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La malattia ischemica del miocardio oltre la stenosi coronarica: valore fisiopatologico e clinico della scintigrafia miocardica di perfusione con tecnica gated-SPECT  

Microsoft Academic Search

Lo studio angiografico dei vasi coronarici epicardici è la più accurata tecnica per valutare l'anatomia coronarica. Tuttavia, è sempre più evidente che la prognosi del paziente non dipende solo dal flusso angiografico nelle arterie epicardiche, ma anche da eventi che si realizzano a valle della stenosi coronarica, che condizionano tanto la fisiopatologia dell'ischemia miocardica quanto l'outcome clinico. Infatti, lo squilibrio

M. Spadafora; L. Mansi



Aminoacidi liberi plasmatici nel diabetico dopo trattamento con insulina ed ipoglicemizzante orale  

Microsoft Academic Search

Riassunto In 30 pazienti diabetici (15 maschi e 15 femmine) sono stati determinati gli aminoacidi liberi plasmatici dopo trattamento con insulina (20 casi) e con ipoglicemizzante orale (10 casi), a compenso clinico e metabolico raggiunto. Il confronto statistico con i dati rilevati prima del trattamento terapeutico e con quelli relativi a 30 soggetti normali ha evidenziato l'azione «mirata» dell'insulina esogena,

Alberto M. Bertolini; Arturo Santagostino



[Clinico-epidemiologic characteristics of the health status of miners].  


Clinico-epidemiological examination of 1944 miners working in mines with sloping layers revealed the incidence of diseases of the main systems of the body. It was found that emotional stresses further the development of primary hypertension in miners with a small length of work. Nonprofessional changes of the hearing organ are evaluated. PMID:2609603

Nekhorosheva, M A; Menia?lo, N I; Valutsina, V M; Kiva, A I; Pankina, O E



Clinico-bacteriological Profile and Outcome of Empyema.  


Empyema thoracis is a common cause of morbidity in children. We conducted a prospective observational study in 50 children (age 0-15 y) diagnosed with empyema to study its clinico-bacteriological profile and outcome in a referral hospital. Staphylococcus aureus was the most common causative organism, most of them being MRSA, followed by Pneumococcus and Pseudomonas. Primary video-assisted thoracoscopy appeared to be a good mode of management with lesser duration of hospital stay. However, the number of children undergoing this procedure was very less, to come to any conclusion. PMID:23502667

Narayanappa, D; Rashmi, N; Prasad, N A; Kumar, Anil



[Various clinico-social aspects of differential diagnosis of schizophrenia].  


Fifty-six cases where the diagnosis of psychopathy was replaced by that of schizophrenia, 44 cases where the diagnosis of organic brain damage was replaced by schizophrenia, and 45 cases of the replacement of the diagnosis of schizophrenia by organic brain damage on repeated forensic psychiatry expert evaluation were subjected to a ++clinico-catamnestic analysis. The author describes the main ++clinico-social phenomena imitating some signs of the initially diagnosed disease and/or "overshadowing" criteria for the catamnestically verified pattern of psychopathology in psychopath-like conditions and delineates some combinations of such conditions. Proceeding from limited potentialities of " algorithms " of the diagnostic problems in psychiatry, especially with regard to the pathomorphosis as well as because of the complexity of forecasting particular signs and their number that may form a sufficient basis for correct or erroneous diagnosis in spite of a comparatively low incidence of the majority of the phenomena considered, all of them are regarded as practically significant. PMID:1661464

Oskolkova, S N



Beyond cortical localization in clinico-anatomical correlation.  


Last year was the 150th anniversary of Paul Broca's landmark case report on speech disorder that paved the way for subsequent studies of cortical localization of higher cognitive functions. However, many complex functions rely on the activity of distributed networks rather than single cortical areas. Hence, it is important to understand how brain regions are linked within large-scale networks and to map lesions onto connecting white matter tracts. To facilitate this network approach we provide a synopsis of classical neurological syndromes associated with frontal, parietal, occipital, temporal and limbic lesions. A review of tractography studies in a variety of neuropsychiatric disorders is also included. The synopsis is accompanied by a new atlas of the human white matter connections based on diffusion tensor tractography freely downloadable on Clinicians can use the maps to accurately identify the tract affected by lesions visible on conventional CT or MRI. The atlas will also assist researchers to interpret their group analysis results. We hope that the synopsis and the atlas by allowing a precise localization of white matter lesions and associated symptoms will facilitate future work on the functional correlates of human neural networks as derived from the study of clinical populations. Our goal is to stimulate clinicians to develop a critical approach to clinico-anatomical correlative studies and broaden their view of clinical anatomy beyond the cortical surface in order to encompass the dysfunction related to connecting pathways. PMID:22995574

Catani, Marco; Dell'acqua, Flavio; Bizzi, Alberto; Forkel, Stephanie J; Williams, Steve C; Simmons, Andrew; Murphy, Declan G; Thiebaut de Schotten, Michel



Clinico-pathological aspects of canine cutaneous and mucocutaneous plasmacytomas.  


In this study the clinico-pathological aspects of cutaneous and mucocutaneous plasmacytomas were investigated in 63 dogs (one dog with two tumours). The tumours were most commonly observed in the skin of the trunk and legs. Yorkshire Terrier (n = 8) was the most commonly affected breed and males were affected more commonly than females (36 versus 23, respectively). Plasmacytomas were histologically classified into mature, hyaline, cleaved, asynchronous, monomorphous blastic and polymorphous blastic cell types. Monomorphous blastic cell type was the most frequent type (n = 21), followed by cleaved (n = 19) and asynchronous (n = 11) cell types. Secondary amyloid depositions were observed in eight cases. Immunohistochemical staining showed monoclonal lambda light chain positivity in all cases. In the immunohistochemical staining for cyclin D1, which is a prognostic marker in human plasma cell tumours, moderate numbers of positive tumour cells were observed in only one case of (muco)cutaneous plasmacytoma. All other cases were negative or contained few positive tumour cells. On the other hand, high numbers of tumorous plasma cells reacted positively with cyclin D1 in three out of six cases of canine multiple myelomas. Prognosis of the (muco)cutaneous plasmacytomas was good, except in one dog which developed a lymphoma afterwards. No significant correlations were observed between the cell type and the location of the tumour, presence of amyloid or prognosis. PMID:12227474

Cangul, I T; Wijnen, M; Van Garderen, E; van den Ingh, T S G A M



Accuracy of clinical diagnosis of idiopathic Parkinson's disease: a clinico-pathological study of 100 cases  

Microsoft Academic Search

Few detailed clinico-pathological correlations of Parkinson's disease have been published. The pathological findings in 100 patients diagnosed prospectively by a group of consultant neurologists as having idiopathic Parkinson's disease are reported. Seventy six had nigral Lewy bodies, and in all of these Lewy bodies were also found in the cerebral cortex. In 24 cases without Lewy bodies, diagnoses included progressive

A J Hughes; S E Daniel; L Kilford; A J Lees



Clinical and clinico-pathological effects of Escherichia coli endotoxin in mature cattle.  

PubMed Central

The effects of intravenous administration of Escherichia coli endotoxin were studied in eight mature lactating cows. Three cows were studied following intrammary infection with E. coli. Significant clinical findings are presented. Significant clinico-pathological findings include leukopenia, decreased blood serum calcium concentrations and increased levels of serum glutamic-oxaloacetic transaminase and serum ornithine-carbamyl transferase. Significant elevations of plasma corticosteroids were also noted.

Griel, L C; Zarkower, A; Eberhart, R J



A clinico-pathological study of canine Cushing's disease caused by a pituitary carcinoma.  


Knowledge of clinico-pathological correlations in canine Cushing's disease is rather poor. Therefore we describe, clinically and pathologically, a case of pituitary tumour-dependent Cushing's disease in an 8-year old female cocker spaniel. Based on our results, the tumour was defined as a non-dexamethasone-suppressive, corticotrophic adenocarcinoma characterized by some new findings such as intracerebral metastases of anti-ACTH-labelled tumour cells and combined alpha-, beta- and gamma 3-MSH immunoreactivity in the tumour. PMID:1662239

Boujon, C E; Ritz, U; Rossi, G L; Bestetti, G E



Clinico-epidemiological profile of cases of fever with arthritis (Chikugunya) attending Urban Health Centre, Solapur.  


This communication describes the findings of a hospital and community survey conducted in the UHC catchment area of solapur city to find out clinico-epidemiological profile of cases of chikungunya fever during mid 2006. A total of 208 cases who attended UHC and 962 community members were studied. 20-44 was the mostly affected age-group and Females outnumber male hospital attendees. Major presenting features were fever, joint pain, bodyache, headache, nausea. In majority of patients, joint pain lasted for two months and subsided by 6th month. Of 21 samples tested, 19 showed IgM positivity for chikungunya. PMID:22010486

Gokhale, R M; Rayate, M V; Kotnis, S D; Sathe, P S



TDP43-negative FTLD-U is a significant new clinico-pathological subtype of FTLD  

Microsoft Academic Search

Frontotemporal lobar degeneration with ubiquitin-positive inclusions (FTLD-U) is the most common neuropathological subtype\\u000a of frontotemporal dementias. While TDP-43 is the pathologic protein in the majority of FTLD-U cases, small numbers of cases\\u000a have recently been reported with TDP-43-negative FTLD-U pathology. To determine the frequency and to define the clinico-pathological\\u000a spectrum of TDP-43-negative FTLD-U, we re-evaluated 44 cases with a previous

Sigrun Roeber; Ian R. A. Mackenzie; Hans A. Kretzschmar; Manuela Neumann



Can we overcome the 'clinico-radiological paradox' in multiple sclerosis?  


The association between common neuroradiological markers of multiple sclerosis (MS) and clinical disability is weak, a phenomenon known as the clinico-radiological paradox. Here, we investigated to which degree it is possible to predict individual disease profiles from conventional magnetic resonance imaging (MRI) using multivariate analysis algorithms. Specifically, we conducted cross-validated canonical correlation analyses to investigate the predictive information contained in conventional MRI data of 40 MS patients for the following clinical parameters: disease duration, motor disability (9-Hole Peg Test, Timed 25-Foot Walk Test), cognitive dysfunction (Paced Auditory Serial Addition Test), and the expanded disability status scale (EDSS). It turned out that the information in the spatial patterning of MRI data predicted the clinical scores with correlations of up to 0.80 (p < 10(-9)). Maximal predictive information for disease duration was identified in the precuneus and somatosensory cortex. Areas in the precuneus and precentral gyrus were maximally informative for motor disability. Cognitive dysfunction could best be predicted using data from the angular gyrus and superior parietal lobe. For EDSS, the inferior frontal gyrus was maximally informative. In conclusion, conventional MRI is highly predictive of clinical disability in MS when pattern-based algorithms are used for prediction. Thus, the so-called clinico-radiological paradox is not apparent when using suitable analysis techniques. PMID:22446893

Hackmack, Kerstin; Weygandt, Martin; Wuerfel, Jens; Pfueller, Caspar F; Bellmann-Strobl, Judith; Paul, Friedemann; Haynes, John-Dylan



[A swallowing study, based on clinico-pathological evaluation, performed by video-fluoroscopy].  


A clinico-pathological evaluation was performed on patients requiring nasogastric nutritional support. As a result, it was found that nasogastric tube feeding was common in patients with cerebrovascular diseases (CVD) and senile dementia of Alzheimer's type (SDAT). Pneumonia was anamnestic in many CVD patients, which was frequently the direct indication for nasogastric tube feeding and the major cause of death in these patients. On the other hand, pneumonia was not common in SDAT in which the major indication of nasogastric tube feeding was abnormal appetite. However, pneumonia was an infrequent cause of death in SDAT compared to CVD patients. The mean age in which nasogastric tube feeding was started was 8 years older in SDAT than CVD patients, however, there was no significant difference in the duration of nasogastric tube feeding ranging from initiation to death. A swallowing study, based on a clinico-pathological evaluation, was performed by video-fluoroscopy on healthy seniors and senior patients neurological diseases. There was no abnormal finding in the healthy seniors. Findings in CVD patients with single-sided neurological diseases indicated that 27.3% had moderate abnormalities and 18.2% had severe abnormalities. In CVD with bilateral defects, 35.7% had moderate abnormalities and 42.9% had severe abnormalities. Though even single-sided CVD defects can frequently cause swallowing disorder, oral food intake was maintained in nearly half of the patients with bilateral CVD, despite high incidence of severe swallowing disorder. In the mild SDAT group, rated on a scale from 0.5 to 1.0 according to the Clinical Dementia Rating (CDR), 11.1% had moderate swallowing disorder. In the CDR 2-3 group, 23.1% had moderate disability and 15.4% had severe disability. It appears that SDAT patients do not suffer from rapid deterioration in swallowing ability, which was relatively retained in this disease group. In Parkinson's disease patients with a Yahr grade of I-II, 55.6% had normal findings and 44.4% had mild abnormalities. In Yahr grade III-IV patients, 28.6% had mild and 28.6% had severe disability. Patients with severe dysfunction had a high incidence of silent aspiration. The swallowing function was maintained in the early course of mild Parkinson's disease patients, however the ability rapidly deteriorated with the course of the disease. The radiological findings of the swallowing study supported the clinico-pathological characteristics of each disease. PMID:10737024

Hasegawa, Y; Yamamoto, T; Inagaki, T; Suzuki, K



[Clinico-endoscopic classification of acute anastomositis after resection of the stomach].  


The authors have analyzed the results of resection of the stomach in 106 patients with a complicated course of ulcer disease of the stomach and duodenum. Based on a complex investigation of regeneration of the gastrointestinal anastomoses formed by different methods and a comparison of the endoscopic picture with the clinical course of the early postoperative period the authors propose a clinico-endoscopic classification of acute postgastroresectional anastomosites. Comparison of the frequency and severity of the anastomosites has shown advantages of a one-raw seroserous musculo-submucous suture in the resectional surgery of the stomach when forming gastro-intestinal anastomoses. The classification of acute anastomosites allows the timely detection and correction of the operation complications. PMID:12638493

Zhizhin, F S; Kapustin, B B



[Clinico-economical aspects of cardioversion of paroxysmal atrial fibrillation at phehospital stage and during hospitalization].  


We carried out clinico-economical analysis of 2 tactics of rhythm restoration in patients with paroxysmal atrial fibrillation (AF) lasting less than 48 hours: cardioversion at prehospital stage with intravenous procainamide and inhospital cardioversion with any method. This retrospective study was based on the data from department of urgent aid of an outpatient clinic. The results showed that within 48 hours inhospital was a was more effective, safe, and more economically profitable compared with administration of procainamide at prehospital stage. Intravenous procainamide resulted in effective cardioversion in 70.6% of patients. It was associated with arterial hypotension and proarrhythmogenic action in 14,7% of cases. Patients with effective cardioversion with procainamide had lesser mean values of left ventricular anterior-posterior dimension (echocardiography) and shorter duration of arrhythmia. PMID:22839582

Bulanova, N A; Stazhadze, L L; Sidorenko, B A



Mass spectrometry protein expression profiles in colorectal cancer tissue associated with clinico-pathological features of disease  

Microsoft Academic Search

BACKGROUND: Studies of several tumour types have shown that expression profiling of cellular protein extracted from surgical tissue specimens by direct mass spectrometry analysis can accurately discriminate tumour from normal tissue and in some cases can sub-classify disease. We have evaluated the potential value of this approach to classify various clinico-pathological features in colorectal cancer by employing matrix-assisted laser desorption

Christopher CL Liao; Nicholas Ward; Simon Marsh; Tan Arulampalam; John D Norton



[Clinico-pathological investigation of two patients with dementia with motor neuron disease].  


Dementia with motor neuron disease (D-MND) is characterized clinically by frontal and neurological signs, and pathologically by localized atrophy of the fronto-temporal lobes and neuronal ubiquitin(Ub)-positive inclusions. In this study, we compared the clinico-pathological findings of two patients with D-MND. Case 1 (55-year-old male): At the age of 51, he developed personality change and disinhibition, lacking neurological signs. Brain MRI exhibited localized atrophy of the frontal lobes. At the age of 54, he showed dysphagia and died after a disease duration of 4 years. Neuropathologically, the cerebrum showed localized atrophy of the dorsal area of the frontal lobes. The atrophied cerebral cortex demonstrated moderate neuronal loss with spongy change and gliosis in the superficial layers. The brainstem and spinal cord revealed moderate neuronal loss in the substantia nigra, severe neuronal loss with Bunina bodies in the hypoglossal nucleus, and moderate neuronal loss in the cervical anterior horn. There were some Ub-positive neuronal inclusions in the atrophied cortex and many in the dentate gyrus. Case 2 (68-year-old female): At the age of 64, she developed personality change, and then gait disturbance and dysarthria. Brain MRI exhibited localized atrophy of the fronto-temporal lobes. At the age of 67, she showed dysphagia with Babinski signs and died after a disease duration of 4 years. Neuropathologically, the cerebrum showed localized atrophy of the basal area of the temporal lobes, especially on the right side. The atrophied cerebral cortex demonstrated moderated neuronal loss with spongy change and gliosis in the superficial layers. The pre-central cortex revealed severe loss of Betz cells. The brainstem and spinal cord showed mild neuronal loss without Bunina bodies in the hypoglossal nucleus and cervical anterior horn, accompanied by severe degeneration of the bilateral pyramidal tracts. There were many Ub-positive neuronal inclusions with a few neurites in the atrophied cortex and some in the dentate gyrus. Cases 1 and 2 were clinically diagnosed as Pick's disease (PiD) and D-MND, respectively, although pathological diagnoses were both D-MND. Case 1 showed neuropathological findings typical to D-MND, whereas case 2 showed neuropathological findings common to atypical Pick's disease (aPiD). D-MND and aPiD are should be clinico-pathologically differentiated, although they are included in the frontotemporal lobar degeneration with motor neuron disease-type inclusions. PMID:17370652

Yamamoto, Ryoko; Iseki, Eizo; Murayama, Norio; Minegishi, Michiko; Kimura, Michihiro; Eto, Ko; Arai, Heii; Ohbu, Sadayoshi; Hatanaka, Daisuke; Hino, Hiroaki; Fujisawa, Koshiro



Efficacy of crystallization test for screening of oral squamous cell carcinoma with clinico-pathological correlation.  


Aim: To determine the efficacy of crystallization test for screening oral squamous cell carcinoma (OSCC) with clinico-pathologic correlation. Materials and Methods: Fifty patients of OSCC and 30 healthy individuals were selected. One drop of blood was collected into 1 cc of doubled distilled water at room temperature to give a final dilution of 6% hemolyzed blood. 0.1 to 0.2 cc of blood sample was then subjected to crystallization test using 10% cupric chloride solution. Results: In healthy control group, the typical pattern was an eccentrically placed center of gravity with needles arranged in radiating fashion, while in OSCC group, there was 'transverse form' (TF) formation. The sensitivity and specificity of this test was found to be 96% and 96.66%, respectively. The positive and negative predictive values were found to be 97.96% and 98.55%, respectively. The mean TF frequency was found to be increasing from grade I (3.20 ± 1.5%) to grade II (653 ± 2.23%) and difference was statistically significant (P = 0.0001). However, there was no correlation between mean TF frequency and TNM stages of OSCC. Conclusion: Crystallization test is a simple, reliable, economical, less time-consuming, and less invasive screening procedure, which can be used for early detection of OSCC. PMID:24047839

Sarode, Sachin C; Sarode, Gargi S; Barpande, Suresh; Tupkari, Jagdish V


Clinico-epidemiological profile of chronic suppurative otitis media patients attending a tertiary care hospital.  


The cross-sectional study was conducted to assess the clinico-epidemiological profile, perceptions and clinical profile of the chronic suppurative otitis media (CSOM) patients in a tertiary care hospital. A pretested questionnaire was used containing open questions and the patients were assessed clinically. Most patients (31.2%) were from 0-10 years age group and were males (58.8%). Majority of them (96%) lived in "kuccha" houses/slums, 76.8% practised unhygienic ear pricking, 36.8% poured oil in their ears, 70.8% bathed in ponds/rivers, 52.8% had ear discharge for more than 1 year. Among the respondents, 17.2% knew that CSOM was contagious, 24% thought CSOM ran in family, 20% knew CSOM is preventable. There was low threat perception and long time to seek care. Patients mostly presented with earache, deafness and discharge, most had deafness and safe variety of CSOM. More than half had comorbidities. Most of the previous study findings corroborated with the present study. Here was a substantial delay between the onset and treatment seeking due to lack of awareness and low threat perception. Pain and complications were the triggers for care-seeking. Education about the disease, strengthening the frontline workers and good referral system are suggested. PMID:22187766

Neogi, Rajarshi; Dan, Amit; Maity, Kuntal; Basak, Bijan; Basu, Deepjoy; Acharya, Moloy; Sengupta, Arunava; Biswas, Akhil Bandhu



Clinico-epidemiological and Socio-behavioral Study of People Living with HIV/AIDS.  


Although India is in the grip of HIV/AIDS epidemic, not much information is available on clinico-epidemiological and socio-behavioral aspects of people living with HIV/AIDS (PLWHA). This study analyzed these features using standard methodologies in 82 HIV sero-positives, AIDS patients attending ART clinic of three major government hospitals of Delhi. Majority of the patients (73%) were found to be young (<40 years) and married (79%). As high as 91.5% came from low socio-economic class and more than 95% acquired HIV transmission through heterosexual routes. A large proportion (63%) of these patients reported an extremely high level of anxiety, moderate level of stress and a borderline level of clinical depression. While most of the patients (72%) were well-adjusted with the ART, the rest of the patients reported difference in making adjustment with the treatment schedules. The study suggests that counseling and supportive therapy could play a pivotal role in controlling anxiety, stress, depression and rehabilitating people with HIV/AIDS. PMID:21799555

Khan, M A; Sehgal, A



Trapped neutrophil syndrome in a Border Collie dog: clinical, clinico-pathologic, and molecular findings.  


Trapped neutrophil syndrome (TNS) is an autosomal recessive inherited neutropenia known in Border Collies since the 1990's. Recently, the causative mutation has been identified in the canine VPS13B gene and a DNA-based diagnosis has now become available. The present paper describes clinical and clinico-pathologic findings in a Border Collie with TNS that was molecularly diagnosed for the first time in Japan. In a 10-week-old male Border Collie with microgenesis and symptoms related to recurrent infections, a hematological examination revealed severe leukopenia due to neutropenia, suggesting the dog to be affected by inherited neutropenic immunodeficiency. Direct DNA sequencing demonstrated that the dog was homozygous for the causative mutation of TNS and both its parents were heterozygous carriers. In addition, a simple and rapid polymerase chain reaction-based length polymorphism analysis coupled with microchip electrophoresis was developed for the genotyping of TNS. This assay could discriminate clearly all genotypes, suggesting that it was suitable for both individual diagnosis and large-scale surveys for prevention. PMID:22240985

Mizukami, Keijiro; Shoubudani, Tomoaki; Nishimoto, Seira; Kawamura, Ryuta; Yabuki, Akira; Yamato, Osamu



Gene methylation in pleural mesothelioma: correlations with clinico-pathological features and patient's follow-up.  


Methylation of tumor suppressor genes is among the most frequent alterations in patients with malignant pleural mesothelioma (MPM). The aim of this study was to analyze the promoter methylation status of four tumor suppressor genes, p15(INK4B), p16(INK4A), RASSF1A and NORE1A in MPM. Samples of 79 MPM patients were analyzed using a methylation-specific PCR method. Associations between methylation status, clinico-pathological parameters (including proliferation index) and overall survival (OS) were examined. The analysis documented methylation in 30 cases (38%). The methylation frequency for individual genes was 19% for p15(INK4B) (n=15), 11.4% for p16(INK4A) (n=9), 20.2% for RASSF1A (n=16) and 5.1% for Nore1A (n=4). In the whole series methylation was associated to an increased proliferation index (P=0.05). In patients treated with extrapleural pneumonectomy, methylated MPM showed a trend to a poorer OS in comparison to unmethylated cases (median OS 16 months vs. 35 months, P=0.06, HR=2.01, 95% CI 0.95-4.30). In the overall population, methylation did not correlate to patient outcome but a trend to an improved survival was detectable in ummethylated MPM treated with extrapleural pneumonectomy. This result suggests the need to select homogeneously treated and staged patients with MPM to address whether their methylation profile may impact on patient's survival. PMID:17920725

Destro, Annarita; Ceresoli, Giovanni L; Baryshnikova, Ekaterina; Garassino, Isabella; Zucali, Paolo A; De Vincenzo, Fabio; Bianchi, Paolo; Morenghi, Emanuela; Testori, Alberto; Alloisio, Marco; Santoro, Armando; Roncalli, Massimo



Pulmonary sporotrichosis: case series and systematic analysis of literature on clinico-radiological patterns and management outcomes.  


Pulmonary infections by Sporothrix spp. manifest radiologically as cavitary or non-cavitary disease depending on whether the infection is primary pulmonary or multifocal sporotrichosis. Despite current guidelines, the optimal management for pulmonary sporotrichosis remains unclear. In order to clarify this, we present two cases of pulmonary sporotrichosis, as well as the results of a comprehensive literature review of treatment outcomes based on clinico-radiological presentation patterns of the disease. A literature search of all case reports in English language over the last 50 years (1960-2010) was conducted. Data on patient characteristics, risk factors, clinico-radiological patterns, treatment modalities and outcomes were collected and analyzed. A total of 86 cases were identified, i.e., 64 (74.4%) primary pulmonary and 22 (25.6%) multifocal sporotrichosis. Radiologically, primary pulmonary disease was commonly characterized by cavity formation which was lacking in multifocal infections (P = 0.0001). Immunosuppressant use was more common in multifocal sporotrichosis (P = 0.0001), while hemoptysis was more common in primary pulmonary form (P = 0.01). No other differences in patient characteristics or risk factors were noted. Extra-pulmonary multifocal sporotrichosis most commonly involved skin (81.8%) and joints (45.4%). For patients with cavitary primary pulmonary sporotrichosis, outcomes from medical therapy alone were inferior to surgical intervention (P = 0.02). However, for both primary pulmonary and multifocal sporotrichosis with non-cavitary disease, medical therapy alone provided good outcomes. Only 12 (16.7%) cases were treated with itraconazole. Treatment of pulmonary sporotrichosis should be guided by the clinico-radiological patterns of presentation. Medical therapy alone is likely sufficient for non-cavitary disease while early surgery should be considered for cavitary primary pulmonary sporotrichosis. The experience in treating cavitary disease with itraconazole alone is limited and further data are required. PMID:23286352

Aung, Ar Kar; Teh, Bing Mei; McGrath, Christopher; Thompson, Philip J



[Clinico-genealogical and phenotypic characteristics of patients with late sequelae of closed cranio-cerebral injuries].  


As many as 100 patients with late sequelae of closed craniocerebral injuries (CCCI) and 50 healthy persons underwent a clinico-genealogical and phenotypic analysis. Multifactorial diseases (in particular essential hypertension and other cardiovascular diseases) which correlate with the clinical features of late sequelae of CCCI were noted to occur in the patients' pedigree significantly more often as compared to normal persons. The patients manifest a high frequency of the stigmas of dysembryogenesis. After CCCI part of them manifested certain hereditary diseases. Genetic risk factors should be taken into account in forecasting CCCI outcomes and planning follow up measures. PMID:2171282

Shogam, I I; Pesochina, E A



Clinico-pathological study of causes of perinatal mortality in a developing country.  


Perinatal mortality rates are an important indicator of the overall obstetric and neonatal services available, and the socio-economic status of the community. These rates are also used to identify shortcomings in services provided. The aim of this study was to identify clinical causative factors of perinatal deaths (supported by post mortem evidence where possible). This was a prospective descriptive study. The total number of deliveries and perinatal deaths over a 6-month period were recorded and clinico-demographic data noted. Post mortem examination information, if available, was also recorded. There was a total of 7789 deliveries over the 6-month period and 460 perinatal deaths, giving a perinatal mortality rate of 59/1000 deliveries; 45% (n = 207) of the perinatal deaths had post mortem examinations. The mean age was 26 years; 84.8% were single mothers. One-third of the group were un-booked: the mean gestational age of fetal death was 31 weeks, and the mean birth weight was 1700 g. Two-thirds of the perinatal deaths were stillbirths. The leading obstetric causes of deaths were: abruptio placentae (25.3%), hypertension in pregnancy (24.9%), prematurity (17.4%), unexplained stillbirth (13.4%) and intrapartum asphyxia (9.2%). The perinatal mortality rate of 59/1000 deliveries is high. Although this is comparable with other developing countries, there is a need for improvement in organisation of obstetric and neonatal care, staffing levels and access to and effective utilisation of antenatal services. These will probably lead to a significant reduction of this relatively high perinatal mortality rate. PMID:12521794

Naidu, S; Moodley, J; Adhikari, M; Ramsaroop, R; Morar, N; Dunmoye, O O



Clinico-hematological profile of hereditary spherocytosis: experience from a tertiary care center in North India.  


Hereditary spherocytosis (HS) is an inherited membranopathy characterized by phenotypic and genotypic heterogeneity. This study describes the clinico-hematological profile of 70 HS patients diagnosed at a tertiary care center in North India over a period of five years. Patients commonly presented with intermittent jaundice (82.9%), pallor (80%) and dark colored urine (11.4%). The common signs were splenomegaly (92.9%), hepatomegaly (50%), cholelithiasis or choledocholithiasis (36.8%) and hemolytic facies (10%). Family history was contributory in 28.6% patients. Blood transfusion (BT) requirement was present in 35.7% patients. Unconjugated and conjugated hyperbilirubinemia was seen in 89.1 and 10.9% patients respectively. At presentation, the hemoglobin ranged from 3-14 g/dl with a mean of 9.37 g/dl (SD2.43). Spherocytes were seen in 88.6% and incubated Osmotic fragility test (OFT) was positive in 88.2% patients. The Eosin-5-maleimide (EMA) flow cytometric test was done in 28 patients. Mean fluorescence intensity (MFI) for normal subjects was 11861.5 (SD-883.51) and for confirmed HS patients was 7949.3 (SD1304.1). Taking the MFI range of 5341.1-10 557.5 for HS, eight cases of suspected HS/undiagnosed hemolytic anemia with a negative (n=5) or equivocal (n=3) incubated OFT were diagnosed as HS. An increase in HbF level was seen in 10 cases ranging from 2.1 to 17.7% with a mean of 5.66%, three of these had associated beta thalassaemia trait. Twelve patients (17%) underwent splenectomy and 91% of them did not require any BT post-splenectomy. Among the patients treated conservatively 49% had persisting pallor and 16.3% had transfusion requirement. PMID:19490762

Kar, Rakhee; Rao, Seema; Srinivas, Upendra M; Mishra, Pravas; Pati, Hara P



Clinico-pathological correlations of fatty acid synthase expression in retinoblastoma: an Indian cohort study.  


Retinoblastoma (RB), the most common intra-ocular malignancy in children under 5 years of age, has an estimated incidence of about 2000 a year in India, where most cases are in advanced stage at the time of diagnosis. Newer therapeutic approaches would reduce the morbidity of chemotherapy in children with RB. Fatty Acid Synthase (FASN), a lipogenic multi-enzyme complex, is minimally expressed in normal human tissues and over expressed in many cancers, making it an attractive target for cancer therapy. We analyzed RB tissues for FASN protein expression by immunohistochemistry, western blot, and ELISA, and FASN mRNA expression by RT-PCR. FASN expression was correlated with the clinico-pathological characteristics of the tumors. FASN immunostaining was positive in all the 44 RB tissues analyzed (100%). However, FASN expression was heterogeneous within the tumor samples. Tumors with invasion of choroid, optic nerve, orbit and/or retinal pigment epithelium showed significantly higher FASN immunoreactivity than the tumors without invasion (P<0.05), supported by western analysis (P<0.05). FASN expression was significantly high in poorly differentiated retinoblastomas (P<0.05). FASN protein and FASN mRNA estimated by ELISA and RT-PCR respectively showed multi-fold expression over the non-neoplastic muller glial cells that varied quantitatively between tumor tissues. FASN mRNA over-expression was substantially lower than the corresponding FASN protein expression values. The present study reports (i) markedly high expression of FASN protein in poorly differentiated and in invasive retinoblastomas, and (ii) multi-fold over-expression of FASN mRNA and protein in RB tissues, although at varying levels, indicating FASN to be a potential therapeutic target in retinoblastoma management. PMID:21111730

Vandhana, S; Deepa, P R; Jayanthi, U; Biswas, J; Krishnakumar, S



Alzheimer's disease and the frontotemporal dementias: contributions to clinico-pathological studies, diagnosis, and cognitive neuroscience.  


This review focuses on six key papers published in the mid 2000 s based on work conducted in Cambridge. The first two relate to clinico-pathological studies which established that Alzheimer's disease (AD) is a relatively common cause of focal cortical syndromes, notably progressive aphasia (largely nonfluent), progressive apraxia, and posterior cortical atrophy with complex visual symptoms. Building on these findings, criteria for the progressive aphasias have been developed which define the variant associated with AD (progressive logopenic aphasia). Memory in the dementias has been a major area of interest and one paper discussed here explored the neural basis for episodic and semantic memory failure in AD and semantic dementia. Despite very different memory profiles, the two disorders both cause severe hippocampal hypometabolism and atrophy but differ in the degree of involvement of other memory related structures. This work drew attention to the role of pathology in non-hippocampal structures early in AD. The next two articles deal with the behavioral variant frontotemporal dementia (bvFTD) which we have shown is associated with breakdown in theory of mind, social reasoning, empathy, and emotion processing and contributed towork on the neural basis of social cognition. We also identified a subgroup of bvFTD who fail to progress over many years, termed phenocopy cases, who are differentiated by their lack of atrophy on MRI. The final paper described the application of the Addenbrooke's Cognitive Examination-Revised, which has proven a useful brief assessment tool for the early detection of a range of neurodegenerative disorders including AD and FTD. It also appears to be helpful in predicting those with mild cognitive impairment who will progress to frank dementia. PMID:22766737

Hodges, John R



Novel clinico-genome network modeling for revolutionizing genotype-phenotype-based personalized cancer care.  


Although cancer heterogeneity, even within individual tumors with different treatment responses of subcloncal cells populations, suggests the need for personalized medicine, most funding and efforts go to conventional single gene-based research and comparative-effectiveness research. Cancer arises from changes in the DNA sequence in the genomes of cancer cells. These accelerating somatic mutations dysregulate signaling pathways, including EGFR, Wnt/Notch, Hedgehog and others, with a central role in cell growth, proliferation, survival, angiogenesis and metastasis. All of these genetic alterations can now be discovered using next-generation DNA sequencing technology. This high-throughput technology can achieve two major goals: first, to complete the catalogue of driver mutations, including point mutations, rearrangements and copy-number changes, by full and targeted sequencing; and second, to explore the functional role of cancer genes and their interactions by genome-wide RNA, serial analysis of gene expression, microRNAs, protein-DNA interactions, and comprehensive analyses of transcriptomes and interactomes. This review article discusses the challenges, including costs, in completing the catalogue of driver mutations for each cancer type and understanding how cancer genomes operate as whole biological systems. Now high-quality clinical treatment and outcomes (death or survival) data from biobanks, and extensive genetics and genomics data for some common tumors, including breast, colorectal and pancreatic cancer, are available. In this article, we will describe how all these clinical and genetics data could be integrated into reverse engineering-based network modeling to approach the extremely complex genotype-phenotype map. This clinico-genome systems model, published for the first time, opens the way for the discovery of new molecular innovations, both predictive markers and therapies, towards personalized treatment of cancer. Instead of the comparative-effectiveness research or personalized medicine debate, harmonization of both can revolutionize cancer management. PMID:20014921

Roukos, Dimitrios H



Clinico-radiological and pathological evaluation of extra testicular scrotal lesions  

PubMed Central

Background: Scrotal ultrasound, though reliable in distinguishing between intratesticular and extratesticular lesions and characterizing them as cystic and solid, cannot distinguish benign from malignant pathology. Although fine needle aspiration cytology (FNAC) has proved to be of great diagnostic importance in testicular lesions, its scope in extratesticular lesions is largely unexplored. Aim: To evaluate extratesticular scrotal lesions cytologically and compare it with their clinical, radiological, and histological findings. Materials and Methods: Sixty five patients with extratesticular scrotal lesions were assessed clinically, radiologically, and cytologically. Histopathology was done in 45 cases where surgical exploration was undertaken. All the data were then analyzed and correlated. Results: Extratesticular lesions accounted for 72.2% of the scrotal swellings. Of these, the epididymis is most commonly involved (61.5% cases) with the commonest type of lesion being cystic (49.3% cases). Ultrasonography preferably with color doppler is highly useful for the evaluation of the scrotum. Apart from distinguishing extratesticular from testicular and cystic from solid lesions, it has an important role in identifying individual lesions, thus reducing the list of differential diagnosis. Fine needle aspiration cytology contributed to a definitive diagnosis in 47.7% cases. It helps classify cystic masses on the basis of their contents and defines the etiology of chronic inflammatory lesions, apart from corroborating with the clinico-radiological diagnosis. Histological evaluation was possible only in cases where surgery was performed and helps further define the diagnosis. Conclusion: Fine needle aspiration cytology is essentially non-traumatic and easy to carry out and should be a technique of choice for the study of scrotal pathology, main advantage being avoidance of delays in diagnosis.

Mukherjee, Suparna; Maheshwari, Veena; Khan, Roobina; Rizvi, Syed Amjad Ali; Alam, Kiran; Harris, Syed Hasan; Sharma, Rajeev



Fulminant pertussis: a multi-center study with new insights into the clinico-pathological mechanisms.  


Pertussis carries a high risk of mortality in very young infants. The mechanism of refractory cardio-respiratory failure is complex and not clearly delineated. We aimed to examine the clinico-pathological features and suggest how they may be related to outcome, by multi-center review of clinical records and post-mortem findings of 10 patients with fulminant pertussis (FP). All cases were less than 8 weeks of age, and required ventilation for worsening respiratory symptoms and inotropic support for severe hemodynamic compromise. All died or underwent extra corporeal membrane oxygenation (ECMO) within 1 week. All had increased leukocyte counts (from 54 to 132 x 10(9)/L) with prominent neutrophilia in 9/10. The post-mortem demonstrated necrotizing bronchitis and bronchiolitis with extensive areas of necrosis of the alveolar epithelium. Hyaline membranes were present in those cases with viral co-infection. Pulmonary blood vessels were filled with leukocytes without well-organized thrombi. Immunodepletion of the thymus, spleen, and lymph nodes was a common feature. Other organisms were isolated as follows; 2/10 cases Para influenza type 3, 2/10 Moraxella catarrhalis, 1/10 each with respiratory syncytial virus (RSV), a coliform organism, methicillin-resistant Staphylococcus aureus (MRSA), Haemophilus influenzae, Stenotrophomonas maltophilia, methicillin-sensitive Staphylococcus aureus (MSSA), and candida tropicalis. We postulate that severe hypoxemia and intractable cardiac failure may be due to the effects of pertussis toxin, necrotizing bronchiolitis, extensive damage to the alveolar epithelium, tenacious airway secretions, and possibly leukostasis with activation of the immunological cascade, all contributing to increased pulmonary vascular resistance. Cellular apoptosis appeared to underlay much of these changes. The secondary immuno-compromise may facilitate co-infection. PMID:19725100

Sawal, Mohammad; Cohen, Marta; Irazuzta, Jose E; Kumar, Ramani; Kirton, Christine; Brundler, Marie-Anne; Evans, Clair Anne; Wilson, John Andrew; Raffeeq, Parakkal; Azaz, Amer; Rotta, Alexandre T; Vora, Ajay; Vohra, Amit; Abboud, Patricia; Mirkin, L David; Cooper, Mehrengise; Dishop, Megan K; Graf, Jeanine M; Petros, Andy; Klonin, Hilary



Clinico-hematologic and serological comparison of Japanese and Russian strains of Theileria sergenti.  


The Japanese and Russian strains of Theileria sergenti were compared clinico-hematologically and serologically. They were subjected to passage in splenectomized calves 4 approximately 8 months old by the infectation of infected ticks or the inoculation of infected blood. As a result, the average of incubation of the Japanese strain was proved to be 23 days by the tick infection and 21 days by the inoculation of infected blood stored in a frozen state. The rate of detection and the average size of various forms of Theileria in the proliferative stage of the Japanese strain were as follows: Comma-shaped and bacilli forms, 86.8%; bacilli from 2.15 x 0.73 micron; oval and spherical forms, 11.3% and 1.97 x 1.22 and 1.46 micron, respectively; tetracoccal form and anaplasma-like form, 0.9 and 1.0%, respectively, and 0.54 micron in diameter. The highest parasitic rate of the Japanese strain was 11.9% on the average, and the rate of decrease in erythrocyte count 70.6% on the average. Rods were seen in protozoa particularly rich in cytoplasm. Such symptoms as pyrexia, depression, and anorexia appeared as Theileria propagated. No hemoglobinuria occurred or no schizonts were detected. Essentially the same results were obtained from the Russian strain as from the Japanese. Besides, Haemaphysalis longicornis produced in Japan acted also as a vector for the Russian strain. There was a good serological agreement between the Japanese and the russian strain in the results of the cross complement fixation test and the cross indirect fluorescent antibody test. There was no difference in the results of the complement fixation with the eight strains of the Japanese strain. PMID:6777702

Minami, T; Fujinaga, T; Furuya, K; Ishihara, T



Therapeutic and clinico-pathological factors in the survival of 1,469 patients with primary cutaneous malignant melanoma in clinical stage I  

Microsoft Academic Search

Therapeutic and clinico-pathological data of 1,469 patients with clinical stage I malignant melanoma of the skin without histological evidence of fibrotic areas of regression were examined by multivariate regression analysis. In accordance with a previous analysis anatomical site of tumour, tumour thickness, level of invasion, mitotic rate, ulceration, lymphhocytic reaction, dominant type of invasive tumour cell, and sex were found

Knud Søndergaard; Geert Schou



Clinico-morphological patterns of breast cancer including family history in a New Delhi hospital, India-A cross-sectional study  

Microsoft Academic Search

BACKGROUND: Breast cancer is the second most common malignancy among women, next to cervix cancer. Understanding its pathogenesis, morphological features and various risk-factors, including family history holds a great promise for the treatment, early detection and prevention of this cancer. PATIENTS AND METHODS: In an attempt to evaluate the clinico-morphological patterns of breast cancer patients, including their family history of

Sunita Saxena; Bharat Rekhi; Anju Bansal; Ashok Bagga; Chintamani; Nandagudi S Murthy



Motor neuron diseases in the university hospital of Fortaleza (Northeastern Brazil): a clinico-demographic analysis of 87 cases.  


In this retrospective (1980-1998) study, we have analyzed clinico-demographically, from the records of the University Hospital of Fortaleza (Brazil), a group of 87 patients showing signs and symptoms of motor neuron diseases (MNDs). Their diagnosis was determined clinically and laboratorially. The WFN criteria were used for amyotrophic lateral sclerosis (ALS) diagnosis. The clinico-demographic analysis of the 87 cases of MNDs showed that 4 were diagnosed as spinal muscular atrophy (SMA), 5 cases as ALS subsets: 2 as progressive bulbar paralysis (PBP), 2 as progressive muscular atrophy (PMA) and 1 as monomelic amyotrophy (MA), and 78 cases of ALS. The latter comprised 51 males and 27 females, with a mean age of 42.02 years. They were sub-divided into 4 groups according to age: from 15 to 29 years (n= 17), 30 to 39 years (n= 18), 40 to 69 years (n= 39) and 70 to 78 years (n= 4). From the 78 ALS patients, 76 were of the classic sporadic form whilst only 2 were of the familial form. The analysis of the 87 patients with MNDs from the University Hospital of Fortaleza showed a predominance of ALS patients, with a high number of cases of juvenile and early onset adult sporadic ALS. PMID:11105062

Castro-Costa, C M; Oriá, R B; Vale, O C; Arruda, J A; Horta, W G; D'Almeida, J A; Santos, T J; Ramos, R S; Gifoni, M A



L'errore nelle cure palliative secondo un'ottica costruttivista: presentazione di un caso clinico  

Microsoft Academic Search

Riassunto L'articolo nasce dall'esperienza personale di due operatori, una psicologa e un medico, che si occupano delle cure di fine vita. Nella nostra esperienza e confrontandoci con altri operatori, abbiamo più volte avvertito la difficoltà di conciliare la necessità di un approccio umanistico nella cura del malato con l'esigenza di rigore scientifico e metodologico. L'articolo tenta di dare una definizione


Para-clinico-pathological observations of insidious incidence of canine hepatozoonosis from a mongrel dog: a case report.  


A rare case of canine hepatozoonosis in a mongrel dog with para-clinico-pathological observations has been reported. The study included detailed haemato-biochemical changes at two stages, i.e. before treatment and after treatment with adopted therapy. Before therapy, blood picture revealed normocytic hypochromic anaemia and neutrophilic leucocytosis with variable counts of platelets. Thirty-seven percent of neutrophils were found infected with gametocytes of Hepatozoon canis. Following treatment, further decrease in haemoglobin value with a relative increase in lymphocyte count was seen. Biochemically, increase in alkaline phosphatase, blood urea nitrogen and creatinine levels along with hyperproteinemia was seen. The 14 days chemotherapy did not bring a respite for the dog and the level of parasitaemia was 33% after the treatment. The alkaline phosphatase and creatinine level further rose up following therapy with sulphadiazine and clindamycin. Continual study is required to explain the best possible therapeutic combination to deal H. canis. PMID:23543040

Kaur, Paramjit; Deshmukh, S; Singh, Rajsukhbir; Bansal, B K; Randhawa, C S; Singla, L D



Effects of Alzheimer's disease on the recognition of novel versus familiar words: neuropsychological and clinico-metabolic data.  


This study explored recognition memory performance for novel versus familiar words in Alzheimer's disease (AD) patients and normal controls (NCs), using an adaptation of E. Tulving and N. Kroll's (1995) procedure. Results showed that both groups exhibited more hits and more false alarms for familiar than for novel words. The groups did not differ in the recognition of familiar words, reflecting preserved familiarity processes in AD. However, AD patients made more false alarms than NCs in the recognition of novel words, reflecting impairment of recollection processes in AD. A positron emission tomography analysis of clinico-metabolic correlations in AD patients showed a correlation between recognition of novel words and right hippocampal activity, whereas recognition of familiar words was more related to metabolic activity in the left posterior orbitofrontal cortex. PMID:12597083

Lekeu, Françoise; Van der Linden, Martial; Degueldre, Christian; Lemaire, Christian; Luxen, André; Franck, Georges; Moonen, Gustave; Salmon, Eric



Clinico-demographic profile, sexual dysfunction and readiness to change in male alcohol dependence syndrome inpatients in a tertiary hospital.  


Persons with prolonged and heavy alcohol use generally suffer from alcohol dependence syndrome (ADS) and develop physical, sexual as well as psychiatric co-morbidity. Successful recovery to normalcy depends on multiple factors including patient's motivation. To study clinico-demographic profile, reasons for initiating alcohol use, sexual and psychiatric disorders and eagerness for treatment and quitting alcohol in ADS inpatients. Fifty consecutive ADS inpatients with matching controls were enrolled. Clinico-demographic profile, factors for initiating alcohol use, psychiatric and sexual co-morbidity and want for treatment and being abstinent was studied applying relevant scales. All subjects were males with a mean age of 37.5 years, 80% were married, majority were Hindu (88%) and from nuclear families (56%). Fifty two percent had an education level of Graduation or more and 68% of patients reported peer pressure to be the initiating factor for alcohol use. Seventy six percent had psychiatric co-morbidity including personality Problems and other Psychiatric disorders 19(38%), delirium tremens 14 (28.00%) and Mood disorders 12(24%).Depression being most common mood disorder (14%). Nicotine was the most common other substance of use 32 (64%). Sixty eight percent of the patient reported one or another sexual dysfunction. 68% of ADS inpatients acknowledged of having problems related to their drinking, expressed desire for change and were eager to avail treatment and to remain abstinent. ADS patients commonly suffer from psychiatric co-morbidity and sexual dysfunctions. They also wish to have effective treatment and to quit alcohol. PMID:23441492

Pandey, A K; Sapkota, N; Tambi, A; Shyangwa, P M



Spinal dural arterio-venous fistula: Clinico-radiological profile and outcome following surgical occlusion in an Indian neurosurgical center.  


Background: Spinal dural arteriovenous fistula (SDAVF) is a common type of spinal vascular lesion. However, there has not been any published study on its clinico-radiological characteristics or surgical outcome from India. Aim: The aim of this study was to determine the clinico-radiological features of patients with SDAVF, outcomes following surgical ligation of the fistula and the various factors involved. Materials and Methods: Patients who were operated for SDAVF were studied for demographic details, symptoms, clinical severity, radiological features and neurological outcome in the form of improvement in gait disability grades. Appropriate statistical tests were performed. Results: There were 22 (19 males, 3 females) patients of SDAVF who underwent surgical ligation with a mean age of 55 years. The mean duration of symptoms at presentation was 15 months. Three patients had acute onset while the rest had insidious onset of symptoms. Out of the 22 patients, 11 (50%) had motor weakness as the first symptom, 13 (59%) were bedridden and 19 (86.4%) had bladder involvement at presentation. Thirteen patients had fistulae in thoracic spine, whereas eight had fistulae in the lumbar spine. All had a favorable outcome in the form of at least non-progression of gait disability (14 had improvement while 8 had stabilized). The improvement was non-significantly associated with younger age, acute onset, ambulant status and fistula below T9. It was inversely associated with pain as the first symptom and fluctuant clinical course. Conclusion: Surgical occlusion of SDAVF is usually associated with either improvement or stabilization of motor weakness. PMID:24005733

Dhandapani, Sivashanmugam; Gupta, Aditya; Singh, Jasmeet; Sharma, B S; Mahapatra, A K; Mehta, V S


Anemia refrattaria con eccesso di blasti (AREB) in paziente con artrite reumatoide in trattamento con methotrexate ed infliximab: descrizione di un caso clinico Case report: AREB in a patient with rheumatoid arthritis treated with methotrexate and infliximab  

Microsoft Academic Search

SUMMARY Anti TNF-? drugs seem to be the new frontier of Rheumatoid Arthritis (RA) therapy. The association infliximab methotrexate has been approved for the treatment of RA not responding to the classic therapy, but the short clinical experience in using antiTNF-? molecules brings to segnalation of new risks or adverse events. We describe a case of a patient, treated for

Giuseppe D'Alessandro; Maria Rosaria Bianco; Spiridion Politis; Celestino Ferrandina; Giuseppe Rossi; Emanuele Altomare


An eight-year snapshot of geospatial cancer research (2002-2009): clinico-epidemiological and methodological findings and trends.  


Geographic information systems (GIS) offer a very rich toolbox of methods and technologies, and powerful research tools that extend far beyond the mere production of maps, making it possible to cross-link and study the complex interaction of disease data and factors originating from a wide range of disparate sources. Despite their potential indispensable role in cancer prevention and control programmes, GIS are underrepresented in specialised oncology literature. The latter has provided an impetus for the current review. The review provides an eight-year snapshot of geospatial cancer research in peer-reviewed literature (2002-2009), presenting the clinico-epidemiological and methodological findings and trends in the covered corpus (93 papers). The authors concluded that understanding the relationship between location and cancer/cancer care services can play a crucial role in disease control and prevention, and in better service planning, and appropriate resource utilisation. Nevertheless, there are still barriers that hinder the wide-scale adoption of GIS and related technologies in everyday oncology practice. PMID:20589539

Boulos, Dina N Kamel; Ghali, Ramy R; Ibrahim, Ezzeldin M; Boulos, Maged N Kamel; AbdelMalik, Philip



IGF-IR in patients with advanced colorectal cancer in correlation with certain clinico-morphological factors: Initial report  

PubMed Central

The insulin-like growth factor (IGF) system comprises two types of peptides (IGF-I and IGF-II), two types of receptors (IGF-IR and IGF-IIR) and six IGF-binding proteins (BP). This system is mainly responsible for the growth and division of cells in the body, regulation of the cell cycle and prevention of apoptosis. The expression of IGF-IR was assessed in the cells of resected primary colorectal tumours in 88 patients (age, 36-87 years; mean 64.78; males, 48 and females, 40) treated surgically at the Second Department of General and Gastroenterological Surgery, Medical University of Bialystok, Poland, in relation to various clinico-morphological factors. The post-operative material was analysed to find the histological type, location of lesions, lymph node involvement staging, distant metastases (pTNM classification), staging in Dukes’ classification and the histopathological differentiation grade. The expression of IGF-IR in colorectal cancer cells was assessed using an immunohistochemical method. The findings were subjected to statistical analysis (Chi-square test, multivariation test and Mann-Whitney U test). A positive IGF-IR expression (in at least 10% of cancer cells) was observed in 44 patients. The mean immunoreactive cell count for IGF-IR in all of the tumours studied was 30.79%. The current study showed no correlation of IGF-IR expression in colorectal cancer cells with characteristics such as age and gender of patients, tumour location, type, histological differentiation or histopathological advancement. Immunohistological determination of IGF-IR expression in advanced colorectal cancer cells revealed controversial scores. Evaluation should be confirmed by using other methods and enhanced to include adenomas and early colorectal cancers.




IGF-IR in patients with advanced colorectal cancer in correlation with certain clinico-morphological factors: Initial report.  


The insulin-like growth factor (IGF) system comprises two types of peptides (IGF-I and IGF-II), two types of receptors (IGF-IR and IGF-IIR) and six IGF-binding proteins (BP). This system is mainly responsible for the growth and division of cells in the body, regulation of the cell cycle and prevention of apoptosis. The expression of IGF-IR was assessed in the cells of resected primary colorectal tumours in 88 patients (age, 36-87 years; mean 64.78; males, 48 and females, 40) treated surgically at the Second Department of General and Gastroenterological Surgery, Medical University of Bialystok, Poland, in relation to various clinico-morphological factors. The post-operative material was analysed to find the histological type, location of lesions, lymph node involvement staging, distant metastases (pTNM classification), staging in Dukes' classification and the histopathological differentiation grade. The expression of IGF-IR in colorectal cancer cells was assessed using an immunohistochemical method. The findings were subjected to statistical analysis (Chi-square test, multivariation test and Mann-Whitney U test). A positive IGF-IR expression (in at least 10% of cancer cells) was observed in 44 patients. The mean immunoreactive cell count for IGF-IR in all of the tumours studied was 30.79%. The current study showed no correlation of IGF-IR expression in colorectal cancer cells with characteristics such as age and gender of patients, tumour location, type, histological differentiation or histopathological advancement. Immunohistological determination of IGF-IR expression in advanced colorectal cancer cells revealed controversial scores. Evaluation should be confirmed by using other methods and enhanced to include adenomas and early colorectal cancers. PMID:22848281

Kuklinski, Adam; Kamocki, Zbigniew; Koda, Mariusz; Piotrowski, Zdzislaw; Sulkowski, Stanislaw; Lesniewicz, Ryszard; Pawlak, Krystyna; Mysliwiec, Piotr; Kedra, Boguslaw



Clinico-pathological impact of cytogenetic subgroups in B-cell chronic lymphocytic leukemia: Experience from India.  


