoden zum Gewebe-spezifischen Northernblot sowie semiquantitativer und Echtzeit-Einzelzell-RT-PCR entwickelt. Im zweiten Teil der Arbeit wurden Methoden zur Analyse von Metaboliten einschließlich anorganischer Ionen verwendet. Es stellte sich heraus, daß die multiparallele Methode der Gaschromatographie-Massenspektrometrie keine geeignete Methode für die Analyse selbst vieler vereinigter Zellinhalte ist. Daher wurde auf Kapillarelektrophorese zurückgegriffen. Eine Methode, die mit sehr kleinen Probenvolumina auskommt, eine hohe Trennung erzielt und zudem extrem geringe Detektionslimits besitzt. Die Analyse von Kohlenhydraten und Anionen erfordert eine weitere Optimierung. Über UV-Detektion konnte die K+-Konzentration in verschiedenen Geweben von A. thaliana bestimmt werden. Sie lag in Epidermis und Mesophyll mit ca. 25 mM unterhalb der für andere Pflanzenspezies (Solanum tuberosum und Hordeum vulgare) publizierten Konzentration. Weiter konnte gezeigt werden, daß zwölf freie Aminosäuren mittels einer auf Kapillarelektrophorese basierenden Methode in vereinigten Zellproben von Cucurbita maxima identifiziert werden konnten. Die Übertragung der Methode auf A. thaliana-Proben muß jedoch weiter optimiert werden, da die Sensitivität selbst bei Laser induzierter Fluoreszenz-Detektion nicht ausreichte. Im dritten und letzten Teil der Arbeit wurde eine Methode entwickelt, die die Analyse bekannter wie unbekannter Proteine in Gewebe-spezifischen Proben ermöglicht. Hierzu wurde zur Probennahme mittels mechanischer Mikrodissektion eine alternative Methode zur Laser Capture Microdissection verwendet, um aus eingebetteten Gewebeschnitten distinkte Bereiche herauszuschneiden und somit homogenes Gewebe anzureichern. Aus diesem konnten die Proteine extrahiert und über Polyacrylamidgelelektrophorese separariert werden. Banden konnten ausgeschnitten, tryptisch verdaut und massenspektrometrisch die Primärsequenz der Peptidfragmente bestimmt werden. So konnten als Hauptproteine im Mesophyll die große Untereinheit von Rubisco sowie ein Chlorophyll bindendes Protein gefunden werden. Die in dieser Arbeit entwickelten und auf die Modellpflanze Arabidopsis thaliana angewandten Einzelzellanalysetechniken erlauben es in Zukunft, physiologische Prozesse besser sowohl räumlich als auch zeitlich aufzulösen. Dies wird zu einem detaillierteren Verständnis mannigfaltiger Vorgänge wie Zell-Zell-Kommunikation, Signalweiterleitung oder Pflanzen-Pathogen-Interaktionen führen. The subject of this thesis was the analys

Brandt, Stephan Peter

2002-04-01

325

Automated Quantitative Planetary Measurements  

NASA Astrophysics Data System (ADS)

Despite numerous attempts to automate the process of analysing planetary images, none have been widely adopted. Instead, some researchers prefer to out-source large scale processing tasks to Citizen Science projects [1]. We believe that the lack of uptake in fully automated methods is not due to performance levels, but the omission of an error theory capable of providing measurements within predictable accuracies. Here, we outline our work towards a flexible pattern recognition system for extracting scientifically useful quantitative measurements from planetary images, providing maximum likelihood measurement estimates accompanied by clear error predictions (in the form of measurement covariances) and a goodness-of-fit indicator. We include encouraging results from Monte-Carlo data and synthetic Martian images derived from HiRISE [2] datasets.

Tar, P. D.; Thacker, N. A.; Gilmour, J. D.; Jones, M. A.

2013-09-01

326

You Call That Quantitative?  

PubMed Central

Any reasonably modern fluorescence microscope can produce beautiful images of your cells and tissues without too much effort. But would you believe me if I told you that up to half of the images taken on our microscopes are essentially unquantifiable!? Lurking behind those colourful facades are: Lamp/ laser intensity fluctuations (as bad as 20% in a 3-hr session!)Non-uniform illumination across the field-of view (15–30% variations!)Uncorrected background and bleedthroughDark craters on camera surfacesPoor shutter control, leading to varying degrees of photobleaching Despite the fact that these (and other) issues are surprisingly widespread, users of these instruments are blissfully unaware of any problems and will likely go on to analyze the resulting images. I'll present several Case Studies that illustrate the extent of these problems, and then I'll suggest 7 specific steps that users can follow to ensure they get quantitative data from their microscope images.

Jonkman, James

2013-01-01

327

Understanding quantitative genetic variation.  

PubMed

Until recently, it was impracticable to identify the genes that are responsible for variation in continuous traits, or to directly observe the effects of their different alleles. Now, the abundance of genetic markers has made it possible to identify quantitative trait loci (QTL)--the regions of a chromosome or, ideally, individual sequence variants that are responsible for trait variation. What kind of QTL do we expect to find and what can our observations of QTL tell us about how organisms evolve? The key to understanding the evolutionary significance of QTL is to understand the nature of inherited variation, not in the immediate mechanistic sense of how genes influence phenotype, but, rather, to know what evolutionary forces maintain genetic variability. PMID:11823787

Barton, N H; Keightley, P D

2002-01-01

328

Einfache Decarbonylierungen und stereoselektive Oxidationen von Cyclohexadienen und Cyclohexenen  

NASA Astrophysics Data System (ADS)

Zusammenfassend konnte im Rahmen dieser Arbeit das Synthesepotential von Cyclohexadienen und Cyclohexenen deutlich erweitert werden. Die Darstellung der 1-Alkylcyclohexa-2,5-dien-1-carbonsäuren erfolgte mittels Birch-Reduktion in flüssigem Ammoniak und anschließender Umsetzung der intermediär entstehenden Dianionen mit Alkylhalogeniden. So konnte ausgehend von verschiedenen Benzoesäurederivaten eine Reihe interessanter Cyclohexadiene in sehr guten Ausbeuten synthetisiert werden. Erstmals gelangen säurekatalysierte Decarbonylierungen von Cyclohexadiencarbonsäuren, was die einfache Synthese substituierter Aromaten in ausgezeichneten Ausbeuten ermöglichte. In dieser Arbeit wird der Reaktionsmechanismus vorgestellt, welcher durch den Nachweis von Kohlenmonoxid in der Gasphase der Reaktionslösung durch IR-Spektroskopie untermauert wird. Bei der säurekatalysierten Umsetzung von 3-alkylsubstituierten Cyclohexadien-carbonsäuren entstanden neben den erwarteten Aromaten Lactone in ca. 50% Ausbeute. Schließlich zeigen die untersuchten Singulettsauerstoff-En-Reaktionen, der im ersten Teil dargestellten Cyclohexadiene und Lactone, durchweg hohe Regioselektivitäten und lieferten durch elektrostatische Wechselwirkungen und konformative Effekte zum Teil sehr gute Diastereoselektivitäten. Die auxiliarkontrollierte Photooxygenierungen von Cyclohexenon welches mit verschiedenen Weinsäureestern ketalisiert wurde, zeigten jedoch keine bevorzugte p-Facialität des Singulettsauerstoffs. In this dissertation thesis it was possible to extend the synthetical potential of cyclohexadienes and cyclohexenes with partially newly developed and very efficient synthetic pathways. The alkylcyclohexadiene carboxylic acids were synthesized in good yields via well known Birch-reduction procedure in liquid ammonia from a broad variety of substituted benzoic acid derivatives. A wide range of alkylhalides were subsequently added to the resulting dianion. We were able to decarbonylize the cyclohexadienes through acid catalyses, which leads to ipso-substituted aromatics in excellent yields. The study presents the postulated mechanism, which is supported by the proof of carbon monoxide in the gas phase of the reactionmixture with IR-spectroscopy. When 3-alkylsubstituted cyclohexadiene carboxylic acids were subjected to the acid catalyses they gave lactones in up to 50% yield as side products of the aromatization product.The cyclohexadienes and lactones were used as substrates in singlet oxygen-en-reactions with photochemically induced singulet oxygen. The products showed high regioselectivitiy and partially high diastereoselectivity which is caused by electrostatic interaction and conformativ effects of the reaction intermediates. Experiments to induce auxiliary controlled photooxygenations of cyclohexenones, which were ketalysed with different chiral tartaric acid esters leaded to poor diastereoselectivity and a diverse mixture of isomers.

Vorndran, Katja Marianne

2002-01-01

329

Autosomal dominant von Willebrand disease type 2M.  

PubMed

von Willebrand disease (VWD) type 2M is a distinct entity and clearly differs from type 1. The genotype-phenotype correlation for cases with ristocetin cofactor activity (RCo)/antigen (Ag) ratios <0.60 is clear, whereas the von Willebrand factor (VWF):collagen binding (CB)/VWF:Ag ratio is normal in VWD 2M. Typical laboratory features of VWD type 2 M are decreased ristocetin-induced platelet aggregation in the presence of a normal or near normal VWF multimeric pattern on a low-resolution agarose gel, a poor response to desmopressin (DDAVP) of VWF:RCo, and a good response of both VWF:CB and VWF:Ag to DDAVP. The phenotypic definition of VWD type 2M may need to be more stringent and should be the subject of an international standardization initiative. PMID:19506360

Hermans, Cedric; Batlle, Javier

2009-01-01

330

Diagnosis of von Willebrand disease in South Island, New Zealand.  

PubMed

New Zealand is a small country of two islands and 4 million people, of which 1 million reside in the South Island. Canterbury Health Laboratories provides laboratory services to the whole of South Island and lower parts of North Island. There are 155 Von Willebrand disease (VWD) patients in our South Island database, of which 17 have type 2 and 3 have type 3 VWD. A brief overview of diagnostic services for VWD being followed in our region is detailed in this article. We strive continually to advance the repertoire of diagnostic tests. We also present an analysis of our experience with a flow-based functional Von Willebrand factor assay. The VWD patients are managed by hemostasis team members, who also provide screening and educational input to affected families. The Haemophilia Foundation of New Zealand is an active patient support group providing education and support both directed individually and in the group setting, through residential educational camps. PMID:22102199

Rajagopal, Rajeev; Smith, Mark P

2011-07-01

331

Fluctuation of magnetic induction in von Kármán swirling flows  

NASA Astrophysics Data System (ADS)

Studies of magnetic induction in von Kármán swirling flows have so far linked the time-averaged induced magnetic field to the structure of the mean flow. They have evidenced the Omega and Parker mechanism generated, respectively, by the flow differential rotation and helicity, which underly the Dudley and James [N. L. Dudley and R. W. James, Proc. R. Soc. London, Ser. A 425, 407 (1989)] dynamos. Using an array of Hall probes we study here the dynamical regime. In the experimental flow, turbulence is fully developed and large fluctuations are observed in the magnetic induction processes. We find that the large scale turbulent fluctuations have different characteristics when induction results from the differential rotation or from the dynamics of the stagnation point in the midplane of the von Kármán flow. Symmetry considerations indicate that the dynamical flow spends half of its time away from the time-averaged structure. The consequences of these observations for dynamo experiments are discussed.

Volk, Romain; Odier, Philippe; Pinton, Jean-François

2006-08-01

332

The molecular characterization of von Willebrand disease: Good in parts  

PubMed Central

Summary Since the cloning of the gene that encodes von Willebrand factor (VWF), 27 years ago, significant progress has been made in our understanding of the molecular basis of the most common inherited bleeding disorder, von Willebrand disease (VWD). The molecular pathology of this condition represents a range of genetic mechanisms, some of which are now very well characterized, and others that are still under investigation. In general, our knowledge of the molecular basis of type 2 and 3 VWD is now well advanced, and in some instances this information is being used to enhance clinical management. In contrast, our understanding of the molecular pathogenesis of the most common form of VWD, type 1 disease, is still at an early stage, with preliminary evidence that this phenotype involves a complex interplay between environmental factors and the influence of genetic variability both within and outside of the VWF locus.

James, P.D.; Lillicrap, D.

2014-01-01

333

Eine FPAA-Architektur zur rekonfigurierbaren Instantiierung von zeitkontinuierlichen Analogfiltern  

NASA Astrophysics Data System (ADS)

Im Folgenden wird eine neue Methodik von FPAAs (Field Programmable Analog Arrays) gezeigt, die speziell für die Instantiierung von zeitkontinuierlichen (continuous-time, CT) Analogfiltern in Hardware entwickelt wurde. Die Chiptopologie beinhaltet 17 digital konfigurierbare analoge Blöcke (configurable analog blocks, CABs), die durch ein hexagonales Netzwerk miteinander verbunden sind. Jeder CAB ist aus einstellbaren Gm-C Integratoren aufgebaut, welche das analoge Signal sowohl formen und seinen Weg durch die Matrix festlegen, gleichzeitig aber auch die Grundbausteine für zeitkontinuierliche Hochfrequenzfilter darstellen. Intelligente Pufferspeicher für die Ein-/Ausgänge (IO-buffer) garantieren die Rekonfigurierung der Matrix mit minimaler Störung des kontinuierlichen Analogsignals. Die Architektur wird als Hardwareplattform für beliebige Schaltungen, welche aus einer gegebenen Anzahl an Gm-C-Zellen bestehen, eingeführt und verifiziert bevor eine exemplarische Instantiierung eines Butterworth Filters 4. Ordnung in Biquad Anordnung gezeigt wird.

Becker, J.; Manoli, Y.

2005-05-01

334

Vergleichende In-vitro-Untersuchung von zwei Verfahren zur elektrischen Widerstandsmessung an nicht kavitierten Okklusalflächen  

Microsoft Academic Search

Die vorliegende In-vitro-Untersuchung zielte auf den Vergleich der Messwertreproduzierbarkeit und diagnostischen Güte von zwei Verfahren zur elektrischen Widerstandsmessung (ECM III; Cariometer 800, CRM) zur Okklusalkaries-Diagnostik ab. In die Untersuchung wurden 117 Weisheitszähne mit nicht kavitierten Okklusalflächen einbezogen. Die Zähne wurden von 4 Untersu- chern mit dem ECM-Gerät (Lode Diagnostics, Niederlande) und von 6 Untersuchern mit dem CRM-Gerät unabhängig voneinan- der

J. Kühnisch; M. Tabatabaie; G. Viergutz; S. Zraiki; G. Hetzer; L. Stösser; R. Heinrich-Weltzien

335

Untersuchungen zur Blattlausübertragbarkeit von Kartoffel-M-und-S-Virus  

Microsoft Academic Search

Übertragungsversuche mitMyzus persicae vonSolanum demissum aufS. demissum zeigten, daß das Kartoffel-M-Virus dem nicht-persistenten Übertragungstyp zugeordnet werden muß, und zwar ähnlich dem Kartoffel-Y-Virus, wie Parallel-versuche ergaben. Verschiedene M-Virusstämme unterschieden sich dabei erheblich in ihrer Übertragbarkeit. So konnten mit dem Stamm M 22 1 durchM. persicae 82% der Testpflanzen infiziert werden, mit dem Stamm D 1102 auf gleiche Weise jedoch nur etwa

O. Bode; H. L. Weidemann

1971-01-01

336

Value-Pricing-Initiative bei Alstom — Kommerzialisierung von Wettbewerbsvorteilen  

Microsoft Academic Search

Zusammenfassung  \\u000a Mit Value Pricing richtet das Energie- und Transportunternehmen Alstom seinen Pricing-Prozess systematisch auf Kundenorientierung\\u000a aus. Inzwischen stärkt die neue Pricing-Strategie die finanzielle Performance von Alstom — und scheint auch mit Blick auf Preisfairness\\u000a und in der gegenwärtigen Wirtschaftskrise zu bestehen. Wie die Umsetzung einer Value-Pricing-Strategie in einem Industriegüterunternehmen\\u000a aussehen kann, zeigt dieser Praxisreport.

Patrik A. Meier; Pascal Bula

2009-01-01

337

Ursula von der Leyen – Seiteneinsteigerin in zweiter Generation  

Microsoft Academic Search

„Supermutterpowertochter“, „Mutter des Humanvermögens“, respektive „der Nation“, „Familienrevolutionärin“ – so lauteten einige\\u000a der Artikelüberschriften zu Ursula v. d. Leyen von tazüber Spiegel bis zur Frankfurter Allgemeinen.1 Keine Frage also – diese Frau weckt das Interesse. Als Angela Merkel ihr Kabinett präsentierte, zog kaum eine Person mehr\\u000a Aufmerksamkeit auf sich als die neue Bundesministerin für Familie, Senioren, Frauen und Jugend. Nicht

Katharina Rahlf

338

Nachweis von Serumproteinen im Gewebe bei experimenteller Dysproteinämie  

Microsoft Academic Search

Zusammenfassung  Durch mehrwöchige Behandlung mit subcutanen Injektionen einer Casein-NaOH-Lösung wurde an Ratten eine Dysproteinämie erzeugt.\\u000a Mit Hilfe fluorescierender Antikörper wurde nach der vonCoons angegebenen Methode die Lokalisation verschiedener Serumproteine im Rattengewebe untersucht. Rattenalbumin sowie vor dem\\u000a Tode injiziertes Humanalbumin und?- Globulin konnten außerhalb der Gefäße in den Kupfferschen Sternzellen der Leber, im Muskelinterstitium und dem Interstitium\\u000a der Nieren nachgewiesen werden, während

P. Gerhardt Scheurlen; Josef Wollensak

1957-01-01

339

Hemmung von Epithelregeneration und cornealer Wundheilung beim Kaninchen durch Antimetaboliten  

Microsoft Academic Search

Die vorliegenden Untersuchungen bringen den statistisch gesicherten Hinweis, daß unter den gegebenen experimentellen Bedingungen Para-Fluor-Phenyl-Alanin eine geringe und 0,1 % ige IUDR-Tropfen eine ausgeprägte Hemmung auf die Epithelregeneration ausüben. Dies scheint bei Anwendung von 0.1 % iger IUDR-Salbe weniger der Fall zu sein. Im histologischen Präparat war gegenüber den Kontrollen kein sicherer Unterschied zu erkennen.

J. Wollensak; W. Kypke

1965-01-01

340

Dr. Wernher Von Braun at the launch of Apollo 11.  

NASA Technical Reports Server (NTRS)

Mission officials relax, all smiles, a few moments after the successful launch of the Apollo 11 spacecraft by Saturn V vehicle AS-506. Relieved of the tension of waiting through the countdown are (left to right) Charles W. Matthews, NASA deputy associate administrator for manned space flight; Dr. Wernher Von Braun, Director of the Marshall Space Flight Center; Dr. George E. Meuller, NASA associate administrator for manned spaceflight, and Lt. General Samuel C. Phillips, director of the Apollo program.

1999-01-01

341

Johann Baptist von Schweitzer: the queer Marx loved to hate.  

