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1

Die quantitative Bestimmung von Borfluorwasserstoffsäure neben freier Borsäure mit Hilfe von Cetyl-trimethyl-ammonium-chlorid  

Microsoft Academic Search

Zusammenfassung  Im Cetyl-trimethyl-ammoniumchlorid wurde ein Reagens gefunden, welches die quantitative Bestimmung von Borfluorwasserstoffsäure neben Flußsäure und Borsäure gestattet.Durch Anwendung einer überschüssigen Cetyl-trimethyl-ammoniumchloridlösung von bestimmtem Gehalt gelingt es, HBF4 quantitativ als weißen kristallinen Niederschlag von der Zusammensetzung (C19H42N)·(BF4) abzuscheiden, einer Verbindung, die gegenüber dem bisher gebräuchlichen Nitronborfluorid eine mehr als 10mal geringere Löslichkeit (L20\\u000a0,0025) aufweist.Nach der Fällung wird ein gegebener, die

Heinz-Jürgen Schaack; Walter Wagner

1955-01-01

2

Grundlagen der Bestimmung von Enzymaktivitäten  

Microsoft Academic Search

Die optische Methode von Otto Warburg sowie andere physikalische Meßverfahren wie die Fluorimetrie, die Polarimetrie, die Titrimetrie bei stationäremph (ph-Stat) und andere Methoden werden heute bevorzugt zur Aktivitätsbestimmung von Enzymen herangezogen. Diese Verfahren, durch Anschluß registrierender Schreiber erleichtert, haben gegenüber den klassischen chemisch-analytischen Verfahren den Vorteil einer fortlaufenden Darstellung des Reaktionsablaufes und gestatten eine einfache Ablesung der Aktivität eines Enzyms

Benno Hess; Karl Brand

1964-01-01

3

Zur Bestimmung von Aminostickstoff in Getreidesirupen  

Microsoft Academic Search

[%er die Bestimmung der Fluorescenz in Spriten beriehtet O. WANGE~ ~. Im ersten Teil des Arbeit diskutiert Verf. die theoretischen Probleme nnd erli4utert den Einfiul~ versehiedener Fak~oren auf die for die Fluorescenzmessung als Vergleichstypen dienenden NatrinmsalicylatlSsungen. So wurden Untersuchungen angestellt fiber den Einflul~ der Aufbewahrung und der Herkunft des Natriumsalicylats sowie der Konzentration des Alkohols. Da mit abnehmender Alkoholkonzentration aueh

Doris Rittweger-Heiligmann

1964-01-01

4

Anreicherung und Bestimmung von Eisen in Nickel und Reinstnickelsalzen als Fe(SCN) 3 · 3 TBP  

Microsoft Academic Search

Zusammenfassung Es wird ein Verfahren zur extraktiven Anreicherung und gleichzeitigen Bestimmung kleiner Eisenmengen in Nickel und Reinstnickelsalzen unter Verwenden von Thiocyanat und Tri-n-butylphosphat mitgeteilt. Die auf der selektiven Extraktion und großen Farbintensität von Fe(SCN)3 · 3 TBP aufgebaute Methode gestattet die Bestimmung von Eisen in 10 g-Einwaagen bis hinunter zu 3 · 10?6% Fe. Die relative Standardabweichung ist kleiner als

Ewald Jackwerth

1964-01-01

5

Bestimmung von Titan(IV) durch Amperometrische Titration  

Microsoft Academic Search

Spektrophotometrisch wurde festgestellt, dab Titan(IV) mit KomenaminsS_ure (4,5-Dioxy-pyridin-2-carbonsfiure) Acetatpuffer eine gelbe und sehr stabile Komplexverbindung ergibt und dab das st6chiometrische Verh\\/iltnis zwischen Titan(IV) und KomenaminsS, ure 1:2 betr~igt [1]. In der vorliegenden Arbeit haben wir die polarographische Welle der Komenaminsfiure [2] sowie die Komplexbildung dieser Sfiure mit Titan(IV) ausgenutzt, um eine Methode zur amperometrischen Bestimmung yon Titan(IV) zu entwickeln. Die

Andjelija Djukanovi?-Stefanovi?; Branislava Stankovi?

1981-01-01

6

Beitrag zur kolorimetrischen bestimmung von sulfid-ionen  

Microsoft Academic Search

Zusammenfassung Nach einer kurzen Diskussion der Molybdänblau- und Methylenblaumethode sowie der überprüften Farbreaktion mit Ammoniummolybdat und Kaliumrhodanid werden weitere Versuche zur Kolorimetrie von Sulfidionen bzw. von Schwefelwasserstoff mitgeteilt. Das in einer früheren Mitteilung empfohlene Wismutreagens wurde nach eingehenden Versuchen geringfügig abgeändert. Es ist nunmehr etwa 3 Wochen haltbar. Die Analysenergebnisse sind befriedigend.

H. Koren; W. Gierlinger

1953-01-01

7

Die bestimmung des Schwefels im Sprit nach der Verbrennungsmethode  

Microsoft Academic Search

Zusammenfassung Die Lampen-Methode von American Society of Testing Materials (A. S. T. M.) zur Bestimmung des Schwefelgehaltes in Erdölprodukten wurde für die Bestimmung von kleinen im Sprit als Verunreinigung vorkommenden Schwefelmengen modifiziert. Für die Bestimmung wurde eine Apparatur entworfen und ausgeführt, in der der Sprit in einem entschwefelten Luftstrom verbrannt und der schwefelenthaltende Teil der Verbrennungsgase quantitativ absorbiert wird. Der

Risto J. Peltonen; P. Neuenschwander; Heikki Suomalainen

1955-01-01

8

Bestimmung der Netzhautdicke in Abhängigkeit von Alter und Achsenlänge mit Hilfe der optischen Kohärenztomographie  

Microsoft Academic Search

Zusammenfassung  \\u000a \\u000a Hintergrund. Es ist unbekannt, ob die Netzhautdicke von der Achsenlnge und\\/oder vom Alter abhngt. Wir haben deshalb in Augen ohne Netzhautvernderung\\u000a die Netzhautdicke mit Hilfe der optischen Kohrenztomographie (OCT) bestimmt und mit Achsenlnge und Alter korreliert.\\u000a \\u000a \\u000a \\u000a \\u000a Probanden. In die Studie wurden 205 Augen mit regelrechtem Makulabefund von 159 Probanden im Alter von 13–92 Jahren aufgenommen. Bei\\u000a jedem Probanden wurden

W. Göbel; F. Hartmann; W. Haigis

2001-01-01

9

Zur Bestimmung der Normalspannungs-Funktionen von Hochpolymeren mittels der Kegel-Platte-Abstand-Anordnung (KPA)  

Microsoft Academic Search

Zusammenfassung Im Rahmen dieser Arbeit wird die vonJackson undKaye vorgeschlagene Kegel-Platte-Abstand-Methode überarbeitet, mit der es möglich ist, aneiner Meßprobe ohne Systemwechsel unter Anwendung nureiner Kraft-Meßmethodebeide Normalspannungsfunktionen zu ermitteln.

R. Rautenbach; P. Schümmer; J. F. Petersen

1975-01-01

10

Über die Reproduzierbarkeit der turbidimetrischen Bestimmung von Phosphorspuren mit Strychninmolybdostickstoff(V)säure  

Microsoft Academic Search

Zusammenfassung Mit der turbidimetrischen Strychninnitrat-Methode für Phosphorspurenbestimmung nach der Version von Hegedüs und Dvorszky kann man nur dann ausgezeichnete Reproduzierbarkeit erreichen, wenn das für die Reagenszubereitung verwendete MoO3 0,2–0,5% WO3\\/MoO3 enthält. Falls weniger als 0,01% WO3\\/ MoO3 anwesend sind, kommt es zu starken Meßwertschwankungen.

A. J. Hegedüs; T. Bereznai; Klara Horkay; A. B. Kiss; Martha Lakó

1975-01-01

11

Gaschromatographische Bestimmung von Diacetyl, Acetoin und 2,3-Pentandion in Wein  

Microsoft Academic Search

Summary The determination of diacetyl, 2.3-pentanedione and acetoin was performed in two steps. Diacetyl and 2.3-pentanedione were driven off with gaseous nitrogen at 60° C and collected in ice cooled methanol. The quantitative gaschromatographical determination follows after directly injecting this solution into the gas chromatograph employing an electron capture detector which indicates selectively the vicinale diketones. In a second experiment

Wilhelm Postel; Ulgar Güvenc

1976-01-01

12

Quantitative In-situ-Fluorimetrie von Dinitrophenylaminosäuren auf Dünnschichtchromatogrammen  

Microsoft Academic Search

Zusammenfassung Die quantitative In-situ-Analyse von Dinitrophenyl-(DNP-)Aminosäuren mit Hilfe der Fluoreszenzlöschung auf Kieselgelschichten wird beschrieben. Die Dünnschichtchromatogramme mit den aufgetrennten DNP-Aminosäuren wurden mit einem Turner Fluorimeter, Modell 111, ausgerüstet mit einer Camag Dünnschichtchromatographie-Meßtür und einem 10-MV Heathkit Recorder, ausgewertet. Der Einfluß von Zeit,

J. Borko; R. W. Frei

1969-01-01

13

Die bestimmung des diacetyls im sprit  

Microsoft Academic Search

Zusammenfassung Die für die Bestimmung des Diacetylgehaltes im Sprit entwickelte Methode beruht auf der photometrischen Messung der in einer Pyridin-Äthylendiaminhydrat-lösung des bis-2,4-Dinitrophenylhydrazons des Diacetyls entstandenen violetten Färbung. Bis-2,4-Dinitrophenylhydrazon des Diacetyls wird von anderen Hydrazonen, wenigstens von dem Hydrazon des Acetaldehydes and dem bei den Reaktionsumständen sich bildenden Monohydrazon des Acetylmethylearbinols Bowie von dem überschüssigen Reagens auf Grund seiner Schwerlöslichkeit in

Tapio Salo; Heikki Suomalainen

1957-01-01

14

Extraction, quantitative gas chromatographic determination and gas chromatographic\\/mass spectrometric detection of ecgonine for identification of cocaine and its metabolites in urine  

Microsoft Academic Search

Es wurden quantitative Untersuchungen zur Extraktion von Urin durchgeführt, dem Cocain, Benzoylecgonin, Ecgoninmethylester und Ecgonin zugesetzt wurden. Die Summe dieser Verbindungen kann über eine vorgeschaltete Hydrolyse zu Ecgonin indirekt bestimmt werden. Nach Hydrolyse wird Ecgonin an einem Kationenaustauscher isoliert und der Extrakt an einem Anionenaustauscher gereinigt. Die quantitative Bestimmung erfolgt gaschromatographisch nach Silylierung mit MSTFA. Dabei beträgt die Wiederfindungsrate 77%

S. Goenechea; G. Rficker; M. Neugebauer; U. Zerell

1986-01-01

15

Reaktive Tracer zur Bestimmung der sedimentären Aquifer-Oxidationskapazität im Labor und Feldversuch  

Microsoft Academic Search

Kurzfassung Mikrobiell reduzierbares Eisen(III) im Aquifer kann als Elektronenakzeptor von großer Bedeutung für Natural Attenuation (NA) von aromatischen Kohlenwasserstoffen sein und bildet den Hauptbestandteil der sedimentären Oxidationskapazität (OXC) des Aquifers. Untersuchungsgegenstand war der Vergleich traditioneller, nasschemischer Methoden mit neuentwickelten, reaktiven Tracerverfahren zur Bestimmung der sedimentären OXC. Die innovativen Tracermethoden haben gegenüber nasschemischen Extraktionsverfahren den prinzipiellen Vorteil, dass sie einen integralen

Frank Dethlefsen; Fabian Bliss; Thorsten Wachter; Andreas Dahmke

2004-01-01

16

Zur Bestimmung komplexgebundener Solvensmolekeln an extrahierten anorganischen Verbindungen  

Microsoft Academic Search

Die analytischen Möglichkeiten zur Bestimmung der Solvensligandenzahl extrahierter anorganischer Verbindungen in organischen Lösungsmitteln nach dem Verfahren der kontinuierlichen Variation wird an einzelnen Beispielen erläutert. Aus den Maxima der Verteilungskurven ergeben sich bei der Kationen- und Anionenvariation nur dann gleiche und eindeutige Ergebnisse, wenn unabhängig von der Konzentration der einzelnen Lösungsparameter nur eine anorganische Verbindung extrahiert wird. Beispiele dafür sind Fe(SCN)3(TBP)3

Ewald Jackwerth; Hermann Specker

1960-01-01

17

Die Anreicherung und mikromaßanalytische Bestimmung des Strontiumions in Mineralwässern  

Microsoft Academic Search

Zusammenfassung Es wurde versucht, eine neue Methode der Anreicherung und mikroanalytischen Bestimmung des Strontiumions samt dessen Abtrennung vom Bariumion auszuarbeiten. Zur Anreicherung wurde die schwach alkalische Aluminiumoxyd-Säule verwendet, die unter Einhaltung der beschriebenen Versuchsbedingungen quantitativ alles Strontium und Barium zurückhält. Die Abtrennung von Calcium und den Alkalimetallen erfolgte mittels der Salpetersäure-Methode nachS. G. Rawson, die wir jedoch für die Mikroanalyse

H. Ballczo; H. Muthenthaller

1952-01-01

18

Beitrag zur kolorimetrischen Bestimmung von Sulfidionen  

Microsoft Academic Search

Zusammenfassung Die aus der Literatur bekannt gewordenen kolorimetrischen Methoden zur quantitativen Erfassung kleiner Mengen an Sulfidionen werden dahingehend untersucht, daß Absorptionskurven der gebildeten Farbstoffe bzw. Sulfidsole quantitativ vermessen werden. In den meisten Fällen erhält man so sowohl ein Maß für die Empfindlichkeit als auch Kenntnis des optimalen Wellenlängenbereiches für die Durchführung der kolorimetrischen Messung.

E. Treiber; H. Koren; W. Gierlinger

1952-01-01

19

Polarimetrie von Wolframkomplexen mit optisch aktiven Hydroxysäuren  

Microsoft Academic Search

An Hand der stark erhöhten Drehung von optisch aktiven Hydroxysäuren in Gegenwart von Natriumwolframat wird eine Eichkurve für die Abhängigkeit der optischen Aktivität von der Wolframkonzentration aufgestellt, die von analytischem Interesse für die Bestimmung dieses Metalls und der verwendeten Hydroxysäure sein könnte. Außerdem wird in anderen Kurven die Abhängigkeit der spezifischen Drehung vom molaren Quotienten Wolfram\\/l-Äpfelsäure und Wolfram\\/d-Weinsäure bei verschiedenen

Kurt Jacobsohn; Maria Deodata Azevedo

1964-01-01

20

Photometer mit Selen-Photoelement zur spektralen Messung der Sonnenstrahlung und zur Bestimmung der Wellenlängenabhängigkeit der Dunsttrübung  

Microsoft Academic Search

Zur laufenden Bestimmung der Dunsttrübung der Atmosphäre standen bisher fast nur Aktinometer zur Verfügung. Diese Geräte besitzen zur Messung der Sonnenstrahlung thermische Empfangselemente; um die Dunsttrübung und ihre Wellenlängenabhängigkeit genau zu erhalten und von der Absorption des Wasserdampfes zu trennen, sind Filtermessungen (Differenzmessungen) und zeitraubende Auswertungen nötig.

F. Volz

1959-01-01

21

Nebennieren-Funktionsdiagnostik im Kindesalter durch fluorometrische 11HydroxyCorticosteroid(11-OHCS)-Bestimmung im Harn nach i.v. Gabe synthetischer ACTH-Präparate  

Microsoft Academic Search

Zusammenfassung Es wird über eine verbesserte Technik der NNR-Funktionsdiagnostik berichtet, welche erlaubt, bei Säuglingen und Kindern im Harn von 8 Std nach i.v. Stimulation mit synthetischem ACTH mit bisher nicht erreichter Präzision und Einfachheit die kurzfristige Funktionsbereitschaft der NNR zu erfassen. Als biochemisches Kriterium wird eine vonDörner angegebene fluorometrische Methode der 11-Hydroxycorticoid-(Cortisol-)Bestimmung im Harn eingesetzt. Die Methode gestattet, neben der

D. Knorr; D. Messenzehl; O. Butenandt

1969-01-01

22

Bestimmung des Methanolgehaltes im Sprit mit Chromotropsäure  

Microsoft Academic Search

Zusammenfassung Die Eignung der Bremanis-Methode für die Bestimmung des Methanolgehaltes im Sprit wurde geklärt. Besondere Beachtung wurde geschenkt der Äthanolkonzentration, der Erhitzungstemperatur und -dauer, der Schwefelsäure- und Chromotropsäure-Konzentration, dem Alter der Chromotropsäurelösung sowie der Oxydationszeit und der Stabilität der Farbe der Reaktionslösung zwecks Erreichung optimaler Bedingungen.

Lauri Uino; Tapio Salo

1960-01-01

23

Zur Spurenanreicherung an Aktivkohle. Bestimmung von Elementspuren in Wolframpulver  

Microsoft Academic Search

A method is described for the enrichment of traces of Ag, Cd, Co, Cu, In, Ni, Pb, Tl, and Zn in powdered tungsten. For this purpose the elements are complexed with sodium diethyldithiocarbamidate (NaDDTC) after dissolving the sample in H2O2. By filtration of the sample solution through a filter paper coated with activated carbon the chelate compounds are adsorbed and

E. Jackwerth; J. Lohmar; G. Wittler

1974-01-01

24

Bestimmung von Dichlorpropanolen und Monochlorpropandiolen in Würzen und würzehaltigen Lebensmitteln  

Microsoft Academic Search

Summary A method is described for the determination of dichloropropanols (DCP) and monochloropropandiols (MCPD) in seasonings and in foodstuffs containing seasonings. After adsorption onto an Extrelut column DCP and MCPD are extracted using ethyl acetate. Due to a weak alkalisation, acid compounds remain in the water phase. The ethyl acetate extract is concentrated and DCP and MCPD are determined by

Roland Wittmann

1991-01-01

25

Quantitative Aktivitätsbestimmung von Enzymen des Kohlenhydratstoffwechsels in Deckschichten intakter und cariös veränderter Schmelzoberflächen menschlicher Zähne  

Microsoft Academic Search

Zusammenfassung  Um Aufschlu ber die Verteilung verschiedener Wege des mikrobiellen Intermedirstoffwechsels in der Deckschicht (DIS u. DCS) zu gewinnen, wurden die Aktivitten von Enzymen der Embden-Meyerhof-Kette, des Citrat-,Pentosephosphat und Glycerophosphatcyclus quantitativ im optischen Test bestimmt.Die Enzyme der PTG-Gruppe weisen auch in der Deckschicht ein proportionskonstantes Verhltnis ihrer Aktivitten zueinander auf. Die relativen Aktivitten der PTG-Gruppe zeigen jedoch, da in der Deckschicht

U. Garlichs; W. F. Hoppe

1969-01-01

26

Myriopoden von Ambon und anderen Inseln Der Banda-See  

Microsoft Academic Search

Dr. Kopstein auf Ambon hat dem Leidener Museum eine Anzahl von ihm gesammelter Myriopoden gesandt, deren Bestimmung ich übernommen habe. Das Material ist nicht gerade reichhaltig, zumeist nicht gut conserviert und umfasst lange nicht die gesammte dortige Fauna; trotzdem war auch etwas neues darin, die neuen Arten leider nur in je einem Stück; wie störend ein so geringes Material ist,

C. Attems

1927-01-01

27

Mutations in the A3 domain of von Willebrand factor inducing combined qualitative and quantitative defects in the protein.  

PubMed

Two unrelated families were recruited in the French Reference Center for von Willebrand Disease with moderate bleeding symptoms associated with low von Willebrand factor (VWF) antigen levels, decreased collagen binding assay, and no or partial response to desmopressin. Genetic analysis showed the presence of heterozygous mutations in the A3 domain away from the collagen-binding surface: 1 never reported previously (p.L1696R) and another (p.P1824H) described in a Spanish family. The mutations were reproduced by site-directed mutagenesis and mutant VWF was expressed in different expression systems, COS-7 cells, baby hamster kidney cells, and in VWF-deficient mice through hydrodynamic injection. p.L1696R and p.P1824H were associated with very low expression levels both in vitro and in vivo, with intracellular retention for p.P1824H. Both homozygous mutants displayed decreased binding to collagen types I and III but also decreased binding to platelet glycoproteins Ib and IIbIIIa. Co-transfections with wild-type VWF partially corrected these defects, except that collagen binding remained abnormal. The in vivo thrombosis response was severely reduced for both heterozygous mutants. In conclusion, we report 2 VWF A3 domain mutations that induce a combined qualitative and quantitative defect. PMID:23335371

Legendre, Paulette; Navarrete, Ana-Maria; Rayes, Julie; Casari, Caterina; Boisseau, Pierre; Ternisien, Catherine; Caron, Claudine; Fressinaud, Edith; Goudemand, Jenny; Veyradier, Agnès; Denis, Cécile V; Lenting, Peter J; Christophe, Olivier D

2013-01-18

28

Oxydierbarkeits- und Jodzahl zur Unterscheidung von Sprit und Essenzessig  

Microsoft Academic Search

Zusammenfassung Zusammenfassend läßt sich sagen, daß der Kaliumpermanganatverbrauch—O-Zahl—bei normalen Spritessigen zwischen 3,5–8 ccm 0,1 N.-Permanganatlösung liegt, wobei unter dieser Zahl der Verbrauch bis zur bleibenden Rotfärbung von 50 ccm mit verdünnter Schwefelsäure versetzten 3%-igen Essigs verstanden wird. Essenzessige erreichen dabei Werte von allerhöchstens 1–1,5 ccm, während Spritessige Werte bis zu 8 ccm und darüber erreichen können. Die Bestimmung ist vor

A. Schmidt

1935-01-01

29

Eine Waage für exotische Kerne: Massenbestimmung von Atomkernen mit Isoltrap  

NASA Astrophysics Data System (ADS)

Die präzise Massenbestimmung von Atomkernen ist für verschiedene Gebiete der Physik interessant. Penning-Fallen-Massenspektrometer wie Isoltrap am CERN können auch kurzlebige exotische Kerne wiegen, die zuvor im Labor erzeugt wurden. Die genaue Kenntnis ihrer Masse ist ein Schlüssel zum Verständnis dafür, wie Sterne, Novae und Supernovae Elemente erbrüten, die schwerer als Helium sind. Isoltrap ermöglicht auch einen Test des Standardmodells: Die präzise Bestimmung von Kernmassen vor und nach einem radioaktiven Zerfall liefert wichtige Informationen über die Natur der elektroschwachen Wechselwirkung.

Blaum, Klaus; Herfurth, Frank; Kellerbauer, Alban

2005-09-01

30

Infektionsepidemiologische Daten von Blutspendern 2003–2004  

Microsoft Academic Search

Die Erhebung infektionsepidemiologischer Daten zur Bestimmung der Prävalenz und Inzidenz von HIV-, Hepatitis-C-Virus- (HCV-), Hepatitis-B-Virus- (HBV-) und Syphilisinfektionen im Blut- und Plasmaspendewesen in Deutschland wird auf der Grundlage des §22 Transfusionsgesetz vom Robert Koch-Institut durchgeführt. Die vierteljährlich erhobenen Daten erlauben eine Aussage über die Infektionshäufigkeit in den Spenderkollektiven und somit indirekt eine Beurteilung der Sicherheit der gewonnenen Spenden. Der vorliegende

R. Offergeld; S. Ritter; D. Faensen; O. Hamouda

2005-01-01

31

Application of a method for matrix correction using compton-scattering for the quantitative determination of metals in silica by wavelength dispersive X-ray fluorescence spectroscopy (WDXRF)  

Microsoft Academic Search

Zusammenfassung Ein Korrekturverfahren zur Verminderung von Meßfehlern, die durch unterschiedliche Massenabsorptionskoeffizienten der Proben verursacht werden, wird beschrieben. Ebenso werden Fehler durch Schwankungen von Geräteparametern verringert. Die Methode wird benutzt zur Bestimmung von Fe, Cr, Ni, Cd, Co, Mn, Zn, Cu, Hg und Pb auf chemisch modifizierten Kieselgelen im µg\\/g-Bereich.

M. Lührmann; F. Wegener; A. Kettrup

1986-01-01

32

Quantitative ökologische Analyse eines Rifflagunenareals bei Aqaba (Golf von Aqaba, Rotes Meer)  

Microsoft Academic Search

Following previous investigations on a fringing reef in the Red Sea near Aqaba (Mergner & Schuhmacher, 1974; Mergner & Svoboda, 1977) this paper presents a quantitative analysis of the faunal and floral stock in one of the selected test areas (5×5 m) located in the reef lagoon studied. During the observation period 237 macrobenthic species of 192 genera were found.

H. Mergner

1979-01-01

33

Aufarbeitung von Meerestieren für die Bestimmung von PCB, DDT, DDE, DDD, ?-HCH und HCB  

Microsoft Academic Search

Frozen tissues are homogenized with quartz sand and Na2SO4. The resulting tissue powder is subjected to a cold extraction procedure with n-hexane\\/acetone (2?1) in a glass column. Clean-up of extracts is made on Al2O3 for fat removal and on florisil with 0.6–1.0% water content yielding two fractions which contain PCB's, DDE, HCB, and DDT, DDD, ?-HCH. The overall recovery is

W. Ernst; R. G. Schaefer; H. Goerke; G. Eder

1974-01-01

34

Signalparameter zur Ortung von HPEM-Quellen  

NASA Astrophysics Data System (ADS)

In diesem Beitrag wird anhand von Signalproben untersucht, mit welchen geeigneten Signalparametern die Ortung von aktiven leistungsstarken elektromagnetischen Quellen (sog. HPEM-Quellen) optimal durchgeführt werden kann. Da sich die Positionsberechnung durch die Verarbeitung von Laufzeitdifferenzen ergibt, beschränkt sich die Untersuchung auf die Bestimmung der Laufzeitdifferenzen. Betrachtet werden sowohl Signalausschnitte definierter Länge sowie eindeutig identifizierbare Ereigniszeitpunkte. Im ersten Fall werden aus der Korrelation der Signalausschnitte im Frequenzbereich die Laufzeitdifferenzen bestimmt. Hierbei wird durch Variation der Anzahl der Abtastwerte eines Signalausschnitts die erforderliche Signaldauer ermittelt. Im zweiten Fall werden zuerst aus den direkt erfassten Signaldaten die Einhüllenden gewonnen. Bezüglich eines vordefinierten Referenzwertes werden diese Einhüllenden dann korrigiert. Mit Hilfe eines festgelegten Schwellwertes wird abschließend aus den korrigierten Hüllkurven die Differenz der Ereigniszeitpunkte gebildet und somit die Laufzeitdifferenz im Zeitbereich bestimmt.

Kanyou Nana, R.; Kranzpiller, W.; Sonnenberg, N.; Nguete Tsamo, R.

2012-09-01

35

Photogrammetrische Untersuchung des Kniegelenks nach Implantation von Scharnierendoprothesen  

Microsoft Academic Search

Zusammenfassung  \\u000a Scharnierprothesen waren die ersten Implantate zum totalendoprothetischen Ersatz des Kniegelenks.Ihrer Konstruktion lag das\\u000a einfachste kinematische Modell,die Rotation um eine ortsstabile Flexions-Extensions-Achse, zugrunde.Inzwischen approximieren\\u000a Oberflächenersatzendoprothesen die biomechanischen Verhältnisse des Kniegelenks weit besser, sodass achsgeführte Prothesen\\u000a nur noch in Ausnahmefällen eingesetzt werden.\\u000a \\u000a \\u000a \\u000a Ziel der vorgestellten Untersuchung war die photogrammetrische Bestimmung von Projektionskurven der Flexions-Extensions-Achse\\u000a nach Implantation von Scharniergelenken. Der Vergleich mit

M. Schwitalle; E. M. Schwitalle; A. Just; S. Köller; T. Mark; F. Bodem

2003-01-01

36

Quantitative determination of ultra-traces of chlorinated compounds in high-volume air samples from the Arctic using polyurethane foam as collection medium  

Microsoft Academic Search

Das beschriebene Verfahren dient zur Bestimmung von chlorierten Verbindungen (chlorierte Benzole, Hexachlorcyclohexane, polychlorierte Biphenyle, DDT-Gruppe) in niedrigen Konzentrationen (pg\\/m3) in Luft. Da die meisten dieser Verbindungen gasförmig vorkommen, wurde eine Probenahmemethode für große Volumina unter Verwendung von sorgfältig vorgereinigtem Polyurethanschaum als Adsorptionsmedium entwickelt. Proben von 2000–4000 m3 wurden an verschiedenen Stellen der Arktis genommen. Die Vorbehandlung des Schaums und der

M. Oehme; H. Stray

1982-01-01

37

Quantitative and qualitative changes of von Willebrand factor and their impact on mortality in patients with end-stage kidney disease.  

PubMed

von Willebrand factor (vWF) antigen levels are elevated in patients with end-stage kidney disease (ESKD). We determined the quantitative and qualitative abnormalities of vWF and factors influencing vWF proteolysis in participants with ESKD compared with age-matched controls and determined the association between abnormalities in vWF and mortality over 4 years of follow-up. vWF?:?Ag and von Willebrand factor propeptide (vWFpp) levels, vWF functional activity (vWF?:RCo), vWF multimer profiles, ADAMTS-13, thrombospondin 1 (TSP-1), and interleukin 6 (IL-6) were evaluated before and after a single hemodialysis treatment in 55 individuals with vascular disease and an age-matched group of controls (n?=?21). vWF?:?Ag and vWF activity were significantly higher in the ESKD patients and levels increased further following the dialysis procedure. The percentage of high molecular weight multimers (%HMWMs) was significantly elevated in the ESKD patients compared with controls. TSP-1 was lower and IL-6 was higher providing possible explanation for the increase in %HMWM in ESKD. The %HMWM dropped significantly in the postdialysis sample. Mortality at 4 years was significantly associated with vWF?:?Ag. There are higher plasma vWF?:?Ag levels and a small increase in HMWMs in the ESKD milieu. The acute drop in the %HMWM of vWF postdialysis appears to be due to shear forces encountered during the dialysis procedure. The contribution of these abnormalities to either a pro-thrombotic and/or pro-bleeding phenotype in this population requires further study. PMID:23846000

Holden, Rachel M; Tuttle, Angie; Burbidge, Toni; Hegadorn, Carol; Grabell, Julie; Pruss, Cynthia; James, Paula D

2013-10-01

38

Neue biosensorische Prinzipien für die Hämoglobin-A1c Bestimmung  

NASA Astrophysics Data System (ADS)

Hämoglobin-A1c (HbA1c) ist ein Hämoglobin (Hb)-Subtypus, der durch nicht-enzymatische Glykierung des N-terminalen Valinrestes der Hämoglobin-beta-Kette entsteht. Das gemessene Verhältnis von HbA1c zum Gesamt-Hämoglobin (5-20 % bei Diabetikern) repräsentiert den Mittelwert der Blutglucosekonzentration über einen zweimonatigen Zeitraum und stellt zur Beurteilung der diabetischen Stoffwechsellage eine Ergänzung zur Akutkontrolle der Glukosekonzentration dar. Ziel der vorliegenden Arbeit war es, einen amperometrischen Biosensor für die Bestimmung des medizinisch relevanten Parameters HbA1c zu entwickeln. Durch Selektion geeigneter Bioerkennungselemente und deren Immobilisierung unter Erhalt der Bindungsfunktion für die Zielmoleküle Hämoglobin bzw. HbA1c wurden spezifische, hochaffine und regenerationsstabile Sensoroberflächen geschaffen. Für die Entwicklung des HbA1c-Biosensors wurden zwei Konzepte - Enzymsensor und Immunosensor - miteinander verglichen. Die enzymatische Umsetzung von HbA1c erfolgte mit der Fructosylamin Oxidase (FAO) aus Pichia pastoris N 1-1 unter Freisetzung von H2O2, welches sowohl optisch über eine Indikatorreaktion als auch elektrochemisch nach Einschluss der FAO in PVA-SbQ und Fixierung des Immobilisats vor einer H2O2-Elektrode nachgewiesen wurde. Die Kalibration des Enzymsensors mit der HbA1c-Modellsubstanz Fructosyl-Valin ergab Nachweisgrenzen, die ausserhalb des physiologisch relevanten HbA1c-Konzentrationsbereich lagen. Aus der Umsetzung von glykierten Peptiden mit einer nicht HbA1c analogen Aminosäurensequenz, z.B. Fructosyl-Valin-Glycin wurde zudem eine geringe HbA1c-Spezifität abgeleitet. Für den Immunosensor wurden zwei heterogene Immunoassay-Formate unter Verwendung von hochaffinen und spezifischen Antikörpern in Kombination mit Glucose Oxidase (GOD) als Markerenzym zum Nachweis von HbA1c untersucht. Beim indirekt-kompetitiven Immunoassay wurde anstelle des kompletten HbA1c-Moleküls das glykierte Pentapeptid Fructosyl-Valin-Histidin-Leucin-Threonin-Prolin (glkPP) als Kompetitor und Affinitätsligand immobilisiert und so eine regenerierfähige Oberfläche geschaffen. Beim Sandwich-Immunoassay wurde im ersten Schritt Gesamt-Hämoglobin an die mit Haptoglobin (Hp) modifizierte Festphase angereichert und im zweiten Schritt der gebundene HbA1c-Anteil nachgewiesen. Für die Konstruktion des HbA1c-Immunosensors wurden Affinitätsmatrizen durch Modifizierung von Cellulose-Dialysemembranen mit glkPP bzw. Hp hergestellt. Grundlegend studiert wurde die Aktivierung der Cellulose-Membranen mit 1,1'-Carbonyldiimidazol (CDI) und 1-Cyano-4-dimethylaminopyridintetrafluoroborat (CDAP) als Aktivierungsagenzien. Eine gerichtete Immobilisierung der Liganden wurde realisiert, indem glkPP über dessen C-Terminus (einzige Carboxylatgruppe) und Hp über dessen periodat-oxidiertem Kohlenhydratrest an die amino- oder hydrazidfunktionalisierte Membranen kovalent gekoppelt wurden. Mit dem Einsatz der glkPP- und Hp-modifizierten Membranen in der elektrochemischen Messzelle war erstmalig der biosensorische Nachweis von HbA1c möglich. Als Transduktor diente eine Pt-Elektrode, an der das von der GOD generierte H2O2 umgesetzt und ein mit der HbA1c-Konzentration korrelierendes Stromsignal erzeugt wurde. Die Immunosensoren zeigten Ansprechzeiten von 3 s. Mit dem Immunosensor auf Basis des indirekt-kompetitiven Testprinzips wurde eine Kalibrationskurve für HbA1c im Bereich von 0,25-30 µg/ml (3,9-465 nM, CV 3-9 %) mit Assayzeiten von 60 min und mit dem Immunosensor im Sandwich-Format eine Kalibrationskurve im Bereich von 0,5-5 µg/ml (7,8-78 nM; 5-50 % HbA1c vom Gesamt-Hb, CV 6-10 %, 3 h) aufgenommen. Hemoglobin-A1c (HbA1c) is a hemoglobin subtype formed by non-enzymatic reaction of glucose with the N-terminus of the beta-polypeptide chains. As it reflects the glycemic status of diabetics over the preceding 8-12 weeks, the determination of HbA1c has become an established procedure in the management of diabetes mellitus. It is measured as the percentage of total hemoglobin. Up to 5 % HbA1c are considered as

Stöllner, Daniela

2002-06-01

39

Bestimmung von Hydroxybenzoesäure-Verbindungen in Gewürzen und weiteren pflanzlichen Lebensmitteln  

Microsoft Academic Search

Summary The contents of six hydroxybenzoic acid glucosides and three 1-O-hydroxybenzoyl glucoses in spices and some other plants species were determined by means of capillary gas chromatography (GC) and high performance liquid chromatography (HPLC). As reference substances, salicylic acid (2-ß-d-glucoside), vanillic acid (4-ß-d-glucoside), syringic acid (4-ß-d-glucoside) and 1-0-ß-d-glucose esters of 4-hydroxybenzoic, vanillic, and syringic acids were synthesized. For sample clean-up,

Silke Klick; Karl Herrmann

1988-01-01

40

Bestimmung der Wasserdampf-Durchlaessigkeit von Baustoffen. (Determination of the water vapour transmission of building materials).  

National Technical Information Service (NTIS)

In the DIN 4108 part 4 apart from calculated values of the thermal conductivity also standard values of vapour diffusion resistance coefficients are given. For several building materials vapour diffusion resistance coefficients do not exist or are to chec...

P. Bernhardt M. Steingraber

1983-01-01

41

Energieverlustmessungen und bestimmung optischer konstanten von MgO und MgF2  

Microsoft Academic Search

Energy loss measurements on MgO and MgF2 applying 60 kV electrons are reported. From the energy loss function - Im[1\\/?(DeltaE)] the dielectric constant ? (DeltaE) is calculated from 0 to 80 eV by means of a Kramers-Kronig transformation. The results are compared with those of optical measurements and energy loss experiments of other authors.

H. Venghaus

1971-01-01

42

HPLC-Methode zur Bestimmung von vitamin C in Milch, Molke und Molkegetränken  

Microsoft Academic Search

Summary A method is described for the estimation ofl-ascorbic acid andl-dehydroascorbic acid in milk, whey, and whey drinks by paired-ion reversed-phase HPLC using a C18-column.l-ascorbic acid is detected UV-spectrophotometrically at 248 nm,l-dehydroascorbic acid is determined spectrofluorometrically with excitation at 350 nm and emission at 430 nm, after derivatisation into a quinoxaline fluorophor.

Wolfgang Kneifel; Regina Sommer

1985-01-01

43

Bestimmung von Uran und freier Säure in organischen Lösungen langkettiger Ammoniumnitrate  

Microsoft Academic Search

Uranium and free acid may be determined by potentiometric titration with alkali (Motojima and Izawa). The applicability of this method to solutions of long-chain tertiary and quaternary ammonium nitrates in organic solvents containing uranium and nitric acid has been studied. In solutions of quaternary ammonium nitrates, uranium and free acid may be determined by direct titration in a two-phase mixture,

Günter Koch

1965-01-01

44

‘CatWalk’ automated quantitative gait analysis as a novel method to assess mechanical allodynia in the rat; a comparison with von Frey testing  

Microsoft Academic Search

A characteristic symptom of neuropathic pain is mechanical allodynia. In animal models of neuropathic pain, mechanical allodynia is often assessed using von Frey filaments. Although the forces applied with these filaments are highly reproducible, there are various disadvantages of using this method. Testing paradigms and definitions of withdrawal threshold are not standardised. Moreover, measurements may be influenced by various conditions,

Dorien H Vrinten; Frank F. T Hamers

2003-01-01

45

von Willebrand Factor  

MedlinePLUS

... to be due (or actually be due) to hemophilia A, a factor VIII deficiency bleeding disorder that ... Know About von Willebrand Disease? World Federation of Hemophilia: What is von Willebrand disease (VWD)? Canadian Hemophilia ...

46

Bestimmung der Orientierung von Einkristallen mit unregelmässiger äusserer begrenzung mit hilfe des Röntgenspektrometers mit Registrierung mittels Gm-Zählerrohres  

Microsoft Academic Search

+ + + + IlpOBO~gaac~ op~e~Ta~ MOHOKpHcTaJIItOB repiaH~a. Ha HecKoJIhR~IX 06pa3ILax i4ccJIe~oBaJIocb HalipaBJIeHge pocwa. BI~IJIO 06Hapy~eHO, B cornac~ C pa6owaMI~ [3, 4], tIwo OCI) pocTa S MOIIOKpI~CTaJI~IaX repMaHi~a HallpaBzlella no [100], [110], [111] ~i [211]. Hanpan~ieHHe pocTa [211] scwpe~aeTca~acTo , Hei~oTop~Ie ~I~ oSpa~IWB, y I~OTOp~IX Hafi~eHO 0TO ~talipaBaellHepocTa, npeaCTaBJI~I:III~ C06OIO ~BO~IHI4K (5 IIJIOCI~OCTI, IO cpaCTaHHa [111]. 3AHdIIOqEHHE n 3aHJiioqellHe pe3ioMnpyeM

Marie Simerská

1956-01-01

47

Winkelkorrelationsmessungen an >30y Holmium 166 und Bestimmung des g R -Faktors des 4+-Rotationsniveaus von Erbium 166  

Microsoft Academic Search

The spins of several excited states of Er166 have been investigated by??-angular correlation measurements. The spin sequence 0+, 2+, 4+, 6+ for the ground state rotational band was presumed to be correct. Unique assignments were derived for the states of 1076 keV, 1377 keV and 1785 keV asI=5, 7 and 6 respectively. These results are in agreement with the spins

E. Gerdau; W. Krull; L. Mayer; J. Braunsfurth; J. Heisenberg; P. Steiner; E. Bodenstedt

1963-01-01

48

Winkelkorrelationsmessungen an >30y Holmium 166 und Bestimmung des g R -Faktors des 4+-Rotationsniveaus von Erbium 166  

Microsoft Academic Search

The spins of several excited states of Er166 have been investigated by gammagamma-angular correlation measurements. The spin sequence 0+, 2+, 4+, 6+ for the ground state rotational band was presumed to be correct. Unique assignments were derived for the states of 1076 keV, 1377 keV and 1785 keV as I=5, 7 and 6 respectively. These results are in agreement with

E. Gerdau; W. Krull; L. Mayer; J. Braunsfurth; J. Heisenberg; P. Steiner; E. Bodenstedt

1963-01-01

49

Untersuchung einer Methode zur Bestimmung von Blei, Cadmium, Quecksilber, Arsen und Tellur in Lebensmitteln mit Hilfe der Röntgenfluorescenzanalyse  

Microsoft Academic Search

The decomposition of food of animal origin with a mixture of nitric acid and sulphuric acid in a polyethylene flask at 60° C and with nitric acid in a steel vessel at 150° C was investigated. Both procedures give satisfactory results. The advantage of the second procedure lies in the small amounts of reagents needed, thus keeping blank values low.

H. Menke; Johannes Gutenberg-Universitfit; Fachbereich Chemie

1977-01-01

50

Einsatz der flammenlosen Atom-Absorption (Graphitrohrküvette) zur Bestimmung von Kupferspuren in Stahl und anderen Metall-Legierungen nach Extraktion  

Microsoft Academic Search

The determination of small and smallest amounts of copper in steel and other metal alloys by atomic absorption spectroscopy was investigated. It has been found, that the interferences caused by accompanying elements in the determination in aqueous solution with the flame can be completely removed by extracting the copper with Pb-DDTC in chloroform and determining this extract with the heated

A. Janßen; H. Melchior; D. Scholz

1977-01-01

51

Bestimmung der Wechselwirkungsparameter des menschlichen Gewebes für Monte-Carlo-Dosisberechnungen in der Strahlentherapie  

Microsoft Academic Search

Hintergrund: Monte-Carlo-Dosisberechnungsverfahren für klinische Photonen- und Elektronenstrahlung besitzen das Potential, die Dosis mit einer Genauigkeit von besser als DŽ% vorhersagen zu können. Um diese Präzision zu erreichen, ist jedoch die Kenntnis der Wechselwirkungseigenschaften in jedem Volumenelement essenziell. Material und Methoden: Es wird eine mögliche Methode für die Umrechnung von Massendichten in totale Wirkungsquerschnitte beschrieben. Diese Methode basiert auf einer detaillierten

Matthias Fippel; Fridtjof Nüsslin

2001-01-01

52

Rheologie von Beschichtungen  

NASA Astrophysics Data System (ADS)

Die Rheologie beschreibt die Fließ- und Deformationseigenschaften von Materialien. Der Begriff Rheologie ist aus dem Griechischen abgeleitet: rhein - fließen. Erst im Jahre 1930 entwickelte E.C. Bingham und M. Reiner in Easton (USA) die Rheologie zu einer eigenständigen Wissenschaft. Aber bereits seit dem 17. Jahrhundert wurden wesentliche Einzelbeiträge zu Fließphänomenen veröffentlich, so z.B. 1676 von R. Hooke (Hookesches Gesetz) und 1687 von I. Newton (Newtonsches Gesetz). Die Rheologie hat sich bis heute immer mehr zu einer interdisziplinären Wissenschaft entwickelt, die die mechanischen Eigenschaften von Materialien charakterisiert.

Schäffler, Michael

53

Leopold von Buch  

USGS Multimedia Gallery

This portrait of Leopold von Buch(1774-1853) was painted in the 1920s by Abner Lowe. Geologist, Paleontologist, and Graduate of the mining academy, Frieburg, Germany, von Buch is largely known for finding flaws in Abraham G. Werner's hypothesis (rocks from aqueous origins). Some of his more importan...

2009-07-22

54

Das Sicherheitskonzept von Java  

Microsoft Academic Search

Java eignet sich besonders gut zur Programmierung verteilter Applikationen in heterogenen Umgebungen, wobei mobiler Code neue Applikationen ermöglicht, bei denen Programmteile zur Laufzeit über das Netz geladen und ausgeführt werden. In jedem System mit mobilem Code muss der Sicherheit besondere Aufmerksamkeit geschenkt werden. Das Sicherheitskonzept von Java orientiert sich stark an der Programmierung von Applets, indem es die sichere Ausführung

Markus Pilz

55

Titanisierung von Implantatoberflächen  

NASA Astrophysics Data System (ADS)

Titan gilt seit Jahrzehnten als einer der wichtigsten Implantatwerkstoffe in der Medizin. Neben den guten mechanischen Eigenschaften (Leichtigkeit, hohe Festigkeit etc.), besitzen Titanimplantate vor allem eine hervorragende Körperverträglichkeit, so dass die Implantate optimal in den humanen Organismus integriert werden [1]. Ist jedoch aufgrund der Anforderungen an das Implantat eine hohe Flexibilität und/ oder Elastizität gefragt, so scheidet der Werkstoff Titan aufgrund seiner spröden und unflexiblen Materialeigenschaften aus. Die Folge ist der Einsatz von Implantatmaterialien, sowohl künstlichen als auch biologischen Ursprungs, welche nicht selten eine unzureichende Biokompatibilität aufweisen und somit zu Fremdköper- und immunologischen Reaktionen und Einkapselung des Implantates führen können. Die Erhöhung der Körperverträglichkeit, eine Adaption an das biologische Umfeld und eine hohe Biokompatibilität sind demzufolge die wichtigsten Eigenschaften bei der bedarfsgerechten Herstellung von Implantaten und Implantatoberflächen. Zur Gestaltung von innovativen, biokompatiblen Oberflächen stehen unterschiedliche technische Lösungsansätze zur Verfügung. Zum einen besteht die Möglichkeit, geeignete Oberflächeneigenschaften aus dem Grundmaterial selbst zu optimieren. Dies geschieht unter anderem durch Modifikation der Werkstoffoberflächen in Form von Texturierungen und Oberflächenrauhigkeiten. Zum anderen können die Oberflächeneigenschaften unabhängig von denen des Trägermaterials gestaltet werden. Durch Funktionalisierung der Oberflächen mit geeigneten Beschichtungen oder der Zugabe von Medikamenten (Drug Eluting) werden die Kunststoffimplantate dahingehend verändert, dass eine Steigerung der Körperakzeptanz erreicht wird. Die Titanbeschichtung von Implantatoberflächen kombiniert die positiven Materialeigenschaften von Titan und Polymer.

Zimmermann, Hanngörg; Heinlein, Markus; Guldner, Norbert W.

56

Elektrolytgehalt von Antibiotika  

Microsoft Academic Search

Zusammenfassung Der Elektrolytgehalt von Alkalisalzen häufig verwendeter Antibiotika wurde berechnet. Es konnte gezeigt werden, da? bei hochdosierter intravenöser Chemotherapie mitunter beträchtliche Mengen an Natrium oder Kalium mitinfundiert werden, die bei Elektrolytbilanzen berücksichtigt werden müssen. Bei Erkrankungen, die eine strenge Natriumrestriktion erfordern, kann die mitinfundierte Natriummenge ein Mehrfaches der beabsichtigten Tageszufuhr bedeuten. Die dargestellte Übersicht über den Elektrolytanteil von Antibiotika kann

H. Wiener; G. Kleinberger; K. Hruby

1981-01-01

57

Von Willebrand Disease  

MedlinePLUS

... disorders (including one you might have heard about — hemophilia) are rare. Von Willebrand disease is the most ... affecting about 1% to 2% of people. Unlike hemophilia, which usually affects only guys, vWD affects both ...

58

Energetische Verwertung von Biomasse  

NASA Astrophysics Data System (ADS)

Etwa 0,1% der Solarenergie wandeln sich durch Photosynthese aus dem Kohlendioxid der Luft in Biomasse um. Die Biomassen sind als Festbrennstoff nutzbar oder zu gasförmigen Brennstoffen weiterverarbeitbar. Zwei Arten von Biomassen sind zu unterscheiden: Anfallende Biomasse

Zahoransky, Richard; Allelein, Hans-Josef; Bollin, Elmar; Oehler, Helmut; Schelling, Udo

59

Konzeption von Kundenbeziehungsstrategien  

Microsoft Academic Search

\\u000a Kundenbeziehungen sind ein wesentlicher Erfolgstreiber von Unternehmen. Folglich kommt dem Management der Kundenbeziehungen(CRM) eine wichtige Rolle zu (Bruhn 2008a). CRM wird dabei häufig auf seine technologische Komponente reduziert und als IT-basiertes\\u000a CRM-System verstanden, dessen Aufgabe in der Sammlung und Auswertung von Kundendaten oder in der Automatisierung kundenbezogener\\u000a Prozesse liegt (Payne\\/Frow 2005, Hippner 2007). Obwohl moderne IT-Systeme nachweislich einen großen Beitrag

Dominik Georgi; Moritz Mink

60

Bewertung von Fahrzeuggeräuschen  

NASA Astrophysics Data System (ADS)

Bei der Wahrnehmung und Beurteilung eines Automobils sind unzählige Merkmale und Eigenschaften von Bedeutung. Dabei können Merkmale objektiv-technisch beschrieben werden, wie Angaben zur Motorisierung, Höchstgeschwindigkeit, Drehmoment, zulässige Zuladung, Verbrauch usw. Daneben sind weitere Eigenschaften von Bedeutung, die sich einer einfachen objektiv-technischen Beschreibung entziehen. Hier sind Begriffe zu nennen, wie Sicherheit, allgemeine Qualitätsanmutung, Design, Ergonomie, Komfort, Haptik, Fahrdynamik, Zuverlässigkeit, die deutlich schwieriger objektiv erfassbar und beschreibbar sind (Abb. 4.1).

Genuit, Klaus; Schulte-Fortkamp, Brigitte; Fiebig, André; Haverkamp, Michael

61

Bearbeitung von Ambivalenzen  

Microsoft Academic Search

\\u000a Einem Therapeuten kommen leicht Beispiele von Patienten in den Sinn, bei denen er oder sie Probleme hatte, konkrete Veränderungsschritte\\u000a einzuleiten. Beispielsweise berichtet ein Patient von ständiger Arbeitsüberlastung, aber unternimmt wenig, um diese Belastung\\u000a zu verringern, obwohl Patient und Therapeut es in der Therapie vorbesprochen haben. In solchen Situationen stellt sich der\\u000a Therapeut vielleicht die Frage, ob es dem Patienten nicht

Martin Grosse Holtforth; Johannes Michalak

62

Behandlung von Mittelhandfrakturen  

Microsoft Academic Search

Zusammenfassung  Das vorrangige Ziel der Behandlung von Mittelhandfrakturen ist die Wiederherstellung der Greiffunktion der Hand. Ob eine konservative\\u000a Therapie möglich ist, muss sowohl anhand radiologischer Kriterien als auch anhand des Ausmaßes der klinischen Fehlstellung\\u000a individuell entschieden werden. Für die operative Behandlungen von Frakturen im Kopf- und Schaftbereich haben sich weichteilschonende\\u000a Schrauben- und Plattenosteosynthesen bewährt sowie insbesondere für die Halsfrakturen der Randstrahlen

J. Windolf; J. M. Rueger; K. D. Werber; A. Eisenschenk; H. Siebert; M. Schädel-Höpfner

2009-01-01

63

Differential-thermoanalytische Untersuchungen an Magnesiten  

Microsoft Academic Search

Zusammenfassung Allgemeines über Differential-Thermoanalyse (DTA). Apparatur und Versuchsbedingungen. Einfluß der Korngröße auf die Meßgenauigkeit. DTA-Kurven von verschiedenen Magnesiten. Abbaukurven von Reinstkarbonaten (Magnesit, Calcit, Dolomit und Siderit). Mischreihe Calcit-Dolomit. Quantitative Auswertung der DTA-Kurven und Bestimmung des Mineralinhaltes. Möglichkeit der Messung der Kristallisationswärme des Magnesiumoxydes mit Hilfe der DTA. Zusammenfassung und Literaturübersicht.

P. Wieden

1954-01-01

64

Principles of care for the diagnosis and treatment of von Willebrand disease.  

PubMed

Von Willebrand disease is a common autosomal inherited bleeding disorder caused by quantitative or qualitative defects of von Willebrand factor, a multi-adhesive protein that binds platelets to exposed subendothelium and carries factor VIII in circulation. As a result of von Willebrand factor deficiency or abnormality, levels of factor VIII, the protein deficient in hemophilia A, may be variably reduced. Clinical manifestations are mainly represented by mucous membrane and of soft tissue bleeding. Their severity is variable depending on the degree of von Willebrand factor and factor VIII reduction. While a clear-cut diagnosis is easy in severe von Willebrand factor reductions, the advantage of pursuing a definite diagnosis in mild or dubious cases should be weighed against the risk of over-medicalization. The aim of treatment is to correct the dual defect of hemostasis caused by the abnormal/reduced von Willebrand factor and the concomitant deficiency of factor VIII. Desmopressin is the treatment of choice for type 1 von Willebrand disease patients with factor VIII and von Willebrand factor levels of 10 U/dL or over who have proved responsive to a test-infusion with the compound. Von Willebrand factor/factor VIII concentrates are needed when desmopressin is ineffective (mainly type 2 and 3 von Willebrand disease). PMID:23633542

Castaman, Giancarlo; Goodeve, Anne; Eikenboom, Jeroen

2013-05-01

65

Principles of care for the diagnosis and treatment of von Willebrand disease  

PubMed Central

Von Willebrand disease is a common autosomal inherited bleeding disorder caused by quantitative or qualitative defects of von Willebrand factor, a multi-adhesive protein that binds platelets to exposed subendothelium and carries factor VIII in circulation. As a result of von Willebrand factor deficiency or abnormality, levels of factor VIII, the protein deficient in hemophilia A, may be variably reduced. Clinical manifestations are mainly represented by mucous membrane and of soft tissue bleeding. Their severity is variable depending on the degree of von Willebrand factor and factor VIII reduction. While a clear-cut diagnosis is easy in severe von Willebrand factor reductions, the advantage of pursuing a definite diagnosis in mild or dubious cases should be weighed against the risk of over-medicalization. The aim of treatment is to correct the dual defect of hemostasis caused by the abnormal/reduced von Willebrand factor and the concomitant deficiency of factor VIII. Desmopressin is the treatment of choice for type 1 von Willebrand disease patients with factor VIII and von Willebrand factor levels of 10 U/dL or over who have proved responsive to a test-infusion with the compound. Von Willebrand factor/factor VIII concentrates are needed when desmopressin is ineffective (mainly type 2 and 3 von Willebrand disease).

