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PubMed Central

Objective: Cystic ameloblastoma represent 10-15% of all intra osseous ameloblastomas and appear to be less aggressive than the solid ameloblastomas. The aim of this study was to examine the clinico-pathologic characteristics of cystic ameloblastomas seen at a tertiary health care centre. Materials: All cases diagnosed as cystic ameloblastoma in the Oral Pathology Department of University College Hospital, Ibadan over a 10 year period were investigated for age, gender, location of lesion, treatment, and follow-up. The cases were classified as luminal, intraluminal or mural, based on Ackermann classification. The data was entered into the statistical package for the social sciences version 18 (SPSS 18) and results expressed as percentages. Results: Fifteen cystic ameloblastomas, representing 14.3% of a total of 105 ameloblastoma cases were seen. The mean age was 28.9(±14.5) years with 73.4% occurring in the second and third decades. The male:female ratio was 2:3. Fourteen (93.3%) of the lesions were in the mandible while only one (6.7%) was in the maxilla. The mural variant was the most common histological variant with 6(40%) cases while the luminal and intra-luminal had 4(26.7%) and 5(33.3%) respectively. The multilocular radiologic appearance was more common than the unilocular in this study (ratio 8:4). Cystic ameloblastoma with multilocular appearance occurred in a higher age group (mean age 31yrs) when compared with the unilocular type which had a mean age of 16.3years. Conclusion: This study shows similar findings with previous studies but shows a higher multilocular radiological appearance as compared to unilocular variant and no case of recurrence.

Lawal, A.O.; Adisa, A.O.; Olajide, M.A.



Clinico-Pathological Correlations of the Most Common Neurodegenerative Dementias  

PubMed Central

Neurodegenerative dementias are a group of neurological disorders characterized by deterioration in several cognitive domains in which there is selective and progressive loss of specific populations of neurons. The precise neurobiological basis for the different neurodegenerative dementias remains unknown. It is expected that different pathologies reflect different mechanisms, at least early in the neurodegeneration process. The next decades promise treatments directed to causes and mechanisms, bringing an outstanding challenge to clinicians due to heterogeneous clinical presentations with the same molecular pathology. The purpose of this brief review is to describe the key neuropathological features of the most common neurodegenerative dementias (Alzheimer disease, dementia with Lewy bodies and Parkinson’s disease dementia, and frontotemporal lobar degeneration) and the relationship with the clinical syndromes described in clinico-pathological studies. We expect this overview contributes for the understanding of this broad topic integrating the two ends of the spectrum: clinical and pathological. PMID:22557993

Taipa, Ricardo; Pinho, Joao; Melo-Pires, Manuel



[Clinico-roentgenologic diagnosis of spinal arachnoiditis and epiduritis].  


The clinico-radiological picture of spinal arachnoiditis and epiduritis was studied in 135 patients. The disorders were expressed in the form of radicular pain, paresthesia, hyperesthesia, pareses, paralyses and pelvic disturbances. The most informative of radiological methods were pneumomyelography, myelography with myodile, sacral and transdural epidurography. Contrast radiological examinations of the membranous spaces of the spinal cord make it possible to determine the localization, severity and nature of pathological changes. Spinal arachnoiditis and epiduritis are associated with non-filling or non-uniform filling of the membranous spaces, their narrowing and deformation, non-filling and deformation of radicular pockets. The diagnosis is made by correlating clinical, laboratory and radiological findings. PMID:4090836

Sipukhin, Ia M; Galin, Iu M; Khmaruk, L P



A clinico-mycological study of dermatophytoses in goa, India.  


The study was a clinico-mycological approach to find out the various clinical types of dermatophytoses and as well as the species of dermatophytes in Goa. Various socio-demographic and host factors were assessed to determine the predisposing factors for dermatophytoses. A detailed clinical history of the patients was recorded. Samples were collected aseptically in sterile black paper envelopes. The material was subjected to microscopy using potassium hydroxide mount. Culture was done by inoculating the material in Sabouraud's peptone glucose agar slants. Tinea corporis was found to be the most common clinical presentation (44.2 %). Among the dermatophytes, Trichophyton rubrum predominated (38.2 %), followed by Trichophyton mentagrophytes (27.2 %). Dermatophytoses was more common among the lower and upper lower strata of society. Majority of the patients were in the 21-40 years age group (62 %) with males predominating women in ratio 2.4:1. PMID:25163746

Maulingkar, Saleel V; Pinto, M J W; Rodrigues, S



Review of tumoral calcinosis: A rare clinico-pathological entity  

PubMed Central

Tumoral calcinosis (TC) has long been a controversial clinico-pathological entity. Its pathogenesis and genetic background have been gradually unravelled since its first description in 1943. According to the presence or absence of an underlying calcifying disease process, TC has been divided into primary and secondary varieties. Two subtypes of the primary variety exist; a hyper-phosphatemic type with familial basis represented by mutations in GalNAc transferase 3 gene (GALNT3), KLOTHO or Fibroblast growth factor 23 (FGF23) genes, and a normo-phosphatemic type with growing evidence of underlying familial base represented by mutation in SAMD9 gene. The secondary variety is mainly associated with chronic renal failure and the resulting secondary or tertiary hyperparathyroidism. Diagnosis of TC relies on typical radiographic features (on plain radiographs and computed tomography) and the biochemical profile. Magnetic resonance imaging can be done in difficult cases, and scintigraphy reflects the disease activity. Treatment is mainly surgical for the primary variety; however, a stage-oriented conservative approach using phosphate binders, phosphate restricted diets and acetazolamide should be considered before the surgical approach is pursued due to the high rate of recurrences and complications after surgical intervention. Medical treatment is the mainstay for treatment of the secondary variety, with failure warranting subtotal or total parathyroidectomy. Surgical intervention in these patients should be kept as a last resort. PMID:25232542

Fathi, Ibrahim; Sakr, Mahmoud



Clinico-pathological profile of 12 cases of chorangiosis.  


Chorangiosis is one of the vascular lesions that involves terminal chorionic villi. It is commonly associated with various feto-maternal conditions like pre-eclampsia, diabetes etc. However, the clinical significance of this pathological finding has not been studied extensively. The aim of this study was to identify the various conditions associated with chorangiosis and to determine its clinical significance. A retrospective study to identify the cases of placentas diagnosed with chorangiosis was carried out and the clinical and morphological details of these cases were reviewed. Immunostaining for CD34 and muscle-specific actin was also performed to confirm chorangiosis and to exclude chorangiomatosis. A total of 12 cases of chorangiosis were retrieved, most of them were of term gestation. Five of these 12 cases were associated with various maternal conditions including syphilis (2 cases) and single cases of pre-eclampsia, diabetes and jaundice. One case in each had abruptio placenta and non-immune hydrops. Of these 12 cases, seven were stillborn. Microscopically, all 12 cases showed extensive chorangiosis involving terminal villi. In addition, two cases showed focal infarction and one had extensive calcification. Immunostaining for CD34 confirmed increased number of capillaries while muscle-specific actin was negative, excluding chorangiomatosis. The clinico-pathological profile presented in this study suggests that chorangiosis has characteristic pathological features for its recognition and needs to be differentiated from similar conditions like chorangioma and chorangiomatosis. Also, chorangiosis has potential clinical significance and should be mentioned in the pathology report and the patient should be investigated for associated conditions like syphilis, pre-eclampsia, diabetes etc. PMID:16208478

Gupta, Ruchika; Nigam, Sonu; Arora, Prerna; Khurana, Nita; Batra, Swaraj; Mandal, Ashish Kumar



Accuracy of clinical diagnosis of idiopathic Parkinson's disease: a clinico-pathological study of 100 cases  

Microsoft Academic Search

Few detailed clinico-pathological correlations of Parkinson's disease have been published. The pathological findings in 100 patients diagnosed prospectively by a group of consultant neurologists as having idiopathic Parkinson's disease are reported. Seventy six had nigral Lewy bodies, and in all of these Lewy bodies were also found in the cerebral cortex. In 24 cases without Lewy bodies, diagnoses included progressive

A J Hughes; S E Daniel; L Kilford; A J Lees



Benefits of biomarker selection and clinico-pathological covariate inclusion in breast cancer prognostic models  

Microsoft Academic Search

INTRODUCTION: Multi-marker molecular assays have impacted management of early stage breast cancer, facilitating adjuvant chemotherapy decisions. We generated prognostic models that incorporate protein-based molecular markers and clinico-pathological variables to improve survival prediction. METHODS: We used a quantitative immunofluorescence method to study protein expression of 14 markers included in the Oncotype DX™ assay on a 638 breast cancer patient cohort with

Fabio Parisi; Ana M González; Yasmine Nadler; Robert L Camp; David L Rimm; Harriet M Kluger; Yuval Kluger



[A clinico-neurophysiological analysis of the single action of laser puncture].  


Mechanisms were studied of a single exposure to laser puncture on the basis of clinico-neurophysiological investigations in 50 patients with cochleovestibular dysfunctions in the presence of vascular affections of the brain. In a comparative evaluation of endaural versus auricular laser puncture, more pronounced changes were revealed in all the parameters studied during the course of treatment with the former modality than they were with the latter, these parameters being the patients' general well-being as judged by subjective evidence, the ability of the points to conduct electrical current, and the findings from rheoencephalography, encephaloradiothermometry, audiovestibulometry. PMID:7831885

Troshin, O V



Carcinoma ex pleomorphic adenoma in a Brazilian population: clinico-pathological analysis of 38 cases.  


Carcinoma ex pleomorphic adenoma (CXPA) is a rare tumour, with different prevalence rates reported among studies. Epidemiological studies of large series of CXPAs in developing countries are scarce. The aim of the present study was to describe Brazilian patients with CXPA; this was a retrospective study of 38 patients. Demographic and clinico-pathological features were evaluated. No preferential gender was found, and the mean age at diagnosis was 57.6 years. The most commonly involved site was the parotid, followed by the submandibular and the minor salivary glands. A prevalence of clinical stages III and IV was observed at diagnosis. The most common histological subtypes were salivary duct carcinoma, adenocarcinoma not otherwise specified, myoepithelial carcinoma, and epithelial-myoepithelial carcinoma. Moreover, by invasive phase, most were frankly invasive carcinoma. Recurrence was observed in seven out of 24 patients with outcome information available, and all were invasive cases. All seven patients died of causes related to the disease. The distributions of cases according to age, gender, tumour location, and clinical stage were similar to those reported in the literature. Frankly invasive cases presented a worse prognosis. More information is needed to further our understanding of the clinico-pathological aspects of CXPA. PMID:23561262

Mariano, F V; Noronha, A L F; Gondak, R O; Altemani, A M de A M; de Almeida, O P; Kowalski, L P



A comparative clinico-pathologic investigation of the effect of chloroquine phosphate on the eyes and brain of several animal species  

E-print Network

A COMPARATIVE CLINICO-PATHOLOGIC INVESTIGATION OF THE EFFECT OF CHLOROQUINE PHOSPHATE ON THE EYES AND BRAIN OF SEVERAL ANIMAL SPECIES A Thesis by THOMAS WILLIAM DUKES Submitted to the Graduate College of Texas A&M University in partial... Thesis by THOMAS WILLIAM DUKES Approved a -, to st ~/ + . -r e and content by: (Chairman of Committee) (Member C . '-p i(. (Member) (Head of Department) August 1969 4 3 2 2 6 8 ABSTRACT A Comparative Clinico-Pathologic Investigation of tie...

Dukes, Thomas William



Clinico-histopathological characteristics of clopidogrel-induced hepatic injury: case report and review of literature.  