PubMed

Despite his conviction on a morals charge involving a boy, the early German Social Democrat Johann Baptist von Schweitzer went on to have a successful political career. His life furnishes the context to present remarks by his political opponents Marx and Engels, which reveal their deep-seated homophobia. It is pointed out that this has been glossed over by the translations of the recently published Marx/Engels Collected Works. Some remarks on boy-love and anarchism are appended. PMID:8666759

Kennedy, H

1995-01-01

342

Nutzergerechte Entwicklung der Mensch-Maschine-Interaktion von Fahrerassistenzsystemen  

NASA Astrophysics Data System (ADS)

Durch langjährige Forschungen bei Kfz-Herstellern, Zulieferfirmen und an Hochschulen sind umfangreiche, aber dennoch lückenhafte Erkenntnisse über das Zusammenspiel zwischen FAS und Nutzer gewonnen worden. In deutschen und internationalen Projekten wie z. B. PROMETHEUS, DRIVE, MOTIV, INVENT, RESPONSE und AKTIV haben sich Kfz-Hersteller, Zulieferfirmen, Hochschulen und weitere staatliche und private Forschungseinrichtungen zusammengefunden, um die vorwettbewerbliche Forschung für derartige Systeme voranzutreiben. Im folgenden Kapitel sollen einige der gewonnenen Kenntnisse dargelegt werden, um die Entwicklung des HMI von FAS zu erleichtern.

König, Winfried

343

von Willebrand factor in cadaveric urine for forensic investigation.  

PubMed

Preliminary experimental study of urinary von Willebrand factor (VWF) concentration was undertaken to evaluate the utility of this parameter in forensic investigations. ELISA was used to measure VWF concentration. Correlations of urinary VWF with cause of death and postmortem interval (PMI) were ascertained. As PMI advanced, urinary VWF increased but plasma VWF did not. Cause of death was not significantly correlated with VWF. This study indicated the possibility that urinalysis would be helpful to estimate PMI. PMID:19515598

Kasuda, Shogo; Kudo, Risa; Morimura, Yoshifumi; Tatsumi, Kohei; Sakurai, Yoshihiko; Shima, Midori; Hatake, Katsuhiko

2009-09-01

344

Massive postoperative intramuscular bleeding in acquired von Willebrand's disease  

Microsoft Academic Search

We describe a case of acquired von Willebrand's disease (vWD) associated with monoclonal gammopathy with undetermined significance (MGUS) in a 54-year-old man who was admitted with hemarthrosis and extensive thigh muscle hematoma following arthroscopic surgery and postoperative prophylaxis with low molecular weight heparin. Coagulation tests were compatible with acquired vWD: prolonged activated partial thromboplastin time (aPTT) (56.1 s), decreased levels

M. Krebs; B. Meyer; P. Quehenberger; P. Turecek; M. Hejna; W. Sperr; K. Lechner; I. Pabinger

2002-01-01

345

NEW FAMILIES WITH VON WILLEBRAND DISEASE TYPE 2M (VICENZA)  

Microsoft Academic Search

The variant von Willebrand disease (vWd) variant type 2M (Vicenza) was identified in 13 patients of 7 unrelated families. 11 patients were from different parts of Germany and 2 patients from Turkey. Hitherto this variant of vWd has been described only in two families originating from the province of Vicenza in Northern Italy. Characteristically this type of vWd shows the

Barbara Zieger; Ulrich Budde; Ursula Jessat; Rainer Zimmerman; Michael Simon; Ralph Kätzel; Anton H. Sutor

1997-01-01

346

Beobachtungen an einer blaublühenden Sippe von Lithospermum arvense L  

Microsoft Academic Search

Zusammenfassung Die morphologischen, ökologischen, phänologischen und geographischen Unterschiede der in Mittel-Europa auftretenden blaublühenden Sippe vonLithospermum arvense L. gegenüber der weißblühenden Normalform werden herausgearbeitet und ihre bis jetzt bekannten Fundorte zusammengestellt. Die Sippe (var.coerulescens DC.), die möglicherweise einen höheren Rang verdient, nimmt innerhalb des Formenkreises der Art eine ursprüngliche Stellung ein, während die weitverbreitete weißblühende Unkrautsippe abgeleitet erscheint. Der im einzelnen

Peter Hanelt; Jürgen Schultze-Motel

1962-01-01

347

Off-Label-Use oder von der Notwendigkeit der Arzneimittelzulassung  

Microsoft Academic Search

Der wohlbegründete Off-Label-Use von Arzneimitteln als Ausnahme ärztlichen Handelns ist teilweise notwendig, ja kann sogar\\u000a zwingend erforderlich sein, wenn es bei einer schweren Krankheit keine Behandlungsalternativen gibt und nach dem Stand der\\u000a wissenschaftlichen Erkenntnis die begründete Aussicht besteht, dass mit dem Medikament ein Behandlungserfolg erzielt werden\\u000a kann.Aus Gründen der Arzneimittelsicherheit und des aktiven Verbraucherschutzes darf einem paternalistischen Ansatz der Medizin,

H. Schweim; C. Behles

2003-01-01

348

Von Mises' potential flow wave equation and nonlinear analog gravity  

NASA Astrophysics Data System (ADS)

Von Mises’ nonlinear second-order wave equation for the velocity potential in the case of an irrotational, compressible and barotropic classical perfect fluid is connected to the analog gravity formalism. It is shown that while the standard acoustic metric, built on a certain background, remains central in the higher-order perturbative scheme, at full nonlinear level it plays a less relevant role. Possible applications both for simulations and experiments are discussed.

Cherubini, C.; Filippi, S.

2011-12-01

349

FROM THE HISTORY OF PHYSICS: John von Neumann  

NASA Astrophysics Data System (ADS)

This article is dedicated to John von Neumann, one of the most outstanding scholars of the 20th century. His life was short but bright, and his contribution to almost all branches of mathematics, as well as to physics, economics, biology, and astronomy was enormous. He constructed some of the first computers and he was among the key persons in the American atomic project. Development of his ideas will continue to play a vital part in various areas of pure and applied mathematics.

Monastyrskii, Mikhail I.

2004-12-01

350

A new perspective on the cramér-von mises test  

Microsoft Academic Search

The Cramér-von Mises test statistic for the general k sample problem can be rewritten in terms of Gini's mean difference with repetition, and this in turn leads to a derivation as a score test from a self-exciting point-process model. It also leads to a computationally useful form of the test statistic as a correlation between a function of an observation's

Rose D. Baker

1997-01-01

351

High-resolution von Hamos crystal X-ray spectrometer  

NASA Astrophysics Data System (ADS)

A high-resolution von Hamos Bragg crystal X-ray spectrometer is described. The instrument was designed for the study of X-ray emission from low- Z elements and L X-ray spectra of medium to high Z targets induced by photon and particle impact. The construction details and operational characteristics of the spectrometer are presented along with the data illustrating the utility of this facility in different areas of research in atomic physics.

Hoszowska, J.; Dousse, J.-Cl.; Kern, J.; Rhême, Ch.

1996-02-01

352

High-resolution von Hamos crystal X-ray spectrometer  

Microsoft Academic Search

A high-resolution von Hamos Bragg crystal X-ray spectrometer is described. The instrument was designed for the study of X-ray emission from low-Z elements and L X-ray spectra of medium to high Z targets induced by photon and particle impact. The construction details and operational characteristics of the spectrometer are presented along with the data illustrating the utility of this facility

J. Hoszowska; J.-Cl. Dousse; J. Kern; Ch. Rhême

1996-01-01

353

Interpolatability distinguishes LOCC from separable von Neumann measurements  

NASA Astrophysics Data System (ADS)

Local operations with classical communication (LOCC) and separable operations are two classes of quantum operations that play key roles in the study of quantum entanglement. Separable operations are strictly more powerful than LOCC, but no simple explanation of this phenomenon is known. We show that, in the case of von Neumann measurements, the ability to interpolate measurements is an operational principle that sets apart LOCC and separable operations.

Childs, Andrew M.; Leung, Debbie; Man?inska, Laura; Ozols, Maris

2013-11-01

354

Von Gierke's Disease Adopts an Orphan (and Its Partner)  

NSDL National Science Digital Library

The enzyme glucose-6-phosphatase is critical for maintaining fasting blood sugar levels by increasing hepatic glucose production. Its absence in patients with von Gierke’s disease leads to severe hypoglycemia and abnormal accumulation of glycogen (glycogenosis) in the liver. New players that control the expression of glucose-6-phosphatase have been identified that may provide insight into this metabolic disorder, as well as type 2 diabetes.

Alan Cheng (Ann Arbor;University of Michigan Medical Center REV); Alan R. Saltiel (Ann Arbor;University of Michigan Medical Center REV)

2009-02-17

355

Von Recklinghausen's disease--elements of clinical practice.  

PubMed

Neurofibromatosis is a condition described for the first time by Von Recklingahausen in 1882. This disease is one of the most common genetic disorders and is characterized by multiple tumors of the central and peripheral nervous system, brown macules on the skin, bone deformities, and by vascular and visceral disorders. Despite extensive basic science research, the diagnosis is still based largely on clinical criteria, which often present gradually during childhood. PMID:18386614

Burnei, G; Vlad, C; Georgescu, Ileana; Gavriliu, S; Dan, Daniela; Vlad, Ana Maria

2006-01-01

356

Konzept zur Basisausbildung von Notärzten im Sanitätsdienst der Bundeswehr  

Microsoft Academic Search

Zusammenfassung  Mit der deutlich gestiegenen Bedrohungs- und Gefährdungslage in den Auslandseinsätzen der Bundeswehr werden an die notfallmedizinische\\u000a Versorgung verwundeter Soldaten ganz neue Anforderungen gestellt. Diesen veränderten Einsatzerfordernissen muss auch bei der\\u000a notfallmedizinischen Qualifizierung der Sanitätsoffiziere Rechnung getragen werden. Mit der „Weisung für die Notfallmedizinische\\u000a Weiterbildung von Sanitätsoffizieren Arzt“ des Inspekteurs des Sanitätsdienstes der Bundeswehr wurden die Grundlagen geschaffen,\\u000a eine dem zivilen

M. Helm; J. Lührs; F. Josse; G. Kremers; N. Weller; L. Lampl

357

[Acute myeloblastosis in von Jaksch-Luzet syndrome].  

PubMed

A 7 month-old infant of Italian origin, who was given a vitamin-D deficient diet developed a Von Jaksch-Luzet syndrome with more than 20% myeloblasts in the bone marrow. Plasma levels of vitamin D metabolites wer low and parathormone levels were high. A low dose of vitamin D3 (2,000 IU cholecalciferol/day) resulted in the recovery of a normal phosphocalcic balance and in the disappearance of myeloblastosis. PMID:6312916

Kassam, S; Vainsel, M; Otten, J; Fondu, P

1983-01-01

358

The Radon-Nikodym theorem for von neumann algebras  

Microsoft Academic Search

Let ? be a faithful normal semi-finite weight on a von Neumann algebraM. For each normal semi-finite weight ? onM, invariant under the modular automorphism group ? of ?, there is a unique self-adjoint positive operatorh, affiliated with the sub-algebra of fixed-points for ?, such that ?=?(h·). Conversely, each suchh determines a ?-invariant normal semi-finite weight. An easy application of

Gert K. Pedersen; Masamichi Takesaki

1973-01-01

359

THE FREE ENTROPY DIMENSION OF HYPERFINITE VON NEUMANN ALGEB RAS  

Microsoft Academic Search

Suppose M is a hyperfinite von Neumann algebra with a normal, tracial st ate ' and {a1,...,an} is a set of selfadjoint generators for M. We calculate ?0(a1,...,an), the modified free entropy dimension of {a1,...,an}. Moreover we show that ?0(a1,...,an) depends only on M and '. Consequently ?0(a1,...,an) is independent of the choice of generators for M. In the course

KENLEY JUNG

2003-01-01

360

KK-theory and Spectral Flow in von Neumann Algebras  

Microsoft Academic Search

We present a definition of spectral flow relative to any norm closed ideal J in any von Neumann algebra N. Given a path D(t) of selfadjoint operators in N which are invertible in N\\/J, the spectral flow produces a class in K_0(J). In the case when N is semifinite, the numerical spectral flow of the path coincides with the value

Jens Kaad; Ryszard Nest; Adam Rennie

2007-01-01

361

ON THE VON NEUMANN-JORDAN CONSTANT FOR BANACH SPACES  

Microsoft Academic Search

Let CNJ(E) be the von Neumann-Jordan constant for a Banach space E. It is known that 1 CNJ(E) 2 for any Banach space E ;a nd Eis a Hilbert space if and only if CNJ(E) = 1. We show that: (i) If E is uniformly convex, CNJ(E) is less than two; and conversely the condition CNJ(E) < 2 implies that

MIKIO KATO; YASUJI TAKAHASHI

362

Quantitative sensory testing.  

PubMed

Quantitative sensory testing is a reliable way of assessing large and small sensory nerve fiber function. Sensory deficits may be quantified and the data used in parametric statistical analysis in research studies and drug trials. It is an important addition to the neurophysiologic armamentarium, because conventional sensory nerve conduction tests only the large fibers. QST is a psychophysical test and lacks the objectivity of NCS. The results are subject to changes owing to distraction, boredom, mental fatigue, drowsiness, or confusion. When patients are consciously or unconsciously biased toward an abnormal QST result, no psychophysical testing can reliably distinguish these patients from those with organic disease. QST tests the integrity of the entire sensory neuraxis and is of no localizing value. Dysfunction of the peripheral nerves or central nervous system may give rise to abnormalities in QST. As is true for other neurophysiologic tests, QST results should always be interpreted in light of the patient's clinical presentation. Quantitative sensory testing has been shown to be reasonably reproducible over a period of days or weeks in normal subjects. Because longitudinal QST studies of patients in drug trials are usually performed over a period of several months to a few years, reproducibility studies on the placebo-control group should be included. For individual patients, more studies are needed to determine the maximum allowable difference between two QSTs that can be attributed to experimental error. The reproducibility of thermal thresholds may not be as good as that of vibration threshold. Different commercially available QST instruments have different specifications (thermode size, stimulus characteristics), testing protocols, algorithms, and normal values. Only QST instruments and their corresponding methodologies that have been shown to be reproducible should be used for research and patient care. The data in the literature do not allow conclusions regarding the superiority of any QST instruments. The future of QST is promising; however, many factors can affect QST results. As is true for other neurophysiologic tests, QST is susceptible to many extraneous factors and to misuse when not properly interpreted by the clinician. PMID:12795516

Siao, Peter; Cros, Didier P

2003-05-01

363

The British Interplanetary Society - Val Cleaver and Wernher von Braun  

NASA Astrophysics Data System (ADS)

This article is concerned with the early relationship between Wernher von Braun and the British Interplanetary Society (BIS). The BIS/Wernher von Braun/Val Cleaver correspondence files located here at the US Space & Rocket Center in Huntsville, Alabama are unparalleled. As one reads the stimulating comments between Cleaver and von Braun, the need to share their thoughts prevails. Following is an excerpt from one letter that whets ones appetite for more. 10 June 1951 Cleaver writes, “I'm so glad you enjoyed my last letter, and look forward to your promised further contribution to our discussion of the ethics of science in general and astronautics in particu- lar. As regards the one particular point on which you found yourself unable to hold your fire, I should say there are really two distinct issues at stake:. . .” This article attempts to represent the best of the letters as they goad each other on scientific principles, means to prevent wars, and other philosophic ideas.

Willhite, I. P.

364

Einflüsse von Fahrerassistenzsystemen auf die Systemarchitektur im Kraftfahrzeug  

NASA Astrophysics Data System (ADS)

Die Komplexität der Systeme bei modernen, hoch ausgestatteten Fahrzeugen hat ein hohes Niveau erreicht. Auch in Zukunft werden Innovationen im Kraftfahrzeug vermehrt nur über hochvernetzte und komplexe Systeme zu realisieren sein. Dies gilt in besonderem Maße für das Gebiet der Fahrerassistenz. Aufgrund der Nutzung von sensorisch erfasster Information über die Fahrumgebung, fahrzeuglokaler Daten und der Nutzung der bereits im Fahrzeug verbauten Aktorik sind Fahrerassistenzsysteme geradezu ein Synonym für verteilte hochvernetzte Funktionen. Umfang und Qualität der sensorisch erfassbaren Information und ihre Interpretation bestimmen den Funktionsumfang und die Komplexität der jeweiligen Assistenzfunktion wesentlich. Die technische Sensorik, z. B. Radar oder Kamerasysteme, nutzt gleiche oder ähnliche Information wie der Fahrer. Es wird allerdings auch auf längere Sicht keine Sensorik geben, die die Gesamtheit der Wahrnehmungsleistungen des Menschen und seine Fähigkeit der Interpretation dieser Daten in unterschiedlichen Kontexten erreicht. In einzelnen Aspekten sind technische Sensoren aber durchaus der menschlichen Wahrnehmung überlegen, wie beispielsweise bezüglich Daueraufmerksamkeit, Geschwindigkeitsbestimmung bewegter Objekte oder aufgrund von Empfindlichkeit in anderen Wellenlängenbereichen als der des menschlichen Auges. Insbesondere die Verknüpfung der Sensorinformationen, die so genannte Sensorfusion, bietet ein hohes Potenzial, den Fahrer zu entlasten und die Fahrsicherheit zu erhöhen bzw. kritischen Fahrsituationen vorzubeugen. Durch die Sensorfusion wird die Qualität der Interpretation von mit technischer Sensorik erfassten Daten deutlich erhöht. Hierzu sind Entscheidungen über die Fusionsebene wie Rohdaten, aufbereitete oder interpretierte Daten zu treffen sowie geeignete Fusionsarchitekturen im Fahrzeug vorzusehen (siehe Kapitel 17).

Reichart, Günter; Bielefeld, Jürgen

365

Einfache Grauwert-Transferfunktion für die Berechnung von digital rekonstruierten Röntgenbildern  

NASA Astrophysics Data System (ADS)

Das Raycasting ist ein etabliertes Verfahren zur Berechnung von Digital Rekonstruierten Röntgenbildern (DRRs), also auf Basis von CT-Daten approximierten Radiographien, welche die Projektion eines Summationsbilds des 3D-CT-Volumens auf eine zweidimensionale Bildebene darstellen. Die Wirkung eines von einem Raycasting-Strahl durchquerten Voxels auf das Ergebnispixel im DRR kann unter anderem mit Hilfe von Transferfunktionen berechnet werden, die den Grauwert des Voxels in einen Schwächungskoeffizienten für den Strahl umrechnen. Es wird ein einfaches mathematisches Modell für eine solche Transferfunktion vorgestellt, dessen Parametrisierung eng an die klinische Praxis angelehnt ist.

Newe, Axel; Rascher-Friesenhausen, Richard; Peitgen, Heinz-Otto

366

Quantitative Environmental Learning Project  

NSDL National Science Digital Library

QELP is a NSF-sponsored program headed up by researchers Greg Langkamp and Joe Hull at Seattle Central Community College and designed "to promote curricular revision by linking mathematics and environmental science." These QELP educators have been developing effective classroom-ready resources (e.g., lab exercises) which draw heavily on real world data, use introductory college-level mathematics (algebra, difference equations and statistics), and promote student investigation and collaboration. Although the project is still in its development phase (it will eventually lead to a published lab manual of exercises), this Website offers several excellent examples of quantitative environmental exercises. The Biota and Linear Regression exercise links linear regression and graphical analysis with biota and biometrics; the Hazardous Waste and Statistical Analysis exercise links statistical analysis of normal distributions with solid and hazardous waste. Each exercise includes Notes to the Instructor, Student Background Information, and a fully elaborated set of instructions. In addition, the site includes the exercises's related data sets (with some graphics). Undergraduates or first-year graduate students will be likely to benefit from these well-conceived exercises.