Castaman, Giancarlo; Goodeve, Anne; Eikenboom, Jeroen

2013-01-01

66

Jenseits von Halley  

NASA Astrophysics Data System (ADS)

GIOTTO, das spektakulärste Raumprojekt seit der Mondlandung und ein Glanzstück der europäischen Raumforschung, wird von dem versierten Autor Nigel Calder spannend dargestellt. GIOTTO hat sich bis auf 600 km dem Kometen Halley genähert, wurde dabei beschädigt, von der Erde aus repariert und hat danach noch den Kometen Grigg-Skjellerup besucht. Das Buch führt den Leser durch alle Fehlschläge und die glanzvollen Erfolge dieser internationalen Zusammenarbeit unter der Leitung der ESA. Der Autor geht auch auf das ROSETTA-Projekt ein, das derzeit in Vorbereitung ist. Der Übersetzer hat in Zusammenarbeit mit dem Autor und den wissenschaftlichen Projektleitern bei der ESA den Text für die deutsche Ausgabe aktualisiert und ergänzt.

Calder, Nigel; Lüst, R.; Fischer, D.

67

Analytik von Lebensmittelallergenen  

NASA Astrophysics Data System (ADS)

Ansonsten harmlose Lebensmittel oder deren Bestandteile können bei von Lebensmittelallergien betroffenen Personen Überempfindlichkeitsreaktionen auslösen. Hierbei kann es sich um immunvermittelte Lebensmittelallergien oder um Intoleranzen gegenüber bestimmten Lebensmittelbestandteilen handeln. Ein Beispiel für Letzteres ist die Laktoseintoleranz, welche durch einen Enzymdefekt hervorgerufen wird [1]. Im Gegensatz hierzu handelt es sich bei Lebensmittelallergien um Sofortreaktionen, die durch IgE-Antikörper gegen Antigene aus den Lebensmitteln hervorgerufen werden und zu verschiedenen körperlichen Beschwerden führen können. Bei den Antigenen, welche von den von Allergikern produzierten IgE-Antikörpern erkannt werden, handelt es sich vor allem um Proteine [2]. Symptome IgE-vermittelter Reaktionen können zum Beispiel Hautausschlag, eine Schwellung der Schleimhäute oder das sogenannte orale Allergiesyndrom mit allergischen Reaktionen an der Mundschleimhaut und im Magen-Darm-Trakt sein [3]. Die hierbei auftretenden Beschwerden reichen von einem Brennen im Mund und einer Schwellung der Lippen und der Zunge bis zu Atemnot verursachenden Schwellungen im Kehlkopfbereich. In besonders schlimmen Fällen können allergische Reaktionen zu einem anaphylaktischen Schock und zum Tod durch Kreislaufversagen führen [4]. Während klassische Nahrungsallergene häufig komplexe Reaktionen zur Folge haben, ist bei Pollen-assoziierten Nahrungsmittelallergien das orale Allergiesyndrom vorherrschend.

Demmel, Anja; Hahn, Alexandra

68

BEGLEITTEXT: ÜBERPRÜFUNG VON KAUSALAUSSAGEN  

Microsoft Academic Search

Die logische Eleganz des mit dem obigen Beispiel skizzierten Schemas einer syllogistischen Erklärung beruht wesentlich darauf, dass es ein deterministisches Kausalgesetz voraussetzt. In der Forschungspraxis, also bei der empirischen Überprüfung von Kausalannah- men, wird aber realistischerweise kein Nachweis für eine deterministische, womöglich monokausale Bezie- hung angestrebt, man gibt sich vielmehr mit einer pro- babilistischen und unvollständigen Erklärung durch eine oder

Peter Schmolck

2008-01-01

69

Nitratreduktaseaktivität von Kartoffelsorten  

Microsoft Academic Search

Die Aktivität der Nitratreduktase (NRA) in der Wurzel von Kartoffeln beträgt nur ca. 1\\/10 der Aktivität der oberen Blätter. 5 Std. nach Beginn der Lichtperiode erreichte die NRA in den Blättern ein Maximum. In der Vegetationsperiode durchläuft die NRA der oberen Blätter ein 1. Maximum während des intensiven Längenwachstums, ein 2 kleineres gegen Ende der Vegetationsperiode. Die nachgewiesenen Sortenunterschiede in

H. Von Meltzer

1987-01-01

70

[von Recklinghausen's neurofibromatosis].  

PubMed

We present a case of unusual clinical picture of the well defined Morbus Von Recklinghausen. In a 35-year-old male patient, after an uncontrolled rapid movement of the neck, the disease was suddenly manifested with spastic quadriparesis. Three years later the clinical picture showed spastic quadriplegia. Antalgic torticollis confirmed by X-ray of the neck clearly showed vertebral subluxation at the level of C3-C4. However, additional magnetic resonance imaging revealed large extradural tumorous formation at the level of C1-C2, and two small oval tumours in the splenium of the corpus callosum as well as in the left lateral ventricle. "Café au lait" spots, "molluscum fibrosum" and few subcutaneous fibromas appeared as skin changes which explained the possible nature of the registered intracranial and intraspinal tumours. Neurosurgery has been performed at the spinal level with good results; it confirmed the diagnosis of Von Recklinghausen's Neurofibromatosis. PMID:1807001

Alcaz, S; Djordjevi?, M; Dragutinovi?, G; Lavrni?, S; Apostolski, S

71

Zur Physiologie von Sportbewegungen  

Microsoft Academic Search

Zusammenfassung  In einer Folge von Mitteilungen soll versucht werden, in Beiträgen zur Physiologie der Sportbewegungen eine angewandte sportliche Bewegungslehre in einigen wesentlichen Grundzügen herauszuarbeiten.1. \\u000aDie erste Mitteilung behandelt in Anlehnung an arbeitsphysiologische Gedankengänge dieFragestellung, welche im Sinne einer angewandten Bewegungslehre für eine Synthese physiologisch-bewegungsanalytischer Ergebnisse und einer Lehre der Bewegungen in der Praxis erforderlich wäre.\\u000aEs wird gezeigt, daß diese zumindest

O. Schmith

1932-01-01

72

VON THÜNEN AND URBAN SPRAWL  

Microsoft Academic Search

In explaining agricultural patterns near urban areas, Von Thünen's theory is generally applicable where the primary force determining the pattern is transport cost to the market. When this is the case, the pattern of agricultural land use is one of decreasing intensity with distance from the city. Von Thünen's theory still applies in underdeveloped parts of the world, but his

ROBERT SINCLAIR

1967-01-01

73

Extraktion von DNA  

NASA Astrophysics Data System (ADS)

Eine DNA-gestützte Analytik spielt im Lebensmittelbereich eine große Rolle. So wird die PCR bzw. die Real Time PCR z. B. für den Nachweis von Krankheitserreger in Lebensmitteln, zur Tier- und Pflanzenartendifferenzierung und den Nachweis von gentechnologisch veränderten Organismen eingesetzt [1]. Grundvoraussetzung für die sehr sensitiven molekularbiologischen Methoden ist eine saubere und kontaminationsfreie Nukleinsäure [2]. Die Qualität der Nukleinsäure entscheidet über Erfolg und Misserfolg der anschließenden molekularbiologischen Analytik. Deshalb werden im Bereich der Lebensmittelanalytik hohe Anforderungen an das jeweilige DNA-Extraktionsprotokoll gestellt. Durch die Anwendung eines geeigneten Extraktionsverfahrens soll die nachzuweisende DNA möglichst in hochmolekularer Form und frei von die nachfolgende Analytik hemmenden Substanzen vorliegen [1]. Gerade hier stellt die Natur der Lebensmittelmatrix eine besondere Herausforderung dar. Matrixkomponenten wie Fette, Zucker, Proteine und sekundäre Inhaltsstoffe erschweren die DNA-Extraktion und können, wenn sie nicht durch die Extraktion vollständig entfernt werden, zu einer Inhibierung der PCR führen [3]. Des Weiteren müssen auf der Matrixoberfläche vorhandene DNA-abbauende Enzyme gehemmt werden [1]. Daneben spielt der Einfluss verschiedener chemischer und physikalischer Parameter (pH-Wert, Temperatur, Enzyme, Scherkräfte) bei der Lebensmittelproduktion eine große Rolle für die Qualität der extrahierten DNA. So führen z. B. hohe Temperaturen und saure pH-Werte während der Lebensmittelverarbeitung zu einer Fragmentierung der DNA. Auch die physikalischen und chemischen Bedingungen der verwendeten Extraktionsmethode beeinflussen die Qualität der DNA [2]. Bleiben nach der Extraktion organische Lösungsmittel (Phenol, Ethanol), Enzyme, Proteine oder Salze zurück, können diese ebenfalls eine nachfolgende PCR inhibieren. Um eine Inhibition der PCR auszuschließen, sollten in der nachfolgenden Analytik entsprechende Inhibitionskontrollen mitgeführt werden [3].

Pöpping, Bert; Unterberger, Claudia

74

Messung des g R -Faktors des 2+-Rotationsniveaus von Dy 160 nach der Spinrotationsmethode und Bestimmung der Multipolmischungen mehrerer ?-Übergänge im Zerfall des Tb 160  

Microsoft Academic Search

A differential measurement of the spin rotation of Dy160 in the 2+ rotational state was performed by using liquid sources of TbCl3 solved in 3M HCl and applying an external magnetic field of 33 500 Gauss. No change of the Larmor precession frequency could be detected within the first 10·10?9 s. It is concluded that the ground state of the

C. Günther; G. Strube; U. Wehmann; W. Engels; H. Blumberg; H. Luig; R. M. Lieder; E. Bodenstedt; H. J. Körner

1965-01-01

75

Messung des gR-Faktors des 2+-Rotationsniveaus von Dy160 nach der Spinrotationsmethode und Bestimmung der Multipolmischungen mehrerer gamma-Übergänge im Zerfall des Tb160  

Microsoft Academic Search

A differential measurement of the spin rotation of Dy160 in the 2+ rotational state was performed by using liquid sources of TbCl3 solved in 3 M HCl and applying an external magnetic field of 33 500 Gauss. No change of the Larmor precession frequency could be detected within the first 10·10-9 s. It is concluded that the ground state of

C. Günther; G. Strube; U. Wehmann; W. Engels; H. Blumberg; H. Luig; R. M. Lieder; E. Bodenstedt; H. J. Körner

1965-01-01

76

Bestimmung von Boeen Gemessen an Einem 130M-Mast bei Wilhelmshaven (Shape of Wind Gusts at a 130M Tower at Wilhelmshaven (Germany)).  

National Technical Information Service (NTIS)

A tower equipped with wind sensors at different levels above the ground is described. The tower had a triangular cross section with a side length of 1 m; the length of the sensor carrying booms was slightly more than 3 m, thus minimizing the wake effects ...

G. Tetzlaff K. Schreiber M. Kotzian J. Rissmann E. Hollwurtel

1992-01-01

77

Nichtwässrige derivative Headspace Festphasenmikroextraktion in Verbin- dung mit GC-MS in der Haaranalyse - eine sensitive Methode zur Bestimmung von Cannabis und Alkoholmissbrauch  

Microsoft Academic Search

Objective: In general, headspace solid phase microextraction (HS-SPME) as a method of sample preparation of hair for drugs is performed from aqueous hair hydrolysates or hair extracts. Therefore, the method is limited to an extraction temperature below the boiling point of the aqueous phase (100-120 °C, depending on the salt content) and cannot be combined with in- sample derivatization by

Johannes Schräder; Thomas Nadulski; Fritz Pragst

78

Energetische Verwertung von Biomasse  

Microsoft Academic Search

\\u000a Etwa 0,1% der Solarenergie wandeln sich durch Photosynthese aus dem Kohlendioxid der Luft in Biomasse um. Die Biomassen sind\\u000a als Festbrennstoff nutzbar oder zu gasförmigen Brennstoffen weiterverarbeitbar. Zwei Arten von Biomassen sind zu unterscheiden:\\u000a \\u000a \\u000a \\u000a \\u000a • \\u000a \\u000a \\u000a Anfallende Biomasse\\u000a \\u000a \\u000a \\u000a • \\u000a \\u000a \\u000a Angebaute Biomasse

Richard Zahoransky; Hans-Josef Allelein; Elmar Bollin; Helmut Oehler; Udo Schelling

2010-01-01

79

Autoradiographische Bestimmung der DNS-Verdopplungszeit und anderer Teil-Phasen des Zell-Zyklus bei fetalen Zellarten der Ratte  

Microsoft Academic Search

Bei Ratten-Feten am 20. Tag der Gravidität wurden bei einer Reihe von Zellarten die DNS-Verdopplungszeit (S-Phase), die Generationszeit und die anderen Teil-Phasen des Zell-Zyklus nach zwei verschiedenen Methoden bestimmt.

K. Wegener; S. Hollweg; W. Maurer

1964-01-01

80

Missbrauchspotential von Verzeichnisdienst-Metadaten in LDAP-basierten System- und Benutzerverwaltungen  

NASA Astrophysics Data System (ADS)

Metadaten stellen Zusatzinformationen über elektronisch gespeicherte Kerninformationen zur Verfügung. Sie ergänzen die eigentliche Hauptinformation um nützliche Details. In vielen Bereichen werden Metadaten gespeichert und stehen zur Auswertung zur Verfügung. Alle IT-nahen Systeme, angefangen im Konsumerbereich (z.B. digitale Kameras) bis hin zu unternehmenskritischen Applikationen führen im Hintergrund Metadaten - parallel zu den eigentlichen Hauptdaten. Metadaten im Allgemeinen sind per se als neutral, d.h. weder positiv noch negativ, zu bewerten. So wirken sich diese häufig positiv auf das Finden und Sortieren von digitalen Dokumenten aus. Negativ treten Metadaten eigentlich immer nur dann in Erscheinung, sobald diese ursprünglich zusätzlichen und nützlichen (und daher im Gegensatz zu den Hauptdaten nicht besonders beachteten bzw. geschützten) Informationen entgegen ihrer Bestimmung, zweckentfremdet werden. Auch Verzeichnisdienste verfügen über solche nützlichen Metadaten zu den jeweils in ihnen gespeicherten Inhalten. Ob, und wenn ja wie weit diese nützlichen Inhalte auch ein Risiko darstellen können wird im Rahmen dieses Artikels anhand eines konkreten Szenarios aus dem Umfeld des Systemmanagements gezeigt.

Pluta, Daniel

81

Herbert Von Karajan Center  

NSDL National Science Digital Library

Born in 1908, Maestro Herbert Von Karajan was probably Salzburg's most favored son since the time of Mozart. Known for his passionate and stirring conducting style, along with his elaborate opera productions, Maestro Karajan and his body of work lives on at the Herbert Von Karajan Center in Vienna. The inviting interface of the Web site offers users a section about Karajan, along with several brief multimedia clips of his recordings and a chronology of his many different activities, including his four decade association with the Berlin Philharmonic. Along with the audio clips are some video clips of Karajan rehearsing with the Vienna Philharmonic in 1965. As the Center is a massive repository of material relating to the 3300 concerts and opera performances undertaken by Karajan, a searchable database provides detailed information about each engagement. Not surprisingly, the site also has a complete archive of his hundreds and hundreds of musical recordings, searchable by composer, composition title, or musician. For anyone with an interest in one of the 20th century's most celebrated conductors, this site should not be missed.

2001-01-01

82

Sulfation of von Willebrand factor  

SciTech Connect

von Willebrand factor (vWF) is a multimeric adhesive glycoprotein essential for normal hemostasis. We have discovered that cultured human umbilical vein endothelial cells incorporate inorganic sulfate into vWF. Following immunoisolation and analysis by polyacrylamide or agarose gel electrophoresis, metabolically labeled vWF was found to have incorporated (35S)-sulfate into all secreted multimer species. The time course of incorporation shows that sulfation occurs late in the biosynthesis of vWF, near the point at which multimerization occurs. Quantitative analysis suggests the presence, on average, of one molecule of sulfate per mature vWF subunit. Virtually all the detectable sulfate is released from the mature vWF subunit by treatment with endoglycosidases that remove asparagine-linked carbohydrates. Sulfated carbohydrate was localized first to the N-terminal half of the mature subunit (amino acids 1 through 1,365) by partial proteolytic digestion with protease V8; and subsequently to a smaller fragment within this region (amino acids 273 through 511) by sequential digestions with protease V8 and trypsin. Thus, the carbohydrate at asparagine 384 and/or 468 appears to be the site of sulfate modification. Sodium chlorate, an inhibitor of adenosine triphosphate-sulfurylase, blocks sulfation of vWF without affecting either the ability of vWF to assemble into high molecular weight multimers or the ability of vWF multimers to enter Weible-Palade bodies. The stability of vWF multimers in the presence of an endothelial cell monolayer also was unaffected by the sulfation state. Additionally, we have found that the cleaved propeptide of vWF is sulfated on asparagine-linked carbohydrate.

Carew, J.A.; Browning, P.J.; Lynch, D.C. (Harvard Medical School, Boston, MA (USA))

1990-12-15

83

Wolfgang von Ohnesorge  

NASA Astrophysics Data System (ADS)

This manuscript got started when one of us (G.H.M.) presented a lecture at the Institute of Mathematics and its Applications at the University of Minnesota. The presentation included a photograph of Rayleigh and made frequent mention of the Ohnesorge number. When the other of us (M.R.) enquired about a picture of Ohnesorge, we found out that none were readily available on the web. Indeed, little about Ohnesorge is available from easily accessible public sources. A good part of the reason is certainly that, unlike other ``numbermen'' of fluid mechanics, Ohnesorge did not pursue an academic career. The purpose of this article is to fill the gap and shed some light on the life of Wolfgang von Ohnesorge. We shall discuss the highlights of his biography, his scientific contributions, their physical significance, and their impact today.

McKinley, Gareth H.; Renardy, Michael

2011-12-01

84

On the versatility of von Willebrand factor.  

PubMed

Von Willebrand factor (VWF) is a large multimeric protein, the function of which has been demonstrated to be pivotal to the haemostatic system. Indeed, quantitative and/or qualitative abnormalities of VWF are associated with the bleeding disorder Von Willebrand disease (VWD). Moreover, increased plasma concentrations of VWF have been linked to an increased risk for thrombotic complications. In the previous decades, many studies have contributed to our understanding of how VWF is connected to the haemostatic system, particularly with regard to structure-function relationships. Interactive sites for important ligands of VWF (such as factor VIII, collagen, glycoprotein Ib?, integrin ?IIb?3 and protease ADAMTS13) have been identified, and mutagenesis studies have confirmed the physiological relevance of the interactions between VWF and these ligands. However, we have also become aware that VWF has a more versatile character than previously thought, given its potential role in various non-hemostatic processes, like intimal thickening, tumor cell apoptosis and inflammatory processes. In the presence review, a summary of our knowledge on VWF structure-function relationships is provided in the context of the "classical" haemostatic task of VWF and in perspective of pathological processes beyond haemostasis. PMID:23936617

Rauch, Antoine; Wohner, Nikolett; Christophe, Olivier D; Denis, Cécile V; Susen, Sophie; Lenting, Peter J

2013-07-10

85

Von Willebrand disease: screening, diagnosis, and management.  

PubMed

Von Willebrand disease (vWD), a hemorrhagic disorder mimicking a defect in platelet function, is the most commonly inherited coagulopathy, resulting in a deficiency that may prolong bleeding time and increase risk for major bleeding complications during surgery. Von Willebrand factor (vWF) serves a dual role in hemostasis: mediating the initial platelet adhesion to damaged endothelium at the site of vessel injury and stabilizing coagulation factor VIII, an important cofactor in the generation of a fibrin clot. Although quantitative or qualitative defects in vWF protein can manifest as a mild to severe bleeding disorder, many cases of vWD remain subclinical, barring major invasive stimuli, and undetected by either patient or clinician. Nevertheless, the frequency of this coagulation disorder would almost ensure that every plastic surgeon will encounter affected patients, making a thorough understanding of vWD and its management absolutely necessary. Surprisingly, there is little information concerning vWD in the plastic surgery literature. Our goal is to familiarize the plastic surgeon with vWD, including physiology, diagnostic criteria, classification, and molecular basis for multiple vWD variants, and diagnosis and management. PMID:19083526

Totonchi, Ali; Eshraghi, Yashar; Beck, Daniel; McCrae, Keith; Guyuron, Bahman

86

On the Versatility of von Willebrand Factor  

PubMed Central

Von Willebrand factor (VWF) is a large multimeric protein, the function of which has been demonstrated to be pivotal to the haemostatic system. Indeed, quantitative and/or qualitative abnormalities of VWF are associated with the bleeding disorder Von Willebrand disease (VWD). Moreover, increased plasma concentrations of VWF have been linked to an increased risk for thrombotic complications. In the previous decades, many studies have contributed to our understanding of how VWF is connected to the haemostatic system, particularly with regard to structure-function relationships. Interactive sites for important ligands of VWF (such as factor VIII, collagen, glycoprotein Ib?, integrin ?IIb?3 and protease ADAMTS13) have been identified, and mutagenesis studies have confirmed the physiological relevance of the interactions between VWF and these ligands. However, we have also become aware that VWF has a more versatile character than previously thought, given its potential role in various non-hemostatic processes, like intimal thickening, tumor cell apoptosis and inflammatory processes. In the presence review, a summary of our knowledge on VWF structure-function relationships is provided in the context of the “classical” haemostatic task of VWF and in perspective of pathological processes beyond haemostasis.

Rauch, Antoine; Wohner, Nikolett; Christophe, Olivier D.; Denis, Cecile V.; Susen, Sophie; Lenting, Peter J.

2013-01-01

87

Renaturierung von Sandökosystemen im Binnenland  

NASA Astrophysics Data System (ADS)

Das Vorkommen von Sandökosystemen im Binnenland (Flugsand- und Decksandfelder, Dünen) ist vor allem an Sand-Akkumulationen der vorletzten Eiszeit (in Nordeuropa: Saaleeiszeit und Sand-Ablagerungen an größeren Flüssen gebunden. So finden wir die Verbreitungsschwerpunkte von binnenländischen Sandökosystemen in Mitteleuropa einerseits vor allem im Bereich der flächenhaften saalezeitlichen Ablagerungen in den Niederlanden und in Norddeutschland (Castel et al. 1989), andererseits kommen Sandökosysteme des Binnenlandes linear in den Flussgebieten z.B. von Maas, Rhein, Ems, Elbe, Oder und Regnitz vor. In Niederösterreich fanden sich einst großflächige Dünen- und Flugsandgebiete im Marchfeld östlich von Wien (Wiesbauer et al. 1997). Die Flugsandbildung setzte bereits im Spätglazial ca. 11000 v. Chr. ein, als eine den Sand fixierende Vegetation noch fehlte. Es bildeten sich im norddeutschen Raum aus den leicht verwehbaren Talsanden bereits um 9000 v. Chr.

Schwabe-Kratochwil, Angelika; Kratochwil, Anselm

88

Von Willebrand Disease (For Parents)  

MedlinePLUS

... in 1926. As a group, bleeding disorders (including hemophilia ) are rare. Von Willebrand disease is the most ... and the mildest form of the disease. Unlike hemophilia, which affects only boys, vWD affects boys and ...

89

Paraffindispersionen zur Hydrophobierung von Spanplatten  

Microsoft Academic Search

Zusammenfassung  Zur Hydrophobierung von Holzspanplatten werden fast ausschlielich Paraffindispersionen eingesetzt. In dieser Arbeit werden\\u000a die wesentlichen Merkmale der Paraffine und ihre Wirkungsweise in der Spanplatte besprochen, und es werden Hinweise zur Herstellung\\u000a und Verarbeitung von Paraffindispersionen gegeben. Zur Aufbringung auf das Spangut kann die Dispersion dem Bindemittel untergemischt\\u000a oder getrennt verdst werden. Beide Verfahren werden in ihren Vor- und Nachteilen gegenbergestellt.

Jan Amthor

1972-01-01

90

Struktur und Funktion von Propaganda  

Microsoft Academic Search

Zusammenfassungen  Der vorliegende Beitrag resümiert zunächst klassische Begriffe und Konzepte von Propaganda und arbeitet in einem ersten Zugriff\\u000a eine vergleichende Typologie struktureller Merkmale von Propaganda heraus. Dabei erweist sich Propaganda als kommunikative\\u000a Technik zur Erzeugung Wahrheit reklamierender, gleichwohl nicht hinterfragbarer Versprechen mit generalisierender Struktur:\\u000a Sachlich durch Reklamierung eines Alleinvertretungsanspruchs, der temporal auf Dauer gestellt wird und als sozial bindend akzeptiert gilt.

Klaus Merten

2000-01-01

91

Ein Wechsellichtmonochromator für Spektrallinien von ausgedehnten Lichtquellen  

Microsoft Academic Search

Zusammenfassung Es wird ein „Wechsellichtfilter“ angegeben, bei dem nur das von einer Spektrallinie erzeugte Interferenzstreifensystem Wechsellicht hervorbringt, während insbesondere kontinuierliches Licht keine Wirkung.hat. Mit einer Interferenzplatte variabler Dicke kann die Anordnung für alle Wehenlängen verwendet werden. Die „Filterkurve“ des Geräts, d.h. der von Licht nicht optimaler Wellenlänge erzeugte Wechsellichtstrom, wird berechnet und gemessen. Sie wird durch zwei Perioden bestimmt, von

G. Ehgartner; W. Piepenbrink; H. Maier-Leibnitz

1955-01-01

92

Konsistenzmessungen von Gummi-Benzollösungen  

Microsoft Academic Search

Zusammenfassung  \\u000a \\u000a \\u000a \\u000a 1. \\u000a \\u000a Von den Gleichungen, die die Strmung durch eine Kapillarrhre ausdrcken, ist\\u000a \\u000a \\u000a \\u000a \\u000a $$\\\\frac{{d^4 (P - k)^n }}{{Lq}} = 1$$\\u000a \\u000a \\u000a \\u000a \\u000a \\u000a die fr Lsungen von Rohgummi in Benzol bis zu einer Konzentration von 1,2 Proz. am besten anwendbare.\\u000a \\u000a \\u000a \\u000a \\u000a 2. \\u000a \\u000a Die Methode der Konsistenzbestimmung durch Benutzung dieser Gleichung hat den Vorteil, da sie verwendbare Werte fr alle\\u000a praktischen Strmungsgeschwindigkeiten liefert und da

Winslow H. Herschel; Ronald Bulkley

1926-01-01

93

Research on Purity ExAmination of Calcium by Spectral Analysis. I. Spectrographic Determination of Li, B, Al, Si, and Cu. Report No. 58\\/VIII; VERSUCHE UBER SPEKTRALANALYTISCHE REINHEITSPRUFUNG VON CALCIUM I. SPEKTROGRAPHISCHE BESTIMMUNG VON Li, B, Al, Si, Cu  

Microsoft Academic Search

Spectrographic methods for the determination of Li, B, Al, Si, and Cu in ; Ca of nuclear purity are given. The conditions for each analysis are tabulated, ; and the results obtained are presented. (J.S.R.);

S. Held; S. Skalska

1958-01-01

94

Soziale Mobilität von Drogenkonsumenten  

Microsoft Academic Search

A total of 351 drug-users (127 in-patients of the university hospital for nervous diseases Frankfurt a. Main, 124 out-patients of the special health centre in the city of Frankfurt a. Main) were steadily investigated between the years 1969\\/70 with the aid of a fixed catalogue consisting of 386 single criterions with quantitative and qualitative alternatives. The informations for instance on

K. Wanke; E. Leiser; L. Süllwold; B. Ziegler

1972-01-01

95

Exponential size distribution of von Willebrand factor.  

PubMed

Von Willebrand Factor (VWF) is a multimeric protein crucial for hemostasis. Under shear flow, it acts as a mechanosensor responding with a size-dependent globule-stretch transition to increasing shear rates. Here, we quantify for the first time, to our knowledge, the size distribution of recombinant VWF and VWF-eGFP using a multilateral approach that involves quantitative gel analysis, fluorescence correlation spectroscopy, and total internal reflection fluorescence microscopy. We find an exponentially decaying size distribution of multimers for recombinant VWF as well as for VWF derived from blood samples in accordance with the notion of a step-growth polymerization process during VWF biosynthesis. The distribution is solely described by the extent of polymerization, which was found to be reduced in the case of the pathologically relevant mutant VWF-IIC. The VWF-specific protease ADAMTS13 systematically shifts the VWF size distribution toward smaller sizes. This dynamic evolution is monitored using fluorescence correlation spectroscopy and compared to a computer simulation of a random cleavage process relating ADAMTS13 concentration to the degree of VWF breakdown. Quantitative assessment of VWF size distribution in terms of an exponential might prove to be useful both as a valuable biophysical characterization and as a possible disease indicator for clinical applications. PMID:24010664

Lippok, Svenja; Obser, Tobias; Müller, Jochen P; Stierle, Valentin K; Benoit, Martin; Budde, Ulrich; Schneppenheim, Reinhard; Rädler, Joachim O

2013-09-01

96

Leitlinien zur Implantation von Defibrillatoren  

Microsoft Academic Search

Die vorliegenden Leitlinien zur Implan- tation von Defibrillatoren wurden in Überarbeitung der Leitlinien der Deut- schen Gesellschaft für Kardiologie, Herz und Kreislaufforschung, wie sie 1993 publiziert worden sind, erstellt, ba- sierend auf einer sorgfältigen Analyse der wissenschaftlichen Daten zur aktu- ellen Therapie ventrikulärer Tachy- arrhythmien. Auch in Zukunft sollen diese Leitlinien in regelmäßigen Ab- ständen revidiert werden, wenn der wissenschaftliche

W. Jung; D. Andresen; M. Block; D. Böcker; S. H. Hohnloser; K.-H. Kuck; J. Sperzel; G. Ertl; M. Böhm; M. Borggrefe; J. Brachmann; F. de Haan; A. Osterspey; S. Silber; H. J. Trappe; G. Arnold; H. M. Hoffmeister; E. Fleck

97

Quantitative analysis  

PubMed Central

Quantitative analysis permits the isolation of invariant relations in the study of behavior. The parameters of these relations can serve as higher-order dependent variables in more extensive analyses. These points are illustrated by reference to quantitative descriptions of performance maintained by concurrent schedules, multiple schedules, and signal-detection procedures. Such quantitative descriptions of empirical data may be derived from mathematical theories, which in turn can lead to novel empirical analyses so long as their terms refer to behavioral and environmental events. Thus, quantitative analysis is an integral aspect of the experimental analysis of behavior.

Nevin, John A.

1984-01-01

98

Quantitative fractography  

Microsoft Academic Search

In many disciplines, such as biology, botany, geology, materials science and medicine, quantitative image analysis is being used to an increasing extent. In materials science this technique makes it possible to relate the microsctructure to the mechanical properties. In this review we shall show that image analysis can be applied in a fractographic study to characterize quantitatively the morphology of

J. L. Chermant; M. Coster

1979-01-01

99

Homozygous and heterozygous deletions of the von Willebrand factor gene in patients and carriers of sever von Willebrand disease  

SciTech Connect

Severe von Willebrand disease is characterized by undetectable or trace quantities of von Willebrand factor in plasma and tissue stores. The authors have studied the genomic DNA of 10 affected individuals from six families with this disorder using probes from the 5' and 3' ends of the vWF cDNA and with a probe extending from the 5' end into the central region. Southern blots of restriction endonuclease digest and gene dosage analysis measurements carried out with quantitative slot blots of undigested genomic DNA separated these patients into three groups. The first group consisted of a family with complete homozygous deletions of the vWF gene in the four probands. The second group was comprised of a family in which there was a complete heterozygous deletion of the vWF gene in the proband and one asymptomatic parent, suggesting that a different type of genetic abnormality was inherited from the other parent. Thus, the patient appeared to be doubly heterozygous for interacting genetic abnormalities affecting vWF expression. In the third group, no gene deletions could be detected. Alloantibodies developed only in the kindred with homozygous deletions. These techniques should prove useful in identifying carriers of severe von Willebrand disease and also in defining patients predictably at risk of developing alloantibodes to vWF.

Ngo, K.Y.; Glotz, V.T.; Koziol, J.A.; Lynch, D.C.; Gitschier, J.; Ranieri, P.; Ciavarella, N.; Ruggeri, Z.M.; Zimmerman, T.S.

1988-04-01

100

Duplikationen von Untereinheiten der chromosomalen DNS während der Evolution von Chironomus thummi  

Microsoft Academic Search

1.An Feulgen-gefärbten Speicheldrüsen-Chromosomen des Unterart-Bastards von Chironomus thummi wurden 30 verschiedene Querscheiben auf subspezifische Differenzen des DNS-Gehalts cytophotometrisch untersucht. Mit der gleichen Technik wurde die Höhe von DNS-Differenzen an den heterochromatischen Kinetochorscheiben der Speicheldrüsen-Chromosomen von Chironomus plumosus bestimmt.2.Bei subspezifischer Differenz des DNS-Gehalts enthalten die Querscheiben von Ch. thummi thummi das 2-, 4-, 8- oder 16fache an DNS wie ihre Homologen

H.-G. Keyl

1965-01-01

101

Verlassen von Vater und Mutter  

Microsoft Academic Search

Zusammenfassung  Ab dem Jahr 2000 erhielt die Babyklappe durch die Medien erhöhte Aufmerksamkeit. Die im Mittelalter von der Kirche eingeführte\\u000a Einrichtung der Drehlade wurde wieder aufgenommen. Findelkinder haben in der Gesellschaft immer eine besondere Rolle gespielt\\u000a (Moses, Romulus und Remus, Kaspar Hauser usw.). Das erste Findelhaus entstand im Jahre 787 in Mailand. Die erste Drehlade\\u000a wurde einer Legende nach im Ospedale

V. Lehmann; K. Friese; J. W. Schumann

2007-01-01

102

Nutzung von Social Media für die Marketingforschung  

Microsoft Academic Search

\\u000a Mit der Verbreitung von Web 2.0 Anwendungen, sogenannter Social Software hat sich das Kommunikationsverhalten von Konsumentinnen\\u000a und Konsumenten radikal verändert. Die Möglichkeiten, im Internet einfach Informationen zu publizieren und sich dabei unabhängig\\u000a von Institutionen und klassischen Medien auszutauschen, hat eine kreative Revolution ausgelöst. Über Social Software findet\\u000a ein zunehmend interaktiver Austausch zwischen der Kundschaft und den Unternehmen statt. Konsumentinnen und

Seraina Mohr; Dorothea Schaffner

103

Der Einsatz von Trichogramma -Schlupfwespen in Deutschland  

Microsoft Academic Search

Zusammenfassung Die Anwendung von Trichogramma-Eiparasitoiden hat weiter zugenommen. Der Einsatz von T. brassicae gegen den Maiszünsler Ostrinia nubilalis hat mit 11.000 ha in Deutschland den größten Anteil. Im Obstbau wurde der kommerzielle Einsatz von T. cacoeciae und T. dendrolimi gegen den Apfelwickler Cydia pomonella und den Pflaumenwickler Grapholita funebrana im Kleingartenbereich ausgeweitet. Zur Bekämpfung der Traubenwickler Lobesia botrana und Eupoecilia ambiguella an Hausreben werden

Olaf Zimmermann

2004-01-01

104

Enthemmende Wirkung von Metallen auf die hydrazingehemmte enzymatische Oxydation von Cadaverin  

Microsoft Academic Search

1. Untersucht wurde sowhol die verhindernde wie auch die aufhebende Wirkung von Fe, Cu, Co, Ni und Mn auf die Hemmwirkung von zwei Benzdiazinen, 1-Hydrazino-phthalazin und 2,4-Dihydrazino-chinazolin (Präp. 12630), sowie von Isonicotinsäurehydrazid (I.N.H.) auf die Histaminase-Cadaverin-Reaktion.

W. Schuler; R. Meier

1954-01-01

105

Antihemophilic Factor/von Willebrand Factor Complex  

Center for Biologics Evaluation and Research (CBER)

... About the Center for Biologics Evaluation and Research. -. Antihemophilic Factor/von Willebrand Factor Complex. -. Products. ... More results from www.fda.gov/biologicsbloodvaccines/bloodbloodproducts/approvedproducts

106

Infektionsrisiko bei postoperativer autogener Retransfusion von Drainageblut  

Microsoft Academic Search

Zusammenfassung Die Retransfusion postoperativ gesammelten Drainageblutes ist eine bei orthopädischen Eingriffen weit verbreitete Methode zur Einsparung von Fremdblutkonserven. Vorteile gegenüber der Verwendung homogener Blutkonserven bestehen darin, dass immunologische Reaktionen auf Fremdblut unterbleiben und Infektionskrankheiten nicht übertragen werden können. Nachteilig ist die Gefahr der Sekundärverkeimung und der hämatogenen Streuung von Infektionen. Zur Verringerung dieser Risiken werden folgende Maßnahmen empfohlen: Die Kontraindikationen

Martin Handel; Stefan Sell; Peter Heeg

2001-01-01

107

Die kombinierte Kompressionsmarknagelarthrodese von OSG und USG  

Microsoft Academic Search

Zusammenfassung Die operative Versteifung von oberem (OSG) und unterem Sprunggelenk (USG) ist bei fortgeschrittenen degenerativen Veränderungen beider Gelenke unterschiedlicher Genese auch bei zunehmender Verbreitung des Oberflächenersatzes am OSG die Therapie der Wahl. Bisher sind verschiedene Techniken zur tibiotalokalkanealen Arthrodese beschrieben worden, wobei sich die Kompressionsarthrodese mit internen Implantaten durchgesetzt hat. 20 Patienten, bei denen die kombinierte Arthrodese von OSG und

M. Goebel; T. Mückley; L. Gerdesmeyer; M. Militz; V. Bühren

2003-01-01

108

Franz Xaver von Zach in England  

NASA Astrophysics Data System (ADS)

F.X. von Zach arrived in London in November 1783, and was employed as tutor to George, son of Count von Brühl, the Saxonian commercial diplomat. Von Zach became a part of von Brühl's household, and was thus in close contact with the leading astronomers, horologists, and scientific instrument makers. Before he departed to Gotha in 1788, he was awarded an honorary degree by Oxford University under false pretences, he upset the Astronomer Royal, and was twice rejected by the Royal Society. At von Brühl's country house he was shown the manuscripts of the mathematician Thomas Harriot (d. 1621); but his attempts to publicise them were hampered by his misreadings, and his treatment of the documents caused confusion in England's scientific community, which lasted throughout his lifetime.

McConnell, Anita

109

QUANTITATIVE MORPHOLOGY  

EPA Science Inventory

Abstract: In toxicology, the role of quantitative assessment of brain morphology can be understood in the context of two types of treatment-related alterations. One type of alteration is specifically associated with treatment and is not observed in control animals. Measurement ...

110

Beitrag zur Untersuchung und Beurteilung von schwarzem Tee  

Microsoft Academic Search

Zusammenfassung 1.Es wurde versucht, bei den verschiedenen im Handel befindlichen Teesorten mit Hilfe einer stark vergrößernden Lupe Blatt, Rippe und Stengel auszusortieren, was im wesentlichen gelang.2.Als Beurteilungsgrundlage für Tee wurden herangezogen: Wassergehalt, wäßriger Extrakt, Coffeingehalt, Gerbstoffgehalt; Gesamtasche und, als neuere Versuche, die Bestimmung der sog. Oxydationszahl und der Chloraminzahl, wobei unter 0-Zahl die Anzahl Kubikzentimeter 0,01 n-KMnO4-Lösung verstanden werden, die

A. Schmidt

1952-01-01

111

Der totale Wirkungsquerschnitt und der Diffusionsstreuquerschnitt von Hartree-Potentialen  

Microsoft Academic Search

Wie bekannt führt die Theorie der Elektronenstöße an neutralen Atomen zu einem Mehrelektronenproblem. Die wichtigsten wellenmechanischen Näherungsverfahren für die Elektronenstoßprobleme an Atomen sind das Variationsverfahren und die Methode des self consistent field von Hartree, bzw. von Hartree und Fock. Das wellenmechanische Variationsverfahren ist mit mathematischen Schwierigkeiten verbunden. Mit Hilfe der von Hartree entwickelten Methode des self-consistent field, welche von Fock

T. Tietz

1958-01-01

112

Die Wirkung von Calciumdobesilat (Doxium R ) auf die Bildung von Kollagengelen als Glaskörperersatz  

Microsoft Academic Search

Zusammenfassung  Aus Lösungen von Typ I Kollagen können unter geeigneten Bedingungen stabile Gele dargestellt werden (Schmut und Ehgartner,\\u000a Spektrum Augenheilkd. (1988) 2, 200). Die Gelbildung mit Lösungen von Glaskörperkollagen zur Darstellung eines biologischen\\u000a Glaskörperersatzes gelingt nach dieser Methode erst nach Zusatz von Calciumdobesilat (DoxiumR). Ohne Calciumdobesilat tritt aus diesen Lösungen keine Gelbildung ein. Die Wirkung ist auf den Dobesilatanteil und nicht

O. Schmut

1991-01-01

113

Two cases of peritonsillar abscess complicated by von Willebrand disease.  

PubMed

Von Willebrand disease (vWD) is a common hereditary bleeding disorder resulting from a quantitative and/or qualitative deficiency of von Willebrand factor (vWF). We report two cases of peritonsillar abscess complicated by vWD. A 46-year-old Japanese man was intravenously administered factor VIII clotting antigen (500U×3 days)and platelet transfusion (10U), when before puncture was performed. After puncture, his symptoms promptly improved with the administration of the antibiotic doripenem (DRPM, 1.5g/day). He left our facility one week later and had no recurrence of symptoms. A 24-year-old Japanese woman was intravenously administered factor VIII clotting antigen (4500U×3 days) and desmopressin (DDAVP) before undergoing a puncture. Her symptoms promptly improved with DRPM treatment (1.5g/day). The patient left our facility one week later. However, the peritonsillar abscess recurred in three weeks. Afterwards, tonsillectomy was enforced three months later. Intravenous factor VIII clotting antigen (4500U×2 days) and platelet transfusion (10U×1 day) had been used before tonsillectomy. We therefore suggest that a peritonsillar abscess in patients with vWD can be safely treated by factor VIII clotting antigen and DDAVP at the appropriate disease stage and by performing paracentesis for the acute phase or tonsillectomy for the chronic phase. PMID:22075138

Nagano, Hiromi; Harada, Mizue; Umakoshi, Mizuo; Hayamizu, Yoshiko; Yoshifuku, Kosuke; Kurono, Yuichi

2011-11-08

114

Clinical Measurement of von Willebrand Factor by Fluorescence Correlation Spectroscopy  

PubMed Central

BACKGROUND Identification of von Willebrand factor (vWF) abnormalities in a variety of conditions is hampered by the limitations of currently available diagnostic tests. Although direct multimer visualization by immunoelectrophoresis is a commonly used method, it is impractical as a routine clinical test. In this study, we used a biophysical analysis tool, fluorescence correlation spectroscopy (FCS), to measure vWF distributions. The goals were to develop a method that is quicker and simpler than vWF gel electrophoresis and to evaluate the potential of FCS as a clinical diagnostic technique. METHODS We analyzed plasma from 12 patients with type 1 von Willebrand disease (vWD), 14 patients with type 2 vWD, and 10 healthy controls using a fluctuation-based immunoassay approach. RESULTS FCS enabled identification and proper classification of type 1 and type 2 vWD, producing quantitative results that correspond to qualitative gel multimer patterns. FCS required minimal sample preparation and only a 5-min analysis time. CONCLUSIONS This study represents the first implementation of FCS for clinical diagnostics directly on human plasma. The technique shows potential for further vWF studies and as a generally applicable laboratory test method.

Torres, Richard; Genzen, Jonathan R.; Levene, Michael J.

2013-01-01

115

Social Science of Carl von Clausewitz.  

National Technical Information Service (NTIS)

Carl von Clausewitz's great, unfinished book 'On War' is well-known as being prone to misinterpretation and distortion. At the risk of adding to the veritable cottage industry of distortion, this article attempts to add conceptual clarity by demonstrating...

J. Klinger

2006-01-01

116

Herstellung von Chitosan und einige Anwendungen  

NASA Astrophysics Data System (ADS)

1. Die Deacetylierung von crabshell - Chitosan führte gleichzeitig zu einem drastischen Abfall der mittleren viscosimetrischen Molmasse ( Mv), insbesondere wenn die Temperatur und die Konzentration an NaOH erhöht werden. Diese Parameter beeinflussten jedoch nicht den Grad der Deacetylierung (DD). Wichtig ist jedoch die Quelle des Ausgangsmaterials: Chitin aus Pandalus borealis ist ein guter Rohstoff für die Herstellung von Chitosan mit niedrigem DD und gleichzeitig hoher mittlerer Mv, während Krill-Chitin (Euphausia superba) ein gutes Ausgangsmaterial zur Herstellung von Chitosan mit hohem DD und niedrigem Mv ist. Chitosan, das aus Insekten (Calliphora erythrocephala), unter milden Bedingungen (Temperatur: 100°C, NaOH-Konzentration: 40 %, Zeit: 1-2h ) hergestellt wurde, hatte die gleichen Eigenschaften hinsichtlich DD und Mv wie das aus Krill hergestellte Chitosan. Der Bedarf an Zeit, Energie und NaOH ist für die Herstellung von Insekten-Chitosan geringer als für crabshell-Chitosan vergleichbare Resultaten für DD und Mv. 2. Chitosan wurde durch den Schimmelpilz Aspergillus fumigatus zu Chitooligomeren fermentiert. Die Ausbeute beträgt 25%. Die Chitooligomere wurden mit Hilfe von HPLC und MALDI-TOF-Massenspektrmetrie identifiziert. Die Fermentationsmischung fördert die Immunität von Pflanzen gegen Bakterien und Virusinfektion. Die Zunahme der Immunität schwankt jedoch je nach System Pflanze-Pathogen. Die Fermentation von Chitosan durch Aspergillus fumigatus könnte eine schnelle und billige Methode zur Herstellung von Chitooligomeren mit guter Reinheit und Ausbeute sein. Eine partiell aufgereinigte Fermentationsmischung dieser Art könnte in der Landwirtschaft als Pathogeninhibitor genutzt werden. Durch kontrollierte Fermentation, die Chitooligomere in definierter Zusammensetzung (d.h. definierter Verteilung des Depolymerisationsgrades) liefert, könnte man zu Mischungen kommen, die für die jeweilige Anwendung eine optimale Bioaktivität besitzen. 3. Die aus Chitosan-Dispersionen hergestellten MCChB-Filme weisen bessere mechanische Eigenschaften (Bruchfestigkeit, Dehnung) und eine höhere Wasseraufnahmefähigkeit auf als Filme, die nach herkömmlichen Methoden aus sauerer Lösung hergestellt werden. Die Einführung von Proteinen ändert die mechanischen Eigenschaften der MCChB-Filme abhängig von der Art, der Proteine sowie des DD und der Mv des eingesetzte Chitosan. Die Zugabe von Protein beschleunigt den biologischen Abbau der MCChB-Filme. Aus den untersuchten MCChB-Filmen mit Proteinzusatz können leichte, reißfeste und dennoch elastische Materialen hergestellt werden. 4. Mit Hilfe von MCChB-Dispersion kann Papier modifiziert werden. Dadurch werden die mechanischen Eigenschaften verbessert und die Wasseraufnahme wird verringert. Die Zugabe von Proteinen verringert das Wasseraufnahmevermögen noch weiter. Ein geringes Wasseraufnahmevermögen ist der bedeutendste Faktor bei der Papierherstellung. Auch Papier, das mit einem MCChB-Protein-Komplexe modifiziert wurde, zeigt gute mechanische Eigenschaften. 5. Wird Chitosan durch unmittelbare Einführung von MCChB auf Cellulose-Fasern aufgebracht, so erhält man eine netzartige Struktur, während durch Ausfällung aufgebrachtes Chitosan eine dünne Schicht auf den Cellulose-Fasern bildet. Die netzartige Struktur erleichtert die Bioabbaubarkeit, während die Schichtstruktur diese erschwert. 6. Die guten mechanischen Eigenschaften, die geringe Wasseraufnahmefähigkeit und die mit Cellulose vergleichbare Bioabbaubarkeit von Papier, das mit MCChB modifiziert wurde, lassen MCChB für die Veredlung von Papier nützlich erscheinen. 1. Deacetylation of the crustacean chitosan causes drastically decrease in the Mv with increasing reaction temperature and time as well as the concentration of sodium hydroxide. However, the DD are relatively less affected. Pandalus borealis is a good source for production of chitosan having high Mv and low DD, whereas chitosan of medium to low Mv can ideally be prepared using krill chitin. Insect chitosan is prepared under milder condition a

Struszczyk, Marcin Henryk

2001-05-01

117

Entkopplungsmöglichkeiten von Fabry-Perot-Interferometern  

Microsoft Academic Search

Die Aufstellung von 2 Fabry-Perot-Interferometern in Tandem wurde von Gehrcke und Lau [17] sowie durch Houston [18] zuerst benutzt. Seitdem haben sich viele Autoren mit den Problemen, die bei der Kombination mehrerer FP's entstehen, eingehend beschäftigt. Eine der störenden Erscheinungen beruht auf der Kopplung der aufeinanderfolgenden FP-Filter, da ihre Wirkung nicht durch Absorption zustandekommt. Deshalb ist man bestrebt, eine Entkopplung

J. Schwider

1965-01-01

118

Nonsense mutations of the von Willebrand factor gene in patients with von Willebrand disease type III and type I  

SciTech Connect

von Willebrand disease (vWD) is the most common inherited bleeding disorder in humans. The disease is caused by qualitative and quantitative abnormalities of the von Willebrand factor (vWF). Genomic DNA from 25 patients with vWD type III, the most severe form of the disease, was studied using PCR followed by restriction-enzyme analysis and direct sequencing of the products. Nonsense mutations (CGA[yields]TGA) were detected in exons 28, 32, and 45 by screening of all 11 CGA arginine codons of the vWF gene. Two patients were found to be homozygous and five heterozygous for the mutation. Both parents and some of the relatives of the homozygous patients carry the mutation. These are the first reported examples of homozygous point mutations associated with the severe form of vWD. In the three heterozygous probands, one of the parents carried the mutation and had vWD type I. Family studies including parents and family members with or without vWD type I indicted that these three heterozygous patients are likely to be compound heterozygous. Twenty-one individuals from these seven families with vWD type I found to be heterozygous for the mutation. 21 refs., 5 figs., 4 tabs.

Zhang, Z.P.; Lindstedt, M.; Falk, G.; Blombaeck, M.; Egberg, N.; Anvret, M. (Karolinska Hospital, Stockholm (Sweden))

1992-10-01

119

Quantitative Literacy  

NSDL National Science Digital Library

This resource guide from the Middle School Portal 2 project, written specifically for teachers, provides links to exemplary resources including background information, lessons, career information, and related national science education standards.On this wiki page, you will find online lessons, activities, and projects that allow students a range of real-world contexts. The Content Collections section contains sites that offer sets of problems and illustrations that connect middle school math to down-to-earth settings. The Interdisciplinary Lessons and Activities section offers activities and projects ready for interdisciplinary teaching. Each of the following sections focuses on a math topic: Data Analysis and Display, Probability, Measurement, Number and Operations. The resources offer mathematics in settings that deliberately cross over into other areas of the curriculum. Finally, for teachers looking for support in teaching quantitative literacy, a new approach for us all, Background Information for Teachers presents a select set of professional resources.

Herrera, Terese

2009-04-01

120

War and the Austrian School: Ludwig von Mises and Friedrich von Hayek  

Microsoft Academic Search

The Austrian school of economics is generally considered an antiwar school. The Austrian view is not derived from a religious or class-based ideological viewpoints, but instead derives entirely from the school’s fundamental economic tenets. This article examines the writings of Ludwig von Mises and Friedrich von Hayek as they relate to war and the causes of war. [An predecessor article

Christopher Westley; William L. Anderson; Scott A. Kjar

2011-01-01

121

The role of von Willebrand factor and ADAMTS13 in the no-reflow phenomenon: after primary percutaneous coronary intervention.  

PubMed

We prospectively studied the correlations between plasma levels of von Willebrand factor and its cleaving protease--a disintegrin and metalloproteinase with thrombospondin type I motif, member 13 (ADAMTS13)--in 126 patients who did or did not develop no-reflow phenomenon after primary percutaneous intervention for acute ST-segment-elevation myocardial infarction. Quantitative plasma levels of von Willebrand factor and ADAMTS13 were measured by immunoturbidometric assay.Angiographic no-reflow was observed in 46 (37%) of the 126 patients. At admission, plasma levels of von Willebrand factor were significantly higher in the no-reflow group (P < 0.001), but levels of ADAMTS13 at admission were similar in the 2 groups (P = 0.143). At logistic regression, after adjustment for serum creatinine, left ventricular ejection fraction, high-sensitivity C-reactive protein, and N-terminal pro B-type natriuretic peptide, plasma von Willebrand factor level at admission (? 5,531 mU/mL) was still the predictive factor for the no-reflow phenomenon. The area under the receiver operating characteristics curve was 0.785.Our results suggest that high von Willebrand factor level is related to the no-reflow phenomenon in such a way that it might be a predictor of the phenomenon. PMID:22163125

Zhao, Bilian; Li, Jian; Luo, Xinping; Zhou, Qing; Chen, Hua; Shi, Haiming

2011-01-01

122

A rapid method for determining ATP by the firefly luciferin-luciferase system  

Microsoft Academic Search

Zusammenfassung Eine schnelle Methode zur Bestimmung von ATP in picogramm-Mengen wird beschrieben. Die Grundlage für die Methode ist eine Reaktion zwischen ATP und einem Inkubationsansatz, der Luciferin, Mg2+ und partiell gereinigte Luciferase enthält, und ist zur Bestimmung von ATP in biologischem Material von unterschiedlicher Beschaffenheit (Bakterien, Pflanzen-und Tiergewebe) geeignet.