Clopidogrel is a thienopyridine derivative with a relatively low occurrence of adverse side effects. Increasing evidence, however, suggests that clopidogrel may cause severe liver injury. Until now, five cases of clopidogrel-induced acute hepatitis have been reported. We describe the case of an 80-year-old man who developed symptomatic liver disease 6 weeks after 1x75 mg/day clopidogrel intake as adjunctive antiplatelet therapy for a renal artery stent implantation. Histological examination revealed severe acute hepatitis with extensive hepatocanalicular cholestasis and focal cell necrosis with a preferential zone-3 distribution of hepatic damage. In the present paper, we describe the clinico-histopathological characteristics of a case of clopidogrel-induced acute hepatitis and discuss the current literature. PMID:16825915

Höllmüller, Isolde; Stadlmann, Sylvia; Graziadei, Ivo; Vogel, Wolfgang



Clinico-Pathologic Relevance of Survivin Splice Variant Expression in Cancer  

PubMed Central

Survivin is a member of the inhibitor of apoptosis (IAP) family and has multifunctional properties that include aspects of proliferation, invasion and cell survival control. Survivin is a promising candidate for targeted cancer therapy as its expression is associated with poor clinical outcome, more aggressive clinico-pathologic features, and resistance to radiation and chemotherapy. In the present review the different properties of the Survivin splice variants are discussed and their activities correlated with different aspects of cancer cell biology, to include subcellular location. Special emphasis is placed on our current understanding of these Survivin splice variants influence on each other and on the phenotypic responses to therapy that they may control. PMID:23791888

de Necochea-Campion, Rosalia; Chen, Chien-Shing; Mirshahidi, Saied; Howard, Frank D.; Wall, Nathan R.



[Clinico-economical efficacy of angiotensin converting enzyme inhibitors in patients with arterial hypertension and ischemic heart disease].  


We conducted comparative analysis of clinico-economical efficacy of angiotensin converting enzyme inhibitors as components of combination therapy of patients with arterial hypertension and ischemic heart disease. Clinical efficacy of fosinopril, moexipril, perindopril, and ramipril was comparable: in compared groups statistically significant lowering of arterial pressure was achieved by day 6 of treatment and this lowering persisted up to day 36 of therapy with ramipril. All studied drugs were well tolerated. Ramipril was notable for highest economical efficacy determined by the method of \\"minimization of expenditures\\". Technology of assessment of clinico-economical effectiveness of preparations from the same pharmacological group can be used in compilation of standards of drug therapy of various diseases, basing on which a physician administers a concrete drug to a concrete patient. PMID:18729835

Korennova, O Iu; Petrenko, A V; Petrenko, M A; Kurt-Kovalenko, E V; Turusheva, E A; Alekseeva, S V; Mashinskaia, L G; Shupina, M I; Osipova, E A



Oncogenic osteomalacia associated with an occult phosphaturic mesenchymal tumour: clinico-radiologico-pathological correlation and ultrastructural studies.  


A middle-aged man presented with bone pain at multiple sites due to tumour-induced osteomalacia. The underlying occult phosphaturic mesenchymal tumour was identified by octreotide scan 5 years after presentation and confirmed by computed tomography. Tumour resection resulted in normalisation of blood chemistry and bone densitometry. Clinico-radiologico-pathological correlation and ultrastructural studies of the tumour threw light on the pathogenesis and pathophysiology of this rare disease. PMID:16912362

Cheung, F M F; Ma, L; Wu, W C; Siu, T H; Choi, P T; Tai, Y P



Blastic plasmacytoid dendritic cell neoplasms: clinico-immunohistochemical correlations in a series of 91 patients.  


Blastic plasmacytoid dendritic cell neoplasm is a rare clinicopathologic entity, characterized by strong skin tropism and a poor prognosis. The diagnosis is generally made by skin biopsy with appropriate immunohistochemical studies. To identify potential biological prognostic factors for blastic plasmacytoid dendritic cell neoplasm, we performed an extended clinico-immunohistochemical study on a series of 91 well-documented cases collected since 1995 by the French Study Group on Cutaneous Lymphomas. Skin biopsies were analyzed using a panel of 12 immunohistochemical markers (CD4, CD56, CD123, CD303, TCL1, CD68, CD2, CD7, TdT, Ki-67, S100, and MX-1). The results were correlated with survival. The 5 most characteristic markers of this entity (CD4, CD56, CD123, CD303, and TCL1) were expressed simultaneously in only 46% of patients. However, when 4 markers were expressed the diagnosis could still be reliably made without resorting to any additional stains. Expression of TdT and/or S100 correlated with varying degrees of maturation. Statistical survival analyses showed that CD303 expression and high proliferative index (Ki-67) were significantly associated with longer survival. PMID:24441662

Julia, Fanny; Dalle, Stephane; Duru, Gerard; Balme, Brigitte; Vergier, Béatrice; Ortonne, Nicolas; Vignon-Pennamen, Marie D; Costes-Martineau, Valérie; Lamant, Laurence; Dalac, Sophie; Delattre, Claire; Déchelotte, Pierre; Courville, Philippe; Carlotti, Agnès; De Muret, Anne; Fraitag, Sylvie; Levy, Annie; Mitchell, Andrew; Petrella, Tony



[A case of adult onset subacute sclerosing panencephalitis; sequential clinico-radiological findings over two years].  


We present a very rare case of adult onset subacute sclerosing panencephalitis (SSPE), and explain the characteristic sequential clinico-radiological findings. The patient, a twenty three-year-old man, had noticed unsteadiness in walking about two months previously. Although inosine pranobex and intrathecal interferon were administered, symptoms worsened insidiously and he became bedridden after four months. The levels of serum and CSF anti-measles IgG antibodies have not changed. Initially, supratentorial cortical atrophy was observed, especially of the left temporal lobe, but there were no other MRI signal alterations at the time. After three months, the supratentorial cortices produced low-signal intensities in T1-weighted images and in T2-weighted MRI, the cortical margin was very unclear and white matter signal intensities had become higher. Furthermore, cortices became thinner and ventricular size increased, especially for the lateral and third ventricles. SPECT examinations showed a marked reduction in cerebral blood flow and the perfusion deficits observed seemed to be closely correlated with the abnormal MRI signal patterns. Pathological examinations of biopsy samples revealed infiltration of inflammatory cells around the small vessels. As for immunohistochemical findings, CD68 positive cells were frequently observed, and this result implied the activation of microglia. Further studies are necessary to elucidate the pathogenic mechanisms of SSPE. PMID:16248401

Tajima, Yasutaka; Sudoh, Kazumasa; Matsumoto, Akihisa



Affection of immune zones in leprosy: a clinico-epidemiological study.  


The study was undertaken to evaluate the prevalence of involvement of immune zones in leprosy and to assess the clinico-epidemiological characteristics of the disease in patients presenting with immune zone involvement. 200 leprosy cases were included in this study and detailed history, clinical examination, slit-skin smears and skin biopsies were carried out on all patients. Those cases presenting with immune zone involvement were further evaluated for clinical and epidemiological characteristics of disease process. Immune zone involvement was detected in 7% of cases with male preponderance in the study. Majority of patients (85.5%) had borderline tuberculoid leprosy and midline of back was the commonest site of involvement (50% of cases). Morphologically, macular lesions were the commonest presentation (85.68%) of immune zone involvement. The study heightens the clinical awareness of the possibility of occurrence of leprous lesions on uncommon and unusual sites, which should be termed as relatively immune, rather than absolutely immune zones of leprosy. PMID:17120510

Rajashekar, T S; Singh, Gurcharan; Okade, R; Harish, M R



Viral aetiology and clinico-epidemiological features of acute encephalitis syndrome in eastern India.  


SUMMARY This study reports clinico-epidemiological features and viral agents causing acute encephalitis syndrome (AES) in the eastern Indian region through hospital-based case enrolment during April 2011 to July 2012. Blood and CSF samples of 526 AES cases were investigated by serology and/or PCR. Viral aetiology was identified in 91 (17·2%) cases. Herpes simplex virus (HSV; types I or II) was most common (16·1%), followed by measles (2·6%), Japanese encephalitis virus (1·5%), dengue virus (0·57%), varicella zoster virus (0·38%) and enteroviruses (0·19%). Rash, paresis and cranial nerve palsies were significantly higher (P < 0·05) with viral AES. Case-fatality rates were 10·9% and 6·2% in AES cases with and without viral aetiology, respectively. Simultaneous infection of HSV I and measles was observed in seven cases. This report provides the first evidence on viral aetiology of AES viruses from eastern India showing dominance of HSV that will be useful in informing the public health system. PMID:24476571

Rathore, S K; Dwibedi, B; Kar, S K; Dixit, S; Sabat, J; Panda, M



Mouse model mimics multiple sclerosis in the clinico-radiological paradox.  


The value of experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis, in deriving novel diagnostic and therapeutic input has been subject to recent debate. This study is the first to report a disseminated distribution of plaques including cranial nerves, prior to or at early stages of disease in murine adoptive transfer EAE, irrespective of the development of clinical symptoms. We induced EAE by adoptive proteolipid protein-specific T-cell transfer in 26 female SJL/J mice, and applied high-field-strength magnetic resonance imaging (MRI) scans longitudinally, assessing blood-brain barrier (BBB) disruption by gadopentate dimeglumine enhancement. We visualized inflammatory nerve injury by gadofluorine M accumulation, and phagocytic cells in inflamed tissue by very small anionic iron oxide particles (VSOP-C184). MRI was correlated with immunohistological sections. In this study, we discovered very early BBB breakdown of white and grey brain matter in 25 mice; one mouse developed exclusively spinal cord inflammation. Widely disseminated contrast-enhancing lesions preceded the onset of disease in 10 animals. Such lesions were present despite the absence of any clinical disease formation in four mice, and coincided with the first detectable symptoms in others. Cranial nerves, predominantly the optic and trigeminal nerves, showed signal intensity changes in nuclei and fascicles of 14 mice. At all sites of MRI lesions we detected cellular infiltrates on corresponding histological sections. The discrepancy between the disease burden visualized by MRI and the extent of disability indeed mimics the human clinico-radiological paradox. MRI should therefore be implemented into evaluational in vivo routines of future therapeutic EAE studies. PMID:17596194

Wuerfel, Jens; Tysiak, Eva; Prozorovski, Timour; Smyth, Maureen; Mueller, Susanne; Schnorr, Joerg; Taupitz, Matthias; Zipp, Frauke



Clinico-Microbiological Profile of Chronic Pulmonary Aspergillosis from a Tertiary Care Centre in Southern India  

PubMed Central

Background: Pulmonary aspergillosis is commonly seen in immunocompromised individuals. A significant rise has been seen in these cases in the past decade, owing to growing number of patients with impaired immune status. Aim: This study includes the detailed clinical and microbiological profiles of all the culture positive cases of pulmonary aspergillosis, detected in three years, from Jan 2008–Dec 2010, at our tertiary care centre. Methods: A hospital based observational and retrospective study was conducted to study the clinico-microbiological characteristics of patients with pulmonary aspergillosis. Respiratory specimens which showed repeated isolation of Aspergillus were included in the study. Demographic details, clinical findings and predisposing factors were noted down for all the patients. Treatment of patients with antifungal agents and their responses to treatment were also documented. Results: There were 22 patients with male to female ratio of 1.2:1 and mean age of 52.5 years. The most common underlying lung disease was presence of bronchial asthma in 27.3% (6/22) cases. Many patients (40.9%; 9/22) were on steroid treatment. Cough with expectoration was the most common symptom observed in 72.7% (16/22) cases. Microbiologically, microscopy showed positivity for the presence of gram positive, acutely branched, fungal hyphae, suggestive of Aspergillus, in all the cases. Aspergillus fumigatus was the predominant species that was isolated in 40.9% (9/22) cases. All the diagnosed patients were given either oral itraconazole or intravenous amphotericin B. A clinical improvement was observed in 72.5% (16/22) cases, but 27.3% (6/22) patients died. Conclusion: Pulmonary aspergillosis presents with non-specific clinical and radiological findings. An early suspicion and diagnosis is essential, especially in patients with underlying lung disease, to prevent dissemination and invasion. PMID:24551620

Chawla, Kiran; Kosaraju, Kranthi; Rayasam, Sridevi; Mukhopadhyay, Chiranjay



Clinico-radiological Characteristics of Spontaneous Basal Ganglia Hemorrhage, According to Regional Classification  