367

Die Wirkung von Änderungen der Natriumkonzentration im Suspensionsmedium und von Strophanthin auf die Sauerstoffaufnahme isolierter Nierenzellen der Ratte  

Microsoft Academic Search

Zusammenfassung  \\u000a \\u000a \\u000a \\u000a 1. \\u000a \\u000a Zellen aus Rinde und äußerer Markzone der Rattenniere wurden mit Hilfe des Enzyms Kollagenase isoliert.\\u000a \\u000a \\u000a \\u000a \\u000a 2. \\u000a \\u000a Die Wirkung von Strophanthinzusatz zum Suspensionsmedium und der Effekt der Inkubation in Na-freier Lösung auf den Sauerstoffverbrauch\\u000a der isolierten Zellen wurde im Warburg-Apparat untersucht.\\u000a \\u000a \\u000a \\u000a \\u000a 3. \\u000a \\u000a Der Sauerstoffverbrauch isolierter Nierenrindenzellen in einer isotonischen Nährlösung mit einer Na-Konzentration von 140\\u000a mM\\/l betrug bei 37°C

Gisela Grube; Karin Philipps; Christoph Weiss

1967-01-01

368

Defective dimerization of von Willebrand factor subunits due to a Cys-> Arg mutation in type IID von Willebrand disease.  

PubMed Central

The same heterozygous T -> C transition at nt 8567 of the von Willebrand factor (vWF) transcript was found in two unrelated patients with type III) von Willebrand disease, with no other apparent abnormality. In one family, both alleles were normal in the parents and one sister; thus, the mutation originated de novo in the proposita. The second patient also had asymptomatic parents who, however, were not available for study. The structural consequences of the identified mutation, resulting in the CyS2010 -> Arg substitution, were evaluated by expression of the vWF carboxyl-terminal domain containing residues 1366-2050. Insect cells infected with recombinant baculovirus expressing normal vWF sequence secreted a disulfide linked dimeric molecule with an apparent molecular mass of 150 kDa before reduction, yielding a single band of 80 kDa after disulfide bond reduction. In contrast, cells expressing the mutant fragment secreted a monomeric molecule of apparent molecular mass of 80 kDa, which remained unchanged after reduction. We conclude that CyS2010 is essential for normal dimerization of vWF subunits through disulfide bonding of carboxyl-terminal domains and that a heterozygous mutation in the corresponding codon is responsible for defective multimer formation in type III) von Willebrand disease. Images Fig. 1 Fig. 2 Fig. 4

Schneppenheim, R; Brassard, J; Krey, S; Budde, U; Kunicki, T J; Holmberg, L; Ware, J; Ruggeri, Z M

1996-01-01

369

The anti-von Willebrand factor aptamer ARC1779 increases von Willebrand factor levels and platelet counts in patients with type 2B von Willebrand disease.  

PubMed

Blockade of hyperactive von Willebrand factor (VWF) by ARC1779 blunted the platelet drop induced by desmopressin in patients with type 2B von Willebrand disease (VWD). Thus, we hypothesised that ARC1779 may increase VWF levels and correct thrombocytopenia. Three thrombocytopenic patients suffering from type 2B VWD received a loading dose of 0.23 mg/kg ARC1779 followed by 4 ?g/kg/min intravenously for 72 hours in a prospective clinical trial. ARC1779 was well tolerated and safe. Plasma concentrations of ARC1779 increased to 76 ?g/ml (59-130) leading to an immediate decrease of free VWF A1 domains. VWF/FVIII levels increased as early as 12 h after start of infusion, peaked near the end of infusion, and returned to baseline at follow-up. VWF ristocetin cofactor activity (VWF:RCo) showed a median 10-fold increase 8 hours after end of infusion, while the median VWF-antigen and FVIII increase was less (5-fold and 4-fold, respectively). Most importantly inhibition of hyperactive VWF rapidly increased platelet counts from 40 x 10(9)/l (38-58 x 10(9)//l) to a maximum of 146 x 10(9)//l (107-248 x 10(9)//l). In conclusion, ARC1779 markedly increases VWF/FVIII levels and most importantly improves or even corrects thrombocytopenia in VWD type 2B patients. This underscores the in vivo potency of ARC1779. PMID:22740102

Jilma-Stohlawetz, Petra; Knöbl, Paul; Gilbert, James C; Jilma, Bernd

2012-08-01

370

QUANTITATIVE 15N NMR SPECTROSCOPY  

EPA Science Inventory

Line intensities in 15N NMR spectra are strongly influenced by spin-lattice and spin-spin relaxation times, relaxation mechanisms and experimental conditions. Special care has to be taken in using 15N spectra for quantitative purposes. Quantitative aspects are discussed for the 1...

371

Quantitative spectroscopy of Deneb  

NASA Astrophysics Data System (ADS)

Context: Quantitative spectroscopy of luminous BA-type supergiants offers a high potential for modern astrophysics. Detailed studies allow the evolution of massive stars, galactochemical evolution, and the cosmic distance scale to be constrained observationally. Aims: A detailed and comprehensive understanding of the atmospheres of BA-type supergiants is required in order to use this potential properly. The degree to which we can rely on quantitative studies of this class of stars as a whole depends on the quality of the analyses for benchmark objects. We constrain the basic atmospheric parameters and fundamental stellar parameters, as well as chemical abundances of the prototype A-type supergiant Deneb to unprecedented accuracy by applying a sophisticated analysis methodology, which has recently been developed and tested. Methods: The analysis is based on high-S/N and high-resolution spectra in the visual and near-IR. Stellar parameters and abundances for numerous astrophysically interesting elements are derived from synthesis of the photospheric spectrum using a hybrid non-LTE technique, i.e. line-blanketed LTE model atmospheres and non-LTE line formation. Multiple metal ionisation equilibria and numerous hydrogen lines from the Balmer, Paschen, Brackett, and Pfund series are utilised simultaneously for the stellar parameter determination. The stellar wind properties are derived from H? line-profile fitting using line-blanketed hydrodynamic non-LTE models. Further constraints come from matching the photospheric spectral energy distribution from the UV to the near-IR L band. Results: The atmospheric parameters of Deneb are tightly constrained: effective temperature T_eff = 8525±75 K, surface gravity log g = 1.10±0.05, microturbulence ? = 8±1 km s-1, macroturbulence, and projected rotational velocity v sin i are both 20 ± 2 km s-1. The abundance analysis gives helium enrichment by 0.10 dex relative to solar and an N/C ratio of 4.44 ± 0.84 (mass fraction), implying strong mixing with CN-processed matter. The heavier elements are consistently underabundant by 0.20 dex compared to solar. Peculiar abundance patterns, which were suggested in previous analyses cannot be confirmed. Accounting for non-LTE effects is essential for removing systematic trends in the abundance determination, for minimising statistical 1?-uncertainties to ?10-20% and for establishing all ionisation equilibria at the same time. Conclusions: A luminosity of (1.96 ± 0.32)×105 L?, a radius of 203 ± 17 R_?, and a current mass of 19 ± 4 M? are derived. Comparison with stellar evolution predictions suggests that Deneb started as a fast-rotating late O-type star with M^ZAMS? 23 M_? on the main sequence and is currently evolving to the red supergiant stage. Based on observations collected at the Centro Astronómico Hispano Alemán (CAHA) at Calar Alto, operated jointly by the Max-Planck Institut für Astronomie and the Instituto de Astrofisica de Andalucia (CSIC). Appendix A is only available in electronic form at http://www.aanda.org

Schiller, F.; Przybilla, N.

2008-03-01

372

Quantitative luminescence imaging system  

NASA Astrophysics Data System (ADS)

The goal of the Measurement of Chemiluminescence project is to develop and deliver a suite of imaging radiometric instruments for measuring spatial distributions of chemiluminescence. Envisioned deliverables include instruments working at the microscopic, macroscopic, and life-sized scales. Both laboratory and field portable instruments are envisioned. The project also includes development of phantoms as enclosures for the diazoluminomelanin (DALM) chemiluminescent chemistry. A suite of either phantoms in a variety of typical poses, or phantoms that could be adjusted to a variety of poses, is envisioned. These are to include small mammals (rats), mid-sized mammals (monkeys), and human body parts. A complete human phantom that can be posed is a long-term goal of the development. Taken together, the chemistry and instrumentation provide a means for imaging rf dosimetry based on chemiluminescence induced by the heat resulting from rf energy absorption. The first delivered instrument, the Quantitative Luminescence Imaging System (QLIS), resulted in a patent, and an R&D Magazine 1991 R&D 100 award, recognizing it as one of the 100 most significant technological developments of 1991. The current status of the project is that three systems have been delivered, several related studies have been conducted, two preliminary human hand phantoms have been delivered, system upgrades have been implemented, and calibrations have been maintained. Current development includes sensitivity improvements to the microscope-based system; extension of the large-scale (potentially life-sized targets) system to field portable applications; extension of the 2-D large-scale system to 3-D measurement; imminent delivery of a more refined human hand phantom and a rat phantom; rf, thermal and imaging subsystem integration; and continued calibration and upgrade support.

Batishko, C. R.; Stahl, K. A.; Fecht, B. A.

373

Quantitative Luminescence Imaging System  

SciTech Connect

The goal of the MEASUREMENT OF CHEMILUMINESCENCE project is to develop and deliver a suite of imaging radiometric instruments for measuring spatial distributions of chemiluminescence. Envisioned deliverables include instruments working at the microscopic, macroscopic, and life-sized scales. Both laboratory and field portable instruments are envisioned. The project also includes development of phantoms as enclosures for the diazoluminomelanin (DALM) chemiluminescent chemistry. A suite of either phantoms in a variety of typical poses, or phantoms that could be adjusted to a variety of poses, is envisioned. These are to include small mammals (rats), mid-sized mammals (monkeys), and human body parts. A complete human phantom that can be posed is a long-term goal of the development. Taken together, the chemistry and instrumentation provide a means for imaging rf dosimetry based on chemiluminescence induced by the heat resulting from rf energy absorption. The first delivered instrument, the Quantitative Luminescence Imaging System (QLIS), resulted in a patent, and an R&D Magazine 1991 R&D 100 award, recognizing it as one of the 100 most significant technological developments of 1991. The current status of the project is that three systems have been delivered, several related studies have been conducted, two preliminary human hand phantoms have been delivered, system upgrades have been implemented, and calibrations have been maintained. Current development includes sensitivity improvements to the microscope-based system; extension of the large-scale (potentially life-sized targets) system to field portable applications; extension of the 2-D large-scale system to 3-D measurement; imminent delivery of a more refined human hand phantom and a rat phantom; rf, thermal and imaging subsystem integration; and continued calibration and upgrade support.

Batishko, C.R.; Stahl, K.A.; Fecht, B.A.

1992-12-31

374

Polyamidmethode zur quantitativen Bestimmung der Nicotinsäure  

Microsoft Academic Search

A new method is described for the isolation of nicotinic acid (niacin) from pharmaceutical products. Niacin is separated by adsorption on activated polyamide-powder in a microchromatographic column. For libration of the vitamin the adsorbent is eluted with a solution of NaCl. The amide of nicotinic acid which is not adsorbed, passes through the column. With this method it is possible

Günter Lehmann; Hans-Gert Hahn

1968-01-01

375

Botschaften aus einer fernen Welt. Landung von Huygens auf Titan ein voller Erfolg  

NASA Astrophysics Data System (ADS)

Am 14. Januar 2005 trat die europäische Raumsonde Huygens in die dichte Gashülle des größten Saturnmonds Titan ein und sendete von dort zahlreiche Messdaten und Bilder zur Erde. Wie sich die kurze Mission von Huygens auf der Erde im Kontrollzentrum ESOC in Darmstadt darstellte, davon handelt dieser Bericht.

Althaus, Tilmann

2005-03-01

376

The Fate of Western Civilization: G. H. von Wright's Reflections on Science, Technology, and Global Society  

ERIC Educational Resources Information Center

This article introduces the central ideas of G. H. von Wright's cultural philosophy concerning the techno-scientific form of life. Georg Henrik von Wright (1916-2003) was best known for his achievements in the field of modal logic and for his association with Ludwig Wittgenstein. However, his work also included a critical analysis of science and…

Heikkero, Topi

2004-01-01

377

76 FR 36166 - Culturally Significant Objects Imported for Exhibition; Determinations: “Gabriel von Max: Be...  

Federal Register 2010, 2011, 2012, 2013

...Gabriel von Max: Be-Tailed Cousins and Phantasms of the Soul'' SUMMARY: Notice is hereby given of the following determinations...Gabriel von Max: Be-Tailed Cousins and Phantasms of the Soul,'' imported from abroad for temporary exhibition within...

2011-06-21

378

Einfluß von Secretin und Pankreozymin auf die Calciumsekretion im menschlichen Duodenalsaft bei normaler und gestörter Pankreasfunktion  

Microsoft Academic Search

Zusammenfassung 1. Konzentration und Mengenausscheidung von Calcium wurden im menschlichen Duodenalsaft basal, 60 min nach Secretin (1 E\\/kg) und 30 min nach Pankreozymin (1 E\\/kg) gemessen. Es wurden 38 Personen mit normaler Pankreasfunktion, 19 Patienten mit mäßiger und 18 mit ausgeprägter Pankreasinsuffizienz ohne Calcifizierung sowie sieben Kranke mit chronisch calcifizierender Pankreatitis untersucht. Zum Vergleich wurde die Konzentration von Kalium und

H. Goebell; Ch. Bode; H. D. Horn

1970-01-01

379

An Alternative Perspective on von Winterfeldt et al.'s (1997) Test of Consequence Monotonicity  

ERIC Educational Resources Information Center

D. von Winterfeldt, N.-K. Chung, R. D. Luce, and Y. Cho (see record 1997-03378-008) provided several tests for consequence monotonicity of choice or judgment, using certainty equivalents of gambles. The authors reaxiomatized consequence monotonicity in a probabilistic framework and reanalyzed von Winterfeldt et al.'s main experiment via a…

Ho, Moon-Ho R.; Regenwetter, Michel; Niederee, Reinhard; Heyer, Dieter

2005-01-01

380

Acquired von Willebrand syndromes: clinical features, aetiology, pathophysiology, classification and management  

Microsoft Academic Search

Acquired von Willebrand syndrome (AVWS) associated with hypothyroidism is of type 1, results from a decreased synthesis of factor VIII and von Willebrand factor (VWF), responds to desmopressin with normal half-life times for factor VIII and VWF parameters, and disappears after treatment with l-thyroxine. AVWS type I or III, which occurs in a minority of patients with Wilms' tumour in

Jan Jacques Michiels; Ulrich Budde; Marc van der Planken; Huub H. D. M. van Vliet; Wilfried Schroyens; Zwi Berneman

2001-01-01

381

Additional factor XII (hageman factor) deficiency in hemophilia a and in von willebrand syndrome  

Microsoft Academic Search

Summary Factor XII plasma levels were investigated with several methods in patients with hemophilia A and B and von Willebrand syndrome. There seem to be some families with hemophilia A or von Willebrand syndrome, who have an additional, congenital, partial lack of factor XII (Hageman factor). The mode of inheritance is independent of the other coagulation disorder. Frequently, the first

M. Barthels; J. Edel; B. Liese; H. E. Karges

1982-01-01

382

Acquired Von Willebrand syndrome is an early-onset problem in ventricular assist device patients  

Microsoft Academic Search

Objective: Acquired Von Willebrand syndrome (AVWS) can contribute to bleeding complications in patients with ventricular assist devices (VADs). AVWS results from shear stress, which causes unfolding of the high-molecular-weight (HMW) multimers of Von Willebrand factor (VWF) with subsequent cleavage. Loss of the HMW multimers of VWF is the leading finding in AVWS. In consequence, binding of VWF to collagen and

Claudia Heilmann; Ulrich Geisen; Friedhelm Beyersdorf; Lea Nakamura; Georg Trummer; Michael Berchtold-Herz; Christian Schlensak; Barbara Zieger

383

Expression of von Willebrand factor Normandy: An autosomal mutation that mimics hemophilia A  

Microsoft Academic Search

von Willebrand disease Normandy (vWD Normandy) is a recently described phenotype in which a mutant von Willebrand factor (VWF) appears structurally and functionally normal except that is does not bind to blood coagulation factor VIII. This interaction is required for normal survival of factor VIII in the circulation; consequently, vWD Normandy can present as apparent hemophilia A but with autosomal

E. A. Tuley; N. K. Worrall; J. E. Sadler; C. Gaucher; S. Jorieux; C. Mazurier

1991-01-01

384

X-ray analysis with a highly oriented pyrolytic graphite-based von Hamos spectrometer  

Microsoft Academic Search

The feasibility of the realization of a HOPG-based von Hamos spectrometer with a high energy resolution is discussed on the basis of the acquired theoretical and experimental data. The spectrometer makes use of HOPG films, which can be deposited on a mould of any shape, including the cylindrical form. In this way focusing geometry of a von Hamos scheme can

V. A. Arkadiev; A. A. Bjeoumikhov; M. Haschke; N. Langhoff; H. Legall; H. Stiel; R. Wedell

2007-01-01

385

Elektronenmikroskopische Untersuchungen zur Cytologie und Angiologie des Epiphysenstiels von Anolis carolinensis  

Microsoft Academic Search

Es werden pigmentartige Granula in den Ependymzellen des Epiphysenstiels von Anolis carolinensis beschrieben. Die Propigmentgranula mit einem Durchmesser von 100 Å werden im Golgiapparat und Ergastoplasma gebildet und in Vakuolen oder Zytosomen kondensiert. Strukturell gleichartige Mikrogranula kommen in multitubulären Körpern vor, die mit dem Golgiapparat verbunden sind.

W. Lierse

1965-01-01

386

Beobachtungen an der Glia des subfornikalen Organes von Galago crassicaudatus Geoffroy 1812 (Prosimiae, Lorisiformes)  

Microsoft Academic Search

Die Untersuchung befaßt sich mit dem Ependym und der Makroglia des subfornikalen Organes von Galago crassicaudatus. Aus Rücksicht auf die anderweitige Verwendung des sehr seltenen Materiales konnte die Gold-Sublimat-methode von Cajal nicht angewendet werden. Die Faserglia erscheint in 2 Typen, den Astrocyten und Tanycyten (Horstmann). Beide bilden auch Gefäßfortsätze, die sich in typischer Weise der Wand der Gefäße anlegen. Eine

H. Hofer

1957-01-01

387

Tracial gauge norms on finite von Neumann algebras satisfying the weak Dixmier property  

Microsoft Academic Search

In this paper we set up a representation theorem for tracial gauge norms on finite von Neumann algebras satisfying the weak Dixmier property in terms of Ky Fan norms. Examples of tracial gauge norms on finite von Neumann algebras satisfying the weak Dixmier property include unitarily invariant norms on finite factors (type II1 factors and Mn(C)) and symmetric gauge norms

Junsheng Fang; Don Hadwin; Eric Nordgren; Junhao Shen

2008-01-01

388

The Effros-Marechal topology in the space of von Neumann algebras  

Microsoft Academic Search

New concepts of limes inferior and limes superior in the space of von Neumann algebras on a fixed Hilbert space are defined, and the topology corresponding to these notions is related to earlier works of Effros and Marechal. A main technical result is that the commutant operation is a homeomorphism on the space of von Neumann algebras with this topology.

