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Sample records for r process

  1. Physical conditions for the r-process

    NASA Astrophysics Data System (ADS)

    Wanajo, S.; Tachibana, T.; Goriely, S.

    2012-11-01

    Recent works show that the r-process can proceed by competition between neutron capture and β-decay in low temperature environments (< 5 × 108 K; cold r-process) where photo-disintegration plays no role. This is in contrast to the traditional picture of the r-process in high temperature environments (~ 1 × 109 K; hot r-process) where the (n, γ)-(γ, n) equilibrium holds. In this study, we explore nucleosynthesis calculations based on a site-independent model to elucidate the physical conditions leading to cold and hot r-processes.

  2. Physical conditions for the r-process

    SciTech Connect

    Wanajo, S.; Tachibana, T.; Goriely, S.

    2012-11-12

    Recent works show that the r-process can proceed by competition between neutron capture and {beta}-decay in low temperature environments (< 5 Multiplication-Sign 10{sup 8} K; cold r-process) where photo-disintegration plays no role. This is in contrast to the traditional picture of the r-process in high temperature environments ({approx} 1 Multiplication-Sign 10{sup 9} K; hot r-process) where the (n, {gamma})-({gamma}, n) equilibrium holds. In this study, we explore nucleosynthesis calculations based on a site-independent model to elucidate the physical conditions leading to cold and hot r-processes.

  3. The r-PROCESS Record in Meteorites

    NASA Astrophysics Data System (ADS)

    Davis, Andrew M.

    2004-09-01

    The r-process record in bulk meteorites and components of primitive meteorites (including refractory inclusions and presolar grains) is reviewed. Small r-process excesses are seen in bulk meteorites and refractory inclusions. Large r-process enhancements have only been observed in presolar diamond. The unique properties and formation conditions of presolar diamond, high purity and high surface-to-volume ratio, may allow it to preserve an r-process signature. It is suggested that the conditions under which r-process matter is ejected from a nascent neutron star dictate that apart from diamonds, strong r-process enhancements are not to be expected in larger presolar grains and other solar system components.

  4. A new r-process star with low abundances of r-process elements

    NASA Astrophysics Data System (ADS)

    Frebel, A.; Yu, Q.; Jacobson, H. R.

    2016-01-01

    Metal-poor stars with measurable r-process element abundances provide key clues to the production site(s) of the r-process and how its products are mixed with the surrounding medium. While the number of stars exhibiting strong enhancements of r-process elements has grown over the years, the lower “floor” of r-process enrichment in metal-poor stars has yet to be established, largely in part due to the difficulty in detecting weak neutron-capture element absorption lines in stellar spectra. Here we present detailed abundances of 16 neutron-capture elements for a star exhibiting the lowest level of r-process enrichment yet detected and still following the solar system r-process pattern. Taken into consideration with most of the r- process enriched stars currently in the literature, the range of r-process element enrichment spanned by this sample is at least ∼1.3dex or a factor of more than 20. That the r-process abundance pattern is unchanged while the degree of enrichment varies may suggest that the r- process yields are constant while the gas mass into which they are mixed varies. Given that all stars have similar [Fe/H] values then suggests that only one or few previous stellar generations provided the observed chemical abundances, meaning that perhaps only one r-process event occurred prior to their formation. This would be consistent with a (near) constant r-process yield per event. Obtaining detailed element abundances for stars with mild r-process element enhancements is necessary to better constrain the ubiquity of the r-process pattern, the yields of r-process elements, and the site of its production.

  5. R-process Nucleosynthesis in Supernova Explosion

    SciTech Connect

    Saruwatari, M.; Hashimoto, M.; Kotake, K.; Yamada, S.

    2011-10-28

    We investigate the possibility of the r-process during the magnetohydrodynamical (MHD) explosion of supernova in a massive star of 13 M{sub {center_dot}} with the effects of neutrinos included. Contrary to the case of the spherical explosion, jet-like explosion due to the combined effects of rotation and magnetic field lowers the electron fraction significantly inside the layers. We find that the ejected material of low electron fraction responsible for the r-process comes out from the inner deep region of the core that is made up of iron-group nuclei. This leads to the production of the second to third peak in the solar r-process elements. We suggest that there are some variations in the r-process nucleosynthesis according to the initial conditions of rotational and magnetic fields.

  6. r-Process in Neutron Star Mergers.

    PubMed

    Freiburghaus; Rosswog; Thielemann

    1999-11-10

    The production site of the neutron-rich heavy elements that are formed by rapid neutron capture (the r-process) is still unknown despite intensive research. Here we show detailed studies of a scenario that has been proposed earlier by Lattimer & Schramm, Symbalisty & Schramm, Eichler et al., and Davies et al., namely the merger of two neutron stars. The results of hydrodynamic and full network calculations are combined in order to investigate the relevance of this scenario for r-process nucleosynthesis. Sufficient material is ejected to explain the amount of r-process nuclei in the Galaxy by decompression of neutron star material. Provided that the ejecta consist of matter with a proton-to-nucleon ratio of Ye approximately 0.1, the calculated abundances fit the observed solar r-pattern excellently for nuclei that include and are heavier than the A approximately 130 peak. PMID:10525469

  7. The R-process and nucleochronology

    NASA Astrophysics Data System (ADS)

    Cowan, John J.; Thielemann, Friedrich-Karl; Truran, James W.

    1991-11-01

    The r-process of nucleosynthesis is the process which is responsible for the synthesis of approximately half of the nuclear species in nature that are more massive than iron. This process of heavy-element synthesis involves the progressive buildup of heavier isotopes via neut ron captures proceeding on neutron-rich isotopes, interspersed by beta decays. Its abudance features clearly reflect nuclear propeties - the maxima are related to the magic neutron numbers N = 50, 82 and 126. It probes our knowledge of the properties of nuclei far from the region of beta stability, even through the position of the neutron drip line. The r-process also forms the important long-lived nuclear chronometers 232Th, 238U and 235U that are utilized for dating the Galaxy. While the astrophysical site foprocess nucleosynthesis is not yet identified, its association with massive stars undergoing type II supernova events is strongly suggested. This can be deduced from the observation that r-process nuclei are already present in the oldest and most metal-deficient stars, which are the tracers of the chemical evolution of the Galaxy. The massive stars that become type II supernovae evolve fastest and contribute their ejecta to the interstellar medium at the earliest beginnings of the chemical evolution of the Galaxy. When utilizing the knowledge of the r-process production ratios of the long-lived chronometer nuclei, their observed ratios in primitive meteorites and our (limited) knowledge of star formation throughout galactic evolution, one can put limits on the duration of galactic nucleosynthesis, the age of the Galaxy and the universe. The latter has a large uncertainty but is comparable with ages estimated from globular clusters and cosmology. This paper will provide a review of the basic physics underlying the r-process, the operation of the mechanisms for r-process nucleosynthesis, the possible astrophysical sites, their time evolution in galactic evolution models, and the inferred ages of the Galaxy.

  8. Fission cycling in a supernova r process

    NASA Astrophysics Data System (ADS)

    Beun, J.; McLaughlin, G. C.; Surman, R.; Hix, W. R.

    2008-03-01

    Recent halo star abundance observations exhibit an important feature of consequence to the r process: the presence of a main r process between the second and third peaks that is consistent among halo stars. We explore fission cycling and steady β flow as the driving mechanisms behind this feature. The presence of fission cycling during the r process can account for nucleosynthesis yields between the second and third peaks, whereas the presence of steady β flow can account for consistent r-process patterns, robust under small variations in astrophysical conditions. We employ the neutrino-driven wind of the core-collapse supernova to examine fission cycling and steady β flow in the r process. As the traditional neutrino-driven wind model does not produce the required very neutron-rich conditions for these mechanisms, we examine changes to the neutrino physics necessary for fission cycling to occur in the neutrino-driven wind environment, and we explore under what conditions steady β flow is obtained.

  9. Superheavy elements and r-process

    SciTech Connect

    Panov, I. V. Korneev, I. Yu.; Thielemann, F.-K.

    2009-06-15

    The probability for the production of superheavy elements in the astrophysical r-process is discussed. The dependence of the estimated superheavy-element yields on input data is estimated. Preliminary calculations revealed that the superheavy-element yields at the instant of completion of the r-process may be commensurate with the uranium yield, but the former depend strongly on the models used to forecast the properties of beta-delayed, neutron-induced, and spontaneous fission. This study is dedicated to the 80th anniversary of V.S. Imshennik's birth.

  10. Rapid Business Process Discovery (R-BPD)

    NASA Astrophysics Data System (ADS)

    Ghose, Aditya; Koliadis, George; Chueng, Arthur

    Modeling is an important and time consuming part of the Business Process Management life-cycle. An analyst reviews existing documentation and queries relevant domain experts to construct both mental and concrete models of the domain. To aid this exercise, we propose the Rapid Business Process Discovery (R-BPD) framework and prototype tool that can query heterogeneous information resources (e.g. corporate documentation, web-content, code e.t.c.) and rapidly construct proto-models to be incrementally adjusted to correctness by an analyst. This constitutes a departure from building and constructing models toward just editing them. We believe this rapid mixed-initiative modeling will increase analyst productivity by significant orders of magnitude over traditional approaches. Furthermore, the possibility of using the approach in distributed and real-time settings seems appealing and may help in significantly improving the quality of the models being developed w.r.t. being consistent, complete, and concise.

  11. The r-process in Magnetorotational Supernovae

    NASA Astrophysics Data System (ADS)

    Tsujimoto, Takuji; Nishimura, Nobuya

    2015-09-01

    One of the hottest open issues involving the chemical evolution of r-process elements is fast enrichment in the early universe. Clear evidence for the chemical enrichement of r-process elements is seen in the stellar abundances of extremely metal poor stars in the Galactic halo. However, small-mass galaxies are the ideal testbed for studying the evolutionary features of r-process enrichment given the potential rarity of production events yielding heavy r-process elements. Their occurrences become countable and thus an enrichment path due to each event can be found in the stellar abundances. We examine the chemical feature of Eu abundance at an early stage of [Fe/H] ≲ -2 in the Draco and Sculptor dwarf spheroidal (dSph) galaxies. Accordingly, we constrain the properties of Eu production in the early dSphs. We find that the Draco dSph experienced a few Eu production events, whereas Eu enrichment took place more continuously in the Sculptor dSph due to its larger stellar mass. The event rate of Eu production is estimated to be about one per 100-200 core-collapse supernovae, and a Eu mass of ˜ (1-2) × 10-5M⊙ per single event is deduced by associating this frequency with the observed plateau value of [Eu/H] ˜ -1.3 for [Fe/H] ≳ -2. The observed plateau implies that early Eu enrichment ceases at [Fe/H] ≈ -2. Such a selective operation only in low-metallicity stars supports magnetorotational supernovae, which require very fast rotation, as the site of early Eu production. We show that the Eu yields deduced from chemical evolution agree well with the nucleosynthesis results from corresponding supernovae models.

  12. Astrophysical models of r-process nucleosynthesis: An update

    SciTech Connect

    Qian Yongzhong

    2012-11-12

    An update on astrophysical models for nucleosynthesis via rapid neutron capture, the r process, is given. A neutrino-induced r process in supernova helium shells may have operated up to metallicities of {approx} 10{sup -3} times the solar value. Another r-process source, possibly neutron star mergers, is required for higher metallicities.

  13. Sensitivity studies for the weak r process: neutron capture rates

    SciTech Connect

    Surman, R.; Mumpower, M.; Sinclair, R.; Jones, K. L.; Hix, W. R.; Physics Division, Oak Ridge National Laboratory, Oak Ridge, TN 37831 ; McLaughlin, G. C.

    2014-04-15

    Rapid neutron capture nucleosynthesis involves thousands of nuclear species far from stability, whose nuclear properties need to be understood in order to accurately predict nucleosynthetic outcomes. Recently sensitivity studies have provided a deeper understanding of how the r process proceeds and have identified pieces of nuclear data of interest for further experimental or theoretical study. A key result of these studies has been to point out the importance of individual neutron capture rates in setting the final r-process abundance pattern for a ‘main’ (A ∼ 130 peak and above) r process. Here we examine neutron capture in the context of a ‘weak’ r process that forms primarily the A ∼ 80 r-process abundance peak. We identify the astrophysical conditions required to produce this peak region through weak r-processing and point out the neutron capture rates that most strongly influence the final abundance pattern.

  14. THE RARE EARTH PEAK: AN OVERLOOKED r-PROCESS DIAGNOSTIC

    SciTech Connect

    Mumpower, Matthew R.; McLaughlin, G. C.; Surman, Rebecca E-mail: gail_mclaughlin@ncsu.edu

    2012-06-20

    The astrophysical site or sites responsible for the r-process of nucleosynthesis still remains an enigma. Since the rare earth region is formed in the latter stages of the r-process, it provides a unique probe of the astrophysical conditions during which the r-process takes place. We use features of a successful rare earth region in the context of a high-entropy r-process (S {approx}> 100k{sub B} ) and discuss the types of astrophysical conditions that produce abundance patterns that best match meteoritic and observational data. Despite uncertainties in nuclear physics input, this method effectively constrains astrophysical conditions.

  15. New Observational Perspectives on r-process Nucleosynthesis

    NASA Astrophysics Data System (ADS)

    Roederer, Ian U.

    2012-10-01

    Elements heavier than the iron group can be found in nearly every star whose abundances have been studied in detail. More than 60 percent of the naturally-occurring elements between zinc and uranium have been detected in r-process enriched stars. Models of the r-process rely heavily on matching astronomical observations, so this is good news for studies of r-process nucleosynthesis. I will highlight some of what we've learned from three decades of studying r-process material in other stars, describe current efforts that use the Hubble Space Telescope to expand the chemical inventory in r-process environments beyond the Solar system, and note opportunities for complementary studies by the physics community.

  16. THE R-PROCESS: Observations, models and unresolved issues

    NASA Astrophysics Data System (ADS)

    Cowan, John

    2002-10-01

    An overview of the the rapid neutron capture process (i.e., the r-process) will be presented. Abundances of these neutron-capture nuclei and elements in solar system material will first be compared with elemental and isotopic abundance patterns in certain galactic halo stars. These comparisons can then be used to identify the types of conditions and to constrain various models for the formation of the r-process nuclei. The models and comparisons will also be discussed in the context of the remaining problems and open questions in the r-process. These include the general lack of nuclear data for the most neutron-rich nuclei and the critical nature of the nuclear mass formulae; differences in the production of the heavier (above barium) and lighter neutron-capture elements; and the uncertainties in identifying the actual astrophysical site for the r-process and the evidence for, and the possible existence of, more than one such site.

  17. Neutron Capture Rates and r-PROCESS Nucleosynthesis

    NASA Astrophysics Data System (ADS)

    Surman, R. A.; Mumpower, M. R.; McLaughlin, G. C.; Sinclair, R.; Hix, W. R.; Jones, K. L.

    2013-03-01

    Simulations of r-process nucleosynthesis require nuclear physics information for thousands of neutron-rich nuclear species from the line of stability to the neutron drip line. While arguably the most important pieces of nuclear data for the r-process are the masses and β decay rates, individual neutron capture rates can also be of key importance in setting the final r-process abundance pattern. Here we consider the influence of neutron capture rates in forming the A ~ 80 and rare earth peaks.

  18. Impact of nuclear fission on r-process nucleosynthesis and origin of solar r-process elements

    SciTech Connect

    Shibagaki, Shota; Kajino, Toshitaka; Mathews, Grant J.; Chiba, Satoshi

    2015-02-24

    Binary neutron star mergers (NSMs) are expected to be main production sites of r-process elements. Their ejecta are extremely neutron-rich (Y{sub e}<0.1), and the r-process path proceeds along the neutron drip line and enters the region of fissile nuclei. In this situation, although superheavy nuclei may be synthesized and the r-process path may reach the island of stability, those are sensitive to theoretical models of nuclear masses and nuclear fission. In this study, we carry out r-process nucleosynthesis simulations in the NSMs. Our new nuclear reaction network code include new theoretical models of nuclear masses and nuclear fission. Our r-process simulation of a binary NSM shows that the final r-process elemental abundances exhibit flat pattern for A∼110-160, and several fission cycling operate in extremely neutron-rich conditions of the NSM. We find that the combination of the NSMs and the magnetorotational supernovae can reproduce the solar r-process elements. We discuss the validity of this interpretation.

  19. Impact of Nuclear Mass Uncertainties on the r Process

    NASA Astrophysics Data System (ADS)

    Martin, D.; Arcones, A.; Nazarewicz, W.; Olsen, E.

    2016-03-01

    Nuclear masses play a fundamental role in understanding how the heaviest elements in the Universe are created in the r process. We predict r -process nucleosynthesis yields using neutron capture and photodissociation rates that are based on the nuclear density functional theory. Using six Skyrme energy density functionals based on different optimization protocols, we determine for the first time systematic uncertainty bands—related to mass modeling—for r -process abundances in realistic astrophysical scenarios. We find that features of the underlying microphysics make an imprint on abundances especially in the vicinity of neutron shell closures: Abundance peaks and troughs are reflected in trends of neutron separation energy. Further advances in the nuclear theory and experiments, when linked to observations, will help in the understanding of astrophysical conditions in extreme r -process sites.

  20. Impact of Nuclear Mass Uncertainties on the r Process.

    PubMed

    Martin, D; Arcones, A; Nazarewicz, W; Olsen, E

    2016-03-25

    Nuclear masses play a fundamental role in understanding how the heaviest elements in the Universe are created in the r process. We predict r-process nucleosynthesis yields using neutron capture and photodissociation rates that are based on the nuclear density functional theory. Using six Skyrme energy density functionals based on different optimization protocols, we determine for the first time systematic uncertainty bands-related to mass modeling-for r-process abundances in realistic astrophysical scenarios. We find that features of the underlying microphysics make an imprint on abundances especially in the vicinity of neutron shell closures: Abundance peaks and troughs are reflected in trends of neutron separation energy. Further advances in the nuclear theory and experiments, when linked to observations, will help in the understanding of astrophysical conditions in extreme r-process sites. PMID:27058066

  1. Variances in r-process predictions from uncertain nuclear rates

    NASA Astrophysics Data System (ADS)

    Mumpower, Matthew; Surman, Rebecca; Aprahamian, Ani

    2015-04-01

    Rapid neutron capture or ‘r-process’ nucleosynthesisis a critical process for creating approximately half of heavy elements above iron in the Universe. Simulations of the r- process require theoretical calculations of neutron capture and, β-decay rates for thousands of short-lived nuclei for which no experimental data exists. We explore the impact of uncertainties in theoretical nuclear rates by performing global monte carlo simulations. We show that randomly varying neutron capture and β-decay rates within current theoretical model uncertainties results in large error bars for r-process predictions. We conclude that the reduction of rate uncertainties either by new measurements or by improved nuclear models will allow for more robust r-process predictions.

  2. The R-process, nucleosynthesis, and new nuclear masses

    NASA Astrophysics Data System (ADS)

    Paul, Nancy

    2009-10-01

    Precise, accurate measurements of nuclear masses are crucial for astrophysical modeling, reproducing the observed solar abundances of the elements, and for disentangling the nuclear physics imprinted on those abundances. More generally, masses are necessary for understanding nucleosynthesis via the r-process, thought to be responsible for over 50% of the elements heavier than Iron. The advent of ion traps and storage rings has generated a profusion of very precise measurements since the 2003 Atomic Mass Evaluation. I compiled an up-to-date list of new measurements from labs worldwide and incorporated them into Bradley Meyer's (Clemson University) classical model of the r-process to examine the impact of the new measurements. Sensitivity studies of various theoretical mass models and the new measurements in the r-process code, showed the largest deviations in the A=70-85 mass region. These studies will be used to plan new measurements of nuclei along the r-process path, near ^78Ni.

  3. Barium from a mini r-process in supernovae

    NASA Technical Reports Server (NTRS)

    Heymann, D.

    1983-01-01

    McCulloch and Wasserburg (1978) have reported nonlinear isotopic anomalies in barium for two Ca-Al-rich inclusions of the Allende carbonaceous chondrite, known as EK-1-4-1 and C-1. In an attempt to account for these anomalies, it has been proposed that Ba from an r-process of nucleosynthesis, containing Ba-135 and Ba-137, was injected into the primeval color system but was not totally homogenized. Questions arise in connection with the relations of Xe isotopes in carbonaceous chondrites. This has prompted Heymann and Dziczkaniec (1979, 1980, 1981) to study the formation of r-Xe, r-Kr, and r-Te by the mini r-process which is thought to occur in the O, Ne-rich shells of Type II supernovae. Lee et al. (1979) have studied the formation of r-Ba, r-Nd, and r-Sm by the same process. Certain differences regarding the approaches used by Lee et al. and by Heymann and Dziczkaniec make it necessary to restudy the work of Lee et al. Attention is given to the survival probabilities of nuclear species of interest, taking into accounts the elements Cs, Ba, I, and Xe.

  4. Facilitating Change Through a Simplified R and D Process.

    ERIC Educational Resources Information Center

    Osguthorpe, Russell T.; Bishop, Milo E.

    The paper suggests the application of a research and development (R and D) process in an ongoing project at the National Technical Institute for the Deaf. Four phases/stages of the process are discussed: research, development, implementation, and maintenance. It is pointed out that the objective of the project has been to train normal hearing…

  5. The r-process nucleosynthesis: Nuclear physics challenges

    SciTech Connect

    Goriely, S.

    2012-10-20

    About half of the nuclei heavier than iron observed in nature are produced by the socalled rapid neutron capture process, or r-process, of nucleosynthesis. The identification of the astrophysics site and the specific conditions in which the r-process takes place remains, however, one of the still-unsolved mysteries of modern astrophysics. Another underlying difficulty associated with our understanding of the r-process concerns the uncertainties in the predictions of nuclear properties for the few thousands exotic neutron-rich nuclei involved and for which essentially no experimental data exist. The present contribution emphasizes some important future challenges faced by nuclear physics in this problem, particularly in the determination of the nuclear structure properties of exotic neutron-rich nuclei as well as their radiative neutron capture rates and their fission probabilities. These quantities are particularly relevant to determine the composition of the matter resulting from the r-process. Their impact on the r-abundance distribution resulting from the decompression of neutron star matter is discussed.

  6. Use of the median process of the pygophore in the identification of Rhodnius nasutus, R. neglectus, R. prolixus and R. robustus (Hemiptera: Reduviidae).

    PubMed

    Harry, M

    1993-06-01

    The morphometrics of the median process of the male pygophore of four species of blood-sucking bugs (Rhodnius prolixus, R. robustus, R. nasutus and R. neglectus) were compared using one-way analysis of variance. Although there were no significant differences in the pygophoral patterns within the R. nasutus-R. neglectus or R. prolixus-R. robustus species pairs, there were clear-cut differences between them; the median process of R. nasutus-R. neglectus is stout and subtriangular whereas that of R. prolixus-R. robustus is more narrow and elongated. The basal width of the process, classically used to separate R. robustus from R. prolixus and R. nasutus from R. neglectus, seems to have little taxonomic value. Other characters which have been assumed to be species-specific should be subjected to a similar quantitative analysis. PMID:8257239

  7. Rosen’s (M,R) system in process algebra

    PubMed Central

    2013-01-01

    Background Robert Rosen’s Metabolism-Replacement, or (M,R), system can be represented as a compact network structure with a single source and three products derived from that source in three consecutive reactions. (M,R) has been claimed to be non-reducible to its components and algorithmically non-computable, in the sense of not being evaluable as a function by a Turing machine. If (M,R)-like structures are present in real biological networks, this suggests that many biological networks will be non-computable, with implications for those branches of systems biology that rely on in silico modelling for predictive purposes. Results We instantiate (M,R) using the process algebra Bio-PEPA, and discuss the extent to which our model represents a true realization of (M,R). We observe that under some starting conditions and parameter values, stable states can be achieved. Although formal demonstration of algorithmic computability remains elusive for (M,R), we discuss the extent to which our Bio-PEPA representation of (M,R) allows us to sidestep Rosen’s fundamental objections to computational systems biology. Conclusions We argue that the behaviour of (M,R) in Bio-PEPA shows life-like properties. PMID:24237684

  8. r-PROCESS Nucleosynthesis in Proto-Magnetar Winds

    NASA Astrophysics Data System (ADS)

    Thompson, Todd A.

    2004-09-01

    The astrophysical origin of the r-process nuclei is unknown. Because of their association with supernovae and intrinsic neutron-richness, protoneutron star winds are considered as a likely candidate site for production of the r-process nuclei. However, most models of winds from "canonical" neutron stars with mass of 1.4 M⊙ and radius of 10 km fail to generate the heaviest r-process nuclei. In this proceedings we provide a brief review of the protoneutron star wind scenario and discuss the emergence of these outflows in the context of fully dynamical models of successful core-collapse supernovae. That standard models fail motivates an exploration of more extreme neutron star environments. We address some issues surrounding winds from highly magnetic (B0 ≳ 1015 G) protoneutron stars ('proto-magnetars'), including magnetic trapping of wind material and entropy amplification. We further speculate on the role of rapid rotation in this context and the resulting nucleosynthesis.

  9. r-PROCESS Reaction Rates for the Actinides and Beyond

    NASA Astrophysics Data System (ADS)

    Panov, I. V.; Korneev, I. Yu.; Rauscher, T.; Thielemann, F.-K.

    2011-10-01

    We discuss the importance of different fission rates for the formation of heavy and superheavy nuclei in the astrophysical r-process. Neutron-induced reaction rates, including fission and neutron capture, are calculated in the temperature range 108 ≤ T(K) ≤ 1010 within the framework of the statistical model for targets with the atomic number 84 ≤ Z ≤ 118 (from Po to Uuo) from the neutron to the proton drip-line for different mass and fission barrier predictions based on Thomas-Fermi (TF), Extended Thomas-Fermi plus Strutinsky Integral (ETFSI), Finite-Range Droplet Model (FRDM) and Hartree-Fock-Bogolyubov (HFB) approaches. The contribution of spontaneous fission as well as beta-delayed fission to the recycling r-process is discussed. We also discuss the possibility of rate tests, based on mini r-processed yields in nuclear explosions.

  10. Impact of individual nuclear masses on r -process abundances

    NASA Astrophysics Data System (ADS)

    Mumpower, M. R.; Surman, R.; Fang, D.-L.; Beard, M.; Mller, P.; Kawano, T.; Aprahamian, A.

    2015-09-01

    We have performed for the first time a comprehensive study of the sensitivity of r -process nucleosynthesis to individual nuclear masses across the chart of nuclides. Using the latest version (2012) of the Finite-Range Droplet Model, we consider mass variations of 0.5 MeV and propagate each mass change to all affected quantities, including Q values, reaction rates, and branching ratios. We find such mass variations can result in up to an order of magnitude local change in the final abundance pattern produced in an r -process simulation. We identify key nuclei whose masses have a substantial impact on abundance predictions for hot, cold, and neutron star merger r -process scenarios and could be measured at future radioactive beam facilities.

  11. Impact of individual nuclear masses on r-process abundances

    DOE PAGESBeta

    Mumpower, M. R.; Surman, R.; Fang, D. -L.; Beard, M.; Möller, P.; Kawano, T.; Aprahamian, A.

    2015-09-15

    We have performed for the first time a comprehensive study of the sensitivity of r-process nucleosynthesis to individual nuclear masses across the chart of nuclides. Using the latest version (2012) of the Finite-Range Droplet Model, we consider mass variations of ±0.5 MeV and propagate each mass change to all affected quantities, including Q values, reaction rates, and branching ratios. We find such mass variations can result in up to an order of magnitude local change in the final abundance pattern produced in an r-process simulation. As a result, we identify key nuclei whose masses have a substantial impact on abundancemore » predictions for hot, cold, and neutron star merger r-process scenarios and could be measured at future radioactive beam facilities.« less

  12. The r-, s-, and p-Processes in Nucleosynthesis

    NASA Technical Reports Server (NTRS)

    Meyer, Bradley S.

    1994-01-01

    Burbidge et al (1957) and Cameron (1957) laid out the framework for our understanding of the formation of the heavy nuclei (those nuclei with mass number A approx. greater than 70). From systematics in the solar system abundance distribution, Burbidge et al determined that the heavy nuclei were formed in three distinct nucleosynthetic processes, which they termed the r-, s-, and p-processes. That we still use these terms today is a credit to the soundness of this work done 37 years ago. We may understand how Burbidge et al and Cameron arrived at their conclusions from Figure 1. One population of nuclei, the s-nuclei, shows an abundance distribution with peaks near mass numbers 87, 138, and 208. These nuclei are made in a slow neutron-capture process, the s-process. A rapid neutron-capture process, the r-process, is responsible for the r-nuclei, whose abundance distribution shows peaks at mass numbers 80, 130, and 195. The p-process is responsible for production of the rarer, more proton-rich heavy isotopes (the p-nuclei) that cannot be made by neutron capture. The first quantitative evaluations of the ideas of Burbidge et al and Cameron came to light in the early 1960s with work on the s-process (Clayton et al 1961, Seeger et al 1965) and the r-process (Seeger et al 1965). These calculations further elucidated the mechanisms for heavy-element formation and showed the plausibility of the framework developed in the 1950s. Subsequent work has focused on determining the astrophysical sites where the r-, s-, and p-processes occurred with the help of improved nuclear details, stellar models, and abundances. A goal of this paper is to review the recent progress astrophysicists, astronomers, and physicists have made in these directions and to point out the problems that remain in our understanding of the formation of the heavy nuclei. Another, perhaps deeper, goal is to to seek some understanding of why there are three major processes available to nature for synthesis of heavy elements. It is impossible for a single paper to cover all relevant aspects of the r-, s-, and p-processes; therefore, where possible, references to other reviews are given. Readers should turn to these reviews for more details. Nevertheless, it is hoped that the present paper gives some flavor for the rich field of heavy-element synthesis.

  13. Steady flow approximations to the helium r-process

    NASA Technical Reports Server (NTRS)

    Cameron, A. G. W.; Cowan, J. J.; Klapdor, H. V.; Metzinger, J.; Oda, T.; Truran, J. W.

    1983-01-01

    A steady flow approximation to the r-process is presented and used for numerical experiments with physical quantities to determine the sensitivity of the process to variations in those quantities. The effect of neutron capture cross sections along the capture path and of recently available improved beta decay rates on the r-process are discussed. The peaks in the observed r-process yield curve near mass numbers 80 and 130 are roughly characterized by a neutron number density of 10 to the 20th per cu/cm; the mean beta decay rates are about 10/s, and the freezing time is comparable to or less than 0.1 s. The peak near mass number 195 is roughly characterized by a neutron number density of 10 to the 21st/cm, the mean beta decay rates are about 100/s, and the freezing time is comparable to or less than 0.01 s. The flow path of the steady state r-process is sensitively dependent upon the neutron capture cross sections in the flow network and on the values of the beta decay rates.

  14. Global Monte Carlo Calculations for r-process Nucleosynthesis

    NASA Astrophysics Data System (ADS)

    Mumpower, Matthew; Surman, Rebecca; Aprahamian, Ani

    2015-10-01

    The rapid neutron capture process is believed to be responsible for the production of approximately half of the heavy elements above iron on the periodic table. Nuclear physics properties (e.g. nuclear masses, neutron capture rates, β-decay rates, and β-delayed neutron emission branching ratios) are critical inputs that go into theoretical calculations of this nucleosynthesis process. We highlight the current capabilities of nuclear models to reproduce the pattern of solar r-process residuals by performing global Monte Carlo variations of the uncertain nuclear physics inputs. We also explore the reduction in uncertainties that may arise from new measurements or improved modeling and discuss the implications for using abundance pattern details to constrain the site of the r process. This work was supported in part by the National Science Foundation through the Joint Institute for Nuclear Astrophysics Grant Numbers PHY0822648 and PHY1419765, and the Department of Energy under Contracts DE-SC0013039 (RS).

  15. The r-, s-, and p-Processes in Nucleosynthesis

    NASA Technical Reports Server (NTRS)

    Meyer, Bradley S.

    1994-01-01

    A goal of this paper is to review the recent progress astrophysicists, astronomers, and physicists have made in the r-, s-, and p-processes in nucleosynthesis and to point out the problems that remain in our understanding of the formation of the heavy nuclei. Another, perhaps deeper, goal is to to seek some understanding of why there are three major processes available to nature for synthesis of heavy elements.

  16. The r-PROCESS in Core-Collapse Supernovae

    NASA Astrophysics Data System (ADS)

    Wanajo, Shinya; Kajino, Toshitaka; Mathews, Grant J.; Otsuki, Kaori

    We present calculations of r-process nucleosynthesis in neutrino-driven winds from the nascent neutron stars of core-collapse supernovae. A full dynamical reaction network for both the α-rich freezeout and the subsequent r-process is employed. The physical properties of the neutrino-heated ejecta are deduced from a general relativistic model in which spherical symmetry and steady flow are assumed. Our results suggest that proto-neutron stars with a large compaction ratio provide the most robust physical conditions for the r-process. This is due to the short dynamical timescale of material in the wind. Our results have confirmed that the neutrino-driven wind scenario is still a promising site in which to form the solar r-process abundances. However, our best results seem to imply both a rather soft neutron-star equation of state and a massive proto-neutron star which is difficult to achieve with standard core-collapse models. We propose that the most favorable conditions perhaps require that a massive supernova progenitor forms a massive proto-neutron star by accretion after a failed initial neutrino burst.

  17. Extinct Radioactivities and the R-Process Jet

    NASA Technical Reports Server (NTRS)

    Cameron, A. G. W.

    2001-01-01

    All extinct radioactive species in the solar nebula were injected from a core-collapse supernova. I discuss primarily the products expected from an r-process jet in this supernova, and various supporting astrophysical observations. Additional information is contained in the original extended abstract.

  18. The Impact of Fission on R-Process Calculations

    NASA Astrophysics Data System (ADS)

    Eichler, M.; Arcones, A.; Käppeli, R.; Korobkin, O.; Liebendörfer, M.; Martinez-Pinedo, G.; Panov, I. V.; Rauscher, T.; Rosswog, S.; Thielemann, F.-K.; Winteler, C.

    2016-01-01

    We have performed r-process calculations in neutron star mergers (NSM) and jets of magnetohydrodynamically driven (MHD) supernovae. In these very neutron-rich environments the fission model of heavy nuclei has an impact on the shape of the final abundance distribution and the second r-process peak in particular. We have studied the effect of different fission fragment mass distribution models in calculations of low-Ye ejecta, ranging from a simple parametrization to extensive statistical treatments (ABLA07). The r-process path ends when it reaches an area in the nuclear chart where fission dominates over further neutron captures. The position of this point is determined by the fission barriers and the neutron separation energies of the nuclei involved. As these values both depend on the choice of the nuclear mass model, so does the r-process path. Here we present calculations using the FRDM (Finite Range Droplet Model) and the ETFSI (Extended Thomas Fermi with Strutinsky Integral) mass model with the related TF and ETFSI fission barrier predictions. Utilizing sophisticated fission fragment distribution leads to a highly improved abundance distribution.

  19. β-decay spectroscopy for the r-process nucleosynthesis

    SciTech Connect

    Nishimura, Shunji; Collaboration: RIBF Decay Collaborations

    2014-05-09

    Series of decay spectroscopy experiments, utilizing of high-purity Ge detectors and double-sided silicon-strip detectors, have been conducted to harvest the decay properties of very exotic nuclei relevant to the r-process nucleosynthesis at the RIBF. The decay properties such as β-decay half-lives, low-lying states, β-delayed neutron emissions, isomeric states, and possibly Q{sub β} of the very neutron-rich nuclei are to be measured to give significant constraints in the uncertainties of nuclear properties for the r-process nucleosynthesis. Recent results of βγ spectroscopy study using in-flight fission of {sup 238}U-beam will be presented together with our future perspectives.

  20. Neutron tori and the origin of r-process elements

    NASA Technical Reports Server (NTRS)

    Hogan, C. J.; Applegate, J. H.

    1987-01-01

    It is shown here that if an accretion disk gets hotter than a few MeV, nuclei in the infalling matter are dissociated into their constituent neutrons and protons. Neutrons released by dissociation of matter falling at high accretion rates into a black hole or neutron star accumulate in a dense 'neutron torus'. The occurrence of the classical rapid or r-process nucleosynthesis in such a torus is investigated.

  1. Space - A unique environment for process modeling R&D

    NASA Technical Reports Server (NTRS)

    Overfelt, Tony

    1991-01-01

    Process modeling, the application of advanced computational techniques to simulate real processes as they occur in regular use, e.g., welding, casting and semiconductor crystal growth, is discussed. Using the low-gravity environment of space will accelerate the technical validation of the procedures and enable extremely accurate determinations of the many necessary thermophysical properties. Attention is given to NASA's centers for the commercial development of space; joint ventures of universities, industries, and goverment agencies to study the unique attributes of space that offer potential for applied R&D and eventual commercial exploitation.

  2. The r-Process and Neutrino-Powered Winds

    NASA Astrophysics Data System (ADS)

    Hoffman, R. D.; Woosley, S. E.; Matthews, G.; Wilson, J. R.; Meyer, B. S.

    1993-05-01

    During iron core collapse and subsequent neutron star formation in massive stars, ~ 10% of the binding energy of the neutron star is released during a Kelvin-Helmholtz time scale in the form of neutrinos whose energy is deposited within an atmosphere in near hydrostatic equilibrium, giving rise to a ``neutrino-driven wind''. This wind is powered by neutrino/antineutrino capture on nucleons which, due to to hardening of the antineutrino spectrum at late times, causes the material to become neutron-rich. Additionally, due to the short pressure scale height, the region will have a high entropy (30 <= S/N_Ak <= 450). These conditions conspire to form a region that is especially well suited to the production of the r-process. We present calculations that study the detailed nucleosynthesis that occurs within the last 0.02 M_⊙ of material ejected in the delayed explosion of a 20 M_⊙ Type II supernova model. The thermal and compositional evolution of a large number of sample trajectories (40 choices of rho (t), T(t), Y_e(t)) that decrease smoothly and logarithmically down to 10(-6) M_⊙ are followed for times as late as 15 seconds after core collapse. We find that a large number of isotopes from mass A ~ 60 to 200 are produced in quantities of interest to galactic chemical evolution. Unfortunately, the model does not give a satisfactory r-process. The two basic problems are too much material having entropy ~ 40 and Y_e <= 0.47 which comprises much of the ejecta at times in the evolution of the wind before the conditions for the r-process are acheived. These conditions consipre to overproduce nuclei in the N=50 closed neutron shell to such a degree that the star is incapable of producing even oxygen. Additionally, the entropy at late times needs to be ~ 50% larger to produce the heaviest r-process isotopes. In an acceptable model the entropy would be lower at early times when the mass loss rate is large and higher at late times when the mass loss rate is small. Reasons for why this might actually occur in nature are discussed. Despite the current difficulties found in this particular model, neutrino powered winds from nascent neutron stars remain very attractive sites for the r-process.

  3. Novel technique for Constraining r -Process (n , γ ) Reaction Rates

    NASA Astrophysics Data System (ADS)

    Spyrou, A.; Liddick, S. N.; Larsen, A. C.; Guttormsen, M.; Cooper, K.; Dombos, A. C.; Morrissey, D. J.; Naqvi, F.; Perdikakis, G.; Quinn, S. J.; Renstrøm, T.; Rodriguez, J. A.; Simon, A.; Sumithrarachchi, C. S.; Zegers, R. G. T.

    2014-12-01

    A novel technique has been developed, which will open exciting new opportunities for studying the very neutron-rich nuclei involved in the r process. As a proof of principle, the γ spectra from the β decay of 76Ga have been measured with the SuN detector at the National Superconducting Cyclotron Laboratory. The nuclear level density and γ -ray strength function are extracted and used as input to Hauser-Feshbach calculations. The present technique is shown to strongly constrain the 75Ge (n ,γ )76Ge cross section and reaction rate.

  4. Probabilities of delayed processes for nuclei involved in the r-process

    SciTech Connect

    Panov, I. V.; Korneev, I. Yu.; Lutostansky, Yu. S.; Thielemann, F.-K.

    2013-01-15

    Delayed fission, along with induced and spontaneous fission, is responsible for the suppression of the production of superheavy elements both during the r-process and after its completion. Beta-decay strength functions are required for calculating delayed fission. In the present study, respective strength functions are calculated by relying on the theory of finite Fermi systems and by predominantly employing nuclear masses and fission barriers predicted by a generalized Thomas-Fermi model. The probabilities for delayed fission and for the emission of delayed neutrons are calculated for a number of isotopes. On the basis of calculations performed in order to determine the probabilities for delayed processes, it is shown that some of the delayed-fission probabilities calculated thus far were substantially overestimated. The application of these new results to calculating the r-process may change substantially both the r-process path and the yields of superheavy nuclei.

  5. MODISTools - downloading and processing MODIS remotely sensed data in R.

    PubMed

    Tuck, Sean L; Phillips, Helen Rp; Hintzen, Rogier E; Scharlemann, Jrn Pw; Purvis, Andy; Hudson, Lawrence N

    2014-12-01

    Remotely sensed data - available at medium to high resolution across global spatial and temporal scales - are a valuable resource for ecologists. In particular, products from NASA's MODerate-resolution Imaging Spectroradiometer (MODIS), providing twice-daily global coverage, have been widely used for ecological applications. We present MODISTools, an R package designed to improve the accessing, downloading, and processing of remotely sensed MODIS data. MODISTools automates the process of data downloading and processing from any number of locations, time periods, and MODIS products. This automation reduces the risk of human error, and the researcher effort required compared to manual per-location downloads. The package will be particularly useful for ecological studies that include multiple sites, such as meta-analyses, observation networks, and globally distributed experiments. We give examples of the simple, reproducible workflow that MODISTools provides and of the checks that are carried out in the process. The end product is in a format that is amenable to statistical modeling. We analyzed the relationship between species richness across multiple higher taxa observed at 526 sites in temperate forests and vegetation indices, measures of aboveground net primary productivity. We downloaded MODIS derived vegetation index time series for each location where the species richness had been sampled, and summarized the data into three measures: maximum time-series value, temporal mean, and temporal variability. On average, species richness covaried positively with our vegetation index measures. Different higher taxa show different positive relationships with vegetation indices. Models had high R (2) values, suggesting higher taxon identity and a gradient of vegetation index together explain most of the variation in species richness in our data. MODISTools can be used on Windows, Mac, and Linux platforms, and is available from CRAN and GitHub (https://github.com/seantuck12/MODISTools). PMID:25558360

  6. r-process kilonova emission accompanying short-duration GRBs

    NASA Astrophysics Data System (ADS)

    Tanvir, Nial

    2014-10-01

    Our recent HST observations of the short-duration GRB130603B showed an infrared excess, about ten days after the burst, consistent with expectations from models of an emerging 'kilonova' driven by the radioactive decay of newly-synthesised r-process elements. This directly supports the compact object merger hypothesis for short-duration GRBs, in which ejected neutron star material powers a radioactive transient. The discovery also provides a new, quasi-isotropic, electromagnetic localisation signature of the most promising class of gravitational wave (GW) sources for detection with the next generation of detectors, and suggests that kilonovae of this sort are likely sites of substantial (perhaps dominant) production of r-process elements in the universe. However, the ubiquity and range of behaviour of these events is entirely unknown. We need to establish their properties to inform searches of GW error boxes and quantify their contribution to the heavy element nucleosynthesis budget. Here we propose ToO observations a low-redshift (z<~0.35) SGRB localised during cycle 22 to search for and characterise more fully any similar kilonova signal.

  7. R-Process Ejecta in the VELA Supernova Remnant

    NASA Astrophysics Data System (ADS)

    Wallerstein, George

    1990-12-01

    Groundbased, X-ray and radio studies reveal many properties of supernovae but none except for the neutrinos from SN1987A have been able to tell us anything about the mechanism of the explosion. By looking for r-process and heavy iron-peak isotopes we can estimate the amount of neutronized material ejected and hence get a grip on what actually happened during the explosion. We will search for interstellar absorption lines of KrI, HgII, Os II, W II, and Pt II in stars within and behind the Vela supernova remnant. Substantial quantities of these elements are expected to be ejected in supernova explosions. However, recent competing theories of the supernova explosion mechanism predict differing amounts of r-process ejecta and in this way our observation will provide important constraints on these models. This will be a direct observational input on the supernova mechanism, a theoretical problem on which much time, effort, and manpower have been expended.

  8. The r-process and neutrino-heated supernova ejecta

    NASA Technical Reports Server (NTRS)

    Woosley, S. E.; Wilson, J. R.; Mathews, G. J.; Hoffman, R. D.; Meyer, B. S.

    1994-01-01

    As a neutron star is formed by the collapse of the iron core of a massive star, its Kelvin-Helmholtz evolution is characterized by the release of gravitational binding energy as neutrinos. The interaction of these neutrinos with heated material above the neutron star generates a hot bubble in an atmosphere that is nearly in hydrostatic equilibrium and heated, after approximately 10 s, to an entropy of S/N(sub AS)k greater than or approximately = 400. The neutron-to-proton ratio for material moving outward through this bubble is set by the balance between neutrino and antineutrino capture on nucleons. Because the electron antineutrino spectrum at this time is hotter than the electron neutrino spectrum, the bubble is neutron-rich (0.38 less than or approximately = Y(sub e) less than or approximately = 0.47). Previous work using a schematic model has shown that these conditions are well suited to the production of heavy elements by the r-process. In this paper we have advanced the numerical modeling of a 20 solar mass 'delayed' supernova explosion to the point that we can follow the detailed evolution of material moving through the bubble at the late times appropiate to r-process nucleosynthesis. The supernova model predicts a final kinetic energy for the ejecta of 1.5 x 10(exp 51) ergs and leaves behind a remnant with a baryon mass of 1.50 solar mass (and a gravitational mass of 1.445 solar mass). We follow the thermodynamic and compositional evolution of 40 trajectories in rho(t), T(t), Y(sub e)(t) for a logarithmic grid of mass elements for the last approximately = 0.03 solar mass to be ejected by the proto-neutron star down to the last less than 10(exp -6) solar mass of material expelled at up to approximately = 18 s after core collapse. We find that an excellent fit to the solar r-process abundance distribution is obtained with no adjustable parameters in the nucleosynthesis calculations. Moreover, the abundances are produced in the quantities required to account for the present Galactic abundances. However, at earlier times, this one-dimensional model ejects too much material with entropies S/N(sub A)k approximately 50 and Y(sub e) approximately 0.46. This leads to an acceptable over production of N = 50 nuclei, particularly Sr-88, Y-89, and Zr-90, relative to their solar abundances. We speculate on various means to avoid the early overproduction and/or ejection of N = 50 isotonic nuclei while still producing and ejecting the correct amount of r-process material.

  9. r-process Lanthanide Production and Heating Rates in Kilonovae

    NASA Astrophysics Data System (ADS)

    Lippuner, Jonas; Roberts, Luke F.

    2015-12-01

    r-process nucleosynthesis in material ejected during neutron star mergers may lead to radioactively powered transients called kilonovae. The timescale and peak luminosity of these transients depend on the composition of the ejecta, which determines the local heating rate from nuclear decays and the opacity. Kasen et al. and Tanaka & Hotokezaka pointed out that lanthanides can drastically increase the opacity in these outflows. We use the new general-purpose nuclear reaction network SkyNet to carry out a parameter study of r-process nucleosynthesis for a range of initial electron fractions Ye, initial specific entropies s, and expansion timescales τ. We find that the ejecta is lanthanide-free for Ye ≳ 0.22-0.30, depending on s and τ. The heating rate is insensitive to s and τ, but certain, larger values of Ye lead to reduced heating rates, due to individual nuclides dominating the heating. We calculate approximate light curves with a simplified gray radiative transport scheme. The light curves peak at about a day (week) in the lanthanide-free (-rich) cases. The heating rate does not change much as the ejecta becomes lanthanide-free with increasing Ye, but the light-curve peak becomes about an order of magnitude brighter because it peaks much earlier when the heating rate is larger. We also provide parametric fits for the heating rates between 0.1 and 100 days, and we provide a simple fit in Ye, s, and τ to estimate whether or not the ejecta is lanthanide-rich.

  10. Assessment of advanced coal-gasification processes. [AVCO high throughput gasification in process; Bell High Mass Flux process; CS-R process; and Exxon Gasification process

    SciTech Connect

    McCarthy, J.; Ferrall, J.; Charng, T.; Houseman, J.

    1981-06-01

    This report represents a technical assessment of the following advanced coal gasification processes: AVCO High Throughput Gasification (HTG) Process, Bell Single - Stage High Mass Flux (HMF) Process, Cities Service/Rockwell (CS/R) Hydrogasification Process, and the Exxon Catalytic Coal Gasification (CCG) Process. Each process is evaluated for its potential to produce SNG from a bituminous coal. In addition to identifying the new technology these processes represent, key similarities/differences, strengths/weaknesses, and potential improvements to each process are identified. The AVCO HTG and the Bell HMF gasifiers share similarities with respect to: short residence time (SRT), high throughput rate, slagging and syngas as the initial raw product gas. The CS/R Hydrogasifier is also SRT but is non-slagging and produces a raw gas high in methane content. The Exxon CCG gasifier is a long residence time, catalytic fluidbed reactor producing all of the raw product methane in the gasifier.

  11. Nucleon-Alpha Particle Disequilibrium and Short-Lived r-Process Radioactivities

    NASA Technical Reports Server (NTRS)

    Meyer, B. S.; Clayton, D. D.; Chellapilla, S.; The, L.-S.

    2002-01-01

    r-Process yields can be extremely sensitive to expansion parameters when a persistent disequilibrium between free nucleons and alpha particles is present. This may provide a natural scenario for understanding the variation of heavy and light r-process isotopes in different r-process events. Additional information is contained in the original extended abstract.

  12. Nucleon-Alpha Particle Disequilibrium and Short-Lived r-Process Radioactivities

    NASA Astrophysics Data System (ADS)

    Meyer, B. S.; Clayton, D. D.; Chellapilla, S.; The, L.-S.

    2002-03-01

    r-Process yields can be extremely sensitive to expansion parameters when a persistent disequilibrium between free nucleons and alpha particles is present. This may provide a natural scenario for understanding the variation of heavy and light r-process isotopes in different r-process events.

  13. THE r-PROCESS IN METAL-POOR STARS AND BLACK HOLE FORMATION

    SciTech Connect

    Boyd, R. N.; Famiano, M. A.; Meyer, B. S.; Motizuki, Y.; Kajino, T.; Roederer, I. U.

    2012-01-15

    Nucleosynthesis of heavy nuclei in metal-poor stars is generally thought to occur via the r-process because the r-process is a primary process that would have operated early in the Galaxy's history. This idea is strongly supported by the fact that the abundance pattern in many metal-poor stars matches well the inferred solar r-process abundance pattern in the mass range between the second and third r-process abundance peaks. Nevertheless, a significant number of metal-poor stars do not share this standard r-process template. In this Letter, we suggest that the nuclides observed in many of these stars are produced by the r-process, but that it is prevented from running to completion in more massive stars by collapse to black holes before the r-process is completed, creating a 'truncated r-process', or 'tr-process'. We find that the observed fraction of tr-process stars is qualitatively what one would expect from the initial mass function and that an apparent sharp truncation observed at around mass 160 could result from a combination of collapses to black holes and the difficulty of observing the higher mass rare-earth elements. We test the tr-process hypothesis with r-process calculations that are terminated before all r-process trajectories have been ejected. We find qualitative agreement between observation and theory when black hole collapse and observational realities are taken into account.

  14. Helping science to succeed: improving processes in R&D.

    PubMed

    Sewing, Andreas; Winchester, Toby; Carnell, Pauline; Hampton, David; Keighley, Wilma

    2008-03-01

    Bringing drugs to the market remains a costly and, until now, often unpredictable challenge. Although understanding the underlying science is key to further progress, our imperfect knowledge of disease and complex biological systems leaves excellence in execution as the most tangible lever to sustain our serendipitous approach to drug discovery. The problems encountered in pharmaceutical R&D are not unique, but to learn from other industries it is important to recognise similarity, rather than differences, and to advance industrialisation of R&D beyond technology and automation. Tools like Lean and Six Sigma, already applied to increase business excellence across diverse organisations, can equally be introduced to pharmaceutical R&D and offer the potential to transform operations without large-scale investment. PMID:18342798

  15. The impact of global nuclear mass model uncertainties on r-process abundance predictions

    NASA Astrophysics Data System (ADS)

    Mumpower, M.; Surman, R.; Aprahamian, A.

    2015-05-01

    Rapid neutron capture or `r-process' nucleosynthesis may be responsible for half the production of heavy elements above iron on the periodic table. Masses are one of the most important nuclear physics ingredients that go into calculations of r-process nucleosynthesis as they enter into the calculations of reaction rates, decay rates, branching ratios and Q-values. We explore the impact of uncertainties in three nuclear mass models on r-process abundances by performing global monte carlo simulations. We show that root-mean-square (rms) errors of current mass models are large so that current r-process predictions are insufficient in predicting features found in solar residuals and in r-process enhanced metal poor stars. We conclude that the reduction of global rms errors below 100 keV will allow for more robust r-process predictions.

  16. Standardization of the WISC-R in Puerto Rico: The Process and the Preliminary Findings.

    ERIC Educational Resources Information Center

    Herrans, Laura L.; And Others

    The process of adapting the Wechsler Intelligence Scale for Children-Revised (WISC-R) for Puerto Rico was begun with the following objectives: (1) to review the existing Spanish translation of the WISC-R; (2) to adapt the WISC-R to Puerto Rican culture and milieu; and (3) to standardize the scale with a representative sample of Puerto Rican…

  17. R-process enrichment from a single event in an ancient dwarf galaxy.

    PubMed

    Ji, Alexander P; Frebel, Anna; Chiti, Anirudh; Simon, Joshua D

    2016-03-31

    Elements heavier than zinc are synthesized through the rapid (r) and slow (s) neutron-capture processes. The main site of production of the r-process elements (such as europium) has been debated for nearly 60 years. Initial studies of trends in chemical abundances in old Milky Way halo stars suggested that these elements are produced continually, in sites such as core-collapse supernovae. But evidence from the local Universe favours the idea that r-process production occurs mainly during rare events, such as neutron star mergers. The appearance of a plateau of europium abundance in some dwarf spheroidal galaxies has been suggested as evidence for rare r-process enrichment in the early Universe, but only under the assumption that no gas accretes into those dwarf galaxies; gas accretion favours continual r-process enrichment in these systems. Furthermore, the universal r-process pattern has not been cleanly identified in dwarf spheroidals. The smaller, chemically simpler, and more ancient ultrafaint dwarf galaxies assembled shortly after the first stars formed, and are ideal systems with which to study nucleosynthesis events such as the r-process. Reticulum II is one such galaxy. The abundances of non-neutron-capture elements in this galaxy (and others like it) are similar to those in other old stars. Here, we report that seven of the nine brightest stars in Reticulum II, observed with high-resolution spectroscopy, show strong enhancements in heavy neutron-capture elements, with abundances that follow the universal r-process pattern beyond barium. The enhancement seen in this 'r-process galaxy' is two to three orders of magnitude higher than that detected in any other ultrafaint dwarf galaxy. This implies that a single, rare event produced the r-process material in Reticulum II. The r-process yield and event rate are incompatible with the source being ordinary core-collapse supernovae, but consistent with other possible sources, such as neutron star mergers. PMID:27001693

  18. R-process enrichment from a single event in an ancient dwarf galaxy

    NASA Astrophysics Data System (ADS)

    Ji, Alexander P.; Frebel, Anna; Chiti, Anirudh; Simon, Joshua D.

    2016-03-01

    Elements heavier than zinc are synthesized through the rapid (r) and slow (s) neutron-capture processes. The main site of production of the r-process elements (such as europium) has been debated for nearly 60 years. Initial studies of trends in chemical abundances in old Milky Way halo stars suggested that these elements are produced continually, in sites such as core-collapse supernovae. But evidence from the local Universe favours the idea that r-process production occurs mainly during rare events, such as neutron star mergers. The appearance of a plateau of europium abundance in some dwarf spheroidal galaxies has been suggested as evidence for rare r-process enrichment in the early Universe, but only under the assumption that no gas accretes into those dwarf galaxies; gas accretion favours continual r-process enrichment in these systems. Furthermore, the universal r-process pattern has not been cleanly identified in dwarf spheroidals. The smaller, chemically simpler, and more ancient ultrafaint dwarf galaxies assembled shortly after the first stars formed, and are ideal systems with which to study nucleosynthesis events such as the r-process. Reticulum II is one such galaxy. The abundances of non-neutron-capture elements in this galaxy (and others like it) are similar to those in other old stars. Here, we report that seven of the nine brightest stars in Reticulum II, observed with high-resolution spectroscopy, show strong enhancements in heavy neutron-capture elements, with abundances that follow the universal r-process pattern beyond barium. The enhancement seen in this ‘r-process galaxy’ is two to three orders of magnitude higher than that detected in any other ultrafaint dwarf galaxy. This implies that a single, rare event produced the r-process material in Reticulum II. The r-process yield and event rate are incompatible with the source being ordinary core-collapse supernovae, but consistent with other possible sources, such as neutron star mergers.

  19. Realistic fission model and the r-process in neutron star mergers

    SciTech Connect

    Shibagaki, S.; Kajino, T.; Chiba, S.; Mathews, G. J.

    2014-05-09

    About half of heavy elements are considered to be produced by the rapid neutron-capture process, r-process. The neutron star merger is one of the viable candidates for the astrophysical site of r-process nucleosynthesis. Nuclear fission reactions play an important role in the r-process of neutron star mergers. However theoretical predictions about fission properties of neutron-rich nuclei have some uncertainties. Especially, their fission fragment distributions are totally unknown and the phenomenologically extrapolated distribution was often applied to nucleosynthesis calculations. In this study, we have carried out r-process nucleosynthesis calculations based upon new theoretical estimates of fission fragment distributions. We discuss the effects on the r-process in neutron star mergers from the nuclear fission of heavy neutron-rich actinide elements. We also discuss how variations in the fission fragment distributions affect the abundance pattern.

  20. Solid-State Lighting: Cantilever Epitaxy Process Wins R&D 100 Award

    SciTech Connect

    2012-04-19

    Sandia National Laboratories received an R&D 100 Award from R&D Magazine for development of a new process for growing gallium nitride on an etched sapphire substrate. The process, called cantilever epitaxy, promises to make brighter and more efficient green, blue, and white LEDs.

  1. Advanced processing of the Zerodur R glass ceramic

    NASA Astrophysics Data System (ADS)

    Marx, Thomas A.

    1991-11-01

    The Zerodur glass ceramic is an extraordinary material possessing a very low thermal expansion over a broad temperature range. Depending on the size of the castings, a continuous or a discontinuous melting technology is used in the manufacture of Zerodur. Continuous melters are being operated regularly in Germany and recently in the United States. The latest generation of discontinuous melters started production of 8.2 m spincast telescope blanks in early 1991. Zerodur fusion is a special process to generate lightweighted mirror blanks and special components. It requires glassy material and generates bonds that are as strong as the bulk material. Further process development such as waterjet cutting and insertion technologies are underway and may generate components of unique shapes and performance.

  2. DETECTION OF THE SECOND r-PROCESS PEAK ELEMENT TELLURIUM IN METAL-POOR STARS ,

    SciTech Connect

    Roederer, Ian U.; Lawler, James E.; Cowan, John J.; Beers, Timothy C.; Frebel, Anna; Ivans, Inese I.; Schatz, Hendrik; Sobeck, Jennifer S.; Sneden, Christopher

    2012-03-15

    Using near-ultraviolet spectra obtained with the Space Telescope Imaging Spectrograph on board the Hubble Space Telescope, we detect neutral tellurium in three metal-poor stars enriched by products of r-process nucleosynthesis, BD +17 3248, HD 108317, and HD 128279. Tellurium (Te, Z = 52) is found at the second r-process peak (A Almost-Equal-To 130) associated with the N = 82 neutron shell closure, and it has not been detected previously in Galactic halo stars. The derived tellurium abundances match the scaled solar system r-process distribution within the uncertainties, confirming the predicted second peak r-process residuals. These results suggest that tellurium is predominantly produced in the main component of the r-process, along with the rare earth elements.

  3. r-Process Nucleosynthesis in Black Hole-Neutron Star Mergers

    SciTech Connect

    Surman, Rebecca; Mclaughlin, Gail C; Ruffert, Maximilian; Janka, Hans-Thomas; Hix, William Raphael

    2008-01-01

    Compact object mergers have long been speculated to be a possible site of r-process nucleosynthesis. While most attention has been focused on the cold decompression of neutron star matter ejected from the merger, other sites within the merger likely contribute to its nucleosynthetic output. Here we consider hot outflows from the accretion disk that forms around the black hole following a black hole- neutron star merger. We begin with the results of a three-dimensional numerical merger model and carefully calculate the neutrino and antineutrino fluxes emitted from the accretion disk. We find that neutrino interactions on free nucleons in the outflowing material result in neutron excesses such that at least a weak r-process is produced and in some cases a main r-process as well. Additionally, we find that the weak r-process pattern calculated for certain trajectories compares favorably to the pattern observed in a weak r-process-enhanced halo star.

  4. Decay of the r-PROCESS Nuclides 137,138,139Sb and the A=130 Solar r-PROCESS Abundance Peak

    NASA Astrophysics Data System (ADS)

    Arndt, O.; Kratz, K.-L.; Farouqi, K.; Pfeiffer, B.; Hennrich, S.; Jost, C. J.; Walters, W. B.; Stoyer, M. A.; Köster, U.; Fedosseev, V. N.; Hecht, A. A.; Shergur, J.; Hoteling, N.; Wöhr, A.

    2013-03-01

    Half-life and β-delayed neutron branching values of 492(25) ms and 49(8)%, 350(15) ms and 72(8)%, and 93(13) ms and 90(10)% for the r-process nuclei 137,138,139Sb, respectively, have been measured at CERN/ISOLDE by simultaneously counting β particles and β-delayed neutrons. The sources were prepared by using the selective ionization of Sb with the Resonance Ionization Laser Ion Source and the High-Resolution Mass Separator. These new half-lives and β-delayed neutron branching values are compared with calculated values for both spherical and deformed shapes. The data have been incorporated into parameterized nucleosynthesis calculations of the r-process in high-entropy winds of core-collapse supernovae in order to study the properties of the A=130 Solar-System r-process abundance peak.

  5. New developments in understanding the r-process from observations of metal-poor stars

    NASA Astrophysics Data System (ADS)

    Frebel, Anna

    2015-04-01

    In their atmospheres, old metal-poor Galactic stars retain detailed information about the chemical composition of the interstellar medium at the time of their birth. Extracting such stellar abundances enables us to reconstruct the beginning of the chemical evolution shortly after the Big Bang. About 5% of metal-poor stars with [Fe/H] < - 2 . 5 display in their spectrum a strong enhancement of neutron-capture elements associated with the rapid (r-) nucleosynthesis process that is responsible for the production of the heaviest elements in the Universe. This fortuity provides a unique opportunity of bringing together astrophysics and nuclear physics because these objects act as ``cosmic lab'' for both fields of study. The so-called r-process stars are thought to have formed from material enriched in heavy neutron-capture elements that were created during an r-process event in a previous generation supernova. It appears that the few stars known with this rare chemical signature all follow the scaled solar r-process pattern (for the heaviest elements with 56 <= Z <= 90 that is). This suggests that the r-process is universal - a surprising empirical finding and a solid result that can not be obtained from any laboratory on earth. While much research has been devoted to establishing this pattern, little attention has been given to the overall level of enhancement. New results will be presented on the full extent of r-process element enrichment as observed in metal-poor stars. The challenge lies in determining how the r-process material in the earliest gas clouds was mixed and diluted. Assuming individual r-process events to have contributed the observed r-process elements. We provide empirical estimates on the amount of r-process material produced. This should become a crucial constraint for theoretical nuclear physics models of heavy element nucleosynthesis.

  6. Processing of R-Ba-Cu-O superconductors

    SciTech Connect

    Wu, H.

    1998-02-23

    Precipitation processes were developed to introduce second phases as flux pinning centers in Gd-Ba-Cu-O and Nd-Ba-Cu-O superconductors. In Gd-Ba-Cu-O, precipitation is caused by the decrease of the upper solubility limit of Gd{sub 1+x}Ba{sub 2{minus}x}Cu{sub 3}O{sub 7} solid solution (Gd123ss) in low oxygen partial pressure. Processing of supersaturated Gd{sub 1.2}Ba{sub 1.8}Cu{sub 3}O{sub 7} in low oxygen partial pressure can produce dispersed second phases. Gd211 is formed as a separate phase while extensive Gd124 type stacking fault is formed instead of a separate CuO phase. As a result of the precipitation reaction, the transition temperature and critical current density are increased. In Nd-Ba-Cu-O, precipitation is caused by the decrease of the lower solubility limit of Nd{sub 1+x}Ba{sub 2{minus}x}Cu{sub 3}O{sub 7} solid solution (Nd123ss) in oxygen. DTA results reveal the relative stability of Nd123ss in different oxygen partial pressures. In 1 bar oxygen partial pressure, Nd123ss with x = 0.1 is the most stable phase. In lower oxygen partial pressures, the most stable composition shifts towards the stoichiometric composition. The relative stability changes faster with decreasing oxygen partial pressure. Therefore, processing in oxygen and air tends to produce broad superconducting transitions but sharp transitions can be achieved in 0.01 bar and 0.001 bar oxygen partial pressures. While the lower solubility limits in 0.01 bar and 0.001 bar oxygen partial pressures remain at x = 0.00, the solubility limits in oxygen and air show a narrowing with decreasing temperature. Because of the narrowing of the solubility range in oxygen, oxygen annealing of Nd123 initially processed in low oxygen partial pressures will result in precipitation of second phases. The equilibrium second phase is BaCuO{sub 2} for temperature above 608 C, and at lower temperatures the equilibrium second phases are Ba{sub 2}CuO{sub 3.3} and Ba{sub 2}Cu{sub 3}O{sub 5+y}. However, annealing at low temperature may produce a fine metastable transition phase. A coherent intermediate perovskite structure with a composition of BaCuO{sub 2} is observed along with a high density of dislocations during the precipitation process at 500 C in oxygen. It is believed that oxygen annealing at 900 C produces the equilibrium BaCuO{sub 2} phase. These precipitates are responsible for the strong flux pinning in Nd123 melt-textured in low oxygen partial pressure.

  7. Sensitivity studies for the main r process: β-decay rates

    SciTech Connect

    Mumpower, M.; Cass, J.; Passucci, G.; Aprahamian, A.; Surman, R.

    2014-04-15

    The pattern of isotopic abundances produced in rapid neutron capture, or r-process, nucleosynthesis is sensitive to the nuclear physics properties of thousands of unstable neutron-rich nuclear species that participate in the process. It has long been recognized that the some of the most influential pieces of nuclear data for r-process simulations are β-decay lifetimes. In light of experimental advances that have pushed measurement capabilities closer to the classic r-process path, we revisit the role of individual β-decay rates in the r process. We perform β-decay rate sensitivity studies for a main (A > 120) r process in a range of potential astrophysical scenarios. We study the influence of individual rates during (n, γ)-(γ, n) equilibrium and during the post-equilibrium phase where material moves back toward stability. We confirm the widely accepted view that the most important lifetimes are those of nuclei along the r-process path for each astrophysical scenario considered. However, we find in addition that individual β-decay rates continue to shape the final abundance pattern through the post-equilibrium phase, for as long as neutron capture competes with β decay. Many of the lifetimes important for this phase of the r process are within current or near future experimental reach.

  8. NUCLEAR PHYSICS: Challenge on the Astrophysical R-Process Calculation with Nuclear Mass Models

    NASA Astrophysics Data System (ADS)

    Sun, Bao-Hua; Meng, Jie

    2008-07-01

    Our understanding of the rapid neutron capture nucleosynthesis process in universe depends on the reliability of nuclear mass predictions. Initiated by the newly developed mass table in the relativistic mean field theory (RMF), we investigate the influence of mass models on the r-process calculations, assuming the same astrophysical conditions. The different model predictions on the so far unreachable nuclei lead to significant deviations in the calculated r-process abundances.

  9. The r-Process in Metal Poor Stars and Black Hole Formation

    SciTech Connect

    Boyd, R N; Famiano, M A; Meyer, B S; Motizuki, Y; Kajino, T; Roederer, I U

    2011-11-30

    Nucleosynthesis of heavy nuclei in metal-poor stars is generally ascribed to the r-process, as the abundance pattern in many such stars agrees with the inferred Solar r-process abundances. Nonetheless, a significant number of these stars do not share this r-process template. they suggest that many such stars have begun an r-process, but it was prevented from running to completion in more massive stars by collapse to black holes, creating a 'truncated r-process,' or 'tr-process'. The observed fraction of tr-process stars is found to be consistent with expectations from the initial mass function (IMF), and they suggest that an apparent sharp truncation observed at around mass 160 could result from a combination of collapses to black holes and the difficulty of observing the higher mass rare earths. They test the tr-process hypothesis with calculations that are terminated before all r-process trajectories have been ejected. These produce qualitative agreement with observation when both black hole collapse and observational realities are taken into account.

  10. Chemical compositions of neutron-process elements in low-metallicity stars - tracers of r and r+s nucleosynthesis processes .

    NASA Astrophysics Data System (ADS)

    Ivans, I. I.; Bisterzo, S.; Gallino, R.

    Employing spectra obtained with the near-UV sensitive detector on the Keck I HIRES, comprehensive chemical composition analyses have been performed on the neutron-capture-element-rich star, HD221170 ([Fe/H] = -2.2; Ivans et al 2006), and the binary blue metal-poor star, BPS CS29497-030 (-2.6; Ivans et al. 2005). The heavy element abundances of HD221170 are fit exquisitely well by a scaled-solar r-process abundance pattern with no contribution from the s-process. In contrast, the abundance pattern of CS29497-030 seems best fit by an AGB model with s-processing that also includes very significant amounts of pre-enrichment of r-process material in the protostellar cloud out of which the binary system formed.

  11. Relative Contributions of the Weak, Main, and Fission-recycling r-process

    NASA Astrophysics Data System (ADS)

    Shibagaki, S.; Kajino, T.; Mathews, G. J.; Chiba, S.; Nishimura, S.; Lorusso, G.

    2016-01-01

    There has been a persistent conundrum in attempts to model the nucleosynthesis of heavy elements by rapid neutron capture (the r-process). Although the locations of the abundance peaks near nuclear mass numbers 130 and 195 identify an environment of rapid neutron capture near closed nuclear shells, the abundances of elements just above and below those peaks are often underproduced by more than an order of magnitude in model calculations. At the same time, there is a debate in the literature as to what degree the r-process elements are produced in supernovae or the mergers of binary neutron stars. In this paper we propose a novel solution to both problems. We demonstrate that the underproduction of nuclides above and below the r-process peaks in main or weak r-process models (like magnetohydrodynamic jets or neutrino-driven winds in core-collapse supernovae) can be supplemented via fission fragment distributions from the recycling of material in a neutron-rich environment such as that encountered in neutron star mergers (NSMs). In this paradigm, the abundance peaks themselves are well reproduced by a moderately neutron-rich, main r-process environment such as that encountered in the magnetohydrodynamical jets in supernovae supplemented with a high-entropy, weakly neutron-rich environment such as that encountered in the neutrino-driven-wind model to produce the lighter r-process isotopes. Moreover, we show that the relative contributions to the r-process abundances in both the solar system and metal-poor stars from the weak, main, and fission-recycling environments required by this proposal are consistent with estimates of the relative Galactic event rates of core-collapse supernovae for the weak and main r-process and NSMs for the fission-recycling r-process.

  12. The Hamburg/ESO R-process Enhanced Star survey (HERES). X. HE 2252-4225, one more r-process enhanced and actinide-boost halo star

    NASA Astrophysics Data System (ADS)

    Mashonkina, L.; Christlieb, N.; Eriksson, K.

    2014-09-01

    Context. Studies of the r-process enhanced stars are important for understanding the nature and origin of the r-process better. Aims: We present a detailed abundance analysis of a very metal-poor giant star discovered in the HERES project, HE 2252-4225, which exhibits overabundances of the r-process elements with [r/Fe] = +0.80. Methods: We determined the stellar atmosphere parameters, Teff = 4710 K, log g = 1.65, and [ Fe/H ] = -2.63, and chemical abundances by analysing the high-quality VLT/UVES spectra. The surface gravity was calculated from the non-local thermodynamic equilibrium (NLTE) ionisation balance between Fe i and Fe ii. Results: Accurate abundances for a total of 38 elements, including 22 neutron-capture elements beyond Sr and up to Th, were determined in HE 2252-4225. For every chemical species, the dispersion in the single line measurements around the mean does not exceed 0.12 dex. This object is deficient in carbon, as expected for a giant star with Teff < 4800 K. The stellar Na-Zn abundances are well fitted by the yields of a single supernova of 14.4 M⊙. For the neutron-capture elements in the Sr-Ru, Ba-Yb, and Os-Ir regions, the abundance pattern of HE 2252-4225 is in excellent agreement with the average abundance pattern of the strongly r-process enhanced stars CS 22892-052, CS 31082-001, HE 1219-0312, and HE 1523-091. This suggests a common origin of the first, second, and third r-process peak elements in HE 2252-4225 in the classical r-process. We tested the solar r-process pattern based on the most recent s-process calculations of Bisterzo, Travaglio, Gallino, Wiescher, and Käppeler and found that elements in the range from Ba to Ir match it very well. No firm conclusion can be drawn about the relationship between the first neutron-capture peak elements, Sr to Ru, in HE 2252-4225 and the solar r-process, owing to the uncertainty in the solar r-process. The investigated star has an anomalously high Th/Eu abundance ratio, so that radioactive dating results in a stellar age of τ = 1.5 ± 1.5 Gyr that is not expected for a very metal-poor halo star. Based on observations collected at the European Southern Observatory, Paranal, Chile (Proposal numbers 170.D-0010, and 280.D-5011).Table 3 is only available at the CDS via anonymous ftp to http://cdsarc.u-strasbg.fr (ftp://130.79.128.5) or via http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/569/A43

  13. The Sensitivity of r-PROCESS Nucleosynthesis to the Properties of Neutron-Rich Nuclei

    NASA Astrophysics Data System (ADS)

    Surman, R.; Mumpower, M. R.; Cass, J.; Aprahamian, A.

    2014-09-01

    About half of the heavy elements in the Solar System were created by rapid neutron capture, or r-process, nucleosynthesis. In the r-process, heavy elements are built up via a sequence of neutron captures and beta decays in which an intense neutron flux pushes material out towards the neutron drip line. The nuclear network simulations used to test potential astrophysical scenarios for the r-process therefore require nuclear physics data (masses, beta decay lifetimes, neutron capture rates, fission probabilities) for thousands of nuclei far from stability. Only a small fraction of this data has been experimentally measured. Here we discuss recent sensitivity studies that aim to determine the nuclei whose properties are most crucial for r-process calculations.

  14. The search for the site of the r-process. [rapid neutron capture in stellar nucleosynthesis

    NASA Technical Reports Server (NTRS)

    Cowan, John J.; Cameron, A. G. W.; Truran, J. W.; Sneden, Christopher

    1986-01-01

    A number of sites have been suggested for the r-process, including neutronized cores of exploding supernovae, jets of neutronized matter ejected from the collapse of rotating magnetized stellar cores, the helium and carbon zones of stars undergoing supernova explosions, and helium core flashes in low-mass stars. Despite much work and many advances in nuclear physics, the site or sites of the r-process is still unknown. Observations of metal-poor stars in the halo of the Galaxy indicate r-process production early in the history of the Galaxy and provide important constraints on galactic nucleosynthesis. Further observations of metal-poor stars, along with advances in understanding the nuclear properties of neutron-rich nuclei and improved astrophysical models of stars in the late stages of evolution, should help to identify the site of the r-process.

  15. r-process nucleosynthesis in the high-entropy supernova bubble

    NASA Technical Reports Server (NTRS)

    Meyer, B. S.; Mathews, G. J.; Howard, W. M.; Woosley, S. E.; Hoffman, R. D.

    1992-01-01

    We show that the high-temperature, high-entropy evacuated region outside the recent neutron star in a core-collapse supernova may be an ideal r-process site. In this high-entropy environment it is possible that most nucleons are in the form of free neutrons or bound into alpha particles. Thus, there can be many neutrons per seed nucleus even though the material is not particularly neutron rich. The predicted amount of r-process material ejected per event from this environment agrees well with that required by simple galactic evolution arguments. When averaged over regions of different neutron excess in the supernova ejecta, the calculated r-process abundance curve can give a good representation of the solar-system r-process abundances as long as the entropy per baryon is sufficiently high. Neutrino irradiation may aid in smoothing the final abundance distribution.

  16. Process Systems Engineering R&D for Advanced Fossil Energy Systems

    SciTech Connect

    Zitney, S.E.

    2007-09-11

    This presentation will examine process systems engineering R&D needs for application to advanced fossil energy (FE) systems and highlight ongoing research activities at the National Energy Technology Laboratory (NETL) under the auspices of a recently launched Collaboratory for Process & Dynamic Systems Research. The three current technology focus areas include: 1) High-fidelity systems with NETL's award-winning Advanced Process Engineering Co-Simulator (APECS) technology for integrating process simulation with computational fluid dynamics (CFD) and virtual engineering concepts, 2) Dynamic systems with R&D on plant-wide IGCC dynamic simulation, control, and real-time training applications, and 3) Systems optimization including large-scale process optimization, stochastic simulation for risk/uncertainty analysis, and cost estimation. Continued R&D aimed at these and other key process systems engineering models, methods, and tools will accelerate the development of advanced gasification-based FE systems and produce increasingly valuable outcomes for DOE and the Nation.

  17. Inferring Nuclear Structure Trends of r-PROCESS Nuclei from β-DECAY Measurements

    NASA Astrophysics Data System (ADS)

    Pereira, J.