H. A. Neufeld; R. D. Towner; Judith Pace

1975-01-01

123

Über das Schmelzverhalten von dehnungsinduzierter Kristallisation am Beispiel des Naturkautschuk  

Microsoft Academic Search

Zusammenfassung Kalorimetrisch und mit Röntgenmessungen wurde das Schmelzverhalten von verstrecktem Naturkautschuk untersucht. Die Proben wurden bei Zimmertemperatur verstreckt und die Verstreckung während des Aufheizens konstant gehalten. Für das Aufschmelzen ergab sich ein weiter Schmelzbereich, der sofort nach Aufheizbeginn einsetzt, das Schmelzende ist vom Dehnungsgrad abhängig. Ein Vergleich von Schmelzende und Verstreckgrad mit der Theorie vonFlory ergab nur bei Verwendung eines

W. Sietz; D. Göritz; F. H. Müller

1974-01-01

124

Zelltyp-spezifische Mikroanalyse von Arabidopsis thaliana-Blättern  

Microsoft Academic Search

Im ersten Teil der Arbeit wurden Strategien zur Analyse von Transkripten erarbeitet. Die ersten Versuche zielten darauf ab, in mit Glaskapillaren genommenen Einzelzellproben verschiedener Gewebeschichten RT-PCR durchzuführen, um spezifische Transkripte nachweisen zu können. Dies gelang für eine Reihe von Genen aus verschiedenen Pflanzenspezies. Dabei konnten sowohl Transkripte stark wie auch schwach exprimierter Gene nachgewiesen werden. Für die Erstellung von Gewebe-spezifischen

Stephan Peter Brandt

2002-01-01

125

A Selective History of the Stone-von Neumann Theorem  

Microsoft Academic Search

The names of Stone and von Neumann are intertwined in what is now known as the Stone-von Neumann Theorem. We discuss the origins of this theorem, the contributions to it of Stone and von Neumann, the ways the theorem has been reformulated, and some of the varied mathematics that has grown out of it. At the end we discuss certain

Jonathan Rosenberg

126

Der sog. Midvastus-Zugang zur Implantation von Kniegelenkendoprothesen  

Microsoft Academic Search

Zusammenfassung Operationsziel Zugang zum Kniegelenk zur Implantation von Kniegelenkendoprothesen in der Absicht, Lateralisationstendenzen der Kniescheibe und Streckdefizite zu vermeiden. Indikationen Implantation von Knieendoprothesen. Revisionseingriffe nach Alloarthroplastik. Kontraindikationen Hochgradige Adipositas. Revisionseingriffe mit präoperativer Flexion des Kniegelenks Operationstechnik Längsschnitt über der Vorderseite des Kniegelenks, stumpfes Auseinanderdrängen der distalen, schräg verlaufenden Muskelfasern des Musculus vastus medialis auf einer Länge von mindestens 5 cm

Robert Hube; Nicholas G. Sotereanos; Heiko Reichel

2002-01-01

127

Die antibakterielle Effektivität von Cefamandol im Vergleich mit anderen Antibiotika  

Microsoft Academic Search

Zusammenfassung Die antibakterielle Aktivität von Cefamandol wurde mit der Wirksamkeit von Cefuroxim, Cefoxitin, Cephalotin, Ampicillin, Mezlocillin, Azlocillin, Ticarcillin und Tobramycin bei 450 gramnegativen Bakterien sowie bei 150 grampositiven Kokken verglichen. Bei den grampositiven Bakterien wurde zusätzlich die Wirksamkeit von Penicillin und Oxacillin geprüft. Bestimmt wurden die minimalen Hemmkonzentrationen und minimalen bakteriziden Konzentrationen (partielle und totale) mittels Reihenverdünnungstest in Mueller-Hinton-Bouillon (Difco).

H.-H. Schassan

1978-01-01

128

Stagnation point von Kármán coefficient.  

PubMed

On the basis of various direct numerical simulations (DNS) of turbulent channel flows the following picture is proposed. (i) At a distance y from either wall, the Taylor microscale lambda is proportional to the average distance l(s) between stagnation points of the fluctuating velocity field, i.e., lambda(y)=B(1)l(s)(y) with B(1) constant, for delta(nu) < y < or approximately equal to delta, where the wall unit delta(nu) is defined as the ratio of kinematic viscosity nu to skin friction velocity u(tau) and delta is the channel's half-width. (ii) The number density n(s) of stagnation points varies with height according to n(s)=(C(s)/delta(nu)(3))y(+)(-1) where y(+) identical with y/delta(nu) and C(s) is constant in the range delta(nu) < y < or approximately equal to delta. (iii) In that same range, the kinetic energy dissipation rate per unit mass, equals 2/3(E(+)((u(tau)(3)/kappa(s)y) where E(+) is the total kinetic energy per unit mass normalized by u(tau)(2) and kappa(s)=B(1)(2)/C(s) is the stagnation point von Kármán coefficient. (iv) In the limit of exceedingly large Reynolds numbers Re(tau) identical with delta/delta(nu), large enough for the Reynolds stress -(uv) to equal u(tau)(2) in the range delta(nu) < y < delta, and assuming that production of turbulent kinetic energy balances dissipation locally in that range and limit, the mean velocity U(+), normalized by u(tau), obeys (d/dy)U(+) approximately equal to 2/3(E(+)/kappa(s)y) in that same range. (v) It follows that the von Kármán coefficient kappa is a meaningful and well-defined coefficient and the log law holds in turbulent channel/pipe flows only if E(+) is independent of y(+) and Re(tau) in that range, in which case kappa approximately kappa(s). (vi) In support of (d/dy)U(+) approximately equal to 2/3(E(+)/kappa(s)y), DNS data of turbulent channel flows which include the highest currently available values of Re(tau) are best fitted by E(+) approximately equal to 2/3(B(4)y(+)(-2/15)) and (d/dy(+))U(+) approximately equal to (B(4)/kappa(s))y(+)(-1-2/15) with B4 independent of y in delta(nu) < y < delta if the significant departure from -(uv) approximately equal to u(tau)(2) at these Re(tau) values is taken into account. PMID:19905435

Dallas, V; Vassilicos, J C; Hewitt, G F

2009-10-06

129

Der dorsale Zugang zur Implantation von Hüftendoprothesen  

Microsoft Academic Search

Zusammenfassung\\u000a Operationsziel  Schonender Zugang zum Hüftgelenk mit geringem Verletzungsrisiko von Gefäßen und Nerven, geringem Blutverlust und guter Übersicht\\u000a über koxales Femurende, Hüftpfanne und hinteren Beckenpfeiler.\\u000a \\u000a \\u000a \\u000a Indikationen  Implantation von Endoprothesen, Prothesenwechsel und Azetabulumfrakturen mit Abbruch des hinteren Pfeilers.\\u000a \\u000a \\u000a \\u000a Kontraindikationen  Keine.\\u000a \\u000a \\u000a \\u000a Operationstechnik  Von einer bogenförmigen Hautinzision vom Gesäß über den Schenkelhals und Trochanter major nach distal wird der Musculus glutaeus\\u000a maximus vom Musculus glutaeus medius sowie

Eckhart Engelbrecht; Thorsten Gehrke

1997-01-01

130

Thyminnucleotid-Synthese und Proliferation von Knochenmarkzellen bei megaloblastären Anämien unter der Einwirkung von Vitamin B 12  

Microsoft Academic Search

Zusammenfassung Am Knochenmark von vier Patienten mit megaloblastären Anämien wurden vor und nach i.m. Injektion von 1000 µg Vitamin B12 in Form von Cyanocobalamin die bei der Thyminnucleotid-Synthese beteiligten Enzyme FH2-Reductase und Thymidinkinase, der Mitoseindex, der DNS-Gehalt in der Einzelzelle und der in vitro-Einbau von3H-Thymidin untersucht:1Der Anteil in DNS-Synthese befindlicher Zellen ist in der megaloblastären Erythropoese und Granulopoese im Durchschnitt

H. E. Bock; J. Hartje; D. Müller; W. Wilmanns

1967-01-01

131

Umweltbedingte Ursachen von Benetzungsstörungen der Augenoberfläche  

Microsoft Academic Search

\\u000a Zusammenfassung  Der weltweit beobachtete Anstieg von Benetzungsstörungen der Augenoberfläche lässt sich zum Teil durch die Zunahme exogener\\u000a Einflüsse, wie Computerarbeit, Klimaanlagen, die Einnahme bestimmter Medikamente u. a. erklären.\\u000a \\u000a Wir untersuchten den Einfluss von Umweltfaktoren, wie Ozon, ultraviolettem Licht und Allergenen auf den vorderen Augenabschnitt.\\u000a \\u000a \\u000a Menschliche Tränenflüssigkeit wurde mit Ozon inkubiert oder mit UV-Licht bestrahlt bzw. mit Allergenen versetzt. Die Analyse\\u000a mittels

J. Horwath-Winter; O. Schmut

2001-01-01

132

Akanthamöben bei beschwerdefreien Kontaktlinsenträgern? Untersuchung von Behältern  

Microsoft Academic Search

\\u000a Zusammenfassung\\u000a Hintergrund  Die Verwendung von Leitungswasser bei der Kontaktlinsenhandhabung gilt als Risikofaktor für eine Infektion mit Akanthamöben\\u000a [10, 17]. Es ist anzunehmen, dass der kontaminierte Aufbewahrungsbehälter häufig der auslösende Faktor für eine Infektion\\u000a des Auges ist [9]. Welches Risiko geht jener österreichische Augenarzt ein, der Leitungswasser zur Hartlinsenspülung und Behälterreinigung\\u000a miteinbezieht, und worin liegen die Vorteile von Leitungswasser?\\u000a \\u000a \\u000a \\u000a Patienten und Methode  150

K. Hitil; C. Faschinger; E. M. Haller-Schober; H. Hiti; J. Walochnik; H. Aspöck

2000-01-01

133

Die Situation der Angehörigen von Strahlentherapiepatienten  

Microsoft Academic Search

\\u000a \\u000a Hintergrund und Ziel:\\u000a   Untersuchungen haben gezeigt, dass die Angehörigen aus Patientensicht einen sehr hohen Stellenwert bei der Entscheidungsfindung\\u000a zur Durchführung medizinischer Behandlungsmaßnahmen einnehmen. Durch eine gezielte Befragung der nächsten Angehörigen von\\u000a Strahlentherapiepatienten wurde daher die Situation dieser Personengruppe im Sinne einer Bestandsaufnahme untersucht.\\u000a \\u000a \\u000a \\u000a \\u000a \\u000a Befragte Stichprobe und Methodik:\\u000a   Mittels eines neu entwickelten Fragebogens wurden in einem definierten Erhebungszeitraum von 6 Wochen

Felix Momm; Sabine Lingg; Carola Xander; Sonja Adebahr; Anca-Ligia Grosu; Gerhild Becker

2010-01-01

134

Fundamentals of quantitative research  

Microsoft Academic Search

The main purpose of this article is to introduce some important fundamental concepts of quantitative research to readers especially novice researchers. It comprises types of research, definitions of quantitative research, different types and assumptions of quantitative research, when to use and not to use quantitative methods, advantages, common approaches and samples of quantitative research, and common misconceptions. Besides, a set

Suphat Sukamolson

135

Mutations of von Willebrand factor gene in families with von Willebrand disease in the Aland Islands  

SciTech Connect

Patients with von Willebrand disease in four families in the Aland Islands, including the original family that was described in 1926 by the Finnish physician von Willebrand, were screened for mutations in the Swedish hot-spot' regions (exons 18, 28, 32, 43, and 45) of the von Willebrand factor gene. One cytosine deletion in exon 18 was detected in each of these families. Linkage analysis and genealogical studies suggest that the deletion present in these four families probably has an origin in common with the mutations in the Swedish patients. Apart from the deletion in exon 18, two close transitions (G [yields] A at S1263 and C [yields] T at P1266) in exon 28 on the same chromosome were identified in one individual who married into the original family and in his two children. The transitions could be due to a recombination between the von Willebrand factor gene and its pseudogene. 24 refs., 3 figs., 3 tabs.

Zhang, Z.P.; Blombaeck, M.; Anvret, M. (Karolinska Hospital, Stockholm (Sweden)); Nyman, D. (Aland Central Hospital (France))

1993-09-01

136

Rehabilitation von Patienten mit extrem atrophierten Kiefern mittels Implantatinsertion nach Augmentation von autologem Beckenkammknochen  

Microsoft Academic Search

Zusammenfassung  Das Ziel der vorliegenden Untersuchung war die Erfolgskontrolle von Implantationen in mit Beckenkammknochen augmentierte Kieferregionen.\\u000a Die retrospektive Untersuchung betraf 599 Implantationen, welche in den Jahren 1991 bis 2005 bei 110 Patienten (36 männliche\\u000a und 74 weibliche Patienten mit einem Durchschnittsalter von 50,5 Jahren) in der Klinik für Mund-Kiefer-Gesichtschirurgie der\\u000a Charité, Berlin vorgenommen wurden. Vor der Implantatinsertion wurden unterschiedliche Operationstechniken zur

Susanne Heberer; Michael Hohl; Wiebke Semper; Jürgen Willer; Katja Nelson

2008-01-01

137

Zulässigkeit von Online-Marketing auf der Basis von Erkenntnissen aus sozialen Netzwerken  

Microsoft Academic Search

\\u000a Soziale Netzwerke und sonstige offene Internetquellen sind für Werbetreibende von besonderem Interesse. Sie enthalten zum\\u000a einen vielfältige Informationen, die über Vorlieben und Interessen der Nutzer sehr genaue Auskunft geben und sowohl einzeln\\u000a als auch im Wege der Verknüpfung eine individuell zugeschnittene Werbeansprache ermöglichen. Zum anderen kann, da sie der\\u000a Nutzer selbst eingegeben hat, von der Richtigkeit der meisten Daten ausgegangen

Ralf B. Abel

138

Qualitätserwartungen und ethischer Anspruch bei der Lektüre von Blogs und von Tageszeitungen  

Microsoft Academic Search

Zusammenfassung  Mediennutzerinnen und Mediennutzer lesen neben klassischen journalistischen Erzeugnissen zunehmend von Usern publizierte Texte\\u000a im Internet wie zum Beispiel in Weblogs. Wie orientieren sich Rezipienten in diesem Angebot, wie beurteilen sie die Qualität\\u000a und welche medienethischen Standards legen sie bei der Lektüre von Weblogs im Gegensatz zu Zeitungsartikeln an? Diesen Fragen\\u000a widmen sich zwei empirische Studien. In einer Befragung beurteilten 702

Sabine Trepte; Leonard Reinecke; Katharina-Maria Behr

2008-01-01

139

Aberrationen höherer Ordnung nach Implantation von asphärischen und sphärischen Intraokularlinsen in Abhängigkeit von der Pupillenweite  

Microsoft Academic Search

ZusammenfassungHintergrundDurch die Implantation von asphärischen Intraokularlinsen (IOLs) soll die positiv sphärische Aberration der Kornea ausgeglichen werden. Ziel der Untersuchung war der intraindividuelle Vergleich von Aberrationen höherer Ordnung nach der Implantation einer asphärischen und einer sphärischen IOL.Patienten und MethodenBei 10 Patienten wurden randomisiert jeweils eine asphärische sowie eine sphärische IOL nach Kataraktextraktion implantiert. Nach 3 Monaten wurden Wellenfrontmessungen in Mydriasis mit einem

T. Kasper; J. Bühren; T. Kohnen

2005-01-01

140

Visceral artery aneurysms in Von Recklinghausen's neurofibromatosis  

Microsoft Academic Search

We report the case of a patient with Von Recklinghausen's neurofibromatosis in whom two visceral artery aneurysms were diagnosed: a 4 cm aneurysm originating from the common hepatic artery and a smaller aneurysm originating from the superior mesenteric artery. The hepatic artery aneurysm underwent successful embolization. Because of the patient's poor general condition, the superior mesenteric aneurysm was considered inoperable

Réda Hassen-Khodja; Serge Declemy; Michel Batt; Jérôme Castanet; Christophe Perrin; Jean-Paul Ortonne; Pierre Le Bas

1997-01-01

141

J. W. von Goethe und die Entomologie  

Microsoft Academic Search

J. W. von Goethe is famous for his Faust I and II, where we find wonderful verses about various insects (very interesting for entomologists); he investigated the anatomy, behaviour and the way of life of some moths (posthum published by KUHN, 1987) as well and he has known the biology of the army worms {Lycoria militaris Nowicki) and some interesting

J. W. von Goethe; Wolfgang Schedl

142

Heinz von Foerster and the Mansfield Amendment  

Microsoft Academic Search

Heinz von Foerster was the founder and director of the Biological Computer Laboratory (BCL) at the University of Illinois in Urbana-Champaign. BCL existed from 1957 to 1976.In 1976 Heinz retired and moved to California. One revealing story about Heinz and the Biological Computer Laboratory concerns the Mansfield Amendment, which led to the closing of BCL. I was a graduate student

Stuart Umpleby

143

Alexander von Humboldt: a revolutionary explorer.  

PubMed

After he returned from his five-year expedition to the New World, Alexander von Humboldt promoted himself as a Romantic explorer. Although this image pervades British perceptions, political movements have fashioned different heroic versions of Humboldt in Germany and South America. PMID:18276009

Fara, Patricia

2008-02-13

144

Von Economo Neurons in the Elephant Brain  

Microsoft Academic Search

Von Economo neurons (VENs), previously found in humans, all of the great ape species, and four cetacean species, are also present in African and Indian elephants. The VENs in the elephant are primarily found in similar locations to those in the other species. They are most abundant in the frontoinsular cortex (area FI) and are also present at lower density

Atiya Y. Hakeem; Chet C. Sherwood; Christopher J. Bonar; Camilla Butti; Patrick R. Hof; John M. Allman

2009-01-01

145

Primärversorgung von psychischen und psychosomatischen Patienten  

Microsoft Academic Search

Zusammenfassung  Der Erstkontakt psychisch und psychosomatisch Erkrankter findet im deutschen Gesundheitssystem meist unter der Präsentation von körperlichen Störungen in einer Hausarztpraxis statt. Aufgrund der speziellen äußeren Strukturen der hausärztlichen Praxisführung und einem besonders dem Hausarzt eigenen pragmatischen lösungsorientierten Umgang mit seinen Patienten begegnet er den Patienten mit psychischen und psychosomatischen Krankheiten in anderer Weise, als es der Psychotherapeut für adäquat hält.

J. Parpart; W. Schneider

2006-01-01

146

Carl Von Clausewitz: Two Letters on Strategy.  

National Technical Information Service (NTIS)

This edition of Carl von Clausewitz's Two Letters on Strategy was made possible by the Army War College Foundation and by the Art of War Colloquium of the Army War College, which sponsors the volume as part of its program of republishing military classics...

D. Moran P. Paret

1984-01-01

147

Bestimmungsgründe von Flächenausweitungsplänen in der Berglandwirtschaft Österreichs  

Microsoft Academic Search

1. Einleitung Das allgemeine Ziel des vorliegenden Beitrages ist es, durch die Analyse von einzelbetrieblichen Befragungsdaten aus dem österreichischen Berggebiet empirische Befunde zur Debatte über den Strukturwandel in der Landwirtschaft bei- zutragen. Die Befragung erfolgte im Jahr 2000 im Rahmen eines umfangreichen Forschungsprojektes der Universität für Bodenkultur Wien zum Strukturwandel im österreichi- schen Alpenraum (siehe Anmerkung 1). Es handelt sich

S. Vogel; M. F. Hofreither; W. Schneeberger; F. Weiß

2004-01-01

148

Strategien bei der Veröffentlichung von Forschungsdaten  

Microsoft Academic Search

Forschungsdaten liegen in Abhängigkeit der Disziplinen in vielfältigen Formen und Formaten vor. Sie sind in allen Disziplinen Teil des wissenschaftlichen Erkenntnisprozesses. Als digitales Informationsobjekt sind sie komplex und bislang wenig untersucht. Mit den Möglichkeiten neuer Informationstechnologien werden in den letzten Jahren neue Wege in der Publikation von Forschungsdaten beschritten. Mit Blick auf die Naturwissenschaften werden im Folgenden drei Publikationsmodelle beschrieben:

Sünje Dallmeier-Tiessen

2011-01-01

149

Die Entspannung von Bedürfnissen durch Ersatzhandlungen  

Microsoft Academic Search

Zusammenfassung  \\u000a \\u000a \\u000a \\u000a 1. \\u000a \\u000a Die Wiederaufnahme einer unterbrochenen Handlung kann nach einer zweiten Handlung unterbleiben, wenn diese zweite Handlung\\u000a eine gewisse \\\\:Ahnlichkeit mit der ersten hat.\\u000a \\u000a \\u000a \\u000a \\u000a 2. \\u000a \\u000a Der \\\\ldErsatzwert\\\\rd einer solchen Ersatzhandlung h\\\\:angt von dem Grad derinhaltlichen Verwandtschaft von Grund- und Ersatzhandlung ab. Ausschlaggebend f\\\\:ur die inhaltliche Verwandtschaft ist nicht die \\\\:au\\\\sBere \\\\:Ahnlichkeit\\u000a der Aufgabe oder des Zielgegenstandes, sondern vor allem die

Käte Lissner

1933-01-01

150

[Duodenal somatostatinomas associated with von Recklinghausen disease].  

PubMed

A case of von Recklinghausen's disease with double somatostatin producing neuroendocrine tumour of the ampulla and duodenum is reported. A search of the world's literature revealed 28 patients with immunohistologically proven duodenal somatostatinoma associated with type I neurofibromatosis. These tumours are seldom associated with a recognizable "somatostatin syndrome", but often present with obstructive jaundice, duodenal obstruction, weight loss or gastrointestinal bleeding. Histologically, psammoma bodies are frequently encountered in the glandular lumina of duodenal somatostatinomas (66%), whereas their presence in other neuroendocrine tumours of the gastrointestinal tract is very rare. Metastatization is rare (27%) and mainly confined to lymph nodes (88%). In the world literature duodenal somatostatinoma is associated with von Recklinghausen's disease in 50%. PMID:9888169

Blaser, A; Vajda, P; Rosset, P

1998-12-12

151

Einschlußkörper in den Epidermiszellen von Chlorophytum comosum  

Microsoft Academic Search

Zusammenfassung Iu den Epidermiszelien vonChlorophytum cornosum (und auchChlorophytum elatum) kommen in den Vakuolen Kristalldrusen vor. deren chemische Natur noch nicht eindeutig festgestellt werden konnte. Da neben den Drusen auch noch lebhaft bewegliche Cytoplasmaballen. die als x-Bodies angesehen werden und auch fibrilläre Eiweißspindeln beobachtet wurden, wird angenommen, daß die erwähnten Kristalldrusen ebenfalls Stoffwechselprodukte virusinfizierter Zellen sind. Auch polsterartige Kallosebildungen an den

Griseldis Kenda

1961-01-01

152

Das gesellschaftliche Engagement von vermögenden Personen  

Microsoft Academic Search

In Deutschland gibt es 798.000 Millionäre (2006) (Capgemini und Merrill Lynch 2007); 122 Einzelpersonen oder Familien verfügen\\u000a über ein Vermögen von mindestens einer Milliarde Euro (Manager Magazin Spezial 2007). Die reichsten 10 % der Bevölkerung besitzen\\u000a annähernd 60 % und das oberste Prozent mehr als 20 % des gesamten Vermögens (vgl. Grabka und Frick 2007; vgl. auch SPD-Bundestagsfraktion\\u000a 2007). Diese

Martina Kischel

153

Konfigurierbare modulare Vorgehensmodelle zur Entwicklung von Dienstleistungen  

Microsoft Academic Search

\\u000a Vorgehensmodelle sind neben den Service Engineering-Methoden und der Werkzeugunterstützung ein wichtiger Bestandteil der systematischen\\u000a Entwicklung von Dienstleistungen. Sie beschreiben, welche Tätigkeiten in welcher Reihenfolge durchzuführen sind, legen Zuständigkeiten\\u000a für diese Tätigkeiten und deren Ergebnisse fest und geben Hinweise, wie die Tätigkeiten durchgeführt werden sollen. Sie bilden\\u000a somit die Grundlage für das Projekt- und Qualitätsmanagement in Entwicklungsprojekten.

Oliver Strauß; Tek-Seng The; Anette Weisbecker

154

Friedrich August von Ammon (1799–1861)  

Microsoft Academic Search

As this year marks the 200th anniversary of the birth of Friedrich August von Ammon (1799–1861), it presents an opportunity\\u000a to recall and celebrate Ammon's life and his many contributions that helped shape both ophthalmology and plastic surgery into\\u000a independent specialties. Some 250 years after Georg Bartisch, Ammon reestablished Dresden as a major center of ophthalmology,\\u000a through the creation of

David M. Reifler

1999-01-01

155

Zündung von Propan\\/Luft-Gemischen durch Büschelentladungen  

Microsoft Academic Search

Zusammenfassung An einer Versuchsanordnung, deren Abmessungen etwa denen entsprechen, die bei elektrostatisch aufgeladenen Wolken in geschlossenen Räumen vorliegen können, wird die Zündfähigkeit von Büschelentladungen im Propan\\/Luft-gemisch mit 5,0% Propan untersucht. Liegt die Elektrode, von der die Büschel ausgehen, am negativen Pol der Spannung, sind der Strom und die Spannung, bei denen die Explosion entsteht, größer, als wenn die Büschel von

Erhart Heidelberg

1959-01-01

156

Acquired von Willebrand syndrome in multiple myeloma.  

PubMed

Acquired von Willebrand syndrome (AvWS) is an uncommon complication of multiple myeloma (MM), and it is believed to be connected with paraprotein. The aim of this study was to determine the incidence of AvWS in patients with MM, and estimate the role of paraprotein in its occurrence. The study included 40 patients with MM. The plasma level of paraprotein, platelet adhesion on glass pearls, plasma von Willebrand factor antigen concentration, and ristocetin-induced platelet aggregation (RIPA) were measured initially. Absence of RIPA was found in six patients with MM (15%); however, all six of them had normal levels of von Willebrand factor antigen. Paraprotein was isolated from the serum of these patients. Platelet aggregation was measured in six healthy donors before and after addition of the isolated paraprotein. RIPA was significantly decreased in healthy donors in the presence of paraprotein (P<0·001). The same test was repeated with added human immunoglobulins for intravenous use without any change in RIPA. A significant negative correlation between plasma paraprotein level and RIPA was found (P<0·001). These investigations have shown that paraprotein is associated with AvWS in patients with MM. PMID:21756536

Djunic, Irena; Elezovic, Ivo; Ilic, Vesna; Tomin, Dragica; Suvajdzic-Vukovic, Nada; Bila, Jelena; Antic, Darko; Vidovic, Ana; Milosevic-Jovcic, Nadezda

2011-07-01

157

Konstante Proportionen von Enzymen des Embden-Meyerhof-Weges im menschlichen Myometrium  

Microsoft Academic Search

An verschiedenen Muskeltypen einschließlich des Myometriums wurden die Aktivitäten von Enzymen des energieliefernden Stoffwechsels bestimmt und die Ergebnisse in Form von Aktivitätsmustern wiedergegeben.

Wilfried Luh; Eberhard Henkel

1964-01-01

158

Ein automatisches Planimeter zur Auswertung von Streifenblatt-Chromatogrammen (optisches Nachlaufsystem)  

Microsoft Academic Search

Es wird ein automatisches Planimeter zur Auswertung von Streifenblatt-Chromatogrammen (optisches Nachlaufsystem) beschrieben, das mit Standardabweichungen von 0,4% oder besser reproduzierbare Werte liefert.

O. Weber

1963-01-01

159

Laboratory testing for von Willebrand disease: contribution of multimer analysis to diagnosis and classification.  

PubMed

The stepwise diagnosis of von Willebrand disease (vWD) includes patient and family history, screening procedures (bleeding time, filter tests, platelet counts, activated partial thromboplastin time [aPTT]), confirmatory tests (von Willebrand factor [vWF]:antigen [Ag], vWF:ristocetin cofactor activity assay [RCo], vWF:collagen-binding test [CB], ristocetin-induced platelet agglutination [RIPA], and factor [F] VIII:coagulant activity [C]) and tests for final classification (multimeric analysis, vWF:factor VIII binding, and platelet vWF). Accumulating knowledge of the different clinical phenotypes and the pathophysiological basis of the disease have been translated into a classification that differentiates between quantitative and qualitative defects by means of quantitative and functional parameters and by analyzing the electrophoretic pattern of vWF multimers, but without inclusion of the genotype. Recently, it has been shown that with a sensitive method of multimer analysis, a > 90% genotype-phenotype relation may be achieved in the near future. PMID:16862525

Budde, Ulrich; Pieconka, Antje; Will, Kirsten; Schneppenheim, Reinhard

2006-07-01

160

CHARAKTERISTIKA VON TÜRKISCHEN DIABETIKERN IN DEUTSCHLAND: EIN VERGLEICH MIT DATEN VON PATIENTEN IN DER TÜRKEI  

Microsoft Academic Search

Einleitung: Mit Ausnahme einiger regionaler oder ethnischer Unterschiede zeigt die Häufigkeit von Diabetes mellitus fast weltweit eine steigende Tendenz. In den Ländern im östlichen Mittel- meerraum werden Häufigkeiten bis 14% berichtet. Eine besonders hohe Diabetespräva- lenz wurde unter asiatischen Migranten in England und Schweden festgestellt, wo eine Zunahme um das 3-4 fache gegenüber der einheimischen Bevölkerung beobachtet wurde. Neben ethnischer

Y. Gökce; N. Soydan; M. Erkal; A. Kececi; A. Gediz; R. G. Bretzel

161

Die Auxosporenbildung von Surirella ovata und die Lagebeziehungen von Mutterzellen und Erstlingszellen bei Diatomeen  

Microsoft Academic Search

Zusammenfassung Eine Übersicht über die verschiedenen konstitutionell festgelegten Lagebeziehungen der Achsen von Mutterzellen und Auxosporen bzw. Erstlingszellen ergibt einige ursächliche Deutungsmöglichkeiten (mechanische Auslösung, Stellung zum Substrat); es ist zu erwarten, daß ein größere Tatsachenmaterial die Zusammenhänge besser erkennen lassen wird. Dies gilt auch für die Fragestellung, warum die 1. Epitheka in einer bestimmten Lage gebildet wird.

Lothar Geitler

1963-01-01

162

Victor or Villain? Wernher von Braun and the Space Race  

ERIC Educational Resources Information Center

|Set during the Cold War and space race, this historical role-play focuses on Wernher von Braun's involvement in and culpability for the use of slave laborers to produce V-2 rockets for Nazi Germany. Students will grapple with two central questions. Should von Braun have been allowed to emigrate to the United States given his affiliation with the…

O'Brien, Jason L.; Sears, Christine E.

2011-01-01

163

Die medikamentöse Prophylaxe nach elektronischer Kardioversion von chronischem Vorhofflimmern  

Microsoft Academic Search

Zusammenfassung Vorhofflimmern (VHF) ist die häufigste aller Herzrhythmusstörungen. Trotz einer großen Zahl klinischer Studien sowie einer Vielzahl von Publikationen in den vergangenen Jahrzehnten wird die Therapie des VHF in der klinischen Routine wie auch in wissenschaftlichen Untersuchungen kontrovers diskutiert. Die vorliegende Studie soll folgende wesentliche Fragen beantworten: 1. Wie hoch ist die spontane Rezidivquote von VHF im Langzeitverlauf nach Kardioversion?

T. Fetsch; G. Burschel; G. Breithardt; R. Engberding; H.-P. Koch; J. Lukl; H.-J. Trappe; N. Treese

1999-01-01

164

Anesthesia and von Hippel-Lindau disease associated with pheochromocytoma  

Microsoft Academic Search

Von Hippel-Lindau disease is char­ acterized by the association of retinal angiomatosis with cerebellar hemangiomas. But the disease may manifest a variety of distinct lesions, more than 25 of which have been identified. Von Rippel-Lindau disease described here was associated with pheochromocytoma. We report on the rare case of anesthesia and discuss the potential anesthetic problems. Case Report The patient,

Yuko Hoshino; Hidefumi Obara; Katsuya Mikawa; Seizo Iwai

1987-01-01

165

Experimentelle Beiträge zur Anwendung von Hyaluronidase in der Aerosoltherapie  

Microsoft Academic Search

Zusammenfassung Nach der Anwendung von hyaluronidasehaltigem Aerosol lassen sich inhalierte Streptokokken längere Zeit in ungewöhnlich großer Zahl in der Lunge von Meerschweinchen nachweisen. Die Hyaluronidaseinhalation bleibt ohne Folgen, wenn sie mit der Inhalation eines geeigneten antibakteriellen Arzneimittels gekoppelt wird. Diese antibakteriellen Mittel sollen keine hohe Spezifität gegen einzelne Erreger haben, sie müssen vielmehr ein möglichst breites Wirkungsspektrum haben. Wenn man

Theo Halbeisen; Hans Friebel; Anselm Basold

1952-01-01

166

Differenzierung von Marken durch Neuromarketing am Beispiel der Tourismusbranche  

Microsoft Academic Search

Empirische Studien belegen, dass die differenzierende und emotionalisierende Wirkung starker Marken einen erheblichen Einfluss auf betriebswirtschaftliche Unternehmens-Kennzahlen wie auch psychologische Effekte auf Kunden- und Mitarbeiterseite hat. Trotz des hohen Potenzials von Marken sind diese jedoch in vielen Branchen noch relativ schwach und undifferenziert. Am Beispiel der Tourismusbranche wird aufgezeigt, wie mit Hilfe von Methoden des Neuromarketings das differenzierende und emotionalisierende

Ingo Markgraf; David Scheffer

2011-01-01

167

Die Resektion von heterotopen Ossifikationen des Hüftgelenks Querschnittgelähmter  

Microsoft Academic Search

Zusammenfassung Operationsziel Wiederherstellung der Hüftgelenkbeweglichkeit. Verringerung der Spastik. Verminderung oder Beseitigung von Schmerzen. Indikationen Völlige oder die Funktion erheblich behindernde Einsteifung des Hüftgelenks. Kontraindikationen Noch nicht abgeschlossene Knochenneubildung. Nachweis einer hohen Umbaurate (Szintigraphie, alkalische Phosphatase, Röntgenbild). Akuter Infekt, insbesondere Harnweginfektionen bei Blasenlähmung. Fehlende funktionelle Einschränkung. Operationstechnik Hautschnitt von der Spina iliaca anterior superior entlang dem Musculus sartorius. Ablösen des Musculus

Rainer Abel; Thomas Meiners; Hans Jürgen Gerner

2002-01-01

168

Die Dosierung von Dexamethason und Triamcinolon bei Bronchialasthma  

Microsoft Academic Search

Zusammenfassung Die Wirksamkeit zweier neuerer Corticosteroid-Derivate, Triamcinolon und Dexamethason, wurde an 29 Patienten mit chronischem, schwerem Bronchialasthma geprüft. Ihre Erhaltungsdosis wurde mit der Erhaltungsdosis von Prednison am gleichen Patienten verglichen. Das Dosisverhältnis Prednison-Dexamethason betrug im Mittel 5,4, das von Prednison-Triamcinolon 1:1,6.

E. Stresemann

1959-01-01

169

Die Bedeutung der Arbeiten Albrecht von Graefes für die Gesichtsfeldprüfung  

Microsoft Academic Search

von Graefe's paper „Über die Untersuchung des Gesichtsfeldes bei amblyopischen Affektionen“ initiated the systematic examination of the visual field in ophthalmology. He insisted that the objective changes recorded by the ophthalmoscope should be related to the resulting functional disturbances. His treatise is of fundamental importance with its wealth of keen observations and new methods. Von Graefe made a distinction between

Heinrich Harms

1971-01-01

170

Quantitative trait loci in Drosophila  

Microsoft Academic Search

Phenotypic variation for quantitative traits results from the simultaneous segregation of alleles at multiple quantitative trait loci. Understanding the genetic architecture of quantitative traits begins with mapping quantitative trait loci to broad genomic regions and ends with the molecular definition of quantitative trait loci alleles. This has been accomplished for some quantitative trait loci in Drosophila. Drosophila quantitative trait loci

Trudy F. C. Mackay

2001-01-01

171

Congenital von Willebrand's disease and clinical hypothyroidism.  

PubMed

Data from case reports and systematic reviews suggest an association of Hypothyroidism and Acquired von Willebrand's syndrome. It is not known if congenital von Willebrand's disease is associated with hypothyroidism in a similar way. The aim of this study was to identify the association of congenital von Willebrand's disease (VWD) with clinical hypothyroidism. A total of 350 cases of congenital VWD were initially screened from our institution database from 1985 to 2010. A careful review of patient records was carried out to see if patients truly had congenital VWD and coexisting clinical hypothyroidism. Patients with uncertain diagnoses or other bleeding disorders were excluded, leading to 197 patients remaining in the final sample. A random age- and sex-matched parallel control group was also obtained from the hospital database. Of 197 patients (mean age 43.8 ± 17.5 years, women 72%) of congenital VWD, 32/197 (16%) were diagnosed with clinical hypothyroidism, while only 11/197 (5.6%) of the matched controls were clinically hypothyroid. Univariate and multivariate analysis demonstrated that VWD was an independent predictor of developing clinical hypothyroidism (OR 3.45; 95% CI 1.65-7.22, P = 0.001). The proportion of patients diagnosed with clinical hypothyroidism was more in the VWD group (P < 0.0001). Our analysis shows a strong association of clinical hypothyroidism in patients with congenital VWD, but future studies will be required to delineate a pathological mechanism. In our opinion, clinicians should consider checking thyroid function in the newly diagnosed and established cases of congenital VWD. PMID:23171382

Hassan, S; Qureshi, W; Donthireddy, V; Kuriakose, P

2012-11-22

172

Von Recklinghausen's disease with urogenital manifestation.  

PubMed

Neurofibromatosis or Von Recklinghausen's disease is a rare disease that affects the urogenital system in its visceral form. We report on one case where the patient had a recurring mass located in the vesicouterine space that caused irritative urinary symptoms, which was confirmed as uterine cervix neurofibroma following surgery and immunohistochemical study. We stress the importance of a wide resection of such tumors and the need for long-term follow-up due to the high recurrence index and the risk of malignant transformation. PMID:15877836

Nunes, Thiago F; Costa, Renato P; Navarro, Fabio C

173

[Albrecht von Haller. An illustrious ancestor].  

PubMed

Albrecht von Haller (1708-1777) was one of the most famous and important men of the eighteenth century. His achievements make him comparable with Lessing and Newton. In Blumenbach's opinion he was one of the enlightenment's greatest thinkers in both versatility and depth. He contributed significantly to developments in medicine, physiology, botany, pharmacology, theology, literature, editing, chronicles, biography, geography, and during his later years in Switzerland jurisprudence and agrarian reform. On the occasion of the 300th anniversary of his birth, important scientific landmarks in his life are described, with special attention to his achievements in the fields of anatomy, physiology, surgery, and experimental research. PMID:18661596

Peiper, H-J

2008-05-01

174

Key contributors: Ernst von Glasersfeld's radical constructivism  

NASA Astrophysics Data System (ADS)

This article reviews the significance of the contributions of Ernst von Glasersfeld to research in science education, especially through his theoretical contributions on radical constructivism. As a field shaper, Glasersfeld's subversive ideas catalyzed debate in the science education community and fuelled transformation of many facets including research methods, ways of thinking about teaching and learning, curriculum, and science teacher education. Perturbations emanating from the debates on constructivism forged new pathways that led to the development and use of many of the sociocultural frameworks employed by authors in Cultural Studies of Science Education.

Tobin, Kenneth

2007-07-01

175

Cytogenetische Untersuchungen an Taraxacum im Raume von Wien. II. Hybriden zwischen T. officinale und T. palustre  

Microsoft Academic Search

Zusammenfassung Die Auswertung von Kreuzungsexperimenten zeigt, daß beiTaraxacum in einem weit höheren Maß, als auf Grund der in dieser Gattung so weit verbreiteten apomiktischen Fortpflanzung ursprünglich anzunehmen war, mit Artbastarden gerechnet werden muß. Die Hybriden treten nioht nur bei Kreuzungen von — im Raume von Wien häufigen — diploiden Pflanzen auf, sondern auch bei Kreuzungen von diploiden Pflanzen mit tetraploiden,

Dietrich Fürnkranz

1961-01-01

176

Von Willebrand disease: pathogenesis and management.  

PubMed

Recent studies have suggested a unifying pathophysiological concept to explain the underlying defects of von Willebrand factor (VWF) causing von Willebrand disease (VWD) and have highlighted the relevance of simple VWF related activities in producing a useful diagnosis. A standardized bleeding history condensed into a final bleeding score and few widely available laboratory tests, such as VWF ristocetin cofactor activity, VWF antigen and factor VIII (FVIII), in the index case and in his/her relatives are of critical importance. Ristocetin-induced platelet aggregation (RIPA) should also be tested. Trial with desmopressin should be carried out in patients, except those with virtual absence of VWF or with increased RIPA. Desmopressin should be used in all responsive patients as first choice. Substitutive treatment with VWF/FVIII containing products should be used in unresponsive patients, in those with heightened response to desmopressin or in those undergoing interventions requiring good hemostasis for more than 3-5 days. Special consideration should be deserved to the treatment of menorrhagia and parturition. PMID:23452742

Rodeghiero, Francesco

2013-01-01

177

Translational medicine advances in von Willebrand disease.  

PubMed

Following the recognition of von Willebrand disease (VWD) in 1926 and the cloning of the gene for von Willebrand factor (VWF) in 1985, significant advances have been made in our fundamental knowledge of both the disease and the protein. Some of this new knowledge has also begun to impact the clinical management of VWD. First, the progressive increase in our understanding of the molecular genetic basis of VWD has resulted in rational applications of molecular testing to complement the current range of phenotypic tests for VWD. These molecular genetic strategies are most effectively directed at the prenatal diagnosis of type 3 VWD and confirmatory testing for types 2B and 2N disease. In contrast, the use of molecular testing to clarify the diagnosis of type 1 VWD is of marginal benefit, at best. In terms of VWD therapies, a new recombinant VWF concentrate has recently completed successful clinical trials and is now awaiting more widespread application. There have even been some preclinical successes with VWF gene transfer although the clinical rationale for this therapeutic strategy needs careful consideration. Much more remains to be learnt about the biology of VWF and further translational advances for the enhancement of VWD care will inevitably be realized. PMID:23809112

Lillicrap, D

2013-06-01

178

Von Willebrand Factor, Angiodysplasia and Angiogenesis  

PubMed Central

The large multimeric glycoprotein Von Willebrand factor (VWF) is best known for its role in haemostasis; however in recent years other functions of VWF have been identified, indicating that this protein is involved in multiple vascular processes. We recently described a new role for VWF in controlling angiogenesis, which may have significant clinical implications for patients with Von Willebrand disease (VWD), a genetic or acquired condition caused by the deficiency or dysfunction of VWF. VWD can be associated with angiodysplasia, a condition of degenerative blood vessels often present in the gastrointestinal tract, linked to dysregulated angiogenesis. Angiodysplasia can cause severe intractable bleeding, often refractory to conventional VWD treatments. In this review we summarise the evidence showing that VWF controls angiogenesis, and review the angiogenic pathways which have been implicated in this process. We discuss the possible mechanisms though which VWF regulates angiopoietin-2 (Ang-2) and integrin ?v?3, leading to signalling through vascular endothelial growth factor receptor-2 (VEGFR2), one of the most potent activators of angiogenesis. We also review the evidence that links VWF with angiodysplasia, and how the newly identified function of VWF in controlling angiogenesis may pave the way for the development of novel therapies for the treatment of angiodysplasia in congenital VWD and in acquired conditions such as Heyde syndrome.

Randi, Anna M.; Laffan, Mike A.; Starke, Richard D.

2013-01-01

179

Clarifying the link between von Neumann and thermodynamic entropies  

NASA Astrophysics Data System (ADS)

The state of a quantum system being described by a density operator ?, quantum statistical mechanics calls the quantity - kTr( ?ln ?), introduced by von Neumann, its von Neumann or statistical entropy. A 1999 Shenker's paper initiated a debate about its link with the entropy of phenomenological thermodynamics. Referring to Gibbs's and von Neumann's founding texts, we replace von Neumann's 1932 contribution in its historical context, after Gibbs's 1902 treatise and before the creation of the information entropy concept, which places boundaries into the debate. Reexamining von Neumann's reasoning, we stress that the part of his reasoning implied in the debate mainly uses thermodynamics, not quantum mechanics, and identify two implicit postulates. We thoroughly examine Shenker's and ensuing papers, insisting upon the presence of open thermodynamical subsystems, imposing us the use of the chemical potential concept. We briefly mention Landau's approach to the quantum entropy. On the whole, it is shown that von Neumann's viewpoint is right, and why Shenker's claim that von Neumann entropy "is not the quantum-mechanical correlate of thermodynamic entropy" can't be retained.

Deville, Alain; Deville, Yannick

2013-01-01

180

On the mapping connecting the cylindrical nonlinear von Neumann equation with the standard von Neumann equation  

NASA Astrophysics Data System (ADS)

The Wigner transformation is used to define the quasidistribution (Wigner function) associated with the wave function of the cylindrical nonlinear Schrödinger equation (CNLSE) in a way similar to that of the standard nonlinear Schrödinger equation (NLSE). The phase-space equation, governing the evolution of such quasidistribution, is a sort of nonlinear von Neumann equation (NLvNE), called here the "cylindrical nonlinear von Neumann equation" (CNLvNE). Furthermore, the phase-space transformations, connecting the Wigner function and the NLvNE with the "cylindrical Wigner function" and the CNLvNE, are found by extending the configuration space transformations that connect the NLSE and the CNLSE. Some examples of phase-space soliton solutions are given analytically and evaluated numerically.

Fedele, R.; de Nicola, S.; Jovanovi?, D.; Grecu, D.; Visinescu, A.

2010-08-01

181

Augmentation von Patellafrakturen und Patellarsehnenrupturen mittels McLaughlin-Cerclage  

Microsoft Academic Search

Zusammenfassung  Die Augmentation von Patellafrakturen und Patellarsehenrupturen wurde erstmals 1946 von H.F. McLaughlin beschrieben. Wir führten\\u000a eine retrospektive Analyse der Ergebnisse von 14 Patienten durch, die in den Jahren 1999–2004 wegen einer Patellarsehenruptur\\u000a oder Patellafraktur an unserer Klinik mit einer McLaughlin-Cerclage versorgt worden waren. Anhand der Röntgenbilder wurde\\u000a die Insall-Salvati-Ratio (ISR) vor und nach Materialentfernung sowie auf der Gegenseite bestimmt, zudem das

A. Ahrberg; C. Josten

2007-01-01

182

Von Neumann's growth model: Statistical mechanics and biological applications  

NASA Astrophysics Data System (ADS)

We review recent work on the statistical mechanics of Von Neumann's growth model and discuss its application to cellular metabolic networks. In this context, we present a detailed analysis of the physiological scenario underlying optimality à la Von Neumann in the metabolism of the bacterium E. coli, showing that optimal solutions are characterized by a considerable microscopic flexibility accompanied by a robust emergent picture for the key physiological functions. This suggests that the ideas behind optimal economic growth in Von Neumann's model can be helpful in uncovering functional organization principles of cell energetics.

De Martino, A.; Marinari, E.; Romualdi, A.

2012-09-01

183

Möglichkeiten der gezielten Bekämpfung von Pyrethroid-resistenten Rapsglanzkäferpopulationen – Ergebnisse von Ringversuchen mehrerer Bundesländer  

Microsoft Academic Search

Zusammenfassung  In den Jahren 2006 bis 2008 wurden in den Bundesländern Brandenburg, Sachsen, Sachsen-Anhalt und Thüringen Versuche zur Regulierung\\u000a von Pyrethroid-resistenten Rapsglanzkäferpopulationen mit neuen insektiziden Wirkstoffen durchgeführt. Der Auslöser für diese\\u000a Versuchsserien waren die hohen Ertragsverluste beim Winterraps in einigen Bundesländern im Jahr 2006. Diese waren die Folge\\u000a einer einseitigen Zulassungspraxis mit dem Schwerpunkt auf Pyrethroide der Klasse II. Es wurden Wirkstoffe

G. Schröder; B. Pölitz; C. Wolff; B. Krüger

2009-01-01

184

The two Vons: the World War I secret government investigation of Erich von Stroheim  

Microsoft Academic Search

:Research in U.S. government archives concerning World War I-era German espionage activities in the United States reveals a number of previously unknown surveillance files regarding film actor and director Erich von Stroheim. The essay describes the process through which these otherwise un-indexed files were discovered and reprints several of the key documents. Evidence indicates that Military Intelligence suspected a link

Elliot Einzig Porter

2010-01-01

185

The two Vons: the World War I secret government investigation of Erich von Stroheim  

Microsoft Academic Search

Research in U.S. government archives concerning World War I-era German espionage activities in the United States reveals a number of previously unknown surveillance files regarding film actor and director Erich von Stroheim. The essay describes the process through which these otherwise un-indexed files were discovered and reprints several of the key documents. Evidence indicates that Military Intelligence suspected a link

Elliot Einzig Porter

2010-01-01

186

Quantitative methods in archaeoseismology  

Microsoft Academic Search

Within the multidisciplinary field of archaeoseismology, quantitative methods have begun to be utilized more prevalently. This paper proposes a scheme of applying quantitative models to test the seismogenic hypothesis of observed damage and gives examples from field cases. The combination of 3D structural models of buildings or their remains based in part on phase shift laserscanner measurements combined with high-resolution

Klaus-G. Hinzen; Claus Fleischer; Sharon K. Reamer; Stephan Schreiber; Sven Schütte; Baris Yerli

2011-01-01

187

Quantitative Flow Visualization  

Microsoft Academic Search

Modern developments in laser and computer technology, electronic cameras, and digital image processing techniques allow to generate planar distributions of quantitative data in turbulent flows. Large amounts of data can be processed easily and analyzed statistically. With these tools, it is possible to quantitatively visualize turbulent coherent structures, even in flows of high Reynolds number, and measure characteristic spatial quantities

W. Merzkirch; D. Vitkin; W. Xiong

1998-01-01

188

Modeling Quantitative Literacy  

ERIC Educational Resources Information Center

Quantitative literacy is a habit of mind that is characterized by the interrelationship among a person's everyday understanding of mathematics, his or her beliefs about mathematics, and his or her disposition toward mathematics. To assess quantitative literacy, it is important to devise measurement tools that provide valid and reliable information…

Wilkins, Jesse L. M.

2010-01-01

189

Statistically Quantitative Volume Visualization  

Microsoft Academic Search

Visualization users are increasingly in need of techniques for assessing quantitative uncertainty and error in the im- ages produced. Statistical segmentation algorithms compute these quantitative results, yet volume rendering tools typi- cally produce only qualitative imagery via transfer function- based classification. This paper presents a visualization technique that allows users to interactively explore the un- certainty, risk, and probabilistic decision

Joe Michael Kniss; Robert L. Van Uitert Jr.; Abraham Stephens; Guo-shi Li; Tolga Tasdizen; Charles D. Hansen

2005-01-01

190

Johann von Lamont: A Pioneer in Geomagnetism  

NASA Astrophysics Data System (ADS)

The 200th birthday of John Lamont (1805-1879, Figure 1), a pioneer in the study of geomagnetism, was marked on 13 December 2005. Lamont founded the Munich Geomagnetic Observatory in 1840 and was a member of the group of scientists including Carl Friedrich Gauss, Alexander von Humboldt, Eduard Sabine, Jonas Angstrøm, Humphret Lloyd, Adolf Kupffer, Karl Kreil, and Adolphe Quetelet who composed the Göttingen Magnetic Union. They organized an international network of geomagnetic observatories [Barraclough et al., 1992]. The present knowledge of the geomagnetic field and its secular variation is largely based on the data collected by the global network of geomagnetic observatories during the last 170 years. Lamont's talents and his dedication and enthusiasm for discovery are reflected in the depth and scope of his contributions to a broad variety of natural sciences such as astronomy, meteorology, geomagnetism, and geodesy. However, this article just touches on his merits in geomagnetism.

Soffel, Heinrich

2006-06-01

191

Acoustic neuroma in von Recklinghausen's disease.  

PubMed

Bilateral acoustic neuromas are common in von Recklinghausen's disease. Their surgical removal likely will produce total hearing loss unless the lesions are small and intracanalicular. Therefore, a posterior fossa myelogram is indicated in all patients when a diagnosis of neurofibromatosis is made. To preserve hearing in resection of small tumors, a middle fossa approach is appropriate. In lesions slightly larger than intracanalicular size, hearing may be preserved with a two-stage middle fossa and transsigmoid approach. The prospect of total hearing loss and even facial diplegia predisposes to surgical procrastination. However, the morbidity and mortality associated with removal of medium and large tumors may be greater for neurofibromatosis than for patients with singular acoustic neuromas. Therefore, we believe it is not advisable to postpone operation when tumors extend into the cerebral pontine angle, even though it means loss of hearing. PMID:821153

Per-Lee, J H; Clairmont, A A

1976-07-01

192

Hermann von Helmholtz and his students  

NASA Astrophysics Data System (ADS)

During the years 1871-1888, when Hermann von Helmholtz was professor of physics at the University of Berlin, physicists from all over the world flocked to Berlin to study and do research with him. Among these were the German physicists Max Planck, Heinrich Kayser, Eugen Goldstein, Wilhelm Wien, and Heinrich Hertz, and Americans Henry Rowland, A. A. Michelson, and Michael Pupin. Examples of Helmholtz's scientific and personal interactions with these students and research associates show why he is justly considered the outstanding physics mentor of the 19th century. Both his ideas and his students played a major role in the development of physics in the late 19th and early 20th centuries.

Mulligan, Joseph F.

1989-01-01

193

Von Economo neurons in the elephant brain.  