Background: The present study of 238 B-cell Chronic Lymphocytic Leukemia (B-CLL) patients were undertaken to seek the prevalence and to evaluate clinico-pathological significance of recurrent genetic abnormalities such as del(13q14.3), trisomy 12, del(11q22.3) (ATM), TP53 deletion, del(6q21) and IgH translocation/deletion. Materials and Methods: We applied interphase - fluorescence in situ hybridization (FISH) on total 238 cases of B-CLL. Results: Our study disclosed 69% of patients with genetic aberrations such as 13q deletion (63%), trisomy 12 (28%), 11q deletion (18%), 6q21 deletion (11%) with comparatively higher frequency of TP53 deletion (22%). Deletion 13q displayed as a most frequent sole abnormality. In group with coexistence of ?2 aberrations, 13q deletion was a major clone indicating del(13q) as a primary event followed by 11q deletion, TP53 deletion, trisomy 12, 6q deletion as secondary progressive events. In comparison with del(13q), trisomy 12, group with coexistence of ?2 aberrations associated with poor risk factors such as hyperleukocytosis, advanced stage, and multiple nodes involvement. In a separate study of 116 patients, analysis of IgH abnormalities revealed either partial deletion (24%) or translocation (5%) and were associated with del(13q), trisomy 12, TP53 and ATM deletion. Two of 7 cases had t(14;18), one case had t(8;14), and four cases had other variant IgH translocation t(?;14). Conclusion: Detail characterization and clinical impact are necessary to ensure that IgH translocation positive CLL is a distinct pathological entity. Our data suggests that CLL with various cytogenetic subsets, group with coexistence of ?2 aberrations seems to be a complex cytogenetic subset, needs more attention to understand biological significance and to seek clinical impact for better management of disease. PMID:24061469

Amare, Ps Kadam; Gadage, V; Jain, H; Nikalje, S; Manju, S; Mittal, N; Gujral, S; Nair, R


Nam Con Son Basin  

Microsoft Academic Search

The Nam Con Son basin is the largest oil and gas bearing basin in Vietnam, and has a number of producing fields. The history of studies in the basin can be divided into four periods: Pre-1975, 1976-1980, 1981-1989, and 1990-present. A number of oil companies have carried out geological and geophysical studies and conducted drilling activities in the basin. These

N. T. Tin; N. D. Ty; L. T. Hung



The Con Test  

ERIC Educational Resources Information Center

|In this article, the author describes the format of the Con Test, an Australian television game show which followed the same general rules and game play as the UK show PokerFace. At the end of each round a contestant needs to decide whether or not he or she should fold. A contestant needs to know how likely it is that he or she is in last place.…

Fletcher, Michael



MICrocephaly, disproportionate pontine and cerebellar hypoplasia syndrome: A clinico-radiologic phenotype linked to calcium/calmodulin-dependent serine protein kinase gene mutation.  


MICrocephaly, disproportionate pontine and cerebellar hypoplasia (MICPCH) syndrome, a rare X-linked disorder, generally seen in girls, is characterized by neurodevelopmental delay, microcephaly, and disproportionate pontine and cerebellar hypoplasia. It is caused by inactivating calcium/calmodulin-dependent serine protein kinase (CASK) gene mutations. We report a 2-year-old girl with severe neurodevelopmental delay, microcephaly, minimal pontine hypoplasia, cerebellar hypoplasia, and normal looking corpus callosum, with whom the conventional cytogenetic studies turned out to be normal, and an array-comparative genomic hybridization (a-CGH) analysis showed CASK gene duplication at Xp11.4. Our case highlights the importance of using clinico-radiologic phenotype to guide genetic investigation and it also confirms the role of a-CGH analysis in establishing the genetic diagnosis of MICPCH syndrome, when conventional cytogenetic studies are inconclusive. PMID:23901204

Saleem, Rashid; Setty, Gururaj; Hussain, Nahin



[Comparison of the results of clinico-epidemiological examination of retarded children-orphans and retarded children brought up in the family].  


A group of mentally retarded children (n = 881) aged 8 to 14 years, identified as a result of a clinico-epidemiological screening, were examined. The results obtained were compared in two groups. Group 1 (n = 272 or 30.9%) included orphans and children who remained without their parents' care since infancy and group II (n = 609 or 69.1%) included children brought up in complete or incomplete families. The differences were established in the degree of mental retardation, in its complication by additional psychopathological symptomatology, in the share of some complicating syndromes and the time of their origin, in the times of the diagnosis establishment and sending to specialized institutions, in the quality and timeliness of the assistance rendered, and in some other indicators. The importance of the problem of psychic deprivation in mental retardation is emphasized. PMID:1694380

Kryzhanovskaia, I L



Hepatocellular carcinoma in Native South Asian Pakistani population; trends, clinico-pathological characteristics & differences in viral marker negative & viral-hepatocellular carcinoma  

PubMed Central

Background HCC is the fifth most common cancer globally. Our study was conducted to (1)investigate the trends and clinico-pathological characteristics of Hepatocellular carcinoma among native South Asian patients in Pakistan, (2)to estimate the prevalence as well as the trends of viral marker negative HCC and (3) to compare the clinico-pathological, radiological characteristics, applicability of treatment at diagnosis and prognostic factors among patients with both viral marker negative and viral marker positive-HCC being consulted at Aga Khan University Hospital(AKUH), Karachi, Pakistan. Method Patients ?18 years, already diagnosed to have HCC and visiting AKUH during 1999–2009 were identified using ICD code 1550. The diagnosis of HCC was made in the presence of characteristic features of HCC on triple-phasic CT scan/MRI or with histological findings on biopsy. Results 645 patients were enrolled. Of these 546(84.7%) were viral-HCC and 99(15.3%) were viral marker negative HCC. Among viral-HCC group underlying etiology of cirrhosis was HCV in 67.9%, HBV in 21.8% and concomitant HBV with HCV or HDV in 10.3% cases. Majority (62.8%) patients had advanced HCC. Larger tumor size (p?



The clinico-pathological spectrum of Focal Cortical Dysplasias: a consensus classification proposed by an ad hoc Task Force of the ILAE Diagnostic Methods Commission  

PubMed Central

Focal cortical dysplasias (FCDs) are localized regions of malformed cerebral cortex and are very frequently associated with epilepsy in both children and adults. A broad spectrum of histopathology has been included in the diagnosis of FCD. Characteristic findings include aberrant radial or tangential lamination of the neocortex (FCD Type I) and cytological abnormalities (FCD Type II). An ILAE task force has re-evaluated available data and proposes a clinico-pathologic classification system of FCDs. The major change since a prior classification represents the introduction of FCD Type III, which occurs in combination with Hippocampal Sclerosis (FCD Type IIIa), or with epilepsy-associated tumors (FCD Type IIIb). FCD Type IIIc is found adjacent to vascular malformations, whereas FCD Type IIId can be diagnosed in association with epileptogenic lesions acquired in early life (i.e., traumatic injury, ischemic injury or encephalitis). Hence, FCD Type I will now refer to isolated lesions, which present either as radial (FCD Type Ia) or tangential (FCD Type Ib) dyslamination of the neocortex, microscopically identified in one or multiple lobes. FCD Type II is an isolated lesion characterized by cortical dyslamination and dysmorphic neurons without (Type IIa) or with balloon cells (Type IIb). Architectural abnormalities adjacent to or within gross malformations of cortical development are frequently observed and not distinguished as a specific FCD variant. This three-tiered classification system will help to better characterize specific clinico-pathological entities and is an important basis to further explore imaging, electro-clinical features, and postsurgical seizure control as well as underlying molecular pathomechanisms.

Blumcke, Ingmar; Thom, Maria; Aronica, Eleonora; Armstrong, Dawna D.; Vinters, Harry V.; Palmini, Andre; Jacques, Thomas S; Avanzini, Giuliano; Barkovich, A. James; Battaglia, Giorgio; Becker, Albert; Cepeda, Carlos; Cendes, Fernando; Colombo, Nadia; Crino, Peter; Cross, J. Helen; Delalande, Olivier; Dubeau, Francois; Duncan, John; Guerrini, Renzo; Kahane, Philippe; Mathern, Gary; Najm, Imad; Ozkara, Cigdem; Raybaud, Charles; Represa, Alfonso; Roper, Steven N.; Salamon, Noriko; Schulze-Bonhage, Andreas; Tassi, Laura; Vezzani, Annamaria; Spreafico, Roberto



A Study on Clinico-Mycological Profile, Aetiological Agents and Diagnosis of Onychomycosis at a Government Medical College Hospital in Kashmir  

PubMed Central

Background: Onychomycosis is a major public health problem with a high incidence, associated morbidity and a long lasting treatment with anti-fungal agents. This study was carried out to know the clinico-mycological pattern of onychomycosis, which could help in the control of this infection. Aims: The aim of this study was to determine the prevalence of various causative agents of onychomycosis and to study the clinical and mycological patterns of onychomycosis. Material and Methods: This was a prospective study which was carried over a period of one year, from 1st February 2011 to 31st January 2012 on samples from 150 patients with clinically suspected nail infections, who attended the Dermatology Department of SKIMS Medical college, Kashmir, India. The nails were evaluated clinically and the nail samples were subjected to direct microscopy and culture. Results: 60% samples were found to be positive by direct microscopy and culture. Males were infected more than females. The commonest age group which was infected was the 21-30 years age group. Finger nails were affected more frequently than toe nails and distolateral subungal onychomycosis was the most common clinical type of infection which was seen in 64.44% patients. The aetiological agents were dermatophytes (61.66%), Non–Dermatophyte Moulds (NDM) (31.66%) and yeasts (6.66%). Among dermatophytes, T. rubrum was the commonest aetiological agent. Conclusion: Although dermatophytes were the main causative agents, NDM and yeasts were also not uncommon aetiological agents of onychomycosis. This study also emphasized the need of performing both a direct examination and culture to improve sensitivity. Since onychomycosis can cause physical, psycological and occupational problems, the clinico-epidemiological data can be helpful in development of preventive and diagnostic strategies.

Lone, Rubeena; Bashir, Deeba; Ahmad, Shabir; Syed, Arshi; Khurshid, Syed




Center for Food Safety and Applied Nutrition (CFSAN)

Text Version... 160°F Pavo, Pollo 165°F CARNE FRESCAS DE RES, CERDO, TERNERA, CORDERO 145°F con 3 minutos de descanso CARNE DE AVE ... More results from


Clinico-biological characterization and outcome of primary nodal and extranodal diffuse large B-cell lymphoma in the rituximab era.  


To study the main clinico-biological characteristics and the outcome of patients with diffuse large B-cell lymphoma (DLBCL) according to the primary site (nodal vs. extranodal), we included 262 patients consecutively diagnosed with DLBCL in a single institution, 5 years before and after immunochemotherapy was considered as the standard treatment. Altogether 116 patients received CHOP (cyclophosphamide, adriamycin, vincristine, and prednisone) and 146 rituximab plus CHOP (R-CHOP). The primary site was the lymph node in 140 patients (53%), Waldeyer's ring (WR) in 22, gastrointestinal (GI) in 33, and other extranodal in 67. The addition of rituximab significantly improved the CR rate in nodal, but not in extranodal, lymphomas. Patients receiving R-CHOP showed higher OS than those treated with CHOP alone (5-year OS: 71% vs. 48%). This difference was maintained in primary nodal (5-year OS: 69% vs. 37%, p < 0.0001), but was not observed in primary extranodal (75% vs. 65%, p = 0.45) lymphomas. The IPI, treatment, and primary site were the main variables for OS in multivariate analysis. In nodal cases, IPI and treatment maintained value, whereas only IPI predicted OS in extranodal cases. In conclusion, immunochemotherapy treatment dramatically improved the outcome of patients with nodal DLBCL; however, its effect was less in primary extranodal cases, so the prognosis of patients with nodal and extranodal lymphomas has been equalized in the rituximab era. PMID:20497002

Gutiérrez-García, Gonzalo; Colomo, Lluis; Villamor, Neus; Arenillas, Leonor; Martínez, Antonio; Cardesa, Teresa; García-Herrera, Adriana; Setoain, Xavier; Rodríguez, Sonia; Ghita, Gabriela; Abrisqueta, Pau; Giné, Eva; Bosch, Francesc; Campo, Elías; Montserrat, Emilio; López-Guillermo, Armando



Clinico-pathological correlation and prognostic significance of nuclear p53 protein in colorectal cancer. Colorectal Cancer Study Group of the University and Health Care District of Modena.  


Overexpression of p53 protein was studied in neoplastic specimens of 150 patients registered for colorectal adenocarcinoma in the Health Care District 16 of Modena, Italy, from 1984 to 1986. We selected Dukes' stage B (92) and C (58) patients whose survival and recurrence rates are not easily predictable, with the purpose of defining subgroups of patients at high risk of recurrence. Monoclonal antibody PAb 1801 was used on formalin-fixed, paraffin embedded specimens. Nuclear staining was assessed to divide tumours into three groups: a) negative, b) low expressors, c) high expressors. Histomorphological variables of tumours, major clinical features of the patients and 5-year specific survival, were evaluated and related to p53 status. p53 was found in 71 out of 150 cases (47.3%); 50 tumours were high and 21 low expressors. No correlation was found between p53 overexpression and clinico-pathological variables. No difference in survival was found between patients with p53 positive and negative tumours in the entire series or within Dukes' stage B and C patients. However, the subgroup of patients with stage C rectal cancer seemed to have a better prognosis if the tumour was p53 negative (of borderline significance, p = 0.15). The same results were obtained by grouping low expressor tumours alternatively with negative or high expressors. We conclude that p53 nuclear overexpression does not seem to influence the prognosis of Dukes' stage B or C colorectal cancer patients. PMID:8842835

Fante, R; Di Gregorio, C; Losi, L; Roncucci, L; Ponz de Leon, M



Sub classification and clinico-hematological correlation of 40 cases of acute erythroleukemia - can proerythroblast/myeloblast and proerythroblast/total erythroid cell ratios help subclassify?  


The clinico-hematological profile of 40 cases of acute erythroleukemia (AEL) was evaluated. These were subclassified into three types, namely AML M6a, M6b and M6c based on the myeloblast and proerythroblast percentages. The proerythroblast percentage has been shown to be a prognostic indicator by several studies. As AEL is biologically an "erythroid predominant" disease, two ratios (PE/MB, PE/TEC) with proerythroblasts as numerator have been formulated. An attempt has been made to assess the difference in these ratios in subclassified AEL. There were 29 M6a, 2M6b,and 9 M6 c patients, which were subclassified using the criteria proposed by Mazzella et al. The incidence of AEL in our study was 3.7%, predominantly affecting males with a predilection to younger age in contrast to Western studies. Both PE/MB and PE/TEC ratios were higher in M6b and M6c in comparison to M6a. The subclassification of AEL becomes essential especially in the era of lineage-targeted therapies, which can lead to the development and use of erythroid specific treatments in the near future. PMID:17852448

Srinivas, Upendra; Kumar, Rajat; Pati, Hp; Saxena, Renu; Tyagi, Seema



Short-fragment PCR assay for highly sensitive broad-spectrum detection of human papillomaviruses in laryngeal squamous cell carcinoma and normal mucosa: clinico-pathological evaluation  

PubMed Central

The aim of the study was to determine the prevalence and genotypes of HPV infection in laryngeal cancer specimens, normal mucosa obtained from the surgical margin and laryngeal nodules using a novel high sensitive and specific SPF10 HPV DNA test, PCR/DEIA method and INNO-LiPA genotyping assay. The correlation between HPV presence and clinico-pathological features was analyzed. Tissue samples were collected from 93 primary laryngeal squamous cell carcinoma (LSCC), 49 specimens of normal mucosa and from 22 specimens of laryngeal nodules serving as control group. HPV DNA was amplified by the short PCR fragment (SPF10) primer set using HPV DNA enzyme immunoassay (DNA/DEIA) method and INNO-LiPA HPV genotyping assay. Human papillomavirus was detected in 33 (35.5%) of the 93 samples from LSCC, in 4 (8.2%) of 49 samples of the normal mucosa and it was not detected in any of the sample from the control group. Twenty-eight of 33 (81.8%) were positive for HPV-16, 6 of 33 (18.2%) were positive for HPV-18 and 5 of 33 (15.1%) were positive for HPV-33. Multiple infection was found in 5 of 33 (15.1%); 3 samples were positive for HPV-16 and HPV-33, 2 samples for HPV-16 and HPV-18. There was a statistically significant correlation between the presence of HPV in LSCC tumors and in control group samples and between the presence of HPV in the tumors and normal mucosa from the free surgical margin. The presence of HPV infection in 35.5% of the cases suggests a possible role in the etiology of laryngeal cancer and supports the role of high-risk types of HPV (16, 18 and 33) in LSCC. HPV infection is not likely to influence survival rates as an independent prognostic factor in patients with laryngeal cancer.

Polz-Dacewicz, Malgorzata; Szymanski, Marcin; Polz, Dorota



New proposed clinico-radiologic and molecular criteria in hypochondroplasia: FGFR 3 gene mutations are not the only cause of hypochondroplasia.  


We applied a comprehensive set of clinical and radiological criteria for the diagnosis of hypochondroplasia (HCH) in 160 patients with short stature 58 of whom were diagnosed to have HCH. Taking into account the genotypic and phenotypic variations in HCH, we conducted a study with these 58 patients and tested them for mutations in the fibroblast growth factor receptor 3 (FGFR3) and the short stature homeobox (SHOX) gene. We characterized the phenotypes by clinical and radiologic findings. In the patients with HCH, 19 were included in Group I (FGFR3 mutations-mutations of definite significance), and 39 were in Group II (6 SHOX mutations and 33 negative for disease-causing FGFR3 mutations). The clinical findings were similar in two groups regardless of the presence or absence of mutations. More than 95% of the patients had mesomelic proportions. In Group I, the radiological findings of mesomelia of upper and lower limbs and, L1/L4 ratio in anterior-posterior and lateral view were more typical than in Group II. This study proposes comprehensive clinico-radiological criteria for the diagnosis of HCH, which would help in detecting the true incidence of this underdiagnosed condition. The presence of SHOX mutations suggest genotypic-phenotypic overlap between HCH and Leri-Weill dyschondrosteosis, though further investigation is needed to effectively elucidate the importance of these mutations. Also, the 56.9% of HCH patients with negative mutations for FGFR3 suggests that there are other undiscovered gene mutations associated with this phenotypic entity. PMID:22903874

Song, Sang-Heon; Balce, Gracia Cielo Estrera; Agashe, Mandar Vikas; Lee, Hanna; Hong, Suk-Joo; Park, Young-Eun; Kim, Sang-Gyun; Song, Hae-Ryong



Hamartomas, teratomas and teratocarcinosarcomas of the head and neck: Report of 3 new cases with clinico-pathologic correlation, cytogenetic analysis, and review of the literature  

PubMed Central

Background Germ-cell tumors (GCT) are a histologically and biologically diverse group of neoplasms which primarily occur in the gonads but also develop at different extragonadal sites in the midline of the body. The head and neck region including the upper respiratory tract is a very rare location for such tumors in both children and adults, which can cause diagnostic and therapeutic difficulties. Methods We describe here two new cases of multilineage tumors including sinonasal teratocarcinosarcoma [SNTCS], and congenital oronasopharyngeal teratoma (epignathus) and compare their features with those of a new case of a rare salivary gland anlage tumor [SGAT], an entity for which the pathogenesis is unclear (i.e. hamartoma versus neoplasm). We correlate their presenting clinico-pathological features and compare histologic and cytogenetic features in an attempt to elucidate their pathogenesis and biologic potentials. Results and discussion Cytogenetic analysis revealed chromosomal abnormalities only in the case of SNTCS that showed trisomy 12 and 1p deletion. Both cytogenetic abnormalities are characteristically present in malignant germ cell tumors providing for the first time evidence that this rare tumor type indeed might represent a variant of a germ cell neoplasm. The SGAT and epignathus carried no such cytogenetic abnormalities, in keeping with their limited and benign biologic potential. Conclusion The comparison of these three cases should serve to emphasize the diversity of multilineage tumors (hamartomas and GCT) of the upper respiratory tract in regards to their biology, age of presentation and clinical outcomes. Malignant tumors of germ cell origins are more likely to affect adults with insidious symptom development, while benign tumors can nevertheless cause dramatic clinical symptoms which, under certain circumstances, can be fatal.

Vranic, Semir; Caughron, Samuel K; Djuricic, Slavisa; Bilalovic, Nurija; Zaman, Sadiq; Suljevic, Ismet; Lydiatt, William M; Emanuel, Jane; Gatalica, Zoran



Mixed exocrine-neuroendocrine carcinoma of the nasal cavity: clinico-pathologic and molecular study of a case and review of the literature.  


Sinonasal intestinal-type adenocarcinomas (ITACs) are rare neoplasms histologically resembling intestinal adenocarcinomas. Although a neuroendocrine differentiation in ITACs has been described, true mixed exocrine-neuroendocrine carcinomas, neoplasms in which each component represents at least 30 % of the lesion, are extremely rare and their molecular alterations are largely unknown. We describe herein the clinico-pathologic features, the methylation profile, chromosomal gains and losses, and mutation analysis of KRAS, BRAF and p53 in a nasal mixed exocrine-neuroendocrine carcinoma resected in a 79-year-old man. The tumor was composed of an ITAC and a poorly differentiated neuroendocrine carcinoma. Both exocrine and neuroendocrine components were CK8, CK20, CDX2 and p53 positive, and CK7 and TTF1 negative. The neuroendocrine component also showed immunoreactivity for chromogranin A, synaptophysin, serotonin and glicentin. Gains and losses were found at following chromosome regions: 17p13 (TP53), 14q24 (MLH3), 19q13 (KLK3), 5q21 (APC), 7q21 (CDK6), 9q34 (DAPK1), 12p13 (TNFRSF 1A, CDKN1B), 13q12 (BRCA2), 17p13.3 (HIC1), 18q21 (BCL2), and 22q12 (TIMP3). Aberrant methylation was detected only in the neuroendocrine component and involved APC and DAPK1 genes. No mutation of KRAS (exons 2-4), BRAF (exon 15), and p53 (exons 4-10) was found in both components. The results suggest a monoclonal origin of the tumor from a pluripotent cell undergoing a biphenotypic differentiation and that the neuroendocrine differentiation may be from an exocrine to an endocrine pathway. We have also reviewed the literature on sinonasal mixed exocrine-neuroendocrine carcinomas to give to the reader a comprehensive overview of these very rare tumor types. PMID:22740238

La Rosa, Stefano; Furlan, Daniela; Franzi, Francesca; Battaglia, Paolo; Frattini, Milo; Zanellato, Elena; Marando, Alessandro; Sahnane, Nora; Turri-Zanoni, Mario; Castelnuovo, Paolo; Capella, Carlo



Clinico-pathological findings in peripartum dairy cows fed anion salts lowering the dietary cation-anion difference: involvement of serum inorganic phosphorus, chloride and plasma estrogen concentrations in milk fever.  


In our previous study, it was demonstrated that the administration of anion salts, which slightly lower the dietary cation-anion difference (DCAD), in the prepartum period is safe and effective for preventing milk fever in multiparous cows. In the present study, several clinico-pathological constituents in serum and urine, which might be related to milk fever, were analyzed using stored samples from the previous study to identify clinico-pathological parameters for easily evaluating the efficacy of lowering DCAD and to further investigate the mechanism by which lowering DCAD prevents milk fever. Among the parameters analyzed in the present study, inorganic phosphorus (iP) was involved in milk fever because the serum concentration and urinary excretion of iP were significantly higher in the group of primiparous cows (heifer group), which did not develop hypocalcemia, than those in other groups of multiparous cows. Serum chloride concentrations in the heifer group and the group of multiparous cows fed anion salts (anion group) tended to remain higher than those in other control groups of multiparous cows suggesting that serum chloride concentration may be utilized for evaluating the status of metabolic acidosis and the efficacy of lowerng DCAD in dairy cows fed anion salts. In addition, plasma estradiol-17beta concentration in the heifer group tended to be lower at parturition compared with that in other multiparous groups suggesting that estrogen known as a potent inhibitor of bone resorption may be involved in developing milk fever. PMID:17596033

Kurosaki, Naotoshi; Yamato, Osamu; Sasamoto, Yoshihiko; Mori, Fuminobu; Imoto, Seiichi; Kojima, Toshiyuki; Yamasaki, Masahiro; Maede, Yoshimitsu



Synthetic slings: pros and cons.  


Historically, the choice of sling material for the treatment of urinary incontinence has been based on the surgeon's preference and experience. In general, pelvic surgeons have not differentiated artificial graft materials by their inherent qualities or for biocompatibility in the female pelvis and vaginal wall. The introduction of new artificial graft materials and new methods of implantation for the correction of genuine stress incontinence has generated renewed interest in the "pros and cons" associated with nonabsorbable material use. In this review, we discuss and differentiate sling materials and techniques. We consider some of the physical and biologic qualities of artificial graft materials, present theories and practices associated with the successful use of permanent grafts, and discuss the natural evolution of artificial graft slings to the current use of the tension-free vaginal tape and Suprapubic Arc Sling System (American Medical Systems, Minneapolis, MN). PMID:12354353

Staskin, David R; Plzak, Louis



¡Truco Con Agua!  

NSDL National Science Digital Library

En esta actividad los aprendices aprenderán un truco de magia donde la magia es la presión del aire. Los participantes tomarán un vaso de agua medio lleno y lo taparán con un pedazo de plástico o cartón. Sosteniendo la tarjeta contra el vaso, lo voltearán boca abajo y cuando quiten la mano debajo del vaso, ¡abracadabra! no se caerá el agua. En la tira cómica, Mateo explica a los aprendices que la presión que hace el aire en todas las direcciones es la que sostiene la tarjeta.

Science, Lawrence H.



Genetic polymorphism of CON 1 and CON 2 salivary proteins detected by immunologic and concanavalin a reactions on nitrocellulose with linkage of CON 1 and CON 2 genes to the SPC (salivary protein gene complex)  

Microsoft Academic Search

Two new genetic protein polymorphisms (CON 1 and CON 2) were identified in parotid saliva. Genetic polymorphisms of salivary CON 1 (concanavalin A) and CON 2 proteins are determined by autosomal inheritance of one expressed (dominant) and one unexpressed (recessive) allele for each gene. Autosomal inheritance is supported by studies in 26 families including 105 children for CON 1 and

Edwin A. Azen; Pao-Lo Yu



Automedicarse con antibióticos puede perjudicar su salud  

Center for Drug Evaluation (CDER)

... Automedicarse con antibióticos puede perjudicar su salud. (poster). ... Consulte a su médico oa un profesional de la salud antes de usar antibióticos. ... More results from


Automedicarse con antibióticos puede perjudicar su salud ...  

Center for Drug Evaluation (CDER)

... Automedicarse con antibióticos puede perjudicar su salud (PSA). ... Consulte a su médico oa un profesional de la salud antes de usar antibióticos. ... More results from


The Pros and Cons of Artificial Reefs  

NSDL National Science Digital Library

This lesson plan asks students to consider whether artificial reefs (human-made objects in the ocean or sea) are good for marine ecosystems. Students will look at pictures of artificial reefs and read articles describing the pros and cons of these structures. They will conclude by writing paragraphs explaining whether they think a new artificial reef should be created in Florida waters.


The pros and cons of hospital employment.  


The pros and cons of hospital employment vary significantly in today's economic environment. This chapter summarizes the advantages and disadvantages of hospital employment with an emphasis on the critical aspect of formalizing an agreement with the hospital employer to prevent future salary reductions and/or termination. PMID:23924751

Bert, Jack M



Google Scholar: the pros and the cons  

Microsoft Academic Search

Purpose – To identify the pros and the cons of Google Scholar. Design\\/methodology\\/approach – Chronicles the recent history of the Google Scholar search engine from its inception in November 2004 and critiques it with regard to its merits and demerits. Findings – Feels that there are massive content omissions presently but that, with future changes in its structure, Google Scholar

Péter Jacsó



InterCon Travel Health: Case B  

ERIC Educational Resources Information Center

|InterCon provides services to health insurers of foreign tourists who travel to the United States and Canada. Management wants to implement a new information system that will deal with several operational problems, but it is having difficulty securing the capital resources to fund the system's development. After an initial failure, the chief…

Truman, Gregory E.; Pachamanova, Dessislava A.; Goldstein, Michael A.



InterCon Travel Health: Case B  

ERIC Educational Resources Information Center

InterCon provides services to health insurers of foreign tourists who travel to the United States and Canada. Management wants to implement a new information system that will deal with several operational problems, but it is having difficulty securing the capital resources to fund the system's development. After an initial failure, the chief…

Truman, Gregory E.; Pachamanova, Dessislava A.; Goldstein, Michael A.



Somatic cell nuclear transfer: pros and cons.  


Even though the technique of mammalian SCNT is just over a decade old it has already resulted in numerous significant advances. Despite the recent advances in the reprogramming field, SCNT remains the bench-mark for the generation of both genetically unmodified autologous pluripotent stem cells for transplantation and for the production of cloned animals. In this review we will discuss the pros and cons of SCNT, drawing comparisons with other reprogramming methods. PMID:20232594

Sumer, Huseyin; Liu, Jun; Tat, Pollyanna; Heffernan, Corey; Jones, Karen L; Verma, Paul J




Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey



9 CFR 319.301 - Chili con carne with beans.  

Code of Federal Regulations, 2010 CFR

... 2010-01-01 2010-01-01 false Chili con carne with beans. 319.301 Section 319.301...Dehydrated Meat Food Products § 319.301 Chili con carne with beans. Chili con carne with beans shall contain not less...



9 CFR 319.301 - Chili con carne with beans.  

Code of Federal Regulations, 2010 CFR

... 2009-01-01 2009-01-01 false Chili con carne with beans. 319.301 Section 319.301...Dehydrated Meat Food Products § 319.301 Chili con carne with beans. Chili con carne with beans shall contain not less...



Jugando con geometría: Crear secuencias con formas y palabras  

NSDL National Science Digital Library

En esta actividad, los chicos crean secuencias con palabras y formas. Los chicos usan colecciones de triángulos, cuadrados, y rectángulos con palabras adentro. Los chicos organizan las forman en secuencias geométricas que se repiten o que cambian de manera sistemática en cada línea. Los chicos más jóvenes pueden crear secuencias simples; los mayores pueden explorar secuencias que crecen de diferentes maneras. Esta actividad tiene colecciones de palabras en tres niveles de dificultad diferente. Disponible en formato Web y PDF. También disponible en Inglés.




Identification of resistance of Plasmodium falciparum to artesunate-mefloquine combination in an area along the Thai-Myanmar border: integration of clinico-parasitological response, systemic drug exposure, and in vitro parasite sensitivity  

PubMed Central

Background A markedly high failure rate of three-day artesunate-mefloquine was observed in the area along the Thai-Myanmar border. Methods Identification of Plasmodium falciparum isolates with intrinsic resistance to each component of the artesunate-mefloquine combination was analysed with integrated information on clinico-parasitological response, together with systemic drug exposure (area under blood/plasma concentration-time curves (AUC)) of dihydroartemisinin and mefloquine, and in vitro sensitivity of P. falciparum in a total of 17 out of 29 P. falciparum isolates from patients with acute uncomplicated falciparum malaria. Analysis of the contribution of in vitro parasite sensitivity and systemic drug exposure and relationship with pfmdr1 copy number in the group with sensitive response was performed in 21 of 69 cases. Results Identification of resistance and/or reduced intrinsic parasitocidal activity of artesunate and/or mefloquine without pharmacokinetic or other host-related factors were confirmed in six cases: one with reduced sensitivity to artesunate alone, two with resistance to mefloquine alone, and three with reduced sensitivity to artesunate combined with resistance to mefloquine. Resistance and/or reduced intrinsic parasitocidal activity of mefloquine/artesunate, together with contribution of pharmacokinetic factor of mefloquine and/or artesunate were identified in seven cases: two with resistance to mefloquine alone, and five with resistance to mefloquine combined with reduced sensitivity to artesunate. Pharmacokinetic factor alone contributed to recrudescence in three cases, all of which had inadequate whole blood mefloquine levels (AUC0-7days). Other host-related factors contributed to recrudescence in one case. Amplification of pfmdr1 (increasing of pfmdr1 copy number) is a related molecular marker of artesunate-mefloquine resistance and seems to be a suitable molecular marker to predict occurrence of recrudescence. Conclusions Despite the evidence of a low level of a decline in sensitivity of P. falciparum isolates to artemisinins in areas along the Thai-Myanmar border, artemisinin-based combination therapy (ACT) would be expected to remain the key anti-malarial drug for treatment of multidrug resistance P. falciparum. Continued monitoring and active surveillance of clinical efficacy of ACT, including identification of true artemisinin resistant parasites, is required for appropriate implementation of malaria control policy in this area.



Pros and cons of phage therapy  

PubMed Central

Many publications list advantages and disadvantages associated with phage therapy, which is the use of bacterial viruses to combat populations of nuisance or pathogenic bacteria. The goal of this commentary is to discuss many of those issues in a single location. In terms of “Pros,” for example, phages can be bactericidal, can increase in number over the course of treatment, tend to only minimally disrupt normal flora, are equally effective against antibiotic-sensitive and antibiotic-resistant bacteria, often are easily discovered, seem to be capable of disrupting bacterial biofilms, and can have low inherent toxicities. In addition to these assets, we consider aspects of phage therapy that can contribute to its safety, economics, or convenience, but in ways that are perhaps less essential to the phage potential to combat bacteria. For example, autonomous phage transfer between animals during veterinary application could provide convenience or economic advantages by decreasing the need for repeated phage application, but is not necessarily crucial to therapeutic success. We also consider possible disadvantages to phage use as antibacterial agents. These “Cons,” however, tend to be relatively minor.

Loc-Carrillo, Catherine



The 2009 Astrobiology Graduate Student Conference (AbGradCon)  

NASA Astrophysics Data System (ADS)

The 2009 AbGradCon was held at the University of Washington in July 2009. It brought together 67 participants from 8 different countries and 34 different universities. AbGradCon also took place in the virtual world of Second Life.

Som, S. M.; Anderson, R.; Antonio, M.; Cash, M. C.; Claire, M.; Cowan, N.; Ewert, M.; Goldman, A.; Snowden, D.; Stüeken, E.



A ConA-like lectin from Dioclea guianensis Benth. has antifungal activity against Colletotrichum gloeosporioides, unlike its homologues, ConM and ConA.  


This study reports on the antifungal activity of Dgui, a ConA-like lectin from Dioclea guianensis seeds. Dgui inhibited conidial germination but not mycelial growth of Colletotrichum gloeosporioides. The lectins ConA and ConM from Canavalia ensiformis and Canavalia maritima, respectively, share high levels of amino acid sequence similarity (>84%) with Dgui and have the same specificity toward glucose/mannose but had no effect on the fungus. Fluorescence microscopy showed that both Dgui and ConM bind to C. gloeosporioides ungerminated conidia. However, Dgui did not bind to C. gloeosporioides germinated conidia and germ tubes and was not inhibitory to mycelial growth. Because only Dgui inhibited germination of the fungus, C. gloeosporioides conidia might have surface-specific germination targets recognized by Dgui but not by its homologues, ConM and ConA. Therefore, Dgui is a candidate for biotechnological approaches for improving the resistance of various nutritionally and commercially important crops that are affected by C. gloeosporioides. PMID:20201549

Araújo-Filho, José H; Vasconcelos, Ilka M; Martins-Miranda, Aparecida S; Gondim, Darcy M F; Oliveira, José T A



Cálculos ab initio con correlación electrónica  

NASA Astrophysics Data System (ADS)

Estamos entrando en una era donde la ortogonalidad entre las investigaciones de carácter experimental y de naturaleza teórica se irá difuminando progresivamente y la problemática a resolver quedará en escena como el único actor principal de la obra. Como premisa para una cooperación teórico-experimental de igual a igual, la metodología químico-cuántica utilizada debe ser capaz de ofrecer resultados de carácter predictivo. Sin duda, esta madurez en la metodología químico-cuántica ya la hemos alcanzado hace algunos años, tal y como muestra entre otras muchas, la labor que nuestro grupo ha realizado en el transcurso de la última década, dentro del campo de la Espectroscopía Teórica. Los estudios realizados comprenden una amplia gama de sistemas, variando tanto en tamaño como en complejidad, abordando problemáticas espectroscópicas consideradas tradicionalmente como especialmente controvertidas. Nuestra contribución científica más relevante reside en el carácter cuantitativo de las asignaciones espectroscópicas que hemos propuesto en base a resultados ab initio. Recordemos que en los años noventa los resultados ab initio solían presentar para las energías de excitación de sistemas de tamaño molecular moderado, como el benceno, errores de más de 1 eV. En comparación con el éxito relativo de los métodos semiempíricos, la frustración de la metodología ab initio quedaba todavía más patente. Los estudios que hemos presentado representan una comprensión profunda de los espectros electrónicos en sistemas orgánicos claves, mostrando el camino a seguir para obtener asignaciones espectroscópicas precisas (entre 0.1-0.2 eV). La naturaleza del método CASPT2 junto al diseño de estrategias computacionales nos ha permitido alcanzar el carácter cuantitativo con el que se caracterizan nuestras contribuciones[1,2]. Por todo ello, algunos de los trabajos publicados se consideran clásicos dentro del campo, pues en cierto modo definen el campo, y se reflejan en libros publicados recientemente. En la conferencia se analizarán ciertos pormenores de las investigaciones realizadas. El tipo de aplicaciones llevadas a cabo hasta la fecha se ilustrará mediante el estudio teórico del espectro electrónico de ciclooctatetraeno. Dando un paso más en la evolución de nuestra investigación, pretendemos en la actualidad describir, desde un formalismo teórico y al mismo nivel de exigencia, los mecanismos subyacentes que tienen lugar en las reacciones biológicas fototoinducidas, es decir, reacciones que se inician mediante la absorción de luz[3]. Como muestra de la caracterización de los procesos fotofísicos y fotoquímicos en fotobiología teórica, hemos elegido la descripción de la conversión interna ultrarrápida que tiene lugar en los cromóforos del ADN. Los estados excitados de las moléculas de los ácidos nucleicos presentan tiempos de vida media que se encuentran en el rango de sub-picosegundos, sugiriendo la presencia de un canal ultrarrápido de conversión interna, lo que normalmente se asocia en la fotoquímica contemporánea a una intersección cónica entre el estado excitado y el fundamental[4]. De esta forma nuestro ADN previene de forma eficaz posibles reacciones en el estado excitado y se revela como un excelente protector solar.

Merchán Bonete, M.


Pro/con a precessional geodynamo  

NASA Astrophysics Data System (ADS)

The modest amount of research that exists on the ability, or lack of ability, of mantle precession to power a geodynamo developed mostly during the last half of the 1900s. Papers by Roberts and Stewartson (1965) and by Busse (1968) studied precession generally without a pro/con conclusion. Malkus in the late 1960s attempted to advance a positive role for precession through experiments and analysis. His experiments have survived criticism, but his analyses were discounted, especially by Rochester, Jacobs, Smylie, and Chong (1975) and by Loper (1975). Rochester, et al. critiqued existing analyses of precession, including those of Malkus, but did not reach a strong position either pro or con a precessional geodynamo. Loper argued emphatically that precession was not capable of powering the geodynamo. Explicit analyses that either critique or support Loper’s arguments have yet to appear in the literature. During the 1970s, Vanyo and associates studied energy dissipation during precession of satellite liquid fuels and its effect on satellite attitude stability. Engineers and scientists in every country that has launched satellites completed similar research. Some is published in the aerospace literature, more is available in company and government reports. Beginning in 1981, Vanyo and associates applied this knowledge to the very similar problem of energy dissipation and flow patterns in precessing mechanical models scaled geometrically and dynamically to the Earth’s liquid core. Energy experiments indicate massive amounts of mechanical energy are dissipated at the CMB, and flow experiments show complex motions within the boundary layer and axial flows with helicity throughout the interior. Analysis of Earth core precession also advanced, especially in several papers by Kerswell and by Tilgner in the late 1990s. Detail numerical models have yet to appear. Although progress in understanding the role of precession in Earth core motions has advanced, there remains a common belief, often expressed explicitly, that precession is incapable of energizing a geodynamo, a la Loper. We will present a critique of Loper’s 1975 paper and briefly discuss the common practice and belief that the geodynamo must be energized by thermal and/or compositional driven convection (motion). We note here that there is no observational evidence for existence of thermal or compositional convection within the liquid core or for growth of the solid core. Although there has been considerable success in adapting data in thermal/compositional models to yield near realistic solutions, that does not constitute a proof that those models apply to the Earth. There is absolute observational evidence for mantle precession, an Earth feature that is unique, along with the Earth’s magnetic field, among the terrestrial planets. We argue that great difficulty experienced in analysis and computation of precessional flow is a major explanation for its absence in current models of the geodynamo.

Vanyo, J.



[Mesenchymal chondrosarcoma (clinico-morphological study)].  


Mesenchymal chondrosarcoma was found in 11 out of 161 patients with chondrosarcoma of the bone. The assaultive nature of the disease is illustrated by the following data: the period between the manifestation of symptoms and the first visit to the doctor was 5.9 +/- 4.3 months; metastases were detected within 20.56 +/- 6.04 months and 8 patients out of 10 died within the first 5 years. Two histological structures were observed: those of the chondrosarcoma type and hemangiopericytoma-like structures formed of small atypical cells. PMID:6636625

Solov'ev, Iu N; Eremina, L A; Petrovichev, N N; Khmelev, O N; Kasumov, I V



Clinico-pathological study on denture stomatitis.  


The clinical and pathological study was performed in order to determine the histopathological and cytoimmunological characteristics of denture stomatitis. All specimens were biopsy materials from seventeen patients with denture stomatitis. Normal palatal mucosae from ten patients served as the control. In addition to the usual staining methods, naphtol AS-D chloroacetate esterase stain and peroxidase-antiperoxidase method were used to detect mast cells and plasma cells. Denture stomatitis could be divided into atrophic and hyperplastic types. The former showed a smooth and atrophic mucosa. The latter showed a large number of exophytic projections which were composed of marked acanthosis and submucosal fibrosis, and was further subdivided into granular and papillary subtype according to the size of projections. In the present study, there were six cases of the atrophic type, and eleven cases of the hyperplastic type (consisting of seven granular and four papillary subtypes). The hyperplastic type was more frequently observed in patients with partial dentures compared with complete dentures and was associated frequently with ill fitting of the denture base as well as agglutination of denture plaque. Cytoimmunological study revealed that there was a pronounced increase of plasma cells, especially IgG- and IgA-producing cells, and a moderate increase of lymphocytes as well as mast cells in both types of denture stomatitis. Mast cells were always noted in the area with marked plasma cell infiltration, suggesting an intimate relation between both cells. These findings suggest that the immunological reactions play some role in the pathogenesis of denture stomatitis. PMID:3481390

Morimoto, K; Kihara, A; Suetsugu, T



Joubert syndrome: a clinico-radiological study  

Microsoft Academic Search

A characteristic malformation of the cerebellum, including dysgenesis of the vermis and enlargement of the fourth ventricle was observed on computed tomography (CT) in 16 children on review of our consecutive material. Seven of these children underwent magnetic resonance imaging (MRI) which showed hypoplasia of the brainstem in addition to cerebellar vermian dysgenesis. One child had, in addition, dysgenesis of

B. Kendall; D. Kingsley; S. R. Lambert; D. Taylor; P. Finn



[Experimental dermatomycosis, a clinico-pathological study].  


Using rabbits, we have studied the effect of reinfection of T. mentagrophytes var granulosum and T. rubrum into lesions that were previously infected and resolved. Clinical mycological and histopathological studies were done for 16 weeks. Timentagrophytes produced a more severe infection than T. rubrum. The clinical lesions produced by reinoculation were less intense and long lasting. PMID:7322193

García de Lomas, J; Rodriguez, F; Ortega, V; Cavas, M L; Altuna, A



[Reflux esophagitis: clinico-endoscopic aspects].  


Though long well known, reflux oesophagitis is as yet poorly understood in terms of both incidence and physiopathology. These aspects of gastrooesophageal reflux were studied in a group of patients subjected to endoscopic examination. The 13.6% incidence of the condition was very similar to the encountered incidence of ulcers. In two thirds of the cases, anamnesis is sufficient for correct diagnosis. In its more severe forms, reflux oesophagitis is associated with hiatus hernia and overindulgence in tobacco or alcohol. Routine radiology is practically or completely useless for the diagnosis of reflux oesophagitis. The use of the Savary classification system facilitates endoscopic diagnosis and staging. PMID:4047453

Maraschin, B; Ronzani, G; Calcaterra, F



Television and Children: A Pro/Con Reading List.  

ERIC Educational Resources Information Center

Lists books, audiovisual materials, newspaper articles, pamphlets, government documents, and periodical articles on the effects of television on children. Divided into sections on pro and con sources, the 53 annotated items are arranged by type of material. (BK)

Erbeck, Diane M.



Compositional Quality Control Study of CON-2 Glass.  

National Technical Information Service (NTIS)

A statiscal strategy was used to select experiments to determine how commonly measured physical properties of CON-2 glass vary with composition. The physical properties explored in the study included density, dilatometric softening temperature, thermal ex...

C. Nelson E. V. Thomas P. R. Wengert



Breath analysis science at PittCon 2012, Orlando, Florida  

Microsoft Academic Search

BackgroundBreath analysis science was featured in three organized sessions at this year's Pittsburgh Conference and Exposition, or 'PittCon 2012' (http:\\/\\/\\/). As described in previous meeting reports, PittCon is one of the largest international conferences for analytical chemistry and instrumentation, typically attracting about 20 000 attendees and 1000 commercial exhibitors (Pleil 2010, 2011). This year the conference was held in Orlando,

Joachim D Pleil; Matthew A Stiegel; Tzipporah M Kormos; Jon R Sobus



Paramagnetic-to-Ferromagnetic Transition in Con Under Pressure  

NASA Astrophysics Data System (ADS)

Motivated by reports of synthesis of zincblende (ZB) structure CrAs in thin film form, strong interest has developed in understanding transition metal pnictides and their tendencies toward magnetic order.Literature on the experimental analysis of the structure of CoN is varied, with reports of both magnetically ordered NaCl structure CoN and non-magnetic ZB CoN. We present results of first principles analysis of electronic structure, magnetism and Murnaghan equation of state for both structures. The non-magnetic ZB structure, stable at ambient pressure transforms to a collapsed ferromagnetic NaCl phase at 10GPa (?V = -15%). These results will be compared to data and similarities/differences with other transition metal nitrides will be discussed.

Kasinathan, Deepa; Pickett, Warren



La fotoscintigrafia con Hg 203 e Tc 99 nella diagnosi delle lesioni cerebrali  

Microsoft Academic Search

Riassunto Gli AA presentano i risultati ottenuti con la fotoscintigrafia con Hg203 e Tc99 in 244 casi. Dopo aver osservato l'elevata positività con cui vengono diagnosticati i tumori cerebrali (64 casi su 65), gli autori considerano come sia più difficile con la scintigrafia rispetto alla gammaencefalografia porre una diagnosi di natura del tumore. I risultati positivi ottenuti nelle lesioni espansive

A. Agnoli; C. Fieschi; L. Bozzao; A. Bartolini



Investigación Estudio sistematizado de familias con adolescentes y estilos de vida saludable  

Microsoft Academic Search

Al sistematizar la experiencia realizada junto a fami- lias con adolescentes, para construir con esta población estilos de vida saludable que favorecieran el crecimiento y desarrollo de los y las adolescentes, se relacionaron los procesos inmediatos y el quehacer con su contexto; a la vez, se confrontó dicho quehacer con los supuestos teóricos que los inspiraron. Se sustentó la experiencia


Caracterización de tintas de titanio dopadas con óxidos metálicos  

Microsoft Academic Search

Se prepararon tintas de Diisopropoxido de titanio bis(acetilacetonato) por el método sol-gel para aplicar en la elaboración de nanoestructuras mediante la técnica de escritura directa. Esta técnica permite estructurar materiales con alto índice de refracción a escala micro y nanométrica en tres dimensiones mediante extrusión, para elaborar cristales fotónicos. El tratamiento de las nanoestructuras extruidas a temperaturas elevadas para transformarlas



Exact Solutions of Diusion-Con vection Equations  

Microsoft Academic Search

In the presented paper known (up to the beginning of 2008) Lie- and non-Lie exact solutions of dieren t (1+1)-dimensional diusion{con vection equations of form f(x)ut = (g(x)A(u)ux)x + h(x)B(u)ux are collected.

Nataliya M. Ivanova



Pros and Cons of Part-Time Faculty.  

ERIC Educational Resources Information Center

A study of the pros and cons of part-time faculty shows that about one-third of all college faculty are part-time. They cost less, and are a valuable asset to a school, but may cause accrediting problems if they number more than 25 percent of the total faculty. (JMF)

AGB Reports, 1979



Desarrollo y transferencia tecnológica de pastas funcionales extendidas con leguminosas  

Microsoft Academic Search

RESUMEN. La pasta de sémola es un alimento altamente consumido, cuyo valor biológico es bajo porque su proteína es deficiente en lisina. Sin embargo, si se extiende la sémola con leguminosas ricas en este aminoácido esencial, no sólo se produce una complementación aminoacídica, sino que se incrementa el contenido de fibra dietética y de minerales. En este trabajo se produjeron

Marisela Granito; Vanesa Ascanio


Reputation, Social Identity and Social Con‡ict  

Microsoft Academic Search

We interpret the psychology literature on social identity and examine its implications in a population partially composed of such agents. We model a population of agents from two exogenous and well de…ned social groups. Agents are randomly matched to play a reduced form bargaining game. We show that this struggle for resources drives a con‡ict through the rational destruction of

John Smithy


SatisfacciÛn marital en pacientes con artritis reumatoide. Estudio comparativo con otras enfermedades crÛnicas y controles sanos  

Microsoft Academic Search

SUMMARY Objective: to assess marital satisfaction (MS) in patients with rheumatoid arthritis (RA) and com- pare it with other chronic diseases and normal con- trols. Material and methods: we studied 50 patients with RA and compared them with 50 patients with systemic lupus erythematosus (SLE), 50 patients with diabetes mellitus (type 2), and 50 normal controls. We applied a marital

Barile Fabris


The king of Comic-Con [Geek life  

Microsoft Academic Search

The last thing you want to do is rankle a group of Star Wars stormtroopers. The annual geekfest known as Comic-Con International is not only a four-day exploration of the intersection of science fiction, comics, science, and pop culture; with 125,000 attendees, it's one of the largest conventions in the world, requiring heroic feats of engineering to keep the lines

Susan Karlin



Neogene sequence stratigraphy, Nam Con Son Basin, offshore Vietnam  

Microsoft Academic Search

An integrated well log, biostratigraphic, and seismic stratigraphic study of Miocene to Recent deltaic sediments deposited in the Nam Con Son Basin offshore from southern Vietnam shows the influence of eustacy and tectonics on sequence development. Sediments consist of Oligocene non-marine rift-basin fill (Cau Formation), early to middle Miocene tide-dominated delta plain to delta front sediments (TB 1.5 to TB

K. J. McMillen; E. K. Lee; S. S. Hong



A new compound, Ca3CoN3, with a trigonal planar [CoN3]6- anion  

NASA Astrophysics Data System (ADS)

A new compound, Ca3CoN3, was prepared in a reaction of Ca3N2 and cobalt fine powder under a nitrogen stream at 1000°C. It has a monoclinic unit cell with a = 6.308 Å, b = 5.137 Å, c = 5.933 Å, and ? = 75.1°. It is not isostructural with other A3MN3 but has a closely related structure with a trigonal planar [MN3]6- structural unit where A is an alkaline-earth metal and M = V, Cr, Fe. The Co3+ is assumed to be in a low spin d6 state and to be coordinated by three nitrogen atoms accepting nitrogen's 2p electrons to their d2s hybridized orbitals. Ca3CoN3 is nonmagnetic and semiconducting with a room temperature resistivity of 2.6 x 102 ? cm and with an activation energy of 0.02 eV.

Yamamoto, T.; Kikkawa, S.; Kanamaru, F.



Reputation Social Identity and Social Con‡ict  

Microsoft Academic Search

Abstract We interpret the psychology,literature on social identity and examine,its implications in a population,partially composed,of such agents. We model,a population,of agents from two,exogenous,and,well de…ned social groups. Agents are randomly,matched,to play a reduced,form bargaining,game.,We show,that this struggle for resources drives a con‡ict through,the rational destruction,of surplus. We assume,that the population contains both,rational players and behavioral,players. Behavioral players aggressively discriminate,against members,of the

John Smith


RoboCon: Operator interface for robotic applications  

SciTech Connect

Carnegie Mellon U. and ORNL`s Robotics and Process Systems Division are developing a state-of-the-art robot operator control station (RoboCon) with standardized hardware and software control interfaces to be adaptable to a variety of remote and robotic equipment currently funded by DOE`s Office of Science & Technology Robotics Technology Development Program. The human operation and telerobotic and supervisory control of sophisticated and remote and robotic systems is a complex, tiring, and non-intuitive activity. Since decontamination & decommissioning, selective equipment removal, mixed waste operations, and in-tank cleanup are going to be a major future activity in DOE environmental restoration and waste management cleanup agenda, it seems necessary to utilize an operator control station and interface which maximizes operator comfort and productivity.

Schempf, H.; Warwick, J.; Fung, M.; Chemel, B.; Blackwell, M.



Neogene sequence stratigraphy, Nam Con Son Basin, offshore Vietnam  

SciTech Connect

An integrated well log, biostratigraphic, and seismic stratigraphic study of Miocene to Recent deltaic sediments deposited in the Nam Con Son Basin offshore from southern Vietnam shows the influence of eustacy and tectonics on sequence development. Sediments consist of Oligocene non-marine rift-basin fill (Cau Formation), early to middle Miocene tide-dominated delta plain to delta front sediments (TB 1.5 to TB 2.5, Due and Thong Formations), and late Miocene to Recent marine shelf sediments (TB. 2.6 to TB 3.1 0, Mang Cau, Nam Con Son, and Bien Dong Formations). Eustacy controlled the timing of key surfaces and sand distribution in the tectonically-quiet early Miocene. Tectonic effects on middle to late Miocene sequence development consist of thick transgressive systems tracts due to basin-wide subsidence and transgression, sand distribution in the basin center, and carbonate sedimentation on isolated fault blocks within the basin. Third-order sequence boundaries (SB) are identified by spore peaks, sand stacking patterns, and channel incision. In the basin center, widespread shale beds with coal occur above sequence boundaries followed by transgressive sandstone units. These TST sandstones merge toward the basin margin where they lie on older HST sandstones. Maximum flooding surfaces (MFS) have abundant marine microfossils and mangrove pollen, a change in sand stacking pattern, and often a strong seismic reflection with downlap. Fourth-order genetic-type sequences are also interpreted. The MFS is the easiest marker to identify and correlate on well logs. Fourth-order SB occur within these genetic units but are harder to identify and correlate.

McMillen, K.J. (Beaver Creek Tech. Co., Mason, TX (United States)); Do Van Luu; Lee, E.K.; Hong, S.S. (PEDCO, Ho Chi Minh City (Viet Nam))



Gleevec disminuye la recidiva del cáncer en pacientes con tumor estromal gastrointestinal primario

Los resultados preliminares de un estudio clínico grande aleatorio y controlado con placebo, en pacientes con tumor estromal gastrointestinal (GIST) primario, un tipo de tumor que por lo general se encuentra en el estómago o en el intestino delgado, demostraron que los pacientes a los que se administró mesilato de imatinib (Gleevec®) luego de la extirpación total de su tumor tuvieron una probabilidad significativamente menor de padecer una recidiva del cáncer en comparación con aquellos a los que no se administró imatinib.