PubMed Central

Objective The clinico-radiologic features of the spontaneous basal ganglia hemorrhage (BGH) may often differ one from another, according to its regional location. Therefore, we attempted to classify the BGH into regional subgroups, and to extrapolate the distinct characteristics of each group of BGH. Materials and Methods A total of 103 BGHs were analyzed by retrospective review of medical records. BGH was classified according to four subgroups; anterior BGH; posterior BGH; lateral BGH; massive BGH. Results The most common BGH was the posterior BGH (56, 54.4%), followed by the lateral BGH (26, 25.2%), the massive BGH (12, 11.7%), and the anterior BGH (9, 8.7%). The shape of hemorrhage tended to be round in anterior, irregular in posterior, and ovoid in lateral BGH. A layered density of hematoma on initial computed tomography showed correlation with hematoma expansion (p = 0.016), which was observed more often in the postero-lateral group of BGH than in the anterior BGH group. Relatively better recovery from the initial insult was observed in the lateral BGH group than in the other regional BGH groups. The proportion of poor outcome (modified Rankin scale 4, 5, 6) was 100% in the massive, 41.1% in the posterior, 34.6% in the lateral, and 0% in the anterior BGH group. Conclusion We observed that BGH can be grouped according to its regional location and each group may have distinct characteristics. Thus, a more sophisticated clinical strategy tailored to each group of BGHs can be implemented. PMID:25340023

Kim, Do Young; Choo, Yeon Soo; Jang, E Wook; Chung, Joonho; Joo, Jin Yang



Verrucous lesions of the oral cavity treated with surgery: Analysis of clinico-pathologic features and outcome  

PubMed Central

Objective: Verrucous lesions of the oral cavity can be of varied histopathology. The present study evaluates the clinico-pathological features of verrucous lesions of the oral cavity and analyzes the treatment outcomes. Materials and Methods: This is a retrospective study of 15 consecutive patients who presented with verrucous lesions of the oral cavity, during the 5-year period from January 2006 to December 2010. Demographic, clinico-pathological features, treatment details, and outcomes were analyzed. Results: Fifteen patients with verrucous lesions of the oral cavity were treated with surgery as the primary modality. The mean age was 62.8 years (range 35–85 years). Wide excision of the primary lesion with adequate mucosal and soft-tissue margins was carried out. Free-flap reconstruction was done in eight patients. All patients remain loco-regionally controlled with good functional speech and swallowing outcome. Conclusions: Verrucous lesions of the oral cavity are a distinct clinical entity with varied histopathology. A surgical excision with wide margins and appropriate reconstruction is necessary to optimize the disease and functional outcome. PMID:22557899

Sadasivan, Anjana; Thankappan, Krishnakumar; Rajapurkar, Mayuri; Shetty, Sharankumar; Sreehari, Sreekala; Iyer, Subramania



The clinico-pathology and mechanisms of trypanosomosis in captive and free-living wild animals: a review.  


Reports on the clinico-pathology and mechanisms of trypanosomosis in free-living and captive wild animals showed that clinical disease and outbreaks occur more commonly among captive than free-living wild animals. This is because the free-living wild animals co-exist with the disease until subjected to captivity. In exceptional cases however, draught, starvation and intercurrent diseases often compromised trypanotolerance leading to overt trypanosomosis in free-living wild animals. Meanwhile, in captivity, space restriction, reduced social interactions, change in social herd structure, reduced specie-to-specie specific behaviors, altered habitat and translocation were the major stressors that precipitated the disease. The cumulative effect of these factors produced severe physiological and somatic stress leading to diminished immune response due to increased blood cortisol output from adrenal cortex. The major symptoms manifested were pyrexia, innapetence, increased respiration, anaemia, cachexia and death. At necropsy, pulmonary oedema, splenomegally, hepatomegally, lympadenopathy and atrophy of body fats were the gross changes encountered. At the ultra-structural level, the tissues manifested degenerative changes, haemorghages, necrosis and mononuclear cellular infiltrations. The mechanisms of cellular and tissue injuries were primarily associated with physical and metabolic activities of the organisms. From the foregoing, it is evident that stress is the underlying mechanism that compromises trypanotolerance in wild animals leading to severe clinico-pathological effects. PMID:19340600

Mbaya, A W; Aliyu, M M; Ibrahim, U I



Parasitological and clinico-epidemiological features of onchocerciasis in West Wellega, Ethiopia.  


Onchocerciasis is a disease of public health and socio-economic importance in Ethiopia. The aim of this study was to assess parasitological and clinico-epidemiological features of onchocerciasis in the Anfilo District, West Wellega, prior to implementation of Community Directed Treatment with Ivermectin (CDTI) to generate epidemiological and parasitological data for use in control program of the disease and subsequent evaluation of CDTI. A cross-sectional study was conducted in Anfilo District of West Wellega zone during a period of 1 month: from mid-August to mid-September 2006. Data on socio-demographic characteristics were collected using a standardized questionnaire prepared for this purpose. All persons were examined clinically for skin signs and symptoms of onchocerciasis. Two skin snips, one from each side of the gluteal fold were taken using blood lancet and sterilized razor blade and examined for microfilaria. All data were categorized, coded, entered in a data base and analyzed using SPSS version 15.0. for windows. A total of 1114 individuals ?15 years were examined for microfilariae (mf) of Onchocerca volvulus and onchocercal skin disease (OSD). The prevalence of onchocercal (mf) carrier was 74.8% (833/1114). In both genders, the prevalence of onchocerciasis showed direct correlations with the age of individuals (R (2) = 0.79, P < 0.05). The infection rate varied with the occupation of the study subjects, with preponderance among farmers. Among the subjects with onchocerciasis, the mf density ranged from 1.0 to 711.0 per mg of skin snip with a mean density (SD) and median values of 32.1 (61.5) and 10.4 respectively. The overall community microfilariae load (CMFL), the most sensitive parasitological indicator of onchocerciasis was 19.6. The pervasiveness of OSD among the study subjects was 26.4%. OSD was more frequent in males (32.4%) than their female counterparts (20.8%, P < 0.05). The overall prevalence of onchocercal nodule carrier, the symptom opted for determining the community-wide prevalence of onchocerciasis was 12.1%. Leopard skin, the proxy of longstanding infection of onchocerciasis in the community, was also relatively high (19.1%). The abundance of mf in skin would definitely lead to high transmission potential in the Anfilo District. The situation in the Anfilo District should call for continued CDTI, owing to success of similar recommendations for such programmes in other parts of the country and elsewhere. PMID:23542576

Dori, Geme Urge; Belay, Tariku; Belete, Habtamu; Panicker, K N; Hailu, Asrat



Clinico-demographic profile, sexual dysfunction and readiness to change in male alcohol dependence syndrome inpatients in a tertiary hospital.  


Persons with prolonged and heavy alcohol use generally suffer from alcohol dependence syndrome (ADS) and develop physical, sexual as well as psychiatric co-morbidity. Successful recovery to normalcy depends on multiple factors including patient's motivation. To study clinico-demographic profile, reasons for initiating alcohol use, sexual and psychiatric disorders and eagerness for treatment and quitting alcohol in ADS inpatients. Fifty consecutive ADS inpatients with matching controls were enrolled. Clinico-demographic profile, factors for initiating alcohol use, psychiatric and sexual co-morbidity and want for treatment and being abstinent was studied applying relevant scales. All subjects were males with a mean age of 37.5 years, 80% were married, majority were Hindu (88%) and from nuclear families (56%). Fifty two percent had an education level of Graduation or more and 68% of patients reported peer pressure to be the initiating factor for alcohol use. Seventy six percent had psychiatric co-morbidity including personality Problems and other Psychiatric disorders 19(38%), delirium tremens 14 (28.00%) and Mood disorders 12(24%).Depression being most common mood disorder (14%). Nicotine was the most common other substance of use 32 (64%). Sixty eight percent of the patient reported one or another sexual dysfunction. 68% of ADS inpatients acknowledged of having problems related to their drinking, expressed desire for change and were eager to avail treatment and to remain abstinent. ADS patients commonly suffer from psychiatric co-morbidity and sexual dysfunctions. They also wish to have effective treatment and to quit alcohol. PMID:23441492

Pandey, A K; Sapkota, N; Tambi, A; Shyangwa, P M



Cystic lung lesions in Sjogren syndrome: analysis of lymphocyte subsets in tissue with clinico-radiologic-pathologic correlation.  


Pulmonary complications associated with Sjögren syndrome (SS) have attracted attention in recent years. Sjögren syndrome has been associated with small cyst formation in salivary glands, thymus, and lungs and has been recently brought to the forefront by radiologists due to high-resolution techniques. However, pathologists are less aware of this finding unless clinico-radiologic-pathologic correlation is sought. Formation of large bullae in SS is a rare complication with potential for confusion with other diseases. Here, we present the clinical, radiologic, and pathologic findings in 3 patients with SS associated with multiple pulmonary cystic lesions. All 3 patients had a variable mixed restrictive and obstructive component of the disease. There was good correlation with the pulmonary function tests (PFTs), high-resolution computed tomographic scan, and morphology with regard to the restrictive component. The small cysts appear to correlate with the extent of obstructive changes on the PFTs. However, the large bullae do not, implying noncommunication with the conducting airways. This noncorrelation between the PFTs and extent of bullous disease with predominant involvement of lower lobes in SS enables distinction from bullous emphysema. The mechanism of bulla formation in SS appears to be different from bullous emphysema. A check valve mechanism has been proposed previously in SS, which does not explain cyst formation in the thymus. Alternately, inflammation may play a role with the key suspects being CD4 T-helper cells and perhaps NK cells. This is the first report of a clinico-radiologic-pathologic correlation with analysis of lymphocyte subsets. PMID:22658853

Jagirdar, Jaishree; Chikkamuniyappa, Shylashree; Sirohi, Deepika; McCarthy, Michael J; Peters, Jay I



[Clinico-electrocardiographic evaluation of the state of the cardiovascular system inpersonnel engaged in liquidating the consequences of the accident at the Chernobyl Atomic Power Station].  


The paper is concerned with analysis of the results of clinico-electrocardiographic investigation of 107 rescuers, engaged in the elimination of the effects of the Chernobyl accident. A high percent (27.2%) of the detectability of borderline arterial hypertension was noted among the rescuers (aged to 39) that was determined by a strong psychoemotional tension resulting from work and radiation phobia. PMID:1861595

Metliaeva, N A; Nadezhina, N M



Clinico-epidemiological study of spinal injuries in a predominantly rural population of eastern Nepal: A 10 years' analysis  

PubMed Central

Background: A clinico-epidemiological study helps to plan future preventive measures and management strategies for spinal trauma. This is a 10 years' retrospective review of spinal-injury patients treated at a tertiary health center in the eastern of Nepal to determine clinico-epidemiological aspects of spinal-injury patients in a predominantly rural population of eastern Nepal. Materials and Methods: All medical record files of patients with spinal injury from 1996 to 2005 in the Medical Record Section of BPKIHS (B. P. Koirala Institute of Health Sciences) were studied. The preformed pro forma consisting age, sex, place of living, mode of injury, hospital stay level of injury, site of injury, associated injury, Frankel grading of neural deficit and treatment modality was filled from the record files of patients. These parameters were entered in Excel 8 and analyzed by EPI INFO 2002. Details of 896 patients of spinal injury were recorded in the 10-year period of review. Results: 684 (76.35%) male and 212 (23.66%) female patients with mean age of 41.74 ± 16.53 years and 38.56 ± 15.86 years respectively were studied. Two hundred forty-two (27%) patients were from hilly districts of eastern Nepal. Fall from height [in 350 (39%) patients] was the commonest mode of spinal injury. Six hundred thirty-six (71%) patients presented with a neurological deficit. Seven hundred thirty-three (85%) patients were treated conservatively, compared to 163 (15%) surgically treated patients. One hundred forty-six (22%) patients were treated with operative interventions in the last five years. Conclusion: The study shows that the most vulnerable group for spine injury was the group of patients of productive age with late presentation (i.e., injury hospital duration ? 41.64 ± 54.24 hours) without proper prehospital management. The treatment modalities have changed (from conservative to surgical) in this part of the world. These specific observations help us in further planning for preventive measures and management in our setting. PMID:21139779

Bajracharya, Suraj; Singh, Mahipal; Singh, Girish Kumar; Shrestha, Bikram Prasad



Prolonged dynamic clinico-immunological observation of 85 patients with definite multiple sclerosis: first steps towards monitoring process activity.  