    2013-03-01

    The present paper reports on several r-process motivated β-decay experiments undertaken at the National Superconducting Cyclotron Laboratory. β-decay half-lives and β-delayed neutron-emission probabilities were measured for neutron-rich nuclei in the region A=80-110. The data are discussed on the basis of quasi-random phase approximation calculations. The emphasis is made on the impact of these data upon calculations of r-process abundances.

  18. The r-Process in Supersonic Neutrino-Driven Winds: The Roll of Wind Termination Shock

    NASA Astrophysics Data System (ADS)

    Kuroda, Takami; Wanajo, Shinya; Nomoto, Ken'ichi

    2008-05-01

    Recent hydrodynamic studies of core-collapse supernovae imply that the neutrino-heated ejecta from a nascent neutron star develops to supersonic outflows and forms the wind termination shock. We investigate the effects of the termination shock in neutrino-driven winds and its role on the r-process. We find a couple of effects that can be relevant for the r-process. First is the sudden slowdown of the temperature decrease by the wind termination plays a decisive role to determine the r-process abundance curves. This is due to the strong dependences of the nucleosynthetic path on the temperature during the r-process freezeout phase. Second is the entropy jump by termination-shock heating, up to several 100NAk. We, however, find negligible roles of the entropy jump on the r-process. This is a consequence that the sizable entropy increase takes place only at a large shock radius (>~10,000 km) where the r-process has already ceased.

  19. The r-PROCESS in Supernova Explosions from the Collapse of ONeMg Cores

    NASA Astrophysics Data System (ADS)

    Wanajo, Shinya; Itoh, Naoki; Nomoto, Ken'ichi; Ishimaru, Yuhri; Beers, Timothy C.

    2005-12-01

    We examine r-process nucleosynthesis in a "prompt supernova explosion" from an 8 - 10M⊙ progenitor star. In the present model, the progenitor star has formed an oxygen-neon-magnesium core at its center. The core-collapse simulations are performed with a one-dimension, Newtonian hydrodynamic code. We simulate energetic prompt explosions by enhancement of the shock-heating energy, in order to investigate conditions necessary for the production of r-process nuclei in such events. The r-process nucleosynthesis is calculated using a nuclear reaction network code including relevant neutron-rich isotopes with reactions among them. The highly neutronized ejecta (Ye ≈ 0.14 - 0.20) leads to robust production of r-process nuclei; their relative abundances are in excellent agreement with the solar r-process pattern. Our results suggest that prompt explosions of 8 - 10M⊙ stars with oxygen-neon-magnesium cores can be a promising site of r-process nuclei.

  20. Impact of new β-decay half-lives on r-process nucleosynthesis

    NASA Astrophysics Data System (ADS)

    Nishimura, Nobuya; Kajino, Toshitaka; Mathews, Grant J.; Nishimura, Shunji; Suzuki, Toshio

    2012-04-01

    We investigate the effects of newly measured β-decay half-lives on r-process nucleosynthesis. These new rates were determined by recent experiments at the radioactive isotope beam factory facility in the RIKEN Nishina Center. We adopt an r-process nucleosynthesis environment based on a magnetohydrodynamic supernova explosion model that includes strong magnetic fields and rapid rotation of the progenitor. A number of the new β-decay rates are for nuclei on or near the r-process path, and hence they affect the nucleosynthesis yields and time scale of the r-process. The main effect of the newly measured β-decay half-lives is an enhancement in the calculated abundance of isotopes with mass number A=110-120 relative to calculated abundances based upon β-decay rates estimated with the finite-range droplet mass model. This effect slightly alleviates, but does not fully explain, the tendency of r-process models to underproduce isotopes with A=110-120 compared to the solar-system r-process abundances.

  1. The production of transuranium elements by the r-process nucleosynthesis

    NASA Astrophysics Data System (ADS)

    Goriely, S.; Martínez Pinedo, G.

    2015-12-01

    The production of super-heavy transuranium elements by stellar nucleosynthesis processes remains an open question. The most promising process that could potentially give rise to the formation of such elements is the so-called rapid neutron-capture process, or r-process, known to be at the origin of approximately half of the A > 60 stable nuclei observed in nature. However, despite important efforts, the astrophysical site of the r-process remains unidentified. Here, we study the r-process nucleosynthesis in material that is dynamically ejected by tidal and pressure forces during the merging of binary neutron stars. Neutron star mergers could potentially be the dominant r-process site in the Galaxy, but also due to the extreme neutron richness found in such environment, could potentially synthesise super-heavy elements. R-process nucleosynthesis during the decompression is known to be largely insensitive to the detailed astrophysical conditions because of efficient fission recycling, producing a composition that closely follows the solar r-abundance distribution for nuclei with mass numbers A > 140. During the neutron irradiation, nuclei up to charge numbers Z ≃ 110 and mass number A ≃ 340 are produced, with a major peak production at the N = 184 shell closure, i.e. around A ≃ 280. Super-heavy nuclei with Z > 110 can hardly be produced due to the efficient fission taking place along those isotopic chains. Long-lived transuranium nuclei are inevitably produced by the r-process. The predictions concerning the production of transuranium nuclei remain however very sensitive to the predictions of fission barrier heights for such super-heavy nuclei. More nuclear predictions within different microscopic approaches are needed.

  2. VizieR Online Data Catalog: r- and s- process elements in Milky Way disk (Battistini+, 2016)

    NASA Astrophysics Data System (ADS)

    Battistini, C.; Bensby, T.

    2015-11-01

    We present the elemental abundances of a large sample of F and G dwarfs in the solar neighborhood. The analysis is based on high-resolution spectra obtained with MIKE on the Magellan telescope and FEROS on the ESO 1.5m and 2.2m telescopes. We focused our study on r- and s- process elements, precisely Sr, Zr, La, Ce, Nd, Sm, and Eu. In the following tables we provide stellar parameters for the sample, abundances for the single lines analysed and detailed abundances for Sr, Zr, La, Ce, Nd, Sm, and Eu. (2 data files).

  3. PRODUCTION OF ALL THE r-PROCESS NUCLIDES IN THE DYNAMICAL EJECTA OF NEUTRON STAR MERGERS

    SciTech Connect

    Wanajo, Shinya; Sekiguchi, Yuichiro; Kiuchi, Kenta; Shibata, Masaru; Nishimura, Nobuya; Kyutoku, Koutarou

    2014-07-10

    Recent studies suggest that binary neutron star (NS-NS) mergers robustly produce heavy r-process nuclei above the atomic mass number A ∼ 130 because their ejecta consist of almost pure neutrons (electron fraction of Y {sub e} < 0.1). However, the production of a small amount of the lighter r-process nuclei (A ≈ 90-120) conflicts with the spectroscopic results of r-process-enhanced Galactic halo stars. We present, for the first time, the result of nucleosynthesis calculations based on the fully general relativistic simulation of a NS-NS merger with approximate neutrino transport. It is found that the bulk of the dynamical ejecta are appreciably shock-heated and neutrino processed, resulting in a wide range of Y {sub e} (≈0.09-0.45). The mass-averaged abundance distribution of calculated nucleosynthesis yields is in reasonable agreement with the full-mass range (A ≈ 90-240) of the solar r-process curve. This implies, if our model is representative of such events, that the dynamical ejecta of NS-NS mergers could be the origin of the Galactic r-process nuclei. Our result also shows that radioactive heating after ∼1 day from the merging, which gives rise to r-process-powered transient emission, is dominated by the β-decays of several species close to stability with precisely measured half-lives. This implies that the total radioactive heating rate for such an event can be well constrained within about a factor of two if the ejected material has a solar-like r-process pattern.

  4. The r-process nucleosynthesis during the decompression of neutron star crust material

    SciTech Connect

    Goriely, S.; Bauswein, A.; Janka, H.-T.; Sida, J.-L.; Lemaître, J.-F.; Panebianco, S.

    2014-05-02

    About half of the nuclei heavier than iron observed in nature are produced by the so-called rapid neutron capture process, or r-process, of nucleosynthesis. The identification of the astrophysics site and the specific conditions in which the r-process takes place remains, however, one of the still-unsolved mysteries of modern astrophysics. Another underlying difficulty associated with our understanding of the r-process concerns the uncertainties in the predictions of nuclear properties for the few thousands exotic neutron-rich nuclei involved, for which essentially no experimental data exist. The present paper emphasizes some important future challenges faced by nuclear physics in this problem, particularly in the determination of the nuclear structure properties of exotic neutron-rich nuclei as well as their radiative neutron capture rates and their fission probabilities. These quantities are particularly relevant to determine the composition of the matter resulting from the r-process. Both the astrophysics and the nuclear physics difficulties are critically reviewed with special attention paid to the r-process taking place during the decompression of neutron star matter following the merging of two neutron stars.

  5. The r-process nucleosynthesis during the decompression of neutron star crust material

    NASA Astrophysics Data System (ADS)

    Goriely, S.; Bauswein, A.; Janka, H.-T.; Panebianco, S.; Sida, J.-L.; Lemaître, J.-F.; Hilaire, S.; Dubray, N.

    2016-01-01

    About half of the nuclei heavier than iron observed in nature are produced by the so-called rapid neutron capture process, or r-process, of nucleosynthesis. The identification of the astrophysics site and the specific conditions in which the r-process takes place remains, however, one of the still-unsolved mysteries of modern astrophysics. Another underlying difficulty associated with our understanding of the r-process concerns the uncertainties in the predictions of nuclear properties for the few thousands exotic neutron-rich nuclei involved, for which essentially no experimental data exist. The present paper emphasizes some important future challenges faced by nuclear physics in this problem, particularly in the determination of the nuclear structure properties of exotic neutron-rich nuclei as well as their radiative neutron capture rates and their fission probabilities. These quantities are particularly relevant to determine the composition of the matter resulting from the r-process. Both the astrophysics and the nuclear physics difficulties are critically reviewed with special attention paid to the r-process taking place during the decompression of neutron star matter following the merging of two neutron stars.

  6. Fission modes of neutron-rich nuclei in the r-process nucleosynthesis

    SciTech Connect

    Tatsuda, S.; Yamamoto, K.; Asano, T.; Ohta, M.; Wada, T.; Chiba, S.; Koura, H.; Maruyama, T.; Tachibana, T.; Kajino, T.; Sumiyoshi, K.; Otsuki, K.

    2008-05-21

    The fission fragments mass distribution (FFMD) which is the important nuclear information in the study of the r-process nucleosynthesis is estimated for the neutron-rich nuclei (Z>85) according to the theoretical investigation of the potential energy surface. The details for determining FFMD are discussed. In this paper, the network calculation on the r-process nucleosynthesis is also performed including the data of FFMD. The comparison of the results of the network calculation, with and without the fission processes, is shown.

  7. Isotopic compositions of bismuth, lead, thallium, and mercury from mini r-processing

    NASA Technical Reports Server (NTRS)

    Heymann, D.; Liffman, K.

    1986-01-01

    The yields of stable isotopes of Bi, Pb, Tl and Hg as well as yields of Pb-205 are calculated with a parametrized model for 'mini r-processing' in the Ne, O, C-rich zones of explosive burning in massive stars. The Pb isotopic compositions stand out by their comparatively low Pb-207 yields and by the fact that this r-process variant yields Pb-204 quite abundantly. The average Pb-205/Pb-204 yield ratio of 6.1 is the same order of magnitude as yield ratios deduced for s-processing. The Hg from this mini r-process looks like normal solar-system mercury, but with Hg-196 missing and the light s-isotopes A = 198, 199, 200 and 201 depleted (especially the odd-A species).

  8. Enrichment of r-process Elements in Dwarf Spheroidal Galaxies in Chemo-dynamical Evolution Model

    NASA Astrophysics Data System (ADS)

    Hirai, Yutaka; Ishimaru, Yuhri; Saitoh, Takayuki R.; Fujii, Michiko S.; Hidaka, Jun; Kajino, Toshitaka

    2015-11-01

    The rapid neutron-capture process (r-process) is a major process for the synthesis of elements heavier than iron-peak elements, but the astrophysical site(s) of the r-process has not yet been identified. Neutron star mergers (NSMs) are suggested to be a major r-process site according to nucleosynthesis studies. Previous chemical evolution studies, however, required unlikely short merger times of NSMs to reproduce the observed large star-to-star scatters in the abundance ratios of r-process elements to iron: the [Eu/Fe] of extremely metal-poor stars in the Milky Way (MW) halo. This problem can be solved by considering chemical evolution in dwarf spheroidal galaxies (dSphs), which would be building blocks of the MW and have lower star formation efficiencies than the MW halo. We demonstrate the enrichment of r-process elements in dSphs by NSMs using an N-body/smoothed particle hydrodynamics code. Our high-resolution model reproduces the observed [Eu/Fe] due to NSMs with a merger time of 100 Myr when the effect of metal mixing is taken into account. This is because metallicity is not correlated with time ˜300 Myr from the start of the simulation due to the low star formation efficiency in dSphs. We also confirm that this model is consistent with observed properties of dSphs such as radial profiles and metallicity distribution. The merger time and the Galactic rate of NSMs are suggested to be ≲300 Myr and ˜10-4 year-1, respectively, which are consistent with the values suggested by population synthesis and nucleosynthesis studies. This study supports the argument that NSMs are the major astrophysical site of the r-process.

  9. r-PROCESS NUCLEOSYNTHESIS IN DYNAMICALLY EJECTED MATTER OF NEUTRON STAR MERGERS

    SciTech Connect

    Goriely, Stephane; Bauswein, Andreas; Janka, Hans-Thomas

    2011-09-10

    Although the rapid neutron-capture process, or r-process, is fundamentally important for explaining the origin of approximately half of the stable nuclei with A > 60, the astrophysical site of this process has not been identified yet. Here we study r-process nucleosynthesis in material that is dynamically ejected by tidal and pressure forces during the merging of binary neutron stars (NSs) and within milliseconds afterward. For the first time we make use of relativistic hydrodynamical simulations of such events, defining consistently the conditions that determine the nucleosynthesis, i.e., neutron enrichment, entropy, early density evolution and thus expansion timescale, and ejecta mass. We find that 10{sup -3}-10{sup -2} M{sub sun} are ejected, which is enough for mergers to be the main source of heavy (A {approx}> 140) galactic r-nuclei for merger rates of some 10{sup -5} yr{sup -1}. While asymmetric mergers eject 2-3 times more mass than symmetric ones, the exact amount depends weakly on whether the NSs have radii of {approx}15 km for a 'stiff' nuclear equation of state (EOS) or {approx}12 km for a 'soft' EOS. r-process nucleosynthesis during the decompression becomes largely insensitive to the detailed conditions because of efficient fission recycling, producing a composition that closely follows the solar r-abundance distribution for nuclei with mass numbers A > 140. Estimating the light curve powered by the radioactive decay heating of r-process nuclei with an approximative model, we expect high emission in the B-V-R bands for 1-2 days with potentially observable longer duration in the case of asymmetric mergers because of the larger ejecta mass.

  10. The r-PROCESS IN THE NEUTRINO-DRIVEN WIND FROM A BLACK-HOLE TORUS

    SciTech Connect

    Wanajo, Shinya; Janka, Hans-Thomas E-mail: thj@mpa-garching.mpg.de

    2012-02-20

    We examine r-process nucleosynthesis in the neutrino-driven wind from the thick accretion disk (or 'torus') around a black hole. Such systems are expected as remnants of binary neutron star or neutron star-black hole mergers. We consider a simplified, analytic, time-dependent evolution model of a 3 M{sub Sun} central black hole surrounded by a neutrino emitting accretion torus with 90 km radius, which serves as basis for computing spherically symmetric neutrino-driven wind solutions. We find that ejecta with modest entropies ({approx}30 per nucleon in units of the Boltzmann constant) and moderate expansion timescales ({approx}100 ms) dominate in the mass outflow. The mass-integrated nucleosynthetic abundances are in good agreement with the solar system r-process abundance distribution if a minimal value of the electron fraction at the charged-particle freezeout, Y{sub e,min} {approx} 0.2, is achieved. In the case of Y{sub e,min} {approx} 0.3, the production of r-elements beyond A {approx} 130 does not reach to the third peak but could still be important for an explanation of the abundance signatures in r-process deficient stars in the early Galaxy. The total mass of the ejected r-process nuclei is estimated to be {approx}1 Multiplication-Sign 10{sup -3} M{sub Sun }. If our model was representative, this demands a Galactic event rate of {approx}2 Multiplication-Sign 10{sup -4} yr{sup -1} for black-hole-torus winds from merger remnants to be the dominant source of the r-process elements. Our result thus suggests that black-hole-torus winds from compact binary mergers have the potential to be a major, but probably not the dominant, production site of r-process elements.

  11. r-process Nucleosynthesis in Dynamically Ejected Matter of Neutron Star Mergers

    NASA Astrophysics Data System (ADS)

    Goriely, Stephane; Bauswein, Andreas; Janka, Hans-Thomas

    2011-09-01

    Although the rapid neutron-capture process, or r-process, is fundamentally important for explaining the origin of approximately half of the stable nuclei with A > 60, the astrophysical site of this process has not been identified yet. Here we study r-process nucleosynthesis in material that is dynamically ejected by tidal and pressure forces during the merging of binary neutron stars (NSs) and within milliseconds afterward. For the first time we make use of relativistic hydrodynamical simulations of such events, defining consistently the conditions that determine the nucleosynthesis, i.e., neutron enrichment, entropy, early density evolution and thus expansion timescale, and ejecta mass. We find that 10-3-10-2 M sun are ejected, which is enough for mergers to be the main source of heavy (A >~ 140) galactic r-nuclei for merger rates of some 10-5 yr-1. While asymmetric mergers eject 2-3 times more mass than symmetric ones, the exact amount depends weakly on whether the NSs have radii of ~15 km for a "stiff" nuclear equation of state (EOS) or ~12 km for a "soft" EOS. r-process nucleosynthesis during the decompression becomes largely insensitive to the detailed conditions because of efficient fission recycling, producing a composition that closely follows the solar r-abundance distribution for nuclei with mass numbers A > 140. Estimating the light curve powered by the radioactive decay heating of r-process nuclei with an approximative model, we expect high emission in the B-V-R bands for 1-2 days with potentially observable longer duration in the case of asymmetric mergers because of the larger ejecta mass.

  12. Nuclear robustness of the r process in neutron-star mergers

    NASA Astrophysics Data System (ADS)

    Mendoza-Temis, Joel de Jesús; Wu, Meng-Ru; Langanke, Karlheinz; Martínez-Pinedo, Gabriel; Bauswein, Andreas; Janka, Hans-Thomas

    2015-11-01

    We have performed r -process calculations for matter ejected dynamically in neutron star mergers based on a complete set of trajectories from a three-dimensional relativistic smoothed particle hydrodynamic simulation with a total ejected mass of ˜1.7 ×10-3M⊙ . Our calculations consider an extended nuclear network, including spontaneous, β - and neutron-induced fission and adopting fission yield distributions from the abla code. In particular we have studied the sensitivity of the r -process abundances to nuclear masses by using different models. Most of the trajectories, corresponding to 90% of the ejected mass, follow a relatively slow expansion allowing for all neutrons to be captured. The resulting abundances are very similar to each other and reproduce the general features of the observed r -process abundance (the second and third peaks, the rare-earth peak, and the lead peak) for all mass models as they are mainly determined by the fission yields. We find distinct differences in the predictions of the mass models at and just above the third peak, which can be traced back to different predictions of neutron separation energies for r -process nuclei around neutron number N =130 . In all simulations, we find that the second peak around A ˜130 is produced by the fission yields of the material that piles up in nuclei with A ≳250 due to the substantially longer β -decay half-lives found in this region. The third peak around A ˜195 is generated in a competition between neutron captures and β decays during r -process freeze-out. The remaining trajectories, which contribute 10% by mass to the total integrated abundances, follow such a fast expansion that the r process does not use all the neutrons. This also leads to a larger variation of abundances among trajectories, as fission does not dominate the r -process dynamics. The resulting abundances are in between those associated to the r and s processes. The total integrated abundances are dominated by contributions from the slow abundances and hence reproduce the general features of the observed r -process abundances. We find that, at timescales of weeks relevant for kilonova light curve calculations, the abundance of actinides is larger than the one of lanthanides. This means that actinides can be even more important than lanthanides to determine the photon opacities under kilonova conditions. Moreover, we confirm that the amount of unused neutrons may be large enough to give rise to another observational signature powered by their decay.

  13. The sensitivity of r-process nucleosynthesis to individual nuclear properties

    NASA Astrophysics Data System (ADS)

    Surman, Rebecca

    2014-03-01

    Calculations of rapid neutron capture, or r-process, nucleosynthesis require nuclear data for thousands of nuclei far from stability. We currently have experimental information for only a handful of these nuclei, though many more neutron-rich species are within the reach of current and next generation experimental facilities. Sensitivity studies are one way to get at which of these thousands of nuclear properties are the most crucial to measure for the r process. Our r-process sensitivity studies examine the roles of individual nuclear masses, beta decay rates, neutron capture rates, and beta-delayed neutron emission probabilities in r-process simulations in a variety of potential astrophysical environments. Here we will point out the pieces of nuclear data with the greatest impact on the final r-process abundance pattern and describe the mechanisms by which this influence occurs. This work was supported in part by the Department of Energy under contract DE-FG02-05ER41398 and the National Science Foundation through the Joint Institute for Nuclear Astrophysics grant number PHY0822648.

  14. Quantitative Estimate of the Reaction Dependence of the R-Process Nucleosynthesis

    NASA Astrophysics Data System (ADS)

    Sasaqui, Taka.; Kajino, T.; Otsuki, K.; Mathews, G. J.; Nakamura, T.

    2005-12-01

    Very massive stars ≥ 8M⊙ culminate their evolution by supernova (SN) explosions which are presumed to be most viable candidate for the astrophysical site of heavy r-process nucleosynthesis. In an explosive circumstances of the neutrino-driven winds in gravitational core-collapse Type II SNe, not only heavy neutron-rich nuclei but also light unstable nuclei play the significant roles. We first studied in this article the efficiency and sensitivity of the SN r-process nucleosynthesis to many relevant nuclear reaction rates. Our adopted theoretical method and formulae are very effective, and their successful power has already been established in theoretical studies of the missing solar neutrino problem. We also adopted two different models of the neutrino-driven winds in order to study the dependence of our result on wind models. In this study we found quantitatively that several specific nuclear reactions on light neutron-rich nuclei take very critical keys to the final nucleosynthesis yields of r-process elements [1]. Our numerical result of the sensitivity analysis emphasizes and motivates the importance of future experiments aimed at unambiguously determining the nuclear reaction rates that most strongly affect the SN r-process abundance. It would in turn serve to constrain physical and environmental conditions for successful r-process nucleosynthesis in exploding Type II SNe.

  15. Chemical Process Research Department R and D status report, December 1990

    SciTech Connect

    Not Available

    1990-12-01

    An overview is presented of the 1990 R D program managed by GRI's Chemical Process Department. Tactical objectives, goals, and strategies are summarized for these project areas: Advanced Gas Processing, Advanced Gas Separations Science Technology, Methane Reaction Science, and Biotechnology (Gas Supply Bioengineering, End Use Bioengineering, and Piping Materials Research). An appendix includes technical papers on the natural gas processing program and microorganisms in metallic corrosion, and an outline of the methanotrophic treatment program.

  16. Influence of shell-quenching far from stability on the astrophysical r-process

    NASA Astrophysics Data System (ADS)

    Chen, B.; Dobaczewski, J.; Kratz, K.-L.; Langanke, K.; Pfeiffer, B.; Thielemann, F.-K.; Vogel, P.

    1995-02-01

    Comparison of results from r-process calculations within the waiting-point assumption and the r-process component (Nr,solar) of the solar-system composition of heavy elements, permits to test nuclear structure far from stability. Previous investigations, making use of nuclear mass predictions from global macroscopic-microscopic models, showed abundance deficiencies around A ~= 120 and 140, indicating an overly strong N = 82 strength (some models also showed problems around A ~= 180 related to the N = 126 shell). In this paper we calculate masses based on Skyrme interactions locally around N = 82, within the HF+BCS method with the SIII interaction and the HFB theory with SkP interaction. The shell-quenching obtained in the latter approach results in a considerable improvement of the global Nr,solar fit, indicating a solution to a puzzle existing in r-process nucleosynthesis.

  17. Beta-decay half-lives for the r-process nuclei

    NASA Astrophysics Data System (ADS)

    Panov, I. V.; Lutostansky, Yu. S.; Thielemann, F.-K.

    2016-03-01

    For nucleosynthesis calculations of the r-process it is important to know beta-decay half-lives of short-lived neutron-rich nuclei. In the present paper these characteristics are calculated for an extended number of neutron-rich nuclei, important for the r-process. In our calculations the model description of beta-strength functions based on Finite Fermi-Systems Theory is used. The comparison with other predictions and experimental data is done. It is shown that the accuracy of beta-decay half-lives of short-lived neutron-rich nuclei is increasing with increasing neutron excess and can be used for modeling of nucleosynthesis of heavy nuclei in the r-process. For nuclei heavier than lead the half-lives of neutron-rich nuclei are on average 10 times smaller, than proposed of other predictions.

  18. An expanding vortex site for the r-process in rotating stellar collapse

    NASA Technical Reports Server (NTRS)

    Symbalisty, E. M. D.; Schramm, D. N.; Wilson, J. R.

    1985-01-01

    The astrophysical site of r-process nucleosynthesis is investigated theoretically using two-dimensional expanding-vortex stellar-collapse simulations based on the Eulerian adaptive-mesh MHD code of Symbalisty (1984). The results are presented graphically, and it is found that the classical r-process can be explained as the result of the collapse of the highly rotating iron core of a 15-solar-mass star, in which the angular velocity along the rotation axis reaches a maximum of 1000 rad/s, corresponding to an angular momentum of 3.4 x 10 to the 48th erg/s for the inner 1.5 solar mass. The ejected jets are shown to yield about 0.0004 solar mass per supernova, sufficient to explain the observed abundances of r-process products.

  19. Beta-decay spectroscopy relevant to the r-process nucleosynthesis

    SciTech Connect

    Nishimura, Shunji; Collaboration: RIBF Decay Collaboration

    2012-11-12

    A scientific program of beta-decay spectroscopy relevant to r-process nucleosynthesis has been started using high intensity U-beam at the RIBF. The first results of {beta}-decay half-lives of very neutron-rich Kr to Tc nuclides, all of which lie close to the r-process path, suggest a systematic enhancement of the the {beta}-decay rates of the Zr and Nb isotopes around A110 with respect to the predictions of the deformed quasiparticle-random-phase-approximation model (FRDM + QRPA). An impact of the results on the astrophysical r-process is discussed together with the future perspective of the {beta}-decay spectroscopy with the EURICA.

  20. First Results from the CARIBU Facility: Mass Measurements on the r-Process Path

    NASA Astrophysics Data System (ADS)

    Van Schelt, J.; Lascar, D.; Savard, G.; Clark, J. A.; Bertone, P. F.; Caldwell, S.; Chaudhuri, A.; Levand, A. F.; Li, G.; Morgan, G. E.; Orford, R.; Segel, R. E.; Sharma, K. S.; Sternberg, M. G.

    2013-08-01

    The Canadian Penning Trap mass spectrometer has made mass measurements of 33 neutron-rich nuclides provided by the new Californium Rare Isotope Breeder Upgrade facility at Argonne National Laboratory. The studied region includes the Sn132 double shell closure and ranges in Z from In to Cs, with Sn isotopes measured out to A=135, and the typical measurement precision is at the 100 ppb level or better. The region encompasses a possible major waiting point of the astrophysical r process, and the impact of the masses on the r process is shown through a series of simulations. These first-ever simulations with direct mass information on this waiting point show significant increases in waiting time at Sn and Sb in comparison with commonly used mass models, demonstrating the inadequacy of existing models for accurate r-process calculations.

  1. Evidence for supernova injection into the solar nebula and the decoupling of r-process nucleosynthesis

    PubMed Central

    Brennecka, Gregory A.; Borg, Lars E.; Wadhwa, Meenakshi

    2013-01-01

    The isotopic composition of our Solar System reflects the blending of materials derived from numerous past nucleosynthetic events, each characterized by a distinct isotopic signature. We show that the isotopic compositions of elements spanning a large mass range in the earliest formed solids in our Solar System, calcium–aluminum-rich inclusions (CAIs), are uniform, and yet distinct from the average Solar System composition. Relative to younger objects in the Solar System, CAIs contain positive r-process anomalies in isotopes A < 140 and negative r-process anomalies in isotopes A > 140. This fundamental difference in the isotopic character of CAIs around mass 140 necessitates (i) the existence of multiple sources for r-process nucleosynthesis and (ii) the injection of supernova material into a reservoir untapped by CAIs. A scenario of late supernova injection into the protoplanetary disk is consistent with formation of our Solar System in an active star-forming region of the galaxy. PMID:24101483

  2. r-Process Nucleosynthesis in Hot Accretion Disk Flows from Black Hole - Neutron Star Mergers

    SciTech Connect

    Surman, Rebecca; Mclaughlin, Gail C; Ruffert, Maximilian; Janka, Hans-Thomas; Hix, William Raphael

    2008-01-01

    We consider hot accretion disk outflows from black hole-neutron star mergers in the context of the nucleosynthesis they produce. We begin with a three-dimensional numerical model of a black hole-neutron star merger and calculate the neutrino and antineutrino fluxes emitted from the resulting accretion disk. We then follow the element synthesis in material outflowing the disk along parameterized trajectories. We find that at least a weak r-process is produced, and in some cases a main r-process as well. The neutron-rich conditions required for this production of r-process nuclei stem directly from the interactions of the neutrinos emitted by the disk with the free neutrons and protons in the outflow.

  3. Evidence for supernova injection into the solar nebula and the decoupling of r-process nucleosynthesis.

    PubMed

    Brennecka, Gregory A; Borg, Lars E; Wadhwa, Meenakshi

    2013-10-22

    The isotopic composition of our Solar System reflects the blending of materials derived from numerous past nucleosynthetic events, each characterized by a distinct isotopic signature. We show that the isotopic compositions of elements spanning a large mass range in the earliest formed solids in our Solar System, calcium-aluminum-rich inclusions (CAIs), are uniform, and yet distinct from the average Solar System composition. Relative to younger objects in the Solar System, CAIs contain positive r-process anomalies in isotopes A < 140 and negative r-process anomalies in isotopes A > 140. This fundamental difference in the isotopic character of CAIs around mass 140 necessitates (i) the existence of multiple sources for r-process nucleosynthesis and (ii) the injection of supernova material into a reservoir untapped by CAIs. A scenario of late supernova injection into the protoplanetary disk is consistent with formation of our Solar System in an active star-forming region of the galaxy. PMID:24101483

  4. Impact of individual nuclear masses on r-process abundances

    SciTech Connect

    Mumpower, M. R.; Surman, R.; Fang, D. -L.; Beard, M.; Möller, P.; Kawano, T.; Aprahamian, A.

    2015-09-15

    We have performed for the first time a comprehensive study of the sensitivity of r-process nucleosynthesis to individual nuclear masses across the chart of nuclides. Using the latest version (2012) of the Finite-Range Droplet Model, we consider mass variations of ±0.5 MeV and propagate each mass change to all affected quantities, including Q values, reaction rates, and branching ratios. We find such mass variations can result in up to an order of magnitude local change in the final abundance pattern produced in an r-process simulation. As a result, we identify key nuclei whose masses have a substantial impact on abundance predictions for hot, cold, and neutron star merger r-process scenarios and could be measured at future radioactive beam facilities.

  5. Neutron Rich Nuclei in a New Binding Energy Formula and the Astrophysical r-PROCESS

    NASA Astrophysics Data System (ADS)

    Lahiri, Chirashree; Gangopadhyay, G.

    Neutron rich nuclei has been studied with a new phenomenological mass formula. Predictions of different mass formulas for the location of the neutron drip line are compared with those from the present calculation. The implications of the new mass formula for r-process nucleosynthesis are discussed. It is found that though the neutron drip line obtained from this formula differs substantially from other formulas, the r-process abundance upto mass 200 are unlikely to be significantly different. The errors inherent in the mass formula are found to play an insignificant role beyond mass A = 80.

  6. Neutron capture on 130Sn during r-process freeze-out

    NASA Astrophysics Data System (ADS)

    Beun, J.; Blackmon, J. C.; Hix, W. R.; McLaughlin, G. C.; Smith, M. S.; Surman, R.

    2009-02-01

    We examine the role of neutron capture on 130Sn during r-process freeze-out in the neutrino-driven wind environment of the core-collapse supernova. We find that the global r-process abundance pattern is sensitive to the magnitude of the neutron capture cross section of 130Sn. The changes to the abundance pattern include not only a relative decrease in the abundance of 130Sn and an increase in the abundance of 131Sn, but also a shift in the distribution of material in the rare earth and third peak regions.

  7. Long, cold, early r process? Neutrino-induced nucleosynthesis in He shells revisited.

    PubMed

    Banerjee, Projjwal; Haxton, W C; Qian, Yong-Zhong

    2011-05-20

    We revisit a ν-driven r-process mechanism in the He shell of a core-collapse supernova, finding that it could succeed in early stars of metallicity Z ≲ 10⁻³ Z(⊙), at relatively low temperatures and neutron densities, producing A ~ 130 and 195 abundance peaks over ~10-20 s. The mechanism is sensitive to the ν emission model and to ν oscillations. We discuss the implications of an r process that could alter interpretations of abundance data from metal-poor stars, and point out the need for further calculations that include effects of the supernova shock. PMID:21668217

  8. PhenomiR: a knowledgebase for microRNA expression in diseases and biological processes

    PubMed Central

    2010-01-01

    In recent years, microRNAs have been shown to play important roles in physiological as well as malignant processes. The PhenomiR database http://mips.helmholtz-muenchen.de/phenomir provides data from 542 studies that investigate deregulation of microRNA expression in diseases and biological processes as a systematic, manually curated resource. Using the PhenomiR dataset, we could demonstrate that, depending on disease type, independent information from cell culture studies contrasts with conclusions drawn from patient studies. PMID:20089154

  9. Neutron Capture on 130Sn during r-Process Freeze-Out

    SciTech Connect

    Beun, Joshua; Blackmon, Jeffery C; Hix, William Raphael; Mclaughlin, Gail C; Smith, Michael Scott; Surman, Rebecca

    2009-01-01

    We examine the role of neutron capture on {sup 130}Sn during r-process freeze-out in the neutrino-driven wind environment of the core-collapse supernova. We find that the global r-process abundance pattern is sensitive to the magnitude of the neutron capture cross section of {sup 130}Sn. The changes to the abundance pattern include not only a relative decrease in the abundance of {sup 130}Sn and an increase in the abundance of {sup 131}Sn, but also a shift in the distribution of material in the rare earth and third peak regions.

  10. Compact binary mergers as the origin of r-process elements in the Galactic halo

    SciTech Connect

    Ishimaru, Yuhri; Wanajo, Shinya; Prantzos, Nikos

    2014-05-02

    Compact binary mergers (of double neutron star and black hole-neutron star systems) are suggested to be the major site of the r-process elements in the Galaxy by recent hydrodynamical and nucleosynthesis studies. It has been pointed out, however, that estimated long lifetimes of compact binaries are in conflict with the presence of r-process-enhanced stars at the metallicity [Fe/H] ∼ −3. To resolve this problem, we examine the role of compact binary mergers in the early Galactic chemical evolution on the assumption that our Galactic halo was formed from merging sub-halos. The chemical evolutions are modeled for sub-halos with their total stellar masses between 10{sup 4}M{sub ⊙} and 2 × 10{sup 8}M{sub ⊙}. The lifetimes of compact binaries are assumed to be 100 Myr (95%) and 1 Myr (5%) according to recent binary population synthesis studies. We find that the r-process abundances (relative to iron; [r/Fe]) start increasing at [Fe/H] ≤ −3 if the star formation rates are smaller for less massive sub-halos. Our models also suggest that the star-to-star scatter of [r/Fe]'s observed in Galactic halo stars can be interpreted as a consequence of greater gas outflow rates for less massive sub-halos. In addition, the sub-solar [r/Fe]'s (observed as [Ba/Fe] ∼ −1.5 for [Fe/H] < −3) are explained by the contribution from the short-lived (∼ 1 Myr) binaries. Our result indicates, therefore, that compact binary mergers can be potentially the origin of the r-process elements throughout the Galactic history.

  11. Approaching the precursor nuclei of the third r-process peak with RIBs

    NASA Astrophysics Data System (ADS)

    Domingo-Pardo, C.; Caballero-Folch, R.; Agramunt, J.; Algora, A.; Arcones, A.; Ameil, F.; Ayyad, Y.; Benlliure, J.; Bowry, M.; Calviño, F.; Cano-Ott, D.; Cortés, G.; Davinson, T.; Dillmann, I.; Estrade, A.; Evdokimov, A.; Faestermann, T.; Farinon, F.; Galaviz, D.; García-Rios, A.; Geissel, H.; Gelletly, W.; Gernhäuser, R.; Gómez-Hornillos, M. B.; Guerrero, C.; Heil, M.; Hinke, C.; Knöbel, R.; Kojouharov, I.; Kurcewicz, J.; Kurz, N.; Litvinov, Y.; Maier, L.; Marganiec, J.; Marta, M.; Martínez, T.; Martínez-Pinedo, G.; Meyer, B. S.; Montes, F.; Mukha, I.; Napoli, D. R.; Nociforo, Ch; Paradela, C.; Pietri, S.; Podolyák, Z.; Prochazka, A.; Rice, S.; Riego, A.; Rubio, B.; Schaffner, H.; Scheidenberger, Ch; Smith, K.; Sokol, E.; Steiger, K.; Sun, B.; Taín, J. L.; Takechi, M.; Testov, D.; Weick, H.; Wilson, E.; Winfield, J. S.; Wood, R.; Woods, P.; Yeremin, A.

    2016-01-01

    The rapid neutron nucleosynthesis process involves an enormous amount of very exotic neutron-rich nuclei, which represent a theoretical and experimental challenge. Two of the main decay properties that affect the final abundance distribution the most are half-lives and neutron branching ratios. Using fragmentation of a primary 238U beam at GSI we were able to measure such properties for several neutron-rich nuclei from 208Hg to 218Pb. This contribution provides a short update on the status of the data analysis of this experiment, together with a compilation of the latest results published in this mass region, both experimental and theoretical. The impact of the uncertainties connected with the beta-decay rates and with beta-delayed neutron emission is illustrated on the basis of r-process network calculations. In order to obtain a reasonable reproduction of the third r-process peak, it is expected that both half-lives and neutron branching ratios are substantially smaller, than those based on FRDM+QRPA, commonly used in r-process model calculations. Further measurements around N ∼ 126 are required for a reliable modelling of the underlying nuclear structure, and for performing more realistic r-process abundance calculations.

  12. The impact of individual nuclear properties on r-process nucleosynthesis

    NASA Astrophysics Data System (ADS)

    Mumpower, M. R.; Surman, R.; McLaughlin, G. C.; Aprahamian, A.

    2016-01-01

    The astrophysical rapid neutron capture process or ' r process' of nucleosynthesis is believed to be responsible for the production of approximately half the heavy element abundances found in nature. This multifaceted problem remains one of the greatest open challenges in all of physics. Knowledge of nuclear physics properties such as masses, β-decay and neutron capture rates, as well as β-delayed neutron emission probabilities are critical inputs that go into calculations of r-process nucleosynthesis. While properties of nuclei near stability have been established, much still remains unknown regarding neutron-rich nuclei far from stability that may participate in the r process. Sensitivity studies gauge the astrophysical response of a change in nuclear physics input(s) which allows for the isolation of the most important nuclear properties that shape the final abundances observed in nature. This review summarizes the extent of recent sensitivity studies and highlights how these studies play a key role in facilitating new insight into the r process. The development of these tools promotes a focused effort for state-of-the-art measurements, motivates construction of new facilities and will ultimately move the community toward addressing the grand challenge of 'How were the elements from iron to uranium made?'.

  13. Positioning the neutron drip line and the r-process paths in the nuclear landscape

    NASA Astrophysics Data System (ADS)

    Wang, Rui; Chen, Lie-Wen

    2015-09-01

    Exploring nucleon drip lines and astrophysical rapid neutron capture process (r-process) paths in the nuclear landscape is extremely challenging in nuclear physics and astrophysics. While various models predict a similar proton drip line, their predictions for the neutron drip line and the r-process paths involving heavy neutron-rich nuclei exhibit a significant variation which hampers our accurate understanding of the r-process nucleosynthesis mechanism. By using microscopic density functional theory with a representative set of nonrelativistic and relativistic interactions, we demonstrate for the first time that this variation is mainly due to the uncertainty of nuclear matter symmetry energy Esym(ρsc) at the subsaturation cross density ρsc=0.11 /0.16 ×ρ0 (ρ0 is saturation density), which reflects the symmetry energy of heavy nuclei. By using the recent accurate constraint on Esym(ρsc) from the binding-energy difference of heavy-isotope pairs, we obtain quite precise predictions for the location of the neutron drip line, the r-process paths, and the number of bound nuclei in the nuclear landscape. Our results have important implications on extrapolating the properties of unknown neutron-rich rare isotopes from the data on known nuclei.

  14. Development of Highly Efficient Saving Processes of Rare Earth in R-T-B Permanent Magnet

    NASA Astrophysics Data System (ADS)

    Saguchi, A.; Uesugi, T.; Takigawa, Y.; Higashi, K.

    In this study, cost reduction of manufacturing R (Nd, Pr, and Dy) -T (Fe, Co)-B permanent magnets was investigated. An efficient direct melting recycle of R-T-B magnet scraps and multiple methods for saving Dy were focused. In the former, Decarburization and deoxidation of R-T-B magnet scraps were developed as a pre-treatment technique for conventional induction melting. The decarburized scraps 0.001mass% carbon or less was subsequently deoxidized by calciothermic reduction. The recycled scraps can be used as low cost alloying elements by re-melting. In the latter, the casting conditions for R-T-B alloy with small admixture of Ga and the improved pulverization process of R-T-B magnet alloy were developed. Microstructure of R-T-B magnet alloy with small admixture Ga was optimized by controlling cooling rate during solidification, and its average crystalline size was to be 5 μm. In order to obtain finer R-T-B magnet alloy powder preferable to the coercive force, conditions of hydrogen decrepitation (HD) prior to pulverization were optimized. Specific surface area of the HD magnet alloy was increased with decreasing temperature and hydrogen pressure, and its grindability was verified by Jet milling.

  15. The cytoplasmic mRNA degradation factor Pat1 is required for rRNA processing.

    PubMed

    Muppavarapu, Mridula; Huch, Susanne; Nissan, Tracy

    2016-04-01

    Pat1 is a key cytoplasmic mRNA degradation factor, the loss of which severely increases mRNA half-lives. Several recent studies have shown that Pat1 can enter the nucleus and can shuttle between the nucleus and the cytoplasm. As a result, many nuclear roles have been proposed for Pat1. In this study, we analyzed four previously suggested nuclear roles of Pat1 and show that Pat1 is not required for efficient pre-mRNA splicing or pre-mRNA decay in yeast. However, lack of Pat1 results in accumulation of pre-rRNA processing intermediates. Intriguingly, we identified a novel genetic relationship between Pat1 and the rRNA decay machinery, specifically the exosome and the TRAMP complex. While the pre-rRNA processing intermediates that accumulate in the pat1 deletion mutant are, at least to some extent, recognized as aberrant by the rRNA degradation machinery, it is unlikely that these accumulations are the cause of their synthetic sick relationship. Here, we show that the dysregulation of the levels of mRNAs related to ribosome biogenesis could be the cause of the accumulation of the pre-rRNA processing intermediates. Although our results support a role for Pat1 in transcription, they nevertheless suggest that the primary cause of the dysregulated mRNA levels is most likely due to Pat1's role in mRNA decapping and mRNA degradation. PMID:26918764

  16. WASTE PROCESSING ANNUAL NUCLEAR SAFETY RELATED R AND D REPORT FOR CY2008

    SciTech Connect

    Fellinger, A.

    2009-10-15

    The Engineering and Technology Office of Waste Processing identifies and reduces engineering and technical risks associated with key waste processing project decisions. The risks, and actions taken to mitigate those risks, are determined through technology readiness assessments, program reviews, technology information exchanges, external technical reviews, technical assistance, and targeted technology development and deployment (TDD). The Office of Waste Processing TDD program prioritizes and approves research and development scopes of work that address nuclear safety related to processing of highly radioactive nuclear wastes. Thirteen of the thirty-five R&D approved work scopes in FY2009 relate directly to nuclear safety, and are presented in this report.

  17. The even-odd systematics in R-process nuclide abundances

    NASA Technical Reports Server (NTRS)

    Marti, K.; Suess, H. E.

    1988-01-01

    The paper reports and discusses solar system N(R) abundances for nuclides A greater than 70, obtained as differences between measured solar system abundances and calculated S-process contributions. The abundance peak at A of about 163 in the rare earth element region reveals properties which are similar to those of the R-process peaks corresponding to magic neutron numbers N = 82 and N = 126. Systematic differences in the N(R) abundances of even-A and odd-A nuclides are restricted to specific mass regions. It is concluded that these differences are most probably related to the properties of nuclear species during beta(-) decay to the stability valley.

  18. Astrophysical site(s) of r-process elements in galactic chemodynamical evolution model

    NASA Astrophysics Data System (ADS)

    Hirai, Yutaka; Ishimaru, Yuhri; Saitoh, Takayuki R.; Fujii, Michiko S.; Hidaka, Jun; Kajino, Toshitaka

    2016-02-01

    Astrophysical site(s) of rapid neutron-capture process (r-process) is (are) not identified yet. Although core-collapse supernovae have been regarded as one of the possible candidates of the astrophysical site of r-process, nucleosynthesis studies suggest that serious difficulties in core-collapse supernovae to produce heavy elements with mass number of ≳110. Recent studies show that neutron star mergers (NSMs) can synthesize these elements due to their neutron rich environment. Some chemical evolution studies of the Milky Way halo, however, hardly reproduce the observed star-to-star scatters of the abundance ratios of r-process elements (e.g., Eu) in extremely metal-poor stars. This is because of their low rate (˜ 10-4 yr-1 for a Milky Way size galaxy) and long merger time (≳ 100 Myr). This problem might be solved if the stars in the Galactic halo are consisted of the stars formed in dwarf galaxies where the star formation efficiencies were very low. In this study, we carry out numerical simulations of galactic chemo-dynamical evolution using an N-body/smoothed particle hydrodynamics code. We construct detailed chemo-dynamical evolution model for the Local Group dwarf spheroidal galaxies (dSphs) assuming that the NSMs are the major source of r-process elements. Our models successfully reproduce the observed dispersion in [Eu/Fe] as a function of [Fe/H] if we set merger time of NSMs, ≲ 300 Myr with the Galactic NSM rate of ˜ 10-4 yr-1. In addition, our results are consistent with the observed metallicity distribution of dSphs. In the early phase (≲1 Gyr) of galaxy evolution is constant due to low star formation efficiency of dSphs. This study supports the idea that NSMs are the major site of r-process nucleosynthesis.

  19. The neutrino-induced neutron source in helium shell and r-process nucleosynthesis

    NASA Astrophysics Data System (ADS)

    Nadyozhin, D. K.; Panov, I. V.; Blinnikov, S. I.

    1998-07-01

    The huge neutrino pulse that occurs during the collapse of a massive stellar core, is expected to contribute to the origination of a number of isotopes both of light chemical elements and heavy ones. In particular, evaporation of neutrons from helium nuclei excited by neutrino-nuclear inelastic collisions, may result in the r-process as it was first discussed by Epstein et al. (1988). Here we consider mainly the possibility to obtain the considerable amount of neutrons owing to the neutrino breakup of helium nuclei. It is shown that, in general, the heating of stellar matter due to the neutrino scattering off electrons and the heat released from the neutrino-helium breakup followed by the thermonuclear reactions should be taken into account. On the base of kinetic network, using all the important reactions up to Z=8, the main features and the time-dependent character of the neutrino-driven neutron flux are investigated. The time-dependent densities of free neutrons produced in helium breakup, Y_indis {n}(t), were used to calculate the r-process nucleosynthesis with another full kinetic network for ~ 3200 nuclides. It was found that in the case of metal-deficient stars, Z < 0.01 {Z}_sun, the resulting density of free neutrons seems to be high enough to drive the r-process efficiently under favorable conditions. But it is impossible to obtain a sufficient amount of heavy nuclei in neutrino-induced r-process in a helium shell at radii R > R_indis {cr}~ 10(9) cm. We speculate that to make the neutrino-induced r-process work efficiently in the shell, one has to invoke nonstandard presupernova models in which helium hopefully is closer to the collapsed core owing, for instance, to a large scale mixing or/and rotation and magnetic fields. Apart from this exotic possibility, the neutrino-induced nucleosynthesis in the helium shell is certainly not strong enough to explain the observed solar r-process abundances.

  20. Workshop to Identify R&D Topics on Inferential Process Control

    SciTech Connect

    none,

    2006-07-01

    This report summarizes discussion during a March 22, 2006, workshop on inferential process control, organized as a Sensors and Automation activity of the Department of Energy’s (DOE) Industrial Technologies Program (ITP). The workshop brought together experts from industry and research institutions to identify R&D needs and to clarify the goals and challenges anticipated in developing an industry-usable inferential process control system.

    1. r-Process Elements in EMP stars: Indicators of Inhomogeneous Early Halo Enrichment

      NASA Astrophysics Data System (ADS)

      Andersen, Johannes; Nordström, Birgitta; Thidemann Hansen, Terese

      2015-08-01

      Extremely metal-poor (EMP) halo stars with [Fe/H] below ~ -3 are considered to be fossil records of conditions in the early halo. In the simplest picture where iron is a proxy for overall metallicity and indirectly for time, EMP stars formed before the oldest and most metal-poor Galactic globular clusters. High-resolution spectroscopy with 8m-class telescopes has shown the detailed abundance pattern of these stars to be surprisingly uniform (e.g. Bonifacio+ 2012) and essentially Solar, apart from the α-enhancement typical of SN II nucleosynthesis. A small fraction (~3%) of EMP stars, however, is strongly enhanced in the heaviest (r-process) neutron-capture elements, highlighting that the periodic system of elements was fully populated already this early.These striking departures from the general chemical homogeneity could be produced by local or distant sources. The former case is simple - mass transfer from a binary companion that evolved to produce a highly neutron-rich environment (one or more NS). Alternatively, the r-process elements were formed in a site at interstellar distance and preferentially seeded into the natal clouds of the present-day EMP-r stars. Our long-term, precise monitoring of the radial velocities of a sample of such stars (Hansen+ 2011) disproved the binary hypothesis, which would in fact also fail to explain the existence of r-process poor stars, such as HD 122653. We thus conclude that the chemical enrichment of the early halo was far more complex, patchy and likely anisotropic than assumed in current models of Galactic chemical evolution: The EMP-r stars are not just peculiarities to be ignored, but indicate that a new level of complexity must be invoked. That r-process elements have not (yet) been observed in high-redshift DLA systems is readily explained by their low abundance relative to the lighter species and the rarity of strong enrichment events.

    2. Constraints on Neutron Density and Temperature Conditions for Astrophysical r-PROCESS from Updated Nuclear Masses

      NASA Astrophysics Data System (ADS)

      Xu, X. D.; Sun, B.; Niu, Z. M.; Li, Z.; Meng, J.

      2013-11-01

      Based on the (n, γ) ⇌ (γ, n) equilibrium, the neutron density and temperature conditions required for the r-process are constrained with updated nuclear masses. It is found that the uncertainty of determined neutron density and temperature ranges can be greatly minimized when mass values tabulated in the latest Atomic Mass Evaluation AME2011-preview are employed.

    3. OPACITIES AND SPECTRA OF THE r-PROCESS EJECTA FROM NEUTRON STAR MERGERS

      SciTech Connect

      Kasen, Daniel; Barnes, Jennifer; Badnell, N. R.

      2013-09-01

      Material ejected during (or immediately following) the merger of two neutron stars may assemble into heavy elements through the r-process. The subsequent radioactive decay of the nuclei can power transient electromagnetic emission similar to, but significantly dimmer than, an ordinary supernova. Identifying such events is an important goal of future optical surveys, offering new perspectives on the origin of r-process nuclei and the astrophysical sources of gravitational waves. Predictions of the transient light curves and spectra, however, have suffered from the uncertain optical properties of heavy ions. Here we argue that the opacity of an expanding r-process material is dominated by bound-bound transitions from those ions with the most complex valence electron structure, namely the lanthanides. For a few representative ions, we run atomic structure models to calculate the radiative transition rates for tens of millions of lines. The resulting r-process opacities are orders of magnitude larger than that of ordinary (e.g., iron-rich) supernova ejecta. Radiative transport calculations using these new opacities suggest that the light curves should be longer, dimmer, and redder than previously thought. The spectra appear to be pseudo-blackbody, with broad absorption features, and peak in the infrared ({approx}1 {mu}m). We discuss uncertainties in the opacities and attempt to quantify their impact on the spectral predictions. The results have important implications for observational strategies to find and study the radioactively powered electromagnetic counterparts to neutron star mergers.

    4. r-process nucleosynthesis in the MHD+neutrino-heated collapsar jet

      NASA Astrophysics Data System (ADS)

      Nakamura, K.; Kajino, T.; Mathews, G. J.; Sato, S.; Harikae, S.

      2015-10-01

      It has been proposed that the collapsar scenario for long-duration gamma ray bursts is a possible astrophysical site for r-process nucleosynthesis. Here we present r-process nucleosynthesis calculations based upon a model for a MHD+neutrino-heated collapsar jet. We utilize a relativistic magnetohydrodynamic model that includes ray-tracing neutrino transport to describe the development of the black hole accretion disk and the neutrino heating of the funnel region above the black hole. The late time evolution of the collapsar jet is then evolved using axisymmetric special relativistic hydrodynamics. We employ representative test particles to follow the trajectories in density, temperature, entropy, and electron fraction for material flowing from the accretion disk into the jet until they are several thousand km above the black hole. The evolution of nuclear abundances from nucleons to heavy nuclei for ejected test particle trajectories was solved in a large nuclear reaction network as temperatures fall from 9 × 109 to 3 × 108 K. We show that an r-process-like abundance distribution forms in material ejected in the collapsar jet. The possibility for a signature of collapsar r-process material to be found in metal-poor stars is discussed.

    5. Detailed Chemical Abundances in the r-process-rich Ultra-faint Dwarf Galaxy Reticulum 2

      NASA Astrophysics Data System (ADS)

      Roederer, Ian U.; Mateo, Mario; Bailey, John I., III; Song, Yingyi; Bell, Eric F.; Crane, Jeffrey D.; Loebman, Sarah; Nidever, David L.; Olszewski, Edward W.; Shectman, Stephen A.; Thompson, Ian B.; Valluri, Monica; Walker, Matthew G.

      2016-03-01

      The ultra-faint dwarf (UFD) galaxy Reticulum 2 (Ret 2) was recently discovered in images obtained by the Dark Energy Survey. We have observed the four brightest red giants in Ret 2 at high spectral resolution using the Michigan/Magellan Fiber System. We present detailed abundances for as many as 20 elements per star, including 12 elements heavier than the Fe group. We confirm previous detection of high levels of r-process material in Ret 2 (mean [Eu/Fe] = +1.69 ± 0.05) found in three of these stars (mean [Fe/H] = -2.88 ± 0.10). The abundances closely match the r-process pattern found in the well-studied metal-poor halo star CS 22892-052. Such r-process-enhanced stars have not been found in any other UFD galaxy, though their existence has been predicted by at least one model. The fourth star in Ret 2 ([Fe/H] = -3.42 ± 0.20) contains only trace amounts of Sr ([Sr/Fe] = -1.73 ± 0.43) and no detectable heavier elements. One r-process enhanced star is also enhanced in C (natal [C/Fe] ≈ +1.1). This is only the third such star known, which suggests that the nucleosynthesis sites leading to C and r-process enhancements are decoupled. The r-process-deficient star is enhanced in Mg ([Mg/Fe] = +0.81 ± 0.14), and the other three stars show normal levels of α-enhancement (mean [Mg/Fe] = +0.34 ± 0.03). The abundances of other α and Fe-group elements closely resemble those in UFD galaxies and metal-poor halo stars, suggesting that the nucleosynthesis that led to the large r-process enhancements either produced no light elements or produced light-element abundance signatures indistinguishable from normal supernovae. This paper includes data gathered with the 6.5 m Magellan Telescopes located at Las Campanas Observatory, Chile.

    6. Comparative Analysis of In Vitro processivity of HIV-1 Reverse Transcriptases Containing Mutations 65R, 74V, 184V and 65R+74V

      PubMed Central

      Sharma, Prem L.; Nettles, James; Feldman, Anya; Rapp, Kimberly; Schinazi, Raymond F.

      2009-01-01

      While HIV-1 reverse transcriptase (RT) mutations of M to V at position 184 are commonly observed in the clinic, the double mutation of 65R+74V is rarely seen. It has been demonstrated that rapid R→K reversion occurs at RT codon 65 during replication of HIV-1 in human peripheral blood mononuclear cells containing 65R+74V mutations and that processivity of the RT is reduced relative to wild type. However, clinical studies show that M184V can be detected after several months of therapy interruption, suggesting more effective processivity. Herein, the in vitro RT processivity of genetically engineered M184V and double mutant 65R+74V was compared. Virion-associated RTs of WT pNL4-3, K65R, L74V, M184V and 65R+74V were used to perform RT processivity assays in the presence of trap, poly(rC)-oligo(dG). Both RTs with 184V and 65R+74V mutations exhibited similar processivity when compared with each other and a significantly decreased processivity as compared to WT RT. Both mutant RTs synthesized shorter cDNA molecules (37–42 nt) relative to WT RT, which made longer (65–70 nt) cDNA molecules. Since these surprising biochemical results cannot explain the clinical phenotype, a hypothesis is presented to explain the discrepancy and suggest new approaches for future testing. PMID:19555722

    7. Economic analysis: impact of CS/R process on benzene market

      SciTech Connect

      Spielberger, L.; Klein, J.

      1981-05-01

      Contract No. DE-AC01-78ET10159 (formerly ET-78-C-01-3117) between UOP/SDC and the United States Department of Energy (DOE) requires UOP/SDC to provide specific engineering and technical services to the DOE Office of Coal Processing in support of the Coal Gasification Program. This report covers an economic study on the projected price of benzene through the next decade based on the market factors and production costs. The impact of the CS/R process on the benzene market was evaluated. In addition, the cost of gas from the CS/R process was determined as a function of the byproduct credit for benzene.

    8. CIS Modules Process R&D: Final Technical Report, October 2005 - June 2006

      SciTech Connect

      Tarrant, D. E.; Gay, R. R.

      2006-07-01

      The primary objectives of this subcontract were to: address key near-term technical R&D issues for continued improvement in thin-film PV products; continue process development for increased production capacity; pursue long-term R&D contributing to progress toward the MYTP goals for 2020 to increase the conversion efficiency to 15% and reduce module manufacturing costs to less than $50/m2, thus enabling PV systems with a 30-year lifetime at an installed cost of under $2.00/W; and advance the understanding of the requirements needed to achieve better thin-film PV cell and module performance, greater reliability and market acceptance, and investigate materials systems and new devices that can improve the cost/performance ratio of future thin-film PV factories. The demonstrated and maintained high production yield is a major accomplishment supporting attractive cost projections for CIS. Process R&D at successive levels of CIS production has led to the continued demonstration of the prerequisites for commitment to large-scale commercialization. Process and packaging R&D during this and previous subcontracts has demonstrated the potential for further cost and performance improvements.

    9. Radiative neutron captures by neutron-rich nuclei and the r-process nucleosynthesis

      NASA Astrophysics Data System (ADS)

      Goriely, S.

      1998-09-01

      The radiative neutron capture by neutron-rich nuclei is estimated with an improved description of the electric giant dipole resonance. In addition, 3 major effects affecting the capture rates by exotic neutron-rich nuclei are studied. These concern the existence of a low-energy E1 pygmy resonance, the overestimate of the statistical predictions for resonance-deficient nuclei and the direct capture mechanism. The total (n,γ) reaction rates including these 3 effects are evaluated for 3100 neutron-rich nuclei and used in parametric r-process calculations to analyze their impact on the r-abundance distribution.

    10. Dribble, the Drosophila KRR1p Homologue, Is Involved in rRNA Processing

      PubMed Central

      Chan, H.Y. Edwin; Brogna, Saverio; O'Kane, Cahir J.

      2001-01-01

      The Drosophila dribble (dbe) gene encodes a KH domain protein, homologous to yeast KRR1p. Expression of dbe transcripts is ubiquitous during embryogenesis. Overexpressed Dribble protein is localized in the nucleus and in some cell types in a subregion of the nucleolus. Homozygous dbe mutants die at first instar larval stage. Clonal analyses suggest that dbe+ is required for survival of dividing cells. In dbe mutants, a novel rRNA-processing defect is found and accumulation of an abnormal rRNA precursor is detected. PMID:11359931

    11. The History of R-Process Enrichment in the Milky Way

      NASA Astrophysics Data System (ADS)

      Shen, Sijing; Cooke, Ryan J.; Ramirez-Ruiz, Enrico; Madau, Piero; Mayer, Lucio; Guedes, Javiera

      2015-07-01

      We investigate the production sites and the enrichment history of r-process elements in the Galaxy, as traced by the [Eu/Fe] ratio, using the high resolution, cosmological zoom-in simulation Eris. At z = 0, Eris represents a close analog to the Milky Way, making it the ideal laboratory to understand the chemical evolution of our Galaxy. Eris formally traces the production of oxygen and iron due to supernovae (SNe) Ia and SNe II. We include in post-processing the production of r-process elements from compact binary mergers. Unlike previous studies, we find that the nucleosynthetic products from compact binary mergers can be incorporated into stars of very low metallicity and at early times, even with a minimum delay time of 100 Myr. This conclusion is relatively insensitive to modest variations in the merger rate, minimum delay time, and the delay time distribution. By implementing a first-order prescription for metal mixing, we can further improve the agreement between our model and the data for the chemical evolution of both [?/Fe] and [Eu/Fe]. We argue that compact binary mergers could be the dominant source of r-process nucleosynthesis in the Galaxy.

    12. Hans A. Bethe Prize: Astrophysical, observational and nuclear-physics aspects of r-process nucleosynthesis

      NASA Astrophysics Data System (ADS)

      Kratz, Karl-Ludwig

      2014-03-01

      Guided by the Solar System (S.S.) abundance peaks at A ~= 130 and A ~= 195, the basic mechanisms for the rapid neutron-capture process (the r-process) have been known for over 50 years. However, even today, all proposed scenarios and sites face problems with astrophysical conditions as well as with the necessary nuclear-physics input. In my talk, I will describe efforts in experimental and theoretical nuclear-structure data for modeling today's three groups of r-process ``observables'', i.e. the bulk S.S. isotopic abundances, the elemental abundances in metal-poor halo stars, and peculiar isotopic patterns measured in certain cosmic stardust grains. To set a historical basis, I will briefly recall our site-independent ``waiting-point'' model, with superpositions of neutron-density components and the use of the first global, unified nuclear input based on the mass model FRDM(1992). This approach provided a considerable leap forward in the basic understanding of the required astrophysical conditions, as well as of specific shell-structure properties far from stability. Starting in the early millenium, the above simple model has been replaced by more realistic, dynamical parameter studies within the high-entropy wind scenario of core-collapse supernovae, now with superpositions of entropy (S) and electron-fraction (Ye) components. Furthermore, an improved, global set of nuclear-physics data is used today, based on the new mass model FRDM(2012). With this nuclear and astrophysics parameter combination, a new fit to the S.S. r-abundances will be shown, and its improvements and remaining deficiencies in terms of underlying shell structure will be discussed. Concerning the abundance patterns in metal-poor halo stars, an interpretation of the production of ``r-rich'' (e.g. CS 22892-052) and ``r-poor'' (e.g. HD 122563) stars in terms of different (Ye), S combinations will be presented. Finally, for the third group of ``r-observables'', a possible origin of the anomalous Xe-H pattern in presolar nanodiamonds by the ``main'' component of a ``cold'' r-process is suggested.

    13. Neutrino-Induced Neutral-Current Reaction Cross Sections for r-PROCESS Nuclei

      NASA Astrophysics Data System (ADS)

      Langanke, K.; Kolbe, E.

      2002-11-01

      Neutrino-induced reactions play an important role during and after the r-process, if the latter occurs in an environment with extreme neutrino fluxes such as the neutrino-driven wind model or neutron star mergers. Recently we have evaluated the charged-current neutrino-nucleus cross sections relevant for r-process simulations. We extend our approach here to the neutral-current cross sections. Our tabulation considers neutron-rich nuclei with neutron numbers N=41-135 and charge numbers Z=21-82 and lists total as well as partial neutron spallation cross sections. The calculations have been performed within the random phase approximation considering multipole transitions with J<=3 and both parities. The supernova neutrino spectrum is described by a Fermi-Dirac distribution with various temperature parameters between T=2.8 MeV and T=10 MeV and with the degeneracy parameters α=0 and α=3.

    14. {beta}-delayed neutron emission measurements around the third r-process abundance peak

      SciTech Connect

      Caballero-Folch, R.; Cortes, G.; Calvino, F.; Gomez-Hornillos, M. B.; Riego, A.; Domingo-Pardo, C.; Tain, J. L.; Agramunt, J.; Rubio, B.; Algora, A.; Ameil, F.; Farinon, F.; Heil, M.; Knoebel, R.; Kojouharov, I.; Kurcewicz, J.; Kurz, N.; Litvinov, Y.; Mukha, I.; Nociforo, C.; and others

      2013-06-10

      This contribution summarizes an experiment performed at GSI (Germany) in the neutron-rich region beyond N=126. The aim of this measurement is to provide the nuclear physics input of relevance for r-process model calculations, aiming at a better understanding of the third r-process abundance peak. Many exotic nuclei were measured around {sup 211}Hg and {sup 215}Tl. Final ion identification diagrams are given in this contribution. For most of them, we expect to derive halflives and and {beta}-delayed neutron emission probabilities. The detectors used in this experiment were the Silicon IMplantation and Beta Absorber (SIMBA) detector, based on an array of highly segmented silicon detectors, and the BEta deLayEd Neutron (BELEN) detector, which consisted of 30 3He counters embedded in a polyethylene matrix.

    15. Neutron single particle structure in 131Sn and the r-process

      SciTech Connect

      Kozub, R. L.; Bardayan, Daniel W; Adekola, Aderemi S; Blackmon, Jeff C; Chae, K. Y.; Chipps, K.; Cizewski, J. A.; Erikson, Luke; Hatarik, Robert; Jones, K. L.; Krolas, W.; Liang, J Felix; Ma, Zhanwen; Matei, Catalin; Moazen, Brian; Nesaraja, Caroline D; Pain, Steven D; Shapira, Dan; ShrinerJr., J. F.; Smith, Michael Scott; Swan, T. P.

      2009-01-01

      Recent calculations suggest that, at late times in the r-process, the rate of neutron capture by {sup 130}Sn has a significant impact on nucleosynthesis. Direct capture into low-lying bound states is likely the dominant reaction in the r-process near the N=82 closed shell, so reaction rates are strongly impacted by the properties of neutron single particle states in this region. In order to investigate these properties, we have acquired (d,p) reaction data in the A{approx}132 region in inverse kinematics using {approx}630 MeV beams (4.85 MeV/u for {sup 130}Sn) and CD{sub 2} targets. An array of Si strip detectors, including SIDAR and an early implementation of the new Oak Ridge Rutgers University Barrel Array (ORRUBA), was used to detect reaction products. Preliminary results for the {sup 130}Sn(d,p){sup 131}Sn experiment are reported.

    16. The r-process in black hole-neutron star mergers based on a fully general-relativistic simulation

      NASA Astrophysics Data System (ADS)

      Nishimura, N.; Wanajo, S.; Sekiguchi, Y.; Kiuchi, K.; Kyutoku, K.; Shibata, M.

      2016-01-01

      We investigate the black hole-neutron star binary merger in the contest of the r-process nucleosynthesis. Employing a hydrodynamical model simulated in the framework of full general relativity, we perform nuclear reaction network calculations. The extremely neutron-rich matter with the total mass 0.01 M⊙ is ejected, in which a strong r-process with fission cycling proceeds due to the high neutron number density. We discuss relevant astrophysical issues such as the origin of r-process elements as well as the r-process powered electromagnetic transients.

    17. Solar r-process-constrained actinide production in neutrino-driven winds of supernovae

      NASA Astrophysics Data System (ADS)

      Goriely, S.; Janka, H.-Th.

      2016-04-01

      Long-lived radioactive nuclei play an important role as nucleo-cosmochronometers and as cosmic tracers of nucleosynthetic source activity. In particular nuclei in the actinide region like thorium, uranium, and plutonium can testify to the enrichment of an environment by the still enigmatic astrophysical sources that are responsible for the production of neutron-rich nuclei by the rapid neutron-capture process (r-process). Supernovae and merging neutron-star (NS) or NS-black hole binaries are considered as most likely sources of the r-nuclei. But arguments in favour of one or the other or both are indirect and make use of assumptions; they are based on theoretical models with remaining simplifications and shortcomings. An unambiguous observational determination of a production event is still missing. In order to facilitate searches in this direction, e.g. by looking for radioactive tracers in stellar envelopes, the interstellar medium or terrestrial reservoirs, we provide improved theoretical estimates and corresponding uncertainty ranges for the actinide production (232Th, 235, 236, 238U, 237Np, 244Pu, and 247Cm) in neutrino-driven winds of core-collapse supernovae. Since state-of-the-art supernova models do not yield r-process viable conditions -but still lack, for example, the effects of strong magnetic fields- we base our investigation on a simple analytical, Newtonian, adiabatic and steady-state wind model and consider the superposition of a large number of contributing components, whose nucleosynthesis-relevant parameters (mass weight, entropy, expansion time scale, and neutron excess) are constrained by the assumption that the integrated wind nucleosynthesis closely reproduces the solar system distribution of r-process elements. We also test the influence of uncertain nuclear physics.

    18. Phenopix: a R package to process digital images of a vegetation cover

      NASA Astrophysics Data System (ADS)

      Filippa, Gianluca; Cremonese, Edoardo; Migliavacca, Mirco; Galvagno, Marta; Morra di Cella, Umberto; Richardson, Andrew

      2015-04-01

      Plant phenology is a globally recognized indicator of the effects of climate change on the terrestrial biosphere. Accordingly, new tools to automatically track the seasonal development of a vegetation cover are becoming available and more and more deployed. Among them, near-continuous digital images are being collected in several networks in the US, Europe, Asia and Australia in a range of different ecosystems, including agricultural lands, deciduous and evergreen forests, and grasslands. The growing scientific interest in vegetation image analysis highlights the need of easy to use, flexible and standardized processing techniques. In this contribution we illustrate a new open source package called "phenopix" written in R language that allows to process images of a vegetation cover. The main features include: (i) define of one or more areas of interest on an image and process pixel information within them, (ii) compute vegetation indexes based on red green and blue channels, (iii) fit a curve to the seasonal trajectory of vegetation indexes and extract relevant dates (aka thresholds) on the seasonal trajectory; (iv) analyze image pixels separately to extract spatially explicit phenological information. The utilities of the package will be illustrated in detail for two subalpine sites, a grassland and a larch stand at about 2000 m in the Italian Western Alps. The phenopix package is a cost free and easy-to-use tool that allows to process digital images of a vegetation cover in a standardized, flexible and reproducible way. The software is available for download at the R forge web site (r-forge.r-project.org/projects/phenopix/).

    19. Realistic fission models, new beta-decay half-lives and the r-process in neutron star mergers

      SciTech Connect

      Shibagaki, S.; Kajino, T.; Chiba, S.; Lorusso, G.; Nishimura, S.; Mathews, G. J.

      2014-05-02

      Almost half of heavy nuclei beyond iron are considered to be produced by rapid neutron capture process (r-process). This process occurs in the neutron-rich environment such as core-collapse supernovae or neutron star mergers, but the main production site is still unknown. In the r-process of neutron star mergers, nuclear fission reactions play an important role. Also beta-decay half-lives of magic nuclei are crucial for the r-process. We have carried out r-process nucleosynthesis calculations based upon new theoretical estimates of fission fragment distributions and new beta-decay half-lives for N=82 nuclei measured at RIBF-RIKEN. We investigate the effect of nuclear fission on abundance patterns in the matter ejected from neutron star mergers with two different fission fragment mass distributions. We also discuss how the new experimental beta-decay half-lives affect the r-process.

    20. Neutrino-Induced Charged-Current Reaction Rates for r-PROCESS Nuclei

      NASA Astrophysics Data System (ADS)

      Langanke, K.; Kolbe, E.

      2001-11-01

      Neutrino-induced reactions play an important role during and after the r-process if it occurs in an environment with extreme neutrino fluxes, as in the neutrino-driven wind model or neutron star mergers. The neutrino reactions can excite the daughter nucleus above the neutron threshold, which is quite low for r-process nuclei. Thus the daughter nucleus will decay by emission of one or several neutrons. We have calculated the relevant total (νe, e-) cross sections as well as the partial neutron spallation cross sections for r-process nuclei with neutron numbers N=41-135 and proton numbers Z=21-82. The supernova neutrino spectrum is described by a Fermi-Dirac distribution with various temperature parameters between T=2.8 MeV and T=10 MeV and with the degeneracy parameters α=0 and α=3. Our calculations of the nuclear response are based on the random phase approximation and consider allowed as well as forbidden transitions.

    1. a Review of r-PROCESS Nucleosynthesis in the Collapsar Jet

      NASA Astrophysics Data System (ADS)

      Nakamura, Ko; Kajino, Toshitaka; Mathews, Grant J.; Sato, Susumu; Harikae, Seiji

      2013-10-01

      The collapsar scenario for long-duration gamma ray bursts (GRBs) has been proposed as a possible astrophysical site for r-process nucleosynthesis. We summarize the status of r-process nucleosynthesis calculations of our group and others in the context of a magnetohydrodynamics + neutrino-heated collapsar model. In the simulations of our group, we begin with a relativistic magnetohydrodynamic model including ray-tracing neutrino transport to describe the development of the black hole accretion disk and the neutrino heating of the funnel region above the black hole. The late-time evolution of the associated jet was then followed using axisymmetric special relativistic hydrodynamics. We utilized representative test particles to follow the temperature, entropy, electron fraction and density for material flowing within the jet from ejection from the accretion disk until several thousand kilometer above the black hole as temperatures fall from 9×109 to 3×108 K. The evolution of nuclear abundances from nucleons to heavy nuclei for ejected test particle trajectories has been solved in a large nuclear reaction network. It was found that an r-process-like abundance distribution forms in material ejected in the collapsar jet.

    2. Exploiting pre-rRNA processing in Diamond Blackfan anemia gene discovery and diagnosis.

      PubMed

      Farrar, Jason E; Quarello, Paola; Fisher, Ross; O'Brien, Kelly A; Aspesi, Anna; Parrella, Sara; Henson, Adrianna L; Seidel, Nancy E; Atsidaftos, Eva; Prakash, Supraja; Bari, Shahla; Garelli, Emanuela; Arceci, Robert J; Dianzani, Irma; Ramenghi, Ugo; Vlachos, Adrianna; Lipton, Jeffrey M; Bodine, David M; Ellis, Steven R

      2014-10-01

      Diamond Blackfan anemia (DBA), a syndrome primarily characterized by anemia and physical abnormalities, is one among a group of related inherited bone marrow failure syndromes (IBMFS) which share overlapping clinical features. Heterozygous mutations or single-copy deletions have been identified in 12 ribosomal protein genes in approximately 60% of DBA cases, with the genetic etiology unexplained in most remaining patients. Unlike many IBMFS, for which functional screening assays complement clinical and genetic findings, suspected DBA in the absence of typical alterations of the known genes must frequently be diagnosed after exclusion of other IBMFS. We report here a novel deletion in a child that presented such a diagnostic challenge and prompted development of a novel functional assay that can assist in the diagnosis of a significant fraction of patients with DBA. The ribosomal proteins affected in DBA are required for pre-rRNA processing, a process which can be interrogated to monitor steps in the maturation of 40S and 60S ribosomal subunits. In contrast to prior methods used to assess pre-rRNA processing, the assay reported here, based on capillary electrophoresis measurement of the maturation of rRNA in pre-60S ribosomal subunits, would be readily amenable to use in diagnostic laboratories. In addition to utility as a diagnostic tool, we applied this technique to gene discovery in DBA, resulting in the identification of RPL31 as a novel DBA gene. PMID:25042156

    3. The r-process element abundance with a realistic fission fragment mass distribution

      SciTech Connect

      Chiba, S.; Koura, H.; Maruyama, T.; Ohta, M.; Tatsuda, S.; Wada, T.; Tachibana, T.; Sumiyoshi, K.; Otsuki, K.; Kajino, T.

      2008-05-21

      Effect of the {beta}-delayed fission in r-process abundance is investigated with a realistic model for the fission fragment mass distribution (FFMD). The data base for the FFMD is constructed based on the two-center shell model and multi-dimensional Langevin calculation. The {beta}-decay rates including neutron emission and {beta}-delayed fission are also newly calculated with 2nd version of the the gross theory. The differences appeared in the final element abundance calculated with and without fission process, with different {beta}-delayed fission rates are demonstrated.

    4. The r-process element abundance with a realistic fission fragment mass distribution

      NASA Astrophysics Data System (ADS)

      Chiba, S.; Koura, H.; Maruyama, T.; Ohta, M.; Tatsuda, S.; Wada, T.; Tachibana, T.; Sumiyoshi, K.; Otsuki, K.; Kajino, T.

      2008-05-01

      Effect of the β-delayed fission in r-process abundance is investigated with a realistic model for the fission fragment mass distribution (FFMD). The data base for the FFMD is constructed based on the two-center shell model and multi-dimensional Langevin calculation. The β-decay rates including neutron emission and β-delayed fission are also newly calculated with 2nd version of the the gross theory. The differences appeared in the final element abundance calculated with and without fission process, with different β-delayed fission rates are demonstrated.