Carl Winslow; Uffe Haagerup

1998-01-01

389

Determination of von Willebrand Factor Activity: Evaluation of the HaemosIL™ Assay in Comparison With Established Procedures  

Microsoft Academic Search

Determination of von Willebrand factor activity is required for diagnosis and classification of von Willebrand disease. In addition, von Willebrand factor activity can be of prognostic relevance in several clinical entities including thromboembolic and cardiovascular disorders in which elevated activity correlates with a poor prognosis. The HaemosIL™ assay (Instrumentation Laboratory GmbH, Munich, Germany) provides a new fully automated procedure for

Christoph Sucker; Beate Senft; Rüdiger E. Scharf; Rainer B. Zotz

2006-01-01

390

Human plasma von Willebrand factor/factor VIII complex (Haemate P/Humate-P): in von Willebrand disease and haemophilia A.  

PubMed

Haemate P/Humate-P is a pasteurised human plasma-derived concentrate containing coagulation factor VIII and a near-normal spectrum of von Willebrand factor multimers, including high-molecular weight multimers, for intravenous use in patients with von Willebrand disease or haemophilia A. Extensive clinical experience over the past 25 years has shown that Haemate P/Humate-P provides effective haemostatic control for the prevention and treatment of bleeds in patients with these conditions, with no confirmed cases of viral or prion transmission occurring during this time. In small prospective and retrospective noncomparative studies, Haemate P/Humate-P provided effective haemostatic control for the prevention and treatment of bleeding episodes in the vast majority of paediatric and adult patients with von Willebrand disease. Haemate P/Humate-P was generally well tolerated in patients with von Willebrand disease or haemophilia A. PMID:17600395

Carter, Natalie J; Scott, Lesley J

2007-01-01

391

Experimentelle Bestimmung der stellaren (n,(gamma))-Querschnitte von (sup 148)Sm und (sup 150)Sm und die Konsequenzen fuer den s-Prozess. (Experimental determination of the stellar neutron capture cross sections of (sup 148)Sm and (sup 150)Sm and the consequences for the s-process).  

National Technical Information Service (NTIS)

The Karlsruhe 4(pi)-BaF(sub 2)-detector was upgraded by implementation of an ADC system, consisting of two ADC's for each of the 42 detector modules for determination of the gamma-ray energy and time of flight. A preprocessing option allows for an examina...

K. H. Guber

1993-01-01

393

von Baer's law for the ages: lost and found principles of developmental evolution.  

PubMed

In 1828, Karl Ernst von Baer formulated a series of empirically defined rules, which became widely known as the 'Law of Development' or 'von Baer's law of embryology'. This was one the most significant attempts to define the principles that connected morphological complexity and embryonic development. Understanding this relation is central to both evolutionary biology and developmental genetics. Von Baer's ideas have been both a source of inspiration to generations of biologists and a target of continuous criticism over many years. With advances in multiple fields, including paleontology, cladistics, phylogenetics, genomics, and cell and developmental biology, it is now possible to examine carefully the significance of von Baer's law and its predictions. In this review, I argue that, 185 years after von Baer's law was first formulated, its main concepts after proper refurbishing remain surprisingly relevant in revealing the fundamentals of the evolution-development connection, and suggest that their explanation should become the focus of renewed research. PMID:24120296

Abzhanov, Arhat

2013-12-01

394

Managing Patients with von Willebrand Disease Type 1, 2 and 3 with Desmopressin and von Willebrand Factor-Factor VIII Concentrate in Surgical Settings  

Microsoft Academic Search

Guidelines and recommendations for the acute and prophylactic treatment of bleeding in von Willebrand disease (VWD) patients with von Willebrand factor (VWF)\\/factor VIII (FVIII) concentrates should be based on the analysis of the content of VWF\\/FVIII concentrates and on pharmacokinetic studies in patients with different severity of VWD (type 1, type 2 or type 3). The VW\\/FVIII concentrates should be

Jan Jacques Michiels; Huub H. D. M. van Vliet; Zwi Berneman; Wilfried Schroyens; Alain Gadisseur

2009-01-01

395

A novel family with recessive von Willebrand disease due to compound heterozygosity for a splice site mutation and a missense mutation in the von Willebrand factor gene  

Microsoft Academic Search

We report a new family with autosomal recessive von Willebrand disease (VWD) in which the propositus was compound heterozygous for a missense mutation in exon 42 (G7085T, C2362F) and a C?A splice site mutation in intron 13 of the von Willebrand factor (VWF) gene. The propositus had factor VIII:C ?20 IU\\/dl, VWF antigen 5–7 IU\\/dl and ristocetin cofactor activity 15

Giancarlo Castaman; Elisabetta Novella; Evelina Castiglia; Jeroen C. J Eikenboom; Francesco Rodeghiero

2002-01-01

396

Quantitative Methods of Edge Detection.  

National Technical Information Service (NTIS)

Most local operators used in edge detection can be modelled by one of two methods: edge enhancement/thresholding and edge fitting. This dissertation presents a quantitative design and performance evaluation of these methods. The design techniques are base...

I. E. Abdou

1978-01-01

397

Verification of Quantitative Maintainability Requirements.  

National Technical Information Service (NTIS)

This document develops basic concepts for treating Maintainability quantitatively, with particular attention devoted to probabilistic aspects. It focuses on the special characteristics of the Lognormal Distribution as they relate to specifying and demonst...

G. Grippo R. M. DeMilia

1965-01-01

398

John von Neumann: the founding father of artificial life.  

PubMed

Aside from being known for his contributions to mathematics and physics, John von Neumann is considered one of the founding fathers of computer science and engineering. Not only did he do pioneering work on sequential computing systems, but he also carried out a major investigation of parallel architectures, leading to his work on cellular automata. His exceptional vision and daring, borrowing from biology the concept of genomic information even before the discovery of DNA's double helix, led him to propose the concept of self-reproducing automata. PMID:9864437

Marchal, P

1998-01-01

399

Veränderungen von peripheren Blutzellpopulationen bei HNO-Karzinompatienten  

Microsoft Academic Search

Zusammenfassung Fragestellung Ziel war die Quantifizierung wesentlicher Leukozyten-\\/Lymphozytenpopulationen im peripheren Blut bei Patienten mit einem HNO-Plattenepithelkarzinom vor und bis lange Zeit nach Therapie. Patienten und Methodik Mittels Flowzytometrie wurden im Blut von 346 Patienten und 31 Kontrollpersonen T-Lymphozyten und NK-Zellen quantifiziert, davon bei 248 Probanden zusätzlich Leukozyten, Monozyten, Granulozyten, Lymphozyten, CD4+- und CD8+-Lymphozyten, CD4+8+-Lymphozyten, B-Lymphozyten, aktivierte T-Lymphozyten, NK-Zellen und CD3+56+-T-Lymphozyten.

J. Ostwald; S. Dommerich; U. Schulz; B. Kramp

2004-01-01

400

von Kármán vortex street within an impacting drop.  

PubMed

The splashing of a drop impacting onto a liquid pool produces a range of different sized microdroplets. At high impact velocities, the most significant source of these droplets is a thin liquid jet emerging at the start of the impact from the neck that connects the drop to the pool. We use ultrahigh-speed video imaging in combination with high-resolution numerical simulations to show how this ejecta gives way to irregular splashing. At higher Reynolds numbers, its base becomes unstable, shedding vortex rings into the liquid from the free surface in an axisymmetric von Kármán vortex street, thus breaking the ejecta sheet as it forms. PMID:23004991

Thoraval, Marie-Jean; Takehara, Kohsei; Etoh, Takeharu Goji; Popinet, Stéphane; Ray, Pascal; Josserand, Christophe; Zaleski, Stéphane; Thoroddsen, Sigurdur T

2012-06-29

401

Inadequacy of von Neumann entropy for characterising extractable work  

NASA Astrophysics Data System (ADS)

The lack of knowledge an observer has about a system limits the amount of work it can extract. This lack of knowledge is normally quantified using the Shannon/von Neumann entropy. We show that this standard approach is, surprisingly, only correct in very specific circumstances. In general one should use the recently developed smooth entropy approach. For many common physical situations, including large but internally correlated systems, the resulting values for the extractable work can deviate arbitrarily from those suggested by the standard approach. (For details see arXiv:0908.0424)

Dahlsten, Oscar; Renner, Renato; Rieper, Elisabeth; Vedral, Vlatko

2011-03-01

402

Inadequacy of von Neumann entropy for characterizing extractable work  

NASA Astrophysics Data System (ADS)

The lack of knowledge that an observer has about a system limits the amount of work it can extract. This lack of knowledge is normally quantified using the Gibbs/von Neumann entropy. We show that this standard approach is, surprisingly, only correct in very specific circumstances. In general, one should use the recently developed smooth entropy approach. For many common physical situations, including large but internally correlated systems, the resulting values for the extractable work can deviate arbitrarily from those suggested by the standard approach.

Dahlsten, Oscar C. O.; Renner, Renato; Rieper, Elisabeth; Vedral, Vlatko

2011-05-01

403

Subunit composition of plasma von Willebrand factor. Cleavage is present in normal individuals, increased in IIA and IIB von Willebrand disease, but minimal in variants with aberrant structure of individual oligomers (types IIC, IID, and IIE).  

PubMed Central

We have evaluated the subunit composition of plasma von Willebrand factor (vWF) and found evidence that cleavage is present in normal individuals, increased in IIA and IIB von Willebrand disease (vWD), but decreased or absent in variants with aberrant structure of individual oligomers. vWF was rapidly purified from plasma on an analytical scale by monoclonal antibody immunoaffinity chromatography in the presence of protease inhibitors. After reduction and electrophoresis in 5% polyacrylamide gels containing sodium dodecyl sulfate, fragments of 189, 176, and 140 kD, as well as the predominant 225-kD subunit, were identified in plasma vWF from 25 normal individuals. The vWF polypeptides were detected by immunoblotting with a mixture of 55 anti-vWF monoclonal antibodies followed by 125I-rabbit anti-mouse antibody and autoradiography. In five individuals with type IIA and five individuals with type IIB vWD, the proportions of 176 and 140-kD fragments were increased relative to the intact 225-kD subunit, as determined by excising each band and quantitating incorporated radioactivity. In contrast, these fragments were either not detectable or were present in only trace amounts in variants with abnormal structure of individual oligomers (types IIC and IID, and a new variant, type IIE vWD). The results reported here provide evidence that absence of large vWF multimers in these two groups of variants results from different mechanisms. In addition, they demonstrate that partial cleavage of the plasma vWF subunit is a normal event. Images

Zimmerman, T S; Dent, J A; Ruggeri, Z M; Nannini, L H

1986-01-01

404

Developing Geoscience Students' Quantitative Skills  

NASA Astrophysics Data System (ADS)

Sophisticated quantitative skills are an essential tool for the professional geoscientist. While students learn many of these sophisticated skills in graduate school, it is increasingly important that they have a strong grounding in quantitative geoscience as undergraduates. Faculty have developed many strong approaches to teaching these skills in a wide variety of geoscience courses. A workshop in June 2005 brought together eight faculty teaching surface processes and climate change to discuss and refine activities they use and to publish them on the Teaching Quantitative Skills in the Geosciences website (serc.Carleton.edu/quantskills) for broader use. Workshop participants in consultation with two mathematics faculty who have expertise in math education developed six review criteria to guide discussion: 1) Are the quantitative and geologic goals central and important? (e.g. problem solving, mastery of important skill, modeling, relating theory to observation); 2) Does the activity lead to better problem solving? 3) Are the quantitative skills integrated with geoscience concepts in a way that makes sense for the learning environment and supports learning both quantitative skills and geoscience? 4) Does the methodology support learning? (e.g. motivate and engage students; use multiple representations, incorporate reflection, discussion and synthesis) 5) Are the materials complete and helpful to students? 6) How well has the activity worked when used? Workshop participants found that reviewing each others activities was very productive because they thought about new ways to teach and the experience of reviewing helped them think about their own activity from a different point of view. The review criteria focused their thinking about the activity and would be equally helpful in the design of a new activity. We invite a broad international discussion of the criteria(serc.Carleton.edu/quantskills/workshop05/review.html).The Teaching activities can be found on the Teaching Quantitative Skills in the Geosciences website (serc.Carleton.edu/quantskills/). In addition to the teaching activity collection (85 activites), this site contains a variety of resources to assist faculty with the methods they use to teach quantitative skills at both the introductory and advanced levels; information about broader efforts in quantitative literacy involving other science disciplines, and a special section of resources for students who are struggling with their quantitative skills. The site is part of the Digital Library for Earth Science Education and has been developed by geoscience faculty in collaboration with mathematicians and mathematics educators with funding from the National Science Foundation.

Manduca, C. A.; Hancock, G. S.

2005-12-01

405

A two-centre comparative evaluation of new automated assays for von Willebrand factor ristocetin cofactor activity and antigen.  

PubMed

von Willebrand disease (VWD) is caused by a quantitative and/or qualitative deficiency of the von Willebrand factor (VWF). The laboratory diagnosis of VWD is dependent on the measurement of VWF antigen (VWF:Ag) and ristocetin cofactor activity (VWF:RCo). The aim of this study was to undertake a two-centre evaluation of two new automated VWF:Ag and VWF:RCo assays systems from Instrumentation Laboratory (Bedford, USA). Using the two new analytical systems that operated with different detection principles: immunoturbidimetric (TOP500 analyser) and chemiluminescent (AcuStar analyser), VWF:Ag and VWF:RCo levels were determined in samples from 171 healthy normal subjects, 80 VWD patients (16 type 1, 58 type 2 and 6 type 3) and 7 acquired von Willebrand syndrome patients. With commercial lyophilized normal and pathological plasmas VWF: Ag and VWF:RCo assays performed on both analysers exhibited low levels of inter-assay imprecision (AcuStar: CV% range 3.3-6.9; TOP500: CV% range 2.6-6.3). Samples from normal healthy subjects (range: VWF:Ag 44.6-173.9 IU dL(-1) ; VWF:RCo 43.1-191.5 IU dL(-1)) and patients (range: VWF:Ag <0.3-115.1 IU dL(-1) ; VWF:RCo <0.5-57.2 IU dL(-1)) showed a good correlation between the two VWF:Ag and VWF:RCo methods (rs = 0.92 and 0.82 respectively), with only a few inconsistent cases among the patients' samples evaluated. The chemiluminescent assays had a lower limit of detection for both VWF:Ag and VWF:RCo compared to immunoturbidimetric tests (0.3 IU dL(-1) vs. 2.2 IU dL(-1) and 0.5 IU dL(-1) vs. 4.4 IU dL(-1) respectively). The TOP500 and AcuStar VWF:Ag and VWF:RCo assays were precise and compare well between centres, making these systems suitable for the diagnosis of VWD in non-specialized and reference laboratories. PMID:24028703

Stufano, F; Lawrie, A S; La Marca, S; Berbenni, C; Baronciani, L; Peyvandi, F

2014-01-01

406

Establishment and characterization of a new and stable collagen-binding assay for the assessment of von Willebrand factor activity  

PubMed Central

Introduction Laboratory diagnosis of von Willebrand disease (VWD) requires determination of both von Willebrand factor (VWF) protein levels and activity. Current VWF activity tests include the ristocetin cofactor assay and the collagen-binding assay (VWF:CB). The goal of this investigation is to characterize a new collagen-binding assay and to determine its effectiveness in identifying VWD. Methods Analytical studies were carried out to characterize the performance of a new VWF:CB ELISA. Additionally, samples from a normal population were tested as were well-characterized type 1 and type 2 VWD samples. Results Repeatability and within-laboratory precision studies resulted in coefficients of variation (CVs) of ?11%. A linear range of 1–354% (0.01–3.54 IU/mL) was determined, along with a limit of detection and a lower limit of quantitation of 1.6% and 4.0% (0.016 and 0.04 IU/mL), respectively. Samples tested from apparently healthy individuals resulted in a normal range of 54–217% (0.54–2.17 IU/mL). Known VWD type 1 and type 2 samples were also analyzed by the ELISA, with 99% of samples having VWF:CB below the normal reference range and an estimated 96% sensitivity and 87% specificity using a VWF collagen-binding/antigen cutoff ratio of 0.50. Conclusion This new VWF:CB ELISA provides an accurate measure of collagen-binding activity that aids in the diagnosis and differentiation of type 1 from type 2 VWD.

Ni, Y; Nesrallah, J; Agnew, M; Geske, F J; Favaloro, E J

2013-01-01

407

Prophylaxis of bleeding episodes in patients with von Willebrand's disease  

PubMed Central

Patients with severe forms of von Willebrand’s disease (VWD) may have frequent haemarthroses, especially when factor VIII (FVIII) levels are below 10 U/dL, so that some of them develop target joints like patients with severe haemophilia A. Some patients have recurrent gastrointestinal bleeding, often without lesions in the gastrointestinal tract, and need treatment every day or every other day. Finally, there are children who have epistaxis frequently and severely enough to cause anaemia. In these frequent and severe bleeders, the optimal therapy may be secondary long-term prophylaxis with von Willebrand factor (VWF)/FVIII concentrates rather than on-demand treatment on the occasion of bleeding episodes. The largest experience on such prophylaxis in VWD has been in Sweden in 35 patients with severe forms of VWD. Long-term prophylaxis was also implemented in a cohort of Italian patients with VWD: prophylaxis was used in seven patients with types 3 (n=1), 2A (n=4), 2M (n=1) and type 1 (n=1) VWD because of recurrent gastrointestinal bleeds and in four patients with type 3 VWD because of joint bleeds. Prophylaxis prevented bleeding completely in eight patients and largely reduced hospitalisation for blood transfusions in the remaining three. The cost-effectiveness of these prophylaxis regimens versus on-demand therapy will now be investigated in one large international study.

Federici, Augusto B.

2008-01-01

408

A visit paid to Jung by Alwine von Keller.  