Prolonged clinico-immunological observation of 85 patients with definite multiple sclerosis (MS) was performed in order to elucidate the connections between the clinical and immune state. A battery of immunological investigations was performed, including estimation of T-cell subpopulations in blood and cerebrospinal fluid (CSF); proliferative responses of circulating lymphocytes to mitogens, recombinant interleukin-2 (rIL2) and myelin basic protein levels in different culture conditions; levels of immunoglobulin (Ig) in sera and CSF, and of Ig production in vitro; indices of IL2 synthesis and IL2 sensitivity; production of prostaglandin E2 and tumour necrosis factor (TNF) alpha by monocytes and levels of beta-endorphin in sera and supernatants phytohaemagglutinin of (PHA)-activated cells. Clinical observation was performed periodically using Kurtzke scales and was supplemented by repeated recording of evoked potentials and magnetic resonance imaging. Initial investigations showed specific differences between patients with MS and the control groups (donors and patients with other neurological disorders of the same age). Correlative and regressive analyses showed no association between immunological and clinical parameters at the initial investigation, although immunological indexes were inter-related, and indicated specific alterations in immunoregulation in MS. Retrospective analysis revealed associations between the clinical status of patients with MS and their previous immune status. Evidence of cell activation--including a decreased percentage of circulating cells with differential antigens, lower cell mitogen-induced proliferative responses in vitro, with restoration following the addition of autoserum, greater IL2 sensitivity, and increased TNF-alpha production by macrophages--often predicted the clinical manifestation of deterioration. It is proposed that the immunopathological process in MS has a number of stages with characteristic features, and that progression from one stage to another can be subclinical. No single immunological index can be used to determine stage. Only systemic alterations reflect the real situation, whilst every patient has some abnormalities. A system of clinico-immunological monitoring could severe as the basis for a new approach to the dynamic treatment of MS. PMID:7964920

Gusev, E I; Demina, T L; Boiko, A N; Pinegin, B V



The clinico-surgico-pathological spectrum of myxopapillary ependymomas--report of four unusal cases and review of the literature.  


According to the WHO grading system, myxopapillary ependymomas are assigned to WHO Grade I. However, the clinico-pathological spectrum might be very heterogenous. Herein, we report 4 cases exhibiting lumbar tumor masses, 1 causing muscular atrophy over a 30-year period, 3 displaying clinical history of persisting lumbar pain for only several weeks. All tumors were crooked with dura and spinal roots resulting in incomplete resection in three cases. On histological examination, two tumors were almost acellular and showed polycyclic hyaline and fibrotic extracellular matrix leading to differential diagnoses of chordoma, meningioma, fibrolipoma and ependymoma. Finally, together with the immunohistochemical investigations, electron microscopy led to the diagnosis of myxopapillary ependymoma, WHO Grade I, with massive degenerative changes. The other 2 cases presented with the typical neuropathology of myxopapillary ependymomas but showed local recurrence within 1 and 13 years throughout the whole neuraxis, and in 1 case additional metastases of the 3rd ventricle. Although the morphological feature of these myxopapillary ependymomas was benign, the presented cases showed that the biological behavior of myxopapillary tumors might differ greatly and that these tumors present a serious operative and diagnostic challenge. Myxopapillary ependymomas occur most often in the lumbosacral region. Due to the anatomic complexity of the cauda equina, a complete resection can be technically challenging in this region. However, a gross total resection at the primary surgery is the most predictive factor for the outcome. PMID:18257471

Schittenhelm, J; Becker, R; Capper, D; Meyermann, R; Iglesias-Rozas, J R; Kaminsky, J; Mittelbronn, M



[Interrelations between the main forms of the course of schizophrenia and the morphological phenotype of patients' constitution (clinico- anthropometric data)].  


In order to study interrelations between schizophrenia forms and the constitutional morphological type of the patients, as many as 840 schizophrenic patients and 282 normal subjects of the control group underwent ++clinico-anthropometric examinations. Comparison of the distribution of the pyknic, normosthenic and asthenic types of build-up in patients with schizophrenia and in the control group of healthy subjects did not reveal material differences and tropism of this endogenous psychosis to the constitution. It has been shown at the same time that at the probability level, the asthenic somatotype is the basis for continuous-progressive forms of the disease; the pyknic type of the build-up is based on the recurrent and shift-like forms with circular features, whereas the normosthenic somatic type forms the basis for the attack-like progressive form. The data obtained permit a conclusion that formation of schizophrenia forms is determined not only by the general pathological regularities common to the given disease but also by the individual typological peculiarities characteristic of different ++morpho-phenotypes of constitution. PMID:1661463

Kornetov, N A



PAH exposure biomarkers are associated with clinico-chemical changes in the brick kiln workers in Pakistan.  


In this study we investigated the clinico-chemical parameters and the level of exposure of brick kiln workers to polycyclic aromatic hydrocarbons (PAHs) in Punjab (Pakistan). The brick kiln workers and a non-occupationally exposed group were recruited for comparative analysis of urinary biomarkers of PAH exposure (i.e. 1-hydroxypyrene (1-OHPyr), ?-naphthol and ?-naphthol) and blood level of superoxide dismutase (SOD), as a biomarker of oxidative stress and other hematologic parameters. Questionnaires were used to document information on socio-demographic characteristics of all the subjects. The analysis of urinary biomarkers showed higher median concentrations of 1-OHPyr, and ?- and ?-naphthols in brick kiln workers (1.53, 3.65 and 1.53 ?mol/mol-Cr, respectively) than non-occupationally exposed group (0.62, 0.64 and 0.66 ?mol/mol-Cr, respectively). The 1-OHPyr in brick kiln workers was above the occupational exposure level. Among the clinical parameters of brick kiln workers, hemoglobin (Hb) and red blood cells (RBCs) were very low and closely associate with 1-OHPyr and ?-naphthol. Additionally, the white blood cells (WBCs) and superoxide dismutase (SOD) were also elevated in brick kiln workers, which suggested inflammatory symptoms and high oxidative stress. The results show that regardless of possibly being affected by the poor nutrition, the anemic state and hematological changes observed in brick kiln workers may be associated with their exposure to smoke present in the environment of brick kilns. PMID:24878696

Kamal, Atif; Malik, Riffat Naseem; Martellini, Tania; Cincinelli, Alessandra



Rare and challenging extra-axial brain lesions: CT and MRI findings with clinico-radiological differential diagnosis and pathological correlation.  


There are many kinds of extra-axial brain tumors and tumor-like lesions, and definitive diagnosis is complicated in some cases. In this pictorial essay, we present rare and challenging extra-axial brain lesions including neuroenteric cyst, primary leptomeningeal melanomatosis, isolated dural neurosarcoidosis, intradiploic epidermoid cyst, ruptured dermoid cyst, intraventricular cavernoma, and cavernous hemangioma of the skull with imaging findings and clinico-radiological differential diagnosis, including the pathologic correlation. Familiarity with these entities may improve diagnostic accuracy and patient management. PMID:25010368

Demir, Mustafa Kemal; Yap?c?er, Ozlem; Onat, Elif; Tokta?, Zafer Orkun; Akak?n, Ak?n; Urgun, Kamran; K?l?ç, Türker



Clinico-immunologic evaluation of allergy to Himalayan tree pollen in atopic subjects in India--a new record.  


Exposure to local pollen allergens has a direct bearing on the prevalence of allergic symptoms among the inhabiting atopic population. The populations in the Himalayas and around it are exposed to a variety of pollen grains from trees growing in the region, but the pollen-population interaction has not been clinically investigated. Himalayan tree pollen from five different taxa, i.e. Alnus nitida (AN), Betula utilis (BU), Cedrus deodara (CD), Mallotus phillipensis (MP) and Quercus incana (QI) were evaluated for their allergenicity in the Indian population by in vivo (skin prick test) and in vitro (ELISA) clinico-immunological methods. The presence of specific IgE against these tree pollen in the sera of skin test positive patients was taken as evidence for sensitization to these pollen. The average skin positivity in atopic populations recorded at different allergy centers in India varied from 2.2% against AN, to 4.7% against MP pollen. Significantly raised specific IgE against these pollen were observed in the sera of hypersensitive patients. The sensitization pattern to Himalayan tree pollen in these atopic populations varied. It was concluded that skin prick test positivity and raised IgE antibodies specific to AN, BU, CD, MP and QI established Himalayan tree pollen as important sensitizers in the atopic populations of India. A high incidence of skin sensitivity was observed to pollen antigens of Cedrus deodara, Mallotus phillipensis and Quercus incana in patients of Chandigarh residing in the hills and foothills of the Himalayas while Alnus nitida, Betula utilis and Cedrus deodara were important sensitizers in Delhi patients. The skin sensitization pattern against these pollen was in accordance with the level of exposure to these pollen of the subjects residing in that part of the country. PMID:16252835

Bist, Arnima; Kumar, Lata; Roy, Indrani; Ravindran, P; Gaurs, S N; Singh, A B



Low grade Endometrial Stromal Sarcoma of uterine corpus, a clinico-pathological and survey study in 14 cases  

PubMed Central

Background Endometrial stromal sarcoma (ESS) is a rare disease with probably less than 700 new cases in the USA or Europe per year. The aim of this study was to evaluate the behavior of low-grade endometrial stromal sarcoma (LGESS) in relation to their clinical and pathological features and to identify possible prognostic factors. Patients and methods Fourteen patients with histologically proven ESS were included in the analysis. Endometrial stromal sarcoma is characterized by proliferations composed of cells with Endometrial stromal cell differentiation. Low-grade endometrial stromal sarcoma has an infiltrating margin and typically show extensive worm-like vessel invasion. Results The median age was 44.35 ± 6 years. The most common presenting symptom was vaginal bleeding, occurring in twelve patients (86%). Diagnosis was made through Fractional dilatation and curettage in four patients (28.5%). Eight patients had a total abdominal hysterectomy and salpingo-ophorectomy (57%). Radiotherapy as adjuvant therapy was administered to four patients (28.5%). The median follow-up time was 45.6 months (range 24–84). The median overall survival of the 14 patients was 45.35 ± 21 months (range 20–83). Three of 14 patients demonstrated a recurrence of disease at 9, 72, and 96 months respectively. The recurrent diseases were treated with surgery, chemotherapy, and radiotherapy. No patient died of the disease. Clinico-pathological parameters did not significantly differ between patients with and without recurrence, but patients with no myometrial invasion and low mitotic count <= 5/HPF showed longer disease-free survival. Conclusion Five-year survival rate was 93%. Survival probabilities were calculated by the product limit method of Kaplan and Meier that showed, patients with no myometrial invasion and low mitotic count <= 5/HPF have longer disease-free survival, but P value was not significant. PMID:16895611

Ashraf-Ganjoei, Tahereh; Behtash, Nadereh; Shariat, Mamak; Mosavi, Asamosadat



Subclinical atherosclerosis and silent myocardial ischaemia in patients with type 2 diabetes: a protocol of a clinico-observational study  

PubMed Central

Introduction Atherosclerotic cardiovascular disease is a significant modifiable complication in patients with diabetes and subclinical atherosclerosis is considered a surrogate marker of future vascular events. The clustering of cardiometabolic-risk factors in patients with diabetes and cardiovascular disease is increasingly being recognised. Recent evidence indicates that 20–50% of asymptomatic patients with diabetes may have silent coronary heart disease. However, the identification of subclinical atherosclerosis and silent myocardial ischaemia in patients with diabetes has been less well-explored, especially in low-resource population settings where cost-effective non-invasive clinical tools are available. The objective of this study is to identify patients with physician-diagnosed diabetes who are at risk of developing future cardiovascular events measured as subclinical atherosclerosis and silent myocardial ischaemia in an urban population of Eastern India. Methods and analysis This is a cross-sectional clinico-observational study. A convenience sampling of approximately 350 consecutive patients with type 2 diabetes based on predefined inclusion and exclusion criteria will be identified at an urban diabetes center. This estimated sample size is based on an expected prevalence of silent myocardial ischaemia of 25% (± 5%), we computed the required sample size using OpenEpi online software assuming an ? level of 0.05 (95% CI) to be 289. On factoring 20% non-response the estimated sample size is 350. Previously validated questionnaire tools and well-defined clinical, anthropometric and biochemical measurements will be utilised for data collection. The two primary outcomes—subclinical atherosclerosis and silent myocardial ischaemia will be measured using carotid intima-media thickness and exercise tolerance testing, respectively. Descriptive and multivariate logistic regression statistical techniques will be employed to identify ‘at risk’ patients with diabetes, and adjusted for potential confounders. Ethics and dissemination Ethical approval was granted by the institutional review board of Kalinga Institute of Medical Sciences, Bhubaneshwar, India. Data will be presented at academic fora and published in peer-reviewed journals. PMID:25332812