Niveles Plasmáticos de Insulina y Glucosa en Diabéticos Tratados con Glibenclamida y Clorpropamida  

Microsoft Academic Search

Riassunto  Sono stati studiati due gruppi di pazienti con diabete stabile dell’età matura, ciascuno costituito da 4 soggetti: il primo\\u000a (gruppo « A ») era stato trattato con glibenclamide durante 20,0 ± 1,1 mesi, il secondo (gruppo « B »), con clorpropamide\\u000a durante 44,2 ± 15,4 mesi. Dopo 3 determinazioni preliminari della glicemia (metodo di Somogyi-Nelson) e dell’insulinemia (metodo\\u000a di Meade

Carlos Aiello; Diego Turner; Néstor J. I. Aparicio; Elda A. de Turner; Alberto Vazquez



Light and Developmental Regulation of the Gene con-10 of Neurospora crassa  

Microsoft Academic Search

The gene con-10 of Neurospora crassa is expressed preferentially during conidiation and following illumination of vegetative mycelia with blue light. In this study we have examined the segmental locations of the genetic elements associated with con-10 that are responsible for light and developmental expression. A translational fusion was prepared between the initial segment of con-10 and Escherichia coli lacZ. Deletions

Luis M. Corrochano; Frank-Roman Lauter; Daniel J. Ebbole; Charles Yanofsky



Performance of the RespiCon personal aerosol sampler in forest products industry workplaces.  


The RespiCon is a multistage virtual impactor that can be used as either a personal or an area sampler. Particles collected on the first stage of the RespiCon represent the respirable fraction of airborne particulate matter. Particles collected on the first and second stages represent the thoracic fraction, and particles collected on the first, second, and third stages represent the inhalable fraction. The RespiCon is available in two versions, one with photometric aerosol detection and a gravimetric version. In this study, the performance of the gravimetric version was examined in various forest products industry facilities. The precision of the RespiCon was assessed and its performance was compared with that of both a respirable cyclone and an inhalable dust sampler. In addition, some RespiCon samples were examined using scanning electron microscopy to determine physical particle size distribution. Under the conditions of this testing, the RespiCon appeared to be reasonably precise. For most sampling locations there was a close correspondence between measurements made with the RespiCon and the CIS personal inhalable sampler or the BGI-4 respirable cyclone. The results of microscopic examination of filters from the RespiCon were consistent with expected performance characteristics. The RespiCon is a useful sampling device for those situations in which it is important to simultaneously collect either personal or area samples of the respirable, thoracic, and inhalable fractions of airborne particulate matter. PMID:12173181

Tatum, Vickie; Ray, Alison E; Rovell-Rixx, David


Pros and Cons of Medical Management of Ulcerative Colitis  

PubMed Central

Ulcerative colitis (UC) is a chronic inflammatory disease characterized by diffuse mucosal inflammation limited to the colon and rectum. Although a complete medical cure may not be possible, UC can be treated with medications that induce and maintain remission. The medical management of this disease continues to evolve with a goal to avoid colectomy and ultimately alter the natural history of UC. Emergence of antitumor necrosis factor-? (TNF-?) agents has expanded the medical armamentarium. 5-Aminosalicylates continue to be used in mild to moderate UC and corticosteroids are mainly used for induction of remission with immunomodulators (6-mercaptopurine/azathiopurine/methotrexate) being applied as steroid-sparing agents for maintenance therapy. Infliximab has been approved by the U.S. Food and Drug Administration and used in the treatment of moderate to severe UC; nevertheless, its use may be associated with significant adverse effects and have a negative impact on the postoperative course should the patients undergo restorative proctocolectomy. In addition, there is always a concern about patients' compliance to medical therapy, cost of medications, and risk for UC-associated dysplasia. The authors discuss the pros and cons of medications used in the treatment of UC.

Navaneethan, Udayakumar; Shen, Bo



Immune cascades in human intervertebral disc: the pros and cons  

PubMed Central

The unique structural hallmark of the intervertebral disc has made its central composition, the nucleus pulposus (NP), excluded from the immunologic tolerance. Consequently, the intervertebral disc is identified as an immune-privileged organ. Traditionally, local detrimental immune activities caused by NP at the lesion sites of the disc are noted as a significant factor contributing to disc degeneration. However, given the beneficial activities of immune cells in other immune-privileged sites on basis of current evidence, the degenerate disc might need the assistance of a subpopulation of immune cells to restore its structure and lessen inflammation. In addition, the beneficial impact of immune cells can be seen in the absorption of the herniated NP, which is an important factor causes the mechanical compression of nerve roots. Consequently, a modulated immune network in degenerate disc is essential for the restoration of this immune-privileged organ. Until now, the understandings of immune response in disc degeneration still rest on the harmful aspect. Further studies are needed to explore its beneficial influence. Accordingly, there are no absolutely the pros and cons in terms of immune reactions caused by NP.

Sun, Zhen; Zhang, Ming; Zhao, Xu-Hong; Liu, Zhi-Heng; Gao, Yang; Samartzis, Dino; Wang, Hai-Qiang; Luo, Zhuo-Jing



Soltando las Amarras - Algunas consideraciones sobre la cancelación de la deuda con el FMI  

Microsoft Academic Search

Este trabajo tiene por objeto analizar dentro de los resultados y proyecciones de la deuda pública, el sentido, impacto y efectos de la decisión gubernamental de cancelar la deuda pública nacional contraída con el FMI. En tal propósito se analizan los motivos que condujeron a la decisión de desendeudarse con el FMI, examinándo las propuestas alternativas a aquella solución, barajadas

Agustin Torres


Detección de anticuerpos antineuronas en pacientes con enfermedades del sistema nervioso: estudio preliminar  

Microsoft Academic Search

RESUMEN Con el objetivo de profundizar en la patogenia de enfermedades que involucren al sistema nervioso central, un colectivo de los laboratorios se dio a la tarea de detectar autoanticuerpos antineuronas en pacientes con estas enfermedades mediante la técnica de inmunofluorescencia indirecta. Se analizaron 31 sueros de pacientes y 72 controles, se obtuvo como resultado una sensibilida d de 77

Raisa Jofra Hernández; Arturo Muster; Roberto Alegre Mendez


ConSearch: An Electronic Document Research and Retrieval Utility for Windows from Management Information Technologies.  

ERIC Educational Resources Information Center

Reviews ConSearch 3.0, a product that provides flexible searching of electronic files, allowing the location of related meanings as well as exact matches. ConSearch 3.0 differs from other file retrieval approaches by relating words in search phrases of questions to the "meaning" of the words, which are stored in a "conceptual database," or lexicon…

Combs, Joseph, Jr.



Alternative Cultural Heterotopia and the Liminoid Body: Beyond Turner at ConFest  

Microsoft Academic Search

This article takes issue with Victor Turner's influential, yet essentialist, category of the limen. While acknowledging Turner's continuing significance in the analysis of public events, I draw upon detailed ethnography of one of Australia's contemporary pilgrimage centres, the alternative lifestyle event ConFest, to reconfigure his project. Although ConFest may prove to be an exemplary field of liminality, as a decidedly

Graham St John



Gestational surrogacy: could be a way to be a way to reproduction? Pros and cons.  


The aim of this article was to address pros and cons of gestational surrogacy, the social and psychological issues involved in surrogate motherhood triads. Pros and cons of surrogacy, the possible insurgence of a hematologic disease in the fetus, hemolytic disease of the newborn, naturally acquired microchimerism in surrogacy cases, ethical, medical, psychologic, legal and religious issues of a problem are discussed. PMID:21778533

Clementina, Peris



Effect of Sup 60 Co gamma Rays on Con A and LPS Induced Lymphocytes.  

National Technical Information Service (NTIS)

The effect of /sup 60/Co gamma -rays on lymphocytes induced by Con A and LPS and the relationship between these two groups of cells were investigated by means of /sup 3/H-TdR incorporation. The study showed that in vitro, Con A cells were able to promote ...

Su L. Liu K. Ma X



CON1D: a computer program for calculating spherically symmetric droplet combustion  

Microsoft Academic Search

This report documents CON1D, a computer program which solves the balance equations describing the spherically symmetric vaporization or combustion of a liquid fuel droplet. CON1D is intended to complement the existing theory of droplet combustion by obtaining solutions in cases which are analytically intractable. For example, calculations are described which clearly demonstrate the effects of gas phase unsteadiness on droplet

R. D. Janssen; P. J. ORourke



A National Look at Postmodernism's Pros and Cons in Educational Leadership  

ERIC Educational Resources Information Center

The purpose of this article is to take a look at the pros and cons of postmodernism. It is imperative for administrators to closely examine educational theories and practices prior to instituting changes. The ability to read and digest challenging material keeps one informed and prepared to lead effectively. This paper will list the pros and cons

Townsell, Rhodena



La gestión de las relaciones con clientes y la empresa de alta rentabilidad de Galicia  

Microsoft Academic Search

RESUMEN La gestión de las relaciones con los clientes es un factor diferencial de las empresas de alta rentabilidad (AR), organizaciones que poseen un elevado rendimiento económico. El presente trabajo propone profundizar en la gestión de clientes como fuente de ventaja competitiva, aplicando la perspectiva de los recursos y capacidades. Con esta finalidad, ofrecemos los resultados obtenidos tras la realización

Pablo Cabanelas Lorenzo; Anxo Moreira



Day\\/Night and Circadian Rhythm Control of Con Gene Expression in Neurospora  

Microsoft Academic Search

In the filamentous fungus Neurospora crassa, several events in the process of conidiation are influenced by light. Two genes, con-6 and con-10, which were previously shown to be transcriptionally activated during conidiation and by exposure to light, were found to be unexpressed in mycelium maintained in constant darkness or in constant light. However, when mycelium was shifted from darkness to

Frank-Roman Lauter; Charles Yanofsky



Well-differentiated thymic carcinoma: a clinico-pathological study.  


Well-differentiated thymic carcinoma (WDTC) is a recently described epithelial tumour of the thymus previously classified as cortical or predominantly epithelial thymoma. The authors have reviewed a series of 15 cases of WDTC with the aim of further defining the clinicopathological features of this neoplasm. Histologically, the number of lymphocytes was always low; perivascular spaces and epithelial palisading around blood vessels and/or along fibrous septa were prominent features; 6 cases (40%) were associated with areas of typical cortical thymoma. All cases showed slight to moderate cytological atypia and nuclear grooving was frequently detected. Mitotic activity was variable but usually low. Clinically, all but 3 cases (80%) were invasive at surgery; myasthenia gravis was present in 9 cases (60%); 5 patients (33.3%) died due to disease and 2 additional patients (13.3%) had tumor recurrence. Our study indicates that WDTC has fairly distinctive clinicopathological features and that it is histologically and histogenetically related to cortical thymoma. The definition "well-differentiated carcinoma" is justified because of low-grade cytological atypia and retention of some organotypical histological features, in a tumour otherwise often displaying aggressive and sometimes clear-cut malignant clinical behaviour. PMID:1549907

Pescarmona, E; Rosati, S; Rendina, E A; Venuta, F; Baroni, C D



Well-differentiated thymic carcinoma: a clinico-pathological study  

Microsoft Academic Search

Summary  Well-differentiated thymic carcinoma (WDTC) is a recently described epithelial tumour of the thymus previously classified\\u000a as cortical or predominantly epithelial thymoma. The authors have reviewed a series of 15 cases of WDTC with the aim of further\\u000a defining the clinicopathological features of this neoplasm. Histologically, the number of lymphocytes was always low; perivascular\\u000a spaces and epithelial palisading around blood vessels

Edoardo Pescarmona; Stefano Rosati; Erino A. Rendina; Federico Venuta; Carlo D. Baroni



Estrogen Receptors in Prolactinomas: A Clinico-Pathological study  

Microsoft Academic Search

Background: Antiestrogens are effective in the treatment of estrogen receptor (ER) positive breast carcinoma. The use of antiestrogen therapy in pituitary adenomas, however, has not been explored. This study attempted to identify a population who may benefit from antiestrogen therapy.

G. J. Kaptain; N. E. Simmons; T. D. Alden; M. B. Lopes; M. L. Vance; E. R. Laws



A clinico-pathological study of vulval dermatoses.  

PubMed Central

A long-term review of 108 women suffering from various forms of vulval dermatosis is described and a detailed analysis of those with chronic hypertrophic vulvitis, lichen sclerosus et atrophicus, and neurodermatitis is made. One case of neurodermatitis and two cases of lichen sclerosus progressed to carcinoma but no case of chronic hypertrophic vulvitis became malignant. It is possible that vulval dermatoses occur more commonly in the nulliparous than in the parous women and there is a slight preponderance of women who are blood group A. It is suggested that the term "leukoplakia" should be abandoned and that vulval lesions should be described in precise and meaningful histological terms. Images

Leighton, P C; Langley, F A



[Human monkey pox: its clinico-epidemiological characteristics].  


During the course of the smallpox eradication programme, a new eruptive disease clinically resembling smallpox was discovered in Zaire. The disease, which was named monkeypox after the virus, is a zoonosis occurring sporadically in countries of western and central Africa with tropical rain forest. The studies carried out in Zaire from 1980 through 1985 showed that monkeypox affects mainly children in relatively small remote villages whose population has traditionally frequent contacts with wild animals. Apart from the wildlife, the virus can be transmitted from man to man, but among other sources of infection sick persons did not exceed 20%. Presumed human transmission has occurred in 38 out of 61 outbreaks of human monkeypox and only once reached the third and once the fourth generation; the transmission in all affected villages under observation has extinguished itself. Considering the sporadic and relatively rare occurrence of the disease and expected complications following the immunization with vaccinia which protects from monkeypox, introduction of mass vaccination in the areas at risk is hardly justified at present. PMID:2845688

Jezek, Z; Khodakevich, L N; Szczeniowski, M V



[Epileptic activity of the occipital lobe. Clinico-electroencephalographic contribution].  


Our analysis of the course of illness in 14 patients, whose common electroencephalographic characteristic was epileptogenic activity in the occipital area, showed very different clinical symptoms. The first group comprised patients who presented bilateral amaurosis. In four of these cases, the occipital hypersynchronous EEG activity was merely a secondary symptom of either ischaemic hypoxia or of a degenerative process in the occipital visual cortex and was not responsible for the genesis of the actual blindness. In two further cases of monosymptomatic temporary loss of vision, it was difficult to make a differential diagnosis between ictal blindness, respectively status epilepticus amauroticus occurring in a occipital lobe epilepsy and a migraine attack involving the basilar territory. The second group comprised five patients with paroxysmal visual hallucinations respectively illusions. Three of them suffered from hallucinations of the elementary type, respectively flickering fits in the hemianopic field, symptoms which are based on discharges in the visual cortex of the occipital lobe. In a case of one patient with complex visual hallucinations as well as in a further case with visual illusions, it was not possible to find out with certainty their place of origin. A study of these cases shows that the cortical or sub-cortical functional disturbance within the visual system causing the various optical deformations and visual hallucinations, form an inhomogeneous group with different etiology. In the only patient belonging to the third group, whose seizures were i.a. characterized through motor phenomena in the field of the ocular organs and the tonic lateral turning movement of the bulbi of the eyes and of the head, an occipital epileptic crisis with spread of discharges from the occipital pole to the frontomesial surface should be assumed. The occurrence of complex partial seizures, respectively generalized tonic-clonic attacks in two patients of the fourth group who have definite epileptogenic EEG-activity in the occipital area, can be explained by a propagation of paroxysmal activity to the temporal lobe or to the motor cortex. Because of the marked tendency to propagation of the hypersynchronous activity originating in the occipital lobe, many combinations of sensory and/or motor symptoms can occur within the frame-work of occipital epileptic seizures. On the basis of one scalp EEG finding, no final localizing conclusions may be drawn here. PMID:3220420

Schäffler, L; Karbowski, K



“Top of the basilar” syndrome: Clinico-radiological evaluation  

Microsoft Academic Search

Sixteen patients having infarction caused by circulatory disturbance at the top of the basilar artery, that is to say, the “top of the basilar” syndrome, were studied, the diagnosis having been made by computerized tomography. Infarcts were widely distributed in each patient between the thalamus, midbrain, pons, cerebellum, and occipital lobe. Both thalami were involved in 7 cases. When the

M. Sato; S. Tanaka; A. Kohama




Microsoft Academic Search

The aim of this study was to know the clinical and haematological changes in female rabbits following the treatment with cypermethrin (CY). In this study, 24 female rabbits were divided randomly into four equal groups A, B, C and D. Groups A, B and C were injected intraperitoneally CY @ 25, 50 and 75 mg\\/Kg b. wt., respectively, while the



Clinico- pathological profile of patients with breast diseases  

PubMed Central

Background To evaluate the spectrum of breast diseases and their association with presenting complains of patients. Methodology It was a cross sectional study conducted from 1st January 2010 – 30th December 2012. A total of 254 breast specimens of patients, who were admitted in Civil Hospital Karachi with breast complaints, were included. Specimens were collected either from mastectomy, lumpectomy or needle biopsy from the admitted patients. Informed written consent was taken from all the patients. All patients with primary breast diseases were included. Patients undergoing chemotherapy or with secondary breast disease and slides with insufficient specimen were excluded. All data was entered and analyzed through SPSS 19. Result There were 254 breast lesions, histologically diagnosed in 3 year review period. The overall mean age of patients with breast lesion was 25.18, SD?±?11.73 with a wide age range of 12–74 years. Most common cases identified are benign 191(75.3%), followed by inflammatory 30(11.8%) and malignant lesions 30(11.8%). Most patients presenting with the complain of pain have diagnosis of fibroadenoma 24 (63.2%) while patient with complain of lump also have the most common diagnosis of fibroadenoma 147 (72.8%). Conclusions Study shows that in Pakistani females, mostly encountered breast lesion was fibroadenoma. Due to lack of awareness breast diseases present lately. Awareness must be created among women to reduce the mortality and morbidity with breast lesions. Virtual slides The virtual slide(s) for this article can be found here:



Metastatic sweat gland adenocarcinoma: A clinico-pathological dilemma  

PubMed Central

Background Sweat gland adenocarcinoma is a rare malignancy with high metastatic potential seen more commonly in later years of life. Scalp is the most common site of occurrence and it usually spreads to lymph nodes. Liver, lung and bones are the distant sites of metastasis with fatal results. The differentiation between apocrine and eccrine metastatic sweat gland carcinoma is often difficult. The criteria's are inadequate to be of any practical utility. Case Report Two cases of metastatic sweat gland adenocarcinoma (one of eccrine and the other one of apocrine origin) are being reported on account of the rarity and different outcome. Conclusion Sweat gland carcinomas are rare cancers with a poor prognosis often presenting as histological surprises. Surgery in the form of wide local excision and lymph node dissection is the mainstay of treatment. Chemotherapy and/or radiotherapy has limited role.

Chintamani; Sharma, RD; Badran, Rohini; Singhal, Vinay; Saxena, Sunita; Bansal, Anju



A Clinico-Pathological Study on Benign Breast Diseases  

PubMed Central

Background: To study the patterns of clinically benign breast disease in females and to co-relate them with the pathological findings. Methods: One hundred females who attended the Surgery Outpatients Department in Indira Gandhi Medical College and Research Institute, Pondicherry, with various forms of benign breast diseases during the period from October 2011 to September 2012, were studied. Early diagnoses by doing a triple assessment like a clinical examination, FNAC or a core needle biopsy and imaging methods like ultrasonography or mammography, were made within 72 hrs from the first consultation. The clinical diagnoses were compared with the cytological or histological findings wherever possible and their accuracies were evaluated. Results: Out of the 100 female patients who were studied, 87 patients who presented with breast lumps and fibroadenoma, accounted for 48% of the cases, which was the highest number of patients. Fibrocystic changes and breast abscesses came next with 18% and 12% cases respectively. We detected 3 cases of proliferative disease with atypia and one case with florid hyperplasia, which had high and low risk factors respectively, for developing invasive carcinoma. The oldest lady of the group who was clinically diagnosed to have benign disease, was detected to have invasive ductal carcinoma. They were treated in our hospital and were advised follow up. Conclusion: Benign breast diseases are common in female patients and fibroadenoma is the commonest of them all. Triple assessment provided a quick diagnosis and it alleviated unnecessary anxiety from the patients about breast cancer. The clinical diagnosis of a breast lump, as confirmed by cytology and histology, was accurate in 91.95 % of the cases.

Sangma, Mima B. Maychet; Panda, Kishori; Dasiah, Simon



Clinico-radiologic Findings in Group II Caudal Regression Syndrome  

PubMed Central

Caudal regression syndrome (CRS) is a rare congenital abnormality in which a segment of the lumbo-sacral spine and spinal cord fails to develop. The severity of the morphologic derangement inversely correlates with residual spinal cord function. We present a case report of a 10-year-old girl with Group 2 CRS, to emphasize clinical and radiologic findings in this rare abnormality.

Sharma, Pankaj; Kumar, Sheo; Jaiswal, Awdesh



Clinico-pharmacological aspects of different hormone treatments  

Microsoft Academic Search

During the last decade, several new drugs and classes of drugs have become available for breast cancer treatment. Thus, in addition to tamoxifen we have got several new selective oestrogen receptor modulators (SERMs) with a partially different pharmacological profile. The first generation aromatase inhibitor, aminoglutethimide, has been replaced by more potent and less toxic inhibitors belonging to the triazole class

P. E Lønning



Congenital combined orbito-nasal lipoblastoma: clinico-pathologic study.  


The authors present the clinical picture, histopathologic findings and surgical treatment of an infant born with a lipoblastoma involving an unusual combined orbito-nasal location. To the best of our knowledge, this is the first report of congenital lipoblastoma extension from orbit to the nasal cavity. Transconjunctival orbitotomy with excisional biopsy of tumor was performed. Histology specimen that demonstrates the small embryonal fat cells in different stages of maturation and the characteristic lobulation of the fat tissue are presented. The embryonic origin, timing of development of the tumor during gestation, as well as the route of propagation from orbit to nose are discussed. The authors conclude that complete excision of this tumor, with preservation of normal tissue, may bring cure to the young patient without gross functional deformity. PMID:17613861

Seider, Nir; Gilboa, Michael; Barishak, Yomtov R; Miller, Benjamin



[Clinico-anatomic parallels of cardiac lesion in sporadic influenza].  


Data on 40 patients (21 men, 19 women) who died in hospital of influenza in 1975-1990 are analysed. The age of the patients ranged from 47 to 92 years, 37 patients were over 60. 31 deceased had ischemic heart disease (IHD), of them 13 survived myocardial infarction; 11 patients had essential hypertension, 1--lymphoid leukemia, 1--pollenosis. Influenza caused by virus of A type (H3N2) was diagnosed in 27 patients. Influenza virus type B was detected in 13 patients. The disease ran a hypertoxic, severe and moderate course in 3, 20 and 17 patients, respectively. Influenza complicated with pneumonia in 23 cases, with hemorrhagic edema in 4 patients. The lethal outcome was caused by acute cardiovascular failure (n = 20) including acute myocardial infarction (n = 9), pulmonary edema (n = 9), pulmonary artery thromboembolism (n = 8). Influenza remains a serious disease especially for the elderly with IHD. PMID:11641939

Bogomolov, B P; Mal'kova, T N; Deviatkin, A V



Determination of composition in stoichiometric Co-N ultrathin films by nitrogen plasma sputtering  

SciTech Connect

This work utilizes low-energy sputtering to incorporate the generated nitrogen plasma into an epitaxial 1.4 nm Co film on the surface of a ZnO(002) substrate. In this method, ultrathin Co-N amorphous films were formed. Interestingly, Co is key to the formation of Co-N films. Without the deposition of Co on the ZnO(002), nitride films cannot be formed. Observations of the surface composition of the Co-N films after the firing of a N{sup +} ion beam onto it demonstrated that the surface concentration of Co reduced at the same rate as the reduction in the concentration of N upon successive sputtering. Theoretical calculations based on the Auger peak-to-peak amplitudes established that the composition of the amorphous Co-N thin films may be Co{sub 3}N{sub 2}.

Su, C. W.; Huang, M. S.; Chang, Y. C.; Tsai, T. H. [Department of Applied Physics, National Chiayi University, 300 Syuefu Rd., Chiayi 60004, Taiwan (China); Lee, Y. H.; Lee, J. C. [Department of Physics, National Cheng Kung University, 1 University Rd., Tainan 70101, Taiwan (China)



The Environmental Impact of Supplying Power to the Con Edison Service Territory: 1975-1990.  

National Technical Information Service (NTIS)

This report describes present and anticipated environmental consequences of meeting electricity demand in the Con Edison service territory--New York City and most of Westchester County. Important issues include nuclear power, air pollution, water and aqua...

A. K. Freedman J. C. Cohen



Il trattamento di una grave neuropatia diabetica con insulina somministrata per via endorachidea  

Microsoft Academic Search

Riassunto Viene descritto un caso di grave poliradicoloneurite diabetica che non aveva tratto alcun miglioramento da un lungo trattamento con vitamina B1 e B12 ad alti dosaggi. Esso giunse a guarigione somministrando insulina direttamente nello speco vertebrale.

Sergio Marigo; Enrico Ferrero



All Frames Are Not Equal: Framing and Con?ict Displacement  

Microsoft Academic Search

Abstract Issue framing afiects individual opinions, mass sentiment, and policy. While most frames reinforce the status quo distribution of opinion, occasionally frames redraw the line of debate. These \\\\con?ict- displacing\\

Suzanna De Boef; Frank R. Baumgartner; Amber E. Boydstun; Frank E. Dardis; Fuyuan Sheny


Quimioterapia de alta dosis prolonga en forma significativa la supervivencia en pacientes con leucemia mieloide aguda

Los resultados preliminares de un estudio clínico grande con asignación al azar de pacientes de 16 a 60 años de edad con leucemia mieloide aguda (LMA), un cáncer de la sangre y de la médula ósea, que no había sido tratada anteriormente, muestran que los pacientes que recibieron una alta dosis de daunorrubicina, un fármaco de quimioterapia disponible comercialmente, durante la terapia inicial vivieron más que los pacientes que recibieron una dosis normal del mismo fármaco.


Análisis comparativo de 3 regímenes de tratamiento en niños con linfoma de Burkitt  

Microsoft Academic Search

Resumen  De enero de 1980 a junio de 1996 se trataron en nuestra institución un total de 86 pacientes con linfoma de Burkitt. El presente\\u000a estudio es una revisión retrospectiva en el que se comparan las complicaciones y los resultados de sobrevida utilizando 3\\u000a esquemas de tratamiento distintos.\\u000a \\u000a Se trataron 46 pacientes en el régimen 1, 26 con el régimen 2,

Rocío Cárdenas Cardós; Roberto Rivera Luna; Roxana Martínez Agreda; Carlos Calderón Elvir; Amparo Plata García



Lupus eritematoso sistemico: un caso di difficile diagnosi differenziale con forme infettive  

Microsoft Academic Search

purpurica, diffuse a tutto il corpo, compresi palmo delle mani e pianta dei piedi. È presente linfoadenopa- tia laterocervicale bilaterale, con linfoghiandole non dolenti, mobili, di 1-2 cm di diametro. Alla palpa- zione dell'addome si evidenzia epa- tosplenomegalia marcata con en- trambi gli organi debordanti tre dita dall'arcata costale. Gli esami ematici eseguiti all'in- gresso (Tab. I) mostrano aumento della




FReCon: a fluid remote controller for a FReely connected world in a ubiquitous environment  

Microsoft Academic Search

In this paper, we propose a Fluid Remote Controller, a general-purpose remote controller based on the ubiquitous computing view. FReCon offers remote control features over a wide range of appliances located within a room, with a unique controller implemented on portable devices like PDAs, handheld PCs, mobile phones, etc. More than the controller itself, FReCon means the whole FReely Connected

Alexandre Sanguinetti; Hirohide Haga; Aya Funakoshi; Atsushi Yoshida; Chiho Matsumoto



THE BATTLE OF THE BANDS ConFest Musics and the Politics of Authenticity  

Microsoft Academic Search

he Australian alternative lifestyle event ConFest (Conference\\/Festival) harbours a dynamic 'underground' music culture. This article investigates the role performed by musics in efforts to establish and maintain 'sanctified' space, and a concomitant sense of community, at Australia's principal alternative cultural pilgrimage destination. The performance, aesthetics and sociality of musics are pivotal in struggles over the definition and purpose of ConFest.




Microsoft Academic Search

La partecipazione di ARPA-SIM al progetto Interreg SEDEMED ha riguardato, per la parte meteorologica, lo studio dei fenomeni siccitosi in Emilia-Romagna attraverso l'indice SPI (Standardized Precipitation Index) e la sua correlazione con la circolazione atmosferica a larga scala e con pattern di variabilità atmosferica, quali la NAO (North Atlantic Oscillation). In ambito agrometeorologico è stata invece studiata la siccità agricola,



SciTech Connect

The purpose of this document is to release, into the Hanford Document Control System, FA1/0991, Sludge Particle Separation Efficiencies for the Rectangular SCS-CON-230 Container, by M. Epstein and M. G. Plys, Fauske & Associates, LLC, June 2009. The Sludge Treatment Project (STP) will retrieve sludge from the 105-K West Integrated Water Treatment System (IWTS) Settler Tanks and transfer it to container SCS-CON-230 using the Settler Tank Retrieval System (STRS). The sludge will enter the container through two distributors. The container will have a filtration system that is designed to minimize the overflow of sludge fines from the container to the basin. FAI/09-91 was performed to quantify the effect of the STRS on sludge distribution inside of and overflow out of SCS-CON-230. Selected results of the analysis and a system description are discussed. The principal result of the analysis is that the STRS filtration system reduces the overflow of sludge from SCS-CON-230 to the basin by roughly a factor of 10. Some turbidity can be expected in the center bay where the container is located. The exact amount of overflow and subsequent turbidity is dependent on the density of the sludge (which will vary with location in the Settler Tanks) and the thermal gradient between the SCS-CON-230 and the basin. Attachment A presents the full analytical results. These results are applicable specifically to SCS-CON-230 and the STRS filtration system's expected operating duty cycles.




Evaluation of the ACT*DE*CON{sup SM} process for treating gunite tank sludge  

SciTech Connect

A test was conducted to evaluate this process for selectively removing actinides from Gunite tank sludge. Mixed waste sludge from Gunite tank W-6 was subjected to the ACT*DE*CON selective leaching process. (Nearly all the TRU content was attributed to Pu.) The sludge sample was first washed with 0.01M NaOH to remove excess sodium and nitrate in the interstitial liquid supernatant. The washed wet solids were treated with the ACT*DE*CON solvent (aqueous carbonate solution containing a chelating agent and an oxidant), using a ratio of 20 ml solvent per gram wet solids. Sludge and solvent were separated by centrifugation, and the ACT*DE*CON treatment was repeated twice. Analyses showed that 71% of the solids in the sludge were dissolved while 80% of the TRU-waste components dissolved. Low separation of the TRU-waste components from other components of the sludge mixture is indicated. Almost all the U and Ca were removed from the sludge. For sludges where most of the TRU content is Pu, the ACT*DE*CON process as tested is not effective in rendering the sludge a non-TRU waste. It is recommended that ACT*DE*CON be optimized for this specific application and that other processes using different chelating and oxidizing agents be tested. Also, the ACT*DE*CON process should be tested on TRU mixed waste in which most of the TRU elements are not Pu.

Spencer, B.B.; Chase, C.W.; Egan, B.Z.



Pros and cons: prospective predictors of marijuana use on a college campus.  


Marijuana use on college campuses is prevalent and associated with high rates of abuse and dependence. The Marijuana Decisional Balance (MDB) scales measure perceived pros and cons toward marijuana use. Evidence supports reliability and concurrent validity of these scales, but the predictive validity has not yet been assessed. The current study evaluated the prospective predictive validity of pros and cons scales for marijuana use, as well as explored predictive validity for marijuana problem indicators. Secondary analyses included test-retest reliability and internal consistency, to provide additional evidence of psychometric properties. A total of 149 college students (57% recent marijuana users, 77% lifetime users) participated in a baseline survey, then completed a second survey one month later. All provided data on marijuana pros and cons, as well as use status in the past month. Users at each time point reported on use frequency, problems, and disorder symptoms. In the month between assessments, 55% of the students used marijuana. Both pros and cons subscales prospectively predicted use status in the subsequent month, but not use frequency. Pros prospectively predicted marijuana problems and dependence symptoms at follow-up, and remained a significant predictor of later dependence symptoms even after controlling for baseline dependence symptoms. In contrast, pros only marginally predicted abuse. Cons did not predict problems, abuse, or dependence symptoms. Pros and cons showed strong test-retest reliability (rs = 0.80-0.85) and internal consistency (alphas = 0.92-0.95). In a college sample, pros and cons of marijuana use demonstrated stability over one month, and prospectively predicted use. Pros may also have utility in predicting problems and dependence potential on college campuses. PMID:22985053

Elliott, Jennifer C; Carey, Kate B



Influence of in vitro irradiation upon LIF production by ConA stimulated mononuclear cells  

SciTech Connect

Leukocyte migration inhibitory factor (LIF) activity of culture supernatants of in vitro irradiated Concanavalin A (ConA) stimulated lymphocytes was tested by measuring granulocyte migration from clotted plasma droplets placed in flat bottom microplates. The specificity of inhibition was assured by pretreating the assay supernatants with anti-LIF antibodies which abrogated granulocyte migration inhibition but did not impair guinea pig Peritoneal Exudate Cells (PEC) migration inhibition. In vitro irradiation (150-1200 rad) of MNC cultures either before or after ConA stimulation did not impair lymphokine production and sometimes significantly improved the supernatants' LIF activity as compared with that of unirradiated cultures. The existence of radiosensitive suppressor cells regulating LIF production by ConA stimulated mononuclear cells is suggested.

Sandru, G.; Veraguth, P.



Influence of in vitro irradiation upon LIF production by ConA stimulated mononuclear cells  

SciTech Connect

Leukocyte migration inhibitory factor (LIF) activity of culture supernatants of in vitro irradiated Concanavalin A (ConA) stimulated lymphocytes was tested by measuring granulocyte migration from clotted plasma droplets placed in flat bottom microplates. The specificity of inhibition was assured by pretreating the assay supernatants with anti-LIF antibodies which abrogated granulocyte migration inhibition but did not impair guinea pig Peritoneal Exudate Cells (PEC) migration inhibition. In vitro irradiation (150-1200 rads) of MNC cultures either before or after ConA stimulation did not impair lymphokine production and sometimes significantly improved the supernatants' LIF activity as compared with that of unirradiated cultures. The existence of radiosensitive suppressor cells regulating LIF production by ConA stimulated mononuclear cells is suggested.

Sandru, G.; Veraguth, P.



Distribución espacial de cúmulos y asociaciones estelares con diferentes edades en la Nube Mayor de Magallanes  

NASA Astrophysics Data System (ADS)

Sobre la base de observaciones realizadas en Cerro Tololo y el Casleo, se presenta un catálogo con fotometría UBV integrada de 504 cúmulos y 120 asociaciones estelares en la Nube Mayor de Magallanes. Se determinan edades en términos de los tipos SWB y se identifican 38 cúmulos tipo VII, muchos de los cuales pueden ser cúmulos globulares clásicos. El tamaño de las distribuciones espaciales crece uniformemente con la edad (tipo SWB), en tanto que existe una diferencia en el cociente axial entre los grupos más jóvenes y más viejos que 30 millones de años, lo que implica una orientación aproximadamente de frente para los primeros y una posición inclinada ~ 45o para el segundo grupo. Las asimetrías en las distribuciones espaciales, juntamente con la falta de coincidencia de los centroides de los diferentes grupos de edad, sugiere que el disco de la Nube Mayor de Magallanes fue severamente perturbado en el pasado.

Bica, E.; Clariá, J. J.; Dottori, H.; Santos, J. F. C.; Piatti, A. E.


Null alleles for salivary Concanavalin A-binding (Con A) and Po proteins at PRB2 and PRB4 loci  

SciTech Connect

Six closely linked PRP (proline-rich protein) genes code for many salivary PRPs which show frequent null variants especially. The Con polymorphism includes the different sized Con 1 and Con 2 proteins and the null Con 0 form. N-terminal amino acid sequences (60 aa) were determined on Con 1 and Con 2 proteins. From comparison of the protein sequences with those deduced from published PRP DNA sequences, Con proteins are probably encoded within exon 3 of the PRB2 gene. Both PRB2 alleles were then cloned from an individual with the Con1/Con 2 phenotype and one PRB2 allele from the individual with the Con 0 phenotype. From DNA sequence analysis, Con 1 is probably a 124 aa protein that is derived by proteolytic processing from a larger precursor, and there are two signals (NKS) for asparagine-linked carbohydrate attachment. However, from the n-terminal protein sequence, the first site is not used. A single nucleotide substitution in the Con 0 allele causes a coding change mutation [TCT (Ser){yields}CCT(Pro)] that abolishes the postulated single functional carbohydrate attachment site (NKS{yields}NKP) and explains the absence of Con 1 protein staining on the Western blot in Con 0 homozygotes. The n-terminal sequence of the Con 2 protein was not encoded in either PRB2 allele from the individual with the Con 1/Con 2 phenotype and must be encoded by another PRB locus. The non-glycosylated 70 aa Po protein which shows Po+ and Po- phenotypes was known to be encoded by exon 3 of the PRB4 gene. The DNA sequence from exon 3 of PRB4 from an individual with the Po- phenotype was compared to that previously published from a Po+ individual. A nucleotide substitution was found at the {open_quotes}invariant{close_quotes} +1 position [GT{yields}CT] of the exon 3 5{prime}-splice site. This mutation adequately accounts for the Po- phenotype.

Azen, E.A.; Amberger, E. [Univ. of Wisconsin, Madison, WI (United States)



Soluciones analiticas AL problema de jets con velocidad de eyeccion variable EN EL tiempo.  

NASA Astrophysics Data System (ADS)

Se presenta un nuevo metodo que permite resolver de manera exacta y analitica las ecuaciones que describen un jet hipersonico con velocidad de eyeccion variable en el tiempo. El metodo se basa en consideraciones sencillas de conservacion de momento para las superficies de trabajo que se forman en el interior del jet. Como ejemplo, se presentan soluciones para jets con variacion sinusoidal en la velocidad de eyeccion, y tambien para el caso de un incremento lineal en el tiempo. Estas soluciones analiticas tienen una clara aplicacion en la interpretacion de las observaciones de jets asociados a objetos Herbig-Haro.

Canto, J.; Raga, A. C.; D'Alessio, P.



Clinico-biologic features and treatment outcome of adult pro-B-ALL patients enrolled in the GIMEMA 0496 study: absence of the ALL1\\/AF4and of the BCR\\/ABLfusion genes correlates with a significantly better clinical outcome  

Microsoft Academic Search

24, 2o f 6, and 6o f 36 of theALL1\\/AF4- positive, BCR\\/ABL-positive, and ALL1\\/ AF4-BCR\\/AB-negative patients, respec- tively (P.007). None of the 24 ALL1\\/AF4- positive patients coexpressed the CD13 and\\/or CD33 myeloid antigens. By con- trast, CD13 and CD33 molecules were detected, respectively, in 3 of 6 and in 14 of 33 cases of the BCR\\/ABL-positive pa- tient group, and

Giuseppe Cimino; Loredana Elia; Marco Mancini; Luciana Annino; Barbara Anaclerico; Paola Fazi; Antonella Vitale; Giorgina Specchia



Salud con Sabor Latino: a culturally sensitive obesity prevention curriculum in an underserved Latino community  

Microsoft Academic Search

Salud con Sabor Latino is a culturally sensitive obesity prevention curriculum that incorporates the traditions and values of the Latino community and family. The 4-week curriculum meets twice a week and includes an education and cooking component. Key components of the curriculum are portion size, reading food labels, taking small steps, eating a variety of foods, and the importance of

Christina Araiza; Maria Valenzuela; Bonnie Gance-Cleveland



The Con Edison Emergency Child Care Plan for Management Employees: Summary Plan Description.  

ERIC Educational Resources Information Center

This summary plan description offers guidelines for participation in a pilot program that provides short-term emergency care for children of Con Edison managers who are under 13 years old. The plan offers professional, in-home child care that can be used when usual arrangements have collapsed. The summary plan description addresses the following…

Consolidated Edison Co., Brooklyn, NY.


ConText: An algorithm for determining negation, experiencer, and temporal status from clinical reports  

Microsoft Academic Search

In this paper we describe an algorithm called ConText for determining whether clinical conditions mentioned in clinical reports are negated, hypothetical, historical, or experienced by someone other than the patient. The algorithm infers the status of a condition with regard to these properties from simple lexical clues occurring in the context of the condition. The discussion and evaluation of the

Henk Harkema; John N. Dowling; Tyler Thornblade; Wendy Webber Chapman



The pros and cons of computing the h-index using Google Scholar  

Microsoft Academic Search

Purpose – A previous paper by the present author described the pros and cons of using the three largest cited reference enhanced multidisciplinary databases and discussed and illustrated in general how the theoretically sound idea of the h-index may become distorted depending on the software and the content of the database(s) used, and the searchers' skill and knowledge of the

Pe´ter Jacso´



Sludge Particle Separation Efficiencies During Settler Tank Retrieval Into SCS-CON-230.  

National Technical Information Service (NTIS)

The purpose of this document is to release, into the Hanford Document Control System, FA1/0991, Sludge Particle Separation Efficiencies for the Rectangular SCS-CON-230 Container, by M. Epstein and M. G. Plys, Fauske & Associates, LLC, June 2009. The Sludg...

J. I. Dearing M. Epstein M. G. Plys




Microsoft Academic Search

El chile jalapeño provoca un alto nivel de irritación a diferentes niveles del tracto estomacal en comparación con el chile habanero. A pesar de que el chile habanero presenta una mayor capacidad pungente, no es irritante. A la fecha se desconoce la naturaleza de los compuestos responsables de este efecto. En el presente trabajo se reporta el análisis preliminar de

Salvador Horacio; Guzmán Maldonado; Irineo Torres Pacheco; Mario González Chavira; María Alejandra; Mora Avilés; Guadalupe Herrera Hernández; David Hernández López


Immunostimulatory activity of ConBr: a focus on splenocyte proliferation and proliferative cytokine secretion.  


Lectins constitute a class of glycoproteins, which are capable of selectively and reversibly binding to carbohydrates, distinguishing small structural differences in complex oligosaccharides. Studies have shown that the binding of lectins to cell-surface carbohydrates can lead to various effects such as cellular proliferation, histamine release and cytokine production. Canavalia brasiliensis lectin (ConBr) is a (D-mannose) D-glucose lectin. In this study, murine splenocytes were cultured to determine the effect of ConBr on cell proliferation, nitric oxide (NO) release and cytokine secretion. In addition, cellular viability assays were performed to evaluate any mitogenic activity induced by this lectin. ConBr significantly increased cell proliferation with minimal cell damage. This lectin was able to induce an increased production of cytokines such as IL-2, IL-6 and IFN-? and a decreased production of IL- 10. The release of NO was also observed. The results of this study indicate that ConBr could potentially be used as an immunomodulator. PMID:22009293

de Oliveira Silva, Flávio; das Neves Santos, Priscila; de Melo, Cristiane Moutinho Lagos; Teixeira, Edson Holanda; de Sousa Cavada, Benildo; Arruda, Francisco Vassiliepe Sousa; Cajazeiras, João Batista; Almeida, Alysson Chaves; Pereira, Valéria Alves Rêgo; Porto, Ana Lúcia Figueiredo



Stress state in the Cuu Long and Nam Con Son basins, offshore Vietnam  

Microsoft Academic Search

The results presented in this paper are the first published estimates of the complete stress tensor in the Cuu Long and Nam Con Son basins, offshore Vietnam. We analysed in situ stress and pore pressure fields in the sedimentary formations using data from petroleum exploration and production wells to evaluate the stress state in these basins. The data were obtained

Nguyen Thi Thanh Binh; Tomochika Tokunaga; Neil R. Goulty; Hoang Phuoc Son; Mai Van Binh



Structure, stratigraphy and petroleum geology of the south east Nam Con Son Basin, offshore Vietnam  

Microsoft Academic Search

Recent exploration of the south east Nam Con Son Basin, offshore Vietnam, by BP in alliance with Statoil has involved acquisition of new seismic and well data. These new data have allowed re-evaluation of the tectono-stratigraphic development and petroleum geology, and have provided additional constraints on the regional tectonic evolution. The offshore Vietnamese basins have evolved in response to the

A. J. Fraser; S. J. Matthews; S. Lowe; S. P. Todd; Simon; F. J. P. Peel



The pros and cons of Microsoft Academic Search from a bibliometric perspective  

Microsoft Academic Search

Purpose – This paper aims to look at the pros and cons of Microsoft Academic Search (MAS) from a bibliometric perspective. Design\\/methodology\\/approach – This paper describes the major content and software features of MAS, and its shortcomings. Findings – The paper recommends some further enhancements, and the use of care and caution when interpreting the metrics produced by cited reference

Péter Jacsó



Are You Ready to Go Digital?: The Pros and Cons of Electronic Portfolio Development  

ERIC Educational Resources Information Center

|There is an increasing need for educators to have professional portfolios, which are considered to be authentic tools for evaluating the knowledge, skill, beliefs and attitudes of prospective educators. Electronic portfolios are gaining in popularity and their relative pros and cons are examined.|

Heath, Marilyn



Quattordici Punti di accordo con i rapporti ufficiali governativi sulla distruzione del World Trade Center  

Microsoft Academic Search

I rapporti di FEMA e NIST contengono la versione ufficiale sulla distruzione del World Trade Center, avvenuta l'11 settembre 2001. In questa lettera vogliamo porre le basi per una discussione costruttiva e chiarificatrice, focalizzandoci sui punti di comune accordo con FEMA e NIST, e refutando nel contempo diverse credenze errate sui crolli del WTC. L'undici settembre 2001 le Torri Gemelle

Steven E. Jones; Frank M. Legge; Kevin R. Ryan; Anthony F. Szamboti; James R. Gourley


Evaluación del estado de salud con la Encuesta SF36: resultados preliminares en México  

Microsoft Academic Search

Objective. To establish a multidimensional profile of the health status in a population of southeastern Mexico and analyze the psychometric properties of a translation of the SF-36 survey authorized by the International Quality of Life Assessment Project. Material and methods. The SF-36 was administered to 257 volunteers of a clinic and a con- trol group in a governmental institution. The

Miguel A. Zúniga; Genny T. Carrillo-Jiménez; Peter J. Fos; Barbara Gandek; Manuel R. Medina-Moreno



Comparison of radiosensitivity of human lymphocytes stimulated with PHA Con A and PWM.  

National Technical Information Service (NTIS)

The transformation, DNA strand breaks and its repair ability in human peripheral blood lymphocytes stimulated with PHA, Con A and PWM were respectively assessed following exposure to (sup 60)Co gamma rays by (sup 3)H-thymidine uptake and hydroxylapatite c...

Y. Geng L. Su



Índice de Comportamiento Objetivo. Una medida para valorar la respuesta al tratamiento de pacientes con trastornos de personalidad graves  

Microsoft Academic Search

Una medida que capta la frecuencia e intensidad de comportamientos disfuncionales experimentados, así como el uso de los servicios de salud mental, se desarrollaron y probaron como parte de un ensayo de tratamiento controlado de pacientes con trastorno de personalidad borderline. El índice de comportamiento objetivo (ICO) se realizó con 136 individuos diagnosti- cados de trastorno de personalidad borderline antes

Heather Munroe-Blum; Lynn McClearly


76 FR 54533 - Pipeline Safety: Issuance of Draft Decision on GexCon US, Inc. Petition for Approval of Flame...  

Federal Register 2010, 2011, 2012, 2013

...Draft Decision on GexCon US, Inc. Petition for Approval of Flame Acceleration Simulator AGENCY: Pipeline and Hazardous Materials...Draft Decision on GexCon US, Inc.'s petition for approval of Flame Acceleration Simulator (FLACS). The Draft Decision is...



Railroad Accident Report - Rear End Collision of Two ConRail Freight Trains, Stemmers Run, Baltimore, Maryland, June 12, 1977.  

National Technical Information Service (NTIS)

About 11:03 p.m., on June 12, 1977, ConRail freight train WA-4 collided with the rear of ConRail freight train WA-6. A fire began in the lead locomotive unit of train WA-4 and in the caboose of train WA-6. Damage was about $300.000. Two crewmembers on eac...




Microsoft Academic Search

Resumen Objetivos: Explorar la hipótesis de que una personalidad de relaciones y de comunicación res- tringida, pérdidas personales penosas aunque no extraordinarias pero con incapacidad de afrontar positivamente las mismas, y una desmotivación plural persistente que se ensambla con un auto bloqueo perceptivo, constituyen una secuencia y un perfil peculiar de las personas que concluyen en Alzheimer, a dife- rencia



Probing of Brain States in Real-Time: Introducing the ConSole Environment  

PubMed Central

Recent years have seen huge advancements in the methods available and used in neuroscience employing EEG or MEG. However, the standard approach is to average a large number of trials for experimentally defined conditions in order to reduce intertrial-variability, i.e., treating it as a source of “noise.” Yet it is now more and more accepted that trial-to-trial fluctuations bear functional significance, reflecting fluctuations of “brain states” that predispose perception and action. Such effects are often revealed in a pre-stimulus period, when comparing response variability to an invariant stimulus. However such offline analyses are disadvantageous as they are correlational by drawing conclusions in a post hoc-manner and stimulus presentation is random with respect to the feature of interest. A more direct test is to trigger stimulus presentation when the relevant feature is present. The current paper introduces Constance System for Online EEG (ConSole), a software package capable of analyzing ongoing EEG/MEG in real-time and presenting auditory and visual stimuli via internal routines. Stimulation via external devices (e.g., transcranial magnetic stimulation) or third-party software (e.g., PsyScope X) is possible by sending TTL-triggers. With ConSole it is thus possible to target the stimulation at specific brain states. In contrast to many available applications, ConSole is open-source. Its modular design enhances the power of the software as it can be easily adapted to new challenges and writing new experiments is an easy task. ConSole is already pre-equipped with modules performing standard signal processing steps. The software is also independent from the EEG/MEG system, as long as a driver can be written (currently two EEG systems are supported). Besides a general introduction, we present benchmark data regarding performance and validity of the calculations used, as well as three example applications of ConSole in different settings. ConSole can be downloaded at:

Hartmann, Thomas; Schulz, Hannah; Weisz, Nathan



ConBr, a lectin from Canavalia brasiliensis seeds, protects against quinolinic acid-induced seizures in mice.  


Lectins are proteins capable of reversible binding to carbohydrates or glycoconjugates. In the central nervous system of mammals, lectins with affinity for mannose/glucose or galactose can modulate cellular communication. ConBr, a lectin isolated from the seeds of Canavalia brasiliensis, previously showed antidepressant effect in the forced swimming test in mice, with involvement of the monoaminergic system. In this study, we investigated the neuroprotective effects of ConBr against quinolinic acid (QA), a well-known NMDA agonist that produces severe neurotoxicity when administered in vivo. ConBr (10 ?g/site) administered via intracerebroventricular (i.c.v.) showed a neuroprotective activity against seizures induced by QA (36.8 nmol/site; i.c.v.) when administered 15 min prior to QA, with a percentage of protection around 50%. ConBr was also able to significantly decrease the severity of the seizures but without changes in the latency of the first convulsion or the duration of the seizures. This effect was dependent on the structural integrity of the ConBr protein and its binding capacity to oligosaccharides residues. ConA, a lectin with high similarity to ConBr, did not reverse the QA-induced seizures. Moreover, ConBr was able to protect against hippocampal cell death caused by QA, which was measured by propidium iodide incorporation. QA caused activation of JNK2 and improved the phosphorylation of Ser831 and 845 on the AMPA receptor GluR1 subunit, and both of these effects were counteracted by ConBr. Our data suggest that the lectin ConBr may exert a modulatory action on NMDA receptors, which inhibits its activity in response to QA. PMID:21948344

Russi, Michael A; Vandresen-Filho, Samuel; Rieger, Débora K; Costa, Ana Paula; Lopes, Mark W; Cunha, Rodrigo M S; Teixeira, Edson H; Nascimento, Kyria S; Cavada, Benildo S; Tasca, Carla I; Leal, Rodrigo B



Anticipated Stigma and Stigma Management Among Those to be Labeled “Ex-con  

Microsoft Academic Search

Male prisoners (n = 450) estimated public reaction to the label “ex-con” and endorsed likely stigma management strategies. Although most anticipate significant rejection, they prefer preventative telling to withdrawal and secrecy as adjustments. OLS regression finds factors promoting exclusion (devaluation\\/discrimination beliefs and reduced job opportunities) related to withdrawal and secrecy, whereas factors favoring inclusion (“wise” family and friends and plans to attend

Terri A. Winnick; Mark Bodkin



Effect of ConA-receptor interaction on the structure of cell membrane  

Microsoft Academic Search

Recently, the effect of ligand receptor interaction on the membrane structure of liposomes has been studied extensively. However, little is known about how it exists on biological membranes. In this paper, the effect of Concanavalin A (ConA) receptor interaction on the structure of cell membranes was studied by Circular Dichroism (CD) and 31P Nuclear Magnetic Resonance (NMR).CD results of both

Jianwu Dai; Qun Dong; Yaxian Su; Kechun Lin



Mound-ACT*DE*CON{sup SM} feasibility study. Phase 2: Final report  

SciTech Connect

A portion of the abandoned Miami-Erie Canal paralleling the Greater Miami River receives the runoff and storm-water discharge from Mound Laboratory. In 1969, a low-level plutonium leak contaminated sediment as far away as 1.5 mi from the Mound site along the old canal system. An estimated one million cubic feet of sediment requires remediation. The technology being evaluated for the remediation of the low-level plutonium-238 contamination of the sediment involves two processes: washing the sediments with ACT*DE*CON{sup SM} solution to dissolve the contaminant, followed by extraction of the solution and processing with the MAG*SEP{sup SM} process to concentrate the contaminant and allow reuse of the ACT*DE*CON{sup SM} solution. The processes are being optimized for pilot-scale and field demonstration. Phase 2 of the project primarily involved identification at the laboratory scale of the optimal ACT*DE*CON{sup SM} formulation, identification of the ion-exchanger and MAG*SEP{sup SM} particles, verification of the plutonium mobility in the treated soil, and evaluation of other process parameters according to a series of tasks.




Con_A-carbone nanotube conjugate with short wave near-infrared laser ablation for tumor therapy  

NASA Astrophysics Data System (ADS)

Using the characteristics of T cell mitogen called lectin protein from the jack-beam Canavalia ensiformis Concanavalin A (Con_A) with dual activities, cytotoxicity and immunomodulation, we have shown it has a therapeutic effect on hepatoma. Injection of Con_A can eradicate the established malign tumor, because Con_A can induce tumor cell autophagic, cell-programmed death, as well as activate the effector T cells. Combined, in this paper, with the absorption exceeding the Carbon NanoTube (CNT) band-gap (?bg=~1/CNT diameter) with an active short wave near-infrared (SWIR) (1.2~1.5 micron wavelengths), which happened to be translucent to the irradiation upon animal skin, similar to that used in hospital fingertip-clamped Pulse Oxymetry. Once the Con_ACNT is guided to hepatoma cells, it is bonded and internalized into the mitochondria (MC) compartment, the cellular energy factory. Con_A has the higher specificity for tumor cells useful for targeting because of the abnormal glycosylation on tumor cells. When CNT hitch hike with Con_A, they can t together like a laser-denotable chemical missile surgically targeting at the tumor cells precisely by Con_A-guidance. We switch on SWIR laser, when the Con_A-CNT conjugated complex has been bonded and internalized to MC of malign cells and already commenced cellular programmed death. Thus, it might appear to casual readers that we have initiated an overkill, chemical drugged autophage followed with physical laser ablation, but what if we can eradicate hepatoma totally if no blue print is left behind inadvertently in case of a partial failure. We conclude that using Con_A-CNT conjugated complex targeting specifically at malign tumor cells is a novel targeted-laser-radiation therapy for tumors in mice.

Lei, Huan-Yao; Peng, Ching-An; Tang, Ming-Jer; Reindhart, Kit; Szu, Harold H.



40 CFR 180.1213 - Coniothyrium minitans strain CON/M/91-08; exemption from the requirement of a tolerance.  

Code of Federal Regulations, 2013 CFR

...false Coniothyrium minitans strain CON/M/91-08; exemption from the requirement...1213 Coniothyrium minitans strain CON/M/91-08; exemption from the requirement...pesticide Coniothyrium minitans strain CON/M/91-08 when used in or on all food...