PubMed

In the winter of 1943-1944, Jung had suffered a coronary thrombosis which almost cost him his life. During his illness, Jung experienced a series of visions, described in his Memories, Dreams, Reflections, which were also to influence significantly the development of his theoretical thinking. On 27(th) September 1944, Alwine von Keller (1878-1965) paid a visit to Jung, while he was still convalescing, in Zurich and documented her meeting with him in a series of notes, recently discovered, which testify to the fact that, at the time of their meeting, Jung was engaged in writing the 'Salt' chapter of Mysterium coniunctionis and investigating the alchemistic symbolism of the 'sea'. This theme seems to testify to a continuity of interests on Jung's part with the seminar he held at Eranos the previous year on the cartographic art of Opicinus de Canistris (1296-c.1352). With its addition of many unpublished details, Alwine von Keller's notes supplement the report which Jung made of his visions experienced during his sickness in MDR. In particular, these attest to the fact that Jung had attributed the terrible experience which he had endured to the problem of the conjunctio, which was confronting him from the theoretical point of view in his writing of Mysterium coniunctionis. PMID:21434902

Bernardini, Riccardo; Quaglino, Gian Piero; Romano, Augusto

2011-04-01

409

Gastrointestinal bleeding, angiodysplasia, cardiovascular disease, and acquired von Willebrand syndrome.  

PubMed

Recent evidence points to isolated deficiency of the largest multimers of von Willebrand factor (VWF)-known as von Willebrand syndrome type 2A (VWS-2A)-as a risk factor for bleeding from gastrointestinal (GI) angiodysplasia. This disorder is not widely recognized, perhaps because most patients do not exhibit generalized hemostatic impairment (bleeding is generally restricted to GI angiodysplasia) and because all but the largest multimers of VWF remain detectable in the plasma (thus, routine screening tests for VWS-2A are usually normal). The "Rosetta stone" for elucidating this syndrome was the enigma of Heyde's syndrome (aortic stenosis plus bleeding GI angiodysplasia), particularly the striking observation that aortic valve replacement generally cures GI bleeding and that preoperative deficiency of the largest VWF multimers undergoes long-term normalization after valve replacement. We critically review the evidence implicating VWS-2A as a risk factor for bleeding GI angiodysplasia. We hypothesize that VWS-2A secondary to cardiovascular disease other than severe aortic stenosis, such as peripheral arterial occlusive disease, could explain why elderly patients often develop recurrent GI bleeding or iron deficiency anemia from GI angiodysplasia. PMID:14571395

Warkentin, Theodore E; Moore, Jane C; Anand, Sonia S; Lonn, Eva M; Morgan, David G

2003-10-01

410

Quantitation of Microorganisms in Sputum  

PubMed Central

A method of quantitating microbial cultures of homogenized sputum has been devised. Possible application of this method to the problem of determining the etiologic agent of lower-respiratory-tract infections has been studied to determine its usefulness as a guide in the management of these infections. Specimens were liquefied by using an equal volume of 2% N-acetyl-L-cysteine. The liquefied sputum suspension was serially diluted to 10-1, 10-3, 10-5, and 10-7. These dilutions were plated on appropriate media by using an 0.01-ml calibrated loop; they were incubated and examined by standard diagnostic methods. Quantitation of fresh sputum from patients with pneumonia prior to antimicrobial therapy revealed that probable pathogens were present in populations of 107 organisms/ml or greater. Normal oropharyngeal flora did not occur in these numbers before therapy. Comparison of microbial counts on fresh and aged sputum showed that it is necessary to use only fresh specimens, since multiplication or death alters both quantitative and qualitative findings. Proper collection and quantitative culturing of homogenized sputum provided information more directly applicable to patient management than did qualitative routine methods. Not only was the recognition of the probable pathogenic organism in pneumonia patients improved, but serial quantitative cultures were particularly useful in recognizing the emergence of superinfections and in evaluating the efficacy of antimicrobial therapy.

Monroe, P. W.; Muchmore, H. G.; Felton, F. G.; Pirtle, J. K.

1969-01-01

411

von Willebrand factor mutation enhancing interaction with platelets in patients with normal multimeric structure.  

PubMed Central

Variant von Willebrand disease designated as type I New York or type Malmö is characterized by enhanced ristocetin-induced platelet agglutination with normal von Willebrand factor multimeric distribution in plasma. We have studied four such patients belonging to three unrelated families and found in all of them a unique cytosine-to-thymine transition changing the codon for Pro503 (CCG) to Leu (CTG). In three patients the mutant allele also had a silent mutation in the codon for Ser500 (TCG-->TCA). Both nucleotide changes are present in the von Willebrand factor pseudogene; however, the characterization of distinctive markers where the gene and pseudogene differ, as well as the examination of amplified cDNA derived from platelet mRNA, confirmed that the abnormality occurs in the von Willebrand factor gene of the patients. Moreover, recombinant expression of the isolated glycoprotein Ib-binding domain of von Willebrand factor provided direct evidence that the Pro503-->Leu mutation is responsible for enhanced platelet reactivity to lower ristocetin concentrations. These results define a new structural element affecting the affinity of von Willebrand factor for glycoprotein Ib and establish the molecular basis of a variant form of von Willebrand disease. Images

Holmberg, L; Dent, J A; Schneppenheim, R; Budde, U; Ware, J; Ruggeri, Z M

1993-01-01

412

Visualizing the von Willebrand factor/glycoprotein Ib-IX axis with a platelet-type von Willebrand disease mutation.  

PubMed

Platelet-type von Willebrand disease (PT-VWD) is a bleeding disorder of the platelet glycoprotein Ib-IX/von Willebrand factor (VWF) axis caused by mutations in the glycoprotein Ib-IX receptor that lead to an increased affinity with VWF. In this report, platelets from a mouse expressing a mutation associated with PT-VWD have been visualized using state-of-the art image collection and processing. Confocal analysis revealed that VWF bound to the surface of single platelets and bridging micro-aggregates of platelets. Surface-bound VWF appears as a large, linear structure on the surface of 50% of the PT-VWD platelets. In vivo thrombus formation after chemical injury to the carotid artery revealed a severe impairment to occlusion as a consequence of the PT-VWD mutation. In vitro stimulation of PT-VWD platelets with adenosine diphosphate or thrombin demonstrates a significant block in their ability to bind fibrinogen. The impairment of in vivo thrombus formation and in vitro fibrinogen binding are more significant than might be expected from the observed platelet binding to VWF polymers over a small portion of the plasma membrane. Visualization of the receptor/ligand interaction and characterization of a severe antithrombotic phenotype provide a new understanding on the molecular basis of bleeding associated with the PT-VWD phenotype. PMID:19808696

Guerrero, Jose A; Kyei, Mark; Russell, Susan; Liu, Junling; Gartner, T Kent; Storrie, Brian; Ware, Jerry

2009-12-24

413

Characterization of a novel mutation in the von Willebrand factor propeptide in a distinct subtype of recessive von Willebrand disease.  

PubMed

von Willebrand factor (VWF) is a plasma protein that consists of a series of multimers of which the high-molecular-weight VWF multimers are the most potent in platelet adhesion and aggregation. The propeptide of the VWF (VWFpp) is known to be essential in the process of multimer assembly. Genetic studies were performed in a patient with a phenotype of von Willebrand disease (VWD) characterized by very low plasma factor VIII and VWF levels and a VWF consisting of only a dimeric band and total absence of all multimers in plasma. The patient was found to be homozygous for the novel C570S mutation, caused by a 1709G>C transition in exon 14 of the VWF gene coding for the propeptide. Three asymptomatic relatives were found to be heterozygous. In-vitro mutagenesis and expression in COS-7 cells confirmed the detrimental effect of the mutation on VWF multimerization. Our findings show that the C570S mutation in the VWFpp abolishes multimerization of VWF. The mutation probably disrupts the normal configuration of the VWFpp, which is essential for correct orientation of the protomers and ultimately multimerization. The mutant amino acid is located in a region that is highly conserved across several species which underlines its critical role. This variant constitutes a distinct subtype of recessive 2A VWD with the exclusive presence of the dimeric form of VWF in plasma. PMID:18690339

Lanke, Elsa; Kristoffersson, Ann-Charlotte; Philips, Malou; Holmberg, Lars; Lethagen, Stefan

2008-08-01

414

[Biologic artifacts in quantitative EEG].  

PubMed

We studied the influence of five biologic artifacts sources on quantitative EEG (blinking, forced eyes closure, forced jaw closure, tongue movements and pursuit eyes movements) through both visual and spectral analysis, with the purpose of verifying how do these artifacts can be seen in a cartographic way. We found that the spectrums potentials showed the same topographic display that was found through visual analysis. Visual analysis was superior than the quantitative evaluation to recognise the artifacts, as the former preserved the morphological display of the paroxysms. However it is important know how do the potentials are represented in quantitative maps, so that they can be identified as artifacts and not as pathologic EEG activity. PMID:16791367

Anghinah, Renato; Basile, Luis I; Schmidt, Magali T; Sameshima, Koichi; Gattaz, Wagner Farid

2006-06-01

415

Von Willebrand Factor, Red Cell Fragmentation, and Disease Activity in Systemic Lupus Erythematosus  

PubMed Central

This study sought to determine whether the plasma levels of Von Willebrand factor (vWf) and the degree of red blood cell (RBC) fragmentation on peripheral smear correlate with disease activity in systemic lupus erythematosus (SLE). Forty consecutive patients who fulfilled the criteria for SLE were studied prospectively for 1 year. Patients were categorized according to the SLE Disease Activity Index (SLEDAI) as either active (>2) or inactive disease and followed up monthly (active) or quarterly (inactive). At each visit, patients were examined fully and had complete blood count, tests on antibodies to double-stranded DNA, C3, and C4 levels, and urinalysis. Citrated plasma was analyzed for vWf antigen by standard enzyme-linked immunosorbent assay. A Wright’s stained blood smear was obtained and schistocytes were quantitated on blood smear. The number of schistocytes per 500 RBCs was determined and a schistocyte index (SI) was calculated. At baseline, vWf correlated with SLEDAI (r?=?0.64, p?

Bhagati, Rajkumari; Basavaraju, Lakshmi; Norton, Delona; Katz, James; Haile, Elizabeth; Weinstein, Arthur

2008-01-01

416

Von Willebrand Factor permeates small vessels in CADASIL and inhibits smooth muscle gene expression  

PubMed Central

Background and Purpose CADASIL (cerebral autosomal dominant arteriopathy subcortical infarcts and leukoencephalopathy) is a genetic disorder hallmarked by ischemic stroke and vascular dementia. Characteristic pathological changes in the vasculature include thickening of small arteries and accumulation of heterogeneous material within the vessel wall. We tested whether endothelial von Willebrand factor (vWF) accumulates in CADASIL vessels and whether exposure of smooth muscle cells to vWF alters the expression of smooth muscle gene expression. Methods Brain sections obtained at autopsy from six North American CADASIL patients were examined using immunohistochemistry for vWF and IgG. Rat aortic smooth muscle cells (A7R5 cells) were tested for binding to infrared-tag labeled vWF. Finally, A7R5 cells were exposed to vWF, and expression of mature smooth muscle marker genes was analyzed by quantitative reverse transcriptase PCR. Results vWF is expressed in the penetrating arterial walls in all CADASIL samples. IgG, a marker of serum extravasation, was present only in a minority of arterial walls. vWF binds to smooth muscle cells in vitro, and low concentrations of vWF rapidly activate c-fos, EGR, TSP1, and c-myc while specifically inhibiting RNA encoding smooth muscle actin, calponin, and SM22. Conclusions These data demonstrate that vWF, likely produced by the endothelium, permeates the vessel wall of CADASIL brains. Exposure of smooth muscle cells to vWF results in reduction of specific RNAs required for normal vascular homeostasis. This is the first report of accumulation of a protein within CADASIL vessels that inhibits vascular gene expression and implicates a role for vWF beyond hemostasis.

Zhang, Xiaojie; Meng, He; Blaivas, Mila; Rushing, Elisabeth J.; Moore, Brian E.; Schwartz, Jessica; Lopes, M. Beatriz S.; Worrall, Bradford B.; Wang, Michael M.

2011-01-01

417

The influence of von Willebrand factor on factor VIII activity measurements  

PubMed Central

Summary Background It has been reported by multiple laboratories that the quantitation of factor (F)VIII by activity-based assays is influenced by the method, procedure and the quality of reagents used in the assays. Objective To evaluate the influence of von Willebrand factor (vWF) on FVIII activity in vitro. Methods The APTT and synthetic coagulation proteome assays were used. Citrated FVIII/vWF-depleted substrate plasma (SP; both antigens <0.5%) was used in all APTT assays. Results The concentration of FVIII antigen in pooled plasma from healthy donors (NP) was 1.5 nM. The SP reconstituted with 1.5 nM recombinant (r)FVIII clotted in 23.8±0.2 s (S.D.). The addition of 10 ?g/ml vWF to the SP increased the clotting time to 28.7±0.1 s, i.e. the activity of rFVIII (FVIIc) decreased to 50%. This inhibitory effect of vWF decreased with decreasing rFVIII concentration in SP and became negligible at rFVIII ?10% (150 pM). The FVIIIc of 1.5 nM FVIII in two products formulated with vWF (Immunate and Hemofil M) was not affected by the addition of exogenous vWF to the SP, whereas the FVIIIc of the B-domainless rFVIII product ReFacto was decreased 64% by the addition of vWF. In the synthetic coagulation proteome triggered with 5 pM tissue factor, vWF had no effect on thrombin generation. Conclusions vWF has an inhibitory effect on the measurement of FVIII clotting activity. This effect depends upon the structure and formulation of the FVIII product.

BUTENAS, S.; PARHAMI-SEREN, B.; MANN, K.G.

2012-01-01

418

Gesellschaft, Lebensgemeinschaft, Ökosystem - Über die Kongruenz von politischen und ökologischen Theorien der Entwicklung  

NASA Astrophysics Data System (ADS)

Im Jahr 1859 veröffentlichte Charles Darwin "On the Origin of Species“. Seine Evolutionstheorie ist das wohl spektakulärste Beispiel einer naturwissenschaftlichen Theorie großer gesellschaftlicher Relevanz. Ihre verschiedenen Facetten wurden in der Öffentlichkeit kontrovers diskutiert, unter anderem auch ihre Anwendung zur Erklärung von Zuständen und Prozessen menschlicher Gesellschaften. Zum Teil wurde die Seiensweise der Natur - scheinbar unabhängig von gesellschaftlichen Interessen - für die Erklärung und Legitimation gesellschaftlicher Zustände oder die Legitimation von politischen Ideologien herangezogen (Sozialdarwinismus). Denn Gesellschaft funktioniere ja so, wie Darwin die Natur erklärt habe: es herrsche z. B. Konkurrenzkampf, Auslese und Arbeitsteilung, Erfolg hätten diejenigen, die sich an die Bedingungen am Besten anpassten.

Voigt, Annette

419

Robuste Verzweigungserkennung von Gefäßen in CTA-Datensätzen zur modellbasierten Extraktion der Centerline  

NASA Astrophysics Data System (ADS)

Bei der Befundung und Visualisierung von Blutgefäßen ist deren Centerline von zentraler Bedeutung. Die Unterscheidung zwischen unverzweigten Abschnitten des Gefäßes und Verzweigungsbereichen ermöglicht den Einsatz spezialisierter und sehr effizienter Algorithmen zur modellbasierten Extraktion der Centerline. In diesem Artikel wird ein robustes Verfahren zur Verzweigungserkennung vorgestellt. Das Verfahren beruht auf einem Front-Propagation-Ansatz mit dynamisch angepassten Schwellwerten und einer anschließenden Clusteranalyse. Die vorgestellte Methode zur Verzweigungserkennung wurde als Komponente einer Architektur zur Extraktion der Centerline auf handannotierten Datensätzen getestet. Erste Ergebnisse sind sehr vielversprechend und ermöglichen auch bei pathologischen Gefäßen eine robuste Detektion von Gefäßverzweigungen.

Beck, Thomas; Fritz, Dominik; Biermann, Christina; Dillmann, Rüdiger

420

Leistungsmodellierung als Voraussetzung für Produktionsplanung und -steuerung (PPS) für die Bereitstellung von IT-Services  

Microsoft Academic Search

\\u000a Steigender Kostendruck und zunehmende Dienstleistungsorientierung erfordern ein Umdenken beim Einsatz von Methoden zum Management\\u000a der Bereitstellung von IT-Services. Wurden in der Vergangenheit primär Projektmanagementmethoden genutzt, rücken mit zunehmender\\u000a IT-Service-Standardisierung Methoden aus der Sachgüterfertigung in den Mittelpunkt. In diesem Beitrag wird dargestellt, welche\\u000a Möglichkeiten und Grenzen industrielle Produktionsplanungs- und -steue-rungssysteme für die Bereitstellung von IT-Services\\u000a am konkreten Fallbeispiel der „Global Delivery

Alexander Vogedes; Nico Ebert; Henrik Brocke; Falk Uebernickel; Walter Brenner

421

On conjugate families and Jeffreys priors for von Mises-Fisher distributions  

PubMed Central

This paper discusses characteristics of standard conjugate priors and their induced posteriors in Bayesian inference for von Mises–Fisher distributions, using either the canonical natural exponential family or the more commonly employed polar coordinate parameterizations. We analyze when standard conjugate priors as well as posteriors are proper, and investigate the Jeffreys prior for the von Mises–Fisher family. Finally, we characterize the proper distributions in the standard conjugate family of the (matrix-valued) von Mises–Fisher distributions on Stiefel manifolds.

Hornik, Kurt; Grun, Bettina

2013-01-01

422

Quantum Enveloping Algebras with von Neumann Regular Cartan-like Generators and the Pierce Decomposition  

Microsoft Academic Search

Quantum bialgebras derivable from U\\u000a \\u000a q\\u000a (sl\\u000a 2) which contain idempotents and von Neumann regular Cartan-like generators are introduced and investigated. Various types\\u000a of antipodes (invertible and von Neumann regular) on these bialgebras are constructed, which leads to a Hopf algebra structure\\u000a and a von Neumann-Hopf algebra structure, respectively. For them, explicit forms of some particular R-matrices (also, invertible and

Steven Duplij; Sergey Sinel'Shchikov

2009-01-01

423

Quantitative intracerebral brain hemorrhage analysis  

NASA Astrophysics Data System (ADS)

In this paper a system for 3-D quantitative analysis of human spontaneous intracerebral brain hemorrhage (ICH) is described. The purpose of the developed system is to perform quantitative 3-D measurements of the parameters of ICH region and from computed tomography (CT) images. The measured parameter in this phase of the system development is volume of the hemorrhage region. The goal of the project is to measure parameters for a large number of patients having ICH and to correlate measured parameters to patient morbidity and mortality.

Loncaric, Sven; Dhawan, Atam P.; Cosic, Dubravko; Kovacevic, Domagoj; Broderick, Joseph; Brott, Thomas

1999-05-01

424

Antigenic Peptides Capable of Inducing Specific Antibodies for Detection of the Major Alterations Found in Type 2B Von Willebrand Disease  

PubMed Central

Von Willebrand disease (VWD) is an inherited hemorrhagic disorder promoted by either quantitative or qualitative defects of the von Willebrand factor (VWF). The disease represents the most common human coagulopathy afflicting 1.3% of the population. Qualitative defects are subdivided into four subtypes and classified according to the molecular dysfunction of the VWF. The differential diagnosis of the VWD is a difficult task, relying on a panel of tests aimed to assess the plasma levels and function of the VWF. Here, we propose biochemical approaches for the identification of structural variants of the VWF. A bioinformatic analysis was conducted to design seven peptides among which three were representatives of specific amino acid sequences belonging to normal VWF and four encompassed sequences found in the most common VWD subtype 2B. These peptides were used to immunize mice, after which, peptide-specific immunoglobulins were purified. This resulted in four Ig preparations capable of detecting alterations in the subtype 2B VWD plus additional three antibody fractions targeting the normal VWF. The panel of antibodies could serve many applications among them (1) assessment of VWF: antigen interaction, (2) VWF multimer analysis, and (3) production of monoclonal antibodies against VWF for therapeutic purposes as in thrombotic thrombocytopenic purpura.