    5. Analysis of rRNA processing and translation in mammalian cells using a synthetic 18S rRNA expression system

      PubMed Central

      Burman, Luke G.; Mauro, Vincent P.

      2012-01-01

      Analysis of processing, assembly, and function of higher eukaryotic ribosomal RNA (rRNA) has been hindered by the lack of an expression system that enables rRNA to be modified and then examined functionally. Given the potential usefulness of such a system, we have developed one for mammalian 18S rRNA. We inserted a sequence tag into expansion segment 3 of mouse 18S rRNA to monitor expression and cleavage by hybridization. Mutations were identified that confer resistance to pactamycin, allowing functional analysis of 40S ribosomal subunits containing synthetic 18S rRNAs by selectively blocking translation from endogenous (pactamycin-sensitive) subunits. rRNA constructs were suitably expressed in transfected cells, shown to process correctly, incorporate into ≈15% of 40S subunits, and function normally based on various criteria. After rigorous analysis, the system was used to investigate the importance of sequences that flank 18S rRNA in precursor transcripts. Although deletion analysis supported the requirement of binding sites for the U3 snoRNA, it showed that a large segment of the 5′ external transcribed spacer and the entire first internal transcribed spacer, both of which flank 18S rRNA, are not required. The success of this approach opens the possibility of functional analyses of ribosomes, with applications in basic research and synthetic biology. PMID:22718970

    6. Impact of pnpR, a LysR-type regulator-encoding gene, on the cellular processes of Pseudomonas putida DLL-E4.

      PubMed

      Chen, Qiongzhen; Tu, Hui; Huang, Fei; Wang, Yicheng; Dong, Weiliang; Wang, Wenhui; Li, Zhoukun; Wang, Fei; Cui, Zhongli

      2016-06-01

      LysR-type transcriptional regulators (LTTRs) regulate various cellular processes in bacteria. pnpR is an LTTR-encoding gene involved in the regulation of hydroquinone (HQ) degradation, and its effects on the cellular processes of Pseudomonas putida DLL-E4 were investigated at the physiological, biochemical and molecular levels. Reverse transcription polymerase chain reaction revealed that pnpR positively regulated its own expression and that of the pnpC1C2DECX1X2 operon; additionally, pnpR partially regulated the expression of pnpA when P. putida was grown on para-nitrophenol (PNP) or HQ. Strains DLL-E4 and DLL-ΔpnpR exhibited similar cellular morphologies and growth rates. Transcriptome analysis revealed that pnpR regulated the expression of genes in addition to those involved in PNP degradation. A total of 20 genes were upregulated and 19 genes were downregulated by at least 2-fold in strain DLL-ΔpnpR relative to strain DLL-E4. Bioinformatic analysis revealed putative PnpR-binding sites located in the upstream regions of genes involved in PNP degradation, carbon catabolite repression and other cellular processes. The utilization of L-aspartic acid, L-histidine, L-pyroglutamic acid, L-serine, γ-aminobutyric acid, D,L-lactic acid, D-saccharic acid, succinic acid and L-alaninamide was increased at least 1.3-fold in strain DLL-ΔpnpR as shown by BIOLOG assays, indicating that pnpR plays a potential negative regulation role in the utilization of carbon sources. PMID:27190157

    7. Cosmic neutron-star merger rate and gravitational waves constrained by the r-process nucleosynthesis

      NASA Astrophysics Data System (ADS)

      Vangioni, Elisabeth; Goriely, Stéphane; Daigne, Frédéric; François, Patrick; Belczynski, Krzysztof

      2016-01-01

      The cosmic evolution of the neutron-star merger (NSM) rate can be deduced from the observed cosmic star formation rate. This allows us to estimate the rate expected in the horizon of the gravitational wave detectors advanced Virgo and advanced LIGO and to compare those rates with independent predictions. In this context, the rapid neutron-capture process, or r-process, can be used as a constraint assuming NSM is the main astrophysical site for this nucleosynthetic process. We compute the early cosmic evolution of a typical r-process element, europium. Eu yields from NSM are taken from recent nucleosynthesis calculations. The same approach allows us to compute the cosmic rate of Core-Collapse SuperNovae (CCSNe) and the associated evolution of Eu. We find that the bulk of Eu observations at [Fe/H] > -2.5 can be rather well fitted by either CCSN or NSM scenarios. However, at lower metallicity, the early Eu cosmic evolution favours NSM as the main astrophysical site for the r-process. A comparison between our calculations and spectroscopic observations at very low metallicities allows us to constrain the coalescence time-scale in the NSM scenario to ˜0.1-0.2 Gyr. These values are in agreement with the coalescence time-scales of some observed binary pulsars. Finally, the cosmic evolution of Eu is used to put constraints on (i) the NSM rate, (ii) the merger rate in the horizon of the gravitational wave detectors advanced Virgo/ad LIGO, as well as (iii) the expected rate of electromagnetic counterparts to mergers (`kilonovae') in large near-infrared surveys.

    8. Physics and Process Modeling (PPM) and Other Propulsion R and T. Volume 1; Materials Processing, Characterization, and Modeling; Lifting Models

      NASA Technical Reports Server (NTRS)

      1997-01-01

      This CP contains the extended abstracts and presentation figures of 36 papers presented at the PPM and Other Propulsion R&T Conference. The focus of the research described in these presentations is on materials and structures technologies that are parts of the various projects within the NASA Aeronautics Propulsion Systems Research and Technology Base Program. These projects include Physics and Process Modeling; Smart, Green Engine; Fast, Quiet Engine; High Temperature Engine Materials Program; and Hybrid Hyperspeed Propulsion. Also presented were research results from the Rotorcraft Systems Program and work supported by the NASA Lewis Director's Discretionary Fund. Authors from NASA Lewis Research Center, industry, and universities conducted research in the following areas: material processing, material characterization, modeling, life, applied life models, design techniques, vibration control, mechanical components, and tribology. Key issues, research accomplishments, and future directions are summarized in this publication.

    9. Handing over the baton: connecting medicinal chemistry with process R&D.

      PubMed

      Federsel, Hans-Jurgen

      2008-05-01

      The pharmaceutical industry, as virtually any other industry, is continuously striving to become more effective and efficient. This demand for improving business processes is focused on all parts of the organization-from R&D and manufacturing to marketing and sales. Specifically from an R&D perspective, there are two areas that stand out as having caught more attention than others: attrition and timelines. While the former, so far, has seen relatively small changes for the better, the latter has reached clear targets in reducing the overall time required for the various activities conducted during drug discovery and development phases. For process R&D-the unit accountable for the design and optimization of small-molecule synthetic routes as well as delivery of active substance (API) for clinical and toxicological testing-the key contribution in this respect has been the shortening of lead times for supply of the first batch of material on scale. Thus, applying a work model based on balanced frontloading has shown that this crucial task can be taken off the critical path, and instead of delivering required API amounts several months post candidate drug nomination, the availability can now be guaranteed at or even ahead of reaching this milestone. The paradigm shift that has been necessary in order to reach this goal is the subject of this article. PMID:18560618

    10. R/V Kilo Moana's New Geophysical Instrumentation, Processing Methods, and Online Data Repository

      NASA Astrophysics Data System (ADS)

      Miller, J. E.; Chandler, M. T.; Taylor, B.; Shor, A.; Ferguson, J. S.; Wessel, P.

      2012-12-01

      In 2012 several upgrades were made to the underway geophysical systems on R/V Kilo Moana, which the University of Hawaii School of Ocean and Earth Science and Technology (SOEST) operates as part of the University-National Oceanographic Laboratory System (UNOLS) fleet. New instrumentation includes a Bell BGM-3 forced feedback-type gravimeter, a Kongsberg EM 122 12-kHz receiver array, and a high resolution 70-100 kHz EM 710 multibeam echo sounder. Multibeam acceptance trials carried out in June by the Multibeam Advisory Committee, Gates Acoustic Services and UH-SOEST found that both sonars are performing within expected levels with ~5x water depth (WD) for the EM 710 system in shallow water and ~19 km swath width at 4,700 m depth (~4x WD) for the EM 122 deep water system. UH-SOEST also took steps this year to fulfill its obligation to make Kilo Moana's geophysical data more accessible to the public. After an audit of Kilo Moana data at SOEST, Lamont's Rolling Deck to Repository (R2R) and the National Geophysical Data Center (NGDC), as of July 2012 all National Science Foundation-funded Kilo Moana multibeam, gravity, magnetics, center beam depth and Acoustic Doppler Current Profiler (ADCP) data have been submitted to R2R and any multibeam data over 2 years old is being transferred to NGDC. Because it had previously been difficult to access some of SOEST's geophysical data, updated data processing routines have been developed for converting raw gravity, magnetics, and centerbeam depth data to NGDC's standard marine data exchange format (MGD77) for archival and dissemination by NGDC. MGD77 files are being generated and inspected using rigorous along-track analytical techniques for ~270 surveys dating from 2002 to the present and are being submitted to NGDC. We are also developing an online data portal to further facilitate access to SOEST data.

    11. Puzzling Origin of CEMP-r/s Stars: An Interpretation of Abundance and Enrichment of s- and r-Process Elements from Asymptotic Giant Branch Supernovae

      NASA Astrophysics Data System (ADS)

      Zhang, Jiang; Zhao, Fang; Chen, Yanping; Cui, Wenyuan; Zhang, Bo

      2013-12-01

      CEMP-r/s stars at low metallicity are known as double-enhanced stars that show enhancements of both r-process and s-process elements. The chemical abundances of these very metal-poor stars provide us a lot of information for putting new restraints on models of neutron-capture processes. In this article, we put forward an accreted scenario in which the double enrichment of r-process and s-process elements is caused by a former intermediate-mass Asymptotic Giant Branch (AGB) companion in a detached binary system. As the AGB superwind is only present at the ultimate phase of AGB stars, there is thus a lot of potential that the degenerate-core mass of an intermediate-mass AGB star reaches the Chandrasekhar limit before the AGB superwind. In these circumstances, both s-process elements produced in the AGB shell and r-process elements synthesized in the subsequent explosion would be sprayed contemporaneously and accreted by its companion. Despite similarity to physical conditions of a core-collapse supernova, a major focus in this scenario is the degenerate C-O core surrounded by an envelope of a former intermediate-mass AGB donor that may collapse and explode. Due to the existence of an outer envelope, r-process nucleosynthesis is expected to occur. Hypothesizing the material-rich europium (Eu) accreted by the secondary via the wind from the supernova to be in proportion to the geometric fraction of the companion with respect to the exploding donor star, we find that the estimated yield of Eu (as representative of r-process elements) per AGB supernova event is about 1 × 10-9 M ⊙ ˜ 5 × 10-9 M ⊙. Using the yields of Eu, the overabundance of r-process elements in CEMP-r/s stars can be accounted for. The calculated results show that the value of parameter f , standing for efficiency of wind pollution from the AGB supernova, will reach about 104, which means that the enhanced factor is much larger than unity due to the impact of gravity of the donor and the result of the gravitational focusing effect of the companion.

    12. r-PROCESS Nucleosynthesis in Type-II Supernova Model with Neutron Star Mass ~ 1.4M⊙

      NASA Astrophysics Data System (ADS)

      Terasawa, Mariko

      2002-09-01

      It is generally believed that the r-process occurs under explosive conditions at high neutron density, high temperature, and high entropy. It has been discussed, for sometime, that core-collapse supernovae could provide the most likely environment for such r-process nucleosynthesis. So far, the models of neutrino-driven winds from very massive (M≥ 1.7M⊙) and compact neutron star have proved to get successful r-process abundance pattern. A short expansion time is required to obtain a high neutron-to-seed ratio at moderate entropy. This expansion time is obtained by adopting a high neutron star gravitational mass, M~ 2M⊙, and a neutron star radius of R~ 10 km. However, such a large mass is sometimes criticized from observational viewpoints although several established EOSs for neutron star matter are known to stabilize massive core as far as M≤ 2.2M⊙. Nucleosynthesis in the r-process is strongly dependent on the gravitational mass of the proto-neutron star, and for this reason it is taken to be an adjustable parameter to give good r-process yields. In this paper, we study the effects of the outer boundary conditions of neutrino-driven winds on the r-process nucleosynthesis. We can get a reasonable agreement with the solar system r-process abundance pattern even by adopting the 'standard' 1.4M⊙ mass model for the proto-neutron star.

    13. Beta-delayed neutron emission measurements for r-process nuclei

      NASA Astrophysics Data System (ADS)

      Dillmann, Iris

      2014-09-01

      Beta-delayed neutron- (bn-) emitters play an important, two-fold role in the stellar nucleosynthesis of heavy elements in the ``rapid neutron-capture process'' (r process). On one hand they lead to a detour of the material beta-decaying back to stability. On the other hand, the released neutrons increase the neutron-to-seed ratio, and are re-captured during the freeze-out phase and thus influence the final solar r-abundance curve. A large fraction of the isotopes for r-process nucleosynthesis are not yet experimentally accessible and are located in the ``terra incognita.'' With the next generation of fragmentation and ISOL facilities presently being built or already in operation, one of the main motivation of all projects is the investigation of very neutron-rich isotopes at and beyond the border of presently known nuclei. However, reaching more neutron-rich isotopes means also that multiple neutron-emission becomes the dominant decay mechanism. The investigation of bn-emitters has recently experienced a renaissance. I will show some recent results from a GSI campaign with the BELEN detector, and introduce the program planned for 2015/16 at RIKEN with the ``BRIKEN'' detector. ``BRIKEN'' (``Beta-delayed neutron measurements at RIKEN for nuclear structure, astrophysics, and applications'') is a worldwide effort which combines 3He-neutron counters from groups in Germany, Japan, Russia, Spain, and the USA and the implantation detector AIDA from the UK to the presently largest and most efficient neutron detection setup. Planned first experiments comprise the first-time measurements of 48 b-delayed one-neutron and 24 b-delayed two-neutron emitters in the regions around doubly-magic 78Ni and 132Sn. Even some b-delayed three-neutron emitters in the heavier mass region will be tackled for the first time.

    14. Single Neutron Transfer Experiments Close to the r-Process Path

      SciTech Connect

      Grzywacz-Jones, Kate L; Adekola, Aderemi S; Bardayan, Daniel W; Blackmon, Jeff C; Chae, Kyung Yuk; Chipps, K.; Cizewski, Jolie; Dean, David Jarvis; Erikson, Luke; Fitzgerald, R. P.; Gaddis, A. L.; Greife, U.; Harlin, Christopher W; Hatarik, Robert; Howard, Joshua A; Johnson, Micah; Kozub, R. L.; Liang, J Felix; Livesay, Jake; Ma, Zhanwen; Moazen, Brian; O'Malley, Patrick; Nesaraja, Caroline D; Pain, S. D.; Patterson, N. P.; Paulauskas, Stanley V; Shapira, Dan; ShrinerJr., J. F.; Sissom, D. J.; Smith, Michael Scott; Swan, T. P.; Thomas, J. S.

      2007-01-01

      The first measurements using the (d, p) transfer reaction to study single- particle states in nuclei on the expected r-process path have been made at the Holifield Radioactive Ion Beam Facility. The shell closure at N = 50 has been crossed using the 82Ge(d, p) and 84Se(d, p) reactions. The prop- erties of the lowest-lying states have been determined. Furthermore, the 132Sn(d, p) reaction has been used for the first time to populate single- particle states in 133Sn.

    15. Re-187, recycling r-process elements through stars, and the age of the Galaxy.

      NASA Technical Reports Server (NTRS)

      Talbot, R. J., Jr.

      1973-01-01

      The enhanced beta-decay rate of ionized Re-187 in stars has been studied within the context of a detailed numerical model of the production of r-process elements and their recycling through stars during the course of galactic evolution. It is concluded that the enhanced decay rate does not significantly reduce the Re-Os chronometer age for the Galaxy. Consequently, the Re-187 beta-decay half-life and the Os-186/Os-187 neutron cross-section ratio remain as the significant uncertainties in this chronology. Unlike the uncertainties in other chronologies, both are amenable to laboratory measurements.

    16. Novel technique for constraining r-process (n, γ) reaction rates.

      PubMed

      Spyrou, A; Liddick, S N; Larsen, A C; Guttormsen, M; Cooper, K; Dombos, A C; Morrissey, D J; Naqvi, F; Perdikakis, G; Quinn, S J; Renstrøm, T; Rodriguez, J A; Simon, A; Sumithrarachchi, C S; Zegers, R G T

      2014-12-01

      A novel technique has been developed, which will open exciting new opportunities for studying the very neutron-rich nuclei involved in the r process. As a proof of principle, the γ spectra from the β decay of ^{76}Ga have been measured with the SuN detector at the National Superconducting Cyclotron Laboratory. The nuclear level density and γ-ray strength function are extracted and used as input to Hauser-Feshbach calculations. The present technique is shown to strongly constrain the ^{75}Ge(n,γ)^{76}Ge cross section and reaction rate. PMID:25526121

    17. Half-lives of N = 126 Isotones and the r-Process

      SciTech Connect

      Suzuki, Toshio; Yoshida, Takashi; Utsuno, Yutaka

      2010-08-12

      Beta decays of N = 126 isotones are studied by shell model calculations. Both the Gamow-Teller (GT) and first-forbidden (FF) transitions are taken into account to evaluate the half-lives of the isotones (Z = 64-72) with the use of shell model interactions based on G-matrix. The FF transitions are found to be important to reduce the half-lives by twice to several times of those obtained by the GT contributions only. Possible implications of the short half-lives of the waiting point nuclei on the r-process nucleosynthesis during the supernova explosions are discussed.

    18. rTMS neuromodulation improves electrocortical functional measures of information processing and behavioral responses in autism

      PubMed Central

      Sokhadze, Estate M.; El-Baz, Ayman S.; Sears, Lonnie L.; Opris, Ioan; Casanova, Manuel F.

      2014-01-01

      Objectives: Reports in autism spectrum disorders (ASD) of a minicolumnopathy with consequent deficits of lateral inhibition help explain observed behavioral and executive dysfunctions. We propose that neuromodulation based on low frequency repetitive Transcranial Magnetic Stimulation (rTMS) will enhance lateral inhibition through activation of inhibitory double bouquet interneurons and will be accompanied by improvements in the prefrontal executive functions. In addition we proposed that rTMS will improve cortical excitation/inhibition ratio and result in changes manifested in event-related potential (ERP) recorded during cognitive tests. Materials and Methods: Along with traditional clinical behavioral evaluations the current study used ERPs in a visual oddball task with illusory figures. We compared clinical, behavioral and electrocortical outcomes in two groups of children with autism (TMS, wait-list group). We predicted that 18 session long course in autistic patients will have better behavioral and ERP outcomes as compared to age- and IQ-matched WTL group. We used 18 sessions of 1 Hz rTMS applied over the dorso-lateral prefrontal cortex in 27 individuals with ASD diagnosis. The WTL group was comprised of 27 age-matched subjects with ASD tested twice. Both TMS and WTL groups were assessed at the baseline and after completion of 18 weekly sessions of rTMS (or wait period) using clinical behavioral questionnaires and during performance on visual oddball task with Kanizsa illusory figures. Results: Post-TMS evaluations showed decreased irritability and hyperactivity on the Aberrant Behavior Checklist (ABC), and decreased stereotypic behaviors on the Repetitive Behavior Scale (RBS-R). Following rTMS course we found decreased amplitude and prolonged latency in the frontal and fronto-central N100, N200 and P300 (P3a) ERPs to non-targets in active TMS treatment group. TMS resulted in increase of P2d (P2a to targets minus P2a to non-targets) amplitude. These ERP changes along with increased centro-parietal P100 and P300 (P3b) to targets are indicative of more efficient processing of information post-TMS treatment. Another important finding was decrease of the latency and increase of negativity of error-related negativity (ERN) during commission errors that may reflect improvement in error monitoring and correction function. Enhanced information processing was also manifested in lower error rate. In addition we calculated normative post-error treaction time (RT) slowing response in both groups and found that rTMS treatment was accompanied by post-error RT slowing and higher accuracy of responses, whereas the WTL group kept on showing typical for ASD post-error RT speeding and higher commission and omission error rates. Conclusion: Results from our study indicate that rTMS improves executive functioning in ASD as evidenced by normalization of ERP responses and behavioral reactions (RT, accuracy) during executive function test, and also by improvements in clinical evaluations. PMID:25147508

    19. Mass Measurements beyond the Major r-Process Waiting Point {sup 80}Zn

      SciTech Connect

      Baruah, S.; Herlert, A.; Schweikhard, L.; Audi, G.; Guenaut, C.; Lunney, D.; Blaum, K.; George, S.; Dworschak, M.; Herfurth, F.; Yazidjian, C.; Hager, U.; Kellerbauer, A.; Kluge, H.-J.; Schatz, H.

      2008-12-31

      High-precision mass measurements on neutron-rich zinc isotopes {sup 71m,72-81}Zn have been performed with the Penning trap mass spectrometer ISOLTRAP. For the first time, the mass of {sup 81}Zn has been experimentally determined. This makes {sup 80}Zn the first of the few major waiting points along the path of the astrophysical rapid neutron-capture process where neutron-separation energy and neutron-capture Q-value are determined experimentally. The astrophysical conditions required for this waiting point and its associated abundance signatures to occur in r-process models can now be mapped precisely. The measurements also confirm the robustness of the N=50 shell closure for Z=30.

    20. MODISTools – downloading and processing MODIS remotely sensed data in R

      PubMed Central

      Tuck, Sean L; Phillips, Helen RP; Hintzen, Rogier E; Scharlemann, Jörn PW; Purvis, Andy; Hudson, Lawrence N

      2014-01-01

      Remotely sensed data – available at medium to high resolution across global spatial and temporal scales – are a valuable resource for ecologists. In particular, products from NASA's MODerate-resolution Imaging Spectroradiometer (MODIS), providing twice-daily global coverage, have been widely used for ecological applications. We present MODISTools, an R package designed to improve the accessing, downloading, and processing of remotely sensed MODIS data. MODISTools automates the process of data downloading and processing from any number of locations, time periods, and MODIS products. This automation reduces the risk of human error, and the researcher effort required compared to manual per-location downloads. The package will be particularly useful for ecological studies that include multiple sites, such as meta-analyses, observation networks, and globally distributed experiments. We give examples of the simple, reproducible workflow that MODISTools provides and of the checks that are carried out in the process. The end product is in a format that is amenable to statistical modeling. We analyzed the relationship between species richness across multiple higher taxa observed at 526 sites in temperate forests and vegetation indices, measures of aboveground net primary productivity. We downloaded MODIS derived vegetation index time series for each location where the species richness had been sampled, and summarized the data into three measures: maximum time-series value, temporal mean, and temporal variability. On average, species richness covaried positively with our vegetation index measures. Different higher taxa show different positive relationships with vegetation indices. Models had high R2 values, suggesting higher taxon identity and a gradient of vegetation index together explain most of the variation in species richness in our data. MODISTools can be used on Windows, Mac, and Linux platforms, and is available from CRAN and GitHub (https://github.com/seantuck12/MODISTools). PMID:25558360

    1. Beta-delayed fission probabilities of transfermium nuclei, involved in the r-process

      NASA Astrophysics Data System (ADS)

      Panov, I.; Lutostansky, Yu; Thielemann, F.-K.

      2016-01-01

      For the nucleosynthesis of heavy and superheavy nuclei fission becomes very important when the r-process runs in a very high neutron density environment. In part, fission is responsible for the formation of heavy nuclei due to the inclusion of fission products as new seed nuclei (fission cycling). More than that, beta-delayed fission, along with spontaneous fission, is responsible in the late stages of the r-process for the suppression of superheavy element yields. For beta-delayed fission probability calculations a model description of the beta-strength- functions is required. Extended theoretical predictions for astro-physical applications were provided long ago, and new predictions also for superheavy nuclei with uptodate nuclear input are needed. For the further extension of data to heavier transactinides the models of strength- functions should be modified, taking into account more complicated level schemes. In our present calculations the strength-function model is based on the quasi-particle approximation of Finite Fermi Systems Theory. The probabilities of beta-delayed fission and beta-delayed neutron emission are calculated for some transfermium neutron-rich nuclei, and the influence of beta-delayed fission upon superheavy element formation is discussed.

    2. Parameter study of r-process lanthanide production and heating rates in kilonovae

      NASA Astrophysics Data System (ADS)

      Lippuner, Jonas; Roberts, Luke F.

      2015-04-01

      Explosive r-process nucleosynthesis in material ejected during compact object mergers may lead to radioactively powered transients called kilonovae. The timescale and peak luminosity of these transients are sensitive to the composition of the material after nuclear burning ceases, as the composition determines the local heating rate from nuclear decays and the opacity. The presence of lanthanides in the ejecta can drastically increase the opacity. We use the new general-purpose nuclear reaction network SkyNet to run a parameter study of r-process nucleosynthesis for a range of initial electron fractions Ye, initial entropies s, and density decay timescales τ. We find that the ejecta is lanthanide-free for Ye >~ 0 . 22 - 0 . 3 , depending on s and τ. The heating rate is insensitive to s and τ, but certain, larger values of Ye lead to reduced heating rates, because single nuclides dominate the heating. With a simple model we estimate the luminosity, time, and effective temperature at the peak of the light curve. Since the opacity is much lower in the lanthanide-free case, we find the luminosity peaks much earlier at ~ 1 day vs. ~ 15 days in the lanthanide-rich cases. Although there is significant variation in the heating rate with Ye, changes in the heating rate do not mitigate the effect of the lanthanides. This research is partially supported by NSF under Award Numbers AST-1333520 and AST-1205732.

    3. MiR-124 Regulates Apoptosis and Autophagy Process in MPTP Model of Parkinson's Disease by Targeting to Bim.

      PubMed

      Wang, Huiqing; Ye, Yongyi; Zhu, Zhiyuan; Mo, Liqian; Lin, Chunnan; Wang, Qifu; Wang, Haoyuan; Gong, Xin; He, Xiaozheng; Lu, Guohui; Lu, Fengfei; Zhang, Shizhong

      2016-03-01

      Parkinson's disease (PD) is the most prevalent movement disorder characterized by selective loss of midbrain dopaminergic (DA) neurons. MicroRNA-124 (miR-124) is abundantly expressed in the DA neurons and its expression level decreases in the 1-methyl-4-pheny-1, 2, 3, 6-tetrahydropyridine (MPTP) model of PD. However, whether the upregulation of miR-124 could attenuate neurodegeneration remains unknown. Here, we employed miR-124 agomir and miR-124 mimics to upregulate miR-124 expression in MPTP-treated mice and MPP(+) -intoxicated SH-SY5Y cells, respectively. We found that loss of DA neurons and striatal dopamine in MPTP-treated mice was significantly reduced by upregulating miR-124. In addition, we identified a target of miR-124, Bim that mediated the neuroprotection of miR-124. Indeed, treatment of miR-124 agomir in MPTP-treated mice inhibited Bim expression, thus suppressing Bax translocation to mitochondria. Moreover, impaired autophagy process in MPTP-treated mice and MPP(+) -intoxicated SH-SY5Y cells characterized as autophagosomes (AP) accumulation and lysosomal depletion were alleviated by the upregulation of miR-124. Taken together, these results indicate that upregulation of miR-124 could regulate apoptosis and impaired autophagy process in the MPTP model of PD, thus reducing the loss of DA neurons. PMID:25976060

    4. The Origins of Light and Heavy R-process Elements Identified by Chemical Tagging of Metal-poor Stars

      NASA Astrophysics Data System (ADS)

      Tsujimoto, Takuji; Shigeyama, Toshikazu

      2014-11-01

      Growing interests in neutron star (NS) mergers as the origin of r-process elements have sprouted since the discovery of evidence for the ejection of these elements from a short-duration γ-ray burst. The hypothesis of a NS merger origin is reinforced by a theoretical update of nucleosynthesis in NS mergers successful in yielding r-process nuclides with A > 130. On the other hand, whether the origin of light r-process elements are associated with nucleosynthesis in NS merger events remains unclear. We find a signature of nucleosynthesis in NS mergers from peculiar chemical abundances of stars belonging to the Galactic globular cluster M15. This finding combined with the recent nucleosynthesis results implies a potential diversity of nucleosynthesis in NS mergers. Based on these considerations, we are successful in the interpretation of an observed correlation between [light r-process/Eu] and [Eu/Fe] among Galactic halo stars and accordingly narrow down the role of supernova nucleosynthesis in the r-process production site. We conclude that the tight correlation by a large fraction of halo stars is attributable to the fact that core-collapse supernovae produce light r-process elements while heavy r-process elements such as Eu and Ba are produced by NS mergers. On the other hand, stars in the outlier, composed of r-enhanced stars ([Eu/Fe] gsim +1) such as CS22892-052, were exclusively enriched by matter ejected by a subclass of NS mergers that is inclined to be massive and consist of both light and heavy r-process nuclides.

    5. THE ORIGINS OF LIGHT AND HEAVY R-PROCESS ELEMENTS IDENTIFIED BY CHEMICAL TAGGING OF METAL-POOR STARS

      SciTech Connect

      Tsujimoto, Takuji; Shigeyama, Toshikazu

      2014-11-01

      Growing interests in neutron star (NS) mergers as the origin of r-process elements have sprouted since the discovery of evidence for the ejection of these elements from a short-duration γ-ray burst. The hypothesis of a NS merger origin is reinforced by a theoretical update of nucleosynthesis in NS mergers successful in yielding r-process nuclides with A > 130. On the other hand, whether the origin of light r-process elements are associated with nucleosynthesis in NS merger events remains unclear. We find a signature of nucleosynthesis in NS mergers from peculiar chemical abundances of stars belonging to the Galactic globular cluster M15. This finding combined with the recent nucleosynthesis results implies a potential diversity of nucleosynthesis in NS mergers. Based on these considerations, we are successful in the interpretation of an observed correlation between [light r-process/Eu] and [Eu/Fe] among Galactic halo stars and accordingly narrow down the role of supernova nucleosynthesis in the r-process production site. We conclude that the tight correlation by a large fraction of halo stars is attributable to the fact that core-collapse supernovae produce light r-process elements while heavy r-process elements such as Eu and Ba are produced by NS mergers. On the other hand, stars in the outlier, composed of r-enhanced stars ([Eu/Fe] ≳ +1) such as CS22892-052, were exclusively enriched by matter ejected by a subclass of NS mergers that is inclined to be massive and consist of both light and heavy r-process nuclides.

    6. Process R&D under the magnifying glass: organization, business model, challenges, and scientific context.

      PubMed

      Federsel, Hans-Jürgen

      2010-08-15

      Initially, the aim is to provide the big picture illustrating the as is situation in the pharmaceutical industry: a lack of productivity resulting in too few products reaching the market; a loss of billions in revenue over the next few years as some of the major megabrands go off patent; a spiraling cost for developing new drugs and taking them through clinical and safety studies. Following on, a look deeper into the organization will offer an insight into the state-of-the-art in a technical function accountable for chemical Process R&D (with a remit to develop scalable, robust, and cost efficient processes for small molecules). The vast majority of compounds already launched in the form of drug products on the market or still being pursued through the phases of discovery and development, fall within the category of small molecules (as opposed to biopharmaceuticals, e.g., proteins, monoclonal antibodies). This typically means molecular weights of <1000Da and puts organic synthesis in the widest sense of the word at the forefront of technologies needed to support R&D programs in the pharma industry. Understandably, the demands on Medicinal Chemistry are quite different to what applies in a Process R&D (PR&D) organization. In the former, making large numbers of potentially interesting molecules, many of which are discarded after testing, is a key driver and for this virtually any synthetic methodology will suffice. For PR&D, however, homing in on selected compounds there is an expectation that the best synthetic routes will be delivered that meet a number of tough criteria, for instance from an environmental and safety point of view, allowing operation on large scale, offering cost competitiveness, avoiding patent infringements, showing sustainability for long-term production, etc. The intention is to focus on issues to be addressed during this transition by providing examples of changes that had to be put in place in order to make the supply of larger amounts of material feasible. At the end some forward looking conclusions will be shared. PMID:20621486

    7. Erbium And The r-Process In The Sun And Metal-poor Stars

      NASA Astrophysics Data System (ADS)

      Lawler, James; Sneden, C.; Cowan, J. J.

      2007-12-01

      Recent laboratory radiative lifetimes accurate to 5% for 8 even-parity and 72 odd-parity levels of Er II (Stockett et al. 2007, J. Phys. B, in press) were combined with emission branching fractions from Fourier transform spectra to determine accurate absolute transition probabilities for 418 lines of Er II. The lines span the UV to IR wavelength range from 289.2 to 1984.1 nm. Our gf-values have been applied to refine the solar photospheric erbium abundance and to determine erbium abundances in 4 metal-poor giant stars with enhanced r-process abundances (those with [Fe/H] < -2, [Eu/Fe] > +0.5). For the Sun we derive log ɛ(Er) = 0.96 ± 0.02 (σ = 0.06 from 8 lines). This value is in excellent agreement with Lodders' (2003, ApJ, 591, 1220) recommended meteoritic abundance: log ɛ(Er) = 0.95 ± 0.03. Combining the new photospheric Er abundance with our earlier study of Eu (log ɛ(Er) = 0.52 ± 0.01; Lawler et al. 2001, ApJ, 563, 1075) yields log ɛ(Er/Eu) = 0.43 for the Sun. The origin of both Er and Eu are attributed predominantly to production in rapid neutron-capture synthesis (the r-process) in solar-system material, 83% and 97% respectively (Simmerer et al. 2004, ApJ, 617, 1091). We therefore applied the new transition data to the spectra of very metal-poor, r-process rich stars CS 22892-052, BD+17 3248, HD 115444, and HD 221170. Between 14 and 21 Er II features were usable in our abundance analyses in these stars. We derived = 0.43 for the four stars, obviously in excellent agreements with the solar value. This work has been supported by the National Science Foundations through grants AST-0506324 to JEL, AST-0607708 to CS, and AST-0707447 to JJC.

    8. SIRT7-dependent deacetylation of the U3-55k protein controls pre-rRNA processing

      PubMed Central

      Chen, Sifan; Blank, Maximilian Felix; Iyer, Aishwarya; Huang, Bingding; Wang, Lin; Grummt, Ingrid; Voit, Renate

      2016-01-01

      SIRT7 is an NAD+-dependent protein deacetylase with important roles in ribosome biogenesis and cell proliferation. Previous studies have established that SIRT7 is associated with RNA polymerase I, interacts with pre-ribosomal RNA (rRNA) and promotes rRNA synthesis. Here we show that SIRT7 is also associated with small nucleolar RNP (snoRNPs) that are involved in pre-rRNA processing and rRNA maturation. Knockdown of SIRT7 impairs U3 snoRNA dependent early cleavage steps that are necessary for generation of 18S rRNA. Mechanistically, SIRT7 deacetylates U3-55k, a core component of the U3 snoRNP complex, and reversible acetylation of U3-55k modulates the association of U3-55k with U3 snoRNA. Deacetylation by SIRT7 enhances U3-55k binding to U3 snoRNA, which is a prerequisite for pre-rRNA processing. Under stress conditions, SIRT7 is released from nucleoli, leading to hyperacetylation of U3-55k and attenuation of pre-rRNA processing. The results reveal a multifaceted role of SIRT7 in ribosome biogenesis, regulating both transcription and processing of rRNA. PMID:26867678

    9. The r-process Nucleosynthesis in the Various Jet-like Explosions of Magnetorotational Core-collapse Supernovae

      NASA Astrophysics Data System (ADS)

      Nishimura, Nobuya; Takiwaki, Tomoya; Thielemann, Friedrich-Karl

      2015-09-01

      The r-process nucleosynthesis in core-collapse supernovae (CC-SNe) is studied, with a focus on the explosion scenario induced by rotation and strong magnetic fields. Nucleosynthesis calculations are conducted based on magneto-hydrodynamical explosion models with a wide range of parameters for initial rotation and magnetic fields. The explosion models are classified in two different types: prompt-magnetic-jet and delayed-magnetic-jet, for which the magnetic fields of proto-neutron stars (PNSs) during collapse and the core-bounce are strong and comparatively moderate, respectively. Following the hydrodynamical trajectories of each explosion model, we confirmed that r-processes successfully occur in the prompt-magnetic-jets, which produce heavy nuclei including actinides. On the other hand, the r-process in the delayed-magnetic-jet is suppressed, which synthesizes only nuclei up to the second peak (A∼ 130). Thus, the r-process in the delayed-magnetic-jets could explain only “weak r-process” patterns observed in metal-poor stars rather than the “main r-process,” represented by the solar abundances. Our results imply that CC-SNe are possible astronomical sources of heavy r-process elements if their magnetic fields are strong enough, while weaker magnetic explosions may produce “weak r-process” patterns (A≲ 130). We show the potential importance and necessity of magneto-rotational SNe for explaining the galactic chemical evolution, as well as abundances of r-process enhanced metal-poor stars. We also examine the effects of the remaining uncertainties in the nature of PNSs due to weak interactions that determine the final neutron-richness of ejecta. Additionally, we briefly discuss radioactive isotope yields in primary jets (e.g., 56Ni), with relation to several optical observation of SNe and relevant high-energy astronomical phenomena.

    10. New Fission Fragment Distributions and r-Process Origin of the Rare-Earth Elements

      NASA Astrophysics Data System (ADS)

      Goriely, S.; Sida, J.-L.; Lemaître, J.-F.; Panebianco, S.; Dubray, N.; Hilaire, S.; Bauswein, A.; Janka, H.-T.

      2013-12-01

      Neutron star (NS) merger ejecta offer a viable site for the production of heavy r-process elements with nuclear mass numbers A≳140. The crucial role of fission recycling is responsible for the robustness of this site against many astrophysical uncertainties, but calculations sensitively depend on nuclear physics. In particular, the fission fragment yields determine the creation of 110≲A≲170 nuclei. Here, we apply a new scission-point model, called SPY, to derive the fission fragment distribution (FFD) of all relevant neutron-rich, fissioning nuclei. The model predicts a doubly asymmetric FFD in the abundant A≃278 mass region that is responsible for the final recycling of the fissioning material. Using ejecta conditions based on relativistic NS merger calculations, we show that this specific FFD leads to a production of the A≃165 rare-earth peak that is nicely compatible with the abundance patterns in the Sun and metal-poor stars. This new finding further strengthens the case of NS mergers as possible dominant origin of r nuclei with A≳140.

    11. Submicron sized R2 Fe14 B particles fabricated by mechanochemical process

      NASA Astrophysics Data System (ADS)

      Koylu-Alkan, Ozlem; Barandiaran, Jose Manuel; Salazar, Daniel; Hadjipanayis, George C.; Univ. of Delaware Team; Univ. Basque Country Team

      In this work, we have synthesized submicron R2Fe14B particles by the mechanochemical process. Mechanical activation of oxides of rare earth, iron and boron was done by high energy ball milling in a CaO with a reduction agent (Ca). After a heat treatment at 900 °C the powder was washed with water and glycerol solution to remove the dispersant and other non-magnetic phases. Magnetic measurements showed that the as-synthesized unwashed powders had coercivity values of 10.3 kOe, 12.8 kOe, and 24.6 kOe for R =Nd, Pr, and Dy, respectively. During washing, H2 is released and absorbed by the 2:14:1 structure. After removing the H2, the submicron particles have coercivities of 3.3 kOe (Nd), 4.4 kOe (Pr) and 21.0 kOe (Dy) with average sizes 160 nm, 242 nm, and 107 nm, respectively. Fitting of high field M(H) measurements to the law of approach to saturation showed that the anisotropy constant of the Nd2Fe14B particles are 3.73x107 erg/cm3 which is comparable to bulk. Work supported by DOE DE-FG02-04ERU4612 and Bizkaia Talent AYD-000-195. DOE DE-FG02-04ERU4612.

    12. β-decay spectroscopy of r-process nuclei with N = 126 at KISS

      SciTech Connect

      Hirayama, Y.; Watanabe, Y. X.; Imai, N.; Ishiyama, H.; Jeong, S. C.; Miyatake, H.; Oyaizu, M.; Kim, Y. H.; Mukai, M.; Kimura, S.

      2014-05-02

      The β-decay properties of nuclei with N = 126, which are believed to act as progenitors in the rapid neutron capture (r-) process path forming the third peak (A ∼ 195) in the observed r-abundance element distribution, are considered critical for understanding the production of heavy elements such as gold and platinum at astrophysical sites. We have constructed the KEK Isotope Separation System (KISS), which consists of a gas cell based laser ion source (atomic number selection) and an isotope separation on-line (ISOL) (mass number selection), to produce pure low-energy beams of neutron-rich isotopes around N = 126 and to study their β-decay properties, which are also of interest for astrophysics. The isotopes of interest will be produced by multi-nucleon transfer reactions in heavy ion collisions (e.g. {sup 136}Xe projectile on {sup 198}Pt target). KISS will allow us to study unknown isotopes produced in weak reaction channels under low background conditions. We successfully extracted the stable {sup 56}Fe beam from KISS at the last commissioning on-line experiment with the extraction efficiency of 0.25% and beam purity of more than 98%. We can access the nuclei with N = 126 and measure their half-lives using the KISS in the case of the extraction efficiency of 0.1%.

    13. The inferior frontal cortex in artificial syntax processing: an rTMS study.

      PubMed

      Uddén, Julia; Folia, Vasiliki; Forkstam, Christian; Ingvar, Martin; Fernandez, Guillen; Overeem, Sebastiaan; van Elswijk, Gijs; Hagoort, Peter; Petersson, Karl Magnus

      2008-08-11

      The human capacity to implicitly acquire knowledge of structured sequences has recently been investigated in artificial grammar learning using functional magnetic resonance imaging. It was found that the left inferior frontal cortex (IFC; Brodmann's area (BA) 44/45) was related to classification performance. The objective of this study was to investigate whether the IFC (BA 44/45) is causally related to classification of artificial syntactic structures by means of an off-line repetitive transcranial magnetic stimulation (rTMS) paradigm. We manipulated the stimulus material in a 2 x 2 factorial design with grammaticality status and local substring familiarity as factors. The participants showed a reliable effect of grammaticality on classification of novel items after 5 days of exposure to grammatical exemplars without performance feedback in an implicit acquisition task. The results show that rTMS of BA 44/45 improves syntactic classification performance by increasing the rejection rate of non-grammatical items and by shortening reaction times of correct rejections specifically after left-sided stimulation. A similar pattern of results is observed in FMRI experiments on artificial syntactic classification. These results suggest that activity in the inferior frontal region is causally related to artificial syntax processing. PMID:18617159

    14. New fission fragment distributions and r-process origin of the rare-earth elements.

      PubMed

      Goriely, S; Sida, J-L; Lemaître, J-F; Panebianco, S; Dubray, N; Hilaire, S; Bauswein, A; Janka, H-T

      2013-12-13

      Neutron star (NS) merger ejecta offer a viable site for the production of heavy r-process elements with nuclear mass numbers A≳140. The crucial role of fission recycling is responsible for the robustness of this site against many astrophysical uncertainties, but calculations sensitively depend on nuclear physics. In particular, the fission fragment yields determine the creation of 110≲A≲170 nuclei. Here, we apply a new scission-point model, called SPY, to derive the fission fragment distribution (FFD) of all relevant neutron-rich, fissioning nuclei. The model predicts a doubly asymmetric FFD in the abundant A≃278 mass region that is responsible for the final recycling of the fissioning material. Using ejecta conditions based on relativistic NS merger calculations, we show that this specific FFD leads to a production of the A≃165 rare-earth peak that is nicely compatible with the abundance patterns in the Sun and metal-poor stars. This new finding further strengthens the case of NS mergers as possible dominant origin of r nuclei with A≳140. PMID:24483647

    15. Dexterity with numbers: rTMS over left angular gyrus disrupts finger gnosis and number processing.

      PubMed

      Rusconi, Elena; Walsh, Vincent; Butterworth, Brian

      2005-01-01

      Since the original description of Gerstmann's syndrome with its four cardinal symptoms, among which are finger agnosia and acalculia, the neuro-cognitive relationship between fingers and calculation has been debated. We asked our participants to perform four different tasks, two of which involved fingers and the other two involving numbers, during repetitive transcranial magnetic stimulation (rTMS) over the posterior parietal lobe of either hemisphere. In the finger tasks, they were required to transform a tactile stimulus randomly delivered on one of their fingers into a speeded key-press response either with the same or with the homologous finger on the opposite hand. In the numerical tasks, they were asked to perform a magnitude or a parity matching on pairs of single digits, in the context of arithmetically related or unrelated numerical primes. In accordance with the original anatomical hypothesis put forward by Gerstmann [Gerstmann, J. (1924). Fingeragnosie: eine umschriebene Stoerung der Orienterung am eigenen Koerper. Wiener clinische Wochenschrift, 37, 1010-12], we found that rTMS over the left angular gyrus disrupted tasks requiring access to the finger schema and number magnitude processing in the same group of participants. In addition to the numerous studies which have employed special populations such as neurological patients and children, our data confirm the presence of a relationship between numbers and body knowledge in skilled adults who no longer use their fingers for solving simple arithmetical tasks. PMID:16009243

    16. J.R. Simplot: Burner Upgrade Project Improves Performance and Saves Energy at a Large Food Processing Plant (Steam)

      SciTech Connect

      2005-09-01

      This DOE Industrial Program case study describes how the J.R. Simplot Company saved energy and money by increasing the efficiency of the steam system in its potato processing plant in Caldwell, Idaho.

    17. J.R. Simplot: Burner Upgrade Project Improves Performance and Saves Energy at a Large Food Processing Plant

      SciTech Connect

      Not Available

      2005-09-01

      This DOE Industrial Program case study describes how the J.R. Simplot Company saved energy and money by increasing the efficiency of the steam system in its potato processing plant in Caldwell, Idaho.

    18. Nonstandard. gamma. gamma. r arrow l sup + l minus processes in relativistic heavy-ion collisions

      SciTech Connect

      Almeida, L.D.; Natale, A.A.; Novaes, S.F. ); Eboli, O.J.P. )

      1991-07-01

      We study lepton pair production in heavy-ion collisions with emphasis on nonstandard contributions to the QED subprocess {gamma}{gamma}{r arrow}{ital l}{sup +}{ital l{minus}}. The existence of compositeness of fermions and/or bosons can be tested in this reaction up to the TeV mass scale. We show that for some processes the capabilities of relativistic heavy-ion colliders to disclose new physics surpass the possibilities of {ital e}{sup +}{ital e{minus}} or {ital p{bar p}} machines. In particular, spin-zero composite particles which couple predominantly to two photons, predicted in composite models, can be studied in a broad range of masses.

    19. {sup 12}B(n,{gamma})--the influence on r-process nucleosynthesis of light elements

      SciTech Connect

      Lee, H. Y.; Jiang, C. L.; Pardo, R. C.; Rehm, K. E.; Schiffer, J. P.; Goodman, N. J.; Lighthall, J. C.; Marley, S. T.; Wuosmaa, A. H.; Notani, M.; Patel, N.; Tang, X.

      2009-03-04

      Because of interest in the {sup 11,12}B(n,{gamma}) reaction in seeding r-process nucleosynthesis through light neutron-rich nuclei, we have measured the {sup 12}B(d,p) reaction for the first time using the ATLAS in-flight facility at Argonne National Laboratory. We also measured the {sup 11}B(d,p) reaction in the same way for calibration. The spectroscopic factors of excited states and the branching ratio of the neutron-unbound state in {sup 12}B are obtained from the current experiment and the reaction rate for {sup 11}B(n,{gamma}) is discussed in comparison with the theoretical prediction.

    20. Developments in precison mass measurements of short-lived r-process nuclei with CARIBU

      NASA Astrophysics Data System (ADS)

      Marley, S. T.; Aprahamian, A.; Mumpower, M.; Nystrom, A.; Paul, N.; Siegl, K.; Strauss, S.; Surman, R.; Clark, J. A.; Perez Galvan, A.; Savard, G.; Morgan, G.; Orford, R.

      2013-10-01

      The confluence of new radioactive beam facilities and modern precision mass spectrometry techniques now make it possible to measure masses of many neutron-rich nuclei important to nuclear structure and astrophysics. A recent mass sensitivity study (S. Brett et al., Eur. Phys. J., A 48, 184 (2012)) identified the nuclear masses that are the most influential to the final rapid-neutron capture process abundance distributions under various astrophysical scenarios. This work motivated a campaign of precision mass measurements using the Canadian Penning Trap (CPT) installed at the Californium Rare Isotope Breeder Upgrade (CARIBU) facility at Argonne National Laboratory. In order to measure the weakest and most short-lived (t1/2 < 150 ms) of these influential nuclei, a series of upgrades to the CARIBU and CPT systems have been developed. The implementation of these upgrades, the r-process mass measurements, and the status of CARIBU facilty will be discussed. This work performed under the auspices of NSERC, Canada, appl. # 216974, the U.S. DOE, Office of Nuclear Physics, under contracts DE-AC02-06CH11357, DE-FG02-91ER-40609, DE-FG02-98ER41086, & DE-AC52-07NA27344, and NSF Grants PHY08-22648 and PHY-106819.

    1. Process R&D for CIS-Based Thin-Film PV: Final Technical Report, April 2002 - April 2005

      SciTech Connect

      Tarrant, D. E.; Gay, R. R.

      2006-01-01

      The primary objectives of this Shell Solar Industries subcontract are to address key near-term technical R&D issues for continued CIS product improvement; continue process development for increased production capacity; develop processes capable of significantly contributing to DOE 2020 PV shipment goals; advance mid- and longer-term R&D needed by industry for future product competitiveness including improving module performance, decreasing production process costs per watt produced, and improving reliability; and perform aggressive module lifetime R&D directed at developing packages that address the DOE goal for modules that will last up to 30 years while retaining 80% of initial power. These production R&D results, production volume, efficiency, high line yield, and advances in understanding are major accomplishments. The demonstrated and maintained high production yield is a major accomplishment supporting attractive cost projections for CIS. Process R&D at successive levels of CIS production has led to the continued demonstration of the prerequisites for commitment to large-scale commercialization. Process and packaging R&D during this and previous subcontracts has demonstrated the potential for further cost and performance improvements.

    2. RNomics in Archaea reveals a further link between splicing of archaeal introns and rRNA processing

      PubMed Central

      Tang, Thean Hock; Rozhdestvensky, Timofey S.; d’Orval, Béatrice Clouet; Bortolin, Marie-Line; Huber, Harald; Charpentier, Bruno; Branlant, Christiane; Bachellerie, Jean-Pierre; Brosius, Jürgen; Hüttenhofer, Alexander

      2002-01-01

      The bulge–helix–bulge (BHB) motif recognised by the archaeal splicing endonuclease is also found in the long processing stems of archaeal rRNA precursors in which it is cleaved to generate pre-16S and pre-23S rRNAs. We show that in two species, Archaeoglobus fulgidus and Sulfolobus solfataricus, representatives from the two major archaeal kingdoms Euryarchaeota and Crenarchaeota, respectively, the pre-rRNA spacers cleaved at the BHB motifs surrounding pre-16S and pre-23S rRNAs subsequently become ligated. In addition, we present evidence that this is accompanied by circularisation of ribosomal pre-16S and pre-23S rRNAs in both species. These data reveal a further link between intron splicing and pre-rRNA processing in Archaea, which might reflect a common evolutionary origin of the two processes. One spliced RNA species designated 16S-D RNA, resulting from religation at the BHB motif of 16S pre-rRNA, is a highly abundant and stable RNA which folds into a three-stem structure interrupted by two single-stranded regions as assessed by chemical probing. It spans a region of the pre-rRNA 5′ external transcribed spacer exhibiting a highly conserved folding pattern in Archaea. Surprisingly, 16S-D RNA contains structural motifs found in archaeal C/D box small RNAs and binds to the L7Ae protein, a core component of archaeal C/D box RNPs. This supports the notion that it might have an important but still unknown role in pre-rRNA biogenesis or might even target RNA molecules other than rRNA. PMID:11842103

    3. AN r-PROCESS KILONOVA ASSOCIATED WITH THE SHORT-HARD GRB 130603B

      SciTech Connect

      Berger, E.; Fong, W.; Chornock, R.

      2013-09-10

      We present ground-based optical and Hubble Space Telescope (HST) optical and near-IR observations of the short-hard GRB 130603B at z = 0.356, which demonstrate the presence of excess near-IR emission matching the expected brightness and color of an r-process powered transient (a {sup k}ilonova{sup )}. The early afterglow fades rapidly with {alpha} {approx}< -2.6 at t Almost-Equal-To 8-32 hr post-burst and has a spectral index of {beta} Almost-Equal-To -1.5 (F{sub {nu}}{proportional_to}t {sup {alpha}}{nu}{sup {beta}}), leading to an expected near-IR brightness at the time of the first HST observation of m{sub F160W}(t = 9.4 days) {approx}> 29.3 AB mag. Instead, the detected source has m{sub F160W} = 25.8 {+-} 0.2 AB mag, corresponding to a rest-frame absolute magnitude of M{sub J} Almost-Equal-To -15.2 mag. The upper limit in the HST optical observations is m{sub F606W} {approx}> 27.7 AB mag (3{sigma}), indicating an unusually red color of V - H {approx}> 1.9 mag. Comparing the observed near-IR luminosity to theoretical models of kilonovae produced by ejecta from the merger of an NS-NS or NS-BH binary, we infer an ejecta mass of M{sub ej} Almost-Equal-To 0.03-0.08 M{sub Sun} for v{sub ej} Almost-Equal-To 0.1-0.3c. The inferred mass matches the expectations from numerical merger simulations. The presence of a kilonova provides the strongest evidence to date that short GRBs are produced by compact object mergers, and provides initial insight on the ejected mass and the primary role that compact object merger may play in the r-process. Equally important, it demonstrates that gravitational wave sources detected by Advanced LIGO/Virgo will be accompanied by optical/near-IR counterparts with unusually red colors, detectable by existing and upcoming large wide-field facilities (e.g., Pan-STARRS, DECam, Subaru, LSST)

    4. COPASutils: An R Package for Reading, Processing, and Visualizing Data from COPAS Large-Particle Flow Cytometers

      PubMed Central

      Shimko, Tyler C.; Andersen, Erik C.

      2014-01-01

      The R package COPASutils provides a logical workflow for the reading, processing, and visualization of data obtained from the Union Biometrica Complex Object Parametric Analyzer and Sorter (COPAS) or the BioSorter large-particle flow cytometers. Data obtained from these powerful experimental platforms can be unwieldy, leading to difficulties in the ability to process and visualize the data using existing tools. Researchers studying small organisms, such as Caenorhabditis elegans, Anopheles gambiae, and Danio rerio, and using these devices will benefit from this streamlined and extensible R package. COPASutils offers a powerful suite of functions for the rapid processing and analysis of large high-throughput screening data sets. PMID:25329171

    5. Impact of weak interactions of free nucleons on the r-process in dynamical ejecta from neutron star mergers

      NASA Astrophysics Data System (ADS)

      Goriely, S.; Bauswein, A.; Just, O.; Pllumbi, E.; Janka, H.-Th.

      2015-10-01

      We investigate β-interactions of free nucleons and their impact on the electron fraction (Ye) and r-process nucleosynthesis in ejecta characteristic of binary neutron star mergers (BNSMs). For that we employ trajectories from a relativistic BNSM model to represent the density-temperature evolutions in our parametric study. In the high-density environment, positron captures decrease the neutron richness at the high temperatures predicted by the hydrodynamic simulation. Circumventing the complexities of modelling three-dimensional neutrino transport, (anti)neutrino captures are parametrized in terms of prescribed neutrino luminosities and mean energies, guided by published results and assumed as constant in time. Depending sensitively on the adopted νe-bar{ν }_e luminosity ratio, neutrino processes increase Ye to values between 0.25 and 0.40, still allowing for a successful r-process compatible with the observed solar abundance distribution and a significant fraction of the ejecta consisting of r-process nuclei. If the νe luminosities and mean energies are relatively large compared to the bar{ν }_e properties, the mean Ye might reach values >0.40 so that neutrino captures seriously compromise the success of the r-process. In this case, the r-abundances remain compatible with the solar distribution, but the total amount of ejected r-material is reduced to a few per cent, because the production of iron-peak elements is favoured. Proper neutrino physics, in particular also neutrino absorption, have to be included in BNSM simulations before final conclusions can be drawn concerning r-processing in this environment and concerning observational consequences like kilonovae, whose peak brightness and colour temperature are sensitive to the composition-dependent opacity of the ejecta.

    6. QUARK-NOVAE, COSMIC REIONIZATION, AND EARLY r-PROCESS ELEMENT PRODUCTION

      SciTech Connect

      Ouyed, Rachid; Pudritz, Ralph E.; Jaikumar, Prashanth

      2009-09-10

      We examine the case for quark-novae (QNe) as possible sources for the reionization and early metal enrichment of the universe. QNe are predicted to arise from the explosive collapse (and conversion) of sufficiently massive neutron stars into quark stars (QSs). A QN can occur over a range of timescales following the supernova (SN) event. For QNe that arise days to weeks after the SNe, we show that dual shock that arises as the QN ejecta encounter the SN ejecta can produce enough photons to reionize hydrogen in most of the intergalactic medium (IGM) by z {approx} 6. Such events can explain the large optical depth {tau} {sub e} {approx} 0.1 as measured by WMAP, if the clumping factor, C, of the material being ionized is smaller than 10. We suggest a way in which a normal initial mass function for the oldest stars can be reconciled with a large optical depth as well as the mean metallicity of the early IGM post reionization. We find that QN also make a contribution to r-process element abundances for atomic numbers A {>=} 130. We predict that the main cosmological signatures of QNe are the gamma-ray bursts that announce their birth. These will be clustered at redshifts in the range z {approx} 7-8 in our model.

    7. Beta-decay spectroscopy of r-process nuclei around N = 126

      NASA Astrophysics Data System (ADS)

      Hirayama, Y.; Miyatake, H.; Watanabe, Y. X.; Imai, N.; Ishiyama, H.; Jeong, S. C.; Jung, H. S.; Oyaizu, M.; Mukai, M.; Kimura, S.; Sonoda, T.; Wada, M.; Kim, Y. H.; Huyse, M.; Kudryavtsev, Yu.; Van Duppen, P.

      2016-02-01

      KEK Isotope Separation System (KISS) has been developed at RIKEN to study the β-decay properties of neutron-rich isotopes with neutron numbers around N = 126 to understand the astrophysical site of r-process. These nuclei will be produced by multi-nucleon transfer reactions in neutron-rich heavy ion collisions between 136Xe beam and 198Pt target. The KISS consists of an argon gas cell combined with a laser resonance ionization technique for atomic number selection, of an ISOL mass-separation system and of a detector system for the β-decay spectroscopy of nuclei around N = 126. The argon gas cell of KISS is a key component for thermalizing (stopping and neutralizing) and accumulating the unstable nuclei, and selectively ionizing them by using laser. We have performed off-and on-line experiments to study the basic properties of the gas cell as well as KISS. We successfully extracted the laser-ionized stable 198Pt atoms from the KISS at the commissioning on-line experiments. We furthermore extracted laser-ionized unstable 199Pt atoms and confirmed that the measured half-life was in good agreement with the reported value. Now KISS is ready for lifetime measurements of Pt, Ir, and Os isotopes around N = 126.

    8. Export Control Requirements for Tritium Processing Design and R&D

      SciTech Connect

      Hollis, William Kirk; Maynard, Sarah-Jane Wadsworth

      2015-10-30

      This document will address requirements of export control associated with tritium plant design and processes. Los Alamos National Laboratory has been working in the area of tritium plant system design and research and development (R&D) since the early 1970’s at the Tritium Systems Test Assembly (TSTA). This work has continued to the current date with projects associated with the ITER project and other Office of Science Fusion Energy Science (OS-FES) funded programs. ITER is currently the highest funding area for the DOE OS-FES. Although export control issues have been integrated into these projects in the past a general guidance document has not been available for reference in this area. To address concerns with currently funded tritium plant programs and assist future projects for FES, this document will identify the key reference documents and specific sections within related to tritium research. Guidance as to the application of these sections will be discussed with specific detail to publications and work with foreign nationals.

    9. DETECTION OF ELEMENTS AT ALL THREE r-PROCESS PEAKS IN THE METAL-POOR STAR HD 160617

      SciTech Connect

      Roederer, Ian U.; Lawler, James E. E-mail: jelawler@wisc.edu

      2012-05-01

      We report the first detection of elements at all three r-process peaks in the metal-poor halo star HD 160617. These elements include arsenic and selenium, which have not been detected previously in halo stars, and the elements tellurium, osmium, iridium, and platinum, which have been detected previously. Absorption lines of these elements are found in archive observations made with the Space Telescope Imaging Spectrograph on board the Hubble Space Telescope. We present up-to-date absolute atomic transition probabilities and complete line component patterns for these elements. Additional archival spectra of this star from several ground-based instruments allow us to derive abundances or upper limits of 45 elements in HD 160617, including 27 elements produced by neutron-capture reactions. The average abundances of the elements at the three r-process peaks are similar to the predicted solar system r-process residuals when scaled to the abundances in the rare earth element domain. This result for arsenic and selenium may be surprising in light of predictions that the production of the lightest r-process elements generally should be decoupled from the heavier r-process elements.

    10. Reactive oxygen species are involved in group I mGluR-mediated facilitation of nociceptive processing in amygdala neurons.

      PubMed

      Ji, Guangchen; Neugebauer, Volker

      2010-07-01

      Recent biochemical and behavioral data implicate reactive oxygen species (ROS) in peripheral and spinal pain mechanisms. However, pain-related functions of ROS in the brain and mechanisms of pain-related ROS activation remain to be determined. Our previous studies showed that the amygdala plays a key role in emotional-affective pain responses and pain modulation. Hyperactivity of amygdala neurons in an animal pain model depends on group I metabotropic glutamate receptors (subtypes mGluR1 and mGluR5), but their signaling pathway remains to be determined. Here we tested the hypothesis that activation of group I mGluRs increases nociceptive processing in amygdala neurons through a mechanism that involves ROS. Extracellular single-unit recordings were made from neurons in the laterocapsular division of the central nucleus of the amygdala (CeLC) in anesthetized adult male rats. Administration of a group I mGluR agonist (DHPG) into the CeLC by microdialysis increased the responses to innocuous and noxious somatosensory (knee joint compression) and visceral (colorectal distention [CRD]) stimuli. A ROS scavenger (PBN) and a superoxide dismutase mimetic (TEMPOL) reversed the facilitatory effects of DHPG. An mGluR5 antagonist (MPEP) also inhibited the effects of DHPG on the responses to innocuous and noxious somatosensory and visceral stimuli, whereas an mGluR1 antagonist (LY367385) decreased only the responses to visceral stimulation. The results show for the first time that ROS mediate group I mGluR-induced facilitation of nociceptive processing in amygdala neurons. The antagonist data may suggest differential contributions of subtypes mGluR1 and mGluR5 to the processing of somatosensory and visceral nociceptive information in the amygdala. PMID:20463194

    11. Reactive Oxygen Species Are Involved in Group I mGluR-Mediated Facilitation of Nociceptive Processing in Amygdala Neurons

      PubMed Central

      Ji, Guangchen

      2010-01-01

      Recent biochemical and behavioral data implicate reactive oxygen species (ROS) in peripheral and spinal pain mechanisms. However, pain-related functions of ROS in the brain and mechanisms of pain-related ROS activation remain to be determined. Our previous studies showed that the amygdala plays a key role in emotional-affective pain responses and pain modulation. Hyperactivity of amygdala neurons in an animal pain model depends on group I metabotropic glutamate receptors (subtypes mGluR1 and mGluR5), but their signaling pathway remains to be determined. Here we tested the hypothesis that activation of group I mGluRs increases nociceptive processing in amygdala neurons through a mechanism that involves ROS. Extracellular single-unit recordings were made from neurons in the laterocapsular division of the central nucleus of the amygdala (CeLC) in anesthetized adult male rats. Administration of a group I mGluR agonist (DHPG) into the CeLC by microdialysis increased the responses to innocuous and noxious somatosensory (knee joint compression) and visceral (colorectal distention [CRD]) stimuli. A ROS scavenger (PBN) and a superoxide dismutase mimetic (TEMPOL) reversed the facilitatory effects of DHPG. An mGluR5 antagonist (MPEP) also inhibited the effects of DHPG on the responses to innocuous and noxious somatosensory and visceral stimuli, whereas an mGluR1 antagonist (LY367385) decreased only the responses to visceral stimulation. The results show for the first time that ROS mediate group I mGluR-induced facilitation of nociceptive processing in amygdala neurons. The antagonist data may suggest differential contributions of subtypes mGluR1 and mGluR5 to the processing of somatosensory and visceral nociceptive information in the amygdala. PMID:20463194

    12. NEW RARE EARTH ELEMENT ABUNDANCE DISTRIBUTIONS FOR THE SUN AND FIVE r-PROCESS-RICH VERY METAL-POOR STARS

      SciTech Connect

      Sneden, Christopher; Lawler, James E.; Den Hartog, Elizabeth A.; Cowan, John J.; Ivans, Inese I. E-mail: jelawler@wisc.edu E-mail: cowan@nhn.ou.edu

      2009-05-15

      We have derived new abundances of the rare earth elements Pr, Dy, Tm, Yb, and Lu for the solar photosphere and for five very metal-poor, neutron-capture r-process-rich giant stars. The photospheric values for all five elements are in good agreement with meteoritic abundances. For the low-metallicity sample, these abundances have been combined with new Ce abundances from a companion paper, and reconsideration of a few other elements in individual stars, to produce internally consistent Ba, rare earth, and Hf (56 {<=} Z {<=} 72) element distributions. These have been used in a critical comparison between stellar and solar r-process abundance mixes.

    13. Current status and prospects of radiation processing studies in Taiwan, R. O. C.

      NASA Astrophysics Data System (ADS)

      Fu, Ying-Kai

      The research on radiation processing in past 5 years in Taiwan covers industrial application of radiation-induced polymerization and curing, medical application of radiosterilization of medical supplies, chemicals, and amniotic membrane for wound dressing as well as agricultural application of food irradiation and genogenesis etc. Radiation-induced polymerization applied on wood and bamboo plastic composite of methyl methacrylate, radiation curing on polyurethane and silicon rubber for biomedical material using to separate oxygen from nitrogen and on crosslinking of pp and ps for artificial skin for wound dressing were all success. Radio-sterilization of disposable medical supplies appears for immediate application after the studies of the dose requirement of several radioresistant microorganisms, dose distribution measured by chemical dosimeters of ceric sulfate and Fricke dosimeter as well as quality control system were completed. The radiosterilization study of tetracycline - HCl and few detoxic agents like atropine sulfate and toxogonin has shown the promising results on radiosterilization of chemicals, the radiosterilization of amniotic membrane for wound dressing are also success. Food irradiation on sprouting inhibition of potatoes, garlic etc, on radiodisinfestation of cereal insects, tobacco bettles, soybean insects, and flour beetles, as well as on frog legs and porks have been also discussed. The legislation on radiosterilization of medical supplies and food irradiation of 14 items has been approved by National Health Administration, R.O.C. in July of 1982 and January of 1985 respectively. Even 24 hrs-operation of 1 Mega curie irradiation plant at INER can not satisfy the requirement of radiosterilization of medical supplies. A private commercial irradiation plant is urgently needed in Taiwan other than at INER now.

    14. Electromagnetic counterparts of compact object mergers powered by the radioactive decay of r-process nuclei

      NASA Astrophysics Data System (ADS)

      Metzger, B. D.; Martínez-Pinedo, G.; Darbha, S.; Quataert, E.; Arcones, A.; Kasen, D.; Thomas, R.; Nugent, P.; Panov, I. V.; Zinner, N. T.

      2010-08-01

      The most promising astrophysical sources of kHz gravitational waves (GWs) are the inspiral and merger of binary neutron star(NS)/black hole systems. Maximizing the scientific return of a GW detection will require identifying a coincident electromagnetic (EM) counterpart. One of the most likely sources of isotropic EM emission from compact object mergers is a supernova-like transient powered by the radioactive decay of heavy elements synthesized in ejecta from the merger. We present the first calculations of the optical transients from compact object mergers that self-consistently determine the radioactive heating by means of a nuclear reaction network; using this heating rate, we model the light curve with a one-dimensional Monte Carlo radiation transfer calculation. For an ejecta mass ~10-2Msolar (10-3Msolar) the resulting light-curve peaks on a time-scale ~1d at a V-band luminosity νLν ~ 3 × 1041 (1041)ergs-1 [MV = -15(-14)] this corresponds to an effective `f' parameter ~3 × 10-6 in the Li-Paczynski toy model. We argue that these results are relatively insensitive to uncertainties in the relevant nuclear physics and to the precise early-time dynamics and ejecta composition. Since NS merger transients peak at a luminosity that is a factor of ~103 higher than a typical nova, we propose naming these events `kilo-novae'. Because of the rapid evolution and low luminosity of NS merger transients, EM counterpart searches triggered by GW detections will require close collaboration between the GW and astronomical communities. NS merger transients may also be detectable following a short-duration gamma-ray burst or `blindly' with present or upcoming optical transient surveys. Because the emission produced by NS merger ejecta is powered by the formation of rare r-process elements, current optical transient surveys can directly constrain the unknown origin of the heaviest elements in the Universe.

    15. R-chondrite bulk-chemical compositions and diverse oxides: Implications for parent-body processes

      NASA Astrophysics Data System (ADS)

      Isa, Junko; Rubin, Alan E.; Wasson, John T.

      2014-01-01

      R chondrites are among the most oxidized chondrite groups; they also have the highest Δ17O values known in whole-rock meteorites. We analyzed R chondrites (six Antarctic, four hot-desert) by instrumental neutron activation analysis. Data for one of the former and three of the latter show large weathering effects, but the remainder show only moderate scatter and permit us to determine trends and mean compositions for the group. Bulk R-chondrite compositions are similar to those in H and L chondrites, but the concentrations of several volatiles, especially Se and Zn, are higher; the more volatile the element, the higher the enrichment in R chondrites relative to H and L. Petrologic types in R chondrites extend as low as 3.6. We determined olivine compositional distributions and studied opaque oxides in 15 R-chondrite thin sections, including a newly discovered R4 clast in Bencubbin (adding to the diversity of chondritic clasts in this polymict breccia) and an R clast in CM2 Murchison. Opaque oxides in R chondrites include nearly pure magnetite, Al-rich chromite, magnetite-chromite solid solution, nearly pure chromite, and ilmenite. This diverse set of opaque phases reflects differing aqueous-alteration conditions. The least equilibrated R chondrites contain nearly pure magnetite but the spinels in metamorphosed R chondrites contain additional components (e.g., Cr2O3 and Al2O3 and some minor cations). The NiO content in olivine correlates with the magnetite component in magnetite-chromite solid solution in equilibrated R chondrites and is a function of the degree of oxidation. The absence of metallic Fe in A-881988 and LAP 031156 indicates a high degree of oxidation; the relatively low-FeO (Fa35) olivine in these rocks in part reflects the conversion of Fe2+ to Fe3+ and its partitioning into magnetite. Oxidation trends in R chondrites are affected by both aqueous alteration and thermal metamorphism. The differing degrees of oxidation in this group reflect differences in local environments on the parent asteroid.

    16. The membrane-biofilm reactor (MBfR) as a counter-diffusional biofilm process.

      PubMed

      Nerenberg, Robert

      2016-04-01

      The membrane-biofilm reactor (MBfR), sometimes known as the membrane-aerated biofilm reactor (MABR), is an emerging treatment technology based on gas-transferring membranes. The membranes typically supply a gaseous electron donor or acceptor substrate, such as oxygen, hydrogen, and methane. The substrate diffuses through the membrane to a biofilm naturally forming on the membrane outer surface. The complementary substrate (electron donor or acceptor) typically diffuses from the bulk liquid into the biofilm, making MBfR counter diffusional. This paper reviews the unique behavior of counter-diffusional biofilms and highlights recent research on the MBfR. Key advances include insights into the microbial community structure of MBfRs, applying the MBfR to novel contaminants, providing a better understanding of biofilm morphology and its effects on MBfR behavior, and the development of methane-based MBfR applications. These advances are likely to further the development of the MBfR for environmental applications, such as energy-efficient wastewater treatment and advanced water treatment. PMID:26874609

    17. Effects of charge transfer on the ESIPT process in methyl 5-R-salicylates.

      PubMed

      Catalán, J

      2015-02-12

      The fluorescent behavior of the methyl-5-R-salicylates is analyzed in media of negligible acidity and basicity so that the methyl-5-R-salicylates may undergo solvent dipolarity changes or not in a controlled manner based on the following guidelines: (i) The molecular forms of these methyl-5-R-salicylates possessing an intramolecular hydrogen bond (IMHB) between their hydroxyl group and ether type oxygen (rotated tautomer) undergo no excited-state intramolecular proton transfer (ESIPT) in their first excited electronic state; (ii) on the other hand, the molecular species with an IMHB between its hydroxyl group and carbonyl oxygen (normal tautomer) exhibits both ESIPT and normal emission when charge transfer (CT) from the R-substituent to the phenol group is slight to moderate, but only normal emission is monitored when CT is strong. The special insensitivity of the first UV absorption band for the normal tautomer of methylsalicylate (MS, with R = H) to the polarity of the solvent is not echoed by the normal forms of methyl-5-R-salicylates containing substituents R with a substantial effect of CT in the IMHB of the compound. These solvatochromic features of MS are shared by the emissions of its derivatives. The photophysical evidence found for the methyl-5-R-salicylates confirms the photophysical model recently reported (Phys. Chem. Chem. Phys. 2012, 14, 8903-8909), which assigns three fluorescent emissions to the methyl-5-R-salicylates: two of them coming from the IMHB normal tautomer, which undergoes ESIPT, and another from the IMHB rotated tautomer, which cannot undergo ESIPT. PMID:24967729

    18. Chemo-dynamical evolution model: Enrichment of r-process elements in the Local Group dwarf galaxies

      NASA Astrophysics Data System (ADS)

      Hirai, Yutaka; Ishimaru, Yuhri; Saitoh, Takayuki R.; Fujii, Michiko S.; Hidaka, Jun; Kajino, Toshitaka

      2015-08-01

      Enrichment of the r-process elements is expected to provide a critical clue to understand the formation history of galactic halos. Recent astronomical high dispersion observations of metal-poor stars have shown large dispersions in relative abundance ratios of r-process elements such as [Eu/Fe] in stars with [Fe/H] < -2.5. Astrophysical site(s) of r-process has, however, not been identified yet. Promising site(s) of r-process are core-collapse supernovae (CCSNe) and neutron-star mergers (NSMs). Recent nucleosynthesis studies have shown that r-process elements heavier than 110 of mass number are difficult to synthesize by CCSNe. On the other hand, several studies reported that NSMs can synthesize these elements due to their environment of low electron fraction. Previous chemical evolution model (e.g., Argast et al. 2004) of the Milky Way (MW) halo without dynamical evolution pointed out that the NSMs are difficult to reproduce observed dispersion in [Eu/Fe] vs. [Fe/H] due to their low rate 10-6 - 10-3 yr-1 for a MW size galaxy and the long delay time, t ≥ 100 Myr. In the present study, we carry out numerical simulations of galactic chemo-dynamical evolution using an N-body/smoothed particle hydrodynamics code, ASURA. We construct detailed chemo-dynamical evolution model for dwarf spheroidal galaxies (dSphs) assuming that the NSMs are the major source of the r-process elements. Our models successfully reproduce the observed dispersion in [Eu/Fe] vs. [Fe/H] if we set t < 500 Myr with the Galactic NSM rate ~10-4 yr-1. Moreover, our results are consistent with observed metallicity distribution and mass-metallicity relation of dSphs. We then find that the effects of gas mixing processes including metals in the star-forming region of a typical scale of giant molecular clouds ~ 10 - 100 pc play the significant roles in reproducing the measured dispersion in [Eu/Fe] vs. [Fe/H] of the metal-poor stars in dSphs. We also find that the star formation rate of ~ 10-3 M⊙yr-1 in early epoch (< 1 Gyr) of galactic halo evolution is necessary for this results. This study strongly supports that NSM is a major site of r-process.

    19. The Human Nucleolar Protein FTSJ3 Associates with NIP7 and Functions in Pre-rRNA Processing

      PubMed Central

      Morello, Luis G.; Coltri, Patricia P.; Quaresma, Alexandre J. C.; Simabuco, Fernando M.; Silva, Tereza C. L.; Singh, Guramrit; Nickerson, Jeffrey A.; Oliveira, Carla C.; Moore, Melissa J.; Zanchin, Nilson I. T.

      2011-01-01

      NIP7 is one of the many trans-acting factors required for eukaryotic ribosome biogenesis, which interacts with nascent pre-ribosomal particles and dissociates as they complete maturation and are exported to the cytoplasm. By using conditional knockdown, we have shown previously that yeast Nip7p is required primarily for 60S subunit synthesis while human NIP7 is involved in the biogenesis of 40S subunit. This raised the possibility that human NIP7 interacts with a different set of proteins as compared to the yeast protein. By using the yeast two-hybrid system we identified FTSJ3, a putative ortholog of yeast Spb1p, as a human NIP7-interacting protein. A functional association between NIP7 and FTSJ3 is further supported by colocalization and coimmunoprecipitation analyses. Conditional knockdown revealed that depletion of FTSJ3 affects cell proliferation and causes pre-rRNA processing defects. The major pre-rRNA processing defect involves accumulation of the 34S pre-rRNA encompassing from site A′ to site 2b. Accumulation of this pre-rRNA indicates that processing of sites A0, 1 and 2 are slower in cells depleted of FTSJ3 and implicates FTSJ3 in the pathway leading to 18S rRNA maturation as observed previously for NIP7. The results presented in this work indicate a close functional interaction between NIP7 and FTSJ3 during pre-rRNA processing and show that FTSJ3 participates in ribosome synthesis in human cells. PMID:22195017

    20. A Study on the Application of Fuzzy Analytic Hierarchy Process to Construct an R and D Management Effectiveness Evaluation Index for Taiwan=s High-Tech Industry

      NASA Astrophysics Data System (ADS)

      Liu, Pang-Lo; Tsai, Chih-Hung

      The high-tech industry is one of the most important links in Taiwan=s economic development. Research and Development (R and D) technology and management is the key to sustainable enterprises. However, the involvement of many difficult quantification factors and the fuzzy character of human subjective judgment on the R and D management content and process makes R and D management effectiveness evaluation more difficult. This study adopted the Fuzzy Analytic Hierarchy Process (FAHP) from the Fuzzy Theory to develop a set of systematized evaluation indices for R and D management effectiveness. This method is designed to assist enterprises in conducting R and D management effectiveness evaluations to achieve the goal increasing enterprise competitiveness. According to the outcome of this study, the researchers found the importance and weight of these major aspects for Taiwan=s high-tech industry=s R and D management effectiveness is shown as follows: R and D and Innovation (0.346), R and D Process (0.269), Customer (0.209) and R and D Personnel (0.184). Moreover, among the effectiveness evaluations on implementing the R and D management in certain industries, R and D and Innovation and R and D Process are determined as the important item that revealed how Taiwan=s high-tech industries are particular about achieving R and D management through the completed R and D and innovation process.