40 CFR 180.1213 - Coniothyrium minitans strain CON/M/91-08; exemption from the requirement of a tolerance.  

Code of Federal Regulations, 2010 CFR

...2009-07-01 false Coniothyrium minitans strain CON/M/91-08; exemption from the requirement...1213 Coniothyrium minitans strain CON/M/91-08; exemption from the requirement...pesticide Coniothyrium minitans strain CON/M/91-08 when used in or on all...



40 CFR 180.1213 - Coniothyrium minitans strain CON/M/91-08; exemption from the requirement of a tolerance.  

Code of Federal Regulations, 2010 CFR

...2010-07-01 false Coniothyrium minitans strain CON/M/91-08; exemption from the requirement...1213 Coniothyrium minitans strain CON/M/91-08; exemption from the requirement...pesticide Coniothyrium minitans strain CON/M/91-08 when used in or on all...




Microsoft Academic Search

Las habilidades sociales son un numeroso y variado conjunto de conductas que se ponen en juego en situaciones de interacción social, es decir, en situaciones en las que hay que relacionarse con otras personas. La Interacción social se refiere a las conductas necesarias para interactuar y relacionarse con los iguales y con los adultos de forma efectiva y mutuamente satisfactoria.

Elizabeth Gómez Núñez; Olga Lidia Núñez Rodriguez; Nemesio Jiménez Cepero; Ángel Luis Gómez Cardoso



Correlación entre la estructura de bandas y las propiedades físicas de óxidos cerámicos de estructura perovskita con metales de transición (I): Propiedades de conducción electrónica  

Microsoft Academic Search

En este artículo se revisa los principales modelos teóricos, que pretenden dar una explicación sobre las propiedades de con- ducción electrónica de óxidos cerámicos con estructura perovskita, que incluyen en la posición B metales de transición del primer período (Fe, Co, Ni, Mn), en conexión con su estructura de bandas y el carácter de sus electrones más externos, así como



Con A induction of IgG secretion from a B-lymphoid tumour cell line, A20.  

PubMed Central

We have examined the effect of concanavalin A (Con A), a conventionally known T-cell mitogen, on the induction of Ig secretion from BALB/c B lymphoid cell lines expressing membrane IgM (X16C8.5, BALENTL 17.7.2 and BCL1) or membrane IgG (A20 and M12.4). A20 tumour cells, but not other tumour cells, responded to Con A by secreting Ig as measured by the reverse plaque-forming cell (PFC) assay. Another typical T-cell mitogen, phytohaemagglutinin (PHA), did not have any effect on the differentiation of A20 tumour cells. The addition of NaN3 abolished the PFC formation, showing that IgG PFC formation of A20 tumour cells was due to the active synthesis of secreted IgG and not due to the shedding of mIgG. The increase in the biosynthesis of secreted IgG from A20 tumour cells by Con A was also observed by polyacrylamide gel electrophoresis. The ability of Con A to induce IgG secretion from A20 tumour cells was abolished by the addition of alpha-methylmannoside, confirming that Con A itself, and not some contaminating material in Con A, induced the maturation of A20 tumour cells. Con A was also shown to induce Ig secretion, but not proliferation, in a subset of normal B cells. Thus, we conclude that Con A does give a differentiation signal to a subset of B cells. Images Figure 2

Kim, K J; Dejoy, S Q



Con A induction of IgG secretion from a B-lymphoid tumour cell line, A20.  


We have examined the effect of concanavalin A (Con A), a conventionally known T-cell mitogen, on the induction of Ig secretion from BALB/c B lymphoid cell lines expressing membrane IgM (X16C8.5, BALENTL 17.7.2 and BCL1) or membrane IgG (A20 and M12.4). A20 tumour cells, but not other tumour cells, responded to Con A by secreting Ig as measured by the reverse plaque-forming cell (PFC) assay. Another typical T-cell mitogen, phytohaemagglutinin (PHA), did not have any effect on the differentiation of A20 tumour cells. The addition of NaN3 abolished the PFC formation, showing that IgG PFC formation of A20 tumour cells was due to the active synthesis of secreted IgG and not due to the shedding of mIgG. The increase in the biosynthesis of secreted IgG from A20 tumour cells by Con A was also observed by polyacrylamide gel electrophoresis. The ability of Con A to induce IgG secretion from A20 tumour cells was abolished by the addition of alpha-methylmannoside, confirming that Con A itself, and not some contaminating material in Con A, induced the maturation of A20 tumour cells. Con A was also shown to induce Ig secretion, but not proliferation, in a subset of normal B cells. Thus, we conclude that Con A does give a differentiation signal to a subset of B cells. PMID:3530982

Kim, K J; Dejoy, S Q



Effect of GonaCon™ vaccine on black-tailed prairie dogs: immune response and health effects.  


Management of prairie dogs in the past has included poisoning, fumigants, barriers, and relocation. Because of the diverse attitudes related to prairie dog management, nonlethal methods that allow the existence of prairie dogs but help minimize damage related to population growth need to be developed. GonaCon™ is an immunocontraceptive vaccine that elicits antibodies to native GnRH; this prevents the secretion of reproductive hormones necessary for sperm and oocyte production. Prairie dogs were vaccinated with 0.1, 0.2, or 0.4 mL of the GonaCon™ emulsion intramuscularly in the upper thigh containing 100, 200, or 400 ?g GnRH conjugate, respectively. Control animals were vaccinated with 0.4 mL saline emulsion in the upper thigh. Blood samples (?1 mL) were taken from the femoral vein once pretreatment and at 1, 2, 3, 4, 6, and 15 months post-vaccination. Age (adult or juvenile) did not affect immune response to GonaCon™. Antibody titers were higher in the 200 and 400 ?L GonaCon™ groups than in the 100 ?L group, and there was no difference between the 200 and 400 ?L GonaCon™ groups. No adverse effects of GonaCon™ were noted on weight or blood chemistry parameters during the study. GonaCon™ will likely contracept prairie dogs for ?1 year in the field using either 200 or 400 ?g conjugate. GonaCon™ could be incorporated into management plans to help maintain prairie dog populations while reducing habitat degradation due to overpopulation. PMID:21055491

Yoder, Christi A; Miller, Lowell A



ConMap: Investigating new computer-based approaches to assessing conceptual knowledge structure in physics  

NASA Astrophysics Data System (ADS)

There is a growing consensus among educational researchers that traditional problem-based assessments are not effective tools for diagnosing a student's knowledge state and for guiding pedagogical intervention, and that new tools grounded in the results of cognitive science research are needed. The ConMap (``Conceptual Mapping'') project, described in this dissertation, proposed and investigated some novel methods for assessing the conceptual knowledge structure of physics students. A set of brief computer-administered tasks for eliciting students' conceptual associations was designed. The basic approach of the tasks was to elicit spontaneous term associations from subjects by presenting them with a prompt term, or problem, or topic area, and having them type a set of response terms. Each response was recorded along with the time spent thinking of and typing it. Several studies were conducted in which data was collected on introductory physics students' performance on the tasks. A detailed statistical description of the data was compiled. Phenomenological characterization of the data (description and statistical summary of observed patterns) provided insight into the way students respond to the tasks, and discovered some notable features to guide modeling efforts. Possible correlations were investigated, some among different aspects of the ConMap data, others between aspects of the data and students' in-course exam scores. Several correlations were found which suggest that the ConMap tasks can successfully reveal information about students' knowledge structuring and level of expertise. Similarity was observed between data from one of the tasks and results from a traditional concept map task. Two rudimentary quantitative models for the temporal aspects of student performance on one of the tasks were constructed, one based on random probability distributions and the other on a detailed deterministic representation of conceptual knowledge structure. Both models were reasonably successful at approximating the statistical behavior of a typical student's data.

Beatty, Ian D.



Nitrogen-detected CAN and CON experiments as alternative experiments for main chain NMR resonance assignments  

PubMed Central

Heteronuclear direct-detection experiments, which utilize the slower relaxation properties of low ? nuclei, such as 13C have recently been proposed for sequence-specific assignment and structural analyses of large, unstructured, and/or paramagnetic proteins. Here we present two novel 15N direct-detection experiments. The CAN experiment sequentially connects amide 15N resonances using 13C? chemical shift matching, and the CON experiment connects the preceding 13C? nuclei. When starting from the same carbon polarization, the intensities of nitrogen signals detected in the CAN or CON experiments would be expected four times lower than those of carbon resonances observed in the corresponding 13C-detecting experiment, NCA-DIPAP or NCO-IPAP (Bermel et al. 2006b; Takeuchi et al. 2008). However, the disadvantage due to the lower ? is counteracted by the slower 15N transverse relaxation during detection, the possibility for more efficient decoupling in both dimensions, and relaxation optimized properties of the pulse sequences. As a result, the median S/N in the 15N observe CAN experiment is 16% higher than in the 13C observe NCA-DIPAP experiment. In addition, significantly higher sensitivity was observed for those residues that are hard to detect in the NCA-DIPAP experiment, such as Gly, Ser and residues with high-field C? resonances. Both CAN and CON experiments are able to detect Pro resonances that would not be observed in conventional proton-detected experiments. In addition, those experiments are free from problems of incomplete deuterium-to-proton back exchange in amide positions of perdeuterated proteins expressed in D2O. Thus, these features and the superior resolution of 15N-detected experiments provide an attractive alternative for main chain assignments. The experiments are demonstrated with the small model protein GB1 at conditions simulating a 150 kDa protein, and the 52 kDa glutathione S-transferase dimer, GST.

Takeuchi, Koh; Heffron, Gregory; Sun, Zhen-Yu J.; Frueh, Dominique P.



Lesbian (in)visibility in Italian Renaissance culture: Diana and other cases of donna con donna.  


Current conceptualizations of sexual identity in the West are not necessarily useful to an historian investigating "lesbianism" in the social history and visual representations of different periods. After an overview of Renaissance documents treating donna con donna relations which examines the potentially positive effects of condemnation and silence, the paper focuses on Diana, the goddess of chastity, who bathed with her nymphs as an exemplar of female bodies preserved for heterosexual, reproductive pleasures. Yet the self-sufficiency and bodily contact sometimes represented in images of this secluded all-female gathering might suggest "deviant" responses from their viewers. PMID:7798609

Simons, P



Cámara CCD Directa con el Telescopio de 2.15 m del CASLEO: algunos diagnósticos  

NASA Astrophysics Data System (ADS)

Se efectuaron algunas pruebas con la cámara CCD (+ Reductor Focal) instalada en el foco Cassegrain del Telescopio de 2.15 m del Complejo Astronómico El Leoncito (CASLEO). Las conclusiones más significativas son: Los tiempos de exposición efectivos difieren de los nominales en una fracción apreciable de segundo. En exposiciones de menos de 3 segundos, la iluminación no es pareja en todo el detector. En consecuencia, se recomiendan los pasos a seguir por los astrónomos tanto durante la observación como en la reducción de sus datos.

Cellone, S. A.


An aggregation of pro and con evidence for medical decision support systems.  


One promising way to increase the classification accuracy of medical decision support systems is to implement heuristic combinations of pattern recognition and artificial intelligence tools. A parallel between "cognition" model and differential diagnostic task is sketched accentuating the aggregation of activating and restraining inputs and corresponding PRO and CON evidence in medicine. On the basis of this paradigm a trainable model of a fuzzy neuron is proposed which resembles some elements from the physician's decision process. An example from aviation medicine is presented which demonstrates the enhanced performance. PMID:8306621

Kuncheva, L



Un estudio financiado por los Institutos Nacionales de la Salud (NIH) muestra reducción en la mortalidad entre hombres con cáncer de próstata en grado intermedio:

Terapia hormonal por corto tiempo administrada en combinación con radioterapia a hombres con cáncer de próstata en estadio inicial aumentó sus posibilidades de vivir más en comparación con tratamiento de radioterapia sola, según un estudio clínico patrocinado por el NCI. Los beneficios del tratamiento combinado se limitaron principalmente a pacientes con enfermedad de riesgo intermedio y no se observaron en hombres con cáncer de próstata de riesgo bajo, indican los investigadores.


Quick fix or long-term cure? Pros and cons of bariatric surgery  

PubMed Central

The past decade has seen an enormous increase in the number of bariatric, or weight loss, operations performed. This trend is likely to continue, mirroring the epidemic of obesity around the world and its rising prevalence among children. Bariatric surgery is considered by many to be the most effective treatment for obesity in terms of maintenance of long-term weight loss and improvement in obesity-related comorbid conditions. Although overly simplified, the primary mechanisms of the surgical interventions currently utilized to treat obesity are the creation of a restrictive or malabsorptive bowel anatomy. Operations based on these mechanisms include the laparoscopic adjustable gastric band and laparoscopic vertical sleeve gastrectomy (considered primarily restrictive operations), the laparoscopic biliopancreatic diversion with or without a duodenal switch (primarily malabsorptive operation), and the laparoscopic Roux-en-Y gastric bypass (considered a combination restrictive and selective malabsorptive procedure). Each operation has pros and cons. Important considerations, for the patient and surgeon alike, in the decision to proceed with bariatric surgery include the technical aspects of the operation, postoperative complications including long-term nutritional problems, magnitude of initial and sustained weight loss desired, and correction of obesity-related comorbidities. Herein, the pros and cons of the contemporary laparoscopic bariatric operations are reviewed and ongoing controversies relating to bariatric surgery are discussed: appropriate patient selection, appropriate operation selection for an individual patient, surgeon selection, and how to measure success after surgery.

Madura, James A.



Preparation of stimulus responsive multiple emulsions by membrane emulsification using con a as biochemical sensor.  


In this work, a novel strategy for the controlled fabrication of biomolecular stimulus responsive water-in-oil-in-water (W/O/W) multiple emulsion using the membrane emulsification process was investigated. The emulsions interface was functionalized with a biomolecule able to function as a receptor for a target compound. The interaction between the biomolecular receptor and target stimulus activated the release of bioactive molecules contained within the structured emulsion. A glucose sensitive emulsion was investigated as a model study case. Concanavalin A (Con A) was used as the biomolecular glucose sensor. Various physicochemical strategies for stimulus responsive materials formulation are available in literature, but the preparation of biomolecule-responsive emulsions has been explored for the first time in this paper. The development of novel drug delivery systems requires advanced and highly precise techniques to obtain their particular properties and targeting requirements. The present study has proven the flexibility and suitability of membrane emulsification for the preparation of stable and functional multiple emulsions containing Con A as interfacial biomolecular receptor able to activate the release of a bioactive molecule as a consequence of interaction with the glucose target molecule. The influence of emulsion interfacial composition and membrane emulsification operating conditions on droplets stability and functional properties have been investigated. The release of the bioactive molecule as a function of glucose stimulus and its concentration has been demonstrated. PMID:21404264

Piacentini, Emma; Drioli, Enrico; Giorno, Lidietta



[AnaConDa as last resort treatment. Case report of a chronic obstructive pulmonary disease].  


Treatment of patients suffering from decompensated chronic pulmonary disease (COPD) not responding to pharmacological therapy is still a major challenge in intensive care medicine. Administration of volatile anaesthetics may be a therapy of last resort in these cases. We report on a 65-year-old woman suffering from exacerbated COPD, who could not be sufficiently ventilated despite comprehensive pharmacological therapy. In order to administer a volatile anaesthetic in the ICU, we employed the "Anaesthetic Conserving Device" (AnaConDa) consisting of a vaporizer chamber embedded in a charcoal filter system. With this device, every standard intensive care ventilator can be used to deliver volatile anaesthetics in a safe and economic manner. The AnaConDa converts the open breathing system of the intensive care ventilator into a de facto half-closed system. The very low pulmonary compliance of the patient increased dramatically after administration of 0.75 vol% halothane for 48 h (27 vs. 150 ml/mbar). Elimination of CO(2) was improved and weaning from controlled ventilation was achieved. After surgical removal of a pulmonary abscess and a total of 78 days of intensive care therapy, the patient was discharged in good health. PMID:17375268

Nickel, E A; Benken, I; Bartels, U; Voelckel, W G; Quintel, M



Field performance of the RespiCon for size-selective sampling of industrial wood processing dust.  


The RespiCon sampler is a multistage virtual impactor that simultaneously collects the ISO/CEN/ACGIH size fractions of inhalable, thoracic, and respirable particulate matter. The field performance of the device for measurement of industrial wood processing dust was evaluated against reference size-selective samplers: the IOM sampler (inhalable dust), the GK 2.69 cyclone (thoracic dust), and the SKC aluminum cyclone (respirable dust). Seventy-one sets of area samples were collected from 10 wood processing plants, with the samplers mounted either in the free-field or on a two-dimensional bluff body. The geometric mean (range) dust levels across all plants measured by the reference samplers were: inhalable, 1.35 mg/ m3 (0.11-11.06); thoracic, 0.31 mg/m3 (0.05-1.38); and respirable, 0.10 mg/m3 (0.02-0.54). In comparing the RespiCon with the reference samplers, there was no significant difference between sampling in the free-field versus bluff-body modes. For inhalable dust, there was no significant difference between the RespiCon and the IOM sampler after applying a correction factor of 1.5 to the extrathoracic data obtained from the RespiCon. Without the correction factor, the RespiCon undersample inhalable dust by an average of 23%. For thoracic dust, the RespiCon was shown to oversample the extrathoracic dust fraction resulting in an overall error of 48%. A simple correction based on the inhalable and thoracic dust levels reported by the RespiCon is proposed. For respirable dust, there was a significant difference between the RespiCon and the SKC cyclone, but the data were equivocal due to imprecision in measurement of the low respirable dust concentrations encountered and the likelihood of bias in the reference sampler. Overall, the RespiCon sampler appears to be a suitable size-selective sampling device for industrial wood processing dust, although adjustments should be made to the inhalable and thoracic dust results. PMID:15788383

Rando, Roy; Poovey, Halet; Mokadam, Dinkar; Brisolara, Joseph; Glindmeyer, Henry



A con-focal setup for micro-XRF experiments using diamond anvil cells  

NASA Astrophysics Data System (ADS)

In this contribution we introduce an experimental setup to perform con-focal micro X-ray fluorescence measurements in situ in samples at high temperatures and pressures in diamond anvil cells (DAC) (e.g. Schmidt et al. 2007). The con-focal arrangement is used to suppress the background in X-ray fluorescence (XRF) spectra that stems from elastic and inelastic scattering of the diamond anvils. The setup is based on a focusing optic in the incident beam that reaches a spot of 5-10 ?m and a focusing poly-capillary in front of an energy-dispersive solid-state detector. The detector poly-capillary is designed to work at a very long working distance of 50 mm in order to collect the radiation from the center of the DAC at 90° to the incident beam. The probing volume is defined by the two foci and has a size of ca. 300 ?m at 8 keV and 150 ?m at 19 keV as measured by scans through thin metal foils. Comparison of XRF spectra acquired with a usual detector collimator and spectra recorded with the detector capillary shows a strong suppression of XRF signal generated outside the probed volume, i.e. XRF from the gasket material and signal from elastic and Compton scattering by the diamond anvils. The ratio of the Zr K-alpha fluorescence peak to the peak of the Compton scattering changes from 0.5 (collimator) to 1.26 (detector capillary) for a ca. 1000 ppm Zr standard solution and an incident beam energy of 20 keV. For a standard solution containing ca. 1000 ppm Hf, the ratio of the L-alpha to the Compton signal increases to 6 using the detector capillary and an incident beam energy of 9.7 keV. Thus, the con-focal setup substantially improves the fluorescence to background ratio. This will result in higher sensitivities for dilute elements in the sample chamber of the DAC. Furthermore, the possibilities of interference of the sample's signal with signal from the sample environment are greatly reduced. In a broader sense, the setup can also be applied to other confined samples that require long working distances. Schmidt et al. (2007) Lithos 95, 87-102

Wilke, Max; Rickers, Karen; Vincze, Laszlo; Schmidt, Christian; Borchert, Manuela; Pascarelli, Sakura



Multi-wall carbon nanotube-polyaniline biosensor based on lectin-carbohydrate affinity for ultrasensitive detection of Con A.  


In this paper, a novel method for detecting concanavalin A (Con A) was developed based on lectin-carbohydrate biospecific interactions. Multi-wall carbon nanotube-polyaniline (MWNT-PANI) nanocomposites, synthesized by in situ polymerization, were chosen to immobilize d-glucose through the Schiff-base reaction. The immobilized D-glucose showed high binding sensitivity and excellent selectivity to its target lectin, Con A. Cyclic voltammetry (CV), electrochemical impedance spectroscopy (EIS), transmission electron microscopy (TEM) and atomic force microscopy (AFM) were applied to characterize the assembly process of the modified electrode. Due to the high affinity of Con A for D-glucose and high stability of the propounded sensing platform, the fabricated biosensor achieved ultrasensitive detection of Con A with good sensitivity, acceptable reproducibility and stability. The changes of response current were proportional to the Con A concentrations from 3.3 pM to 9.3 nM, with a detection limit of 1.0 pM. Therefore, the combination of MWNT-PANI nanocomposites and the special binding force between lectin and carbohydrate provides an efficient and promising platform for the fabrication of bioelectrochemical devices. PMID:22387041

Hu, Fangxin; Chen, Shihong; Wang, Chengyan; Yuan, Ruo; Xiang, Yun; Wang, Cun



Methane activation by cobalt cluster cations, Con+ (n=2-16): Reaction mechanisms and thermochemistry of cluster-CHx (x=0-3) complexes  

NASA Astrophysics Data System (ADS)

The kinetic energy dependences of the reactions of Con+ (n=2-16) with CD4 are studied in a guided ion beam tandem mass spectrometer over the energy range of 0-10 eV. The main products are hydride formation, ConD+, dehydrogenation to form ConCD2+, and double dehydrogenation yielding ConC+. These primary products decompose to form secondary and higher order products, ConCD+, Con-1D+, Con-1C+, Con-1CD+, and Con-1CD2+ at higher energies. Adduct formation of ConCD4+ is also observed for the largest cluster cations, n>=10. In general, the efficiencies of the single and double dehydrogenation processes increase with cluster size, although the hexamer cation shows a reduced reactivity compared to its neighbors. All reactions exhibit thresholds, and cross sections for the various primary and secondary reactions are analyzed to yield reaction thresholds from which bond energies for cobalt cluster cations to D, C, CD, CD2, and CD3 are determined. The relative magnitudes of these bond energies are consistent with simple bond order considerations. Bond energies for larger clusters rapidly reach relatively constant values, which are used to estimate the chemisorption energies of the C, CD, CD2, and CD3 molecular fragments to cobalt surfaces.

Citir, Murat; Liu, Fuyi; Armentrout, P. B.



Pro-Con Debate: Etomidate or Ketamine for Rapid Sequence Intubation in Pediatric Patients  

PubMed Central

When caring for critically ill children, airway management remains a primary determinant of the eventual outcome. Airway control with endotracheal intubation is frequently necessary. Rapid sequence intubation (RSI) is generally used in emergency airway management to protect the airway from passive regurgitation of gastric contents. Along with a rapid acting neuromuscular blocking agent, sedation is an essential element of RSI. A significant safety concern regarding sedatives is the risk of hypotension and cardiovascular collapse, especially in critically ill patients or those with pre-existing comorbid conditions. Ketamine and etomidate, both of which provide effective sedation with limited effects on hemodynamic function, have become increasingly popular as induction agents for RSI. However, experience and clinical investigations have raised safety concerns associated with both etomidate and ketamine. Using a pro-con debate style, the following manuscript discusses the use of ketamine versus etomidate in RSI.

Scherzer, Daniel; Leder, Mark; Tobias, Joseph D.



Intramolecular Hydrogen Bond in Alkoxyamines. Influence on the C-ON Bond Homolysis.  


The C-ON bond homolysis in alkoxyamines can be influenced by the presence of an intramolecular hydrogen bond (IHB) between the alkyl and the nitroxyl fragments, which leads to an 8-fold decrease in the homolysis rate constant kd. When the IHB is disrupted by the solvent or by substitution of the hydrogen involved in the IHB by a protecting group (OMe, OAc, OBz, OBn, or OTBDMS), a higher homolysis rate constant kd is observed, as expected from the correlations developed by Marque ( Bertin , D. ; Gigmes , D. ; Marque , S. ; Tordo , P. Macromolecules 2005 , 38 , 2638 - 2650 ). Results were confirmed by DFT calculations at the B3LYP/6-31G(d,p) level. PMID:24070391

Brémond, Paul; Butscher, Teddy; Roubaud, Valérie; Siri, Didier; Viel, Stéphane



A maritime navigation display that provides visual feedback to improve conning officers' ship-handling during low visibility environments.  


Navigating a ship at night in close proximity to another vessel is a dangerous task. To improve conning officers' night time ship-handling performance, a visual navigation display is proposed that is mounted on the stern of the aircraft carrier that will help shipboard conning officers manoeuvre in a battle group formation. To test the effectiveness of the visual navigation display, the Nimitz-class aircraft and plane guard vessel, a Ticonderoga-class cruiser, were modelled in a virtual environment. A navigation display condition had significantly fewer navigational positional errors than a non-navigation display condition. The navigation display provided immediate feedback as to whether the aircraft carrier had changed bearing or speed, thus enabling the operator to initiate the appropriate input to maintain station astern of the carrier. Actual or potential applications of this research include the deployment of a maritime navigation display to assist conning officers' ship handling. PMID:12569043

Evanoff, Thomas V; Krebs, William K



Direct activation of murine resting T cells by con A or anti-CD3 Ig.  


The induction of antigen-specific T cell activation is highly dependent on accessory cells (AC) which present processed antigenic fragments associated with MHC molecules and provide costimulatory signals for T cells. Antigen-specific T cell activation requires cross-linking of the TCR and the reception of one or more nonantigen-specific signals which eventually lead to T cell activation and proliferation. This sequence of events can be mimicked by lectins, bacterial enterotoxins, and anti-TCR antibodies in conjunction with APC or the combination of phorbol esters and Ca ionophores. Although the combination of PMA + Ca ionophore and certain types of T-T interactions result in APC independent T cell activation, it is generally assumed that physiologic T cell activation requires APC. The seemingly direct activation of T cells by other T cells is rather surprising in view of the known APC dependence of antigen, lectin and anti-TCR mediated T cell activation. It is conceivable that T cell mediated T cell activation is due to "cryptic" APC contamination because the total absence of APC is difficult to disprove. In reality, neither total depletion nor residual contamination with APC can be proven or disproven experimentally. Thus it can be legitimately argued that both APC dependent and independent T cell activation occur, albeit under different experimental conditions. For instance, it is possible that APC independent activation of T cells by lectins and anti-TCR antibodies would require high concentrations of activators to overide their dependence on APC. It is also conceivable and, in our opinion quite likely, that once activated, T cells could propagate T cell activation through T-T interactions. In this report we test two hypotheses: (1) The triggering of resting T cells leading to autocrine cell proliferation depends entirely on cross-linking TCR molecules, and (2) The presence of activated T cells facilitates TCR mediated activation of resting T cells without the participation of conventional APC. We present evidence that highly purified, small resting T cells can be reproducibly activated with high doses of ConA, plastic bound anti-CD3 mab and its F(ab')2 fragments. This APC independent response results in blastic transformation, expression of the IL2 Receptor, the secretion of IL2 and significant proliferation of both CD4+ and CD8+ murine T cells. These observations demonstrate that vigorous cross-linking of TCRs by anti-CD3 mab and, presumably ConA, is sufficient to induce T cell activation and autocrine (IL2 driven) proliferation.(ABSTRACT TRUNCATED AT 400 WORDS) PMID:2532886

Quintáns, J; Yokoyama, A; Evavold, B; Hirsch, R; Mayforth, R D



Contaminantes atmosféricos y su correlación con infecciones agudas de las vías respiratorias en niños de Guadalajara, Jalisco  

Microsoft Academic Search

Objective: To describe the correlation between the con- centration levels of atmospheric air pollutants and the num- ber of medical visits to IMSS, ISSSTE and of SSJ healthcare facilities of the Urban Area of Guadalajara between 2000- 2002 by children under five years suffering from acute res- piratory infections. Material and Methods: An ecological study was performed to describe the

Hermes Ulises Ramírez-Sánchez; María Dolores Andrade-García; Miguel Ernesto González-Castañeda; Alfredo de Jesús Celis-de la Rosa



Con-A-CNT (Carbon Nanotube) Conjugate with Short Wave Near-Infrared (SWIR) Laser Ablation for Tumor Therapy.  

National Technical Information Service (NTIS)

Using the characteristics of T cell mitogen called lectin protein from the jack-bean Canavalia ensiformis Concanavalin A (Con-A) with dual activities, cytotoxicity and immunomodulation, we have shown it has a therapeutic effect on hepatoma. Injection of C...

C. Peng H. Lei H. Szu M. Tang



The pros and cons of distant pedicled flaps for upper extremity trauma reconstruction in the era of microvascular surgery  

Microsoft Academic Search

Nineteen distant pedicled flaps, performed during 1989 for posttraumatic upper extremity soft tissue defect cover were reviewed. The pros and cons of distant pedicled flaps were examined with respect to the alternative treatment; namely, free microvascular tissue transfer. The main points considered were the traumatic defect, the donor site and particular problems of each patient. The conclusion was that pedicled

P. Graft; H. U. Steinau; G. Ingianni; E. Biemer



Considerazioni sulla proprieta' insulino-legante del siero del soggetto normale e del diabetico mai trattato con insulina  

Microsoft Academic Search

Riassunto Gli AA. rilevano che i sieri dell'individuo normale e del diabetico mai trattato con insulina sono provvisti di proprietà insulino-legante di entità analoga. In alcuni sieri, sia del soggetto normale che del diabetico, è presente un'attività insulino-legante superiore ai valori massimi normali, che diminuisce dopo aggiunta di µU 500 di insulina bovina.

Michele Lunetta; Giuseppe Calcagno; Luciano Motta; Turiddu Lombardo



Treatment of plutonium contaminated soil/sediment from the Mound site using the ACT*DE*CON{sup SM} process  

SciTech Connect

The removal and/or treatment of contaminated soil is a major problem facing the US DOE. The EG&G Mound Applied Technologies site in Miamisburg, Ohio, has an estimated 1.5 million cubic feet of soils from past disposal and waste burial practices awaiting remediation from plutonium contamination. This amount includes sediment from the Miami-Erie Canal that was contaminated in 1969 following a pipe- rupture accident. Conventional soil washing techniques that use particle separation would generate too large a waste volume to be economically feasible. Therefore, innovative technologies are needed for the cleanup. The ACT*DE*CON process was developed by SELENTEC for washing soils to selectively dissolve and remove heavy metals and radionuclides. ACT*DE*CON chemically dissolves and removes heavy metals and radionuclides from soils and sediments into an aqueous medium. The ACT*DE*CON process uses oxidative carbonate/chelant chemistry to dissolve the contaminant from the sediment and hold the contaminant in solution. The objective of recent work was to document the proves conditions necessary to achieve the Mound-site and regulatory-cleanup goals using the ACT*DE*CON technology.

Negri, M.C. [Argonne National Lab., IL (United States); Swift, N.A. [SELENTEC, Atlanta, GA (United States); North, J.P. [Rust Remedial Service, Inc., Anderson, SC (United States)



Juvenile Survival and Development in Euseius Finlandicus, Typhlodromus Pyri and Kampimodromus Aberrans (Acari: Phytoseiidae) Feeding on Con and Heterospecific Immatures  

Microsoft Academic Search

Juvenile survival and development in Euseius finlandicus (Oudemans), Typhlodromus pyri Scheuten and Kampimodromus aberrans (Oudemans) feeding on con- and heterospecific phytoseiid immatures were investigated in the laboratory at 25 ± 1 °C and 65 ± 5% RH. More than 50% of T. pyri protonymphs preying on larvae of K. aberrans or E. finlandicus reached the adult stage. The mean developmental

Peter Schausberger



Mecanismos psicofisiológicos implicados en la regulación afectiva y la restricción alimentaria de mujeres con riesgo de padecer bulimia nerviosa  

Microsoft Academic Search

El objetivo del estudio fue conocer el efecto de visualizar imágenes de comida bajo diferentes estados de ánimo y diferentes condiciones de restricción alimentaria en la modulación emocional de dos refle- jos defensivos (sobresalto motor y defensa cardiaca). 72 mujeres con riesgo de padecer bulimia ner- viosa fueron asignadas a dos grupos: 1) un grupo al que se inducía un

Sonia Rodríguez; José Luis Mata; Silvia Moreno; Jaime Vila




Microsoft Academic Search

El objeto del presente estudio es evaluar las diferencias en el gasto energético en la práctica de actividad física durante la jornada escolar y durante los fines de semana, y su relación con la autoestima en chicas adolescentes. Participaron 175 chicas entre 11 y 16 años, que cumplimentaron la Escala de Autoestima de Rosenberg, la Escala de Habilidad Física Percibida

Molinero González; Martínez García; Martín Ardura; M. Bragança; Salguero del Valle; Márquez Rosa


Present-day stress and pore pressure fields in the Cuu Long and Nam Con Son Basins, offshore Vietnam  

Microsoft Academic Search

Knowledge of the in situ, or contemporary stress field is vital for planning optimum orientations of deviated and horizontal wells, reservoir characterization and a better understanding of geodynamic processes and their effects on basin evolution.This study provides the first documented analysis of in situ stress and pore pressure fields in the sedimentary formations of the Cuu Long and Nam Con

Nguyen Thi Thanh Binh; Tomochika Tokunaga; Hoang Phuoc Son; Mai Van Binh



The use of the Pros and Cons of Anorexia Nervosa (P-CAN) Scale with children and adolescents  

Microsoft Academic Search

Objective: The Pros and Cons of Anorexia Nervosa (P-CAN) Scale was developed out of a previous qualitative study [Int J Eat Disord 25 (1999) 177] in which the positive and negative aspects of anorexia nervosa (AN) were elicited from individuals with AN. Principal components analysis was then used in an adult sample to reduce the number of items and to

Lucy Serpell; Marc Neiderman; Emma Haworth; Francesca Emmanueli; Bryan Lask



Strains arising by seismic events in the SIRGAS-CON network region  

NASA Astrophysics Data System (ADS)

In this study, we investigate surface strains related to seismic events and their relationship with pre- and post-seismic events in Latin America, by analyzing the variation of estimated earth coordinates supplied by a geodetic network called SIRGAS-CON. Based on data provided by the USGS for the period 2000-2011, and after the Global Congruency test, we selected four events associated with unstable geodetic network points. The resulting strains were estimated based on the finite element method using networks of points considered unstable connected to neighboring points using the Delaunay triangulation. It was possible to determine the strains along with the resulting guidelines for pre- and post-seismic, considering each triangular lattice formed for analysis as a homogeneous solid body. The calculation of strains and verification of the results allowed to analyze the interactions between lithospheric plates from the contraction and extension directions between points located in different plates. Despite the association between seismic events and the strain of geodetic network, some events of magnitude greater than 5.8 Mw were excluded because it does not show (provide) the surface strain, which is located at great depths. It was confirmed that events of greater magnitude provide increased surface strain rate when compared with other similar depths.

Marotta, G. S.; França, G. S.; Monico, J. F. G.; Fuck, R. A.



Long-Acting Injectable Antipsychotics for First-Episode Schizophrenia: The Pros and Cons  

PubMed Central

Clinical and psychosocial deterioration associated with schizophrenia occurs within the first few years following the onset of the illness. Therefore, to improve the long-term prognosis, it is important to provide schizophrenia patients with intensive treatment following their first episode. Relapse is highly associated with partial medication adherence or nonadherence in patients with first-episode schizophrenia. Recent studies suggest that long-acting injectable (LAI) antipsychotics compared with oral antipsychotics are more effective for medication adherence and relapse prevention. Moreover, some clinical guidelines for the treatment of schizophrenia suggested that LAI antipsychotics should be considered when patients are nonadherent “at any stage.” Decreased compliance is a common cause of relapse during the initial stages of the disease. Therefore, LAI antipsychotics should be highly considered when treating patients with first-episode schizophrenia. In the present paper, clinical trial data and current guidelines on the use of LAI antipsychotics for first-episode schizophrenia are discussed as well as the pros and cons of this treatment option.

Kim, Borah; Lee, Sang-Hyuk; Yang, Yen Kuang; Park, Jong-Il; Chung, Young-Chul



Pro con debate: the use of regional vs systemic analgesia for neonatal surgery.  


In recent years the inclusion of regional techniques to pediatric anesthesia has transformed practice. Simple procedures such as caudal anesthesia with local anaesthetics can reduce the amounts of general anesthesia required and provide complete analgesia in the postoperative period while avoiding large amounts of opioid analgesia with potential side effects that can impair recovery. However, the application of central blocks (epidural and spinal local anesthesia) via catheters in the younger infant, neonate and even preterm neonate remains more controversial. The potential for such invasive maneuvers themselves to augment risk, can be argued to outweigh the benefits, others would argue that epidural analgesia can reduce the need for postoperative ventilation and that this not only facilitates surgery when intensive care facilities are limited, but also reduces cost in terms of PICU stay and recovery profile. Currently, opinions are divided and strongly held with some major units adopting this approach widely and others maintaining a more conservative stance to anesthesia for major neonatal surgery. In this pro-con debate the evidence base is examined, supplemented with expert opinion to try to provide a balanced overall view. PMID:21722227

Bösenberg, Adrian T; Jöhr, Martin; Wolf, Andrew R



[Emission spectrum of liquid CO-N2 mixture at shock compression].  


Driving a copper projectile to impact a cryo-target made of aluminous alloy at the speed of 2.21 km x s(-1) with a two stage light gas gun, a proper one dimensional shockwave with a speed of 18.76 km x s(-1) was generated and directly acted on a uniform liquid in target, which was condensed by proportional gaseous carbon monoxide and nitrogen. At the measurement of Hugoniots, the full linear spectrum entirely dissociated with the plasma under the shock pressure of 33.5 GPa was caught by the use of intensified charge coupled device and accurate spectrographic technology. From the analysis of the spectrum, the authors know that the transient spectrograph with six channels can be used to measure and record the course of shock compression-irradiancy reliably, and the emitted spectral lines of shock compressed products indicated that the thermal dissociation and phase transition had occurred in homogeneous liquid of CO-N2. Furthermore, comparing the spectral intensity of lower central wavelength with that of higher, the fact of stronger intensity of 488 nm also validates that changes from "optic thin" to "optic thick" exist indeed in dense hydrocarbon liquid acted on by shock pressure. PMID:19626860

Sun, Yue; Yi, Peng-Fei; Chen, Xian-Meng; Liu, Fu-Sheng; Zhang, Ming-Jian; Zheng, Xue-Ping; Xue, Xue-Dong



Chemically triggered C-ON bond homolysis in alkoxyamines: regioselectivity and chemoselectivity.  


Recently, we examplified the activation of the C-ON bond homolysis by protonation, alkylation, benzylation, acylation, oxidation and complexation with a Lewis acid of the nitrogen atom of the 1-(pyridin-4-yl)ethyl fragment (Chem. Commun., 2011, 4291 and Org. Lett., 2012, 358) and of the 1-(pyridin-2-yl)ethyl fragment (J. Org. Chem. ASAP Doi:10.1021/jo401674v) of (N-(2-methylpropyl)-N-(1-diethylphosphono-2,2-dimethylpropyl)-N-oxyl) SG1-based alkoxyamines. The quaternization of the 1-(pyridin-3-yl)ethyl fragment by the aforementioned reactions was investigated for the corresponding SG1-based alkoxyamines. In sharp contrast to the quaternization at ortho and para positions of the pyridyl moiety, the effect of the quaternization at the meta position was weak. The effects of quaternization at ortho, meta and para positions were investigated through natural bond orbital and Mulliken charges, HOMO-LUMO interactions in the starting materials and the radical stabilization energy of the released 1-puridylmethyl radicals using DFT calculations with the B3LYP/6-31G(d) and UBMK/6-311+G(3df,2p)//R(O)B3LYP/6-31G(d) methods, respectively. PMID:24114038

Audran, Gérard; Brémond, Paul; Ibanou, Matisse Bim Batsiandzy; Marque, Sylvain R A; Roubaud, Valérie; Siri, Didier




Microsoft Academic Search

. La fotocorriente inducida por iluminación pulsada, de un capacitor MOS con compuerta de Mo, provisto de ventana óptica, se emplea como monitor de su estado de carga, frente a estímulos químicos con concentraciones crecientes de H2 en N2 de hasta 1000 ppm. Se describen las respuestas inducidas por transporte a la interfaz metal-dieléctrico. Los resultados confirman que la sensibilidad

R. M. Lombardi; R. Aragón


Do Patient-perceived Pros and Cons of Opioids Predict Sustained Higher-Dose Use?  


OBJECTIVES:: Chronic opioid therapy (COT) is associated with various adverse outcomes, especially at higher doses, yet little is known about predictors of sustained higher-dose COT. This study aimed to ascertain, among higher-dose COT patients, the association of patient-perceived pros and cons of opioids with continued higher-dose use 1 year later. METHODS:: Patients (N=1229) in 2 large health plans prescribed ?50 mg morphine-equivalent dose (MED) per day for chronic noncancer pain completed a survey assessing opioid benefits and harms. The Prescribed Opioid Difficulties Scale questionnaire assessed psychosocial problems, concerns, benefits, and side effects related to opioid use. Logistic regression models estimated the associations of the reported benefits and problems with higher-dose continuation (?50 mg MED/d) versus dose reduction (<50 mg MED/d) 1 year later. RESULTS:: Over 80% of participants continued higher-dose opioid use at 1 year, regardless of reported problems, concerns, side effects, pain reduction, or perceived helpfulness. Higher scores on the Prescribed Opioid Difficulties Scale Problems subscale (odds ratio=0.79, 95% confidence interval, 0.68-0.92) and Concerns subscale (odds ratio=0.76, 95% confidence interval, 0.65-0.90) were negatively associated with higher-dose use 1 year later. Other baseline measures (opioid helpfulness, reduction in pain, number of side effects, and side effect bothersomeness) were not significantly associated with continued higher-dose use. DISCUSSION:: The large majority of patients continued using higher-dose opioids regardless of baseline characteristics. These findings suggest the difficulty of reducing opioid dose among chronic higher-dose opioid users. PMID:23535150

Thielke, Stephen M; Turner, Judith A; Shortreed, Susan M; Saunders, Kathleen; Leresche, Linda; Campbell, Cynthia I; Weisner, Constance C; Korff, Michael Von



Strain rate of the South American lithospheric plate by SIRGAS-CON geodetic observations  

NASA Astrophysics Data System (ADS)

A multiyear solution of the SIRGAS-CON network was used to estimate the strain rates of the earth surface from the changing directions of the velocity vectors of 140 geodetic points located in the South American plate. The strain rate was determined by the finite element method using Delaunay triangulation points that formed sub-networks; each sub-network was considered a solid and homogeneous body. The results showed that strain rates vary along the South American plate and are more significant on the western portion of the plate, as expected, since this region is close to the subduction zone of the Nazca plate beneath the South American plate. After using Euler vectors to infer Nazca plate movement and to orient the velocity vectors of the South American plate, it was possible to estimate the convergence and accommodation rates of the Nazca and South American plates, respectively. Strain rate estimates permitted determination of predominant contraction and/or extension regions and to establish that contraction regions coincide with locations with most of the high magnitude seismic events. Some areas with extension and contraction strains were found to the east within the stable South American plate, which may result from different stresses associated with different geological characteristics. These results suggest that major movements detected on the surface near the Nazca plate occur in regions with more heterogeneous geological structures and multiple rupture events. Most seismic events in the South American plate are concentrated in areas with predominant contraction strain rates oriented northeast-southwest; significant amounts of elastic strain can be accumulated on geological structures away from the plate boundary faults; and, behavior of contractions and extensions is similar to what has been found in seismological studies.

Marotta, Giuliano Sant'Anna; França, George Sand; Galera Monico, João Francisco; Fuck, Reinhardt Adolfo; Oswaldo de Araújo Filho, José



Iliac crest autograft versus alternative constructs for anterior cervical spine surgery: Pros, cons, and costs  

PubMed Central

Background: Grafting choices available for performing anterior cervical diskectomy/fusion (ACDF) procedures have become a major concern for spinal surgeons, and their institutions. The “gold standard”, iliac crest autograft, may still be the best and least expensive grafting option; it deserves to be reassessed along with the pros, cons, and costs for alternative grafts/spacers. Methods: Although single or multilevel ACDF have utilized iliac crest autograft for decades, the implant industry now offers multiple alternative grafting and spacer devices; (allografts, cages, polyether-etherketone (PEEK) amongst others). While most studies have focused on fusion rates and clinical outcomes following ACDF, few have analyzed the “value-added” of these various constructs (e.g. safety/efficacy, risks/complications, costs). Results: The majority of studies document 95%-100% fusion rates when iliac crest autograft is utilized to perform single level ACDF (X-ray or CT confirmed at 6-12 postoperative months). Although many allograft studies similarly quote 90%-100% fusion rates (X-ray alone confirmed at 6-12 postoperative months), a recent “post hoc analysis of data from a prospective multicenter trial” (Riew KD et. al., CSRS Abstract Dec. 2011; unpublished) revealed a much higher delayed fusion rate using allografts at one year 55.7%, 2 years 87%, and four years 92%. Conclusion: Iliac crest autograft utilized for single or multilevel ACDF is associated with the highest fusion, lowest complication rates, and significantly lower costs compared with allograft, cages, PEEK, or other grafts. As spinal surgeons and institutions become more cost conscious, we will have to account for the “value added” of these increasingly expensive graft constructs.

Epstein, Nancy E.



Plasmonic tunable glucose sensing based on the dissociation of Con A-aggregated dextran-coated gold colloids  

NASA Astrophysics Data System (ADS)

We have recently developed a new approach to glucose sensing based on the aggregation of nanometer-sized noble-metal nanoparticles and their respective change in plasmon absorption upon glucose addition. High molecular weight Dextran coated nanoparticles are aggregated with Concanavalin A, (Con A), where the aggregation results in a significant shift in metal-plasmon absorption. The addition of glucose competitively binds to Con A, reducing nanoparticle aggregation, and therefore the plasmon absorption when monitored at 650 nm. We have optimized our plasmonic glucose sensing mechanism with regard to nanoparticle stability, the dynamic range for glucose sensing and the wavelength of observation, to be compatible with both clinical glucose requirements and measurements.

Geddes, Chris D.; Aslan, Kadir; Zhang, Jian; Lakowicz, Joseph R.



Structural analysis of ConBr reveals molecular correlation between the carbohydrate recognition domain and endothelial NO synthase activation.  


Diocleinae lectins are highly homologous in their primary structure which features metal binding sites and a carbohydrate recognition domain (CRD). Differences in the biological activity of legume lectins have been widely investigated using hemagglutination inhibition assays, isothermal titration microcalorimetry and co-crystallization with mono- and oligosaccharides. Here we report a new lectin crystal structure (ConBr) extracted from seeds of Canavalia brasiliensis, predict dimannoside binding by docking, identify the ?-aminobutyric acid (Abu) binding pocket and compare the CRD of ConBr to that of homologous lectins. Based on the hypothesis that the carbohydrate affinity of lectins depends on CRD configuration, the relationship between tridimensional structure and endothelial NO synthase activation was used to clarify differences in biological activity. Our study established a correlation between the position of CRD amino acid side chains and the stimulation of NO release from endothelium. PMID:21530490

Bezerra, Eduardo Henrique Salviano; Rocha, Bruno Anderson Matias; Nagano, Celso Shiniti; Bezerra, Gustavo de Arruda; Moura, Tales Rocha de; Bezerra, Maria Júlia Barbosa; Benevides, Raquel Guimarães; Sampaio, Alexandre Holanda; Assreuy, Ana Maria Sampaio; Delatorre, Plínio; Cavada, Benildo Sousa



Long-Term Efficacy and Reproductive Behavior Associated with GonaCon ? Use in White-Tailed Deer (Odocoileus virginianus )  

Microsoft Academic Search

GonaCon ? is a single-shot immunocontraceptive vaccine that targets the reproductive hormone gonadotropin releasing hormone (GnRH). The GnRH peptide used in the vaccine is secreted by the hypothalamus of the brain and is specifically known as luteinizing hormone releasing hormone. This peptide stimulates the synthesis and secretion of luteiniz- ing hormone and follicle stimulating hormone by the anterior pituitary gland.

Gary Killian


Comparison of four probabilistic models (CARES(®), Calendex™, ConsExpo, and SHEDS) to estimate aggregate residential exposures to pesticides.  


Two deterministic models (US EPA's Office of Pesticide Programs Residential Standard Operating Procedures (OPP Residential SOPs) and Draft Protocol for Measuring Children's Non-Occupational Exposure to Pesticides by all Relevant Pathways (Draft Protocol)) and four probabilistic models (CARES(®), Calendex™, ConsExpo, and SHEDS) were used to estimate aggregate residential exposures to pesticides. The route-specific exposure estimates for young children (2-5 years) generated by each model were compared to evaluate data inputs, algorithms, and underlying assumptions. Three indoor exposure scenarios were considered: crack and crevice, fogger, and flying insect killer. Dermal exposure estimates from the OPP Residential SOPs and the Draft Protocol were 4.75 and 2.37?mg/kg/day (crack and crevice scenario) and 0.73 and 0.36?mg/kg/day (fogger), respectively. The dermal exposure estimates (99th percentile) for the crack and crevice scenario were 16.52, 12.82, 3.57, and 3.30?mg/kg/day for CARES, Calendex, SHEDS, and ConsExpo, respectively. Dermal exposure estimates for the fogger scenario from CARES and Calendex (1.50 and 1.47?mg/kg/day, respectively) were slightly higher than those from SHEDS and ConsExpo (0.74 and 0.55?mg/kg/day, respectively). The ConsExpo derived non-dietary ingestion estimates (99th percentile) under these two scenarios were higher than those from SHEDS, CARES, and Calendex. All models produced extremely low exposure estimates for the flying insect killer scenario. Using similar data inputs, the model estimates by route for these scenarios were consistent and comparable. Most of the models predicted exposures within a factor of 5 at the 50th and 99th percentiles. The differences identified are explained by activity assumptions, input distributions, and exposure algorithms. PMID:22781436

Young, Bruce M; Tulve, Nicolle S; Egeghy, Peter P; Driver, Jeffrey H; Zartarian, Valerie G; Johnston, Jason E; Delmaar, Christiaan J E; Evans, Jeffrey J; Smith, Luther A; Glen, Graham; Lunchick, Curt; Ross, John H; Xue, Jianping; Barnekow, David E



The politics of energy: Case study of Con Edison's nuclear complex at Indian Point, New York. Working paper  

Microsoft Academic Search

The possible impact of areawide residential location policy on future residential electricity usage in the Tri-State Metropolitan Region centering on New York City is investigated. This paper focuses on the politics of energy in its discussion of Con Edison's Nuclear Complex at Indian Point. The first period of planning (1954 to the late 60's) comprised a relatively closed decision-making process

J. Aron; K. Seelman



Evaluating the decisional balance construct of the Transtheoretical Model: are two dimensions of pros and cons really enough?  

Microsoft Academic Search

Objectives  The Transtheoretical Model of behavior change (TTM) postulates that behavior change is a process involving progress through\\u000a five distinct stages of change (SOC). One of the key components for progress to a later stage is decisional balance (pros\\u000a and cons of changing to the target behavior). The goal of the present study is to test the two dimensions of decisional

Chantal Kroll; Roger Keller; Urte Scholz; Sonja Perren



Mitochondria-Dependent Apoptosis of Con A-Activated T Lymphocytes Induced by Asiatic Acid for Preventing Murine Fulminant Hepatitis  

PubMed Central

Selectively facilitating apoptosis of activated T cells is essential for the clearance of pathogenic injurious cells and subsequent efficient resolution of inflammation. However, few chemicals have been reported to trigger apoptosis of activated T cells for the treatment of hepatitis without affecting quiescent T cells. In the present study, we found that asiatic acid, a natural triterpenoid, selectively triggered apoptosis of concanavalin A (Con A)-activated T cells in a mitochondria-dependent manner indicated by the disruption of the mitochondrial transmembrane potential, release of cytochrome c from mitochondria to cytosol, caspases activation, and cleavage of PARP. In addition, asiatic acid also induced the cleavage of caspase 8 and Bid and augmented Fas expression in Con A-activated T cells. However, following activation of T cells from MRLlpr/lpr mice with mutation of Fas demonstrated a similar susceptibility to asiatic acid-induced apoptosis compared with normal T cells, suggesting that Fas-mediated death-receptor apoptotic pathway does not mainly contribute to asiatic acid-induced cell death. Furthermore, asiatic acid significantly alleviated Con A-induced T cell-dependent fulminant hepatitis in mice, as assessed by reduced serum transaminases, pro-inflammatory cytokines, and pathologic parameters. Consistent with the in vitro results, asiatic acid also induced apoptosis of activated CD4+ T cells in vivo. Taken together, our results demonstrated that the ability of asiatic acid to induce apoptosis of activated T cells and its potential use in the treatment of T-cell-mediated inflammatory diseases.

Guo, Wenjie; Liu, Wen; Hong, Shaocheng; Liu, Hailiang; Qian, Cheng; Shen, Yan; Wu, Xuefeng; Sun, Yang; Xu, Qiang



Anti-human IG and B lymphocytes reconstitute the proliferative response to Con A of T lymphocytes depleted of accessory cells  

SciTech Connect

The requirements for the induction of proliferation of human peripheral blood mononuclear cells (PBM) by low concentrations of Concanavalin A (Con A) were studied using /sup 3/H-thymidine incorporation to assay DNA synthesis. Removal of plastic-adherent cells from PBM reduced the proliferative response of lymphocytes to Con A by 80%. Passage of these cells over nylon wool columns totally eliminated their response to Con A. Addition of adherent monocytes or rabbit anti-human IgG conjugated to polyacrylamide beads (anti-IgG beads) to the non-adherent lymphocyte population reconstituted the proliferative response. The lymphoblasts activated in these cultures were more than 90% T11 positive. Anti-IgG beads did not activate lymphocyte proliferation in the absence of Con A. The response of non-adherent lymphocytes to Con A could also be reconstituted by unconjugated rabbit anti-human IgG antiserium. Purified T cells could only be activated by anti-IgG beads and low concentrations of Con A in the presence of irradiated B cells. These results suggest that /sup 3/H-thymidine incorporation by T cells induced by anti-IgG beads and a low concentration of Con A depends on the interaction of anti-IgG and B cells. The authors suggest that B cell produce growth factors for T cells after interacting with anti-IgG.

Tsuda, T.; Kim, Y.T.; Schwab, R.; Siskind, G.W.; Weksler, M.E.



Calcium balance in haemodialysis--do not lower the dialysate calcium concentration too much (con part).  