Prasad, D S; Kabir, Zubair; Devi, K Revathi; Dash, A K; Das, B C



Outcome of pulmonary embolism and clinico-radiological predictors of mortality: Experience from a university hospital in Saudi Arabia  

PubMed Central

OBJECTIVES: The objective of this study is to determine the outcome of pulmonary embolism (PE) and the clinico-radiological predictors of mortality in a university hospital setting. METHODS: A Prospective observational study conducted at King Khalid University Hospital, Riyadh Saudi Arabia between January 2009 and 2012. A total of 105 consecutive patients (49.9 ± 18.7 years) with PE diagnosed by computed tomography pulmonary angiography were followed until death or hospital discharge. RESULTS: Overall in hospital mortality rate was 8.6%, which is lower than other international reports. Two-thirds of patients developed PE during the hospitalization. The most common risk factors were surgery (35.2%), obesity (34.3%) and immobility (30.5%). The localization of the embolus was central in 32.4%, lobar in 19% and distal in 48.6%. A total of 26 patients (25%) had evidence of right ventricular strain and 14 (13.3%) were hypotensive. Multivariate analysis revealed that heart failure (Beta = ?0.53, P < 0.001), palpitation (Beta = ?0.24, P = 0.014) and high respiratory rate (Beta = ?0.211, P < 0.036) were significant predictors of mortality. There was no significant difference in the localization of the embolus or obstruction score between survivors and non-survivors. CONCLUSION: The outcome of PE is improving; however, it remains an important risk factor for mortality in hospitalized patients. Congestive heart failure, tachypnea and tachycardia at presentation were associated with higher mortality. These factors need to be considered for risk stratification and management decisions of PE patients. Radiological quantification of clot burden was not a predictor of death. PMID:24551013

Al Otair, Hadil A. K.; Al-Boukai, Ahmad A.; Ibrahim, Gehan F.; Al Shaikh, Mashael K.; Mayet, Ahmed Y.; Al-Hajjaj, Mohamed S.



Clinico-pathological correlation of E-cadherin expression at the invasive tumor front of Indian oral squamous cell carcinomas: An immunohistochemical study  

PubMed Central

Background: Recent studies have indicated that although malignant cells at the invasive tumor front, bare morphological resemblance to the cells at central portion of the tumor, their molecular character differs significantly. E-cadherin is a cell-cell adhesion molecule that connects epithelial cells. This study attempts to correlate the E-cadherin expression at the invasive tumor front with tumor differentiation along with its clinico-pathological parameters. Materials and Methods: Immunohistochemical staining with E-cadherin was carried out on archival cases of primary oral squamous cell carcinomas (n = 30). The E-cadherin expression at the invasive tumor front was analyzed and was linked to clinico-pathological parameters including patient prognosis. Results: The downregulation of E-cadherin expression at the invasive tumor edge when compared with patient's prognosis yielded a significant correlation (P = 0.041) but its correlation with the degree of differentiation determined was not significant (P = 0.27). Also, its association with tumor size and lymph node status was negative. Conclusions: Loss of E-cadherin expression at the invasive tumor front is an important event in the progression of oral squamous cell carcinomas. Tumors with a loss of expression of E-cadherin are those which had a poor prognosis

Mehendiratta, Monica; Solomon, Monica Charlotte; Boaz, Karen; Guddattu, Vasudeva; Mohindra, Aashima



Chronic lymphocytic leukemia in the elderly: clinico-biological features, outcomes, and proposal of a prognostic model.  


We investigated the clinico-biological features, outcomes, and prognosis of 949 patients with chronic lymphocytic leukemia according to age. No biological differences (cytogenetics by fluorescent in situ hybridization, IGHV, ZAP-70, CD38, NOTCH1, SF3B1) were found across age groups. Elderly patients (>70 years; n=367) presented more frequently with advanced disease (Binet C/Rai III-IV: 10/12% versus 5/5%; P<0.001), were treated less frequently (23.8% versus 41.9% at 3 years; P<0.001) and in most cases did not receive highly effective regimens and thus had a lower overall response rate (49% with 14% having complete responses versus 69% with 31% having complete responses; P<0.001). The elderly patients also had a shorter overall survival (6.6 versus 13.3 years; P<0.001) and higher disease-unrelated mortality (34.9% versus 6.9% at 10 years; P<0.001). However, disease-attributable mortality was not significantly different between younger and older patients. A combination of Binet stage, ZAP-70 level, ?2-microglobulin concentration and comorbidity identified two risk groups (low-risk: 0-1 parameters; high-risk: 2-4 parameters) with different overall survivals (median: 6.8 versus 11.4 years, P<0.001). In patients requiring treatment, comorbidity at treatment (Cumulative Illness Rating Scale-T>4; hazard ratio 2.2, P<0.001) and response (treatment failure versus response: hazard ratio 1.60, P<0.04) were the most important prognostic factors for overall survival. In conclusion, in our series, elderly patients with chronic lymphocytic leukemia did not present with any biological features distinct from those of younger patients, but did have a poorer clinical outcome. This study highlights the importance of comprehensive medical care, achieving response to therapy, and specific management strategies for elderly patients with chronic lymphocytic leukemia. PMID:24972773

Baumann, Tycho; Delgado, Julio; Santacruz, Rodrigo; Martínez-Trillos, Alejandra; Royo, Cristina; Navarro, Alba; Pinyol, Magda; Rozman, María; Pereira, Arturo; Villamor, Neus; Aymerich, Marta; López, Cristina; Carrió, Anna; Montserrat, Emili



Chronic lymphocytic leukemia in the elderly: clinico-biological features, outcomes, and proposal of a prognostic model  

PubMed Central

We investigated the clinico-biological features, outcomes, and prognosis of 949 patients with chronic lymphocytic leukemia according to age. No biological differences (cytogenetics by fluorescent in situ hybridization, IGHV, ZAP-70, CD38, NOTCH1, SF3B1) were found across age groups. Elderly patients (>70 years; n=367) presented more frequently with advanced disease (Binet C/Rai III-IV: 10/12% versus 5/5%; P<0.001), were treated less frequently (23.8% versus 41.9% at 3 years; P<0.001) and in most cases did not receive highly effective regimens and thus had a lower overall response rate (49% with 14% having complete responses versus 69% with 31% having complete responses; P<0.001). The elderly patients also had a shorter overall survival (6.6 versus 13.3 years; P<0.001) and higher disease-unrelated mortality (34.9% versus 6.9% at 10 years; P<0.001). However, disease-attributable mortality was not significantly different between younger and older patients. A combination of Binet stage, ZAP-70 level, ?2-microglobulin concentration and comorbidity identified two risk groups (low-risk: 0–1 parameters; high-risk: 2–4 parameters) with different overall survivals (median: 6.8 versus 11.4 years, P<0.001). In patients requiring treatment, comorbidity at treatment (Cumulative Illness Rating Scale-T>4; hazard ratio 2.2, P<0.001) and response (treatment failure versus response: hazard ratio 1.60, P<0.04) were the most important prognostic factors for overall survival. In conclusion, in our series, elderly patients with chronic lymphocytic leukemia did not present with any biological features distinct from those of younger patients, but did have a poorer clinical outcome. This study highlights the importance of comprehensive medical care, achieving response to therapy, and specific management strategies for elderly patients with chronic lymphocytic leukemia. PMID:24972773

Baumann, Tycho; Delgado, Julio; Santacruz, Rodrigo; Martinez-Trillos, Alejandra; Royo, Cristina; Navarro, Alba; Pinyol, Magda; Rozman, Maria; Pereira, Arturo; Villamor, Neus; Aymerich, Marta; Lopez, Cristina; Carrio, Anna; Montserrat, Emili



Clinico-pathological analysis of renal cell carcinoma demonstrates decreasing tumour grade over a 17-year period  

PubMed Central

Introduction: Renal cell carcinoma (RCC) represents about 3% of adult malignancies in Ireland. Worldwide there is a reported increasing incidence and recent studies report a stage migration towards smaller tumours. We assess the clinico-pathological features and survival of patients with RCC in a surgically treated cohort. Methods: A retrospective analysis of all nephrectomies carried out between 1995 and 2012 was carried out in an Irish tertiary referral university hospital. Data recorded included patient demographics, size of tumour, tumour-node-metastasis (TNM) classification, operative details and final pathology. The data were divided into 3 equal consecutive time periods for comparison purposes: Group 1 (1995–2000), Group 2 (2001–2006) and Group 3 (2007–2012). Survival data were verified with the National Cancer Registry of Ireland. Results: In total, 507 patients underwent nephrectomies in the study period. The median tumour size was 5.8 cm (range: 1.2–20 cm) and there was no statistical reduction in size observed over time (p = 0.477). A total of 142 (28%) RCCs were classified as pT1a, 111 (21.9%) were pT1b, 67 (13.2%) were pT2, 103 (20.3%) were pT3a, 75 (14.8%) were pT3b and 9 (1.8%) were pT4. There was no statistical T-stage migration observed (p = 0.213). There was a significant grade reduction over time (p = 0.017). There was significant differences noted in overall survival between the T-stages (p < 0.001), nuclear grades (p < 0.001) and histological subtypes (p = 0.022). Conclusion: There was a rising incidence in the number of nephrectomies over the study period. Despite previous reports, a stage migration was not evident; however, a grade reduction was apparent in this Irish surgical series. We can demonstrate that tumour stage, nuclear grade and histological subtype are significant prognosticators of relative survival in RCC. PMID:24839483

Nason, Gregory J.; McGuire, Barry B.; Kelly, Michael E.; Murphy, Theodore M.; Looney, Aisling T.; Byrne, Damien P.; Mulvin, David W.; Galvin, David J.; Quinlan, David M.; Lennon, Gerald M.



[The place and significance of the autonomic dystonia syndrome in the clinico-pathophysiological structure of the late sequelae of mild closed craniocerebral trauma].  


Analysis of the incidence, clinico-pathophysiological structure and dynamics of vegetovascular disorders in subjects with a history of mild closed craniocerebral injuries has demonstrated that in the majority of them, even practically healthy, functional insufficiency of vegetovascular functions is seen for many years after injury. Clinically, it manifests under the influence of diverse harmful exo- and endogenous factors, undergoes circadian changes, is altered during magnetic storms, in the course of traumatic disease and nonmedicamentous correction (by methods of adaptive bioregulation according to heart rhythm parameters, craniocerebral hypothermia, etc). It has been shown that initially transitory, reversible vegetovascular disturbances, provided they were not initially removed, transform with years to more stable vegetotrophic disorders and become risk factor of cerebrovascular diseases in the given group. PMID:1338146

Shogam, I I; Ta?tslin, B V; Pertsev, G D; Melikhov, M S; Cherevatenko, G F; Korshniak, T V; Korshniak, V A; Azar'iants, M K



MICrocephaly, disproportionate pontine and cerebellar hypoplasia syndrome: A clinico-radiologic phenotype linked to calcium/calmodulin-dependent serine protein kinase gene mutation  

PubMed Central

MICrocephaly, disproportionate pontine and cerebellar hypoplasia (MICPCH) syndrome, a rare X-linked disorder, generally seen in girls, is characterized by neurodevelopmental delay, microcephaly, and disproportionate pontine and cerebellar hypoplasia. It is caused by inactivating calcium/calmodulin-dependent serine protein kinase (CASK) gene mutations. We report a 2-year-old girl with severe neurodevelopmental delay, microcephaly, minimal pontine hypoplasia, cerebellar hypoplasia, and normal looking corpus callosum, with whom the conventional cytogenetic studies turned out to be normal, and an array-comparative genomic hybridization (a-CGH) analysis showed CASK gene duplication at Xp11.4. Our case highlights the importance of using clinico-radiologic phenotype to guide genetic investigation and it also confirms the role of a-CGH analysis in establishing the genetic diagnosis of MICPCH syndrome, when conventional cytogenetic studies are inconclusive. PMID:23901204

Saleem, Rashid; Setty, Gururaj; Hussain, Nahin



[Obstructive sleep apnea syndrome in patients with acute myocardial infarction: timing of onset of the disease, clinico-functional and some other characteristics].  