PubMed

Von Economo neurons (VENs), previously found in humans, all of the great ape species, and four cetacean species, are also present in African and Indian elephants. The VENs in the elephant are primarily found in similar locations to those in the other species. They are most abundant in the frontoinsular cortex (area FI) and are also present at lower density in the anterior cingulate cortex. Additionally, they are found in a dorsolateral prefrontal area and less abundantly in the region of the frontal pole. The VEN morphology appears to have arisen independently in hominids, cetaceans, and elephants, and may reflect a specialization for the rapid transmission of crucial social information in very large brains. PMID:19089889

Hakeem, Atiya Y; Sherwood, Chet C; Bonar, Christopher J; Butti, Camilla; Hof, Patrick R; Allman, John M

2009-02-01

194

The von Hippel-Lindau Gene  

PubMed Central

Mutations or aberrations of the von Hippel-Lindau gene are responsible for the hereditary neoplastic syndrome that bears the same name, as well as for the majority of sporadic clear cell renal cell carcinomas. The discovery of this gene and subsequent clarification of its mechanism of action have led to a series of targeted treatments for advanced kidney cancer and have dramatically changed how we manage this disease. The discovery of the VHL gene is a prime example of how discoveries at the bench can inform and revolutionize therapeutics at the bedside. In this review, the authors trace this illuminating tale, from the cloning of the VHL gene, to elucidating its biologic function, to the development of novel therapeutics that have dramatically changed the paradigm of managing advanced renal cell carcinoma.

Clark, Peter E.; Cookson, Michael S.

2010-01-01

195

A generalized von Karman interpolation formula  

NASA Astrophysics Data System (ADS)

A parametrized family of three-dimensional angle-averaged spectral functions is proposed that well approximates existing formulas for the energy-containing portion of the spectrum (low-k) in free shear turbulence. The family includes the von Karman interpolation formula as a special case, and is based on it. Varying the parameter allows the height and width of the spectral peak to be varied smoothly, while maintaining the smooth interpolation between origin and inertial subrange behavior. The properties of this family of spectra are presented in a convenient non-dimensionalized form. As an example of the usefulness of the family of spectra, it is applied to the centerline turbulent energy of an axisymmetric jet in the far field to illustrate the effect of low-k spectral shape on the shift of the peak with Reynolds number (Re) when the energy is constant with Re.

Carhart, R. A.; Kostinski, A. B.

1988-11-01

196

Evidence-based recommendations on the treatment of von Willebrand disease in Italy  

PubMed Central

Background von Willebrand disease (VWD) is the most common hereditary bleeding disorder affecting both males and females. It arises from quantitative or qualitative defects of von Willebrand factor (VWF) and causes bleeding of mucous membranes and soft tissues. The aim of treatment is to correct the dual defect of haemostasis caused by the abnormal/reduced VWF and the concomitant deficiency of factor VIII (FVIII). Material and methods This document contains evidence-based recommendations for the management of VWD compiled by AICE (the Italian Association of Haemophilia Centres). All the evidence supporting these recommendations are based on non-randomised comparative studies or case series, because randomised controlled clinical trials or meta-analyses are not available for this disease. Results and conclusions Desmopressin (DDAVP) is the treatment of choice for patients with type 1 VWD with FVIII and VWF levels of 10 U/dL or more, while VWF/FVIII concentrates are indicated for those who are unresponsive or insufficiently responsive to DDAVP (severe type 1, type 2 and 3 VWD). VWF concentrates devoid of FVIII, not yet licensed in Italy, may be considered for short-term prophylaxis in elective surgery or for long-term secondary prophylaxis.

Mannucci, Pier Mannuccio; Franchini, Massimo; Castaman, Giancarlo; Federici, Augusto B.

2009-01-01

197

Neurofibromatosis of von Recklinghausen: A Quantitative Study of the Epidermal Keratinocyte and Melanocyte Populations  

Microsoft Academic Search

The numerical keratinocyte to melanocyte relation was studied in café au lait spots and adjacent normally pigmented skin of 9 patients with classical neurofibromatosis. Compared to normal skin of healthy individuals, the keratinocyte:melanocyte ratio distributions obtained in neurofibromatosis indicated a shift to lower values in the biopsies of café au lait spots and normally pigmented skin. These results are evidence

Edgar Frenk; Alfio Marazzi

1984-01-01

198

Histochemische, elektronenmikroskopische und quantitative Studien über den Glykogenvorrat der Plexus chorioidei von Rana temporaria L  

Microsoft Academic Search

The epithelial cells of the choroid plexuses (third and fourth ventricle) inRana temporaria L. are rich in glycogen. This material seems to represent a storage depot of carbohydrate within the brain. The glycogen particles (about 300 Å in diameter) of the plexus epithelium form rosettes or aggregates that are more irregular than the alpha particles described in the liver cell.

Eberhard Paul

1968-01-01

199

Neuer Ansatz zur Prüfung von Spanplatten auf silikatische Verunreinigungen  

Microsoft Academic Search

Zusammenfassung  Im Rahmen eines am Institut für Werkzeugmaschinen der Universität Stuttgart bearbeiteten\\u000a und von der AiF geförderten Forschungsvorhabens wird ein neuartiger, auf Funkenbildung basierender\\u000a Spanplattenschnelltest untersucht.

U. Heisel; J. Tröger; M. Schneider; S. Ivanova

2008-01-01

200

33. HISTORIC VIEW OF WERNHER VON BRAUN LOOKS THROUGH THE ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

33. HISTORIC VIEW OF WERNHER VON BRAUN LOOKS THROUGH THE PERISCOPE FROM THE CONTROL ROOM AT TEST STAND NO. 1, PEENEMUENDE. - Marshall Space Flight Center, Redstone Rocket (Missile) Test Stand, Dodd Road, Huntsville, Madison County, AL

201

Zur Lebensqualität nach chirurgischer Therapie von Mundhöhlenkarzinomen – eine retrospektive Multicenterstudie  

Microsoft Academic Search

Zusammenfassung\\u000a Fragestellung  Die operative Therapie von Mundhöhlenkarzinomen führt häufig zu funktionellen und ästhetischen Beeinträchtigungen. Sowohl\\u000a durch die notwendige Resektion des Tumors, als auch durch die adjuvante Radiochemotherapie kommt es häufig zur erheblichen\\u000a Destruktion physiologisch und anatomisch wichtiger Strukturen. Gegenstand der Untersuchung war zum einen die Auswirkung der\\u000a speziellen Rehabilitation des Zahnverlustes durch Anfertigung von funktionstüchtigem Zahnersatz auf die Lebensqualität. Zum\\u000a anderen

T. R. Hahn; G. Krüskemper; N. Enkling; N. R. Kübler

2007-01-01

202

Enossale Implantatversorgung von Tumorpatienten mit dem Bone-Lock-System  

Microsoft Academic Search

Zusammenfassung Die implantologische Versorgung von Patienten nach ablativer Tumorchirurgie und Defektrekonstruktion erfolgt meist abseits strenger Maßstäbe der Erfolgsbeurteilung. Deshalb untersuchten wir die von Juni 1990 bis Juni 1996 bei 58 Tumorpatienten enoral gesetzten 210 Implantate regelmäßig nach. Verwendung fand ausschließlich das enossale Bone-Lock-Implantatsystem (Howmedica Leibinger GmbH, Freiburg). Untersucht wurden der Plaqueindex (Silness und Löe), der Sulkusblutungsindex (Löe), die Sondierungstiefe, die

A. Kovács; Johann Wolfgang

1998-01-01

203

Autosomal Dominant von Willebrand Disease Type 2M  

Microsoft Academic Search

von Willebrand disease (VWD) type 2M is a distinct entity and clearly differs from type 1. The genotype-phenotype correlation for cases with ristocetin cofactor activity (RCo)\\/antigen (Ag) ratios <0.60 is clear, whereas the von Willebrand factor (VWF):collagen binding (CB)\\/VWF:Ag ratio is normal in VWD 2M. Typical laboratory features of VWD type 2 M are decreased ristocetin-induced platelet aggregation in the

Cedric Hermans; Javier Batlle

2009-01-01

204

Design und Evaluierung von Steganographie für Voice-over-IP  

Microsoft Academic Search

Aufbauend auf den Ergebnissen vorangegangener Arbeiten wird in die- sem Beitrag die Erweiterung eines Voice-over-IP-Frameworks um die Möglich- keit, geheime Kommunikation auf Basis von Steganographie durchzuführen, fort- gesetzt. Kommunikationspartner einer VoIP-Verbindung sind durch Nutzung des erweiterten Frameworks in der Lage, während einer VoIP-Sitzung geheime Nach- richten auszutauschen. Diese Arbeit greift auf bekannte Verfahren zum Verschlüs- seln und Einbringen von steganographischen

Thomas Vogel; Jana Dittmann; Reyk Hillert; Christian Krätzer

2006-01-01

205

Substance P immunoreactivity in rat von Ebner's gland  

Microsoft Academic Search

Summary  The present immunohistochemical study revealed substance P-immunoreactive neuronal elements in the von Ebner's gland of rats.\\u000a Immunoreactive ganglion cells were observed as single cells or groups of several immunoreactive ganglion cells among intra-lingual\\u000a muscles, at the base of the vallate papillae and near the von Ebner's gland. Very numerous substance P-immunoreactive varicose\\u000a nerve fibres ran closely associated with the serous

Yukio Oomori; Yohichi Satoh; Katsushi Ishikawa; Kazuyuki Ono

1995-01-01

206

Substance P immunoreactivity in rat von Ebner's gland  

Microsoft Academic Search

Summary  The present immunohistochemical study revealed substance P-immunoreactive neuronal elements in the von Ebner's gland of rats. Immunoreactive ganglion cells were observed as single cells or groups of several immunoreactive ganglion cells among intra-lingual muscles, at the base of the vallate papillae and near the von Ebner's gland. Very numerous substance P-immunoreactive varicose nerve fibres ran closely associated with the serous

Yukio Oomori; Yohichi Satoh; Katsushi Ishikawa; Kazuyuki Ono

1995-01-01

207

Einige weitere, von Luftverunreinigungen lebende Actinomyceten und ihre Klassifizierung  

Microsoft Academic Search

1.Die Fähigkeit zum Wachstum auf mineralischen Nährlösungen unter Ausnutzung von Luftverunreinigungen ist bei den Actinomyceten weit verbreitet.2.Von 39 benannten oder neu isolierten Teststämmen verschiedenster Herkunft vermochten 26 “oligocarbophil” zu wachsen; 5 Stämme stellten nach wenigen Tagen ihr Wachstum ein, und 8 Stämme vermehrten sich auf Mineralnährlösung nicht.3.In einigen Fällen wurde der Zuwachs durch Titration der gesamten Kultur auf Mineralnährlösung mit

Peter Hirsch

1960-01-01

208

Bedeutung von Rumination und Ablenkung für den Therapieerfolg depressiver Patienten  

Microsoft Academic Search

ZusammenfassungHintergrund: Nach der Response Styles Theorie von Nolen-Hoeksema [1991] trägt Grübeln in Reaktion auf depressive Stimmung zur Aufrechterhaltung und Intensivierung von Depressionen bei, während Ablenkung diese abschwächt. Studien zur Bedeutung der Reaktionsstile für den Therapieerfolg wurden bislang nur selten durchgeführt und die Befundlage ist uneinheitlich. Untersuchungen zur prädiktiven Bedeutung unterschiedlicher Arten depressiven Grübelns, z.B. symptomfokussiertes und selbstfokussiertes Grübeln, fehlen. Ziel

Tobias Teismann; Ulrike Willutzki; Johannes Michalak; Dietmar Schulte

2008-01-01

209

Zerebrale Hämodynamik während der Implantation von Kardioverter-Defibrillator-Systemen  

Microsoft Academic Search

Zusammenfassung\\u000a ? Grundproblematik  Bei der Implantation von automatischen implantierbaren Kardioverter-Defibrillatoren (ICD) muß zur Ermittlung der Funktion\\u000a und der optimalen Reizschwelle Kammerflimmern induziert werden, das einen Kreislaufstillstand und somit auch ein Sistieren\\u000a der Hirndurchblutung verursacht. Ziel der vorliegenden Studie war es, bei induziertem Kammerflimmern die Veränderungen der\\u000a zerebralen Blutflußgeschwindigkeit (CBFV(MCA)) in Abhängigkeit von der Länge der Fibrillationszeit und der Ausgangshöhe der CBFV(MCA)

Thorsten Jürgen Doering; Hans-Joachim Trappe; Bernhard Panning; Hans Gerd Fieguth; Birgit Steuernagel; Berthold Schneider; Siegfried Piepenbrock; Gisela Charlotte Fischer

1998-01-01

210

Mikrobiologische Überlegungen beim Einsatz von Antibiotika auf Intensivabteilungen  

Microsoft Academic Search

Zusammenfassung Da in vielen Fällen eine Initialtherapie ohne Erregernachweis durchzuführen ist, ist es für den Arzt von entscheidender Bedeutung zu wissen, welche Mikroorganismen auf Intensivstationen gehäuft auftreten. Es sind dieses heute in erster Linie gramnegative Erreger wieEnterobacteriaceae undPseudomonas-Spezies, wobei von Bedeutung ist, daß diese Keime häufig multiresistent sind. Nach wie vor spielen dagegen aber auch noch Staphylokokken und andere grampositive

H. Knothe; W. Sietzen

1978-01-01

211

[Prevalence, pathophysiology, diagnosis and treatment of von Willebrand syndrome in orthopedic trauma patients].  

PubMed

The von Willebrand's Disease affects about 1-3% of the population and it is undiagnosed in most people. Originally described by the Finish physician Erik von Willebrand in 1926 this disorder is associated with mucous membrane bleeding including epistaxis, hypermenorhoea and excessive bleeding from surgery and dental procedures. In von Willebrands disease the patients have a quantitative or qualitative abnormality in the von Willebrand Factor (vWF) which has two major functions: it serves by bridging between platelets and injury site in the blood vessel wall, and it circulates as a complex with factor VIII, protecting it from rapid degradation. More than 20 different types and subtypes of vWD have been described but almost all patients can be classified as having 1 of the 2 most common types of vWD. About 70% of patients have type 1 and about 10-20% present themself with type 2A and 2B vWD type 3 in about 10%. By taking a clinical history of bleeding it is important to think about vWD and to make the appropriate diagnosis. If the vWD is suspected diagnostic tests should include an activated partial thromboplastin time, bleeding time, factor VIII:C, Ristocetin cofactor, and vWF antigen. Additional testing of ristocetin induced plattlet adhesion (RIPA), the multimeric structure and collagen binding test and genanalysis allow diagnosing the different types of v. Willebrand Disease. The treatment of choice in mild forms is the synthetic agent desmopressin. In patients with severe type 1, type 2B, 2N and type 3 or in people who do not response to desmopressin, the appropriate treatment is a factor VIII concentrate that is rich of vWF. Until now no recommendations in the orthopaedic literature have been found regarding diagnosis and treatment of vWS patients. Based on the experience with 43 orthopaedic patients presenting vWD over the last 15 years a contemporary guideline for the successful perioperative management of vWD in orthopaedic surgery is presented. In a close collaboration between the orthopaedic surgeon and the specialized haemostaseologist every invasive procedure in patients with vWD can be undertaken without the risk of excessive bleeding. PMID:10335531

Kurth, A A; Ludwig, G; Scharrer, I

1999-04-01

212

Changes in Thermodynamic Stability of von Willebrand Factor Differentially Affect the Force-Dependent Binding to Platelet GPIb?  

PubMed Central

Abstract In circulation, plasma glycoprotein von Willebrand Factor plays an important role in hemostasis and in pathological thrombosis under hydrodynamic forces. Mutations in the A1 domain of von Willebrand factor cause the hereditary types 2B and 2M von Willebrand disease that either enhance (2B) or inhibit (2M) the interaction of von Willebrand factor with the platelet receptor glycoprotein Ib?. To understand how type 2B and 2M mutations cause clinically opposite phenotypes, we use a combination of protein unfolding thermodynamics and atomic force microscopy to assess the effects of two type 2B mutations (R1306Q and I1309V) and a type 2M mutation (G1324S) on the conformational stability of the A1 domain and the single bond dissociation kinetics of the A1-GPIb? interaction. At physiological temperature, the type 2B mutations destabilize the structure of the A1 domain and shift the A1-GPIb? catch to slip bonding to lower forces. Conversely, the type 2M mutation stabilizes the structure of the A1 domain and shifts the A1-GPIb? catch to slip bonding to higher forces. As a function of increasing A1 domain stability, the bond lifetime at low force decreases and the critical force required for maximal bond lifetime increases. Our results are able to distinguish the clinical phenotypes of these naturally occurring mutations from a thermodynamic and biophysical perspective that provides a quantitative description of the allosteric coupling of A1 conformational stability with the force dependent catch to slip bonding between A1 and GPIb?.

Auton, Matthew; Sedlak, Erik; Marek, Jozef; Wu, Tao; Zhu, Cheng; Cruz, Miguel A.

2009-01-01

213

Ocular Von Hippel-Lindau Disease: Clinical Update and Emerging Treatments  

PubMed Central

Purpose of review von Hippel-Lindau (VHL) disease is an inherited, multi-systemic cancer syndrome often involving the retina. This review will provide an update for the clinical characterization and treatment of ocular VHL disease. Recent findings A comprehensive and quantitative clinical characterization of ocular VHL disease has been limited by small patient numbers and non-representative sampling. Recently, a large population of patients with clinically and genetically defined VHL disease has systemically characterized in a single center, enabling a quantitative evaluation of the ocular involvement of this syndrome. Correlations between the nature of VHL gene mutations and the ocular phenotype were also examined, providing clues as to how disruptions in VHL protein function may result in eye disease. This understanding may be relevant to the development of new therapies targeting the molecular biology of VHL disease, some of which are presently being investigated. Summary Quantitative studies enable a full characterization of the impact of VHL disease on eye health and visual function. Establishing correlations between the genotype of the VHL mutation and the phenotype of eye disease may inform us as to how ocular VHL disease arises, and help guide molecular interventions in ocular VHL disease.

Wong, Wai T.; Chew, Emily Y.

2010-01-01

214

Quantitative film radiography  

SciTech Connect

We have developed a system of quantitative radiography in order to produce quantitative images displaying homogeneity of parts. The materials that we characterize are synthetic composites and may contain important subtle density variations not discernible by examining a raw film x-radiograph. In order to quantitatively interpret film radiographs, it is necessary to digitize, interpret, and display the images. Our integrated system of quantitative radiography displays accurate, high-resolution pseudo-color images in units of density. We characterize approximately 10,000 parts per year in hundreds of different configurations and compositions with this system. This report discusses: the method; film processor monitoring and control; verifying film and processor performance; and correction of scatter effects.

Devine, G.; Dobie, D.; Fugina, J.; Hernandez, J.; Logan, C.; Mohr, P.; Moss, R.; Schumacher, B.; Updike, E.; Weirup, D.

1991-02-26

215

Variabilität des Reviergesangs des Buchfinken (Fringilla coelebs) zur Raum-Zeit-Beschreibung von Metapopulationen  

NASA Astrophysics Data System (ADS)

Der Buchfinkengesang wurde in Potsdam in zwei Hauptpopulationen über drei Jahre aufgenommen. Jedes Individuum wurde eindeutig am individuellen Strophentypenrepertoire identifiziert. Ein weiterer Punkt der die individuelle Wiedererkennung bestätigt ist die hohe Standorttreue der adulten Männchen. Die beschriebene Methode eignet sich für die Untersuchung von gesamten Populationen, um den Wandel des Gesangs von Populationen in Raum und Zeit zu beschreiben. Die Haupterkenntnisse der Arbeit sind: - Die Gesamtanzahl der Grundstrophentypen innerhalb einer Population bleibt über Jahre konstant. - Die relative Häufigkeit jedes einzelnen Strophentyps variiert von Jahr zu Jahr und von Population zu Population. - Gesangslernen erfolgt exakt mit einem Korrektheitsgrad von mindestens 96%. - Das Song-Sharing ist innerhalb der Population hoch. Die diskutierten Mechanismen für das Song-Sharing sind: Die Lebenserwartung, das Zugverhalten, das Lernverhalten, die Etabliertheit von Strophentypen, Weibchenpräferenzen und die Reaktionen der territorialen Männchen. - Weiterhin wurde ein Modell zur kulturellen Evolution des Buchfinkengesangs programmiert, um die Rolle der Einflussfaktoren, wie Fehlerquote, Abwanderungsrate und Laufzeit zu ermitteln. Der Wandel des Dialektes erfolgt graduell in Raum und Zeit. Daher sind keine scharfen Dialektgrenzen anzutreffen. Trotz dieser Tatsache markieren die etablierten Strophentypen die Population. 50 % der Juvenilen siedeln am Geburtsort, auf diese Weise bleibt der Dialekt erhalten und Inzest wird vermieden. -Analysiert man das Repertoire benachbarten Männchen bei isolierten Alleen, so entspricht die Gesangsangleichung in etwa dem Zufall. -Intraindividuelle Vergleiche der quantitativen Parameter des jeweiligen Strophentyps wurden saisonal und annuell durchgeführt. Saisonal konnten für einen Strophentyp ein Trend ermittelt werden. Bei jährlichen Vergleichen konnten intraindividuell ausschließlich nicht signifikante Ergebnisse ermittelt werden, wohingegen die interindividuelle Variation in zwei Fällen signifikant war. In einem Fall bestand ein Trend und in einem weiteren Fall war die Variationsunterschiede nicht signifikant. - Der Verlauf der Brutsaison lässt sich an der jährlichen Gesangsaktivität nachvollziehen. Chaffinch song was recorded in Potsdam in two major populations of chaffinches over a period of three years. Each male was identified unambiguously because of their individual song type repertoires. These are usually easy to distinguish from sonagrams as the variation is discontinuous. A further point for individual recognition is the fixed territorial behaviour of adult males. The described method is employed to examine whole populations and to observe changes with space and time in the song of a population. The major findings of the study are: - The total amount of basic song types in each population is constant over years. - The quantity of each basic song type is different and varies from year to year and from population to population. - Song copying is extremely accurate on at least 96% of occasions. - Song-type sharing is high within populations. Discussed mechanisms for song neighbourhoods are: expectation of life, semi-migratory behaviour, learning skills, establishment of song types, female choice and male vs male interaction. Furthermore a model of cultural evolution of chaffinch song was programmed to determine the role of factors like error rate, rate of emigration and running time. The changes are gradual in space and time. Hence the dialect borders are smooth. Despite this fact established song types mark the population. As every second juvenile bird settles in the population of his birth inbreeding is avoided and the dialect structure is retained. - Analysing the repertoires of neighbouring males (“next door neighbours”) in isolated avenues to examine mutual influences suggests that these have the same amount of song types in common than would be expected by chance. - Within intraindividual comparisons the quantitative parameters of the same son

Nolte, Björn

2003-10-01

216

Quantitative receptor autoradiography  

SciTech Connect

Quantitative receptor autoradiography addresses the topic of technical and scientific advances in the sphere of quantitative autoradiography. The volume opens with a overview of the field from a historical and critical perspective. Following is a detailed discussion of in vitro data obtained from a variety of neurotransmitter systems. The next section explores applications of autoradiography, and the final two chapters consider experimental models. Methodological considerations are emphasized, including the use of computers for image analysis.

Boast, C.A.; Snowhill, E.W.; Altar, C.A.

1986-01-01

217

The molecular analysis of von Willebrand disease: a guideline from the UK Haemophilia Centre Doctors' Organisation Haemophilia Genetics Laboratory Network.  

PubMed

von Willebrand disease (VWD) is a common autosomally inherited bleeding disorder associated with mucosal or trauma-related bleeding in affected individuals. VWD results from a quantitative or qualitative deficiency of von Willebrand factor (VWF), a glycoprotein that is essential for primary haemostasis and that carries and protects coagulation factor VIII (FVIII) in the circulation. Through characterization of the phenotype and identification of mutations in the VWF gene in patients with VWD, understanding of the genetics and biochemistry of VWF and VWD has advanced considerably. The importance of specific regions of VWF for its interaction with other components of the vasculature has been revealed, and this has facilitated the formal classification of VWD into three subtypes based upon quantitative (types 1 and 3) and qualitative (type 2) deficiency of VWF. The underlying genetic lesions and associated molecular pathology have been identified in many cases of the qualitative type 2 VWD variants (2A, 2B, 2M, 2N) and in the severe quantitative deficiency, type 3 VWD. However in the partial quantitative deficiency, type 1 VWD, the picture is less clear: there is a variable relationship between plasma levels of VWF and bleeding, there is incomplete penetrance and variable expressivity within affected families, the causative molecular defect is unknown in a substantial number of cases, and even in those cases where the causative mutation is known, the associated molecular pathology is not necessarily understood. This guideline aims to provide a framework for best laboratory practice for the genetic diagnosis of VWD, based upon current knowledge and understanding. PMID:18637846

Keeney, S; Bowen, D; Cumming, A; Enayat, S; Goodeve, A; Hill, M

2008-07-14

218

Quantitative Decision Support Requires Quantitative User Guidance  

NASA Astrophysics Data System (ADS)

Is it conceivable that models run on 2007 computer hardware could provide robust and credible probabilistic information for decision support and user guidance at the ZIP code level for sub-daily meteorological events in 2060? In 2090? Retrospectively, how informative would output from today’s models have proven in 2003? or the 1930’s? Consultancies in the United Kingdom, including the Met Office, are offering services to “future-proof” their customers from climate change. How is a US or European based user or policy maker to determine the extent to which exciting new Bayesian methods are relevant here? or when a commercial supplier is vastly overselling the insights of today’s climate science? How are policy makers and academic economists to make the closely related decisions facing them? How can we communicate deep uncertainty in the future at small length-scales without undermining the firm foundation established by climate science regarding global trends? Three distinct aspects of the communication of the uses of climate model output targeting users and policy makers, as well as other specialist adaptation scientists, are discussed. First, a brief scientific evaluation of the length and time scales at which climate model output is likely to become uninformative is provided, including a note on the applicability the latest Bayesian methodology to current state-of-the-art general circulation models output. Second, a critical evaluation of the language often employed in communication of climate model output, a language which accurately states that models are “better”, have “improved” and now “include” and “simulate” relevant meteorological processed, without clearly identifying where the current information is thought to be uninformative and misleads, both for the current climate and as a function of the state of the (each) climate simulation. And thirdly, a general approach for evaluating the relevance of quantitative climate model output for a given problem is presented. Based on climate science, meteorology, and the details of the question in hand, this approach identifies necessary (never sufficient) conditions required for the rational use of climate model output in quantitative decision support tools. Inasmuch as climate forecasting is a problem of extrapolation, there will always be harsh limits on our ability to establish where a model is fit for purpose, this does not, however, limit us from identifying model noise as such, and thereby avoiding some cases of the misapplication and over interpretation of model output. It is suggested that failure to clearly communicate the limits of today’s climate model in providing quantitative decision relevant climate information to today’s users of climate information, would risk the credibility of tomorrow’s climate science and science based policy more generally.

Smith, L. A.

2009-12-01

219

Von Willebrand factor/factor VIII concentrates in the treatment of von Willebrand disease.  

PubMed

Therapy for von Willebrand disease (VWD) aims to restore the hemostatic function conferred by von Willebrand factor (VWF), which facilitates platelet adhesion and aggregation, and serves to increase potentially low coagulation factor VIII (FVIII) in plasma. In patients unresponsive to desmopressin (DDAVP), the preferred treatment is with plasma-derived VWF-containing FVIII concentrates. Only a few of the available VWF/FVIII concentrates have been licensed for use in VWD based on prospective studies. The efficacy of VWF/FVIII concentrates depends on the content and quality of VWF and FVIII. Several studies have demonstrated the variability of the VWF contents, as well as the differences in the VWF multimer patterns (including the high molecular weight VWF multimers that are most effective in restoring hemostasis), among these concentrates. Treating physicians should be aware of these disparities and the potential clinical implications for patients with different VWD subtypes. Dosing has traditionally been calculated based on the FVIII content of the products, although dosing based on VWF functional activity [e.g., VWF ristocetin cofactor activity (VWF:RCo)] addresses the primary protein deficiency in VWD patients. Several clinical studies have demonstrated the efficacy of concentrates dosed according to VWF:RCo. Dosing is generally consistent across VWD subtypes, although patients with severe phenotypes or undergoing major procedures may require more infusions or longer treatment duration. Other considerations for the use of VWF-containing concentrates include laboratory monitoring of efficacy and safety issues such as thrombosis risk and thromboprophylaxis. PMID:19786936

Batlle, Javier; López-Fernández, María Fernanda; Fraga, Esther Lourés; Trillo, Angela Rodríguez; Pérez-Rodríguez, María Almudena

2009-03-01

220

An Alternative to Von Glasersfeld's Subjectivism in Science Education: Deweyan Social Constructivism.  

ERIC Educational Resources Information Center

Discusses von Glasersfeld's view of constructivism in science and mathematics educational research and practice. Provides a social constructivist alternative to von Glaserfeld's subjectivist constructivism. Discusses the practical art of experimental construction and objectivity in science education. (Author/JRH)

Garrison, Jim

1997-01-01

221

Neuraxial anesthesia for cesarean delivery in a parturient with type 1 von Willebrand disease and scoliosis  

Microsoft Academic Search

We present the case of a parturient with von Willebrand disease and scoliosis who required cesarean delivery. Neuraxial anesthesia was used for the patient. The indications for neuraxial anesthesia with regard to type 1 von Willebrand disease are reviewed.

Alexander J. Butwick; Brendan Carvalho

2007-01-01

222

Quantitative phase spectroscopy  

PubMed Central

Quantitative phase spectroscopy is presented as a novel method of measuring the wavelength-dependent refractive index of microscopic volumes. Light from a broadband source is filtered to an ~5 nm bandwidth and rapidly tuned across the visible spectrum in 1 nm increments by an acousto-optic tunable filter (AOTF). Quantitative phase images of semitransparent samples are recovered at each wavelength using off-axis interferometry and are processed to recover relative and absolute dispersion measurements. We demonstrate the utility of this approach by (i) spectrally averaging phase images to reduce coherent noise, (ii) measuring absorptive and dispersive features in microspheres, and (iii) quantifying bulk hemoglobin concentrations by absolute refractive index measurements. Considerations of using low coherence illumination and the extension of spectral techniques in quantitative phase measurements are discussed.

Rinehart, Matthew; Zhu, Yizheng; Wax, Adam

2012-01-01

223

Mikrobiologische Aktivität von Cefoxitin im Vergleich zu anderen Beta-Laktam-Antibiotika  

Microsoft Academic Search

Zusammenfassung Bei einem Vergleich der antibakteriellen Aktivität von Chemotherapeutika ergeben sich bekanntlich eine Reihe von Schwierigkeiten, die ursächlich durch unterschiedliche Stammkollektive, darüber hinaus aber auch durch Nährmedien und andere Faktoren bedingt sind. Bei einem Vergleich der antibakteriellen Aktivität von Cefoxitin im Vergleich zu anderen Beta-Laktam-Antibiotika zeigt sich, daß Cefoxitin eine gute Aktivität gegenüber grampositiven Erregern sowie Stämmen vonHaemophilus influenzae besitzt.

H. Knothe

1979-01-01

224

Quantitative Population Ecology  

NSDL National Science Digital Library

Dr. Alexei Sharov of the Department of Entomology at Virginia Tech has put together this excellent teaching resource on quantitative population ecology. The online resource contains thirteen lecture handouts and eight labs, targeting beginning graduate or advanced undergraduate students; the course requires a basic understanding of statistics and ecology. Each chapter contains a concise introduction to the topic plus several more detailed subsections. The chapters are well organized and easy to navigate, and include useful color illustrations and mathematical equations. For educators and students of quantitative population ecology alike, this exceptional resource is hard to beat.

225

Erklärungsansätze für vertragswidriges Verhalten von Versicherungsnehmern aus Sicht der ökonomischen Theorie  

Microsoft Academic Search

Ziel dieser Arbeit ist es, in die ökonomische Analyse des Versicherungsbetrugs einzuführen und einige grundlegende Determinanten für vertragswidriges Verhalten von Versicherungsnehmern aufzuzeigen. Dazu werden zunächst die strategischen Entscheidungsprobleme von Versicherungsnehmern und Versicherern eingehend analysiert und optimales Verhalten unter realitätsnahen Annahmen hergeleitet, sowie Ansatzpunkte für die Betrugsbekämpfung aufgezeigt. Beispielhaft werden dazu die Auswirkungen von Betrugserkennungssystemen oder die konsequente Anzeige entdeckter Betrüger

Martin Nell; Jörg Schiller

2002-01-01

226

Nachweis von Nerven in Rachen-und Gaumenmandeln – Ein morphologischer Beitrag zur Neuroimmunologie der Tonsillen  

Microsoft Academic Search

Zusammenfassung Mit der Silberimprägnationsmethode gelang uns der Nachweis von Nerven in menschlichem Tonsillengewebe und erstmals auch im Tonsillenparenchym. Grobe Nervenstränge ziehen, zum Teil unabhängig von den Gefássen, von der Kapsel in das Innere der Tonsillen, wo sie sich in feinere Nerven aufteilen. Sie finden sich überwiegend in den bindegewebigen Septen und nur vereinzelt im Parenchym. Charakteristisch für die Innervation der

Markus M. Hess; Jürgen Krüger; G. E. K. Novotny; Christiane Thomas; Jürgen Lamprecht

1991-01-01

227

Sequenzorientierte Policy-Analyse: Warum die Rentenreform von Walter Riester nicht an Reformblockaden scheiterte  

Microsoft Academic Search

Aufgrund der Eigentümlichkeiten des deutschen Regierungssystems gehen viele politikwissenschaftliche Studien von der Blockadethese aus. Die Blockadethese gründet in der Annahme gegebener Präferenzen und stabiler institutioneller Rahmenbedingungen und führt auf der analytischen Ebene zu am Rationalwahlansatz orientierten Interaktionsanalysen, die politische Entscheidungen von der Veränderung gesellschaftlicher Probleme, Präferenzen und institutioneller Rahmenbedingungen isoliert betrachten. Interaktionsorientierte Analysen fokussieren auf die Erklärung von inkrementellen Policy-Wandel.

Christine Trampusch

2005-01-01

228

Mechanisch induzierte Dissoziation von Kalzium vom kontraktilen Apparat elektrisch stimulierter, intakter, menschlicher, atrialer Trabekel  

Microsoft Academic Search

Zusammenfassung Die kurzzeitige Kalzium-Akkumulation im myokardialen Gewebe bei isotoner Kontraktion ist von klinischer Bedeutung, da die Kalziumüberladung des Zytosols ursächlich an der Entstehung von Rhythmusstörungen beteiligt ist. Unklar ist derzeit, woher das überschüssige Kalzium stammt, ob aus intrazellulären Speichern, modifizierten Membranströmen oder von Seiten des kontraktilen Apparates. Ziel dieser Arbeit ist es zu klären, 1) an welcher Stelle in der

N. Kayhan; G. Reinerth; O. Dössel; C.-F. Vahl

2004-01-01

229

Acute myocardial infarction in a patient with von Willebrand disease: pathogenetic dilemmas and therapeutic challenges.  

PubMed

Acute myocardial infarction occurs very rarely in patients with von Willebrand disease, a hereditary bleeding disorder characterized by deficiency of von Willebrand factor. We report a 45-year-old woman with von Willebrand disease who presented with acute anterior myocardial infarction. Percutaneous coronary intervention with adjuvant antiplatelet and antithrombotic therapy was performed without significant bleeding complications. PMID:12368516

Arjomand, Heidar; Aquilina, Patrick; McCormick, Daniel

2002-10-01

230

Optimiertes Aggregate Management - Das "Poolen`` von Aggregaten und das "Bündeln`` von Leistungen ist eine Chance zur Kostensenkung  

NASA Astrophysics Data System (ADS)

Das "Poolen“ von Aggregaten und das "Bündeln“ von Leistungen ist eine Chance zur Kostensenkung. In diesem Beitrag wird am Beispiel der InfraServ Knapsack gezeigt, wie durch sinnvolle Synergien erhebliche Kosten eingespart werden können. Zu einem modernen und flexiblen Full-Service-Anbieter im Aggregate Management gehören neben verfahrenstechnischem und werkstoffwissenschaftlichem Know-How vor allem auch der praktische Umgang mit Analysemethoden wie Life Cycle Costing (LCC) oder Root Cause Analysis (RCA). Auch eine optimale Aggregatauslegung ist im Hinblick auf stetig steigende Energiekosten für die Betreiber ein wichtiger Zusatznutzen. Im Folgenden werden neben den Methoden und den damit erzielten Kostenreduzierungen an aktuellen Beispielen aus dem Betriebsalltag von Chemie- und Infrastrukturanlagen auch die benötigten Services für ein effizientes "Poolen“ dargestellt. Bei Beteiligung an einem existenten Aggregatepool oder Gründung und Zusammenschluss zu einem neuen Pool kann man zudem von den Kenntnissen und Erfahrungen Anderer profitieren. Vorhaltekosten von Ersatzteilen und Ersatzaggregaten können durch einen Pool drastisch reduziert werden. Darüber hinaus kann der Full-Service-Anbieter auch die benötigten Investitionsmittel zu Anschaffung kompletter Aggregate zur Verfügung stellen. Die in Knapsack heute anzutreffende Lösung wurde über Jahre entwickelt und ist im Folgenden kurz zusammengefasst.

Zarbock, Dietmar; Bachem, Werner

231

Der Stoffwechsel von Xylit bei normalen und alloxandiabetischen Kaninchen  

Microsoft Academic Search

Zusammenfassung  \\u000a \\u000a \\u000a \\u000a 1. \\u000a \\u000a Die Umsatzkinetik von Xylit und der Einflu\\\\ auf den Glucose- und Fettsäurestoffwechsel normaler und alloxandiabetischer Kaninchen\\u000a wurde mittels kontinuierlicher intravenöser und intraduodenaler Infusion studiert.\\u000a \\u000a \\u000a \\u000a \\u000a 2. \\u000a \\u000a Xylit wird von normalen wie von alloxandiabetischen Tieren etwa ebensogut wie Fructose utilisiert. 70% der intravasal zugeführten\\u000a Menge werden in der Leber umgesetzt, etwa 15% in extrahepatischen Geweben.\\u000a \\u000a \\u000a \\u000a \\u000a 3. \\u000a \\u000a Xylit wird passiv resorbiert

F. Müller; E. Strack; E. Kuhfahl; D. Dettmer

1967-01-01

232

Gunther von Hagens' BODY WORLDS: selling beautiful education.  

PubMed

In the BODY WORLDS exhibitions currently touring the United States, Gunther von Hagens displays human cadavers preserved through plastination. Whole bodies are playfully posed and exposed to educate the public. However, the educational aims are ambiguous, and some aspects of the exhibit violate human dignity. In particular, the signature cards attached to the whole-body plastinates that bear the title, the signature of Gunther von Hagens, and the date of creation mark the plastinates as artwork and von Hagens as the artist in a gesture that strips the personal dignity from the donors. I conclude that the educational use of cadavers is compatible with respect for dignity if: 1) the utility of such use is great enough; 2) there are no other ways of achieving these ends; and 3) every effort is made to honor the dignity of the donors. PMID:17454986

Burns, Lawrence

2007-04-01

233

Quantitative Spectroscopy of Deneb  

Microsoft Academic Search

Context: Quantitative spectroscopy of luminous BA-type supergiants offers a high potential for modern astrophysics. Detailed studies allow the evolution of massive stars, galactochemical evolution, and the cosmic distance scale to be constrained observationally. Aims: A detailed and comprehensive understanding of the atmospheres of BA-type supergiants is required in order to use this potential properly. The degree to which we can

Florian Schiller; Norbert Przybilla

2007-01-01

234

Quantitative Compliant Control  

Microsoft Academic Search

An architecture-independent analysis approach is described for evaluation of control systems designed to provide compliant manipulator\\/task interaction. Two issues are highlighted: a safety bound that provides an explicit, quantitative design objective, and an examination of typical task dynamics and their impact on the difficulty (complexity) of control design. Two examples of control design within this framework are presented, demonstrating the

Dale A. Lawrence; Jim D. Chapel

1993-01-01

235

Multiframe quantitative coronary arteriography  

Microsoft Academic Search

Single-frame quantitative coronary angiography (QCA) requires a human operator to select one frame for analysis out of typically 90 or more acquired in each sequence. QCA measurements for the same arterial segment differ from frame to frame due to a variety of factors including: rapid coronary motion, overlapping arteries, patient scatter, and structure noise from imaging the ribs, spine and

Craig A. Morioka; James S. Whiting; Miguel P. Eckstein; Kokila Shah

1996-01-01

236

Quantitative Continuous Domains  

Microsoft Academic Search

We relate two approaches to Quantitative Domain Theory, the partial metrics of Steve Matthews and the measurements of Keye Martin, by showing that stable partial metrics are in one-to-one correspondence to weakly modular measurements. It is shown that every ?-algebraic domain admits a partial metric whose associated measurement assigns zero precisely to the set of maximal elements, a condition which

Pawel Waszkiewicz

2003-01-01

237

An Accurate von Neumann's Law for Three-Dimensional Foams  

SciTech Connect

The diffusive coarsening of 2D soap froths is governed by von Neumann's law. A statistical version of this law for dry 3D foams has long been conjectured. A new derivation, based on a theorem by Minkowski, yields an explicit analytical von Neumann's law in 3D which is in very good agreement with detailed simulations and experiments. The average growth rate of a bubble with F faces is shown to be proportional to F{sup 1/2} for large F , in contrast to the conjectured linear dependence. Accounting for foam disorder in the model further improves the agreement with data.

Hilgenfeldt, Sascha; Kraynik, Andrew M.; Koehler, Stephan A.; Stone, Howard A.

2001-03-19

238

Okuläres vernarbendes PemphigoidRetrospektive Analyse von Risikofaktoren und Komplikationen  

Microsoft Academic Search

Zusammenfassung  \\u000a Das vernarbende Pemphigoid (cicatricial pemphigoid, CP) ist eine seltene, mit subepidermaler Blasenbildung und Vernarbung\\u000a einhergehende Autoimmunerkrankung, die sich an Haut und Schleimhaut manifestiert. Eine Augenbeteiligung liegt bei etwa 70%\\u000a der Patienten vor.\\u000a \\u000a \\u000a Methode: Retrospektiv wurden Krankheitsverlauf, klinische Komplikationen und mögliche Risikofaktoren von Patienten der Augen- und\\u000a Hautklinik mit vernarbendem Pemphigoid von 1986–1998 untersucht.\\u000a \\u000a \\u000a \\u000a \\u000a Ergebnisse: 18\\/28 Patienten (64%) mit CP

E. M. Messmer; C. R. Hintschich; K. Partscht; G. Messer; A. Kampik

2000-01-01

239

Langzeitresultate mit der Implantation von Hydroxylapatit als Bulbusersatz  

Microsoft Academic Search

Zusammenfassung  \\u000a \\u000a Hintergrund: Seit der ersten Implantation von Hydroxylapatit als Bulbusersatz 1985 in den Vereinigten Staaten zählt es in Deutschland\\u000a zu einem selten verwendeten Orbitaimplantat. Ziel der Studie war es, Daten über die Langzeitverträglichkeit, postoperative\\u000a Komplikationen sowie über das funktionell-ästhetische Resultat zu erhalten.\\u000a \\u000a \\u000a \\u000a \\u000a Patienten und Methode: In einer im Frühjahr 1997 durchgeführten Studie konnten 52 Patienten, die im Zeitraum von Oktober

A. G. Norda; H.-W. Meyer-Rüsenberg

2000-01-01

240

Vergleichbare Antibiotikaresistenz von Pneumokokkenisolaten HIV-positiver und -negativer Patienten  

Microsoft Academic Search

Zusammenfassung\\u000a Hintergrund und Ziel:  HIV-Patienten sind häufiger der Hospitalisation, Immunsuppression und Antibiotikaprophylaxen ausgesetzt. Daher ist bei HIV-positiven\\u000a Patienten vermehrt mit resistenten Bakterienstämmen zu rechnen. Zweck dieser Fall-Kontroll-Studie war es, die Empfindlichkeit\\u000a von Pneumokokken erwachsener Patienten in Abhängigkeit von deren HIV-Status sowie die Patientenkollektive zu vergleichen.\\u000a \\u000a \\u000a \\u000a Patienten und Methodik:  Zwischen Januar 2001 und Dezember 2005 wurden Proben internistischer Patienten eines universitären Labors auf

Christoph Stephan; Gudrun Just-Nübling; Susanne Franck; Markus Bickel; Pramod M. Shah; Errol Babacan; Schlomo Staszewski

2008-01-01

241

Anwendung von Methoden der Logistik und Netzplantechnik zur präzedenz- und ressourcenbeschränkten Ablaufplanung von Echtzeitsystemen  

NASA Astrophysics Data System (ADS)

Grundlegende Zusammenhänge zwischen Logistik, Netzplantechnik und Echtzeit sowie den zugehörigen Arten der Ablaufplanung und ihrer Nutzung werden dargestellt. Das Echtzeitprinzip beinhaltet Rechtzeitigkeit von Abläufen, wobei es für eine frühzeitige Beendigung eines Ablaufs keinen Bonus gibt; im Gegensatz zum verspäteten Ablauf, dessen Konsequenzen in der Regel negativ und unabschätzbar sind. Das Just-in-Time-Prinzip gleicht dem der Echtzeit und wird vor allem in der Logistik zur Bezeichnung reibungsloser Abläufe in Beschaffungsketten verwendet. In der Netzplantechnik werden die kritischen Aktivitäten binnen eines Projektes bestimmt, die nicht verzögert werden dürfen, um das Projekt rechtzeitig zu beenden. Außerdem haben die drei Bereiche noch eine Gemeinsamkeit: um realistische Ablaufszenarien darzustellen, müssen in den Analysen auch begrenzte Ressourcen angemessen berücksichtigt werden.

Gumzej, Roman; Lipi?nik, Martin

242

Changes of von Willebrand Factor during Pregnancy in Women with and without von Willebrand Disease.  

PubMed

Delivery in von Willebrand disease (VWD) represents a significant hemostatic challenge because of the variable pattern of changes observed during pregnancy of von Willebrand factor (VWF) and factor VIII (FVIII), the protein carried by VWF. Since a wide heterogeneity of phenotypes and of the underlying pathophysiological mechanisms is associated with this disorder, a prompt and careful evaluation of pregnant women with VWD is requested in order to plan the most appropriate treatment at time of parturition. VWF and FVIII increase significantly during pregnancy in normal women, already within the first trimester, reaching levels by far >100 U/dL by the time of parturition. Women with VWD, levels at baseline of VWF and FVIII >30 U/dL have us a high likelihood to achieve normal levels at the end of pregnancy; thus specific anti-hemorrhagic prophylaxis is seldom required. Women with basal level <20 U/dL usually have a poor increase since most of these women carry mutations associated with increased VWF clearance or are compound heterozygous for different VWF mutations; that prevent the achievement of satisfactory hemostatic levels. While women with mutations associated with increased clearance show a full, albeit transitory correction of their hemostatic deficiency after desmopressin administration, compound heterozygous need replacement therapy because they do not respond well to this agent. Patients with abnormal VWF:RCo/VWF:Ag ratio at baseline (e.g. <0.6), typically associated with type 2 VWD, maintain the abnormality throughout pregnancy and VWF:RCo usually does not attain safe levels ?50 U/dL. These women require replacement therapy with VWF-FVIII concentrates. Delayed post-partum bleeding may occur when replacement therapy is not continued for some days. Tranexamic acid may be useful at discharge to avoid excessive lochia. PMID:23936623

Castaman, Giancarlo

2013-07-16

243

Changes of von Willebrand Factor during Pregnancy in Women with and without von Willebrand Disease  

PubMed Central

Delivery in von Willebrand disease (VWD) represents a significant hemostatic challenge because of the variable pattern of changes observed during pregnancy of von Willebrand factor (VWF) and factor VIII (FVIII), the protein carried by VWF. Since a wide heterogeneity of phenotypes and of the underlying pathophysiological mechanisms is associated with this disorder, a prompt and careful evaluation of pregnant women with VWD is requested in order to plan the most appropriate treatment at time of parturition. VWF and FVIII increase significantly during pregnancy in normal women, already within the first trimester, reaching levels by far >100 U/dL by the time of parturition. Women with VWD, levels at baseline of VWF and FVIII >30 U/dL have us a high likelihood to achieve normal levels at the end of pregnancy; thus specific anti-hemorrhagic prophylaxis is seldom required. Women with basal level <20 U/dL usually have a poor increase since most of these women carry mutations associated with increased VWF clearance or are compound heterozygous for different VWF mutations; that prevent the achievement of satisfactory hemostatic levels. While women with mutations associated with increased clearance show a full, albeit transitory correction of their hemostatic deficiency after desmopressin administration, compound heterozygous need replacement therapy because they do not respond well to this agent. Patients with abnormal VWF:RCo/VWF:Ag ratio at baseline (e.g. <0.6), typically associated with type 2 VWD, maintain the abnormality throughout pregnancy and VWF:RCo usually does not attain safe levels ?50 U/dL. These women require replacement therapy with VWF-FVIII concentrates. Delayed post-partum bleeding may occur when replacement therapy is not continued for some days. Tranexamic acid may be useful at discharge to avoid excessive lochia.

Castaman, Giancarlo

2013-01-01

244

Salim Rashid - John von Neumann and Scientific Method - Journal of the History of Ideas 68:3  

Microsoft Academic Search

This paper interprets John von Neumann's views on the proper role of mathematics in science, with attention to its implications for economics. The evolution of von Neumann's thought over his lifespan, an examination of which is greatly aided by some self-conscious appraisals of von Neumann himself, suggests that von Neumann ended by taking a very pragmatic approach to the use

Salim Rashid

2007-01-01

245

Eine Untersuchung über die Zellteilungsaktivität bei Axolotl-Larven und bei Larven von Triton punctatus, nebst Versuch mit Bestrahlung von ultraviolettem Licht und konstantem elektrischem Licht  

Microsoft Academic Search

Es wurden Untersuchungen angestellt über den normalen Zellteilungsrhythmus bei Larven vonTriton punctatus undAxolotln. Diese Untersuchungen betrafen 5 Versuchsreihen, deren Ergebnisse in Abb. 1 bis 5 zu finden sind. Dazu kommt ferner eine Versuchsreihe mit konstantem elektrischem Licht ganztägig (Abb. 6), drei mit elektrischem Licht von 6–18 Uhr und Dunkel von 18-6 Uhr. Das Ergebnis der letzten drei Versuche zeigt bloß

Thydsen Meinertz

1963-01-01

246

Guidelines for the diagnosis and management of von Willebrand disease in Italy.  

PubMed

von Willebrand disease (vWD) is a bleeding disorder caused by quantitative (type 1 and 3) or qualitative (type 2) defects of von Willebrand factor (vWF). The molecular basis of type 2 and 3 vWD are now known and those of type 1 vWD are being understood. Phenotypic diagnosis is based on the measurements of plasma and platelet vWF, of the ability of vWF to interact with platelet receptors and the analysis of the multimeric structure of vWF. Due to the heterogeneity of vWF defects and the variables that interfere with vWF levels, a correct diagnosis of types and subtypes may sometimes be difficult but is very important for therapy. The aim of treatment is to correct the dual defects of haemostasis, i.e. abnormal intrinsic coagulation expressed by low levels of factor VIII (FVIII) and abnormal platelet adhesion. Desmopressin is the treatment of choice in patients with type 1 vWD, who account for approximately 70% of cases, because it corrects FVIII-vWF levels and the prolonged bleeding time (BT) in the majority of these patients. In type 3 and in severe forms of type 1 and 2 vWD patients, desmopressin is not effective and it is necessary to resort to plasma concentrates containing FVIII and vWF. Treated with virucidal methods, these concentrates are effective and safe, but they cannot always correct BT defect. Platelet concentrates or desmopressin can be used as adjunctive treatments when poor correction of BT after plasma concentrate treatment is associated with continued bleeding. PMID:12199668

Federici, A B; Castaman, G; Mannucci, P M

2002-09-01

247

The influence of detergents on the skin (A clinical and biochemical study)  

Microsoft Academic Search

Zusammenfassung Der Einfluß einer Reihe von Detergentien auf die Haut wurde in verschiedenen Weisen untersucht: Bestimmung des Gehaltes an freien Aminosäuren in Waschwasser, nach dem Waschen der Haut mittels einer Waschmaschine; Untersuchung des Einflusses der Detergentien auf den Gehalt an freien Sulphydrylgruppen in Keratin; Bestimmung des Einflusses der Detergentien auf die Permeabilität excidierter Haut; Läppchenproben und Immersionsproben. Auf Grund dieser

G. Smeenk

1969-01-01

248

Quantitative Logic Programming Revisited  

Microsoft Academic Search

Uncertainty in Logic Programming has been investigated since about 25 years, publishing papers dealing with various approaches\\u000a to semantics and different applications. This paper is intended as a first step towards the investigation of uncertainty in\\u000a Constraint Functional Logic Programming. We revise an early proposal, namely van Emden’s Quantitative Logic Programming [22], and we improve it in two ways. Firstly,

Mario Rodríguez-artalejo; Carlos A. Romero-díaz

2008-01-01

249

Quantitation in echocardiography  

Microsoft Academic Search

Imaging of the heart is the predominant approach to cardiovascular diagnosis in current practice. Of the wide variety of cardiac\\u000a imaging techniques available, echocardiography is one of the most widely used. Standard methods of quantitation of M-mode\\u000a and two-dimensional echocardiograms yield reproducible, accurate measurements of cardiac chamber, wall, and great vessel dimensions.\\u000a Qualitative analysis of valvular appearance and motion permits

David J. Skorton; Steve M. Collins

1987-01-01

250

Quantitative social science  

NASA Astrophysics Data System (ADS)

General concepts for the quantitative description of the dynamics of social processes are introduced. They allow for embedding social science into the conceptual framework of synergetics. Equations of motion for the socioconfiguration are derived on the stochastic and quasideterministic level. As an application the migration of interacting human populations is treated. The solutions of the nonlinear migratory equations include limit cycles and strange attractors. The empiric evaluation of interregional migratory dynamics is exemplified in the case of Germany.

Weidlich, W.

1987-03-01

251

Ernst von Glasersfeld's Radical Constructivism and Truth as Disclosure  

ERIC Educational Resources Information Center

In this essay Clarence Joldersma explores radical constructivism through the work of its most well-known advocate, Ernst von Glasersfeld, who combines a sophisticated philosophical discussion of knowledge and truth with educational practices. Joldersma uses Joseph Rouse's work in philosophy of science to criticize the antirealism inherent in…

Joldersma, Clarence W.