The debate on the most adequate dialysate calcium concentration for intermittent haemodialysis therapy is ongoing. There is probably no one optimal concentration. In general, one would like to maintain a neutral calcium balance in adult haemodialysis patients. However, a slightly negative balance may be preferable to avoid soft-tissue calcium accumulation in face of net calcium loss from the bone with ageing. The problem with measurements of calcium balance is that they are generally imprecise, as are estimations of total body calcium and its distribution in various compartments, unless done with labour-intensive methods and great care. The choice of the dialysate calcium will depend on several factors, including parathyroid and vitamin D status, type and severity of concomitant bone disease, presence or absence of arterial calcification, dietary habits, drug treatment and dialysis modality. Ideally the dialysate calcium would be adapted to each patient's needs. This is not feasible, however, in most dialysis settings and neither is it cost-effective. From a practical point of view, a relatively high dialysate calcium concentration in the range of of 1.50-1.75 mmol/L (3.0-3.5 mEq/L) should probably be preferred in haemodialysis patients with high serum PTH levels who are not prescribed calcium-based phosphate binders or high doses of active vitamin D sterols, and in those who are receiving a calcimimetic. In those who are treated with high doses of calcium-based binders and/or active vitamin D derivatives or who have a very low serum PTH level, the optimal dialysate calcium concentration is probably lower, in the range of 1.25-1.50 mmol/L (2.50-3.0 mEq/L). In the present pro/con debate about the optimal dialysate calcium concentration used for the haemodialysis session, we have accepted to defend the viewpoint that a low calcium concentration may do more harm than benefit in many patients. This viewpoint is opposite to that taken by Gotch. He argues that since calcitriol and other active vitamin D derivatives have become available virtually all haemodialysis patients are in positive calcium balance. We would like to take issue with this statement and warn against the indiscriminate use of a low calcium dialysate in all patients receiving haemodialysis therapy. PMID:19666667

Drüeke, Tilman B; Touam, Malik



Use of colloidal gold and ruthenium red in stereo high-voltage electron microscopic study of Con A-binding sites in mouse macrophages  

Microsoft Academic Search

Concanavalin A (Con A)-binding sites were labeled with colloidal gold (CG), stained with ruthenium red, and observed under a high-voltage electron microscope. Mouse peritoneal macrophages were labeled by the indirect Con A\\/CG labeling method at 0° C. After washing, some of the cells were incubated in phosphate-buffered saline (PBS) at 37° C. The specimens were then stained with ruthenium red,

K. Takata; T. Arii; S. Yamagishi; H. Hirano



Lectin from Canavalia brasiliensis seeds (ConBr) is a valuable biotechnological tool to stimulate the growth of Rhizobium tropici in vitro.  


To study the interactions between a Rhizobium tropici strain and lectins isolated from the seeds of Canavalia ensiformis (ConA) and Canavalia brasiliensis (ConBr), a lectin fluorescence assay was performed. In addition, an experiment was designed to evaluate the effect of the two lectins on bacterial growth. Both lectins were found to bind to R. tropici cells, but the interactions were inhibited by D-mannose. Interestingly, only ConBr stimulated bacterial growth in proportion to the concentrations used (15.6-500 ?g/mL), and the bacterial growth stimulation was inhibited by D-mannose as well. Structure/Function analyses by bioinformatics were carried out to evaluate the volume and carbohydrate recognition domain (CRD) configuration of ConA and ConBr. The difference of spatial arrangement and volume of CRD may indicate the variation between biological activities of both lectins. The results suggest that ConBr could be a promising tool for studies focusing on the interactions between rhizobia and host plants. PMID:22565477

de Vasconcelos, Mayron Alves; Cunha, Claudio Oliveira; Arruda, Francisco Vassiliepe Sousa; Carneiro, Victor Alves; Mercante, Fabio Martins; do Nascimento Neto, Luiz Gonzaga; de Sousa, Giselly Soares; Rocha, Bruno Anderson Matias; Teixeira, Edson Holanda; Cavada, Benildo Sousa; dos Santos, Ricardo Pires



CONS-COCOMAPS: a novel tool to measure and visualize the conservation of inter-residue contacts in multiple docking solutions  

PubMed Central

Background The development of accurate protein-protein docking programs is making this kind of simulations an effective tool to predict the 3D structure and the surface of interaction between the molecular partners in macromolecular complexes. However, correctly scoring multiple docking solutions is still an open problem. As a consequence, the accurate and tedious screening of many docking models is usually required in the analysis step. Methods All the programs under CONS-COCOMAPS have been written in python, taking advantage of python libraries such as SciPy and Matplotlib. CONS-COCOMAPS is freely available as a web tool at the URL: Results Here we presented CONS-COCOMAPS, a novel tool to easily measure and visualize the consensus in multiple docking solutions. CONS-COCOMAPS uses the conservation of inter-residue contacts as an estimate of the similarity between different docking solutions. To visualize the conservation, CONS-COCOMAPS uses intermolecular contact maps. Conclusions The application of CONS-COCOMAPS to test-cases taken from recent CAPRI rounds has shown that it is very efficient in highlighting even a very weak consensus that often is biologically meaningful.



[Clinico-anatomic correlations of aphasia syndromes in the acute state of brain insult].  


The data from an analysis of 104 patients who died in the acute stage of apoplexy are reported. A clinical anatomic and neuropsychological analysis as well as comparison with the foci of the lesions was made. The data confirmed once more the results of many authors--from Broco to recent days and showed that these areas formed the "nucleus" of the cerebral mechanism of the speech. Inspite of the fact that the speech as a function could not be localized in one area of the Central Nervous System, the so called "speech areas" of the dominant hemisphere play an important role in the functioning of the speech system--its "cerebral mechanisms" are set there. PMID:6207553

Raychev, R; Ovcharova, P; Sirakov, P



[Primary Ewing's sarcoma of the mandible. A clinico-pathological and immunohistochemical case study].  


A rare case of Ewing's sarcoma, originating in the mandible, is reported. The symptomatologic and radiological aspects is often aspecific. For this reason the diagnostic-therapeutic routine is presented and the difficulty of clinical diagnosis is accentuated. In these cases it may be appropriate to make use of immunohistochemical analysis such as the research of markers like the NSE (Neuro-Specific Enolase). This will be useful to reach an accurate preoperative diagnosis and in order to adopt a correct therapeutic protocol. PMID:9221322

Zavaglia, V; Nori, A; Campanati, G; Goteri, G



Calpain 3 gene mutations: genetic and clinico-pathologic findings in limb-girdle muscular dystrophy  

Microsoft Academic Search

Mutations in the calpain 3 gene have been proven to be responsible for limb-girdle muscular dystrophy (LGMD) type 2A. To determine the incidence and genotypes of the calpain 3 (p94) gene mutations in Japanese LGMD patients, we sequenced the gene in 80 patients with clinical characteristics of autosomal recessive or sporadic LGMD. We identified 13 distinct pathogenic mutations in 21

Jonghee Chae; Narihiro Minami; Yuko Jin; Masahiro Nakagawa; Kumiko Murayama; Fumie Igarashi; Ikuya Nonaka



C-reactive Protein and Malignancy: Clinico-pathological Association and Therapeutic Implication  

Microsoft Academic Search

C-reactive protein (CRP) is a widely used systemic bio- marker for diagnosing acute and chronic inflammation. During the past decade, serum CRP has been re-emphasized by extend- ing its clinical use to the prediction or diagnosis of cardiovascu- lar diseases and other conditions, particularly malignancies. Serum CRP has also been found to be elevated in patients with many malignancies, implying

Chia-Siu Wang; Chien-Feng Sun


Clinico-Microbiological Aspects of Necrotising Fasciitis in Type II Diabetes Mellitus  

Microsoft Academic Search

Necrotising fasciitis is insidiously advancing soft tissue infection, characterized by widespread fascial necrosis. One of\\u000a the most common conditions encountered in the clinical practice and which required clinical suspicion in patients who have\\u000a less resistance to these infections. Especially in diabetic patients who are more prone for such infection due to low immunity\\u000a and other reasons like early detection of

Asayas Bosco Chandra Kumar; S. G. Subramanyam; Arun B. Kilpadi



Ponto-cerebellar hypoplasia with dystonia: clinico-pathological findings in a sporadic case  

Microsoft Academic Search

Microcephaly, absent psychomotor development and dystonic limb movements were the main clinical features of a 3-year-old\\u000a girl affected by hypoplasia of the ponto-cerebellar structures. As in the few previously reported cases there are discrepancies\\u000a between the severity of lesions in the supratentorial and infratentorial compartments. Pathological features such as size\\u000a reduction of the ventral pons, inferior olive atrophy, dentate nucleus

Alessandro Simonati; Bernardo Dalla Bernardina; Romano Colombari; Nicoló Rizzuto



[Clinico-pharmacological investigation of drugs (domperidone, bromocriptine) influencing human prolactin levels from pregnancy to menopause].  


The influence of Motilium (domperidone) tablet on the increase of human prolactin level was investigated in the first and second trimester of pregnancy, in confinement and menopause. It has been stated that domperidone causes the serum prolactin level to increase not only in pregnancy and confinement but in menopause, too, not depending on whether it was spontaneous or it took place after castration. In spite of the fact that domperidone is a dopamine antagonist it increases the FSH level similarly to bromocriptine which is a dopamine agonist, although the serum prolactin level changes in the opposite direction on the effect of the treatment. The decrease of the prolactin level effected by bromocriptine tablet in physiological and pathological galactorrhoea and in hyperprolactinaemia associated with infertility has also been investigated. In addition to the favourable laboratory and clinical results it has been stated that prolactin regulates the changes of the FSH and LH levels both in fertility and menopause. PMID:8116455

Farkas, M



[Muscle spasms in patients with amyotrophic lateral sclerosis (clinico-electromyographnic analysis)].  


The diagnostic importance and electromyographic characteristics of the muscular spasms were studied in patients with lateral amyotrophic sclerosis at various stages of the disease. It has been shown that the muscular spasms are a typical symptom of this disease, and may be an early manifestation of the latter. The clinical and electromyographic characteristics of the spasms depend on the depth of the pathological process. Of importance in the origin of the muscular spasms in the lateral amyotrophic sclerosis is involvement of many levels of the cortico-muscular path, however, distrubances of the intraspinal mechanisms are, probably, the leading cause. PMID:465160

Khondkarian, O A; Zavalishin, I A; Novikova, V P



[Alcoholism survey. Clinico-statistical study of 3009 patients in a General Medicine Division].  


The alarming spread of alcoholism is noted and its aetiology is examined in the light of its many causes and influencing factors. Steps to stem the tide are discussed, along with the methods to be adopted and the persons by whom they should be put into effect. Drinkers are classed as large and small alcoholics and the incidene of alcoholism in 3009 male and female patients is examined in the light of the type of drink involved, occupation, age and reason for admission to hospital. Attention is drawn to the high number of male alcoholics. Screening for alcoholism in hospital is recommended as a means of preventing the syndrome. PMID:687075

Grosso, F


[Clinico-roentgenological diagnosis of the perifocal inflammatory process in patients with cancer of the rectum].  


An examination of 1525 patients has established that the main clinical symptoms of the perifocal inflammatory process are: hyperthermia of different degrees, leukocytosis and higher ESR, pain in the rectum area and in the abdomen, tenderness and pasty tissues in the tumor area. The roentgenological symptoms are: the presence of fistulas, considerable dilatation of presacral space not corresponding to the tumor size, pathological "cellularity" of the paraintestinal tissues. PMID:3452258

Odariuk, T S; Arablinski?, V M; Amelin, V M; Mushnikova, V N; Tikhonov, A A



Hereditary spastic paraplegia: clinico-pathologic features and emerging molecular mechanisms.  


Hereditary spastic paraplegia (HSP) is a syndrome designation describing inherited disorders in which lower extremity weakness and spasticity are the predominant symptoms. There are more than 50 genetic types of HSP. HSP affects individuals of diverse ethnic groups with prevalence estimates ranging from 1.2 to 9.6 per 100,000. Symptoms may begin at any age. Gait impairment that begins after childhood usually worsens very slowly over many years. Gait impairment that begins in infancy and early childhood may not worsen significantly. Postmortem studies consistently identify degeneration of corticospinal tract axons (maximal in the thoracic spinal cord) and degeneration of fasciculus gracilis fibers (maximal in the cervico-medullary region). HSP syndromes thus appear to involve motor-sensory axon degeneration affecting predominantly (but not exclusively) the distal ends of long central nervous system (CNS) axons. In general, proteins encoded by HSP genes have diverse functions including (1) axon transport (e.g. SPG30/KIF1A, SPG10/KIF5A and possibly SPG4/Spastin); (2) endoplasmic reticulum morphology (e.g. SPG3A/Atlastin, SPG4/Spastin, SPG12/reticulon 2, and SPG31/REEP1, all of which interact); (3) mitochondrial function (e.g. SPG13/chaperonin 60/heat-shock protein 60, SPG7/paraplegin; and mitochondrial ATP6); (4) myelin formation (e.g. SPG2/Proteolipid protein and SPG42/Connexin 47); (5) protein folding and ER-stress response (SPG6/NIPA1, SPG8/K1AA0196 (Strumpellin), SGP17/BSCL2 (Seipin), "mutilating sensory neuropathy with spastic paraplegia" owing to CcT5 mutation and presumably SPG18/ERLIN2); (6) corticospinal tract and other neurodevelopment (e.g. SPG1/L1 cell adhesion molecule and SPG22/thyroid transporter MCT8); (7) fatty acid and phospholipid metabolism (e.g. SPG28/DDHD1, SPG35/FA2H, SPG39/NTE, SPG54/DDHD2, and SPG56/CYP2U1); and (8) endosome membrane trafficking and vesicle formation (e.g. SPG47/AP4B1, SPG48/KIAA0415, SPG50/AP4M1, SPG51/AP4E, SPG52/AP4S1, and VSPG53/VPS37A). The availability of animal models (including bovine, murine, zebrafish, Drosophila, and C. elegans) for many types of HSP permits exploration of disease mechanisms and potential treatments. This review highlights emerging concepts of this large group of clinically similar disorders. PMID:23897027

Fink, John K



[Clinico-quatitative evaluation of the action of Ciba 34.647-Ba on spasticity].  


Using the clinical quantification of the neurologic symptomatology the authors made observations and avaliated the action of Ciba 34.647-Ba, a GABA derivative, in 12 patients suffering from spasticity and motor incapacity due to spinal cord lesions. The results are reported emphasizing the effects of the drug on the main components of spasticity (hypertonus, hyperactivity of the deep reflexes, clonus and automatisms). Some theories explaining the mechanism of action of the drug are mentioned. References are made about doses, duration of action, tolerance and side-effects. PMID:588090

Roitman, I; Anghinah, A



A functioning black adenoma of the adrenal cortex: A clinico-pathological entity  

PubMed Central

A 25-year-old woman is described who had suspected hyperfunction of the adrenal cortex. She complained of fatiguability, excessive hair growth, and attacks of swelling of the face, hands, and ankles. Moreover she had a `moon face', hypertension, a `buffalo hump', and livid striae of the loins and hypogastrium. Adrenal function tests yielded values which could not be clearly interpreted. Operation showed a `black adenoma' of the adrenal cortex on the right side. As far as it is known this is the first published case of this extremely rare lesion which was operated upon and caused nearly complete remission of the endocrine disturbance. Images

Visser, J. W.; Boeijinga, J. K.; Meer, C. V. D.



Meesmann Corneal Dystrophy; a Clinico-Pathologic, Ultrastructural and Confocal Scan Report  

PubMed Central

Purpose To report the microstructural features of Meesmann corneal dystrophy (MCD) in two patients. Case Report The first patient was a 10-year-old boy who presented with bilateral visual loss, diffuse corneal epithelial microcystic changes, high myopia and amblyopia. With a clinical impression of MCD, automated lamellar therapeutic keratoplasty was performed in his left eye. Histopathologic examination of the corneal button disclosed epithelial cell swelling and cyst-like intracytoplasmic inclusions. The cells contained moderate amounts of periodic acid-Schiff-positive and diastase-sensitive material (glycogen). Transmission electron microscopy revealed numerous vacuoles and moderate numbers of electron-dense membrane-bound bodies in the cytoplasm, similar to lysosomes, some engulfed by the vacuoles. The second patient was a 17-year-old female with a clinical diagnosis of MCD and episodes of recurrent corneal erosion. On confocal scan examination of both corneas, hyporeflective round-shaped areas measuring 6.8 to 41.4 ?m were seen within the superficial epithelium together with irregular and ill-defined high-contrast areas in the sub-basal epithelial region. The subepithelial nervous plexus was not visible due to regional hyperreflectivity. Conclusion This case report further adds to the microstructural features of Meesmann corneal dystrophy and suggests confocal scan as a non-invasive method for delineating the microstructural appearance of this rare dystrophy.

Javadi, Mohammad-Ali; Rezaei-Kanavi, Mozhgan; Javadi, Atefeh; Naghshgar, Nima



[These vocal cords lesions termed sulcus glottidis: clinico-anatomical considerations].  


Among the difficult cases which phonosurgeons may encounter, the problem of vergetures is one of the most complex. The primum movens would seem to be a particular vocal fold lesion in the form of more or less pronounced ligament atrophy. About a retrospective study of 52 cases, the authors present their conclusions: This atrophy co-exists anatomically, with (a sometimes considerable amount of atrophied mucosa opposite, "glottal tension" clearly perceptible during surgery, especially along the lower edge); videostroboscopically, with (great vibratory rigidity, more or less severe glottal air-loss). This lesion is completely distinct from a sulcus (the surgical treatment wil be discussed in an other paper). PMID:16676551

Pérouse, R; Coulombeau, B



[Biochemical and clinico-pharmacological aspects of antimetabolites in the treatment of leukemia].  


Methotrexate (MTX) and 6-mercaptopurine (6MP) have been used since 30 years in the maintenance treatment of acute lymphoblastic leukemia (ALL) of childhood. A synergistic effect of this combination was demonstrated in mouse and childhood leukemia. In this article an overview is given of our investigations, concerning the biochemical basis of this synergism. This synergism is caused by a selective inhibition of the purine de novo synthesis in malignant lymphoblasts by MTX, associated with an enhanced intracellular uptake of 6MP. Pharmacokinetic studies of MTX in various schemes of prophylactic central nervous system treatment in ALL are discussed. Treatment with 24-hr infusions of MTX in a dosage of 5 g/m2, as recommended in the new BFM-86/SNWLK ALL VII protocol, seems to be optimal. Pharmacokinetic studies of intravenous 6MP infusions demonstrated a good cerebral fluid penetration. Exploiting the synergistic action of the combination of MTX and 6MP may offer an improvement of the prophylactic central nervous systems treatment in ALL in the future, using intravenous administration of both MTX and 6MP. PMID:3287684

Bökkerink, J P; de Abreu, R A; Lippens, R J; Schouten, T J; de Vaan, G A



Extending Workflow Management for Knowledge Discovery in Clinico-Genomic Data  

Microsoft Academic Search

Recent advances in research methods and technologies have resulted in an explosion of information and knowledge about cancers and their treatment. Knowledge Discovery (KD) is a key technique for dealing with this massive amount of data and the challenges of managing the steadily growing amount of available knowledge. In this paper, we present the ACGT integrated project, which is to



[Clinico-virologic analysis of the incidence of tick-borne encephalitis in the Khabarovskh region].  


In the Soviet Union the incidence of tick-borne encephalitis is the highest in the geographical and epidemiological region adjacent to the Amur River (zone of coniferous and broad-leaved forests). 60.43% of all cases fall on years of cyclic rise of the disease incidence. Strains of the tick-borne encephalitis virus can be isolated with a more significant frequency from the blood of encephalitis-sick patients and from the brain of the dead in the years of disease outbreaks. PMID:7234258

Vereta, L A; Aleksandrov, V I; Nikolaeva, S P; Vladimirova, T P; Kazantseva, S I



Clinico-pathological features and management of lung cancer patients with atherosclerotic vascular diseases.  


Purpose: Increased numbers of patients with both lung cancer and atherosclerotic vascular disease (AVD) may be expected in the future. The aim of this study was to report the incidence of lung cancer in patients with AVD and to discuss patient characteristics and management.Method: A total of 638 patients who underwent AVD treatment were investigated.Results: Lung cancer was observed in 17 (2.7%) of 638 patients studied. The proportion of smoking history was significantly higher in patients with lung cancer (p = 0.0091).The pack-year index in patients with lung cancer was significantly higher than that in patients without lung cancer (p = 0.0073). Although 4 of 6 (66.7%) patients with concomitant lung cancer and AVD had stage I or II lung cancer, 5 of 7 (71.4%) patients with lung cancer diagnosed after AVD treatment had stage III or IV lung cancer. In patients with lung cancer found after AVD treatment, only 1 of 7 patients underwent surgical resections. The time until lung cancer was 12 to 198 months with a mean of62.5 months after AVD treatment. In concomitant cases, priority was given to AVD treatment in all 5 cases, and there were no serious events after the postoperative course.Conclusions: Both patients with a smoking history and heavy smokers were at high risk for lung cancer, and most lung cancers found after AVD treatment were in the advanced stages and had poor prognoses. Therefore, we recommend careful and routine follow-up for screening lung cancer after AVD treatment. PMID:23237931

Shoji, Fumihiro; Morodomi, Yosuke; Kyuragi, Ryoichi; Okamoto, Tatsuro; Matsumoto, Takuya; Yano, Tokujiro; Maehara, Yoshihiko



Becker's variant of myotonia congenita in two siblings--a clinico-genetic study.  


We report a family of a brother and sister of myotonia congenita, conforming to autosomal recessive transmission (Becker's variety). To the best of our knowledge, no account of a family of autosomal recessive myotonia (Becker's disease), has earlier been reported from India. PMID:15472428

Bhattacharyya, Kalyan B; Sengupta, P; Basu, S; Bhattacharya, N P



[Significance of polyglucosan bodies in neuropathology. Clinico-pathologic study of seven cases].  


Seven observations, having in common an accumulation of polyglucosan bodies in the nervous system, are reported. In 2 cases of adult polyglucosan body disease, characteristic polyglucosan bodies were found on the peripheral nerve biopsies, and also on the cerebral biopsy in one of these patients who was demented. The 5 other cases presented medically intractable temporal lobe epilepsy. Recovery was obtained by a temporal lobectomy in which a massive accumulation of polyglucosan bodies was discovered. These personal observations are discussed with regard to other conditions characterized by accumulation of polyglucosan bodies in the nervous system. The non specificity of these formations is emphasized. PMID:8519394

Vital, A; Lamarche, J; Bernier, J P; Boulan-Predseil, P; Loiseau, H; Rougier, A; Henry, P; Vital, C



Clinico-microbiological study of opportunistic infection in HIV seropositive patients  

PubMed Central

Objectives: The present study was undertaken to determine the prevalence of respiratory, gastrointestinal and other pathogens in 100 Human Immunodeficiency Virus (HIV) seropositive patients. Settings: This study was carried out on randomly selected 100 HIV seropositive patients from S. S. G. Hospital during the period from Jan 2006 to Jan 2007. Materials and Methods: Sputum samples, stool samples and oral swabs were collected from all the patients and cerebrospinal fluid (CSF) was collected from symptomatic patients and processed as per the standard protocol. Sputum samples were examined by microscopy and cultured for bacterial respiratory pathogens. Stool samples were concentrated and examined by microscopy for enteric parasites. Oral swabs and CSF were also examined microscopically and cultured for fungal pathogens. CSF was also examined for bacterial pathogens. Results: A total of 101 pathogens were detected in 60 patients. More than one pathogen was observed in 30 patients. Candida was the commonest isolate (32.67%), followed by Mycobacterium tuberculosis (22.71%) and Cryptosporidium parvum (19.8%). Conclusions: Since opportunistic infections are a major cause of mortality and morbidity in HIV seropositive patients, an early diagnosis and effective treatment are required to tackle them. The type of pathogens infecting HIV patients varies from region to region, and therefore such patients should be constantly screened for these pathogens.

Patel, Sangeeta D.; Kinariwala, Dipa M.; Javadekar, Tanuja B.



[Clinico-diagnostic and expert characteristics of noncoronary cardiac rhythm disorders in state aviation pilots].  


Structure and prevalence of various forms of noncoronary heart diseases (NCHD) and cardiac rhythm disorders (CRD) in state aviation pilots, as well as rates of ensuing grounding were studied. The total of 220 NCHD and 100 essentially healthy pilots were examined. Cardiovascular clinical and functional investigations consisted of physical examination, ECG, dispersion mapping (DM ECG), provocative tests and other techniques used for pilots' certification. Effectiveness of the clinical and instrumental methods of diagnosing arrhythmias was evaluated. CRD presence was verified by Holter monitoring. Extrasystoles prevalence was recorded in NCHD pilots; clinically significant forms of the diseases were commonly detected in pilots with chronic infections of the tonsils. In addition, radiodiagnostics of the immune status was applied to confirm the role of infection and immunology factor. DM ECG screening for differentiation between the norm and pathology was found useful in detecting early metabolic shifts and CVS functional evaluation. These results provided the basis for guidelines concerning medical expertise of pilots with noncoronary arrhythmias. PMID:24032165


Clinico-pathological and treatment-related factors influencing survival in parotid cancer  

Microsoft Academic Search

One hundred and three patients with primary parotid cancer treated surgically at the Christie Hospital, Manchester (1952–1992), were analysed to assess the influence on survival of prognostic and treatment-related factors. Thirty-seven patients were treated by surgery alone (SG), 66 received post-operative radiation (SG+RT). Median follow-up was 12 years, minimum 5 years. The 10-year disease-specific survival rates for stage I, II

A G Renehan; E N Gleave; N J Slevin; M McGurk



Clinico-radiologic characteristics of long-term survivors of diffuse intrinsic pontine glioma.  


Diffuse intrinsic pontine glioma (DIPG) is the deadliest central nervous system tumor in children. The survival of affected children has remained poor despite treatment with radiation therapy (RT) with or without chemotherapy. We reviewed the medical records of all surviving patients with DIPG treated at our institution between October 1, 1992 and May 31, 2011. Blinded central radiologic review of the magnetic resonance imaging at diagnosis of all surviving patients and 15 controls with DIPG was performed. All surviving patients underwent neurocognitive assessment during follow-up. Five (2.6 %) of 191 patients treated during the study period were surviving at a median of 9.3 years from their diagnosis (range 5.3-13.2 years). Two patients were younger than 3 years, one lacked signs of pontine cranial nerve involvement, and three had longer duration of symptoms at diagnosis. One patient had a radiologically atypical tumor and one had a tumor originating in the medulla. All five patients received RT. Chemotherapy was variable among these patients. Neurocognitive assessments were obtained after a median interval of 7.1 years. Three of four patients who underwent a detailed evaluation showed cognitive function in the borderline or mental retardation range. Two patients experienced disease progression at 8.8 and 13 years after diagnosis. A minority of children with DIPG experienced long-term survival with currently available therapies. These patients remained at high risk for tumor progression even after long follow-ups. Four of our long-term survivors had clinical and radiologic characteristics at diagnosis associated with improved outcome. PMID:23813229

Jackson, Sadhana; Patay, Zoltan; Howarth, Robyn; Pai Panandiker, Atmaram S; Onar-Thomas, Arzu; Gajjar, Amar; Broniscer, Alberto



Inherited metabolic disorders involving the eye: a clinico-biochemical perspective.  


The diagnosis of inborn errors of metabolism is challenging for most physicians. Improvements in medical technology and greater knowledge of the human genome are resulting in significant changes in the diagnosis, classification, and treatment of inherited metabolic disorders (IMDs). Many known inborn errors of metabolism will be recognised earlier or treated differently because of these changes. It is important that physicians recognise the clinical signs of IMDs and know when to propose advanced laboratory testing or referral to a higher centre for better patient management. Ocular manifestations occur in various metabolic disorders. Although there is an extensive understanding of many inborn errors of metabolism at the biochemical, molecular, and metabolic levels, little is known about their pathogenesis. In particular, how systemic metabolic disease contributes to ocular defects remains to be elucidated in IMDs. The occurrence of eye abnormalities could be due to direct toxic mechanisms of abnormal metabolic products or accumulation of normal metabolites by errors of synthetic pathways or by deficient energy metabolism. A detailed ophthalmological assessment is essential. Definitive diagnosis and management of patients with IMDs is ideally carried out by a combination of specialists, including an ophthalmologist, paediatrician, biochemist, and medical geneticist. Recent advances in the diagnosis and treatment of IMDs have substantially improved the prognosis for many of these conditions. PMID:19798114

Rajappa, M; Goyal, A; Kaur, J



Clinico-immunological response to intratumoral versus intravenous neoadjuvant chemotherapy in advanced pediatric solid malignancies  

PubMed Central

Background: There is minimal literature on the use of intralesional chemotherapy in the pediatric age group. We undertook this present study to evaluate the two modalities (intratumoral and intravenous) of giving chemotherapy in terms of toxicity of chemotherapy, hematological parameters, efficacy of chemotherapy in reduction in volume of the tumor as well as resectability of tumor with special emphasis on immunological parameters. Materials and Methods: Advanced cases of Wilms’ tumor and Neuroblastoma were included in the study. Intratumoral chemotherapy was given through 25 G spinal needle under aseptic precautions and ultrasound guidance in the same dose as in systemic chemotherapy. Intravenous group was given chemotherapy in the usual way. Reassessment was carried out after every course of chemotherapy. Results: Group A included 16 cases of Wilms’ tumor and 6 cases of neuroblastoma. In group B, there were 14 cases of Wilms’ tumor and 8 of neuroblastoma. Vomiting, diarrhea, mucositis, and thrombophlebitis were more common in the intravenous group (P<0.05). The fall in Immunoglobulin A, Immunogloblulin G, Immunoglobulin M, and T-cell rosetting was more common in the intravenous group (P<0.05). Seventy percent of patients had completely resectable tumor at the end of 6 doses of intratumoral chemotherapy as compared to 50% resectability in the intravenous group (P<0.05). Conclusion: Intratumoral chemotherapy, besides causing less of the adverse effects and increasing the resecability rate, also causes less suppression of the immune system. This may be offered as an alternative safe and effective modality of treatment for advanced solid tumors.

Kumar, Vijayendra; Ramaswami, Nandini; Pandey, Anand; Shukla, Ram Chandra; Sen, Maloy Ranjan; Sharma, Shiv Prasad; Gupta, Dinesh Kumar; Gangopadhyay, Ajay Narayan



RET/PTC Translocations and Clinico-Pathological Features in Human Papillary Thyroid Carcinoma  

PubMed Central

Thyroid carcinoma is the most frequent endocrine cancer accounting for 5–10% of thyroid nodules. Papillary histotype (PTC) is the most prevalent form accounting for 80% of all thyroid carcinoma. Although much is known about its epidemiology, pathogenesis, clinical, and biological behavior, the only documented risk factor for PTC is the ionizing radiation exposure. Rearrangements of the Rearranged during Transfection (RET) proto-oncogene are found in PTC and have been shown to play a pathogenic role. The first RET rearrangement, named RET/PTC, was discovered in 1987. This rearrangement constitutively activates the transcription of the RET tyrosine-kinase domain in follicular cell, thus triggering the signaling along the MAPK pathway and an uncontrolled proliferation. Up to now, 13 different types of RET/PTC rearrangements have been reported but the two most common are RET/PTC1 and RET/PTC3. Ionizing radiations are responsible for the generation of RET/PTC rearrangements, as supported by in vitro studies and by the evidence that RET/PTC, and particularly RET/PTC3, are highly prevalent in radiation induced PTC. However, many thyroid tumors without any history of radiation exposure harbor similar RET rearrangements. The overall prevalence of RET/PTC rearrangements varies from 20 to 70% of PTCs and they are more frequent in childhood than in adulthood thyroid cancer. Controversial data have been reported on the relationship between RET/PTC rearrangements and the PTC prognosis. RET/PTC3 is usually associated with a more aggressive phenotype and in particular with a greater tumor size, the solid variant, and a more advanced stage at diagnosis which are all poor prognostic factors. In contrast, RET/PTC1 rearrangement does not correlate with any clinical–pathological characteristics of PTC. Moreover, the RET protein and mRNA expression level did not show any correlation with the outcome of patients with PTC and no correlation between RET/PTC rearrangements and the expression level of the thyroid differentiation genes was observed. Recently, a diagnostic role of RET/PTC rearrangements has been proposed. It can be searched for in the mRNA extracted from cytological sample especially in case with indeterminate cytology. However, both the fact that it can be present in a not negligible percentage of benign cases and the technical challenge in extracting mRNA from cytological material makes this procedure not applicable at routine level, at least for the moment.

Romei, Cristina; Elisei, Rossella



Non-accidental fatal head injury in small children--a clinico-pathological correlation.  


Non-accidental head injury leading to massive intracranial trauma has been identified as a leading cause of death in small children. In a typical case, a child usually below the age of one year is violently shaken, leading to rupture of the connecting veins between the dura mater and the brain substance with variable degrees of bleeding into the subdural space resulting in increased intracranial pressure. The accompanying venous thrombosis affecting the vessels of the brain substance leads to cerebral hypoxia and cellular death. In this study conducted throughout the year 1999, all children below the age of 3 years who were admitted to Hospital Kuala Lumpur and had died due to non-accidental injuries were included. Postmortems, including histopathological studies, were conducted to determine the most likely mechanisms of the injuries. Ten cases were identified for the whole year. In 2 cases, both below one year of age, the features presented showed evidence of violent shaking of the infants. In 6 other cases whose average age was 13 (range 4-24) months, there were evidences of direct trauma and violent shaking. In the last two cases, aged 24 and 33 months respectively, there was only evidence of direct trauma on the heads without being shaken. This study shows that death due to intracranial trauma caused by shaking with or without direct impact is the most frequent cause of mortality in abused children. Death due to direct impact between the head and another object is a less frequent occurrence. PMID:15559164

Nooraudah, A R; Mohd Sham, K; Zahari, N; Fauziah, K



AVM resection after radiation therapy--clinico-morphological features and microsurgical results.  


A subgroup of patients initially treated by radiosurgery underwent surgical resection because of recurrent hemorrhage or neurological deterioration. In a retrospective study, we want to analyze the clinical features of these patients and evaluate the effect of microneurosurgery in such rare constellations. Moreover, we hope to find answers about failure of radiation therapy in these cases by correlation of radiobiological and histopathological data. Over a 16-year-period, eight patients with cerebral arteriovenous malformation (AVM) underwent surgical resection, who previously were treated by radiosurgery. The mean duration between radiation therapy and final resection was 7 years. Preoperative evaluation revealed Spetzler-Martin grade III (n=5) and IV (n=3) AVMs. Histological examination was achieved in all resected lesions. Mean neurological follow-up was 14 months. Indications for surgical resection were intracerebral hematoma, progressive neurological deficit, and epilepsy. In comparison to the initial angiographic study before radiation therapy, preoperative angiography revealed newly developed "en passant" feeding vessels and stenosis of the main venous drainage in some patients. The mean Rankin score for all patients was 2.75 before and 3.25 after surgical resection. Postoperatively, three patients (38%) developed neurological deterioration. Histological examination of the resected tissue revealed significant radiation-induced pathology in six patients. We did not see correlation between radiation doses and severity of histolopathological radiation-induced changes. Postoperative angiography confirmed total AVM resection in all patients. AVMs insufficiently treated by radiation bear an increased surgical risk. Often, angiographic studies revealed a more complicated morphology. Microsurgical resection was extremely challenging and led to unfavorable outcomes in many of the patients. PMID:19669814

Asgari, Siamak; Bassiouni, Hischam; Gizewski, Elke; van de Nes, Johannes A P; Stolke, Dietmar; Sandalcioglu, Ibrahim Erol



Clinico-haematology and pathology of caprine mycoplasmal pneumonia in rain fed tropics of West Bengal  

Microsoft Academic Search

A total of 4500 suspected mycoplasma infected swabs samples were cultivated bacteriologically both in pleuropneumonia like organism (PPLO) broth and agar of which 310 were found positive for mycoplasma infection. Biochemical characterisation and growth inhibition test with known mycoplasmal antisera revealed involvement of three species of mycoplasma namely Mycoplasma agalactiae (Ma, 102), Mycoplasma mycoides subsp. capri (Mmc, 124) and M.

D Mondal; A. K Pramanik; D. K Basak



[New diagnostic methods--ultrasound and clinico-chemical procedures in diagnosis of ischemia].  


Stress-echocardiography represents a new non-invasive, alternative approach in the assessment of patients with coronary artery disease. By means of dynamic or pharmacological stress or by atrial pacing regional wall motion abnormalities can be induced, which can be identified by 2D-echocardiography. Beyond the indirect detection of ischemia this approach allows a better quantification of the amount of ischemia and of global LV function, which is advantageous compared to stress ECG recording or myocardial scintigraphy. Disadvantageous is however, the subjective reading of the echo itself. In experienced hands stress-echocardiography has proven to be as sensitive and specific as myocardial scintigraphy. Recently, in addition the diagnostic potential of myocardial cell injury has been improved by the detection of specific antibodies versus Troponin T. In comparison with conventional biochemical markers of myocardial cell necrosis Troponin T analysis has been proven to be superior in postoperative or traumatic cardiac damage or in the setting of acute myocardial infarction. In this situation the time window is improved by an earlier rise compared to CK and a longer detection rate compared to lactate dehydrogenase. PMID:8154150

Hanrath, P; Hoffmann, R; Lankes, W; Stellbrink, C



Chronic hepatosplenic abscesses in brucellosis. Clinico-therapeutic features and molecular diagnostic approach  

Microsoft Academic Search

In order to analyze the clinical and therapeutic features of chronic hepatosplenic abscesses, and to define the diagnostic yield of new molecular techniques, we describe seven cases, four hepatic and three splenic, of this uncommon complication of Brucellosis. Onset of symptoms in all cases was insidious and the diagnostic delay considerable. Abdominal CT scan showed large, poorly defined lesions, with

Juan de Dios Colmenero; Maria Isabel Queipo-Ortuño; José Maria Reguera; Miguel Angel Suarez-Muñoz; Segundo Mart??n-Carballino; Pilar Morata



Clinico-radiological spectrum of bilateral temporal lobe hyperintensity: a retrospective review.  


Bilateral temporal lobe hyperintensity (BTH) is a commonly encountered MRI finding in a wide spectrum of clinical conditions and often poses a diagnostic challenge to the radiologist. The purpose of this paper is to elucidate several diseases that manifest as BTH on MRI, based on a retrospective review of cranial MRI of 65 cases seen in our institution between October 2007 and September 2010. We found BTH in different clinical scenarios that included infective diseases (herpes simplex virus, congenital cytomegalovirus infection), epileptic syndrome (mesial temporal sclerosis), neurodegenerative disorders (Alzheimer's disease, frontotemporal dementia, Type 1 myotonic dystrophy), neoplastic conditions (gliomatosis cerebri), metabolic disorders (mitochondrial encephalopathy, lactic acidosis and stroke-like episodes, Wilson's disease, hyperammonemia), dysmyelinating disease (megalencephalic leukoencephalopathy with subcortical cysts), and vascular (cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy) and paraneoplastic (limbic encephalitis) disorders. The conventional MRI findings with advanced MRI such as diffusion-weighted imaging, susceptibility-weighted imaging and MR spectroscopy along with laboratory results are potentially helpful in distinguishing the different clinical conditions and thus affect the early diagnosis and clinical outcome. PMID:22422381

Sureka, J; Jakkani, R K



Clinico-radiological spectrum of bilateral temporal lobe hyperintensity: a retrospective review  

PubMed Central

Bilateral temporal lobe hyperintensity (BTH) is a commonly encountered MRI finding in a wide spectrum of clinical conditions and often poses a diagnostic challenge to the radiologist. The purpose of this paper is to elucidate several diseases that manifest as BTH on MRI, based on a retrospective review of cranial MRI of 65 cases seen in our institution between October 2007 and September 2010. We found BTH in different clinical scenarios that included infective diseases (herpes simplex virus, congenital cytomegalovirus infection), epileptic syndrome (mesial temporal sclerosis), neurodegenerative disorders (Alzheimer's disease, frontotemporal dementia, Type 1 myotonic dystrophy), neoplastic conditions (gliomatosis cerebri), metabolic disorders (mitochondrial encephalopathy, lactic acidosis and stroke-like episodes, Wilson's disease, hyperammonemia), dysmyelinating disease (megalencephalic leukoencephalopathy with subcortical cysts), and vascular (cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy) and paraneoplastic (limbic encephalitis) disorders. The conventional MRI findings with advanced MRI such as diffusion-weighted imaging, susceptibility-weighted imaging and MR spectroscopy along with laboratory results are potentially helpful in distinguishing the different clinical conditions and thus affect the early diagnosis and clinical outcome.

Sureka, J; Jakkani, R K



Clinico-Pathologic Function of Cerebral ABC Transporters - Implications for the Pathogenesis of Alzheimer's Disease  

PubMed Central

In recent years it has become evident that ABC transporters fulfill important barrier functions in normal organs and during disease processes. Most importantly, resistance to drugs in cancer cells led to intense oncological and pharmacological investigations in which researchers were able to highlight important pharmacological interactions of chemotherapeuticals with ABC transporter function. Recently, the development of neurodegenerative diseases and the maintenance of neuronal stem cells have been linked to the activity of ABC transporters. Here, we summarize findings from cell culture experiments, animal models and studies of patients with Alzheimer’s disease. Furthermore, we discuss pharmacological interactions and computational methods for risk assessment.

Pahnke, Jens; Wolkenhauer, Olaf; Krohn, Markus; Walker, Lary C.



Clinico-pathological features in amyotrophic lateral sclerosis with expansions in C9ORF72  

PubMed Central

Intronic expansion of the GGGGCC hexanucleotide repeat within the C9ORF72 gene causes frontotemporal dementia and amyotrophic lateral sclerosis/motor neuron disease in both familial and sporadic cases. Initial reports indicate that this variant within the frontotemporal dementia/amyotrophic lateral sclerosis spectrum is associated with transactive response DNA binding protein (TDP-43) proteinopathy. The amyotrophic lateral sclerosis/motor neuron disease phenotype is not yet well characterized. We report the clinical and pathological phenotypes associated with pathogenic C9ORF72 mutations in a cohort of 563 cases from Northern England, including 63 with a family history of amyotrophic lateral sclerosis. One hundred and fifty-eight cases from the cohort (21 familial, 137 sporadic) were post-mortem brain and spinal cord donors. We screened DNA for the C9ORF72 mutation, reviewed clinical case histories and undertook pathological evaluation of brain and spinal cord. Control DNA samples (n?=?361) from the same population were also screened. The C9ORF72 intronic expansion was present in 62 cases [11% of the cohort; 27/63 (43%) familial, 35/500 (7%) cases with sporadic amyotrophic lateral sclerosis/motor neuron disease]. Disease duration was significantly shorter in cases with C9ORF72-related amyotrophic lateral sclerosis (30.5 months) compared with non-C9ORF72 amyotrophic lateral sclerosis/motor neuron disease (36.3 months, P?

Cooper-Knock, Johnathan; Hewitt, Christopher; Highley, J. Robin; Brockington, Alice; Milano, Antonio; Man, Somai; Martindale, Joanne; Hartley, Judith; Walsh, Theresa; Gelsthorpe, Catherine; Baxter, Lynne; Forster, Gillian; Fox, Melanie; Bury, Joanna; Mok, Kin; McDermott, Christopher J.; Traynor, Bryan J.; Kirby, Janine; Wharton, Stephen B.; Ince, Paul G.; Hardy, John



Virological and clinico-pathological features of orf virus infection in experimentally infected rabbits and mice.  


Many aspects of the biology of orf virus (ORFV) infection remain poorly understood and attempts to establish animal models have yielded conflicting and non-reproducible results. We herein describe the characterization of ORFV infection and disease in rabbits and mice. A protocol of intradermal inoculation was employed to inoculate 10(8.5)TCID??/mL of ORFV strain IA-82 in the skin of ears, of the back and labial commissures. All inoculated rabbits presented a clinical course characterized by erythema, macules, papules/vesicles or pustules that eventually dried originating scabs. Local signs started around days 3 and 4 post-inoculation (pi) and lasted 3-10 days. Virus was recovered from lesions between days 2 and 14pi. Histological examination of lesions revealed focal proliferative dermatitis with ballooning degeneration and eosinophilic intracytoplasmic inclusion bodies in keratinocytes, histological hallmarks of contagious ecthyma in sheep. A similar, albeit milder clinical course occurred in 5/10 inoculated mice; virus was recovered from lesions from three animals. Inoculated lambs - used as controls - developed severe lesions of contagious ecthyma. VN tests performed at day 28pi failed to detect neutralizing antibodies in all inoculated animals. In contrast, convalescent rabbit sera were positive by ELISA at dilutions from 100 to 400. These results show that rabbits are susceptible to ORFV infection and thus may be used to study selected aspects of ORFV biology. PMID:20833245

Cargnelutti, J F; Masuda, E K; Martins, M; Diel, D G; Rock, D L; Weiblen, R; Flores, E F



Clinico-epidemiological comparison of delusion prominent and hallucination prominent clinical subgroups of paranoid schizophrenia.  


Background: Though hallucinations and delusions are prominent basic impairments in schizophrenia, reports of the relationship between hallucinatory and delusional symptoms among schizophrenia patients are scant.Aims: To examine the epidemiological and clinical differences between mainly hallucinatory and mainly delusional subgroups of paranoid schizophrenia patients.Methods: One-hundred schizophrenia patients, paranoid type, were recruited. In a cross-sectional study, participants were divided into, Mainly Hallucinatory (H) and Mainly Delusional (D) subgroups.Demographic variables were compared and clinical characteristics, were evaluated using the Schedules for the Assessment of Negative and Positive Symptoms and Clinical Global Impression Scale. Quality-of-Life Enjoyment and Satisfaction Questionnaire-18 was used to assess quality of life.Results: Clinically, the H group was more heterogeneous as expressed by the broader range of scores that described the clinical picture of patients in that subgroup (in 43 of 78 variables 55.13%) and similar ranges of scores (31 of 78 variables - 39.74%) for patients in the D group. Duration of hospitalization was significantly longer in group H than in group D (p-value 0.047). There was no statistically significant difference between the H and D subgroups in demographic characteristics.Conclusions - There are distinct epidemiological and clinical differences between the H and D subgroups with more severe positive and negative symptoms and greater functional impairment in the H group. Paranoid schizophrenia patients with prominent hallucinations have poorer prognosis and need intensive therapeutic rehabilitation beginning with onset-of-illness. Further genetic studies and comparisons of fMRI and/or PET findings is warranted to investigate additional distinctive characteristics of these subgroups. PMID:23518786

Kreinin, Anatoly; Krishtul, Vladimir; Kirsh, Zvi; Menuchin, Michael



Spindle Cell Epithelioma: A Rare Vaginal Tumor -A Clinico Pathologic Report  

PubMed Central

Spindle cell epithelioma is a very rare benign tumour of the vagina, which contains epithelial and mesenchymal components and co-expresses the markers for both. It has its origin in the epithelial cells of the remnants of the vestibular gland. The presence of glandular structures and the pattern of immunostaining, help in the differentiation of these tumours from the other common vaginal tumours.

K., Nivedita; Sowmya; Shanthini, Fatima



Clinico-Microbiological Aspects of Necrotising Fasciitis in Type II Diabetes Mellitus.  


Necrotising fasciitis is insidiously advancing soft tissue infection, characterized by widespread fascial necrosis. One of the most common conditions encountered in the clinical practice and which required clinical suspicion in patients who have less resistance to these infections. Especially in diabetic patients who are more prone for such infection due to low immunity and other reasons like early detection of these infections helps these patients to have a better recovery by aggressive surgical management and other measures required for the same. Literature has enough evidence on how serious this entity. Hence this study is designed in that aspect to help in early diagnosis and appropriate treatment. This study will help to determine the clinical presentation, the polymicrobial involved. The organisms most closely linked to necrotizing fasciitis are group A beta-hemolytic streptococci, although the disease may also be caused by other bacteria and their sensitivity patterns will help us to install appropriate antibiotics with the surgical management. And to compare our mortality rate with the other studies. A prospective descriptive study including all type II diabetic patients with necrotizing fasciitis over 3 years. Patients were evaluated in detail with respect to patient's history, examination, culture sensitivity and chart reviews and followed up using standard evaluation tools to measure the various outcomes. In 62 patients, the commonest clinical presentation was necrotic patch of skin and cellulites. The organisms cultured being beta hemolytic streptococci and E.Coli. The culture sensitivity pattern is to broad-spectrum antibiotics. The average stay in the hospital was about 13.74 days for the study group and the time delay in presentation is 6 days. Wagner's score is a useful tool for aiding the diagnosis. Patients without foot care had extensive lesions. And a mortality rate of 1.6 % in these patients. In an acutely swollen limb in a diabetic patient a high degree of suspicion of necrotizing fasciitis is required. A detailed foot care is warranted in these patients. An early extensive debridement is mandatory and key for a favorable outcome. And to start on broad- spectrum antibiotics is advisable. Wagner's scoring is helpful to predict the chances of a second surgery. With the above entities in mind the mortality rate of necrotizing fasciitis in type ii diabetes mellitus can be contained. PMID:22654326

Bosco Chandra Kumar, Asayas; Subramanyam, S G; Kilpadi, Arun B



[Clinico-social aspects of arterial hypertension in the population of the Karelian ASSR].  


In accordance to the complex programme of "Region" in February-May 1985 mobile medical teams of the Military Academy of Medicine named after S. M. Kirov conducted a sample screening of inhabitants in 15 regions and 2 cities of the Karelian ASSR. Arterial hypertension (AH) was detected in 13.6%, renal arterial hypertension (RAH) in 11.4%, hypertensive disease (HD) in 14.3% of persons screened. It was found that excess body weight considerably increased the risk of HD especially in women under 40 years of age. In 37.1% of persons screened HD was detected for the first time which suggested the need for the improvement of follow-up system for all persons with AH and RAH along with the improvement of screening procedures to provide for more precise diagnoses. PMID:2814647

Polozhentsev, S D; Re?za, V A; Malinski?, D M; Lebedev, M F



A Clinico-Pathological and Immunoparasitological Study on Toxocariasis in Egypt.  

National Technical Information Service (NTIS)

A survey for the detection of the incidence of T.canis and T.cati infection among stray dogs and cats has been performed in Cairo and Giza Governorates. Similarly Toxocariasis in man at Dakahleya Governorate, Siwa Oasis, Qena and Asswan Governorates were ...

H. M. Khalil



Neuromyelitis optica in the old age: a clinico-pathological contribution  

Microsoft Academic Search

We present a case of neuromyelitis optica (NMO) in a previously healthy 64-year-old woman. While CT scan and MRI investigations of the brain as well as myelography were normal, CSF revealed a pathological increase of IgG. Notwithstanding an intensive steroid therapy the patient died after 4 1\\/2 months. Microscopic examination showed, besides extensive demyelination of the optic nerves and spinal

M. Ghezzi; M. Giansanti; G. M. Malentacchi; F. Barontini



Herpes Simplex Virus Type 1 infection: overview on relevant clinico-pathological features.  


Herpes Simplex Virus Type 1 (HSV-1) is a nuclear replicating enveloped virus, usually acquired through direct contact with infected lesions or body fluids (typically saliva). The prevalence of HSV-1 infection increases progressively from childhood, the seroprevalence being inversely related to socioeconomic background. Primary HSV-1 infections in children are either asymptomatic or following an incubation period of about 1 week gives rise to mucocutaneous vesicular eruptions. Herpetic gingivostomatitis typically affects the tongue, lips, gingival, buccal mucosa and the hard and soft palate. Most primary oro-facial HSV infection is caused by HSV-1, infection by HSV-2 is increasingly common. Recurrent infections, which occur at variable intervals, typically give rise to vesiculo-ulcerative lesions at mucocutaneous junctions particularly the lips (herpes labialis). Recurrent HSV-1 infection within the mouth is uncommon in otherwise healthy patients, although in immunocompromised patients, recurrent infection can be more extensive and/or aggressive. The diagnosis of common herpetic infection can usually be based upon the clinical history and presenting features. Confirmatory laboratory diagnosis is, however, required when patients are, or may be, immunocompromised. PMID:18197856

Arduino, Paolo G; Porter, Stephen R



Clinico-pathological significance of hepatitis C virus core antigen levels in chronic infection.  


Hepatitis C virus core antigen (HCVcoreAg) may be measured in serum with a sensitive, recently validated assay. Beyond its value as a marker of viral infection, there are little data on its relation with clinical, histological, and virological parameters. In this study, the significance of HCVcoreAg levels was studied in a prospective cohort of 114 patients with chronic hepatitis C. HCVcoreAg was measured by a commercial chemiluminescent microparticle immunoassay. Clinical and virological data included quantitative HCV-RNA, HCV genotype, ALT, GGT, IL28B rs12979860 polymorphism as well as liver histology parameters. HCVcoreAg levels were correlated significantly with HCV-RNA (r?=?0.56; P?

Durante-Mangoni, Emanuele; Vallefuoco, Luca; Sorrentino, Rosanna; Iossa, Domenico; Perna, Enzo; Molaro, Rosa; Braschi, Umberto; Zampino, Rosa; Sodano, Giuseppe; Adinolfi, Luigi Elio; Utili, Riccardo; Portella, Giuseppe



Clinico-pathological profile of head and neck malignancies at University College Hospital, Ibadan, Nigeria  

Microsoft Academic Search

Introduction  This retrospective study analysed head and neck malignancies seen over a 19-year period at the University College Hospital,\\u000a Ibadan.\\u000a \\u000a \\u000a \\u000a \\u000a Methodology  One thousand, one hundred and ninety two patients with head and neck malignancies were analysed according to age, gender,\\u000a topography and histology.\\u000a \\u000a \\u000a \\u000a \\u000a Results  There was an annual hospital frequency of 62 cases per year. The overall mean age for these malignancies was

Akinyele O Adisa; Bukola F Adeyemi; Abideen O Oluwasola; Bamidele Kolude; Effiong EU Akang; Jonathan O Lawoyin



Epidemiological and clinico-mycological profile of fungal wound infection from largest burn centre in Asia.  


The current study was conducted to know the incidence, predisposing factors, spectrum, clinical profile and antifungal susceptibility (AFS) of fungal wound infection (FWI) in burn patients. Of a total of 71 patients, 20 (28.2%) emerged with the diagnosis of FWI. Fungal pathogens in this study were Candida tropicalis (14%), Candida parapsilosis (5.6%), Aspergillus niger (2.8%) and one each of Candida albicans (1.4%), Candida glabrata (1.4%), Syncephalestrum (1.4%) and Fusarium solani (1.4%). All patients with mould infections expired before the mycological culture results could be conveyed to clinicians. Of the yeasts isolated in the study, one each of C. tropicalis and C. albicans showed cross-resistance to azoles. All the moulds were susceptible to amphotericin B. This study depicted that fungal invasion is associated with a high mortality, burn size 30-60% and high incidence of inhalational injury. Fungal invasion was detected on an average of 14 days after injury. Association of use of four classes of drugs - aminoglycosides, imipenem, vancomycin and third generation cephalosporins and use of total parenteral nutrition was observed. Expedient laboratory diagnosis of FWI and appropriate systemic antifungal therapy guided by AFS may improve outcome for severely injured burn victims. PMID:21740469

Capoor, Malini R; Gupta, Sonal; Sarabahi, Sujata; Mishra, Anshumali; Tiwari, Vinay Kumar; Aggarwal, Pushpa



Clinico-pathological Characteristics of Congenital Pulmonary Lymphangiectasis: Report of Two Cases  

PubMed Central

Congenital pulmonary lymphangiectasis (CPL) is a rare, poorly documented disease, characterized by abnormal dilatation of pulmonary lymphatics without lymphatic proliferation. This disease is seen almost exclusively in infancy and early childhood. It can usually be divided into primary (congenital) and secondary forms. The primary form presents in neonates, and the patients mostly die due to the respiratory distress, shortly after birth. The authors experienced two cases of primary CPL in a 13-day-old male neonate and a one-day-old male neonate, showing prominent lymphatic dilatation in the septal, subpleural, and peri-bronchial tissue throughout both lungs. The latter case was associated with congenital cardiac anomaly including single ventricle. These are unique cases of CPL in Korea of which the diagnosis was established through post-mortem examination. Therefore, the authors report these two cases with primary CPL with a review of the literature.

Eom, Minseob; Choi, Yoo Duk; Kim, Youn Shin; Cho, Mee-Yon; Lee, Han Young



[Effect of microsomal monooxygenase inductor zixoryn on clinico-immunologic indicators in allergologic patients].  


Zixorine, an inducer of microsomal monoxygenases, can effectively be used for the treatment of patients with allergic dermatoses. It has been established that zixorine makes the NBT-test and the IgE content in the blood serum of these patients return to normal. PMID:3576481

Lozovo?, V P; Vol'skii, N N; Nepomniashchikh, V M; Tananko, E M; Nosikova, T A



[Sclerosing epithelial fibrosarcoma: a clinico-morphological evaluation of 10 cases].  