Paro, Marina de Oliveira; Ferreira, Cyntia Silva; Vieira, Fernanda Silva; de Santana, Marcos Aurelio; Namen-Lopes, Maria Sueli Silva; Leclercq, Sophie Yvette; Velloso-Rodrigues, Cibele; Guerra de Andrade, Milton Hercules

2013-01-01

425

Efficacy and safety during formulation switch of a pasteurized VWF/FVIII concentrate: results from an Italian prospective observational study in patients with von Willebrand disease.  

PubMed

Von Willebrand disease (VWD) is an inherited bleeding disorder caused by the quantitative or qualitative deficiency of von Willebrand factor (VWF). Replacement therapy with plasma-derived VWF/factor VIII (FVIII) concentrates is required in patients unresponsive to desmopressin. To assess the efficacy, safety and ease of use of a new, volume-reduced (VR) formulation of VWF/FVIII concentrate Haemate(®) P in patients requiring treatment for bleeding or prophylaxis for recurrent bleeding or for invasive procedures. Pharmacoeconomic variables were also recorded. Data were analysed using descriptive statistics. This was a multicentre, prospective, observational study. Consecutively enrolled patients received Haemate(®) P VR according to their needs, and were followed for 24 months. Of the 121 patients enrolled, 25.6% had type 3 VWD and more than 40% had severe disease. All patients were followed for 2 years, for a total of 521 visits. On-demand treatment was given to 61.9% of patients, secondary long-term prophylaxis to 25.6% and prophylaxis for surgery, dental or invasive procedures to 45.5%. The response to treatment was rated as good to excellent in >93-99% of interventions. The new formulation was well tolerated by all patients with no report of drug-related adverse events. The switch to volume-reduced Haemate(®) P was easy to perform and infusion duration was decreased twofold compared with the previous formulation. Volume-reduced Haemate(®) P was at least as effective and well-tolerated as the previous formulation. PMID:22957493

Castaman, G; Coppola, A; Zanon, E; Boeri, E; Musso, M; Siragusa, S; Federici, A B; Mancuso, G; Barillari, G; Biasoli, C; Feola, G; Franchini, M; Moratelli, S; Gamba, G; Schinco, P; Valdrè, L; Dragani, A; Mazzucconi, G; Tagliaferri, A; Morfini, M

2013-01-01

426

Quantitative aspects of outsourcing deals  

Microsoft Academic Search

There are many goals for outsourcing information technology: for instance, cost reduction, speed to market, quality improvement, or new business opportunities. Based on our real-world experience in advising organizations with goal-driven outsourcing deals, we identified the most prominent quantitative input needed to close such deals. These comprise what we named th efi ve executive issues enabling rational decision making. They

Chris Verhoef

2005-01-01

427

Quantitative Easing: A Keynesian Critique  

Microsoft Academic Search

Keynesian economists have generally supported quantitative easing (QE) on grounds it increases aggregate demand and anything that increases demand at this time of demand shortage is welcome. This paper argues that response may be misplaced. QE may back fire with respect to demand stimulus, create potentially significant future dangers, and is supportive of a plutocratic political economy based on “asset

Thomas I. Palley

2011-01-01

428

When is Quantitative Easing effective?  

Microsoft Academic Search

We present a simple macroeconomic model with open market operations that allows examining the effects of quantitative and credit easing. The central bank controls the policy rate, i.e. the price of money in open market operations, as well as the amount and the type of assets that are accepted as collateral for money. When the policy rate is sufficiently low,

Markus Hoermann; Andreas Schabert

2011-01-01

429

A quantitative approach to cytoarchitectonics  

Microsoft Academic Search

The cerebral cortex of the albino mouse was examined by means of a quantitative method. An image analyzer was used in conjunction with an automatic scanning procedure to determine the grey level index in Nissl-stained sections. Computer plots of various ranges of grey level indices enabled delineation of cortical areas, from which cortical maps were graphically reconstructed.

Andreas Wree; Karl Zilles; Axel Schleicher

1983-01-01

430

Quantitative mineralogical applications of FTIR  

Microsoft Academic Search

FTIR (Fourier Transform Infrared) spectroscopy techniques can be applied to the quantitative estimation of mineral abundances. The method is particularly useful for minerals with unique absorption bands such as those due to OH-stretching in the clay minerals. Overlapping bands, scarcity of standards, and difficulties of sample preparation are the most serious drawbacks of the method. More than 20 clay-mineral separates

A. S. Malatesta; C. Y. Dohmann; R. E. Jr. Ferrell; W. S. Leblanc; M. L. Wood; L. B. Williams

1993-01-01

431

Quantitative studies of vaginal bacteria  

Microsoft Academic Search

A quantitative method of culture, based on a weighed sample and with results expressed as colony forming units (cfu)\\/g was assessed and used to investigate the vaginal flora of normal women and that of women with vaginal disease. Samples were collected by means of disposable plastic loops into modified proteose peptone water transport medium in preweighed bottles. Counts expressed as

A N Masfari; B I Duerden; G R Kinghorn

1986-01-01

432

Quantitative analysis using chromatographic techniques  

SciTech Connect

The book is divided into nine contributed chapters. Chapter 1 is an elementary introduction to the concepts of the chromatographic process. Chapter 2 is a brief discussion of the detectors used in liquid chromatography; many similar and more comprehensive reviews exist. Quantitative measurements in liquid chromatography are discussed in Chapter 3 with examples taken from the author's work. The most popular detectors used in gas chromatography are reviewed in Chapter 4, which is followed by a treatment of quantitative analysis with gas chromatography (Chapter 5). A good portion of Chapter 6 dealing with quantitative thin-layer chromatography is taken from an earlier book by one of the authors, but the discussion of errors is new and more complete than those in Chapter 3 and 5. Chapter 7 deals with the application of quantitative chromatographic methods to the analysis of pharmaceuticals. The desiderata of automated analytical methods are discussed in Chapter 8; it concludes with a discussion of the use of robots for the preparation of samples and the loading of them into otherwise fully automated chromatographic systems. In Chapter 9 an introduction is given to the complex matter of extracting information from the shapes of peaks generated by liquid chromatography.

Katz, E.

1987-01-01

433

A Quantitative Infrared Spectroscopy Experiment.  

ERIC Educational Resources Information Center

Although infrared spectroscopy is used primarily for qualitative identifications, it is possible to use it as a quantitative tool as well. The use of a standard curve to determine percent methanol in a 2,2,2-trifluoroethanol sample is described. Background information, experimental procedures, and results obtained are provided. (JN)

Krahling, Mark D.; Eliason, Robert

1985-01-01

434

Quantitative Research in Written Composition.  

ERIC Educational Resources Information Center

Offered as an introductory guide to teachers interested in approaching written English as a "second dialect" that students must master, this review covers quantitative investigations of written language. The first section deals with developmental studies, describing how a variety of researchers have related written structure to writer maturity.…

Gebhard, Ann O.

435

Local Quantitative LTL Model Checking  

Microsoft Academic Search

Quantitative analysis of probabilistic systems has been stu- died mainly from the global model checking point of view. In the global model-checking, the goal of verification is to decide the probability of satisfaction of a given property for all reachable states in the state space of the system under investigation. On the other hand, in local model checking approach the

Jiri Barnat; Lubos Brim; Ivana Cerná; Milan Ceska; Jana Tumova

2008-01-01

436

The Unreality of Quantitative Figures.  

ERIC Educational Resources Information Center

Recently, a number of quantitative studies have explored systematic relationships between sociocultural organization and patterns of language use, based on the assumption that speech behavior reflects the basic categories of the community's social structure. Such systematic links were arrived at by correlating average group scores for…

Al-Amadidh, Darwish G.

437

Quantitative Models in Marketing Research  

Microsoft Academic Search

Advances in data collection and data storage techniques have enabled marketing researchers to study the individual characteristics of a large range of transactions and purchases, in particular the effects of household-specific characteristics. This 2001 book presents important and practically relevant quantitative models for marketing research. Each model is presented in detail with a self-contained discussion, which includes: a demonstration of

Philip Hans Franses; Richard Paap

2001-01-01

438

Towards quantitative assessment of calciphylaxis  

NASA Astrophysics Data System (ADS)

Calciphylaxis is a rare disease that has devastating conditions associated with high morbidity and mortality. Calciphylaxis is characterized by systemic medial calcification of the arteries yielding necrotic skin ulcerations. In this paper, we aim at supporting the installation of multi-center registries for calciphylaxis, which includes a photographic documentation of skin necrosis. However, photographs acquired in different centers under different conditions using different equipment and photographers cannot be compared quantitatively. For normalization, we use a simple color pad that is placed into the field of view, segmented from the image, and its color fields are analyzed. In total, 24 colors are printed on that scale. A least-squares approach is used to determine the affine color transform. Furthermore, the card allows scale normalization. We provide a case study for qualitative assessment. In addition, the method is evaluated quantitatively using 10 images of two sets of different captures of the same necrosis. The variability of quantitative measurements based on free hand photography is assessed regarding geometric and color distortions before and after our simple calibration procedure. Using automated image processing, the standard deviation of measurements is significantly reduced. The coefficients of variations yield 5-20% and 2-10% for geometry and color, respectively. Hence, quantitative assessment of calciphylaxis becomes practicable and will impact a better understanding of this rare but fatal disease.

Deserno, Thomas M.; Sárándi, István.; Jose, Abin; Haak, Daniel; Jonas, Stephan; Specht, Paula; Brandenburg, Vincent

2014-03-01

439

Chapter 8 Quantitation of Protein  

Microsoft Academic Search

The measurement of protein concentration in an aqueous sample is an important assay in biochemistry research and development labs for applications ranging from enzymatic studies to providing data for biopharmaceutical lot release. Spectrophotometric protein quantitation assays are methods that use UV and visible spectroscopy to rapidly determine the concentration of protein, relative to a standard, or using an assigned extinction

James E. Noble; Marc J. A. Bailey

2009-01-01

440

A Powerful Friendship: Theodore von Karman and Hugh L. Dryden  

NASA Technical Reports Server (NTRS)

During their long personal friendship and professional association, Theodore von Karman (1882-1963) and Hugh L. Dryden (1898-1965) exercised a pivotal if somewhat elusive influence over American aeronautics and spaceflight. Both decisive figures in organizing scientists and engineers at home and abroad, both men of undisputed eminence in their technical fields, their range of contacts in government, academia, the armed forces, industry, and professional societies spanned the globe to an extent unparalleled then as now. Moreover, because they coordinated their activities closely, their combined influence far exceeded the sum of each one s individual contributions. This paper illustrates their personal origins as well as the foundations of their friendship, how their relationship became a professional alliance, and their joint impact on the world of aeronautics and astronautics during the twentieth century.

Gorn, Michael

2003-01-01

441

Voluntarism in early psychology: the case of Hermann von Helmholtz.  

PubMed

The failure to recognize the programmatic similarity between (post-)Kantian German philosophy and early psychology has impoverished psychology's historical self-understanding to a great extent. This article aims to contribute to recent efforts to overcome the gaps in the historiography of contemporary psychology, which are the result of an empiricist bias. To this end, we present an analysis of the way in which Hermann von Helmholtz's theory of perception resonates with Johann Gottlieb Fichte's Ego-doctrine. It will be argued that this indebtedness is particularly clear when focusing on the foundation of the differential awareness of subject and object in perception. In doing so, the widespread reception of Helmholtz's work as proto-positivist or strictly empiricist is challenged, in favor of the claim that important elements of his theorizing can only be understood properly against the background of Fichte's Ego-doctrine. PMID:24818740

De Kock, Liesbet

2014-05-01

442

Von Willebrand factor, ADAMTS13, and thrombotic thrombocytopenic purpura  

PubMed Central

Discoveries during the past decade have revolutionized our understanding of idiopathic thrombotic thrombocytopenic purpura (TTP). Most cases in adults are caused by acquired autoantibodies that inhibit ADAMTS13, a metalloprotease that cleaves von Willebrand factor within nascent platelet-rich thrombi to prevent hemolysis, thrombocytopenia, and tissue infarction. Although approximately 80% of patients respond to plasma exchange, which removes autoantibody and replenishes ADAMTS13, one third to one half of survivors develop refractory or relapsing disease. Intensive immunosuppressive therapy with rituximab appears to be effective as salvage therapy, and ongoing clinical trials should determine whether adjuvant rituximab with plasma exchange also is beneficial at first diagnosis. A major unanswered question is whether plasma exchange is effective for the subset of patients with idiopathic TTP who do not have severe ADAMTS13 deficiency.

2008-01-01

443

von Willebrand factor: an emerging target in stroke therapy  

PubMed Central

Thrombus formation is of paramount importance in the pathophysiology of acute ischemic stroke. Current antithrombotics used to treat or prevent cerebral ischemia are only moderately effective or bear an increased risk of severe bleeding. von Willebrand factor (VWF) has long been known to be a key player in thrombus formation at sites of vascular damage. While the association between VWF and coronary heart disease has been well studied, knowledge about the role of VWF in stroke is much more limited. However, in recent years, an increasing amount of clinical and preclinical evidence has revealed the critical involvement of VWF in stroke development. This review summarizes the latest insights into the pathophysiologic role of VWF-related processes in ischemic brain injury under experimental conditions and in humans. Potential clinical merits of novel inhibitors of VWF-mediated platelet adhesion and activation as powerful and safe tools to combat thromboembolic disorders including ischemic stroke are discussed.

De Meyer, Simon F.; Stoll, Guido; Wagner, Denisa D.; Kleinschnitz, Christoph

2014-01-01

444

Lymphoplasmacytic lymphoma exposed by haemoptysis and acquired von Willebrand syndrome.  

PubMed

We report on a 36-year-old man who presented to the emergency department with haemoptysis. Computed tomography (CT) of the thorax showed a pulmonary mass paramediastinal in the right upper lobe, with the density of a haematoma. Laboratory data demonstrated an absolute lymphocytosis of 5.900?×?10/l (normal range, 1.150-3.250?×?10/l) and a prolonged activated partial thromboplastin time (APTT) of 47.7?s (normal range, 28.0-39.0?s). A de novo diagnosis of lymphoplasmacytic lymphoma (Waldenström macroglobulinaemia) was made, complicated by an acquired von Willebrand syndrome (aVWS) as demonstrated by further laboratory investigations. In this case report, we present a case of aVWS with markedly prolonged APTT and haemoptysis that revealed an underlying Waldenström macroglobulinaemia. PMID:24469392

Coucke, Line; Marcelis, Ludo; Deeren, Dries; Van Dorpe, Jo; Lambein, Kathleen; Devreese, Katrien

2014-06-01

445

The von Hippel-Lindau gene: turning discovery into therapy.  

PubMed

Mutations or aberrations of the von Hippel-Lindau gene are responsible for the hereditary neoplastic syndrome that bears the same name, as well as for the majority of sporadic clear cell renal cell carcinomas. The discovery of this gene and subsequent clarification of its mechanism of action have led to a series of targeted treatments for advanced kidney cancer and have dramatically changed how we manage this disease. The discovery of the VHL gene is a prime example of how discoveries at the bench can inform and revolutionize therapeutics at the bedside. In this review, the authors trace this illuminating tale, from the cloning of the VHL gene, to elucidating its biologic function, to the development of novel therapeutics that have dramatically changed the paradigm of managing advanced renal cell carcinoma. PMID:18800388

Clark, Peter E; Cookson, Michael S

2008-10-01

446

Dr. von Braun Standing by Five F-1 Engines  

NASA Technical Reports Server (NTRS)

A pioneer of America's space program, Dr. von Braun stands by the five F-1 engines of the Saturn V launch vehicle. This Saturn V vehicle is an actual test vehicle which has been displayed at the U.S. Space Rocket Center in Huntsville, Alabama. Designed and developed by Rocketdyne under the direction of the Marshall Space Flight Center, a cluster of five F-1 engines was mounted on the Saturn V S-IC (first) stage. The engines measured 19-feet tall by 12.5-feet at the nozzle exit and burned 15 tons of liquid oxygen and kerosene each second to produce 7,500,000 pounds of thrust. The S-IC stage is the first stage, or booster, of a 364-foot long rocket that ultimately took astronauts to the Moon.

2004-01-01

447

Terminal Platelet Production is Regulated by Von Willebrand Factor  

PubMed Central

It is established that proplatelets are formed from mature megakaryocytes (MK) as intermediates before platelet production. Recently, the presence of proplatelets was described in blood incubated in static conditions. We have previously demonstrated that platelet and proplatelet formation is upregulated by MK exposure to high shear rates (1800 s?1) on immobilized von Willebrand factor (VWF). The purpose of the present study was to investigate whether VWF is involved in the regulation of terminal platelet production in blood. To this end, Vwf ?/? mice, a model of severe von Willebrand disease, were used to create a situation in which blood cells circulate in a vascular tree that is completely devoid of VWF. Murine platelets were isolated from Vwf ?/? and Vwf +/+ blood, exposed to VWF at 1800 s?1 in a microfluidic platform, and examined by means of videomicroscopy, as well as fluorescence and activation studies. Proplatelets became visible within 5 minutes, representing 38% of all platelets after 12 minutes and 46% after 28 min. The proportion of proplatelets was 1.8-fold higher in blood from Vwf?/? mice than from Vwf+/+ mice, suggesting a role of VWF in vivo. Fragmentation of these proplatelets into smaller discoid platelets was also observed in real-time. Platelets remained fully activatable by thrombin. Compensation of plasmatic VWF following hydrodynamic gene transfer in Vwf?/? mice reduced the percentage of proplatelets to wild-type levels. A thrombocytopenic mouse model was studied in the flow system, 7 days after a single 5-FU injection. Compared to untreated mouse blood, a 2-fold increase in the percentage of proplatelets was detected following exposure to 1800 s?1 on VWF of samples from mice treated with 5-FU. In conclusion, VWF and shear stress together appear to upregulate proplatelet reorganization and platelet formation. This suggests a new function for VWF in vivo as regulator of bloodstream thrombopoiesis.