2011-01-01

252

Die Verwertbarkeit von Xylit als Nahrungskohlenhydrat und seine Verträglichkeit  

Microsoft Academic Search

Zusammenfassung Die Verwertung von per os gegebenem Xylit wird durch das Auftreten osmotisch bedingter Durchfälle infolge der langsamen Resorption begrenzt. Die Verhältnisse liegen hier analog wie bei Sorbit, Mannose, Xylose und anderen Kohlenhydraten. 10% Xylit im Futter werden symptomlos vertragen und im Stoffwechsel calorisch verwertet, wie aus Wachstumskurven, Protein-Efficiency und Fortpflanzung hervorgeht. Auch die Verfütterung wesentlich höherer Xylitdosen bedingt keine

W. Kieckebuch; W. Gziem; K. Lang

1961-01-01

253

Bifurcation analysis of an infinite array of von Karman Streets  

Microsoft Academic Search

This research investigates the behavior of an infinite array of (inverse) von Karman streets. Primary motivation is to model the wake dynamics in large fish schools. Ignoring the fish we focus on the dynamic interaction of multiple wakes. In particular, we investigate the problem of fluid transport between adjacent vortex streets for its relevance to understanding the transport of oxygen

Babak Ghaemi Oskouei; Eva Kanso; Paul K. Newton

2008-01-01

254

Successful Treatment of Von Zumbusch Pustular Psoriasis with Infliximab  

Microsoft Academic Search

Background: Von Zumbusch pustular psoriasis is a severe, generalized form of psoriasis. Patients may also suffer from systemic complications, such as fever, arthropathy, congestive heart failure, and infections, which can ultimately prove fatal. Generalized pustular psoriasis can often be recalcitrant, making treatment difficult. Objective: The purpose of this study was to demonstrate the efficacy of infliximab in treating generalized pustular

Jennifer T. Trent; Francisco A. Kerdel

2004-01-01

255

Messung der Turbulenz und von Turbulenzkomponenten mit Hilfe der Koronaentladung  

Microsoft Academic Search

Zusammenfassung Es werden Meßergebnisse zum Existenzbereich der Korona mitgeteilt bei Parametern, die für die anemometrische Verwendung der Korona passend gewählt wurden. Für eine Entladung in strömendem Gas wird der Einfluß der Strömungsgeschwindigkeit auf den Koronastrom untersucht und verschiedene Wirkungen werden quantitativ getrennt. Die obere Grenzfrequenz des Koronaanemometers wird abgeschätzt. An Hand des Verlaufs der anemometrischen Steilheit in Abhängigkeit von der

Wilhelm Fucks

1954-01-01

256

Von Glaserfeld`s Radical Constructivism: A Critical Review  

Microsoft Academic Search

We explore Ernst von Glaserfelds radical constructivism, its criticisms, and our own thoughts on what it promises for the reform of science and mathematics teaching. Our investigation reveals that many criticisms of radical constructivism are unwarranted; nevertheless, in its current cognitivist form radical constructivism may be insufficient to empower teachers to overcome objectivist cultural traditions. Teachers need to be empowered

Michael D. Hardy

1997-01-01

257

Über den chemischen Sinn der Miracidien von Fasciola hepatica  

Microsoft Academic Search

Die Miracidien von Fasciola hepatica reagieren positiv chemotaktisch gegenüber Galba truncatula. Eine genaue Angabe der maximalen Entfernung, in der diese als phobisch zu bezeichnende Reaktion auftritt, ist wegen der je nach der Situation wechselnden Diffusionsbedingungen der Reizstoffe nur schwer möglich. In der hier verwendeten Versuchsanordnung gelang eine Anlockung aus 15 cm Entfernung. Galba truncatula systematisch nahestehende Arten locken die Miracidien

Walter Neuhaus

1953-01-01

258

Orientierung von Lasius fuliginosus Latr. an einer Gabelung der Geruchsspur  

Microsoft Academic Search

Zusammenfassung Das Aufspaltungsverhältnis der futtersuchenden Arbeiterinnen vonLasius fuliginosus an einer Gabelung der Geruchsspur wird im Laborversuch durch das Mengenverhältnis der auf die zwei Schenkel aufgetragenen Spursubstanz bestimmt. Auch im Freiland kann dieses Prinzip wirksam sein, wird jedoch bei erfahrenen Arbeiterinnen offenbar durch optische Orientierung überlappt.

W. Hangartner

1969-01-01

259

Zur Ganggeschwindigkeit von Uhren auf der rotierenden Erde  

Microsoft Academic Search

ALBERT EINSTEINS Bemerkung von 1905, daß eine am Erdäquator aufgestellte Unruh-Uhr etwas langsamer liefe als eine gleichartige, an einem der Erdpole befindliche Uhr, wird durch einen entgegenwirkenden Gravitationseffekt gerade aufgehoben, so daß alle an beliebigen Orten auf Meeresniveau befindlichen Uhren gleichschnell gehen: Die kinematische Zeitverzögerung der mit der Erddrehung bewegten Uhr erweist sich als genau entgegengesetzt gleich der Gangbeschleunigung derselben

Gustav Richter

1984-01-01

260

Alexander von Humboldt: The explorer and the scientist  

Microsoft Academic Search

On June 5, 1799 Alexander von Humboldt, explorer and scientist, left La Coruña in Spain to go to Cumaná, Venezuela. On August 3, 1804 he arrived again in Bordeaux, France. The paper deals with five aspects of this famous journey: The itinerary of the American journey; Scientific aims: Humboldt's journeys and scientific activities were two sides of the same coin;

Eberhard Knobloch

2006-01-01

261

Der Schwefelgehalt von Sulfitsprit und Spritsorten anderen Ursprungs  

Microsoft Academic Search

Zusammenfassung Die Gesamtschwefelgehalte verschiedener Sulfitspritproben und einiger Sprit-Sorten anderen Ursprungs wurden mit der früher von uns beschriebenen „Lampen” Methode bestimmt. Gleichzeitig wurde die Verteilung des im Sulfitsprit enthaltenen Schwefels in den Fraktionen bei einer einfachen Destillation untersucht. Der Mittelwert des Gesamtschwefelgehalts der untersuchten rohen Sulfitspritmuster betrug 95 µg\\/100 ml, derjenige der rohen methanolfreien Sulfitspritproben 47 µg\\/100 ml. Der Gesamtschwefelgehalt der

Risto J. Peltonen; P. Neuenschwander; Heikki Suomalainen

1956-01-01

262

Strategische Ausrichtung und Innovationstätigkeit von KMU im Raum Jena  

Microsoft Academic Search

Das vom Bundesministerium für Bildung und Forschung (BMBF) geförderte Projekt KompNet2011 – Erfolgsfaktoren regionaler Innovationsnetze – untersucht die strategische Ausrichtung sowie die Innovationsaktivitäten von kleinen und mittelständischen Unternehmen (KMU) in der Region Jena. Für die 225 Befragungsteilnehmer stellt die Qualitätsführerschaft die wichtigste Strategie dar: Fast 80% weisen ihr eine hohe bzw. sehr hohe Bedeutung zu. Allerdings belegt der Datensatz auch

Katharina Kaps; Silko Pfeil; Thomas Sauer; Matthias-Wolfgang Stoetzer

2010-01-01

263

Quantum Correlations Induced by Local von Neumann Measurement  

NASA Astrophysics Data System (ADS)

We study the total quantum correlation, semiquantum correlation and joint quantum correlation induced by local von Neumann measurement in bipartite system. We analyze the properties of these quantum correlations and obtain analytical formula for pure states. The experimental witness for these quantum correlations is further provided and the significance of these quantum correlations is discussed in the context of local distinguishability of quantum states.

Zhao, Ming-Jing; Zhang, Ting-Gui; Li, Zong-Guo; Li-Jost, Xianqing; Fei, Shao-Ming; Zhong, De-Shou

2013-07-01

264

Untersuchung der Lebensqualität nachdorsoventraler Stabilisierung von Wirbelkörperfrakturen desthorakolumbalen Übergangs  

Microsoft Academic Search

Zusammenfassung Fragestellung. Aufgrund der höheren mechanischen Stabilität hat die kombinierte dorsoventrale Stabilisierung von Frakturen des thorakolumbalen Übergangs in den letzten Jahren zunehmend an Bedeutung gewonnen. Bislang liegen nur wenige Daten zum postoperativen Verlauf nach einer dorsoventralen Instrumentierung vor. Unklar ist insbesondere, welche Auswirkungen sich auf die Lebensqualität ergeben.Zielsetzung dieser Untersuchung war es,die allgemeine gesundheitsbezogene Lebensqualität nach einer dorsoventralen Stabilisierung des

D. Briem; W. Linhart; W. Lehmann; M. Bullinger; V. Schoder; N. M. Meenen; J. Windolf; J. M. Rueger

2003-01-01

265

In-vitro-Beurteilungsparameter von Beta-Laktamring-Antibiotika  

Microsoft Academic Search

Zusammenfassung Die übliche mikrobiologische Prüfung neuer ß-Laktam-Antibiotika wird durch die Untersuchung der minimalen Hemmkonzentration einer großen Anzahl von meist frisch isolierten Bakterien gegenüber der Substanz im Vergleich mit älteren Substanzen durchgeführt. Dadurch bekommt man ein Bild darüber, ob eine verbesserte Wirksamkeit der „neuen“ Substanz gegeben ist. Man hat aber keine Gewißheit, ob alle Mechanismen, die für die Aktivität einer Substanz

B. Wiedemann

1978-01-01

266

Innovationskooperationen und Wissenstransfer von Unternehmen im Raum Jena  

Microsoft Academic Search

Die im Rahmen des vom Bundesministerium für Bildung und Forschung (BMBF) geförderten Projektes KompNet2011 - Erfolgsfaktoren regionaler Innovationsnetze - durchgeführte Befragung untersucht die Innovationskooperationen sowie Wissenstransferaktivitäten von schwerpunktmäßig kleinen und mittleren Unternehmen (KMU) in der Region Jena. Die Studie konzentriert sich auf drei Aspekte: Mit welcher Intensität werden die verschiedenen Transferkanäle für die Übertragung des Wissens zwischen den kooperierenden Partnern

Katharina Kaps; Silko Pfeil; Thomas Sauer; Matthias-Wolfgang Stoetzer

2011-01-01

267

Von Willebrand's disease with spontaneous platelet aggregation induced by an abnormal plasma von Willebrand factor.  

PubMed Central

We have investigated and characterized the abnormalities in four unrelated patients with von Willebrand's disease (vWd) who have (a) enhanced ristocetin-induced platelet aggregation (RIPA) at low ristocetin concentrations, (b) absence of the largest plasma von Willebrand factor (vWf) multimers, and (c) thrombocytopenia. The platelet-rich plasma of these patients aggregates spontaneously without the addition of any agonists. When isolated normal platelets are resuspended in patient plasma spontaneous aggregation occurs; however, the patients' plasmas did not induce platelet aggregation of normal washed formalinized platelets. When the patients' platelets are suspended in normal plasma, spontaneous aggregation is not observed. The spontaneous platelet aggregation (SPA) is associated with dense granule secretion as measured by ATP release and alpha granule release as measured by beta-thromboglobulin and platelet factor 4 release. The SPA is totally inhibited by 5 mM EDTA, prostaglandin I2, and dibutryl cyclic AMP, while it is only partially inhibited by 1 mM EDTA, acetylsalicylic acid, or apyrase. A monoclonal antibody directed against glycoprotein Ib (GPIb) and/or a monoclonal antibody against the glycoprotein IIb/IIIa (GPIIb/IIIa) complex totally inhibits the SPA. The vWf was isolated from the plasma of one of these patients. The purified vWf induced platelet aggregation of normal platelets resuspended in either normal or severe vWd plasma, but the vWf did not induce platelet aggregation of normal platelets resuspended in afibrinognemic plasma. Sialic acid and galactose quantification of the patient's vWf revealed approximately a 50% reduction compared with normal vWf. These studies indicate that a form of vWd exists, which is characterized by SPA that is induced by the abnormal plasma vWf. The SPA is dependent on the presence of plasma fibrinogen, and the availability of the GPIb and the GPIIb/IIIa complex. In this variant form of vWd the abnormal vWf causes enhanced RIPA, SPA, and thrombocytopenia. Images

Grainick, H R; Williams, S B; McKeown, L P; Rick, M E; Maisonneuve, P; Jenneau, C; Sultan, Y

1985-01-01

268

Quantitative biomedical mass spectrometry  

NASA Astrophysics Data System (ADS)

The scope of this contribution is an illustration of the capabilities of isotope dilution mass spectrometry (IDMS) for quantification of target substances in the biomedical field. After a brief discussion of the general principles of quantitative MS in biological samples, special attention will be paid to new technological developments or trends in IDMS from selected examples from the literature. The final section will deal with the use of IDMS for accuracy assessment in clinical chemistry. Methodological aspects considered crucial for avoiding sources of error will be discussed.

de Leenheer, Andrép; Thienpont, Linda M.

1992-09-01

269

Zelltyp-spezifische Mikroanalyse von Arabidopsis thaliana-Blättern  

NASA Astrophysics Data System (ADS)

Im ersten Teil der Arbeit wurden Strategien zur Analyse von Transkripten erarbeitet. Die ersten Versuche zielten darauf ab, in mit Glaskapillaren genommenen Einzelzellproben verschiedener Gewebeschichten RT-PCR durchzuführen, um spezifische Transkripte nachweisen zu können. Dies gelang für eine Reihe von Genen aus verschiedenen Pflanzenspezies. Dabei konnten sowohl Transkripte stark wie auch schwach exprimierter Gene nachgewiesen werden. Für die Erstellung von Gewebe-spezifischen Expressionsprofilen war es notwendig, die in vereinigten Zellproben enthaltene mRNA zunächst zu amplifizieren, um eine ausreichende Menge für Arrayhybridisierungen zu erhalten. Vor der Vermehrung wurde die mRNA revers transkribiert. Es wurden daran anschließend verschiedene Amplifikationsstrategien getestet: Die neben Tailing, Adapterligation und anderen PCR-basierenden Protokollen getestete Arbitrary-PCR hat sich in dieser Arbeit als einfache und einzige Methode herausgestellt, die mit so geringen cDNA-Mengen reproduzierbar arbeitet. Durch Gewebe-spezifische Array-hybridisierungen mit der so amplifizierten RNA konnten schon bekannte Expressionsmuster verschiedener Gene, vornehmlich solcher, die an der Photosynthese beteiligt sind, beobachtet werden. Es wurden aber auch eine ganze Reihe neuer offensichtlich Gewebe-spezifisch exprimierter Gene gefunden. Exemplarisch für die differentiell exprimierten Gene konnte das durch Arrayhybridisierungen gefundene Expressionsmuster der kleinen Untereinheit von Rubisco verifiziert werden. Hierzu wurden Methoden zum Gewebe-spezifischen Northernblot sowie semiquantitativer und Echtzeit-Einzelzell-RT-PCR entwickelt. Im zweiten Teil der Arbeit wurden Methoden zur Analyse von Metaboliten einschließlich anorganischer Ionen verwendet. Es stellte sich heraus, daß die multiparallele Methode der Gaschromatographie-Massenspektrometrie keine geeignete Methode für die Analyse selbst vieler vereinigter Zellinhalte ist. Daher wurde auf Kapillarelektrophorese zurückgegriffen. Eine Methode, die mit sehr kleinen Probenvolumina auskommt, eine hohe Trennung erzielt und zudem extrem geringe Detektionslimits besitzt. Die Analyse von Kohlenhydraten und Anionen erfordert eine weitere Optimierung. Über UV-Detektion konnte die K+-Konzentration in verschiedenen Geweben von A. thaliana bestimmt werden. Sie lag in Epidermis und Mesophyll mit ca. 25 mM unterhalb der für andere Pflanzenspezies (Solanum tuberosum und Hordeum vulgare) publizierten Konzentration. Weiter konnte gezeigt werden, daß zwölf freie Aminosäuren mittels einer auf Kapillarelektrophorese basierenden Methode in vereinigten Zellproben von Cucurbita maxima identifiziert werden konnten. Die Übertragung der Methode auf A. thaliana-Proben muß jedoch weiter optimiert werden, da die Sensitivität selbst bei Laser induzierter Fluoreszenz-Detektion nicht ausreichte. Im dritten und letzten Teil der Arbeit wurde eine Methode entwickelt, die die Analyse bekannter wie unbekannter Proteine in Gewebe-spezifischen Proben ermöglicht. Hierzu wurde zur Probennahme mittels mechanischer Mikrodissektion eine alternative Methode zur Laser Capture Microdissection verwendet, um aus eingebetteten Gewebeschnitten distinkte Bereiche herauszuschneiden und somit homogenes Gewebe anzureichern. Aus diesem konnten die Proteine extrahiert und über Polyacrylamidgelelektrophorese separariert werden. Banden konnten ausgeschnitten, tryptisch verdaut und massenspektrometrisch die Primärsequenz der Peptidfragmente bestimmt werden. So konnten als Hauptproteine im Mesophyll die große Untereinheit von Rubisco sowie ein Chlorophyll bindendes Protein gefunden werden. Die in dieser Arbeit entwickelten und auf die Modellpflanze Arabidopsis thaliana angewandten Einzelzellanalysetechniken erlauben es in Zukunft, physiologische Prozesse besser sowohl räumlich als auch zeitlich aufzulösen. Dies wird zu einem detaillierteren Verständnis mannigfaltiger Vorgänge wie Zell-Zell-Kommunikation, Signalweiterleitung oder Pflanzen-Pathogen-Interaktionen führen. The subject of this thesis was the analys

Brandt, Stephan Peter

2002-04-01

270

Factor VIII-von Willebrand Factor Binding Defects in Autosomal Recessive von Willebrand Disease Type Normandy and in Mild Hemophilia A  

Microsoft Academic Search

This concise review is focused on genetic, molecular and clinical aspects of von Willebrand disease (VWD) type 2N and of mild hemophilia A due to mutations impairing FVIII-von Willebrand factor (VWF) interactions. Missense mutations in the VWF gene impairing the binding to FVIII do not impair the structure of VWF multimers nor the ability of VWF to aggregate platelets but

Marc Jacquemin

2009-01-01

271

Einfache Decarbonylierungen und stereoselektive Oxidationen von Cyclohexadienen und Cyclohexenen  

NASA Astrophysics Data System (ADS)

Zusammenfassend konnte im Rahmen dieser Arbeit das Synthesepotential von Cyclohexadienen und Cyclohexenen deutlich erweitert werden. Die Darstellung der 1-Alkylcyclohexa-2,5-dien-1-carbonsäuren erfolgte mittels Birch-Reduktion in flüssigem Ammoniak und anschließender Umsetzung der intermediär entstehenden Dianionen mit Alkylhalogeniden. So konnte ausgehend von verschiedenen Benzoesäurederivaten eine Reihe interessanter Cyclohexadiene in sehr guten Ausbeuten synthetisiert werden. Erstmals gelangen säurekatalysierte Decarbonylierungen von Cyclohexadiencarbonsäuren, was die einfache Synthese substituierter Aromaten in ausgezeichneten Ausbeuten ermöglichte. In dieser Arbeit wird der Reaktionsmechanismus vorgestellt, welcher durch den Nachweis von Kohlenmonoxid in der Gasphase der Reaktionslösung durch IR-Spektroskopie untermauert wird. Bei der säurekatalysierten Umsetzung von 3-alkylsubstituierten Cyclohexadien-carbonsäuren entstanden neben den erwarteten Aromaten Lactone in ca. 50% Ausbeute. Schließlich zeigen die untersuchten Singulettsauerstoff-En-Reaktionen, der im ersten Teil dargestellten Cyclohexadiene und Lactone, durchweg hohe Regioselektivitäten und lieferten durch elektrostatische Wechselwirkungen und konformative Effekte zum Teil sehr gute Diastereoselektivitäten. Die auxiliarkontrollierte Photooxygenierungen von Cyclohexenon welches mit verschiedenen Weinsäureestern ketalisiert wurde, zeigten jedoch keine bevorzugte p-Facialität des Singulettsauerstoffs. In this dissertation thesis it was possible to extend the synthetical potential of cyclohexadienes and cyclohexenes with partially newly developed and very efficient synthetic pathways. The alkylcyclohexadiene carboxylic acids were synthesized in good yields via well known Birch-reduction procedure in liquid ammonia from a broad variety of substituted benzoic acid derivatives. A wide range of alkylhalides were subsequently added to the resulting dianion. We were able to decarbonylize the cyclohexadienes through acid catalyses, which leads to ipso-substituted aromatics in excellent yields. The study presents the postulated mechanism, which is supported by the proof of carbon monoxide in the gas phase of the reactionmixture with IR-spectroscopy. When 3-alkylsubstituted cyclohexadiene carboxylic acids were subjected to the acid catalyses they gave lactones in up to 50% yield as side products of the aromatization product.The cyclohexadienes and lactones were used as substrates in singlet oxygen-en-reactions with photochemically induced singulet oxygen. The products showed high regioselectivitiy and partially high diastereoselectivity which is caused by electrostatic interaction and conformativ effects of the reaction intermediates. Experiments to induce auxiliary controlled photooxygenations of cyclohexenones, which were ketalysed with different chiral tartaric acid esters leaded to poor diastereoselectivity and a diverse mixture of isomers.

Vorndran, Katja Marianne

2002-01-01

272

[Effect of von Willebrand factor and endothelin-1 on formation of thrombotic status in patients with ischemic heart disease].  

PubMed

In 44 patients with ischemic heart disease (IHD) and 35 healthy subjects we studied cascade mechanism of platelets activation by von Willebrand factor (vWF), and interrelationship of platelet aggregation, level of vWF, and endothelial dysfunction. The latter was estimated by severity of vasoconstriction determined basing on endothelin-1 levels. Quantitative assessment of platelet aggregation revealed differences in aggregation capacity between healthy subjects and patients with IHD. Of particular importance was absence of spontaneous aggregation in healthy subjects. It was shown that in IHD patients influence of vWF resulted in augmentation and convergence of activating signal. Positive correlation was found in patients with IHD between elevation of levels of vWF, endothelin-1, and spontaneous and induced platelet aggregation activity. Interrelationship was revealed between character of IHD course and degree of elevation of the studied markers. PMID:23548423

Sokolov, E I; Grishina, T I; Shtin, S R

2013-01-01

273

A simple method for the estimation of yeast-growth in hydrocarbon-substrates by determination of turbidity  

Microsoft Academic Search

Zusammenfassung Es wird eine cinfache und schnelle Methode zur Bestimmung der Zellkonzentration in kohlenwasserstoffhaltigen Kulturflüssigkeiten beschrieben. Zur Abtrennung der Kohlenwasserstoffe wird die Probe nach Zusatz von Teepol zentrifugiert, danach die Zellkonzentration durch Trübungsmessung bestimmt.

H. Katinger

1970-01-01

274

A screening method for the simultaneous determination of putrescine, cadaverine, histamine, spermidine and spermine in fish by means of high pressure liquid chromatography of their 5-dimethylaminonaphthalene-l-sulphonyl derivatives  

Microsoft Academic Search

Zusammenfassung Eine einfache und schnelle Methode für die Extraktion, Derivatisierung und Bestimmung von Putrescin, Cadaverin, Histamin, Spermidin und Spermin als 5-Dimethylaminonaphthalin-1-sulfonyl-Derivate mit Hilfe der Hochdruck-Flüssigchromatographie (HPLC).

Jan Rosier; Carlos Van Peteghem

1988-01-01

275

ATP determination with the Tricarb scintillation counter  

Microsoft Academic Search

Zusammenfassung Die Arbeit beschreibt eine neue Technik zur Bestimmung geringster Mengen von ATP (10–11 Mol und weniger) mit der Luciferin-Luciferase-Methode. Die dabei erzeugten Impulse werden mit einem Scintillationszähler gemessen.

E. Tal; S. Dikstein; F. G. Sulman

1964-01-01

276

Quantitative SPECT/CT.  

PubMed

Conventional nuclear medical imaging uses radiopharmaceuticals labeled by single-photon emitters such as Tc-99m, I-123, or I-131 in vivo. Classical clinical examples are the study of bone metabolism by bone scintigraphy with the Tc-99m-labeled polyphosphonates or of iodine transport into the thyroid gland using Tc-99m-pertechnetate. With single-photon emission-computed tomography (SPECT), the distribution of these radiopharmaceuticals within the human body is three-dimensionally visualized. Contrary to positron emission tomography (PET), current SPECT technology does not allow the quantification of regional values of radioactivity tissue concentration as SPECT images are grossly compromised by artifacts caused by photon scatter and attenuation. With the advent of hybrid imaging systems combining a SPECT camera with an X-ray computerized (CT) scanner in one gantry, reliable corrections for these artifacts seem possible, allowing truly quantitative SPECT. PMID:23179886

Ritt, Philipp; Kuwert, Torsten

2013-01-01

277

Quantitative evanescent microwave microscopy  

NASA Astrophysics Data System (ADS)

A vast variety of measurement techniques with high spatial resolution exist. However, a nondestructive technique that provides reliable, sensitive measurements of the complex electrical impedance with high spatial resolution was lacking. I contributed to the development of such a novel microscope, namely scanned evanescent microwave probe (SEMP). We developed experimental and theoretical methods for the evaluation of microwave complex impedance, which allows the quantitative imaging of the complex microwave dielectric constant (for insulators) and resistivity (for conductors) on a submicron length scale. In order to improve the spatial resolution and reduce the sample or tip damages, we also developed a means of distance regulation. With future improvement of the technique, resolutions approaching 20 nm may be expected. The microscope allows the measurement of variations in sample electronic properties on microscopic length scales. We demonstrated the capability to image samples varying from superconducting structures, semiconductors to ferroelectric materials. Such microscopes should find broad applications in various scientific areas and the semiconductor industry.

Duewer, Frederick William

2000-10-01

278

Quantitative evolutionary design  

PubMed Central

The field of quantitative evolutionary design uses evolutionary reasoning (in terms of natural selection and ultimate causation) to understand the magnitudes of biological reserve capacities, i.e. excesses of capacities over natural loads. Ratios of capacities to loads, defined as safety factors, fall in the range 1.2-10 for most engineered and biological components, even though engineered safety factors are specified intentionally by humans while biological safety factors arise through natural selection. Familiar examples of engineered safety factors include those of buildings, bridges and elevators (lifts), while biological examples include factors of bones and other structural elements, of enzymes and transporters, and of organ metabolic performances. Safety factors serve to minimize the overlap zone (resulting in performance failure) between the low tail of capacity distributions and the high tail of load distributions. Safety factors increase with coefficients of variation of load and capacity, with capacity deterioration with time, and with cost of failure, and decrease with costs of initial construction, maintenance, operation, and opportunity. Adaptive regulation of many biological systems involves capacity increases with increasing load; several quantitative examples suggest sublinear increases, such that safety factors decrease towards 1.0. Unsolved questions include safety factors of series systems, parallel or branched pathways, elements with multiple functions, enzyme reaction chains, and equilibrium enzymes. The modest sizes of safety factors imply the existence of costs that penalize excess capacities. Those costs are likely to involve wasted energy or space for large or expensive components, but opportunity costs of wasted space at the molecular level for minor components.

Diamond, Jared

2002-01-01

279

Quantitative Proteomics of Lymphocytes  

PubMed Central

Lymphocytes are the best-studied higher eukaryote cells. In this report, quantitative relationships of the protein components in resting cell, blast cell and plasma cell types are evaluated. The comparison of these cell types leads to the conclusion that resting cells synthesize about one-twentieth of the protein species as compared to blast cells. Blast cells seem to be metabolically the most robust lymphocyte type. Plasma cells are geared towards synthesis of one main product (antibody in B plasma cells), while most of the synthesis of other protein species (including those for housekeeping and repair) decreases as the messages decay. Although the data presented in this communication allow a meaningful comparison of three cell populations, they are far from providing a full picture. Both silver staining and radiofluorography depict only proteins of high or intermediate abundance. Silver staining misses most proteins present at <10 000 copies/cell, while radiofluorography misses all those proteins with slow turnover (and those with no methionine residue in their sequence). The detection of 1100 spots in the blast cell-related radiofluorograph includes visualization of some 97–99% of protein mass, but some 3900 polypeptide species in the remaining 1–3% of protein mass will pass undetected. This protein mass (0.7–2 pg) reflects some 2500–7500 copies of each of those 3900 polypeptide species that are present in the cell below the detection limit. The work emphasizes that full understanding of cellular function can be achieved only if quantitative aspects of cell inventory are considered.

2003-01-01

280

Marshall-Stickler phenotype associated with von Willebrand disease  

SciTech Connect

We report on 6 individuals from three different kindreds with Marshall-Stickler (MS) phenotype, with characteristic orofacial abnormalities, arthropathy, deafness, and eye findings, all of whom were discovered to have a mild bleeding diathesis and coagulation-study findings consistent with mild von Willebrand disease (vWD). MS syndrome has been linked in some cases to the type II procollagen gene (COL2A1) on chromosome 12q, and to the collagen XI gene (COL11A2) on chromosome 6. The von Willebrand factor (vWF) is encoded by a 180-Kb gene located on the short arm of chromosome 12. This is the first reported association of these two disorders. 26 refs., 5 figs., 1 tab.

MacDonald, M.R.; Baker, K.S.; Schaefer, G.B. [Univ. of Nebraska Medical Center, Omaha, NE (United States)

1997-01-20

281

von Willebrand disease and cardiopulmonary bypass: a case report.  

PubMed

The anesthetic management of patients undergoing cardiac surgery on cardiopulmonary bypass can be challenging. Contact of blood with extracorporeal surfaces results in altered coagulational integrity and increased risk of bleeding. Patients with preexisting bleeding disorders are particularly vulnerable. In this article we discuss the anesthetic management of a patient with von Willebrand disease (vWD) undergoing mitral valve replacement on cardiopulmonary bypass. vWD describes a number of different von Willebrand factor disorders, associated with variable degrees of bleeding, which require an individualized approach. The extent of the surgery, the patient-specific vWD coagulopathy, and clinical indicators guided our therapy, which included desmopressin, cryoprecipitate, and vWF/Factor VIII concentrate. PMID:23513326

Teppone-Martin, Oxana L; Zhao, Manxu; Norris, Teresa E

2013-02-01

282

Water Experiments Related To The "Von Karman Sodium" Dynamo Project  

NASA Astrophysics Data System (ADS)

The purpose of the "Von Karman Sodium" (V.K.S.) experiment is to study the "Dynamo Effect," namely the spontaneous generation of magnetic field in a flow of electrically conducting fluid. The device has been built at CEA / Cadarache, in collaboration with CEA / Saclay, Ecole Normale Superieure de Lyon and Ecole Normale Superieure de Paris. It consists of a cylindrical vessel, filled with liquid Sodium, in which two coaxial rotating disks induce a Von-Karman type flow. Several experimental runs have taken place since June 2000. In order to optimize the V.K.S. set-up, a half-scale water prototype has also been built. It has allowed us to measure mean velocity profiles, as well as pressure fluctuations and mechanical power dissipation. We have observed that under certain circumstances the mean component of the turbulent flow can undergo a global bifurcation.

Marie, L.; Bourgoin, M.; Petrelis, F.; Roy, J.; Burguete, J.; Chiffaudel, A.; Daviaud, F.; Fauve, S.; Odier, P.; Pinton, J.-F.

2002-07-01

283

Diagnosis and management of von Willebrand disease in Spain.  

PubMed

The correct diagnosis and classification of Von Willebrand disease (VWD) is important for therapy and genetic counseling but is made difficult due to the variability of its clinical expression and limitations of laboratory methods. A national registry of VWD patients has been initiated in Spain. The results of a concise survey on the diagnosis of VWD show the frequency of VWD is fivefold greater in Spain than that expected from epidemiological studies in other European countries; this may result from overdiagnosis and/or a higher prevalence of VWD. These results clearly reinforce the need for the Spanish VWD registry. A consensus guideline for optimal treatment of VWD is being elaborated in Spain. Desmopressin (DDAVP) is the choice of treatment in responsive VWD patients. Von Willebrand factor concentrates (VWF/factor VIII) are used in individuals nonresponsive to DDAVP, when DDAVP is contraindicated, or in VWD types 2B and 3. PMID:22102193

Batlle, Javier; Perez-Rodriguez, Almudena; Pinto, Joana Costa; Fraga, Esther Loures; Rodriguez-Trillo Tch, Angela; Fernanda Lopez-Fernandez, Maria

2011-11-18

284

Diagnosis of von Willebrand disease in South Island, New Zealand.  

PubMed

New Zealand is a small country of two islands and 4 million people, of which 1 million reside in the South Island. Canterbury Health Laboratories provides laboratory services to the whole of South Island and lower parts of North Island. There are 155 Von Willebrand disease (VWD) patients in our South Island database, of which 17 have type 2 and 3 have type 3 VWD. A brief overview of diagnostic services for VWD being followed in our region is detailed in this article. We strive continually to advance the repertoire of diagnostic tests. We also present an analysis of our experience with a flow-based functional Von Willebrand factor assay. The VWD patients are managed by hemostasis team members, who also provide screening and educational input to affected families. The Haemophilia Foundation of New Zealand is an active patient support group providing education and support both directed individually and in the group setting, through residential educational camps. PMID:22102199

Rajagopal, Rajeev; Smith, Mark P

2011-11-18

285

Treatment of acquired von Willebrand syndrome in childhood.  

PubMed

A 3-1/2-year-old male with no personal or family history of bleeding disorders presented with abdominal distension, epistaxis, and anemia (hemoglobin 8.2 g/dL). A magnetic resonance imaging scan of the abdomen demonstrated a mass arising from the left kidney. Preoperative laboratory studies revealed a prolonged activated partial thromboplastin time of 49.2 seconds, a normal prothrombin time of 12.4 seconds, and a platelet count of 230?000/?L. Further testing revealed factor VIII (FVIII) activity of 16%, factor IX (FIX) activity of 74%, von Willebrand factor (VWF) activity of 12%, VWF antigen activity of 31%, and decreased high-molecular-weight VWF multimers consistent with acquired von Willebrand syndrome (AVWS). What is the best treatment for this child? PMID:23878141

Callaghan, Michael U; Wong, Trisha E; Federici, Augusto B

2013-07-22

286

Autosomal dominant von Willebrand disease type 2M.  

PubMed

von Willebrand disease (VWD) type 2M is a distinct entity and clearly differs from type 1. The genotype-phenotype correlation for cases with ristocetin cofactor activity (RCo)/antigen (Ag) ratios <0.60 is clear, whereas the von Willebrand factor (VWF):collagen binding (CB)/VWF:Ag ratio is normal in VWD 2M. Typical laboratory features of VWD type 2 M are decreased ristocetin-induced platelet aggregation in the presence of a normal or near normal VWF multimeric pattern on a low-resolution agarose gel, a poor response to desmopressin (DDAVP) of VWF:RCo, and a good response of both VWF:CB and VWF:Ag to DDAVP. The phenotypic definition of VWD type 2M may need to be more stringent and should be the subject of an international standardization initiative. PMID:19506360

Hermans, Cedric; Batlle, Javier

2009-06-08

287

[Carl von Bönninghausen--a forgotten homoeopath and his studies].  

PubMed

A lot of physicians practised homoeopathy and dedicated their lives to the method of Samuel Hahnemann, but most of them seem to have been forgotten. By tracing the life of one of them it can be shown how one can learn more about those people and find documents that shed some light on their lives and actions. Carl von Bönninghausen was the son of the famous lay homoeopath Clemens Maria Franz von Bönninghausen. Due to the fact that he married the adoptive daughter of Mélanie Hahnemann some aspects of his life were already known. But he himself had never been the focus of research. Firstly, his life is described with the help of newly found documents. Secondly, notices accidentally found in patient journals show how Carl started as a homoeopath. PMID:20506732

Baschin, Marion

2009-01-01

288

High dimensional Bernstein-von Mises: simple examples  

PubMed Central

In Gaussian sequence models with Gaussian priors, we develop some simple examples to illustrate three perspectives on matching of posterior and frequentist probabilities when the dimension p increases with sample size n: (i) convergence of joint posterior distributions, (ii) behavior of a non-linear functional: squared error loss, and (iii) estimation of linear functionals. The three settings are progressively less demanding in terms of conditions needed for validity of the Bernstein-von Mises theorem.

Johnstone, Iain M.

2010-01-01

289

Von Mises' potential flow wave equation and nonlinear analog gravity  

NASA Astrophysics Data System (ADS)

Von Mises’ nonlinear second-order wave equation for the velocity potential in the case of an irrotational, compressible and barotropic classical perfect fluid is connected to the analog gravity formalism. It is shown that while the standard acoustic metric, built on a certain background, remains central in the higher-order perturbative scheme, at full nonlinear level it plays a less relevant role. Possible applications both for simulations and experiments are discussed.

Cherubini, C.; Filippi, S.

2011-12-01

290

John von Neumann and Klaus Fuchs: an Unlikely Collaboration  

Microsoft Academic Search

I discuss the origin of the idea of making a fusion (hydrogen) bomb and the physics involved in it, and then turn to the design\\u000a proposed for one by the unlikely collaborators John von Neumann and Klaus Fuchs in a patent application they filed at Los\\u000a Alamos in May 1946, which Fuchs passed on to the Russians in March 1948,

Jeremy Bernstein

2010-01-01

291

Von Willebrand factor, ADAMTS13, and thrombotic thrombocytopenic purpura  

Microsoft Academic Search

Von Willebrand factor (vWF), a glycoprotein critical for supporting platelet adhesion and aggregation at sites of vessel injury, exists in the plasma as a series of multimers. Recent studies have shown that a metalloprotease cleaves endothelial vWF to a series of multimers. A deficiency of the protease activity due to autoimmune IgG inhibitors or genetic mutations is associated with thrombotic

Han-Mou Tsai

2002-01-01

292

Über Reaktionen von Titan(IV) in wasserfreiem Medium  

Microsoft Academic Search

Die Reaktionen von TiIV mit einer Reihe organischer Reagentien in konz. Schwefelsäure, in Dimethylformamid und Methanol wurden analytisch bewertet. In wasserfreiem Medium kann das phenolische und enolische Hydroxyl, dessen Protonen bei der Reaktion abgespalten werden, als funktionsanalytische Gruppe für TiIV angesehen werden. Polyphenole mit o-Dihydroxylgruppierung gehören auch in wasserfreiem Medium zu den empfindlichsten Reagentien auf TiIV. Man kann die Titanreaktion

Lumír Sommer

1959-01-01

293

von Hippel-Lindau disease: A clinical and scientific review  

PubMed Central

The autosomal dominantly inherited disorder von Hippel–Lindau disease (VHL) is caused by germline mutations in the VHL tumour suppressor gene (TSG). VHL mutations predispose to the development of a variety of tumours (most commonly retinal and central nervous system haemangioblastomas, clear cell renal carcinoma and phaeochromocytomas). Here, we review the clinical and genetic features of VHL disease, briefly review the molecular pathogenesis and outline clinical management and tumour surveillance strategies.

Maher, Eamonn R; Neumann, Hartmut PH; Richard, Stephane

2011-01-01

294

Über die Körpertemperaturen und den Wärmehaushalt von Apis mellifica  

Microsoft Academic Search

Die Körpertemperaturen von Bienen (Apis mellifica) wurden an Einzeltieren innerhalb und außerhalb des sozialen Verbandes mit Thermoelementen geringer Wärmekapazität (2,68·10-6 cal·grd-1) und unwesentlicher Wärmeableitung (3,5·10-7 cal·grd-1·sec-1) bestimmt. Bei der Sammeltätigkeit liegt die Thoraxtemperatur der Tänzerinnen außerhalb des Stockes durchschnittlich 10° über der Umgebung. Im Stock hat sie einen etwas höheren Betrag. Bei Erreichen einer Temperaturzone um 36° tritt eine Regulation

Harald Esch

1960-01-01

295

Zur Thermodynamik binärer Mischungen von Komponenten annähernd gleichen Molvolumens  

Microsoft Academic Search

Aus den experimentellen Meßdaten der vorangehenden Arbeit1 wurden die integralen freienGibbsschen Zusatzenergien pro Mol Mischung berechnet, auf Grund von ?Gz\\/x·(1-x)-Diagrammen diskutiert und mit der Theorie der Theorie der streng regulären Mischung sowie mit dem Zellmodell nachI. Prigogine undV. Mathot verglichen. Die ?Gz\\/x·(1-x)-Kurven zeigen bei mittleren Konzentrationen eine Durchkrümmung, die nach Größe und Richtung im Sinne der Theorie der streng regulären

F. Kohler; A. Neckel

1956-01-01

296

Untersuchungen über die Biologie von Ustilago violacea (Pers.) Fuck  

Microsoft Academic Search

1.In einer einfachen Nährlösung zeigte der untersuchte Stamm von Ustilago violacea f. Melandrii nur mit Saponin als Kohlenstoffquelle einigermaßen befriedigendes Wachstum.2.Steigende Saponinkonzentrationen bis zu 5% üben keinen hemmenden Einfluß auf das Wachstum des Pilzes aus.3.Kohlenstoffquellen wie Arabinose, Sorbit, Mannit, Lävulose, Glucose, Mannose, Saccharose, Maltose und Salicin, die für sich allein und auch in Kombinationen unter sich für den Pilz ungenügend

S. Blumer

1937-01-01

297

Konzentrationsprofile von Putrescin und Cadaverin in beimpftem vakuumverpacktem Rindfleisch  

Microsoft Academic Search

Zusammenfassung VerschiedeneLactobacillus-, Staphylococcus-undStreptococcus-Stämme wurden auf ihre Fähigkeit geprüft, in vakuumverpacktem Fleisch Putrescin und Cadaverin zu bilden. Während einer sechswöchigen Lagerung bei 4 °C wurden die Proben in regelmäßigen Abständen sensorisch bewertet und ihr pH-Wert bestimmt. Den Amingehalt ermittelten wir mit Hilfe der Capillar-Gaschromatographie. Die Aminkonzentrationen blieben bis zum deutlichen Verderb am Ende der sechsten Woche im Bereich der Anfangswerte von

Jana Slemr; Gundula Ritter

1984-01-01

298

The Radon-Nikodym theorem for von neumann algebras  

Microsoft Academic Search

Let ? be a faithful normal semi-finite weight on a von Neumann algebraM. For each normal semi-finite weight ? onM, invariant under the modular automorphism group ? of ?, there is a unique self-adjoint positive operatorh, affiliated with the sub-algebra of fixed-points for ?, such that ?=?(h·). Conversely, each suchh determines a ?-invariant normal semi-finite weight. An easy application of

Gert K. Pedersen; Masamichi Takesaki

1973-01-01

299

Genotype-phenotype correlation in von Hippel-Lindau syndrome  

Microsoft Academic Search

The von Hippel-Lindau (VHL) syndrome (OMIM 193300) is an autosomal dominant disorder caused by deletions or mutations in a tumor suppressor gene on human chromosome 3p25. It is characterized clinically by vascular tumors including benign hemangioblastomas of the cerebellum, spine, brain stem and retina. Clear-cell renal cell carcinoma is a frequent cause of death, occurring in up to 70% of

Christopher A. Friedrich

2001-01-01

300

Spontaneous hemothorax in patients with von Recklinghausen’s disease  

Microsoft Academic Search

Spontaneous massive intrathoracic bleeding is rare except for the rupture of aortic aneurysm or pleural adhesions in association\\u000a with pneumothorax. We encountered two cases of critical massive hemothorax in patients with von Recklinghausen's disease (type\\u000a I neurofibromatosis). Case 1; a 59-year-old female suddenly experienced severe back pain followed by syncope and shock. The\\u000a hemothorax was caused by a bleeding of

Takashi Miura; Yozo Kawano; Masao Chujo; Michiyo Miyawaki; Hiromu Mori; Katsunobu Kawahara

2005-01-01

301

Beiträge zur Frage der Wirtsfindung des Miracidiums von Fasciola Hepatica  

Microsoft Academic Search

1.Die Miracidien von Fasciola hepatica sind (positiv) rheotaktisch.2.Sie zeigen positive oder negative Chemotaxis je nach der Natur der im Wasser gelösten Stoffe. Bestimmte Stoffe wirken aktivitätssteigernd (stimulierend).3.Die optischen Reaktionen sind topisch in gleichmäßig beleuchteten Bezirken, phobisch an einer Hell-Dunkelgrenze. Bei schwachen und mittleren Intensitäten sind die Tiere positiv phototaktisch, bei hohen Lichtintensitäten dagegen negativ phototaktisch.4.Aus 12–16 cm Entfernung werden die

Walter Neuhaus

1941-01-01

302

Von Gierke's Disease Adopts an Orphan (and Its Partner)  

NSDL National Science Digital Library

The enzyme glucose-6-phosphatase is critical for maintaining fasting blood sugar levels by increasing hepatic glucose production. Its absence in patients with von Gierke’s disease leads to severe hypoglycemia and abnormal accumulation of glycogen (glycogenosis) in the liver. New players that control the expression of glucose-6-phosphatase have been identified that may provide insight into this metabolic disorder, as well as type 2 diabetes.

Alan Cheng (Ann Arbor;University of Michigan Medical Center REV); Alan R. Saltiel (Ann Arbor;University of Michigan Medical Center REV)

2009-02-17

303

Die Gesundheit von Kindern und Jugendlichen in Deutschland  

Microsoft Academic Search

Zusammenfassung  \\u000a Die aktuelle epidemiologische Datenlage zur Gesundheit von Kindern und Jugendlichen offenbart die Notwendigkeit einer repräsentativen\\u000a Gesundheitserhebung für die 0- bis 17-Jährigen. Ein über mehrere Jahre entwickeltes Konzept für einen Kinder- und Jugendgesundheitssurvey\\u000a wurde in einer einjährigen Pilotphase mit 1630 Kindern und Jugendlichen getestet. Die dabei gewonnenen Erfahrungen sowie Gutachterempfehlungen\\u000a werden in einem im Jahr 2003 beginnenden Gesundheitssurvey für ca.

B.-M. Kurth; K. E. Bergmann; A. Dippelhofer; H. Hölling; P. Kamtsiuris; W. Thefeld

2002-01-01

304

Einjahresergebnisse nach Implantation von faltbaren Acryllinsen (IOPTEX ACR 360)  

Microsoft Academic Search

\\u000a Zusammenfassung  In einer prospektiven klinischen Studie wurden 25 Acryllinsen vom Typ IOPTEX ARC 360 implantiert; über die Einjahresergebnisse\\u000a wird berichtet, wobei 21 der 25 Patienten nachuntersucht werden konnten. Die Sehschärfe nach einem Jahr war mit 0,71 (SD =\\u000a 0,221) im Vergleich zur postoperativen Sehschärfe von 0,72 (SD = 0,203) stabil, ein behandlungsbedürftiger Nachstar ist zum\\u000a Untersuchungszeitpunkt nicht aufgetreten, Dezentrierungen sind 4mal

E. Alzner; A. Mistlberger; G. Grabner

1996-01-01

305

The substantial impact of von Willebrand disease on menstruation  

Microsoft Academic Search

von Willebrand disease (vWd) is the most common of all congenital bleeding disorders with an estimated prevalence of 1–3% in the general population. However, the gynecological complications have not been thoroughly described.Objective: To compare the clinical and quality of life aspects of vWd in menstruating women in relation to a cohort of menstruating women in the general population.Methods: A patient

P. A. Kouides; P. Burkart; P. D. Phatak; J. Porter; L. Peacock; C. Braggins; C. Cox; L. Belling; D. Michalovic; F. Howard

1998-01-01

306

von Willebrand Disease in the Pediatric and Adolescent Population  

Microsoft Academic Search

Recent studies indicate that bleeding disorders, particularly von Willebrand disease (VWD) is more prevalent than previously thought in adolescents with menorrhagia. Menorrhagia management in undiagnosed disorders of hemostasis may be associated with unwanted risks and complications. The prevalence of symptomatic VWD in the pediatric primary care setting appears to be 0.11% (95% CI, 0.04–0.25%). Studies evaluating the prevalence of VWD

Sameh Mikhail; Peter Kouides

2010-01-01

307

Paternal origin of new mutations in Von Recklinghausen neurofibromatosis  

Microsoft Academic Search

VON Recklinghausen neurofibromatosis (NF-1)1-4 is a common autosomal dominant disorder. The estimated new mutation rate (1 x 10-4) is one of the highest for a human disorder1. Here we report that in 12 of 14 families we have analysed, the new mutation is of paternal origin. This result is similar to that recently obtained for retinoblastoma5,6. In other genetic disorders

D. Jadayel; P. Fain; M. Upadhyaya; M. A. Ponder; S. M. Huson; J. Carey; A. Fryer; C. G. P. Mathew; D. F. Barker; B. A. J. Ponder

1990-01-01

308

Molecular and Cellular Biology of von Willebrand Factor  

Microsoft Academic Search

von Willebrand factor (VWF) is a plasma protein that performs 2 main functions in hemostasis: it mediates platelet adhesion\\u000a to the injured vessel wall, and it carries and protects coagulation factor VIII. VWF is synthesized through a multistep process\\u000a in endothelial cells and megakaryocytes as a very large polymer composed of identical disulfide-linked 250-kd sub-units. In\\u000a endothelial cells,VWF not only

Cécile V. Denis

2002-01-01

309

Heimüberwachung („home monitoring“) von Kindern und Jugendlichen: Vorschläge für die praktische Anwendung  

Microsoft Academic Search

Zusammenfassung  Umfangreiche ambulante Betreuungsstrukturen, immer leistungsfähigere Technik und nicht zuletzt das Bedürfnis von Eltern, auch\\u000a chronisch kranke Kinder im häuslichen Milieu betreuen zu wollen, stellt an Heimüberwachungssysteme höhere Anforderungen.\\u000a \\u000a Schwierigkeiten bereiten Indikationsstellung, Dauer der Anwendung sowie die Auswahl der jeweils benötigten Geräte.\\u000a \\u000a \\u000a Die vorliegende Leitlinie zur Heimüberwachung von Kindern und Jugendlichen wurde im Sinne von formal bewerteten („evidence level“) Aussagen der

T. Erler; U. Beyer; B. Hoch; G. Jorch; K. Klementz; A. Kramer; E. Paditz; C. F. Poets; L. Wessel; A. Wiater

2009-01-01

310

Der Differenzierungsgrad von Chondrozyten und ihre Vorbehandlung mit „platelet-derived-growth-factor“  

Microsoft Academic Search

Zusammenfassung  \\u000a Derzeitige Methoden für die gesicherte Reparation von artikulären Knorpeldefekten sind noch nicht etabliert. In der vorliegenden\\u000a Studie habe wir das Potential von artikulären Knorpelzellen, perichondralen Zellen und Zellen der costochondralen Ruhezone\\u000a untersucht, neuen Knorpel zu bilden, nachdem diese Zellen in resorbierbare Gewebeträger inkorporiert und in Muskelpouche von\\u000a Nacktmäusen implantiert wurden. In-vitro-Studien haben gezeigt, dass der „platelet derived growth factor-BB“

C. H. Lohmann; Z. Schwartz; G. G. Niederauer; B. D. Boyan

2000-01-01

311

von Willebrand factor: the old, the new and the unknown.  

PubMed

von Willebrand factor (VWF) is a protein best known from its critical role in hemostasis. Indeed, any dysfunction of VWF is associated with a severe bleeding tendency known as von Willebrand disease (VWD). Since the first description of the disease by Erich von Willebrand in 1926, remarkable progress has been made with regard to our understanding of the pathogenesis of this disease. The cloning of the gene encoding VWF has allowed numerous breakthroughs, and our knowledge of the epidemiology, genetics and molecular basis of VWD has been rapidly expanding since then. These studies have taught us that VWF is rather unique in terms of its multimeric structure and the unusual mechanisms regulating its participation in the hemostatic process. Moreover, it has become increasingly clear that VWF is a more all-round protein than originally thought, given its involvement in several pathologic processes beyond hemostasis. These include angiogenesis, cell proliferation, inflammation, and tumor cell survival. In the present article, an overview of advances concerning the various structural and functional aspects of VWF will be provided. PMID:23020315

Lenting, P J; Casari, C; Christophe, O D; Denis, C V

2012-12-01

312

[Factor VIII (von Willebrand antigen) in patients with acquired thrombocytopathies].  

PubMed

Factor VIII/von Willebrand antigen (VA), part of the molecule of plasma factor VIII, realizes the interaction between platelets and vascular endothelium and the triggering of primary hemostasis. The modern diagnostics and treatment of the complicated acquired thrombocytopathies are impossible without the investigation on the concentration of factor VIII/von Willebrand antigen. The immune coagulation method used allows the objective, exact and fast determination of VA--referent values have been developed in healthy subjects. The patients with blastic leukosis studied--28 and with chronic myeloleukemia--18, all with severe endogenous complicated thrombocytopathy, functionally and biochemically confirmed, showed normal values of VA/von Willebrand antigen. On the contrary, a slightly elevated VA was established in patients with diabetes with no vascular-degenerative syndrome, corresponding to the activation of platelet functions and to enhanced adhesiveness in particular, contributing to thrombotic complications. The data obtained are discussed in connection with the etiopathogenesis of the separate kinds of thrombocytopathies and the necessity of substitutive therapy. PMID:3111097

Genova, V; Baleva, M; Nikolov, K

1987-01-01

313

The British Interplanetary Society - Val Cleaver and Wernher von Braun  

NASA Astrophysics Data System (ADS)

This article is concerned with the early relationship between Wernher von Braun and the British Interplanetary Society (BIS). The BIS/Wernher von Braun/Val Cleaver correspondence files located here at the US Space & Rocket Center in Huntsville, Alabama are unparalleled. As one reads the stimulating comments between Cleaver and von Braun, the need to share their thoughts prevails. Following is an excerpt from one letter that whets ones appetite for more. 10 June 1951 Cleaver writes, “I'm so glad you enjoyed my last letter, and look forward to your promised further contribution to our discussion of the ethics of science in general and astronautics in particu- lar. As regards the one particular point on which you found yourself unable to hold your fire, I should say there are really two distinct issues at stake:. . .” This article attempts to represent the best of the letters as they goad each other on scientific principles, means to prevent wars, and other philosophic ideas.

Willhite, I. P.