    1. The Role of Fission in Neutron Star Mergers and Its Impact on the r-Process Peaks

      NASA Astrophysics Data System (ADS)

      Eichler, M.; Arcones, A.; Kelic, A.; Korobkin, O.; Langanke, K.; Marketin, T.; Martinez-Pinedo, G.; Panov, I.; Rauscher, T.; Rosswog, S.; Winteler, C.; Zinner, N. T.; Thielemann, F.-K.

      2015-07-01

      Comparing observational abundance features with nucleosynthesis predictions of stellar evolution or explosion simulations, we can scrutinize two aspects: (a) the conditions in the astrophysical production site and (b) the quality of the nuclear physics input utilized. We test the abundance features of r-process nucleosynthesis calculations for the dynamical ejecta of neutron star merger simulations based on three different nuclear mass models: The Finite Range Droplet Model, the (quenched version of the) Extended Thomas Fermi Model with Strutinsky Integral, and the Hartree-Fock-Bogoliubov mass model. We make use of corresponding fission barrier heights and compare the impact of four different fission fragment distribution models on the final r-process abundance distribution. In particular, we explore the abundance distribution in the second r-process peak and the rare-earth sub-peak as a function of mass models and fission fragment distributions, as well as the origin of a shift in the third r-process peak position. The latter has been noticed in a number of merger nucleosynthesis predictions. We show that the shift occurs during the r-process freeze-out when neutron captures and β-decays compete and an (n,γ)-(γ,n) equilibrium is no longer maintained. During this phase neutrons originate mainly from fission of material above A = 240. We also investigate the role of β-decay half-lives from recent theoretical advances, which lead either to a smaller amount of fissioning nuclei during freeze-out or a faster (and thus earlier) release of fission neutrons, which can (partially) prevent this shift and has an impact on the second and rare-earth peak as well.

    2. Compact Stellar Binary Assembly in the First Nuclear Star Clusters and r-process Synthesis in the Early Universe

      NASA Astrophysics Data System (ADS)

      Ramirez-Ruiz, Enrico; Trenti, Michele; MacLeod, Morgan; Roberts, Luke F.; Lee, William H.; Saladino-Rosas, Martha I.

      2015-04-01

      Investigations of elemental abundances in the ancient and most metal deficient stars are extremely important because they serve as tests of variable nucleosynthesis pathways and can provide critical inferences of the type of stars that lived and died before them. The presence of r-process elements in a handful of carbon-enhanced metal-poor (CEMP-r) stars, which are assumed to be closely connected to the chemical yield from the first stars, is hard to reconcile with standard neutron star mergers. Here we show that the production rate of dynamically assembled compact binaries in high-z nuclear star clusters can attain a sufficient high value to be a potential viable source of heavy r-process material in CEMP-r stars. The predicted frequency of such events in the early Galaxy, much lower than the frequency of Type II supernovae but with significantly higher mass ejected per event, can naturally lead to a high level of scatter of Eu as observed in CEMP-r stars.

    3. Rolling Deck to Repository (R2R): Programmatic Quality Assessment and Processing of Marine Gravity and Magnetic Data and Associated Metadata

      NASA Astrophysics Data System (ADS)

      Morton, J. J.; Ferrini, V.; O'hara, S. H.; Arko, R. A.; Carbotte, S. M.; Coakley, B.

      2011-12-01

      With its global capability and diverse array of sensors, the U.S. academic research fleet is an integral component of ocean exploration. The Rolling Deck to Repository (R2R) Program provides a central shore-side gateway for underway data from the U.S. academic research fleet, with the primary goal of preserving and documenting routine underway data. Programmatic tools for Quality Assessment (QA) of multiple underway data types are being developed to provide prompt feedback to shipboard operators and inform down-stream science users. QA tools are being developed in object oriented PHP with modular components that can be distributed for use by the community. Programmatic data processing (DP) tools for select data types are also being developed. We report on recent progress with QA and DP tools developed for underway gravity and magnetics data. For magnetics data, DP includes despiking and removal of bad data, merging with navigation, turn removal, calculation of a layback position, and removal of the IGRF to produce a magnetic anomaly. For gravity data, DP involves merging with navigation, corrections for speed and heading (Eötvös) and latitude, some basic filtering, removing bad data, subsampling, and drift corrections. All of these tools follow a programmatic workflow that requires minimal human intervention. Advanced processing which requires human intervention is left to the science user. These tools make use of metadata specific to each device and data type, as well as customizable thresholds and processing parameters. The full suite of metadata that describes each data set, the quality assessment parameters and results, as well as processing steps will accompany the data being submitted to the National Geophysical Data Center. In addition to QA reports for raw data files, day plots are also produced at each step to allow for quick observation and verification of the data quality and processing steps. These plots will also be delivered with the data files. The result of data processing for gravity and magnetics data is a quality assessed multiplexed file (MGD77T). In addition, web tools are being developed to provide science users and operators with a quick and intuitive interface for reviewing QA results.

    4. Abundances of r-PROCESS Elements in the Photosphere of Red Supergiant Star PMMR23 in Small Magellanic Cloud

      NASA Astrophysics Data System (ADS)

      Vasil'Eva, S. V.; Gopka, V. F.; Yushchenko, A. V.; Andryevsky, S. M.

      Detailed analysis of chemical abundances determined from high-resolution CCD-spectrogram of supergiant star PMMR23 (K5 I) in SMC is presented. The observation were obtained at 3.6 meter ESO La Silla telescope by Hill (1997). Spectral resolving power is near R=30.000. The wavelength coverage is 5050-7200 A. The abundances of iron and 15 r-, s-processes elements are found. The abundances of Cu, Zr, Mo, Ru, Pr, Sm, Gd, Dy, Er are found for the first time. The abundances of elements with atomic numbers less than 55 are deficient with respect to the Sun. The mean underabundance is near 0.7 dex. The abundances of barium and lanthanides are near solar values. The overabundances of these elements with respect to iron are in the range from 0.4 tp 0.9 dex. The abundances of heavy lanthanides are higher than the abundances of light lanthanides. The abundance pattern of PMMR23 can be fitted by scaled solar r-process distribution. The atmosphere of PMMR23 is enriched by r-process elements.

    5. Mutation of R555 in CFTR-delta F508 enhances function and partially corrects defective processing.

      PubMed

      Teem, J L; Carson, M R; Welsh, M J

      1996-01-01

      The most common cystic fibrosis mutation deletes phenylalanine 508 in CFTR (CFTR-F508). This mutation causes the loss of CFTR Cl- channel activity by disrupting biosynthetic processing so that mutant protein does not reach the plasma membrane. It also decreases the rate at which mutant channels open. To identify second-site mutations that could reverse the effects of delta F508, we used a chimeric yeast STE6/CFTR system bearing the delta F508 mutation. This chimera manifests defective mating. After mutagenesis of the first nucleotide-binding domain, we found that mutation R555K partially restored mating. However, it also increased mating in the chimera lacking the delta F508 mutation. When we introduced the R555K mutation into human CFTR-delta F508, we found that the loss of apical Cl- current caused by delta F508 was partially restored, predominantly due to a partial correction of the delta F508 processing defect. Analysis of single CFTR Cl- channels showed that the R555K mutation did not correct the prolonged closed time associated with delta F508, rather it increased activity of both wild-type and delta F508 channels by prolonging the duration of bursts of activity. These data suggest that the region around residue R555 in the first nucleotide-binding domain is important both in determining the ability of the delta F508 protein to be properly processed and in determining channel function. PMID:8723647

    6. Near-Ultraviolet Observations of HD 221170: New Insights into the Nature of r-Process-rich Stars

      NASA Astrophysics Data System (ADS)

      Ivans, Inese I.; Simmerer, Jennifer; Sneden, Christopher; Lawler, James E.; Cowan, John J.; Gallino, Roberto; Bisterzo, Sara

      2006-07-01

      Employing high-resolution spectra obtained with the near-UV-sensitive detector on the Keck I HIRES, supplemented by data obtained with the McDonald Observatory 2d-coudé, we have performed a comprehensive chemical composition analysis of the bright r-process-rich metal-poor red giant star HD 221170. Analysis of 57 individual neutral and ionized species yielded abundances for a total of 46 elements and significant upper limits for an additional five. Model stellar atmosphere parameters were derived with the aid of ~200 Fe peak transitions. From more than 350 transitions of 35 neutron-capture (Z>30) species, abundances for 30 neutron-capture elements and upper limits for three others were derived. Utilizing 36 transitions of La, 16 of Eu, and seven of Th, we derive ratios of logɛ(Th/La)=-0.73 (σ=0.06) and logɛ(Th/Eu)=-0.60 (σ=0.05), values in excellent agreement with those previously derived for other r-process-rich metal-poor stars such as CS 22892-052, BD +17 3248, and HD 115444. Based on the Th/Eu chronometer, the inferred age is 11.7+/-2.8 Gyr. The abundance distribution of the heavier neutron-capture elements (Z>=56) is fitted well by the predicted scaled solar system r-process abundances, as also seen in other r-process-rich stars. Unlike other r-process-rich stars, however, we find that the abundances of the lighter neutron-capture elements (37r-process pattern. Some of the data presented herein were obtained at the W. M. Keck Observatory, which is operated as a scientific partnership among the California Institute of Technology, University of California, and NASA and was made possible by the financial support of the W. M. Keck Foundation. This paper includes data taken at the McDonald Observatory of the University of Texas at Austin.

    7. R&D for the Post-EP Processes of Superconducting RF Cavity

      SciTech Connect

      Saeki, Takayuki; Funahashi, Y.; Hayano, H.; Kato, Seigo; Nishiwaki, Michiru; Sawabe, Motoaki; Ueno, Kenji; Watanabe, K.; Antoine, Claire; Berry, Stefurn; Eozenou, F.; Gasser, Y.; Visentin, B.; Clemens, William A.; Geng, Rongli; Manus, Robert; Tyagi, Puneet

      2009-11-01

      The Electro-Polishing (EP) process is the best candidate of final surface treatment for the production of ILC cavities. Nevertheless, the broad distribution of the gradient caused by field emitters in cavities is sitll a serious problem for the EP process. A candidate source of field emitter is the sulfur component which is produced in the EP process and remains the inner-surface of cavities. We studied the effect of Ethanole- and degreaser-rinse processes after the EP process by a unique method. Moreover, we tried to test the sponge cleaning as the post-EP process to remove the field emitter inside the cavcity. This article describe the results of series tests of the post-EP process at KEK.

    8. Study on rheo-diecasting process of 7075R alloys by SA-EMS melt homogenized treatment

      NASA Astrophysics Data System (ADS)

      Zhihua, G.; Jun, X.; Zhifeng, Z.; Guojun, L.; Mengou, T.

      2016-03-01

      An advanced melt processing technology, spiral annular electromagnetic stirring (SA-EMS) based on the annular electromagnetic stirring (A-EMS) process was developed for manufacturing Al-alloy components with high integrity. The SA-EMS process innovatively combines non-contact electromagnetic stirring and a spiral annular chamber with specially designed profiles to in situ make high quality melt slurry, and intensive forced shearing can be achieved under high shear rate and high intensity of turbulence inside the spiral annular chamber. In this paper, the solidification microstructure and hardness of 7075R alloy die-casting connecting rod conditioned by the SA-EMS melt processing technology were investigated. The results indicate that, the SA-EMS melt processing technology exhibited superior grain refinement and remarkable structure homogeneity. In addition, it can evidently enhance the mechanical performance and reduce the crack tendency.

    9. Inhibitory repetitive transcranial magnetic stimulation (rTMS) of the dorsolateral prefrontal cortex modulates early affective processing.

      PubMed

      Zwanzger, Peter; Steinberg, Christian; Rehbein, Maimu Alissa; Bröckelmann, Ann-Kathrin; Dobel, Christian; Zavorotnyy, Maxim; Domschke, Katharina; Junghöfer, Markus

      2014-11-01

      The dorsolateral prefrontal cortex (dlPFC) has often been suggested as a key modulator of emotional stimulus appraisal and regulation. Therefore, in clinical trials, it is one of the most frequently targeted regions for non-invasive brain stimulation such as repetitive transcranial magnetic stimulation (rTMS). In spite of various encouraging reports that demonstrate beneficial effects of rTMS in anxiety disorders, psychophysiological studies exploring the underlying neural mechanisms are sparse. Here we investigated how inhibitory rTMS influences early affective processing when applied over the right dlPFC. Before and after rTMS or sham stimulation, subjects viewed faces with fearful or neutral expressions while whole-head magnetoencephalography (MEG) was recorded. Due to the disrupted functioning of the right dlPFC, visual processing in bilateral parietal, temporal, and occipital areas was amplified starting at around 90 ms after stimulus onset. Moreover, increased fear-specific activation was found in the right TPJ area in a time-interval between 110 and 170 ms. These neurophysiological effects were reflected in slowed reaction times for fearful, but not for neutral faces in a facial expression identification task while there was no such effect on a gender discrimination control task. Our study confirms the specific and important role of the dlPFC in regulation of early emotional attention and encourages future clinical research to use minimal invasive methods such as transcranial magnetic (TMS) or direct current stimulation (tDCS). PMID:25019678

    10. Explosive Nucleosynthesis in Magnetohydrodynamical Jets from Collapsars. II --- Heavy-Element Nucleosynthesis of s, p, r-Processes

      NASA Astrophysics Data System (ADS)

      Ono, M.; Hashimoto, M.; Fujimoto, S.; Kotake, K.; Yamada, S.

      2012-10-01

      We investigate the nucleosynthesis in a massive star of 70 M_{⊙} with solar metallicity in the main sequence stage. The helium core mass after hydrogen burning corresponds to 32 M_{⊙}. Nucleosynthesis calculations have been performed during the stellar evolution and the jetlike supernova explosion of a collapsar model. We focus on the production of elements heavier than iron group nuclei. Nucleosynthesis calculations have been accomplished consistently from hydrostatic to dynamic stages by using large nuclear reaction networks, where the weak s-, p-, and r-processes are taken into account. We confirm that s-elements of 60 < A < 90 are highly overproduced relative to the solar abundances in the hydrostatic nucleosynthesis. During oxygen burning, p-elements of A > 90 are produced via photodisintegrations of seed s-elements. However, the produced p-elements are disintegrated in later stages except for ^{180}Ta. In the explosive nucleosynthesis, elements of 90 < A < 160 are significantly overproduced relative to the solar values owing to the r-process, which is very different from the results of spherical explosion models. Only heavy p-elements (N > 50) are overproduced via the p-process because of the low peak temperatures in the oxygen- and neon-rich layers. Compared with the previous study of r-process nucleosynthesis calculations in the collapsar model of 40 M_{⊙} by Fujimoto et al. [S. Fujimoto, M. Hashimoto, K. Kotake and S. Yamada, Astrophys. J. 656 (2007), 382; S. Fujimoto, N. Nishimura and M. Hashimoto, Astrophys. J. 680 (2008), 1350], our jet model cannot contribute to the third peak of the solar r-elements and intermediate p-elements, which have been much produced because of the distribution of the lowest part of electron fraction in the ejecta. Averaging the overproduction factors over the progenitor masses with the use of Salpeter's IMF, we suggest that the 70 M_{⊙} star could contribute to the solar weak s}-elements of 60 < A < 90 and neutron-rich elements of 90 < A < 160. We confirm the primary synthesis of light p-elements in the ejected matter of high peak temperature. The ejected matter has [Sr/Eu] ˜ -0.4, which is different from that of a typical r-process-enriched star CS22892-052 ([Sr/Eu] ˜ -1). We find that Sr-Y-Zr isotopes are primarily synthesized in the explosive nucleosynthesis in a similar process of the primary production of light p-elements, which has been considered as one of the sites of a lighter element primary process (LEPP).

    11. Impact of the first-forbidden β decay on the production of A ∼ 195 r-process peak

      NASA Astrophysics Data System (ADS)

      Nishimura, Nobuya; Podolyák, Zsolt; Fang, Dong-Liang; Suzuki, Toshio

      2016-05-01

      We investigated the effects of first-forbidden transitions in β decays on the production of the r-process A ∼ 195 peak. The theoretical calculated β-decay rates with β-delayed neutron emission were examined using several astrophysical conditions. As the FF decay is dominant in N ∼ 126 neutron-rich nuclei, their inclusion shortens β-decay lifetimes and shifts the abundance peak towards higher masses. Additionally, the inclusion of the β-delayed neutron emission results in a wider abundance peak, and smoothens the mass distribution by removing the odd-even mass staggering. The effects are commonly seen in the results of all adopted astrophysical models. Nevertheless there are quantitative differences, indicating that remaining uncertainty in the determination of half-lives for N = 126 nuclei is still significant in order to determine the production of the r-process peak.

    12. Search for spin-orbit-force reduction at {sup 106,108}Zr around r-process path

      SciTech Connect

      Sumikama, T.; Yoshinaga, K.; Watanabe, H.; and others

      2012-11-12

      Shell gap at the magic number N= 82 is important to reproduce the 2nd peak of r-process abundance. If a spin-orbit force is reduced in a very neutron-rich region, a shell quenching at N= 82 and a new shell closure at N70 are predicted. A shell evolution by the spin-orbit-force reduction can be searched for through the shape evolution of Zr isotopes around an expected double magic nuclei, {sup 110}Zr(Z = 40,N = 70). We performed {beta}-{gamma} and isomer spectroscopy at RIBF to observe low-lying states in {sup 106,108}Zr. The present results indicate a well deformed shape for {sup 106,108}Zr. The drastic reduction of the spin-orbit force most likely does not occur around {sup 110}Zr on an r-process path.

    13. Uranium lines in the spectra of peculiar A stars - A search for recent r-process events

      NASA Technical Reports Server (NTRS)

      Cowley, C. R.; Adelman, S. J.

      1975-01-01

      Uranium wavelengths in the spectra of Ap stars are studied to see if they give any indication of a recent r-process event. It is concluded that there is no credible evidence for an admixture of uranium-235 in these stars, which would imply such an event. The evidence, though negative, is badly confused by blending of lines, and a final judgement must wait for an observational clarification of the situation.

    14. A two-step enzymatic resolution process for large-scale production of (S)- and (R)-ethyl-3-hydroxybutyrate.

      PubMed

      Fishman, A; Eroshov, M; Dee-Noor, S S; van Mil, J; Cogan, U; Effenberger, R

      2001-08-01

      An efficient two-step enzymatic process for production of (R)- and (S)-ethyl-3-hydroxybutyrate (HEB), two important chiral intermediates for the pharmaceutical market, was developed and scaled-up to a multikilogram scale. Both enantiomers were obtained at 99% chemical purity and over 96% enantiomeric excess, with a total process yield of 73%. The first reaction involved a solvent-free acetylation of racemic HEB with vinylacetate for the production of (S)-HEB. In the second reaction, (R)-enriched ethyl-3-acetoxybutyrate (AEB) was subjected to alcoholysis with ethanol to derive optically pure (R)-HEB. Immobilized Candida antarctica lipase B (CALB) was employed in both stages, with high productivity and selectivity. The type of butyric acid ester influenced the enantioselectivity of the enzyme. Thus, extending the ester alkyl chain from ethyl to octyl resulted in a decrease in enantiomeric excess, whereas using bulky groups such as benzyl or t-butyl, improved the enantioselectivity of the enzyme. A stirred reactor was found unsuitable for large-scale production due to attrition of the enzyme particles and, therefore, a batchwise loop reactor system was used for bench-scale production. The immobilized enzyme was confined to a column and the reactants were circulated through the enzyme bed until the targeted conversion was reached. The desired products were separated from the reaction mixture in each of the two stages by fractional distillation. The main features of the process are the exclusion of solvent (thus ensuring high process throughput), and the use of the same enzyme for both the acetylation and the alcoholysis steps. Kilogram quantities of (S)-HEB and (R)-HEB were effectively prepared using this unit, which can be easily scaled-up to produce industrial quantities. PMID:11400099

    15. PRETREATMENT AND FRACTIONATION OF CORN STOVER BY AMMONIA RECYCLE PERCOLATION PROCESS. (R831645)

      EPA Science Inventory

      Corn stover was pretreated with aqueous ammonia in a flow-through column reactor,
      a process termed as Ammonia Recycle Percolation (ARP). The aqueous ammonia causes
      swelling and efficient delignification of biomass at high temperatures. The ARP
      process solubilizes abou...

    16. Probing the Site for r-Process Nucleosynthesis with Abundances of Barium and Magnesium in Extremely Metal-poor Stars.

      PubMed

      Tsujimoto; Shigeyama; Yoshii

      2000-03-01

      We suggest that if the astrophysical site for r-process nucleosynthesis in the early Galaxy is confined to a narrow mass range of Type II supernova (SN II) progenitors, with a lower mass limit of Mms=20 M middle dot in circle, a unique feature in the observed distribution of [Ba/Mg] versus [Mg/H] for extremely metal-poor stars can be adequately reproduced. We associate this feature, a bifurcation of the observed elemental ratios into two branches in the Mg abundance interval -3.7processes. The first branch, which we call the y-branch, is associated with the production of Ba and Mg from individual massive supernovae. The derived mass of Ba synthesized in SNe II is 8.5x10-6 M middle dot in circle for Mms=20 M middle dot in circle and 4.5x10-8 M middle dot in circle for Mms=25 M middle dot in circle. We conclude that SNe II with Mms approximately 20 M middle dot in circle are the dominant source of r-process nucleosynthesis in the early Galaxy. An SN-induced chemical evolution model with this Mms-dependent Ba yield creates the y-branch, reflecting the different nucleosynthesis yields of [Ba/Mg] for each SN II with Mms greater, similar20 M middle dot in circle. The second branch, which we call the i-branch, is associated with the elemental abundance ratios of stars which were formed in the dense shells of the interstellar medium swept up by SNe II with Mms<20 M middle dot in circle that do not synthesize r-process elements, and it applies to stars with observed Mg abundances in the range &sqbl0;Mg&solm0;H&sqbr0;<-2.7. The Ba abundances in these stars reflect those of the interstellar gas at the (later) time of their formation. The existence of a [Ba/Mg] i-branch strongly suggests that SNe II that are associated with stars of progenitor mass Mmsr-process elements. We predict the existence of this i-branch for other r-process elements, such as europium (Eu), to the extent that their production site is in common with Ba. PMID:10673408

    17. NEW ABUNDANCE DETERMINATIONS OF CADMIUM, LUTETIUM, AND OSMIUM IN THE r-PROCESS ENRICHED STAR BD +17 3248 {sup ,}

      SciTech Connect

      Roederer, Ian U.; Sneden, Christopher; Lawler, James E.; Cowan, John J.

      2010-05-01

      We report the detection of Cd I (Z = 48), Lu II (Z = 71), and Os II (Z = 76) in the metal-poor star BD +17 3248. These abundances are derived from an ultraviolet spectrum obtained with the Space Telescope Imaging Spectrograph on the Hubble Space Telescope. This is the first detection of these neutron-capture species in a metal-poor star enriched by the r process. We supplement these measurements with new abundances of Mo I, Ru I, and Rh I derived from an optical spectrum obtained with the High Resolution Echelle Spectrograph on Keck. Combined with previous abundance derivations, 32 neutron-capture elements have been detected in BD +17 3248, the most complete neutron-capture abundance pattern in any metal-poor star to date. The light neutron-capture elements (38 {<=} Z {<=} 48) show a more pronounced even-odd effect than expected from current solar system r-process abundance predictions. The age for BD +17 3248 derived from the Th II/Os II chronometer is in better agreement with the age derived from other chronometers than the age derived from Th II/Os I. New Hf II abundance derivations from transitions in the ultraviolet are lower than those derived from transitions in the optical, and the lower Hf abundance is in better agreement with the scaled solar system r-process distribution.

    18. On the role of the supramarginal gyrus in phonological processing and verbal working memory: evidence from rTMS studies.

      PubMed

      Deschamps, Isabelle; Baum, Shari R; Gracco, Vincent L

      2014-01-01

      The supramarginal gyrus (SMG) is activated for phonological processing during both language and verbal working memory tasks. Using rTMS, we investigated whether the contribution of the SMG to phonological processing is domain specific (specific to phonology) or more domain general (specific to verbal working memory). A measure of phonological complexity was developed based on sonority differences and subjects were tested after low frequency rTMS on a same/different judgment task and an n-back verbal memory task. It was reasoned that if the phonological processing in the SMG is more domain general, i.e., related to verbal working memory demands, performance would be more affected by the rTMS during the n-back task than during the same/different judgment task. Two auditory experiments were conducted. The first experiment demonstrated that under conditions where working memory demands are minimized (i.e. same/different judgment), repetitive stimulation had no effect on performance although performance varied as a function of phonological complexity. The second experiment demonstrated that during a verbal working memory task (n-back task), where phonological complexity was also manipulated, subjects were less accurate and slower at performing the task after stimulation but the effect of phonology was not affected. The results confirm that the SMG is involved in verbal working memory but not in the encoding of sonority differences. PMID:24184438

    19. Discovery of a strongly r-process enhanced extremely metal-poor star LAMOST J110901.22+075441.8

      NASA Astrophysics Data System (ADS)

      Li, Hai-Ning; Aoki, Wako; Honda, Satoshi; Zhao, Gang; Christlieb, Norbert; Suda, Takuma

      2015-08-01

      We report the discovery of an extremely metal-poor (EMP) giant, LAMOST J110901.22+075441.8, which exhibits a large excess of r-process elements with [Eu/Fe] ˜ +1.16. The star is one of the newly discovered EMP stars identified from the LAMOST low-resolution spectroscopic survey and a high-resolution follow-up observation with the Subaru Telescope. Stellar parameters and elemental abundances have been determined from the Subaru spectrum. Accurate abundances for a total of 23 elements including 11 neutron-capture elements from Sr through Dy have been derived for LAMOST J110901.22+075441.8. The abundance pattern of LAMOST J110901.22+075441.8 in the range of C through Zn is in line with the “normal” population of EMP halo stars, except that it shows a notable underabundance in carbon. The heavy element abundance pattern of LAMOST J110901.22+075441.8 is in agreement with other well studied cool r-II metal-poor giants such as CS 22892-052 and CS 31082-001. The abundances of elements in the range from Ba through Dy match the scaled solar r-process pattern well. LAMOST J110901.22+075441.8 provides the first detailed measurements of neutron-capture elements among r-II stars at such low metallicity with [Fe/H] ≲ -3.4, and exhibits similar behavior as other r-II stars in the abundance ratio of Zr/Eu as well as Sr/Eu and Ba/Eu.

    20. Hydrogen Technology Validation as a "Learning Demonstration" that Feeds the R&D Process (Presentation)

      SciTech Connect

      Wipke, K.; Gronich, S.; Hooker, D.

      2004-04-01

      This presentation, which provides information about how hydrogen technology validation is used as a learning demonstration that feeds the research and development process, was given at a National Hydrogen Association meeting in April 2004.

    1. Contractor relationships and inter-organizational strategies in NASA's R and D acquisition process

      NASA Technical Reports Server (NTRS)

      Guiltinan, J.

      1976-01-01

      Interorganizational analysis of NASA's acquisition process for research and development systems is discussed. The importance of understanding the contractor environment, constraints, and motives in selecting an acquisition strategy is demonstrated. By articulating clear project goals, by utilizing information about the contractor and his needs at each stage in the acquisition process, and by thorough analysis of the inter-organizational relationship, improved selection of acquisition strategies and business practices is possible.

    2. Absence of Dbp2p Alters Both Nonsense-Mediated mRNA Decay and rRNA Processing

      PubMed Central

      Bond, Andrew T.; Mangus, David A.; He, Feng; Jacobson, Allan

      2001-01-01

      Dbp2p, a member of the large family of DEAD-box proteins and a yeast homolog of human p68, was shown to interact with Upf1p, an essential component of the nonsense-mediated mRNA decay pathway. Dbp2p:Upf1p interaction occurs within a large conserved region in the middle of Upf1p that is largely distinct from its Nmd2p and Sup35/45p interaction domains. Deletion of DBP2, or point mutations within its highly conserved DEAD-box motifs, increased the abundance of nonsense-containing transcripts, leading us to conclude that Dbp2p also functions in the nonsense-mediated mRNA decay pathway. Dbp2p, like Upf1p, acts before or at decapping, is predominantly cytoplasmic, and associates with polyribosomes. Interestingly, Dbp2p also plays an important role in rRNA processing. In dbp2Δ cells, polyribosome profiles are deficient in free 60S subunits and the mature 25S rRNA is greatly reduced. The ribosome biogenesis phenotype, but not the mRNA decay function, of dbp2Δ cells can be complemented by the human p68 gene. We propose a unifying model in which Dbp2p affects both nonsense-mediated mRNA decay and rRNA processing by altering rRNA structure, allowing specific processing events in one instance and facilitating dissociation of the translation termination complex in the other. PMID:11585918

    3. Separation and recovery process R&D to enhance automotive materials recycling

      SciTech Connect

      Daniels, E.J.

      1994-05-01

      Since 1976, the sales-weighted curb-weight of cars and light trucks sold in the United States has decreased by almost 800 pounds. Vehicle weight reduction has, of course, provided for a significant increase in US fleet fuel economy, from 17 to 27 miles per gallon. However, achievement of the weight reduction and concomitant increase in fuel economy was brought about, in part, by the substitution of lighter-weight materials, such as thinner-gauge coated sheet-steels replacing heavy-gauge noncoated sheet-steels and new aluminum alloys replacing steel as well as the increased use of plastics replacing metals. Each of these new materials has created the need for new technology for materials recycling. This paper highlights some of the R&D being conducted at Argonne National Laboratory to develop technology that will enhance and minimize the cost of automotive materials recycling.

    4. Comparative study of the bioconversion process using R-(+)- and S-(-)-limonene as substrates for Fusarium oxysporum 152B.

      PubMed

      Molina, Gustavo; Bution, Murillo L; Bicas, Juliano L; Dolder, Mary Anne Heidi; Pastore, Gláucia M

      2015-05-01

      This study compared the bioconversion process of S-(-)-limonene into limonene-1,2-diol with the already established biotransformation of R-(+)-limonene into α-terpineol using the same biocatalyst in both processes, Fusarium oxysporum 152B. The bioconversion of the S-(-)-isomer was tested on cell permeabilisation under anaerobic conditions and using a biphasic system. When submitted to permeabilisation trials, this biocatalyst has shown a relatively high resistance; still, no production of limonene-1,2-diol and a loss of activity of the biocatalyst were observed after intense cell treatment, indicating a complete loss of cell viability. Furthermore, the results showed that this process can be characterised as an aerobic system that was catalysed by limonene-1,2-epoxide hydrolase, had an intracellular nature and was cofactor-dependent because the final product was not detected by an anaerobic process. Finally, this is the first report to characterise the bioconversion of R-(+)- and S-(-)-limonene by cellular detoxification using ultra-structural analysis. PMID:25529726

    5. Chemistry of the Sagittarius dwarf galaxy: A top-light initial mass function, outflows, and the R-process

      SciTech Connect

      McWilliam, Andrew; Wallerstein, George; Mottini, Marta E-mail: walleg@u.washington.edu

      2013-12-01

      From chemical abundance analysis of stars in the Sagittarius dwarf spheroidal galaxy (Sgr), we conclude that the α-element deficiencies cannot be due to the Type Ia supernova (SN Ia) time-delay scenario of Tinsley. Instead, the evidence points to low [α/Fe] ratios resulting from an initial mass function (IMF) deficient in the highest mass stars. The critical evidence is the 0.4 dex deficiency of [O/Fe], [Mg/Fe], and other hydrostatic elements, contrasting with the normal trend of r-process [Eu/Fe] {sub r} with [Fe/H]. Supporting evidence comes from the hydrostatic element (O, Mg, Na, Al, Cu) [X/Fe] ratios, which are inconsistent with iron added to the Milky Way (MW) disk trends. Also, the ratio of hydrostatic to explosive (Si, Ca, Ti) element abundances suggests a relatively top-light IMF. Abundance similarities with the LMC, Fornax, and IC 1613 suggest that their α-element deficiencies also resulted from IMFs lacking the most massive SNe II. The top-light IMF, as well as the normal trend of r-process [Eu/Fe] {sub r} with [Fe/H] in Sgr, indicates that massive SNe II (≳30 M {sub ☉}) are not major sources of r-process elements. High [La/Y] ratios, consistent with leaky-box chemical evolution, are confirmed but ∼0.3 dex larger than theoretical asymptotic giant branch (AGB) predictions. This suggests that a substantial increase in the theoretical {sup 13}C pocket in low-mass AGB stars is required. Sgr has the lowest [Rb/Zr] ratios known, consistent with pollution by low-mass (≲2 M {sub ☉}) AGB stars near [Fe/H] = –0.6, likely resulting from leaky-box chemical evolution. The [Cu/O] trends in Sgr and the MW suggest that Cu yields increase with both metallicity and stellar mass, as expected from Cu production by the weak s-process in massive stars. Finally, we present an updated hyperfine splitting line list, an abundance analysis of Arcturus, and further develop our error analysis formalism.

    6. Chemistry of the Sagittarius Dwarf Galaxy: A Top-light Initial Mass Function, Outflows, and the R-process

      NASA Astrophysics Data System (ADS)

      McWilliam, Andrew; Wallerstein, George; Mottini, Marta

      2013-12-01

      From chemical abundance analysis of stars in the Sagittarius dwarf spheroidal galaxy (Sgr), we conclude that the α-element deficiencies cannot be due to the Type Ia supernova (SN Ia) time-delay scenario of Tinsley. Instead, the evidence points to low [α/Fe] ratios resulting from an initial mass function (IMF) deficient in the highest mass stars. The critical evidence is the 0.4 dex deficiency of [O/Fe], [Mg/Fe], and other hydrostatic elements, contrasting with the normal trend of r-process [Eu/Fe] r with [Fe/H]. Supporting evidence comes from the hydrostatic element (O, Mg, Na, Al, Cu) [X/Fe] ratios, which are inconsistent with iron added to the Milky Way (MW) disk trends. Also, the ratio of hydrostatic to explosive (Si, Ca, Ti) element abundances suggests a relatively top-light IMF. Abundance similarities with the LMC, Fornax, and IC 1613 suggest that their α-element deficiencies also resulted from IMFs lacking the most massive SNe II. The top-light IMF, as well as the normal trend of r-process [Eu/Fe] r with [Fe/H] in Sgr, indicates that massive SNe II (gsim30 M ⊙) are not major sources of r-process elements. High [La/Y] ratios, consistent with leaky-box chemical evolution, are confirmed but ~0.3 dex larger than theoretical asymptotic giant branch (AGB) predictions. This suggests that a substantial increase in the theoretical 13C pocket in low-mass AGB stars is required. Sgr has the lowest [Rb/Zr] ratios known, consistent with pollution by low-mass (lsim2 M ⊙) AGB stars near [Fe/H] = -0.6, likely resulting from leaky-box chemical evolution. The [Cu/O] trends in Sgr and the MW suggest that Cu yields increase with both metallicity and stellar mass, as expected from Cu production by the weak s-process in massive stars. Finally, we present an updated hyperfine splitting line list, an abundance analysis of Arcturus, and further develop our error analysis formalism.

    7. Seeking Comfort: Women Mental Health Process in I. R. Iran: A Grounded Theory Study

      PubMed Central

      Mohammadi, Farahnaz; Eftekhari, Monir Baradaran; Dejman, Masoumeh; Forouzan, Ameneh Setareh; Mirabzadeh, Arash

      2014-01-01

      Background: Psychosocial factor is considered as intermediate social determinant of health, because it has powerful effects on health especially in women. Hence deeper understanding of the mental-health process needed for its promotion. The aim of this study was to explore women's experience of the mental-health problem and related action-interactions activities to design the appropriate interventions. Methods: In-depth interviews with women 18-65 years were analyzed according to the grounded theory method. The selection of Participants was based on purposeful and theoretical sampling. Results: In this study, a substantive theory was generated; explaining how female with the mental-health problem handled their main concern, which was identified as their effort to achieve comfort (core variable). The other six categories are elements in this process. Daily stress as a trigger, satisfaction is the end point, marriage is the key point and action - interaction activities in this process are strengthening human essence, Developing life skills and help seeking. Conclusions: Better understanding the mental-health process might be useful to design the interventional program among women with mental-health problems. PMID:24627750

    8. Pennsylvania School Improvement Program. Selection Process. Analysis of R & D Outcomes.

      ERIC Educational Resources Information Center

      Trohoski, Carolyn

      The Pennsylvania School Improvement Program (PSIP) was created to assist local schools and school districts in the development of curriculum improvement strategies. The process involves the use of "linkers," curriculum specialists who work with teams from the local level to ascertain needs, then connect the local teams with the research and…

    9. Categories and Underlying Processes, or Representative Behavior Samples and S-R Analysis: Opposing Strategies.

      ERIC Educational Resources Information Center

      Staats, Arthur W.

      Psychological researchers should deal with the concrete stimulus-response principles of learning on which behavior is based, and study behaviors that are representative of real life behaviors. The present research strategy has come from two faulty ideas: first, a concern with underlying, inferred mental processes, rather than with actual tasks or…

    10. 24 CFR 235.1220 - Processing section 235(r) mortgages under the direct endorsement program.

      Code of Federal Regulations, 2011 CFR

      2011-04-01

      ... stated mortgage amount does not exceed the maximum dollar limitation under 24 CFR 235.1202(b)(1). (3... must meet for the direct endorsement program are contained in 24 CFR 203.5 and 203.255. Under those... processing. There are several provisions of 24 CFR 203.5 and 203.255 which do not apply to section...

    11. EVALUATION OF DIFFERENT SIGNAL PROCESSING OPTIONS IN UNILATERAL AND BILATERAL COCHLEAR FREEDOM IMPLANT RECIPIENTS USING R-SPACE™ BACKGROUND NOISE

      PubMed Central

      Brockmeyer, Alison M.; Potts, Lisa G.; Brockmeyer, Alison

      2013-01-01

      Background Difficulty understanding in background noise is a common complaint of cochlear implant (CI) recipients. Programming options are available to improve speech recognition in noise for CI users including Automatic Dynamic Range Optimization (ADRO), Autosensitivity Control (ASC), and BEAM. The processing option, however, which results in the best speech recognition in noise, is unknown. In addition, laboratory measures of these processing options often show greater degrees of improvement than reported by participants in everyday listening situations. To address this issue, Compton-Conley and colleagues developed a test system to replicate a restaurant environment. The R-SPACE™ consists of eight loudspeakers positioned in a 360 degree arc and utilizes a recording made at a restaurant of background noise. Purpose The present study measured speech recognition in the R-SPACE™ with four processing options: standard dual-port directional (STD), ADRO, ASC, and BEAM. Research Design A repeated measures, within-subject design was used to evaluate the four different processing options at two noise levels. Study Sample Twenty-seven unilateral and three bilateral adult Nucleus Freedom cochlear implant recipients. Intervention The participants’ everyday program (with no additional processing) was used as the STD program. ADRO, ASC, and BEAM were added individually to the STD program to create a total of four programs. Data Collection and Analysis Participants repeated HINT sentences presented at a 0 degree azimuth with R-SPACE™ restaurant noise at two noise levels, 60 and 70 dB SPL. The Reception Threshold for Sentences (RTS) was obtained for each processing condition and noise level. Results In 60 dB SPL noise, BEAM processing resulted in the best RTS, with a significant improvement over STD and ADRO processing. In 70 dB SPL noise, ASC and BEAM processing had significantly better mean RTSs compared to STD and ADRO processing. Comparison of noise levels showed that STD and BEAM processing resulted in significantly poorer RTSs in 70 dB SPL noise compared to the performance with these processing conditions in 60 dB SPL noise. Bilateral participants demonstrated a bilateral improvement compared to the better monaural condition for both noise levels and all processing conditions, except ASC in 60 dB SPL noise. Conclusions The results of this study suggest that the use of processing options that utilize noise reduction, like that available in ASC and BEAM, improve a CI recipient’s ability to understand speech in noise in listening situations similar to those experienced in the real-world. The choice of the best processing option is dependent on the noise level, with BEAM best at moderate noise levels and ASC best at loud noise levels for unilateral CI recipients. Therefore, multiple noise programs or a combination of processing options may be necessary to provide CI users with the best performance in a variety of listening situations. PMID:21463562

    12. Molecular diversity of eukaryotes in municipal wastewater treatment processes as revealed by 18S rRNA gene analysis.

      PubMed

      Matsunaga, Kengo; Kubota, Kengo; Harada, Hideki

      2014-01-01

      Eukaryotic communities involved in sewage treatment processes have been investigated by morphological identification, but have not yet been well-characterized using molecular approaches. In the present study, eukaryotic communities were characterized by constructing 18S rRNA gene clone libraries. The phylogenetic affiliations of a total of 843 clones were Alveolata, Fungi, Rhizaria, Euglenozoa, Stramenopiles, Amoebozoa, and Viridiplantae as protozoans and Rotifera, Gastrotricha, and Nematoda as metazoans. Sixty percent of the clones had <97% sequence identity to described eukaryotes, indicating the greater diversity of eukaryotes than previously recognized. A core OTU closely related to Epistylis chrysemydis was identified, and several OTUs were shared by 4-8 libraries. Members of the uncultured lineage LKM11 in Cryptomycota were predominant fungi in sewage treatment processes. This comparative study represents an initial step in furthering understanding of the diversity and role of eukaryotes in sewage treatment processes. PMID:25491751

    13. Molecular Diversity of Eukaryotes in Municipal Wastewater Treatment Processes as Revealed by 18S rRNA Gene Analysis

      PubMed Central

      Matsunaga, Kengo; Kubota, Kengo; Harada, Hideki

      2014-01-01

      Eukaryotic communities involved in sewage treatment processes have been investigated by morphological identification, but have not yet been well-characterized using molecular approaches. In the present study, eukaryotic communities were characterized by constructing 18S rRNA gene clone libraries. The phylogenetic affiliations of a total of 843 clones were Alveolata, Fungi, Rhizaria, Euglenozoa, Stramenopiles, Amoebozoa, and Viridiplantae as protozoans and Rotifera, Gastrotricha, and Nematoda as metazoans. Sixty percent of the clones had <97% sequence identity to described eukaryotes, indicating the greater diversity of eukaryotes than previously recognized. A core OTU closely related to Epistylis chrysemydis was identified, and several OTUs were shared by 4–8 libraries. Members of the uncultured lineage LKM11 in Cryptomycota were predominant fungi in sewage treatment processes. This comparative study represents an initial step in furthering understanding of the diversity and role of eukaryotes in sewage treatment processes. PMID:25491751

    14. FLEXIBLE APPLICATION OF THE JLAB PANSOPHY INFORMATION SYSTEM FOR PROJECT REPORTS, PROCESS MONITORING, AND R&D SAMPLE TRACKING

      SciTech Connect

      Valerie Bookwalter; Bonnie Madre; Charles Reece

      2008-02-12

      The use and features of the JLab SRF Institute IT system Pansophy1,2 continue to expand. In support of the cryomodule rework project for CEBAF a full set of web-based travelers has been implemented and an integrated set of live summary reports has been created. A graphical user interface within the reports enables navigation to either higher-level summaries or drill-down to the original source data. In addition to collection of episodic data, Pansophy is now used to capture, coordinate, and display continuously logged process parameter that relate to technical water systems and clean room environmental conditions. In a new expansion, Pansophy is being used to collect and track process and analytical data sets associated with SRF material samples that are part of the surface creation, processing, and characterization R&D program.

    15. Molecular diversity of eukaryotes in municipal wastewater treatment processes as revealed by 18S rRNA gene analysis.

      TOXLINE Toxicology Bibliographic Information

      Matsunaga K; Kubota K; Harada H

      2014-01-01

      Eukaryotic communities involved in sewage treatment processes have been investigated by morphological identification, but have not yet been well-characterized using molecular approaches. In the present study, eukaryotic communities were characterized by constructing 18S rRNA gene clone libraries. The phylogenetic affiliations of a total of 843 clones were Alveolata, Fungi, Rhizaria, Euglenozoa, Stramenopiles, Amoebozoa, and Viridiplantae as protozoans and Rotifera, Gastrotricha, and Nematoda as metazoans. Sixty percent of the clones had <97% sequence identity to described eukaryotes, indicating the greater diversity of eukaryotes than previously recognized. A core OTU closely related to Epistylis chrysemydis was identified, and several OTUs were shared by 4-8 libraries. Members of the uncultured lineage LKM11 in Cryptomycota were predominant fungi in sewage treatment processes. This comparative study represents an initial step in furthering understanding of the diversity and role of eukaryotes in sewage treatment processes.

    16. From Radtrack to eMWaste(r) G2 process-based integration

      SciTech Connect

      Bland, Jesse John

      2015-02-01

      This paper provides a process-based examination of the integration of two separate but related software applications into Sandia National Laboratories’ (SNL’s) Radioactive and Mixed Waste Management Facility’s (RMWMF) data management system. First, data collection will be upgraded through the use of a new web-based Waste Description and Disposal Request (WDDR), which SNL personnel whose work creates radioactive and hazardous waste (generators) will use to characterize dozens of specific attributes of each waste parcel. Second, a commercial software package for data storage and manipulation — eMWaste® G2 by Attention IT — will replace two existing software applications and will track all radioactive and mixed waste at Sandia. Integrating these applications into a web-based system will give the RMWMF increased system flexibility, reduced reliance on key personnel, and improved document control, traceability and efficiency. To meet these goals and ensure the applications are developed in an efficient, quality-oriented environment, it is critical to first conduct a thorough evaluation of the affected processes. This paper will analyze the processes supported by the new applications and the requirements for a successful integration. A comprehensive analysis of both project flow and data management requirements, illustrated through original flow diagrams and other charts, will provide support to the development team and programmers as they work to integrate the applications into the new system.

    17. β -decay half-lives of neutron-rich nuclei at A ~ 110 on r-process path

      NASA Astrophysics Data System (ADS)

      Nishizuka, Ippei; Sumikama, Toshiyuki; Browne, Frank; Bruce, Alison; Nishimura, Shunji; Doornenbal, Pieter; Lorusso, Giuseppe; Patel, Zena; Rice, Simon; Sinclair, Laura; Soderstom, Par-Ander; Watanabe, Hiroshi; Wu, Jin; Xu, Zhengyu; Yagi, Ayumi; Eurica Collaboration

      2014-09-01

      About half of the elements heavier than iron are thought to be produced by rapid-neutron capture process (r-process). The observed natural abundance in solar system was underestimated by a theoretical model at A ~ 110 , which uses β-decay half-lives. In the present study, we measured new β half-lives of neutron-rich nuclei on r-process path at RIBF in RIKEN. The nuclei of interest were produced by in-flight fission of uranium beam in beryllium target. The WAS3ABi detector which was 5 stacked double-sided silicon strip detectors (60 × 40 × 1 mm3), was used for the implantation of ions and the detection of both the implanted ions and the subsequently-emitted β rays. It is essential to make a position correlation between the mother nucleus and the β rays. In this talk, the analysis of the position correlation will be presented in detail. Preliminary results will be also shown.

    18. Evidence of Multiple r-Process Sites in the Early Galaxy: New Observations of CS 22892-052.

      PubMed

      Sneden; Cowan; Ivans; Fuller; Burles; Beers; Lawler

      2000-04-20

      First results are reported of a new abundance study of neutron-capture elements in the ultra-metal-poor (&sqbl0;Fe&solm0;H&sqbr0;=-3.1) halo field giant star CS 22892-052. Using new high-resolution, high signal-to-noise ratio spectra, abundances of more than 30 neutron-capture elements (Z>30) have been determined. Six elements in the 40/=56) stable neutron-capture elements in CS 22892-052 match well the scaled solar system r-process abundance distribution. From the observed Th abundance, an average age of approximately 16+/-4 Gyr is derived for CS 22892-052, consistent with the lower age limit of approximately 11 Gyr derived from the upper limit on the U abundance. The concordance of scaled solar r-process and CS 22892-052 abundances breaks down for the lighter neutron-capture elements, supporting previous suggestions that different r-process production sites are responsible for lighter and heavier neutron-capture elements. PMID:10770709

    19. Nuclear Structure and Astrophysics r-PROCESS with Covariant Density Functional Theory

      NASA Astrophysics Data System (ADS)

      Meng, J.; Long, W. H.; Niu, Z. M.; Sun, B.; Zhou, S. G.

      2010-09-01

      The density functional theory (DFT) with a minimal number of parameters allows a very successful phenomenological description of ground state properties of nuclei all over the periodic table. Recent progresses on the application of the covariant density functional theory as well as its extensions by the group in Beijing for a series of interests and hot topics in nuclear astrophysics and nuclear structure are reviewed, including the rapid neutron-capture process, Th/U chronometer, halo and giant halo in density dependent relativistic Hartree-Fock-Bogoliubov, and neutron halo in deformed nuclei.

    20. Shelf edge exchange processes-II SEEP2-06, R/V Endeavor cruise 186

      SciTech Connect

      Wilson, C.; Behrens, W.J.; Flagg, C.N.; Wallace, D.W.R.; Wilke, R.J.; Wyman, K.D.

      1989-12-01

      The Shelf Edge Exchange Processes (SEEP) program sponsored by the United States Department of Energy is a multi-institutional effort designed to investigate the flux of suspended material from the continental shelf to the waters of the upper slope, and then possibly into the slope sediments. Phase I of SEEP consisted of a series of nine cruises and a mooring array across the outer continental shelf of New England during 1983--1984. Phase II focused specifically on the shelf/slope frontal region of the mid-Atlantic bight off the Delmarva Peninsula. Hydrographic data were collected on eight of the six cruises.

    1. R&D processes for increasing density of cryogenic propellants at FSEC

      NASA Astrophysics Data System (ADS)

      Baik, Jong H.; T-Raissi, Ali

      2004-06-01

      At Florida Solar Energy Center (FSEC) of the University of Central Florida, we are probing processes for increasing density of cryogenic propellants for launch vehicle applications. Technologies that provide for the densification of cryogenic propellants, conditioning, transfer, storage and mass gauging are of prime interest to the spaceport of the future and space launch activities. Density increases of 8% for LH 2 and 10% for LO 2 have been shown to have the advantages of reduced gross lift-off weight of a launch vehicle by up to 20% or increased payload capability. In this paper, thermodynamic system analysis will be performed for various liquefaction, densification and recirculation systems. The objectives are to determine the optimum combination of system components including liquefier, cryocooler and heat exchangers for ground support system and launch vehicles. The base analysis results demonstrate various operation conditions and metrics to be used for optimization of densification processes that include higher efficiency, improved reliability and functionality with the state of the art technology.

    2. Shelf Edge Exchange Processes, II: SEEP2-08, R/V ENDEAVOR cruise 188

      SciTech Connect

      Wilson, C.; Behrens, W.J.; Flagg, C.N.; Wallace, D.W.R.; Wilke, R.J.; Wyman, K.D.

      1989-12-01

      The Shelf Edge Exchange Processes (SEEP) program sponsored by the United States Department of Energy is a multi-institutional effort designed to investigate the flux of suspended material from the continental shelf to the waters of the upper slope, and then possibly into the slope sediments. Phase I of SEEP consisted of a series of nine cruises and a mooring array across the outer continental shelf of New England during 1983--1984 (Behrens and Flagg, 1986). Phase II focused specifically on the shelf/slope frontal region of the mid-Atlantic bight off the Delmarva Peninsula. This project consisted of a series of ten cruises, a mooring array, and a series of over-flights by NASA aircraft. Hydrographic data were collected on eight of the cruises, six of which were primarily mooring deployment or recovery cruises. The cruises were consecutively designated SEEP2-01 to SEEP2-10. Two cruises (SEEP2-04 and SEEP2-07) were dedicated to investigating benthic processes and hydrographic data were not collected.

    3. Chloroplast RNA-Binding Protein RBD1 Promotes Chilling Tolerance through 23S rRNA Processing in Arabidopsis.

      PubMed

      Wang, Shuai; Bai, Ge; Wang, Shu; Yang, Leiyun; Yang, Fen; Wang, Yi; Zhu, Jian-Kang; Hua, Jian

      2016-05-01

      Plants have varying abilities to tolerate chilling (low but not freezing temperatures), and it is largely unknown how plants such as Arabidopsis thaliana achieve chilling tolerance. Here, we describe a genome-wide screen for genes important for chilling tolerance by their putative knockout mutants in Arabidopsis thaliana. Out of 11,000 T-DNA insertion mutant lines representing half of the genome, 54 lines associated with disruption of 49 genes had a drastic chilling sensitive phenotype. Sixteen of these genes encode proteins with chloroplast localization, suggesting a critical role of chloroplast function in chilling tolerance. Study of one of these proteins RBD1 with an RNA binding domain further reveals the importance of chloroplast translation in chilling tolerance. RBD1 is expressed in the green tissues and is localized in the chloroplast nucleoid. It binds directly to 23S rRNA and the binding is stronger under chilling than at normal growth temperatures. The rbd1 mutants are defective in generating mature 23S rRNAs and deficient in chloroplast protein synthesis especially under chilling conditions. Together, our study identifies RBD1 as a regulator of 23S rRNA processing and reveals the importance of chloroplast function especially protein translation in chilling tolerance. PMID:27138552

    4. Chloroplast RNA-Binding Protein RBD1 Promotes Chilling Tolerance through 23S rRNA Processing in Arabidopsis

      PubMed Central

      Yang, Leiyun; Yang, Fen; Wang, Yi; Zhu, Jian-Kang; Hua, Jian

      2016-01-01

      Plants have varying abilities to tolerate chilling (low but not freezing temperatures), and it is largely unknown how plants such as Arabidopsis thaliana achieve chilling tolerance. Here, we describe a genome-wide screen for genes important for chilling tolerance by their putative knockout mutants in Arabidopsis thaliana. Out of 11,000 T-DNA insertion mutant lines representing half of the genome, 54 lines associated with disruption of 49 genes had a drastic chilling sensitive phenotype. Sixteen of these genes encode proteins with chloroplast localization, suggesting a critical role of chloroplast function in chilling tolerance. Study of one of these proteins RBD1 with an RNA binding domain further reveals the importance of chloroplast translation in chilling tolerance. RBD1 is expressed in the green tissues and is localized in the chloroplast nucleoid. It binds directly to 23S rRNA and the binding is stronger under chilling than at normal growth temperatures. The rbd1 mutants are defective in generating mature 23S rRNAs and deficient in chloroplast protein synthesis especially under chilling conditions. Together, our study identifies RBD1 as a regulator of 23S rRNA processing and reveals the importance of chloroplast function especially protein translation in chilling tolerance. PMID:27138552

    5. Effects of simulated on-fire processing conditions on the microstructure and mechanical performance of Q345R steel

      NASA Astrophysics Data System (ADS)

      Peng, Yi-chao; Xu, Hao-hao; Zhang, Mai-cang

      2016-01-01

      A series of simulated on-fire processing experiments on Q345R steel plates was conducted, and the plates' Brinell hardness, tensile strength, and impact energy were tested. Microstructure morphologies were systematically analyzed using a scanning electron microscope with the aim of investigating the effect of the steel's microstructure on its performance. All examined performance parameters exhibited a substantial decrease in the cases of samples heat-treated at temperatures near 700°C. However, although the banded structure decreased with increasing treatment temperature and holding time, it had little effect on the performance decline in fact. Further analysis revealed that pearlite degeneration near 700°C, which was induced by the interaction of both subcritical annealing and conventional spherical annealing, was the primary reason for the degradation behavior. Consequently, some nonlinear mathematical models of different mechanical performances were established to facilitate processing adjustments.

    6. The crystal structure of Mtr4 reveals a novel arch domain required for rRNA processing

      SciTech Connect

      Jackson, R.N.; Robinson, H.; Klauer, A. A.; Hintze, B. J.; van Hoof, A.; Johnson, S. J.

      2010-07-01

      The essential RNA helicase, Mtr4, performs a critical role in RNA processing and degradation as an activator of the nuclear exosome. The molecular basis for this vital function is not understood and detailed analysis is significantly limited by the lack of structural data. In this study, we present the crystal structure of Mtr4. The structure reveals a new arch-like domain that is specific to Mtr4 and Ski2 (the cytosolic homologue of Mtr4). In vivo and in vitro analyses demonstrate that the Mtr4 arch domain is required for proper 5.8S rRNA processing, and suggest that the arch functions independently of canonical helicase activity. In addition, extensive conservation along the face of the putative RNA exit site highlights a potential interface with the exosome. These studies provide a molecular framework for understanding fundamental aspects of helicase function in exosome activation, and more broadly define the molecular architecture of Ski2-like helicases.

    7. Disruption of ribosome assembly in yeast blocks cotranscriptional pre-rRNA processing and affects the global hierarchy of ribosome biogenesis.

      PubMed

      Talkish, Jason; Biedka, Stephanie; Jakovljevic, Jelena; Zhang, Jingyu; Tang, Lan; Strahler, John R; Andrews, Philip C; Maddock, Janine R; Woolford, John L

      2016-06-01

      In higher eukaryotes, pre-rRNA processing occurs almost exclusively post-transcriptionally. This is not the case in rapidly dividing yeast, as the majority of nascent pre-rRNAs are processed cotranscriptionally, with cleavage at the A2 site first releasing a pre-40S ribosomal subunit followed by release of a pre-60S ribosomal subunit upon transcription termination. Ribosome assembly is driven in part by hierarchical association of assembly factors and r-proteins. Groups of proteins are thought to associate with pre-ribosomes cotranscriptionally during early assembly steps, whereas others associate later, after transcription is completed. Here we describe a previously uncharacterized phenotype observed upon disruption of ribosome assembly, in which normally late-binding proteins associate earlier, with pre-ribosomes containing 35S pre-rRNA. As previously observed by many other groups, we show that disruption of 60S subunit biogenesis results in increased amounts of 35S pre-rRNA, suggesting that a greater fraction of pre-rRNAs are processed post-transcriptionally. Surprisingly, we found that early pre-ribosomes containing 35S pre-rRNA also contain proteins previously thought to only associate with pre-ribosomes after early pre-rRNA processing steps have separated maturation of the two subunits. We believe the shift to post-transcriptional processing is ultimately due to decreased cellular division upon disruption of ribosome assembly. When cells are grown under stress or to high density, a greater fraction of pre-rRNAs are processed post-transcriptionally and follow an alternative processing pathway. Together, these results affirm the principle that ribosome assembly occurs through different, parallel assembly pathways and suggest that there is a kinetic foot-race between the formation of protein binding sites and pre-rRNA processing events. PMID:27036125

    8. Unit operations used to treat process and/or waste streams at nuclear power plants. [R

      SciTech Connect

      Godbee, H.W.; Kibbey, A.H.

      1980-01-01

      Estimates are given of the annual amounts of each generic type of LLW (i.e., Government and commerical (fuel cycle and non-fuel cycle)) that is generated at LWR plants. Many different chemical engineering unit operations used to treat process and/or waste streams at LWR plants include adsorption, evaporation, calcination, centrifugation, compaction, crystallization, drying, filtration, incineration, reverse osmosis, and solidification of waste residues. The treatment of these various streams and the secondary wet solid wastes thus generated is described. The various treatment options for concentrates or solid wet wastes, and for dry wastes are discussed. Among the dry waste treatment methods are compaction, baling, and incineration, as well as chopping, cutting and shredding. Organic materials (liquids (e.g., oils or solvents) and/or solids), could be incinerated in most cases. The filter sludges, spent resins, and concentrated liquids (e.g., evaporator concentrates) are usually solidified in cement, or urea-formaldehyde or unsaturated polyester resins prior to burial. Incinerator ashes can also be incorporated in these binding agents. Asphalt has not yet been used. This paper presents a brief survey of operational experience at LWRs with various unit operations, including a short discussion of problems and some observations on recent trends.

    9. Apollo(R) Thin Film Process Development: Final Technical Report, April 1998 - April 2002

      SciTech Connect

      Cunningham, D.W.

      2002-10-01

      BP Solar first started investigative work on CdTe photovoltaics in 1986. The module product name chosen for the CdTe devices is Apollo. The deposition method chosen was electrochemical deposition due to its simplicity and good control of stoichiometric composition. The window layer used is CdS, produced from a chemical-bath deposition. Initial work focused on increasing photovoltaic cell size from a few mm2 to 900 cm2. At BP Solar's Fairfield plant, work is focused on increasing semiconductor deposition to 1 m2. The primary objective of this subcontract is to establish the conditions required for the efficient plating of CdS/CdTe on large-area, transparent conducting tin-oxide-coated glass superstrate. The initial phase concentrates on superstrate sizes up to 0.55 m2. Later phases will include work on 0.94 m2 superstrates. The tasks in this subcontract have been split into four main categories: (1) CdS and CdTe film studies; (2) Enhanced laser processing; (3) Outdoor testing program for the Apollo module; and (4) Production waste abatement and closed loop study.

    10. A divergent Pumilio repeat protein family for pre-rRNA processing and mRNA localization

      PubMed Central

      Qiu, Chen; McCann, Kathleen L.; Wine, Robert N.; Baserga, Susan J.; Hall, Traci M. Tanaka

      2014-01-01

      Pumilio/feminization of XX and XO animals (fem)-3 mRNA-binding factor (PUF) proteins bind sequence specifically to mRNA targets using a single-stranded RNA-binding domain comprising eight Pumilio (PUM) repeats. PUM repeats have now been identified in proteins that function in pre-rRNA processing, including human Puf-A and yeast Puf6. This is a role not previously ascribed to PUF proteins. Here we present crystal structures of human Puf-A that reveal a class of nucleic acid-binding proteins with 11 PUM repeats arranged in an “L”-like shape. In contrast to classical PUF proteins, Puf-A forms sequence-independent interactions with DNA or RNA, mediated by conserved basic residues. We demonstrate that equivalent basic residues in yeast Puf6 are important for RNA binding, pre-rRNA processing, and mRNA localization. Thus, PUM repeats can be assembled into alternative folds that bind to structured nucleic acids in addition to forming canonical eight-repeat crescent-shaped RNA-binding domains found in classical PUF proteins. PMID:25512524

    11. A divergent Pumilio repeat protein family for pre-rRNA processing and mRNA localization.

      PubMed

      Qiu, Chen; McCann, Kathleen L; Wine, Robert N; Baserga, Susan J; Hall, Traci M Tanaka

      2014-12-30

      Pumilio/feminization of XX and XO animals (fem)-3 mRNA-binding factor (PUF) proteins bind sequence specifically to mRNA targets using a single-stranded RNA-binding domain comprising eight Pumilio (PUM) repeats. PUM repeats have now been identified in proteins that function in pre-rRNA processing, including human Puf-A and yeast Puf6. This is a role not previously ascribed to PUF proteins. Here we present crystal structures of human Puf-A that reveal a class of nucleic acid-binding proteins with 11 PUM repeats arranged in an "L"-like shape. In contrast to classical PUF proteins, Puf-A forms sequence-independent interactions with DNA or RNA, mediated by conserved basic residues. We demonstrate that equivalent basic residues in yeast Puf6 are important for RNA binding, pre-rRNA processing, and mRNA localization. Thus, PUM repeats can be assembled into alternative folds that bind to structured nucleic acids in addition to forming canonical eight-repeat crescent-shaped RNA-binding domains found in classical PUF proteins. PMID:25512524

    12. VizieR Online Data Catalog: Deuteration in massive star formation process (Fontani+, 2015)

      NASA Astrophysics Data System (ADS)

      Fontani, F.; Busquet, G.; Palau, A.; Caselli, P. Sanchez-Monge A.; Tan, J. C.; Audard, M.

      2014-11-01

      An ever growing number of observational and theoretical evidence suggests that the deuterated fraction (column density ratio between a species containing D and its hydrogenated counterpart, Dfrac) is an evolutionary indicator both in the low- and the high-mass star formation process. However, the role of surface chemistry in these studies has not been quantified from an observational point of view. In order to compare how the deuterated fractions of species formed only in the gas and partially or uniquely on grain surfaces evolve with time, we observed rotational transitions of CH3OH, 13CH3OH, CH2DOH, CH3OD at 3 and 1.3mm, and of NH2D at 3mm with the IRAM-30m telescope, and the inversion transitions (1,1) and (2,2) of NH3 with the GBT, towards most of the cores already observed by Fontani et al. (2011A&A...529L...7F, 2014MNRAS.440..448F) in N2H+, N2D+, HNC, DNC. NH2D is detected in all but two cores, regardless of the evolutionary stage. Dfrac(NH3) is on average above 0.1, and does not change significantly from the earliest to the most evolved phases, although the highest average value is found in the protostellar phase (~0.3). Few lines of CH2DOH and CH3OD are clearly detected, and only towards protostellar cores or externally heated starless cores. This work clearly confirms an expected different evolutionary trend of the species formed exclusively in the gas (N2D+ and N2H+) and those formed partially (NH2D and NH3) or totally (CH2DOH and CH3OH) on grain mantles. The study also reinforces the idea that Dfrac(N2H+) is the best tracer of massive starless cores, while high values of Dfrac(CH3OH) seem rather good tracers of the early protostellar phases, at which the evaporation/sputtering of the grain mantles is most efficient. (6 data files).

    13. R and D investment strategies for condition-based maintenance: An economic model to assist process, plant, and management in the decision making process

      SciTech Connect

      Allgood, G.O.

      1998-04-01

      In today`s manufacturing environment, systems and equipment are being asked to perform at levels not thought possible a decade ago. The intent is to push process operations, product quality, and equipment reliability, availability, and maintainability to unprecedented levels while maintaining budgetary structures consistent with cost reduction initiatives. In light of this, there is a demand to reduce operational and support costs and eliminate or minimize any new capital investments in plant equipment while increasing process efficiency and revenues. In short, manufacturers are trying to invoke new measures to ensure plant performance while minimizing costs and extending operational life of new and/or aging equipment. The only way this can be accomplished is by developing new and innovating approaches in condition-based maintenance. To achieve this while adhering to strict economic constraints requires the development of new sensors, systems, and methods for interrogating, diagnosing, and controlling systems. The old adage, business as usual, will not suffice in this new way of thinking. What will be required is an investment strategy that mitigates R and D risks by developing economic indicators (operational and costs) that qualify the ability of a proposed technology to meet the functional and operational needs of a process. The strategy must, therefore, internalize a methodology and approach that provides control points in the development and implementation cycle. An integral part of this is an economic model that provides a break-even analysis and sensor and system performance assessment based on the concentration of losses and the ability of a proposed sensor to meet systematic needs. This model then becomes a tool for strategizing continued research and development (R and D) for any proposed technology.

    14. MOLYBDENUM, RUTHENIUM, AND THE HEAVY r-PROCESS ELEMENTS IN MODERATELY METAL-POOR MAIN-SEQUENCE TURNOFF STARS

      SciTech Connect

      Peterson, Ruth C.

      2013-05-01

      The ratios of elemental abundances observed in metal-poor stars of the Galactic halo provide a unique present-day record of the nucleosynthesis products of its earliest stars. While the heaviest elements were synthesized by the r- and s-processes, dominant production mechanisms of light trans-ironic elements were obscure until recently. This work investigates further our 2011 conclusion that the low-entropy regime of a high-entropy wind (HEW) produced molybdenum and ruthenium in two moderately metal-poor turnoff stars that showed extreme overabundances of those elements with respect to iron. Only a few, rare nucleosynthesis events may have been involved. Here we determine abundances for Mo, Ru, and other trans-Fe elements for 28 similar stars by matching spectral calculations to well-exposed near-UV Keck HIRES spectra obtained for beryllium abundances. In each of the 26 turnoff stars with Mo or Ru line detections and no evidence for s-process production (therefore old), we find Mo and Ru to be three to six times overabundant. In contrast, the maximum overabundance is reduced to factors of three and two for the neighboring elements zirconium and palladium. Since the overproduction peaks sharply at Mo and Ru, a low-entropy HEW is confirmed as its origin. The overabundance level of the heavy r-process elements varies significantly, from none to a factor of four, but is uncorrelated with Mo and Ru overabundances. Despite their moderate metallicity, stars in this group trace the products of different nucleosynthetic events: possibly very few events, possibly events whose output depended on environment, metallicity, or time.

    15. The origin and evolution of r- and s-process elements in the Milky Way stellar disk

      NASA Astrophysics Data System (ADS)

      Battistini, Chiara; Bensby, Thomas

      2016-02-01

      Context. Elements heavier than iron are produced through neutron-capture processes in the different phases of stellar evolution. Asymptotic giant branch (AGB) stars are believed to be mainly responsible for elements that form through the slow neutron-capture process, while the elements created in the rapid neutron-capture process have production sites that are less understood. Knowledge of abundance ratios as functions of metallicity can lead to insight into the origin and evolution of our Galaxy and its stellar populations. Aims: We aim to trace the chemical evolution of the neutron-capture elements Sr, Zr, La, Ce, Nd, Sm, and Eu in the Milky Way stellar disk. This will allow us to constrain the formation sites of these elements, as well as to probe the evolution of the Galactic thin and thick disks. Methods: Using spectra of high resolution (42 000 ≲ R ≲ 65 000) and high signal-to-noise (S/N ≳ 200) obtained with the MIKE and the FEROS spectrographs, we determine Sr, Zr, La, Ce, Nd, Sm, and Eu abundances for a sample of 593 F and G dwarf stars in the solar neighborhood. The abundance analysis is based on spectral synthesis using one-dimensional, plane-parallel, local thermodynamic equilibrium (LTE) model stellar atmospheres calculated with the MARCS 2012 code. Results: We present abundance results for Sr (156 stars), Zr (311 stars), La (242 stars), Ce (365 stars), Nd (395 stars), Sm (280 stars), and Eu (378 stars). We find that Nd, Sm, and Eu show trends similar to what is observed for the α elements in the [X/Fe]-[Fe/H] abundance plane. For [Sr/Fe] and [Zr/Fe], we find decreasing abundance ratios for increasing metallicity, reaching sub-solar values at super-solar metallicities. [La/Fe] and [Ce/Fe] do not show any clear trend with metallicity, and they are close to solar values at all [Fe/H]. The trends of abundance ratios [X/Fe] as a function of stellar ages present different slopes before and after 8 Gyr. Conclusions: The rapid neutron-capture process is active early in the Galaxy, mainly in type-II supernovae from stars in the mass range 8-10 M⊙. Europium is almost completely produced by the r-process, but Nd and Sm show similar trends to Eu even if their s-process component is higher. Strontium and Zr are thought to be mainly produced by the s-process, but show significant enrichment at low metallicity that requires extra r-process production, which probably is different from the classical r-process. Finally, La and Ce are mainly produced via s-process from AGB stars in the mass range 2-4 M⊙, which can be seen by the decrease in [La/Eu] and [Ce/Eu] at [Fe/H] ≈ -0.5. The trend of [X/Fe] with age could be explained by considering that the decrease in [X/Fe] for the thick disk stars can be due to the decrease in type-II supernovae with time, meaning a reduced enrichment of r-process elements in the interstellar medium. In the thin disk, the trends are flatter, which is probably due to the main production from the s-process being balanced by Fe production from type-Ia supernovae. This paper includes data gathered with the 6.5 m Magellan Telescopes at the Las Campanas Observatory, Chile and the ESO 1.5-m, 2.2-m. and 3.6-m telescopes on La Silla, Chile (ESO Proposal ID 65.L-0019, 67.B-0108, 76.B-0416, 82.B-0610); and data from UVES Paranal Observatory Project (ESO DDT Program ID 266.D-5655).Full Tables 3 and 4 are only available at the CDS via anonymous ftp to http://cdsarc.u-strasbg.fr (ftp://130.79.128.5) or via http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/586/A49

    16. Short-lived 244Pu points to compact binary mergers as sites for heavy r-process nucleosynthesis

      NASA Astrophysics Data System (ADS)

      Hotokezaka, Kenta; Piran, Tsvi; Paul, Michael

      2015-12-01

      The origin of heavy elements produced through rapid neutron capture (`r-process’) by seed nuclei is one of the current nucleosynthesis mysteries. Core collapse supernovae (cc-SNe; ref. ) and compact binary mergers are considered as possible sites. The first produces small amounts of material at a high event rate whereas the latter produces large amounts in rare events. Radioactive elements with the right lifetime can break the degeneracy between high-rate/low-yield and low-rate/high-yield scenarios. Among radioactive elements, most interesting is 244Pu (half-life of 81 million years), for which both the current accumulation of live 244Pu particles accreted via interstellar particles in the Earth’s deep-sea floor and the Early Solar System (ESS) abundances have been measured. Interestingly, the estimated 244Pu abundance in the current interstellar medium inferred from deep-sea measurements is significantly lower than that corresponding to the ESS measurements. Here we show that both the current and ESS abundances of 244Pu are naturally explained within the low-rate/high-yield scenario. The inferred event rate remarkably agrees with compact binary merger rates estimated from Galactic neutron star binaries and from short gamma-ray bursts. Furthermore, the ejected mass of r-process elements per event agrees with both theoretical and observational macronova/kilonova estimates.

    17. The Fuel Processing Research Facility - A Platform for the Conduct of Synthesis Gas Technology R&D

      SciTech Connect

      Monahan, Michael J.; Berry, David A.; Gardner, Todd H.; Lyons, K. David

      2001-11-06

      Vision 21 is the U. S. Department of Energy's initiative to deploy high efficiency, ultraclean co-production coal conversion power plants in the twenty-first century. These plants will consist of power and co-production modules, which are integrated to meet specific power and chemical markets. A variety of fuel gas processing technology issues involving gas separations, cleanup, gas-to-liquid fuels production and chemical synthesis, to mention a few, will be addressed by the program. The overall goal is to effectively eliminate, at competitive costs, environmental concerns associated with the use of fossil fuels for producing electricity and transportation fuels. The Fuel Processing Research Facility (FPRF) was developed as a fuel-flexible platform to address many of these technology needs. The facility utilizes a simplified syngas generator that is capable of producing 2,000 standard cubic feet per hour of 900 degree Celsius and 30 atmosphere synthesis gas that can be tailored to the gas composition of interest. It was built on a ''mid-scale'' level in an attempt to successfully branch the traditionally difficult scale-up from laboratory to pilot scale. When completed, the facility will provide a multi-faceted R&D area for the testing of fuel cells, gas separation technologies, and other gas processing unit operations.

    18. Shelf Edge Exchange Processes: 2, SEEP2-09, R/V ENDEAVOR cruise 193: Hydrographic data report

      SciTech Connect

      Behrens, W.J.; Wilson, C.; Flagg, C.N.; Wallace, D.W.R.; Wilke, R.J.; Wyman, K.D.

      1990-01-01

      The R/V ENDEAVOR cruise 193, SEEP2-09, took place from 17--23 March 1989 and focused primarily on biological processes in the SEEP2 area. Mooring 1 was recovered and re-deployed and a replacement for mooring 4 was deployed. A 24 hour time series was conducted at mooring 1 to study primary and secondary production. The time series involved sampling nutrients, dissolved oxygen, chlorophyll {und a}, zooplankton abundance and distribution and fecal pellet production. Experiments to estimate grazing rates the fecal pellet production of the dominant copepods were also done. MOCNESS tows and box core samples were also taken during the cruise. Sediment and zooplankton data are not reported here. During this cruise 46 CTD casts were made measuring pressure, temperature, conductivity, dissolved oxygen, fluorescence and light transmission. Discrete samples were taken in rosette-mounted Niskin bottles and analyzed for concentration of nutrients, chlorophyll {und a}, dissolved oxygen, and particulate organic carbon and nitrogen.

    19. ?-decay rates of r-process waiting-point nuclei in the extended quasiparticle random-phase approximation

      NASA Astrophysics Data System (ADS)

      Ni, Dongdong; Ren, Zhongzhou

      2014-02-01

      The ?- decays of the r-process waiting-point nuclei at the neutron magic numbers N = 50 and N = 82 are investigated within the extended quasiparticle random-phase approximation (QRPA), where neutron-neutron, proton-proton and neutron-proton (np) pairing correlations are considered in the specialized Hartree-Fock-Bogoliubov (HFB) calculation. The Brckner G-matrix obtained with the charge-dependent Bonn nucleon-nucleon force is used for the residual particle-particle and particle-hole interaction in addition to the pairing interaction. It is found that the np pairing interaction plays an important role in reducing the calculated ?--decay half-lives. The calculations with np pairing show good agreement with the available experimental data including the decay half-lives of Ni isotopes, which are usually overestimated in the self-consistent proton-neutron QRPA calculations.

    20. Transcript-based Cloning of RRP46, a Regulator of rRNA Processing and R-Gene-Independent Cell Death in Barley–Powdery Mildew Interactions

      Technology Transfer Automated Retrieval System (TEKTRAN)

      Programmed cell death (PCD) plays a pivotal role in plant development and defense. To investigate the degree of interaction between PCD and R-gene mediated defense, we used the 22K Barley1 GeneChip to compare and contrast time-course expression profiles of Blumeria graminis f. sp. hordei (Bgh) chal...