Sclerosing epithelial fibrosarcoma is a malignant mesenchymal tumor (fibroblastic class). It involved tissues of the legs and trunk in patients aged 31-59 and grew slowly as an infiltrative neoplasm during 6-18 months. Relapse occurred in 20% although no metastases were reported. Tumor consisted of epithelial fibroblasts with light cytoplasm and mononuclei. The latter showed low mitotic activity. Fibroblasts came in clusters, bands and alveolar formations sitting in the fibrous stroma. There were small areas consisting of bundles of spindle-shaped fibroblasts with oval hyperchromatic nuclei. Differentiated analysis of epithelioid fibrosarcoma may also be done by computed microscopy and immunomorphology using other tumor models consisting of light-cytoplasm epitheloid cells, mostly osteosarcoma, clear-cell renal carcinoma, melanoma, synovial sarcoma and clear-cell sarcoma of the tendon sheath and aponeurosis. PMID:20020654

Blizniukov, O P; Smirnova, E A



[Clinico-pharmacological research in studying the chronosensitivity to clofelin of hypertension patients].  


In a group of 25 patients with Stage II hypertensive disease, circulatory changes occurring with clofelin, 0.075 mg, were studied in various periods of a day (07.30 a. m. and 0.30, 6.30, and 8.30 p. m.) during acute clinical and pharmacological testing. The findings are indicative of the rhythm of clofelin chronosensitivity, showing its hemodynamic antihypertensive effect provision to be the most beneficial for the body at 6.30 p. m. and to be less at 0.30 p. m. PMID:7696898

Zaslavskaia, R M; Akhmetov, K Zh; Te?blium, M M


Unchanging clinico-epidemiological profile of lung cancer in North India over three decades  

Microsoft Academic Search

Objective: In the recent past, adenocarcinoma has become the commonest histological type of lung cancer (LC) in the developed countries. The present study was conducted to assess the change in epidemiology of LC, if any, in North India. Methods: Prospectively collected data on 250 newly diagnosed LC patients presenting to a tertiary care institute was analyzed. Results were compared with

Navneet Singh; Ashutosh N. Aggarwal; Dheeraj Gupta; Digambar Behera; Surinder K. Jindal



Unilateral left paramedian infarction of thalamus and midbrain: a clinico-pathological study  

Microsoft Academic Search

In a patient with a unilateral embolic infarct in the left posterior thalamo-subthalamic paramedian artery territory, neuropathological studies showed involvement of the intralaminar, dorsomedial, and internal part of the ventral posterior nuclei of the thalamus, of the rostral part of the mesencephalic reticular formation, and of the posterior commissure. The patient showed upgaze palsy for voluntary saccades, smooth pursuit and

J Bogousslavsky; J Miklossy; J P Deruaz; F Regli; G Assal



Acute megakaryoblastic leukaemia: a clinico-haematological profile of five cases.  


Herein we are presenting the clinical, morphological and cytochemical characteristics of five cases of acute megakaryoblastic leukaemia (AML-M7) seen by us over a period of five years (Jan 1996-Dec 2000). Morphological assessment revealed marked polymorphism of blast cells and platelets both in the peripheral blood and bone marrow smears in all cases. Size of the blast cells ranged from very small to very large multinucleated cells, with variable chromatin pattern and number of nucleoli. More differentiated megakaryocytic cells showing cytoplasmic blebs, protrusions and platelet budding with bizarre platelet morphology were characteristic features suggesting the diagnosis. Cytochemical stains like myeloperoxidase, sudan black and PAS were positive in 5-15% of blast cell. Coagulation studies revealed a normal coagulation profile, whereas platelet studies showed marked impairment in aggregation of platelets with ADP and adrenalin with a normal PF-3 availability. PMID:16295495

Shukla, Jyoti; Rai, Sunita; Singh, V P



Chronic thinner intoxication: clinico-pathologic report of a human case.  

PubMed Central

A 27 year old Mexican male addicted for 12 years to glue-sniffing and thinner inhalation developed neurological and behavioural disturbances which led to hospital admission and death. Autopsy disclosed diffuse cerebral and cerebellar cortex atrophy and giant axonopathy both central and peripheral. The corpus callosum was atrophic secondarily to neuron loss in the neocortex. Images

Escobar, A; Aruffo, C



Visual associative agnosia: a clinico-anatomical study of a single case  

Microsoft Academic Search

A single case study of a patient with visual associative agnosia is described. The patient had well preserved language, spatial, visual, and perceptual abilities but nevertheless was impaired in recognising visually presented common objects. It is argued that his deficit cannot be accounted for in terms of a disconnection syndrome. Behavioural and anatomical (MRI scan) evidence for focal unilateral dysfunction

R A McCarthy; E. K. Warrington



[Clinico-morphological changes in a burn wound after electric stimulation with pulsatile current].  


The healing of sluggishly postburn wounds after local electrostimulation (ES) with the use of current-conducting carbon tissue as the electrode was studied in 12 patients. Analysis of the clinical data which were corroborated by the results of morphological and biochemical studies confirmed the marked stimulating effect of local ES which facilitates successful taking of dermal autografts and healing of burn wounds. The obtained data are evidence that the method of ES through a current-conducting carbon tissue is promising in the complex of measures for local treatment of burn wounds. PMID:2273856

Adamian, A A; Shloznikov, B M; Muzykant, L I; Za?denberg, M A; Gogiia, B Sh; Kashin, Iu D



A Clinico-Epidemiological Study of Macular Amyloidosis from North India  

PubMed Central

Background: Macular amyloidosis (MA) is the most subtle form of cutaneous amyloidosis, characterized by brownish macules in a rippled pattern, distributed predominantly over the trunk and extremities. MA has a high incidence in Asia, Middle East, and South America. Its etiology has yet to be fully elucidated though various risk factors such as sex, race, genetic predisposition, exposure to sunlight, atopy and friction and even auto-immunity have been implicated. Aim: This study attempts to evaluate the epidemiology and risk factors in the etiology of MA. Materials and: Methods: Clinical history and risk factors of 50 patients with a clinical diagnosis of MA were evaluated. Skin biopsies of 26 randomly selected patients were studied for the deposition of amyloid. Results: We observed a characteristic female preponderance (88%) with a female to male ratio of 7.3:1, with a mean age of onset of MA being earlier in females. Upper back was involved in 80% of patients and sun-exposed sites were involved in 64% cases. Incidence of MA was high in patients with skin phototype III. Role of friction was inconclusive Conclusion: Lack of clear-cut etiological factors makes it difficult to suggest a reasonable therapeutic modality. Histopathology is not specific and amyloid deposits can be demonstrated only in a small number of patients. For want of the requisite information on the natural course and definitive etiology, the disease MA remains an enigma and a source of concern for the suffering patients.

Bandhlish, Anshu; Aggarwal, Asok; Koranne, Ravinder V



Orbital plasmablastic lymphoma: a clinico-pathological correlation of a rare disease and review of literature  

PubMed Central

Ocular involvement by plasmablastic lymphoma is extremely rare with very few reports in the literature. Its morphological and immunological resemblance to plasma cell myeloma makes it a diagnostic challenge, while its clinical course, which is characterized by recurrence and death, makes therapy a challenge for clinicians. We present three cases of plasmablastic lymphoma, each of which has distinct clinicoradiological features, and we also review the literature on orbital plasmablastic lymphomas.

Mulay, Kaustubh; Ali, Mohammad Javed; Reddy, Vijay Anand; Honavar, Santosh G



Emofilia A acquisita: descrizione di un caso clinico in età geriatrica  

Microsoft Academic Search

Acquired hemophilia is a rare coagulopathy in adults, associated with bleeding complications. Although the etiology of this disorder remains obscure, an autoimmune mechanism produces the development of autoantibodies against factor VIII. About half of cases are associated with other conditions, mainly post-partum, underlying cancer, autoimmune disease. An 81-year-old male was admitted to the hospital with extensive hematomas (neck, chest, arms

Walter Boddi; Stefania Machetti; Nicola Sodi; Lucia Sammicheli; Graziella Cati; Giovanna Marotta; Laura Sabatini; Roberto Cappelli



Clinico-biochemical studies on acute toxic nephropathy in goats due to uranyl nitrate  

Microsoft Academic Search

Acute toxic nephropathy was produced in 6 healthy goats by injecting intravenously 1% uranyl nitrate (UN) (15 mg\\/kg body weight). The early painful clinical signs simulating shock progressed with subnormal temperature, slow-shallow respiration and arrhythmic pulse followed by death due to respiratory failure within 96 to 120 hr. All the affected goats had normocytic normochromic anemia, leucocytosis, neutrophilia with left

P. K. Dash; H. C. Joshi



Clinico-biochemical studies on acute toxic nephropathy in goats due to uranyl nitrate  

SciTech Connect

Acute toxic nephropathy was produced in 6 healthy goats by injecting intravenously 1% uranyl nitrate (UN) (15 mg/kg body weight). The early painful clinical signs simulating shock progressed with subnormal temperature, slow-shallow respiration and arrhythmic pulse followed by death due to respiratory failure within 96 to 120 hr. All the affected goats had normocytic normochromic anemia, leucocytosis, neutrophilia with left shift eosinopenia, decreased monocytes and presence of 1-2% reticulocytes in the peripheral blood smears. On blood chemical analysis, a uniform and continuous rise was seen in serum creatinine with a concomitant daily increase of serum urea and uric acid. Simultaneous analysis of urine indicated polyuria leading to oliguria, acidic pH, albuminuria, glycosuria with presence of neutrophils, RBC's, epithelial and fatty casts, increase of triple phosphate, and cystine crystals reflecting acute damage of kidneys in the affected goats.

Dash, P.K.; Joshi, H.C.



Clinico-biochemical studies on acute toxic nephropathy in goats due to uranyl nitrate.  


Acute toxic nephropathy was produced in 6 healthy goats by injecting intravenously 1% uranyl nitrate (UN) (15 mg/kg body weight). The early painful clinical signs simulating shock progressed with subnormal temperature, slow-shallow respiration and arrhythmic pulse followed by death due to respiratory failure within 96 to 120 hr. All the affected goats had normocytic normochromic anemia, leucocytosis, neutrophilia with left shift eosinopenia, decreased monocytes and presence of 1-2% reticulocytes in the peripheral blood smears. On blood chemical analysis, a uniform and continuous rise was seen in serum creatinine with a concomitant daily increase of serum urea and uric acid. Simultaneous analysis of urine indicated polyuria leading to oliguria, acidic pH, albuminuria, glycosuria with presence of neutrophils, RBC's, epithelial and fatty casts, increase of triple phosphate, and cystine crystals reflecting acute damage of kidneys in the affected goats. PMID:2711608

Dash, P K; Joshi, H C



Clinico-radiologic findings of entrapped inferior oblique muscle in a fracture of the orbital floor.  


A 51-year old man presented with vertical and torsional diplopia after reduction of a blowout fracture at another hospital one year ago. He had no anormalies of head position and 14 prism diopters (PD) right hypertropia (RHT) in the primary position. In upgaze no vertical deviation was found, and hyperdeviation on downgaze was 35PD. Bielschowsky head tilt test showed a negative response. Distinct superior oblique (SO) and inferior rectus (IR) underaction of the right eye was noted but IO overaction was mild on the ocular version test. Double Maddox rod test (DMRT) revealed 10-degree extorsion, but fundus extorsion was minimal in the right eye.Thin-section coronal CT scan showed that there was no fracture line on the anterior orbital floor, but a fracture remained on the posterior orbital floor. Also, the anterior part of the right inferior oblique muscle was vertically reoriented and the medial portion of the inferior oblique muscle was not traced on the coronal CT scan. The patient underwent 14 mm right IO recession and 3 mm right IR resection. One month after the surgery, his vertical and torsional diplopia were eliminated in the primary position. PMID:19794954

Kim, Soo; Kim, Taik-Kun; Kim, Seung-Hyun



Insights into thermoregulation: a clinico-radiological description of Shapiro syndrome.  


Shapiro syndrome is a rare entity, comprising a triad of recurrent hypothermia, hyperhidrosis and congenital agenesis of the corpus callosum. Fewer than 50 cases have been described, almost invariably in patients presenting in childhood or early adulthood. We present a case of an 80 year old woman presenting with recurrent bouts of shivering, sweating and profound malaise, who sought medical attention because the frequency and severity of attacks worsened in her later years. MRI Brain demonstrated agenesis of the corpus callosum; a rigorous work-up excluded other causes for her symptomatology. The intricate interplay of neuronal networks involved in thermoregulation remains to be fully elucidated and as such, little is known about the pathophysiological mechanisms underlying the clinical manifestations of Shapiro syndrome. We present novel data from FDG-PET imaging of our patient, demonstrating hypermetabolism in a number of brainstem and cerebellar regions during the symptomatic phase. These findings imply that aberrant thermoregulation in Shapiro syndrome involves a number of structures remote from the callosal region. We also present neuropsychometric findings in our patient, of which there have been no reports to date. We postulate that the ageing brain may be more susceptible to the paroxysmal neurochemical fluxes implicated in the syndrome. PMID:23578790

Pazderska, Agnieszka; O'Connell, Martin; Pender, Niall; Gavin, Claire; Murray, Brian; O'Dowd, Seán



A new clinico-pathological classification system for mesial temporal sclerosis  

PubMed Central

We propose a histopathological classification system for hippocampal cell loss in patients suffering from mesial temporal lobe epilepsies (MTLE). One hundred and seventy-eight surgically resected specimens were microscopically examined with respect to neuronal cell loss in hippocampal subfields CA1–CA4 and dentate gyrus. Five distinct patterns were recognized within a consecutive cohort of anatomically well-preserved surgical specimens. The first group comprised hippocampi with neuronal cell densities not significantly different from age matched autopsy controls [no mesial temporal sclerosis (no MTS); n = 34, 19%]. A classical pattern with severe cell loss in CA1 and moderate neuronal loss in all other subfields excluding CA2 was observed in 33 cases (19%), whereas the vast majority of cases showed extensive neuronal cell loss in all hippocampal subfields (n = 94, 53%). Due to considerable similarities of neuronal cell loss patterns and clinical histories, we designated these two groups as MTS type 1a and 1b, respectively. We further distinguished two atypical variants characterized either by severe neuronal loss restricted to sector CA1 (MTS type 2; n = 10, 6%) or to the hilar region (MTS type 3, n = 7, 4%). Correlation with clinical data pointed to an early age of initial precipitating injury (IPI < 3 years) as important predictor of hippocampal pathology, i.e. MTS type 1a and 1b. In MTS type 2, IPIs were documented at a later age (mean 6 years), whereas in MTS type 3 and normal appearing hippocampus (no MTS) the first event appeared beyond the age of 13 and 16 years, respectively. In addition, postsurgical outcome was significantly worse in atypical MTS, especially MTS type 3 with only 28% of patients having seizure relief after 1-year follow-up period, compared to successful seizure control in MTS types 1a and 1b (72 and 73%). Our classification system appears suitable for stratifying the clinically heterogeneous group of MTLE patients also with respect to postsurgical outcome studies.

Pauli, Elisabeth; Clusmann, Hans; Schramm, Johannes; Becker, Albert; Elger, Christian; Merschhemke, Martin; Meencke, Heinz-Joachim; Lehmann, Thomas; von Deimling, Andreas; Scheiwe, Christian; Zentner, Josef; Volk, Benedikt; Romstock, Johann; Stefan, Hermann; Hildebrandt, Michelle



[Diabetic ophthalmoplegia--a clinico-pathological study of the first case in Japan].  


Many reports of diabetic ophthalmoplegia have been published from the clinical points of view. However, there have been only three autopsied cases in which the ocular nerves were investigated histopathologically. A 72-year-old housewife was diagnosed to have glycosuria at the age of 67, but no medical treatment was done. She admitted to the hospital, because of acute onset of right eyelid drooping and diplopia for previous four days. She showed complete eyelid ptosis, moderate dilatation of right pupil, loss of light reaction, and extraocular muscle palsy except abduction on the right. Blood pressure was normal. A glucose tolerance test was diabetic and HbA1c was moderately increased. Her diabetes was fairly well-controlled with a diet therapy and injection of lente insulin. Two and a half months after admission, the course of illness became regressive. Seven months later, external ophthalmoplegia was disappeared and only slight anisocoria was seen. She readmitted to the hospital one year and eleven months later, because of anorexia and emaciation. She died of adenocarcinoma of the stomach without chemotherapy. The duration from onset of ocular symptoms to death was two years and one month. At postmortem examination, stomach cancer infiltrated extensively to the abdominal and pelvic viscera, but no metastasis to the nervous system or intraorbital tissues was found. There were mild to moderate atherosclerotic changes in the small-and middle-sized arteries of the kidneys, pancreas and adrenal glands corresponding to her age. Moderate atherosclerosis was found in all of the major arteries including Willis ring, siphon of the right internal carotid artery and Vertebro-basilar one.(ABSTRACT TRUNCATED AT 250 WORDS) PMID:2692931

Usui, Y; Mukoyama, M; Hashizume, M; Takahashi, A



[Peculiar clinico-diagnostic features of ischemic stroke in subjects employed in "hazardous" occupations].  


The aim of the study is to analyse the structure, clinical course, and outcomes of ischemic stroke in neuorologic departments of a specialized clinic for optimization of preventive and rehabilitative treatment in patients of hazardous employment, such as servicemen, peace-keepers, members of special force and counter-terrorism action groups, participants of local wars, and armed conflicts. A total of 242 acute ischemic cerebrovascular attacks were analysed using data from case records for 2004 to 2007. The frequency of stroke was estimated with reference to age, gender, risk factors, social status, and subtypes of ischemic stroke. The role of risk factors, such as ischemic heart disease, cardioarrythmia, hypertensive disease, and diabetes mellitus, in the development of different subtypes of ischemic stroke was assessed. It was shown that medical services of the clinic manage to achieve a greater reduction of the lethality rate compared with other domestic and foreign hospitals. A lower disability rate is probably attributable to adequate primary preventive treatment in the prehospitalization period and active therapy in the acute phase of stroke. The lethality rate is highest among patients with cardioembolic stroke which suggests the necessity to improve preventive treatment of men with cardioarrhythmia. Close relationship between lethality and risk factors underscores the importance of multidisciplinary management of patients with ischemic stroke. PMID:19469255

Khozhenko, E V



Infected foot ulcers in male and female diabetic patients: a clinico-bioinformative study  

Microsoft Academic Search

BACKGROUND: The study aimed at (i) characterizing the mode of transmission of blaCTX-M and blaTEM-1 among extended-spectrum-?-lactamase (ESBL)-producing Escherichia coli strains isolated from infected diabetic foot ulcers, and (ii) identifying the risk factors for \\

Shazi Shakil; Asad U Khan



Clinico-pathological investigations of Rasmussen encephalitis suggest multifocal disease progression and associated focal cortical dysplasia.  


Rasmussen encephalitis is a devastating neurological disorder characterised by seizures, brain inflammation, and progressive hemispheric atrophy. The objective of the current study was to systematically characterise patterns of structural lesions in children with Rasmussen encephalitis, referred for modified anatomical hemispherectomy at the Tsinghua University Epilepsy Center in Beijing. Seven consecutive patients were investigated with a mean age at operation of 4.5 years, who suffered from medically intractable seizures for a mean of 1.6 years. Foci of abnormally increased T2 signal intensity were observed in all patients. With the exception of one child, all patients presented with progressive unilateral cerebral atrophy. FDG-PET imaging revealed extensive regions of hypometabolism within the affected cerebral hemisphere in 3 of 4 patients. Diagnosis of Rasmussen encephalitis was confirmed histologically, demonstrating CD68 positive microglial nodules, as well as CD3 and CD8 positive T lymphocytes invading the cerebral parenchyma. An intriguing observation was the heterogenous distribution of patterns of lesions throughout the affected hemisphere, suggesting multifocal manifestation and distinct sequences of disease progression, from discrete foci of inflammatory infiltrates (stage 1) to extensive cortical destruction (stage 4). Atypical hippocampal sclerosis (HS), with neuronal cell loss affecting most prominently the CA4 region (HS type 3 or end folium sclerosis), was evident in 5 of 7 cases. Four hippocampi also showed chronic inflammation. In addition, we observed associated focal cortical dysplasia (FCD; ILAE type IIId) in 4 of 7 children, supporting the concept of acquired and postmigratory FCD pathomechanisms. Postsurgical seizure freedom was achieved in all children with a mean follow-up period of 2.7 years and continuous antiepileptic medication. PMID:23531608

Wang, Dandan; Blümcke, Ingmar; Gui, Qiuping; Zhou, Wenjing; Zuo, Huancong; Lin, Jiuluan; Luo, Yang



Clinico-pathogenetic findings and management of chondrodystrophic myotonia (Schwartz-Jampel syndrome): a case report  

Microsoft Academic Search

BACKGROUND: Chondrodystrophic myotonia or Schwartz-Jampel syndrome is a rare genetic disorder characterized by myotonia and skeletal dysplasia. It may be progressive in nature. Recently, the gene responsible for Schwartz-Jampel syndrome has been found and the defective protein it encodes leads to abnormal cartilage development and anomalous neuromuscular activity. CASE PRESENTATION: We report the clinical findings and the management of an

Nicola C Ho; Stacey Sandusky; Victor Madike; Clair A Francomano; Marinos C Dalakas



Clinico-pathogenetic findings and management of chondrodystrophic myotonia (Schwartz-Jampel syndrome): a case report  

PubMed Central

Background Chondrodystrophic myotonia or Schwartz-Jampel syndrome is a rare genetic disorder characterized by myotonia and skeletal dysplasia. It may be progressive in nature. Recently, the gene responsible for Schwartz-Jampel syndrome has been found and the defective protein it encodes leads to abnormal cartilage development and anomalous neuromuscular activity. Case Presentation We report the clinical findings and the management of an 8-year-old boy with this disorder. The molecular findings confirm that the patient is a compound heterozygote with a different splicing mutation in each Perlecan allele. This resulted in a significant reduction in the production of the encoded normal protein. Conclusion We discuss the multi-disciplinary management of Schwartz-Jampel syndrome that will facilitate optimal care and timely intervention of patients with this disorder.

Ho, Nicola C; Sandusky, Stacey; Madike, Victor; Francomano, Clair A; Dalakas, Marinos C



Clinico-Pathological Discrepancies in a General University Hospital in S?o Paulo, Brazil  

PubMed Central

INTRODUCTION The autopsy rate has continuously diminished over the past few decades, reducing the quality of medical care and the accuracy of statistical health data. OBJECTIVE To assess the accuracy of clinical diagnoses by comparing pre- and postmortem findings, and to identify potential risk factors for misdiagnoses. METHODS Retrospective evaluations performed between June 2001 and June 2003 in a 2500-bed tertiary university hospital in São Paulo, Brazil, including 288 patients who died at that institution and had a postmortem examination. RESULTS Clinical and autopsy records were reviewed and compared for categorization using the adapted Goldman criteria. The overall major and minor discrepancy rates were 16.3% and 28.1%, respectively. The most common missed diagnoses were pulmonary embolism, pneumonia, and myocardial infarction, and the most prevalent underlying diseases were infectious diseases, cerebro-cardiovascular conditions, and malignancies. Patients age 60 or older had an increased risk of diagnostic disagreement, as did female patients. The period of hospitalization, last admission unit at the hospital and underlying disease were not significantly related to the pre-mortem diagnostic accuracy. DISCUSSION The discrepancy rate found in this study is similar to those reported globally. The factors influencing diagnostic accuracy as well as the most commonly missed diagnoses are also consistent with the literature. CONCLUSION Autopsy remains a crucial tool for improving medical care, and effort must be focused on increasing its practice worldwide.

Kotovicz, Fabiana; Mauad, Thais; Saldiva, Paulo H. N.



Co-adsorptions of CO/N2O, NO/NH3, CO2/N2 and conversion of CO/N2O to CO2/N2 on ZnO graphene-like nanosheet  

NASA Astrophysics Data System (ADS)

Adsorption energies of CO, CO2, N2O, N2, NO, NH3 and CO/N2O, NO/NH3 and CO2/N2 co-adsorptions on the ZnO graphene-like nanosheet (ZnOGLNS) were obtained using DFT calculations. The energies and thermodynamic properties for conversion of CO + N2O to CO2 + N2 over the ZnOGLNS, its equilibrium constant and adsorption coefficients are reported. The activation energy for the conversion reaction of CO + N2O to CO2 + N2 over the ZnOGLNS of 42.30 kcal/mol was obtained. The CO + N2O to CO2 + N2 conversion over the ZnOGLNS is the energetically and thermodynamically preferred reaction.

Kaewruksa, Benjawan; Wanbayor, Raina; Ruangpornvisuti, Vithaya



[Intracranial hypertension related to sedation with sevoflurane using the AnaConDa(®) device in a patient with severe traumatic brain injury].  


Sedation in neurocritical patients remains a challenge as there is no drug that meets all the requirements. Since the appearance of the AnaConDa(®) device, and according to the latest recommendations, sevoflurane has become an alternative for patients with brain injury. The use of AnaConDa(®) produces an increase in the anatomical dead space that leads to a decrease in alveolar ventilation. If the decrease in the alveolar ventilation is not offset by an increase in minute volume, there will be an increase in PaCO2. We report the case of a patient with severe traumatic brain injury who suffered an increase in intracranial pressure as a result of increased PaCO2 after starting sedation with the AnaConDa(®) device. PMID:22920835

Ferrando, C; Carbonell, J A; Aguilar, G; Badenes, R; Belda, F J



Lectin from Canavalia brasiliensis (ConBr) protects hippocampal slices against glutamate neurotoxicity in a manner dependent of PI3K/Akt pathway.  


The excitotoxicity induced by excessive activation of the glutamatergic neurotransmission pathway is involved in several neuropathologies. In this sense, molecules that prevent the release of glutamate or the excessive activation of its receptors can be useful in preventing the neuronal cell death observed in these diseases. Lectins are proteins capable of reversible binding to the carbohydrates in glycoconjugates, and some have been used in the study and purification of glutamate receptors. ConBr is a mannose/glucose-binding lectin purified from Canavalia brasiliensis seeds. In the present study, we aimed to evaluate the neuroprotective activity of ConBr against glutamate-induced excitotoxicity. Hippocampal slices were isolated from adult male mice and incubated for 6h in Krebs saline/DMEM buffer alone (control), in the presence of glutamate or glutamate plus ConBr. The phosphorylation of Akt and mitogen activated protein kinases (MAPKs) such as ERK1/2, p38(MAPK) and JNK1/2/3 was evaluated with western blotting. The results indicate that glutamate provoked a reduction in the hippocampal slice viability (-25%), diminished the phosphorylation of Akt and augmented p38(MAPK) and ERK1 phosphorylation. No changes were observed in the phosphorylation of JNK1/2/3 or ERK2. Notably, ConBr, through a mechanism dependent on carbohydrate interaction, prevented the reduction of cell viability and Akt phosphorylation induced by glutamate. Furthermore, in the presence of the PI3K inhibitor LY294002, ConBr was unable to reverse glutamate neurotoxicity. Taken together, our data suggest that the neuroprotective effect of ConBr against glutamate neurotoxicity requires oligosaccharide interaction and is dependent on the PI3K/Akt pathway. PMID:23454192

Jacques, Amanda V; Rieger, Débora K; Maestri, Mariana; Lopes, Mark W; Peres, Tanara V; Gonçalves, Filipe M; Pedro, Daniela Z; Tasca, Carla I; López, Manuela G; Egea, Javier; Nascimento, Kyria S; Cavada, Benildo S; Leal, Rodrigo B



Preventive effects of 1,25-(OH)2VD3 against ConA-induced mouse hepatitis through promoting vitamin D receptor gene expression  

Microsoft Academic Search

Aim:To investigate the immunosuppressive effects of 1,25-dihydroxyvitamin D3 (1,25-(OH)2VD3) on concanavalin A (ConA)-induced hepatitis and elucidate the action mechanism.Methods:Female BALB\\/C mice were intravenously administered ConA (20 mg\\/kg) to induce acute immunological liver injury. Liver damage was evaluated in respect to serum alanine transaminase (ALT) level and liver histological changes. The proliferation of splenocytes was measured by using [3H]-thymidine incorporation. The

Xu-dong Hu; Shi-li Jiang; Cheng-hai Liu; Yi-yang Hu; Cheng Liu; Ming-yu Sun; Gao-feng Chen; Ping Liu



Crystal structure of [Co(N 2 C 2 H 8 ) 3 ] [AuBr 4 ] 2 Br bis (tetrabromoaurate(III)) tris (ethylenediamine) cobalt(III) bromide  

Microsoft Academic Search

A double complex salt [Co(N2C2H8)3][AuBr4]2Br is obtained and characterized using single crystal X-ray diffraction analysis. The crystallographic data of C6H24Au2Br9CoN6 are as follows: a = 21.6479(17) Å, b = 14.9085(12) Å, c = 8.2676(7) Å, ? = 110.820(2)°, V = 1538.92(12) Å3, C2\\/c space group, Z = 4, d\\u000a x = 3.602 g\\/cm3. Square planar coordination of the gold atom

I. A. Baidina; E. V. Makotchenko



Synthesis, growth, structural, spectral, thermal, chemical etching, linear and nonlinear optical and mechanical studies of an organic single crystal 4-chloro 4-nitrostilbene (CONS): a potential NLO material.  


4-Chloro 4-nitrostilbene (CONS) a new organic nonlinear optical material has been synthesized. Employing slow evaporation method, good optical quality single crystals (dimensions up to 6×2×3 mm(3)) have been grown using ethyl methyl ketone (EMK) as a solvent. The grown crystals have been subjected to various characterizations such as single crystal X-ray diffraction, powder XRD, Fourier Transform Infrared spectroscopy (FTIR), proton NMR, solid UV absorption, SHG studies. Single crystal X-ray diffraction reveals that the crystal system belongs to monoclinic with noncentrosymmetric space group P21. The UV-Vis absorption spectrum has been recorded and found that the cut off wavelength is 380 nm. Functional groups and the structure of the title compound have been confirmed by FTIR and (1)H NMR spectroscopic analyses respectively. Molecular mass of the CONS confirmed by the high resolution mass spectral analysis .The thermal behavior of the grown crystal has been studied by TG/DTA analysis and it shows the melting point is at 188.66 °C. Dislocations and growth pattern present in the grown crystal revealed by the etching study. The mechanical strength of the CONS crystal has been studied by Vicker's hardness measurement. The SHG efficiency of the grown crystal has been determined by Kurtz and Perry powder test which revealed that the CONS crystal (327 mV) has 15 times greater efficiency than that of KDP (21.7 mV). PMID:23624038

Dinakaran, Paul M; Kalainathan, S



Synthesis, growth, structural, spectral, thermal, chemical etching, linear and nonlinear optical and mechanical studies of an organic single crystal 4-chloro 4-nitrostilbene (CONS): A potential NLO material  

NASA Astrophysics Data System (ADS)

4-Chloro 4-nitrostilbene (CONS) a new organic nonlinear optical material has been synthesized. Employing slow evaporation method, good optical quality single crystals (dimensions up to 6 × 2 × 3 mm3) have been grown using ethyl methyl ketone (EMK) as a solvent. The grown crystals have been subjected to various characterizations such as single crystal X-ray diffraction, powder XRD, Fourier Transform Infrared spectroscopy (FTIR), proton NMR, solid UV absorption, SHG studies. Single crystal X-ray diffraction reveals that the crystal system belongs to monoclinic with noncentrosymmetric space group P21. The UV-Vis absorption spectrum has been recorded and found that the cut off wavelength is 380 nm. Functional groups and the structure of the title compound have been confirmed by FTIR and 1H NMR spectroscopic analyses respectively. Molecular mass of the CONS confirmed by the high resolution mass spectral analysis .The thermal behavior of the grown crystal has been studied by TG/DTA analysis and it shows the melting point is at 188.66 °C. Dislocations and growth pattern present in the grown crystal revealed by the etching study. The mechanical strength of the CONS crystal has been studied by Vicker's hardness measurement. The SHG efficiency of the grown crystal has been determined by Kurtz and Perry powder test which revealed that the CONS crystal (327 mV) has 15 times greater efficiency than that of KDP (21.7 mV).

Dinakaran, Paul M.; Kalainathan, S.




Microsoft Academic Search

La selección recurrente para aptitud combinatoria en cultivos autógamos (SRAC), aunque exitosa, enfrenta dificultades para ha- cer las cruzas y para obtener suficiente semilla de éstas. Además, las derivaciones de la respuesta a la SRAC (R) basadas en el mode- lo de dos alelos pueden no ser adecuadas si la población se formó con más de dos progenitores. El objetivo

Jaime Sahagún-Castellanos; Autónoma Chapingo



An Exploratory Study of the W3C Mailing List Test Collection for Retrieval of Emails with Pro\\/Con Argument  

Microsoft Academic Search

The W3C mailing list test collection, an information re- trieval test collection for email, was developed for the TREC Enterprise Search track in 2005. One task in that track was to retrieve emails that contribute at least one pro\\/con related to a specific topic. This paper describes the test collection and presents a preliminary evaluation of its suit- ability for

Yejun Wu; Douglas W. Oard; Ian Soboroff



High mobility group box chromosomal protein 1 in acute-on-chronic liver failure patients and mice with ConA-induced acute liver injury.  


High mobility group box chromosomal protein 1 (HMGB1) is an important proinflammatory molecule in many inflammatory disorders, but little is known about its role in acute-on-chronic liver failure (ACLF). Here, we investigated the relationship between the expression of HMGB1 and the disease onset and severity of ACLF patients and mice with acute liver injury/failure induced by concanavalin A (ConA). Peripheral blood mononuclear cells (PBMCs) and serum from ACLF patients were collected, and a mouse model of acute liver injury/failure was induced by ConA. HMGB1 mRNA expression in patient PBMCs or in murine livers and serum HMGB1 protein in ACLF patients and mice were assayed by RT-PCR and Western blotting, respectively. HMGB1 translocation in hepatocytes of ConA-treated mice was assessed by immunohistochemical staining. Up-regulated HMGB1 mRNA levels in PBMCs and accumulated protein in serum were both correlated with disease severity in ACLF patients. In the animal model, HMGB1 levels increased at 4 h and reached its peak value at 8-12 h after challenge with ConA, which suggests that HMGB1 is a relatively late proinflammatory cytokine compared with TNF-?. Translocation of HMGB1 from the nucleus to the cytoplasm in hepatocytes was correlated with the severity of liver injury in mice. While specific anti-HMGB1 antibodies and nicotine protected mice from acute liver injury/failure by reducing mortality and improving liver tissue injury, treatment with recombinant HMGB1 led to an increased mortality due to ConA challenge. Thus, the data from the present study suggest that HMGB1 plays a critical role in the systemic inflammation of ACLF and could be a potential therapeutic target in the treatment of ACLF. PMID:22609241

Zhou, Rong-Rong; Liu, Hong-Bo; Peng, Jian-Ping; Huang, Yan; Li, Ning; Xiao, Mei-Fang; Wang, Haichao; Fan, Xue-Gong



Use of a GnRH vaccine, GonaCon, for prevention and treatment of adrenocortical disease (ACD) in domestic ferrets.  


Adrenocortical disease (ACD) is a common problem in surgically sterilized, middle-aged to old ferrets (Mustela putorius furo). The adrenal tissues of these ferrets develop hyperplasia, adenomas, or adenocarcinomas, which produce steroid hormones including estradiol, 17-hydroxyprogesterone, and androstenedione. Major clinical signs attributable to overproduction of these hormones are alopecia (hair loss) in both sexes and a swollen vulva in females. Pruritus, muscle atrophy, hind limb weakness, and sexual activity or aggression are also observed in both sexes. Males can develop prostatic cysts, prostatitis, and urethral obstruction. ACD is thought to be linked to continuous and increased LH secretion, due to lack of gonadal hormone feedback in neutered ferrets. This continuous elevated LH acts on adrenal cortex LH receptors, resulting in adrenal hyperplasia or adrenal tumor. This study investigated whether the immunocontraceptive vaccine GonaCon, a GnRH vaccine developed to reduce the fertility of wildlife species and the spread of disease, could prevent or delay onset of ACD and treat alopecia in ferrets with existing ACD. Results showed that GonaCon provided relief from ACD by causing production of antibodies to GnRH, probably suppressing production and/or release of LH. Treatment caused many ACD symptoms to disappear, allowing the ferrets to return to a normal life. The study also found that the probability of developing ACD was significantly reduced in ferrets treated with GonaCon when young (1-3 years old) compared to untreated control animals. GonaCon caused injection site reaction in some animals when administered as an intramuscular injection but caused few side effects when administered subcutaneously. Both intramuscular and subcutaneous vaccination resulted in similar levels of GnRH antibody titers. Subcutaneous vaccination with GonaCon is thus recommended to prevent the onset of ACD and as a possible treatment for ACD-signs in domestic ferrets. PMID:23906891

Miller, Lowell A; Fagerstone, Kathleen A; Wagner, Robert A; Finkler, Mark



Tissue factor expression in ovarian cancer: implications for immunotherapy with hI-con1, a factor VII-IgGFc chimeric protein targeting tissue factor  

PubMed Central

We evaluated the expression of tissue factor (TF) in ovarian cancer (EOC) and the potential of hI-con1, an antibody-like molecule targeting TF, as a novel form of therapy against chemotherapy-resistant ovarian disease. We studied the expression of TF in 88 EOC by immunohistochemistry (IHC) and real-time-PCR (qRT-PCR) and the levels of membrane-bound-complement-regulatory-proteins CD46, CD55 and CD59 in primary EOC cell lines by flow-cytometry. Sensitivity to hI-con1-dependent-cell-mediated-cytotoxicity (IDCC), complement-dependent-cell-cytotoxicity and inhibition of IDCC by ?-immunoglobulin were evaluated in 5-h 51chromium-release-assays. Cytoplasmic and/or membrane TF expression was observed in 24 out of 25 (96%) of the EOC samples tested by IHC, but not in normal ovarian-tissue. EOC with clear cell histology significantly overexpress TF when compared to serous, endometrioid, or undifferentiated tumors by qRT-PCR. With a single exception, all primary EOC that overexpressed TF demonstrated high levels of CD46, CD55 and CD59 and regardless of their histology or resistance to chemotherapy, were highly sensitive to IDCC. The effect of complement and physiologic doses of ?-immunoglobulin on IDCC in ovarian cancer cell lines overexpressing TF was tumor specific and related to the overexpression of CD59 on tumor cells. Small-interfering-RNA-mediated knockdown of CD59 expression in ovarian tumors significantly increased hI-con1-mediated cytotoxic activity in vitro. Finally, low doses of interleukin-2 further increased the cytotoxic effect induced by hI-con1 (P < 0.01). hI-con1 molecule induces strong cytotoxicity against primary chemotherapy-resistant ovarian cancer cell lines overexpressing TF and may represent a novel therapeutic agent for the treatment of ovarian tumors refractory to standard treatment modalities.

Cocco, Emiliano; Varughese, Joyce; Buza, Natalia; Bellone, Stefania; Lin, Ken-Yu; Bellone, Marta; Todeschini, Paola; Silasi, Dan-Arin; Azodi, Masoud; Schwartz, Peter E.; Rutherford, Thomas J.; Carrara, Luisa; Tassi, Renata; Pecorelli, Sergio; Lockwood, Charles J.



Tissue factor expression in ovarian cancer: implications for immunotherapy with hI-con1, a factor VII-IgGF(c) chimeric protein targeting tissue factor.  


We evaluated the expression of tissue factor (TF) in ovarian cancer (EOC) and the potential of hI-con1, an antibody-like molecule targeting TF, as a novel form of therapy against chemotherapy-resistant ovarian disease. We studied the expression of TF in 88 EOC by immunohistochemistry (IHC) and real-time-PCR (qRT-PCR) and the levels of membrane-bound-complement-regulatory-proteins CD46, CD55 and CD59 in primary EOC cell lines by flow-cytometry. Sensitivity to hI-con1-dependent-cell-mediated-cytotoxicity (IDCC), complement-dependent-cell-cytotoxicity and inhibition of IDCC by ?-immunoglobulin were evaluated in 5-h (51)chromium-release-assays. Cytoplasmic and/or membrane TF expression was observed in 24 out of 25 (96%) of the EOC samples tested by IHC, but not in normal ovarian-tissue. EOC with clear cell histology significantly overexpress TF when compared to serous, endometrioid, or undifferentiated tumors by qRT-PCR. With a single exception, all primary EOC that overexpressed TF demonstrated high levels of CD46, CD55 and CD59 and regardless of their histology or resistance to chemotherapy, were highly sensitive to IDCC. The effect of complement and physiologic doses of ?-immunoglobulin on IDCC in ovarian cancer cell lines overexpressing TF was tumor specific and related to the overexpression of CD59 on tumor cells. Small-interfering-RNA-mediated knockdown of CD59 expression in ovarian tumors significantly increased hI-con1-mediated cytotoxic activity in vitro. Finally, low doses of interleukin-2 further increased the cytotoxic effect induced by hI-con1 (P < 0.01). hI-con1 molecule induces strong cytotoxicity against primary chemotherapy-resistant ovarian cancer cell lines overexpressing TF and may represent a novel therapeutic agent for the treatment of ovarian tumors refractory to standard treatment modalities. PMID:21725665

Cocco, Emiliano; Varughese, Joyce; Buza, Natalia; Bellone, Stefania; Lin, Ken-Yu; Bellone, Marta; Todeschini, Paola; Silasi, Dan-Arin; Azodi, Masoud; Schwartz, Peter E; Rutherford, Thomas J; Carrara, Luisa; Tassi, Renata; Pecorelli, Sergio; Lockwood, Charles J; Santin, Alessandro D



Virgin Caenorhabditis remanei females are attracted to a coital pheromone released by con-specific copulating males  

PubMed Central

The gonochoristic soil nematode Caenorhabditis remanei strictly requires copulation for species propagation. Males of this species are sexually promiscuous with females of other species; therefore, we asked in this study whether virgin C. remanei females display evidence of mate choice. We digitally recorded and measured the locomotor behaviors of one or more virgin females in the presence of a single male on a 5 mm diameter mating lawn. We observed that initially only the male modifies his locomotor trajectory to another animal on the mating lawn; the virgin females showed no locomotor bias toward the mate-searching male. However, once a male started to copulate, females in the vicinity altered their movement trajectories toward the copulating couple. Newly inseminated females are refractive to the coital signal, but partially regain their attraction to copulating males after 24 h. We found only copulating males with an intact gonad can attract females, and that the coital signal can be broadcasted at least 1.5 mm through the air. Unlike males, which are also attracted to hetero-specific females, virgin C. remanei females will only crawl toward a copulating con-specific male. We suggest that Caenorhabditis females use the coital signal as a pheromone to identify a vigorous male of their own species.

Markert, Mathew; Garcia, Luis Rene



Document-level classification of CT pulmonary angiography reports based on an extension of the ConText algorithm.  


In this paper we describe an application called peFinder for document-level classification of CT pulmonary angiography reports. peFinder is based on a generalized version of the ConText algorithm, a simple text processing algorithm for identifying features in clinical report documents. peFinder was used to answer questions about the disease state (pulmonary emboli present or absent), the certainty state of the diagnosis (uncertainty present or absent), the temporal state of an identified pulmonary embolus (acute or chronic), and the technical quality state of the exam (diagnostic or not diagnostic). Gold standard answers for each question were determined from the consensus classifications of three human annotators. peFinder results were compared to naive Bayes' classifiers using unigrams and bigrams. The sensitivities (and positive predictive values) for peFinder were 0.98(0.83), 0.86(0.96), 0.94(0.93), and 0.60(0.90) for disease state, quality state, certainty state, and temporal state respectively, compared to 0.68(0.77), 0.67(0.87), 0.62(0.82), and 0.04(0.25) for the naive Bayes' classifier using unigrams, and 0.75(0.79), 0.52(0.69), 0.59(0.84), and 0.04(0.25) for the naive Bayes' classifier using bigrams. PMID:21459155

Chapman, Brian E; Lee, Sean; Kang, Hyunseok Peter; Chapman, Wendy W



Status and Progress of a Fault Current Limiting Hts Cable to BE Installed in the con EDISON Grid  

NASA Astrophysics Data System (ADS)

In the last decade, significant advances in the performance of second generation (2G) high temperature superconducting wire have made it suitable for commercially viable applications such as electric power cables and fault current limiters. Currently, the U.S. Department of Homeland Security is co-funding the design, development and demonstration of an inherently fault current limiting HTS cable under the Hydra project with American Superconductor and Consolidated Edison. The cable will be approximately 300 m long and is being designed to carry 96 MVA at a distribution level voltage of 13.8 kV. The underground cable will be installed and energized in New York City. The project is led by American Superconductor teamed with Con Edison, Ultera (Southwire and nkt cables joint venture), and Air Liquide. This paper describes the general goals, design criteria, status and progress of the project. Fault current limiting has already been demonstrated in 3 m prototype cables, and test results on a 25 m three-phase cable will be presented. An overview of the concept of a fault current limiting cable and the system advantages of this unique type of cable will be described.

Maguire, J.; Folts, D.; Yuan, J.; Henderson, N.; Lindsay, D.; Knoll, D.; Rey, C.; Duckworth, R.; Gouge, M.; Wolff, Z.; Kurtz, S.



Virgin Caenorhabditis remanei females are attracted to a coital pheromone released by con-specific copulating males.  


The gonochoristic soil nematode Caenorhabditis remanei strictly requires copulation for species propagation. Males of this species are sexually promiscuous with females of other species; therefore, we asked in this study whether virgin C. remanei females display evidence of mate choice. We digitally recorded and measured the locomotor behaviors of one or more virgin females in the presence of a single male on a 5 mm diameter mating lawn. We observed that initially only the male modifies his locomotor trajectory to another animal on the mating lawn; the virgin females showed no locomotor bias toward the mate-searching male. However, once a male started to copulate, females in the vicinity altered their movement trajectories toward the copulating couple. Newly inseminated females are refractive to the coital signal, but partially regain their attraction to copulating males after 24 h. We found only copulating males with an intact gonad can attract females, and that the coital signal can be broadcasted at least 1.5 mm through the air. Unlike males, which are also attracted to hetero-specific females, virgin C. remanei females will only crawl toward a copulating con-specific male. We suggest that Caenorhabditis females use the coital signal as a pheromone to identify a vigorous male of their own species. PMID:24058874

Markert, Mathew; García, Luis René



Pro/con clinical debate: The use of prone positioning in the management of patients with acute respiratory distress syndrome  

PubMed Central

Critical care medicine is a relatively new specialty and as such there is not a great deal of accumulated data to allow clinicians to practice 'evidence-based medicine' in all situations they encounter. When evidence does exist, intensivists may choose not to follow it based on 'gut feelings' or their own interpretation of how the data apply to their patient. It is perhaps not surprising that these latter events occur given that intensivists are often literally fighting for their patient's lives. Prone positioning evokes a large emotional response from many intensivists. Despite accumulating data there appears to be two camps of clinicians: those who strongly believe in the therapy, and those who want more data. The emotion and rationale for the mindset of the two camps is evident in this issue of Critical Care Forum. With compelling arguments on both sides of the fence, it is apparent that this debate is far from over. The authors of this pro/con debate, which is based on a clinical scenario, first describe their position and then respond to their opponent's position.

Marini, John J; Rubenfeld, Gordon



Laboratory simulation of Kuiper belt object volatile ices under ionizing radiation: CO-N2 ices as a case study.  


The exposure of icy Kuiper belt objects (KBOs) by ionizing radiation was simulated in this case of exposing carbon monoxide-nitrogen (CO-N(2)) ices by energetic electrons. The radiation-induced chemical processing was monitored on-line and in situ via FTIR spectroscopy and quadrupole mass spectrometry. Besides the array of carbon oxides being reproduced as in neat irradiated carbon monoxide (CO) ices studied previously, the radiation exposure at 10 K resulted in the formation of nitrogen-bearing species of isocyanato radical (OCN), linear (l-NCN), nitric oxide (NO), nitrogen dioxide (NO(2)), plus diazirinone (N(2)CO). The infrared assignments of these species were further confirmed by isotopic shifts. The temporal evolution of individual species was found to fit in first-order reaction schemes, prepping up the underlying non-equilibrium chemistry on the formation of OCN, l-NCN, and NO radicals in particular. Also unique to the binary KBO model ices and viable for the future remote detection is diazirinone (N(2)CO) at 1860 cm(-1) (2?(5)) formed at lower radiation exposure. PMID:21687881

Kim, Y S; Zhang, F; Kaiser, R I



Trattamento ortopedico con corsetto  

Microsoft Academic Search

\\u000a Abstract  Conservative treatment of scoliosis by orthopaedic brace has an indication in cases of moderate or mild scoliosis. Its efficacy\\u000a is demonstrated through the experience of several orthopaedic schools. The indication to adopt an orthopaedic brace is given\\u000a by: curve degrees and its correggibility, skeletal age of patients and cosmetical aspect. The choice of the appropriate brace\\u000a depends on kind and

D. Peroni; F. Spreafico; W. Albisetti



urban ConAgraculture  

Microsoft Academic Search

Current pressures in today’s world caused me to investigate strategies of change in the organization of society to promote a more effi cient existence. Globalization, a movement characterized by the dissemination of economies, ethnicities, media, ideas, technologies, and production; has become today’s reality. The shift from imperialism to globalism has caused a decline in the power and importance of nation

Dale J Luebbert



The Protective Effect of Intrasplenic Transplantation of Ad-IL-18BP/IL-4 Gene-Modified Fetal Hepatocytes on ConA-Induced Hepatitis in Mice  

PubMed Central

Background Concanavalin A (ConA)-induced hepatitis is an experimental murine model mirroring the pathology of human autoimmune hepatitis. Aim To investigate the effects of intrasplenically transplanted fetal hepatocytes (BNL.CL2) transfected with recombinant adenovirus vector expressing the IL-18 binding protein (IL-18BP) and IL-4 fusion protein on ConA-induced hepatitis in mice. Methods Ad-IL-18BP/IL-4 was used to infect BNL.CL2 cells. IL-4 and IL-18BP fusion protein expression were detected by ELISA and Western blotting. BNL.CL2 cells infected with Ad-IL-18BP/IL-4 were intrasplenically transplanted into mice. After 10 days, mice were injected with ConA (15 mg/kg), and sacrificed 18 hours later. Liver injury was assessed by serum transaminase and liver histology. TNF-?, IL-18, IL-4, IL-10, IL-12p70 and monocyte-chemoattracting protein (MCP)-1 levels in serum and liver homogenates were detected by ELISA. Signaling molecules in liver homogenates were analyzed by Western blotting. Results Ad-IL-18BP/IL-4 effectively expressed the IL-18BP/IL-4 fusion protein for more than 14 days in BNL.CL12 cells. Treatment of mice with Ad-IL-18BP/IL-4-BNL.CL2 before ConA injection significantly reduced the elevated plasma levels of transaminases compared with ConA control groups. TNF-?, IL-18, IL-12p70 and MCP-1 levels in serum and liver homogenates from mice transplanted with Ad-IL-18BP/IL-4-BNL.CL2 were lower and IL-4 and IL-10 levels were higher than control groups. Phosphorylation levels of NF-?B p65, AKT, p38 and JNK1/2 in liver homogenates were markedly suppressed by Ad-IL-18BP/IL-4. Conclusions Ad-IL-18BP/IL-4 was effectively transfected into mouse BNL.CL2 cells. Intrasplenic transplantation of Ad-IL-18BP/IL-4-BNL.CL12 cells alleviated the severity of inflammation in ConA-induced experimental hepatitis and provides a useful basis for the targeted gene therapy of liver disease.

Xu, Chenhuai; Hong, Bo; Xu, Wanhong; Shen, Ling; Jin, Changzhong; Wu, Zhigang; Tong, Xiangmin; Yao, Hangping



Long-term fertility control in female cats with GonaCon™, a GnRH immunocontraceptive.  


The uncontrolled reproduction of free-roaming feral cats contributes to overpopulation and associated concerns regarding their welfare and impact on public health and the environment. Nonsurgical fertility control that could be administered to feral cats in the field would be a powerful tool for cat population control. The objective was to test the efficacy and duration of activity of a single-dose GnRH immunocontraceptive vaccine (GonaCon™) on the fertility of adult female laboratory cats. Vaccinated cats (n = 15) received a single injection of vaccine containing a GnRH-KLH conjugate (200 ?g) emulsified in a mycobacterial and oil adjuvant on study Day 0. Sham-treated cats (n = 5) received a single injection containing all vaccine components except the GnRH-KLH conjugate. A breeding trial started on study Day 120. Vaccinated cats had a longer time to conception (median 39.7 mo) compared to sham-treated cats (4.4 mo; P < 0.001). A total of 93% of vaccinated cats remained infertile for the first year following vaccination, whereas 73, 53, and 40% were infertile for 2, 3, and 4 y, respectively. At study termination (5 y after a single GnRH vaccine was administered), four cats (27%) remained infertile. The GnRH antibody titers declined more rapidly in short-term responding cats with < 2 y of infertility (n = 4), compared to long-term responding cats that experienced fertility control for >2 y (n = 11) (P < 0.05). Non-painful but persistent late-onset granulomatous injection site masses appeared 2 y after initial vaccination in five cats. We concluded that GnRH immunocontraception is an ideal candidate for further development for feral cat control. PMID:21835455

Levy, Julie K; Friary, John A; Miller, Lowell A; Tucker, Sylvia J; Fagerstone, Kathleen A



Preliminary experience with a 'sub-50' combined oral contraceptive, containing 35 micrograms ethinyl oestradiol and 1 mg norethisterone ('NeoCon').  


The present trend in oral contraception is clearly in favour of the 'sub-50' pills, taking into consideration the recent publications on the association between cardiovascular affections and pill intake. 'NeoCon', a combination pill containing 1 mg norethisterone and 35 micrograms ethinyl oestradiol, has been investigated in the United States, Mexico, Germany, Belgium and the United Kingdom. From all these studies, it could be concluded that it is an effective and well-tolerated oral contraceptive. From the present series, totalling 104 patients with 1232 cycles, first clinical impressions confirm the evaluations of other investigators: no pregnancies, only mild cycle disturbances disappearing after a few adaptation cycles, few side-effects and excellent tolerance. Due to the low potency and the low contents of its components, it is suggested that 'NeoCon' is appropriate for all women in general and for the younger women in particular. PMID:7433480

Schellen, A M



Canadian Shield brine from the Con Mine, Yellowknife, NT, Canada: Noble gas evidence for an evaporated Palaeozoic seawater origin mixed with glacial meltwater and Holocene recharge  

Microsoft Academic Search

Dissolved noble gas concentrations were measured in high salinity (270g\\/L) Ca(Na)-Cl groundwaters from the Con Mine, Yellowknife, Canada in an effort to discriminate between two possible origins, as either a brine generated by evaporative enrichment in a Paleozoic inland sea, or marine water concentrated by freezing during glacial times. Major ion and isotope geochemistry indicate that brines from the deepest

Shane Greene; Nick Battye; Ian Clark; Tom Kotzer; Dennis Bottomley



An appraisal of a column-generation-based algorithm for a centralized train-con?ict resolution on metropolitan railway network  

Microsoft Academic Search

In practice, a train-con?ict resolution is decentralized around the dispatchers each of whom, with her rule-of-thumb to operational data, controls a few segments from a global railway network. Conceptually, a global sub-optimality or infeasibility of the decentralized system is resolved by a network controller on the top of the lower layers of the dispatchers and the drivers operating trains on

Sung-Pil Hong; Yun-Hong Min; Soon-Heum Hong


Dissection of the Intracellular Pathways in Hepatocytes Suggests a Role for Jun Kinase and IFN Regulatory Factor1 in Con A-Induced Liver Failure1  

Microsoft Academic Search

Con A administration results in dose-dependent immune-mediated liver injury. Cytokines are important to determine the outcome of liver failure in this model, and especially TNF-a and IFN-g directly contribute to hepatocyte damage. The intracellular pathways of these two cytokines, which eventually result in tissue destruction, are not well defined. Here we used anti-IFN-g Abs and adenoviral vectors that express molecules

Konrad Streetz; Bastian Fregien; Jorg Plumpe; Kerstin Korber; Stefan Kubicka; Stephan C. Bischoff; Michael P. Manns; Gisa Tiegs; Christian Trautwein


A review of the practice of sedation with inhalational anaesthetics in the intensive care unit with the AnaConDa(®) device.  