Poirault-Chassac, Sonia; Nguyen, Kim Anh; Pietrzyk, Audrey; Casari, Caterina; Veyradier, Agnes; Denis, Cecile V.; Baruch, Dominique

2013-01-01

448

John von Neumann and Klaus Fuchs: an Unlikely Collaboration  

NASA Astrophysics Data System (ADS)

I discuss the origin of the idea of making a fusion (hydrogen) bomb and the physics involved in it, and then turn to the design proposed for one by the unlikely collaborators John von Neumann and Klaus Fuchs in a patent application they filed at Los Alamos in May 1946, which Fuchs passed on to the Russians in March 1948, and which with substantial modifications was tested on the island of Eberiru on the Eniwetok atoll in the South Pacific on May 8, 1951. This test showed that the fusion of deuterium and tritium nuclei could be ignited, but that the ignition would not propagate because the heat produced was rapidly radiated away. Meanwhile, Stanislaw Ulam and C.J. Everett had shown that Edward Teller’s Classical Super could not work, and at the end of December 1950, Ulam had conceived the idea of super compression, using the energy of a fission bomb to compress the fusion fuel to such a high density that it would be opaque to the radiation produced. Once Teller understood this, he invented a greatly improved, new method of compression using radiation, which then became the heart of the Ulam-Teller bomb design, which was tested, also in the South Pacific, on November 1, 1952. The Russians have freely acknowledged that Fuchs gave them the fission bomb, but they have insisted that no one gave them the fusion bomb, which grew out of design involving a fission bomb surrounded by alternating layers of fusion and fission fuels, and which they tested on November 22, 1955. Part of the irony of this story is that neither the American nor the Russian hydrogen-bomb programs made any use of the brilliant design that von Neumann and Fuchs had conceived as early as 1946, which could have changed the entire course of development of both programs.

Bernstein, Jeremy

2010-03-01

449

Is the von Kármán constant affected by sediment suspension?  

NASA Astrophysics Data System (ADS)

Is the von Kármán constant affected by sediment suspension? The presence of suspended sediment in channels and fluvial streams has been known for decades to affect turbulence transfer mechanism in sediment-laden flows, and, therefore, the transport and fate of sediments that determine the bathymetry of natural water courses. This study explores the density stratification effects on the turbulent velocity profile and its impact on the transport of sediment. There is as yet no consensus in the scientific community on the effect of sediment suspension on the von Kármán parameter,?. Two different theories based on the empirical log-wake velocity profile are currently under debate: One supports a universal value of? = 0.41 and a strength of the wake, ?, that is affected by suspended sediment. The other suggests that both ? and ? could vary with suspended sediment. These different theories result in a conceptual problem regarding the effect of suspended sediment on ?, which has divided the research area. In this study, a new mixing length theory is proposed to describe theoretically the turbulent velocity profile. The analytical approach provides added insight defining ?as a turbulent parameter which varies with the distance to the bed in sediment-laden flows. The theory is compared with previous experimental data and simulations using ak-?turbulence closure to the Reynolds averaged Navier Stokes equations model. The mixing length model indicates that the two contradictory theories incorporate the stratified flow effect into a different component of the log-wake law. The results of this work show that the log-wake fit with a reduced? is the physically coherent approximation.

Castro-Orgaz, Oscar; GiráLdez, Juan V.; Mateos, Luciano; Dey, Subhasish

2012-12-01

450

Terminal platelet production is regulated by von Willebrand factor.  

PubMed

It is established that proplatelets are formed from mature megakaryocytes (MK) as intermediates before platelet production. Recently, the presence of proplatelets was described in blood incubated in static conditions. We have previously demonstrated that platelet and proplatelet formation is upregulated by MK exposure to high shear rates (1800 s(-1)) on immobilized von Willebrand factor (VWF). The purpose of the present study was to investigate whether VWF is involved in the regulation of terminal platelet production in blood. To this end, Vwf (-/-) mice, a model of severe von Willebrand disease, were used to create a situation in which blood cells circulate in a vascular tree that is completely devoid of VWF. Murine platelets were isolated from Vwf (-/-) and Vwf (+/+) blood, exposed to VWF at 1800 s(-1) in a microfluidic platform, and examined by means of videomicroscopy, as well as fluorescence and activation studies. Proplatelets became visible within 5 minutes, representing 38% of all platelets after 12 minutes and 46% after 28 min. The proportion of proplatelets was 1.8-fold higher in blood from Vwf(-/-) mice than from Vwf(+/+) mice, suggesting a role of VWF in vivo. Fragmentation of these proplatelets into smaller discoid platelets was also observed in real-time. Platelets remained fully activatable by thrombin. Compensation of plasmatic VWF following hydrodynamic gene transfer in Vwf(-/-) mice reduced the percentage of proplatelets to wild-type levels. A thrombocytopenic mouse model was studied in the flow system, 7 days after a single 5-FU injection. Compared to untreated mouse blood, a 2-fold increase in the percentage of proplatelets was detected following exposure to 1800 s(-1) on VWF of samples from mice treated with 5-FU. In conclusion, VWF and shear stress together appear to upregulate proplatelet reorganization and platelet formation. This suggests a new function for VWF in vivo as regulator of bloodstream thrombopoiesis. PMID:23737952

Poirault-Chassac, Sonia; Nguyen, Kim Anh; Pietrzyk, Audrey; Casari, Caterina; Veyradier, Agnes; Denis, Cecile V; Baruch, Dominique

2013-01-01

451

Dr. Wernher Von Braun leads a tour of the S-IC checkout area.  

NASA Technical Reports Server (NTRS)

Dr. Eberhard Rees, Charles Schultze, James Webb, Elmer Staats, Comptroller General of the United States, and Dr. Wernher Von Braun tour the S-IC checkout area in the Marshall Space Flight Center quality lab.

1999-01-01

452

Neue Meßmöglichkeiten mit einem zur Untersuchung von Kunststoff-Schmelzen geeigneten modifizierten Weissenberg-Rheogoniometer  

Microsoft Academic Search

Zusammenfassung Mit einem Servo-Antrieb werden die Meßmöglichkeiten des bereits vorbeschriebenen, zur Messung von Kunststoff-Schmelzen modifiziertenWeissenberg-Rheogoniometers erweitert: Zu dem bislang ausschließlich ausgeführten Spannversuch (zeitl. konst. Schergeschwindigkeit\\u000a

J. Meißner

1975-01-01

453

Statement of Andrew von Eschenbach, M.D. - February 22, 2002  

Cancer.gov

Statement of Andrew von Eschenbach, M.D. Director, National Cancer Institute National Institutes of Health U.S. Department of Health and Human Services Before the United States Senate Committee on Appropriations Subcommittee on Labor, Health and

454

Der vollständige Brief Brahes an Sørensen über das Erscheinen des Kometen von 1577  

NASA Astrophysics Data System (ADS)

Es ist erstaunlich, daß sowohl Friis als auch Dreyer in ihrer Ausgabe der Briefe Tycho Brahes den Brief vom 14. November 1577 an Peter Sørensen, die erste bekannte Nachricht Brahes von seiner Entdeckung des Kometen von 1577, nur unvollständig, und zwar ohne den astronomischen Inhalt, ediert haben. Der Brief, dessen Original sehr wahrscheinlich nicht mehr existiert, wurde von dem Kieler Arzt und Medizinprofessor Johann Daniel Major (1634 - 1693) in Kopenhagen in sein Reisetagebuch kopiert. Das Original des Majorschen Reisetagebuches ist verschollen, doch es existieren zwei Abschriften davon (Kopenhagen, Königl. Bibl., Ny Kgl. Sml., 365, Fol. u. Ledreborg, 410, Fol.). Im folgenden wird nach einer kurzen Beschreibung des Stellenwerts, den der Komet von 1577 für Brahe besaß, der Brief nach diesen beiden Abschriften kritisch ediert, mit einer deutschen Übersetzung versehen und kurz kommentiert.

Kirschner, Stefan

455

Wilhelm Julius Foerster und die "Vereinigung von Freunden der Astronomie und kosmischen Physik" (1891 bis 1914).  

NASA Astrophysics Data System (ADS)

Am 19. Mai 1891 wurde ins Leben gerufen die "Vereinigung von Freunden der Astronomie und der kosmischen Physik (nachfolg.: V.A.P.) - eine der beiden institutionellen Vorläufer der sich 1953 konstituierenden "Vereinigung der Sternfreunde".

Tiemann, K.-H.

456

On stability properties of positive contractions of $L^1$-spaces accosiated with finite von Neumann algebras  

Microsoft Academic Search

In the paper we extent the notion of Dobrushin coefficient of ergodicity for positive contractions defined on $L^1$-space associated with finite von Neumann algebra, and in terms of this coefficient we prove stability results for $L^1$-contractions.

Farrukh Mukhamedov; Hasan Akin; Seyit Temir

2005-01-01

457

Untersuchungen über die Phagocytosebereitschaft der Leukocyten von an interstitieller Pneumonie erkrankten Säuglingen  

Microsoft Academic Search

Verfasser haben im Blutserum von Säuglingen mit interstitieller Pneumonie (i. P.) den Gehalt an Gesamteiweiß und den einzelnen Eiweißfraktionen bestimmt und das Phagocytosevermögen der Leukocyten bzw. die diesbezüglichen Zusammenhange untersucht. Als zu phagocytierende Bakterien dienten Staphylococcus albus-Suspensionen.

Gy. Ivady; E. Dux; Maria Illyés

1961-01-01

458

Fehler begehen - Mathematik verstehen Über die Bedeutung von Fehlern für das Verstehen  

NASA Astrophysics Data System (ADS)

Auch wenn eine historisch oder systematisch umfassende Darstellung zur Fehlerthematik bislang nicht vorliegt, ist die Idee, einer Fehleranalyse unter der Leitfrage, welche Fehler von Schülerinnen und Schülern aufgrund welcher epistemologischen Überzeugungen begangen werden, zentralen Raum für die Betrachtung von Verstehensprozessen einzuräumen, nicht neu. So ist es geradezu ein Charakteristikum einer modernen konstruktivistischen Didaktik, die eigenen Fehler von Lernenden als ihre individuellen Lerngelegenheiten zu begreifen, die einen wichtigen Motor für den subjektiven Lernfortschritt bilden. Diese Sichtweise wurzelt aus psychologischer Perspektive in Analysen in der Tradition Piagets, der in Abkehr von einer quantitativen, psychometrischen Beschreibung kognitiver Prozesse, wie sie sich zum Beispiel in Intelligenztheorien nach Binet findet, qualitativ zu beschreiben versuchte, in welcher Weise Kinder und Jugendliche denken und urteilen. Doch auch schon in der klassischen Philosophie sind entsprechende Ansätze zu finden. Prominente Beispiele hierfür sind die Idolenlehre Bacons und die Ideenlehre Platons.

Käser, Udo

459

Dr. Rees and Dr. von Braun at MSFC's Tenth Arniversary Picnic  

NASA Technical Reports Server (NTRS)

Marshall Space Flight Center (MSFC) Director Dr. Eberhard Rees conversing with former Center Director, Dr. Wernher von Braun, who along with his wife and son, participated in MFSC's Tenth Anniversary Celebration Picnic held at the Center's picnic area.

1970-01-01

460

APOLLO 14 DR. WERNHER VON BRAUN WATCHES FROM FIRING ROOM 2  

NASA Technical Reports Server (NTRS)

Dr. Wernher von Braun, the NASA Deputy Associate Administrator for Future Programs, uses binoculars to monitor data on closed- circuit television screens in Firing Room 2 of the Launch Control Center during final Apollo 14 launch preparations today.

1971-01-01

461

Die Wirkung von Adrenalin auf die Aktivität der Nierennerven beim Frosch  

Microsoft Academic Search

An Fröschen in Hydroxydion-Narkose wurde die Wirkung von intraarteriellen Adrenalininjektionen auf die Nierennerven untersucht. Die Versuche ergaben im einzelnen:1.Adrenalin hemmt die Aktivität der Nierennerven. Dauer und Ausmaß der Hemmung ist dosisabhängig. Die Schwellendosis liegt in der Größenordnung von 0,01 µg pro Versuchstier, entsprechend etwa 0,25 µg\\/kg.2.Die Hemmung der Nierennerven nach Adrenalin beruht erstens auf einer Erregung sensibler Endorgane im Gebiet

Eberhard Dieter

1961-01-01

462

Philosophie als Einübung des Perspektivenwechsels am Beispiel von Platon und Nietzsche  

Microsoft Academic Search

Zusammenfassung  In professioneller Beratung soll ein Perspektivenwechsel dazu dienen, bei ausweglos erscheinenden Situationen neue Denk- und\\u000a Handlungsmöglichkeiten zu erarbeiten. Die Philosophie bietet dazu vielfältige Konzepte und auch Prozessmodelle der Veränderung,\\u000a die für Berater eine reiche Ressource darstellen können. Der Autor beschreibt anhand von Platons „Höhlengleichnis“ und von\\u000a Nietzsches „Umwertung aller Werte“ eine Struktur der „Umwendung“, die jeweils in drei Stufen dargestellt

Christoph J. Schmidt-Lellek

2004-01-01

463

Zur Wirkung von emotional und sachlich gestalteten Audio-Guides in Museen  

Microsoft Academic Search

Marketing findet zunehmend auch bei Kulturinstitutionen Beachtung, was sich auch in zahlreichen wissenschaftlichen Beiträgen\\u000a widerspiegelt.1 In dem vorliegenden Beitrag wird die Wirkung von Audio-Guides analysiert, die bekanntermaßen inzwischen von vielen Museen\\u000a eingesetzt werden. Im Hinblick auf den Informationsbedarf eines Ausstellungsplaners wird gefragt, an welchen Größen die Wirkung\\u000a solcher Guides zu beurteilen ist. Sind sie nur ein Kosten- bzw. Erlösfaktor, oder

Carola Teffé; Lothar Müller-Hagedorn

464

Dynamic Force Spectroscopy of Glycoprotein Ib-IX and von Willebrand Factor  

Microsoft Academic Search

The first stage in hemostasis is the binding of the platelet membrane receptor glycoprotein (GP) Ib-IX complex to the A1 domain of von Willebrand factor in the subendothelium. A bleeding disorder associated with this interaction is platelet-type von Willebrand disease, which results from gain-of-function (GOF) mutations in amino acid residues 233 or 239 of the GP Ib? subunit of GP

Maneesh Arya; Anatoly B. Kolomeisky; Gabriel M. Romo; Miguel A. Cruz; José A. López; Bahman Anvari

2005-01-01

465

Das Gynözeum der Bignoniaceen I. Über den Bau des Fruchtknotens von Kigelia (Crescentieae)  

Microsoft Academic Search

Zusammenfassung Neben einer Beschreibung des Fruchtknotenbaues und der Anordnung der Bündel in der Scheidewand vonKigelia pinnata, africana, madagascariensis undaethiopum wird vor allem auf die unrichtige Wiedergabe des inneren Baues des Fruchtknotens in der Literatur hingewiesen. Der völlig zweifächerigeKigelia-Fruchtknoten wird nämlich von den meisten Systematikern (Seemann, Bentham etHooker, Baillon, Schumann, Sprague, Wood, Thonner, Van Steenis, Hutchinson andDalziel, Marloth, Bailey, Phillips, Andrews,

Walter Leinfellner

1972-01-01

466

Problemlösungszyklen im Rahmen von Lean Six Sigma: Vom Standard-DMAIC zum Blitz-DMAIC  

Microsoft Academic Search

In diesem Beitrag wird ein Überblick über die wesentlichen Problemlösungszyklen gegeben, welche im Rahmen von Lean Six Sigma\\u000a zum Einsatz kommen. Nach einer kurzen Vorstellung des PDCA-Zyklus, welcher als grundlegender Problemlösungszyklus im Qualitätsmanagement(QM)-Bereich\\u000a angesehen wird, folgt im Weiteren eine Darstellung des DMAIC-Zyklus. Dieser hat sich in vielen Six Sigma-Unternehmen bei der\\u000a Verbesserung von Prozessen bewährt und gilt heute als \\

Swen Günther; Bernd Garzinsky

467

Der Reaktionsmechanismus bei der Darstellung von Bariumhexaborid aus den Elementen unter Wasserstoff  

Microsoft Academic Search

Bei der Reaktion von Bariummetall mit elementarem Bor bildet sich in Gegenwart von Wasserstoff zunächst Bariumhydrid (BaH2). Im zweiten Reaktionsschritt diffundiert Bor in BaH2 ein, wobei die Umsetzung zu Bariumhexaborid (BaB6) durch die a-ß-Umwandlung des BaH2 begünstigt wird. Im Gegensatz zu Lanthanhexaborid zeichnet sich BaB6 durch einen weiten Homogenitätsbereich aus.

K. Torkar; H. Krischner; E. Hitsch

1971-01-01

468

Untersuchungen zur Bekämpfung von Beifußblättriger Ambrosie ( Ambrosia artemisiifolia ??L.) mit herbiziden Wirkstoffen  

Microsoft Academic Search

Zusammenfassung  Die Maßnahmen zur Kontrolle von A.??artemisiifolia müssen dem Ausmaß des standortspezifischen Befalls angepasst werden. In Brandenburg und Sachsen wurden zahlreiche Fundorte\\u000a von A.??artemisiifolia mit geringer Individuenzahl gemeldet. Für diese Standorte sind Eradikationsmaßnahmen vorgesehen und auch realisierbar. Weiterhin\\u000a gibt es speziell in Brandenburg Flächen, auf denen A.??artemisiifolia mit hohen Abundanzen vorkommt. Auf diesen Standorten geht es um eine Begrenzung der weiteren

Gerhard Schröder; Ewa Meinlschmidt

2009-01-01

469

Otmar von Verschuer collects fingerprints, still imageSite: DNA Interactive (www.dnai.org)  

NSDL National Science Digital Library

DNAi location: Chronicle>In the Third Reich>applying the solutionIn November 1942, Otmar von Verschuer succeeded Eugen Fischer as Director of the Kaiser Wilhelm Institute of Anthropology, Human Genetics, and Eugenics. von Verschuer had been the Director of the Institute of Hereditary Biology and Race Biology at the University of Frankfurt, where he had become famous for his studies of genetic vs. environmental influences in twins. His assistant at the University of Frankfurt was Josef Mengele.

2008-10-06

470

Otmar von Verschuer examines twin boys, still imageSite: DNA Interactive (www.dnai.org)  

NSDL National Science Digital Library

DNAi location: Chronicle>In the Third Reich>applying the solutionIn November 1942, Otmar von Verschuer succeeded Eugen Fischer as Director of the Kaiser Wilhelm Institute of Anthropology, Human Genetics, and Eugenics. von Verschuer had been the Director of the Institute of Hereditary Biology and Race Biology at the University of Frankfurt, where he had become famous for his studies of genetic vs. environmental influences in twins. His assistant at the University of Frankfurt was Josef Mengele.