    1. The long-term evolution of neutron star merger remnants - I. The impact of r-process nucleosynthesis

      NASA Astrophysics Data System (ADS)

      Rosswog, S.; Korobkin, O.; Arcones, A.; Thielemann, F.-K.; Piran, T.

      2014-03-01

      We follow the long-term evolution of the dynamic ejecta of neutron star mergers for up to 100 years and over a density range of roughly 40 orders of magnitude. We include the nuclear energy input from the freshly synthesized, radioactively decaying nuclei in our simulations and study its effects on the remnant dynamics. Although the nuclear heating substantially alters the long-term evolution, we find that running nuclear networks over purely hydrodynamic simulations (i.e. without heating) yields actually acceptable nucleosynthesis results. The main dynamic effect of the radioactive heating is to quickly smooth out inhomogeneities in the initial mass distribution, subsequently the evolution proceeds self-similarly and after 100 years the remnant still carries the memory of the initial binary mass ratio. We also explore the nucleosynthetic yields for two mass ejection channels. The dynamic ejecta very robustly produce `strong' r-process elements with A > 130 with a pattern that is essentially independent of the details of the merging system. From a simple model we find that neutrino-driven winds yield `weak' r-process contributions with 50 < A < 130 whose abundance patterns vary substantially between different merger cases. This is because their electron fraction, set by the ratio of neutrino luminosities, varies considerably from case to case. Such winds do not produce any 56Ni, but a range of radioactive isotopes that are long-lived enough to produce a second, radioactively powered electromagnetic transient in addition to the `macronova' from the dynamic ejecta. While our wind model is very simple, it nevertheless demonstrates the potential of such neutrino-driven winds for electromagnetic transients and it motivates further, more detailed neutrino-hydrodynamic studies. The properties of the mentioned transients are discussed in more detail in a companion paper.

    2. Large-scale B-spline R-matrix calculations of electron impact excitation and ionization processes in complex atoms

      NASA Astrophysics Data System (ADS)

      Zatsarinny, Oleg

      2013-09-01

      In recent years, the B-spline R-matrix (BSR) method has been applied to the treatment of a large number of atomic structure and electron-atom collision problems. Characteristic features of the BSR approach include the use of B-splines as a universal basis to describe the projectile electron inside the R-matrix box and the employment of term-dependent, and hence non-orthogonal, orbitals to construct the target states. The latter flexibility has proven to be of crucial importance for complex targets with several partially filled subshells. The published computer code has since been updated and extended to allow for a fully relativistic description at the level of the Dirac-Coulomb hamiltonian. Also, the systematic inclusion of a large number of pseudo-states in the close-coupling expansion has made it possible to extend the range of applicability from elastic and inelastic low-energy near-threshold phenomena to intermediate energies (up to several times the ionization threshold) and, in particular, to describe ionization processes as well. The basic ideas of the BSR approach will be reviewed, and its application will be illustrated for a variety of targets. Particular emphasis will be placed on systems of relevance for applications in gaseous electronics, such as the generation of complete datasets for electron collisions with the heavy noble gases Ne-Xe. Many of our data, which are needed for the description of transport processes in plasmas, are available through the LXCat database. This work was performed in collaboration with Klaus Bartschat. It is supported by the National Science Foundation under Grant No. PHY-1212450 and the XSEDE Allocation PHY-090031.

    3. The Binary Frequency of r-Process-element-enhanced Metal-poor Stars and Its Implications: Chemical Tagging in the Primitive Halo of the Milky Way

      NASA Astrophysics Data System (ADS)

      Hansen, Terese; Andersen, Johannes; Nordstrm, Birgitta; Buchhave, Lars A.; Beers, Timothy C.

      2011-12-01

      A few rare halo giants in the range [Fe/H] ~= -2.9 0.3 exhibit r-process element abundances that vary as a group by factors up to [r/Fe] ~80, relative to those of the iron peak and below. Yet, the astrophysical production site of these r-process elements remains unclear. We report initial results from four years of monitoring the radial velocities of 17 r-process-enhanced metal-poor giants to detect and characterize binaries in this sample. We find three (possibly four) spectroscopic binaries with orbital periods and eccentricities that are indistinguishable from those of Population I binaries with giant primaries, and which exhibit no signs that the secondary components have passed through the asymptotic giant branch stage of evolution or exploded as supernovae. The other 14 stars in our sample appear to be singleincluding the prototypical r-process-element-enhanced star CS 22892-052, which is also enhanced in carbon, but not in s-process elements. We conclude that the r-process (and potentially carbon) enhancement of these stars was not a local event due to mass transfer or winds from a binary companion, but was imprinted on the natal molecular clouds of these (single and binary) stars by an external source. These stars are thus spectacular chemical tracers of the inhomogeneous nature of the early Galactic halo system.

    4. The loop structure and the RNA helicase p72/DDX17 influence the processing efficiency of the mice miR-132.

      PubMed

      Remenyi, Judit; Bajan, Sarah; Fuller-Pace, Frances V; Arthur, J Simon C; Hutvagner, Gyorgy

      2016-01-01

      miRNAs are small RNAs that are key regulators of gene expression in eukaryotic organisms. The processing of miRNAs is regulated by structural characteristics of the RNA and is also tightly controlled by auxiliary protein factors. Among them, RNA binding proteins play crucial roles to facilitate or inhibit miRNA maturation and can be controlled in a cell, tissue and species-specific manners or in response to environmental stimuli. In this study we dissect the molecular mechanism that promotes the overexpression of miR-132 in mice over its related, co-transcribed and co-regulated miRNA, miR-212. We have shown that the loop structure of miR-132 is a key determinant for its efficient processing in cells. We have also identified a range of RNA binding proteins that recognize the loop of miR-132 and influence both miR-132 and miR-212 processing. The DEAD box helicase p72/DDX17 was identified as a factor that facilitates the specific processing of miR-132. PMID:26947125

    5. The loop structure and the RNA helicase p72/DDX17 influence the processing efficiency of the mice miR-132

      PubMed Central

      Remenyi, Judit; Bajan, Sarah; Fuller-Pace, Frances V.; Arthur, J. Simon C.; Hutvagner, Gyorgy

      2016-01-01

      miRNAs are small RNAs that are key regulators of gene expression in eukaryotic organisms. The processing of miRNAs is regulated by structural characteristics of the RNA and is also tightly controlled by auxiliary protein factors. Among them, RNA binding proteins play crucial roles to facilitate or inhibit miRNA maturation and can be controlled in a cell, tissue and species-specific manners or in response to environmental stimuli. In this study we dissect the molecular mechanism that promotes the overexpression of miR-132 in mice over its related, co-transcribed and co-regulated miRNA, miR-212. We have shown that the loop structure of miR-132 is a key determinant for its efficient processing in cells. We have also identified a range of RNA binding proteins that recognize the loop of miR-132 and influence both miR-132 and miR-212 processing. The DEAD box helicase p72/DDX17 was identified as a factor that facilitates the specific processing of miR-132. PMID:26947125

    6. Elevated p53 promotes the processing of miR-18a to decrease estrogen receptor-α in female hepatocellular carcinoma.

      PubMed

      Li, Chiao-Ling; Yeh, Kun-Huei; Liu, Wan-Hsin; Chen, Chi-Ling; Chen, Ding-Shinn; Chen, Pei-Jer; Yeh, Shiou-Hwei

      2015-02-15

      The estrogen pathway has long been implicated as a tumor protector in female hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC). Our previous study identified that estrogen receptor alpha (ERα) protein is downregulated in 60% of female HCC cases, via a miR-18a elevation mediated suppression of ERα translation. This study aims to delineate the mechanism underlying the upregulation of miR-18a in female HCC. The analysis of 77 female HCC specimens revealed that miR-18a levels were associated with pre-miR-18a rather than pri-miR-18a levels, suggesting an enhanced processing of pri- to pre-miR-18a. Among a panel of factors involved in microRNA processing, p53 was identified as a novel regulator for miR-18a maturation process. Knockdown of p53 by si-RNA decreased the level of miR-18a, whereas overexpression of either wild-type or mutant p53 increased its level. The association between the elevation of miR-18a and the accumulation of p53, mainly caused by somatic mutations, was confirmed in the clinical specimens of HBV-related female HCC. By analyzing the association with clinicopathological features, activation of this p53/miR-18a pathway mainly occurs in younger or noncirrhosis female HCC patients and associated with a trend of worse overall survival. Therefore, this study demonstrated a novel function of elevated/mutant p53 in regulating the amount of ERα protein through its promoting the biogenesis of miR-18a, which could lead to decrease the tumor-protective function of the estrogen pathway in female hepatocarcinogenesis. PMID:24975878

    7. Surface processes in microgravity for landing and sampling site selection of asteroid missions-Suggestions for MarcoPolo-R

      NASA Astrophysics Data System (ADS)

      Kereszturi, Akos

      2014-10-01

      Surface properties of small asteroids are reviewed in this work focusing on microgravity related processes in order to give constrains for targeting sample acquisition by next missions, especially for MarcoPolo-R proposed by ESA. Based on our current knowledge and the planned capabilities of this mission, good chance exists to get answers for the following basic questions. Formation method of nanophase iron and amorphous ingredients in the regolith could be determined, surface particle size and regolith density estimation would also be gained, and with extrapolation to the rest of the surface, knowledge on transport processes, ages and results of cratering under special gravity-strength regime will be improved. Searching for fresh material on asteroid surface in general requires sophisticated effort, as small craters often do not produce much ejecta in microgravity, but the bright annuli around them could be the result of local surface disturbance, while slopes often exhibit fresh material. To identify these locations high albedo, bluer colour and occasionally the depth of 1 μm absorption band could be useful as they often change parallel to each other. To identify the best area for sample acquisition addresses a strategic question: while smooth terrains with easy navigation and sample acquisition provide strongly weathered fine grains; steeper terrains give access to less weathered, material more representative for the whole asteroid, but navigation and mechanical sampling rise difficulties there.

    8. The new model of chemical evolution of r-process elements based on the hierarchical galaxy formation. I. Ba and Eu

      SciTech Connect

      Komiya, Yutaka; Suda, Takuma; Yamada, Shimako; Fujimoto, Masayuki Y.

      2014-03-10

      We investigate the chemical enrichment of r-process elements in the early evolutionary stages of the Milky Way halo within the framework of hierarchical galaxy formation using a semi-analytic merger tree. In this paper, we focus on heavy r-process elements, Ba and Eu, of extremely metal-poor (EMP) stars and give constraints on their astronomical sites. Our models take into account changes of the surface abundances of EMP stars by the accretion of interstellar medium (ISM). We also consider metal-enrichment of intergalactic medium by galactic winds and the resultant pre-enrichment of proto-galaxies. The trend and scatter of the observed r-process abundances are well reproduced by our hierarchical model with ∼10% of core-collapse supernovae in low-mass end (∼10 M {sub ☉}) as a dominant r-process source and the star formation efficiency of ∼10{sup –10} yr{sup –1}. For neutron star mergers as an r-process source, their coalescence timescale has to be ∼10{sup 7} yr, and the event rates ∼100 times larger than currently observed in the Galaxy. We find that the accretion of ISM is a dominant source of r-process elements for stars with [Ba/H] < –3.5. In this model, a majority of stars at [Fe/H] < –3 are formed without r-process elements, but their surfaces are polluted by the ISM accretion. The pre-enrichment affects ∼4% of proto-galaxies, and yet, is surpassed by the ISM accretion in the surface of EMP stars.

    9. A high-entropy-wind r-process study based on nuclear-structure quantities from the new finite-range droplet model FRDM(2012)

      SciTech Connect

      Kratz, Karl-Ludwig; Farouqi, Khalil; Möller, Peter E-mail: kfarouqi@lsw.uni-heidelberg.de

      2014-09-01

      Attempts to explain the source of r-process elements in our solar system (S.S.) by particular astrophysical sites still face entwined uncertainties, stemming from the extrapolation of nuclear properties far from stability, inconsistent sources of different properties (e.g., nuclear masses and β-decay properties), and the poor understanding of astrophysical conditions, which are hard to disentangle. In this paper we present results from the investigation of r-process in the high-entropy wind (HEW) of core-collapse supernovae (here chosen as one of the possible scenarios for this nucleosynthesis process), using new nuclear-data input calculated in a consistent approach, for masses and β-decay properties from the new finite-range droplet model FRDM(2012). The accuracy of the new mass model is 0.56 MeV with respect to AME2003, to which it was adjusted. We compare the new HEW r-process abundance pattern to the latest S.S. r-process residuals and to our earlier calculations with the nuclear-structure quantities based on FRDM(1992). Substantial overall and specific local improvements in the calculated pattern of the r-process between A ≅ 110 and {sup 209}Bi, as well as remaining deficiencies, are discussed in terms of the underlying spherical and deformed shell structure far from stability.

    10. Large-scale evaluation of β -decay rates of r -process nuclei with the inclusion of first-forbidden transitions

      NASA Astrophysics Data System (ADS)

      Marketin, T.; Huther, L.; Martínez-Pinedo, G.

      2016-02-01

      Background: r -process nucleosynthesis models rely, by necessity, on nuclear structure models for input. Particularly important are β -decay half-lives of neutron-rich nuclei. At present only a single systematic calculation exists that provides values for all relevant nuclei making it difficult to test the sensitivity of nucleosynthesis models to this input. Additionally, even though there are indications that their contribution may be significant, the impact of first-forbidden transitions on decay rates has not been systematically studied within a consistent model. Purpose: Our goal is to provide a table of β -decay half-lives and β -delayed neutron emission probabilities, including first-forbidden transitions, calculated within a fully self-consistent microscopic theoretical framework. The results are used in an r -process nucleosynthesis calculation to asses the sensitivity of heavy element nucleosynthesis to weak interaction reaction rates. Method: We use a fully self-consistent covariant density functional theory (CDFT) framework. The ground state of all nuclei is calculated with the relativistic Hartree-Bogoliubov (RHB) model, and excited states are obtained within the proton-neutron relativistic quasiparticle random phase approximation (p n -RQRPA). Results: The β -decay half-lives, β -delayed neutron emission probabilities, and the average number of emitted neutrons have been calculated for 5409 nuclei in the neutron-rich region of the nuclear chart. We observe a significant contribution of the first-forbidden transitions to the total decay rate in nuclei far from the valley of stability. The experimental half-lives are in general well reproduced for even-even, odd-A , and odd-odd nuclei, in particular for short-lived nuclei. The resulting data table is included with the article as Supplemental Material. Conclusions: In certain regions of the nuclear chart, first-forbidden transitions constitute a large fraction of the total decay rate and must be taken into account consistently in modern evaluations of half-lives. Both the β -decay half-lives and β -delayed neutron emission probabilities have a noticeable impact on the results of heavy element nucleosynthesis models.

    11. Activation of α7 nicotinic receptor affects APP processing by regulating secretase activity in SH-EP1-α7 nAChR-hAPP695 cells.

      PubMed

      Nie, Hui Zhen; Shi, Sha; Lukas, Ronald J; Zhao, Wen Juan; Sun, Yong Ning; Yin, Ming

      2010-10-14

      Multiple lines of evidence have implicated that nicotinic acetylcholine receptor (nAChR) may be an important therapeutic target for the treatment of Alzheimer's disease (AD). Although there are reports suggesting a link between alpha7 nAChR subtype and AD, there has been little report on the mechanism. The present study investigates whether and how α7 nAChR activation affects APP695 processing in SH-EP1 cell model. Cell line co-expressing α7 nAChR gene and human amyloid precursor protein 695 (hAPP695) gene were constructed by stable transfection. Expression of β-amyloid, α-form of secreted APP (αAPPs) and APP1695 was measured by ELISA, western blotting and real-time PCR respectively. Additionally, α, β, and γ-secretase activities were also analyzed in constructed SH-EP1-α7 nAChR-hAPP695 cell line. The results showed that SH-EP1-α7 nAChR-hAPP695 cell line, expressing both hAPP695 gene and α7 nAChR subtype gene, was constructed successfully. The secreted Aβ was decreased and αAPPs was significantly increased by non-selective nAChR agonist nicotine (10 μM) and specific α7 nAChR agonist GTS-21 (1 μM), and APP expression was not affected. Furthermore, specific α7 nAChR antagonist methyllycaconitine (MLA) reversed the alterations induced by activation of α7 nAChR. CTF-α was increased and CTF-γ was decreased when treated with nicotine (10 μM). In addition, the results of enymatic activity analysis showed that nicotine (1μM) and GTS-21 (0.1, 1 μM) decreased γ-secretase activity, but has no effects on α-secretase activity and β-secretase activity. Our findings demonstrate that, through regulating γ-secretase activity, α7 nAChR activation reduces APP processing in amyloidogenic pathway, and at the same time enhances APP processing in non-amyloidogenic pathway. The constructed SH-EP1-α7 nAChR-hAPP695 cell line might be useful for screening specific nAChR agonists against AD. PMID:20708605

    12. atBRX1-1 and atBRX1-2 are involved in an alternative rRNA processing pathway in Arabidopsis thaliana.

      PubMed

      Weis, Benjamin L; Palm, Denise; Missbach, Sandra; Bohnsack, Markus T; Schleiff, Enrico

      2015-03-01

      Ribosome biogenesis is an essential process in all organisms. In eukaryotes, multiple ribosome biogenesis factors (RBFs) act in the processing of ribosomal (r)RNAs, assembly of ribosomal subunits and their export to the cytoplasm. We characterized two genes in Arabidopsis thaliana coding for orthologs of yeast BRX1, a protein involved in maturation of the large ribosomal subunit. Both atBRX1 proteins, encoded by AT3G15460 and AT1G52930, respectively, are mainly localized in the nucleolus and are ubiquitously expressed throughout plant development and in various tissues. Mutant plant lines for both factors show a delay in development and pointed leaves can be observed in the brx1-2 mutant, implying a link between ribosome biogenesis and plant development. In addition, the pre-rRNA processing is affected in both mutants. Analysis of the pre-rRNA intermediates revealed that early processing steps can occur either in the 5' external transcribed spacer (ETS) or internal transcribed spacer 1 (ITS1). Interestingly, we also find that in xrn2 mutants, early processing events can be bypassed and removal of the 5' ETS is initiated by cleavage at the P' processing site. While the pathways of pre-rRNA processing are comparable to those of yeast and mammalian cells, the balance between the two processing pathways is different in plants. Furthermore, plant-specific steps such as an additional processing site in the 5' ETS, likely post-transcriptional processing of the early cleavage sites and accumulation of a 5' extended 5.8S rRNA not observed in other eukaryotes can be detected. PMID:25605960

    13. Kilonovae: Electromagnetic Counterparts of Neutron Star Mergers Powered by the Radioactive Decay of R-Process Nuclei

      NASA Astrophysics Data System (ADS)

      Metzger, Brian

      2014-03-01

      The coalescence of binary neutron stars (NSs) are the most promising sources for the direct detection of gravitational waves by Advanced LIGO and Virgo. However, maximizing the scientific opportunities from such a discovery will require the detection of a coincident electromagnetic counterpart. One possible counterpart is a short gamma-ray burst (GRB), powered by the accretion of NS debris left over from the merger onto the newly-formed black hole. However, GRBs are thought to be relativistically beamed and hence to accompany only a small fraction of mergers. NS mergers also produce isotropic supernova-like emission, powered by the radioactive decay of heavy (r-process) elements which are synthesized in the neutron-rich ejecta from the merger. I will describe the first calculations of such ``kilonovae'' which include realistic nuclear physics and radiative transport. In addition to providing a smoking gun for detecting binary NS mergers, kilonovae inform the unknown origin of the heaviest elements in the Universe. The first kilonova may have been discovered by the Hubble Space Telescope last year.

    14. Shelf Edge Exchange Processes-2: Seep2-02, R/V CAPE HATTERAS cruise CH01-88

      SciTech Connect

      Wilson, C.; Behrens, W.J.; Flagg, C.N.; Wallace, D.W.R.; Wilke, R.J.; Wyman, K.D.

      1989-11-01

      The R/V CAPE HATTERAS cruise CH01-88, SEEP2-02, took place from 3--20 March, 1988 and focused primarily on biological processes in the SEEP2 area. A short term sediment trap mooring was deployed near mooring 1 and recovered during the cruise. The mooring consisted of two 0.07 sq. meter and one 0.7 sq. meter sediment traps. Two time series, approximately 48 hours each, were conducted in the area of the sediment trap mooring. The time series were designed to study primary and secondary productivity and involved sampling nutrients, dissolved oxygen, chlorophyll, zooplankton abundance and distribution, and zooplankton fecal pellet distribution. Experiments to estimate grazing rates and fecal pellet production of the dominant copepods were also done. Sediment trap and zooplankton data are not reported here. During this cruise 99 CTD casts were made measuring pressure, temperature, conductivity, dissolved oxygen, fluorescence and light transmission. Discrete samples were taken in rosette-mounted Niskin bottles and analyzed for concentration of nutrients, chlorophyll a, dissolved oxygen, and particulate organic carbon and nitrogen.

    15. Preparation and modification of VO2 thin film on R-sapphire substrate by rapid thermal process

      NASA Astrophysics Data System (ADS)

      Zhu, Nai-Wei; Hu, Ming; Xia, Xiao-Xu; Wei, Xiao-Ying; Liang, Ji-Ran

      2014-04-01

      The VO2 thin film with high performance of metal-insulator transition (MIT) is prepared on R-sapphire substrate for the first time by magnetron sputtering with rapid thermal process (RTP). The electrical characteristic and THz transmittance of MIT in VO2 film are studied by four-point probe method and THz time domain spectrum (THz-TDS). X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), atomic force microscopy (AFM), and search engine marketing (SEM) are employed to analyze the crystalline structure, valence state, surface morphology of the film. Results indicate that the properties of VO2 film which is oxidized from the metal vanadium film in oxygen atmosphere are improved with a follow-up RTP modification in nitrogen atmosphere. The crystallization and components of VO2 film are improved and the film becomes compact and uniform. A better phase transition performance is shown that the resistance changes nearly 3 orders of magnitude with a 2-C hysteresis width and the THz transmittances are reduced by 64% and 60% in thermal and optical excitation respectively.

    16. Formerly Used Sites Remedial Action Program (FUSRAP) W. R. Grace Feasibility Study (FS) Alternative Development Process Challenges And Successes

      SciTech Connect

      Fatherly, N.; O'Neill, M.; Glemza, A.

      2008-07-01

      Monazite sand processing was conducted at the W. R. Grace Curtis Bay Facility (Baltimore, Maryland) in the mid 1950's under contract to the Atomic Energy Commission (AEC), for the extraction of source material in the form of thorium, as well as rare earth elements. The processing was conducted in the southwest quadrant of a five-story building (Building 23) in the active manufacturing portion of the facility. Building components and equipment in the southwest quadrant of Building 23 exhibit residual radiological activity remaining from the monazite sand processing. Waste materials from the processing operations (termed gangue) were disposed in the non-manufacturing portion of the facility, in the area referred to the Radioactive Waste Disposal Area (RWDA). Approximately 19,880 cubic meters (m{sup 3}) of radioactive gangue was buried within the RWDA. Waste was believed to be buried at various depths up to 2.7 meters (m), and possibly as deep as 7.6 m. The RI and a supplemental investigation have been completed for the RWDA and adjacent boundary areas. A Feasibility Study (FS) to address residual radioactivity in soils at the RWDA is in the process of being finalized. The chemical-specific Applicable, Relevant, and Appropriate Requirement (ARAR) was selected for the FUSRAP contaminants, and Remedial Goals (RGs) were calculated for the cleanup. The RGs were developed based upon guidance provided in the selected ARAR, 10 Code of Federal Regulations (CFR) 40, Appendix A, Criterion 6(6). This standard is designed to provide an acceptable level of protection to the average member of a critical group who may be exposed to radium in soil for a given scenario. Scenarios, critical group members, and RGs were established in consultation with stakeholders. Dose assessment calculations were performed in accordance with the ARAR to establish derived concentration guideline levels (DCGLs) for each radionuclide in the 232-Thorium ({sup 232}Th) and 238-Uranium ({sup 238}U) chain for both surface and subsurface soils. A sum of the ratios calculation (also called the unity rule) will be utilized (with the DCGLs) to assure compliance with the benchmark doses associated with the radium standards. Six alternatives (including no action) were considered in the FS and included the following technologies: soil washing, segregation, capping/covering, excavation/disposal, and site restrictions. A bench scale study was conducted by USACE to assess the efficacy of soil washing at the site. Results of the study showed reduction of radiological activity in soil. Segregation can be implemented using traditional sampling/analytical routines or automated (gate) segregation and it is likely to reduce the waste stream by at least 30%, while providing a more complete characterization of the soil with a particularly high level of confidence. Challenges for the FS phase of the project included: managing stakeholder input and expectations, defining separate and distinct alternatives for the FS in accordance with the CERCLA process, and selecting the most appropriate ARARs. The challenges were handled successfully, and USACE is finalizing a robust document acceptable to the stakeholders, which will allow USACE to meet the program milestone. In summary: Conducting the W.R. Grace FUSRAP site FUSRAP process has been challenging from a project management perspective, due in part to the nature and extent of impact at the site (residual radioactivity; active processing building and disposal area) and incorporating site owner involvement in the process. Through the use of mediation and mutual commitment to the project by both parties, USACE and the site owner were able to find agreement on fundamental issues and set a firm foundation for achieving successful remedial action and site closure using a 'forward thinking' approach. Currently, USACE is finalizing the RWDA FS to address contamination in soils at the RWDA. ARARs have been identified and selected as per CERCLA guidance. Although obstacles were encountered, the challenges were handled successfully, and USACE is finalizing a robust document acceptable to the site owner, the regulators, and the public, which will allow USACE to move forward successfully in the FUSRAP program. (authors)

    17. Mutant p53 induces EZH2 expression and promotes epithelial-mesenchymal transition by disrupting p68-Drosha complex assembly and attenuating miR-26a processing.

      PubMed

      Jiang, Fei-Zhou; He, Yin-Yan; Wang, Hui-Hui; Zhang, Hui-Lin; Zhang, Jian; Yan, Xiao-Fang; Wang, Xiao-Jun; Che, Qi; Ke, Jie-Qi; Chen, Zheng; Tong, Huan; Zhang, Yong-Li; Wang, Fang-Yuan; Li, Yi-Ran; Wan, Xiao-Ping

      2015-12-29

      The tumor suppressor p53 and the transcriptional repressor Enhancer of Zeste Homolog 2 (EZH2) have both been implicated in the regulation of epithelial-mesenchymal transition (EMT) and tumor metastasis via their impacts on microRNA expression. Here, we report that mutant p53 (mutp53) promotes EMT in endometrial carcinoma (EC) by disrupting p68-Drosha complex assembly. Overexpression of mutp53 has the opposite effect of wild-type p53 (WTp53), repressing miR-26a expression by reducing pri-miR-26a-1 processing in p53-null EC cells. Re-expression of miR-26a in mutp53 EC cells decreases cell invasion and promotes mesenchymal-epithelial transition (MET). Rescuing miR-26a expression also inhibits EZH2, N-cadherin, Vimentin, and Snail expression and induces E-cadherin expression both in vitro and in vivo. Moreover, patients with higher serum miR-26a levels have a better survival rate. These results suggest that p53 gain-of-function mutations accelerate EC tumor progression and metastasis by interfering with Drosha and p68 binding and pri-miR-26a-1 processing, resulting in reduced miR-26a expression and EZH2 overexpression. PMID:26587974

    18. Mutant p53 induces EZH2 expression and promotes epithelial–mesenchymal transition by disrupting p68-Drosha complex assembly and attenuating miR-26a processing

      PubMed Central

      Wang, Hui-Hui; Zhang, Hui-Lin; Zhang, Jian; Yan, Xiao-Fang; Wang, Xiao-Jun; Che, Qi; Ke, Jie-Qi; Chen, Zheng; Tong, Huan; Zhang, Yong-Li; Wang, Fang-Yuan; Li, Yi-Ran; Wan, Xiao-Ping

      2015-01-01

      The tumor suppressor p53 and the transcriptional repressor Enhancer of Zeste Homolog 2 (EZH2) have both been implicated in the regulation of epithelial-mesenchymal transition (EMT) and tumor metastasis via their impacts on microRNA expression. Here, we report that mutant p53 (mutp53) promotes EMT in endometrial carcinoma (EC) by disrupting p68-Drosha complex assembly. Overexpression of mutp53 has the opposite effect of wild-type p53 (WTp53), repressing miR-26a expression by reducing pri-miR-26a-1 processing in p53-null EC cells. Re-expression of miR-26a in mutp53 EC cells decreases cell invasion and promotes mesenchymal-epithelial transition (MET). Rescuing miR-26a expression also inhibits EZH2, N-cadherin, Vimentin, and Snail expression and induces E-cadherin expression both in vitro and in vivo. Moreover, patients with higher serum miR-26a levels have a better survival rate. These results suggest that p53 gain-of-function mutations accelerate EC tumor progression and metastasis by interfering with Drosha and p68 binding and pri-miR-26a-1 processing, resulting in reduced miR-26a expression and EZH2 overexpression. PMID:26587974

    19. miR-503 represses CUG-binding protein 1 translation by recruiting CUGBP1 mRNA to processing bodies

      PubMed Central

      Cui, Yu-Hong; Xiao, Lan; Rao, Jaladanki N.; Zou, Tongtong; Liu, Lan; Chen, Yu; Turner, Douglas J.; Gorospe, Myriam; Wang, Jian-Ying

      2012-01-01

      microRNAs (miRNAs) and RNA-binding proteins (RBPs) jointly regulate gene expression at the posttranscriptional level and are involved in many aspects of cellular functions. The RBP CUG-binding protein 1 (CUGBP1) destabilizes and represses the translation of several target mRNAs, but the exact mechanism that regulates CUGBP1 abundance remains elusive. In this paper, we show that miR-503, computationally predicted to associate with three sites of the CUGBP1 mRNA, represses CUGBP1 expression. Overexpression of an miR-503 precursor (pre-miR-503) reduced the de novo synthesis of CUGBP1 protein, whereas inhibiting miR-503 by using an antisense RNA (antagomir) enhanced CUGBP1 biosynthesis and elevated its abundance; neither intervention changed total CUGBP1 mRNA levels. Studies using heterologous reporter constructs revealed a greater repressive effect of miR-503 through the CUGBP1 coding region sites than through the single CUGBP1 3?-untranslated region target site. CUGBP1 mRNA levels in processing bodies (P-bodies) increased in cells transfected with pre-miR-503, while silencing P-body resident proteins Ago2, RCK, or LSm4 decreased miR-503mediated repression of CUGBP1 expression. Decreasing the levels of cellular polyamines reduced endogenous miR-503 levels and promoted CUGBP1 expression, an effect that was prevented by ectopic miR-503 overexpression. Repression of CUGBP1 by miR-503 in turn altered the expression of CUGBP1 target mRNAs and thus increased the sensitivity of intestinal epithelial cells to apoptosis. These findings identify miR-503 as both a novel regulator of CUGBP1 expression and a modulator of intestinal epithelial homoeostasis. PMID:22072795

    20. X-ray decay lines from heavy nuclei in supernova remnants as a probe of the r-process origin and the birth periods of magnetars

      NASA Astrophysics Data System (ADS)

      Ripley, Justin L.; Metzger, Brian D.; Arcones, Almudena; Martínez-Pinedo, Gabriel

      2014-03-01

      The origin of rapid neutron capture (r-process) nuclei remains one of the longest standing mysteries in nuclear astrophysics. Core collapse supernovae (SNe) and neutron star binary mergers are likely r-process sites, but little evidence yet exists for their in situ formation in such environments. Motivated by the advent of sensitive new or planned X-ray telescopes such as the Nuclear Spectroscopic Telescope Array (NuSTAR) and the Large Observatory for X-ray Timing (LOFT), we revisit the prospects for the detection of X-ray decay lines from r-process nuclei in young or nearby supernova remnants. For all remnants planned to be observed by NuSTAR (and several others), we conclude that r-process nuclei are detectable only if the remnant possesses a large overabundance O ≳ 10^3 relative to the average yield per SN. Prospects are better for the next Galactic SN (assumed age of 3 yr and distance of 10 kpc), for which an average r-process yield is detectable via the 10.7 (9.2) keV line complexes of 194Os by LOFT at 6σ (5σ) confidence; the 27.3 keV line complex of 125Sb is detectable by NuSTAR at 2σ for O ≳ 2. We also consider X-rays lines from the remnants of Galactic magnetars, motivated by the much higher r-process yields of the magnetorotationally driven SNe predicted to birth magnetars. The ˜3.6-3.9 keV lines of 126Sn are potentially detectable in the remnants of the magnetars 1E1547.0-5408 and 1E2259+586 by LOFT for an assumed r-process yield predicted by recent simulations. The (non-)detection of these lines can thus probe whether magnetars are indeed born with millisecond periods. Finally, we consider a blind survey of the Galactic plane with LOFT for r-process lines from the most recent binary neutron star merger remnant, concluding that a detection is unlikely without additional information on the merger location.

    1. Theoretical uncertainty of (α ,n ) reactions relevant for the nucleosynthesis of light r -process nuclei in neutrino-driven winds

      NASA Astrophysics Data System (ADS)

      Pereira, J.; Montes, F.

      2016-03-01

      Background: Neutrino-driven winds following core-collapse supernova explosions have been proposed as a possible site where light r -process nuclei (between Fe and Ag) might be synthesized. In these events, (α ,n ) reactions are key to moving matter towards the region of higher proton number. Abundance network calculations are very sensitive to the rates for this type of reactions. Purpose: The present work aims at evaluating the theoretical uncertainty of these (α ,n ) reactions calculated with reaction codes based on the Hauser-Feshbach model. Method: We compared several (α ,n ) rates taken from talys and the non-smoker database to determine the uncertainties owing to the existing technical differences between both codes. In addition, we evaluated the sensitivity of talys rates to variations in the α optical potentials, masses, level densities, optical potentials, preequilibrium intranuclear transition rates, level structure, radiative transmission coefficients, and width-fluctuation correction factors. Results: The main source of uncertainty at low temperature is mostly attributable to the use of different α optical potentials. Differences between talys and non-smoker at high temperatures arise from the energy-binning algorithm used by each code. We have also noticed that the (α ,n ) rates from the non-smoker database correspond to the inclusive reaction, instead of the exclusive (α ,1 n ) channel calculated in the present work and used in network calculations. Conclusions: Theoretical uncertainties in calculated reaction rates can be as high as one to two orders of magnitude and strongly dependent on the temperature of the environment. Besides direct measurements of the inclusive and exclusive (α ,1 n ) reaction rates, experimental studies of α optical potentials are crucial to improve the performance of reaction codes.

    2. A plant snoRNP complex containing snoRNAs, fibrillarin, and nucleolin-like proteins is competent for both rRNA gene binding and pre-rRNA processing in vitro.

      PubMed

      Sáez-Vasquez, Julio; Caparros-Ruiz, David; Barneche, Fredy; Echeverría, Manuel

      2004-08-01

      In eukaryotes the primary cleavage of the precursor rRNA (pre-rRNA) occurs in the 5' external transcribed spacer (5'ETS). In Saccharomyces cerevisiae and animals this cleavage depends on a conserved U3 small nucleolar ribonucleoprotein particle (snoRNP), including fibrillarin, and on other transiently associated proteins such as nucleolin. This large complex can be visualized by electron microscopy bound to the nascent pre-rRNA soon after initiation of transcription. Our group previously described a radish rRNA gene binding activity, NF D, that specifically binds to a cluster of conserved motifs preceding the primary cleavage site in the 5'ETS of crucifer plants including radish, cauliflower, and Arabidopsis thaliana (D. Caparros-Ruiz, S. Lahmy, S. Piersanti, and M. Echeverria, Eur. J. Biochem. 247:981-989, 1997). Here we report the purification and functional characterization of NF D from cauliflower inflorescences. Remarkably NF D also binds to 5'ETS RNA and accurately cleaves it at the primary cleavage site mapped in vivo. NF D is a multiprotein factor of 600 kDa that dissociates into smaller complexes. Two polypeptides of NF D identified by microsequencing are homologues of nucleolin and fibrillarin. The conserved U3 and U14 snoRNAs associated with fibrillarin and required for early pre-rRNA cleavages are also found in NF D. Based on this it is proposed that NF D is a processing complex that assembles on the rDNA prior to its interaction with the nascent pre-rRNA. PMID:15282326

    3. S2P3-R (v1.0): a framework for efficient regional modelling of physical and biological structures and processes in shelf seas

      NASA Astrophysics Data System (ADS)

      Marsh, R.; Hickman, A. E.; Sharples, J.

      2015-10-01

      An established one-dimensional (1-D) model of Shelf Sea Physics and Primary Production (S2P3) is adapted for flexible use in selected regional settings over selected periods of time. This Regional adaptation of S2P3, the S2P3-R framework (v1.0), can be efficiently used to investigate physical and biological phenomena in shelf seas that are strongly controlled by vertical processes. These include spring blooms that follow the onset of stratification, tidal mixing fronts that seasonally develop at boundaries between mixed and stratified water, and sub-surface chlorophyll maxima that persist throughout summer. While not representing 3-D processes, S2P3-R reveals the horizontal variation of the key 1-D (vertical) processes. S2P3-R should therefore only be used in regions where horizontal processes - including mean flows, eddy fluxes and internal tides - are known to exert a weak influence in comparison with vertical processes. In such cases, S2P3-R may be used as a highly versatile research tool, alongside more complex and computationally expensive models. In undergraduate oceanography modules and research projects, the model serves as an effective practical tool for linking theory and field observations. Three different regional configurations of S2P3-R are described, illustrating a range of diagnostics, evaluated where practical with observations. The model can be forced with daily meteorological variables for any selected year in the reanalysis era (1948 onwards). Example simulations illustrate the considerable extent of synoptic-to-interannual variability in the physics and biology of shelf seas. In discussion, the present limitations of S2P3-R are emphasised, and future developments are outlined.

    4. Examining the cross-cultural sensitivity of the Revised Two-Factor Study Process Questionnaire (R-SPQ-2F) and validation of a Dutch version.

      PubMed

      Stes, Ann; De Maeyer, Sven; Van Petegem, Peter

      2013-01-01

      The Revised Two-Factor Study Process Questionnaire (R-SPQ-2F) is used to examine students' study approaches in higher education. The questionnaire assumes to measure two factors: a deep and a surface study approach. Analyses into the validity and reliability of the original English R-SPQ-2F yielded positive results. In this study, we examined the degree to which these positive results can also be found for the Dutch version that we developed. By comparing our results with the results of earlier studies in different cultures, we conclude cross-cultural sensitivity is an important point to be borne in mind when using the R-SPQ-2F. Our research supports the validity and reliability of our Dutch version of the R-SPQ-2F. PMID:23342085

    5. Examining the Cross-Cultural Sensitivity of the Revised Two-Factor Study Process Questionnaire (R-SPQ-2F) and Validation of a Dutch Version

      PubMed Central

      Stes, Ann; De Maeyer, Sven; Van Petegem, Peter

      2013-01-01

      The Revised Two-Factor Study Process Questionnaire (R-SPQ-2F) is used to examine students’ study approaches in higher education. The questionnaire assumes to measure two factors: a deep and a surface study approach. Analyses into the validity and reliability of the original English R-SPQ-2F yielded positive results. In this study, we examined the degree to which these positive results can also be found for the Dutch version that we developed. By comparing our results with the results of earlier studies in different cultures, we conclude cross-cultural sensitivity is an important point to be borne in mind when using the R-SPQ-2F. Our research supports the validity and reliability of our Dutch version of the R-SPQ-2F. PMID:23342085

    6. Novel processing in a mammalian nuclear 28S pre-rRNA: tissue-specific elimination of an 'intron' bearing a hidden break site.

      PubMed Central

      Melen, G J; Pesce, C G; Rossi, M S; Kornblihtt, A R

      1999-01-01

      Splitting and apparent splicing of ribosomal RNA, both previously unknown in vertebrates, were found in rodents of the genus Ctenomys. Instead of being formed by a single molecule of 4.4 kb, 28S rRNA is split in two molecules of 2.6 and 1.8 kb. A hidden break, mapping within a 106 bp 'intron' located in the D6 divergent region, is expressed in mature ribosomes of liver, lung, heart and spleen, as well as in primary fibroblast cultures. Testis-specific processing eliminates the intron and concomitantly the break site, producing non-split 28S rRNA molecules exclusively in this organ. The intron is flanked by two 9 bp direct repeats, revealing the acquisition by insertion of a novel rRNA processing strategy in the evolution of higher organisms. PMID:10357822

    7. β decay of nuclei around 90Se: Search for signatures of a N=56 subshell closure relevant to the r process

      NASA Astrophysics Data System (ADS)

      Quinn, M.; Aprahamian, A.; Pereira, J.; Surman, R.; Arndt, O.; Baumann, T.; Becerril, A.; Elliot, T.; Estrade, A.; Galaviz, D.; Ginter, T.; Hausmann, M.; Hennrich, S.; Kessler, R.; Kratz, K.-L.; Lorusso, G.; Mantica, P. F.; Matos, M.; Montes, F.; Pfeiffer, B.; Portillo, M.; Schatz, H.; Schertz, F.; Schnorrenberger, L.; Smith, E.; Stolz, A.; Walters, W. B.; Wöhr, A.

      2012-03-01

      Background: Nuclear structure plays a significant role on the rapid neutron capture process (r process) since shapes evolve with the emergence of shells and subshells. There was some indication in neighboring nuclei that we might find examples of a new N=56 subshell, which may give rise to a doubly magic 3490Se56 nucleus.Purpose: β-decay half-lives of nuclei around 90Se have been measured to determine if this nucleus has in fact a doubly magic character.Method: The fragmentation of a 136Xe beam at the National Superconducting Cyclotron Laboratory at Michigan State University was used to create a cocktail of nuclei in the A=90 region.Results: We have measured the half-lives of 22 nuclei near the r-process path in the A=90 region. The half-lives of 88As and 90Se have been measured for the first time. The values were compared with theoretical predictions in the search for nuclear-deformation signatures of a N=56 subshell, and its possible role in the emergence of a potential doubly magic 90Se. The impact of such hypothesis on the synthesis of heavy nuclei, particularly in the production of Sr, Y, and Zr elements was investigated with a weak r-process network.Conclusions: The new half-lives agree with results obtained from a standard global QRPA model used in r-process calculations, indicating that 90Se has a quadrupole shape incompatible with a closed N=56 subshell in this region. The impact of the measured 90Se half-life in comparison with a former theoretical predication associated with a spherical half-life on the weak r process is shown to be strong.

    8. The Revised Two-Factor Study Process Questionnaire (R-SPQ-2F): Exploratory and Confirmatory Factor Analyses at Item Level

      ERIC Educational Resources Information Center

      Justicia, Fernando; Pichardo, M. Carmen; Cano, Francisco; Berben, A. B. G.; De la Fuente, Jesus

      2008-01-01

      The underlying structure of the Revised Two Factor version of the Study Process Questionnaire (R-SPQ-2F), a 20-item instrument for the evaluation of students' approaches to learning (SAL), was examined at item level using two independent groups of undergraduate students enrolled in the first (n = 314) and last (n = 522) years of their studies. The…

    9. Corrigendum to "The impact of individual nuclear properties on r-process nucleosynthesis" [J. Prog. Part. Nucl. Phys. 86C (2015) 86-126

      NASA Astrophysics Data System (ADS)

      Mumpower, M. R.; Surman, R.; McLaughlin, G. C.; Aprahamian, A.

      2016-03-01

      The authors regret that the scale of the far right axis of Fig. 1 was incorrect. The scale of the far right axis of Fig. 1, indicating the evolution of density with time for a cold r-process trajectory, has been corrected. There is no change to the figure caption.

    10. NVL2, a nucleolar AAA-ATPase, is associated with the nuclear exosome and is involved in pre-rRNA processing

      SciTech Connect

      Yoshikatsu, Yuki; Ishida, Yo-ichi; Sudo, Haruka; Yuasa, Keizo; Tsuji, Akihiko; Nagahama, Masami

      2015-08-28

      Nuclear VCP-like 2 (NVL2) is a member of the chaperone-like AAA-ATPase family and is involved in the biosynthesis of 60S ribosomal subunits in mammalian cells. We previously showed the interaction of NVL2 with a DExD/H-box RNA helicase MTR4/DOB1, which is a known cofactor for an exoribonuclease complex, the exosome. This finding implicated NVL2 in RNA metabolic processes during ribosome biogenesis. In the present study, we found that a series of mutations within the ATPase domain of NVL2 causes a defect in pre-rRNA processing into mature 28S and 5.8S rRNAs. Co-immunoprecipitation analysis showed that NVL2 was associated with the nuclear exosome complex, which includes RRP6 as a nucleus-specific catalytic subunit. This interaction was prevented by depleting either MTR4 or RRP6, indicating their essential role in mediating this interaction with NVL2. Additionally, knockdown of MPP6, another cofactor for the nuclear exosome, also prevented the interaction by causing MTR4 to dissociate from the nuclear exosome. These results suggest that NVL2 is involved in pre-rRNA processing by associating with the nuclear exosome complex and that MPP6 is required for maintaining the integrity of this rRNA processing complex. - Highlights: • ATPase-deficient mutants of NVL2 have decreased pre-rRNA processing. • NVL2 associates with the nuclear exosome through interactions with MTR4 and RRP6. • MPP6 stabilizes MTR4-RRP6 interaction and allows NVL2 to interact with the complex.

    11. miR-181b as a key regulator of the oncogenic process and its clinical implications in cancer (Review)

      PubMed Central

      LIU, JUAN; SHI, WEIFENG; WU, CHANGPING; JU, JINGFANG; JIANG, JINGTING

      2014-01-01

      MicroRNAs (miRNAs or miRs) are small, non-coding, single-stranded RNA molecules that regulate gene expression at the post-transcriptional level to repress protein expression of target genes. Among these, miR-181b has been found to be a critical regulatory miRNA linking inflammation and cancer. The functional significance of miR-181b in various tumors and translational research suggests that it exhibits great potential as a predictive and prognostic biomarker. Extensive efforts are underway to identify mRNA targets and the affected regulatory networks, which may be the key to providing a better understanding of miR-181b-mediated signaling pathways. PMID:24649060

    12. Comparative MicroRNA Expression Profiles of Cynomolgus Monkeys, Rat, and Human Reveal that miR-182 Is Involved in T2D Pathogenic Processes

      PubMed Central

      Zhou, Jinghui; Meng, Yuhuan; Tian, Shuai; Liu, Mingyu; Zhuo, Min; Zhang, Yu; Wang, Xiaoning

      2014-01-01

      Type 2 diabetes (T2D) is a prevalent disease that happens around the world and usually happens with insulin resistance. MicroRNAs (miRNAs) represented important roles in the suppression of gene expression and were proven to be related to human diseases. In this study, we used cynomolgus monkey fed with normal and high fatty diet (HFD), respectively, to analyze the miRNA expression profile in whole blood by deep sequencing. Finally in total 24 miRNAs with differential expression were filtered. Among them, miR-182 related to the insulin resistance by modulating FOXO1 and PI3K/AKT cascade and had the greatest copy number in the whole blood. Decrease of miR-182 in T2D cynomolgus individuals is completely consistent with the previous studies in human and rat. Integrating miR-182 tissue expression profile, target genes, and copy number in blood reveals that miR-182 plays a key role in crucial genes modulation, such as FOXO1 and BHLHE22, which leads to potential hyperglycemia and modulates the insulin secretion. In addition, miR-182 might regulate the processes of both cell proliferation and apoptosis that play crucial role in determining the cells' fate. Therefore, miR-182 can be a biomarker in diagnosis of the potential T2D that has benefits for medical purpose. PMID:25530976

    13. A novel "oxygen-induced" greening process in a cyanobacterial mutant lacking the transcriptional activator ChlR involved in low-oxygen adaptation of tetrapyrrole biosynthesis.

      PubMed

      Aoki, Rina; Hiraide, Yuto; Yamakawa, Hisanori; Fujita, Yuichi

      2014-01-17

      ChlR activates the transcription of the chlAII-ho2-hemN operon in response to low-oxygen conditions in the cyanobacterium Synechocystis sp. PCC 6803. Three genes in the operon encode low-oxygen-type enzymes to bypass three oxygen-dependent reactions in tetrapyrrole biosynthesis. A chlR-lacking mutant, ΔchlR, shows poor photoautotrophic growth due to low chlorophyll (Chl) content under low-oxygen conditions, which is caused by no induction of the operon. Here, we characterized the processes of etiolation of ΔchlR cells in low-oxygen conditions and the subsequent regreening of the etiolated cells upon exposure to oxygen, by HPLC, Western blotting, and low-temperature fluorescence spectra. The Chl content of the etiolated ΔchlR cells incubated under low-oxygen conditions for 7 days was only 10% of that of the wild-type with accumulation of almost all intermediates of the magnesium branch of Chl biosynthesis. Both photosystem I (PSI) and photosystem II (PSII) were significantly decreased, accompanied by a preferential decrease of antenna Chl in PSI. Upon exposure to oxygen, the etiolated ΔchlR cells resumed to produce Chl after a short lag (∼2 h), and the level at 72 h was 80% of that of the wild-type. During this novel "oxygen-induced" greening process, the PSI and PSII contents were largely increased in parallel with the increase in Chl contents. After 72 h, the PSI content reached ∼50% of the wild-type level in contrast to the full recovery of PSII. ΔchlR provides a promising alternative system to investigate the biogenesis of PSI and PSII. PMID:24297184

    14. ACToR Chemical Structure processing using Open Source ChemInformatics Libraries (FutureToxII)

      EPA Science Inventory

      ACToR (Aggregated Computational Toxicology Resource) is a centralized database repository developed by the National Center for Computational Toxicology (NCCT) at the U.S. Environmental Protection Agency (EPA). Free and open source tools were used to compile toxicity data from ove...

    15. Oligomers, protofibrils and amyloid fibrils from recombinant human lysozyme (rHL): fibrillation process and cytotoxicity evaluation for ARPE-19 cell line.

      PubMed

      Ruiz, Eva D; Almada, Mario; Burboa, María G; Taboada, Pablo; Mosquera, Víctor; Valdez, Miguel A; Juárez, Josué

      2015-02-01

      Amyloid-associated diseases, such Alzheimer's, Huntington's, Parkinson's, and type II diabetes, are related to protein misfolding and aggregation. Herein, the time evolution of scattered light intensity, hydrophobic properties, and conformational changes during fibrillation processes of rHL solutions at 55 °C and pH 2.0 were used to monitor the aggregation process of recombinant human lysozyme (rHL). Dynamic light scattering (DLS), thioflavin T (ThT) fluorescence, and surface tension (ST) at the air-water interface were used to analyze the hydrophobic properties of pre-amyloid aggregates involved in the fibrillation process of rHL to find a correlation between the hydrophobic character of oligomers, protofibrils and amyloid aggregates with the gain in cross-β-sheet structure, depending on the increase in the incubation periods. The ability of the different aggregates of rHL isolated during the fibrillation process to be adsorbed at the air-water interface can provide important information about the hydrophobic properties of the protein, which can be related to changes in the secondary structure of rHL, resulting in cytotoxic or non-cytotoxic species. Thus, we evaluated the cytotoxic effect of oligomers, protofibrils and amyloid fibrils on the cell line ARPE-19 using the MTT reduction test. The more cytotoxic protein species arose after a 600-min incubation time, suggesting that the hydrophobic character of pre-amyloid fibrils, in addition to the high prevalence of the cross-β-sheet conformation, can become toxic for the cell line ARPE-19. PMID:25618793

    16. Laser Remote Measurements of atmospheric pollutants (Las-R-Map): UV-Visible Laser system description and data processing

      NASA Astrophysics Data System (ADS)

      Sivakumar, V.; Wyk, H. V.

      Laser radar more popularly known as LIDAR LIght Detection And Ranging is becoming one of the most powerful techniques for active remote sensing of the earth s atmosphere Around the globe several new lidar systems have been developed based on the scientific interest Particularly the DIfferential Absorption Lidar DIAL technique is only one which can provide the better accuracy of measuring atmospheric pollutants Using modern advanced techniques and instrumentation a mobile DIAL system called laser remote measurements of atmospheric pollutants hear after referred as Las-R-Map is designed at National Laser Centre NLC --Pretoria 25 r 45 prime S 28 r 17 prime E Las-R-Map is basically used for measuring atmospheric pollutants applying the principle of absorption by constituents The system designed primarily to focus on the following pollutant measurements such as SO 2 CH 4 CO 2 NO 2 and O 3 In future the system could be used to measure few particulate matter between 2 5 mu m and 10 mu m Benzene Hg 1 3-butadiene H 2 S HF and Volatile Organic Compounds VOC Las-R-map comprises of two different laser sources Alexandrite and CO 2 optical receiver data acquisition and signal processor It uses alexandrite laser in the UV-Visible region from 200 nm to 800 nm and CO 2 laser in the Far-IR region from 9 2 mu m to 10 8 mu m Such two different laser sources make feasibility for studying the wide range of atmospheric pollutants The present paper is focused on technical details

    17. An autoregulatory network between menin and pri-miR-24-1 is required for the processing of its specific modulator miR-24-1 in BON1 cells.

      PubMed

      Luzi, Ettore; Marini, Francesca; Ciuffi, Simone; Galli, Gianna; Brandi, Maria Luisa

      2016-05-24

      Multiple endocrine neoplasia type 1 (MEN1) is a rare hereditary cancer complex syndrome manifesting a variety of endocrine and non-endocrine neoplasms and lesions. MEN1 is characterized by tumours of the parathyroids, of the neuroendocrine cells of the gastroenteropancreatic tract, and of the anterior pituitary. The MEN1 gene, a tumour suppressor gene, encodes the menin protein. Loss of heterozygosity (LOH) at 11q13 is typical of MEN1 tumours in agreement with Knudson's two-hit hypothesis. We previously showed that the MEN1 parathyroid tumorigenesis is under the control of an "incoherent feedback loop" between miR-24-1 and the menin protein that generates a "Gene Regulatory Network" (GRN) that mimics the second hit of Knudson's hypothesis and that could buffer the effect of the stochastic factors that contribute to the onset and progression of this disease. Here we show, in the BON1 cell line derived from lymphnode metastasis of a human carcinoid tumour of the pancreas, that menin binds specifically to the primary RNA sequence pri-miR-24-1 by promoting the miR-24-1 biogenesis. Network simulation showed a new feed-forward loop between menin, microRNA-24-1 and Musashi-1 proteins. This result shows a novel mechanism whereby menin, a RNA-binding protein, facilitates the processing of its specific miRNA by regulating the dynamics of the menin-miR-24 Gene Regulatory Network at the level of pri-miRNA processing. PMID:27098433

    18. {sup 13,14}B(n, γ) via Coulomb Dissociation for Nucleosynthesis towards the r-Process

      SciTech Connect

      Altstadt, S.G.; Adachi, T.; Aksyutina, Y.; Alcantara, J.; Alvarez-Pol, H.; Ashwood, N.; Atar, L.; Aumann, T.; Avdeichikov, V.; Barr, M.; Beceiro, S.; Bemmerer, D.; and others

      2014-06-15

      Radioactive beams of {sup 14,15}B produced by fragmentation of a primary {sup 40}Ar beam were directed onto a Pb target to investigate the neutron breakup within the Coulomb field. The experiment was performed at the LAND/R{sup 3}B setup. Preliminary results for the Coulomb dissociation cross sections as well as for the astrophysically interesting inverse reactions, {sup 13,14}B(n,γ), are presented.

    19. Mycobacterium bovis BCG Interferes with miR-3619-5p Control of Cathepsin S in the Process of Autophagy

      PubMed Central

      Pawar, Kamlesh; Sharbati, Jutta; Einspanier, Ralf; Sharbati, Soroush

      2016-01-01

      Main survival mechanism of pathogenic mycobacteria is to escape inimical phagolysosomal environment inside the macrophages. Many efforts have been made to unravel the molecular mechanisms behind this process. However, little is known about the involvement of microRNAs (miRNAs) in the regulation of phagolysosomal biosynthesis and maturation. Based on a bottom up approach, we searched for miRNAs that were involved in phagolysosomal processing events in the course of mycobacterial infection of macrophages. After infecting THP-1 derived macrophages with viable and heat killed Mycobacterium bovis BCG (BCG), early time points were identified after co-localization studies of the phagosomal marker protein LAMP1 and BCG. Differences in LAMP1 localization on the phagosomes of both groups were observed at 30 min and 4 h. After in silico based pre-selection of miRNAs, expression analysis at the identified time points revealed down-regulation of three miRNAs: miR-3619-5p, miR-637, and miR-324-3p. Consequently, most likely targets were predicted that were supposed to be mutually regulated by these three studied miRNAs. The lysosomal cysteine protease Cathepsin S (CTSS) and Rab11 family-interacting protein 4 (RAB11FIP4) were up-regulated and were considered to be connected to lysosomal trafficking and autophagy. Interaction studies verified the regulation of CTSS by miR-3619-5p. Down-regulation of CTSS by ectopic miR-3619-5p as well as its specific knockdown by siRNA affected the process of autophagy in THP-1 derived macrophages. PMID:27014637

    20. Aggregation of Ribosomal Protein S6 at Nucleolus Is Cell Cycle-Controlled and Its Function in Pre-rRNA Processing Is Phosphorylation Dependent.

      PubMed

      Zhang, Duo; Chen, Hui-Peng; Duan, Hai-Feng; Gao, Li-Hua; Shao, Yong; Chen, Ke-Yan; Wang, You-Liang; Lan, Feng-Hua; Hu, Xian-Wen

      2016-07-01

      Ribosomal protein S6 (rpS6) has long been regarded as one of the primary r-proteins that functions in the early stage of 40S subunit assembly, but its actual role is still obscure. The correct forming of 18S rRNA is a key step in the nuclear synthesis of 40S subunit. In this study, we demonstrate that rpS6 participates in the processing of 30S pre-rRNA to 18S rRNA only when its C-terminal five serines are phosphorylated, however, the process of entering the nucleus and then targeting the nucleolus does not dependent its phosphorylation. Remarkably, we also find that the aggregation of rpS6 at the nucleolus correlates to the phasing of cell cycle, beginning to concentrate in the nucleolus at later S phase and disaggregate at M phase. J. Cell. Biochem. 117: 1649-1657, 2016. © 2015 Wiley Periodicals, Inc. PMID:26639987

    1. Compact Ku-Band T/R Module for High-Resolution Radar Imaging of Cold Land Processes

      NASA Technical Reports Server (NTRS)

      Andricos, Constantine; Yueh, Simon H.; Krimskiy, Vladimir A.; Rahmat-Samii, Yahya

      2010-01-01

      Global measurement of terrestrial snow cover is critical to two of the NASA Earth Science focus areas: (1) climate variability and change and (2) water and energy cycle. For radar backscatter measurements, Ku-band frequencies, scattered mainly within the volume of the snowpack, are most suitable for the SWE (snow-water equivalent) measurements. To isolate the complex effects of different snowpack (density and snowgrain size), and underlying soil properties and to distinctly determine SWE, the space-based synthetic aperture radar (SAR) system will require a dual-frequency (13.4 and 17.2 GHz) and dual polarization approach. A transmit/receive (T/R) module was developed operating at Ku-band frequencies to enable the use of active electronic scanning phased-array antenna for wide-swath, high-resolution SAR imaging of terrestrial snow cover. The T/R module has an integrated calibrator, which compensates for all environmental- and time-related changes, and results in very stable power and amplitude characteristics. The module was designed to operate over the full frequency range of 13 to 18 GHz, although only the two frequencies, 13.4 GHz and 17.2 GHz, will be used in this SAR radar application. Each channel of the transmit module produces > 4 W (35 dbm) over the operating bandwidth of 20 MHz. The stability requirements of <0.1 dB receive gain accuracy and <0.1 dB transmit power accuracy over a wide temperature range are achieved using a self-correction scheme, which does real-time amplitude calibration so that the module characteristics are continually corrected. All the calibration circuits are within the T/R module. The timing and calibration sequence is stored in a control FPGA (field-programmable gate array) while an internal 128K 8bit high-speed RAM (random access memory) stores all the calibration values. The module was designed using advanced components and packaging techniques to achieve integration of the electronics in a 2 x6.5x1-in. (5x17x2.5-cm) package. The module size allows 4 T/R modules to feed the 16 16-element subarray on an antenna panel. The T/R module contains four transmit channels and eight receive channels (horizontal and vertical polarizations).

    2. An end-to-end system in support of a broad scope of GOES-R sensor and data processing study

      NASA Astrophysics Data System (ADS)

      Huang, Hung-Lung

      2005-08-01

      The mission of NOAA's Geostationary Operational Environmental Satellite System (GOES) R series satellites, in the 2012 time frame, is to provide continuous, near real-time meteorological, oceanographic, solar, and space environment data that supports NOAA's strategic mission goals. It presents an exciting opportunity to explore new instruments, satellite designs, and system architectures utilizing new communication and instrument technologies in order to meet the ever-increasing demands made of Earth observation systems by national agencies and end users alike. The GOES-R sensor suite includes a 16 spectral band Advanced Baseline Imager (ABI), an approximately 1500 high spectral resolution band Hyperspectral Environmental Suite (HES), plus other sensors designed to detect lightning and to explore the ocean, solar and space environment. The Cooperative Institute for Meteorological Satellite Studies (CIMSS) as part of the Space Science and Engineering Center (SSEC) of the University of Wisconsin-Madison, the long time partner of NOAA, has developed the first operational end-to-end processing system for GOES. Based on this heritage, and with recent support from the NASA/NOAA Geosynchrous Imaging FTS (GIFTS) project, the Navy's Multiple University Research Initiative (MURI), and NOAA's GOES-R Risk Reduction program, SSEC has built a near-complete end-to-end system that is capable of simulating sensor measurements from top of atmosphere radiances, raw sensor data (level 0) through calibrated and navigated sensor physical measurements (level 1) to the processed products (level 2). In this paper, the SSEC Hyperspectral Imaging and Sounding Simulator and Processor (HISSP) will be presented in detail. HISSP is capable of demonstrating most of the processing functions such as data compression/decompression, sensor calibration, data processing, algorithm development, and product generation. In summary, HISSP is an end-to-end system designed to support both government and industry for the GOES-R system and their related broad scope of acquisition activities.

    3. β -Decay Half-Lives of 110 Neutron-Rich Nuclei across the N =82 Shell Gap: Implications for the Mechanism and Universality of the Astrophysical r Process

      NASA Astrophysics Data System (ADS)

      Lorusso, G.; Nishimura, S.; Xu, Z. Y.; Jungclaus, A.; Shimizu, Y.; Simpson, G. S.; Söderström, P.-A.; Watanabe, H.; Browne, F.; Doornenbal, P.; Gey, G.; Jung, H. S.; Meyer, B.; Sumikama, T.; Taprogge, J.; Vajta, Zs.; Wu, J.; Baba, H.; Benzoni, G.; Chae, K. Y.; Crespi, F. C. L.; Fukuda, N.; Gernhäuser, R.; Inabe, N.; Isobe, T.; Kajino, T.; Kameda, D.; Kim, G. D.; Kim, Y.-K.; Kojouharov, I.; Kondev, F. G.; Kubo, T.; Kurz, N.; Kwon, Y. K.; Lane, G. J.; Li, Z.; Montaner-Pizá, A.; Moschner, K.; Naqvi, F.; Niikura, M.; Nishibata, H.; Odahara, A.; Orlandi, R.; Patel, Z.; Podolyák, Zs.; Sakurai, H.; Schaffner, H.; Schury, P.; Shibagaki, S.; Steiger, K.; Suzuki, H.; Takeda, H.; Wendt, A.; Yagi, A.; Yoshinaga, K.

      2015-05-01

      The β -decay half-lives of 110 neutron-rich isotopes of the elements from Rb 37 to Sn 50 were measured at the Radioactive Isotope Beam Factory. The 40 new half-lives follow robust systematics and highlight the persistence of shell effects. The new data have direct implications for r -process calculations and reinforce the notion that the second (A ≈130 ) and the rare-earth-element (A ≈160 ) abundance peaks may result from the freeze-out of an (n ,γ )⇄(γ ,n ) equilibrium. In such an equilibrium, the new half-lives are important factors determining the abundance of rare-earth elements, and allow for a more reliable discussion of the r process universality. It is anticipated that universality may not extend to the elements Sn, Sb, I, and Cs, making the detection of these elements in metal-poor stars of the utmost importance to determine the exact conditions of individual r -process events.

    4. The nuclear physics input to astrophysics modelling, and the r- and p-processes: Where do we stand 50 years after B^2FH and Cameron?

      NASA Astrophysics Data System (ADS)

      Arnould, M.

      2008-11-01

      This is a brief review of the progress made since the seminal contributions to the foundations of the theory of nucleosynthesis by M. Burbidge, G. Burbidge, Fowler and Hoyle, and by Cameron. The reviewed topics are (1) the nuclear physics input to the nucleosynthesis models (nuclear masses, fission, rates of β-decays, neutrino reactions, photoreactions, and nuclear charged particle-induced or neutron-induced reactions), (2) the nuclear physics and astrophysics aspects of the r-process, and (3) the same items for the p-process.

    5. First stars. XV. Third-peak r-process element and actinide abundances in the uranium-rich star CS31082-001

      NASA Astrophysics Data System (ADS)

      Barbuy, B.; Spite, M.; Hill, V.; Primas, F.; Plez, B.; Cayrel, R.; Spite, F.; Wanajo, S.; Siqueira Mello, C.; Andersen, J.; Nordström, B.; Beers, T. C.; Bonifacio, P.; François, P.; Molaro, P.

      2011-10-01

      Context. A small fraction of extremely metal-poor (EMP) stars exhibit moderate to extreme excesses of heavy neutron-capture elements produced in the r-process. The production site(s) of these elements in the early Galaxy remain(s) unclear, as is the reason for their occasional enhancement in the otherwise regular pattern of abundances of elements up to the iron peak. The detailed abundance pattern of the heaviest elements in EMP stars provides insight into their origin and role in the chemical enrichment of the early Galaxy and in radioactive nucleochronology. Aims: The EMP giant star CS 31082-001 ([Fe/H] ~ -2.9) exhibits an extreme enhancement of neutron-capture elements ([r/Fe] ~ +1.7) with U and Th enhanced by a further ~+0.7 dex, and a minimum of blending by molecular lines such as CH or CN. A rich inventory of r-process element abundances was established previously from optical spectra. Here we aim to supplement these data with abundances from near-UV spectroscopy of the third-peak neutron-capture elements, which are crucial for understanding the synthesis of the heaviest elements. Methods: Near-UV spectra from HST/STIS were analysed with LTE model atmospheres and spectrum synthesis calculations to derive new abundances of Os, Ir, Pt, Au, Bi and Pb in CS 31082-001. Results: Together with earlier data, the resulting abundance pattern for the r-process elements provides improved constraints on the nature of the r-process. The observed U and Th abundances and the initial production ratio place CS 31082-001 as one of the oldest stars in the Galaxy, consistent with its extreme metal deficiency. Comparison with the heaviest stable reference elements and with the daughter nuclides Pb and Bi provides a consistency check on this age determination. Finally, the existence of such r-element rich stars indicate that the early chemical evolution of the Galaxy was localised and inhomogeneous. Based on observations made with the NASA/ESA Hubble Space Telescope (HST) through the Space Telescope Science Institute, operated by the Association of Universities for Research in Astronomy, Inc., under NASA contract NAS5-26555; and with the ESO Very Large Telescope at Paranal Observatory, Chile; Progr. ID 165.N-0276.

    6. MEMBRANE-MODERATED STRIPPING PROCESS FOR REMOVING VOCS FROM WATER IN A COMPOSITE HOLLOW FIBER MODULE. (R825511C027)

      EPA Science Inventory

      The "stripmeation" process for removing volatile organic compounds (VOCs) from water has been introduced and studied. An aqueous solution of the VOC is passed through the bores of hydrophobic microporous polypropylene hollow fibers having a plasma polymerized silicone ...

    7. Explaining the Ba, Y, Sr, and Eu abundance scatter in metal-poor halo stars: constraints to the r-process

      NASA Astrophysics Data System (ADS)

      Cescutti, G.; Chiappini, C.

      2014-05-01

      Context. Thanks to the heroic observational campaigns carried out in recent years we now have large samples of metal-poor stars for which measurements of detailed abundances exist. In particular, large samples of stars with metallicities -5 < [Fe/H] <-1 and measured abundances of Sr, Ba, Y, and Eu are now available. These data hold important clues on the nature of the contribution of the first stellar generations to the enrichment of our Galaxy. Aims: We aim to explain the scatter in Sr, Ba, Y, and Eu abundance ratio diagrams unveiled by the metal-poor halo stars. Methods: We computed inhomogeneous chemical evolution models for the Galactic halo assuming different scenarios for the r-process site: the electron-capture (EC) supernovae and the magnetorotationally driven (MRD) supernovae scenarios. We also considered models with and without the contribution of fast-rotating massive stars (spinstars) to an early enrichment by the s-process. A detailed comparison with the now large sample of stars with measured abundances of Sr, Ba, Y, Eu, and Fe is provided (both in terms of scatter plots and number distributions for several abundance ratios). Results: The scatter observed in these abundance ratios of the very metal-poor stars (with [Fe/H] <-2.5) can be explained by combining the s-process production in spinstars, and the r-process contribution coming from massive stars. For the r-process we have developed models for both the EC and the MRD scenarios that match the observations. Conclusions: With the present observational and theoretical constraints we cannot distinguish between the EC and the MRD scenarios in the Galactic halo. Independently of the r-process scenarios adopted, the production of elements by an s-process in spinstars is needed to reproduce the spread in abundances of the light neutron capture elements (Sr and Y) over heavy neutron capture elements (Ba and Eu). We provide a way to test our suggestions by means of the distribution of the Ba isotopic ratios in a [Ba/Fe] or [Sr/Ba] vs. [Fe/H] diagram. Appendix A is available in electronic form at http://www.aanda.org

    8. Low-Frequency Repetitive Transcranial Magnetic Stimulation (rTMS) Affects Event-Related Potential Measures of Novelty Processing in Autism

      PubMed Central

      Baruth, Joshua; Tasman, Allan; Mansoor, Mehreen; Ramaswamy, Rajesh; Sears, Lonnie; Mathai, Grace; El-Baz, Ayman; Casanova, Manuel F.

      2009-01-01

      In our previous study on individuals with autism spectrum disorder (ASD) (Sokhadze et al., Appl Psychophysiol Biofeedback 34:37–51, 2009a) we reported abnormalities in the attention-orienting frontal event-related potentials (ERP) and the sustained-attention centro-parietal ERPs in a visual oddball experiment. These results suggest that individuals with autism over-process information needed for the successful differentiation of target and novel stimuli. In the present study we examine the effects of low-frequency, repetitive Transcranial Magnetic Stimulation (rTMS) on novelty processing as well as behavior and social functioning in 13 individuals with ASD. Our hypothesis was that low-frequency rTMS application to dorsolateral prefrontal cortex (DLFPC) would result in an alteration of the cortical excitatory/inhibitory balance through the activation of inhibitory GABAergic double bouquet interneurons. We expected to find post-TMS differences in amplitude and latency of early and late ERP components. The results of our current study validate the use of low-frequency rTMS as a modulatory tool that altered the disrupted ratio of cortical excitation to inhibition in autism. After rTMS the parieto-occipital P50 amplitude decreased to novel distracters but not to targets; also the amplitude and latency to targets increased for the frontal P50 while decreasing to non-target stimuli. Low-frequency rTMS minimized early cortical responses to irrelevant stimuli and increased responses to relevant stimuli. Improved selectivity in early cortical responses lead to better stimulus differentiation at later-stage responses as was made evident by our P3b and P3a component findings. These results indicate a significant change in early, middle-latency and late ERP components at the frontal, centro-parietal, and parieto-occipital regions of interest in response to target and distracter stimuli as a result of rTMS treatment. Overall, our preliminary results show that rTMS may prove to be an important research tool or treatment modality in addressing the stimulus hypersensitivity characteristic of autism spectrum disorders. PMID:19941058

    9. Ferromanganese nodules from MANOP Sites H, S, and R-Control of mineralogical and chemical composition by multiple accretionary processes

      USGS Publications Warehouse

      Dymond, J.; Lyle, M.; Finney, B.; Piper, D.Z.; Murphy, K.; Conard, R.; Pisias, N.

      1984-01-01

      The chemical composition of ferromanganese nodules from the three nodule-bearing MANOP sites in the Pacific can be accounted for in a qualitative way by variable contributions of distinct accretionary processes. These accretionary modes are: 1. (1) hydrogenous, i.e., direct precipitation or accumulation of colloidal metal oxides in seawater, 2. (2) oxic diagenesis which refers to a variety of ferromanganese accretion processes occurring in oxic sediments; and 3. (3) suboxic diagenesis which results from reduction of Mn+4 by oxidation of organic matter in the sediments. Geochemical evidence suggests processes (1) and (2) occur at all three MANOP nodule-bearing sites, and process (3) occurs only at the hemipelagic site, H, which underlies the relatively productive waters of the eastern tropical Pacific. A normative model quantitatively accounts for the variability observed in nearly all elements. Zn and Na, however, are not well explained by the three end-member model, and we suggest that an additional accretionary process results in greater variability in the abundances of these elements. Variable contributions from the three accretionary processes result in distinct top-bottom compositional differences at the three sites. Nodule tops from H are enriched in Ni, Cu, and Zn, instead of the more typical enrichments of these elements in nodule bottoms. In addition, elemental correlations typical of most pelagic nodules are reversed at site H. The three accretionary processes result in distinct mineralogies. Hydrogenous precipitation produces ??MnO2. Oxic diagenesis, however, produces Cu-Ni-rich todorokite, and suboxic diagenesis results in an unstable todorokite which transforms to a 7 A?? phase ("birnessite") upon dehydration. The presence of Cu and Ni as charge-balancing cations influence the stability of the todorokite structure. In the bottoms of H nodules, which accrete dominantly by suboxic diagenesis, Na+ and possibly Mn+2 provide much of the charge balance for the todorokite structure. Limited growth rate data for H nodules suggest suboxic accretion is the fastest of the three processes, with rates at least 200 mm/106 yr. Oxic accretion is probably 10 times slower and hydrogenous 100 times slower. Since these rates predict more suboxic component in bulk nodules than is calculated by the normative analysis, we propose that suboxic accretion is a non-steady-state process. Variations in surface water productivity cause pulses of particulate flux to the sea floor which result in transient Mn reduction in the surface sediments and reprecipitation on nodule surfaces. ?? 1984.

    10. Novel Magnetically Fluidized Bed Reactor Development for the Looping Process: Coal to Hydrogen Production R&D

      SciTech Connect

      Mei, Renwei; Hahn, David; Klausner, James; Petrasch, Jorg; Mehdizadeh, Ayyoub; Allen, Kyle; Rahmatian, Nima; Stehle, Richard; Bobek, Mike; Al-Raqom, Fotouh; Greek, Ben; Li, Like; Chen, Chen; Singh, Abhishek; Takagi, Midori; Barde, Amey; Nili, Saman

      2013-09-30

      The coal to hydrogen project utilizes the iron/iron oxide looping process to produce high purity hydrogen. The input energy for the process is provided by syngas coming from gasification process of coal. The reaction pathways for this process have been studied and favorable conditions for energy efficient operation have been identified. The Magnetically Stabilized Porous Structure (MSPS) is invented. It is fabricated from iron and silica particles and its repeatable high performance has been demonstrated through many experiments under various conditions in thermogravimetric analyzer, a lab-scale reactor, and a large scale reactor. The chemical reaction kinetics for both oxidation and reduction steps has been investigated thoroughly inside MSPS as well as on the surface of very smooth iron rod. Hydrogen, CO, and syngas have been tested individually as the reducing agent in reduction step and their performance is compared. Syngas is found to be the most pragmatic reducing agent for the two-step water splitting process. The transport properties of MSPS including porosity, permeability, and effective thermal conductivity are determined based on high resolution 3D CT x-ray images obtained at Argonne National Laboratory and pore-level simulations using a lattice Boltzmann Equation (LBE)-based mesoscopic model developed during this investigation. The results of those measurements and simulations provide necessary inputs to the development of a reliable volume-averaging-based continuum model that is used to simulate the dynamics of the redox process in MSPS. Extensive efforts have been devoted to simulate the redox process in MSPS by developing a continuum model consist of various modules for conductive and radiative heat transfer, fluid flow, species transport, and reaction kinetics. Both the Lagrangian and Eulerian approaches for species transport of chemically reacting flow in porous media have been investigated and verified numerically. Both approaches lead to correct prediction of hydrogen production rates over a large range of experimental conditions in the laboratory scale reactor and the bench-scale reactor. In the economic analysis, a comparison of the hydrogen production plants using iron/iron oxide looping cycle and the conventional process has been presented. Plant configurations are developed for the iron/iron oxide looping cycle. The study suggests a higher electric power generation but a lower hydrogen production efficiency comparing with the conventional process. Additionally, it was shown that the price of H{sub 2} obtained from our reactor can be as low as $1.7/kg, which is 22% lower than the current price of the H{sub 2} obtained from reforming plants.

    11. Static and fatigue testing of full-scale fuselage panels fabricated using a Therm-X(R) process

      NASA Technical Reports Server (NTRS)

      Dinicola, Albert J.; Kassapoglou, Christos; Chou, Jack C.

      1992-01-01

      Large, curved, integrally stiffened composite panels representative of an aircraft fuselage structure were fabricated using a Therm-X process, an alternative concept to conventional two-sided hard tooling and contour vacuum bagging. Panels subsequently were tested under pure shear loading in both static and fatigue regimes to assess the adequacy of the manufacturing process, the effectiveness of damage tolerant design features co-cured with the structure, and the accuracy of finite element and closed-form predictions of postbuckling capability and failure load. Test results indicated the process yielded panels of high quality and increased damage tolerance through suppression of common failure modes such as skin-stiffener separation and frame-stiffener corner failure. Finite element analyses generally produced good predictions of postbuckled shape, and a global-local modelling technique yielded failure load predictions that were within 7% of the experimental mean.