With the aim of elucidating special features of the course of acute myocardial infarction (MI) in patients with obstructive sleep apnea syndrome (OSA) we retrospectively studied clinico-functional parameters of 476 patients including 64 (13.3%) who had episodes of apnea during sleep. Frequency of OSA was 1.3 times greater in overweight patients, and 2.3 times greater in those with history of diabetes mellitus. Development of MIs in patients with OSA more often occurred during night or early morning (relative risk 6.00-7.41) and depended on the severity of OSA. Patients with MI and OSA had lowering of blood levels of high density lipoproteins, elevation of levels of triglycerides and high sensitive C-reactive protein. We noted the role of excessive neurohumoral activity in these processes. A conclusion was made about necessity of timely diagnosis of OSA during MI and timely correction of the revealed pathophysiological traits. PMID:23548424

Ivanov, A P; Rostorotskaia, V V; Kliukvin, D V; Él'gardt, I A



The clinico-pathological spectrum of Focal Cortical Dysplasias: a consensus classification proposed by an ad hoc Task Force of the ILAE Diagnostic Methods Commission  

PubMed Central

Focal cortical dysplasias (FCDs) are localized regions of malformed cerebral cortex and are very frequently associated with epilepsy in both children and adults. A broad spectrum of histopathology has been included in the diagnosis of FCD. Characteristic findings include aberrant radial or tangential lamination of the neocortex (FCD Type I) and cytological abnormalities (FCD Type II). An ILAE task force has re-evaluated available data and proposes a clinico-pathologic classification system of FCDs. The major change since a prior classification represents the introduction of FCD Type III, which occurs in combination with Hippocampal Sclerosis (FCD Type IIIa), or with epilepsy-associated tumors (FCD Type IIIb). FCD Type IIIc is found adjacent to vascular malformations, whereas FCD Type IIId can be diagnosed in association with epileptogenic lesions acquired in early life (i.e., traumatic injury, ischemic injury or encephalitis). Hence, FCD Type I will now refer to isolated lesions, which present either as radial (FCD Type Ia) or tangential (FCD Type Ib) dyslamination of the neocortex, microscopically identified in one or multiple lobes. FCD Type II is an isolated lesion characterized by cortical dyslamination and dysmorphic neurons without (Type IIa) or with balloon cells (Type IIb). Architectural abnormalities adjacent to or within gross malformations of cortical development are frequently observed and not distinguished as a specific FCD variant. This three-tiered classification system will help to better characterize specific clinico-pathological entities and is an important basis to further explore imaging, electro-clinical features, and postsurgical seizure control as well as underlying molecular pathomechanisms. PMID:21219302

Blümcke, Ingmar; Thom, Maria; Aronica, Eleonora; Armstrong, Dawna D.; Vinters, Harry V.; Palmini, Andre; Jacques, Thomas S; Avanzini, Giuliano; Barkovich, A. James; Battaglia, Giorgio; Becker, Albert; Cepeda, Carlos; Cendes, Fernando; Colombo, Nadia; Crino, Peter; Cross, J. Helen; Delalande, Olivier; Dubeau, François; Duncan, John; Guerrini, Renzo; Kahane, Philippe; Mathern, Gary; Najm, Imad; Özkara, Çi?dem; Raybaud, Charles; Represa, Alfonso; Roper, Steven N.; Salamon, Noriko; Schulze-Bonhage, Andreas; Tassi, Laura; Vezzani, Annamaria; Spreafico, Roberto



A Study on Clinico-Mycological Profile, Aetiological Agents and Diagnosis of Onychomycosis at a Government Medical College Hospital in Kashmir  

PubMed Central

Background: Onychomycosis is a major public health problem with a high incidence, associated morbidity and a long lasting treatment with anti-fungal agents. This study was carried out to know the clinico-mycological pattern of onychomycosis, which could help in the control of this infection. Aims: The aim of this study was to determine the prevalence of various causative agents of onychomycosis and to study the clinical and mycological patterns of onychomycosis. Material and Methods: This was a prospective study which was carried over a period of one year, from 1st February 2011 to 31st January 2012 on samples from 150 patients with clinically suspected nail infections, who attended the Dermatology Department of SKIMS Medical college, Kashmir, India. The nails were evaluated clinically and the nail samples were subjected to direct microscopy and culture. Results: 60% samples were found to be positive by direct microscopy and culture. Males were infected more than females. The commonest age group which was infected was the 21-30 years age group. Finger nails were affected more frequently than toe nails and distolateral subungal onychomycosis was the most common clinical type of infection which was seen in 64.44% patients. The aetiological agents were dermatophytes (61.66%), Non–Dermatophyte Moulds (NDM) (31.66%) and yeasts (6.66%). Among dermatophytes, T. rubrum was the commonest aetiological agent. Conclusion: Although dermatophytes were the main causative agents, NDM and yeasts were also not uncommon aetiological agents of onychomycosis. This study also emphasized the need of performing both a direct examination and culture to improve sensitivity. Since onychomycosis can cause physical, psycological and occupational problems, the clinico-epidemiological data can be helpful in development of preventive and diagnostic strategies. PMID:24179915

Lone, Rubeena; Bashir, Deeba; Ahmad, Shabir; Syed, Arshi; Khurshid, Syed



Spindle cell lipoma-like tumor, solitary fibrous tumor and myofibroblastoma of the breast: a clinico-pathological analysis of 13 cases in favor of a unifying histogenetic concept  

Microsoft Academic Search

We reviewed the clinico-pathological features of a series of 13 cases of benign spindle stromal tumors (BSSTs) of the breast relating to a basic common theme consisting of a well-circumscribed proliferation of vimentin+\\/CD34+\\/BCL-2+\\/CD99+ spindly to oval-epithelioid cells, variably arranged in haphazard to short fascicular growth pattern, with interspersed thick or thin collagen bands. Morphological variations included atypical mono- or multi-nucleated

Gaetano Magro; Michele Bisceglia; Michal Michal; Vincenzo Eusebi



Clinico-Histopathological Analysis of Neoplastic and Non-Neoplastic Lesions of the Ovary: A 3-Year Prospective Study in Dhule, North Maharashtra, India  

PubMed Central

Background: Ovary is the commonest site of neoplastic and non-neoplastic lesion, can present in childhood to postmenopausal age group and accounts for the most prevalent cause of hospital admissions. Aim: This study was done to analyse the frequency of ovarian lesions their clinico-histological features in a rural set up. Materials and Methods: This is a prospective study of 145 ovarian lesions at tertiary care hospital over a period of 3yr. All the relevant clinical data of patients analysed from hospital record file. Results: The total number of ovarian lesions studied during study period was 145 cases, amongst them 75 were non-neoplastic and remaining 70 were neoplastic. The most common non-neoplastic lesion seen was solitary follicular cysts i.e. 56 cases (74.66%), followed by corpus luteal cysts 15 cases (20%). Among the 70 neoplastic ovarian lesions 55(78.57%) cases were benign, 1(1.42%) case was at borderline and 14 (20%) cases were malignant. In benign ovarian neoplasm, most commonly seen lesion were serous cystadenoma followed by benign cystic teratoma. In malignant cases, maximum were of serous cystadenocarcinoma, followed by mucinous cystadenocarcinoma and metastatic tumours. Conclusion: Ovarian lesion possess wide gamut of histology. Specific diagnoses are made on routine gross and histological examination or in certain difficult cases require immunohistochemistry. PMID:25302198

N.V., Dravid; P.N., Deore; D.B., Nikumbh; K.H., Suryawanshi



Clinico-biological features of 5202 patients with acute lymphoblastic leukemia enrolled in the Italian AIEOP and GIMEMA protocols and stratified in age cohorts  

PubMed Central

The outcome of children and adults with acute lymphoblastic leukemia is markedly different. Since there is limited information on the distribution of clinico-biological variables in different age cohorts, we analyzed 5202 patients with acute lymphoblastic leukemia enrolled in the Italian multicenter AIEOP and GIMEMA protocols and stratified them in nine age cohorts. The highest prevalence of acute lymphoblastic leukemia was observed in children, although a second peak was recorded from the 4th decade onwards. Interestingly, the lowest incidence was found in females between 14–40 years. Immunophenotypic characterization showed a B-lineage in 85.8% of patients: a pro-B stage, associated with MLL/AF4 positivity, was more frequent in patients between 10–50 years. T-lineage leukemia (14.2%) was rare among small children and increased in patients aged 10–40 years. The prevalence of the BCR/ABL1 rearrangement increased progressively with age starting from the cohort of patients 10–14 years old and was present in 52.7% of cases in the 6th decade. Similarly, the MLL/AF4 rearrangement constantly increased up to the 5th decade, while the ETV6/RUNX1 rearrangement disappeared from the age of 30 onwards. This study shows that acute lymphoblastic leukemia in adolescents and young adults is characterized by a male prevalence, higher percentage of T-lineage cases, an increase of poor prognostic molecular markers with aging compared to cases in children, and conclusively quantified the progressive increase of BCR/ABL+ cases with age, which are potentially manageable by targeted therapies. PMID:23716539

Chiaretti, Sabina; Vitale, Antonella; Cazzaniga, Gianni; Orlando, Sonia Maria; Silvestri, Daniela; Fazi, Paola; Valsecchi, Maria Grazia; Elia, Loredana; Testi, Anna Maria; Mancini, Francesca; Conter, Valentino; te Kronnie, Geertruy; Ferrara, Felicetto; Di Raimondo, Francesco; Tedeschi, Alessandra; Fioritoni, Giuseppe; Fabbiano, Francesco; Meloni, Giovanna; Specchia, Giorgina; Pizzolo, Giovanni; Mandelli, Franco; Guarini, Anna; Basso, Giuseppe; Biondi, Andrea; Foa, Robin



Validation of the prognostic gene portfolio, ClinicoMolecular Triad Classification, using an independent prospective breast cancer cohort and external patient populations  

PubMed Central

Introduction Using genome-wide expression profiles of a prospective training cohort of breast cancer patients, ClinicoMolecular Triad Classification (CMTC) was recently developed to classify breast cancers into three clinically relevant groups to aid treatment decisions. CMTC was found to be both prognostic and predictive in a large external breast cancer cohort in that study. This study serves to validate the reproducibility of CMTC and its prognostic value using independent patient cohorts. Methods An independent internal cohort (n = 284) and a new external cohort (n = 2,181) were used to validate the association of CMTC between clinicopathological factors, 12 known gene signatures, two molecular subtype classifiers, and 19 oncogenic signalling pathway activities, and to reproduce the abilities of CMTC to predict clinical outcomes of breast cancer. In addition, we also updated the outcome data of the original training cohort (n = 147). Results The original training cohort reached a statistically significant difference (p < 0.05) in disease-free survivals between the three CMTC groups after an additional two years of follow-up (median = 55 months). The prognostic value of the triad classification was reproduced in the second independent internal cohort and the new external validation cohort. CMTC achieved even higher prognostic significance when all available patients were analyzed (n = 4,851). Oncogenic pathways Myc, E2F1, Ras and ?-catenin were again implicated in the high-risk groups. Conclusions Both prospective internal cohorts and the independent external cohorts reproduced the triad classification of CMTC and its prognostic significance. CMTC is an independent prognostic predictor, and it outperformed 12 other known prognostic gene signatures, molecular subtype classifications, and all other standard prognostic clinicopathological factors. Our results support further development of CMTC portfolio into a guide for personalized breast cancer treatments. PMID:24996446