The intensive care unit (ICU) environment is often perceived to be hostile and frightening by patients due to unfamiliar surroundings coupled with presence of numerous personnel, monitors and other equipments as well as a loss of perception of time. Mechanical ventilation and multiple painful procedures that often need to be carried out in these critically ill patients add to their overall anxiety. Sedation is therefore required not only to allay the stress and anxiety, but also to allow for mechanical ventilation and other invasive therapeutic and diagnostic procedures to be performed. The conventional intravenous sedative agents used in ICUs suffer from problems of over sedation, tachyphylaxis, drug accumulation, organ specific elimination and often lead to patient agitation on withdrawal. All this tend to prolong the ventilatory as well as ICU and hospital discharge time, which increase the risk for infection and add to the overall increase in morbidity, mortality and hospital costs. In 2005, the anaesthetic conserving device (AnaConDa(®)) was marketed for ICU sedation with volatile anaesthetic agents. A number of trials have shown the effectiveness of using volatile anaesthetic agents for ICU sedation with the AnaConDa device. Compared with intravenous sedatives, use of volatile anaesthetic agents have resulted in shorter wake up and extubation time, lesser duration of mechanical ventilation and faster discharge from hospitals. This review shall focus on the benefits, technical pre-requisites and status of sedation with volatile anaesthetic agents in ICUs with the AnaConDa(®) device. PMID:23325934

Misra, Satyajeet; Koshy, Thomas



Pro/Con Forum: The MACOS Controversy. The Push for a Uniform National Curriculum [And] MACOS Revisited: A Commentary on the Most Frequently Asked Questions about "Man: A Course of Study"  

ERIC Educational Resources Information Center

|The pro/con forum presents opposing viewpoints on the controversial MACOS curriculum (Educational Development Corporation) by Peter Dow, Director of EDC and Congressman John B. Conlan, Arizona. (JR)|

Conlan, John B.; Dow, Peter B.



Theoretical Study of Magnetic Properties of VN, CrN, MnN, FeN and CoN under strain  

NASA Astrophysics Data System (ADS)

We present an ab initio tooled study on magnetic and electronic properties of 3d transition metals mononitrides under hydrostatic and biaxial strain, in wurtzite (w) and zincblende (zb) structure, and find all of them to become half-metallic (HM) under lattice expansion in the zb structure. The first compound to become HM under lattice expansion is MnN, followed by CrN, VN, FeN and CoN, with integer magnetic moments of 4, 3, 2, 5 and 6 ?B, respectively. We investigate the possibility of MBE growing of zb-CrN on cubic GaN.

Ribeiro, M.; Marques, M.; Scolfaro, L. M. R.; Teles, L. K.; Ferreira, L. G.



Primary and Secondary T-cell Lymphomas of the Breast: Clinico-pathologic Features of 11 Cases  

PubMed Central

Breast involvement by non-Hodgkin lymphomas is rare, and exceptional for T-cell lymphomas; we studied the morphologic, immunophenotypic, and clinical features of 11 patients with T-cell non-Hodgkin lymphomas involving the breast. Four cases fulfilled the definition criteria for primary breast lymphomas, 3 females and 1 male, with a median age of 51 years. One primary breast lymphomas was T-cell lymphoma unspecified, other was subcutaneous panniculitis-like T-cell lymphoma, and 2 cases were anaplastic large cell lymphomas. One of the anaplastic large cell lymphoma cases was found surrounding a silicone breast implant and presented as clinically as mastitis; whereas the other case occurred in a man. T-cell lymphoma secondarily involved the breast in 7 patients, all women and 1 bilateral, with a median age of 29 years. These secondary breast lymphomas occurred as part of widespread nodal or leukemic disease. Three patients had adult T-cell leukemia/lymphoma, including the patient with bilateral lesions, 3 others had precursor T-lymphoblastic lymphoma/leukemia, and the other presented with a peripheral-T-cell lymphoma nonotherwise specified type. Breast T-cell lymphomas are very infrequent and are morphologically and clinically heterogeneous.

Gualco, Gabriela; Chioato, Lucimara; Harrington, William J.; Weiss, Lawrence M.; Bacchi, Carlos E.



Respiratory epithelial adenomatoid hamartoma of the maxillary sinus: case report Amartoma adenomatoide epiteliale respiratorio del seno mascellare: caso clinico  

Microsoft Academic Search

Parole chiave Seno mascellareNeoplasie dei seni paranasaliSinusiti cronicheTerapia chirurgicaAmartoma adenomatoide epiteliale Summary The case is described of a male patient with respiratory epithe- lial adenomatoid hamartoma of the left maxillary sinus that ini- tially presented as a chronic sinus inflammation. This benign lesion is characterized by glandular proliferation originating from the surface of the respiratory epithelium. Maxillary sinus localisation is



Tireoidite auto-imune bociogenica. Aspectos do diagnostico clinico e laboratorial. (Autoimmune thyroiditis goitrogenic. Aspects of clinical and laboratorial diagnosis).  

National Technical Information Service (NTIS)

To asses the accuracy achieved by the A.C.A.T. and other clinical and laboratorial criterion in the diagnoses of T.A.I.B. we investigated twenty patients with goiter and antimicrossomal antibodies titres of 1/1.600 or more. Analysing the parameters useful...

H. F. Z. Costa



Limits of Fine-Needle Aspiration Cytology in Diagnosing Pilomatrixoma: A Series of 25 Cases with Clinico-Pathologic Correlations  

PubMed Central

Background: Pilomatrixoma (PMX) is a benign, quite uncommon, skin neoplasm, which is frequently misdiagnosed by clinicians. Aim: We have analyzed 25 PMX to determine the agreement between clinical diagnosis, preoperative FNA characteristics, and corresponding histopathological specimens; moreover, reliable cytologic criteria for PMX and the differential diagnosis to avoid cytological pitfalls have been emphasized. Materials and Methods: By fine-needle aspiration (FNA) cytology a series of consecutive cases of PMX collected during last 5 years were studied. Smears were stained by Papanicolau and May-Grünwald-Giemsa. Results: Patients affected by PMX were 11 males, 14 females (ratio 1:1.27); the mean age was 32.72 years with age range 3-78 years, being 72% (18/25) of patients 40 years or less. PMX was mainly distributed in the head-neck region (52%), scalp (16%), upper/lower arms (28%), and chest (4%). The observed diagnostic cytological features were represented by clusters of basaloid epithelial cells, shadow or ghost cells, inflammatory background, calcification, and giant cells. Unfortunately, not all these morphological aspects were always disclosed in smears, thus making the cytological preoperative diagnosis questionable and problematic. Conclusions: The experience of a well-trained cytopathologist should distinguish the relevant FNA features in terms of smear background, architecture, and cell morphology. The most dangerous mistake in FNA diagnosis of PMX regards a diagnosis of primary malignant or metastatic cutaneous lesions.

Ieni, A; Todaro, P; Bonanno, A M; Catalano, F; Catalano, A; Tuccari, Giovanni



A French national survey on infiltrating breast cancer: analysis of clinico-pathological features and treatment modalities in 1159 patients  

Microsoft Academic Search

Background  Despite the approximate 42,000 yearly new cases of breast cancer in France, there have been very few exhaustive studies on\\u000a the clinicopathological features and treatment options of this disease.\\u000a \\u000a \\u000a \\u000a Methods  Thus, a prospective, non-selective, nationwide survey on infiltrating breast cancer (IBC) was conducted in France from September\\u000a 2001 to April 2002, in order to assess the epidemiological features of newly diagnosed

Bruno Cutuli; Paul Henri Cottu; Jean Paul Guastalla; Hubert Mechin; Anne Costa; Rosemary Jourdan



[Pharmacological and clinico-pharmacological studies of a combination preparation for calves having antianemia and general tonic action].  


A combined preparation, biofer, was studied, defining its clinical and pharmacological capacity. Featuring in its composition are: normal bovine gammaglobulin, 8.0 g; ferridextran (dextrofer-100), 32 cm2 (= 3.2 g Fe); cuprum sulfuricum, 0.32 g (= 0.08 Cu); Co chloride, 0.18 g (= 0.08 Co); cyancobalamin, 0.0032 g; and protein hydrolysate up to 100 cm3, at pH = 7.0-7.2. The local and total tolerance of animals for biofer was studied along with the acute toxicity, absorption, and retention in the body of test animals and calves as well as the antianemic action in albino mice and calves. It was found that at 4 degrees C to 8 degrees C the shelf life of biofer was 2 years. Its LD50 at subcutaneous injection to albino rats was 11.7 cm3/kg body mass. At the rate of 0.6 cm3/kg (i/m) rabbits did not manifest local and total intolerance; at 1.8 cm3/kg there was no local inflammation, however, a transient drop of appetite was seen; at 3 cm3/kg rabbits manifested intoxication with exitus. At i/m introduction to rabbits and calves biofer was more slowly absorbed than dextrofer-100. The liver and spleen of animals injected with biofer showed higher values for copper. In i/m application to anemic albino rats biofer showed a better antianemic effect than dextrofer-100. In calves it activated to a better extent both erythropoiesis and leukopoiesis. PMID:6197805

Dilov, P; Antonov, S; Boiadzhieva, A; Iotov, M



Mucinous colorectal adenocarcinoma: influence of mucin expression (Muc1, 2 and 5) on clinico-pathological features and prognosis  

Microsoft Academic Search

Background  Mucinous component is associated with distinct clinical and pathological features and poor survival in colorectal cancer.\\u000a The purpose of this study was to determine differences in outcomes of patients with mucinous colorectal adenocarcinoma according\\u000a to the type of mucin expressed.\\u000a \\u000a \\u000a \\u000a Materials and Methods  Immunohistochemistry was performed in all tumors of patients who underwent radical surgery between 1998 and 2003 with mucinous

Rodrigo Oliva Perez; Bárbara Helou Bresciani; Cláudio Bresciani; Igor Proscurshim; Desiderio Kiss; Joaquim Gama-Rodrigues; Diego Daniel Pereira; Viviane Rawet; Ivan Cecconnello; Angelita Habr-Gama



Alteracoes osseas uremicas - Estudo clinico laboratorial, cintigrafico e radiologico. (Uremic bone diseases - Clinical laboratory, scintigraphic and radiological study).  

National Technical Information Service (NTIS)

This paper evaluated the uremic bone disease in 10 patients on peritoneal dialysis, 10 on hemodialysis and 10 submited to renal transplantation. According to biochemical evaluation we observed hypocalcemia in some patients on dialysis and hipercalcemia in...

W. C. F. Silva



Audit Clinico Su Indicatori Qualita in Radioterapia Selezionati per Patologie (Clinical Audit on Evaluation Indicators in Radiotherapy for Different Pathologies).  

National Technical Information Service (NTIS)

In the framework of the Istituto Superiore di Sanita (the Italian National Institute of Health) project of evaluation indicators in radiotherapy one of the working groups, in which 30 radiotherapy centres together with their health physics units were repr...



Myofibrillar (desmin-related) myopathy: clinico-pathological spectrum in 3 cases and review of the literature.  


Myofibrillar or desmin-related myopathies encompass neuromuscular disorders with abnormal deposits of desmin and myofibrillar alterations. We report 3 unrelated patients presenting with proximal and distal myopathy, and, as a unique congenital syndrome, diffusely distributed myopathy, osteoporosis and myopia. Muscle biopsies shared cytoplasmic inclusions, rimmed vacuoles, and ragged-red-like fibers. Sarcoplasmic inclusions, either plaque-like or amorphous, strongly immunoreacted on dystrophin and variably for desmin, alphaB crystallin and ubiquitin. Cyclin-dependent kinases CDK1, CDK2 and CDK5 were overexpressed in affected fibers. Ultrastructurally, focal myofibrillar disruption was accompanied by tubulo-filamentous inclusions in one case and abundant glycogen and enlarged mitochondria displaying respiratory chain dysfunction at biochemistry in another case. Molecular analysis of the alphaB crystallin gene coding sequence and exons 4, 5 and 6 of the desmin gene did not reveal any mutation. The morphologic denominator of hyaline structures and areas of myofibrillar destruction occurs in heterogeneous conditions and may overlap with features of inclusion body myopathy and mitochondrial myopathy. PMID:12365725

Wanschit, J; Nakano, S; Goudeau, B; Ströbel, T; Rinner, W; Wimmer, G; Resch, H; Jaksch, M; Akiguchi, I; Vicart, P; Budka, H


A comparative study of the clinico-aetiological profile of hyponatremia at presentation with that developing in the hospital  

PubMed Central

Background & objectives: Hyponatremia is a common problem encountered in patients presenting with nonspecific symptoms. We undertook this study to investigate the clinical profile of patients with hyponatremia, the precipitating factors, the response to therapy and to compare, using these parameters, hyponatremia at presentation to that developing in the hospital. Methods: Seventy consecutive patients with serum sodium less than or equal to 125 mmol/l at presentation or at any time during hospital admission were identified and studied using a proforma. The severity of hyponatremia, therapy given and time taken for recovery were analysed. Results: The mean age of patients was 48.1 ± 16.1 yr. The mean serum sodium was 117.8 ± 6.4 mmol/l. Confusion, headache and malaise were the most common symptoms, two patients had seizures, and 20.0 per cent patients showed no clinical manifestations. Nausea was significantly (P<0.05) more common in patients presenting with hyponatremia. 22 patients (31.4%) developed hyponatremia during their stay in the hospital. 3 patients (4.3%) presented with hyponatremia which got worse during the admission period. Most had multiple precipitating factors, decreased intake being the most common (82.9%), followed by increased losses (65.7%) and miscellaneous factors (70.0%). Drugs, fluid overload and inappropriate Ryle's tube feeds more commonly precipitated hyponatremia in in-hospital patients. Time taken for recovery showed negative correlation with the serum sodium. Patients with in-hospital hyponatremia took significantly longer time to recover (P<0.05). Interpretation & conclusions: Decreased intake was found to be the commonest cause of hyponatremia, thus, ensuring adequate oral intake, especially in patients on liquid diet and in manual labourers, and correction of hyponatremia as soon as an abnormality is detected is important.

Agarwal, S. Mahavir; Agrawal, Aparna



Implantacion de programas de telemedicina en la sanidad publica de Espana: experiencia desde la perspectiva de clinicos y decisores  

Microsoft Academic Search

Objective: To identify the main benefits and risks related to the implementation of telemedicine programs in Spain, based on the experience of the actors influencing the decision-making process. Participants and methods: We performed a qualitative study based on audiotaped semi-structured telephone interviews. Eleven interviews were carried out, and the perspective of four physicians, three administrators, two researchers and two telecommunications

Vinita Mahtani Chugani; Roberto Luis; Martin Fernandez; Enrique Soto Pedre; Virginia Yanes Lopez; Pedro Serrano Aguilar


Non-familial olivopontocerebellar atrophy combined with late onset Alzheimer's disease: a clinico-pathological case report  

Microsoft Academic Search

A 76-year-old woman with olivopontocerebellar atrophy (OPCA) presented with progressive intellectual deterioration. She showed cerebellar ataxia and muscle atrophy and weakness, and gradually developed generalized dementia with visuospatial disturbance. An autopsy revealed numerous senile plaques (SPs), neurofibrillary tangles (NFTs) and neuropil threads particularly in the CA1, subiculum and entorhinal cortex and to a lesser degree in the cerebral neocortex shown

Katsuji Kobayashi; Yuken Fukutani; Masahiro Hayashi; Kenji Miyazu; Fumihiko Muramori; Tatsuyuki Aoki; Masami Mukai; Kazuo Sasaki; Kiminori Isaki; Yoshifumi Koshino



Coexpression of CDX2 and MUC2 in gastric carcinomas: Correlations with clinico-pathological parameters and prognosis  

Microsoft Academic Search

Abstract Abstract Abstract Abstract Abstract AIM: Toevaluate the role of CDX2 homeobox,protein as a predictor for cancer progression,and prognosis as well as its correlation with MUC2 expression. CDX2 represents a transcription factor for various intestinal genes (including MUC2) and thus an important,regulator,of intestinal differentiation, which could previously be identified in gastric carcinomas,and intestinal metaplasia. METHODS: Formalin-fixed and paraffin-embedded tissues

Kristina Roessler; Stefan P. Mönig; Paul M. Schneider; Franz-Georg Hanisch; Stephanie Landsberg; Juergen Thiele; Arnulf H. Hölscher; Hans P. Dienes; Stephan E. Baldus



Enzymatic evaluation of gingival crevicular fluid in cleft palate patients during orthodontic treatment: A clinico-biochemical study  

PubMed Central

Background: Therapeutic goal in patients with cleft lip and palate is esthetics and long-term health of the stomatognathic system. Patients with cleft lip and palate routinely require extensive and prolonged orthodontic treatment. The osseous structures are absent or poorly developed in the osseous clefts and may be traumatized in the course of orthodontic therapy; hence require constant monitoring during orthodontic treatment. The aim of the study was to evaluate the tissue response of cleft palate patients by quantitative analysis of enzyme activity during orthodontic treatment and assess any difference in the tissue response with that of noncleft patients undergoing orthodontic treatment. Materials and Methods: 20 patients requiring orthodontic treatment agedbetween 15 to 25 years were included to participate in the studyof which ten were cleft palate patients (group I) and ten noncleft patients (group II). The GCF samples were collected at incisor and molar sites during orthodontic treatment on days as per the study design in both the groups. The GCF enzymatic levels were estimated and compared. Results: Both groups showed significant increased enzyme activity at the incisor site compared to molar site corresponding to the phases of tooth movement. Conclusion: There was significant difference in enzyme activity between the incisor adjacent to the cleft site and molar site. There was no difference in the tissue response between cleft palate patients and noncleft patients during orthodontic treatment.

Kulal, Rithesh; Thomas, Biju; Ravi, M. S.; Shetty, Suchetha



Clinico-Pathological Discrepancies in the Diagnosis of Causes of Maternal Death in Sub-Saharan Africa: Retrospective Analysis  

Microsoft Academic Search

BackgroundMaternal mortality is a major public-health problem in developing countries. Extreme differences in maternal mortality rates between developed and developing countries indicate that most of these deaths are preventable. Most information on the causes of maternal death in these areas is based on clinical records and verbal autopsies. Clinical diagnostic errors may play a significant role in this problem and

Jaume Ordi; Mamudo R. Ismail; Carla Carrilho; Cleofé Romagosa; Nafissa Osman; Fernanda Machungo; Josep A. Bombí; Juan Balasch; Pedro L. Alonso; Clara Menéndez



First case report of anaphylaxis caused by Rajgira seed flour (Amaranthus paniculatus) from India: a clinico-immunologic evaluation.  


The prevalence of food allergy is reported to be 3-4% in adults and about 6% in children. However food allergy across different countries accounts for 35-50 % all cases of anaphylaxis to foods. In the present study, we have reported a case of anaphylaxis to Amaranth grain (Amaranthus paniculatus) commonly known as Rajgira (Ramdana) in India. A 60 year old female suffered anaphylaxis after consuming Rajgira seed flour generally consumed during fasting. Food allergy to Amaranth seeds is not reported so far. The patient reported to hospital with complaints of itching in mouth, choking throat, redness and swelling of face and burning abdomen within 5 min of consuming Rajgira flour. Clinical and immunological investigations revealed SPT and oral challenge positivity beside high allergen specific IgE in the serum of the patient. Three IgE binding protein fractions were detected in roasted Rajgira seed flour extract which could be considered to be allergenically important for triggering anaphylaxis. PMID:23517398

Kasera, Ramkrashan; Niphadkar, P V; Saran, Aditya; Mathur, Chandni; Singh, A B



[The clinico-hematological indices of the participants in the cleanup of the aftermath of the Chernobyl accident].  


Clinicohematological investigations and cytogenetic analysis of blood lymphocytes were made 5-7 years after the Chernobyl accident in 201 liquidators who had worked in the radionuclide-contaminated zone. Among the somatic diseases found in the examinees statistically more prevalent were cardiovascular and gastrointestinal affections, asthenic syndrome, thyroid disorders. Hemograms presented a rise in hemoglobin, red cell and eosinophil content, a drop in the number of neutrophils. A tendency to erythrocytosis was observed in 20.3% of the wreckers. Dicenters and rings were abundant in the lymphocytes of 69% of the cytogenetically examined examinees 5-7 years after the exposure to radiation. PMID:8928077

Pivnik, A V; Moiseeva, T N; Domracheva, E V; al-Radi, L S; Broun, G A; Karpova, I V; Kremenetskaia, A M; Maslova, E R; Shklovski?-Kordi, N E; Vorob'ev, A I



[Clinico-statistical considerations on the agreement between echographic and biopsy findings in hepatopathies of the diffuse type].  


A comparison between echographic and bioptic findings in diffuse liver disease is reported. The data obtained are compared with those quoted in the literature and found to be very similar. Finally echography is identified as the indispensable examination of choice. PMID:3523300

Cusumano, S; De Mori, E; Buschini, M; Carugati, A; Farina, F



Clinico-pathological, histochemical and therapeutic studies on concurrent sarcoptic and notoedric acariosis in rabbits (Oryctolagus cuniculus)  

Microsoft Academic Search

Concurrent acariosis due to sarcoptes scabiei var cuniculi (sarcoptes scabiei ) and notoedres cati var cuniculi (notoedres cuniculi ) was observed in Angora and New Zealand white rabbits belonging to the University rabbitry at Srinagar in Jammu and Kashmir (India). Clinically, the affected rabbits revealed scales, lichenification, scab formation, alopecia and pruritis initially on the face near the upper lip

Mohammed Maqbool Darzi; Masood Saleem Mir; Rafiq Ahmed Shahardar; Basharat Ahmed Pandit


Clinico-epidemiological profile of burn patients admitted in a tertiary care hospital in coastal South India.  


Every year a substantial proportion of deaths in India occur due to burn injuries. Prolonged morbidity as well as temporary and permanent disability due to burns results in a heavy economic loss. The etiological factors of burn injuries vary considerably in different communities and regions and hence the need for detailed epidemiological studies to understand the problem status in different regions. This study was aimed to study the sociodemographic profile of burn patients and to evaluate the causes, manner, and place of occurrence of burns injuries along with its outcome. A registry-based retrospective study was conducted at a tertiary care hospital in coastal South India, and the medical records of all the patients admitted to the burns centre during the year 2009 were reviewed. The data were analyzed using SPSS version 11.5. A total of 101 burn patients were admitted during the study period. The burn patients were aged between 4 months and 80 years with a mean age of 32.11 (± 3.46) years. The overall male to female ratio was 0.83:1. Majority of the patients were Hindus and were married. Flame burns were the most common etiology for sustaining burns (82.2%). Most of the burn injuries were sustained at home (n = 81, 80.2%), and the manner was designated as accidental in 79.2% of the cases. The TBSA involvement in burns ranged from 5 to 100% and the mean TBSA was found to be 45.8 ± 24.7%. A higher TBSA involvement is associated with an increased risk of mortality and this association between TBSA and mortality was found to be statistically significant (P < .05). Mortality rate in our study was 40.9%. Septicemia (n = 24, 63.2%) was the most common cause of death followed by shock (n = 12, 31.6%). Higher mortality is found to be associated with female sex, suicides, and flame burns. This study identifies the epidemiological and clinical features associated with burn injuries in coastal South India. Majority of the burn victims in our study were married females of younger age group. Although the manner of sustaining burns was mostly accidental, females were proportionately more commonly the victims of suicides and homicides than males. Injuries and deaths due to burns are preventable, provided a community-specific preventive program is implemented with a strong educational component. PMID:22964550

Kumar, Nithin; Kanchan, Tanuj; Unnikrishnan, B; Rekha, T; Mithra, Prasanna; Venugopal, Anand; Sundar, Sachin; Raha, Shreya


[Morphologic placenta findings in clinico-serologically verified and suspected rubella infection in the 2d half of pregnancy].  


Rubeola is the congenital infection with the highest rate of embryonal damage. The hematogenous transplacental way of infection also causes morphological changes at the vessels of the placental villi. We examined 38 placentas from up to the 44th week of gestation and the fetus and children belonging to them. We regarded the clinical and serological findings. 6 out of 16 placentas from up to the 18th week of gestation (37.5%) showed endangitis obliterans. Two cases showed changes of the lenses. (Group I). In 10 out of 12 cases from the 19th to the 36th week of gestation (Group II) we found morphological changes in the vessels of the placental villi. The children belonging to them showed nonspecific malformations. From the 37th week of gestation (Group III) half of the placentas was histologically conspicuous. The children did not show malformations specific for rubeola. We refer to the possibilities and limitations of performing light microscopic diagnosis in placenta when there is the suspicion of rubeola infection, intrauterine death of the fetus and postnatal delay of the child's development. PMID:1299081

Horn, L C; Becker, V


Sexually transmitted diseases and sexual lifestyles of long-distance truck drivers: a clinico-epidemiologic study in south India.  


Our study objective was to determine the prevalence and pattern of sexually transmitted diseases (STDs) and to study sexual lifestyles of long-distance truck drivers and their assistants in south India. For this, a total of 263 truck drivers/assistants were recruited from the highway clinic from October 1999 to March 2001. All of them were sexually active and heterosexual contact was the predominant mode (99.2%). Two-thirds of them had contact with commercial sex workers (CSWs) and roughly 60% admitted alcohol consumption. One hundred and two participants (38.7%) had various STDs. The positivity rates of HIV, VDRL and HBsAg were 15.9%, 13.3% and 21.2% respectively. The higher median age, education less than primary school level, longer duration of occupation, longer duration of each trip and a previous history of genital ulcer disease were significant risk factors for the acquisition of HIV infection. PMID:12230925

Manjunath, J V; Thappa, D M; Jaisankar, T J



A clinico-dermoscopic approach for skin cancer screening: recommendations involving a survey of the international dermoscopy society.  


Dermoscopy is useful for skin cancer screening, but a detailed approach is required that integrates this tool into a rational clinical work flow. To investigate clinician perceptions and behavior in approaching patients with skin tumors, a survey was launched by electronic mail through the International Dermoscopy Society. After 4 months, the responses were analyzed and significant findings calculated. Considering the current approach of study participants in examining patients for skin cancer, an up-to-date system of triage is presented in this review, which aims to promote an improved diagnostic accuracy and more timely management of skin malignancy. PMID:24075542

Argenziano, Giuseppe; Giacomel, Jason; Zalaudek, Iris; Blum, Andreas; Braun, Ralph P; Cabo, Horacio; Halpern, Allan; Hofmann-Wellenhof, Rainer; Malvehy, Josep; Marghoob, Ashfaq A; Menzies, Scott; Moscarella, Elvira; Pellacani, Giovanni; Puig, Susana; Rabinovitz, Harold; Saida, Toshiaki; Seidenari, Stefania; Soyer, H Peter; Stolz, Wilhelm; Thomas, Luc; Kittler, Harald



[Vegetarian diet in treating elderly patients with ischemic heart disease (clinico-hemodynamic, biochemical, and hemorheological effects)].  


The inclusion of balanced antiatherogenis of vegetarian diet in a complex of therapeutical means of the patients of ischemic heart disease in elderly age (average age 72.3 years) promotes normalization of clinical and biochemical parameters, correction of lipid metabolism and parameters plasma hemostasis. Vegetarian antiatherogenis the diet is perspective means in treatment of the patients ischemic heart disease of elderly age. PMID:12227010

Ivanov, A N; Medkova, I L; Mosiagina, L I



[SAPHO syndrome: clinico-rheumatologic and radiologic differentiation and classification of a patient sample of 86 cases].  


Synovitis (inflammatory arthritis), acne (pustulosa), pustulosis (psoriasis, palmoplantar pustulosis), hyperostosis (acquired), and ostitis (bland osteomyelitis) are symptoms forming the acronym SAPHO, which is a syndrome of nosologic heterogeneity. All entities forming the SAPHO syndrome are connected by a non-obligate dermatoskeletal association with an aseptic pustulous character. 86 cases were analyzed clinically, radiologically and by histology/histopathology. 31 adult patients showed the typical triad of pustulosis palmo-plantaris (psoriatica, PPP), sterno-costo-clavicular hyperostosis (SCCH), and "productive" spondylopathy, which we define as entity I. spondarthritis hyperostotica pustulopsoriatica (Spond.hyp.pp). Twelve adolescent and 13 adult patients showed entity no. II: chronic recurrent multifocal osteomyelitis (CRMO), being characterized by non-purulent osteomyelitis of plasma-cell sclerotic type, potentially being a reactive inflammatory process. 50% of the adult patients with CRMO showed PPP. Differentiation between these two entities is possible by detection of ossifying enthesiopathy in cases of Spond. hyp.pp and primarily chronic osteomyelitis in cases of CRMO. Two more entities or abortive forms of group I and II are III: the inflammatory syndrome of the anterior chest-wall (ACW syndrome) and IV: the more productive form of isolated sterno-costoclavicular hyperostosis (SCCH). Both are connected quite frequently to HLA-B-27-independent forms of spondarthritis and to pustulous dermatosis. More rarely we find osteo-articular symptoms in cases of acne pustulosa, which form group V: acne-associated spondarthritis and CRMO in the case of acne. Adult forms of CRMO with different forms of appearance (lumosacro-iliac hyperostosis with retroperitobeal fibrosis, pelvic type with affection of the hip-joint) are described. The immunologic theory of a "reactive osteomyelitis" potentially triggered by saprophytes is described. The inverse acne triad is brought in a context of skin symptoms. A case of intercurrent postpartum symptoms together with ulcerative colitis is described. Three cases of patients with Crohn's disease are described. Clinical features, radiological findings, and histopathological elements are brought together to determine the connections between the different entities and the possibilities of differentiation. With these elements together with bone-scan, it is often not necessary to obtain a bone specimen. Therapeutical possibilities, especially concerning CRMO, are discussed. "SAPHO syndrome" is more a sign-post on the way to a more subtle diagnosis when it comes to hyperostotic, skin-associated diseases, and it needs interdisciplinary work to clear the situation. PMID:10769419

Schilling, F; KesslerS



Predictive value of PCA3 in urinary sediments in determining clinico-pathological characteristics of prostate cancer  

Microsoft Academic Search

PURPOSE: PCA3 urine tests have shown to improve the specificity in prostate cancer (PCa) diagnosis, and have thus the potential to reduce the number of unnecessary prostate biopsies and to predict repeat biopsy outcomes. In this study, PCA3 was correlated with clinical stage, biopsy Gleason score (GS), radical prostatectomy GS, tumor volume, and pathological stage to assess its potential as

Daphne Hessels; Martijn P. M. Q. van Gils; Onno van Hooij; Sander A. Jannink; J. Alfred Witjes; Gerald W. Verhaegh; Jack A. Schalken




Microsoft Academic Search

SUMMARY The Authors present a report on their clinical experience in one case of reconstruction of one finger of the hand with a perforant interdigital flap of the foot. This flap is a variant of the dorsal first web space skin flap; it may be used to cover deficits of the hand up to 2.5\\/3 cm long, because of its



[Clinico-immunologic monitoring of HIV-infected patients: comparative analysis of indicators, characterizing development of the disease].  


The paper contains the results of a 15-year monitoring (since 1986 to 2001) of HIV-infected patients followed up at the clinic of the Institute of Immunology, Federal Department "Medbioextrem", Russia's Health Ministry. An analysis of a category of HIV-infected persons, who practiced the intravenous consumption of drugs since 1997 to 2001, revealed not only concomitant multi-virus infections (hepatitis C--68%, hepatitis B--48%, herpes 41%, fungal infections--66% and bacterial infections--46%) but also lesions (up to 70%) in the gastrointestinal tract and in the hepatic-cellular and hepatic-biliary systems. It was established that, when only immunological indices are taken account of in presence of multi-virus infections, it does not ensure an adequate evaluation of an HIV-patient condition. The below biochemical parameters must be necessarily taken into consideration: activity of alanine aminotransferase, aspartate aminotransferase and of alkaline phosphatase. The changes in the biochemical parameters were shown to be essentially higher in HIV patients with hepatitis C virus (HCV) even during the 2 initial follow-up years, when the immunological parameters are in the norm or even insignificantly below it. A comparative analysis of dynamic clinical, immunological and biochemical indices was made within the case study for the purpose of defining the prognostic criteria for HIV progression scenarios. PMID:14708227

Papuashvili, M N; Shchelkanov, M Iu


Estudio de la fotoabsorción y fotoionización de la molécula de alta relevancia atmosférica no a través de los estados Rydberg con la metodología MQDO  

NASA Astrophysics Data System (ADS)

Los procesos de fotoionización son de una importancia fundamental [1] y encuentran aplicación en un gran número de contextos científicos: Astrofísica [2], química de las radiaciones, biología. Los investigadores de dichos campos, necesitan de valores de fiables de secciones eficaces para la fotoionización parcial, la Fotoabsorción, así como para los procesos de fotofragmentación en amplios intervalos espectrales, particularmente en estudios de modelización [3-5]. En este trabajo se ha centrado la atención sobre el oxido nítrico, que se ha considerado apropiado y relevante por varios motivos: por el trascendental papel que representa en la física y química de la alta atmosfera [6], aparte de por estar íntimamente relacionado con los problemas de contaminación. Los procesos de recombinación disociativa [7] del NO, donde los estados Rydberg se encuentran directamente implicados, son relevantes, por ejemplo, en las regiones E y F de la ionosfera [7]. En este trabajo se estudia la fotoionización del NO desde el estado fundamental con la versión molecular del método del orbital de defecto cuántico (MQDO). Para ello se calcula el diferencial de las fuerzas de oscilador parciales que constituyen los canales de fotoionización del NO desde el estado fundamental. La continuidad del diferencial de fuerza de oscilador calculada a través del umbral de fotoionización, esto es, en las regiones del espectro discreta y del continua, se adopta como criterio de calidad la escasez de datos comparativos [8].

Bustos, E.; Velasco, A. M.; Martín, I.; Lavín, C.


Induction of Macrophage Migration Inhibitory Factor in ConA-Stimulated Rheumatoid Arthritis Synovial Fibroblasts through the P38 MAP Kinase-Dependent Signaling Pathway  

PubMed Central

Background/Aims This study was undertaken to identify the intracellular signaling pathway involved in induction of macrophage migration inhibitory factor (MIF) in human rheumatoid arthritis (RA) synovial fibroblasts. Methods Human RA synovial fibroblasts were treated with concanavalin A (ConA), various cytokines, and inhibitors of signal transduction molecules. The production of MIF by synovial fibroblasts was measured in culture supernatants by ELISA. The expression of MIF mRNA was determined using reverse transcriptase polymerase chain reaction (RT-PCR) and real-time PCR. Phosphorylation of p38 mitogen-activated protein (MAP) kinase in synovial fibroblasts was confirmed using Western blotting. The expression of MIF and p38 MAP kinase in RA synovium was determined using dual immunohistochemistry. Results The production of MIF by RA synovial fibroblasts increased in a dose-dependent manner after ConA stimulation. MIF was also induced by interferon-?, CD40 ligand, interleukin-15, interleukin-1?, tumor necrosis factor-?, and transforming growth factor-?. The production of MIF by RA synovial fibroblasts was significantly reduced after inhibition of p38 MAP kinase. The expression of MIF and p38 MAP kinase was upregulated in the RA synovium compared with the osteoarthritis synovium. Conclusions These results suggest that MIF production was induced through a p38 MAP-kinase-dependent pathway in RA synovial fibroblasts.

Kim, Hae-Rim; Park, Mi-Kyung; Kim, Kyoung-Woon; Oh, Hye-Joa; Park, Jin-Sil; Heo, Yang-Mi; Lee, Sang-Heon; Kim, Ho-Youn



The International Consortium on Lithium Genetics (ConLiGen): An Initiative by the NIMH and IGSLI to Study the Genetic Basis of Response to Lithium Treatment  

PubMed Central

For more than half a decade, lithium has been successfully used to treat bipolar disorder. Worldwide, it is considered the first-line mood stabilizer. Apart from its proven antimanic and prophylactic effects, considerable evidence also suggests an antisuicidal effect in affective disorders. Lithium is also effectively used to augment antidepressant drugs in the treatment of refractory major depressive episodes and prevent relapses in recurrent unipolar depression. In contrast to many psychiatric drugs, lithium has outlasted various pharmacotherapeutic ‘fashions’, and remains an indispensable element in contemporary psychopharmacology. Nevertheless, data from pharmacogenetic studies of lithium are comparatively sparse, and these studies are generally characterized by small sample sizes and varying definitions of response. Here, we present an international effort to elucidate the genetic underpinnings of lithium response in bipolar disorder. Following an initiative by the International Group for the Study of Lithium-Treated Patients ( and the Unit on the Genetic Basis of Mood and Anxiety Disorders at the National Institute of Mental Health, lithium researchers from around the world have formed the Consortium on Lithium Genetics ( to establish the largest sample to date for genome-wide studies of lithium response in bipolar disorder, currently comprising more than 1,200 patients characterized for response to lithium treatment. A stringent phenotype definition of response is one of the hallmarks of this collaboration. ConLiGen invites all lithium researchers to join its efforts.

Schulze, Thomas G.; Alda, Martin; Adli, Mazda; Akula, Nirmala; Ardau, Raffaella; Bui, Elise T.; Chillotti, Caterina; Cichon, Sven; Czerski, Piotr; Del Zompo, Maria; Detera-Wadleigh, Sevilla D.; Grof, Paul; Gruber, Oliver; Hashimoto, Ryota; Hauser, Joanna; Hoban, Rebecca; Iwata, Nakao; Kassem, Layla; Kato, Tadafumi; Kittel-Schneider, Sarah; Kliwicki, Sebastian; Kelsoe, John R.; Kusumi, Ichiro; Laje, Gonzalo; Leckband, Susan G.; Manchia, Mirko; MacQueen, Glenda; Masui, Takuya; Ozaki, Norio; Perlis, Roy H.; Pfennig, Andrea; Piccardi, Paola; Richardson, Sara; Rouleau, Guy; Reif, Andreas; Rybakowski, Janusz K.; Sasse, Johanna; Schumacher, Johannes; Severino, Giovanni; Smoller, Jordan W.; Squassina, Alessio; Turecki, Gustavo; Young, L. Trevor; Yoshikawa, Takeo; Bauer, Michael; McMahon, Francis J.



A wireless, remote-query and high sensitivity Escherichia coli O157: H7 biosensor based on the recognition action of Con A  

PubMed Central

Escherichia coli O157: H7 is detected using a remote-query (wireless, passive) magnetoelastic sensor platform to which a 1 µm-thick layer of Bayhydrol 110 and then a layer of functionalized mannose is applied. The multivalent binding of lectin concanavalin A (Con A) to the E. coli surface O-antigen and mannose favors the strong adhesion of E. coli to the mannose modified magnetoelastic sensor; E. coli is rigidly and strongly attached on the mannose-modified sensor through Con A, which works as a bridge to bind to the E. coli surface O-antigen and mannose modified sensor surface. As E. coli is bound to the sensor its resonance frequency shifts, enabling quantification of E. coli concentration with a limit of detection of 60 cells/mL and a linear logarithmic response range of 6.0×101 to 6.1×109 cells/mL. The analysis can be directly conducted without incubation, and completed in 3 h or less.

Lu, Qingzhu; Lin, Hailan; Ge, Shutian; Luo, Shenglian; Cai, Qingyun; Grimes, Craig A.



The Effect of Coadsorbed Water on the Stability, Con?guration and Interconversion of Formyl (HCO) and Hydroxymethylidyne (COH) on Platinum (1 1 1)  

SciTech Connect

Two forms of the methanol electro-oxidation intermediate with stoichiometry C:H:O, COH (hydroxymethylidyne) and HCO (formyl), on Pt (11 1) with and without coadsorbed water were studied using density functional theory calculations. The structure, adsorption energy and stability with respect to dissociation were calculated. Both HC=O and C–OH were stable on clean Pt (11 1) and with a single coadsorbed water molecule, while only the HCO con?guration was stable in the presence of a whole water layer. The vibrational modes of HC=O on a bridge site showed no mode around 1700 cm-1 characteristic of C=O stretch making it hard to distinguish it from C–OH.

Arnadottir, Liney; Stuve, Eric M.; Jonsson, Hannes



Broadening, shifting, and line asymmetries in the 2<--0 band of CO and CO-N2: Experimental results and theoretical calculations  

NASA Astrophysics Data System (ADS)

We have measured the room temperature, widths, pressure shifts, and line asymmetry coefficients for many transitions of the first overtone band of CO and CO perturbed by N2. The broadening coefficients were obtained with an accuracy of about 1%. The pure CO profiles have been fitted by a Voigt profile while the CO-N2 spectral profiles have been fitted with a Lorentz and an empirical line shape model (HCv) that blends together a hard collision model and a speed-dependent Lorentz profile. In addition to the Voigt, Lorentz, and HCv models, we have added a dispersion profile to account for weak line mixing. The line broadening and shift coefficients are compared to semiclassical calculations employing a variety of intermolecular interactions. The line asymmetry results are compared to line mixing calculations based on the energy corrected sudden (ECS) model. The results indicate that effects other than line mixing also contribute to the measured line asymmetry.

Predoi-Cross, Adriana; Bouanich, J. P.; Benner, D. Chris; May, A. D.; Drummond, J. R.



Hydrogen adsorption and magnetic behavior of Fen and Con clusters: Controlling the magnetic moment and anisotropy one atom at a time  

NASA Astrophysics Data System (ADS)

Theoretical studies to investigate the effect of H absorption on the magnetic moment of small Fen and Con clusters have been carried out using gradient corrected density-functional approach. Our studies on clusters containing up to four transition metal and 2 H atoms show that the successive addition of H atoms can lead to monotonic or oscillatory change from the free cluster magnetic moment. A detailed analysis of the density of electronic states shows that the variations in the magnetic moment can be related to the location of the lowest unoccupied molecular orbital in the parent cluster. It is shown that the addition of hydrogen can substantially change the magnetic anisotropy. In particular Co3H2 is shown to exhibit magnetic anisotropy that is higher than any of the known anisotropies in the molecular nanomagnets.

Jones, N. O.; Beltran, M. R.; Khanna, S. N.; Baruah, T.; Pederson, M. R.



Intracellular free zinc up-regulates IFN-? and T-bet essential for Th1 differentiation in Con-A stimulated HUT-78 cells  

PubMed Central

Zinc deficiency impairs cellular immunity. Up-regulation of mRNA levels of IFN-?, IL-12R?2, and T-bet are essential for Th1 differentiation. We hypothesized that zinc increases Th1 differentiation via up-regulation of IFN-? and T-bet expression. To test this hypothesis, we used zinc-deficient and zinc-sufficient HUT-78 cells (a Th0 cell line) under different condition of stimulation in this study. We also used TPEN, a zinc-specific chelator, to decrease the bioavailability of zinc in the cells. We measured intracellular free zinc, cytokines, and the mRNAs of T-bet, IFN-?, and IL-12R?2. In this study, we show that in zinc-sufficient HUT-78 cells (a Th0 cell line), mRNA levels of IFN-?, IL-12R?2, and T-bet in PMA/PHA-stimulated cells were increased in comparison to zinc-deficient cells. Although intracellular free zinc was increased slightly in PMA/PHA-stimulated cells, Con-A-stimulated cells in 5 ?M zinc medium showed a greater sustained increase in intracellular free zinc in comparison to cells incubated in 1 ?M zinc. The cells pre-incubated with TPEN showed decreased mRNA levels of IFN-? and T-bet mRNAs in comparison to cells without TPEN incubation. We conclude that stimulation of cells by Con-A via TCR, release intracellular free zinc which functions as a signal molecule for generation of IFN-? and T-bet, and IL-12Rb?2 mRNAs required for Th1 cell differentiation. These results suggest that zinc increase Th1 cell differentiation by up-regulation of IFN-? and T-bet, and IL-12Rb?2 mRNAs.

Bao, Bin; Prasad, Ananda S.; Beck, Frances WJ; Bao, Ginny W.; Singh, Tapinder; Ali, Shadan; Sarkar, Fazlul H.



Actitudes de madres adolescentes y adultas y su relación con la personalidad de sus hijos Attitudes of adolescent and adult mothers and their relation with their children's personality profile  

Microsoft Academic Search

La presente investigación tuvo el propósito de indagar si hay diferencias entre las actitudes de las madres adolescentes y adultas e identificar si existe una relación entre las actitudes de las madres y el perfil de personalidad de sus hijos. Participaron 35 mujeres con sus hijos, quienes cursaban el primer grado de primaria; 17 fueron madres siendo adolescentes y 18

Iris Xóchitl; Galicia Moyeda; Lucina Jiménez Vega; Susana Pavón Figueroa; Alejandra Sánchez Velasco



Liberación\\/mineralización de nitrógeno en hojarasca de Eucalyptus grandis y leguminosas herbáceas, su relación con la calidad física y química del residuo y su efecto sobre el crecimiento de plantas jóvenes de eucalipto  

Microsoft Academic Search

Resumen El tipo de cosecha y manejo de residuos inciden en el contenido de nutrientes del suelo y la productividad forestal. Estos residuos contienen la mayoría del retorno de N. La velocidad de provisión de nutrientes por la descomposición\\/mineralización puede verse afectada por la calidad química y física como por la localización y contacto de los residuos con el suelo.

Alcaraz Maria Luciana



Microsoft Academic Search

Knowledge about model uncertainty is essential for crop modelling and provides information crucial for a real understand- ing of models behavior and for parameterization purposes. This work addresses an exploratory sensitivity analysis on the parameters involved with biomass accumulation of three crop models decidedly differing in the way they interpret the con- cept of growth. The models used in the

Roberto Confalonieri; Marco Acutis; Gianni Bellocchi; Iacopo Cerrani; Stefano Tarantola; Marcello Donatelli; Giampiero Genovese


Monitoreo de ecosistemas con estrategias geoestadísticas, una aplicación de gran escala en Jalisco, México Ecosystem monitoring through the use of geostatistic strategies, a large scale application in Jalisco, Mexico  

Microsoft Academic Search

RESUMEN El proyecto de Inventario y Monitoreo de los Recursos Naturales de Jalisco, México (IMRENAT), es un proceso innovador que propone una aplicación práctica de las herramientas de modelado esta- dístico geoespacial para reportar creíblemente la condición del territorio. Aprovechando las intercone- xiones que existen entre atributos del terreno, la vegetación, las actividades humanas y lo detectable con sensores remotos

José Germán Flores Garnica; Martín Alfonso; Celedonio Aguirre Bravo


Eficacia del tratamiento con leflunomida en pacientes con artritis psoriásica  

Microsoft Academic Search

Psoriatic arthritis (PsA) occurs in 1-3% of the population and 25% of affected patients require systemic therapy. The drugs used in PsA have been developed for other diseases, mainly rheumatoid arthritis (RA), and there are no clinical trials supporting their efficacy and safety in these patients. Leflunomide (LFN) inhibits the activation and proliferation of T-lymphocytes and is considered to be

Ingrid Möller



A novel mammalian myosin I from rat with an SH3 domain localizes to Con A-inducible, F-actin-rich structures at cell-cell contacts  

PubMed Central

In an effort to determine diversity and function of mammalian myosin I molecules, we report here the cloning and characterization of myr 3 (third unconventional myosin from rat), a novel mammalian myosin I from rat tissues that is related to myosin I molecules from protozoa. Like the protozoan myosin I molecules, myr 3 consists of a myosin head domain, a single light chain binding motif, and a tail region that includes a COOH-terminal SH3 domain. However, myr 3 lacks the regulatory phosphorylation site present in the head domain of protozoan myosin I molecules. Evidence was obtained that the COOH terminus of the tail domain is involved in regulating F-actin binding activity of the NH2-terminal head domain. The light chain of myr 3 was identified as the Ca(2+)-binding protein calmodulin. Northern blot and immunoblot analyses revealed that myr 3 is expressed in many tissues and cell lines. Immunofluorescence studies with anti-myr 3 antibodies in NRK cells demonstrated that myr 3 is localized in the cytoplasm and in elongated structures at regions of cell-cell contact. These elongated structures contained F-actin and alpha-actinin but were devoid of vinculin. Incubation of NRK cells with Con A stimulated the formation of myr 3-containing structures along cell-cell contacts. These results suggest for myr 3 a function mediated by cell-cell contact.



Observations on the effects of inhaled isoflurane in long-term sedation of critically Ill children using a modified AnaConDa©-system.  


Long-term intravenous sedation may present problems due to dependence and side effects. Medical records of children who were administered isoflurane were reviewed. 15 patients (9 boys, 6 girls) with a mean age of 11.8 month (+2.4) were analysed.Analgesia and sedation was given in mean 9.7+1.1 days before commencing inhalation using a modified application device (AnaConDa©). Administration was given over a period of 7.2+1.4 days. Depth of sedation was monitored by using Comfort- and Hartwig-scores. Observations included continuous monitoring of heart-rate, pulse oxymetry, blood pressure and cerebral tissue oxygenation.Within 4 h post administration of isoflurane a satisfactory increase in the depth of sedation was seen and kept till extubation. 6/15 patients received tracheostomies during the observation period. None of the patients observed suffered life-critical events of the modified application of isoflurane proceeded without complications. Ketamine and clonidine infusion rates were significantly reduced (p<0.005) as well as the use and overall infusion rate of midazolam, ?-hydroxy butyrate, fentanyl and morphine (p<0.05).Isoflurane inhalation may provide an additional option for long-term sedation in a specific group of critically ill infants but neurodegenerative toxic effects will have to be taken into account when using volatile anesthetics at any time during infancy. PMID:23797368

Eifinger, F; Hünseler, C; Roth, B; Vierzig, A; Oberthuer, A; Mehler, K; Kribs, A; Menzel, C; Trieschmann, U



Biochar Usage: Pros and Cons  

Technology Transfer Automated Retrieval System (TEKTRAN)

Soil fertility benefits of charcoal application have been reported as early as 1847 indicating that plant nutrients are sorbed within charcoal pores. The use of biomass-derived black carbon or biochar, the solid byproduct from the pyrolysis processing of any organic feedstock, has garnered recent a...


Quality of life and psycho-social development in children with otitis media with effusion Qualità di vita e sviluppo psico-sociale nei bambini con otite media secretiva  

Microsoft Academic Search

th class, mostly due to persistent attention disturbances. In the State-Trait Anxiety Inventory test, 50% of parents or care- givers had a high state-anxiety score and so were mostly con- cerned with health status of the children. The State-Trait Anx- iety Inventory results indicated that 50% of parents or care- givers had a high trait-anxiety score and thus had an



Comparison between dynamic cystocolpoproctography and dynamic pelvic floor MRI: pros and cons: Which is the "functional" examination for anorectal and pelvic floor dysfunction?  


"Functional" imaging of anorectal and pelvic floor dysfunction has assumed an important role in the diagnosis and management of these disorders. Although defecography has been widely practiced for decades to evaluate the dynamics of rectal emptying, debate concerning its clinical relevance, how it should be done and interpreted continues. Due to the recognition of the association of defecatory disorders with pelvic organ prolapse in women, the need to evaluate the pelvic floor as a unit has arisen. To meet this need, defecography has been extended to include not only evaluation of defecation disorders but also the rest of the pelvic floor by opacifying the small bowel, vagina, and the urinary bladder. The term "dynamic cystocolpoproctography" (DCP) has been appropriately applied to this examination. Rectal emptying performed with DCP provides the maximum stress to the pelvic floor resulting in complete levator ani relaxation. In addition to diagnosing defecatory disorders, this method of examination demonstrates maximum pelvic organ descent and provides organ-specific quantification of organ prolapse, information that is only inferred by means of physical examination. It has been found to be of clinical value in patients with defecation disorders and the diagnosis of associated prolapse in other compartments that are frequently unrecognized by history taking and the limitations of physical examination. Pelvic floor anatomy is complex and DCP does not show the anatomical details pelvic magnetic resonance imaging (MRI) provides. Technical advances allowing acquisition of dynamic rapid MRI sequences has been applied to pelvic floor imaging. Early reports have shown that pelvic MRI may be a useful tool in pre-operative planning of these disorders and may lead to a change in surgical therapy. Predictions of hypothetical increase cancer incidence and deaths in patients exposed to radiation, the emergence of pelvic floor MRI in addition to questions relating to the clinical significance of DCP findings have added to these controversies. This review analyses the pros and cons between DCP and dynamic pelvic floor MRI, addresses imaging and interpretive controversies, and their relevance to clinical management. PMID:22446896

Maglinte, Dean D T; Hale, Douglass S; Sandrasegaran, Kumar



Do not disturb the animals! or, how Con Edison saved $300,000 using a trenchless technology to renew 3,000 feet of leaking gas main at the Bronx Zoo  

SciTech Connect

Every leaking gas main presents a challenge. But when that leaking main follows a series of sweeping bends on its route through North America`s largest urban wildlife park, it presents a special challenge. That was the situation Consolidated Edison Company of New York Inc. recently faced when numerous leaks were discovered along 3,000 feet of a 95-year-old, 12-inch cast-iron main that winds through New York City`s Bronx Zoo. Con Edison knew it needed a long-term solution to this increasingly common problem. Thanks to the cooperative efforts of the utility`s operations and research departments and the Gas Research Institute (GRI), Con Edison also knew about a trenchless technology that could renew the pipe with minimal impact to the environment--while saving the utility a substantial sum of money in the process. In the Paltem system, a woven polyester hose is injected with an epoxy resin and then inverted (turned inside out) into a pipe at an access pit. The liner then bonds to the inside wall of the pipe, forming a smooth, flexible and pressure-resistant lining. The process is environmentally safe, requires very little excavation and can be installed in days, rather than the weeks or months it can take to dig up and replace existing pipe.

Bufe, M.



Signals provided in vivo by human rIL-2 and Con A can switch hapten-specific tolerance from unresponsiveness to responsiveness in the South African clawed toad.  

PubMed Central

Injection in vivo of trinitrobenzene sulphonic acid (TNBS) will conjugate trinitrophenyl (TNP) to the cells and proteins of rodents, and induce hapten-specific tolerance to this epitope. However, the induction of hapten-specific tolerance by this method in the South African clawed toad, Xenopus laevis, is restricted to its subsequent presentation on Ficoll or polyvinylpyrrolidone (PVP). This restricted tolerance depends on the stimulation of an N-methyl-N-nitrosourea (NMU)-insensitive, cyclophosphamide (CyP)-sensitive hapten-specific (suppressor) population that is functionally demonstrable in vitro. Unresponsiveness to TNP-Ficoll can be switched to responsiveness by injection in vivo of recombinant DNA-produced human IL-2 (rIL-2) or the plant-derived lectin, concanavalin A (Con A). Responsiveness to TNP-Ficoll requires thymic presence, although thymic extracts from rIL-2- or Con A-injected toads will suffice. Unresponsiveness to TNP-PVP can also be broken by these reagents, but thymic presence is not required with this immunogen. TNP-Ficoll responses are thymus requiring, while those to TNP-PVP are not, in the toad. Since TNBS failed to stimulate hapten-specific tolerance to a secondary challenge to TNP-Ficoll, we suggest that the suppressor function involved in the establishment of the unresponsive state may act on the differentiation, rather than on the function, of the relevant B cells.