    12. Static and fatigue testing of full-scale fuselage panels fabricated using a Therm-X(R) process

      SciTech Connect

      Dinicola, A.J.; Kassapoglou, C.; Chou, J.C.

      1992-09-01

      Large, curved, integrally stiffened composite panels representative of an aircraft fuselage structure were fabricated using a Therm-X process, an alternative concept to conventional two-sided hard tooling and contour vacuum bagging. Panels subsequently were tested under pure shear loading in both static and fatigue regimes to assess the adequacy of the manufacturing process, the effectiveness of damage tolerant design features co-cured with the structure, and the accuracy of finite element and closed-form predictions of postbuckling capability and failure load. Test results indicated the process yielded panels of high quality and increased damage tolerance through suppression of common failure modes such as skin-stiffener separation and frame-stiffener corner failure. Finite element analyses generally produced good predictions of postbuckled shape, and a global-local modelling technique yielded failure load predictions that were within 7% of the experimental mean.

    13. A KINETIC MODEL FOR H2O2/UV PROCESS IN A COMPLETELY MIXED BATCH REACTOR. (R825370C076)

      EPA Science Inventory

      A dynamic kinetic model for the advanced oxidation process (AOP) using hydrogen peroxide and ultraviolet irradiation (H2O2/UV) in a completely mixed batch reactor (CMBR) is developed. The model includes the known elementary chemical and photochemical reac...

    14. Report on the Analysis of Some Process-Oriented Curricula. An Annotated Listing. Program Report R101.

      ERIC Educational Resources Information Center

      Bernstein, Susan; And Others

      This report contains 20 summary-descriptions of curriculum programs and materials selected by the Institute for possible inclusion in its synthesis and validation of a K-6 process-promoting curriculum. Each description includes information on the developer and publisher plus a list of references (mostly published descriptions and critiques).…

    15. INVESTIGATION OF AQUEOUS BIPHASIC SYSTEMS FOR THE SEPARATIONS OF LIGNINS FROM CELLULOSE IN THE PAPER PULPING PROCESS. (R826732)

      EPA Science Inventory

      In efforts to apply a polymer-based aqueous biphasic system (ABS) extraction to the paper pulping process, the study of the distribution of various lignin and cellulosic fractions in ABS and the effects of temperature on system composition and solute partitioning have been inv...

    16. The Relationship of Teacher Perceptions to Classroom Processes and Student Outcomes. R&D Rep. No. 6109.

      ERIC Educational Resources Information Center

      Clements, Barbara S.

      Considerable research has been done relating measures of teacher personality or attitudes to classroom behaviors, pupil achievement, and pupil attitudes. The major purpose of these studies has been to identify patterns of classroom behaviors, attitudes, concerns, and conceptual processes which characterize teachers. Fifty-one junior high teachers…

    17. HST/STIS abundances in the uranium rich metal poor star CS 31082-001: Constraints on the r-Process

      NASA Astrophysics Data System (ADS)

      Siqueira-Mello, C.; Spite, M.; Barbuy, B.; Spite, F.; Caffau, E.; Hill, V.; Wanajo, S.; Primas, F.; Plez, B.; Cayrel, R.; Andersen, J.; Nordström, B.; Sneden, C.; Beers, T. C.; Bonifacio, P.; François, P.; Molaro, P.

      2016-01-01

      As a brief revision, the origin of heavy elements and the role of abundances in extremely metal-poor (EMP) stars are presented. Heavy element abundances in the EMP uranium-rich star CS 31082-001 based mainly on near-UV spectra from STIS/HST are presented. These results should be useful for a better characterisation of the neutron exposure(s) that produced the r-process elements in this star, as well as a guide for improving nuclear data and astrophysical site modelling, given that the new element abundances not available in previous works (Ge, Mo, Lu, Ta, W, Re, Pt, Au, and Bi) make CS 31082-001 the most completely well studied r-II object, with a total of 37 detections of n-capture elements.

    18. NOL11, Implicated in the Pathogenesis of North American Indian Childhood Cirrhosis, Is Required for Pre-rRNA Transcription and Processing

      PubMed Central

      Freed, Emily F.; Prieto, Jos-Luis; McCann, Kathleen L.; McStay, Brian; Baserga, Susan J.

      2012-01-01

      The fundamental process of ribosome biogenesis requires hundreds of factors and takes place in the nucleolus. This process has been most thoroughly characterized in baker's yeast and is generally well conserved from yeast to humans. However, some of the required proteins in yeast are not found in humans, raising the possibility that they have been replaced by functional analogs. Our objective was to identify non-conserved interaction partners for the human ribosome biogenesis factor, hUTP4/Cirhin, since the R565W mutation in the C-terminus of hUTP4/Cirhin was reported to cause North American Indian childhood cirrhosis (NAIC). By screening a yeast two-hybrid cDNA library derived from human liver, and through affinity purification followed by mass spectrometry, we identified an uncharacterized nucleolar protein, NOL11, as an interaction partner for hUTP4/Cirhin. Bioinformatic analysis revealed that NOL11 is conserved throughout metazoans and their immediate ancestors but is not found in any other phylogenetic groups. Co-immunoprecipitation experiments show that NOL11 is a component of the human ribosomal small subunit (SSU) processome. siRNA knockdown of NOL11 revealed that it is involved in the cleavage steps required to generate the mature 18S rRNA and is required for optimal rDNA transcription. Furthermore, abnormal nucleolar morphology results from the absence of NOL11. Finally, yeast two-hybrid analysis shows that NOL11 interacts with the C-terminus of hUTP4/Cirhin and that the R565W mutation partially disrupts this interaction. We have therefore identified NOL11 as a novel protein required for the early stages of ribosome biogenesis in humans. Our results further implicate a role for NOL11 in the pathogenesis of NAIC. PMID:22916032

    19. Process innovation in high-performance systems: From polymeric composites R&D to design and build of airplane showers

      NASA Astrophysics Data System (ADS)

      Wu, Yi-Jui

      In the aerospace industry reducing aircraft weight is key because it increases flight performance and drives down operating costs. With fierce competition in the commercial aircraft industry, companies that focused primarily on exterior aircraft performance design issues are turning more attention to the design of aircraft interior. Simultaneously, there has been an increase in the number of new amenities offered to passengers especially in first class travel and executive jets. These new amenities present novel and challenging design parameters that include integration into existing aircraft systems without sacrificing flight performance. The objective of this study was to design a re-circulating shower system for an aircraft that weighs significantly less than pre-existing shower designs. This was accomplished by integrating processes from polymeric composite materials, water filtration, and project management. Carbon/epoxy laminates exposed to hygrothermal cycling conditions were evaluated and compared to model calculations. Novel materials and a variety of fabrication processes were developed to create new types of paper for honeycomb applications. Experiments were then performed on the properties and honeycomb processability of these new papers. Standard water quality tests were performed on samples taken from the re-circulating system to see if current regulatory standards were being met. These studies were executed and integrated with tools from project management to design a better shower system for commercial aircraft applications.

    20. Shelf edge exchange processes-II SEEP2-06, R/V Endeavor cruise 186. Hydrographic data report

      SciTech Connect

      Wilson, C.; Behrens, W.J.; Flagg, C.N.; Wallace, D.W.R.; Wilke, R.J.; Wyman, K.D.

      1989-12-01

      The Shelf Edge Exchange Processes (SEEP) program sponsored by the United States Department of Energy is a multi-institutional effort designed to investigate the flux of suspended material from the continental shelf to the waters of the upper slope, and then possibly into the slope sediments. Phase I of SEEP consisted of a series of nine cruises and a mooring array across the outer continental shelf of New England during 1983--1984. Phase II focused specifically on the shelf/slope frontal region of the mid-Atlantic bight off the Delmarva Peninsula. Hydrographic data were collected on eight of the six cruises.

    1. r.avaflow: An advanced open source computational framework for the GIS-based simulation of two-phase mass flows and process chains

      NASA Astrophysics Data System (ADS)

      Mergili, Martin; Fischer, Jan-Thomas; Fellin, Wolfgang; Ostermann, Alexander; Pudasaini, Shiva P.

      2015-04-01

      Geophysical mass flows stand for a broad range of processes and process chains such as flows and avalanches of snow, soil, debris or rock, and their interactions with water bodies resulting in flood waves. Despite considerable efforts put in model development, the simulation, and therefore the appropriate prediction of these types of events still remains a major challenge in terms of the complex material behaviour, strong phase interactions, process transformations and the complex mountain topography. Sophisticated theories exist, but they have hardly been brought to practice yet. We fill this gap by developing a novel and unified high-resolution computational tool, r.avaflow, representing a comprehensive and advanced open source GIS simulation environment for geophysical mass flows. Based on the latest and most advanced two-phase physical-mathematical models, r.avaflow includes the following features: (i) it is suitable for a broad spectrum of mass flows such as rock, rock-ice and snow avalanches, glacial lake outburst floods, debris and hyperconcentrated flows, and even landslide-induced tsunamis and submarine landslides, as well as process chains involving more than one of these phenomena; (ii) it accounts for the real two-phase nature of many flow types: viscous fluids and solid particles are considered separately with advanced mechanics and strong phase interactions; (iii) it is freely available and adoptable along with the GRASS GIS software. In the future, it will include the intrinsic topographic influences on the flow dynamics and morphology as well as an advanced approach to simulate the entrainment and deposition of solid and fluid material. As input r.avaflow needs information on (a) the mountain topography, (b) the material properties and (c) the spatial distribution of the solid and fluid release masses or one or more hydrographs of fluid and solid material. We demonstrate the functionalities and performance of r.avaflow by using some generic and real-world examples including a channelized debris flow with hydrograph input, and a rock avalanche impacting a reservoir, triggering a flood wave overtopping and eroding the dam. Project web site: http://www.avaflow.org/

    2. Beta-decay half-lives and beta-delayed neutron emisison probabilities of nuclei in the region A. 110, relevant for the r-process

      SciTech Connect

      Moller, Peter; Pereira, J; Hennrich, S; Aprahamian, A; Arndt, O; Becerril, A; Elliot, T; Estrade, A; Galaviz, D; Kessler, R; Kratz, K - L; Lorusso, G; Mantica, P F; Matos, M; Montes, F; Pfeiffer, B; Schatz, F; Schnorrenberger, L; Smith, E; Stolz, A; Quinn, M; Walters, W B; Wohr, A

      2009-01-01

      Measurements of the {beta}-decay properties of A {approx}< 110 r-process nuclei have been completed at the National Superconducting Cyclotron Laboratory, at Michigan State University. {beta}-decay half-lives for {sup 105}Y, {sup 106,107}Zr and {sup 108,111}Mo, along with ,B-delayed neutron emission probabilities of 104Y, 109,11OMo and upper limits for 105Y, 103-107Zr and 108,111 Mo have been measured for the first time. Studies on the basis of the quasi-random phase approximation are used to analyze the ground-state deformation of these nuclei.

    3. Shelf Edge Exchange Processes, II: SEEP2-08, R/V ENDEAVOR cruise 188. Hydrographic data report

      SciTech Connect

      Wilson, C.; Behrens, W.J.; Flagg, C.N.; Wallace, D.W.R.; Wilke, R.J.; Wyman, K.D.

      1989-12-01

      The Shelf Edge Exchange Processes (SEEP) program sponsored by the United States Department of Energy is a multi-institutional effort designed to investigate the flux of suspended material from the continental shelf to the waters of the upper slope, and then possibly into the slope sediments. Phase I of SEEP consisted of a series of nine cruises and a mooring array across the outer continental shelf of New England during 1983--1984 (Behrens and Flagg, 1986). Phase II focused specifically on the shelf/slope frontal region of the mid-Atlantic bight off the Delmarva Peninsula. This project consisted of a series of ten cruises, a mooring array, and a series of over-flights by NASA aircraft. Hydrographic data were collected on eight of the cruises, six of which were primarily mooring deployment or recovery cruises. The cruises were consecutively designated SEEP2-01 to SEEP2-10. Two cruises (SEEP2-04 and SEEP2-07) were dedicated to investigating benthic processes and hydrographic data were not collected.

    4. Chemogenomic Study of Carboplatin in Saccharomyces cerevisiae: Inhibition of the NEDDylation Process Overcomes Cellular Resistance Mediated by HuR and Cullin Proteins

      PubMed Central

      Custodio, Débora Fernandes; Freitas, Vanessa Morais; Monteiro, Gisele

      2015-01-01

      The use of carboplatin in cancer chemotherapy is limited by the emergence of drug resistance. To understand the molecular basis for this resistance, a chemogenomic screen was performed in 53 yeast mutants that had previously presented strong sensitivity to this widely used anticancer agent. Thirty-four mutants were responsive to carboplatin, and from these, 21 genes were selected for further studies because they have human homologues. Sixty percent of these yeast genes possessed human homologues which encoded proteins that interact with cullin scaffolds of ubiquitin ligases, or whose mRNA are under the regulation of Human antigen R (HuR) protein. Both HuR and cullin proteins are regulated through NEDDylation post-translational modification, and so our results indicate that inhibition of this process should sensitise resistant tumour cells to carboplatin. We showed that treatment of a tumour cell line with MLN4924, a NEDDylation inhibitor, overcame the resistance to carboplatin. Our data suggest that inhibition of NEDDylation may be a useful strategy to resensitise tumour cells in patients that have acquired carboplatin resistance. PMID:26692264

    5. Analysis of mRNA decay and rRNA processing in Escherichia coli multiple mutants carrying a deletion in RNase III.

      PubMed Central

      Babitzke, P; Granger, L; Olszewski, J; Kushner, S R

      1993-01-01

      RNase III is an endonuclease involved in processing both rRNA and certain mRNAs. To help determine whether RNase III (rnc) is required for general mRNA turnover in Escherichia coli, we have created a deletion-insertion mutation (delta rnc-38) in the structural gene. In addition, a series of multiple mutant strains containing deficiencies in RNase II (rnb-500), polynucleotide phosphorylase (pnp-7 or pnp-200), RNase E (rne-1 or rne-3071), and RNase III (delta rnc-38) were constructed. The delta rnc-38 single mutant was viable and led to the accumulation of 30S rRNA precursors, as has been previously observed with the rnc-105 allele (P. Gegenheimer, N. Watson, and D. Apirion, J. Biol. Chem. 252:3064-3073, 1977). In the multiple mutant strains, the presence of the delta rnc-38 allele resulted in the more rapid decay of pulse-labeled RNA but did not suppress conditional lethality, suggesting that the lethality associated with altered mRNA turnover may be due to the stabilization of specific mRNAs. In addition, these results indicate that RNase III is probably not required for general mRNA decay. Of particular interest was the observation that the delta rnc-38 rne-1 double mutant did not accumulate 30S rRNA precursors at 30 degrees C, while the delta rnc-38 rne-3071 double mutant did. Possible explanations of these results are discussed. Images PMID:8416898

    6. Electrochemical mineralization of the azo dye Acid Red 29 (Chromotrope 2R) by photoelectro-Fenton process.

      PubMed

      Almeida, Lucio Cesar; Garcia-Segura, Sergi; Arias, Conchita; Bocchi, Nerilso; Brillas, Enric

      2012-10-01

      The degradation of 100 mL of 244 mg L(-1) of the azo dye Acid Red 29 (AR29) has been studied by photoelectro-Fenton (PEF) using an undivided cell containing a boron-doped diamond (BDD) anode and an air-diffusion cathode under UVA irradiation. The effect of current density, concentration of catalytic Fe(2+) and pH on the process was examined. Quick decolorization and almost total mineralization were achieved due to the synergistic action of UVA light and oxidant hydroxyl radicals formed in the bulk from Fenton's reaction between electrogenerated H(2)O(2) at the cathode and added Fe(2+), as well as in the BDD surface from water oxidation. Optimum PEF conditions were found for 0.5-1.0 mM Fe(2+) and pH 3.0. Comparable electro-Fenton (EF) degradations in the dark yielded much poorer mineralization. The decay kinetics of AR29 followed a pseudo-first-order reaction with similar rate for EF and PEF. The azo dye disappeared much more rapidly than solution color, suggesting the formation of colored conjugated products with λ(max) similar to that of AR29. Ion-exclusion HPLC allowed the detection and quantification of tetrahydroxy-p-benzoquinone, oxalic, oxalacetic, tartronic, tartaric, oxamic, malonic and fumaric acids as intermediates in the PEF process. Oxalic acid, accumulated in large extent, was quickly destroyed by the efficient photolysis of Fe(III)-oxalate complexes with UVA light, whereas tartronic and oxamic acids were the most persistent byproducts because of the larger stability of their Fe(III) complexes. The mineralization of the initial N of the azo dye yielded NH(4)(+) ion and NO(3)(-) ion in smaller proportion. PMID:22854020

    7. The role of binaries in the enrichment of the early Galactic halo. I. r-process-enhanced metal-poor stars

      NASA Astrophysics Data System (ADS)

      Hansen, T. T.; Andersen, J.; Nordström, B.; Beers, T. C.; Yoon, J.; Buchhave, L. A.

      2015-11-01

      Context. The detailed chemical composition of most metal-poor halo stars has been found to be highly uniform, but a minority of stars exhibit dramatic enhancements in their abundances of heavy neutron-capture elements and/or of carbon. The key question for Galactic chemical evolution models is whether these peculiarities reflect the composition of the natal clouds, or if they are due to later (post-birth) mass transfer of chemically processed material from a binary companion. If the former case applies, the observed excess of certain elements was implanted within selected clouds in the early ISM from a production site at interstellar distances. Aims: Our aim is to determine the frequency and orbital properties of binaries among these chemically peculiar stars. This information provides the basis for deciding whether local mass transfer from a binary companion is necessary and sufficient to explain their unusual compositions. This paper discusses our study of a sample of 17 moderately (r-I) and highly (r-II) r-process-element enhanced VMP and EMP stars. Methods: High-resolution, low signal-to-noise spectra of the stars were obtained at roughly monthly intervals over eight years with the FIES spectrograph at the Nordic Optical Telescope. From these spectra, radial velocities with an accuracy of ~100 m s-1 were determined by cross-correlation against an optimized template. Results: Fourteen of the programme stars exhibit no significant radial-velocity variation over this temporal window, while three are binaries with orbits of typical eccentricity for their periods, resulting in a normal binary frequency of ~18 ± 6% for the sample. Conclusions: Our results confirm our preliminary conclusion from 2011, based on partial data, that the chemical peculiarity of the r-I and r-II stars is not caused by any putative binary companions. Instead, it was imprinted on the natal molecular clouds of these stars by an external, distant source. Models of the ISM in early galaxies should account for such mechanisms. Appendices are available in electronic form at http://www.aanda.org

    8. Assessing the reliability and validity of the Revised Two Factor Study Process Questionnaire (R-SPQ2F) in Ghanaian medical students

      PubMed Central

      2014-01-01

      Purpose: We investigated the validity and reliability of the Revised Two Factor Study Process Questionnaire (R-SPQ2F) in preclinical students in Ghana. Methods: The R-SPQ2F was administered to 189 preclinical students of the University for Development Studies, School of Medicine and Health Sciences. Both descriptive and inferential statistics with Cronbach’s alpha test and factor analysis were done. Results: The mean age of the students was 22.69± 0.18years, 60.8% (n=115) were males and 42.3% (n=80) were in their second year of medical training. The students had higher mean deep approach scores (31.23±7.19) than that of surface approach scores (22.62±6.48). Findings of the R-SPQ2F gave credence to a solution of two-factors indicating deep and surface approaches accounting for 49.80% and 33.57%, respectively, of the variance. The scales of deep approach (Cronbach’s alpha, 0.80) and surface approach (Cronbach’s alpha, 0.76) and their subscales demonstrated an internal consistency that was good. The factorial validity was comparable to other studies. Conclusion: Our study confirms the construct validity and internal consistency of the R-SPQ2F for measuring approaches to learning in Ghanaian preclinical students. Deep approach was the most dominant learning approach among the students. The questionnaire can be used to measure students’ approaches to learning in Ghana and in other African countries. PMID:25112447

    9. Quaternary bedrock erosion and landscape evolution in the Sør Rondane Mountains, East Antarctica: Reevaluating rates and processes

      NASA Astrophysics Data System (ADS)

      Matsuoka, Norikazu; Thomachot, Céline E.; Oguchi, Chiaki T.; Hatta, Tamao; Abe, Masahiro; Matsuzaki, Hiroyuki

      2006-11-01

      Rates and processes of rock weathering, soil formation, and mountain erosion during the Quaternary were evaluated in an inland Antarctic cold desert. The fieldwork involved investigations of weathering features and soil profiles for different stages after deglaciation. Laboratory analyses addressed chemistry of rock coatings and soils, as well as 10Be and 26Al exposure ages of the bedrock. Less resistant gneiss bedrock exposed over 1 Ma shows stone pavements underlain by in situ produced silty soils thinner than 40 cm and rich in sulfates, which reflect the active layer thickness, the absence of cryoturbation, and the predominance of salt weathering. During the same exposure period, more resistant granite bedrock has undergone long-lasting cavernous weathering that produces rootless mushroom-like boulders with a strongly Fe-oxidized coating. The red coating protects the upper surface from weathering while very slow microcracking progresses by the growth of sulfates. Geomorphological evidence and cosmogenic exposure ages combine to provide contrasting average erosion rates. No erosion during the Quaternary is suggested by a striated roche moutonnée exposed more than 2 Ma ago. Differential erosion between granite and gneiss suggests a significant lowering rate of desert pavements in excess of 10 m Ma - 1 . The landscape has been (on the whole) stable, but the erosion rate varies spatially according to microclimate, geology, and surface composition.

    10. Reliability and validity of an Arabic version of the revised two-factor study process questionnaire R-SPQ-2F

      PubMed Central

      Munshi, Fadi M.; Al-Rukban, Mohammad O.; Al-Hoqail, Ibrahim

      2012-01-01

      Objective: How students accomplish their learning and what they learn is an indicator of the quality of student learning. An insight into the learning approaches of a student could assist educators of the health profession in their planning for the first year of study. The aim of this study was to develop a reliable and valid Arabic version of the revised two-factor study process questionnaire. Materials and Methods: The translation of the revised two-Factor Study Process Questionnaire (R-SPQ-2F) into Arabic was done by an established forward–backward translation procedure. The Arabic version was then distributed to high school graduates applying for a place in the medical program at King Fahad Medical City. A total of 83 students voluntarily completed the questionnaire. The internal consistency and construct validity of the Arabic version of the R-SPQ-2F were computed. Results: The exploratory factor analysis revealed two components. The two factors were similar to the main scales described in the original English questionnaire. The main scales were the deep and surface approach. The items for the subscales (deep motive, deep strategy and surface motive, surface strategy) had a high internal consistency of more than 0.80. Conclusions: The results of this study should provide a valid and reliable instrument for the evaluation of the study approaches of Arabic speaking students. PMID:22518356

    11. An r-process macronova/kilonova in GRB 060614: evidence for the merger of a neutron star-black hole binary

      NASA Astrophysics Data System (ADS)

      Jin, Zhi-Ping; Fan, Yi-Zhong; Wei, Da-Ming

      2016-02-01

      After the jet break at t ~ 1.4 days, the optical afterglow emission of the long-short burst GRB 060614 can be divided into two components. One is the power-law decaying forward shock afterglow emission. The other is an excess of flux in several multi-band photometric observations, which emerges at ~4 days after the burst, significantly earlier than that observed for a supernova associated with a long-duration GRB. At t > 13.6 days, the F814W-band flux drops faster than t-3.2. Moreover, the spectrum of the excess component is very soft and the luminosity is extremely low. These observed signals are incompatible with those from weak supernovae, but the ejection of ~ 0.1 M⊙ of r-process material from a black hole-neutron star merger, as recently found in some numerical simulations, can produce it. If this interpretation is correct, it represents the first time that a multi-epoch/band lightcurve of a Li-Paczynski macronova (also known as kilonova) has been obtained and black hole-neutron star mergers are sites of significant production of r-process elements.

    12. Experimental study of the {sup 11,12}B(n,{gamma}) reactions and their influence on r-process nucleosynthesis of light elements

      SciTech Connect

      Lee, H. Y.; Greene, J. P.; Jiang, C. L.; Pardo, R. C.; Rehm, K. E.; Schiffer, J. P.; Wuosmaa, A. H.; Goodman, N. J.; Lighthall, J. C.; Marley, S. T.; Otsuki, K.; Patel, N.; Beard, M.; Notani, M.; Tang, X. D.

      2010-01-15

      We have studied the neutron-transfer reactions {sup 11,12}B(d,p){sup 12,13}B in inverse kinematics to obtain information about the neutron-capture reactions {sup 11,12}B(n,{gamma}). These capture reactions are suggested to play a role in seeding r-process nucleosynthesis through the production of light, neutron-rich nuclei. The neutron spectroscopic factors of the states in {sup 12,13}B were deduced and the branching ratio of the neutron-unbound state at E{sub X}=3.389 MeV in {sup 12}B was obtained to provide the ratio of partial widths, {Gamma}{sub n}/{Gamma}{sub {gamma}}. The reaction rates for {sup 11,12}B(n,{gamma}) are estimated for direct captures and resonant captures and compared with previous compilations. The astrophysical implications, especially for neutrino-driven wind models in core-collapse supernovae, are discussed in the r-process network framework using our updated reaction rates.

    13. Experimental study of the {sup 11,12}B(n,gamma) reactions and their influence on r-process nucleosynthesis of light elements.

      SciTech Connect

      Lee, H. Y.; Greene, J. P.; Jiang, C. L.; Pardo, R. C.; Rehm , K. E.; Schiffer, J. P.; Wuosmaa, A. H.; Goodman, N. J.; Lighthall, J. C.; Marley, S. T.; Otsuki, K.; Patel, N.; Beard, M.; Notani, M.; Tang, X. D.; Physics; Western Michigan Univ.; GSI; Colorado School of Mines; Univ. of Notre Dame

      2010-01-01

      We have studied the neutron-transfer reactions {sup 11,12}B(d,p){sup 12,13}B in inverse kinematics to obtain information about the neutron-capture reactions {sup 11,12}B(n,{gamma}). These capture reactions are suggested to play a role in seeding r-process nucleosynthesis through the production of light, neutron-rich nuclei. The neutron spectroscopic factors of the states in {sup 12,13}B were deduced and the branching ratio of the neutron-unbound state at E{sub X} = 3.389 MeV in {sup 12}B was obtained to provide the ratio of partial widths, {Lambda}{sub n}/{Lambda}{sub {gamma}}. The reaction rates for {sup 11,12}B(n,{gamma}) are estimated for direct captures and resonant captures and compared with previous compilations. The astrophysical implications, especially for neutrino-driven wind models in core-collapse supernovae, are discussed in the r-process network framework using our updated reaction rates.

    14. High-resolution microscopy of active ribosomal genes and key members of the rRNA processing machinery inside nucleolus-like bodies of fully-grown mouse oocytes.

      PubMed

      Shishova, Kseniya V; Khodarovich, Yuriy M; Lavrentyeva, Elena A; Zatsepina, Olga V

      2015-10-01

      Nucleolus-like bodies (NLBs) of fully-grown (germinal vesicle, GV) mammalian oocytes are traditionally considered as morphologically distinct entities, which, unlike normal nucleoli, contain transcribed ribosomal genes (rDNA) solely at their surface. In the current study, we for the first time showed that active ribosomal genes are present not only on the surface but also inside NLBs of the NSN-type oocytes. The "internal" rRNA synthesis was evidenced by cytoplasmic microinjections of BrUTP as precursor and by fluorescence in situ hybridization with a probe to the short-lived 5'ETS segment of the 47S pre-rRNA. We further showed that in the NLB mass of NSN-oocytes, distribution of active rDNA, RNA polymerase I (UBF) and rRNA processing (fibrillarin) protein factors, U3 snoRNA, pre-rRNAs and 18S/28S rRNAs is remarkably similar to that in somatic nucleoli capable to make pre-ribosomes. Overall, these observations support the occurrence of rDNA transcription, rRNA processing and pre-ribosome assembly in the NSN-type NLBs and so that their functional similarity to normal nucleoli. Unlike the NSN-type NLBs, the NLBs of more mature SN-oocytes do not contain transcribed rRNA genes, U3 snoRNA, pre-rRNAs, 18S and 28S rRNAs. These results favor the idea that in a process of transformation of NSN-oocytes to SN-oocytes, NLBs cease to produce pre-ribosomes and, moreover, lose their rRNAs. We also concluded that a denaturing fixative 70% ethanol used in the study to fix oocytes could be more appropriate for light microscopy analysis of nucleolar RNAs and proteins in mammalian fully-grown oocytes than a commonly used cross-linking aldehyde fixative, formalin. PMID:26226217

    15. The Dorsolateral Prefrontal Cortex Plays a Role in Self-Initiated Elaborative Cognitive Processing during Episodic Memory Encoding: rTMS Evidence

      PubMed Central

      Hawco, Colin; Berlim, Marcelo T.; Lepage, Martin

      2013-01-01

      During episodic memory encoding, elaborative cognitive processing can improve later recall or recognition. While multiple studies examined the neural correlates of encoding strategies, few studies have explicitly focused on the self-initiation of elaborative encoding. Repetitive transcranial magnetic stimulation (rTMS), a method which can transiently disrupt neural activity, was administered during an associative encoding task. rTMS was either applied to the left dorsolateral prefrontal cortex (DLPFC) or to the vertex (a control region not involved in memory encoding) during presentation of pairs of words. Pairs could be semantically related or not related. Two encoding instructions were given, either cueing participants to analyze semantic relationships (cued condition), or to memorize the pair without any specific strategy cues (the self-initiated condition). Participants filled out a questionnaire regarding their use of memory strategies and performed a cued-recall task. We hypothesized that if the DLPFC plays a role in the self-initiation of elaborative encoding we would observe a reduction in memory performance in the self-initiated condition, particularly for related. We found a significant correlation between the effects of rTMS and strategy use, only in the self-initiated condition with related pairs. High strategy users showed reduced performance following DLPFC stimulation, while low strategy users tended to show increased recall following DLPFC stimulation during encoding. These results suggest the left DLPFC may be involved in the self-initiation of memory strategy use, and individuals may utilize different neural networks depending on their use of encoding strategies. PMID:24040072

    16. Genome-wide analysis of small nucleolar RNAs of Leishmania major reveals a rich repertoire of RNAs involved in modification and processing of rRNA.

      PubMed

      Eliaz, Dror; Doniger, Tirza; Tkacz, Itai Dov; Biswas, Viplov Kumar; Gupta, Sachin Kumar; Kolev, Nikolay G; Unger, Ron; Ullu, Elisabetta; Tschudi, Christian; Michaeli, Shulamit

      2015-01-01

      Trypanosomatids are protozoan parasites and the causative agent of infamous infectious diseases. These organisms regulate their gene expression mainly at the post-transcriptional level and possess characteristic RNA processing mechanisms. In this study, we analyzed the complete repertoire of Leishmania major small nucleolar (snoRNA) RNAs by performing RNA-seq analysis on RNAs that were affinity-purified using the C/D snoRNA core protein, SNU13, and the H/ACA core protein, NHP2. This study revealed a large collection of C/D and H/ACA snoRNAs, organized in gene clusters generally containing both snoRNA types. Abundant snoRNAs were identified and predicted to guide trypanosome-specific rRNA cleavages. The repertoire of snoRNAs was compared to that of the closely related Trypanosoma brucei, and 80% of both C/D and H/ACA molecules were found to have functional homologues. The comparative analyses elucidated how snoRNAs evolved to generate molecules with analogous functions in both species. Interestingly, H/ACA RNAs have great flexibility in their ability to guide modifications, and several of the RNA species can guide more than one modification, compensating for the presence of single hairpin H/ACA snoRNA in these organisms. Placing the predicted modifications on the rRNA secondary structure revealed hypermodification regions mostly in domains which are modified in other eukaryotes, in addition to trypanosome-specific modifications. PMID:25970223

    17. SWATH2stats: An R/Bioconductor Package to Process and Convert Quantitative SWATH-MS Proteomics Data for Downstream Analysis Tools

      PubMed Central

      Blattmann, Peter; Heusel, Moritz; Aebersold, Ruedi

      2016-01-01

      SWATH-MS is an acquisition and analysis technique of targeted proteomics that enables measuring several thousand proteins with high reproducibility and accuracy across many samples. OpenSWATH is popular open-source software for peptide identification and quantification from SWATH-MS data. For downstream statistical and quantitative analysis there exist different tools such as MSstats, mapDIA and aLFQ. However, the transfer of data from OpenSWATH to the downstream statistical tools is currently technically challenging. Here we introduce the R/Bioconductor package SWATH2stats, which allows convenient processing of the data into a format directly readable by the downstream analysis tools. In addition, SWATH2stats allows annotation, analyzing the variation and the reproducibility of the measurements, FDR estimation, and advanced filtering before submitting the processed data to downstream tools. These functionalities are important to quickly analyze the quality of the SWATH-MS data. Hence, SWATH2stats is a new open-source tool that summarizes several practical functionalities for analyzing, processing, and converting SWATH-MS data and thus facilitates the efficient analysis of large-scale SWATH/DIA datasets. PMID:27054327

    18. SWATH2stats: An R/Bioconductor Package to Process and Convert Quantitative SWATH-MS Proteomics Data for Downstream Analysis Tools.

      PubMed

      Blattmann, Peter; Heusel, Moritz; Aebersold, Ruedi

      2016-01-01

      SWATH-MS is an acquisition and analysis technique of targeted proteomics that enables measuring several thousand proteins with high reproducibility and accuracy across many samples. OpenSWATH is popular open-source software for peptide identification and quantification from SWATH-MS data. For downstream statistical and quantitative analysis there exist different tools such as MSstats, mapDIA and aLFQ. However, the transfer of data from OpenSWATH to the downstream statistical tools is currently technically challenging. Here we introduce the R/Bioconductor package SWATH2stats, which allows convenient processing of the data into a format directly readable by the downstream analysis tools. In addition, SWATH2stats allows annotation, analyzing the variation and the reproducibility of the measurements, FDR estimation, and advanced filtering before submitting the processed data to downstream tools. These functionalities are important to quickly analyze the quality of the SWATH-MS data. Hence, SWATH2stats is a new open-source tool that summarizes several practical functionalities for analyzing, processing, and converting SWATH-MS data and thus facilitates the efficient analysis of large-scale SWATH/DIA datasets. PMID:27054327

    19. Development and evaluation of wastewater-treatment processes at the H-Coal site in Catlettsburg, Kentucky. Volume I. Design summary and R and D task identification

      SciTech Connect

      Oswald, G.E.; Walker, J.F.; Brown, C.H.; Klein, J.A.; Genung, R.K.

      1982-04-01

      The design of a mobile process development unit (PDU) for coal conversion wastewater treatment and an overview of the associated R and D program for its use are described. The PDU consists of three modular units, which can be arranged in various sequences: carbon adsorption, ozonation, and reverse osmosis. Each of the units has a nominal flow capacity of approx. 60 mL of wastewater feed per second (1 gpm). The feed to the PDU will be taken as a sidestream from the existing wastewater treatment system at the H-Coal site. It will have been processed through oil-water separation and distillation stripping, and can be taken both before and after bio-oxidation by an activated sludge process. The ozonation system experimental parameters are ozone contact time, ozone treatment rate, column pressure, and pH. The system will be analyzed as a continuous stirred tank reactor. The calculated results will include ozone reaction, treatment, and absorption rates, contaminant depletion and reaction rates, ozone absorption and contaminant removal efficiencies, and ozone volumetric mass-transfer coefficients. The carbon adsorption system will be operated to obtain bed-depth-service-time (BDST) data for various carbons and operating conditions. The BDST method will yield the rate of carbon exhaustion as well as the minimum depth of carbon required to remove contaminants. Reverse osmosis will be studied to measure dissolved solids rejection efficiency, permeate recovery, and fouling characteristics of various commercially available membranes.

    20. EVALUATING REGIONAL PREDICTIVE CAPACITY OF A PROCESS-BASED MERCURY EXPOSURE MODEL, REGIONAL-MERCURY CYCLING MODEL (R-MCM), APPLIED TO 91 VERMONT AND NEW HAMPSHIRE LAKES AND PONDS, USA

      EPA Science Inventory

      Regulatory agencies must develop fish consumption advisories for many lakes and rivers with limited resources. Process-based mathematical models are potentially valuable tools for developing regional fish advisories. The Regional Mercury Cycling model (R-MCM) was specifically d...

    1. Diverse nucleosynthetic components in barium isotopes of carbonaceous chondrites: Incomplete mixing of s- and r-process isotopes and extinct 135Cs in the early solar system

      NASA Astrophysics Data System (ADS)

      Hidaka, Hiroshi; Yoneda, Shigekazu

      2011-07-01

      Barium isotopic compositions of chemical leachates from six carbonaceous chondrites, Orgueil (CI), Mighei (CM2), Murray (CM2), Efremovka (CV3), Kainsaz (CO3), and Karoonda (CK4), were determined using thermal ionization mass spectrometry in order to assess the chemical evolution in the early solar system. The Ba isotopic data from most of the leachates show variable 135Ba excesses correlated with 137Ba excesses, suggesting the presence and heterogeneity of additional nucleosynthetic components for s- and r-processes in the solar system. The isotopic deviations observed in this study were generally small (-1 < ɛ < +1) except in the case of the acid residues of CI and CM meteorites. Large deviations of 135Ba (ɛ = -13.5 to -5.0) and 137Ba (ɛ = -6.2˜-1.2) observed in the acid residues from one CI and two CM meteorites show significant evidence for the enrichment of s-process isotopes derived from presolar grains. Two models were proposed to estimate the 135Cs isotopic abundances by subtraction of the s- and r-isotopic components from the total Ba isotopic abundances in the three CM meteorites, Mighei, Murchison (measured in a previous study), and Murray. The data points show individual linear trends between 135Cs/ 136Ba ratios and 135Ba isotopic deviations for the three samples. Considering the different trends observed in the three CM meteorites, the Ba isotopic composition of the CM meteorite parent body was heterogeneous at its formation. Chronological information is unclear in the data for Murchison and Murray because of large analytical uncertainties imposed by error propagation. Only the Mighei meteorite data indicate the possible existence of presently extinct 135Cs ( 135Cs/ 133Cs = (2.7 ± 1.6) × 10 -4) in the early solar system. Another explanation of the data for the three CM meteorite is mixing of at least three components with different Ba isotopic compositions, although this is model-dependent.

    2. PV Manufacturing R&D Project Status and Accomplishments under 'In-Line Diagnostics and Intelligent Processing' and 'Yield, Durability and Reliability': Preprint

      SciTech Connect

      Friedman, D. J.; Mitchell, R. L.; Keyes, B. M.; Bower, W. I.; King, R.; Mazer, J.

      2006-05-01

      The PV Manufacturing R&D (PVMR&D) Project conducts cost-shared research and development programs with U.S. PV industry partners. There are currently two active industry partnership activities. ''In-line Diagnostics and Intelligent Processing'', launched in 2002, supports development of new in-line diagnostics and monitoring with real-time feedback for optimal process control and increased yield in the fabrication of PV modules, systems, and other system components. ''Yield, Durability and Reliability'', launched in late 2004, supports enhancement of PV module, system component, and complete system reliability in high-volume manufacturing. A second key undertaking of the PVMR&D Project is the collection and analysis of module production cost-capacity metrics for the U.S. PV industry. In the period from 1992 through 2005, the average module manufacturing cost in 2005 dollars fell 54% (5.7% annualized) to $2.74/Wp, and the capacity increased 18.6-fold (25% annualized) to 253 MW/yr. An experience curve analysis gives progress ratios of 87% and 81%, respectively, for U.S. silicon and thin-film module production.

    3. Oxygenated fraction and mass of organic aerosol from direct emission and atmospheric processing measured on the R/V Ronald Brown during TEXAQS/GoMACCS 2006

      NASA Astrophysics Data System (ADS)

      Russell, L. M.; Takahama, S.; Liu, S.; Hawkins, L. N.; Covert, D. S.; Quinn, P. K.; Bates, T. S.

      2009-04-01

      Submicron particles collected on Teflon filters aboard the R/V Ronald Brown during the Texas Air Quality Study and Gulf of Mexico Atmospheric Composition and Climate Study (TexAQS/GoMACCS) 2006 in and around the port of Houston, Texas, were measured by Fourier transform infrared (FTIR) and X-ray fluorescence for organic functional groups and elemental composition. Organic mass (OM) concentrations (1-25 μg m-3) for ambient particle samples measured by FTIR showed good agreement with measurements made with an aerosol mass spectrometer. The fractions of organic mass identified as alkane and carboxylic acid groups were 47% and 32%, respectively. Three different types of air masses were identified on the basis of the air mass origin and the radon concentration, with significantly higher carboxylic acid group mass fractions in air masses from the north (35%) than the south (29%) or Gulf of Mexico (26%). Positive matrix factorization analysis attributed carboxylic acid fractions of 30-35% to factors with mild or strong correlations (r > 0.5) to elemental signatures of oil combustion and 9-24% to wood smoke, indicating that part of the carboxylic acid fraction of OM was formed by the same sources that controlled the metal emissions, namely the oil and wood combustion activities. The implication is that a substantial part of the measured carboxylic acid contribution was formed independently of traditionally "secondary" processes, which would be affected by atmospheric (both photochemical and meteorological) conditions and other emission sources. The carboxylic acid group fractions in the Gulf of Mexico and south air masses (GAM and SAM, respectively) were largely oil combustion emissions from ships as well as background marine sources, with only limited recent land influences (based on radon concentrations). Alcohol groups accounted for 14% of OM (mostly associated with oil combustion emissions and background sources), and amine groups accounted for 4% of OM in all air masses. Organosulfate groups were found in GAM and SAM, accounting for 1% and 3% of OM, respectively. Two thirds of the OM and oxygen-to-carbon (O/C) measured could be attributed to oil and wood combustion sources on the basis of mild or strong correlations to coemitted, nonvolatile trace metals, with the remaining one third being associated with atmospherically processed organic aerosol. The cloud condensation nuclei (CCN) fraction (normalized by total condensation nuclei) had weak correlations to the alcohol and amine group fractions and mild correlation with O/C, also varying inversely with alkane group fraction. The chemical components that influenced f(RH) were sulfate, organic, and nitrate fraction, but this contrast is consistent with the size-distribution dependence of CCN counters and nephelometers.

    4. A precision measurement of the Z{sup 0} lineshape parameters for the process Z{sup 0} {r_arrow} {tau}{sup +}{tau}{sup {minus}}

      SciTech Connect

      Lahmann, R.

      1996-12-31

      In this dissertation, a measurement of the partial decay width of the process Z{sup 0} {r_arrow} {tau}{sup +}{tau}{sup {minus}} using data collected during 1993 and 1994 at the OPAL detector at CERN is described. The cross sections of this process at three center-of-mass energies near the Z{sup 0} resonance were determined, and from a fit to those cross sections, the mass of the Z{sup 0}, its total decay width and its partial decay width into {tau}{sup +}{tau}{sup {minus}} final states were determined as M{sub Z} = 91.183 {+-} 0.020 GeV, {Lambda}{sub tot} = 2.514 {+-} 0.018 GeV and {Lambda}{sub {tau}{tau}} = 84.54 {+-} 0.59 MeV. Using published results for M{sub Z}, and {Lambda}{sub tot} with higher accuracy, a value for the partial decay width of {Lambda}{sub {tau}{tau}} = 84.02 {+-} 0.20 MeV was obtained. Further using published results for the decay width of the Z{sup 0} into quark pair final states, the invisible decay width of the Z{sup 0} was determined as {Lambda}{sub inv} = 496.9 {+-} 4.1 MeV, and the number of neutrino generations was determined as N{sub {nu}} = 2.974 {+-} 0.025(exp) {+-} 0.007 (m{sub top}, M{sub Higgs}). All results were found to be in good agreement with the Standard Model predictions and were consistent with the assumption of lepton universality within the Standard Model framework.

    5. Ptc6 Is Required for Proper Rapamycin-Induced Down-Regulation of the Genes Coding for Ribosomal and rRNA Processing Proteins in S. cerevisiae

      PubMed Central

      González, Asier; Casado, Carlos; Ariño, Joaquín; Casamayor, Antonio

      2013-01-01

      Ptc6 is one of the seven components (Ptc1-Ptc7) of the protein phosphatase 2C family in the yeast Saccharomyces cerevisiae. In contrast to other type 2C phosphatases, the cellular role of this isoform is poorly understood. We present here a comprehensive characterization of this gene product. Cells lacking Ptc6 are sensitive to zinc ions, and somewhat tolerant to cell-wall damaging agents and to Li+. Ptc6 mutants are sensitive to rapamycin, albeit to lesser extent than ptc1 cells. This phenotype is not rescued by overexpression of PTC1 and mutation of ptc6 does not reproduce the characteristic genetic interactions of the ptc1 mutation with components of the TOR pathway, thus suggesting different cellular roles for both isoforms. We show here that the rapamycin-sensitive phenotype of ptc6 cells is unrelated to the reported role of Pt6 in controlling pyruvate dehydrogenase activity. Lack of Ptc6 results in substantial attenuation of the transcriptional response to rapamycin, particularly in the subset of repressed genes encoding ribosomal proteins or involved in rRNA processing. In contrast, repressed genes involved in translation are Ptc6-independent. These effects cannot be attributed to the regulation of the Sch9 kinase, but they could involve modulation of the binding of the Ifh1 co-activator to specific gene promoters. PMID:23704987

    6. Interpretation of Fracture Toughness and R-Curve Behavior by Direct Observation of Microfracture Process in Ti-Based Dendrite-Containing Amorphous Alloys

      NASA Astrophysics Data System (ADS)

      Jeon, Changwoo; Kim, Choongnyun Paul; Kim, Hyoung Seop; Lee, Sunghak

      2015-04-01

      Fracture properties of Ti-based amorphous alloys containing ductile β dendrites were explained by directly observing microfracture processes. Three Ti-based amorphous alloys were fabricated by adding Ti, Zr, V, Ni, Al, and Be into a Ti-6Al-4V alloy by a vacuum arc melting method. The effective sizes of dendrites varied from 63 to 104 μm, while their volume fractions were almost constant within the range from 74 to 76 pct. The observation of the microfracture of the alloy containing coarse dendrites revealed that a microcrack initiated at the amorphous matrix of the notch tip and propagated along the amorphous matrix. In the alloy containing fine dendrites, the crack propagation was frequently blocked by dendrites, and many deformation bands were formed near or in front of the propagating crack, thereby resulting in a zig-zag fracture path. Crack initiation toughness was almost the same at 35 to 36 MPa√m within error ranges in the three alloys because it was heavily affected by the stress applied to the specimen at the time of crack initiation at the crack tip as well as strength levels of the alloys. According to the R-curve behavior, however, the best overall fracture properties in the alloy containing fine dendrites were explained by mechanisms of blocking of the crack growth and crack blunting and deformation band formation at dendrites.

    7. WBSCR22/Merm1 is required for late nuclear pre-ribosomal RNA processing and mediates N7-methylation of G1639 in human 18S rRNA

      PubMed Central

      Haag, Sara; Kretschmer, Jens

      2015-01-01

      Ribosomal (r)RNAs are extensively modified during ribosome synthesis and their modification is required for the fidelity and efficiency of translation. Besides numerous small nucleolar RNA-guided 2′-O methylations and pseudouridinylations, a number of individual RNA methyltransferases are involved in rRNA modification. WBSCR22/Merm1, which is affected in Williams–Beuren syndrome and has been implicated in tumorigenesis and metastasis formation, was recently shown to be involved in ribosome synthesis, but its molecular functions have remained elusive. Here we show that depletion of WBSCR22 leads to nuclear accumulation of 3′-extended 18SE pre-rRNA intermediates resulting in impaired 18S rRNA maturation. We map the 3′ ends of the 18SE pre-rRNA intermediates accumulating after depletion of WBSCR22 and in control cells using 3′-RACE and deep sequencing. Furthermore, we demonstrate that WBSCR22 is required for N7-methylation of G1639 in human 18S rRNA in vivo. Interestingly, the catalytic activity of WBSCR22 is not required for 18S pre-rRNA processing, suggesting that the key role of WBSCR22 in 40S subunit biogenesis is independent of its function as an RNA methyltransferase. PMID:25525153

    8. Re-interpreting R, R and R

      NASA Astrophysics Data System (ADS)

      Griffin, Elizabeth M.

      2015-08-01

      Why are we so much more aware of environmental issues today than was the case 100-150 years ago, when particle-laden smoke belched out of chimneys, modes of travel (both near and distant) were best sellers, and fluorescent lighting made it possible to work all night as well as all day? Are we now paying the price of the Industrial Revolution?Not altogether. Along with the side-effects of all such "improvements" have come two other parallel but crucial developments: (1) technology to control harmful emissions, and (2) increased populations, each demanding - and getting - freedom of choice, as did their recent ancestors.The Environmentalist's Motto, the Three Rs (Re-duce, Re-use, Re-cycle) is perfectly clear: the prime action in all cases is REDUCE. The individual, however, looks to "Them" to make by-laws, or install efficient road lighting and controls just in the the public domain. The individual rarely accepts that the R, R, R message applies also to him or her, and to his or her family. Where then is freedom of choice? We discuss the alternative Three Rs (Rights, Recreations, Responsibilities) of the Individual's Motto, and try to put them in working order. To do that, we discuss the impacts of night-time lighting on parties other than astronomers.

    9. (R)-Doxylaminium (R,R)-tartrate

      PubMed Central

      Dayananda, A.S.; Dutkiewicz, Grzegorz; Yathirajan, H. S.; Kubicki, Maciej

      2012-01-01

      In the title compound (systematic name: (R)-dimeth­yl{2-[1-phenyl-1-(pyridin-2-yl)eth­oxy]eth­yl}aza­nium (R,R)-3-carb­oxy-2,3-dihy­droxy­propano­ate), C17H23N2O+·C4H5O6 −, the doxylaminium cation is protonated at the N atom. The tartrate monoanions are linked by short, almost linear O—H⋯O hydrogen bonds into chains extended along [100]. These chains are inter­linked by anion–pyridine O—H⋯N hydrogen bonds into a two-dimensional grid structure. WeakC—H⋯O inter­actions also play a role in the crystal packing. An intra­molecular hy­droxy–carboxyl­ate O—H⋯O hydrogen bond influences the conformation of the anion: the hydrogen-bonded fragment is almost planar, the maximum deviation from the mean plane being 0.059 (14) Å. In the cation, the aromatic rings are almost perpendicular [dihedral angle = 84.94 (8)°] and the conformation of the O—C—C—N chain is gauche(−), the dihedral angle is −76.6 (2)°. The absolute configuration was assigned on the basis of known chirality of the parent compound. PMID:22589924

    10. Processes Affecting Tropospheric Ozone Inferred from Ozonesonde and Other Tracer Data from the R/V R H Brown Atlantic Cruise (37N-34S) in January-February 1999

      NASA Technical Reports Server (NTRS)

      Thompson, Anne M.; Doddridge, B. G.; Luke, W. T.; Johnson, J. E.; Witte, J. C.; Reynolds, R. M.; Johnson, B.; Oltmans, S. J.

      1999-01-01

      During the Aerosols-99 trans-Atlantic cruise from Norfolk, VA, to Cape Town, South Africa, 22 ozonesondes were launched from the NOAA R/V R H Brown between 17 Jan and 6 Feb 1999, with all sondes but one reaching 30 km. A composite of ozone profiles along the transect shows high free tropospheric ozone (up to 100 ppbv at 9 km) between 5N and 20S, a coherent feature straddling either side of the ITCZ. Latitudinal variations of tropospheric ozone are interpreted using correlative measurements of surface ozone, CO, water vapor, and aerosol optical thickness (column absorbance) measured from the ship. Elevated ozone in the lower troposphere results from photochemical reactions of precursors emitted by biomass burning north of the ITCZ. However, the greatest ozone mixing ratios are in the mid-troposphere south of the ITCZ, which gives evidence of interhemispheric transport. Column-integrated tropospheric ozone, 35 DU from 0-16 km, agrees with that derived from the TOMS satellite by the modified-residual method [Thompson and Hudson, 1999]. NCEP wind fields, ship-launched radiosondes and back trajectories are consistent with a picture of recirculating air parcels centered in the tropical Atlantic region which is identified with the maximum wave-one amplitude in total ozone seen in sondes and by satellite.

    11. Imp3 unfolds stem structures in pre-rRNA and U3 snoRNA to form a duplex essential for small subunit processing

      PubMed Central

      Shah, Binal N.; Liu, Xin; Correll, Carl C.

      2013-01-01

      Eukaryotic ribosome biogenesis requires rapid hybridization between the U3 snoRNA and the pre-rRNA to direct cleavages at the A0, A1, and A2 sites in pre-rRNA that liberate the small subunit precursor. The bases involved in hybridization of one of the three duplexes that U3 makes with pre-rRNA, designated the U3-18S duplex, are buried in conserved structures: box A/A? stemloop in U3 snoRNA and helix 1 (H1) in the 18S region of the pre-rRNA. These conserved structures must be unfolded to permit the necessary hybridization. Previously, we reported that Imp3 and Imp4 promote U3-18S hybridization in vitro, but the mechanism by which these proteins facilitate U3-18S duplex formation remained unclear. Here, we directly addressed this question by probing base accessibility with chemical modification and backbone accessibility with ribonuclease activity of U3 and pre-rRNA fragments that mimic the secondary structure observed in vivo. Our results demonstrate that U3-18S hybridization requires only Imp3. Binding to each RNA by Imp3 provides sufficient energy to unfold both the 18S H1 and the U3 box A/A? stem structures. The Imp3 unfolding activity also increases accessibility at the U3-dependent A0 and A1 sites, perhaps signaling cleavage at these sites to generate the 5? mature end of 18S. Imp4 destabilizes the U3-18S duplex to aid U3 release, thus differentiating the roles of these proteins. Protein-dependent unfolding of these structures may serve as a switch to block U3-pre-rRNA interactions until recruitment of Imp3, thereby preventing premature and inaccurate U3-dependent pre-rRNA cleavage and folding events in eukaryotic ribosome biogenesis. PMID:23980203

    12. SOT1, a pentatricopeptide repeat protein with a small MutS-related domain, is required for correct processing of plastid 23S-4.5S rRNA precursors in Arabidopsis thaliana.

      PubMed

      Wu, Wenjuan; Liu, Sheng; Ruwe, Hannes; Zhang, Delin; Melonek, Joanna; Zhu, Yajuan; Hu, Xupeng; Gusewski, Sandra; Yin, Ping; Small, Ian D; Howell, Katharine A; Huang, Jirong

      2016-03-01

      Ribosomal RNA processing is essential for plastid ribosome biogenesis, but is still poorly understood in higher plants. Here, we show that SUPPRESSOR OF THYLAKOID FORMATION1 (SOT1), a plastid-localized pentatricopeptide repeat (PPR) protein with a small MutS-related domain, is required for maturation of the 23S-4.5S rRNA dicistron. Loss of SOT1 function leads to slower chloroplast development, suppression of leaf variegation, and abnormal 23S and 4.5S processing. Predictions based on the PPR motif sequences identified the 5' end of the 23S-4.5S rRNA dicistronic precursor as a putative SOT1 binding site. This was confirmed by electrophoretic mobility shift assay, and by loss of the abundant small RNA 'footprint' associated with this site in sot1 mutants. We found that more than half of the 23S-4.5S rRNA dicistrons in sot1 mutants contain eroded and/or unprocessed 5' and 3' ends, and that the endonucleolytic cleavage product normally released from the 5' end of the precursor is absent in a sot1 null mutant. We postulate that SOT1 binding protects the 5' extremity of the 23S-4.5S rRNA dicistron from exonucleolytic attack, and favours formation of the RNA structure that allows endonucleolytic processing of its 5' and 3' ends. PMID:26800847

    13. rAAV-mediated overexpression of sox9, TGF-? and IGF-I in minipig bone marrow aspirates to enhance the chondrogenic processes for cartilage repair.

      PubMed

      Frisch, J; Rey-Rico, A; Venkatesan, J K; Schmitt, G; Madry, H; Cucchiarini, M

      2016-03-01

      Administration of therapeutic gene sequences coding for chondrogenic and chondroreparative factors in bone marrow aspirates using the clinically adapted recombinant adeno-associated virus (rAAV) vector may provide convenient, single-step approaches to improve cartilage repair. Here, we tested the ability of distinct rAAV constructs coding for the potent SOX9, transforming growth factor beta (TGF-?) and insulin-like growth factor I (IGF-I) candidate factors to modify marrow aspirates from minipigs to offer a preclinical large animal model system adapted for a translational evaluation of cartilage repair upon transplantation in sites of injury. Our results demonstrate that high, prolonged rAAV gene transfer efficiencies were achieved in the aspirates (up to 100% for at least 21 days) allowing to produce elevated amounts of the transcription factor SOX9 that led to increased levels of matrix synthesis and chondrogenic differentiation and of the growth factors TGF-? and IGF-I that both increased cell proliferation, matrix synthesis and chondrogenic differentiation (although to a lower level than SOX9) compared with control (lacZ) condition. Remarkably, application of the candidate SOX9 vector also led to reduced levels of hypertrophic differentiation in the aspirates, possibly by modulating the ?-catenin, Indian hedgehog and PTHrP pathways. The present findings show the benefits of modifying minipig marrow concentrates via rAAV gene transfer as a future means to develop practical strategies to promote cartilage repair in a large animal model. PMID:26583804

    14. Early stages of melody processing: stimulus-sequence and task-dependent neuronal activity in monkey auditory cortical fields A1 and R.

      PubMed

      Yin, Pingbo; Mishkin, Mortimer; Sutter, Mitchell; Fritz, Jonathan B

      2008-12-01

      To explore the effects of acoustic and behavioral context on neuronal responses in the core of auditory cortex (fields A1 and R), two monkeys were trained on a go/no-go discrimination task in which they learned to respond selectively to a four-note target (S+) melody and withhold response to a variety of other nontarget (S-) sounds. We analyzed evoked activity from 683 units in A1/R of the trained monkeys during task performance and from 125 units in A1/R of two naive monkeys. We characterized two broad classes of neural activity that were modulated by task performance. Class I consisted of tone-sequence-sensitive enhancement and suppression responses. Enhanced or suppressed responses to specific tonal components of the S+ melody were frequently observed in trained monkeys, but enhanced responses were rarely seen in naive monkeys. Both facilitatory and suppressive responses in the trained monkeys showed a temporal pattern different from that observed in naive monkeys. Class II consisted of nonacoustic activity, characterized by a task-related component that correlated with bar release, the behavioral response leading to reward. We observed a significantly higher percentage of both Class I and Class II neurons in field R than in A1. Class I responses may help encode a long-term representation of the behaviorally salient target melody. Class II activity may reflect a variety of nonacoustic influences, such as attention, reward expectancy, somatosensory inputs, and/or motor set and may help link auditory perception and behavioral response. Both types of neuronal activity are likely to contribute to the performance of the auditory task. PMID:18842950

    15. Investigation of a miRNA-Induced Gene Silencing Technique in Petunia Reveals Alterations in miR173 Precursor Processing and the Accumulation of Secondary siRNAs from Endogenous Genes

      PubMed Central

      Han, Yao; Zhang, Bin; Qin, Xiaoting; Li, Mingyang; Guo, Yulong

      2015-01-01

      MIGS (miRNA-induced gene silencing) is a straightforward and efficient gene silencing technique in Arabidopsis. It works by exploiting miR173 to trigger the production of phasiRNAs (phased small interfering RNAs). MIGS can be used in plant species other than Arabidopsis by co-expression of miR173 and target gene fragments fused to an upstream miR173 target site. However, the efficiency and technical mechanisms have not been thoroughly investigated in other plants. In this work, two vectors, pMIGS-chs and pMIGS-pds, were constructed and transformed into petunia plants. The transgenic plants showed CHS (chalcone synthase) and PDS (phytoene desaturase) gene-silencing phenotypes respectively, indicating that MIGS functions in petunia. MIGS-chs plants were used to investigate the mechanisms of this technique in petunia. Results of 5′- RACE showed that the miR173 target site was cleaved at the expected position and that endogenous CHS genes were cut at multiple positions. Small RNA deep sequencing analysis showed that the processing of Arabidopsis miR173 precursors in MIGS-chs transgenic petunia plants did not occur in exactly the same way as in Arabidopsis, suggesting differences in the machinery of miRNA processing between plant species. Small RNAs in-phase with the miR173 cleavage register were produced immediately downstream from the cleavage site and out-of-phase small RNAs were accumulated at relatively high levels from processing cycle 5 onwards. Secondary siRNAs were generated from multiple sites of endogenous CHS-A and CHS-J genes, indicating that miR173 cleavage induced siRNAs have the same ability to initiate siRNA transitivity as the siRNAs functioning in co-suppression and hpRNA silencing. On account of the simplicity of vector construction and the transitive amplification of signals from endogenous transcripts, MIGS is a good alternative gene silencing method for plants, especially for silencing a cluster of homologous genes with redundant functions. PMID:26658695

    16. A COMPOSITE HOLLOW FIBER MEMBRANE-BASED PERVAPORATION PROCESS FOR SEPARATION OF VOCS FROM AQUEOUS SURFACTANT SOLUTIONS. (R825511C027)

      EPA Science Inventory

      The separation and recovery of VOCs from surfactant-containing aqueous solutions by a composite hollow fiber membrane-based pervaporation process has been studied. The process employed hydrophobic microporous polypropylene hollow fibers having a thin plasma polymerized silicon...

    17. β-Decay Half-Lives of 110 Neutron-Rich Nuclei across the N=82 Shell Gap: Implications for the Mechanism and Universality of the Astrophysical r Process.

      PubMed

      Lorusso, G; Nishimura, S; Xu, Z Y; Jungclaus, A; Shimizu, Y; Simpson, G S; Söderström, P-A; Watanabe, H; Browne, F; Doornenbal, P; Gey, G; Jung, H S; Meyer, B; Sumikama, T; Taprogge, J; Vajta, Zs; Wu, J; Baba, H; Benzoni, G; Chae, K Y; Crespi, F C L; Fukuda, N; Gernhäuser, R; Inabe, N; Isobe, T; Kajino, T; Kameda, D; Kim, G D; Kim, Y-K; Kojouharov, I; Kondev, F G; Kubo, T; Kurz, N; Kwon, Y K; Lane, G J; Li, Z; Montaner-Pizá, A; Moschner, K; Naqvi, F; Niikura, M; Nishibata, H; Odahara, A; Orlandi, R; Patel, Z; Podolyák, Zs; Sakurai, H; Schaffner, H; Schury, P; Shibagaki, S; Steiger, K; Suzuki, H; Takeda, H; Wendt, A; Yagi, A; Yoshinaga, K

      2015-05-15

      The β-decay half-lives of 110 neutron-rich isotopes of the elements from _{37}Rb to _{50}Sn were measured at the Radioactive Isotope Beam Factory. The 40 new half-lives follow robust systematics and highlight the persistence of shell effects. The new data have direct implications for r-process calculations and reinforce the notion that the second (A≈130) and the rare-earth-element (A≈160) abundance peaks may result from the freeze-out of an (n,γ)⇄(γ,n) equilibrium. In such an equilibrium, the new half-lives are important factors determining the abundance of rare-earth elements, and allow for a more reliable discussion of the r process universality. It is anticipated that universality may not extend to the elements Sn, Sb, I, and Cs, making the detection of these elements in metal-poor stars of the utmost importance to determine the exact conditions of individual r-process events. PMID:26024165

    18. Effects of Low Frequency Repetitive Transcranial Magnetic Stimulation (rTMS) on Gamma Frequency Oscillations and Event-Related Potentials during Processing of Illusory Figures in Autism

      ERIC Educational Resources Information Center

      Sokhadze, Estate M.; El-Baz, Ayman; Baruth, Joshua; Mathai, Grace; Sears, Lonnie; Casanova, Manuel F.

      2009-01-01

      Previous studies by our group suggest that the neuropathology of autism is characterized by a disturbance of cortical modularity. In this model a decrease in the peripheral neuropil space of affected minicolumns provides for an inhibitory deficit and a readjustment in their signal to noise bias during information processing. In this study we…

    19. AN EXPERIMENTAL INVESTIGATION INTO THE EFFECT OF PROCESS CONDITIONS ON THE MASS CONCENTRATION OF CUTTING FLUID MIST IN TURNING. (R825370C057)

      EPA Science Inventory

      Cutting fluid mists that are generated during machining processes represent a significant waste stream as well as a health hazard to humans. Epidemiological studies have shown a link between worker exposure to cutting fluid mist and an increase in respiratory ailments and seve...

    20. The Earth's magnetosphere is 165 R(sub E) long: Self-consistent currents, convection, magnetospheric structure, and processes for northward interplanetary magnetic field

      NASA Technical Reports Server (NTRS)

      Fedder, J. A.; Lyon, J. G.

      1995-01-01

      The subject of this paper is a self-consistent, magnetohydrodynamic numerical realization for the Earth's magnetosphere which is in a quasi-steady dynamic equilibrium for a due northward interplanetary magnetic field (IMF). Although a few hours of steady northward IMF are required for this asymptotic state to be set up, it should still be of considerable theoretical interest because it constitutes a 'ground state' for the solar wind-magnetosphere interaction. Moreover, particular features of this ground state magnetosphere should be observable even under less extreme solar wind conditions. Certain characteristics of this magnetosphere, namely, NBZ Birkeland currents, four-cell ionospheric convection, a relatively weak cross-polar potential, and a prominent flow boundary layer, are widely expected. Other characteristics, such as no open tail lobes, no Earth-connected magnetic flux beyond 155 R(sub E) downstream, magnetic merging in a closed topology at the cusps, and a 'tadpole' shaped magnetospheric boundary, might not be expected. In this paper, we will present the evidence for this unusual but interesting magnetospheric equilibrium. We will also discuss our present understanding of this singular state.

    1. Bacterial Diversity Analysis during the Fermentation Processing of Traditional Chinese Yellow Rice Wine Revealed by 16S rDNA 454 Pyrosequencing.

      PubMed

      Fang, Ruo-si; Dong, Ya-chen; Chen, Feng; Chen, Qi-he

      2015-10-01

      Rice wine is a traditional Chinese fermented alcohol drink. Spontaneous fermentation with the use of the Chinese starter and wheat Qu lead to the growth of various microorganisms during the complete brewing process. It's of great importance to fully understand the composition of bacteria diversity in rice wine in order to improve the quality and solve safety problems. In this study, a more comprehensive bacterial description was shown with the use of bacteria diversity analysis, which enabled us to have a better understanding. Rarefaction, rank abundance, alpha Diversity, beta diversity and principal coordinates analysis simplified their complex bacteria components and provide us theoretical foundation for further investigation. It has been found bacteria diversity is more abundant at mid-term and later stage of brewing process. Bacteria community analysis reveals there is a potential safety hazard existing in the fermentation, since most of the sequence reads are assigned to Enterobacter (7900 at most) and Pantoea (7336 at most), followed by Staphylococcus (2796 at most) and Pseudomonas (1681 at most). Lactic acid bacteria are rare throughout the fermentation process which is not in accordance with other reports. This work may offer us an opportunity to investigate micro ecological fermentation system in food industry. PMID:26409170

    2. Systematic use of universal 16S rRNA gene polymerase chain reaction (PCR) and sequencing for processing pleural effusions improves conventional culture techniques.

      PubMed

      Insa, Rosario; Marn, Mercedes; Martn, Adoracin; Martn-Rabadn, Pablo; Alcal, Lus; Cercenado, Emilia; Calatayud, Laura; Liares, Josefina; Bouza, Emilio

      2012-03-01

      Conventional culture of pleural fluid samples frequently provides false-negative results. Universal polymerase chain reaction (PCR) of the 16S ribosomal ribonucleic acid (rRNA) gene (16S PCR) has proven useful in the diagnosis of various bacterial infections. We conducted a prospective study to assess the value of 16S PCR in the etiologic diagnosis of pleural effusion. All pleural fluid samples received for culture were also studied using 16S PCR. Positive samples were sequenced for identification. Clinical records and conventional culture results were analyzed to classify pleural fluid samples as infected or not infected. We studied 723 samples. We excluded 188 samples because they were obtained from a long-term chest tube, there was a diagnosis of mycobacterial infection, or there were insufficient data to classify the episode. Finally, 535 pleural fluid samples were analyzed. According to our criteria, 82 (15.3%) were infected and 453 (84.7%) were not infected. In the infected samples, 16S PCR was positive in 67 samples (81.7%) while conventional culture was positive in 45 (54.9%). There were 4 false positives with 16S PCR (0.9%) and 12 with culture (2.6%). The values for the etiologic diagnosis of bacterial pleural effusion of conventional culture compared with 16S PCR were as follows: sensitivity, 54.9%/81.7%; specificity, 97.4%/99.1%; positive predictive value, 76.3%/94.4%; negative predictive value, 92.6%/96.8%; and accuracy, 90.8%/96.5%.When compared with conventional culture, 16S PCR plus sequencing substantially improves the etiologic diagnosis of infectious pleural effusion. In our opinion, this technique should be added to the routine diagnostic armamentarium of clinical microbiology laboratories. PMID:22391472

    3. DExD-box RNA-helicases in Listeria monocytogenes are important for growth, ribosomal maturation, rRNA processing and virulence factor expression

      PubMed Central

      Bäreclev, Caroline; Vaitkevicius, Karolis; Netterling, Sakura; Johansson, Jörgen

      2014-01-01

      RNA-helicases are proteins required for the unwinding of occluding secondary RNA structures, especially at low temperatures. In this work, we have deleted all 4 DExD-box RNA helicases in various combinations in the Gram-positive pathogen Listeria monocytogenes. Our results show that 3 out of 4 RNA-helicases were important for growth at low temperatures, whereas the effect was less prominent at 37°C. Over-expression of one RNA-helicase, Lmo1450, was able to overcome the reduced growth of the quadruple mutant strain at temperatures above 26°C, but not at lower temperatures. The maturation of ribosomes was affected in different degrees in the various strains at 20°C, whereas the effect was marginal at 37°C. This was accompanied by an increased level of immature 23S rRNA precursors in some of the RNA-helicase mutants at low temperatures. Although the expression of the PrfA regulated virulence factors ActA and LLO decreased in the quadruple mutant strain, this strain showed a slightly increased infection ability. Interestingly, even though the level of the virulence factor LLO was decreased in the quadruple mutant strain as compared with the wild-type strain, the hly-transcript (encoding LLO) was increased. Hence, our results could suggest a role for the RNA-helicases during translation. In this work, we show that DExD-box RNA-helicases are involved in bacterial virulence gene-expression and infection of eukaryotic cells. PMID:25590644

    4. Cardiac R-wave detector

      NASA Technical Reports Server (NTRS)

      Gebben, V. D.

      1968-01-01

      Cardiac R wave detector obtains the systolic contraction signal of the human heart and uses it as a reference signal for the heart-assist pump cycle. It processes the electrocardiac signal /QRS wave complex/ of the natural heart in a sequence of operations which essentially elimates all components from the input signal except the R wave.

    5. Development of a Validated LC Method for Separation of Process-Related Impurities Including the R-Enantiomer of S-Pramipexole on Polysaccharide Chiral Stationary Phases.

      PubMed

      Ramisetti, Nageswara Rao; Kuntamukkala, Ramakrishna; Arnipalli, Manikanta Swamy

      2015-07-01

      Despite the availability of a few methods for individual separation of S-pramipexole from its process-related impurities, no common liquid chromatography (LC) method is reported so far in the literature. The present article describes the development of a single-run LC method for simultaneous determination of S-pramipexole and its enantiomeric and process-related impurities on a Chiralpak AD-H (150 x 4.6 mm, 5μm) column using n-hexane/ethanol/n-butylamine (75:25:0.1 v/v/v) as a mobile phase in an isocratic mode of elution at a flow rate of 1.2 ml/min at 30°C. The chromatographic eluents were monitored at a wavelength of 260 nm using a photodiode array detector. Excellent enantioseparation with good resolutions (Rs ≥ 2.88) and peak shapes (As ≤ 1.21) for all analytes was achieved. The proposed method was validated according to International Conference Harmonization (ICH) guidelines in terms of accuracy, precision, sensitivity, and linearity. Limits of quantification of impurities (0.25-0.55 μg/ml) indicate the highest sensitivity achievable by the proposed method. The method has an advantage of selectivity and suitability for routine determination of not only chiral impurity but also all possible related substances in active pharmaceutical ingredients of S-pramipexole. PMID:25966024

    6. Presence of Pre-rRNAs before Activation of Polymerase I Transcription in the Building Process of Nucleoli during Early Development of Xenopus laevis

      PubMed Central

      Verheggen, Céline; Le Panse, Sophie; Almouzni, Geneviève; Hernandez-Verdun, Danièle

      1998-01-01

      During the early development of Xenopus laevis, we followed in individual nuclei the formation of a nucleolus by examining simultaneously its structural organization and its transcriptional competence. Three distinct situations were encountered with different frequencies during development. During the first period of general transcriptional quiescence, the transcription factor UBF of maternal origin, was present in most nuclei at the ribosomal gene loci. In contrast, fibrillarin, a major protein of the processing machinery, was found in multiple prenucleolar bodies (PNBs) whereas nucleolin was dispersed largely in the nucleoplasm. During the second period, for most nuclei these PNBs had fused into two domains where nucleolin concentrated, generating a structure with most features expected from a transcriptionally competent nucleolus. However, RNA polymerase I–dependent transcription was not detected using run-on in situ assays whereas unprocessed ribosomal RNAs were observed. These RNAs were found to derive from a maternal pool. Later, during a third period, an increasing fraction of the nuclei presented RNA polymerase I–dependent transcription. Thus, the structural organization of the nucleolus preceded its transcriptional competence. We conclude that during the early development of X. laevis, the organization of a defined nucleolar structure, is not associated with the transcription process per se but rather with the presence of unprocessed ribosomal RNAs. PMID:9732279

    7. Presence of pre-rRNAs before activation of polymerase I transcription in the building process of nucleoli during early development of Xenopus laevis.

      PubMed

      Verheggen, C; Le Panse, S; Almouzni, G; Hernandez-Verdun, D

      1998-09-01

      During the early development of Xenopus laevis, we followed in individual nuclei the formation of a nucleolus by examining simultaneously its structural organization and its transcriptional competence. Three distinct situations were encountered with different frequencies during development. During the first period of general transcriptional quiescence, the transcription factor UBF of maternal origin, was present in most nuclei at the ribosomal gene loci. In contrast, fibrillarin, a major protein of the processing machinery, was found in multiple prenucleolar bodies (PNBs) whereas nucleolin was dispersed largely in the nucleoplasm. During the second period, for most nuclei these PNBs had fused into two domains where nucleolin concentrated, generating a structure with most features expected from a transcriptionally competent nucleolus. However, RNA polymerase I-dependent transcription was not detected using run-on in situ assays whereas unprocessed ribosomal RNAs were observed. These RNAs were found to derive from a maternal pool. Later, during a third period, an increasing fraction of the nuclei presented RNA polymerase I-dependent transcription. Thus, the structural organization of the nucleolus preceded its transcriptional competence. We conclude that during the early development of X. laevis, the organization of a defined nucleolar structure, is not associated with the transcription process per se but rather with the presence of unprocessed ribosomal RNAs. PMID:9732279

    8. Neurocognitive effects of HF-rTMS over the dorsolateral prefrontal cortex on the attentional processing of emotional information in healthy women: an event-related fMRI study.

      PubMed

      De Raedt, Rudi; Leyman, Lemke; Baeken, Chris; Van Schuerbeek, Peter; Luypaert, Rob; Vanderhasselt, Marie-Anne; Dannlowski, Udo

      2010-12-01

      Current evidence concerning the neurocircuitry underlying the interplay between attention and emotion is mainly correlational. We used high-frequency repetitive Transcranial Magnetic Stimulation (HF-rTMS) to experimentally manipulate activity within the right or left dorsolateral prefrontal cortex (DLPFC) of healthy women and examined changes in attentional processing of emotional information using an emotional modification of the exogenous cueing task during event-related fMRI. Right prefrontal HF-rTMS resulted in impaired disengagement from angry faces, associated with decreased activation within the right DLPFC, dorsal anterior cingulate cortex (dACC) and left superior parietal gyrus, combined with increased activity within the right amygdala. Left prefrontal HF-rTMS resulted in diminished attentional engagement by angry faces and was associated with increased activity within the right DLPFC, dACC, right superior parietal gyrus and left orbitofrontal cortex. The present observations are in line with reports of a functionally interactive network of cortical-limbic pathways that play a central role in emotion regulation. PMID:20923694

    9. How Do People Become W.E.I.R.D.? Migration Reveals the Cultural Transmission Mechanisms Underlying Variation in Psychological Processes

      PubMed Central

      Mesoudi, Alex; Magid, Kesson; Hussain, Delwar

      2016-01-01

      Cultural psychologists have shown that people from Western, Educated, Industrialised, Rich, Democratic (WEIRD) countries often exhibit different psychological processing to people from less-WEIRD countries. The former exhibit more individualistic and less collectivistic social orientation, and more analytic and less holistic cognition, than non-Westerners. Yet the mechanisms responsible for maintaining this cultural variation are unclear. Immigration is an ideal ‘natural experiment’ for uncovering such mechanisms. We used a battery of psychological measures previously shown to vary cross-culturally to compare the social orientation and cognitive style of 286 residents of East London from three cultural backgrounds: (i) 1st-generation British Bangladeshi immigrants; (ii) 2nd-generation British Bangladeshis raised in the UK to Bangladeshi-raised parents; and (iii) non-migrants whose parents were born and raised in the UK. Model comparison revealed that individualism and dispositional attribution, typical of Western societies, are driven primarily by horizontal cultural transmission (e.g. via mass media), with parents and other family members having little or no effect, while collectivism, social closeness and situational attribution were driven by a mix of vertical/oblique cultural transmission (e.g. via family contact) and horizontal cultural transmission. These individual-level transmission dynamics can explain hitherto puzzling population-level phenomena, such as the partial acculturation of 2nd-generation immigrants on measures such as collectivism (due to the mix of vertical and horizontal cultural transmission), or the observation in several countries of increasing individualism (which is transmitted horizontally and therefore rapidly) despite little corresponding change in collectivism (which is transmitted partly vertically and therefore more slowly). Further consideration of cultural transmission mechanisms, in conjunction with the study of migrant communities and model comparison statistics, can shed light on the persistence of, and changes in, culturally-variable psychological processes. PMID:26760972

    10. How Do People Become W.E.I.R.D.? Migration Reveals the Cultural Transmission Mechanisms Underlying Variation in Psychological Processes.