E-print Network

MANTENIMIENTO CON PILATES FUNDAMENTACI�N Esta disciplina pretende fusionar la gimnasia de mantenimiento con los beneficios que conlleva el método Pilates. Para ello vamos a definir el método Pilates como un sistema de entrenamiento físico y mental creado a principios del siglo XX por Joseph Pilates

Escolano, Francisco


Automated Quantitative Analysis of p53, Cyclin D1, Ki67 and pERK Expression in Breast Carcinoma Does Not Differ from Expert Pathologist Scoring and Correlates with Clinico-Pathological Characteristics  

PubMed Central

There is critical need for improved biomarker assessment platforms which integrate traditional pathological parameters (TNM stage, grade and ER/PR/HER2 status) with molecular profiling, to better define prognostic subgroups or systemic treatment response. One roadblock is the lack of semi-quantitative methods which reliably measure biomarker expression. Our study assesses reliability of automated immunohistochemistry (IHC) scoring compared to manual scoring of five selected biomarkers in a tissue microarray (TMA) of 63 human breast cancer cases, and correlates these markers with clinico-pathological data. TMA slides were scanned into an Ariol Imaging System, and histologic (H) scores (% positive tumor area x staining intensity 0–3) were calculated using trained algorithms. H scores for all five biomarkers concurred with pathologists’ scores, based on Pearson correlation coefficients (0.80–0.90) for continuous data and Kappa statistics (0.55–0.92) for positive vs. negative stain. Using continuous data, significant association of pERK expression with absence of LVI (p = 0.005) and lymph node negativity (p = 0.002) was observed. p53 over-expression, characteristic of dysfunctional p53 in cancer, and Ki67 were associated with high grade (p = 0.032 and 0.0007, respectively). Cyclin D1 correlated inversely with ER/PR/HER2-ve (triple negative) tumors (p = 0.0002). Thus automated quantitation of immunostaining concurs with pathologists’ scoring, and provides meaningful associations with clinico-pathological data. PMID:24213463

Cass, Jamaica D.; Varma, Sonal; Day, Andrew G.; Sangrar, Waheed; Rajput, Ashish B.; Raptis, Leda H.; Squire, Jeremy; Madarnas, Yolanda; SenGupta, Sandip K.; Elliott, Bruce E.



Evaluation of Serum Levels of HER2, MMP-9, Nitric Oxide, and Total Antioxidant Capacity in Egyptian Breast Cancer Patients: Correlation with Clinico-Pathological Parameters.  


Breast cancer is by far the most common cancer in women worldwide and the main cause of cancer-related mortality. Breast cancer accounts for 38% of all malignancies among Egyptian women. The aim of our study was to evaluate the serum levels of human epidermal growth factor receptor-2 (HER2), matrix metalloproteinase-9 (MMP-9), nitric oxide (NO), and total antioxidant capacity (TAC) in breast cancer patients and to correlate these markers with clinico-pathological parameters. Serum HER2, MMP-9, and carcinoma antigen 15-3 (CA 15-3) were assessed in 80 breast cancer patients and ten healthy subjects as a control group by the enzyme-linked immunosorbent assay (ELISA) technique while NO and TAC were assessed by a colorimetric method. Serum HER2 was ?15 ng/mL in nine patients (11.3%). High HER2 ECD levels were significantly associated with tissue HER2 (P<0.0001), metastasis (P= 0.0024), and negativity of both estrogen (P=0.0075) and progesterone (P=0.0239) receptors. Serum MMP-9 (P=0.0013), NO (P<0.0001), and CA 15-3 (P<0.0001) were significantly increased while serum TAC was significantly (P=0.01) decreased in breast cancer patients as compared to the control group. Serum MMP-9 was increased significantly (P=0.028) in metastatic patients as compared to non-metastatic patients. We found a positive correlation between serum HER2 and CA 15-3 (r=36, p=0.005). In conclusion, serum HER2 reflects the tissue HER2 status of breast cancer, so the determination of serum HER2 is helpful in assessing HER2 status, but in addition, a high level may reflect metastatic disease. Also, serum MMP-9 can be useful for denoting the development of metastasis in breast cancer patients. Follow-up is needed to evaluate the value of serum HER2 and MMP-9 as prognostic markers. PMID:24634847

Rashad, Yara A; Elkhodary, Tawfik R; El-Gayar, Amal M; Eissa, Laila A



Entrevistas con Eduardo Pavlovsky  

E-print Network

ahora se estudia con microcirugía es que cada golpe produce una microhemorragia; es decir, que no se ven a la visión normal pero cuando haces una autopsia, te das cuenta que el cerebro del boxeador tiene microhemorragias. De alguna manera los...

Giella, Miguel Á ngel



The Con Test  

ERIC Educational Resources Information Center

In this article, the author describes the format of the Con Test, an Australian television game show which followed the same general rules and game play as the UK show PokerFace. At the end of each round a contestant needs to decide whether or not he or she should fold. A contestant needs to know how likely it is that he or she is in last place.…

Fletcher, Michael



Nam Con Son Basin  

SciTech Connect

The Nam Con Son basin is the largest oil and gas bearing basin in Vietnam, and has a number of producing fields. The history of studies in the basin can be divided into four periods: Pre-1975, 1976-1980, 1981-1989, and 1990-present. A number of oil companies have carried out geological and geophysical studies and conducted drilling activities in the basin. These include ONGC, Enterprise Oil, BP, Shell, Petro-Canada, IPL, Lasmo, etc. Pre-Tertiary formations comprise quartz diorites, granodiorites, and metamorphic rocks of Mesozoic age. Cenozoic rocks include those of the Cau Formation (Oligocene and older), Dua Formation (lower Miocene), Thong-Mang Cau Formation (middle Miocene), Nam Con Son Formation (upper Miocene) and Bien Dong Formation (Pliocene-Quaternary). The basement is composed of pre-Cenozoic formations. Three fault systems are evident in the basin: north-south fault system, northeast-southwest fault system, and east-west fault system. Four tectonic zones can also be distinguished: western differentiated zone, northern differentiated zone, Dua-Natuna high zone, and eastern trough zone.

Tin, N.T.; Ty, N.D.; Hung, L.T.



A clinical study of cysts of the maxillofacial region; and an assessment of clinico-radiologico-pathological variables affecting the formulation of a comprehensive patient need based treatment plan  

PubMed Central

Objectives: Evaluation of clinical presentation of cystic lesions of the maxillofacial region, their relation to radiological picture, and treatment planning so as to plan and execute a patient need based treatment modality after co-relating it to the eventual histopathological diagnosis. Methods: 25 cases with clinico-radiological diagnosis of a cyst were selected and treated, and the diagnosis was co-related to the eventual histopathological diagnosis. The patients were followed up for at least 3 months (3-12 months). An attempt was made to underline patient and lesion related variables having a bearing on the choice of treatment modality in each case. Results: Out of 25 patients, 28% were females and 72% males. Commonly affected age groups were 11-20 (40%) and 31-40 years (24%). 76% of 25 patients complained of swelling on the first visit. 96% lesions were related to jaws, of which 15 were in the mandible and 9 were in the maxilla. 58.33% bone lesions had cortical expansion. 92% lesions were confirmed to be cysts histopathologically. Two were ameloblastomas. 80% patients underwent enucleation with various adjunctive procedures. 32% patients faced temporary post operative complications. No recurrences were observed. Radiological presentation of lesions and patient's age were found to be the two most important radiological and clinical variables affecting treatment planning. Conclusions: A comprehensive patient need based treatment plan can be reached only after taking various patient and lesion related variables (which may manifest as clinical, radiological or histological parameters) into consideration.

Paul, Samrity; Kapoor, Vinod; Kumar, Munish; Narula, Ravi; Kapoor, Varun; Kapoor, Upasna



Una entrevista con Emilio Carballido.  

E-print Network

. Volví a Córdoba poco antes de la adolescencia y entonces siempre estuve ya con muchos contactos en Córdoba, pero viviendo allá sin estudiar. Yo perdí años de escuela por irme a vivir a Córdoba. Es decir, yo llevé mi carrera con muchas lagunas, de... chico. Entonces escojo lugares chicos. Tomemos el caso de El jardín de los cerezos, Un enemigo del pueblo, El padre y ciertas obras muy respetables que realmente no puede uno decir que son costumbristas. Bueno, las mías no es que las ponga en esa...

Vé lez, Joseph F.



FloCon 2011 Proceedings.  

National Technical Information Service (NTIS)

At FloCon 2011, participants focused on learning about their networks and confirming what we know about them. Participants explored a wide range of topics and discussed dark space, how many web servers you're actually operating, spam, and DNS servers and ...

T. Zseby



INFORMATICA Preparazione delle presentazioni con  

E-print Network

INFORMATICA Preparazione delle presentazioni con Microsoft PowerPoint 2010 1 PROGRAMMA ! L buona presentazione 4 #12;L'AMBIENTE ! Microsoft PowerPoint è una applicazione della suite a pagamento " Microsoft Office PowerPoint 2010. 5 ALTERNATIVA ! In alternativa esiste Impress della suite Apache Open

Sproston, Jeremy


Calidad de vida relacionada con la salud de pacientes infectados por VIH medida por el Cuestionario de Salud SF36  

Microsoft Academic Search

Objectives: The aim of the study was to known the influence of HIV- infection in healthrelated quality of life (HRQL). We have used clinico- immune variables and progressionmortality presented by the disease. Patients and methods: From March 1997 through March 1998 a total of 300 HIV-infected patients were carried out the Health Survey SF-36. We included a control group (also

M. A. García Ordóñez; J. J. Mansilla Francisco; E. Nieto Aragón; M. R. Cereto; F. Salas Samper; M. Vallejo Díaz; J. Martínez González



todasuvida: Las personas con diabetes son ms  

E-print Network

diabetes Controlesu todasuvida: Las personas con diabetes son más propensas a padecer de enfermedades del corazón que quienes no tienen diabetes. Boletín 631 D Las personas con diabetes tienen mayor- res relacionados con la diabetes, como derrame cerebral, mala circulación en las piernas y pies e


[Clinico-pathological collations in borreliosis].  


Borreliosis is an infectious disease caused by spirochetal microorganisms Borrelia burgdorferi transmitted by ticks. Due to versatile clinical symptomatology and many pathogenetic aspects not explained yet, diagnosis of this disease is often very difficult. Borreliosis may affect various human organs and systems such as movement system, nervous system (central and peripheral), skin, heart and vessels. One of the diagnostic methods for detection of microbial organisms in tissues is the histochemical staining by Warthin-Starry. Very important problem connected with this illness is the relationship between borrelial antigens and autoimmunity. PMID:17007281

Wagner, Teresa; Legatowicz-Koprowska, Marta; Prochorec-Sobieszek, Monika



[Clinico-tomographic correlations in acute pancreatitis].  


In the surgery ward from Baia Mare, in the period 1989-1997 have been operated yearly, on an average, 16-17 acute pancreatitis, out of which 8-9 were necrotic-haemorrhagic acute pancreatitis. The possibility of carrying out the computerized tomography allowed a more precise pre-surgery diagnosis and after surgery was improved observation of evolution of the inflammatory phenomena from the pancreatic zone so that the volume, the structure and the outline of the pancreas, the abdominal or pleural liquid collections and the aspect of the neighboring tissues have been correlated in dynamics, with the clinic aspect of the acute pancreatitis and the prognostic indexes. Even if the computerized tomography allowed a more correct evaluation of the patients suffering of acute pancreatitis, there have been 4-6 decreases due to this affection and its complications, the post-surgery death rate remaining at 17-21%. PMID:10422361

Lese, M; Pop, C; Brându?e, M; Achim, V; Grigorescu, D; Neme?, S



[Amebic keratitis: clinico-histopathologic case report].  


The present paper describes a case of amebic keratitis in a 63-year-old female patient, who had been wearing hard contact lenses to correct myopia. The clinical course was characterized by early superficial corneal infiltrates accompanied by a marked iritis and excruciating pain. Later a ring abscess developed, combined with a disciform infiltration of the deep central stroma and a recalcitrant superficial corneal ulcer. The disease ran a very chronic course over more than 3 months. After various conservative treatments including topical steroids, antibiotics, antimycotic, and antiviral drugs, a penetrating keratoplasty had to be performed. The histopathologic examination of the corneal button revealed many encysted amebas and a few trophozoites which were classified by direct immunofluorescence as belonging to the genus Acanthamoeba (Hartmannella). Six months after keratoplasty the eye was quit without any signs of recurrence. As far as the authors know, this is the first reported case of an amebic keratitis associated with contact lenses. PMID:6482285

Witschel, H; Sundmacher, R; Seitz, H M



[Mesenchymal chondrosarcoma (clinico-morphological study)].  