Ruben, L N; Clothier, R H; Mirchandani, M; Wood, P; Balls, M



Clinico-epidemiological profile of oral potentially malignant and malignant conditions among areca nut, tobacco and alcohol users in Eastern India: A hospital based study  

PubMed Central

Context: With an increase in the abuse of various oral habitual products in India over the past few decades; the incidence of oral potentially malignant conditions as leukoplakia, oral submucous fibrosis and squamous cell carcinoma (SCC) rates have also increased. No recent study has been conducted reporting the scenario of oral cancer and potentially malignant conditions in Eastern India (specifically Kolkata). Aims: The present study was conducted at Dr. R. Ahmed Dental College, Kolkata during 2010-2011 to find a possible correlation between the effects of the different oral habits, age, sex and the different types of oral mucosal lesions among patients reported to the hospital. This study also enabled us to see the predilection of the various histopathological stages of the lesions for different sites of the oral cavity. Subjects and Methods: The study group consisted of 698 patients having either oral potentially malignant or malignant lesion. The control group consisted of 948 patients who had reported to the hospital for different oral/dental problems and had the habit of tobacco, areca nut and/or alcohol usage for at least 1 year. Statistical Analysis: The unadjusted odds ratio, the 95% confidence interval, and the P value were calculated to correlate patients with/without different kinds of habit and having/not having various kinds of oral lesions. Results: Our study shows that for males having the habit of taking smokeless tobacco or mixed habit poses the highest risk for developing SCC. For females, significant risk of developing SCC was found in patients habituated to processed areca nut chewing. Conclusion: This study presents probably for the first time in recent years the occurrence of oral potentially malignant and malignant conditions amongst patients having deleterious habits in a hospital based population of Kolkata.

Ray, Jay Gopal; Ganguly, Madhurima; Rao, BH Sripathi; Mukherjee, Sanjit; Mahato, Basudev; Chaudhuri, Keya



A Study on the Clinico-Epidemiological Profile and the Outcome of Snake Bite Victims in a Tertiary Care Centre in Southern India  

PubMed Central

Background: Snake bite is a common medical emergency and an occupational hazard, more so in tropical India, where farming is a major source of employment. The available data on the epidemiology of snake bite from the Indian subcontinent are sparse. Snake bite is a neglected disease that afflicts the most impoverished inhabitants of the rural areas in the tropical developing countries. Aims: This study was carried out to describe the epidemiology, arrival delays, clinical features, complications, and the outcome of snakebites which were seen in a tertiary care hospital of southern India. Setting: Sri Chamarajendra District Hospital which is attached to the Hassan Institute of Medical Sciences, Hassan, Karnataka, India. Study Design: A record–based, retrospective, descriptive study. Materials and Methods: One hundred eighty patients of snake bite were studied from January 2010 to December 2011. The data on the demographic factors, clinical features and complications, details of the treatment which was received and the outcome of the snake bite victims were recorded and analyzed. Results: Among a total 180 cases of snake bite, there were 108 cases of viper bite which presented with haematotoxic manifestations and 74 elapid bites had neuroparalytic manifestations. The victims were predominantly males (60.5%) and they were aged 20-40 years. A majority of the victims are from the rural areas (81.1%) and most of the bites occurred during the day time (70.5%), mainly on the lower limbs (67.2%). The highest number of cases occurred during July- September. Most of the victims were farmers (54.4%) and plantation workers (30.5%), which suggested that snake bite was an occupational hazard. A reaction to the ASV was noted in 12.7% of the patients and the mortality rate in our study was 3.8%. Conclusion: In the tropics, snake bite is a rural and an occupational hazard among farmers, plantation workers, herders and hunters. Regular public health programmes regarding the prevention, pre –hospital management (first aid) and the importance of the early transfer to the hospital should be emphasized.

B.R., Halesha; L., Harshavardhan; A J., Lokesh; P.K., Channaveerappa; K.B, Venkatesh



A study on the clinico-epidemiological profile and the outcome of snake bite victims in a tertiary care centre in southern India.  


Background: Snake bite is a common medical emergency and an occupational hazard, more so in tropical India, where farming is a major source of employment. The available data on the epidemiology of snake bite from the Indian subcontinent are sparse. Snake bite is a neglected disease that afflicts the most impoverished inhabitants of the rural areas in the tropical developing countries.Aims: This study was carried out to describe the epidemiology, arrival delays, clinical features, complications, and the outcome of snakebites which were seen in a tertiary care hospital of southern India.Setting: Sri Chamarajendra District Hospital which is attached to the Hassan Institute of Medical Sciences, Hassan, Karnataka, India.Study Design: A record-based, retrospective, descriptive study.Materials and Methods: One hundred eighty patients of snake bite were studied from January 2010 to December 2011. The data on the demographic factors, clinical features and complications, details of the treatment which was received and the outcome of the snake bite victims were recorded and analyzed.Results: Among a total 180 cases of snake bite, there were 108 cases of viper bite which presented with haematotoxic manifestations and 74 elapid bites had neuroparalytic manifestations. The victims were predominantly males (60.5%) and they were aged 20-40 years. A majority of the victims are from the rural areas (81.1%) and most of the bites occurred during the day time (70.5%), mainly on the lower limbs (67.2%). The highest number of cases occurred during July- September. Most of the victims were farmers (54.4%) and plantation workers (30.5%), which suggested that snake bite was an occupational hazard. A reaction to the ASV was noted in 12.7% of the patients and the mortality rate in our study was 3.8%.Conclusion: In the tropics, snake bite is a rural and an occupational hazard among farmers, plantation workers, herders and hunters. Regular public health programmes regarding the prevention, pre -hospital management (first aid) and the importance of the early transfer to the hospital should be emphasized. PMID:23450135

B R, Halesha; L, Harshavardhan; A J, Lokesh; P K, Channaveerappa; K B, Venkatesh



Pauci-immune necrotizing crescentic glomerulonephritis with crescentic and full moon extracapillary proliferation: clinico-pathologic correlation and follow-up study.  


The prognostic value of the type and extent of extracapillary proliferation (ECP) in pauci-immune necrotizing crescentic glomerulonephitis (PIGN) was evaluated in this study. In 141 PIGN cases, all glomeruli with ECP were grouped according to type (cellular, fibrocellular and fibrous) and extent of the lesions in Bowman's space; (segmental, semicircumferential and circumferential, which might be termed full moon-FM). Cases with cellular and fibrous lesions involving ? 50% of glomeruli with ECP were classified as cellular and fibrous groups, respectively, while the remaining cases were classified as fibrocellular. Cases with segmental and circumferential (FM glomerulus) lesions involving ? 50% of glomeruli with ECP were classified as ECPI and ECPIII (FM) groups, respectively, while the rest were classified as ECPII. All the cases were classified according to Berden et al. Significant results were only nearly obtained for the FM group, including the need for dialysis. The Cox regression model revealed a 2.6-fold risk for FM cases regarding dialysis requirement. We propose that the percentage of FM glomeruli should be noted in the pathology report, and cases with more than 50% of FM glomeruli (FM group) should be identified in the group with increased risk of dialysis requirement. Our series also suggests that classification according to Berden et al. is of clinical relevance. PMID:23246377

Unlu, Mehtat; Kiremitci, Saba; Ensari, Arzu; Ozluk, Yasemin; Kilicaslan, Isin; Ozdemir, Binnaz Handan; Ates, Deniz; Ertoy Baydar, Dilek; Gonul, Ipek Isik; Memis, Leyla; Sarsik, Banu; Sen, Sait; Akkaya, Bahar; Orhan, Diclehan; Gonlusen, Gulfiliz; Ellidokuz, Hulya; Ada, Sibel; Cavdar, Caner; Akagun, Tulin; Kamali, Sevil; Aksu, Kenan; Yazisiz, Veli; Paydas, Saime; Soylu, Alper; Sarioglu, Sulen



Clinical progression in Charcot–Marie-Tooth disease type 1A duplication: clinico-electrophysiological and MRI longitudinal study of a family  

Microsoft Academic Search

Long-term follow-up studies in Charcot–Marie-Tooth disease type 1 duplication (CMT1A) are scanty. Here we describe a longitudinal\\u000a study in a CMT1A pedigree. Our CMT1A pedigree comprised 11 examined patients, ages between 13 and 83 (median, 36) years, serially\\u000a evaluated for up to 26 years. In all 11 patients we carried out electrophysiological evaluation, and in three of them magnetic\\u000a resonance imaging

José Berciano; Elena Gallardo; Antonio García; César Ramón; Jon Infante; Onofre Combarros



[Intestinal trematodiases (metagonimiasis, nanophyetiasis): clinico-parasitological research and the first trial of using Azinox in a focus of the lower Amur River valley].  


A focus of metagonimiasis and nanophyetiasis is described with the average human prevalence of 66.7 and 4.2%, respectively and low intensity of invasions (less than 100 eggs per 1 g). Metagonimiasis and nanophyetiasis are clinically expressed as chronic enterocolitis. A high effect of a single dose 10 mg/kg of azinox against metagonimiasis (98%) and nanophyetiasis (100%) was shown. The treatment course was proved to be useful in the foci of the Amur basin. PMID:1435530

Bronshte?n, A M; Korablev, V N; Iarotski?, L S


Clinico-epidemiological profile and high-level aminoglycoside resistance in enterococcal septicemia from a tertiary care hospital in east Delhi  

PubMed Central

Background: Emergence of high-level aminoglycoside and glycopeptide resistance has significantly contributed to the mortality, particularly in serious enterococcal infections. Objectives: This study was aimed to determine the prevalence of high-level gentamicin resistance (HLGR), high-level streptomycin resistance (HLSR) and vancomycin resistance in enterococcal isolates recovered from patients with bacteremia. Materials and Methods: A total of 110 blood culture isolates of enterococci were recovered from septicemic patients. Routine antibiotic susceptibility testing was performed and screening for ampilcillin, high-level aminoglycoside resistance (HLAR) and high-level vancomycin resistance was done by agar screen method. Results: Out of 110 isolates, Enterococcus faecium accounted for 53% of these isolates, followed by Enterococcus fecalis (33%), Enterococcus casseliflavus (8%), Enterococcus raffinosus (4%) and Enterococcus dispar (2%). Resistance to ampicillin, HLGR, HLSR and HLAR was detected in 58%, 62%, 58% and 54% of the isolates, respectively. No isolate was resistant to vancomycin. Conclusion: This study illustrates the high prevalence of HLAR in enterococci from patients with septicemia in our region, which emphasizes the need to predict synergy between beta-lactams and aminoglycosides for management of enterococcal infections.

Jain, Sarika; Kumar, Ashwani; Kashyap, Bineeta; Kaur, Iqbal R



The expression of gene transcripts of telomere-associated genes in human breast cancer: correlation with clinico-pathological parameters and clinical outcome  

Microsoft Academic Search

Background: Telomerase is a ribonucleoprotein enzyme that synthesises telomeres in human germ cells, embryogenesis and in cancer, maintaining\\u000a chromosomal length, stability and cellular immortality. The hTERT gene is the rate-limiting determinant of telomerase reactivation\\u000a during immortalization and malignant transformation. Telomeric DNA-binding proteins have been attracting increasing interest\\u000a due to their essential role in the regulation of telomeric DNA length and

Mohamed Salhab; Wen G. Jiang; Robert F. Newbold; Kefah Mokbel



Validità del dato analitico del laboratorio chimico clinico e tossicologico Validity of the analytical data of the chemical-clinical and toxicological laboratory  

Microsoft Academic Search

Analytical measurements provided for high import purposes such as health care, environmental conservation, public utilities, public interest issues and particularly forensic applications must be reliable. An essential requirement for achieving high reliabi- lity is the rigorous control of the quality of analytical data. Homogeneity both in quality definition and parameters in accordance with the latest European directives is a requirement



[The effect of the ecologically adverse factors of a Donets Basin industrial region on the clinico-immunological indices of patients with viral hepatitis A and B].  


Clinicoimmunological features of viral hepatitis A and B (VH A and VH B) were studied in residents of unfavorable (from the environmental standpoint) regions. 180 VH A, 86 VII B patients were examined. Clinical picture of VH was characterized by predominance of more severe forms, frequent occurrence of cholestatic variant of VH, high rate of protracted and recurrent (in VH B) course of VH, hepato- and splenomegaly of long duration. The immunologic status was characterized by more pronounced T-lymphopenia, noticeable imbalance of T-helpers and T-suppressors, decrease in the level of immunoglobulins, as well as in phagocytic activity of neutrophilic granulocytes and monocytes in peripheral blood. The use of adaptogens and antioxidants in multimodality treatment promotes rapid normalization of clinicoimmunological parameters in VH. PMID:7831925

Petrunia, A M; Frolov, V M; Peresadin, N A; Dekaliuk, I V


Effect of Helicobacter pylori infection, smoking and dietary habits on the occurrence of antrum intestinal metaplasia. Clinico-epidemiological study in Poland.  


The purpose of the study was to assess risk factors for intestinal metaplasia arising from H. pylori-related chronic gastritis in a subset of the population referred to endoscopic examinations due to dyspeptic complaints. We aimed specifically to establish whether H. pylori itself may be responsible for the occurrence of intestinal metaplasia and to which extent the metaplasia may be associated with life style factors such as cigarette smoking, alcohol consumption or dietary habits. The study was carried out in a sample of 1290 outpatients referred for the first time to gastroenterologic outpatient clinics in 6 university centers in Poland. The study methods covered standardized health interviews, endoscopy and histology of gastric antral specimens taken at endoscopy. The interviews performed by trained interviewers sought information on tobacco and alcohol intake, diet, socioeconomic status, and other variables. In non-ulcer dyspepsia subjects there was 54.9% H. pylori related gastritis and 25.1% of non-H. pylori-related gastritis. The corresponding rates in the group of ulcer dyspepsia were 67.5% and 20.5%. The increased risk of chronic gastritis in antrum was associated with Helicobacter pylori infection (OR = 2.28; 95% CI:1.93-2.69), and with gastric peptic ulcer (OR = 1.88; 95% CI:1.20-2.94). In the non-ulcer dyspepsia the prevalence of metaplasia was 11.1% and in ulcer dyspepsia 19.7%. The risk of intestinal metaplasia within antrum depended greatly upon the presence of gastric peptic ulcer (OR = 3.85; 95% CI:2.35-6.32) and increased with age (OR = 1.05; 95% CI:1.04-1.07), smoking cigarettes currently or in the past (OR = 1.42; 95% CI:1.10-1.84), higher frequency of drinking vodka (OR = 1.32, 95% CI:1.01-1.75) and antral chronic gastritis (OR = 1.31; 95% CI:1.00-1.70), however, it was inversely related to daily consumption of fresh fruits or vegetables (OR = 0.59; 95% CI:0.38-0.93). The results of the study suggest that there is no sufficient evidence supporting the hypothesis about an association between H. pylori gastritis and intestinal metaplasia, however, the transition of gastritis to metaplasia depends greatly on life style factors such as cigarette smoking or vodka drinking and is impeded by daily consumption of fresh fruits or vegetables. PMID:10721269

Jedrychowski, W; Popiela, T; Drews, M; Gabryelewicz, A; Marlicz, K; Misiunia, P; Wajda, Z; Matyja, A; Nowak, K; Ramroth, H; Wahrendorf, J



Evaluation of bioactive glass and demineralized freeze dried bone allograft in the treatment of periodontal intraosseous defects: A comparative clinico-radiographic study  

PubMed Central

Aim: The purpose of this study was to evaluate the efficacy of demineralized freeze dried bone allograft (DFDBA) and bioactive glass by clinically and radiographically in periodontal intrabony defects for a period of 12 months. Materials and Methods: Ten systemically healthy patients diagnosed with chronic periodontitis, with radiographic evidence of at least a pair of contralateral vertical osseous defects were included in this study. Defect on one-side is treated with DFDBA and the other side with bioactive glass. Clinical and radiographic measurements were made at baseline 6 month and 12 month after the surgery. Results: Compared to baseline, the 12 month results indicated that both treatment modalities resulted in significant changes in all clinical parameters (gingival index, probing depth, clinical attachment level (CAL) and radiographic parameters (bone fill); P < 0.001*). However, sites treated with DFDBA exhibited statistically significantly more changes compared to the bioactive glass in probing depth reduction (2.5 ± 0.1 mm vs. 1.8 ± 0.1 mm) CAL gain 2.4 ± 0.1 mm versus 1.7 ± 0.2 mm; (P < 0.001*). At 12 months, sites treated with bioactive glass exhibited 56.99% bone fill and 64.76% bone fill for DFDBA sites, which is statistically significant (P < 0.05*). Conclusion: After 12 months, there was a significant difference between the two materials with sites grafted with DFDBA showing better reduction in probing pocket depth, gain in CAL and a greater percentage of bone fill when compared to that of bioactive glass.

Katuri, Kishore Kumar; Kumar, P. Jaya; Swarna, Chakrapani; Swamy, D. Narasimha; Arun, Kurumathur V.



Comparison of matrix metalloproteinase-3 and tissue inhibitor of matrix metalloproteinase-1 levels in gingival crevicular fluid in periodontal health, disease and after treatment: A clinico biochemical study  

PubMed Central

Background: Considering the role of matrix metalloproteinase-3 (MMP-3) and tissue inhibitor of matrix metalloproteinase-1 (TIMP-1) in the pathogenesis of periodontitis, the present study is to estimate the levels of MMP-3 and TIMP-1 in gingival crevicular fluid (GCF) in periodontal health, disease and to evaluate the effect of periodontal therapy on MMP-3 and TIMP-1 concentrations in GCF. Materials and Methods: A periodontal examination and collection of GCF by extra-crevicular method was performed in 30 subjects selected randomly and categorized into 3 groups. Group I consists of 10 subjects Group II consists of 20 patients and Group III consists of 20 patients of Group II. Non surgical periodontal therapy was performed, and GCF was collected after 8 weeks from the same site of 20 chronic periodontitis patients who are considered as Group III. MMP-?3 and TIMP-1 levels were estimated in GCF-samples by using enzyme-linked immunosorbent assay. The findings were analyzed using the software and descriptive statistical methods such as Mann-?Whitney U-test and Kruskal-Wallis test. P value < 0.001 was considered significant. Results: MMP-3 and TIMP-1 was detected in all samples. Highest mean MMP-3 concentrations in GCF were obtained for Group II (7.490 ng/ml) while the lowest concentrations were seen in Group I (0.344 ng/ml) and Group III (2.129 ng/ml). This suggests that MMP-3 levels in GCF increases proportionally with the progression of periodontal disease and decreases after treatment. Lowest mean TIMP-1 concentrations in GCF were obtained for Group-II (1.592 ng/ml), while the highest concentrations were seen in Group-I (8.78 ng/ml) and Group-III (6.40 ng/ml). This suggests that TIMP-1 levels in GCF decreases proportionally with progression of periodontal disease and increases after treatment. Conclusion: There is a substantial increase in the concentrations of MMP-3 and decrease in TIMP-1 as periodontal disease progress. Since MMP-3 and TIMP-1 levels in GCF are positively correlated with gingival index, probing pocket depth, and clinical attachment loss, MMP-3, and TIMP-1 may be considered as a Novel Biomarkers in periodontal disease. However, controlled, longitudinal studies are needed to confirm this possibility.

Kumar, P. Mohan; Reddy, N. Ravindra; Deepa, A.; Babu, D. S. Madhu; Kumar, A. Kishore; Chavan, Vinay



Clinico-radiological profile of indirect neural decompression using cage or auto graft as interbody construct in posterior lumbar interbody fusion in spondylolisthesis: Which is better?  

PubMed Central

Study design: A prospective clinical study of posterior lumbar interbody fusion in grade I and II degenerative spondylolisthesis was conducted between Mar 2007 and Aug 2008. Purpose: The objective was to assess the clinicoradiological profile of structural v/s nonstructural graft on intervertebral disc height and its consequences on the low back pain (LBP) assessed by Visual analog score (VAS) score and oswestry disability index (ODI) . This study involved 28 patients. Inclusion criteria: Age of 30–70 years, symptomatic patient with disturbed Activities of daily living (ADL), single-level L4/L5 or L5/S1 grade I or grade II degenerative spondylolisthesis. Exclusion criteria: Patients with osteoporosis, recent spondylodiscitis, subchondral sclerosis, visual and cognitive impairment and all other types of spondylolisthesis. All the patients underwent short-segment posterior fixation using CD2 or M8 instrumentation, laminectomy discectomy, reduction and distraction of the involved vertebral space. In 53.5% (n = 15) of the patients, snugly fitted local bone chips were used while in 46.4% (n = 13) of the patients, cage was used. Among the cage group, titanium cage was used in nine (32.1%) and PEEK cages were used in four (14.2%) patients. In one patient, a unilateral PEEK cage was used. The mean follow-up period was 24 months. Among the 28 patients, 67.8% (n = 19) were females and 32.14% (n = 9) were males. 68.24% (n = 18) had L4/L5 and 35.71% (n = 10) had L5/S1 spondylolisthesis. 39.28% (n = 11) were of grade I and 60.71% (n = 17) were of grade II spondylolisthesis. Conclusions: There was a statistically significant correlation (P < 0.012 and P < 0.027) between the change in disc height achieved and the improvement in VAS score in both the graft group and the cage group. The increment in disc height and VAS score was significantly better in the cage group (2 mm ± SD vis-a-vis 7.2 [88%]) than the graft group (1.2 mm ± SD vis-a-vis 5 [62 %]).

Abdul, Q. R.; Qayum, M. S.; Saradhi, M. V.; Panigrahi, M. K.; Sreedhar, V.



Clinico-Pathological Features of Newcastle Disease in Japanese Quails (Coturnix coturnix japonica) Infected with Newcastle Disease Virus Kudu 113 Strain  

Microsoft Academic Search

3 Abstract: Experiments were performed to determine whether Japanese quails (Coturnix coturnix japonica) are susceptible to Newcastle disease virus (NDV) Kudu 113 strain. In the experimental trials, a total 119, six weeks old Japanese quails were administered varying doses of the virus, ranging from 0.1 ml to 0.3 ml intramuscularly (im) and per os (po). The uninfected control quails were

Sunday Blessing Oladele; Ishiaku Enoch; O. J. Ibu



Evaluation of immediately loaded dental implants bioactivated with platelet-rich plasma placed in the mandibular posterior region: A clinico-radiographic study  

PubMed Central

Background and Objectives: The purpose of the present study was to clinically and radiographically assess the soft and hard tissue changes around the immediately loaded single tooth implants bioactivated with platelet-rich plasma (PRP), placed in the mandibular posterior region. Materials and Methods: A total of 11 patients having single tooth edentulous space in the mandibular posterior region were selected. An endosseous implant was placed after clinical and radiographic examination in each selected site using single stage surgical approach. The patients were followed up at 3, 6, 9, and at 12 months of post implant insertion. The patients were subjected to recording of clinical parameters like modified plaque index, modified gingival index, probing depth, and clinical implant mobility scale. Radiographs made at different intervals were subjected to assessment of bone level mesial and distal to each implant using computer assisted image analysis. Results: Scores for clinical parameters were minimal and comparable. The probing depth around the implant was measured during the follow-up period and the changes observed were statistically non-significant. None of the implants were clinically mobile during the follow-up period. Radiographically, the peri-implant bone resorption both on mesial and distal sides was within normal limit after one year of immediate loading. Finally, the overall success rate for the immediately loaded bioactivated implant placed in the mandibular posterior region was recorded as 100%. Interpretation and Conclusion: The use of platelet-rich plasma may lead to improved early bone apposition around the implant; and thus, results in increased rate of osseointegration. Single stage implant procedure with the adjunctive use of PRP enhances the ability of peri-implant healing tissue to create favorable soft and hard tissue relationships. It also gives the added advantage of psychological boost for the patient by getting fixed replacement of tooth within a short time period.

Anand, Ullas; Mehta, D. S.



A multi-centre clinico-genetic analysis of the VPS35 gene in Parkinson disease indicates reduced penetrance for disease-associated variants  

PubMed Central

Background Two recent studies identified a mutation (p.Asp620Asn) in the vacuolar protein sorting 35 gene as a cause for an autosomal dominant form of Parkinson disease . Although additional missense variants were described, their pathogenic role yet remains inconclusive. Methods and results We performed the largest multi-center study to ascertain the frequency and pathogenicity of the reported vacuolar protein sorting 35 gene variants in more than 15,000 individuals worldwide. p.Asp620Asn was detected in 5 familial and 2 sporadic PD cases and not in healthy controls, p.Leu774Met in 6 cases and 1 control, p.Gly51Ser in 3 cases and 2 controls. Overall analyses did not reveal any significant increased risk for p.Leu774Met and p.Gly51Ser in our cohort. Conclusions Our study apart from identifying the p.Asp620Asn variant in familial cases also identified it in idiopathic Parkinson disease cases, and thus provides genetic evidence for a role of p.Asp620Asn in Parkinson disease in different populations worldwide.

Sharma, Manu; Ioannidis, John P A; Aasly, Jan O; Annesi, Grazia; Brice, Alexis; Bertram, Lars; Bozi, Maria; Barcikowska, Maria; Crosiers, David; Clarke, Carl E; Facheris, Maurizio F; Farrer, Matthew; Garraux, Gaetan; Gispert, Suzana; Auburger, Georg; Vilarino-Guell, Carles; Hadjigeorgiou, Georgios M; Hicks, Andrew A; Hattori, Nobutaka; Jeon, Beom S; Jamrozik, Zygmunt; Krygowska-Wajs, Anna; Lesage, Suzanne; Lill, Christina M; Lin, Juei-Jueng; Lynch, Timothy; Lichtner, Peter; Lang, Anthony E; Libioulle, Cecile; Murata, Miho; Mok, Vincent; Jasinska-Myga, Barbara; Mellick, George D; Morrison, Karen E; Meitnger, Thomas; Zimprich, Alexander; Opala, Grzegorz; Pramstaller, Peter P; Pichler, Irene; Park, Sung Sup; Quattrone, Aldo; Rogaeva, Ekaterina; Ross, Owen A.; Stefanis, Leonidas; Stockton, Joanne D; Satake, Wataru; Silburn, Peter A; Strom, Tim M; Theuns, Jessie; Tan, Eng- King; Toda, Tatsushi; Tomiyama, Hiroyuki; Uitti, Ryan J; Van Broeckhoven, Christine; Wirdefeldt, Karin; Wszolek, Zbigniew; Xiromerisiou, Georgia; Yomono, Harumi S; Yueh, Kuo-Chu; Zhao, Yi; Gasser, Thomas; Maraganore, Demetrius; Kruger, Rejko



Correlation of vascular endothelial growth factor expression with fibroblast growth factor-8 expression and clinico-pathologic parameters in human prostate cancer  

PubMed Central

Vascular endothelial growth factor (VEGF) mediates neo-angiogenesis during tumour progression and is known to cooperate with the fibroblast growth factor (FGF) system to facilitate angiogenesis in a synergistic manner. In view of this, we have investigated VEGF expression in 67 cases of prostate cancer previously characterized for fibroblast growth factor-8 (FGF-8) expression. Cytoplasmic VEGF staining was detected in malignant cells in 45 out of 67 cases. Cytoplasmic staining was found in adjacent stromal cells in 32 cases, being particularly strong around nests of invasive tumour. Positive VEGF immunoreactivity in benign glands was restricted to basal epithelium. A significant association was observed between tumour VEGF and FGF-8 expression (P = 0.004). We identified increased VEGF immunoreactivity in both malignant epithelium and adjacent stroma and both were found to be significantly associated with high tumour stage (P = 0.0047 and P = 0.0002, respectively). VEGF expression also correlated with increased serum PSA levels (P = 0.01). Among positively stained tumours, VEGF expression showed a significant association with Gleason score (P = 0.04). Cases showing positive VEGF immunoreactivity in the stroma had a significantly reduced survival rate compared to those with negative staining (P = 0.037). Cases with tumours expressing both FGF-8 in the malignant epithelium and VEGF in the adjacent stroma had a significantly worse survival rate than those with tumours negative for both, or only expressing one of the two growth factors (P = 0.029). Cox multivariate regression analysis of survival demonstrated that stromal VEGF and tumour stage were the most significant independent predictors of survival. In conclusion, we report for the first time a correlation of both tumour and stromal VEGF expression in prostate cancer with clinical parameters as well as its correlation to FGF-8 expression. © 2001 Cancer Research Campaign

West, A F; O'Donnell, M; Charlton, R G; Neal, D E; Leung, H Y




Microsoft Academic Search

SUMMARY The authors analize the clinical and X-ray findings observed in a group of 52 patients with confirmed psoriatic arthritis. No significant correlation was detected joint involvement and duration of psoriatic arthritis. The so called typical lesions (onicopathy, erosions of DIP, opera glass deformities) were infrequent, while polyarthritis resembling rheumatoid arthritis was present in the majority of patients. The number




[Clinico-psychological mechanisms of compensation for disorders of brain activities in patients with traumatic lesions of the polar-basal sections of the frontal lobes].  


Twenty-five patients were subjected to surgical ablations of contused or crushed polar-basal regions of frontal lobes. Two groups were singled out: 1, compensated; and 2, subcompensated. "Lobar syndrome" which includes motor disorders and impaired psychic selectivity, planning, regulation and control of psychic activity and behavior, was to a several extent characteristic of all the patients. Posttraumatic disorders were compensated in group 1 due to a lack in complications and high intellectual level of the patients, both allowing to compensate the disorders in voluntary regulation of psychic activity and behavior. PMID:3245374

Niagu, A I; Privalova, N N



[Comparative study of parenteral and oral immunization to influenza in a large clinical trial. 1. Results of clinico-epidemiologic studies].  


360 volunteers were recruited for the investigation from a homologous collective. 174 were immunized parenterally with "Influmun" from SSW Dresden, GDR. 176 volunteers were immunized twice orally with an interval of 60 days with an influenza vaccine inactivated by x-ray using enteric-coated capsules. In an interval of six months ARI-symptoms were investigated. Between 13th and 17th week 1988 an increased ARI-morbidity in the Greifswald-region was observed in which influenza A viruses were involved. In comparison with 312 non-immunized persons of the same age, sex and living area the immunized volunteers of the two groups showed 83.4% less sickness days. 30 persons of the non-immunized group got ill for totally 217 days, whereas only nine persons of the two immunized groups were put on the sicklist for totally 36 days. No significant differences concerning the occurrence and duration of acute respiratory infections (ARI) between the two differently immunized groups could be observed. PMID:2264362

Tischner, H; Popp, M; Herrmann, H; Finke, E J; Totzke, O; Nordheim, W; Bräuniger, S; Werchan, D; Luther, P; Dittmann, S



An analysis from clinico-epidemiological data of the principal adverse events from the COX2 selective NSAID, nimesulide, with particular reference to hepatic injury  

Microsoft Academic Search

The safety of the cyclo-oxygenase-2 (COX-2) selective NSAID, nimesulide, has been evaluated from information (a) in clinical\\u000a trials in osteoarthritis that have been performed in Europe as well as in earlier pilot studies that were performed in patients\\u000a with rheumatoid arthritis in the USA, and (b) in post-marketing studies (PMS) that have been performed by the manufacturer\\u000a since the introduction

K. D. Rainsford



Malignant lymphoma of the gastrointestinal tract and mesentery. A clinico-pathologic study of the significance of histologic classification. NHL Study Group of the Comprehensive Cancer Center West.  

PubMed Central

A series of 92 malignant lymphomas of the gastrointestinal tract and mesentery obtained from a population-based registry was studied to assess whether the newly defined concept of mucosa-associated lymphoma has clinical relevance. The cases were grouped according to localization; gastric, intestinal, and mesenteric lymphoma. All cases were reviewed histologically, graded according to the Working Formulation, and reclassified according to the Kiel classification, which was modified to include the categories low- and high-grade mucosa-associated lymphoma. Clinical data, as well as staging and follow-up data, were related to both the original diagnosis and the diagnosis after reclassification. The results showed that the distribution of the types of lymphoma is related to site: centroblastic lymphoma was predominant in the stomach, lymphoblastic in the bowel, and follicular centroblastic-centrocytic in the mesentery. Gastrointestinal lymphoma was disseminated in approximately 50% of the patients at presentation. Survival analysis revealed that classification according to the original Kiel classification and grading according to the Working Formulation provided important prognostic information, whereas introduction of mucosa-associated lymphoma as an entity did not. It was concluded that modification of current classifications to include a separate category for mucosa-associated lymphoma is not useful. Images Figure 1 Figure 2 Figure 3 Figure 4 Figure 5

van Krieken, J. H.; Otter, R.; Hermans, J.; van Groningen, K.; Spaander, P. J.; van de Sandt, M. M.; Keuning, J. F.; Kluin, P. M.



The clinician's role in the diagnosis of breast disease  

PubMed Central

Until 20 or 30 years ago, the diagnosis and treatment of breast disease was managed exclusively by the surgeon. This situation has changed to some extent as a result of recent technological advances, and clinicians’ contributions to the diagnostic work-up and/or treatment of these cases can begin at any time. If they are the first physician to see the patient after the examination and formulation of a diagnostic hypothesis, they will almost always have to order a panel of imaging/instrumental examinations that is appropriate for the type of lesion suspected, the patient’s age, and other factors; if they intervene at the end of the diagnostic work-up, it will be their job to arrive at a conclusion based on all of the data collected. The clinical examination includes various steps – history taking and inspection and palpation of the breasts – each of which is essential and requires the use of appropriate methods and techniques. The diagnostic capacity of the examination will depend largely on the consistency of the breasts, but it is influenced even more strongly by the doctor–patient relationship. Physicians must know their patient well, listen to and understand what she is saying, explain their own findings and verify that the explanations have been understood, and they must be convincing. Clinicians must also be able to assess the results of imaging studies (rather than relying solely on the radiologist’s report), and this requires interaction with other specialists. The days are over when a clinician or radiologist or sonographer worked alone, certain that his/her examination method was sufficient in itself: today, teamwork is essential. But this also means that each member of the team must be extremely competent in his/her own sector and be aware of the other team members’ limitations and expectations. The clinical examination remains central to the process since it is the basis for selecting appropriate treatment. Sommario Da quando si conosce la patologia mammaria la diagnosi e la terapia di tale patologia sono state a totale appannaggio del chirurgo, situazione che è proseguita fino a qualche decennio fa. Il recente progresso tecnologico ha modificato, in parte, questa situazione e il clinico può entrare nel percorso diagnostico o terapeutico in qualsiasi momento. Se è il primo coinvolto, dopo l’esame e dopo un’ipotesi diagnostica, dovrà, quasi sempre, orientarsi verso indagini strumentali in relazione al sospetto, all’età della paziente ecc., se è l’ultimo anello deve arrivare a una conclusione mettendo insieme tutte le informazioni. L’esame clinico è composto di varie fasi: anamnesi, ispezione, palpazione, ognuna essenziale. Ogni singola fase va affrontata con metodo e tecnica appropriata. La capacità diagnostica dell’esame clinico è influenzata dalla costituzione della mammella, ma ancor di più è condizionata da uno stretto rapporto tra paziente e medico che deve conoscere molto la paziente che gli sta davanti e che non solo deve “visitare”, ma capire, spiegare, accertarsi che si abbia capito, convincere. È inoltre indispensabile che il clinico sia in grado di esaminare le indagini strumentali e non limitarsi a leggere i referti, quindi interagire con gli altri specialisti. L’epoca del clinico o del radiologo o dell’ecografista che lavora da solo credendo che il proprio esame sia sufficiente o sganciato da altri contesti è finita da tempo, tutti hanno bisogno di tutti. È però vero che ciascuno deve essere estremamente competente nel suo settore e deve conoscere i limiti e le aspettative di chi collabora in altre specialità, come rimane valida la regola che la clinica resta comunque il momento centrale, non fosse altro perché poi deve affrontare la terapia.

Poma, S.; Longo, A.



Revision curricular a partir de un analisis comparativo de las discrepancias en los curriculos de una escuela de optometria en Puerto Rico con las competencias requeridas para las agencias de revalida y acreditacion 2004  

NASA Astrophysics Data System (ADS)

El proposito de esta investigacion, un estudio cualitativo de caso, fue comparar y contrastar el curriculo vigente de la Escuela de Optometria de la UIAPR con las competencias y estandares requeridos por las agencias de acreditacion y de revalida. Con este proposito, decidimos realizar una revision y un analisis de documentos: el prontuario de cada uno de los cursos de los curriculos implantados en el 1993 y en el 2001; las competencias y estandares establecidos por las agencias de revalida y de acreditacion; y las estadisticas en las que se analiza el porcentaje de estudiantes que aprueban cada una de las partes de los examenes de revalida entre el 1998 al 2003. Se realizaron entrevistas dirigidas para dar apoyo y complementar la revision y el analisis de estos documentos. Los participantes de las entrevistas fueron tres estudiantes de la clase de optometria del 2004 (ultima clase del curriculo del 1993); tres estudiantes de la clase de optometria del 2005 (primera clase graduanda del curriculo vigente) y tres profesores y/o directores de los Departamentos de Ciencias Basicas, Ciencias Clinicas y Cuidado al Paciente. Esta investigacion se enmarco en el modelo de evaluacion curricular de discrepancia de Malcolm Provus y en el modelo de desarrollo basado en competencias. Uno de los hallazgos mas importantes del estudio es que los cambios que se implantaron al curriculo del 2001 no han logrado que los estudiantes mejoren su ejecucion en los examenes de revalida. Por otro lado, se encontro que el curriculo vigente atiende completamente los estandares de la practica de Optometria, pero no las competencias. Esta informacion fue validada mediante el uso de una tabla de cotejo para el analisis de los cursos y de la informacion obtenida de las entrevistas. El estudio determina y concluye que existen discrepancias entre los prontuarios de los cursos del curriculo y las competencias requeridas por la agencia de revalida. Segundo, que el Departamento de Ciencias Basicas es el que presenta mas deficiencias en el desarrollo de las competencias. El investigador recomienda disenar e implantar un curriculo basado en competencias y proveer formacion en didactica y procesos de aprendizaje a los profesores.

Rivera Pacheco, Andres


Synthesis, characterization, and glutathionylation of cobalamin model complexes [Co(N4PyCO2Me)Cl]Cl2 and [Co(Bn-CDPy3)Cl]Cl2.  


Synthetic Co(III) complexes containing N5 donor sets undergo glutathionylation to generate biomimetic species of glutathionylcobalamin (GSCbl), an important form of cobalamin (Cbl) found in nature. For this study, a new Co(III) complex was synthesized derived from the polypyridyl pentadentate N5 ligand N4PyCO(2)Me (1). The compound [Co(N4PyCO(2)Me)Cl]Cl(2) (3) was characterized by X-ray crystallography, UV-vis, IR, (1)H NMR, and (13)C NMR spectroscopies and mass spectrometry (HRMS). Reaction of 3 with glutathione (GSH) in H(2)O generates the biomimetic species [Co(N4PyCO(2)Me)(SG)](2+) (5), which was generated in situ and characterized by UV-vis and (1)H NMR spectroscopies and HRMS. (1)H NMR and UV-vis spectroscopic data are consistent with ligation of the cysteine thiolate of GSH to the Co(III) center of 5, as occurs in GSCbl. Kinetic analysis indicated that the substitution of chloride by GS(-) occurs by a second-order process [k(1) = (10.1 ± 0.7) × 10(-2) M(-1) s(-1)]. The observed equilibrium constant for formation of 5 (K(obs) = 870 ± 50 M(-1)) is about 3 orders of magnitude smaller than for GSCbl. Reaction of the Co(III) complex [Co(Bn-CDPy3)Cl]Cl(2) (4) with GSH generates glutathionylated species [Co(Bn-CDPy3)(GS)](2+) (6), analogous to 5. Glutathionylation of 4 occurs at a similar rate [k(2) = (8.4 ± 0.5) × 10(-2) M(-1) s(-1)], and the observed equilibrium constant (K(obs) = 740 ± 47 M(-1)) is slightly smaller than for 5. Glutathionylation showed a significant pH dependence, where rates increased with pH. Taken together, these results suggest that glutathionylation is a general reaction for Co(III) complexes related to Cbl. PMID:22316335

Prakash, Jai; Kodanko, Jeremy J



Síndrome de Stevens-Johnson y necrólisis epidérmica tóxica por profilaxis con TARGA en el Hospital Nacional Almanzor Aguinaga Asenjo, Lambayeque,Perú Stevens Johnson syndrome and toxic epidermal necrolysis induced by HAART prophylaxis in the National Hospital Almanzor Aguinaga Asenjo, Lambayeque, Perú  

Microsoft Academic Search

RESUMEN Síndrome de Stevens-Johnson (SSJ) y necrólisis epidérmica tóxica (NET) son reacciones inflamatorias agudas originadas por hipersensibilidad (reacción inmunológica), que incluye piel y membranas mucosas. Se presenta un caso de reacción adversa medicamentosa en un paciente varón de 25 años, que recibió profilaxis con Terapia Antiretroviral de Gran Actividad. Presentó exantema, que progresa a SSJ y evoluciona a NET. Permaneció

Victor A. Soto Cáceres; Rosa E. Rodríguez Barboza



Has allogeneic stem cell cryopreservation been given the 'cold shoulder'? An analysis of the pros and cons of using frozen versus fresh stem cell products in allogeneic stem cell transplantation.  


Donor stem cells for allogeneic transplant traditionally are collected and transfused 'fresh' into the recipient on the day of transplant; alternatively such cells can be collected in advance and cryopreserved until needed. Most centers favor the former approach based on theoretical concerns that cryopreservation and thawing may worsen clinical outcomes. Limited published data from single institution retrospective studies show no significant impairment of engraftment or reduced day 100 survival for cryopreserved bone marrow recipients. There are no reported outcomes for recipients of cryopreserved peripheral blood allografts. Use of cryopreserved stem cells is associated with a higher incidence of adverse events (transfusion reactions, bacterial graft contamination and collection of grafts which are not utilized). Conversely, use of cryopreserved grafts introduces a greater flexibility into a stressed healthcare system and results in a more streamlined experience for the donor. Some data suggest that transplantation with a cryopreserved product may lower the incidence of acute graft-versus-host disease. We compare the pros and cons of using 'fresh' versus cryopreserved stem cell products for allogeneic transplantation and suggest that the current standard of using 'fresh' products may not be warranted. We also suggest future areas of exploration to better elucidate this issue. PMID:16892075

Frey, N V; Lazarus, H M; Goldstein, S C



Brewers' spent grain (BSG) protein hydrolysates decrease hydrogen peroxide (H2O2)-induced oxidative stress and concanavalin-A (con-A) stimulated IFN-? production in cell culture.  


The present study investigated the bioactivity of protein hydrolysates and fractionated hydrolysates prepared from brewers' spent grain (BSG) using proteases, including Alcalase 2.4L, Flavourzyme and Corolase PP. Hydrolysates were designated K-Y, including fractionated hydrolysates with molecular weight (m.w.) < 3, <5 and >5 kDa. Where computable, IC50 values were lower in U937 (1.38-9.78%) than Jurkat T cells (1.15-13.82%). Hydrolysates L, Q and R and fractionated hydrolysates of U and W (<3, <5, >5 kDa) significantly (P < 0.01) protected against hydrogen peroxide (H2O2)-induced reduction of superoxide dismutase (SOD) activity. A fractionated hydrolysate of W (<5 kDa) protected against H2O2-induced DNA damage, P < 0.01. Hydrolysates K, N, P, U, U > 5 kDa, V, V > 5 kDa, W, W > 5 kDa significantly (P < 0.05) reduced a concanavlin-A (con-A) stimulated production of interferon-? (IFN-?). In conclusion, BSG protein hydrolysates demonstrate bioactivity in vitro; lower m.w. hydrolysates (<3, <5 kDa) show greatest antioxidant activity and unfractionated or higher m.w. hydrolysates (>5 kDa) possess anti-inflammatory effects. PMID:24113874

McCarthy, Aoife L; O'Callaghan, Yvonne C; Connolly, Alan; Piggott, Charles O; Fitzgerald, Richard J; O'Brien, Nora M



The office surgical suite: pros and cons.  


Today interest and enthusiasm regarding facial plastic surgery is burgeoning. Office surgery provides a new, more expedient, comfortable method of delivery of health care while directly responding to the growing concern among the public and government for improved cost containment of medical services. Awareness of improved surgical techniques and facilities will help to ensure tomorrow's continued growth and satisfaction for both the surgeon and his patient. PMID:7393580

Simons, R L



Pros and cons of subpectoral implantation.  


At the present time, there is no universally accepted surgical technique or prosthesis for augmenting breast volume. Each surgeon has to choose with regard to shape, consistency, and volume, according to his own conviction and respecting his patient's priorities. These priorities will vary with age, profession, sexual habits, and marital and social status. In order to get the best possible results, the plastic surgeon should be adept at alternative methods and should not be restricted to one technique or one prosthesis. Patients vary considerably so our methods should be diversified. Our subpectoral implantations have given us better results than our retroglandular ones, which have been performed during the same period of time and with the same prosthesis. Consequently, retropectoral implantation is still our preferred procedure. We think that this technique, with its proper indications, deserves wider application. PMID:1261186

Papillon, J



La relazione analitica con i pazienti schizoidi  

Microsoft Academic Search

da molti anni che mi dedico a mettere in luce il funzionamento dei pazienti schizoidi. Non già a comprendere il Disturbo Schizoide di Personalità descritto in tassonomie psichiatriche come il DSM, ma la let- tura psicoanalitica fenomenologica delle problematiche schizoidi. Ho sempre avuto un grande interesse ad esplorare le differenze individuali più che a definire ciò che è o non

Nancy McWilliams


Análisis de Variabilidad con Modelos de Objetivos  

Microsoft Academic Search

Dentro del campo de la variabilidad, o la habilidad de cambio o personalización de un sistema, no es común que dicha variabilidad se tenga en cuenta en la definición de requisitos. En las propuestas donde si se contemplan se utilizan directamente features, aunque no son una técnica de elicitación de requisitos, sino que más bien están a medio camino entre

Bruno González-Baixauli; Miguel A. Laguna; Sampaio do Prado



Pros and cons of apartment complex submetering  

Microsoft Academic Search

Mastermetering was popular when energy costs were low, but landlords can no longer raise rents fast enough to keep up with rising utility costs. Individual metering and submetering are a growing trend in Texas in order to regulate cash flow and keep rents competitive. Individual metering encourages conservation, but reduces the owner's incentives to improve building efficiency. Owners may not

G. Reichelt; J. Jones



Tratamiento nutricional del niño con trastorno neuromotor  

Microsoft Academic Search

The risk of suffering malnutrition is very high in children and adolescents who suffer a certain type of neuromotor pathology (NP) due to different factors that occur in them: motor coordination disorders in the different stages of deglutition, gastroesophageal reflux, oesophagitis, gastritis, gastrocolic reflex alteration, constipation, anorexia, etc. These disorders alter the desirable proportionality between the amount of food given

Isabel Polanco Allué



Cálculos ab initio con correlación electrónica  

Microsoft Academic Search

Estamos entrando en una era donde la ortogonalidad entre las investigaciones de carácter experimental y de naturaleza teórica se irá difuminando progresivamente y la problemática a resolver quedará en escena como el único actor principal de la obra. Como premisa para una cooperación teórico-experimental de igual a igual, la metodología químico-cuántica utilizada debe ser capaz de ofrecer resultados de carácter

M. Merchán Bonete



Polarimetría de estrellas con discos de ``escombros''  

NASA Astrophysics Data System (ADS)

We present optical polarimetric measurements of a set of ˜100 solar-type stars with and without debris disks. The selection of these objects were based on the presence of excesses in the spectral energy distributions. This sample is complemented with a group of stars from the northern hemisphere with similar characteristics. A statistical comparison of the stars with and without disk shows no significant differences in the observed polarizations. However, we identified a subset of objects (<10 % of the whole sample) with polarizations above the median that not follow the Law of Serkowsky. These polarizations might be due to the presence of disks. FULL TEXT IN SPANISH

García, L.; Gómez, M.


Dismenorrea por útero unicorne con cuerno rudimentario  

Microsoft Academic Search

Dysmenorrhea is highly frequent in adolescents and young women, affecting 40-50% of this population to some degree.Unicornuate uterus with rudimentary horn and functional endometrium can cause dysmenorrhea due to the distension produced by blood in a closed cavity and the consequent development of hematometra, hematosalpinx, and retrograde menstruation. Treatment is necessarily surgical and the recommended intervention is excision of the

Borja Rivero; Iurdana Aizpitarte; Ainhoa Elvira; José Ramón Becerro



Alteraciones dermatológicas en pacientes con anemias carenciales  

Microsoft Academic Search

Objectives: To determine the frequency of anemia-related dermatological abnormalities and severity. Materials and Methods: A sample of 100 subjects older than 18 years with a diagnosis of nutritional anemia who were admitted at 2 de Mayo Hospital between January and November, 2004 was studied. In each subject we measured total CBC and serum iron, ferritin, folate, and cobalamin levels. Results:

Oscar Ruiz; Luz Bardales; David Díaz; Carlos Galarza; Carlos Delgado; Oscar Castillo; Manuela Marangoni; Carlos Montenegro



The Pros and Cons of Petroleum Agreements.  

ERIC Educational Resources Information Center

A mineral agreements expert discusses the options open to tribes, from the most standard lease form to arrangements as yet untried by Indian Nations. Discussion covers 18 basic provisions for inclusion in agreements, tax considerations, and basic forms of petroleum agreements (leases, joint ventures, production sharing, and service contracts).…

Lipton, Charles J.



Localización de Insulinoma Pancreático con Ultrasonografía Laparoscópica  

Microsoft Academic Search

The case of a 51-year-old woman with a clinical history of hipoglicemia caused by a presumed pancreatic insulinoma is reported. Laboratory tests pointed out for a insulinoma, but imaginologic studies could not locate the tumor. Under this circumstances, the patient was laparoscopically approached. By means of the ultrasononography device the tumor was located at the uncinate process of the pancreas

Francisco Berrospi Espinoza; Juan Celis Zapata; Eloy Ruiz Figueroa; Iván Chavez


Stepwise versus Hierarchical Regression: Pros and Cons  

ERIC Educational Resources Information Center

Multiple regression is commonly used in social and behavioral data analysis. In multiple regression contexts, researchers are very often interested in determining the "best" predictors in the analysis. This focus may stem from a need to identify those predictors that are supportive of theory. Alternatively, the researcher may simply be interested…

Lewis, Mitzi



Vencemos Con Libros Y La Lengua.  

National Technical Information Service (NTIS)

The city of Richmond, California has many residents who read and speak only Spanish, and many other Chicanos and Latin Americans who are interested in their heritage. The Service Center Branch of the public library has a collection of books, magazines, an...

D. F. Duran



Nanoparticles: Health Effects--Pros and Cons  

PubMed Central

With the advent of nanotechnology, the prospects for using engineered nanomaterials with diameters of < 100 nm in industrial applications, medical imaging, disease diagnoses, drug delivery, cancer treatment, gene therapy, and other areas have progressed rapidly. The potential for nanoparticles (NPs) in these areas is infinite, with novel new applications constantly being explored. The possible toxic health effects of these NPs associated with human exposure are unknown. Many fine particles generally considered “nuisance dusts” are likely to acquire unique surface properties when engineered to nanosize and may exhibit toxic biological effects. Consequently, the nuisance dust may be transported to distant sites and could induce adverse health effects. In addition the beneficial uses of NPs in drug delivery, cancer treatment, and gene therapy may cause unintentional human exposure. Because of our lack of knowledge about the health effects associated with NP exposure, we have an ethical duty to take precautionary measures regarding their use. In this review we highlight the possible toxic human health effects that can result from exposure to ultrafine particles (UFPs) generated by anthropogenic activities and their cardiopulmonary outcomes. The comparability of engineered NPs to UFPs suggests that the human health effects are likely to be similar. Therefore, it is prudent to elucidate their toxicologic effect to minimize occupational and environmental exposure. Highlighting the human health outcomes caused by UFPs is not intended to give a lesser importance to either the unprecedented technologic and industrial rewards of the nanotechnology or their beneficial human uses.

Gwinn, Maureen R.; Vallyathan, Val



Roofing with Urethane: Pro and Con.  

ERIC Educational Resources Information Center

|Gerald Scott's favorable evaluation of the foamed polyurethane roofing system is based on experiences with 55 buildings at Texas A & M. Michael Kinzer, an architect at Colorado State University, disagrees and claims that the system is difficult to install and maintain, and the cost prohibitive. (MLF)|

Kinzer, Michael; Scott, Gerald P.E.



Planetas extrasolares con pequeño semieje orbital  

NASA Astrophysics Data System (ADS)

The discovery of extra-solar planets, first surrounding a pulsar (PSR1257+12, Malhotra et al 1992) and then main-sequence stars similar to our sun, ( has opened a new field of study inside the dynamic of planetary systems. Although the information we have of these objects is determined by the own limitations of the detection methods that are used, important differences between these systems and the Solar System were observed. The mass of these planets are, in general, bigger than Jupiter, the measured semimayor axes have a low limit of 0.04 AU, the ten part of Mercury semimayor axe. Further, the excentricities take different values from almost 0 to 0.93, in contrast to our system where the planetary orbits are approximately circular. Among the extra solar planets detected until August 2002, it is possible to observe a deficiency of massive planets (Mp sin I < 3.5 Mj) near the primary star, i.e. semimayor axe below 0.1 AU, with excentricity below 0.2. The goal of this work is to attempt an explanation of these cases by an eliptic planar model in which two point planets interac gravitationaly. The motion equations are analized for different initial conditions by using numerical methods. The motion equations were stated and several pairs of particles were generated by varying the relative masses and the orbital elements. To integrate the equations the Bulirsh - Stoer code was used, with a 10-12 accuracy. As a control variable of the results the calculus of energy was used. The total span of integrations was 106 years. The outputs of the numerical simulations show several dynamic behaviors for the particles: - Lower mass escapes to the outside of the system - Stability in both bodies - Less massive planet fall to the primary star Moreover, by comparing the results obtained for objets with identical initial conditions in their orbital parameters, but with different relations of mass, it is possible to distinguish two types of behaviours: - during the integration time there is dynamical estability if both masses are below 3.5Mj. - the less massive planet fall to the star if the other mass is about 10Mj. in this case the major body increase his semimajor axe in order to preserve the constancy of the angular moment of the total system. The simulations performed have shown results with a high dependence of the values of the initial conditions and the masses of the planets considered.

Giuliodori, D.; Fernández, S.


Coal gasification\\/pros and cons  

Microsoft Academic Search

About 80% of total remaining U.S. fossil fuel resource is in the form of coal. World oil production is expected to peak not later than 2000; a precipitous rise in world oil prices can be expected. Currently SNG from coal at a cost of $3.50 to $4.50\\/million Btu, is equivalent to oil at $15 to $25\\/bbl. Low-Btu gas from coal



The pros and cons of phytoestrogens  

PubMed Central

Phytoestrogens are plant derived compounds found in a wide variety of foods, most notably soy. A litany of health benefits including a lowered risk of osteoporosis, heart disease, breast cancer, and menopausal symptoms, are frequently attributed to phytoestrogens but many are also considered endocrine disruptors, indicating that they have the potential to cause adverse health effects as well. Consequently, the question of whether or not phytoestrogens are beneficial or harmful to human health remains unresolved. The answer is likely complex and may depend on age, health status, and even the presence or absence of specific gut microflora. Clarity on this issue is needed because global consumption is rapidly increasing. Phytoestrogens are present in numerous dietary supplements and widely marketed as a natural alternative to estrogen replacement therapy. Soy infant formula now constitutes up to a third of the US market, and soy protein is now added to many processed foods. As weak estrogen agonists/antagonists with molecular and cellular properties similar to synthetic endocrine disruptors such as Bisphenol A (BPA), the phytoestrogens provide a useful model to comprehensively investigate the biological impact of endocrine disruptors in general. This review weighs the evidence for and against the purported health benefits and adverse effects of phytoestrogens.

Patisaul, Heather B.; Jefferson, Wendy