      PubMed

      Mesoudi, Alex; Magid, Kesson; Hussain, Delwar

      2016-01-01

      Cultural psychologists have shown that people from Western, Educated, Industrialised, Rich, Democratic (WEIRD) countries often exhibit different psychological processing to people from less-WEIRD countries. The former exhibit more individualistic and less collectivistic social orientation, and more analytic and less holistic cognition, than non-Westerners. Yet the mechanisms responsible for maintaining this cultural variation are unclear. Immigration is an ideal 'natural experiment' for uncovering such mechanisms. We used a battery of psychological measures previously shown to vary cross-culturally to compare the social orientation and cognitive style of 286 residents of East London from three cultural backgrounds: (i) 1st-generation British Bangladeshi immigrants; (ii) 2nd-generation British Bangladeshis raised in the UK to Bangladeshi-raised parents; and (iii) non-migrants whose parents were born and raised in the UK. Model comparison revealed that individualism and dispositional attribution, typical of Western societies, are driven primarily by horizontal cultural transmission (e.g. via mass media), with parents and other family members having little or no effect, while collectivism, social closeness and situational attribution were driven by a mix of vertical/oblique cultural transmission (e.g. via family contact) and horizontal cultural transmission. These individual-level transmission dynamics can explain hitherto puzzling population-level phenomena, such as the partial acculturation of 2nd-generation immigrants on measures such as collectivism (due to the mix of vertical and horizontal cultural transmission), or the observation in several countries of increasing individualism (which is transmitted horizontally and therefore rapidly) despite little corresponding change in collectivism (which is transmitted partly vertically and therefore more slowly). Further consideration of cultural transmission mechanisms, in conjunction with the study of migrant communities and model comparison statistics, can shed light on the persistence of, and changes in, culturally-variable psychological processes. PMID:26760972

    11. Simulation of self-organization processes in crystal-forming systems: Supramolecular cyclic R6 cluster precursors and self-assembly of TeO2- TEL ( Tellurite) and TeO2- PAR ( Paratellurite) structures

      NASA Astrophysics Data System (ADS)

      Ilyushin, G. D.

      2014-11-01

      The supramolecular chemistry of oxides of sp elements (SO2, SeO2, and TeO2) is considered. The self-assembly of TeO2- TEL ( Tellurite) and TeO2- PAR ( Paratellurite) crystal structures is simulated. Methods of combinatorial and topological analysis (TOPOS program package) are applied which are based on constructing a basis 3D network of the structure in the form of a graph, the sites of which correspond to the positions of centroids of TeO2 molecules and the edges characterize bonds between them. The topological type of the basis 2D network in the TeO2- TEL structure corresponds to graphite (C- GRA), while in the TeO2- PAR structure the basis network corresponds to the 3D diamond network (C- DIA). A nanocluster precursor of cyclic type ( R6) composed of six covalently bound TeO2 molecules (chair conformation) is established for both structures. The desymmetrization of the cyclic structure of the R6 cluster in TeO2- PAR is related to the formation of Te-Te bonds with lengths of 3.824 and 4.062 Å. The symmetry and topology code of the processes of self-assembly of 3D structures from nanocluster precursors is completely reconstructed into the form "primary chain → microlayer → microframework." In both structures R6 clusters form 2D packings with a coordination number of 6. The cluster self-assembly model explains the specific features of the morphogenesis of TeO2- TEL and TeO2- PAR (phases with low and high crystallization temperatures, respectively): platelike shape, perfect cleavage in the (110) plane, and preferred growth in the primar-chain direction [100] in the former case and growth in the direction of the primary [001] axis with the preferred formation of tetragonal prism faces (110) in the latter case.

    12. Mutation of EMG1 causing Bowen–Conradi syndrome results in reduced cell proliferation rates concomitant with G2/M arrest and 18S rRNA processing delay

      PubMed Central

      Armistead, Joy; Hemming, Richard; Patel, Nehal; Triggs-Raine, Barbara

      2014-01-01

      Bowen–Conradi syndrome (BCS) is a lethal autosomal recessive disorder caused by a D86G substitution in the protein, Essential for Mitotic Growth 1 (EMG1). EMG1 is essential for 18S rRNA maturation and 40S ribosome biogenesis in yeast, but no studies of its role in ribosome biogenesis have been done in mammals. To assess the effect of the EMG1 mutation on cell growth and ribosomal biogenesis in humans, we employed BCS patient cells. The D86G substitution did not interfere with EMG1 nucleolar localization. In BCS patient lymphoblasts, cells accumulated in G2/M, resulting in reduced proliferation rates; however, patient fibroblasts showed normal proliferation. The rate of 18S rRNA processing was consistently delayed in patient cells, although this did not lead to a difference in the levels of 40S ribosomes, or a change in protein synthesis rates. These results demonstrate that as in yeast, EMG1 in mammals has a role in ribosome biogenesis. The obvious phenotype in lymphoblasts compared to fibroblasts suggests a greater need for EMG1 in rapidly dividing cells. Tissue-specific effects have been seen in other ribosomal biogenesis disorders, and it seems likely that the impact of EMG1 deficiency would be larger in the rapidly proliferating cells of the developing embryo. PMID:26676230

    13. 77 FR 1656 - Proposed Establishment of Restricted Areas R-5402, R-5403A, R-5403B, R-5403C, R-5403D, R-5403E, R...

      Federal Register 2010, 2011, 2012, 2013, 2014

      2012-01-11

      ... November 28, 2011 (76 FR 72869), scheduled to close on January 12, 2012, is extended until February 12... Register published on April 11, 2000 (65 FR 19477-78) or you may visit http://DocketsInfo.dot.gov . Docket... Areas R-5402, R-5403A, R-5403B, R- 5403C, R-5403D, R-5403E, R-5403F; Devils Lake, ND (76 FR...

    14. R2R-printed inverted OPV modules - towards arbitrary patterned designs

      NASA Astrophysics Data System (ADS)

      Välimäki, M.; Apilo, P.; Po, R.; Jansson, E.; Bernardi, A.; Ylikunnari, M.; Vilkman, M.; Corso, G.; Puustinen, J.; Tuominen, J.; Hast, J.

      2015-05-01

      We describe the fabrication of roll-to-roll (R2R) printed organic photovoltaic (OPV) modules using gravure printing and rotary screen-printing processes. These two-dimensional printing techniques are differentiating factors from coated OPVs enabling the direct patterning of arbitrarily shaped and sized features into visual shapes and, increasing the freedom to connect the cells in modules. The inverted OPV structures comprise five layers that are either printed or patterned in an R2R printing process. We examined the rheological properties of the inks used and their relationship with the printability, the compatibility between the processed inks, and the morphology of the R2R-printed layers. We also evaluate the dimensional accuracy of the printed pattern, which is an important consideration in designing arbitrarily-shaped OPV structures. The photoactive layer and top electrode exhibited excellent cross-dimensional accuracy corresponding to the designed width. The transparent electron transport layer extended 300 µm beyond the designed values, whereas the hole transport layer shrank 100 µm. We also examined the repeatability of the R2R fabrication process when the active area of the module varied from 32.2 cm2 to 96.5 cm2. A thorough layer-by-layer optimization of the R2R printing processes resulted in realization of R2R-printed 96.5 cm2 sized modules with a maximum power conversion efficiency of 2.1% (mean 1.8%) processed with high functionality.

    15. R2R-printed inverted OPV modules--towards arbitrary patterned designs.

      PubMed

      Välimäki, M; Apilo, P; Po, R; Jansson, E; Bernardi, A; Ylikunnari, M; Vilkman, M; Corso, G; Puustinen, J; Tuominen, J; Hast, J

      2015-06-01

      We describe the fabrication of roll-to-roll (R2R) printed organic photovoltaic (OPV) modules using gravure printing and rotary screen-printing processes. These two-dimensional printing techniques are differentiating factors from coated OPVs enabling the direct patterning of arbitrarily shaped and sized features into visual shapes and, increasing the freedom to connect the cells in modules. The inverted OPV structures comprise five layers that are either printed or patterned in an R2R printing process. We examined the rheological properties of the inks used and their relationship with the printability, the compatibility between the processed inks, and the morphology of the R2R-printed layers. We also evaluate the dimensional accuracy of the printed pattern, which is an important consideration in designing arbitrarily-shaped OPV structures. The photoactive layer and top electrode exhibited excellent cross-dimensional accuracy corresponding to the designed width. The transparent electron transport layer extended 300 µm beyond the designed values, whereas the hole transport layer shrank 100 µm. We also examined the repeatability of the R2R fabrication process when the active area of the module varied from 32.2 cm(2) to 96.5 cm(2). A thorough layer-by-layer optimization of the R2R printing processes resulted in realization of R2R-printed 96.5 cm(2) sized modules with a maximum power conversion efficiency of 2.1% (mean 1.8%) processed with high functionality. PMID:25951787

    16. Intrusive [r] and Optimal Epenthetic Consonants

      ERIC Educational Resources Information Center

      Uffmann, Christian

      2007-01-01

      This paper argues against the view of intrusive [r] as a synchronically arbitrary insertion process. Instead, it is seen as a phonologically natural process, which can be modelled within the framework of Optimality Theory (OT). Insertion of [r] in phonologically restricted environments is a consequence of a more general theory of consonant…

    17. R parity violation from discrete R symmetries

      NASA Astrophysics Data System (ADS)

      Chen, Mu-Chun; Ratz, Michael; Takhistov, Volodymyr

      2015-02-01

      We consider supersymmetric extensions of the standard model in which the usual R or matter parity gets replaced by another R or non-R discrete symmetry that explains the observed longevity of the nucleon and solves the μ problem of MSSM. In order to identify suitable symmetries, we develop a novel method of deriving the maximal ZN(R) symmetry that satisfies a given set of constraints. We identify R parity violating (RPV) and conserving models that are consistent with precision gauge unification and also comment on their compatibility with a unified gauge symmetry such as the Pati-Salam group. Finally, we provide a counter-example to the statement found in the recent literature that the lepton number violating RPV scenarios must have μ term and the bilinear κLHu operator of comparable magnitude.

    18. Mutated hybrid inflation in f(R,□R)-gravity

      SciTech Connect

      Iihoshi, Masao

      2011-02-01

      A new hybrid inflationary scenario in the context of f(R,□R)-gravity is proposed. Demanding the waterfall field to 'support the potential from below' [unlike the original proposal by Stewart in Phys. Lett. B 345, 414 (1995)], we demonstrate that the scalar potential is similar to that of the large-field chaotic inflation model proposed by Linde in Phys. Lett. B 129, 177 (1983). Inflationary observables are used to constrain the parameter space of our model; in the process, an interesting limit on the number of e-folds N is found.

    19. Mutated hybrid inflation in f(R,squareR)-gravity

      NASA Astrophysics Data System (ADS)

      Iihoshi, Masao

      2011-02-01

      A new hybrid inflationary scenario in the context of f(R,squareR)-gravity is proposed. Demanding the waterfall field to `support the potential from below' [unlike the original proposal by Stewart in Phys. Lett. B 345, 414 (1995)], we demonstrate that the scalar potential is similar to that of the large-field chaotic inflation model proposed by Linde in Phys. Lett. B 129, 177 (1983). Inflationary observables are used to constrain the parameter space of our model; in the process, an interesting limit on the number of e-folds N is found.

    20. FINAL REPORT DETERMINATION OF THE PROCESSING RATE OF RPP WTP HLW SIMULANTS USING A DURAMELTER J 1000 VITRIFICATION SYSTEM VSL-00R2590-2 REV 0 8/21/00

      SciTech Connect

      KRUGER AA; MATLACK KS; KOT WK; PEREZ-CARDENAS F; PEGG IL

      2011-12-29

      This report provides data, analysis, and conclusions from a series of tests that were conducted at the Vitreous State Laboratory of The Catholic University of America (VSL) to determine the melter processing rates that are achievable with RPP-WTP HLW simulants. The principal findings were presented earlier in a summary report (VSL-00R2S90-l) but the present report provides additional details. One of the most critical pieces of information in determining the required size of the RPP-WTP HLW melter is the specific glass production rate in terms of the mass of glass that can be produced per unit area of melt surface per unit time. The specific glass production rate together with the waste loading (essentially, the ratio of waste-in to glass-out, which is determined from glass formulation activities) determines the melt area that is needed to achieve a given waste processing rate with due allowance for system availability. As a consequence of the limited amount of relevant information, there exists, for good reasons, a significant disparity between design-base specific glass production rates for the RPP-WTP LAW and HLW conceptual designs (1.0 MT/m{sup 2}/d and 0.4 MT/m{sup 2}/d, respectively); furthermore, small-scale melter tests with HLW simulants that were conducted during Part A indicated typical processing rates with bubbling of around 2.0 MT/m{sup 2}/d. This range translates into more than a factor of five variation in the resultant surface area of the HLW melter, which is clearly not without significant consequence. It is clear that an undersized melter is undesirable in that it will not be able to support the required waste processing rates. It is less obvious that there are potential disadvantages associated with an oversized melter, over and above the increased capital costs. A melt surface that is consistently underutilized will have poor cold cap coverage, which will result in increased volatilization from the melt (which is generally undesirable) and increased plenum temperatures due to increased thermal radiation from the melt surface (which mayor may not be desirable but the flexibility to choose may be lost). Increased volatilization is an issue both in terms of the increased challenge to the off-gas system as well as for the ability to effectively close the recycle loops for volatile species that must be immobilized in the glass product, most notably technetium and cesium. For these reasons, improved information is needed on the specific glass production rates of RPP-WTP HLW streams in DuraMelterJ systems over a range of operating conditions. Unlike the RPP-WTP LAW program, for which a pilot melter system to provide large-scale throughout information is already in operation, there is no comparable HLW activity; the results of the present study are therefore especially important. This information will reduce project risk by reducing the uncertainty associated with the amount of conservatism that mayor may not be associated with the baseline RPP-WTP HLW melter sizing decision. After the submission of the first Test Plan for this work, the RPP-WTP requested revisions to include tests to determine the processing rates that are achievable without bubbling, which was driven by the potential advantages of omitting bubblers from the HLW melter design in terms of reduced maintenance. A further objective of this effort became the determination of whether the basis of design processing rate could be achieved without bubbling. Ideally, processing rate tests would be conducted on a full-scale RPP-WTP melter system with actual HLW materials, but that is clearly unrealistic during Part B1. As a practical compromise the processing rate determinations were made with HL W simulants on a DuraMelter J system at as close to full scale as possible and the DM 1000 system at VSL was selected for that purpose. That system has a melt surface area of 1.2 m{sup 2}, which corresponds to about one-third scale based on the specific glass processing rate of 0.4 MT/m{sup 2}/d assumed in the RPP-WTP HLW conceptual design, but would correspond to larger than full scale if the typical Part A test results of about 2.0 MT/m{sup 2}/d were realized. The DM 1000 system was used with the existing off-gas treatment system in order to expedite the collection of this information; while that system is somewhat different from the RPP-WTP conceptual design, that should have no effect on the processing rate measurements. Subsequent tasks supported the later modification of that off-gas system to obtain large-scale system performance information on the baseline off-gas design and those modifications are now complete. Work planned for Part B2 includes similar pilot-scale testing with the prototypical off-gas system. Three HLW simulant compositions were used in the present tests: the tank AZ-101 waste (the first B2 HLW feed to the RPP-WTP), the 106-C/AY-102 blend (the largest B2 HLW tank), and the HLW composition processed at West Valley.

    1. Does R&D pay?

      PubMed

      Cavalla, David; Minhas, Raman

      2010-03-01

      Pharmaceutical R&D is notoriously risky, lengthy and costly; moreover, it does not always produce products of blockbuster status. The conventional route of fully discovering, developing and marketing a new chemical entity is followed by the large pharmaceutical companies, whereas other organizations in the pharmaceutical sector--such as generic or specialty companies and biotechnology companies--only operate over portions of the full R&D process. Here, we compare the ten-year financial performance of these three subsectors through their price/earnings ratios and their return on capital metrics to understand which of these strategic alternatives offered the best return to investors. PMID:19931643

    2. Factor Analysis Using "R"

      ERIC Educational Resources Information Center

      Beaujean, A. Alexander

      2013-01-01

      "R" (R Development Core Team, 2011) is a very powerful tool to analyze data, that is gaining in popularity due to its costs (its free) and flexibility (its open-source). This article gives a general introduction to using "R" (i.e., loading the program, using functions, importing data). Then, using data from Canivez, Konold, Collins, and Wilson…

    3. Dielectric Constants of Refrigerants R113, R114, R114B2, R115, R116, and R124

      NASA Astrophysics Data System (ADS)

      Kashiwagi, Hiroshi; Harada, Noboru; Tanaka, Yoshiyuki; Kubota, Hironobu; Makita, Tadashi

      The dielectric constants of six refrigerants have been measured in both gaseous and liquid phases. The fluids used and the experimental ranges of temperature and pressure are as follows : R113 (1, 2, 2- Trichlorotrifluoroethane CClF2CCl2F) : 298.15-423.15K, 0.1-17.3MPa, R1l4 (1, 2- Dichlorotetrafluoroethane CClF2CClF2) : 298.15-423.15K, 0.2-17.2MPa, R114B2 (1, 2- Dibromotetrafluoroethane CBrF2CBrF2) : 298.15-423.15K, 0.2-17.3MPa, R1l5 (Chloropentafluoroethane CClF2CF3) : 298.15 373.15K. O.1-17.1MPa, R1l6 (Hexafluoroethane CF3CF3) : 283.15-373.15 K, 0.2-16.9MPa, R124 (1-Chloro-2, 2, 2, -tetrafluoroethane CHClFCF3) : 273.15 373.15K, 0.1-10.5MPa The measurements were performed using a frequency-counting method on a relative basis with an uncertainty less than ±0.1%.The experimental results are given by polynomial equations. The smoothed value tables are also given for practical convenience. The pressure dependence of dielectric constants in liquid phase is represented by a similar expression to the Tait equation. The effects of pressure, temperature, and density on the dielectric constant and the molar polarization defined by the Clausius-Mossotti relation are discussed in term of polarity of molecules of each refrigerant.

    4. Expansion and diversification of the Populus R2R3-MYB family of transcription factors.

      PubMed

      Wilkins, Olivia; Nahal, Hardeep; Foong, Justin; Provart, Nicholas J; Campbell, Malcolm M

      2009-02-01

      The R2R3-MYB proteins comprise one of the largest families of transcription factors in plants. R2R3-MYB family members regulate plant-specific processes, such as the elaboration of specialized cell types, including xylem, guard cells, trichomes, and root hairs, and the biosynthesis of specialized branches of metabolism, including phenylpropanoid biosynthesis. As such, R2R3-MYB family members are hypothesized to contribute to the emergence of evolutionary innovations that have arisen in specific plant lineages. As a first step in determining the role played by R2R3-MYB family members in the emergence of lineage-specific innovations in the genus Populus, the entire Populus trichocarpa R2R3-MYB family was characterized. The Populus R2R3-MYB complement is much larger than that found in other angiosperms with fully sequenced genomes. Phylogenetic analyses, together with chromosome placement, showed that the expansion of the Populus R2R3-MYB family was not only attributable to whole genome duplication but also involved selective expansion of specific R2R3-MYB clades. Expansion of the Populus R2R3-MYB family prominently involved members with expression patterns that suggested a role in specific components of Populus life history, including wood formation and reproductive development. An expandable compendium of microarray-based expression data (PopGenExpress) and associated Web-based tools were developed to better enable within- and between-species comparisons of Populus R2R3-MYB gene expression. This resource, which includes intuitive graphic visualization of gene expression data across multiple tissues, organs, and treatments, is freely available to, and expandable by, scientists wishing to better understand the genome biology of Populus, an ecologically dominant and economically important forest tree genus. PMID:19091872

    5. The R2R3-Myb transcription fators of cotton: SNP characterization, chromosomal assignment, and phylogenetic analysis

      Technology Transfer Automated Retrieval System (TEKTRAN)

      The R2R3-Myb transcription factors are involved in many plant physiological and biochemical processes including regulation of trichome length and density in Arabidopsis. In cotton, Gossypium spp.,the developmental regulation of some R2R3-Myb transcription factors are related to fiber differentiatio...

    6. Process for functionalizing alkanes

      DOEpatents

      Bergman, R.G.; Janowicz, A.H.; Periana, R.A.

      1988-05-24

      Process for functionalizing saturated hydrocarbons comprises: (a) reacting said saturated hydrocarbons of the formula: R[sub 1]H wherein H represents a hydrogen atom; and R[sub 1] represents a saturated hydrocarbon radical, with a metal complex of the formula: CpRh[P(R[sub 2])[sub 3

    7. Arsenite evokes IL-6 secretion, autocrine regulation of STAT3 signaling, and miR-21 expression, processes involved in the EMT and malignant transformation of human bronchial epithelial cells

      SciTech Connect

      Luo, Fei; Xu, Yuan; Ling, Min; Zhao, Yue; Xu, Wenchao; Liang, Xiao; Jiang, Rongrong; Wang, Bairu; Bian, Qian; Liu, Qizhan

      2013-11-15

      Arsenite is an established human carcinogen, and arsenite-induced inflammation contributes to malignant transformation of cells, but the molecular mechanisms by which cancers are produced remain to be established. The present results showed that, evoked by arsenite, secretion of interleukin-6 (IL-6), a pro-inflammatory cytokine, led to the activation of STAT3, a transcription activator, and to increased levels of a microRNA, miR-21. Blocking IL-6 with anti-IL-6 antibody and inhibiting STAT3 activation reduced miR-21 expression. For human bronchial epithelial cells, cultured in the presence of anti-IL-6 antibody for 3 days, the arsenite-induced EMT and malignant transformation were reversed. Thus, IL-6, acting on STAT3 signaling, which up-regulates miR-21in an autocrine manner, contributes to the EMT induced by arsenite. These data define a link from inflammation to EMT in the arsenite-induced malignant transformation of HBE cells. This link, mediated through miRNAs, establishes a mechanism for arsenite-induced lung carcinogenesis. - Highlights: • Arsenite evokes IL-6 secretion. • IL-6 autocrine mediates STAT3 signaling and up-regulates miR-21expression. • Inflammation is involved in arsenite-induced EMT.

    8. Hearings Before the General Subcommittee on Education...Ninety-First Congress, First Session on H.R. 8809...April 29 and 30, 1969. National Science Research Data Processing and Information Retrieval System. [Complete Text of the Hearings].

      ERIC Educational Resources Information Center

      Congress of the U.S., Washington, DC. House Committee on Education and Labor.

      Reported are the hearings held on April 29 and 30, 1969 before the General Subcommittee on Education of the U.S. House of Representatives on H.R. 8809, a bill to amend Title IX of the National Defense Education Act of 1958 to provide for the establishment of a national information retrieval system for scientific and technical information. The…

    9. F(R) SUPERGRAVITY

      SciTech Connect

      Ketov, S. V.

      2010-06-23

      We review the F(R) supergravity recently proposed in Phys. Lett. B674(2009)59 and Class. and Quantum Grav. 26(2009)135006. Our construction supersymmetrizes popular f(R) theories of modified gravity in four spacetime dimensions. We use curved superspace of N = 1 Poincare supergravity in its minimal (2nd order) formulation so that our F(R) supergravity action is manifestly invariant under local N = 1 supersymmetry. We prove that the F(R) supergravity is classically equivalent to the standard N = 1 Poincare supergravity coupled to a dynamical chiral superfield, via a Legendre-Weyl transform in superspace. A Kaehler potential, a superpotential and a scalar potential of the chiral superfield are governed by a single holomorphic function. We find the conditions of vanishing cosmological constant without fine-tuning, which define a no-scale F(R) supergravity.

    10. Chiral inversion of R(-) fenoprofen and ketoprofen enantiomers in cats.

      PubMed

      Castro, E; Soraci, A; Fogel, F; Tapia, O

      2000-10-01

      The chiral inversion process is a characteristic metabolic pathway for different aryl-2-propionic acids or profens. Important variations have been observed between these individual compounds as well as between animal species. In this study, R(-) fenoprofen [R(-)FPF] and R(-) ketoprofen [R(-) KTF] were used to investigate their comparative stereoconversion in cats. After intravenous (i.v.) administration of R(-) FPF, the percentage of chiral inversion was 93.20+/-13.70%. A highly significant correlation (r: 0.978) was observed between the clearance of R(-) FPF and the chiral inversion process. After i.v. administration of R(-) KTF, the percentage of inversion was only 36.73+/-2.8%. No correlation between the clearance of R(-) KTF and this process was observed. R(-) FPF was metabolized by the pathways of thioesterification - chiral inversion processes. For R(-) KTF, the competitive metabolic pathways, glucuronidation and hydroxylation may be involved. However, these metabolic steps are saturable or less functional in cats. Moreover, the thioesterification of R(-) KTF in in vitro studies has been shown to be important in carnivores. The lack of correlation between clearance and chiral inversion process of R(-) KTF may be finally explained by deviation of thioesterification to other metabolic pathways of lipids and/or aminoacid conjugation, particulary glicine derivatives. PMID:11106999

    11. 1,2-dichlorohexafluoro-cyclobutane (1,2-c-C4F6Cl2, R-316c) a Potent Ozone Depleting Substance and Greenhouse Gas: Atmospheric Loss Processes, Lifetimes, and Ozone Depletion and Global Warming Potentials for the (E)- and (Z)- Stereoisomers

      NASA Astrophysics Data System (ADS)

      Papadimitriou, V. C.; McGillen, M. R.; Smith, S. C.; Jubb, A. M.; Portmann, R. W.; Hall, B. D.; Fleming, E. L.; Jackman, C. H.; Burkholder, J. B.

      2013-12-01

      1,2-dichlorohexafluoro-cyclobutane (1,2-c-C4F6Cl2, R-316c) is currently used in medical applications, as inhaled non-immobilizer amnesiac, in limited quantities and has recently been considered as a potential chlorofluoro/hydrofluoro-carbon replacement compound. R-316c usage is not restricted under the Montreal Protocol, although, R-316c represents a potent ozone depleting substance and greenhouse gas. In this work, a combination of laboratory studies of infrared absorption spectra, kinetic, and photolysis processes were performed for the (E)- and (Z)- stereoisomers of R-316c to enable an evaluation of their atmospheric lifetimes, ozone depletion (ODPs) and global warming potentials (GWPs). More specifically, O(1D), OH, and O3 reaction rate coefficients, as well as UV absorption spectra, including temperature dependence, and photolysis quantum yields and stable photolysis end-products were determined. The results from these studies will be presented. R-316c lifetimes and ODPs were evaluated using a 2-D atmospheric chemical model. Both isomers of R-316c were shown to be long-lived substances, primarily removed in the stratosphere by UV photolysis, with large ODPs, >0.3. A line-by-line radiative transfer model was used to calculate radiative efficiencies and, thus, GWPs. The GWPs for both isomers are substantial, ~5000 on the 100-year time horizon. In this presentation, we highlight the need for a thorough evaluation of the atmospheric processing of proposed replacement substances prior to usage and their inevitable emission into the atmosphere. The results of such studies enable policy makers to make informed decisions.

    12. 1,2-Dichlorohexafluoro-Cyclobutane (1,2-c-C4F6Cl2, R-316c) a Potent Ozone Depleting Substance and Greenhouse Gas: Atmospheric Loss Processes, Lifetimes, and Ozone Depletion and Global Warming Potentials for the (E) and (Z) stereoisomers

      NASA Technical Reports Server (NTRS)

      Papadimitriou, Vassileios C.; McGillen, Max R.; Smith, Shona C.; Jubb, Aaron M.; Portmann, Robert W.; Hall, Bradley D.; Fleming, Eric L.; Jackman, Charles H.; Burkholder, James B.

      2013-01-01

      The atmospheric processing of (E)- and (Z)-1,2-dichlorohexafluorocyclobutane (1,2-c-C4F6Cl2, R-316c) was examined in this work as the ozone depleting (ODP) and global warming (GWP) potentials of this proposed replacement compound are presently unknown. The predominant atmospheric loss processes and infrared absorption spectra of the R-316c isomers were measured to provide a basis to evaluate their atmospheric lifetimes and, thus, ODPs and GWPs. UV absorption spectra were measured between 184.95 to 230 nm at temperatures between 214 and 296 K and a parametrization for use in atmospheric modeling is presented. The Cl atom quantum yield in the 193 nm photolysis of R- 316c was measured to be 1.90 +/- 0.27. Hexafluorocyclobutene (c-C4F6) was determined to be a photolysis co-product with molar yields of 0.7 and 1.0 (+/-10%) for (E)- and (Z)-R-316c, respectively. The 296 K total rate coefficient for the O(1D) + R-316c reaction, i.e., O(1D) loss, was measured to be (1.56 +/- 0.11) × 10(exp -10)cu cm/ molecule/s and the reactive rate coefficient, i.e., R-316c loss, was measured to be (1.36 +/- 0.20) × 10(exp -10)cu cm/molecule/s corresponding to a approx. 88% reactive yield. Rate coefficient upper-limits for the OH and O3 reaction with R-316c were determined to be <2.3 × 10(exp -17) and <2.0 × 10(exp -22)cu cm/molecule/s, respectively, at 296 K. The quoted uncertainty limits are 2(sigma) and include estimated systematic errors. Local and global annually averaged lifetimes for the (E)- and (Z)-R-316c isomers were calculated using a 2-D atmospheric model to be 74.6 +/- 3 and 114.1 +/-10 years, respectively, where the estimated uncertainties are due solely to the uncertainty in the UV absorption spectra. Stratospheric photolysis is the predominant atmospheric loss process for both isomers with the O(1D) reaction making a minor, approx. 2% for the (E) isomer and 7% for the (Z) isomer, contribution to the total atmospheric loss. Ozone depletion potentials for (E)- and (Z)-R-316c were calculated using the 2-D model to be 0.46 and 0.54, respectively. Infrared absorption spectra for (E)- and (Z)-R-316c were measured at 296 K and used to estimate their radiative efficiencies (REs) and GWPs; 100-year time-horizon GWPs of 4160 and 5400 were obtained for (E)- and (Z)-R-316c, respectively. Both isomers of R-316c are shown in this work to be long-lived ozone depleting substances and potent greenhouse gases.

    13. R Tricks for Kids

      ERIC Educational Resources Information Center

      Braun, W. John; White, Bethany J. G.; Craig, Gavin

      2014-01-01

      Real-world phenomena simulation models, which can be used to engage middle-school students with probability, are described. Links to R instructional material and easy-to-use code are provided to facilitate implementation in the classroom.

    14. Test Review: Wagner, R. K., Torgesen, J. K., Rashotte, C. A., & Pearson, N. A., "Comprehensive Test of Phonological Processing-2nd Ed. (CTOPP-2)." Austin, Texas: Pro-Ed

      ERIC Educational Resources Information Center

      Dickens, Rachel H.; Meisinger, Elizabeth B.; Tarar, Jessica M.

      2015-01-01

      The Comprehensive Test of Phonological Processing-Second Edition (CTOPP-2; Wagner, Torgesen, Rashotte, & Pearson, 2013) is a norm-referenced test that measures phonological processing skills related to reading for individuals aged 4 to 24. According to its authors, the CTOPP-2 may be used to identify individuals who are markedly below their…

    15. Test Review: Wagner, R. K., Torgesen, J. K., Rashotte, C. A., & Pearson, N. A., "Comprehensive Test of Phonological Processing-2nd Ed. (CTOPP-2)." Austin, Texas: Pro-Ed

      ERIC Educational Resources Information Center

      Dickens, Rachel H.; Meisinger, Elizabeth B.; Tarar, Jessica M.

      2015-01-01

      The Comprehensive Test of Phonological Processing-Second Edition (CTOPP-2; Wagner, Torgesen, Rashotte, & Pearson, 2013) is a norm-referenced test that measures phonological processing skills related to reading for individuals aged 4 to 24. According to its authors, the CTOPP-2 may be used to identify individuals who are markedly below their

    16. Unconscious Priming According to Multiple S-R Rules

      ERIC Educational Resources Information Center

      Kiesel, Andrea; Kunde, Wilfried; Hoffmann, Joachim

      2007-01-01

      The present study investigated if unconscious primes can be processed according to different stimulus-response (S-R) rules simultaneously. Participants performed two different S-R rules, such as judging a digit as smaller or larger than five and judging a letter as vowel or consonant. These S-R rules were administered in random order and announced…

    17. QuasR: quantification and annotation of short reads in R

      PubMed Central

      Gaidatzis, Dimos; Lerch, Anita; Hahne, Florian; Stadler, Michael B.

      2015-01-01

      Summary: QuasR is a package for the integrated analysis of high-throughput sequencing data in R, covering all steps from read preprocessing, alignment and quality control to quantification. QuasR supports different experiment types (including RNA-seq, ChIP-seq and Bis-seq) and analysis variants (e.g. paired-end, stranded, spliced and allele-specific), and is integrated in Bioconductor so that its output can be directly processed for statistical analysis and visualization. Availability and implementation: QuasR is implemented in R and C/C++. Source code and binaries for major platforms (Linux, OS X and MS Windows) are available from Bioconductor (www.bioconductor.org/packages/release/bioc/html/QuasR.html). The package includes a ‘vignette’ with step-by-step examples for typical work flows. Contact: michael.stadler@fmi.ch Supplementary information: Supplementary data are available at Bioinformatics online. PMID:25417205

    18. Hydrologic Tests at Characterization Wells R-9i, R-13, R-19, R-22, and R-31

      SciTech Connect

      W.J. Stone; S. McLin

      2003-03-01

      Hydrologic information is essential for environmental efforts at Los Alamos National Laboratory. Testing at new characterization wells being drilled to the regional aquifer (''R wells'') to improve the conceptual hydrogeologic model of the Pajarito Plateau is providing such information. Drilling has been by air-rotary casing-advance or open-hole methods. Most wells are completed with multiple screens. After their construction, wells were rigorously developed by wire-brushing, bailing, followed by surging, swabbing, or jetting, and finally by pumping. These methods are effective based on field-parameter measurements and comparison of results of hydrologic testing at well R-31 before and after complete well development. We conducted field tests on various zones of saturation penetrated by the R wells to collect data needed for determining hydraulic properties. This document provides details of the design and execution of testing as well as an analysis of data for five of the new wells: R-9i, R-13, R-19, R-22, and R-31. One well was evaluated by a pumping test (R-13), another was evaluated by both straddle-packer/injection and pumping tests (R-9i), and the rest were evaluated by injection tests alone (R-19, R-22, R-31). Testing was constrained by the regional setting (complex geology and multiple zones of saturation) and well construction (multiscreen completion and the small diameter of the production casing). Packers are required for testing multiscreen wells. The small diameter of the production casing not only precludes the use of a slugger but also limits the capacity of pumps that can be used in testing, especially for the depths involved in the R wells. For example, pumping at a maximum rate of 19 gallons per minute did not significantly stress the regional aquifer at R-13. Although not slug tests, the injection tests are comparable in several ways, and analysis of data by slugtest methods is appropriate. Despite constraints, the results obtained appear valid based on (1) the care taken during test implementation and data analysis, (2) comparison of results for initial and repeated tests obtained by the same analytical method, (3) comparison of results obtained for a given test by different analytical methods, (4) comparison of results with values determined by geophysical logging in the wells and pumping tests of the same geologic units elsewhere on the plateau, and (5) comparison with hydraulic properties commonly reported for similar geologic materials outside the area. Significant contributions of this report are not only the documentation of test design, implementation, and analysis but also a comprehensive table showing the distribution of hydraulic properties for the saturated geologic units tested beneath the Pajarito Plateau. We also offer several recommendations based on testing to date. Placing screens across the water table and geologic contacts as well as employing oversized filter packs hinders testing and should be avoided. In addition, we recommend that future testing include some alternative designs and methods. Multiple methods and routine repeat testing for a given screened interval would permit comparison of results.

    19. Dr. William R. Lucas

      NASA Technical Reports Server (NTRS)

      1984-01-01

      Dr. William R. Lucas served as Marshall Space Flight Center Director from June 15, 1974 until July 3, 1986, when he retired after thirty-four years of civil service. Prior to the appointment, Lucas served as Center Deputy Director (1971-1974), Program Development Director (1968-1971), Astronautics Laboratory Director (1966-1968), and Propulsion and Vehicle Laboratory Director (1960-1966).

    20. Simulation Insights Using "R"

      ERIC Educational Resources Information Center

      Kostadinov, Boyan

      2013-01-01

      This article attempts to introduce the reader to computational thinking and solving problems involving randomness. The main technique being employed is the Monte Carlo method, using the freely available software "R for Statistical Computing." The author illustrates the computer simulation approach by focusing on several problems of…

    1. R. Burl Yarberry

      ERIC Educational Resources Information Center

      Nishimoto, Warren

      2007-01-01

      R. Burl Yarberry was born in 1920 in Pueblo, Colorado. He attended public schools in Pueblo and graduated from high school in 1938. After a year attending the Colorado School of Mines, he enlisted in the U.S. Marine Corps and served in the Pacific during World War II. Following his discharge, he earned a BA in English from Western State College of…

    2. 76 FR 72869 - Proposed Establishment of Restricted Areas R-5402, R-5403A, R-5403B, R-5403C, R-5403D, R-5403E...

      Federal Register 2010, 2011, 2012, 2013, 2014

      2011-11-28

      ...) radius around the center of R-5401, with the northern boundary adjusted to lie along the 47 45'00'' N... as R-5402, the 47 45'00'' N latitude. The western boundary would lie approximately 14 NM west of R... Department of Transportation (DOT) Regulatory Policies and Procedures (44 FR 11034; February 26, 1979);...

    3. The Ratio R{sub dp} of the quasielastic nd {yields} p(nn) to the elastic np {yields} pn charge-exchange-process yields at the proton emitting angle {theta}{sub p,lab} = 0 deg. over 0.55-2.0 GeV neutron-beam energy region. Comparison of the results with the model-dependent calculations

      SciTech Connect

      Sharov, V. I. Morozov, A. A.; Shindin, R. A.; Chernykh, E. V.; Nomofilov, A. A.; Strunov, L. N.

      2009-06-15

      Our new experimental results (see, e.g., Preprint JINR no. E1-2008-61 (Dubna, 2008)) on ratio R{sub dp} of the quasielastic charge-exchange yield at the proton emitting angle {theta}{sub p,lab} = 0 deg. for the nd {yields} p(nn) reaction to the elastic np {yields} pn charge-exchange yield were presented. The measurements were carried out at the Nuclotron of the Veksler and Baldin Laboratory of High Energies of the JINR (Dubna) at the neutron-beam kinetic energies of 0.55, 0.8, 1.0, 1.2, 1.4, 1.8, and 2.0 GeV. In this paper the comparison of the experimental R{sub dp} data with the obtained R{sub dp} calculations within the impulse approximation by using the invariant-amplitude sets from the GW/VPI phase-shift analysis is made. The R{sub dp} values calculated using the set of invariant amplitude data for the elastic np {yields} pn charge exchange at {theta}{sub p,CM} = 0 deg., agree with the experimental data. This confirmed the nd {yields} p(nn) process yield at {theta}{sub p,CM} = 0 deg. is caused by the contribution of the spin-dependent part of the elastic np {yields} pn charge-exchange reaction. Thus, it has been shown that the obtained experimental R{sub dp} results can be used for the Delta-Sigma experimental program to reduce the total ambiguity in the extraction of the amplitude real parts.

    4. Analysis of the Transcriptional Regulator GlpR, Promoter Elements, and Posttranscriptional Processing Involved in Fructose-Induced Activation of the Phosphoenolpyruvate-Dependent Sugar Phosphotransferase System in Haloferax mediterranei

      PubMed Central

      Cai, Lei; Cai, Shuangfeng; Zhao, Dahe; Wu, Jinhua; Wang, Lei; Liu, Xiaoqing; Li, Ming; Hou, Jing; Zhou, Jian; Liu, Jingfang; Han, Jing

      2014-01-01

      Among all known archaeal strains, the phosphoenolpyruvate-dependent phosphotransferase system (PTS) for fructose utilization is used primarily by haloarchaea, which thrive in hypersaline environments, whereas the molecular details of the regulation of the archaeal PTS under fructose induction remain unclear. In this study, we present a comprehensive examination of the regulatory mechanism of the fructose PTS in the haloarchaeon Haloferax mediterranei. With gene knockout and complementation, microarray analysis, and chromatin immunoprecipitation-quantitative PCR (ChIP-qPCR), we revealed that GlpR is the indispensable activator, which specifically binds to the PTS promoter (PPTS) during fructose induction. Further promoter-scanning mutation indicated that three sites located upstream of the H. mediterranei PPTS, which are conserved in most haloarchaeal PPTSs, are involved in this induction. Interestingly, two PTS transcripts (named T8 and T17) with different lengths of 5′ untranslated region (UTR) were observed, and promoter or 5′ UTR swap experiments indicated that the shorter 5′ UTR was most likely generated from the longer one. Notably, the translation efficiency of the transcript with this shorter 5′ UTR was significantly higher and the ratio of T8 (with the shorter 5′ UTR) to T17 increased during fructose induction, implying that a posttranscriptional mechanism is also involved in PTS activation. With these insights into the molecular regulation of the haloarchaeal PTS, we have proposed a working model for haloarchaea in response to environmental fructose. PMID:24334671

    5. Analysis of the transcriptional regulator GlpR, promoter elements, and posttranscriptional processing involved in fructose-induced activation of the phosphoenolpyruvate-dependent sugar phosphotransferase system in Haloferax mediterranei.

      PubMed

      Cai, Lei; Cai, Shuangfeng; Zhao, Dahe; Wu, Jinhua; Wang, Lei; Liu, Xiaoqing; Li, Ming; Hou, Jing; Zhou, Jian; Liu, Jingfang; Han, Jing; Xiang, Hua

      2014-02-01

      Among all known archaeal strains, the phosphoenolpyruvate-dependent phosphotransferase system (PTS) for fructose utilization is used primarily by haloarchaea, which thrive in hypersaline environments, whereas the molecular details of the regulation of the archaeal PTS under fructose induction remain unclear. In this study, we present a comprehensive examination of the regulatory mechanism of the fructose PTS in the haloarchaeon Haloferax mediterranei. With gene knockout and complementation, microarray analysis, and chromatin immunoprecipitation-quantitative PCR (ChIP-qPCR), we revealed that GlpR is the indispensable activator, which specifically binds to the PTS promoter (PPTS) during fructose induction. Further promoter-scanning mutation indicated that three sites located upstream of the H. mediterranei PPTS, which are conserved in most haloarchaeal PPTSs, are involved in this induction. Interestingly, two PTS transcripts (named T8 and T17) with different lengths of 5' untranslated region (UTR) were observed, and promoter or 5' UTR swap experiments indicated that the shorter 5' UTR was most likely generated from the longer one. Notably, the translation efficiency of the transcript with this shorter 5' UTR was significantly higher and the ratio of T8 (with the shorter 5' UTR) to T17 increased during fructose induction, implying that a posttranscriptional mechanism is also involved in PTS activation. With these insights into the molecular regulation of the haloarchaeal PTS, we have proposed a working model for haloarchaea in response to environmental fructose. PMID:24334671

    6. Hydrological analysis in R: Topmodel and beyond

      NASA Astrophysics Data System (ADS)

      Buytaert, W.; Reusser, D.

      2011-12-01

      R is quickly gaining popularity in the hydrological sciences community. The wide range of statistical and mathematical functionality makes it an excellent tool for data analysis, modelling and uncertainty analysis. Topmodel was one of the first hydrological models being implemented as an R package and distributed through R's own distribution network CRAN. This facilitated pre- and postprocessing of data such as parameter sampling, calculation of prediction bounds, and advanced visualisation. However, apart from these basic functionalities, the package did not use many of the more advanced features of the R environment, especially from R's object oriented functionality. With R's increasing expansion in arenas such as high performance computing, big data analysis, and cloud services, we revisit the topmodel package, and use it as an example of how to build and deploy the next generation of hydrological models. R provides a convenient environment and attractive features to build and couple hydrological - and in extension other environmental - models, to develop flexible and effective data assimilation strategies, and to take the model beyond the individual computer by linking into cloud services for both data provision and computing. However, in order to maximise the benefit of these approaches, it will be necessary to adopt standards and ontologies for model interaction and information exchange. Some of those are currently being developed, such as the OGC web processing standards, while other will need to be developed.

    7. Hydrologic Tests at Characterization Wells R-9i, R-13, R-19, R-22, and R-31, Revision 1

      SciTech Connect

      S.G.McLin; W.J. Stone

      2004-06-01

      Hydrologic information is essential for environmental efforts at Los Alamos National Laboratory. Testing at new characterization wells being drilled to the regional aquifer (''R wells'') to improve the conceptual hydrogeologic model of the Pajarito Plateau is providing such information. Field tests were conducted on various zones of saturation penetrated by the R wells to collect data needed for determining hydraulic properties. This document provides details of the design and execution of testing as well as an analysis of data for five new wells: R-9i, R-13, R-19, R-22, and R-31. One well (R-13) was evaluated by a pumping test and the rest (R-9i, R-19, R-22, and R-31) were evaluated by injection tests. Characterization well R-9i is located in Los Alamos Canyon approximately 0.3 mi west of the Route 4/Route 502 intersection. It was completed at a depth of 322 ft below ground surface (bgs) in March 2000. This well was constructed with two screens positioned below the regional water table. Both screens were tested. Screen 1 is completed at about 189-200 ft bgs in fractured basalt, and screen 2 is completed at about 270-280 ft bgs in massive basalt. Specific capacity analysis of the screen 1 data suggests that the fractured basalt has a transmissivity (T) of 589 ft{sup 2}/day and corresponds to a hydraulic conductivity (K) of 7.1 ft/day based on a saturated thickness of 83 ft. The injection test data from the massive basalt near screen 2 were analyzed by the Bouwer-Rice slug test methodology and suggest that K is 0.11 ft/day, corresponding to a T of about 2.8 ft{sup 2}/day based on a saturated thickness of 25 ft. Characterization well R-13 is located in Mortandad Canyon just west of the eastern Laboratory boundary. It was completed at a depth of 1029 ft bgs in February 2002. This well was constructed with one 60-ft long screen positioned about 125 ft below the regional water table. This screen is completed at about 958-1019 ft bgs and straddles the geologic contact between the Puye fanglomerate and unassigned pumiceous units. The specific capacity analysis of a 12 minute pumping test indicates that the Puye fanglomerates near the R-13 screen have a T of 5269 ft{sup 2}/day and correspond to a hydraulic conductivity (K) of 17.6 ft/day based on a saturated thickness of 300 ft. Characterization well R-19 is located east of firing site IJ in Technical Area (TA) 36 on the mesa between Three-mile and Potrillo Canyons. It was completed at a depth of 1885 ft bgs in April 2000. This well was constructed with two screens positioned above the regional water table and five screens positioned below the regional water table. Only the bottom two screens were tested. Screen 6 is completed at about 1727-1734 ft bgs in Puye fanglomerate, and screen 7 is completed at about 1832-1849 ft bgs in Puye fanglomerate. Specific capacity analysis of the screen 6 data suggests that T is about 6923 ft{sup 2}/day and corresponds to a K of 18.6 ft/day based on a saturated thickness of 373 ft. Specific capacity analysis of the screen 7 data suggests that T is about 8179 ft{sup 2}/day and corresponds to a K of 22.0 ft/day based on a saturated thickness of 373 ft. Characterization well R-22 is located on Mesita del Buey between Canada del Buey and Pajarito Canyons immediately east of Material Disposal Area (MDA) G in TA-54. It was completed at a depth of 1489 ft bgs in October 2000. This well was constructed with five screens positioned at or below the regional water table; however, only screens 2-5 were tested. Screen 1 is completed at the regional water table at about 872-914 ft bgs in Cerros del Rio basalt. Screen 2 is completed at about 947-989 ft bgs in Cerros del Rio basalt. Screen 3 is completed at about 1272-1279 ft bgs in Puye fanglomerate. Screen 4 is completed at about 1378-1452 ft bgs in older basalt. Screen 5 is completed at about 1447-1452 ft bgs in older fanglomerate. Bouwer-Rice analyses of the injection-test recovery data suggest K values of 0.04, 0.32, 0.54, and 0.27 ft/day for screens 2, 3, 4, and 5, respectively. These values correspond to T values of 2.8, 15.8, 26.5, and 11.6 ft{sup 2}/day, respectively, for screens 2, 3, 4, and 5. These analyses are based on saturated thicknesses of 69.5 ft, 49.4 ft, 49.0 ft, and 43.0 ft, respectively. Characterization well R-31 is located at TA-39 in the north fork of lower Ancho Canyon. It was completed at a depth of 1103 ft bgs in April 2000. This well was constructed with one screen positioned above the regional water table, and four screens position at or below the regional water table.

    8. Use of rRNA gene restriction patterns to evaluate lactic acid bacterium contamination of vacuum-packaged sliced cooked whole-meat product in a meat processing plant.

      PubMed

      Björkroth, K J; Korkeala, H J

      1997-02-01

      Molecular typing was applied to an in-plant lactic acid bacterium (LAB) contamination analysis of a vacuum-packaged sliced cooked whole-meat product. A total of 982 LAB isolates from the raw mass, product, and the environment at different production stages were screened by restriction endonuclease (EcoRI and HindIII) analysis. rRNA gene restriction patterns were further determined for different strains obtained from each source. These patterns were used for recognizing the spoilage-causing LAB strains from the product on the sell-by day and tracing the sources and sites of spoilage LAB contamination during the manufacture. LAB typing resulted in 71 different ribotypes, of which 27 were associated with contamination routes. Raw material was distinguished as the source of the major spoilage strains. Contamination of the product surfaces after cooking was shown to be airborne. The removal of the product from the cooking forms was localized as a major site of airborne LAB contamination. Food handlers and some surfaces in contact with the product during the manufacture were also contaminated with the spoilage strains. Some LAB strains were also able to resist cooking in the core of the product bar. These strains may have an effect on the product shelf life by contaminating the slicing machine. The air in the slicing department and adjacent cold room contained very few LAB. Surface-mediated contamination was detected during the slicing and packaging stages. Food handlers also carried strains later found in the packaged product. Molecular typing provided useful information revealing the LAB contamination sources and sites of this product. The production line will be reorganized in accordance with these results to reduce spoilage LAB contamination. PMID:9023922

    9. Competitive regulation of nucleolin expression by HuR and miR-494.

      PubMed

      Tominaga, Kumiko; Srikantan, Subramanya; Lee, Eun Kyung; Subaran, Sarah S; Martindale, Jennifer L; Abdelmohsen, Kotb; Gorospe, Myriam

      2011-10-01

      The RNA-binding protein (RBP) nucleolin promotes the expression of several proliferative proteins. Nucleolin levels are high in cancer cells, but the mechanisms that control nucleolin expression are unknown. Here, we show that nucleolin abundance is controlled posttranscriptionally via factors that associate with its 3' untranslated region (3'UTR). The RBP HuR was found to interact with the nucleolin (NCL) 3'UTR and specifically promoted nucleolin translation without affecting nucleolin mRNA levels. In human cervical carcinoma HeLa cells, analysis of a traceable NCL 3'UTR bearing MS2 RNA hairpins revealed that NCL RNA was mobilized to processing bodies (PBs) after silencing HuR, suggesting that the repression of nucleolin translation may occur in PBs. Immunoprecipitation of MS2-tagged NCL 3'UTR was used to screen for endogenous repressors of nucleolin synthesis. This search identified miR-494 as a microRNA that potently inhibited nucleolin expression, enhanced NCL mRNA association with argonaute-containing complexes, and induced NCL RNA transport to PBs. Importantly, miR-494 and HuR functionally competed for modulation of nucleolin expression. Moreover, the promotion of cell growth previously attributed to HuR was due in part to the HuR-elicited increase in nucleolin expression. Our collective findings indicate that nucleolin expression is positively regulated by HuR and negatively regulated via competition with miR-494. PMID:21859890

    10. 75 FR 68970 - Amendment of Using Agency for Restricted Areas R-4002, R-4005, R-4006 and R-4007; MD

      Federal Register 2010, 2011, 2012, 2013, 2014

      2010-11-10

      ... follows: Authority: 49 U.S.C. 106(g), 40103, 40113, 40120; E.O. 10854, 24 FR 9565, 3 CFR, 1959-1963 Comp... 12866; (2) is not a ``significant rule'' under DOT Regulatory Policies and Procedures (44 FR 11034... Restricted Areas R-4002, R-4005, R- 4006 and R-4007; MD AGENCY: Federal Aviation Administration (FAA),...

    11. Dynamical R-parity violation.

      PubMed

      Csáki, Csaba; Kuflik, Eric; Volansky, Tomer

      2014-04-01

      We present a new paradigm for supersymmetric theories with R-parity violation (RPV). At high scale, R parity is conserved in the visible sector but spontaneously broken in the supersymmetry-breaking sector. The breaking is then dynamically mediated to the visible sector and is manifested via nonrenormalizable operators at low energy. Consequently, RPV operators originate from the Kähler potential rather than the superpotential, and are naturally suppressed by the supersymmetry-breaking scale, explaining their small magnitudes. A new set of nonholomorphic RPV operators is identified and found to often dominate over the standard RPV ones. We study the relevant low-energy constraints arising from baryon-number violating processes, proton decay, and flavor changing neutral currents, which may all be satisfied if a solution to the standard model flavor puzzle is incorporated. The chiral structure of the RPV operators implies new and distinct collider signatures, indicating the need to alter current techniques in searching for RPV at the LHC. PMID:24745404

    12. Fo(u)r Women.

      PubMed

      Agbebiyi, A

      1998-01-01

      Abstract This piece is about Fo(u)r Women, a collaborative poly-vocal performance piece featuring music, poetry, prose and movement. It traces the journey from feeling through idea to actualization of a collaborative creative project: how to make a piece of Live Art from the experience of listening to a Nina Simone song and three lives. Dream, breath, hope, wish, act a prayer to you to reach out to touch Four women made flesh in a place of revelation.· In the essay, I explore aspects of process, collaboration, critical context and issues informing the art. Issues of race, gender, sexual identities, relationships, love and place. Dear reader, for those of you at home, it's like you were there, all the time it was being made. But to feel the show, you really have to see it. PMID:24785522

    13. rMPI

      Energy Science and Technology Software Center (ESTSC)

      2010-08-24

      As high-performance computing (HPC) machines continue to grow in size, issues such as fault tolerance and reliability limit application scalability. Current techniques to ensure progress across faults, like checkpoint-restart, are unsuitable on their own for exascale machines due to the excessive overheads predicted to more than double an applications time to solution. An alternative mechanism to increase application reliability than just checkpoint-restart alone is redundant computation. The rMPl library enables portable and transparent redundant computation)more » that, at extreme scale, has significantly lower verhead then just checkpoint-restart on its own.« less

    14. Rolling Deck to Repository (R2R): Fleetwide Standard Underway Data Products

      NASA Astrophysics Data System (ADS)

      Sweeney, A. D.; Clark, P. D.; Miller, S. P.; Stocks, K.; Arko, R. A.; Ferrini, V.

      2009-12-01

      The Rolling Deck to Repository (R2R) project was recently launched with the ambitious goal of documenting “routine underway data” from the US academic research fleet and delivering those data to established national archives. Data distributions will be submitted by 18 operating institutions for 30 vessels, from hundreds of cruises per year. R2R will be responsible for digital data collected with instruments that are part of the ship’s permanent equipment and are routinely operated and recorded by the ship’s technicians. Examples include navigation, multibeam, subbottom, gravimeter, magnetics, ADCP, CTD, meteorology, etc. It is anticipated that most underway data will be promptly and publicly released. However R2R will have the ability to securely embargo any specific datasets identified in advance by the chief scientist, for a proprietary hold period of up to two years as mandated by the NSF 04-004 Division of Ocean Sciences Data and Sample Policy. It is important to note that there are data types that R2R will not address. For example, the chief scientist will continue to be responsible for the documentation and archiving of data from specific instruments brought on board by the scientific party, not part of the ship’s standard equipment. Similarly, data collected with National Facility assets including the National Deep Submergence Facility (NDSF), Ocean Bottom Seismograph Instrument Pool (OBSIP) and the National Marine Seismic Facility (NMSF) will continue to be submitted to the appropriate archiving facility directly by those facilities, rather than through R2R. Soon after the shipboard data is received by R2R, the entire original distribution will be safely stored in a deep archive for long-term preservation, and a cataloging process will be undertaken to assemble data sets for delivery to National Data Centers, as described more fully in the invited presentation by Robert Arko, “Rolling Deck to Repository: Technical Design - Experiences and Lessons.” A suite of R2R standard products will be generated for each cruise including (1) Basic Cruise Metadata, (2) Operations Report, and (3) Quality Controlled Navigational Products. Certified R2R navigation will be created at three levels: NavHiRes at the original raw sample rate (usually one sample per second), Nav1Min at a standard 1-minute time interval, and NavControl at a reduced rate appropriate for graphical representation of a cruise at a global or regional scale. These standard data products will be made available for automatic harvesting on www.rvdata.us by repository and data systems, and for download by individual users.

    15. Information Commons for Rice (IC4R).

      PubMed

      2016-01-01

      Rice is the most important staple food for a large part of the world's human population and also a key model organism for plant research. Here, we present Information Commons for Rice (IC4R; http://ic4r.org), a rice knowledgebase featuring adoption of an extensible and sustainable architecture that integrates multiple omics data through community-contributed modules. Each module is developed and maintained by different committed groups, deals with data collection, processing and visualization, and delivers data on-demand via web services. In the current version, IC4R incorporates a variety of rice data through multiple committed modules, including genome-wide expression profiles derived entirely from RNA-Seq data, resequencing-based genomic variations obtained from re-sequencing data of thousands of rice varieties, plant homologous genes covering multiple diverse plant species, post-translational modifications, rice-related literatures and gene annotations contributed by the rice research community. Unlike extant related databases, IC4R is designed for scalability and sustainability and thus also features collaborative integration of rice data and low costs for database update and maintenance. Future directions of IC4R include incorporation of other omics data and association of multiple omics data with agronomically important traits, dedicating to build IC4R into a valuable knowledgebase for both basic and translational researches in rice. PMID:26519466

    16. Information Commons for Rice (IC4R)

      PubMed Central

      2016-01-01

      Rice is the most important staple food for a large part of the world's human population and also a key model organism for plant research. Here, we present Information Commons for Rice (IC4R; http://ic4r.org), a rice knowledgebase featuring adoption of an extensible and sustainable architecture that integrates multiple omics data through community-contributed modules. Each module is developed and maintained by different committed groups, deals with data collection, processing and visualization, and delivers data on-demand via web services. In the current version, IC4R incorporates a variety of rice data through multiple committed modules, including genome-wide expression profiles derived entirely from RNA-Seq data, resequencing-based genomic variations obtained from re-sequencing data of thousands of rice varieties, plant homologous genes covering multiple diverse plant species, post-translational modifications, rice-related literatures and gene annotations contributed by the rice research community. Unlike extant related databases, IC4R is designed for scalability and sustainability and thus also features collaborative integration of rice data and low costs for database update and maintenance. Future directions of IC4R include incorporation of other omics data and association of multiple omics data with agronomically important traits, dedicating to build IC4R into a valuable knowledgebase for both basic and translational researches in rice. PMID:26519466

    17. The r-Java 2.0 code: nuclear physics

      NASA Astrophysics Data System (ADS)

      Kostka, M.; Koning, N.; Shand, Z.; Ouyed, R.; Jaikumar, P.

      2014-08-01

      Aims: We present r-Java 2.0, a nucleosynthesis code for open use that performs r-process calculations, along with a suite of other analysis tools. Methods: Equipped with a straightforward graphical user interface, r-Java 2.0 is capable of simulating nuclear statistical equilibrium (NSE), calculating r-process abundances for a wide range of input parameters and astrophysical environments, computing the mass fragmentation from neutron-induced fission and studying individual nucleosynthesis processes. Results: In this paper we discuss enhancements to this version of r-Java, especially the ability to solve the full reaction network. The sophisticated fission methodology incorporated in r-Java 2.0 that includes three fission channels (beta-delayed, neutron-induced, and spontaneous fission), along with computation of the mass fragmentation, is compared to the upper limit on mass fission approximation. The effects of including beta-delayed neutron emission on r-process yield is studied. The role of Coulomb interactions in NSE abundances is shown to be significant, supporting previous findings. A comparative analysis was undertaken during the development of r-Java 2.0 whereby we reproduced the results found in the literature from three other r-process codes. This code is capable of simulating the physical environment of the high-entropy wind around a proto-neutron star, the ejecta from a neutron star merger, or the relativistic ejecta from a quark nova. Likewise the users of r-Java 2.0 are given the freedom to define a custom environment. This software provides a platform for comparing proposed r-process sites.

    18. Ceramic fabrication R D

      SciTech Connect

      Not Available

      1990-01-01

      This project is separated into three tasks. The first task is a design and modeling effort to be carried out by MSE, Inc. The purpose of this task is to develop and analyze designs for various cohesive ceramic fabrication (CCF) components. This quarter, the advanced molybdenum disicilide MHD electrode design was essentially completed. Final refinements will be made after molybdenum disilicide processing results are available and the final layer compositions are established. Work involving whisker incorporation was initiated on the high stress component. It is unlikely that whiskers will become low cost, so particulate reinforcement will be pursued. Modeling work will resume once a suitable aluminum oxide/silicon carbide composition is selected that can be fired to acceptable densities by pressureless sintering. Task 2, subcontracted to Applied Technology Laboratories (ATL), is principally directed at establishing a property data base for monolithic and laminated alumina fabricated using the CCF process. This quarter, ATL demonstrated that the CCF process does not compromise the flexure strength of alumina. Task 3, subcontracted to Ceramics Binder Systems, Inc., focused on CCF silicon carbide particulate reinforced alumina and on the development of processing procedures for nonoxide molybdenum disilicide. Preliminary results indicate that achieving high densities in silicon carbide particulate reinforced aluminum oxide will be difficult. Molybdenum disilicide results are encouraging, and it is clear that the CCF process will work with this nonoxide material. 3 refs., 18 figs., 4 tabs.

    19. R-body-producing bacteria.

      PubMed Central

      Pond, F R; Gibson, I; Lalucat, J; Quackenbush, R L

      1989-01-01

      Until 10 years ago, R bodies were known only as diagnostic features by which endosymbionts of paramecia were identified as kappa particles. They were thought to be limited to the cytoplasm of two species in the Paramecium aurelia species complex. Now, R bodies have been found in free-living bacteria and other Paramecium species. The organisms now known to form R bodies include the cytoplasmic kappa endosymbionts of P. biaurelia and P. tetraurelia, the macronuclear kappa endosymbionts of P. caudatum, Pseudomonas avenae (a free-living plant pathogen), Pseudomonas taeniospiralis (a hydrogen-oxidizing soil microorganism), Rhodospirillum centenum (a photosynthetic bacterium), and a soil bacterium, EPS-5028, which is probably a pseudomonad. R bodies themselves fall into five distinct groups, distinguished by size, the morphology of the R-body ribbons, and the unrolling behavior of wound R bodies. In recent years, the inherent difficulties in studying the organization and assembly of R bodies by the obligate endosymbiont kappa, have been alleviated by cloning and expressing genetic determinants for these R bodies (type 51) in Escherichia coli. Type 51 R-body synthesis requires three low-molecular-mass polypeptides. One of these is modified posttranslationally, giving rise to 12 polypeptide species, which are the major structural subunits of the R body. R bodies are encoded in kappa species by extrachromosomal elements. Type 51 R bodies, produced in Caedibacter taeniospiralis, are encoded by a plasmid, whereas bacteriophage genomes probably control R-body synthesis in other kappa species. However, there is no evidence that either bacteriophages or plasmids are present in P. avenae or P. taeniospiralis. No sequence homology was detected between type 51 R-body-encoding DNA and DNA from any R-body-producing species, except C. varicaedens 1038. The evolutionary relatedness of different types of R bodies remains unknown. Images PMID:2651865

    20. LuxR solos in Photorhabdus species

      PubMed Central

      Brameyer, Sophie; Kresovic, Darko; Bode, Helge B.; Heermann, Ralf

      2014-01-01

      Bacteria communicate via small diffusible molecules to mediate group-coordinated behavior, a process designated as quorum sensing. The basic molecular quorum sensing system of Gram-negative bacteria consists of a LuxI-type autoinducer synthase producing acyl-homoserine lactones (AHLs) as signaling molecules, and a LuxR-type receptor detecting the AHLs to control expression of specific genes. However, many proteobacteria possess one or more unpaired LuxR-type receptors that lack a cognate LuxI-like synthase, referred to as LuxR solos. The enteric and insect pathogenic bacteria of the genus Photorhabdus harbor an extraordinarily high number of LuxR solos, more than any other known bacteria, and all lack a LuxI-like synthase. Here, we focus on the presence and the different types of LuxR solos in the three known Photorhabdus species using bioinformatics analyses. Generally, the N-terminal signal-binding domain (SBD) of LuxR-type receptors sensing AHLs have a motif of six conserved amino acids that is important for binding and specificity of the signaling molecule. However, this motif is altered in the majority of the Photorhabdus-specific LuxR solos, suggesting the use of other signaling molecules than AHLs. Furthermore, all Photorhabdus species contain at least one LuxR solo with an intact AHL-binding motif, which might allow the ability to sense AHLs of other bacteria. Moreover, all three species have high AHL-degrading activity caused by the presence of different AHL-lactonases and AHL-acylases, revealing a high quorum quenching activity against other bacteria. However, the majority of the other LuxR solos in Photorhabdus have a N-terminal so-called PAS4-domain instead of an AHL-binding domain, containing different amino acid motifs than the AHL-sensors, which potentially allows the recognition of a highly variable range of signaling molecules that can be sensed apart from AHLs. These PAS4-LuxR solos are proposed to be involved in host sensing, and therefore in inter-kingdom signaling. Overall, Photorhabdus species are perfect model organisms to study bacterial communication via LuxR solos and their role for a symbiotic and pathogenic life style. PMID:25478328

    1. LuxR solos in Photorhabdus species.

      PubMed

      Brameyer, Sophie; Kresovic, Darko; Bode, Helge B; Heermann, Ralf

      2014-01-01

      Bacteria communicate via small diffusible molecules to mediate group-coordinated behavior, a process designated as quorum sensing. The basic molecular quorum sensing system of Gram-negative bacteria consists of a LuxI-type autoinducer synthase producing acyl-homoserine lactones (AHLs) as signaling molecules, and a LuxR-type receptor detecting the AHLs to control expression of specific genes. However, many proteobacteria possess one or more unpaired LuxR-type receptors that lack a cognate LuxI-like synthase, referred to as LuxR solos. The enteric and insect pathogenic bacteria of the genus Photorhabdus harbor an extraordinarily high number of LuxR solos, more than any other known bacteria, and all lack a LuxI-like synthase. Here, we focus on the presence and the different types of LuxR solos in the three known Photorhabdus species using bioinformatics analyses. Generally, the N-terminal signal-binding domain (SBD) of LuxR-type receptors sensing AHLs have a motif of six conserved amino acids that is important for binding and specificity of the signaling molecule. However, this motif is altered in the majority of the Photorhabdus-specific LuxR solos, suggesting the use of other signaling molecules than AHLs. Furthermore, all Photorhabdus species contain at least one LuxR solo with an intact AHL-binding motif, which might allow the ability to sense AHLs of other bacteria. Moreover, all three species have high AHL-degrading activity caused by the presence of different AHL-lactonases and AHL-acylases, revealing a high quorum quenching activity against other bacteria. However, the majority of the other LuxR solos in Photorhabdus have a N-terminal so-called PAS4-domain instead of an AHL-binding domain, containing different amino acid motifs than the AHL-sensors, which potentially allows the recognition of a highly variable range of signaling molecules that can be sensed apart from AHLs. These PAS4-LuxR solos are proposed to be involved in host sensing, and therefore in inter-kingdom signaling. Overall, Photorhabdus species are perfect model organisms to study bacterial communication via LuxR solos and their role for a symbiotic and pathogenic life style. PMID:25478328

    2. Becoming A/r/tography

      ERIC Educational Resources Information Center

      Irwin, Rita L.

      2013-01-01

      This article explores moments of becoming a/r/tography. A/r/tography is a research methodology, a creative practice, and a performative pedagogy that lives in the rhizomatic practices of the in-between. Resisting the tendency for endless critique of past experience and bodies of knowledge, a/r/tography is concerned with the creative invention of…

    3. Transparent runtime parallelization of the R scripting language

      SciTech Connect

      Yoginath, Srikanth B

      2011-01-01

      Scripting languages such as R and Matlab are widely used in scientific data processing. As the data volume and the complexity of analysis tasks both grow, sequential data processing using these tools often becomes the bottleneck in scientific workflows. We describe pR, a runtime framework for automatic and transparent parallelization of the popular R language used in statistical computing. Recognizing scripting languages interpreted nature and data analysis codes use pattern, we propose several novel techniques: (1) applying parallelizing compiler technology to runtime, whole-program dependence analysis of scripting languages, (2) incremental code analysis assisted with evaluation results, and (3) runtime parallelization of file accesses. Our framework does not require any modification to either the source code or the underlying R implementation. Experimental results demonstrate that pR can exploit both task and data parallelism transparently and overall has better performance as well as scalability compared to an existing parallel R package that requires code modification.

    4. The First Two R's.

      ERIC Educational Resources Information Center

      Tzeng, Ovid J. L.; Wang, William S. Y.

      1983-01-01

      Indicates that the way different languages reduce speech to script affects how visual information is processed in the brain, suggesting that the relation between script and speech underlying all types of writing systems plays an important part in reading behavior. Compares memory performance of native English/Chinese speakers. (JN)

    5. In-situ defect detection systems for R2R flexible PV barrier films

      NASA Astrophysics Data System (ADS)

      Gao, F.; Muhamedsalih, H.; Tang, D.; Elrawemi, M.; Blunt, L.; Jiang, X.; Edge, S.; Bird, D.; Hollis, P.

      2015-08-01

      Film processing procedures by means of Roll-to-Roll (R2R) for barrier coatings can often result in PV barrier films being manufactured with significant quantities of defects, which results in lower efficiency and a short life span. In order to improve the process yield and product efficiency, it is desirable to develop an inspection system that can detect transparent barrier film defects in the production line during film processing. Off-line detection of defects in transparent PV barrier films is difficult and time consuming. Consequently, implementing an accurate in-situ defects inspection system in the production environment is even more challenging, since the requirements on positioning, fast measurement, long term stability and robustness against environmental disturbance are demanding. This paper reports on the development and deployment of two in-situ PV barrier films defect detection systems, one based on wavelength scanning interferometry (WSI) and the other on White Light Channeled Spectral Interferometry (WLCSI), and the integration into an R2R film processing line at the Centre for Process Innovation (CPI). The paper outlines the environmental vibration strategy for both systems, and the developed auto-focusing methodology for WSI. The systems have been tested and characterised and initial results compared to laboratory-based instrumentation are presented.

    6. Insilico study of the A(2A)R-D (2)R kinetics and interfacial contact surface for heteromerization.

      PubMed

      Prakash, Amresh; Luthra, Pratibha Mehta

      2012-10-01

      G-protein-coupled receptors (GPCRs) are cell surface receptors. The dynamic property of receptor-receptor interactions in GPCRs modulates the kinetics of G-protein signaling and stability. In the present work, the structural and dynamic study of A(2A)R-D(2)R interactions was carried to acquire the understanding of the A(2A)R-D(2)R receptor activation and deactivation process, facilitating the design of novel drugs and therapeutic target for Parkinson's disease. The structure-based features (Alpha, Beta, SurfAlpha, and SurfBeta; GapIndex, Leakiness and Gap Volume) and slow mode model (ENM) facilitated the prediction of kinetics (K (off), K (on), and K (d)) of A(2A)R-D(2)R interactions. The results demonstrated the correlation coefficient 0.294 for K (d) and K (on) and the correlation coefficient 0.635 for K (d) and K (off), and indicated stable interfacial contacts in the formation of heterodimer. The coulombic interaction involving the C-terminal tails of the A(2A)R and intracellular loops (ICLs) of D(2)R led to the formation of interfacial contacts between A(2A)R-D(2)R. The properties of structural dynamics, ENM and KFC server-based hot-spot analysis illustrated the stoichiometry of A(2A)R-D(2)R contact interfaces as dimer. The propensity of amino acid residues involved in A(2A)R-D(2)R interaction revealed the presence of positively (R, H and K) and negatively (E and D) charged structural motif of TMs and ICL3 of A(2A)R and D(2)R at interface of dimer contact. Essentially, in silico structural and dynamic study of A(2A)R-D(2)R interactions will provide the basic understanding of the A(2A)R-D(2)R interfacial contact surface for activation and deactivation processes, and could be used as constructive model to recognize the protein-protein interactions in receptor assimilations. PMID:22278740

    7. Lee R. Scherer

      NASA Technical Reports Server (NTRS)

      1980-01-01

      Lee R. Scherer was appointed Director of the NASA Flight Research Center on October 11, 1971, a position he held until January 28, 1975. Mr. Scherer first worked with NASA in 1962 while still on active duty with the U.S. Navy as a Captain. Prior to his arriving at the Flight Research Center he was at NASA Headquarters' Office of Space Science and Applications, as Director of the Apollo Program for the scientific aspects of lunar explorations, Assistant Director of Lunar Programs, and Manager of the Lunar Orbiter Program from its inception in 1963 through its successful completion in 1967. Scherer graduated from the U.S. Naval Academy in 1942. Most of Lee's 25-year Naval career was spent in aviation, including a tour flying carrier-based fighters and flight test experience with helicopters. Prior to entering the Naval Academy, he attended the University of Kentucky for one year. He received a second Bachelor of Science degree in aeronautical engineering in 1949 from the U.S. Naval Postgraduate School and his Master's degree in aeronautical engineering from the California Institute of Technology (Caltech) in 1950. Lee also attended the Summer of Industrial Management Studies program at the University of California at Los Angeles in 1949. Awards he has received include the NASA's Exceptional Service Medal in 1967 and NASA's Exceptional Scientific Achievement Medal in 1969.

    8. Ceramic fabrication R D

      SciTech Connect

      Not Available

      1990-01-01

      This project is separated into three tasks. The first task is a design and modelling effort to be carried out by MSE, Inc. The purpose of this task is to develop and analyze designs for various cohesive ceramic fabrication (CCF) components, principally an MHD electrode for strategic defense initiative (SDI) applications. A high stress, low cost, ceramic component is to be selected, designed and, if possible, analyzed. The final design for the MHD electrode comprised a layered structure of molybdenum disilicide graded with quartz glass. The design demonstrates the fabrication capabilities of the CCF process. The high stress component was targeted at armor applications and will be thick alumina plate. Silicon carbide reinforcement of the alumina will be explored. Task 2 is directed at establishing a mechanical properties data base for monolithic and laminated alumina fabricated using the CCF process. Task 3 involved production of a solid oxide fuel cell model electrode; however, work ceased when it became apparent that successful integration of the electrode modules would require additional time. Currently, work is principally focused on the production of thick CCF alumina plates; three test plates were ballistically tested and showed a very satisfactory performance. Silicon carbide reinforcement of the CCF alumina is being explored. Effort on the CCF processing of molybdenum disilicide (a nonoxide material) continued at a reduced level. Sinter aids were explored, and densities of 87% theoretical density on pressureless sintered dry pressed pellets were achieved. 1 ref., 9 figs., 4 tabs.

    9. Craig R. Bomben

      NASA Technical Reports Server (NTRS)

      2001-01-01

      Craig R. Bomben became a pilot in the Flight Crew Branch of NASA's Dryden Flight Research Center, Edwards, Calif., in June 2001. His flying duties include a variety of research and support activities while piloting the F/A-18, DC-8, T-34C and King Air aircraft. He has more than 17 years and 3,800 hours of military and civilian flight experience in over 50 different aircraft types. Bomben came to NASA Dryden from a U.S. Navy assignment to the Personnel Exchange Program, Canada. He served as a test pilot in the Canadian Armed Forces located in Cold Lake, Alberta. He participated in numerous developmental programs to include CT-133 airborne ejection seat testing, F/A-18 weapons flutter testing and F/A-18 night vision goggles integration. Bomben performed U.S. Navy fleet service in 1995 as a strike-fighter department head. He completed two overseas deployments onboard the USS George Washington and USS Stennis. As a combat strike leader, he headed numerous multi-national missions over Iraq in support of Operation Southern Watch. Bomben graduated from the U.S. Naval Test Pilot School in 1992 and was subsequently assigned to the Naval Weapons Test Squadron at Pt. Mugu, Calif. During this tour he developed the F-14D bombsight and worked on various other F-14D and F/A-18 weapon systems developmental programs. Bomben is a 1985 graduate of Washington State University with a bachelor of science degree in electrical engineering. He graduated from naval flight training in 1987 and was recognized as a Commodore List graduate. His first assignment was to Naval Air Station Pensacola, Fla., where he was an instructor in the T-2B Buckeye. When selected to fly the F/A-18 in 1989, he joined a fleet squadron and deployed aboard the USS Forrestal. Bomben is married to the former Aissa Asuncion. They live in Lancaster, Calif., with their 3 children.