314

Über die Verwendung mikrochemischer Nachweise in der Metallographie. I. Mitteilung: Die richtige Erkennung von Schwefelseigerungen  

Microsoft Academic Search

Zusammenfassung  1. Der mikrochemische Sulfidnachweis mittels der Jod-Azidreaktion nachF. Feigl ermöglicht die Identifizierung auch von Spuren von Sulfidschwefel sowohl im Abdruckverfahren nachE. Heyn undO. Bauer als auch in jenem vonR. Baumann.\\u000a \\u000a 2. Der positive Ausfall der Sulfidreaktion nachFeigl an den schwarzen und gelben Flecken, die bei Ausführung eines Sublimatabduruckes erhalten werden, beweisen einwandfrei das\\u000a Vorliegen von sulfidisch gebundenem Schwefel.\\u000a \\u000a \\u000a \\u000a 3. Phosphide

M. Nießner

1930-01-01

315

Die radiochirurgische Therapie mit der Leksell Gamma Einheit in der Behandlung von Aderhautmelanomen  

Microsoft Academic Search

\\u000a Zusammenfassung  Die Radiochirurgie mit der Gamma Einheit, vom Schweden Lars Leksell für die Behandlung von Hirntumoren eingeführt, scheint\\u000a auf Grund ihrer physikalischen Eigenschaften (Emission einer hohen Dosis in einer Sitzung mit scharfem Dosisabfall gegenüber\\u000a gesundem Gewebe) für die Behandlung von Aderhautmelanomen geeignet.\\u000a \\u000a Durch erste positive Erfahrungen von Chinela, Zambrano und Bunge ermutigt, haben wir die neurochirurgische Therapie für die\\u000a Behandlung von

G. Langmann; G. Pendl; O. Schröttner; G. Stücklschweiger; J. Faulborn

1995-01-01

316

Einfache Grauwert-Transferfunktion für die Berechnung von digital rekonstruierten Röntgenbildern  

NASA Astrophysics Data System (ADS)

Das Raycasting ist ein etabliertes Verfahren zur Berechnung von Digital Rekonstruierten Röntgenbildern (DRRs), also auf Basis von CT-Daten approximierten Radiographien, welche die Projektion eines Summationsbilds des 3D-CT-Volumens auf eine zweidimensionale Bildebene darstellen. Die Wirkung eines von einem Raycasting-Strahl durchquerten Voxels auf das Ergebnispixel im DRR kann unter anderem mit Hilfe von Transferfunktionen berechnet werden, die den Grauwert des Voxels in einen Schwächungskoeffizienten für den Strahl umrechnen. Es wird ein einfaches mathematisches Modell für eine solche Transferfunktion vorgestellt, dessen Parametrisierung eng an die klinische Praxis angelehnt ist.

Newe, Axel; Rascher-Friesenhausen, Richard; Peitgen, Heinz-Otto

317

Social Media für Destinationen – Integration von Social-Media-Aktivitäten in den touristischen Kommunikations-Mix  

Microsoft Academic Search

\\u000a Im Social Web werden Menschen vom passiven Konsumenten touristischer Botschaften zu aktiven Gestaltern touristischer Kommunikation\\u000a und zum entscheidenden Faktor effizienter Kommunikation von Marken-Botschaften. Bereits jetzt nutzt mehr als die Hälfte der\\u000a User von Reise-Websites Social Media-Instrumente. Destinationen sollten daher das Potenzial von Social-Web-Tools erkennen\\u000a und diese selbst aktiv zur Kommunikation und Stärkung ihrer Marke nutzen. Eine erfolgreiche Präsenz von Destinations

Reinhard Lanner; Olaf Nitz; Martin Schobert

318

Percutaneous coronary intervention in a patient with von Willebrand's disease presenting with an acute coronary syndrome.  

PubMed

The optimal management strategy for patients with von Willebrand's disease presenting with acute coronary syndromes is unclear. We present a clinical case of percutaneous coronary intervention following an acute coronary syndrome in a man with von Willebrand's disease. Other published case reports are reviewed. The central role of von Willebrand factor in the pathophysiology of acute coronary syndrome and the possible cardioprotective effects of low levels of the protein are discussed. Practical considerations regarding hemostasis and antiplatelet therapy are addressed. Finally, recommendations for the management of patients with von Willebrand's disease presenting with acute coronary syndromes are suggested. PMID:16732061

Macdonald, John; Srinivasan, Manivannan; More, Ranjit

2006-04-01

319

Zur Frage des intraokularen Druckverhaltens nach vitreoretinaler Chirurgie mit Anlegen von Retinektomien  

Microsoft Academic Search

\\u000a Zusammenfassung\\u000a Fragestellung  In der vorliegenden Arbeit soll der Einfluss des intraokularen Druckverhaltens nach Anlegen von Retinektomien im Rahmen von\\u000a vitreoretinalen Eingriffen untersucht werden.\\u000a \\u000a \\u000a \\u000a Methode  In den Jahren 1994 und 1995 wurden bei 22 von insgesamt 210 Patienten mit Netzhautablösung, bei denen vitreoretinale Eingriffe\\u000a vorgenommen worden waren, zusätzlich Retinektomien durchgeführt. Bei diesen 22 Fällen wurden Retinektomien von 90° bis 360°\\u000a erforderlich, da durch

J. Schmidt; L. Hesse; A. Zawia; P. Kroll

1999-01-01

320

Tubular von Hippel-Lindau Knockout Protects against Rhabdomyolysis-Induced AKI.  

PubMed

Renal hypoxia occurs in AKI of various etiologies, but adaptation to hypoxia, mediated by hypoxia-inducible factor (HIF), is incomplete in these conditions. Preconditional HIF activation protects against renal ischemia-reperfusion injury, yet the mechanisms involved are largely unknown, and HIF-mediated renoprotection has not been examined in other causes of AKI. Here, we show that selective activation of HIF in renal tubules, through Pax8-rtTA-based inducible knockout of von Hippel-Lindau protein (VHL-KO), protects from rhabdomyolysis-induced AKI. In this model, HIF activation correlated inversely with tubular injury. Specifically, VHL deletion attenuated the increased levels of serum creatinine/urea, caspase-3 protein, and tubular necrosis induced by rhabdomyolysis in wild-type mice. Moreover, HIF activation in nephron segments at risk for injury occurred only in VHL-KO animals. At day 1 after rhabdomyolysis, when tubular injury may be reversible, the HIF-mediated renoprotection in VHL-KO mice was associated with activated glycolysis, cellular glucose uptake and utilization, autophagy, vasodilation, and proton removal, as demonstrated by quantitative PCR, pathway enrichment analysis, and immunohistochemistry. In conclusion, a HIF-mediated shift toward improved energy supply may protect against acute tubular injury in various forms of AKI. PMID:23970125

Fähling, Michael; Mathia, Susanne; Paliege, Alexander; Koesters, Robert; Mrowka, Ralf; Peters, Harm; Persson, Pontus Börje; Neumayer, Hans-Hellmut; Bachmann, Sebastian; Rosenberger, Christian

2013-08-22

321

Quantitative Seismology, Second Edition  

NASA Astrophysics Data System (ADS)

As recently as 1980, anyone seeking a rigorous treatment of the fundamentals of elastodynamics relevant to the rapidly maturing field of seismology had to delve into a host of primary sources, some of which were rather obscure or difficult to obtain. Classical texts in this field tended to focus on limited topics and to treat some areas either superficially or in excessive depth. Graduate education in the field of seismology tended to reflect local faculty expertise and interests, often with compendia of handwritten notes, inconsistent notation, and variable generality. That situation was dramatically changed with the appearance of the first edition of Quantitative Seismology, a two-volume set that distilled the key foundations of elastodynamics for linear elastic materials into an accessible and satisfyingly thorough presentation of seismological theory. The adoption of a uniform, consistent notation in which many previous contributions were represented was perhaps as great of a contribution to the field as the many conceptual insights revealed by the authors' treatment of the topic. That work has become a disciplinary standard, with tremendous impact on the education of students and the research of advanced practitioners in the field. No subsequent text has supplanted this cornerstone of the discipline, but over time the second volume went out of print and a second edition became necessary.

Lay, Thorne

322

Quantitive DNA Fiber Mapping  

SciTech Connect

Several hybridization-based methods used to delineate single copy or repeated DNA sequences in larger genomic intervals take advantage of the increased resolution and sensitivity of free chromatin, i.e., chromatin released from interphase cell nuclei. Quantitative DNA fiber mapping (QDFM) differs from the majority of these methods in that it applies FISH to purified, clonal DNA molecules which have been bound with at least one end to a solid substrate. The DNA molecules are then stretched by the action of a receding meniscus at the water-air interface resulting in DNA molecules stretched homogeneously to about 2.3 kb/{micro}m. When non-isotopically, multicolor-labeled probes are hybridized to these stretched DNA fibers, their respective binding sites are visualized in the fluorescence microscope, their relative distance can be measured and converted into kilobase pairs (kb). The QDFM technique has found useful applications ranging from the detection and delineation of deletions or overlap between linked clones to the construction of high-resolution physical maps to studies of stalled DNA replication and transcription.

Lu, Chun-Mei; Wang, Mei; Greulich-Bode, Karin M.; Weier, Jingly F.; Weier, Heinz-Ulli G.

2008-01-28

323

Quantitative serum immunoglobulin tests.  

PubMed

What is the test? Immunoglobulins are protein molecules. They contain antibody activity and are produced by the terminal cells of B-cell differentiation known as 'plasma cells'. There are five classes of immunoglobulin (Ig): IgG, IgM, IgA, IgD and IgE. In normal serum, about 80% is IgG, 15% is IgA, 5% is IgM, 0.2% is IgD and a trace is IgE. Quantitative serum immunoglobulin tests are used to detect abnormal levels of the three major classes (IgG, IgA and IgM). Testing is used to help diagnose various conditions and diseases that affect the levels of one or more of these immunoglobulin classes. Some conditions cause excess levels, some cause deficiencies, and others cause a combination of increased and decreased levels. IgD and IgE will not be discussed in this article. PMID:23550242

Loh, Richard K S; Vale, Sandra; McLean-Tooke, Andrew

2013-04-01

324

The UK guidelines for the use of desmopressin in patients with von Willebrand's disease. Von Willebrand Working Party of the United Kingdom Haemophilia Centre Director's Organization.  

PubMed

A document entitled Guidelines for the Diagnosis and Management of von Willebrand's Disease was produced by the von Willebrand Working Party of the United Kingdom Haemophilia Centre Directors' Organization. Under the chairmanship of Dr Beverley Hunt, an independent board of haematologists and anaesthesiologists reviewed the use of a synthetic vasopressin analogue, desmopressin (DDAVP), in the management of patients with von Willebrand's disease. The Advisory Board considered that production of the guidelines was to be applauded, but that the contraindications for DDAVP were imprecisely defined and may thus be misleading. This paper summarizes the Advisory Board's discussion of the suggestions. PMID:9088830

Lethagen, S; Flordal, P; Van Aken, H; Hunt, B J; Cattaneo, M

1997-03-01

325

Quantitative analysis of system coupling  

Microsoft Academic Search

To solve the problem that it is difficult to calculate system coupling in the field of systems science and software engineering, this article discussed quantitative analysis of system coupling. It is difficult to calculate system coupling in the field of system science and software engineering. Consequently, this paper discussed quantitative analysis of system coupling to solve this problem. According to

Yin Zhang; Hua Zhou; Qing Duan; Yun Liao; Junhui Liu; Zhenli He

2011-01-01

326

QUANTITATIVE 15N NMR SPECTROSCOPY  

EPA Science Inventory

Line intensities in 15N NMR spectra are strongly influenced by spin-lattice and spin-spin relaxation times, relaxation mechanisms and experimental conditions. Special care has to be taken in using 15N spectra for quantitative purposes. Quantitative aspects are discussed for the 1...

327

Helping Students Become Quantitatively Literate  

ERIC Educational Resources Information Center

|In recent years, the term "quantitative literacy" has become a buzzword in the mathematics community. But what does it mean, and is it something that should be incorporated into the high school mathematics classroom? In this article, the authors will define quantitative literacy (QL), discuss how teaching for QL differs from teaching a…

Piatek-Jimenez, Katrina; Marcinek, Tibor; Phelps, Christine M.; Dias, Ana

2012-01-01

328

Workshop on quantitative dynamic stratigraphy  

SciTech Connect

This document discusses the development of quantitative simulation models for the investigation of geologic systems. The selection of variables, model verification, evaluation, and future directions in quantitative dynamic stratigraphy (QDS) models are detailed. Interdisciplinary applications, integration, implementation, and transfer of QDS are also discussed. (FI)

Cross, T.A.

1988-04-01

329

Real-World Quantitative Finance  

NASA Astrophysics Data System (ADS)

Although the language of financial theory resembles the language of physics, there are actually very few reliable and accurate principles on which to base a theory of quantitative finance. This talk provides a short guide to the principles and techniques used to build theories of quantitative value in the trading world.

Derman, Emanuel

2002-03-01

330

Quantitative analysis of software architectures  

Microsoft Academic Search

Quantitative analysis of software systems is a critical issue in the development of applications for heterogeneous distributed and mobile systems. It has been recognised that performance analysis should be integrated in the software development life cycle since the early stages. We focus on quantitative analysis of software architectures (SA) and in particular on performance models and languages to represent, evaluate

Simonetta Balsamo; Marco Bernardoand; Vincenzo Grassi

331

Quantitative luminescence imaging system  

NASA Astrophysics Data System (ADS)

The goal of the Measurement of Chemiluminescence project is to develop and deliver a suite of imaging radiometric instruments for measuring spatial distributions of chemiluminescence. Envisioned deliverables include instruments working at the microscopic, macroscopic, and life-sized scales. Both laboratory and field portable instruments are envisioned. The project also includes development of phantoms as enclosures for the diazoluminomelanin (DALM) chemiluminescent chemistry. A suite of either phantoms in a variety of typical poses, or phantoms that could be adjusted to a variety of poses, is envisioned. These are to include small mammals (rats), mid-sized mammals (monkeys), and human body parts. A complete human phantom that can be posed is a long-term goal of the development. Taken together, the chemistry and instrumentation provide a means for imaging rf dosimetry based on chemiluminescence induced by the heat resulting from rf energy absorption. The first delivered instrument, the Quantitative Luminescence Imaging System (QLIS), resulted in a patent, and an R&D Magazine 1991 R&D 100 award, recognizing it as one of the 100 most significant technological developments of 1991. The current status of the project is that three systems have been delivered, several related studies have been conducted, two preliminary human hand phantoms have been delivered, system upgrades have been implemented, and calibrations have been maintained. Current development includes sensitivity improvements to the microscope-based system; extension of the large-scale (potentially life-sized targets) system to field portable applications; extension of the 2-D large-scale system to 3-D measurement; imminent delivery of a more refined human hand phantom and a rat phantom; rf, thermal and imaging subsystem integration; and continued calibration and upgrade support.

Batishko, C. R.; Stahl, K. A.; Fecht, B. A.

332

Inheritance and prevalence of von Willebrand's disease severe form in a Brazilian population  

Microsoft Academic Search

Summary Reviewed data suggest that the prevalence of severe von Wille-brand's disease is influenced by ethnic and geographic factors. In the State of Rio Grande do Sul, Brazil, seven genealogies in which 11 individuals had a severe expression of von Willebrand's disease were localized. These affected subjects had similar laboratory results and all of them seemed to have resulted from

R. R. Fischer; C. Lerner; E. Bandinelli; A. S. K. Fonseca; I. Roisenberg

1989-01-01

333

Über den Mechanismus und die Kinetik der ?-Caprolactam-Polymerisation in Gegenwart von Wasser  

Microsoft Academic Search

Zusammenfassung Die Bildungskinetik des Poly-?-Caprolactams wird experimentell bei 220° in Gegenwart von 0,01, 0,02, 0,04 und 0,08 Mol Wasser und von 0,01 Mol?-Aminocapronsäure pro Mol Gesamtlactam zu Reaktionsbeginn untersucht. Die Meßergebnisse werden in Tabellen und vergleichend in Abbildungen dargestellt und diskutiert.

Fritz Wiloth

1955-01-01

334

Visualisierung analoger Schaltungen durch 3-D Animation von transienten SPICE-Simulationen  

Microsoft Academic Search

Für das Zeichnen analoger Schaltpläne wird oft versucht, die Potentialverteilung in der entsprechenden Schaltung auszunutzen, um eine Platzierung der Bauteile nach abfallendem Potential vorzunehmen. Mit Hilfe von Computerunterstützung gelingt es, eine verallgemeinerte dreidimensionale Platzierungsstrategie anzuwenden, die allein auf Grund der Potentialwerte einer Schaltung die automatische Generierung einer technisch exakten Potentialdarstellung erlaubt. Somit ist es möglich, die Ergebnisse von transienten SPICE-Simulationen

J. Becker; Y. Manoli

2007-01-01

335

Zwischen Neugier und Angst Emotionen und sexuelles Risikoverhalten von Mädchen beim ersten Mal  

Microsoft Academic Search

Zusammenfassung: Jugendliche zeigen riskantes Gesundheitsverhalten als Strategie zur Bewältigung von Entwicklungsaufgaben (Pinquart & Silbereisen, 2004). Sozialkognitive Mo- delle zur Erklärung und Prädiktion von Gesundheitsverhalten betrachten menschliches Ver- halten als Resultat vernunftgesteuerter Prozesse, vernachlässigen allerdings emotionale Faktoren (Pant, 2003). Die vorliegende Studie exploriert Emotionen vor, während und nach dem ersten Geschlechtsverkehr und deren Rolle bei STDs-präventivem Verhalten. 32 Mäd- chen (x

Olivia Kada; Eva Brunner

336

von Willebrand factor and coronary heart disease. Prospective study and meta-analysis  

Microsoft Academic Search

Aims To determine whether circulating von Willebrand factor concentrations are prospectively related to risk of coronary heart disease in the general population. Methods and Results We measured baseline von Willebrand factor values in the stored serum samples of 625 men with major coronary events and in 1266 controls 'nested' in a prospective study of 5661 men aged 40-59 years, recruited

P. H. Whincup; J. Danesh; M. Walker; L. Lennon; A. Thomson; P. Appleby; A. Rumley; G. D. O. Lowe

2002-01-01

337

Autosomal recessive transmission of hemophilia A due to a von Willebrand factor mutation  

Microsoft Academic Search

The differential diagnosis of the genetic bleeding disorders, hemophilia A and von Willebrand disease, is occasionally confounded by the close molecular relationship of coagulation factor VIII and von Willebrand factor (vWF). This report describes the autosomal inheritance of a hemophilia A phenotype due to a mutation of vWF that results in defective factor VIII binding. The proband was a female

Robert J. Wise; Bruce M. Ewenstein; Jed Gorlin; Seth C. Narins; Michael Jesson J; Robert I. Handin

1993-01-01

338

Zum vorkommen pflanzenpathogener viren in gewässern in der umgebung von halle\\/saale (Sachsen?anhalt)  

Microsoft Academic Search

Im Rahmen von Untersuchungen zum Vorkommen pflanzenpathogener Viren in Oberflächengewässern in der Umgebung von Halle\\/Saale (Sachsen?Anhalt) konnten in den Jahren 1986 bis 1992 neben dem tobacco mosaic virus (TMV) und dem tobacco necrosis virus (TNV) wiederholt das grapevine Algerian latent virus (GALV) und das Petunia asteroid mosaic virus (PAMV) gefunden werden. Die letztgenannten Viren waren auch aus dem Boden des

Egon Fuchs; Maria Grüntzig; Ina Auerbach; Ina Einecke; Cornelia Müller; Margit Krägenow

1994-01-01

339

In memory of Eugene (Jen?) von Gothard: a pioneering nineteenth century Hungarian astrophysicist  

NASA Astrophysics Data System (ADS)

Eugene von Gothard was a Hungarian engineer/scientist, instrument-maker and astrophysicist who founded the Herény Astrophysical Observatory in 1881 and carried out pioneering work in astronomical photography and spectroscopy. In this paper we provide biographical material about von Gothard and describe his observatory, before discussing his astronomical observations and the contribution that hemade to the early development of astrophysics.

Vincze, Ildik? J.; Jankovics, István

2012-07-01

340

A Modified Version of Free Orbit-Dimension of von Neumann Algebras  

Microsoft Academic Search

Based on the notion of free orbit-dimension introduced by D. Hadwin and J. Shen [4], we introduce a new invariant on finite von Neumann algebras that do not necessarily act on separable Hilbert space. We show that this invariant is independent on the generating set, and we extend some results in [4] to von Neumann algebras that are not finitely

Don Hadwin; Weihua Li

2008-01-01

341

Tracial gauge norms on finite von Neumann algebras satisfying the weak Dixmier property  

Microsoft Academic Search

In this paper we set up a representation theorem for tracial gauge norms on finite von Neumann algebras satisfying the weak Dixmier property in terms of Ky Fan norms. Examples of tracial gauge norms on finite von Neumann algebras satisfying the weak Dixmier property include unitarily invariant norms on finite factors (type II1 factors and Mn(C)) and symmetric gauge norms

Junsheng Fang; Don Hadwin; Eric Nordgren; Junhao Shen

2008-01-01

342

Die wechselnde Sichtbarkeit des Pyrenoids und die Zoosporen von Chrysochaete britannica  

Microsoft Academic Search

Zusammenfassung Das zweiteilige Pyrenoid der ChrysocapsaleChrysochaete britannica tritt im Leben deutlich, mangelhaft oder gar nicht hervor, was offenbar auf Veränderungen in den Lichtbrechungsverhältnissen der Zellkomponenten beruht, die außer von unbekannten Faktoren auch von der Temperatur beeinflußt werden. Nach Fixierung oder Färbung läßt es sich regelmäßig nachweisen.

Elisabeth Tschermak-Woess

1970-01-01

343

The Fate of Western Civilization: G. H. von Wright's Reflections on Science, Technology, and Global Society  

ERIC Educational Resources Information Center

|This article introduces the central ideas of G. H. von Wright's cultural philosophy concerning the techno-scientific form of life. Georg Henrik von Wright (1916-2003) was best known for his achievements in the field of modal logic and for his association with Ludwig Wittgenstein. However, his work also included a critical analysis of science and…

Heikkero, Topi

2004-01-01

344

Renal involvement in tuberous sclerosis complex and von Hippel–Lindau disease: shared disease mechanisms?  

Microsoft Academic Search

Tuberous sclerosis complex and von Hippel–Lindau disease are distinct autosomal dominant tumor suppressor syndromes that can exhibit similar renal phenotypes and seem to share some signaling pathway components. Similarities exist in the current clinical management of, and the newly identified potential therapeutic approaches for, these conditions. This Review summarizes the pathophysiologic and therapeutic overlap between tuberous sclerosis complex and von

Brian J Siroky; Maria F Czyzyk-Krzeska; John J Bissler

2009-01-01

345

Politikkonvergenz und Politikdiffusion durch Regierungs- und Nichtregierungsorganisationen: ein internationaler Vergleich von Umweltzeichen  

Microsoft Academic Search

Mit dem Vergleich zweier unterschiedlicher Systeme von Umweltzeichen, stellt diese Studie ein Politikinstrument ins Zentrum, das eine sehr viel schnellere Verbreitung gefunden hat als andere Politikinnovationen. Verglichen wird die Diffusion zweier unterschiedlicher Typen von Umweltzeichensystemen: (1) allgemeiner Umweltzeichensysteme wie dem deutschen Blauen Engel und (2) des Zertifizierungsprogramms des Forest Stewardship Council (FSC). Zu Beginn werden drei unterschiedliche Erklärungen für Politikkonvergenz

Kristine Kern; Ingrid Kissling-Näf

2002-01-01

346

Quantitative analysis of 'calanchi  

NASA Astrophysics Data System (ADS)

Three years (2006 - 2009) of monitoring data from two calanchi sites located in the western Sicilian Appennines are analyzed and discussed: the data comes from two networks of erosion pins and a rainfall gauge station. The aim of the present research is to quantitatively analyze the effects of erosion by water and to investigate their relationships with rainfall trends and specific properties of the two calanchi fronts. Each of the sites was equipped with a grid of randomly distributed erosion pins, made of 41 nodes for the "Catalfimo" site, and 13 nodes for the "Ottosalme" site (in light of the general homogeneity of its geomorphologic conditions); the erosion pins consist in 2 cm graded iron stakes, 100 cm long, with a section having a diameter of 1.6 cm. Repeated readings at the erosion pins allowed to estimate point topographic height variations; a total number of 21 surveys have been made remotely by acquiring high resolution photographs from a fixed view point. Since the two calanchi sites are very close each other (some hundred meters), a single rainfall gauge station was installed, assuming a strict climatic homogeneity of the investigated area. Rainfall data have been processed to derive the rain erosivity index signal, detecting a total number of 27 erosive events. Despite the close distance between the two sites, because of a different geologic setting, the calanchi fronts are characterized by the outcropping of different levels of the same formation (Terravecchia fm., Middle-Late Miocene); as a consequence, both mineralogical, textural and geotechnical (index) properties, as well as the topographic and geomorphologic characteristics, change. Therefore, in order to define the "framework" in which the two erosion pin grids have been installed, 40 samples of rock have been analyzed, and a geomorphologic detailed survey has been carried out; in particular, plasticity index, liquid limit, carbonate, pH, granulometric fractions and their mineralogic properties, electrical conductivity and sodium adsorption ratio (SAR), have been characterized. The analysis of the data allows to define relationships between the response of each erosion pin and the erosive rainfall events, the micro-hydrologic of its position and lithotechnical properties of the outcropping rocks. The estimations of the mean annual erosion rate and of the erosivity index, as well as results of the terrain analysis, largely agree with available data from literature observed in similar sites affected by calanchi development. Moreover, the gained results well reflect the differences of the morphologic features and their distribution on the two calanchi fronts; of particular interest is the spatial distribution and variability of piping landforms that markedly influence the development of gullies, specially on "Catalfimo" site, where a high frequency of pipes of different typologies can be detected.

Agnesi, Valerio; Cappadonia, Chiara; Conoscenti, Christian; Costanzo, Dario; Rotigliano, Edoardo

2010-05-01

347

Zur Bestimmung des Formaldehyds in Lebensmitteln  

Microsoft Academic Search

Summary With a modification of the colorimetric method of Buchanan and Schryver formaldehyde can be estimated in food and other material with the same reproducibility and with a higher sensitivity, comparing the method with chromotropic acid. The red color, which is formed by formaldehyde, phenylhydrazine and potassium hexacyanoferrat (III), was identified as 1,5-diphenylformazane. After the usual addition of phosphoric acid

Klement Möhler; Georg Denbsky

1970-01-01

348

Chlorokomplexe von 3 d 5 -Ionen in nichtwäßrigen Lösungen  

Microsoft Academic Search

Die Chlorosysteme von Mn2+ und Fe3+ wurden in Acetonitril (AN), Propandiol-1,2-carbonat (PDC) und Trimethylphosphat (TMP) spektrophotometrisch, potentiometrisch und konduktometrisch untersucht. Folgende Koordinationsformen dürften vorliegen: MnCl2 (inAN, PDC undTMP), [MnCl4]2--(tetraedrisch inAN, oktaedrisch inTMP), [MnCl6]4- (oktaedrisch inPDC undTMP); [FeCl]2+ (tetraedrisch inAN undPDC), [FeCl2]+ (tetraedrisch inTMP), FeCl3 (tetraedrisch inAN undPDC), [FeCl4]- (tetraedrisch inAN, PDC undTMP).

V. Gutmann; W. Lux

1967-01-01

349

Genotoxizität von PhthalatenZur Diskussion über Weichmacher in Kinderspielzeug  

Microsoft Academic Search

Zusammenfassung  \\u000a \\u000a \\u000a Hintergrund und Fragestellung. Gesundheitliche Gefhrdungen durch Weichmacher in Kunststoffen werden insbesondere fr Kinder vielfltig diskutiert. Derivate\\u000a der Phthalate werden Polyvinylchlorid und anderen Plastikmaterialien zugesetzt, um diese elastisch oder formbar zu machen.\\u000a Ziel der vorliegenden Untersuchungen ist es, mgliche genotoxische Einflsse von 2 Vertretern der Stoffgruppe der Phthalate\\u000a an menschlichen Mukosaproben des Oropharynx in vitro zu messen.\\u000a \\u000a \\u000a \\u000a \\u000a \\u000a Patienten und Methodik.

N. H. Kleinsasser; E. R. Kastenbauer; B. C. Wallner; H. Weissacher; U. A. Harréus

2001-01-01

350

Zur Fixierung von radioaktivmarkierten Catecholaminen bei autoradiographischen Untersuchungen  

Microsoft Academic Search

Mäusen wurde radioaktives DOPA — DL-DOPA-[a-14C], DL-DOPA-[ß-T], DL-DOPA-[6-T], DL-DOPA-[2,5,6-T3] — i.p. injiziert. Nach 2 Tagen wurden die Nebennieren entnommen. Zu diesem Zeitpunkt enthalten die Nebennieren Radioaktivität nur noch in Form von Adrenalin und Noradrenalin. Je Tier wurde eine Nebenniere fixiert, während die andere gefriergetrocknet wurde und als Kontrolle diente. Fixationslösung waren 5%iges K2Cr2O7, Orthsche Lösung und Formalin-Calciumchlorid. Nach der Fixation

Klaus Hempel

1965-01-01

351

von Neumann lattices in finite-dimensional Hilbert spaces  

NASA Astrophysics Data System (ADS)

The prime number decomposition of a finite-dimensional Hilbert space reflects itself in the representations that the space accommodates. The representations appear in conjugate pairs for factorization to two relative prime factors which can be viewed as two distinct degrees freedom. These, Schwinger’s quantum degrees of freedom, are uniquely related to a von Neumann lattices in the phase space that characterizes the Hilbert space and specifies the simultaneous definitions of both (modular) positions and (modular) momenta. The area in phase space for each quantum state in each of these quantum degrees of freedom, is shown to be exactly h , Planck’s constant.

Revzen, M.; Khanna, F. C.

2008-07-01

352

von Willebrand factor and cancer: a renewed interest.  

PubMed

Von Willebrand factor (VWF), the largest human plasma protein, is an adhesive multimeric glycoprotein that mediates platelet adhesion to both the subendothelial matrix and endothelial surfaces and acts as a carrier for coagulation factor VIII in the circulation. Besides its essential role in hemostasis, there is growing evidence from the literature that VWF has an additional antitumor effect, mainly by exerting negative modulation on angiogenesis and apoptosis. Current knowledge on the link between VWF and cancer is summarized in this review, based on an analysis of the most important experimental and clinical studies. PMID:23394808

Franchini, Massimo; Frattini, Francesco; Crestani, Silvia; Bonfanti, Carlo; Lippi, Giuseppe

2013-02-08

353

Otto von Guericke and 17th century cosmology  

NASA Astrophysics Data System (ADS)

Otto von Guericke's scientific method was based on reason and experimental science. His cosmology was embedded in theology and can be interpreted as a refutation of Descartes' worldview. He used Nicolaus Cusanus' theory of quantities in order to characterize space. The notion of space has to be distinguished from that of world or heaven. Forces play a crucial role in this respect described by Athanasius Kircher in his "Celestial Journey". Guericke read this work very diligently. In spite of some obvious similarities between Guericke's and Newton's scientific aims and methods there are crucial differences between the scientific convictions and results of these scholars.

Knobloch, Eberhard

354

The Effects of Ristocetin and von Willebrand Factor on Platelet Electrophoretic Mobility  

PubMed Central

Ristocetin will induce the agglutination of platelets in the presence of von Willebrand factor. In previous studies, an electrostatic mechanism was proposed for this phenomenon wherein first the platelet's surface charge is reduced by the binding of ristocetin and then the von Willebrand factor acts as a bridge between platelets. To test this hypothesis, the effects of ristocetin and von Willebrand factor, singly and together, on the electrophoretic mobility of normal, trypsinized, and Bernard-Soulier platelets was measured. Ristocetin alone, at concentrations of 0.5 mg/ml or more, produced a statistically significant reduction in the electrophoretic mobility of fresh or fixed platelets. Control experiments showed that the reduction was not due to changes in the ionic milieu of the solution. Therefore, the decrease in platelet mobility is evidence for binding of ristocetin to the platelet surface. Bernard-Soulier and trypsinized platelets also had reductions in mobility with ristocetin, suggesting that ristocetin binds to the platelet at sites other than the binding site for von Willebrand factor. The presence of plasma from a patient with von Willebrand's disease did not alter the reduction in mobility of normal platelets by ristocetin. However, the reduction was markedly enhanced in the presence of normal plasma. This enhancement did not occur with Bernard-Soulier platelets and was inhibited by anti-Factor VIII/von Willebrand factor antiserum or trypsinization of the platelets. Thus, the enhanced reduction appears to be associated with the binding of von Willebrand factor to the platelet surface. These studies indicate that platelets undergo two changes with ristocetin and von Willebrand factor, both of which facilitate agglutination: reduction in net surface charge and binding of von Willebrand factor, a large molecule which can serve as a bridge between platelets. In parallel studies, bovine von Willebrand factor, without ristocetin, agglutinated and reduced the electrophoretic mobility of normal but not Bernard-Soulier or trypsinized platelets; this indicates a similar mechanism of agglutination.

Coller, Barry S.

1978-01-01

355

An Example of Quantitative Silviculture  

Treesearch

Description: Quantitative silviculture is the application of biological relationships ... this page and attach it to the printout of the article, to retain the full citation information. ... Paper presented at the Tenth Biennial Southern Silvicultural Research ...

356

Quantitative Methods of Edge Detection.  

National Technical Information Service (NTIS)

Most local operators used in edge detection can be modelled by one of two methods: edge enhancement/thresholding and edge fitting. This dissertation presents a quantitative design and performance evaluation of these methods. The design techniques are base...

I. E. Abdou

1978-01-01

357

Experimentelle Bestimmung der stellaren (n,(gamma))-Querschnitte von (sup 148)Sm und (sup 150)Sm und die Konsequenzen fuer den s-Prozess. (Experimental determination of the stellar neutron capture cross sections of (sup 148)Sm and (sup 150)Sm and the consequences for the s-process).  

National Technical Information Service (NTIS)

The Karlsruhe 4(pi)-BaF(sub 2)-detector was upgraded by implementation of an ADC system, consisting of two ADC's for each of the 42 detector modules for determination of the gamma-ray energy and time of flight. A preprocessing option allows for an examina...

K. H. Guber

1993-01-01

358

Quantitative Vs qualitative research methods  

Microsoft Academic Search

Quantitative methods have been widely used because of the fact that things that can be measured or counted gain scientific\\u000a credibility over the unmeasurable. But the extent of biological abnormality, severity, consequences and the impact of illness\\u000a cannot be satisfactorily captured and answered by the quantitative research alone. In such situations qualitative methods\\u000a take a holistic perspective preserving the complexities

M. Lakshman; Leena Sinha; Moumita Biswas; Maryann Charles; N. K. Arora

2000-01-01

359

Quantitative approaches to computational vaccinology  

Microsoft Academic Search

This article reviews the newly released JenPep database and two new powerful techniques for T-cell epitope prediction: (i) the additive method; and (ii) a 3D-Quantitative Structure Activity Relationships (3D-QSAR) method, based on Comparative Molecular Similarity Indices Analysis (CoMSIA). The JenPep database is a family of relational databases supporting the growing need of immunoinformaticians for quantitative data on peptide binding to

Irini A Doytchinova; Darren R Flower

2002-01-01

360

[Bilateral adrenal pheochromocytomas in von Hippel-Lindau disease].  

PubMed

The pheochromocytoma is a medullo-adrenal tumor which develops at the cost of the chromaffin cells. It appears in 11-19% of cases of von Hippel-Lindau's disease (VHL), is often bilateral, and the symptomatology is often crude: arterial hypertension is frequently isolated and unstable, and the classic triad of headache, palpitations and sweating is quite rarely observed. We report four observations of bilateral pheochromocytomas in patients with von Hippel-Lindau's disease (three with phenotype IIA and one with phenotype IIB). The tumor was bilateral during the diagnosis in three cases; in the fourth patient, the attack on the contralateral adrenal gland came two years after the first adrenalectomy. All the patients had undergone an adrenalectomy by open surgery after a short preparation of 48 hours; replacement therapy was begun in each patient. Morbidity was low, and the patients submitted to a prolonged follow-up in order to screen for the onset of future lesions of VHL. PMID:11774764

Touiti, D; Seket, B; Deligne, E; Badet, L; Colombel, M; Dawahra, M; Martin, X; Maréchal, J M; Dubernard, J M

2001-11-01

361

The doubling of von Klitzing's constant h/e^2  

NASA Astrophysics Data System (ADS)

The Hall resistivity is found to become a function of spin. For positive spin, one value is found but for negative sign in the spin, another value occurs. In this way, there is never only one value of the resistivity but there is doubling of values. The value of the von Klitzing's constant is a special case of more general dependence of resistivity on the spin. We investigate the effect of Landau levels. For extreme quantum limit, n=0, the effective charge of the electron becomes (1/2)ge. The fractional charge arises for finite value of the angular momentum. The fractional as well as the integral values of the charge are in full agreement with the experimental data. The generalized constant is h/[(1/2)ge]e which under special conditions becomes h/e2 which is the von Klitzing's constant [1]. [1] K. N. Shrivastava, Phys. Lett. A 113,435(1986); A326,469(2004); Mod. Phys. Lett. 13,1087(1999); 14,1009(2000); AIP Conf. Proc. 909, 43-49(2007); 909.50-56(2007);1017, 422-428(2008);1017,326-330(2008); 1017, 47-56(2008), Proc. SPIE(USA)7155,71552F1-8[7155&_slash;86](2008).

Shrivastava, Keshav

2009-03-01

362

A phase II prospective open-label escalating dose trial of recombinant interleukin-11 in mild von Willebrand disease  

PubMed Central

Summary von Willebrand factor (VWF) is a multimeric glycoprotein that mediates platelet adhesion and is decreased in von Willebrand disease (VWD). 1-8 deamino-d-arginine vasopressin (DDAVP), the most common treatment for VWD, is limited by tachyphylaxis and inconvenience, and in 20% of the patients, unresponsiveness. Recombinant human interleukin-11 (rhIL-11), a gp-130 signalling cytokine with haematopoietic and anti-inflammatory activity, increases VWF antigen and its activity in heterozygous VWF+/? mice and dogs. To determine the biological efficacy and safety of rhIL-11 in non-bleeding human subjects with mild VWD, we conducted a phase II prospective open-label trial of rhIL-11 at 10, 25 and 50 ?g kg?1 subcutaneously (s.c.), given daily for 7 days in nine subjects with mild VWD. VWF and factor VIII (FVIII) levels increased gradually and progressively after s.c. rhIL-11, which was sustained through 7 days of dosing to 1.5- to 3-fold over baseline. Following intravenous DDAVP, 0.3 ?g kg?1, on day 7 there was a further boost in VWF and FVIII levels, suggesting that the mechanism of rhIL-11 differs from that of DDAVP. Platelet VWF mRNA expression measured by quantitative PCR increased from two- to eightfold over baseline, suggesting that the mechanism of rhIL-11 effect may be upregulation of VWF mRNA. VWF and FVIII levels returned to baseline by day 14. rhIL-11 was well tolerated with less than grade-1 hypertension, hypokalaemia and fluid retention. Recombinant IL-11 increases VWF levels in humans with mild VWD, justifying future clinical trials to determine its potential in preventing or reducing bleeding in this patient population.

RAGNI, M. V.; JANKOWITZ, R. C.; CHAPMAN, H. L.; MERRICKS, E. P.; KLOOS, M. T.; DILLOW, A. M.; NICHOLS, T. C.

2011-01-01

363

Establishment and characterization of a new and stable collagen-binding assay for the assessment of von Willebrand factor activity  

PubMed Central

Introduction Laboratory diagnosis of von Willebrand disease (VWD) requires determination of both von Willebrand factor (VWF) protein levels and activity. Current VWF activity tests include the ristocetin cofactor assay and the collagen-binding assay (VWF:CB). The goal of this investigation is to characterize a new collagen-binding assay and to determine its effectiveness in identifying VWD. Methods Analytical studies were carried out to characterize the performance of a new VWF:CB ELISA. Additionally, samples from a normal population were tested as were well-characterized type 1 and type 2 VWD samples. Results Repeatability and within-laboratory precision studies resulted in coefficients of variation (CVs) of ?11%. A linear range of 1–354% (0.01–3.54 IU/mL) was determined, along with a limit of detection and a lower limit of quantitation of 1.6% and 4.0% (0.016 and 0.04 IU/mL), respectively. Samples tested from apparently healthy individuals resulted in a normal range of 54–217% (0.54–2.17 IU/mL). Known VWD type 1 and type 2 samples were also analyzed by the ELISA, with 99% of samples having VWF:CB below the normal reference range and an estimated 96% sensitivity and 87% specificity using a VWF collagen-binding/antigen cutoff ratio of 0.50. Conclusion This new VWF:CB ELISA provides an accurate measure of collagen-binding activity that aids in the diagnosis and differentiation of type 1 from type 2 VWD.

Ni, Y; Nesrallah, J; Agnew, M; Geske, F J; Favaloro, E J

2013-01-01

364

Developing Geoscience Students' Quantitative Skills  

NASA Astrophysics Data System (ADS)

Sophisticated quantitative skills are an essential tool for the professional geoscientist. While students learn many of these sophisticated skills in graduate school, it is increasingly important that they have a strong grounding in quantitative geoscience as undergraduates. Faculty have developed many strong approaches to teaching these skills in a wide variety of geoscience courses. A workshop in June 2005 brought together eight faculty teaching surface processes and climate change to discuss and refine activities they use and to publish them on the Teaching Quantitative Skills in the Geosciences website (serc.Carleton.edu/quantskills) for broader use. Workshop participants in consultation with two mathematics faculty who have expertise in math education developed six review criteria to guide discussion: 1) Are the quantitative and geologic goals central and important? (e.g. problem solving, mastery of important skill, modeling, relating theory to observation); 2) Does the activity lead to better problem solving? 3) Are the quantitative skills integrated with geoscience concepts in a way that makes sense for the learning environment and supports learning both quantitative skills and geoscience? 4) Does the methodology support learning? (e.g. motivate and engage students; use multiple representations, incorporate reflection, discussion and synthesis) 5) Are the materials complete and helpful to students? 6) How well has the activity worked when used? Workshop participants found that reviewing each others activities was very productive because they thought about new ways to teach and the experience of reviewing helped them think about their own activity from a different point of view. The review criteria focused their thinking about the activity and would be equally helpful in the design of a new activity. We invite a broad international discussion of the criteria(serc.Carleton.edu/quantskills/workshop05/review.html).The Teaching activities can be found on the Teaching Quantitative Skills in the Geosciences website (serc.Carleton.edu/quantskills/). In addition to the teaching activity collection (85 activites), this site contains a variety of resources to assist faculty with the methods they use to teach quantitative skills at both the introductory and advanced levels; information about broader efforts in quantitative literacy involving other science disciplines, and a special section of resources for students who are struggling with their quantitative skills. The site is part of the Digital Library for Earth Science Education and has been developed by geoscience faculty in collaboration with mathematicians and mathematics educators with funding from the National Science Foundation.

Manduca, C. A.; Hancock, G. S.

2005-12-01

365

Measurement of von Willebrand factor as the marker of endothelial dysfunction in vascular diseases  

PubMed Central

BACKGROUND: von Willebrand factor is a blood glycoprotein that is required for normal hemostasis. Its level can be increased by endothelial cell damage. HYPOTHESIS: von Willebrand factor is a suitable marker of endothelial dysfunction. METHODS: von Willebrand factor activity was determined by ELISA in patients with acute coronary syndromes, acute stroke and chronic vascular diseases, and was compared with the values of healthy controls. RESULTS: von Willebrand factor activity of patients in each group was significantly higher (P<0.001) than that of the control group. The values of patients with acute coronary syndrome and acute stroke were significantly higher (P<0.05 and P<0.01, respectively) than those of patients with chronic vascular diseases. von Willebrand factor activity was significantly higher in patients with acute coronary syndrome and acute stroke (P<0.05 and P<0.01, respectively) on the sixth day than on admission. CONCLUSIONS: By measuring von Willebrand factor activity, a considerable, significant difference could be found between healthy people and chronic and acute vascular patients. The routine measurement of von Willebrand factor activity in vascular patients as an index of endothelial dysfunction may have clinical importance, because detection of this marker can be a noninvasive way of assisting diagnosis and indicating disease progression.

Horvath, Beata; Hegedus, Dalma; Szapary, Laszlo; Marton, Zsolt; Alexy, Tamas; Koltai, Katalin; Czopf, Laszlo; Wittmann, Istvan; Juricskay, Istvan; Toth, Kalman; Kesmarky, Gabor

2004-01-01

366

[Structure and function of the factor VIII/von Willebrand factor complex].  

PubMed

In the blood plasma factor VIII is bound to the von Willebrand factor. The primary structure of the two proteins were clarified by gene clonation. Factor VIII descends from a precursor protein with 2,351 amino acids by splitting of 19 amino acid residues and is activated by partial proteolysis. In the blood coagulation factor VIII acts as co-factor for the activation of factor X by factor IX in the presence of phospholipids and Ca++ within the intrinsic coagulation system. The formation of the von Willebrand factor takes place by splitting of 22 and 741 amino acid residues, respectively, from pre-pro-von Willebrand factor via pro-von Willebrand factor. The subunits of the von Willebrand factor consist od 2,050 amino acid residues. In the blood plasma the von Willebrand factor is existing as a mixture of multimeres. Receptors of the von Willebrand factor on the thrombocytic membrane are the glycoproteins GPIb and GPIIb/GPIIIa, by means of which the adhesion of thrombocytes at the subendoethelium of the vascular wall and the aggregation of thrombocytes are mediated. PMID:2159676

Müller, G

1990-03-01

367

Von Willebrand Factor permeates small vessels in CADASIL and inhibits smooth muscle gene expression  

PubMed Central

Background and Purpose CADASIL (cerebral autosomal dominant arteriopathy subcortical infarcts and leukoencephalopathy) is a genetic disorder hallmarked by ischemic stroke and vascular dementia. Characteristic pathological changes in the vasculature include thickening of small arteries and accumulation of heterogeneous material within the vessel wall. We tested whether endothelial von Willebrand factor (vWF) accumulates in CADASIL vessels and whether exposure of smooth muscle cells to vWF alters the expression of smooth muscle gene expression. Methods Brain sections obtained at autopsy from six North American CADASIL patients were examined using immunohistochemistry for vWF and IgG. Rat aortic smooth muscle cells (A7R5 cells) were tested for binding to infrared-tag labeled vWF. Finally, A7R5 cells were exposed to vWF, and expression of mature smooth muscle marker genes was analyzed by quantitative reverse transcriptase PCR. Results vWF is expressed in the penetrating arterial walls in all CADASIL samples. IgG, a marker of serum extravasation, was present only in a minority of arterial walls. vWF binds to smooth muscle cells in vitro, and low concentrations of vWF rapidly activate c-fos, EGR, TSP1, and c-myc while specifically inhibiting RNA encoding smooth muscle actin, calponin, and SM22. Conclusions These data demonstrate that vWF, likely produced by the endothelium, permeates the vessel wall of CADASIL brains. Exposure of smooth muscle cells to vWF results in reduction of specific RNAs required for normal vascular homeostasis. This is the first report of accumulation of a protein within CADASIL vessels that inhibits vascular gene expression and implicates a role for vWF beyond hemostasis.

Zhang, Xiaojie; Meng, He; Blaivas, Mila; Rushing, Elisabeth J.; Moore, Brian E.; Schwartz, Jessica; Lopes, M. Beatriz S.; Worrall, Bradford B.; Wang, Michael M.

2011-01-01

368

In-vitro Evaluation von endoskopischer Oberflächenrekonstruktion mittels Time-of-Flight-Kameratechnik  

Microsoft Academic Search

\\u000a Eine der größten Herausforderungen im Kontext von computergestützten Systemen für laparoskopische Eingriffe stellt die intraoperative\\u000a präzise und schnelle Rekonstruktion von Organoberflächen dar. Diese ermöglicht eine Registrierung präoperativer Planungsdaten\\u000a auf die Patientenanatomie zur Einblendung von Ziel- und Risikostrukturen in das Videobild. Vor diesem Hintergrund eröffnet\\u000a die Time-of- Flight (ToF)-Kameratechnik aufgrund der schnellen und dichten 3D-Oberflächenvermessung neue Perspektiven für\\u000a die laparoskopische computerassistierte

A. Groch; S. Hempel; S. Speidel; K. Höller; R. Engelbrecht; J. Penne; A. Seitel; S. Röhl; K. Yung; S. Bodenstedt; F. Pflaum; T. Kilgus; H.-P. Meinzer; J. Hornegger; L. Maier-Hein

369

Langzeitergebnisse des Drainage-Implantates nach Molteno\\/von Denffer bei therapierefraktären Glaukomen  

Microsoft Academic Search

\\u000a Zusammenfassung\\u000a Problemstellung  Bei Glaukom-Augen, die medikamentös und operativ nicht druckreguliert werden konnten oder bereits zur Erblindung geführt haben,\\u000a wurde ein Molteno-Implantat nach von Denffer implantiert.\\u000a \\u000a \\u000a \\u000a Material und Methode  Von 1995 bis 2005 wurde an 21 Augen ein Drainagesystem nach Molteno, modifiziert nach von Denffer, implantiert. Das Alter\\u000a der Patienten lag bei 64 Jahren (15 bis 77 Jahre). Durchschnittlich wurden an diesen Augen

M. Jähne; G. Sulzer

2006-01-01

370

[Biologic artifacts in quantitative EEG].  

PubMed

We studied the influence of five biologic artifacts sources on quantitative EEG (blinking, forced eyes closure, forced jaw closure, tongue movements and pursuit eyes movements) through both visual and spectral analysis, with the purpose of verifying how do these artifacts can be seen in a cartographic way. We found that the spectrums potentials showed the same topographic display that was found through visual analysis. Visual analysis was superior than the quantitative evaluation to recognise the artifacts, as the former preserved the morphological display of the paroxysms. However it is important know how do the potentials are represented in quantitative maps, so that they can be identified as artifacts and not as pathologic EEG activity. PMID:16791367

Anghinah, Renato; Basile, Luis I; Schmidt, Magali T; Sameshima, Koichi; Gattaz, Wagner Farid

2006-06-09

371

Energy Education: The Quantitative Voice  

NASA Astrophysics Data System (ADS)

A serious study of energy use and its consequences has to be quantitative. It makes little sense to push your favorite renewable energy source if it can't provide enough energy to make a dent in humankind's prodigious energy consumption. Conversely, it makes no sense to dismiss alternatives---solar in particular---that supply Earth with energy at some 10,000 times our human energy consumption rate. But being quantitative---especially with nonscience students or the general public---is a delicate business. This talk draws on the speaker's experience presenting energy issues to diverse audiences through single lectures, entire courses, and a textbook. The emphasis is on developing a quick, ``back-of-the-envelope'' approach to quantitative understanding of energy issues. )

Wolfson, Richard

2010-02-01

372

Quantitative Proteome Mapping of Nitrotyrosines  

SciTech Connect

An essential first step in the understanding disease and environmental perturbations is the early and quantitative detection of the increased levels of the inflammatory marker nitrotyrosine, as compared with its endogenous levels within the tissue or cellular proteome. Thus, methods that successfully address a proteome-wide quantitation of nitrotyrosine and related oxidative modifications can provide early biomarkers of risk and progression of disease as well as effective strategies for therapy. Multidimensional separations LC coupled with tandem mass spectrometry (LC-MS/MS) has, in recent years, significantly expanded our knowledge of human (and mammalian model system) proteomes including some nascent work in identification of post-translational modifications. In the following review, we discuss the application of LC-MS/MS for quantitation and identification of nitrotyrosine-modified proteins within the context of complex protein mixtures presented in mammalian proteomes.

Bigelow, Diana J.; Qian, Weijun

2008-02-10

373

Quantitative Analyse und Visualisierung der Herzfunktionen  

Microsoft Academic Search

Die computergestützte bildbasierte Analyse der Herzfunktionen ist mittlerweile Standard in der Kardiologie. Die verfügbaren Produkte erfordern meist ein hohes Maß an Benutzerinteraktion und somit einen erhöhten Zeitaufwand. In dieser Arbeit wird ein Ansatz vorgestellt, der dem Kardiologen eine größtenteils automatische Analyse der Herzfunktionen mittels MRT-Bilddaten ermöglicht und damit Zeitersparnis schafft. Hierbei werden alle relevanten herzphysiologsichen Parameter berechnet und mithilfe von

Anne Sauer; Tobias Schwarz; Nicole Engel; Mathias Seitel; Hannes Kenngott; Carsten Mohrhardt; Dirk Loßnitzer; Evangelos Giannitsis; Hugo A. Katus; Hans-Peter Meinzer

2009-01-01

374

Stochastic von Bertalanffy models, with applications to fish recruitment.  

PubMed

We consider three individual-based models describing growth in stochastic environments. Stochastic differential equations (SDEs) with identical von Bertalanffy deterministic parts are formulated, with a stochastic term which decreases, remains constant, or increases with organism size, respectively. Probability density functions for hitting times are evaluated in the context of fish growth and mortality. Solving the hitting time problem analytically or numerically shows that stochasticity can have a large positive impact on fish recruitment probability. It is also demonstrated that the observed mean growth rate of surviving individuals always exceeds the mean population growth rate, which itself exceeds the growth rate of the equivalent deterministic model. The consequences of these results in more general biological situations are discussed. PMID:17055532

Lv, Qiming; Pitchford, Jonathan W

2006-09-15

375

Appearances of von Meyenburg Complex on Cross Sectional Imaging  

PubMed Central

The von Meyenburg complex (VMC) is an uncommon congenital malformation and is characterized by benign bile duct hamartomas. These are usually discovered incidentally and may represent a diagnostic dilemma when liver metastases are suspected. MRI of VMC shows distinct imaging characteristics, but reporting of lesional contrast enhancement has been inconsistent, whilst microbubble contrast enhanced ultrasound provides ‘real-time’ evaluation of soft tissue vascularity. Given the diagnostic uncertainty over imaging in VMC, biopsy is often recommended as the definitive diagnosis. We report a biopsy proven case of VMC on a background of primary colonic malignancy investigated with ultrasound, contrast enhanced ultrasound, computed tomography CT, and magnetic resonance imaging MRI, and review the key imaging features.

Lung, Phillip F. C.; Jaffer, Ounali S.; Akbar, Nuzhat; Sidhu, Paul S.; Ryan, Suzanne M.

2013-01-01

376

Von Glaserfeld`s Radical Constructivism: A Critical Review  

NASA Astrophysics Data System (ADS)

We explore Ernst von Glaserfelds radical constructivism, its criticisms, and our own thoughts on what it promises for the reform of science and mathematics teaching. Our investigation reveals that many criticisms of radical constructivism are unwarranted; nevertheless, in its current cognitivist form radical constructivism may be insufficient to empower teachers to overcome objectivist cultural traditions. Teachers need to be empowered with rich understandings of philosophies of science and mathematics that endorse relativist epistemologies; for without such they are unlikely to be prepared to reconstruct their pedagogical practices. More importantly, however, is a need for a powerful social epistemology to serve as a referent for regenerating the culture of science education. We recommend blending radical constructivism with Habermas theory of communicative action to provide science teachers with a moral imperative for adopting a constructivist epistemology.