2008-10-06

471

Plasma Product Treatment in Various Types of von Willebrand’s Disease  

Microsoft Academic Search

Four different virus-inactivated factor VIII concentrates (Haemate P, Behring; Profilate, Alpha, FVIII-VHP-vWF, CRTS), near-pure von Willebrand factor (Facteur Willebrand, CRTS) or one recombinant FVIII preparation (Recombinate, Baxter) were given to one or more patients with different forms of von Willebrand’s disease. Duke bleeding time, VIII:C, vWF:Ag, RCof activity, and the multimeric pattern of plasma vWF were monitored. Both Duke bleeding

Erik Berntorp

1994-01-01

472

Beitrag zur Ermittlung der Elastischen Energie von Punktdefekten, Einschlüssen und Entmischungsbezirken an Festkörperoberflächen  

Microsoft Academic Search

Zusammenfassung  Die vorliegende Arbeit beschäftigt sich mit der Berechnung der elastischen Energie von Volumendefekten im unmittelbaren Oberflächenbereich\\u000a von Festkörpern. Dabei gelingt es in Verallgemeinerung bisheriger Arbeiten für isotrope Medien sowohl einen analytischen Ausdruck\\u000a für die Wechselwirkungsenergie eines Defektes mit der Festkörperoberfläche als auch für die Wechselwirkung zweier Defekte\\u000a untereinander abzuleiten. Die erhaltenen Berechnungsformeln sind für beliebige Form und Lage der Defekte

B. Michel; HOCHSCHULE KARL-MARX-STADT

1978-01-01

473

Friedrich von Wieser and Friedrich A. Hayek: The General Equilibrium Tradition in Austrian Economics  

Microsoft Academic Search

Bruce Caldwell has disputed a number of points in my earlier account of the development of the Austrian school of economics from Carl Menger to Ludwig von Mises and F.A. Hayek. The issues in contention regard Friedrich von Wieser’s intellectual affiliation with Hayek and his influence on the formation of Hayek’s economic thought; Wieser’s status as a general equilibrium theorist;

Joseph T. Salerno

2002-01-01

474

Acquired von Willebrand’s Disease in Association with Essential Thrombocythemia: Regression following Treatment  

Microsoft Academic Search

Acquired von Willebrand’s disease in a 40-year-old woman affected with essential thrombocythemia (ET) is reported. The profile of plasma von Willebrand factor (vWF) revealed decreased ristocetin cofactor activity and diminished large multimers of vWF in spite of a normal vWF antigen level. There was no evidence of circulating inhibitor against the factor VIII complex. The vWF abnormality improved by controlling

Masahiro Murakawa; Takashi Okamura; Kumi Tsutsumi; Satoru Tanoguchi; Takumi Kamura; Tsunefumi Shibuya; Mine Harada; Yoshiyuki Niho

1992-01-01

475

Evaluation of a Rapid Automated Assay for Analysis of von Willebrand Ristocetin Cofactor Activity  

Microsoft Academic Search

A commercially available turbidometric assay has been evaluated for the measurement of von Willebrand factor ristocetin cofactor activity (VWF:RCo). The assay is simple, rapid, and can be cost-effectively performed on automated coagulation analyzers. This study’s aim is to illustrate the performance of the automated VWF:RCo assay and its capacity to identify patients with von Willebrand disease (VWD). By direct comparison

Karin Strandberg; Stefan Lethagen; Kerstin Andersson; Margareta Carlson; Andreas Hillarp

2006-01-01

476

DDAVP treatment in a child with von Willebrand disease type 2M  

Microsoft Academic Search

von Willebrand disease (vWD) type 2M is characterized by the decreased platelet-dependent function of the von Willebrand factor (vWF) that is not caused by the absence of HMW vWF multimers. We report here on a 4-year-old boy with vWD type 2M, who underwent adenotomy and paracentesis after correction of his hemostatic defect by stimulation with DDAVP. The decreased basal levels

C. Mauz-Körholz; U. Budde; D. Körholz; U. Göbel

1999-01-01

477

Laboratory Diagnosis and Molecular Basis of Mild von Willebrand Disease Type 1  

Microsoft Academic Search

Mild type 1 von Willebrand disease (VWD) is characterized by low to variable penetrance of bleeding, a high (increased) prevalence of blood group O, von Willebrand factor (VWF) values around and above 30% with normal ratios of VWF:ristocetin cofactor activity (RCo)\\/VWF:antigen (Ag), VWF:collagen binding (CB)\\/VWF:Ag and factor VIII (FVIII):coagulant activity (C)\\/VWF:Ag. Within this group of patients, the combination of the

Jan Jacques Michiels; Zwi Berneman; Alain Gadisseur; Marc van der Planken; Wilfried Schroyens; Huub H. D. M. van Vliet

2009-01-01

478

Multimeric analysis of von Willebrand factor by molecular sieving electrophoresis in sodium dodecyl sulphate agarose gel.  

PubMed

We report the development and optimisation of an agarose gel electrophoretic method for the separation and detection of von Willebrand Factor (vWF) multimers. The method has been specifically developed for use in the clinical evaluation and classification of patients with von Willebrand's Disease (vWD) and clearly shows structural multimer abnormalities associated with the bleeding diathesis of this inherited bleeding disorder. PMID:2084949

Raines, G; Aumann, H; Sykes, S; Street, A

1990-11-01

479

Protektive Stentimplantation nach erfolgreicher Rekanalisation von chronischen Koronarverschlüssen: Eine Matched-Pair-Analyse in 100 Patienten  

Microsoft Academic Search

Zusammenfassung Ziel der Studie: Das Ergebnis einer erfolgreichen Ballondilatation von chronischen Koronarverschlüssen ist wegen der hohen Restenose- und Reokklusionsrate nicht zufriedenstellend. Diese kontrollierte Studie untersucht, ob die protektive Implantation eines Stents die Langzeitergebnisse nach Rekanalisation verbessern kann. Methoden: Um den Nutzen der protektiven Stentimplantation von chronischen Koronarverschlüssen zu untersuchen, wurden 100 Patienten in einer Matched-Pair-Analyse (Block-Design) verglichen. Bei 50 Patienten

S. Fratz; T. Meinertz; C. A. Nienaber

1998-01-01

480

Zur Anatomie des Holzes von Microcycas calocoma (Miq.) A. DC. unter besonderer Berücksichtigung der Faserelemente  

Microsoft Academic Search

Zusammenfassung Microcycas calocoma läßt sich vonCycas circinalis undC. revoluta holzanatomisch gut abgrenzen. Die anatomischen Eigenschaften des Holzes vonMicrocycas können in drei Gruppen eingeteilt werden: (1) in Merkmale, die in allen Stammteilen etwa gleich sind, (2) in Merkmale, die in den verschiedenen Stammteilen unterschiedlich ausgebildet sein können, jedoch keine Beziehungen zur Lage im Stamm zeigen und (3) in Merkmale, die sich

H. Süss; W. R. Müller-Stoll

1970-01-01

481

‚Armee der Einheit‘: Zur Integration von NVA-Soldaten in die Bundeswehr  

Microsoft Academic Search

\\u000a Das staatliche Gewaltmonopol in der DDR war von Anfang nicht nur dem Militär vorbehalten, sondern verteilte sich auf unterschiedliche\\u000a Kräfte (vgl. Wenzke 1994; Died-rich\\/Ehlert\\/Wenzke 1998). Gleichwohl stellte die Nationale Volksarmee (NVA) ohne Zweifel das\\u000a größte und bedeutendste Element der Landesverteidigung der DDR dar. Laut Verfassung der DDR von 1968 hatte die NVA den Auftrag,\\u000a „die sozialistischen Errungenschaften des Volkes gegen

Nina Leonhard

482

(Never) Mind your p's and q's: Von Neumann versus Jordan on the foundations of quantum theory  

NASA Astrophysics Data System (ADS)

In 1927, in two papers entitled "On a new foundation [Neue Begründung] of quantum mechanics," Pascual Jordan presented his version of what came to be known as the Dirac-Jordan statistical transformation theory. Jordan and Paul Dirac arrived at essentially the same theory independently of one another at around the same time. Later in 1927, partly in response to Jordan and Dirac and avoiding the mathematical difficulties facing their approach, John von Neumann developed the modern Hilbert space formalism of quantum mechanics. We focus on Jordan and von Neumann. Central to the formalisms of both are expressions for conditional probabilities of finding some value for one quantity given the value of another. Beyond that Jordan and von Neumann had very different views about the appropriate formulation of problems in quantum mechanics. For Jordan, unable to let go of the analogy to classical mechanics, the solution of such problems required the identification of sets of canonically conjugate variables, i.e., p's and q's. For von Neumann, not constrained by the analogy to classical mechanics, it required only the identification of a maximal set of commuting operators with simultaneous eigenstates. He had no need for p's and q's. Jordan and von Neumann also stated the characteristic new rules for probabilities in quantum mechanics somewhat differently. Jordan and Dirac were the first to state those rules in full generality. Von Neumann rephrased them and, in a paper published a few months later, sought to derive them from more basic considerations. In this paper we reconstruct the central arguments of these 1927 papers by Jordan and von Neumann and of a paper on Jordan's approach by Hilbert, von Neumann, and Nordheim. We highlight those elements in these papers that bring out the gradual loosening of the ties between the new quantum formalism and classical mechanics. This paper was written as part of a joint project in the history of quantum physics of the Max Planck Institut für Wissenschaftsgeschichte and the Fritz-Haber-Institut in Berlin.

Duncan, A.; Janssen, M.

2013-03-01

483

Tracial gauge norms on finite von Neumann algebras satisfying the weak Dixmier property  

Microsoft Academic Search

In this paper we set up a representation theorem for tracial gauge norms on finite von Neumann algebras satisfying the weak Dixmier property in terms of Ky Fan norms. Examples of tracial gauge norms on finite von Neumann algebras satisfying the weak Dixmier property include unitarily invariant norms on finite factors (type ${\\\\rm II}\\\\sb 1$ factors and $M_n(\\\\cc)$) and symmetric

Junsheng Fang; Don Hadwin; Eric Nordgren; Junhao Shen

2007-01-01

484

Bereitstelhmg von Dienstgüte für aggregierte Multimedia-Ströme in lokalen 'Broadcast'-Netzen  

Microsoft Academic Search

Mit der zunehmenden Bedeutung von echtzeitkritischen Audio- und Videoapplikationen wächst die Wichtigkeit von Dienstgütegarantien\\u000a in Rechnernetzen. Als eine Möglichkeit Dienstgüte zu gewährleisten, bietet sich die Ressourcenreservierung, wobei sich eine\\u000a statische Reservierung als ineffizient herausgestellt hat. In der vorgestellten Arbeit wurde ein dynamisches Reservierungssystem\\u000a auf seine Eignung für aggregierte Audio- und Videolasten untersucht. Durch analytische Untersuchungen konnte zunächst gezeigt\\u000a werden, dass

Stephan Heckmtiller

2007-01-01

485

Versuche zur Gewinnung von katalytischen Antikörpern zur Hydrolyse von Arylcarbamaten und Arylharnstoffen. (English Title: Attempts to produce catalytic antibodies for hydrolysis of arylcarbamates and arylureas)  

NASA Astrophysics Data System (ADS)

Im Rahmen dieser Arbeit gelang es, katalytische Antikörper zur Hydrolyse von Benzylphenylcarbamaten sowie zahlreiche monoklonale Antikörper gegen Haptene herzustellen. Es wurden verschiedene Hapten-Protein-Konjugate unter Verwendung unterschiedlicher Kopplungsmethoden hergestellt und charakterisiert. Zur Generierung der hydrolytisch aktiven Antikörper wurden Inzuchtmäuse mit KLH-Konjugaten von 4 Übergangszustandsanaloga (ÜZA) immunisiert. Mit Hilfe der Hybridomtechnik wurden verschiedene monoklonale Antikörper gegen diese ÜZA gewonnen. Dabei wurden sowohl verschiedene Immunisierungsschemata als auch verschiedene Inzuchtmausstämme und Fusionstechniken verwendet. Insgesamt wurden 32 monoklonale Antikörper gegen die verwendeten ÜZA selektiert. Diese Antikörper wurden in groen Mengen hergestellt und gereinigt. Zum Nachweis der Antikörper-vermittelten Katalyse wurden verschiedene Methoden entwickelt und eingesetzt, darunter immunologische Nachweismethoden mit Anti-Substrat- und Anti-Produkt-Antikörpern und eine photometrische Methode mit Dimethylaminozimtaldehyd. Der Nachweis der hydrolytischen Aktivität gelang mit Hilfe eines Enzymsensors, basierend auf immobilisierter Tyrosinase. Die Antikörper N1-BC1-D11, N1-FA7-C4, N1-FA7-D12 und R3-LG2-F9 hydrolysierten die Benzylphenylcarbamate POCc18, POCc19 und Substanz 27. Der Nachweis der hydrolytischen Aktivität dieser Antikörper gelang auch mit Hilfe der HPLC. Der katalytische Antikörper N1-BC1-D11 wurde kinetisch und thermodynamisch untersucht. Es wurde eine Michaelis-Menten-Kinetik mit Km von 210 µM, vmax von 3 mM/min und kcat von 222 min-1 beobachtet. Diese Werte korrelieren mit den Werten der wenigen bekannten Diphenylcarbamat-spaltenden Abzyme. Die Beschleunigungsrate des Antikörpers N1-BC1-D11 betrug 10. Das ÜZA Hei3 hemmte die hydrolytische Aktivität. Dies beweist, dass die Hydrolyse in der Antigenbindungsstelle stattfindet. Weiter wurde zwischen der Antikörperkonzentration und der Umsatzgeschwindigkeit eine lineare Abhängigkeit festgestellt. Die thermodynamische Gleichtgewichtsdissoziationskonstante KD des Abzyms von 2,6 nM zeugt von einer sehr guten Affinität zum ÜZA. Hydrolytisch aktiv waren nur Antikörper, die gegen das Übergangszustandsanalogon Hei3 hergestellt worden waren. Es wird vermutet, dass die Hydrolyse der Benzylphenylcarbamate über einen Additions-Eliminierungsmechanismus unter Ausbildung eines tetraedrischen Übergangszustandes verläuft, dessen analoge Verbindung Hei3 ist. Im Rahmen der Generierung von Nachweisantikörpern zur Detektion der Substratabnahme bei der Hydrolyse wurden Anti-Diuron-Antikörper hergestellt. Einer der Antikörper (B91-CG5) ist spezifisch für das Herbizid Diuron und hat einen IC50-Wert von 0,19 µg/l und eine untere Nachweisgrenze von 0,04 µg/l. Ein anderer Antikörper (B91-KF5) reagiert kreuz mit einer Palette ähnlicher Herbizide. Mit diesen Antikörpern wurde ein empfindlicher Labortest, der ein Monitoring von Diuron auf Grundlage des durch die Trinkwasserverordnung festgeschriebenen Wertes für Pflanzenschutzmittel von 0,1 µg/l erlaubt, aufgebaut. Der Effekt der Anti-Diuron-Antikörper auf die Diuron-inhibierte Photosynthese wurde in vitro und in vivo untersucht. Es wurde nachgewiesen, dass sowohl in isolierten Thylakoiden, als auch in intakten Algen eine Vorinkubation der Anti-Diuron-Antikörper mit Diuron zur Inaktivierung seiner Photosynthese-hemmenden Wirkung führt. Wurde der Elektronentransport in den isolierten Thylakoiden oder in Algen durch Diuron unterbrochen, so führte die Zugabe der Anti-Diuron-Antikörper zur Reaktivierung der Elektronenübertragung. Attempts to produce catalytic antibodies for hydrolysis of arylcarbamates and arylureas: The aim of the investigations was to produce antibodies which are able to cleave herbicides resistant to naturally occuring enzymes. Structurally similar carbamate and urea derivatives were chosen for the experiments. Phosphonate derivatives were synthesized that mimick possible transition state analogues in structure and charge. Mice were immunized

Werner, Deljana

2002-05-01

486

Vergleichende Untersuchungen mit Hilfe von Munsell-Farbtafeln und des CIELAB-Farbsystems zur Winterchlorose von Pinus sylvestris L. im Immissionsgebiet Dübener Heide  

Microsoft Academic Search

Zusammenfassung  Mit dem Farbmeßsystem Pretema 4005 erfolgt an 8 cm2 großen, mit 2–4 mm langen Nadelstücken bedeckten Flächen die Messung der Reflexionsspektren von Kiefernnadeln im sichtbaren\\u000a Wellenlängenbereich. Die anschließende Berechnung der Farborte im CIELAB-Farbraum ermöglicht die Erfassung von Farbunterschieden\\u000a zwischen zwei Proben als räumlichen Abstand dieser Farborte. Die Gesamtfarbdifferenz wird in einen Helligkeits(lightness)-,\\u000a Brillanz(chroma)- und Farbton(hue)-Beitrag zerlegt, womit die Vergleichbarkeit zur

G. Baronius; H. J. Fiedler; H. G. Montag

1991-01-01

487

Definition and Quantitation in Ecology  

Microsoft Academic Search

AUSTIN1, in commenting on my communication2, has provided an example of the problems which arise in justifying a non-quantitative approach to a subject such as ecology. Austin attaches significance to an imprecision of definition in my examination of the relationships among functional properties of Californian grasslands, and concludes ``more adequate definitions are necessary before McNaughton's suggestions ... can profitably be

S. J. McNaughton

1968-01-01

488

Validity in quantitative content analysis  

Microsoft Academic Search

Over the past 15 years, educational technologists have been dabbling with a research technique known as quantitative content\\u000a analysis (QCA). Although it is characterized as a systematic and objective procedure for describing communication, readers\\u000a find insufficient evidence of either quality in published reports. In this paper, it is argued that QCA should be conceived\\u000a of as a form of testing

Liam Rourke; Terry Anderson

2004-01-01

489

Quantitative Modeling of Sleep Dynamics  

Microsoft Academic Search

\\u000a Arousal state is largely controlled by the ascending arousal system of the brainstem, which projects to the corticothalamic\\u000a system that produces the electroencephalographic signatures of sleep that are commonly observed. Quantitative modeling of\\u000a corticothalamic and brainstem dynamics via neural field theory is described here, using physiologically realistic models and\\u000a parameters. It is shown that both cortex and thalamus must be

P. A. Robinson; A. J. K. Phillips; B. D. Fulcher; M. Puckeridge; J. A. Roberts; C. J. Rennie

490

Quantitative modelling of sleep dynamics.  

PubMed

Arousal is largely controlled by the ascending arousal system of the hypothalamus and brainstem, which projects to the corticothalamic system responsible for electroencephalographic (EEG) signatures of sleep. Quantitative physiologically based modelling of brainstem dynamics theory is described here, using realistic parameters, and links to EEG are outlined. Verification against a wide range of experimental data is described, including arousal dynamics under normal conditions, sleep deprivation, stimuli, stimulants and jetlag, plus key features of wake and sleep EEGs. PMID:21893531

Robinson, P A; Phillips, A J K; Fulcher, B D; Puckeridge, M; Roberts, J A

2011-10-13

491

Quantitative 3D CT bronchography  

Microsoft Academic Search

In the framework of computer-aided diagnosis, this paper pro- poses a novel functionality for computerized tomography (CT)- based investigation of pulmonary airways. It provides a specific visualization modality - the virtual CT bronchography - together with quantitative investigation via a central axis-based description. This functionality relies on an energy-based 3D reconstruction of the bronchial tree up to the order divisions.

Catalin L. Fetita; Françoise J. Preteux

2002-01-01

492

Quantitative Comparison of Contour Maps  

Microsoft Academic Search

Maps can be quantitatively compared by using trend-surface analysis to simplify complex situations and then studying the components. Relationships of configuration of one map to another (geologic structure in this example) can easily be found by using the equation coefcients of well-fitted first-, second-, and third-degree trend surfaces to determine the similarity between any pair of maps, and cluster analysis

PETER H. A. SNEATH

1966-01-01

493