    10. senseless Repression of rough Is Required for R8 Photoreceptor Differentiation in the Developing Drosophila Eye

      PubMed Central

      Frankfort, Benjamin J.; Nolo, Riitta; Zhang, Zhihuan; Bellen, Hugo; Mardon, Graeme

      2011-01-01

      Summary An outstanding model to study how neurons differentiate from among a field of equipotent undifferentiated cells is the process of R8 photoreceptor differentiation during Drosophila eye development. We show that in senseless mutant tissue, R8 differentiation fails and the presumptive R8 cell adopts the R2/R5 fate. We identify senseless repression of rough in R8 as an essential mechanism of R8 cell fate determination and demonstrate that misexpression of senseless in non-R8 photoreceptors results in repression of rough and induction of the R8 fate. Surprisingly, there is no loss of ommatidial clusters in senseless mutant tissue and all outer photoreceptor subtypes can be recruited, suggesting that other photoreceptors can substitute for R8 to initiate recruitment and that R8-specific signaling is not required for outer photoreceptor subtype assignment. A genetic model of R8 differentiation is presented. PMID:11709152

    11. CALCIUM TRANSPORT PROCESSES OF LOBSTER HEPATOPANCREATIC MITOCHONDRIA. (R823068)

      EPA Science Inventory

      The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Concl...

    12. INFORMING THE POLICY PROCESS WITH COGNITIVE MAPPING. (R825791)

      EPA Science Inventory

      The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Concl...

    13. The Design Process for "PLATO[R] Math Problem Solving."

      ERIC Educational Resources Information Center

      Mulcahy, Robert

      2001-01-01

      PLATO Learning, Inc., a developer of computer-based instruction, recently released "Math Problem Solving." This product was designed to teach strategies for solving math problems, and consists of 19 problem-solving activities, ranging from basic math to algebra. Each activity includes tools to help find a solution and rule-based coaching to…

    14. R&D for graft adsorbents by radiation processing

      NASA Astrophysics Data System (ADS)

      Seko, Noriaki; Tamada, Masao

      Fibrous adsorbent for removal and recovery of metal ions have been synthesized by graft polymerization. In the grafting, the functional groups which have high selectivity against for target metal ions such as Fe, Sc, As, and U are introduced onto nonwoven fabric. When the monomer has a chelate group which makes selective coordination bond to specific these ions, it was directly grafted on the trunk polymer. In the case of precursor monomer having functional groups such as epoxy ring, the grafted trunk fabric is chemically modified. The resultant fibrous adsorbent leads the swift adsorption of metal ions. This property by using fibrous material can reduce the column size of adsorbent in the purification of waste water. The size of purification equipment becomes quite compact and that implies total volume of equipment can reduce. Instead of organic solvent, emulsion system which disperses monomer micelles in water with assistance of surfactant was found to accelerate the graft polymerization. This means the air pollution from organic solvent can be avoided by water system grafting. Furthermore, since the emulsion grafting was highly efficient, the required irradiation dose was considerably lower compared to general organic solvent system. As a result, the emulsion grafting has enormous potential for natural polymer to use as a trunk material for grafting. If a natural polymer such as cellulose can be used, the dependence on petroleum resources, the amount of industrial waste and the generation of carbon dioxide will be reduced to some extent.

    15. Upregulation of miR-150* and miR-630 Induces Apoptosis in Pancreatic Cancer Cells by Targeting IGF-1R

      PubMed Central

      Farhana, Lulu; Dawson, Marcia I.; Murshed, Farhan; Das, Jayanta K.; Rishi, Arun K.; Fontana, Joseph A.

      2013-01-01

      MicroRNAs have been implicated in many critical cellular processes including apoptosis. We have previously found that apoptosis in pancreatic cancer cells was induced by adamantyl retinoid-related (ARR) molecule 3-Cl-AHPC. Here we report that 3-Cl-AHPC-dependent apoptosis involves regulating a number of microRNAs including miR-150* and miR-630. 3-Cl-AHPC stimulated miR-150* expression and caused decreased expression of c-Myb and IGF-1R in the pancreatic cancer cells. 3-Cl-AHPC-mediated reduction of c-Myb resulted in diminished binding of c-Myb with IGF-1R and Bcl-2 promoters, thereby causing repression of their transcription and protein expression. Over-expression of miR-150* also resulted in diminished levels of c-Myb and Bcl-2 proteins. Furthermore, the addition of the miRNA inhibitor 2′-O-methylated miR-150 blocked 3-Cl-AHPC-mediated increase in miR-150* levels and abrogated loss of c-Myb protein. Knockdown of c-Myb in PANC-1 cells resulted in enhanced apoptosis both in the presence or absence of 3-Cl-AHPC confirming the anti-apoptotic property of c-Myb. Overexpression of miR-630 also induced apoptosis in the pancreatic cancer cells and inhibited target protein IGF-1R mRNA and protein expression. Together these results implicate key roles for miR-150* and miR-630 and their targeting of IGF-1R to promote apoptosis in pancreatic cancer cells. PMID:23675407

    16. Calcium binding decreases the stokes radius of calmodulin and mutants R74A, R90A, and R90G.

      PubMed Central

      Sorensen, B R; Shea, M A

      1996-01-01

      Calmodulin (CaM) is an intracellular cooperative calcium-binding protein essential for activating many diverse target proteins. Biophysical studies of the calcium-induced conformational changes of CaM disagree on the structure of the linker between domains and possible orientations of the domains. Molecular dynamics studies have predicted that Ca4(2+)CaM is in equilibrium between an extended and compact conformation and that Arg74 and Arg90 are critical to the compaction process. In this study gel permeation chromatography was used to resolve calcium-induced changes in the hydrated shape of CaM at pH 7.4 and 5.6. Results showed that mutation of Arg 74 to Ala increases the R(s) as predicted; however, the average separation of domains in Ca4(2+)-CaM was larger than predicted by molecular dynamics. Mutation of Arg90 to Ala or Gly affected the dimensions of apo-CaM more than those of Ca4(2+)-CaM. Calcium binding to CaM and mutants (R74A-CaM, R90A-CaM, and R90G-CaM) lowered the Stokes radius (R(s)). Differences between R(s) values reported here and Rg values determined by small-angle x-ray scattering studies illustrate the importance of using multiple techniques to explore the solution properties of a flexible protein such as CaM. Images FIGURE 2 SCHEME 1 FIGURE 3 PMID:8968610

    17. Solving Differential Equations in R

      NASA Astrophysics Data System (ADS)

      Soetaert, Karline; Meysman, Filip; Petzoldt, Thomas

      2010-09-01

      The open-source software R has become one of the most widely used systems for statistical data analysis and for making graphs, but it is also well suited for other disciplines in scientific computing. One of the fields where considerable progress has been made is the solution of differential equations. Here we first give an overview of the types of differential equations that R can solve, and then demonstrate how to use R for solving a 2-Dimensional partial differential equation.

    18. Evolution of the miR-290–295/miR-371–373 Cluster Family Seed Repertoire

      PubMed Central

      Wu, Shuang; Aksoy, Munevver; Shi, Jianting; Houbaviy, Hristo Botev

      2014-01-01

      Expression of the mouse miR-290–295 cluster and its miR-371–373 homolog in human is restricted to early embryos, primordial germ cells, the germ line stem cell compartment of the adult testis and to stem cell lines derived from the early embryonic lineages. Sequencing data suggest considerable seed diversification between the seven homologous pre-miRNAs of miR-290–295 but it is not clear if all of the implied miR-290–295 seeds are also conserved in the human miR-371–373 cluster, which consists of only three homologous pre-miRNAs. By employing miRNA target reporters we show that most, if not all, seeds in miR-290–295 are represented in miR-371–373. In the mouse, pre-miR-290, pre-miR-292 and pre-miR-293 express subsets of the miRNA isoforms processed from the single human pre-miR-371. Comparison of the possible miR-290–295/miR-371–373 seed repertoires in placental mammals suggests a model for the evolution of this miRNA cluster family, which would be otherwise difficult to deduce based solely on pre-miRNA sequence comparisons. The conservation of co-expressed seeds that is characteristic of miR-290–295/miR-371–373 should be taken into account in models of the corresponding miRNA-target interaction networks. PMID:25268927

    19. miR-27a and miR-27a* contribute to metastatic properties of osteosarcoma cells

      PubMed Central

      Maximov, Vadim; Galasso, Marco; Khawaled, Saleh; Abou-Sharieha, Samah; Volinia, Stefano; Jones, Kevin B.; Croce, Carlo M.; Aqeilan, Rami I.

      2015-01-01

      Osteosarcoma (OS) is the most common primary malignant bone tumor in adolescents and young adults. The essential mechanisms underlying osteosarcomagenesis and progression continue to be obscure. MicroRNAs (miRNAs) have far-reaching effects on the cellular biology of development and cancer. We recently reported that unique miRNA signatures associate with the pathogenesis and progression of OS. Of particular interest, we found that higher expression of miR-27a is associated with clinical metastatic disease. We report here that overexpression of miR-27a/miR-27a*, a microRNA pair derived from a single precursor, promotes pulmonary OS metastases formation. By contrast, sequestering miR-27a/miR-27a* by sponge technology suppressed OS cells invasion and metastases formation. miR-27a/miR-27a* directly repressed CBFA2T3 expression among other target genes. We demonstrated that CBFA2T3 is downregulated in majority of OS samples and its over expression significantly attenuated OS metastatic process mediated by miR-27a/miR-27a* underscoring CBFA2T3 functions as a tumor suppressor in OS. These findings establish that miR-27a/miR-27a* pair plays a significant role in OS metastasis and proposes it as a potential diagnostic and therapeutic target in managing OS metastases. PMID:25749032

    20. Adsorption of poly(rA) on the carbon nanotube surface and its hybridization with poly(rU).

      PubMed

      Karachevtsev, Victor A; Gladchenko, Galyna O; Karachevtsev, Maksym V; Valeev, Vladimir A; Leontiev, Victor S; Lytvyn, Oksana S

      2008-10-01

      Adsorption of poly(rA) on a single-walled carbon nanotube surface in aqueous suspension and the subsequent hybridization of this polymer with free poly(rU) is studied. A comparison of the temperature dependence of the absorbance of free poly(rA) and poly(rA) adsorbed on the nanotube surface [poly(rA)(NT)] at nu(max)= 38,500 cm(-1) shows that the thermostability of the adsorbed polymer is higher. Molecular dynamics simulations demonstrate that more than half of the adenines are not stacked on the tube surface and some of them undergo self-stacking. After addition of a complementary poly(rU) to the poly(rA)(NT) suspension, a double-stranded polymer is formed as confirmed by the characteristic S-like form of its melting curve. However, the melting temperature of this polymer is lower than that of the free poly(rA)poly(rU) duplex. This result indicates that poly(rU) hybridization with poly(rA)(NT) occurs with defects along the whole length of the polymer because of pi-pi stacking between nitrogen bases and the nanotube surface, which hinders the usual hybridization process. Computer modeling demonstrates different possible structures of hybridized polymers on the nanotube surface. PMID:18780410

    1. "catR": An R Package for Computerized Adaptive Testing

      ERIC Educational Resources Information Center

      Magis, David; Raiche, Gilles

      2011-01-01

      Computerized adaptive testing (CAT) is an active current research field in psychometrics and educational measurement. However, there is very little software available to handle such adaptive tasks. The R package "catR" was developed to perform adaptive testing with as much flexibility as possible, in an attempt to provide a developmental and…

    2. "catR": An R Package for Computerized Adaptive Testing

      ERIC Educational Resources Information Center

      Magis, David; Raiche, Gilles

      2011-01-01

      Computerized adaptive testing (CAT) is an active current research field in psychometrics and educational measurement. However, there is very little software available to handle such adaptive tasks. The R package "catR" was developed to perform adaptive testing with as much flexibility as possible, in an attempt to provide a developmental and

    3. Ceramic fabrication R D

      SciTech Connect

      Not Available

      1990-01-01

      This project is separated into three tasks. The first task is a design and modeling effort to be carried out by MSE, Inc. The purpose of this task is to develop and analyze designs for various cohesive ceramic fabrication (CCF) components, including an MHD electrode for strategic defense initiative (SDI) applications and a high stress, low cost, reinforced ceramic component for armor applications. The MHD electrode design is substantially completed. A layered structure composed of molybdenum disilicide graded with quartz glass has been designed and analyzed using finite element methods. The design demonstrates the fabrication capabilities of the CCF process. The high stress, armor application component will be silicon carbide reinforced alumina in thick plates. 2 refs., 4 figs., 1 tab.

    4. Microbial Extracellular Enzyme Activity and Community Assembly Processes Post Fire Disturbance Amanda Labrado, University of Texas at El Paso; Emily B. Graham, University of Colorado Boulder; Joseph E. Knelman, University of Colorado Boulder; Scott Ferrenberg, University of Colorado Boulder; Diana R. Nemergut, University of Colorado Boulder

      NASA Astrophysics Data System (ADS)

      Labrdo, A.; Knelman, J. E.; Graham, E. B.; Ferrenberg, S.; Nemergut, D. R.

      2013-12-01

      Microbes control major biogeochemical cycles and can directly impact the carbon, nitrogen, and phosphorus pools and fluxes of soils. However, many questions remain regarding when and where data on microbial community structure are necessary to accurately predict biogeochemical processes. In particular, it is unknown how shifts in microbial assembly processes may relate to changes in the relationship between community structure and ecosystem function. Here, we examine soil microbial community assembly processes and extracellular enzyme activity (EEA) at 4-weeks and 16-weeks after the Fourmile Canyon Fire in Boulder, CO in order to determine the effects of disturbance on community assembly and EEA. Microbial community structure was determined from 16S rRNA gene pyrosequencing, edaphic properties were determined using standard biogeochemical assays, and extracellular enzyme activity for β-1, 4-glucosidase (BG) and β-1, 4-N-acetylglucosaminidase (NAG) enzymes were determined using fluorimetric assays. Stepwise linear regressions were used to determine the effects of microbial community structure and edaphic factors on EEA. We determined that in 4-week post fire samples EEA was only correlated with microbial predictors. However, we observed a shift with 16-week samples in which EEA was significantly related to edaphic predictors. Null derivation analysis of community assembly revealed that communities in the 4-week samples were more neutrally assembled than communities in the 16-week samples. Together, these results support a conceptual model in which the relationship between edaphic factors and ecosystem processes is somewhat decoupled in more neutrally assembled communities, and data on microbial community structure is important to most accurately predict function.

    5. Rosen's (M,R) system in Unified Modelling Language.

      PubMed

      Zhang, Ling; Williams, Richard A; Gatherer, Derek

      2016-01-01

      Robert Rosen's (M,R) system is an abstract biological network architecture that is allegedly non-computable on a Turing machine. If (M,R) is truly non-computable, there are serious implications for the modelling of large biological networks in computer software. A body of work has now accumulated addressing Rosen's claim concerning (M,R) by attempting to instantiate it in various software systems. However, a conclusive refutation has remained elusive, principally since none of the attempts to date have unambiguously avoided the critique that they have altered the properties of (M,R) in the coding process, producing merely approximate simulations of (M,R) rather than true computational models. In this paper, we use the Unified Modelling Language (UML), a diagrammatic notation standard, to express (M,R) as a system of objects having attributes, functions and relations. We believe that this instantiates (M,R) in such a way than none of the original properties of the system are corrupted in the process. Crucially, we demonstrate that (M,R) as classically represented in the relational biology literature is implicitly a UML communication diagram. Furthermore, since UML is formally compatible with object-oriented computing languages, instantiation of (M,R) in UML strongly implies its computability in object-oriented coding languages. PMID:26723228

    6. Jet activity in the symbiotic variable R Aquarii

      NASA Technical Reports Server (NTRS)

      Michalitsianos, A. G.; Hollis, J. M.; Kafatos, M.

      1986-01-01

      Low-resolution ultraviolet spectra of the R Aquarii jet have been obtained with the International Ultraviolet Explorer (IUE). The most recent IUE observations indicate the ionization state of the jet is increasing. Subarcsecond, Very Large Array observations of R Aquarii have resolved the radio-continuum structure into discrete parcels of emission that are extended and nearly collinear. R Aquarii provides evidence that indicates stellar jet activity is not unique to objects associated with high-energy emission processes alone. Rather, the nature of the aligned radio-optical features that comprise the R Aquarii jet indicate that directional mass expulsion, in the form of discrete-collimated ejecta, probably reflect a general, underlying, physical process associated with a wide variety of peculiar stellar objects. As such, the R Aquarii jet constitutes a prototype for jet activity in composite or peculiar emission stars.

    7. Oklahoma NASA EPSCoR

      NASA Technical Reports Server (NTRS)

      Snowden, Victoria Duca

      2002-01-01

      The mission of Oklahoma EPSCoR is to make Oklahoma researchers more successful in competing for research funding. Specific goals, objectives, and strategies were developed for each federal EPSCoR program, based on federal and state needs. A theme of stimulating collaboration among campuses and building on common research strengths is a strong component of the Oklahoma EPSCoR strategic plan. It extends also to our relationships with the federal agencies, and wherever possible, Oklahoma EPSCoR projects are developed collaboratively with federal research laboratories and program offices. Overall, Oklahoma EPSCoR seeks to capitalize on unique research capabilities and opportunities. The NASA EPSCoR Program in Oklahoma was developed through this grant as a joint effort between Oklahoma EPSCoR and the NASA Oklahoma Space Grant Consortium (OSGC). The major goal of the Oklahoma NASA EPSCoR Plan established in 1996 is to develop an academic research enterprise directed towards a long-term, self-sustaining, nationally competitive capability in areas of mutual self-interest to NASA and Oklahoma. Our final technical summary pie chart demonstrates the strong successes we have achieved during this period as a result of the award.

    8. MiR-9 and miR-21 as prognostic biomarkers for recurrence in papillary thyroid cancer.

      PubMed

      Sondermann, Adriana; Andreghetto, Flavia Maziero; Moulatlet, Ana Carolina Bernardini; da Silva Victor, Elivane; de Castro, Marilia Germanos; Nunes, Fábio Daumas; Brandão, Lenine Garcia; Severino, Patricia

      2015-08-01

      Despite low mortality rates, nodal recurrence in papillary thyroid carcinoma occurs in up to 20 % of patients. Emerging evidences indicate that dysregulated microRNAs are implicated in the process of metastasis. In the present study, we investigated whether miR-9, miR-10b, miR-21 and miR-146b levels are predictive of papillary thyroid carcinoma recurrence. Using macro-dissection followed by quantitative real-time PCR, we measured miR-9, miR-10b, miR-21 and miR-146b expression levels in formalin-fixed, paraffin-embedded samples of 66 patients with papillary thyroid carcinoma categorized into two groups: the recurrent group (n = 19) and the non-recurrent group (n = 47). All patients underwent total thyroidectomy and were followed for at least 120 months after surgery to be considered recurrence-free. Univariate and multivariate analysis were performed using the Cox proportional hazard model in order to identify associations between multiple clinical variables and microRNA expression levels and papillary thyroid carcinoma recurrence. MiR-9 and miR-21 expression levels were found to be significant prognostic factors for recurrence in patients with papillary thyroid carcinoma (HR = 1.48; 95 % CI 1.24-1.77, p < 0.001; and HR = 1.52; 95 % CI 1.18-1.94, p = 0.001; respectively). Multivariate analysis involving the expression level of miR-9 and miR-21 and various clinical parameters identified the expression of these microRNAs as independent prognostic factors for papillary thyroid cancer patients. In conclusion, our results support the potential clinical value of miR-9 and miR-21 as prognostic biomarkers for recurrence in papillary thyroid carcinoma. PMID:26007293

    9. R/V Maurice Ewing retires

      NASA Astrophysics Data System (ADS)

      Diebold, John

      2005-07-01

      The R/V Maurice Ewing came into port for the last time on 10 March 2005, tying up at Quonset Point, R.I., astern of the ship slated to be her replacement (Figure 1). M/V Western Legend (Figure 1, left) will, during fall and winter of 2005-2006, be converted as R/V Marcus G. Langseth, and will replace the Maurice Ewing (Figure 1, right) as the primary seismic research vessel within the U.S. academic research vessel fleet.During its distinguished 15-year career, Ewing's operations added fundamentally to the knowledge and understanding of solid Earth dynamics and structure. Ewing began life as the M/V Bernier, and performed seismic offshore exploration for Petro Canada. In an innovative process, which included initialization provided by Columbia University, the U.S. National Science Foundation (NSF) acquired Bernier in 1989, and the ship's title passed to NSF in 1990. Bernier was converted into R/V Ewing for a total expenditure (approximately $12 million) far below the cost of building and outfitting a new seismic research ship.

    10. System performance comparison of R-507 with R-502

      SciTech Connect

      Linton, J.W.; Snelson, W.K.; Triebe, A.R.; Hearty, P.F.

      1995-12-31

      R-507 is an azeotrope of HFC-125/HFC-143a (50%/50%) and is a long-term, zero ozone depletion potential (ODP) replacement for CFC-containing low-temperature refrigerant R-502. A series of system performance tests has been completed comparing R-507 with R-502. The tests were carried out under controlled conditions in a well-instrumented alternative refrigerants test facility, using an open-drive reciprocating compressor and counterflow tube-in-tube heat exchangers. Measurements were conducted at two different condensing temperatures; 54.4 C (130.0 F) and 43.3 C (110.0 F). The refrigerant evaporating temperature was varied over a range of {minus}30.0 C to {minus}15.0 C ({minus}22.0 F to 5.0 F). The degree of liquid subcooling at the condenser outlet was varied between 6.0 C and 18.0 C (10.8 F and 32.4 F). Test data were used to compare important compressor performance characteristics including shaft power, pressure ratio, and compressor discharge temperature. System performance characteristics were also measured, including evaporator capacity, refrigerant mass flow, and cooling coefficient of performance (COP). The effect of additional liquid subcooling on the evaporator capacity and COP was also evaluated. The relative evaporator capacity of R-507 compared to R-502 was found to range from 0.95 to 1.05, depending on the operating conditions and the amount of liquid subcooling present. For all the conditions tested, R-507 was less energy efficient than R-502. The relative COP of R-507 ranged from 0.87 to 0.97.

    11. 75 FR 71532 - Airworthiness Directives; Robinson Helicopter Company (Robinson) Model R22, R22 Alpha, R22 Beta...

      Federal Register 2010, 2011, 2012, 2013, 2014

      2010-11-24

      ..., 2010. That NPRM was published in the Federal Register on July 15, 2010 (75 FR 41104). That action... rule'' under the DOT Regulatory Policies and Procedures (44 FR 11034, February 26, 1979); and 3. Will... Company (Robinson) Model R22, R22 Alpha, R22 Beta, and R22 Mariner Helicopters, and Model R44, and R44...

    12. GOES-R product and algorithm development

      NASA Astrophysics Data System (ADS)

      Powell, Alfred M., Jr.; Goldberg, Mitch; Colton, Marie

      2005-08-01

      With the launch of GOES-R, the next generation of geostationary environmental monitoring satellites will have gone from the drawing board to on-orbit operations. New products will flow through a processing system that took years to develop and perfect. Around 2012, users will finally get their first taste of the latest remote environmental monitoring products from geostationary orbit. To achieve this capability and make the new environmental monitoring system a success, algorithmic products will have to be developed, tested and then transitioned into an operational environment. This article addresses planned changes in the algorithm development process for GOES-R that will lead to a successful implementation of this new satellite and processing system. Notional concepts will be used to describe potential GOESR algorithm development processes, their benefits and the efficiencies to be gained from those changes. While the concepts described indicate a strategy, the final science into operations concepts will continue to evolve until the contract for building the system is awarded to a commercial vendor.

    13. Implementing Spatial Segregation Measures in R

      PubMed Central

      Hong, Seong-Yun; O'Sullivan, David; Sadahiro, Yukio

      2014-01-01

      Reliable and accurate estimation of residential segregation between population groups is important for understanding the extent of social cohesion and integration in our society. Although there have been considerable methodological advances in the measurement of segregation over the last several decades, the recently developed measures have not been widely used in the literature, in part due to their complex calculation. To address this problem, we have implemented several newly proposed segregation indices in R, an open source software environment for statistical computing and graphics, as a package called seg. Although there are already a few standalone applications and add-on packages that provide access to similar methods, our implementation has a number of advantages over the existing tools. First, our implementation is flexible in the sense that it provides detailed control over the calculation process with a wide range of input parameters. Most of the parameters have carefully chosen defaults, which perform acceptably in many situations, so less experienced users can also use the implemented functions without too much difficulty. Second, there is no need to export results to other software programs for further analysis. We provide coercion methods that enable the transformation of our output classes into general R classes, so the user can use thousands of standard and modern statistical techniques, which are already available in R, for the post-processing of the results. Third, our implementation does not require commercial software to operate, so it is accessible to a wider group of people. PMID:25415326

    14. Genome-Wide Identification of R2R3-MYB Genes and Expression Analyses During Abiotic Stress in Gossypium raimondii.

      PubMed

      He, Qiuling; Jones, Don C; Li, Wei; Xie, Fuliang; Ma, Jun; Sun, Runrun; Wang, Qinglian; Zhu, Shuijin; Zhang, Baohong

      2016-01-01

      The R2R3-MYB is one of the largest families of transcription factors, which have been implicated in multiple biological processes. There is great diversity in the number of R2R3-MYB genes in different plants. However, there is no report on genome-wide characterization of this gene family in cotton. In the present study, a total of 205 putative R2R3-MYB genes were identified in cotton D genome (Gossypium raimondii), that are much larger than that found in other cash crops with fully sequenced genomes. These GrMYBs were classified into 13 groups with the R2R3-MYB genes from Arabidopsis and rice. The amino acid motifs and phylogenetic tree were predicted and analyzed. The sequences of GrMYBs were distributed across 13 chromosomes at various densities. The results showed that the expansion of the G. Raimondii R2R3-MYB family was mainly attributable to whole genome duplication and segmental duplication. Moreover, the expression pattern of 52 selected GrMYBs and 46 GaMYBs were tested in roots and leaves under different abiotic stress conditions. The results revealed that the MYB genes in cotton were differentially expressed under salt and drought stress treatment. Our results will be useful for determining the precise role of the MYB genes during stress responses with crop improvement. PMID:27009386

    15. Genome-Wide Identification of R2R3-MYB Genes and Expression Analyses During Abiotic Stress in Gossypium raimondii

      PubMed Central

      He, Qiuling; Jones, Don C.; Li, Wei; Xie, Fuliang; Ma, Jun; Sun, Runrun; Wang, Qinglian; Zhu, Shuijin; Zhang, Baohong

      2016-01-01

      The R2R3-MYB is one of the largest families of transcription factors, which have been implicated in multiple biological processes. There is great diversity in the number of R2R3-MYB genes in different plants. However, there is no report on genome-wide characterization of this gene family in cotton. In the present study, a total of 205 putative R2R3-MYB genes were identified in cotton D genome (Gossypium raimondii), that are much larger than that found in other cash crops with fully sequenced genomes. These GrMYBs were classified into 13 groups with the R2R3-MYB genes from Arabidopsis and rice. The amino acid motifs and phylogenetic tree were predicted and analyzed. The sequences of GrMYBs were distributed across 13 chromosomes at various densities. The results showed that the expansion of the G. Raimondii R2R3-MYB family was mainly attributable to whole genome duplication and segmental duplication. Moreover, the expression pattern of 52 selected GrMYBs and 46 GaMYBs were tested in roots and leaves under different abiotic stress conditions. The results revealed that the MYB genes in cotton were differentially expressed under salt and drought stress treatment. Our results will be useful for determining the precise role of the MYB genes during stress responses with crop improvement. PMID:27009386

    16. Specificity and Polymorphism of the PlcR-PapR Quorum-Sensing System in the Bacillus cereus Group

      PubMed Central

      Slamti, Leyla; Lereclus, Didier

      2005-01-01

      The expression of extracellular virulence factors in various species of the Bacillus cereus group is controlled by the plcR and papR genes, which encode a transcriptional regulator and a cell-cell signaling peptide, respectively. A processed form of PapR, presumably a pentapeptide, specifically interacts with PlcR to facilitate its binding to its DNA targets. This activating mechanism is strain specific, with this specificity being determined by the first residue of the pentapeptide. We carried out in vivo complementation assays and compared the PlcR-PapR sequences of 29 strains from the B. cereus group. Our findings suggested that the fifth amino acid of the pentapeptide is also involved in the specificity of activation. We identified four classes of PlcR-PapR pairs, defining four distinct pherotypes in the B. cereus group. We used these findings to look at the evolution of the PlcR-PapR quorum-sensing system with regard to the phylogeny of the species forming the B. cereus group. PMID:15659693

    17. Resistance to EGF-R (erbB-1) and VEGF-R modulating agents.

      PubMed

      Dempke, Wolfram C M; Heinemann, Volker

      2009-05-01

      In an effort to improve the survival of cancer patients, new therapeutic approaches focusing on the molecular mechanisms that mediate tumour cell growth or survival have gained much attention. In particular, EGF-R and VEGF/VEGF-R have been extensively investigated as targets for anti-neoplastic therapy. Agents that selectively target EGF-R, erbB-2, VEGF-R-2 or VEGF have shown promising activity in clinical trials, and several are now approved for use in selected cancer indications. However, all patients ultimately develop resistance to these drugs. Thus, there is a great need to understand how patients become resistant to effective therapies for these cancers since this approach may lead to improvements in therapies that target EGF-R and VEGF/VEGF-R. Pre-clinical studies have begun to shed light on the mechanisms of resistance to anti-angiogenetic drugs and to date four mechanisms of resistance have been identified (1) upregulation of bFGF, (2) overexpression of MMP-9, (3) increased levels of SDF-1alpha and (4) HIF-1alpha-induced recruitment of bone marrow-derived CD45+ myeloid cells. In addition, the molecular mechanisms of resistance to EGF-R modulating agents can be attributed to several general processes: (1) activation of alternative tyrosine kinase inhibitors that bypass the EGF-R pathway (e.g. c-MET and IGF-1R), (2) increased angiogenesis, (3) constitutive activation of downstream mediators (e.g. PTEN and K-ras) and (4) the existence of specific EGF-R mutations. K-ras mutations have been significantly associated with a lack of response to EGF-R tyrosine kinase inhibitors in patients with NSCLC and with a lack of response to cetuximab or to panitumumab in patients with advanced colorectal cancer. The identification of these resistance mechanisms has led to clinical trials using newly designed targeted therapies that can overcome resistance and have shown promise in laboratory studies. Ongoing research efforts will likely continue to identify additional resistance mechanisms, and these findings will hopefully translate into effective therapies for different cancers. PMID:19124237

    18. PaR-PaR Laboratory Automation Platform

      SciTech Connect

      Linshiz, G; Stawski, N; Poust, S; Bi, CH; Keasling, JD; Hilson, NJ

      2013-05-01

      Labor-intensive multistep biological tasks, such as the construction and cloning of DNA molecules, are prime candidates for laboratory automation. Flexible and biology-friendly operation of robotic equipment is key to its successful integration in biological laboratories, and the efforts required to operate a robot must be much smaller than the alternative manual lab work. To achieve these goals, a simple high-level biology-friendly robot programming language is needed. We have developed and experimentally validated such a language: Programming a Robot (PaR-PaR). The syntax and compiler for the language are based on computer science principles and a deep understanding of biological workflows. PaR-PaR allows researchers to use liquid-handling robots effectively, enabling experiments that would not have been considered previously. After minimal training, a biologist can independently write complicated protocols for a robot within an hour. Adoption of PaR-PaR as a standard cross-platform language would enable hand-written or software-generated robotic protocols to be shared across laboratories.

    19. R&D in the Federal Budget: FY 1979, R&D, Industry, and the Economy. Research & Development, AAAS Report III.

      ERIC Educational Resources Information Center

      Shapley, Willis H.; Phillips, Don I.

      The federal government's budgeting process for allocating resources to research and development (R&D) is described. The report includes: (1) a review of the FY 1979 R&D budget; (2) a statistical overview of the budget and a critique of the administration's policies on R&D; (3) a general picture of R&D in industry; and (4) a discussion of some of

    20. Optimization of R-(+)-alpha-terpineol production by the biotransformation of R-(+)-limonene.

      PubMed

      Bicas, Juliano Lemos; Barros, Francisco Fábio Cavalcante; Wagner, Roger; Godoy, Helena Teixeira; Pastore, Gláucia Maria

      2008-09-01

      R-(+)-limonene is an abundant and non-expensive by-product of the citrus industry and is, therefore, a suitable starting material for the production of natural flavor and fragrance compounds. The biotransformation of R-(+)-limonene to R-(+)-alpha-terpineol by Fusarium oxysporum 152b has already been reported, although the influence of the main process parameters on the production has not yet been evaluated. In this paper, a Plackett-Burman screening design was used to define the effects of the medium composition (glucose, peptone, yeast extract, malt extract and pH), the presence of a co-substrate (biosurfactant), the cultivation conditions (temperature, agitation), the substrate concentration and the inoculum/culture medium ratio on the absolute amount of R-(+)-alpha-terpineol resulting from this biotransformation. The process conditions were further optimized applying response surface methodology (RSM). The volatiles were extracted using a SPME device and were subsequently quantified by GC-FID and identified by GC-MS. The best results were obtained using 0.5% (v/m) R-(+)-limonene in pure distilled water as the culture medium with an inoculum/culture medium ratio of 0.25 (m/m) and 72 h cultivation at 26 degrees C/240 rpm. Under these conditions the concentration of R-(+)-alpha-terpineol in the culture medium reached 2.4 g L(-1), a production almost six times greater than in earlier trials. The presence of a biosurfactant (0-500 mg L(-1)) did not significantly increase the yield. PMID:18560915

    1. DEMONSTRATION BULLETIN: EX-SITU ANAEROBIC BIOREMEDIATION TECHNOLOGY - TNT - J.R. SIMPLOT COMPANY

      EPA Science Inventory

      The J. R. Simplot Ex-Situ Anaerobic Bioremediation System, also known as the J.R. Simplot Anaerobic Biological Remediaton Process (the SABRE™ Process), is a technology designed to destroy nitroaromatic and energetic compounds. The process does not evolve any known toxic intermedi...

    2. DEMONSTRATION BULLETIN: EX-SITU ANAEROBIC BIOREMEDIATION TECHNOLOGY - TNT - J.R. SIMPLOT COMPANY

      EPA Science Inventory

      The J. R. Simplot Ex-Situ Anaerobic Bioremediation System, also known as the J.R. Simplot Anaerobic Biological Remediaton Process (the SABRE Process), is a technology designed to destroy nitroaromatic and energetic compounds. The process does not evolve any known toxic intermedi...

    3. Solving Differential Equations in R

      EPA Science Inventory

      Although R is still predominantly applied for statistical analysis and graphical representation, it is rapidly becoming more suitable for mathematical computing. One of the fields where considerable progress has been made recently is the solution of differential equations. Here w...

    4. The Evaluation of Technology R&D: A Continuing Dilemma.

      ERIC Educational Resources Information Center

      de Leon, Peter

      The development of advanced technologies needs to be assessed as part of an on-going process. A technology evaluation agenda is presented. Research and development (R and D) is a sequential, changing process. The formulation of standards and criteria is a function of the stage of development and type of technology. The criteria should be…

    5. R-HyMOD: an R-package for the hydrological model HyMOD

      NASA Astrophysics Data System (ADS)

      Baratti, Emanuele; Montanari, Alberto

      2015-04-01

      A software code for the implementation of the HyMOD hydrological model [1] is presented. HyMOD is a conceptual lumped rainfall-runoff model that is based on the probability-distributed soil storage capacity principle introduced by R. J. Moore 1985 [2]. The general idea behind this model is to describe the spatial variability of some process parameters as, for instance, the soil structure or the water storage capacities, through probability distribution functions. In HyMOD, the rainfall-runoff process is represented through a nonlinear tank connected with three identical linear tanks in parallel representing the surface flow and a slow-flow tank representing groundwater flow. The model requires the optimization of five parameters: Cmax (the maximum storage capacity within the watershed), β (the degree of spatial variability of the soil moisture capacity within the watershed), α (a factor for partitioning the flow between two series of tanks) and the two residence time parameters of quick-flow and slow-flow tanks, kquick and kslow respectively. Given its relatively simplicity but robustness, the model is widely used in the literature. The input data consist of precipitation and potential evapotranspiration at the given time scale. The R-HyMOD package is composed by a 'canonical' R-function of HyMOD and a fast FORTRAN implementation. The first one can be easily modified and can be used, for instance, for educational purposes; the second part combines the R user friendly interface with a fast processing unit. [1] Boyle D.P. (2000), Multicriteria calibration of hydrological models, Ph.D. dissertation, Dep. of Hydrol. and Water Resour., Univ of Arizona, Tucson. [2] Moore, R.J., (1985), The probability-distributed principle and runoff production at point and basin scale, Hydrol. Sci. J., 30(2), 273-297.

    6. Publication process

      NASA Astrophysics Data System (ADS)

      Russell, C. T.; Reiff, P. H.

      Those who have contributed to the research literature are quite familiar with the workings of the publication process, even though they may not have seen it explicitly set down as is done in the accompanying flow chart. However, for the benefit of students, who are thought to read Eos, if only for the classified ads, and editors, who may have lost sight of the forest for the trees, we have requested that AGU publish this diagram. T h e flow chart is self-explanatory. We note that ?tA,?tE, and ?tR are time delays introduced by the author, the editor, and the referee. Since the editor gets to handle the paper twice each iteration (the number of which is counted by the index, I) he is responsible for a time delay of 2 ?tE. The number NJ is journal dependent, ranging from 0 for some conference proceedings and forprofit journals, to 2 (or greater) for some AGU journals. (For example, this is our third submittal of this forum.) We would particularly like to thank G.C. Reid and S. Solomon and the many others who have had a hand in codifying this flow chart over the years and Eos editor, L.J. Lanzerotti, for his assistance in the further refinement of various details.

    7. Portrait of Robert R. Gilruth

      NASA Technical Reports Server (NTRS)

      1946-01-01

      Robert R. Gilruth (Portrait) an engineering observer in the late 1930s, had a keen appreciation for the pilot's side of the man-machine relationship. He learned a great deal from Melvin N. Gough, Langley's chief test pilot, who took great pains to educate Gilruth about airplane handling characteristics. Photograph published in Engineer in Charge: A History of the Langley Aeronautical Laboratory, 1917-1958 by James R. Hansen. Page 265.

    8. R-symmetric gauge mediation

      NASA Astrophysics Data System (ADS)

      De Lope Amigo, Santiago; Blechman, Andrew E.; Fox, Patrick J.; Poppitz, Erich

      2009-01-01

      We present a version of Gauge Mediated Supersymmetry Breaking which preserves an R-symmetrythe gauginos are Dirac particles, the A-terms are zero, and there are four Higgs doublets. This offers an alternative way for gauginos to acquire mass in the supersymmetry-breaking models of Intriligator, Seiberg, and Shih. We investigate the possibility of using R-symmetric gauge mediation to realize the spectrum and large sfermion mixing of the model of Kribs, Poppitz, and Weiner.

    9. GOES-R: Satellite Insight

      NASA Technical Reports Server (NTRS)

      Fitzpatrick, Austin J.; Leon, Nancy J.; Novati, Alexander; Lincoln, Laura K.; Fisher, Diane K.

      2012-01-01

      GOES-R: Satellite Insight seeks to bring awareness of the GOES-R (Geostationary Operational Environmental Satellite -- R Series) satellite currently in development to an audience of all ages on the emerging medium of mobile games. The iPhone app (Satellite Insight) was created for the GOES-R Program. The app describes in simple terms the types of data products that can be produced from GOES-R measurements. The game is easy to learn, yet challenging for all audiences. It includes educational content and a path to further information about GOESR, its technology, and the benefits of the data it collects. The game features action-puzzle game play in which the player must prevent an overflow of data by matching falling blocks that represent different types of GOES-R data. The game adds more different types of data blocks over time, as long as the player can prevent a data overflow condition. Points are awarded for matches, and players can compete with themselves to beat their highest score.

    10. Breaking bad: R-loops and genome integrity.

      PubMed

      Sollier, Julie; Cimprich, Karlene A

      2015-09-01

      R-loops, nucleic acid structures consisting of an RNA-DNA hybrid and displaced single-stranded (ss) DNA, are ubiquitous in organisms from bacteria to mammals. First described in bacteria where they initiate DNA replication, it now appears that R-loops regulate diverse cellular processes such as gene expression, immunoglobulin (Ig) class switching, and DNA repair. Changes in R-loop regulation induce DNA damage and genome instability, and recently it was shown that R-loops are associated with neurodegenerative disorders. We discuss recent developments in the field; in particular, the regulation and effects of R-loops in cells, their effect on genomic and epigenomic stability, and their potential contribution to the origin of diseases including cancer and neurodegenerative disorders. PMID:26045257

    11. DOE R and D data tracking base

      SciTech Connect

      Horpedahl, L.; Brooks, M.

      2000-12-01

      This document consists of DOE R and D tracking information for the following topics: Stockpile Readiness Program; Stockpile Reduction Program; Enduring Stockpile Program; Future Stockpile Program; Archiving; Nuclear Component Assessment; Advanced Application; Validation and Verification; Distance and Distributed Computing; DOD Munitions; Performance Assessment; Physics; Los Alamos Meson Physics Facility/Los Alamos Neutron Science Center; Advanced Hydrodynamic Radiography; Systems Engineering; Advanced Manufacturing; Chemistry and Materials; High Explosives; Special Nuclear Mateirals; Tritium; Collaboration with ASCI; Numeric Environment for Weapons Simulation; Target Physics; Theory and Modeling; Target Development; Fabrication and Handling; Other ICF Activities; Development of Predictive Capabilities--Nuclear; Development of Diagnostic Tools--Nuclear; Process Development; and IPPD/Agile Manufacturing.

    12. Issues on Selecting National R&D Project

      NASA Astrophysics Data System (ADS)

      Lee, Joon; Kook, Youn-Gyou; Kim, Jae-Soo; Choi, Ki-Seock

      Because of the difficulties on selecting National R&D projects, it is expected that the errors of decision making can be reduced if the information on project (i.e. project duration, people, budget etc.), and its evaluation result is properly provided to stakeholders as a reference. In reality, however, the result of project evaluation is rarely utilized in its own purpose. One reason is that the information on evaluation result and budget is not shared amongst stakeholders at the right time. The other is that the interconnection between systems to support the R&D evaluation and budget information is not realized yet for further utilization. Therefore, this paper is focused on the improvement of decision process that reviews and selects the R&D project to provide relevant information through the data mapping approaches from different system domain and to suggest the enhanced process for the seamless interconnection between National R&D performance evaluation and budget information.

    13. Process for functionalizing alkanes

      DOEpatents

      Bergman, Robert G.; Janowicz, Andrew H.; Periana, Roy A.

      1988-01-01

      Process for functionalizing saturated hydrocarbons comprising: (a) reacting said saturated hydrocarbons of the formula: R.sub.1 H wherein H represents a hydrogen atom; and R.sub.1 represents a saturated hydrocarbon radical, with a metal complex of the formula: CpRh[P(R.sub.2).sub.3 ]H.sub.2 wherein Cp represents a cyclopentadienyl or alkylcyclopentadienyl radical; Rh represents a rhodium atom; P represents a phosphorus atom; R.sub.2 represents a hydrocarbon radical; H represents a hydrogen atom, in the presence of ultraviolet radiation to form a hydridoalkyl complex of the formula: CpRh[P(R.sub.2).sub.3 ](R.sub.1)H (b) reacting said hydridoalkyl complex with an organic halogenating agent such as a tetrahalomethane or a haloform of the formulas: CX'X''X'''X'''' or CHX'X''X''' wherein X', X'', X'", X"" represent halogens selected from bromine, iodine or chlorine atom, at a temperature in the range of about -60.degree. to -17.degree. C. to form the corresponding haloalkyl complex of step (a) having the formula: CpRhPMe.sub.3 RX; and, (c) reacting said haloalkyl complex formed in (b) with halogen (X.sub.2) at a temperature in the range of about -60.degree. to 25.degree. C. (i.e., ambient) to form a functional haloalkyl compound.

    14. Surface configuration in R + μ4/R gravity

      NASA Astrophysics Data System (ADS)

      Fathi, Mohsen; Mohseni, Morteza

      2015-09-01

      We investigate the conditions on the additional constant μ in the so-called R + μ4/R theory of gravity, due to existence of different kinds of space-like surfaces in both weak field and strong field limits, and their possible correspondence to black hole event horizons. Adopting a Schwarzschild limit, we probe the behavior of μ in different contexts of radial and radial-rotational congruence of null geodesics. We show that these cases serve as correspondents to black hole horizons in some peculiar cases of study.

    15. Federal R&D Funding: Trends and Projections

      NASA Astrophysics Data System (ADS)

      White, K. S.

      2014-12-01

      Between sequestration, shutdowns, and budget "cliffs," the federal budget process has experienced many challenges in recent years. Budgets for research and development (R&D) have mirrored these larger fiscal constraints. Over the past decade, many agencies and programs have seen flat or declining budgets, particularly when inflation is considered. This talk will examine recent geoscience R&D funding in the historical context and examine projections of future science funding in the framework of the Budget Control Act and other initiatives.

    16. The TPX magnet R&D program

      SciTech Connect

      Zbasnik, J.P.; Hassenzahl, W.V.; Chaplin, M.R.; Slack, D.S.; Lang, D.D.; Schultz, J.H.; Citrolo, J.C.

      1993-10-06

      A unique feature of the magnet system for the Tokamak Physics Experiment (TPX) is that all the magnets are superconducting. With the exception of the outer poloidal coils, the magnet system uses Nb{sub 3}Sn cable-in-conduit conductor; the outer poloidal coils use Nb-Ti cable-in-conduit conductor. A Research and Development program is needed to ensure that the materials, processes, and systems are available to support the fabrication and operation of these magnets. The authors describe their plans for R&D in the areas of: conductor strand and sheath development, insulation materials and configuration, conductor forming, curing, and impregnation techniques, and quench detection methods and techniques. Since a significant portion of the TPX magnet system design and fabrication will be done in industry, a division of the magnet R&D effort between industry and the National Laboratories is proposed. A close liaison is maintained with the ITER magnet R&D program, and TPX will make use of ITER results whenever possible.

    17. GOES-R user data transfer mechanisms and structure

      NASA Astrophysics Data System (ADS)

      Royle, A. W.

      The National Oceanic and Atmospheric Administration (NOAA) and National Aeronautics and Space Administration (NASA) are jointly developing the next-generation series of Geostationary Operational Environmental Satellites (GOES), known as the GOES-R Series. GOES-R meteorological data is provided to the operational and science user community through four main distribution mechanisms. GOES-R generates a set of data from each of the six primary satellite instruments and formats the data into a direct broadcast stream known as GOES Rebroadcast (GRB) for hemispheric distribution via L-band satellite downlink. Terrestrially, meteorological data is provided to forecasters at the National Weather Service (NWS) through a direct interface to the Advanced Weather Interactive Processing System (AWIPS). A secondary pathway for the user community to receive data terrestrially is via the GOES-R Access Subsystem (GAS), which is being developed as a part of NOAA's Environmental Satellite Processing and Distribution System (ESPDS) Product Distribution and Access (PDA) capability. Finally, GOES-R data is made available to NOAA's Comprehensive Large Array-Data Stewardship System (CLASS) for long-term archive. This paper will provide a summary description of the data types and formats associated with each of the four primary distribution pathways for user data from GOES-R. It will discuss the resources that are being developed by GOES-R to document the data structures and formats. It will also provide a brief introduction to the types of metadata associated with each of the primary data flows.

    18. A human TAPBP (TAPASIN)-related gene, TAPBP-R.

      PubMed

      Teng, Michelle S; Stephens, Richard; Du Pasquier, Louis; Freeman, Tom; Lindquist, Jonathan A; Trowsdale, John

      2002-04-01

      TAPASIN, a V-C1 (variable-constant) immunoglobulin superfamily (IgSF) molecule that links MHC class I molecules to the transporter associated with antigen processing (TAP) in the endoplasmic reticulum (ER) is encoded by the TAPBP gene, located near to the MHC at 6p21.3. A related gene was identified at chromosome position 12p13.3 between the CD27 and VAMP1 genes near a group of MHC-paralogous loci. The gene, which we have called TAPBP-R (R for related), also encodes a member of the IgSF, TAPASIN-R. Its putative product contains similar structural motifs to TAPASIN, with some marked differences, especially in the V domain, transmembrane and cytoplasmic regions. By using the mouse ortholog to screen tissue, we revealed that the TAPBP-R gene was broadly expressed. Sub-cellular localization showed that the bulk of TAPASIN-R is located within the ER but biotinylation experiments were consistent with some expression at thecell surface. TAPASIN-R lacks an obvious ER retention signal. The function of TAPASIN-R will be of interest in regards to the evolution of the immune system as well as antigen processing. PMID:11920573

    19. Review: R28 retinal precursor cells: The first 20 years

      PubMed Central

      2014-01-01

      The R28 retinal precursor cell line was established 20 years ago, originating from a postnatal day 6 rat retinal culture immortalized with the 12S E1A (NP-040507) gene of the adenovirus in a replication-incompetent viral vector. Since that time, R28 cells have been characterized and used for a variety of in vitro and in vivo studies of retinal cell behavior, including differentiation, neuroprotection, cytotoxicity, and light stimulation, as well as retinal gene expression and neuronal function. While no cell culture is equivalent to the intact eye, R28 cells continue to provide an important experimental system for the study of many retinal processes. PMID:24644404

    20. A Research Guide on National Board Certification[R] of Teachers

      ERIC Educational Resources Information Center

      National Board for Professional Teaching Standards, 2007

      2007-01-01

      The National Board for Professional Teaching Standards[R] (NBPTS) has always welcomed scrutiny of the National Board Certification[R] process and the impact that National Board Certified Teachers[R] (NBCTs) have on teaching and learning. As a result, in the 20 years since NBPTS was founded, National Board Certification has become one of the most…

    1. miR-92a family and their target genes in tumorigenesis and metastasis

      SciTech Connect

      Li, Molin; Guan, Xingfang; Sun, Yuqiang; Mi, Jun; Shu, Xiaohong; Liu, Fang; Li, Chuangang

      2014-04-15

      The miR-92a family, including miR-25, miR-92a-1, miR-92a-2 and miR-363, arises from three different paralog clusters miR-17-92, miR-106a-363, and miR-106b-25 that are highly conservative in the process of evolution, and it was thought as a group of microRNAs (miRNAs) correlated with endothelial cells. Aberrant expression of miR-92a family was detected in multiple cancers, and the disturbance of miR-92a family was related with tumorigenesis and tumor development. In this review, the progress on the relationship between miR-92a family and their target genes and malignant tumors will be summarized. - Highlights: • Aberrant expression of miR-92a, miR-25 and miR-363 can be observed in many kinds of malignant tumors. • The expression of miR-92a family is regulated by LOH, epigenetic alteration, transcriptional factors such as SP1, MYC, E2F, wild-type p53 etc. • Roles of miR-92a family in tumorigenesis and development: promoting cell proliferation, invasion and metastasis, inhibiting cell apoptosis.

    2. Calibrating coastal GNSS-R instrumentation

      NASA Astrophysics Data System (ADS)

      Löfgren, Johan; Haas, Rüdiger; Hobiger, Thomas

      2015-04-01

      Since 2011, a GNSS-R (Global Navigation Satellite System - Reflectometry) instrument for local sea level observations is operated at the Onsala Space Observatory (Löfgren et al., 2011). The Onsala Space Observatory is the Swedish geodetic fundamental station, located at the Swedish West Coast, and contributes to the Global Geodetic Observing System (GGOS) by a variety of geodetic and geophysical observations. The Onsala GNSS-R instrumentation consists of two GNSS antennas that are mounted back-to-back on a bar at the coastline extending over the open sea in southward direction. One of the antennas is upward oriented and receives the direct satellite signals, while the other antenna is downward oriented and receives the satellite signals that reflect off the sea surface. The antennas are connected to a commercial GNSS receiver each and data are recorded with sampling rate of up to 20 Hz. Satellite signals of several GNSS are received and are analysed with various different analysis strategies to provide sea level results with different temporal resolution and precision (Larson et al., 2013; Löfgren and Haas, 2014). Since the instrumentation uses GNSS signals, it is possible to derive both local sea level, i.e. relative to the coast, and absolute sea level, i.e. relative to the geocentre as realised by the GNSS. The bar carrying the two antennas can be placed in 10 different vertical positions covering a height difference of 2.5 m between the highest and lowest position. We present results from a calibration campaign of the Onsala GNSS-R instrumentation performed in 2014. During this several weeks long campaign the antennas were placed at different vertical positions for several days at each position. The recorded data are analysed with the different analysis strategies, and the results are compared to the results derived from the co-located tide gauge equipment. References - Löfgren J, Haas R, Scherneck H-G (2011). Three months of local sea-level derived from reflected GNSS signals. Radio Science, 46, (RS0C05), doi:10.1029/2011RS004693 - Larson K, Löfgren J, Haas R (2013) Coastal sea level measurements using a single geodetic GPS receiver. Advances in Space Research, 51, 1301-1310, doi:10.1016/j.asr.2012.04.017 - Löfgren J, Haas R (2014) Sea level measurements using multi-frequency GPS and GLONASS observations. EURASIP Journal on Advances in Signal Processing 2014, 2014:50, doi:10.1186/1687-6180-2014-50

    3. Synthesis of (3R,5R)-harzialactone A and its (3R,5S)-isomer

      PubMed Central

      Srinivas, Rangavajjula; Das, Sukant K; Yadav, Jhillu S

      2010-01-01

      Summary The total synthesis of (3R,5R)-harzialactone A (1) and its (3R,5S)-isomer (2) is described. Epoxide opening with thioacetal and diastereoselective reductions are used as key reactions. PMID:20485590

    4. Studies on synthetic LuxR solo hybrids.

      PubMed

      da Silva, Daniel Passos; Patel, Hitendra K; Gonzlez, Juan F; Devescovi, Giulia; Meng, Xianfa; Covaceuszach, Sonia; Lamba, Doriano; Subramoni, Sujatha; Venturi, Vittorio

      2015-01-01

      A sub-group of LuxR family of proteins that plays important roles in quorum sensing, a process of cell-cell communication, is widespread in proteobacteria. These proteins have a typical modular structure consisting of N-ter autoinducer binding and C-ter helix-turn-helix (HTH) DNA binding domains. The autoinducer binding domain recognizes signaling molecules which are most often N-acyl homoserine lactones (AHLs) but could also be other novel and yet unidentified molecules. In this study we carried out a series of specific domain swapping and promoter activation experiments as a first step to engineer synthetic signaling modules, taking advantage of the modularity and the versatile/diverse signal specificities of LuxR proteins. In our experiments the N-ter domains from different LuxR homologs were either interchanged or placed in tandem followed by a C-ter domain. The rational design of the hybrid proteins was supported by a structure-based homology modeling studies of three members of the LuxR family (i.e., LasR, RhlR, and OryR being chosen for their unique ligand binding specificities) and of selected chimeras. Our results reveal that these LuxR homologs were able to activate promoter elements that were not their usual targets; we also show that hybrid LuxR proteins retained the ability to recognize the signal specific for their N- ter autoinducer binding domain. However, the activity of hybrid LuxR proteins containing two AHL binding domains in tandem appears to depend on the organization and nature of the introduced domains. This study represents advances in the understanding of the modularity of LuxR proteins and provides additional possibilities to use hybrid proteins in both basic and applied synthetic biology based research. PMID:26151032

    5. Evaluation of miR-29c, miR-124, miR-135a and miR-148a in predicting lymph node metastasis and tumor stage of gastric cancer

      PubMed Central

      Liu, Li; Ye, Jia-Xiang; Qin, Yu-Zhou; Chen, Qi-Huang; Ge, Lian-Ying

      2015-01-01

      MicroRNAs (miRNAs) are small noncoding RNA that have diverse functions in different biological process. The aim of this study was to evaluate the predictive ability of miR-29c, miR-124, miR-135a and miR-148a for lymph node metastasis (LNM) and tumor stage in gastric cancer. The expression of these miRNAs was detected and quantitated in gastric cancer tissues and in adjacent normal tissues from 60 patients by quantitative real-time reverse transcription-polymerase chain reaction. CT imaging and clinicopathologic characteristics of these patients were performed. The result of this study was that these miRNAs were down-regulated in gastric cancer tissues; The low expression of miR-124 and miR-135a in LNM group and tumor III-IV stages (P < 0.01) presented the potential correlation with LNM and tumor stage; The two miRNAs were highly correlated with r = 0.730. Receiver operating characteristic curve analysis showed that miR-124 had better predictive ability to identify LNM and tumor stage. It could discriminate non-LNM from LNM with 80.0% sensitivity and 80.0% specificity and discriminate tumor Ι-II stages from tumor III-IV stages with 71.9% sensitivity and 75.0% specificity at the best cut-off value of 0.0125. Compared with CT imaging, miR-124 had similar specificity (0.800 versus 0.900, P = 0.508) but higher sensitivity (0.800 versus 0.500, P = 0.022) for lymph node assessment; Combined of miR-124 and CT imaging, The sensitivity and specificity of assessing LNM were raised to 83.3% and 90.0% respectively. Taken together, miR-124 may be a predictor for LNM and tumor stage in gastric cancer. PMID:26885198

    6. Studies on synthetic LuxR solo hybrids

      PubMed Central

      Passos da Silva, Daniel; Patel, Hitendra K.; González, Juan F.; Devescovi, Giulia; Meng, Xianfa; Covaceuszach, Sonia; Lamba, Doriano; Subramoni, Sujatha; Venturi, Vittorio

      2015-01-01

      A sub-group of LuxR family of proteins that plays important roles in quorum sensing, a process of cell-cell communication, is widespread in proteobacteria. These proteins have a typical modular structure consisting of N-ter autoinducer binding and C-ter helix-turn-helix (HTH) DNA binding domains. The autoinducer binding domain recognizes signaling molecules which are most often N-acyl homoserine lactones (AHLs) but could also be other novel and yet unidentified molecules. In this study we carried out a series of specific domain swapping and promoter activation experiments as a first step to engineer synthetic signaling modules, taking advantage of the modularity and the versatile/diverse signal specificities of LuxR proteins. In our experiments the N-ter domains from different LuxR homologs were either interchanged or placed in tandem followed by a C-ter domain. The rational design of the hybrid proteins was supported by a structure-based homology modeling studies of three members of the LuxR family (i.e., LasR, RhlR, and OryR being chosen for their unique ligand binding specificities) and of selected chimeras. Our results reveal that these LuxR homologs were able to activate promoter elements that were not their usual targets; we also show that hybrid LuxR proteins retained the ability to recognize the signal specific for their N- ter autoinducer binding domain. However, the activity of hybrid LuxR proteins containing two AHL binding domains in tandem appears to depend on the organization and nature of the introduced domains. This study represents advances in the understanding of the modularity of LuxR proteins and provides additional possibilities to use hybrid proteins in both basic and applied synthetic biology based research. PMID:26151032

    7. [Statistical analysis using freely-available "EZR (Easy R)" software].

      PubMed

      Kanda, Yoshinobu

      2015-10-01

      Clinicians must often perform statistical analyses for purposes such evaluating preexisting evidence and designing or executing clinical studies. R is a free software environment for statistical computing. R supports many statistical analysis functions, but does not incorporate a statistical graphical user interface (GUI). The R commander provides an easy-to-use basic-statistics GUI for R. However, the statistical function of the R commander is limited, especially in the field of biostatistics. Therefore, the author added several important statistical functions to the R commander and named it "EZR (Easy R)", which is now being distributed on the following website: http://www.jichi.ac.jp/saitama-sct/. EZR allows the application of statistical functions that are frequently used in clinical studies, such as survival analyses, including competing risk analyses and the use of time-dependent covariates and so on, by point-and-click access. In addition, by saving the script automatically created by EZR, users can learn R script writing, maintain the traceability of the analysis, and assure that the statistical process is overseen by a supervisor. PMID:26458467

    8. A mitochondrial rRNA dimethyladenosine methyltransferase in Arabidopsis

      PubMed Central

      Richter, Uwe; Kühn, Kristina; Okada, Sachiko; Brennicke, Axel; Weihe, Andreas; Börner, Thomas

      2010-01-01

      S-adenosyl-l-methionine-dependent rRNA dimethylases mediate the methylation of two conserved adenosines near the 3′ end of the rRNA in the small ribosomal subunits of bacteria, archaea and eukaryotes. Proteins related to this family of dimethylases play an essential role as transcription factors (mtTFBs) in fungal and animal mitochondria. Human mitochondrial rRNA is methylated and human mitochondria contain two related mtTFBs, one proposed to act as rRNA dimethylase, the other as transcription factor. The nuclear genome of Arabidopsis thaliana encodes three dimethylase/mtTFB-like proteins, one of which, Dim1B, is shown here to be imported into mitochondria. Transcription initiation by mitochondrial RNA polymerases appears not to be stimulated by Dim1B in vitro. In line with this finding, phylogenetic analyses revealed Dim1B to be more closely related to a group of eukaryotic non-mitochondrial rRNA dimethylases (Dim1s) than to fungal and animal mtTFBs. We found that Dim1B was capable of substituting the E. coli rRNA dimethylase activity of KsgA. Moreover, we observed methylation of the conserved adenines in the 18S rRNA of Arabidopsis mitochondria; this modification was not detectable in a mutant lacking Dim1B. These data provide evidence: (i) for rRNA methylation in Arabidopsis mitochondria; and (ii) that Dim1B is the enzyme catalyzing this process. PMID:19929881

    9. 75 FR 14069 - Amendment of Using Agency for Restricted Areas R-3005A, R-3305B, R-3005C, R-3005D and R-3005E...

      Federal Register 2010, 2011, 2012, 2013, 2014

      2010-03-24

      ... follows: Authority: 49 U.S.C. 106(g), 40103, 40113, 40120; E.O. 10854, 24 FR 9565, 3 CFR, 1959-1963 Comp... 12866; (2) is not a ``significant rule'' under DOT Regulatory Policies and Procedures (44 FR 11034... Administration 14 CFR Part 73 RIN 2120-AA66 Amendment of Using Agency for Restricted Areas R-3005A, R-3305B,...

    10. R: a statistical environment for hydrological analysis

      NASA Astrophysics Data System (ADS)

      Zambrano-Bigiarini, Mauricio; Bellin, Alberto

      2010-05-01

      The free software environment for statistical computing and graphics "R" has been developed and it is maintained by statistical programmers, with the support of an increasing community of users with many different backgrounds, which allows access to both well-established and experimental techniques. Hydrological modelling practitioners spent large amount of time in pre- and post-processing data and results with traditional instruments. In this work "R" and some of its packages are presented as powerful tools to explore and extract patterns from raw information, to pre-process input data of hydrological models, and post-processing its results. In particular, examples are taken from analysing 30-years of daily data for a basin of 85000 km2, saving a large amount of time that could be better spent in doing analysis. In doing so, vectorial and raster GIS files were imported, for carrying out spatial and geostatistical analysis. Thousands of raw text files with time series of precipitation, temperature and streamflow were summarized and organized. Gauging stations to be used in the modelling process are selected according to the amount of days with information, and missing time series data are filled in using spatial interpolation. Time series on the gauging stations are summarized through daily, monthly and annual plots. Input files in dbase format are automatically created in a batch process. Results of a hydrological model are compared with observed values through plots and numerical goodness of fit indexes. Two packages specifically developed to assists hydrologists in the previous tasks are briefly presented. At the end, we think the "R" environment would be a valuable tool to support undergraduate and graduate education in hydrology, because it is helpful to capture the main features of large amount of data; it is a flexible and fully functional programming language, able to be interfaced to existing Fortran and C code and well suited to the ever growing demands of hydrological analysis; and finally because it is a promising environment for tackling most of the practical problems that reality poses to the hydrological modeller.

    11. Clementine Sensor Processing System

      NASA Technical Reports Server (NTRS)

      Feldstein, A. A.

      1993-01-01

      The design of the DSPSE Satellite Controller (DSC) is baselined as a single-string satellite controller. The DSC performs two main functions: health and maintenance of the spacecraft; and image capture, storage, and playback. The DSC contains two processors: a radiation-hardened Mil-Std-1750, and a commercial R3000. The Mil-Std-1750 processor performs all housekeeping operations, while the R3000 is mainly used to perform the image processing functions associated with the navigation functions, as well as performing various experiments. The DSC also contains a data handling unit (DHU) used to interface to various spacecraft imaging sensors and to capture, compress, and store selected images onto the solid-state data recorder. The development of the DSC evolved from several key requirements; the DSPSE satellite was to do the following: (1) have a radiation-hardened spacecraft control system and be immune to single-event upsets (SEU's); (2) use an R3000-based processor to run the star tracker software that was developed by SDIO (due to schedule and cost constraints, there was no time to port the software to a radiation-hardened processor); and (3) fly a commercial processor to verify its suitability for use in a space environment. In order to enhance the DSC reliability, the system was designed with multiple processing paths. These multiple processing paths provide for greater tolerance to various component failures. The DSC was designed so that all housekeeping processing functions are performed by either the Mil-Std-1750 processor or the R3000 processor. The image capture and storage is performed either by the DHU or the R3000 processor.

    12. Dynamical F(r) Gravities

      NASA Astrophysics Data System (ADS)

      Dzhunushaliev, Vladimir

      It is offered that F(R) modified gravities can be considered as nonperturbative quantum effects arising from Einstein gravity. It is assumed that nonperturbative quantum effects gives rise to the fact that the connection becomes incompatible with the metric, the metric factors and the square of the connection in Einstein-Hilbert Lagrangian have nonperturbative additions. In the simplest approximation both additions can be considered as functions of one scalar field. The scalar field can be excluded from the Lagrangian obtaining F(R) gravity. The essence of quantum correction to the affine connection as a torsion is discussed.

    13. vipR: variant identification in pooled DNA using R

      PubMed Central

      Altmann, Andre; Weber, Peter; Quast, Carina; Rex-Haffner, Monika; Binder, Elisabeth B.; Müller-Myhsok, Bertram

      2011-01-01

      Motivation: High-throughput-sequencing (HTS) technologies are the method of choice for screening the human genome for rare sequence variants causing susceptibility to complex diseases. Unfortunately, preparation of samples for a large number of individuals is still very cost- and labor intensive. Thus, recently, screens for rare sequence variants were carried out in samples of pooled DNA, in which equimolar amounts of DNA from multiple individuals are mixed prior to sequencing with HTS. The resulting sequence data, however, poses a bioinformatics challenge: the discrimination of sequencing errors from real sequence variants present at a low frequency in the DNA pool. Results: Our method vipR uses data from multiple DNA pools in order to compensate for differences in sequencing error rates along the sequenced region. More precisely, instead of aiming at discriminating sequence variants from sequencing errors, vipR identifies sequence positions that exhibit significantly different minor allele frequencies in at least two DNA pools using the Skellam distribution. The performance of vipR was compared with three other models on data from a targeted resequencing study of the TMEM132D locus in 600 individuals distributed over four DNA pools. Performance of the methods was computed on SNPs that were also genotyped individually using a MALDI-TOF technique. On a set of 82 sequence variants, vipR achieved an average sensitivity of 0.80 at an average specificity of 0.92, thus outperforming the reference methods by at least 0.17 in specificity at comparable sensitivity. Availability: The code of vipR is freely available via: http://sourceforge.net/projects/htsvipr/ Contact: altmann@mpipsykl.mpg.de PMID:21685105

    14. Enhanced Weather Radar (EWxR) System

      NASA Technical Reports Server (NTRS)

      Kronfeld, Kevin M. (Technical Monitor)

      2003-01-01

      An airborne weather radar system, the Enhanced Weather Radar (EWxR), with enhanced on-board weather radar data processing was developed and tested. The system features additional weather data that is uplinked from ground-based sources, specialized data processing, and limited automatic radar control to search for hazardous weather. National Weather Service (NWS) ground-based Next Generation Radar (NEXRAD) information is used by the EWxR system to augment the on-board weather radar information. The system will simultaneously display NEXRAD and on-board weather radar information in a split-view format. The on-board weather radar includes an automated or hands-free storm-finding feature that optimizes the radar returns by automatically adjusting the tilt and range settings for the current altitude above the terrain and searches for storm cells near the atmospheric 0-degree isotherm. A rule-based decision aid was developed to automatically characterize cells as hazardous, possibly-hazardous, or non-hazardous based upon attributes of that cell. Cell attributes are determined based on data from the on-board radar and from ground-based radars. A flight path impact prediction algorithm was developed to help pilots to avoid hazardous weather along their flight plan and their mission. During development the system was tested on the NASA B757 aircraft and final tests were conducted on the Rockwell Collins Sabreliner.

    15. Cerebral hemodynamics in patients with chronic obstructive carotid disease by rCBF, rCBV, and rCBV/rCBF ratio using SPECT

      SciTech Connect

      Toyama, H.; Takeshita, G.; Takeuchi, A.; Anno, H.; Ejiri, K.; Maeda, H.; Katada, K.; Koga, S.; Ishiyama, N.; Kanno, T. )

      1990-01-01

      To evaluate cerebral hemodynamics, 21 patients with chronic occlusion or severe stenosis of the internal carotid or middle cerebral artery with normal or only lacunar infarction on x-ray CT were studied using single photon emission computed tomography (SPECT). We measured rCBV with 99mTc erythrocytes after rCBF with 133Xe, and calculated rCBV/rCBF. rCBF and rCBV of the 25 affected hemispheres were classified as (a) patients with normal rCBF (type I (n = 7) and type II (n = 3)); (b) patients with decreased rCBF (type III (n = 6) and type IV (n = 9)). These two groups then could be subdivided according to findings of rCBV, normal, and increased blood volumes. rCBV/rCBF increased as the cerebral perfusion pressure dropped from type I to type III. In type IV, other situations but cerebral autoregulation could be assumed. rCBV/rCBF signifies vascular mean transit time. Type III (high rCBV/rCBF) assumed as the increased OEF, misery perfusion as reported in PET. We propose rCBF, rCBV and rCBV/rCBF using SPECT can be an index for cerebral circulatory reserve.

    16. Engineered Serratia marcescens for efficient (3R)-acetoin and (2R,3R)-2,3-butanediol production.

      PubMed

      Bai, Fangmin; Dai, Lu; Fan, Jiying; Truong, Ngoctu; Rao, Ben; Zhang, Liaoyuan; Shen, Yaling

      2015-05-01

      (3R)-Acetoin and (2R,3R)-2,3-butanediol are important pharmaceutical intermediates. However, until now, the quantity of natural microorganisms with the ability to produce single configuration of optically pure (3R)-acetoin and (2R,3R)-2,3-butanediol is rare. In this study, a meso-2,3-butanediol dehydrogenase encoded by the slaC gene from Serratia marcescens MG1 was identified for meso-2,3-butanediol and (2S,3S)-2,3-butanediol biosynthesis. Inactivation of the slaC gene could significantly decrease meso-2,3-butanediol and (2S,3S)-2,3-butanediol and result in a large quantity of (3R)-acetoin accumulation. Furthermore, a (2R,3R)-2,3-butanediol dehydrogenase encoded by the bdhA gene from Bacillus subtilis 168 was introduced into the slaC mutant strain of Serratia marcescens MG1. Excess (2R,3R)-2,3-butanediol dehydrogenase could accelerate the reaction from (3R)-acetoin to (2R,3R)-2,3-butanediol and lead to (2R,3R)-2,3-butanediol accumulation. In fed-batch fermentation, the excess (2R,3R)-2,3-butanediol dehydrogenase expression strain could produce 89.81 g/l (2R,3R)-2,3-butanediol with a productivity of 1.91 g/l/h at 48 h. These results provided potential applications for (3R)-acetoin and (2R,3R)-2,3-butanediol production. PMID:25663525

    17. R-HYPE - an open R-package for management and evaluation of HYPE-data

      NASA Astrophysics Data System (ADS)

      Capell, Rene; Strömbäck, Lena; Gustafsson, David

      2015-04-01

      The Hydrological Predictions for the Environment (HYPE) model is a dynamic, semi-distributed, process-based, integrated catchment model. It uses well-known hydrological and nutrient transport concepts and can be applied for both small and large scale assessments of water resources and status. The model uses a sub-catchment approach to discretize the model domain. Within sub-catchments, a hydrological response unit (HRU) approach is used to calculate the model response. HYPE source code and tools are available through the HYPE Open Source Community (OSC) website (hype.sourceforge.net). HYPE code is released by the SMHI under the Lesser GNU Public to strengthen international collaboration in hydrological modelling and hydrological data production. New versions of the main code are delivered frequently as new versions of the HYPE model are developed. HYPE OSC is open to everyone interested in hydrology, hydrological modelling and code development - e.g. scientists, authorities, and consultancies. To support users, HYPE OSC contains manuals, wiki-pages, sample models and tools. One such tool is R-HYPE. R-HYPE is an R add-on package, providing a continuously growing set of functions to support and simplify processing files and analyzing results of the HYPE model. HYPE is typically used in large scale model set-ups which involves large data sets. Analysing such data requires recurring data handling operations and analysis steps. RHYPE strives to simplify these frequently needed analysis steps in order to support users in their specific research tasks. The current version of the package contains functionality for: - Importing HYPE model set-up and data files as well as model result files into an R workspace - Analyzing and manipulating a HYPE model set-up - Identifying and analyzing model sub-sets or specific sub-catchments - Analysing and manipulating forcing data sets - Plotting results - Exporting data from R into HYPE files R-HYPE is currently hosted on GitHub (https://github.com/rcapell/RHYPE). Latest development versions of the package can be installed using the 'devtools' package (http://cran.r-project.org/web/packages/devtools), which allows direct package installation from GitHub repositories. As package development is continuously ongoing, we encourage users to request functionalities through the GitHub issue tracker.

    18. miR-93 functions as an oncomiR for the downregulation of PDCD4 in gastric carcinoma

      PubMed Central

      Liang, Hongwei; Wang, Feng; Chu, Danping; Zhang, Weijie; Liao, Zhicong; Fu, Zheng; Yan, Xin; Zhu, Hao; Guo, Wen; Zhang, Yujing; Guan, Wenxian; Chen, Xi

      2016-01-01

      Programmed cell death 4 (PDCD4), as a tumor suppressor gene, is frequently reduced in a variety of tumors, including gastric cancer. Previous findings have indicated that PDCD4 participates in tumorigenesis through the regulation of apoptosis, but the molecular basis of this process has not been fully elucidated, and no studies have shown the upstream regulation of this gene in gastric cancer. In this study, we used bioinformatics analysis to search for miRNAs that could potentially target PDCD4 and identified miR-93 as a candidate. Moreover, we observed the inverse correlation between miR-93 and PDCD4 protein levels, but not mRNA levels, in human gastric cancer tissues. We further experimentally validated PDCD4 as the direct target of miR-93 by evaluating PDCD4 expression in gastric cancer cells after the overexpression or knockdown of miR-93. Additionally, the biological consequences of targeting PDCD4 through miR-93 were examined using cell apoptosis assays in vitro. We demonstrated that the repression of PDCD4 through miR-93 suppressed the apoptosis of gastric cancer cells. Finally, we revealed that miR-93 promoted the development of gastric tumor growth in xenograft mice by negatively regulating PDCD4. Taken together, the findings of the present study indicated the oncogenic role of miR-93 in gastric cancer tumorigenesis through targeting PDCD4, particularly in apoptosis. PMID:27021515

    19. The Eucalyptus grandis R2R3-MYB transcription factor family: evidence for woody growth-related evolution and function.

      PubMed

      Soler, Marçal; Camargo, Eduardo Leal Oliveira; Carocha, Victor; Cassan-Wang, Hua; San Clemente, Hélène; Savelli, Bruno; Hefer, Charles A; Paiva, Jorge A Pinto; Myburg, Alexander A; Grima-Pettenati, Jacqueline

      2015-06-01

      The R2R3-MYB family, one of the largest transcription factor families in higher plants, controls a wide variety of plant-specific processes including, notably, phenylpropanoid metabolism and secondary cell wall formation. We performed a genome-wide analysis of this superfamily in Eucalyptus, one of the most planted hardwood trees world-wide. A total of 141 predicted R2R3-MYB sequences identified in the Eucalyptus grandis genome sequence were subjected to comparative phylogenetic analyses with Arabidopsis thaliana, Oryza sativa, Populus trichocarpa and Vitis vinifera. We analysed features such as gene structure, conserved motifs and genome location. Transcript abundance patterns were assessed by RNAseq and validated by high-throughput quantitative PCR. We found some R2R3-MYB subgroups with expanded membership in E. grandis, V. vinifera and P. trichocarpa, and others preferentially found in woody species, suggesting diversification of specific functions in woody plants. By contrast, subgroups containing key genes regulating lignin biosynthesis and secondary cell wall formation are more conserved across all of the species analysed. In Eucalyptus, R2R3-MYB tandem gene duplications seem to disproportionately affect woody-preferential and woody-expanded subgroups. Interestingly, some of the genes belonging to woody-preferential subgroups show higher expression in the cambial region, suggesting a putative role in the regulation of secondary growth. PMID:25250741

    20. Sparse Fusion Imaging for a Moving Target in T/R-R Configuration

      PubMed Central

      Chai, Shougang; Chen, Weidong; Chen, Chang

      2014-01-01

      For high resolution imaging of a non-cooperative moving target, this paper proposes a sparse fusion imaging method. The imaging system contains two radar stations, which are separated by a certain bistatic angle and configured in a transmitter/receiver-receiver (T/R-R) manner. Consequently, two synthetic apertures are obtained at the same time from different aspect angles. By coherently fusing the echoes of the two radars, a virtual aperture spanned by these two sub-apertures can be constructed, which is larger than either of the sub-apertures; thus, the cross-range resolution of the image is enhanced. Moreover, the fusion of the echoes is realized by exploiting the sparse scattering property of the target. Then, based on the maximum a posteriori (MAP) criterion, the T/R-R fusion imaging problem is converted into a sparse signal recovery problem with unknown parameters. Finally, it is solved in an iterative manner, which contains two steps, i.e., sparse imaging and parameter estimation. Simulation results show that the proposed sparse fusion imaging method can improve the cross-range resolution significantly compared to inverse synthetic aperture radar (ISAR) within the same coherent processing interval (CPI). PMID:24940867