Hardy, Michael D.

377

[Heinrich von Kleist and the true nature of man].  

PubMed

In short-stories, novels and plays, the artist's interpretation of human nature may render the reader valuable insights into the basics of human behaviour. This article is a discussion of a short-story about a fictitious earthquake in Chile, written in 1807 by Heinrich von Kleist (1777-1811). The writer shows how feelings of warmth, friendliness and solidarity come out when a catastrophe reduces the relative importance of man-made rules and regulations. But more sombre sides of human nature also come to the surface in the wake of the disaster, and the writer indicates that even the apparently virtuous Christian morality contains severe traits of cruelty and repressiveness. PMID:9914759

Larsen, O

1998-12-10

378

Coinheritance of severe von Willebrand disease with Glanzmann thrombasthenia.  

PubMed

A 35-years old male patient presented severe bleeding was diagnosed to have type 3 von Willebrand disease (VWD) and carrier for Glanzmann thrombasthenia (GT). Propositus and family members were studied through basic coagulation tests and genomic DNA analysis. Two offspring of the family were diagnosed to have GT through platelet aggregation along with VWD carrier. The patient with VWD was found positive for homozygous truncating mutation R1659X in VWF gene, and all offspring were heterozygous carriers of null allele. Hence, propositus was a carrier of GT with severe type 3 VWD and wife was a carrier of GT. Thus, it is concluded that there is importance of careful studies of patients even from nonconsanguineous families to exclude unusual coinheritance of congenital hemostatic disorders. If single replacement therapy in patient not responding well then probably co-expression of coagulopathies required and multiple replacement therapy should be given according to clinical and laboratory features. PMID:20147343

Ahmad, Firdos; Kannan, Meganathan; Kishor, Kamal; Saxena, Renu

2010-02-10

379

The von Hippel Lindau Tumor Suppressor Limits Longevity  

PubMed Central

Many genes are responsible for the modulation of lifespan in model organisms. In addition to regulating adaptive biologic responses that control stress signaling and longevity, some of these genes participate in tumor formation. The mechanisms that determine longevity and link regulation of lifespan with tumorigenesis are poorly understood. Here, we show that the tumor suppressor von Hippel-Lindau (VHL), which has widely known roles in renal carcinogenesis and the formation of kidney cysts, controls longevity in Caenorhabditis elegans. Loss of vhl-1 significantly increased lifespan and resulted in accelerated basal signaling of the p38 mitogen-activated protein kinase PMK-3. Furthermore, the VHL-1 effect on the regulation of lifespan was independent of the insulin/IGF-1–like signaling pathway, suggesting a mechanism for stress resistance that controls both lifespan and tumorigenesis. These findings define VHL-1 as a player in longevity signaling and connect aging, regulation of lifespan, and stress responses with formation of renal cell carcinomas.

Muller, Roman-Ulrich; Fabretti, Francesca; Zank, Sibylle; Burst, Volker; Schermer, Bernhard

2009-01-01

380

Central nervous system lesions in von Hippel-Lindau syndrome.  

PubMed Central

CNS manifestations were studied in 97 gene carriers of von Hippel-Lindau syndrome (HLS). Haemangioblastomas of the CNS were found in 43 patients (44%), 23 females and 20 males. The mean age at diagnosis was 39 years (12-73 years). A total of 93 haemangioblastomas were detected of which 74% were intracranial and 26% were located in the spinal cord; 75% were predominantly cystic and 25% presented as solid lesions. Multiple lesions were found in 42% of HLS-associated haemangioblastomas, but in none of 51 patients with CNS haemangioblastoma without HLS. Haemangioblastoma was the cause of death in 82% of patients with HLS. Although microsurgery has considerably improved post-operative results, multifocal tumour development and recurrence remain a serious problem in the clinical management of HLS gene carriers. Images

Neumann, H P; Eggert, H R; Scheremet, R; Schumacher, M; Mohadjer, M; Wakhloo, A K; Volk, B; Hettmannsperger, U; Riegler, P; Schollmeyer, P

1992-01-01

381

Central nervous system lesions in von Hippel-Lindau syndrome.  

PubMed

CNS manifestations were studied in 97 gene carriers of von Hippel-Lindau syndrome (HLS). Haemangioblastomas of the CNS were found in 43 patients (44%), 23 females and 20 males. The mean age at diagnosis was 39 years (12-73 years). A total of 93 haemangioblastomas were detected of which 74% were intracranial and 26% were located in the spinal cord; 75% were predominantly cystic and 25% presented as solid lesions. Multiple lesions were found in 42% of HLS-associated haemangioblastomas, but in none of 51 patients with CNS haemangioblastoma without HLS. Haemangioblastoma was the cause of death in 82% of patients with HLS. Although microsurgery has considerably improved post-operative results, multifocal tumour development and recurrence remain a serious problem in the clinical management of HLS gene carriers. PMID:1431953

Neumann, H P; Eggert, H R; Scheremet, R; Schumacher, M; Mohadjer, M; Wakhloo, A K; Volk, B; Hettmannsperger, U; Riegler, P; Schollmeyer, P

1992-10-01

382

Binding of von Willebrand factor to the small proteoglycan decorin.  

PubMed

The small proteoglycan decorin plays an important role in the organisation of the extracellular matrix by binding to several components, including collagen and fibronectin. In this work, we report the dose-dependent and saturable interaction of decorin with the adhesive glycoprotein, von Willebrand factor (VWF). This interaction was mediated by the glycosaminoglycan side chain of decorin and was critically regulated by the degree of sulfation, but not by the amount of iduronic acid. Both chondroitin sulfate and dermatan sulfate, in addition to heparin, were found to bind VWF equally well. Although soluble decorin prevented VWF binding to heparin, purified VWF-A1 domain failed to interact with the proteoglycan. These results identify VWF as a new partner for the small proteoglycan, decorin, in the structural organisation of the extracellular matrix. PMID:15358546

Guidetti, Gianni F; Bartolini, Barbara; Bernardi, Bruno; Tira, Maria E; Berndt, Michael C; Balduini, Cesare; Torti, Mauro

2004-09-10

383

Antigenic Peptides Capable of Inducing Specific Antibodies for Detection of the Major Alterations Found in Type 2B Von Willebrand Disease.  

PubMed

Von Willebrand disease (VWD) is an inherited hemorrhagic disorder promoted by either quantitative or qualitative defects of the von Willebrand factor (VWF). The disease represents the most common human coagulopathy afflicting 1.3% of the population. Qualitative defects are subdivided into four subtypes and classified according to the molecular dysfunction of the VWF. The differential diagnosis of the VWD is a difficult task, relying on a panel of tests aimed to assess the plasma levels and function of the VWF. Here, we propose biochemical approaches for the identification of structural variants of the VWF. A bioinformatic analysis was conducted to design seven peptides among which three were representatives of specific amino acid sequences belonging to normal VWF and four encompassed sequences found in the most common VWD subtype 2B. These peptides were used to immunize mice, after which, peptide-specific immunoglobulins were purified. This resulted in four Ig preparations capable of detecting alterations in the subtype 2B VWD plus additional three antibody fractions targeting the normal VWF. The panel of antibodies could serve many applications among them (1) assessment of VWF: antigen interaction, (2) VWF multimer analysis, and (3) production of monoclonal antibodies against VWF for therapeutic purposes as in thrombotic thrombocytopenic purpura. PMID:23970904

Paro, Marina de Oliveira; Ferreira, Cyntia Silva; Vieira, Fernanda Silva; de Santana, Marcos Aurélio; Castro-Borges, William; Namen-Lopes, Maria Sueli Silva; Leclercq, Sophie Yvette; Velloso-Rodrigues, Cibele; Guerra de Andrade, Milton Hércules

2013-07-18

384

Antigenic Peptides Capable of Inducing Specific Antibodies for Detection of the Major Alterations Found in Type 2B Von Willebrand Disease  

PubMed Central

Von Willebrand disease (VWD) is an inherited hemorrhagic disorder promoted by either quantitative or qualitative defects of the von Willebrand factor (VWF). The disease represents the most common human coagulopathy afflicting 1.3% of the population. Qualitative defects are subdivided into four subtypes and classified according to the molecular dysfunction of the VWF. The differential diagnosis of the VWD is a difficult task, relying on a panel of tests aimed to assess the plasma levels and function of the VWF. Here, we propose biochemical approaches for the identification of structural variants of the VWF. A bioinformatic analysis was conducted to design seven peptides among which three were representatives of specific amino acid sequences belonging to normal VWF and four encompassed sequences found in the most common VWD subtype 2B. These peptides were used to immunize mice, after which, peptide-specific immunoglobulins were purified. This resulted in four Ig preparations capable of detecting alterations in the subtype 2B VWD plus additional three antibody fractions targeting the normal VWF. The panel of antibodies could serve many applications among them (1) assessment of VWF: antigen interaction, (2) VWF multimer analysis, and (3) production of monoclonal antibodies against VWF for therapeutic purposes as in thrombotic thrombocytopenic purpura.

Paro, Marina de Oliveira; Ferreira, Cyntia Silva; Vieira, Fernanda Silva; de Santana, Marcos Aurelio; Namen-Lopes, Maria Sueli Silva; Leclercq, Sophie Yvette; Velloso-Rodrigues, Cibele; Guerra de Andrade, Milton Hercules

2013-01-01

385

Enzymes that hydrolyze adenine nucleotides in platelets and polymorphisms in the alpha2 gene of integrin alpha2beta1 in patients with von Willebrand disease.  

PubMed

Von Willebrand disease (VWD) is one of the most common inherited bleeding diseases caused by a qualitative or quantitative deficiency of the von Willebrand factor (FvW). FvW is a multimeric glycoprotein synthesized by megakaryocytes and endothelial cells and it is present in the subendothelial matrix, blood plasma, platelets, and endothelium. This glycoprotein plays an important role in thrombus formation by initiating platelet adhesion to sites of injury as well as platelet aggregation. The aim of this study was to evaluate the activities of enzymes that hydrolyze adenine nucleotides in platelets, ristocetin-induced platelet aggregation (RIPA), and polymorphisms of the alpha2 gene of alpha2beta1 integrin from VWD patients. Platelet nucleoside triphosphate diphosphohydrolase (NTPDase), 5'-nucleotidase, and ecto-nucleotide pyrophosphatase/phosphodiesterase (E-NPP) activities were verified in 14 VWD patients. For RIPA determination, a final concentration of 1.25 mg/ml of ristocetin was used. Polymorphisms of the alpha2 gene were analyzed through PCR. Platelet NTPDase and E-NPP were decreased in VWD patients. 5'-Nucleotidase activity was not statistically significant between controls and VWD patients. RIPA was significantly reduced, with an allelic frequency of 78.57% for 807C in VWD patients. Our results indicated reduced platelet NTPDase and E-NPP activities which might be related to the low platelet adhesiveness. The prevalence of the 807C allele might account for the variability in bleeding in VWD. PMID:20336352

Santos, Karen Freitas; Battisti, Vanessa; Corrêa, Maísa de Carvalho; Mann, Thaís Rapachi; Pereira, Renata da Silva; Araújo, Maria do Carmo; Brülê, Alice Odete; Schetinger, Maria Rosa Chitolina; Morsch, Vera Maria

2010-03-25

386

[Reference relationships between human and animal in Hildegard von Bingen].  

PubMed

In "De animalibus", the 7th book in the "Liber simplicis medicinae", Hildegard von Bingen describes the characteristics of four-footed land animals. Some of these have a special relationship with humans in that they embody moral qualities. An explanation for this is already given in the preface, which states that human intelligence recognizes these qualities, declaring that "You are this or that sort of creature". Since the relationship that animals have with nature shares a degree of similarity with that of man's, they can be regarded as symbolic representatives for particular human traits and characteristics. The article at hand presents Hildegard von Bingen's descriptions of the monkey, the lion, the bear, the rabbit, the dog, the cat, the wolf, the lynx, and the donkey. While the monkey just mimics man's behaviour and is imperfect in both settings, the lion embodies will power. The bear on the other hand stands for unbridled sexual desire, while in the rabbit the gentleness of a sheep is united with the bounce of a deer. The lynx is regarded as hedonistic, the donkey as stupid, and the wolf as surrounded by dangerous sylphs. In Hildegard's depictions, exotic and native animal species display rather extraordinary behavioural traits, and the medieval Christian world view of the author conveys unexpected relationships between humans and animals. In addition to empirical observation and experience, Hildegard also relies on folkloristic beliefs and magical practices related to explanatory models of her time. She allows largely unknown sources into her animal lore but never strays from her ultimate goal of having it serve to instruct people. In doing so, Hildegard removed herself far from the common tradition of medieval animal portraits. PMID:23155757

Riethe, Peter

2012-01-01

387

John von Neumann and Klaus Fuchs: an Unlikely Collaboration  

NASA Astrophysics Data System (ADS)

I discuss the origin of the idea of making a fusion (hydrogen) bomb and the physics involved in it, and then turn to the design proposed for one by the unlikely collaborators John von Neumann and Klaus Fuchs in a patent application they filed at Los Alamos in May 1946, which Fuchs passed on to the Russians in March 1948, and which with substantial modifications was tested on the island of Eberiru on the Eniwetok atoll in the South Pacific on May 8, 1951. This test showed that the fusion of deuterium and tritium nuclei could be ignited, but that the ignition would not propagate because the heat produced was rapidly radiated away. Meanwhile, Stanislaw Ulam and C.J. Everett had shown that Edward Teller’s Classical Super could not work, and at the end of December 1950, Ulam had conceived the idea of super compression, using the energy of a fission bomb to compress the fusion fuel to such a high density that it would be opaque to the radiation produced. Once Teller understood this, he invented a greatly improved, new method of compression using radiation, which then became the heart of the Ulam-Teller bomb design, which was tested, also in the South Pacific, on November 1, 1952. The Russians have freely acknowledged that Fuchs gave them the fission bomb, but they have insisted that no one gave them the fusion bomb, which grew out of design involving a fission bomb surrounded by alternating layers of fusion and fission fuels, and which they tested on November 22, 1955. Part of the irony of this story is that neither the American nor the Russian hydrogen-bomb programs made any use of the brilliant design that von Neumann and Fuchs had conceived as early as 1946, which could have changed the entire course of development of both programs.

Bernstein, Jeremy

2010-03-01

388

Fehler begehen - Mathematik verstehen Über die Bedeutung von Fehlern für das Verstehen  

NASA Astrophysics Data System (ADS)

Auch wenn eine historisch oder systematisch umfassende Darstellung zur Fehlerthematik bislang nicht vorliegt, ist die Idee, einer Fehleranalyse unter der Leitfrage, welche Fehler von Schülerinnen und Schülern aufgrund welcher epistemologischen Überzeugungen begangen werden, zentralen Raum für die Betrachtung von Verstehensprozessen einzuräumen, nicht neu. So ist es geradezu ein Charakteristikum einer modernen konstruktivistischen Didaktik, die eigenen Fehler von Lernenden als ihre individuellen Lerngelegenheiten zu begreifen, die einen wichtigen Motor für den subjektiven Lernfortschritt bilden. Diese Sichtweise wurzelt aus psychologischer Perspektive in Analysen in der Tradition Piagets, der in Abkehr von einer quantitativen, psychometrischen Beschreibung kognitiver Prozesse, wie sie sich zum Beispiel in Intelligenztheorien nach Binet findet, qualitativ zu beschreiben versuchte, in welcher Weise Kinder und Jugendliche denken und urteilen. Doch auch schon in der klassischen Philosophie sind entsprechende Ansätze zu finden. Prominente Beispiele hierfür sind die Idolenlehre Bacons und die Ideenlehre Platons.

Käser, Udo

389

Susceptibility to Atherosclerosis in Aortas and Coronary Arteries of Swine with von Willebrand's Disease.  

National Technical Information Service (NTIS)

The development of coronary and aortic atherosclerosis was determined after balloon catheter injury of coronary arteries and administration of an atherogenic diet in normal pigs and pigs that were homozygous and heterozygous for von Willebrand's disease. ...

T. R. Griggs R. L. Reddick D. Sultzer K. M. Brinkhous

1980-01-01

390

Successful percutaneous transluminal coronary angioplasty for acute myocardial infarction in von Willebrand's disease.  

PubMed

An elderly woman with mild von Willebrand's disease presented with acute myocardial infarction. Percutaneous transluminal coronary angioplasty, to mechanically disrupt the thrombus without anticoagulation, was successfully undertaken. Haemostatic cover was also avoided. PMID:12410656

James, P R; de Belder, A J; Kenny, M W

2002-11-01

391

Edelgase als Tracer für Wechselwirkungen von Krusten- und Mantelfluiden mit diamantführenden Gesteinen des östlichen Baltischen Schildes  

NASA Astrophysics Data System (ADS)

In der vorliegenden Arbeit werden anhand der Edelgaszusammensetzung von Kimberliten und Lamproiten sowie ihrer gesteinsbildenden Minerale die Wechselwirkungen dieser Gesteine mit Fluiden diskutiert. Die untersuchten Proben stammen vom östlichen Baltischen Schild, vom Kola-Kraton (Poria Guba und Kandalaksha) und vom karelischen Kraton (Kostamuksha). Edelgasanalysen nach thermischer oder mechanischer Gasextraktion von 23 Gesamtgesteinsproben und 15 Mineralseparaten ergeben folgendes Bild: Helium- und Neon-Isotopendaten der Fluideinschlüsse von Lamproiten aus Kostamuksha lassen auf den Einfluss einer fluiden Phase krustaler Herkunft schliessen. Diese Wechselwirkungen fanden wahrscheinlich schon während des Magmenaufstiegs statt, denn spätere Einflüsse krustaler Fluide auf die Lamproite und ihr Nebengestein (Quarzit) sind gering, wie anhand der C/36Ar-Zusammensetzung gezeigt wird. Auch sind die mit verschiedenen Datierungsmethoden (Rb-Sr, Sm-Nd, K-Ar) an Mineralseparaten und teilweise an Gesamtgestein ermittelten Alter konsistent und machen eine metamorphe Überprägung unwahrscheinlich. Aufgrund der Verteilung der primordialen Edelgasisotope zwischen Fluideinschlüssen und Gesteinsmatrix ist ein langsamer Magmenaufstieg anzunehmen, was die Möglichkeit der Kontamination mit einem krustalen Fluid während des Magmenaufstiegs erhöht. Die Gasextraktion aus Mineralseparaten erfolgte thermisch, wodurch eine Freisetzung der Gase ausschließlich aus Fluideinschlüssen nicht möglich ist. Hierbei zeigen Amphibol und Klinopyroxen, separiert aus Kostamuksha-Lamproiten, in ihrer Neon-Isotopenzusammensetzung im Vergleich zur krustalen Zusammensetzung (Kennedy et al., 1990) ein leicht erhöhtes Verhältnis von 20Ne/22Ne, was ein Hinweis auf Mantel-Neon sein könnte. Kalifeldspäte, Quarz und Karbonate enthalten dagegen nur Neon krustaler Zusammensetzung. Phlogopite haben sehr kleine Verhältnisse von 20Ne/22Ne und 21Ne/22Ne, zurückzuführen auf in-situ-Produktion von 22Ne in Folge von U- und Th-Zerfallsprozessen. Wie unterschiedliche thermische Entgasungsmuster für 40Ar und 36Ar zeigen, ist 36Ar in Fluideinschlüssen konzentriert. Das 40Ar/36Ar-Isotopenverhältnis der Fluideinschlüsse von Lamproiten aus Kostamuksha ist antikorreliert mit der durch thermische Extraktion bestimmten Gesamtmenge an 36Ar. Argon aus Fluideinschlüssen setzt sich daher aus zwei Komponenten zusammen: Einer Komponente mit atmosphärischer Argon-Isotopenzusammensetzung und einer krustalen Komponente mit einem Isotopenverhältnis 40Ar/36Ar > 6000. Diffusion von radiogenem 40Ar aus der Kristallmatrix in die Fluideinschlüsse spielt keine wesentliche Rolle. Kimberlite aus Poria Guba und Kandalaksha zeigen anhand der Helium- und z. T. auch der Neon-Isotopenzusammensetzung eine Mantelkomponente in den Fluideinschlüssen an. Bei einem angenommenen 20Ne/22Ne-Isotopenverhältnis von 12,5 in der Mantelquelle ergibt sich ein 21Ne/22Ne-Isotopenverhältnis von 0,073 ± 0,011 sowie ein 3He/4He-Isotopenverhältnis, welches im Vergleich zum subkontinentalem Mantel (Dunai und Baur, 1995) stärker radiogen geprägt ist. Solche Isotopensignaturen sind mit höheren Konzentrationen an Uran und Thorium in der Mantelquelle der Kimberlite zu erklären. Rb-Sr- und Sm-Nd-Altersbestimmungen erfolgten von russischer Seite (Belyatskii et al., 1997; Nikitina et al., 1999) und ergeben ein Alter von 1,23 Ga für den Lamproitvulkanismus in Kostamuksha. Eigene K-Ar-Datierungen an Phlogopiten und Kalifeldspäten stimmen mit einem Alter von 1193 ± 20 Ma fast mit den Rb-Sr- und Sm-Nd-Altern überein. Die K-Ar-Datierung an einem Phlogopit aus Poria Guba, separiert aus dem Kimberlit PGK 12a, ergibt ein Alter von 396 Ma, ebenfalls in guter Übereinstimmung mit Rb-Sr-und Sm-Nd-Altern (ca. 400 Ma, Lokhov, pers. Mitteilung). K-Ar-Altersbestimmungen an Gesamtgestein aus Poria Guba erbrachten kein schlüssiges Alter. Die Rb-Sr- und Sm-Nd-Alter des Lamproitmagmatismus in Poria Guba betragen 1,72 Ga (Nikitina et al., 1999). Vergleiche von gemessenen mit berechneten Edelgaskonzentrationen aus in

Wiersberg, Thomas

2001-11-01

392

Quantitative versus qualitative tourism research  

Microsoft Academic Search

In order to examine the importance of “quantitative” vs. “qualitative” tourism research, similar developments in anthropology arc examined. In addition, the impact of such thought upon marketing is discussed. The tradeoffs of choosing “qualitative” or “scientific” techniques are overtly considered, “science” and “art” in research are operationally defined, and the strength of each method is juxtaposed and justified. Such an

Alf H. Walle

1997-01-01

393

Quantitative analysis for ball lightning  

Microsoft Academic Search

Ball lightning is considered as a spherical standing wave of electromagnetic radiation trapped in a plasma shell. The shell is expelled out from an air-filled cavity by the ponderomotive force. The trapped radiation energy generates plasmas continuously through ohmic heating to prevent the shell from diffusing away. This consideration allows a quantitative analysis for the dimension, temperature, energy and life

Xue-Heng Zheng

1990-01-01

394

Recycling oceanic crust: Quantitative constraints  

Microsoft Academic Search

Recycled ancient oceanic crust with variable amounts of aging, or inclusion of sediments of differing types and origins has often been invoked as a source for present-day ocean island basalts (OIB), but the current evidence remains largely qualitative. Previous quantitative modeling has shown that much has to be learned in order to better understand the implications of crustal recycling on

Andreas Stracke; Michael Bizimis; Vincent J. M. Salters

2003-01-01

395

Recent developments in quantitative proteomics  

Microsoft Academic Search

Proteomics is the study of proteins on a large scale, encompassing the many interests scientists and physicians have in their expression and physical properties. Proteomics continues to be a rapidly expanding field, with a wealth of reports regularly appearing on technology enhancements and scientific studies using these new tools. This review focuses primarily on the quantitative aspect of protein expression

Christopher H. Becker; Marshall Bern

2011-01-01

396

Reproducibility of quantitative coronary analysis  

Microsoft Academic Search

Because of limited storage capacity for digital images, angiographic laboratories without cinefilm are dependent on locally performed quantitative coronary angiography (QCA) in clinical studies. In the present study the intra-and interobserver variability, as well as variability between different laboratories and variability due to frame selection was analyzed. A total of 20 coronary lesions were studied in two different digital laboratories

Per A. Sirnes; Yngvar Myreng; Per Mølstad; Svein Golf

1996-01-01

397

A Quantitative Infrared Spectroscopy Experiment.  

ERIC Educational Resources Information Center

Although infrared spectroscopy is used primarily for qualitative identifications, it is possible to use it as a quantitative tool as well. The use of a standard curve to determine percent methanol in a 2,2,2-trifluoroethanol sample is described. Background information, experimental procedures, and results obtained are provided. (JN)

Krahling, Mark D.; Eliason, Robert

1985-01-01

398

Validity in Quantitative Content Analysis  

ERIC Educational Resources Information Center

Over the past 15 years, educational technologists have been dabbling with a research technique known as quantitative content analysis (QCA). Although it is characterized as a systematic and objective procedure for describing communication, readers find insufficient evidence of either quality in published reports. In this paper, it is argued that…

Rourke, Liam; Anderson, Terry

2004-01-01

399

Chapter 8 Quantitation of Protein  

Microsoft Academic Search

The measurement of protein concentration in an aqueous sample is an important assay in biochemistry research and development labs for applications ranging from enzymatic studies to providing data for biopharmaceutical lot release. Spectrophotometric protein quantitation assays are methods that use UV and visible spectroscopy to rapidly determine the concentration of protein, relative to a standard, or using an assigned extinction

James E. Noble; Marc J. A. Bailey

2009-01-01

400

Quantitative Literacy for Social Justice  

ERIC Educational Resources Information Center

|In this article, we argue that many adults lack the "numeracy" needed to function in a maximally effective manner in their vocational, civic, and personal lives. We believe schools need to foster skills in quantitative literacy (QL), an inclination and ability to make reasoned decisions using general world knowledge and fundamental mathematics in…

Wiest, Lynda R.; Higgins, Heidi J.; Frost, Janet Hart

2007-01-01

401

Quantitative Approach to Camera Fixation.  

National Technical Information Service (NTIS)

The paper deals with quantitative aspects of camera fixation for a static scene. In general, when the camera undergoes translation and rotation, there is an infinite number of points that produce equal optical flow for any instantaneous point in time. Usi...

D. Raviv

1990-01-01

402

Quantitative Models in Marketing Research  

Microsoft Academic Search

Advances in data collection and data storage techniques have enabled marketing researchers to study the individual characteristics of a large range of transactions and purchases, in particular the effects of household-specific characteristics. This 2001 book presents important and practically relevant quantitative models for marketing research. Each model is presented in detail with a self-contained discussion, which includes: a demonstration of

Philip Hans Franses; Richard Paap

2001-01-01

403

Generalized Quantitative Randomized Response Model  

Microsoft Academic Search

Summary In this study we proposed a generalized extension of Ryu et al. (2005) randomized response model (RRM) to estimate the mean of a sensitive quantitative variable. It has been shown that the proposed estimator has advantages over the estimators of Ryu et al. (2005) in terms of efficiency as well as the privacy protection. We also studied the performance

Zawar Hussain; Javid Shabbir

404

Versuche zur Gewinnung von katalytischen Antikörpern zur Hydrolyse von Arylcarbamaten und Arylharnstoffen. (English Title: Attempts to produce catalytic antibodies for hydrolysis of arylcarbamates and arylureas)  

NASA Astrophysics Data System (ADS)

Im Rahmen dieser Arbeit gelang es, katalytische Antikörper zur Hydrolyse von Benzylphenylcarbamaten sowie zahlreiche monoklonale Antikörper gegen Haptene herzustellen. Es wurden verschiedene Hapten-Protein-Konjugate unter Verwendung unterschiedlicher Kopplungsmethoden hergestellt und charakterisiert. Zur Generierung der hydrolytisch aktiven Antikörper wurden Inzuchtmäuse mit KLH-Konjugaten von 4 Übergangszustandsanaloga (ÜZA) immunisiert. Mit Hilfe der Hybridomtechnik wurden verschiedene monoklonale Antikörper gegen diese ÜZA gewonnen. Dabei wurden sowohl verschiedene Immunisierungsschemata als auch verschiedene Inzuchtmausstämme und Fusionstechniken verwendet. Insgesamt wurden 32 monoklonale Antikörper gegen die verwendeten ÜZA selektiert. Diese Antikörper wurden in groen Mengen hergestellt und gereinigt. Zum Nachweis der Antikörper-vermittelten Katalyse wurden verschiedene Methoden entwickelt und eingesetzt, darunter immunologische Nachweismethoden mit Anti-Substrat- und Anti-Produkt-Antikörpern und eine photometrische Methode mit Dimethylaminozimtaldehyd. Der Nachweis der hydrolytischen Aktivität gelang mit Hilfe eines Enzymsensors, basierend auf immobilisierter Tyrosinase. Die Antikörper N1-BC1-D11, N1-FA7-C4, N1-FA7-D12 und R3-LG2-F9 hydrolysierten die Benzylphenylcarbamate POCc18, POCc19 und Substanz 27. Der Nachweis der hydrolytischen Aktivität dieser Antikörper gelang auch mit Hilfe der HPLC. Der katalytische Antikörper N1-BC1-D11 wurde kinetisch und thermodynamisch untersucht. Es wurde eine Michaelis-Menten-Kinetik mit Km von 210 µM, vmax von 3 mM/min und kcat von 222 min-1 beobachtet. Diese Werte korrelieren mit den Werten der wenigen bekannten Diphenylcarbamat-spaltenden Abzyme. Die Beschleunigungsrate des Antikörpers N1-BC1-D11 betrug 10. Das ÜZA Hei3 hemmte die hydrolytische Aktivität. Dies beweist, dass die Hydrolyse in der Antigenbindungsstelle stattfindet. Weiter wurde zwischen der Antikörperkonzentration und der Umsatzgeschwindigkeit eine lineare Abhängigkeit festgestellt. Die thermodynamische Gleichtgewichtsdissoziationskonstante KD des Abzyms von 2,6 nM zeugt von einer sehr guten Affinität zum ÜZA. Hydrolytisch aktiv waren nur Antikörper, die gegen das Übergangszustandsanalogon Hei3 hergestellt worden waren. Es wird vermutet, dass die Hydrolyse der Benzylphenylcarbamate über einen Additions-Eliminierungsmechanismus unter Ausbildung eines tetraedrischen Übergangszustandes verläuft, dessen analoge Verbindung Hei3 ist. Im Rahmen der Generierung von Nachweisantikörpern zur Detektion der Substratabnahme bei der Hydrolyse wurden Anti-Diuron-Antikörper hergestellt. Einer der Antikörper (B91-CG5) ist spezifisch für das Herbizid Diuron und hat einen IC50-Wert von 0,19 µg/l und eine untere Nachweisgrenze von 0,04 µg/l. Ein anderer Antikörper (B91-KF5) reagiert kreuz mit einer Palette ähnlicher Herbizide. Mit diesen Antikörpern wurde ein empfindlicher Labortest, der ein Monitoring von Diuron auf Grundlage des durch die Trinkwasserverordnung festgeschriebenen Wertes für Pflanzenschutzmittel von 0,1 µg/l erlaubt, aufgebaut. Der Effekt der Anti-Diuron-Antikörper auf die Diuron-inhibierte Photosynthese wurde in vitro und in vivo untersucht. Es wurde nachgewiesen, dass sowohl in isolierten Thylakoiden, als auch in intakten Algen eine Vorinkubation der Anti-Diuron-Antikörper mit Diuron zur Inaktivierung seiner Photosynthese-hemmenden Wirkung führt. Wurde der Elektronentransport in den isolierten Thylakoiden oder in Algen durch Diuron unterbrochen, so führte die Zugabe der Anti-Diuron-Antikörper zur Reaktivierung der Elektronenübertragung. Attempts to produce catalytic antibodies for hydrolysis of arylcarbamates and arylureas: The aim of the investigations was to produce antibodies which are able to cleave herbicides resistant to naturally occuring enzymes. Structurally similar carbamate and urea derivatives were chosen for the experiments. Phosphonate derivatives were synthesized that mimick possible transition state analogues in structure and charge. Mice were immunized

Werner, Deljana

2002-05-01

405

Über das Verhalten der Niere nach Injektion größerer Mengen von Casein und substituierten Caseinen  

Microsoft Academic Search

Zusammenfassung  Es wurden die funktionellen und morphologischen Reaktionen der Nieren von Hunden, Kaninchen und Ratten auf Infusionen von\\u000a Lsungen verschieden dargestellter und substituierter Caseine untersucht. Funktionelle Vernderungen konnten nur beim formylsubstituierten\\u000a Casein beobachtet werden. Die beobachteten morphologischen Vernderungen wurden in ihrem zeitlichen Ablauf verfolgt und kurvenmig\\u000a dargestellt. Die einzelnen Prparate unterscheiden sich dabei deutlich. Unsere Befunde sprechen fr eine Fhigkeit der

M. Frimmer; K. Lang; Th. Peters

1950-01-01

406

The Literary Source of the Minnegrotte in Gottfried von Strassburg’s Tristan  

Microsoft Academic Search

This article traces the literary source of the minnegrotte (“Cave of Love”) in Gottfried von Strassburg’s Tristan to Heinrich von Veldeke’s Eneit. The floor plan and interior design of the minnegrotte correlate with Heinrich’s description of two tombs that commemorate the fallen warriors of Pallas, son of Evander, who fights\\u000a on the side of Aeneas, and Camilla, the woman warrior

Dominique Battles

2009-01-01

407

Quantum phase transition and von Neumann entropy of quasiperiodic Hubbard chains  

NASA Astrophysics Data System (ADS)

The half-filled Hubbard chains with the Fibonacci and Harper modulating site potentials are studied in a self-consistent mean-field approximation. A new order parameter is introduced to describe a charge density order. We also calculate the von Neumann entropy of the ground state. The results show that the von Neumann entropy can identify a CDW/SDW (charge density wave/spin density wave) transition for quasiperiodic models.

Zhu, Xuan; Tong, Pei-Qing

2008-05-01

408

Factor VIII-Mediated Global Hemostasis in the Absence of von Willebrand Factor  

Microsoft Academic Search

Although the efficacy of recombinant factor VIII (rFVIII) in the treatment of type 3 von Willebrand disease (VWD) has been\\u000a reported, the mechanisms by which FVIII concentrates devoid of von Willebrand factor (VWF) induce improvements in hemostasis\\u000a are poorly understood. To address the role of FVIII or intrinsic coagulation in the absence of VWF, we performed a hemostatic\\u000a analysis. Blood

Masahiro Takeyama; Shogo Kasuda; Yoshihiko Sakurai; Midori Shima; Tomohiro Takeda; Shoko Omura; Hiroyuki Naka; Akira Yoshioka

2007-01-01

409

Vergleichende Untersuchungen über die Freilufttrocknung und Solartrocknung von Schnittholz unter mitteleuropäischen Wetterverhältnissen  

Microsoft Academic Search

Zusammenfassung  Zur systematischen Untersuchung der Wirksamkeit der Solartrocknung von Schnittholz unter mitteleuropischen Wetterverhltnissen\\u000a im direkten Vergleich zur Freilufttrocknung wurden die im Vorjahr vorgenommenen Versuche noch ein weiteres Jahr, teilweise\\u000a unter modifizierten einstellbaren Trocknungsbedingungen, fortgesetzt. Die in der Zeit von Mitte Mrz bis Ende Oktober 1979\\u000a durchgefhrten drei Vergleichsversuche besttigten allgemein die im Vorjahr erhaltenen Ergebnisse. Eine Beschleunigung der\\u000a Solartrocknung gegenber der

A. Schneider; L. Wagner

1980-01-01

410

Der Einfluss von Beleuchtungsstärke und Temperatur auf die Tagesperiodische laufaktivität des Mehlkäfers, Tenebrio Molitor , L  

Microsoft Academic Search

1.Der Einfluß verschiedener Beleuchtungsstärken und Temperaturen auf die Aktivitätsperiodik von Tenebrio molitor wurde an vier Meßgrößen untersucht: Spontanfrequenz, Phasenwinkeldifferenz, Aktivitätsmenge, a:?-Verhältnis. Die hierfür notwendige Vorbedingung fortauernder Periodizität und variabler Frequenz unter konstanten Bedingungen (selbsterregte und endogene Rhythmik) ist bei Tenebrio gegeben.2.Die Spontanfrequenz (unter konstanten Bedingungen) sinkt mit zunehmender Beleuchtungsstärke. Im Bereich von 0,01 bis 100 Lux nimmt die Periodenlänge im

Michael Lohmann

1964-01-01

411

Über den Jahresgang einiger Zucker in den Blättern von Hedera helix L  

Microsoft Academic Search

Zusammenfassung 1.In Blättern vonHedera helix wurde papierchromatographisch das Vorkommen von freier Glucose, Galaktose, Fructose, Saccharose, Raffinose und Stachyose festgestellt und der Jahresgang dieser Zucker verfolgt.2.Während des ganzen Jahres herrscht mengenmäßig die Saccharose vor, zeigt jedoch während der kalten Jahreszeit eine deutliche Zunahme mit einem Maximum im Spätwinter. Galaktose, Raffinose und Stachyose treten nur im Winter auf, und ihr Gehalt erreicht

K. Jeremias

1958-01-01

412

A Role for von Hippel-Lindau Protein in Pancreatic Cell Function  

Microsoft Academic Search

OBJECTIVE—The Vhlh gene codes for the von Hippel-Lindau protein (VHL), a tumor suppressor that is a key player in the cellular response to oxygen sensing. In humans, a germline mutation in the VHL gene leads to the von Hippel-Lindau disease, a familial syndrome characterized by benign and malignant tumors of the kidney, central nervous system, and pancreas. RESEARCH DESIGN AND

Sapna Puri; David A. Cano; Matthias Hebrok

2009-01-01

413

Otmar von Verschuer collects fingerprints, still imageSite: DNA Interactive (www.dnai.org)  

NSDL National Science Digital Library

DNAi location: Chronicle>In the Third Reich>applying the solutionIn November 1942, Otmar von Verschuer succeeded Eugen Fischer as Director of the Kaiser Wilhelm Institute of Anthropology, Human Genetics, and Eugenics. von Verschuer had been the Director of the Institute of Hereditary Biology and Race Biology at the University of Frankfurt, where he had become famous for his studies of genetic vs. environmental influences in twins. His assistant at the University of Frankfurt was Josef Mengele.

2008-10-06

414

Otmar von Verschuer examines twin boys, still imageSite: DNA Interactive (www.dnai.org)  

NSDL National Science Digital Library

DNAi location: Chronicle>In the Third Reich>applying the solutionIn November 1942, Otmar von Verschuer succeeded Eugen Fischer as Director of the Kaiser Wilhelm Institute of Anthropology, Human Genetics, and Eugenics. von Verschuer had been the Director of the Institute of Hereditary Biology and Race Biology at the University of Frankfurt, where he had become famous for his studies of genetic vs. environmental influences in twins. His assistant at the University of Frankfurt was Josef Mengele.

2008-10-06

415

A 5-V-only 16Mb flash memory with sector erase mode  

Microsoft Academic Search

A 5-V-only 16-Mb CMOS flash memory with sector erase mode is described. An optimized memory cell with diffusion self-aligned drain structure and channel erase are keys to achieving 5-V-only operation. By adopting this erase method and row decoders to apply negative bias, 512-word sector erase can be realized. The auto chip erase time of 4 s has been achieved by

T. Jinbo; H. Nakata; K. Hashimoto; T. Watanabe; K. Ninomiya; T. Urai; M. Koike; T. Sato; N. Kodama; K. Oyama; T. Okazawa

1992-01-01

416

Clausewitz und die „Überlegenheit der Verteidigung“. Zum Stärkeverhältnis von Offensive und Defensive  

Microsoft Academic Search

Zusammenfassung  Eine der zentralen inhaltlichen Botschaften des preußischen Generals und Kriegsphilosophen Carl von Clausewitz, dargelegt\\u000a in seinem Werk Vom Kriege, lautet: „Die Verteidigung ist an sich die stärkere Form des Kriegführens“. Diese Vorstellung steht im Widerspruch zu den\\u000a Ansichten namhafter Autoritäten verschiedener Epochen, insbesondere auch aus der Zeit des Kriegsphilosophen selbst. Gleichzeitig\\u000a steht die Clausewitzsche Theorie von der größeren Stärke der

Johann Schmid

2010-01-01

417

Changes in von Willebrand factor and fibrinolysis following a post-exercise cool-down  

Microsoft Academic Search

The purpose of this study was to determine the effect of a post-exercise active cool-down on von Willebrand factor and fibrinolysis. Ten subjects performed two maximal oxygen uptake ( V?O 2max) tests followed by a 10-min passive (PC) or an active (AC) cool-down. Blood samples were obtained pre-exercise, post-exercise, post-PC\\/AC, and 1 h post-exercise and analyzed for von Willebrand factor antigen

C. M. Paton; P. R. Nagelkirk; A. M. Coughlin; J. A. Cooper; G. A. Davis; H. Hassouna; J. M. Pivarnik; C. J. Womack

2004-01-01

418

Nutzen einer VDD-Defibrillationselektrode zur Aufzeichnung von atrialen Elektrogrammen bei Vorhofflimmern\\/-flattern  

Microsoft Academic Search

Hintergrund: Die Implementierung von atrialen Signalen in die Detektionsalgorithmen implantierbarer Kardioverter-Defibrillatoren hat in den letzten Jahren zu einer deutlich verbeserten Spezifität hinsichtlich der Identifizierung supraventrikulärer Tachyarrhythmien mit entsprechender Verringerung der Anzahl von Fehlinterventionen geführt. Es hat sich jedoch gezeigt, dass diese Zwei-Kammer-Systeme eine deutlich gesteigerte Komplikationsrate aufweisen. Daher entwickelten wir eine Single-Lead-VDD-Elektrode für die Verwendung mit Zwei-Kammer-ICDs. Patienten und Methode:

Michael Niehaus; Griet Thuermer; Stefan Thamasett; Dietrich Pfeiffer; Kirsten Hoeper; Thomas Korte; Heidi Goerler; Roberto Belke; Jürgen Tebbenjohanns

2001-01-01

419

Auftreten von Vorhofflimmern in Abhängigkeit der atrialen Sondenlage bei Zwei-Kammer-Schrittmachern  

Microsoft Academic Search

Zusammenfassung Bei 20-30% der Patienten mit einem Zwei-Kammer-Schrittmacher-System ist eine Umprogrammierung in einen VVI-Modus erforderlich. Ursache hierfür ist in der Mehrzahl der Fälle das Auftreten von Vorhofflimmern. Ziel dieser Studie war es, den Einfluß des Vorhofsonden-Implantationsortes auf die nachfolgende Entwicklung von Vorhofflimmern zu untersuchen. Methode: Bei 109 Patienten wurde ein Zwei-Kammer-Schrittmacher implantiert. Die Indikation war bei 51 Patienten ein AV-Block,

K. Seidl; A. Drögemüller; B. Hauer; N. Schwick; R. Zahn; J. Senges

1998-01-01

420

Koinzidenz von Sklerodermie und primär biliärer ZirrhoseErgebnisse einer systematischen Studie im dermatologischen Krankengut  

Microsoft Academic Search

Zusammenfassung  \\u000a Es werden erstmals im deutschsprachigen dermatologischen Schrifttum Ergebnisse einer systematischen Untersuchung über den\\u000a Zusammenhang von Sklerodermie, antimitochondrialen Antikörpern (AMA) und primär biliärer Zirrhose (PBC) vorgestellt. Wir haben\\u000a 40 Patienten mit unterschiedlichen Formen der systemischen und zirkumskripten Sklerodermie untersucht. In 5 Fällen (12,5%)\\u000a fanden sich im Serum ausschließlich von weiblichen Patienten mittels indirekter Immunfluoreszenz antimitochondriale Antikörper\\u000a (AMA), die durch ELISA

H.-D. Göring; Martina Panzner; W. Lakotta; A. Ziemer

1998-01-01

421

Dosierung von Botulinumtoxin Typ B bei spasmodischer Dysphonie vom Adduktortyp  

Microsoft Academic Search

Zusammenfassung Spasmodische Dysphonien vom Adduktortyp werden heute bevorzugt mit wiederholten intralaryngealen Injektionen von Botulinumtoxin Typ A behandelt. Abhängig von der kumulativen Dosis entwickeln einige Patienten Antikörper gegen das Toxin, sodass die wiederholte Behandlung unwirksam wird. In diesem Fall ist das Neurotoxin Typ B (NeuroBloc ®) indiziert. Dabei muss der Anwender eine zum Neurotoxin A „äquivalente“ Dosis finden, die für die zervikale Dystonie gegenüber Botox

R. Schönweiler; P. Zwirner

2005-01-01

422

Methoden und Vorteile des Gebrauchs von computerassistiertem, interaktivem 3-D-Design und Multimedia-Lernprogrammen in der Demonstration und Lehre von neuroophthalmologischen Grundlagen der Okulomotorik  

Microsoft Academic Search

\\u000a Zusammenfassung\\u000a Hintergrund  Die Lehre der Neuroophthalmologischen Grundlagen der Okulomotorik ist wegen der Unanschaulichkeit der Materie eine große Herausforderung.\\u000a Um die Lehre dieses schwierigen Faches zu verbessern, wurden unter Verwendung von 3-D-Animationsprogramrnen und Multimedia-Autorenprogrammen\\u000a interaktive 3-D-Lehrprogramme entwickelt und auf ihre Effizienz geprüft.\\u000a \\u000a \\u000a \\u000a Methodik  Anhand von 42 Studenten wurden die erschaffenen Programme mit herkömmlichen Unterrichtsmethoden verglichen. Die Studenten\\u000a wurden in zwei Gruppen aufgeteilt und

C. G. O. Glittenberg

2003-01-01

423

[Prenatal exclusion of von Hippel-Lindau syndrome in a Mexican family carrying a novel VHL gene mutation].  

PubMed

Von Hippel-Lindau syndrome is an autosomal dominant and familial multisystemic syndrome that is caused by the inactivation of the VHL gene and it is characterized by diverse types of high vasculated tumors of benign and malign nature. This paper reports the clinical characteristics and prenatal diagnosis of a woman with von Hippel-Lindau syndrome, who constitutes the first exclusion prenatal case by DNA analysis of the Von Hippel-Lindau syndrome in Latin-American population. PMID:23720934

Chacón-Camacho, Oscar Francisco; Benitez-Granados, Jesús; Zenteno, Juan Carlos

2013-04-01

424

Zur Frage der Transformation von Atem- in BlutalkoholkonzentrationenExperimentelle Untersuchungen mit einem geeichten Atemalkoholtestgerät Alcotest 7110 Evidential MK III  

Microsoft Academic Search

  \\u000a Mit dem Alcotest 7110 Evidential MK III, durch die PTB in Braunschweig zugelassen und geeicht, steht ein hochwertiges Gertesystem\\u000a zur Messung der Alkoholkonzentration in der Ausatemluft zur Verfgung. Der Umrechnungsfaktor von Atem- in Blutalkoholkonzentrationen\\u000a wurde von Schoknecht [17] im Gutachten des Bundesgesundheitsamtes 1992 experimentell als BAK\\/AAK-Quotient mit 2,098 0,11\\u000a bestimmt und auf 2,1 gerundet. Der Mittelwert von 455 zeitgleichen

K. Jachau; U. Schmidt; H. Wittig; W. Römhild; D. Krause

2000-01-01

425

Quantitative tear ferning. Clinical investigations.  

PubMed

The tears of 225 subjects were examined for several disorders of the eye by means of a newly developed method, the quantitative tear ferning test. Of the 225 subjects, 89 were normal controls, 24 were examined before and after cataract extraction, and 112 had some disease of the external part of the eye. Using the quantitative tear ferning test, it was shown that compared to normals, the ferning area was significantly decreased in cases of keratoconjunctivitis sicca, in primary and in secondary Sjögren's syndrome. This was also the case in infectious conjunctivitis and after cataract extraction, possibly due to exudation from the conjunctival vessels. In simple conjunctivitis, however, the ferning area was normal. The ferning method has a sensitivity and a specificity of the same order as the commonly used tests for Sjögren's syndrome (Schirmer I, BUT, rose bengale, lactoferrin). PMID:7976270

Norn, M

1994-06-01

426

Quantitative evaluation of nation stability  

Microsoft Academic Search

This paper quantitatively evaluates nation stability, defined as the state of a country's social and economic system as measured by multiple evaluation indicators, and observes its transitions. Data Envelopment Analysis\\/Malmquist Index (DEA\\/MI) methodology is applied to the panel data for 97 countries for the period 1981–2004, although the DEA application is totally different from the DEA efficiency\\/productivity analysis. This analysis

Takao Tsuneyoshi; Akihiro Hashimoto; Shoko Haneda

427

Quantitative methods in nursing research.  

PubMed

This paper considers some of the general principles that are common to much of quantitative research in nursing. In particular, the role of hypothesis testing is considered, and the use of estimation is emphasized. Confidence intervals are advocated as a means of assessing both statistical and clinical significance. These principles and methods are illustrated using examples taken from the nursing literature. Finally, more complicated situations and the role of design are discussed. PMID:8732530

Abrams, K R; Scragg, A M

1996-05-01

428

Quantitative fractography: A modern perspective  

Microsoft Academic Search

The important aspects of quantitative fractography as a new analytical tool for understanding material fracture are discussed.\\u000a The special considerations that rise in the quantification problems are examined from the purview of stereology. Two major\\u000a experimental techniques for obtaining geometrical information about the fracture surface topography are critically evaluated.\\u000a These methods are based on stereophotogrammetry or vertical sectioning procedures-both of

K. Banerji

1988-01-01

429

Definition and Quantitation in Ecology  

Microsoft Academic Search

AUSTIN1, in commenting on my communication2, has provided an example of the problems which arise in justifying a non-quantitative approach to a subject such as ecology. Austin attaches significance to an imprecision of definition in my examination of the relationships among functional properties of Californian grasslands, and concludes ``more adequate definitions are necessary before McNaughton's suggestions ... can profitably be

S. J. McNaughton

1968-01-01

430

[Acquired deficiency of von Willebrand factor (wWF) associated with intestinal angiodysplasia. An unusual clinical case].  

PubMed

A rare case of acquired von Willebrand's disease associated with intestinal angiodysplasia is described. The case is very interesting because it clinically mimicked an intestinal neoplasm. PMID:10479869

Lioniello, M; Perrotta, A; Reccia, L; Fichera, G; Casolaro, V; Tuccillo, A; Perrotta, S; Federico, R; D'Orazi, B; Veloce, C; Peltrini, A

1999-06-01

431

QUANTITATIVE INVESTIGATIONS OF IDIOTYPIC ANTIBODIES  

PubMed Central

The effect of challenge by antigen on persistence of clones of antibody-producing cells and on the induction of new clones was investigated through quantitative measurements of idiotypic specificities. In each of nine rabbits idiotypic specificities present in the earliest bleedings were completely replaced after a few months; subsequent changes occurred much more slowly. On a quantitative basis the population of molecules used as immunogen always reacted most effectively with the homologous anti-idiotypic antiserum. Little effect of increased antigen dose on the rate of change of idiotype was observed. Even large amounts of antigen administered every 2 wk caused only gradual changes in idiotypic specificities. This was attributed either to more effective capture of antigen by memory cells, as compared to precursor cells, or to the induction of tolerance in those clones that were not expressed. In two of three rabbits on a monthly injection schedule, the idiotypic specificities identified underwent very slow changes over a period as long as 17 months. Changes occurred more rapidly when antigen was administered every 2 wk. In each of four rabbits investigated, all idiotypic specificities identified before a 5 month rest period were still present afterwards, indicating the survival of essentially all clones of antibody-producing cells during that interval. Quantitative inhibition data indicated that some new clones of cells were initiated.

Spring, Susan B.; Schroeder, Kenneth W.; Nisonoff, Alfred

1971-01-01

432

Acquired von Willebrand syndrome: data from an international registry.  

PubMed

The acquired von Willebrand syndrome (AvWS) is a rare bleeding disorder with laboratory findings similar to those of congenital von Willebrand disease (vWD). Despite the numerous cases reported in the literature until 1999 (n = 266), large studies on AvWS are not available. Moreover, diagnosis of AvWS has been difficult and treatment empirical. These considerations prompted us to organize an international registry. A questionnaire, devised to collect specific information on AvWS, was sent to all the members of the International Society on Thrombosis and Haemostasis (ISTH), who were invited to respond if they had diagnosed cases with the AvWS cases. 156 members answered the questionnaire and 54 of them sent information on 211 AvWS cases from 50 centers. Data were compared with those already published in the literature and 25 cases already described or not correctly diagnosed were excluded. The 186 AvWS cases that qualified for the registry were associated with lymphoproliferative (48%) and myeloproliferative disorders (15%), neoplasia (5%), immunological (2%), cardiovascular (21%) and miscellaneous disorders (9%). Ristocetin cofactor activity (vWF:RCo) or collagen binding activity (vWF:CBA) were usually low in AvWS (median values 20 U/dL, range 3-150), while factor VIII coagulant activity was sometimes normal (median 25 U/dL, range 3-191). FVIII/vWF inhibiting activities were present in only a minority of cases (16%). Bleeding episodes in AvWS were mostly of mucocutaneous type (68%) and were managed by DDAVP (32%), FVIII/vWF concentrates (37%), intravenous immunoglobulins (33%), plasmapheresis (19%), corticosteroids (19%) and immunosuppressive or chemotherapic agents (35%). Based upon the data of this international registry, it appears that AvWS is especially frequent in lympho- or myeloproliferative and cardiovascular diseases. Therefore, AvWS should be suspected and searched with the appropriate laboratory tests especially when excessive bleeding occurs in patients with these disorders. On the basis of the information provided by this registry guidelines for diagnosis and management of the AvWS are given. PMID:10959711

Federici, A B; Rand, J H; Bucciarelli, P; Budde, U; van Genderen, P J; Mohri, H; Meyer, D; Rodeghiero, F; Sadler, J E

2000-08-01

433

Storage of Factor VIII Variants with Impaired von Willebrand Factor Binding in Weibel-Palade Bodies in Endothelial Cells  

PubMed Central

Background Point mutations resulting in reduced factor VIII (FVIII) binding to von Willebrand factor (VWF) are an important cause of mild/moderate hemophilia A. Treatment includes desmopressin infusion, which concomitantly increases VWF and FVIII plasma levels, apparently from storage pools containing both proteins. The source of these VWF/FVIII co-storage pools and the mechanism of granule biogenesis are not fully understood. Methodology/Principal Findings We studied intracellular trafficking of FVIII variants implicated in mild/moderate hemophilia A together with VWF in HEK293 cells and primary endothelial cells. The role of VWF binding was addressed using FVIII variants displaying reduced VWF interaction. Binding studies using purified FVIII proteins revealed moderate (Arg2150His, Del2201, Pro2300Ser) to severe (Tyr1680Phe, Ser2119Tyr) VWF binding defects. Expression studies in HEK293 cells and primary endothelial cells revealed that all FVIII variants were present within VWF-containing organelles. Quantitative studies showed that the relative amount of FVIII storage was independent of various mutations. Substantial amounts of FVIII variants are co-stored in VWF-containing storage organelles, presumably by virtue of their ability to interact with VWF at low pH. Conclusions Our data suggest that the potential of FVIII co-storage with VWF is not affected in mild/moderate hemophilia A caused by reduced FVIII/VWF interaction in the circulation. These data support the hypothesis that Weibel-Palade bodies comprise the desmopressin-releasable FVIII storage pool in vivo.

van den Biggelaar, Maartje; Bouwens, Eveline A. M.; Voorberg, Jan; Mertens, Koen

2011-01-01

434

Determination of selenium in human blood serum. Comparison of two atomic-absorption spectrometric procedures  

Microsoft Academic Search

\\u000a Zusammenfassung  Zwei atomabsorptionsspektrometrische Verfahren, eine Direktbestimmung im Graphitrohrofen und eine Naßveraschung mit Salpetersäure,\\u000a gefolgt von einer Messung mit der Hydridtechnik, werden für die Bestimmung von Selen in menschlichem Blutserum verglichen.\\u000a Das Direktverfahren mit Graphitrohrofen ist störfrei, wenn mit einer Zeemaneffekt-Untergrundkompensation, Atomisierung von\\u000a einer L'vov-Plattform, und einer Isoformierungshilfe aus Kupfer und Eisen zur Matrixmodifikation gearbeitet wird. Auch die\\u000a Bestimmung mit der Hydridtechnik

B. Welz; M. Melcher; G. Schlemmer

1983-01-01

435

Seltene Ursache einer hämorrhagischen Diathese  

Microsoft Academic Search

Zusammenfassung  Vor elektiven Operationen ist neben der gezielten Anamnese zur Erfassung einer erhöhten Blutungsneigung die Bestimmung von\\u000a Thrombozyten, Quick-Wert\\/INR und aPTT obligat. Bei pathologischen Werten sind nach Ausschluss häufiger Ursachen (z. B. Leberzirrhose)\\u000a weitere Laboruntersuchungen nötig. So sollten eine Einzelfaktorenanalyse mit Bestimmung des von Willebrand-Faktor-Antigens\\u000a und ggf. weitere Tests zur Abklärung eines von Willebrand-Syndroms sowie Plättchenfunktionstests erfolgen.\\u000a \\u000a Eine hereditäre Dysfibrinogenämie ist eine

J. Radke; M. Teich; M. Meyer; S. Kirschner; J. Neidel; G. Ehninger; G. Siegert; U. Platzbecker

2009-01-01

436

Quantitative Health Risk Assessment for Particulate Matter.  

National Technical Information Service (NTIS)

The EPAs Office of Air Quality Planning and Standards (OAQPS) has developed this quantitative health risk assessment (RA) describing the quantitative assessments of PM-related risks to public health to support the review of the primary PM standards. This ...

2010-01-01

437

[Hermann von Helmholtz and Carl Stumpf on consonance and dissonance].  

PubMed

The article juxtaposes Hermann von Helmholtz's work in the experimental physiology of hearing and Carl Stumpf's tone psychology, focusing on the problem of consonance and dissonance in music. It argues that the experimental set-up plays a major role in the approaches to hearing of both Helmholtz and Stumpf, shaping their redefinition of the musical concepts of consonance and dissonance. Helmholtz, however, explains dissonance as resulting from the beats that are heard when sound waves interfere, while Stumpf explains consonance from the fusion (Verschmelzung) of sounds, noting that two tones, depending on their distance cannot always be recognized as two but are heard as one single tone. Helmholtz's definition of dissonance eventually threatens his own theory of hearing, which is based on the mechanical principle of resonance and considers sound to be composed of sinusoidal waves. Both the physical and the mathematical tools he uses cannot easily be brought into accordance with his experimental findings on beats, which ask for a discrimination of fast changes in intensity. Dissonance thus becomes "unrecomendable" for Helmholtz, because it overstrains the ear. Stumpf's research, in contrast, has its point of departure in the historically given set of intervals and tries to find a principle that would explain this choice. His tests with experimental subjects who have no conscious knowledge of musical harmony and prove incapable to follow or reproduce music reveals to him a difference between the unity and multiplicity of tones. PMID:19048722

Kursell, Julia

2008-06-01

438

Diagnosis and management of von Willebrand disease in The Netherlands.  

PubMed

In the Netherlands, specialized care for patients with a bleeding disorder, including hemophilia, von Willebrand disease (VWD), and allied disorders, is concentrated in 13 Hemophilia Treatment Centers. The Dutch Hemophilia Treaters Society, the Dutch Hemophilia Nurses' Society, and the Netherlands Hemophilia Patients Society collaborate to optimize management of patients with a bleeding disorder. A recently updated consensus guideline of hemophilia and allied bleeding disorders provide guidance on the current optimal diagnostic strategy and treatment of VWD. Genetic testing is not routinely performed in the Netherlands. Desmopressin (DDAVP) is the choice of treatment in VWD patients responsive to DDAVP, as determined by a test infusion. Coagulation factor concentrates are used in nonresponsive individuals, in case of a contraindication for DDAVP, or in type 2B and type 3 VWD. These concentrates are available for all patients in the Netherlands; however, these may only be administered in a Hemophilia Treatment Center or under the care of a Hemophilia Treatment Center. Recently a study on moderate and severe VWD (the Willebrand in Netherlands study) was initiated to obtain more insight on VWD diagnosis, treatment, and the burden of the disease. PMID:22102190

de Wee, Eva M; Leebeek, Frank W G; Eikenboom, Jeroen C J

2011-11-18

439

Oxidationskinetik von Schwefel auf einer Palladium(111)-Oberfläche  

NASA Astrophysics Data System (ADS)

Die Reaktionskinetik für die Oxidation von Schwefel auf einer Pd(111)-Oberfläche wurde mittels massenspektrometrischer Analyse der Desorptionsprodukte und Augerelektronenspektroskopie (AES) für Schwefelbedeckungsgrade bis maximal s = 3/7 untersucht. Neben umfangreichem empirischen Material über die unter stationären äußeren Bedingungen ablaufende S-Oxidation (T = 5201075 K, po2 = 2 . 10-72 . 10-5 mbar) konnte Einblick in den Reaktionsmechanismus gewonnen werden. Dieser läßt sich weder als reiner Langmuir-Hinshelwood- noch als reiner Eley-Rideal-Mechanismus klassifizieren, sondern läuft unter dem Einfluß eines Precursors ab.Translated AbstractOxidationkinetics of Sulfur on a Palladium (111) SurfaceThe reaction kinetics for the oxidation of sulfur adsorbed on a Pd(111) surface was studied by mass-spectrometric analysis of the desorption products and by means of Auger electron spectroscopy up to a sulfur coverage of s = 3/7. Besides receiving numerous data concerning the S-oxidation under stationary conditions (T = 5201075 K, po2 = 2 . 10-72 . 10-5 mbar) insight could be taken into the reaction mechanism. This can't be described as a pure Langmuir-Hinshelwood- or as a pure Eley-Rideal-mechanism, but it is strongly influenced by a precursor state.

Kölzer, J. G.; Wassmuth, H.-W.

440

Dynamo threshold detection in the von Kármán sodium experiment.  

PubMed

Predicting dynamo self-generation in liquid metal experiments has been an ongoing question for many years. In contrast to simple dynamical systems for which reliable techniques have been developed, the ability to predict the dynamo capacity of a flow and the estimate of the corresponding critical value of the magnetic Reynolds number (the control parameter of the instability) has been elusive, partly due to the high level of turbulent fluctuations of flows in such experiments (with kinetic Reynolds numbers in excess of 10(6)). We address these issues here, using the von Kármán sodium experiment and studying its response to an externally applied magnetic field. We first show that a dynamo threshold can be estimated from analysis related to critical slowing down and susceptibility divergence, in configurations for which dynamo action is indeed observed. These approaches are then applied to flow configurations that have failed to self-generate magnetic fields within operational limits, and we quantify the dynamo capacity of these configurations. PMID:23944544

Miralles, Sophie; Bonnefoy, Nicolas; Bourgoin, Mickael; Odier, Philippe; Pinton, Jean-François; Plihon, Nicolas; Verhille, Gautier; Boisson, Jean; Daviaud, François; Dubrulle, Bérengère

2013-07-08

441

Darwin the geologist: Between Lyell and von Buch.  

PubMed

Upon returning from his voyage on the Beagle, Darwin prepared reports of his geological observations. Together, these reveal Darwin's approach to reasoning about geology. Darwin argued that successive terraces prove a very gradual elevation of the coast that lagoon islands show a reciprocal sinking of the oceanic floor. Hence, Darwin reinforced Lyell's uniformitarian, or steady state theory. Unlike lagoon islands, the movement of erratic boulders onto the plains is evidence of forces, which do not now exist. Darwin and Lyell attributed this movement to floating icebergs. However, mountain formation remained difficult for them to explain with reference to contemporary causes. Lyell discovered uplifts in Scandinavia, which resulted from epirogenesis, whereas mountain formation is an orogenesis, which involves both folding and uplift. Darwin was more impressed by uplift than by folds. However, when in Cordillera he saw strata overturned by masses of injected rock, proving successive periods of violence, Darwin took a position, which was closer to the plutonic theories of von Buch and Humboldt than it was to Lyell's uniformitarian views. PMID:20338524

Gohau, Gabriel

2010-02-09

442

von Kármán-Howarth relationship for helical magnetohydrodynamic flows.  

PubMed

We derive an exact equation for homogeneous isotropic magnetohydrodynamic (MHD) turbulent flows with nonzero helicity; this result is of the same nature as the classical von Kármán-Howarth (VKH-HM) formulation for the kinetic energy of turbulent fluids. Helical MHD is relevant to the astrophysical flows such as in the solar corona, or the interstellar medium, and in the dynamo problem. The derivation involves the new writing of the general form of tensors for that case, for either vectors or (pseudo)axial vectors. It is shown that, for general third-order tensors, four generating functions are needed when taking into account the nonmirror invariance of helical fluids, instead of two as in the fully isotropic case. The new equation obtained, denoted by VKH-HM, links the dissipation of magnetic helicity to the third-order correlations involving combinations of the components of the velocity, the magnetic field, and the magnetic potential. Finally, in the long-time and nonresistive limit, this relationship leads to a linear scaling with separation of the third-order tensor, correlating the two normal components of the electromotive force and of the magnetic potential. PMID:14525113

Politano, H; Gomez, T; Pouquet, A

2003-08-29

443

Front End Schaltung zur Online Auswertung von EKG-Signalen  

NASA Astrophysics Data System (ADS)

Ein mobiles EKG-System zur Online Auswertung von EKG-Signalen wird dargestellt. Die Auswertung beruht auf ein energiesparendes Verfahren, das den Vorteil einer zulässigen Unterabtastung des Signals bietet und eine Interaktion zwischen der messenden Elektronik und dem funkgebundenen Auswertungsrechner ermöglicht. Diese Interaktion besteht darin, sowohl die Front End Schaltung im EKG-Sensor als auch den im ATmega8L eingebetteten A/D-Wandler vom Auswertungsrechner zu steuern und den Datenbedarf des Rechners dynamisch an die Erfordernisse des Analyseprogramms anzupassen. Das entwickelte EKG-System liefert erfolgreiche Charakterisierungen erfasster Elektrokardiogramme. A mobile ecg-system for an online analysis of electrocardiogram signals is presented. The analysis is based on an energy-saving procedure, which offers the advantage of an acceptable undersampling of the signal, and which allows an interaction between the measuring electronic and the radio-bound analysis-computer. In this interaction both the front-end circuit in the ecg-sensor and the A/D converter, which is embedded in the ATmega8L, are steered by the analysis computer. The data requirement of the computer is also dynamically adapted to the requirements of the analysis-program. The developed ecg-system supplies successful characterisations of measured electrocardiograms.

Ayari, E.; Tielert, R.

2007-06-01

444

The von Hippel Lindau tumor suppressor limits longevity.  

PubMed

Many genes are responsible for the modulation of lifespan in model organisms. In addition to regulating adaptive biologic responses that control stress signaling and longevity, some of these genes participate in tumor formation. The mechanisms that determine longevity and link regulation of lifespan with tumorigenesis are poorly understood. Here, we show that the tumor suppressor von Hippel-Lindau (VHL), which has widely known roles in renal carcinogenesis and the formation of kidney cysts, controls longevity in Caenorhabditis elegans. Loss of vhl-1 significantly increased lifespan and resulted in accelerated basal signaling of the p38 mitogen-activated protein kinase PMK-3. Furthermore, the VHL-1 effect on the regulation of lifespan was independent of the insulin/IGF-1-like signaling pathway, suggesting a mechanism for stress resistance that controls both lifespan and tumorigenesis. These findings define VHL-1 as a player in longevity signaling and connect aging, regulation of lifespan, and stress responses with formation of renal cell carcinomas. PMID:19797165

Müller, Roman-Ulrich; Fabretti, Francesca; Zank, Sibylle; Burst, Volker; Benzing, Thomas; Schermer, Bernhard

2009-09-24

445

Untersuchungen zum Erlernen von Spektralfarben durch die Honigbiene ( Apis mellifica )  

Microsoft Academic Search

1.Under natural day light conditions (700 Lx) individual bees were offered horizontaly situated spectral lights as food signals marking a two molar sucrose solution. The radiation density of the colours corresponds approximately to that of flowers under a hazy sun (Table 3).2.A method of quantitatively investigating learning of spectral colours in bees is described. After bees were introduced to the

R. Menzel

1967-01-01

446

Determination of bismuth, cadmium and thallium in 33 international standard reference rocks by fractional distillation combined with flameless atomic absorption spectrometry  

Microsoft Academic Search

Die Bestimmung von Wismut, Cadmium und Thallium in Gesteinen kann mit der flammenlosen Atomabsorptions-Spektroskopie nach verdampfungsanalytischer Abtrennung erfolgen. Die Verdampfungsnalyse hat den Vorteil, daß bei geringem Reagentienverbrauch kleine Mengen analysiert werden können. Die Gefahr der Einschleppung von Verunreinigungen wird erheblich vermindert. Die Nachweisgrenze bezogen auf die Probe beträgt für Wismut und Thallium ca. 1 ppb und für Cadmium ca. 0.1

H. Heinrichs

1979-01-01

447

Qualitative vs quantitative modelling: the evolving balance  

Microsoft Academic Search

This paper addresses the issue of what are the wise uses of qualitative mapping and what are the conditions that require formal quantitative modelling within System Dynamics. The background to the evolution of qualitative and quantitative system dynamics will be explored. This analysis will recognises that although the history of feedback thought repeatedly contains the assertion that formal, quantitative models

Eric Wolstenholme

1999-01-01

448

Quantitative basin analysis methods and applications  

Microsoft Academic Search

Quantitative basin analysis has become increasingly important in petroleum exploration. Chapter 1 presents a quantitative basin analysis study from the Georges Bank Basin, East Coast of the USA. By applying a one-dimensional fluid flow\\/compaction model to the well data of the basin, the author obtains a quantitative understanding of the basin's geohistory, geothermal history, and hydrocarbon generation history so that

Jianchang

1990-01-01

449

The NIST quantitative infrared database  

SciTech Connect

With the recent developments in Fourier transform infrared (FTIR) spectrometers it is becoming more feasible to place these instruments in field environments. As a result, there has been enormous increase in the use of FTIR techniques for a variety of qualitative and quantitative chemical measurements. These methods offer the possibility of fully automated real-time quantitation of many analytes; therefore FTIR has great potential as an analytical tool. Recently, the US Environmental Protection Agency (USEPA) has developed protocol methods for emissions monitoring using both extractive and open-path FTIR measurements. Depending upon the analyte, the experimental conditions and the analyte matrix, approximately 100 of the hazardous air pollutants (HAPs) listed in the 1990 USEPA Clean Air Act amendment (CAAA) can be measured. The National Institute of Standards and Technology (NIST) has initiated a program to provide quality-assured infrared absorption coefficient data based on NIST prepared primary gas standards. Currently, absorption coefficient data has been acquired for approximately 20 of the HAPs. For each compound, the absorption coefficient spectrum was calculated using nine transmittance spectra at 0.12 cm{sup {minus}1} resolution and the Beer`s law relationship. The uncertainties in the absorption coefficient data were estimated from the linear regressions of the transmittance data and considerations of other error sources such as the nonlinear detector response. For absorption coefficient values greater than 1 {times} 10{sup {minus}4} {mu}mol/mol{sup {minus}1} m{sup {minus}1} the average relative expanded uncertainty is 2.2%. This quantitative infrared database is currently an ongoing project at NIST. Additional spectra will be added to the database as they are acquired. The current plans include continued data acquisition of the compounds listed in the CAAA, as well as the compounds that contribute to global warming and ozone depletion.

Chu, P.M.; Guenther, F.R.; Rhoderick, G.C.; Lafferty, W.J. [National Inst. of Standards and Technology, Gaithersburg, MD (United States)

1999-01-01

450

Quantitative biology of single neurons  

PubMed Central

The building blocks of complex biological systems are single cells. Fundamental insights gained from single-cell analysis promise to provide the framework for understanding normal biological systems development as well as the limits on systems/cellular ability to respond to disease. The interplay of cells to create functional systems is not well understood. Until recently, the study of single cells has concentrated primarily on morphological and physiological characterization. With the application of new highly sensitive molecular and genomic technologies, the quantitative biochemistry of single cells is now accessible.

Eberwine, James; Lovatt, Ditte; Buckley, Peter; Dueck, Hannah; Francis, Chantal; Kim, Tae Kyung; Lee, Jaehee; Lee, Miler; Miyashiro, Kevin; Morris, Jacqueline; Peritz, Tiina; Schochet, Terri; Spaethling, Jennifer; Sul, Jai-Yoon; Kim, Junhyong

2012-01-01

451

Quantitative Study of Arthropod Ecology  

NSDL National Science Digital Library

This activity allows students who have gained experience in Berlese funnel extraction of microarthropods ("Microarthropod Collection and Examination") and microarthropod identifications ("Microarthropod Variation and Taxonomy") the opportunity to take part in the process that actual scientists go through in their own work. Students begin with online reading and an online literature search to better understand the use of population indices in biological investigations. They follow by writing a brief proposal for their own investigation. This activity melds student skills in microarthropod extraction and classification with independent investigation involving quantitative arthropod ecology study.

452

Recent advances in quantitative neuroproteomics.  

PubMed

The field of proteomics is undergoing rapid development in a number of different areas including improvements in mass spectrometric platforms, peptide identification algorithms and bioinformatics. In particular, new and/or improved approaches have established robust methods that not only allow for in-depth and accurate peptide and protein identification and modification, but also allow for sensitive measurement of relative or absolute quantitation. These methods are beginning to be applied to the area of neuroproteomics, but the central nervous system poses many specific challenges in terms of quantitative proteomics, given the large number of different neuronal cell types that are intermixed and that exhibit distinct patterns of gene and protein expression. This review highlights the recent advances that have been made in quantitative neuroproteomics, with a focus on work published over the last five years that applies emerging methods to normal brain function as well as to various neuropsychiatric disorders including schizophrenia and drug addiction as well as of neurodegenerative diseases including Parkinson's disease and Alzheimer's disease. While older methods such as two-dimensional polyacrylamide electrophoresis continued to be used, a variety of more in-depth MS-based approaches including both label (ICAT, iTRAQ, TMT, SILAC, SILAM), label-free (label-free, MRM, SWATH) and absolute quantification methods, are rapidly being applied to neurobiological investigations of normal and diseased brain tissue as well as of cerebrospinal fluid (CSF). While the biological implications of many of these studies remain to be clearly established, that there is a clear need for standardization of experimental design and data analysis, and that the analysis of protein changes in specific neuronal cell types in the central nervous system remains a serious challenge, it appears that the quality and depth of the more recent quantitative proteomics studies is beginning to shed light on a number of aspects of neuroscience that relates to normal brain function as well as of the changes in protein expression and regulation that occurs in neuropsychiatric and neurodegenerative disorders. PMID:23623823

Craft, George E; Chen, Anshu; Nairn, Angus C

2013-04-25

453

Untersuchungen und Betrachtungen zur Anwendung von Kunststoffen für Lebensmittel XIII. Mitteilung Zum Verhalten von Kunststoffen gegenüber Milch  

Microsoft Academic Search

Summary By means of a method described in full details it was possible to determine quantitatively the fat of milk penetrated into plastics. In addition the amounts of monomer plasticizers were determined, which emigrate from soft-PVC into milk under special experimental conditions. From the results it is concluded that the intensity of these diffusion processes clearly depends on temperature. Convection

Gerhard Wilderett; Karl-Wolfgang Evers; Friedrich Kiermeier

1970-01-01

454

Quantitative genetics in conservation biology.  

PubMed

Most of the major genetic concerns in conservation biology, including inbreeding depression, loss of evolutionary potential, genetic adaptation to captivity and outbreeding depression, involve quantitative genetics. Small population size leads to inbreeding and loss of genetic diversity and so increases extinction risk. Captive populations of endangered species are managed to maximize the retention of genetic diversity by minimizing kinship, with subsidiary efforts to minimize inbreeding. There is growing evidence that genetic adaptation to captivity is a major issue in the genetic management of captive populations of endangered species as it reduces reproductive fitness when captive populations are reintroduced into the wild. This problem is not currently addressed, but it can be alleviated by deliberately fragmenting captive populations, with occasional exchange of immigrants to avoid excessive inbreeding. The extent and importance of outbreeding depression is a matter of controversy. Currently, an extremely cautious approach is taken to mixing populations. However, this cannot continue if fragmented populations are to be adequately managed to minimize extinctions. Most genetic management recommendations for endangered species arise directly, or indirectly, from quantitative genetic considerations. PMID:10689801

Frankham, R

1999-12-01

455

Quantitative imaging with fluorescent biosensors.  

PubMed

Molecular activities are highly dynamic and can occur locally in subcellular domains or compartments. Neighboring cells in the same tissue can exist in different states. Therefore, quantitative information on the cellular and subcellular dynamics of ions, signaling molecules, and metabolites is critical for functional understanding of organisms. Mass spectrometry is generally used for monitoring ions and metabolites; however, its temporal and spatial resolution are limited. Fluorescent proteins have revolutionized many areas of biology-e.g., fluorescent proteins can report on gene expression or protein localization in real time-yet promoter-based reporters are often slow to report physiologically relevant changes such as calcium oscillations. Therefore, novel tools are required that can be deployed in specific cells and targeted to subcellular compartments in order to quantify target molecule dynamics directly. We require tools that can measure enzyme activities, protein dynamics, and biophysical processes (e.g., membrane potential or molecular tension) with subcellular resolution. Today, we have an extensive suite of tools at our disposal to address these challenges, including translocation sensors, fluorescence-intensity sensors, and Förster resonance energy transfer sensors. This review summarizes sensor design principles, provides a database of sensors for more than 70 different analytes/processes, and gives examples of applications in quantitative live cell imaging. PMID:22404462

Okumoto, Sakiko; Jones, Alexander; Frommer, Wolf B

2012-02-13

456

Zur Kenntnis cyclischer Acylale, 18. Mitt.: Über die Einwirkung von Diazomethan auf substituierte Benzylidenmeldrumsäuren und ähnliche Verbindungen  

Microsoft Academic Search

Zusammenfassung Es wird die Reaktion der Kondensationsprodukte (1–3) vonMeldrumsäuren mit Diazomethan in Methanol\\/Äther beschrieben, die zu den Cyclopropanverbindungen1 b-3 b führt. Diese Reaktionsweise ist bekannt und auch nach quantenchemischen Berechnungen des einen von uns (P. Schuster) zu erwarten.

P. Schuster; F. Wessely; A. Stephen

1967-01-01

457

Vergleich von marokkanischen Kreide-Küstenaufschlüssen und Tiefseebohrungen (DSDP): Stratigraphie, Paläoenvironment und Subsidenz an einem passiven Kontinentalrand  

Microsoft Academic Search

Zusammenfassung  Wegen seiner guten Aufschlüsse in Küstenbecken bietet Marokko im Vergleich zu anderen Stellen rings um den Nordatlantik beste Voraussetzungen, die mesozoische und insbesondere kretazische Entwicklung am Kontinentalrand zu verfolgen und eine Verbindung zwischen ozeanischer und küstennaher Sedimentation und Stratigraphie herzustellen. Die Kreidesedimente der von S nach N aufeinander folgenden Küstenbecken von Tarfaya, Agadir, Essaouira und am Rand der Meseta werden

Jost Wiedmann; Arif Butt; Gerhard Einsele

1978-01-01

458

So That Love May Be Safeguarded: The Nature, Form, and Function of Obedience as a Heuristic Device for the Theology of Hans Urs Von Balthasar  

Microsoft Academic Search

Hans Urs von Balthasar's literary body of work is enormous. His style is erudite and often abstruse. As a result, it is often difficult to systematize and arrange his work into coherent and consistent categories. This dissertation offers the singular category of obedience as a heuristic device to help render the entire von Balthasarian corpus more understandable. For von Balthasar,

Daniel Paul Burns

2011-01-01

459

BOOK REVIEW: Meilensteine der Astronomie - Von Aristoteles bis Hawking  

NASA Astrophysics Data System (ADS)

A writer, more specific a writer on the history of astronomy, might from time to time look at the collected document folders with all the research material and reprints, and might wonder: has this been all? Especially at a time when recycling is in vogue? And, perhaps with a request or an invitation to submit something, he or she might consider re-using the material before its definitive disposal. Well, such are my feelings when I looked at Jurgen Hamel's new book Milestones of Astronomy - From Aristoteles to Hawking . A slight chance for survival of medium-sized publishers like Kosmos is to offer popular books, and a title must attract potential buyers: Aristoteles means the "old" times, and as concerns the "mad scientist" of modern times, Stephen Hawking has by now dethroned Einstein. In 1998, Hamel had published a Geschichte der Astronomie - Von den Anfangen bis zur Gegenwart (History of astronomy, from the beginnings to the present), which, of course, he could not simply copy. This time, he selected some stones from his research areas - milestones, touchstones, stumbling blocks in the long road of astronomical evolution - and put them between the covers of his new book. So let us look at these (mile)stones . The reader is informed about Aristoteles on 2 pages, but his medieval interpreter Johannes de Sacrobosco gets 8 pages! Copernicus' life and achievements are described on 9 pages, closely followed by his devotee and translator Rothmann with 8 pages; Copernicus' contemporary, Peter Apian, however, gets about 13! Bessel's and Herschel's lifes and works are described on well-deserved 13 and 15 pages, while the achievements of the two Lucasian professors, Isaac Newton and Stephen Hawking, are just outlined in a single paragraph! Thus, importance is sometimes inversely proportional to text length... But let us become serious now. Why should an active historian outline, for the hundreth time, the life of Copernicus, while there are so many interesting, and often neglected, other astronomers? Before the chapter dealing with Aristoteles and other Greek thinkers, the author presents a very good introduction to prehistoric astronomy. Subsequent chapters cover medieval times (Sacrobosco), Copernicus, instruments (Apian), calendars and their makers, telescopes and theological conflicts, women in astronomy and celestial mechanics, "amateur" astronomers (Herschel and Bessel), philosophy and science (Kant and successors). "At the limits of knowledge" is the title of the last, somewhat scanty chapter on 20th century astronomy. The only confusing text is found on p. 43: Die exzentrische Lage der Spharen wurde von Hipparch im 2. Jahrhundert v. Chr. eingefuhrt. Cum grano salis, this is correct; Hipparchos assumed an eccentric orbit for the Sun. Furthermore, die Erde steht im Mittelpunkt des Deferenten, jedoch um den Betrag der Exzentrizitat E vom Mittelpunkt des Exzenters entfernt. A figure showing a deferent circle (and attached epicycle) with center M, and a lower point E called center of world = center of Earth in the caption, tries to illustrate this. The desperate reader does not find the eccenter in the figure, and also does not appreciate why the Earth is in the center of the deferent M when the caption says it is in E. The explanation is that for a planet, having two anomalies, the epicycle does not run on a concentric circle, usually called deferent, but on an eccenter. Thus, in the figure, the circle labelled deferent is the eccenter. In Cellarius' Harmonia Macrocosmica, Table 14, a similar figure explains it all: Eccentricus deferens epicyclum - the eccenter that carries around the epicycle. Since we have switched to Latin, we should mention that on p. 158, we encountered the sentence "in dubia pro res". Perhaps we are permitted to reply "si tacuisses, philosophus mansisses". The reader is cautioned: if this book is used as a road atlas for the history of astronomy, the reader will often find very rough sketches of the progress of astronomy, but from time to time

Duerbeck, H. W.; Hamel, J.

2006-12-01

460

Static task of von Mises planar truss analyzed using the potential energy  

NASA Astrophysics Data System (ADS)

A Von Mises planar truss subjected to vertical static load at its top joint is studied. The mathematical concept of large displacement elastic analysis of the von Mises truss targeted for computers is described. The model geometry is described using finite mass points. Formulae for the evaluation of displacements of mass points and rotation of segments were derived with the help of geometrical and physical conditions. Formulae for the determination of potential energy of the system are listed. Deformation of the structure is evaluated by seeking the minimal potential energy. The step-by-step increment method combined with Newton-Raphson method is used. The mathematical solution described in the article enables the modelling of Mises truss using a finite amount of segments. The described solution is suitable for load-deflection curve computation of a limit load model. The equilibrium stability problem of von Mises truss is discussed in connection with the random effects of imperfections.

Kalina, Martin

2013-10-01

461

An Alternative to Von Glasersfeld's Subjectivism in Science Education: Deweyan Social Constructivism  

NASA Astrophysics Data System (ADS)

An influential view of constructivism in science and mathematics educational research and practice is that of Ernst von Glasersfeld. It is a peculiarly subjectivist form of constructivism that should not be attractive to science and mathematics educators concerned with retaining some sort of realism that leaves room for objectivity. The subjectivist constructivism of von Glasersfeld also becomes entangled in untenable mind/body and subject/object dualisms. Finally, these dualisms are unnecessary for social constructivism. I will provide one example of a social constructivist alternative to social constructivism, that of the pragmatic philosopher John Dewey. In presenting Dewey's position I will appeal to Ockham's razor, that is, the admonition not to multiply entities beyond necessity, to shave off the needless mentalistic and psychic entities that lead von Glasersfeld into his subjectivism and dualism.

Garrison, Jim

462

Dreams of death: Von Weizsäcker's Dreams in so-called endogenic anorexia: a research note.  

PubMed

Viktor Von Weizsäcker's paper "Dreams in so-called endogenic Magersucht (anorexia," first published in the Deutsche Medizinische Wochenschrift in 1937 (translation in M. Kaufman & M. Heiman [1964]. Evolution of psychosomatic concepts: Anorexia nervosa: A paradigm (pp. 181-197), New York: International Universities Press, has been described as a noteworthy and historically important contribution to the recognition of anorexia nervosa as a psychosomatic illness. Von Weizsäcker analyzed the dreams of patients he was treating for "endogenous anorexia" (magersucht). He claimed that in the bulimic phase his patients experienced nightmares dealing with themes of death, but that in the anorectic phases of restricted eating more pleasant dreams dealt with themes of blissful contentment. The authors draw current attention to his work as another early example of the treatment of the theme of death and death symbolism in the literature on eating disorders, and suggest some reappraisal of von Weizsäcker's interpretations of his own material. PMID:8477306

Jackson, C; Beumont, P J; Thornton, C; Lennerts, W

1993-04-01

463

Estimating the probability distribution of von Mises stress for structures undergoing random excitation. Part 1: Derivation  

SciTech Connect

The von Mises stress is often used as the metric for evaluating design margins, particularly for structures made of ductile materials. For deterministic loads, both static and dynamic, the calculation of von Mises stress is straightforward, as is the resulting calculation of reliability. For loads modeled as random processes, the task is different; the response to such loads is itself a random process and its properties must be determined in terms of those of both the loads and the system. This has been done in the past by Monte Carlo sampling of numerical realizations that reproduce the second order statistics of the problem. Here, the authors present a method that provides analytic expressions for the probability distributions of von Mises stress which can be evaluated efficiently and with good precision numerically. Further, this new approach has the important advantage of providing the asymptotic properties of the probability distribution.

Segalman, D.; Reese, G.

1998-09-01

464

Third Åland islands conference on von Willebrand disease, 26-28 September 2012: meeting report.  

PubMed

The first meeting of international specialists in the field of von Willebrand disease (VWD) was held in the Åland islands in 1998 where Erik von Willebrand had first observed a bleeding disorder in some members of a family from Föglö and a summary of the meeting was published in 1999. The second meeting was held in 2010 and a report of the meeting was published in 2012. Topics covered included progress in understanding of VWD over the last 50 years; multimers; classification of VWD; pharmacokinetics and laboratory assays; genetics; treating the paediatric patient; prophylaxis; geriatrics; gene therapy and treatment guidelines. This third meeting held over 3 days covered the structure and function of von Willebrand factor (VWF); type 1 VWD, the most common form of the disease; a lifespan of pharmacokinetics in VWD; detecting inhibitors in VWD patients; and special challenges in understanding and treating the female VWD patient. PMID:23383607

Berntorp, E; Fuchs, B; Makris, M; Montgomery, R; Flood, V; O'Donnell, J S; Federici, A B; Lillicrap, D; James, P; Budde, U; Morfini, M; Petrini, P; Austin, S; Kannicht, C; Jiménez-Yuste, V; Lee, C

2013-03-01

465

von Willebrand's disease in Mexico: a pilot study.  

PubMed

von Willebrand's disease (VWD) is the most commonly inherited bleeding disorder. For a long time, it has been said that VWD was absent in some countries due to ethnical differences. Information about the prevalence of VWD in Mexico remains unclear, owing largely to poor awareness and diagnosis of the disease. The aim of this study was to objectively diagnose VWD in a cohort of highly selected Mexican patients with a chronic history of bleeding. Mexican Mestizos were recruited between July 2010 and August 2011. Included were 133 adult and paediatric patients with a high suspicion of VWD. Fifty-three were diagnosed with VWD: 47 (88.7%) with type 1 VWD, four (7.5%) with type 2a VWD and two (3.8%) with type 3 VWD. Mean age for female patients was 19.5 years (range 3-44 years) and 18.5 years (range 4-63 years) for male patients. Mean age at start of bleeding symptoms was 8.8 years (range 1-61). The most frequent clinical symptoms were epistaxis (84.9%), ecchymosis (79.2%), haematomas (71.7%), gum bleeds (62.3%) and petechia (50.9%). Severe transoperative or postoperative bleeding was found in 17 patients (32.1%). Twenty-six women at childbearing age had a history of abnormal gynaecological bleeding. Our results clearly demonstrate the presence of VWD in Mexican and underscore the importance of a more detailed description of VWD. Efforts to increase the awareness and diagnosis of VWD could help in better identification of patients with bleeding disorders and lead to early, appropriate management with safe and efficacious therapies such as desmopressin and plasma concentrates. PMID:22989112

Majluf-Cruz, A; Velez-Ruelas, M A; Gonzalez-Avila, A I; Garcia-Chávez, J; Berges, A; Lopez-Santiago, N; Monroy-Garcia, R; Moreno-Hernandez, M; Corona-De La Peña, N; Alvarado-Moreno, J A; Isordia-Salas, I; Hernandez Juarez, J

2012-09-19

466

Plasma concentration of von Willebrand factor in acute myocardial infarction.  

PubMed

Recent investigations have revealed the crucial role of von Willebrand factor (vWF) in platelet thrombus formation under flow conditions. The plasma concentrations of vWF were measured together with various hemodynamic and hemostatic parameters in 51 cases of acute myocardial infarction. In 10 randomly selected cases, the plasma concentrations and distribution of multimers vWF were serially determined after reperfusion therapy by percutaneous transluminal coronary angioplasty (PTCA). The vWF concentration at the onset of the acute myocardial infarction was significantly higher than in an age-matched control group (vWF AG: 18.7 +/- 1.2 microg/ml vs. 10.3 +/- 0.5 microg/ml, p = 8.43 x 10-(12), mean +/- SE). Simultaneous determination of hemodynamic and hemostatic parameters revealed that the only two parameters that were significantly correlated with the patients' plasma vWF concentrations were their pulmonary capillary wedge pressure (PCWP) and heart rate, suggesting a relationship between hemodynamic changes induced by the onset of myocardial infarction and the vWF plasma concentrations. Serial determinations revealed that the vWF concentrations had not changed 1 h after reperfusion therapy, but that they significantly increased by 24 to 72 h. The distribution of the larger multimers of vWF also increased in the acute and subacute phase. The vWF concentration and multimer distribution normalized 14 days after the onset of the myocardial infarction. Our findings suggest that the vWF concentration increased in acute myocardial infarction patients, possibly in association with the hemodynamic deterioration that occurs in acute myocardial infarction. PMID:10959690

Sakai, H; Goto, S; Kim, J Y; Aoki, N; Abe, S; Ichikawa, N; Yoshida, M; Nagaoka, Y; Handa, S

2000-08-01

467

The Interaction between Factor H and Von Willebrand Factor.  

PubMed

Complement factor H (fH) is a plasma protein that regulates activation of the alternative pathway, and mutations in fH are associated with a rare form of thrombotic microangiopathy (TMA), known as atypical hemolytic uremic syndrome (aHUS). A more common TMA is thrombotic thrombocytopenic purpura, which is caused by the lack of normal ADAMTS-13-mediated cleavage of von Willebrand factor (VWF). We investigated whether fH interacts with VWF and affects cleavage of VWF. We found that factor H binds to VWF in plasma, to plasma-purified VWF, and to recombinant A1 and A2 domains of VWF as detected by co-immunoprecipitation (co-IP) and surface plasmon resonance assays. Factor H enhanced ADAMTS-13-mediated cleavage of recombinant VWF-A2 as determined by quantifying the cleavage products using Western-blotting, enhanced cleavage of a commercially available fragment of VWF-A2 (FRETS-VWF73) as determined by fluorometric assay, and enhanced cleavage of ultralarge (UL) VWF under flow conditions as determined by cleavage of VWF-platelet strings attached to histamine stimulated endothelial cells. Using recombinant full-length and truncated fH molecules, we found that the presence of the C-terminal half of fH molecule is important for binding to VWF-A2 and for enhancing cleavage of the A2 domain by ADAMTS-13. We conclude that factor H binds to VWF and may modulate cleavage of VWF by ADAMTS-13. PMID:23991205

Feng, Shuju; Liang, Xiaowen; Cruz, Miguel A; Vu, Hangoc; Zhou, Zhou; Pemmaraju, Naresh; Dong, Jing-Fei; Kroll, Michael H; Afshar-Kharghan, Vahid

2013-08-26

468

Disulfide Bond Reduction of Von Willebrand Factor by ADAMTS-13†  

PubMed Central

Summary Background von Willebrand factor (VWF) released from endothelial cells is rich in ultra-large (UL) multimers that are intrinsically active in binding platelets, whereas plasma-type VWF multimers require shear stress to be activated. This functional difference may be attributed to thiols exposed on the surface of plasma-type VWF multimers, but not on ULVWF multimers. Shear stress induces the exposed thiols to form disulfide bonds between laterally apposed plasma-type VWF multimers, leading to enhanced VWF binding to platelets. Objectives We tested a hypothesis that ADAMTS-13 has a disulfide bond-reducing activity that regulates shear-induced thiol-disulfide exchange of VWF. Methods Thiol blocking agents and active thiol bead capturing were used to identify and locate this activity; along with truncated ADAMTS-13 mutants. Results ADAMTS-13 contains a disulfide-bond–reducing activity that primarily targets disulfide bonds in plasma-type VWF multimers induced by high shear stress or formed with thiol beads, but not on disulfide bonds in native multimeric structures. Cysteine thiols targeted by this activity are in the VWF C-domain and are known to participate in shear-induced thiol-disulfide exchange. ADAMTS-13 contains cysteine thiols that remain exposed after being subjected to hydrodynamic forces. Blocking these active thiols eliminates this reducing activity and moderately decreases ADAMTS-13 activity in cleaving ULVWF strings anchored to endothelial cells under flow conditions, but not under static conditions. The activity is located in the C-terminal region of ADAMTS-13. Conclusions This novel disulfide-bond-reducing activity of ADAMTS-13 may prevent covalent lateral association and increased platelet adherence of plasma-type VWF multimers induced by high fluid shear stress.

Yeh, Hui-Chun; Zhou, Zhou; Choi, Hiuwan; Tekeoglu, Senem; May, William; Wang, Christina; Turner, Nancy; Scheiflinger, Friedrich; Moake, Joel L.; Dong, Jing-fei

2010-01-01

469

Functional anatomy of cortical areas characterized by Von Economo neurons.  

PubMed

Von Economo's neurons (VENs) are large, bipolar or corkscrew-shaped neurons located in layers III and V of the frontoinsular and the anterior cingulate cortices. VENs are reported to be altered in pathologies such as frontotemporal dementia and autism, in which the individual's self control is seriously compromised. To investigate the role of VENs in the active human brain, we have explored the functional connectivity of brain areas containing VENs by analyzing resting state functional connectivity (rsFC) in 20 healthy volunteers. Our results show that cortical areas containing VENs form a network of frontoparietal functional connectivity. With the use of fuzzy clustering techniques, we find that this network comprises four sub-networks: the first network cluster resembles a "saliency detection" attentional network, which includes superior frontal cortex (Brodmann's Area, BA 10), inferior parietal lobe, anterior insula, and dorsal anterior cingulate cortex; the second cluster, part of a "sensory-motor network", comprises the superior temporal, precentral and postcentral areas; the third cluster consists of frontal ventromedial and ventrodorsal areas constituted by parts of the "anterior default mode network"; and the fourth cluster encompasses dorsal anterior cingulate cortex, dorsomedial prefrontal, and superior frontal (BA 10) areas, resembling the anterior part of the "dorsal attentional network". Thus, the network that emerges from analyzing functional connectivity among areas that are known to contain VENs is primarily involved in functions of saliency detection and self-regulation. In addition, parts of this network constitute sub-networks that partially overlap with the default mode, the sensory-motor and the dorsal attentional networks. PMID:22286950

Cauda, Franco; Torta, Diana M E; Sacco, Katiuscia; D'Agata, Federico; Geda, Elisabetta; Duca, Sergio; Geminiani, Giuliano; Vercelli, Alessandro

2013-01-01

470

Darstellung von LTK-Läsionen durch optische Kurzkohärenztomographie (OCT) und Polarisationsmikroskopie nach Sirius-Rot-Färbung  

Microsoft Academic Search

  \\u000a Hintergrund: Für die Kontrolle der Laserdosis und der postoperativen Entwicklung bei Laserthermokeratoplastik (LTK) sind Informationen\\u000a über die Ausdehnung und das Ausmaß der thermischen Läsionen von großer Bedeutung. Wir verglichen den Informationsgehalt der\\u000a Darstellung frischer LTK-Läsionen durch Optische Kurzkohärenztomographie [optical low coherence tomography (OCT)] mit der\\u000a histologischen Darstellung durch Polarisationsmikroskopie.\\u000a \\u000a \\u000a \\u000a Methode: Die Kornea von Schweineaugen wurde in vitro durch eine

Mary N. Asiyo-Vogel; Norbert Koop; Ralf Brinkmann; Ralf Engelhardt; Reinhard Eggers; Reginald Birngruber; Alfred Vogel

1997-01-01

471

Instrumentation for Studies of Cochlear Mechanics: From von B?k?sy forward  

PubMed Central

Georg von Békésy designed the instruments needed for his research. He also created physical models of the cochlea allowing him to manipulate the parameters (such as volume elasticity) that could be involved in controlling traveling waves. This review is about the specific devices that he used to study the motion of the basilar membrane thus allowing the analysis that lead to his Nobel Prize Award. The review moves forward in time mentioning the subsequent use of von Békésy’s methods and later technologies important for motion studies of the organ of Corti. Some of the seminal findings and the controversies of cochlear mechanics are mentioned in relation to the technical developments.

Nuttall, Alfred L; Fridberger, Anders

2012-01-01

472

Komorbide depressive Störungen als Mediator der Assoziation von Misshandlungen in Kindheit\\/Jugend und Fibromyalgiesyndrom  

Microsoft Academic Search

Zusammenfassung\\u000a Hintergrund  Emotionale und körperliche Misshandlungen in Kindheit und Jugend („childhood maltreatments“, CMs) werden als mögliche ätiologische\\u000a Faktoren des Fibromyalgiesyndroms (FMS) diskutiert. Bisher wurde nicht überprüft, ob die Assoziation von CMs und FMS durch\\u000a Mediatoren bedingt ist.\\u000a \\u000a \\u000a \\u000a \\u000a Methode  CMs von konsekutiven FMS-Patienten aus 3 verschiedenen klinischen Kontexten wurden mit der deutschen Version des Childhood\\u000a Trauma Questionnaire erfasst. Als mögliche Mediatoren wurden klinisches

M. Kosseva; S. Schild; R. Wilhelm-Schwenk; W. Biewer; W. Häuser

2010-01-01

473

Von Kärmauml5;n's Work: The Later Years (1952 to 1963) and Legacy  

NASA Astrophysics Data System (ADS)

In view of the earlier publication in this journal of a biography of Theodore von Kärmän by Sears & Sears (1979), which referred to his years in Germany at Güttingen (1908 to 1912) and Aachen (1912 to 1930) and at the Guggenheim Aeronautical Laboratory of the California Institute of Technology (GALCIT) from 1930 to 1952, we restrict our review here to his later years (from 1952 until his death in 1963). We also comment on his scientific legacy and identify representative institutions and outstanding workers whose research continues the von Kärmän style of work in the general areas of aerothermochemistry and allied fields.

Penner, S. S.; Williams, F. A.; Libby, P. A.; Nemat-Nasser, S.

2009-01-01

474

Hypopituitarism, deficiency of factors V and VIII and von Willebrand factor: an uncommon association.  

PubMed

A 9 year-old boy with hypopituitarism and blood coagulation abnormalities is presented and discussed. The association between acquired von Willebrand disease and hypothyroidism has been reported but the combination of hypopituitarism and coagulopathy is unusual. Combined multiple clotting deficiencies are rare and, when present, factors V and VIII is the commonest association. Although it is known that hypothyroid patients may have a decrease in von Willebrand's factor (vWf) and factor VIII, there are no reports of hypopituitarism associated with combined deficiency of factors V, VIII, and vWf. PMID:11926206

Setian, Nuvarte; Tanaka, Caroline M; Damiani, Durval; Dichtchekenian, Vaê; Carneiro, Jorge D A; D'Amico, Elbio A

2002-03-01

475

[Applications of 'quantitative sensory testing'].  

PubMed

Quantitative sensory testing (QST) consists of several non-invasive, standardised tests aimed at examining different aspects of the entire somatosensory nervous system. Important advantages of QST over existing supplementary tests such as electromyography are the ability to test the function of thin and unmyelinated nerve fibres as well as the subjective sensation of a somatosensory stimulus. QST is validated in diagnosing small fibre neuropathy, diabetic neuropathy chemotherapy-induced peripheral neuropathy and neuropathic pain. In scientific research, QST is useful in the study into pathophysiological mechanisms of diseases and syndromes with sensory symptoms and in the evaluation of the effect of analgesic treatment on the function of the somatosensory nervous system. In the future, QST could be a useful diagnostic and prognostic test in more forms of neuropathy and in other clinical conditions such as chronic unexplained pain syndromes (e.g. fibromyalgia and whiplash-associated disorder. PMID:23369816

Verberne, Wouter R; Snijders, Tom J; Liem, K Seng; Baakman, Anne Catrien; Veldhuijzen, Dieuwke S

2013-01-01

476

Increased plasma von Willebrand factor antigen levels but normal von Willebrand factor cleaving protease (ADAMTS13) activity in preeclampsia.  

PubMed

The activity of ADAMTS13, the von Willebrand factor (VWF) cleaving protease is low in several conditions, including HELLP (haemolysis, elevated liver enzymes, and low platelet count) syndrome. As HELLP syndrome develops in most cases on the basis of preeclampsia, our aim was to determine whether plasma ADAMTS13 activity is decreased in preeclampsia. Sixty-seven preeclamptic patients, 70 healthy pregnant women and 59 healthy non-pregnant women were involved in this case-control study. Plasma ADAMTS13 activity was determined with the FRETS-VWF73 assay, while VWF antigen (VWF:Ag) levels with an enzyme-linked immunosorbent assay. The multimeric pattern of VWF was analyzed by SDS-agarose gel electrophoresis. There was no significant difference in plasma ADAMTS13 activity between the preeclamptic and the healthy pregnant and non-pregnant groups (median [25-75 percentile]: 98.8 [76.5-112.8] %, 96.3 [85.6-116.2] % and 91.6 [78.5-104.4] %, respectively; p > 0.05). However, plasma VWF:Ag levels were significantly higher in preeclamptic patients than in healthy pregnant and non-pregnant women (187.1 [145.6-243.1] % versus 129.3 [105.1-182.8] % and 70.0 [60.2-87.3] %, respectively; p < 0.001). The multimeric pattern of VWF was normal in each group. Primiparas had lower plasma ADAMTS13 activity than multi-paras (92.6 [75.8-110.6] % versus 104.2 [92.1-120.8] %; p = 0.011). No other relationship was found between clinical characteristics, laboratory parameters and plasma ADAMTS13 activity in either study group. In conclusion, plasma ADAMTS13 activity is normal in preeclampsia despite the increased VWF:Ag levels. However, further studies are needed to determine whether a decrease in plasma ADAMTS13 activity could predispose preeclamptic patients to develop HELLP syndrome. PMID:19190814

Molvarec, Attila; Rigó, János; Bõze, Tamás; Derzsy, Zoltán; Cervenak, László; Makó, Veronika; Gombos, Tímea; Udvardy, Miklós László; Hársfalvi, Jolán; Prohászka, Zoltán

2009-02-01

477

A standard nomenclature for von Willebrand factor gene mutations and polymorphisms. On behalf of the ISTH SSC Subcommittee on von Willebrand factor.  

PubMed

Examination of the entire von Willebrand factor (VWF) gene for mutations, particularly in types 1 and 3 von Willebrand disease (VWD) is becoming more widely practised. The sequence of the entire VWF gene will soon be compiled as a single sequence. For these reasons, a clearly defined nomenclature to use for numbering the VWF nucleotide and amino acid sequence is required. The following recommendations are made for VWF numbering. VWF cDNA nucleotide sequence should be numbered from the A of the initiator ATG as the +1 position. Genomic DNA should be prefixed with a "g" and also numbered from this position. Amino acid (aa) numbering should be from the initiator methionine as the +1 position with sequential numbering of aa throughout VWF. To avoid confusion with previously used numbering schemes for mature VWF, which started from serine 764 of pre-pro VWF, the use of the single letter amino acid code is recommended. PMID:11372690

Goodeve, A C; Eikenboom, J C; Ginsburg, D; Hilbert, L; Mazurier, C; Peake, I R; Sadler, J E; Rodeghiero, F

2001-05-01

478

von Hippel-Lindau gene deletion detected in the stromal cell component of a cerebellar hemangioblastoma associated with von Hippel-Lindau disease  

Microsoft Academic Search

Central nervous system hemangioblastoma is a neoplasm with characteristic and well-described histopathological features, including proliferation of vascular and stromal cells. Yet, the histogenesis of the stromal cell component and its neoplastic capacity as compared with the vascular component are still controversial. Stromal cells were selectively procured from formalin-fixed, paraffin-embedded archival tissue from a von Hippel-Lindau (VHL) disease patient with a

A. O Vortmeyer; J. R Gnarra; M. R Emmert-Buck; D Katz; W. M Linehan; E. H Oldfield; Z Zhuang

1997-01-01

479

DISPROPORTIONIERUNGEN VON DIPHENYL-DISULFIDEN ZU 1.2-BENZISOTHIAZOLEN UND o-SUBSTITUIERTEN THIOPHENOLEN UNTER ANCHIMERER BETEILIGUNG VON ORTHOSTÄNDIGEN AMID, THIOAMID UND AMIDIN-GRUPPEN  

Microsoft Academic Search

Substituents in the ortho position provide anchimeric support in the dissociation of diphenylsulphides. The carbamoyl group has only a weak effect. Support increases from an N,N?-disubstituted guanyl group, over thioamide to a guanyl group with an unsubstituted nitrogen atom, which effects an almost completely reversible cleavage of the disulphide group.Die Dissoziation der Diphenyldisulfide wird von orthoständigen Substituenten anchimer unterstützt. Die

H. Böshagen; W. Geiger

1983-01-01

480

Answering Critical Questions Using Quantitative Data  

ERIC Educational Resources Information Center

|Drawing on the work of several prominent scholars, the author describes the evolution of quantitative critical inquiry and compares this perspective to traditional research paradigms. (Contains 1 table.)|

Stage, Frances K.

2007-01-01

481

Gene for Von Recklinghausen Neurofibromatosis is in the Pericentromeric Region of Chromosome 17  

Microsoft Academic Search

Linkage analysis of 15 Utah kindreds demonstrated that a gene responsible for von Recklinghausen neurofibromatosis (NF) is located near the centromere on chromosome 17. The families also gave no evidence for heterogeneity, indicating that a significant proportion of NF cases are due to mutations at a single locus. Further genetic analysis can now refine this localization and may lead to

D. Barker; E. Wright; K. Nguyen; L. Cannon; P. Fain; D. Goldgar; D. T. Bishop; J. Carey; B. Baty; J. Kivlin; H. Willard; J. S. Waye; G. Greig; L. Leinwand; Y. Nakamura; P. O'Connell; M. Leppert; J.-M. Lalouel; R. White; M. Skolnick

1987-01-01

482

Coats' Disease, Turner Syndrome, and von Willebrand Disease in a Patient with Wildtype Norrie Disease Pseudoglioma.  

PubMed

The authors describe a girl diagnosed as having Coats' disease, Turner syndrome (45X karyotype), and type 1 von Willebrand disease. She tested negative for the Norrie disease pseudoglioma (NDP) gene located on the X-chromosome, which has been suspected of contributing to Coats' disease. PMID:20411871

Desai, Rajen U; Saffra, Norman A; Krishna, Rati P; Rosenberg, Steven E

2010-03-26