Mesenchymal chondrosarcoma was found in 11 out of 161 patients with chondrosarcoma of the bone. The assaultive nature of the disease is illustrated by the following data: the period between the manifestation of symptoms and the first visit to the doctor was 5.9 +/- 4.3 months; metastases were detected within 20.56 +/- 6.04 months and 8 patients out of 10 died within the first 5 years. Two histological structures were observed: those of the chondrosarcoma type and hemangiopericytoma-like structures formed of small atypical cells. PMID:6636625

Solov'ev, Iu N; Eremina, L A; Petrovichev, N N; Khmelev, O N; Kasumov, I V



Clinico-Hematological Study of Acutemyeloid Leukemias  

PubMed Central

Context: Acute Myeloid leukemia has been of special interest to innumerable workers in the field of cancer research since the blood and haematopoietic tissue can be easily and repeatedly sampled. Aim: To know the relative incidence of Acute myeloid leukemia among the patients referred for complete haemogram at the Department of Pathology, JJMMC, Davangere, India.To study the clinical manifestations and their correlation with various types of acute myeloid leukemia.To study the haematological profiles in acute myeloid leukemia. Settings and Design: This was a hospital based study conducted at haematology unit, Department of Pathology, JJM Medical College, Davangere, India. Materials and Method: The present study was done during the period of June 2006 to May 2008 at haematology unit department of Pathology, JJM Medical College, Davangere, India. Cases from Chigateri General Hospital, Bapuji Hospital and other private hospitals situated in and around Davangere were included for the study. The case selection was based on the clinical features and supported by laboratory evidence. Bone marrow aspiration was subsequently carried out after obtaining written consent from the patient or the guardian. Statistics: The results were expressed in percentage. Results and Conclusion: A total of 1039 patients who were referred to the Department of Haematology out of which 50 patients were diagnosed as Acute Myeloid Leukemia. The present study highlighted that light microscopic features of peripheral smear and bone marrow will still remain mainstay in the diagnosis of acute leukemias. PMID:24959452



Sulla termodinamica dei materiali con memoria  

Microsoft Academic Search

Sunto  Si espone limitandosi, per semplicità, ai corpi solidi con deformazioni infinitesime, la teoria di Coleman sulla termodinamica\\u000a dei materiali con memoria. Si considerano poi, in particolare, i corpi viscoelastici lineari e identificata l'energia libera\\u000a con l'energia potenziale interna di Volterra, si deducono, dalla termodinamica, proprietà dei coefficenti di memoria, finora\\u000a ammesse come intuitive e si ottiene una rapida dimostrazione del

Dario Graffi



Opciones de cirugía para mujeres con CDIS o con cáncer de seno

E-book para mujeres con CDIS o con cáncer de seno que pueden operarse con cirugía. Esta guía explica los tipos de cirugía de seno, como la operación para preservar el seno y la mastectomía, y ayuda a las mujeres a decidir cuál cirugía es la mejor opción para ellas.


Opciones de cirugía para mujeres con CDIS o con cáncer de seno

Contiene información sobre los tipos de cirugía de seno, como la operación para conservar el seno y la mastectomía, y ayuda a las mujeres diagnosticadas con CDIS o con cáncer de seno a decidir cuál cirugía es la más conveniente para ellas.


InterCon Travel Health: Case B  

ERIC Educational Resources Information Center

InterCon provides services to health insurers of foreign tourists who travel to the United States and Canada. Management wants to implement a new information system that will deal with several operational problems, but it is having difficulty securing the capital resources to fund the system's development. After an initial failure, the chief…

Truman, Gregory E.; Pachamanova, Dessislava A.; Goldstein, Michael A.



erators with general and specific information con-  

E-print Network

, mail order, con- signment or at wholesale are prohibited. Cottage food products must be labeled in ac- tive cottage food opera- tor, please take some time to review this guid- ance document so that you are better informed about cottage food op- eration requirements. The 2011 Florida Leg- islature enacted House

Jawitz, James W.


Google Scholar: the pros and the cons  

Microsoft Academic Search

Purpose – To identify the pros and the cons of Google Scholar. Design\\/methodology\\/approach – Chronicles the recent history of the Google Scholar search engine from its inception in November 2004 and critiques it with regard to its merits and demerits. Findings – Feels that there are massive content omissions presently but that, with future changes in its structure, Google Scholar

Péter Jacsó



Too Many Minas Spoil The Con  

E-print Network

Malfois. There was quite a frenzy of activity caused by that - eventually, given the con atmosphere, we formed rival groups, all trying to be the first to spot the real Mina de Malfois and get her autograph. I was the first one in my team to spot...



The Pros and Cons of Artificial Reefs  

NSDL National Science Digital Library

This lesson plan asks students to consider whether artificial reefs (human-made objects in the ocean or sea) are good for marine ecosystems. Students will look at pictures of artificial reefs and read articles describing the pros and cons of these structures. They will conclude by writing paragraphs explaining whether they think a new artificial reef should be created in Florida waters.


CON Advising Academic Year 2013-2014  

E-print Network

in the College of Nursing (CON). Please keep this document and refer to it before your advising appointments 401 Email: Phone: 206.296.2242 206.296.2091 Web site: requirements Know what resources are available to me that help promote academic success Reflect on my

Carter, John



E-print Network

DIVERSAS MANERAS DE GENERAR ENERGIA CON AGUA EN EL PLANETA Fernando Gilbes Santaella Departamento Renovable en PR Solar Eolica Biocombustibles Agua #12;EL PLANETA AZUL #12;EL AGUA EN LA TIERRA #12" (hydropower), que es la fuerza producida por el movimiento del agua. No genera desperdicios y no produce

Gilbes, Fernando


Programmazione (scripting) server-side con PHP  

E-print Network

1 MODULO 1 PARTE 3 Programmazione (scripting) server-side con PHP 3.c Goy - a.a. 2011 server contenuto nel cookie) Goy - a.a. 2011/2012 Programmazione Web 3 PHP: cookie - I E' possibile scrivere e leggere cookie utilizzando PHP Per scrivere un cookie, utilizzo la funzione predefinita

Goy, Anna


Programmazione (scripting) server-side con PHP  

E-print Network

1 MODULO 1 PARTE 3 Programmazione (scripting) server-side con PHP 3.d Goy - a.a. 2012 di interazione home.html ll h identif.php cancella.php cancellato.php logout.phpacquisti.php Goy - a.a. 2012/2013 Programmazione Web 5 sess_scad.html home.html - login/registrazione utente identif.php

Goy, Anna


Programmazione (scripting) server-side con PHP  

E-print Network

1 MODULO 1 PARTE 3 Programmazione (scripting) server-side con PHP 3.d Goy - a.a. 2010 di interazione home.html ll h identif.php cancella.php cancellato.php logout.phpacquisti.php Goy - a.a. 2010/2011 Programmazione Web 5 sess_scad.html home.html - login/registrazione utente identif.php

Goy, Anna


Programmazione (scripting) server-side con PHP  

E-print Network

1 MODULO 1 PARTE 3 Programmazione (scripting) server-side con PHP 3.d Goy - a.a. 2011 di interazione home.html ll h identif.php cancella.php cancellato.php logout.phpacquisti.php Goy - a.a. 2011/2012 Programmazione Web 5 sess_scad.html home.html - login/registrazione utente identif.php

Goy, Anna


Programmazione (scripting) server-side con PHP  

E-print Network

1 MODULO 1 PARTE 3 Programmazione (scripting) server-side con PHP 3.c Goy - a.a. 2010 contenuto nel cookie) Goy - a.a. 2010/2011 Programmazione Web 3 PHP: cookie - I E' possibile scrivere e leggere cookie utilizzando PHP Per scrivere un cookie, utilizzo la funzione predefinita setcookie

Goy, Anna


Programmazione (scripting) server-side con PHP  

E-print Network

1 MODULO 1 PARTE 3 Programmazione (scripting) server-side con PHP 3.c Goy - a.a. 2012 server contenuto nel cookie) Goy - a.a. 2012/2013 Programmazione Web 3 PHP: cookie - I E' possibile scrivere e leggere cookie utilizzando PHP Per scrivere un cookie, utilizzo la funzione predefinita

Goy, Anna


Programmazione (scripting) server-side con PHP  

E-print Network

1 MODULO 1 PARTE 3 Programmazione (scripting) server-side con PHP 3.d Goy - a.a. 2009 di interazione home.html ll h identif.php cancella.php cancellato.php logout.phpacquisti.php Goy - a.a. 2009/2010 Programmazione Web 5 sess_scad.html home.html - login/registrazione utente identif.php

Goy, Anna


Programmazione (scripting) server-side con PHP  

E-print Network

1 MODULO 1 PARTE 3 Programmazione (scripting) server-side con PHP 3.c Goy - a.a. 2009) Goy - a.a. 2009/2010 Programmazione Web 3 PHP: cookie - I E' possibile scrivere e leggere cookie utilizzando PHP Per scrivere un cookie, utilizzo la funzione predefinita setcookie(...): nome del cookie

Goy, Anna


Somatic cell nuclear transfer: pros and cons.  


Even though the technique of mammalian SCNT is just over a decade old it has already resulted in numerous significant advances. Despite the recent advances in the reprogramming field, SCNT remains the bench-mark for the generation of both genetically unmodified autologous pluripotent stem cells for transplantation and for the production of cloned animals. In this review we will discuss the pros and cons of SCNT, drawing comparisons with other reprogramming methods. PMID:20232594

Sumer, Huseyin; Liu, Jun; Tat, Pollyanna; Heffernan, Corey; Jones, Karen L; Verma, Paul J



Aspectos relacionados con la sexualidad y la reproducción (PDQ®)

Resumen de información revisada por expertos acerca de los factores que podrían afectar el funcionamiento sexual de las personas con cáncer. Se discuten además temás sobre la fertilidad relacionados con el tratamiento del cáncer.


Aspectos relacionados con la sexualidad y la reproducción (PDQ®)

Resumen de información revisada por expertos acerca de los factores que pueden afectar el funcionamiento sexual de las personas con cáncer. Se discuten además temas sobre la fecundidad relacionados con el tratamiento del cáncer.


Watch Globally, Think Locally CON-CAN Movie Festival  

E-print Network

CORTO TOKYO 2010 Watch Globally, Think Locally 12 18 12 19 12 20 70 CON-CAN Movie Festival CON-CAN Movie Festival Presents #12;90 COMPETITION 1 : Play Expression COMPETITION 2 : Twilight TOKYO 2010 CON-CAN Movie Festival 151-0051 4-14-4 SK 4F Tel: 03-5414-6532 E-mail : cortokyo

Kasahara, Hironori


Teaching Research Service Pros and Cons The Academic Life  

E-print Network

Pros and Cons Motivation An academic job is a multi-faceted one. On the surface, it seems that all weTeaching Research Service Pros and Cons The Academic Life: What Does a Prof Really Do? John Stockie October 3, 2011 The Academic Life 1/13 #12;Teaching Research Service Pros and Cons Outline 1 Teaching 2

Stockie, John


Gli approcci terapeutici al trattamento del dolore cronico  

Microsoft Academic Search

\\u000a La terapia del paziente con dolore cronico inizia molto prima dell’incontro con il clinico, poiché tutto ciò che ha preceduto\\u000a il primo appuntamento, in un lasso di tempo talvolta molto lungo, ha portato il paziente a una parziale presa di coscienza\\u000a ed elaborazione del proprio disagio (Ercolani 1997). Presentandosi dal clinico, il paziente tende il più delle volte a sottovalutare

Gianluca Castelnuovo; Mauro Ercolani; Mario Tavola; Daniele Rovaris; Lara Bellardita; Paola Cuzziol; Enrico Molinari


Web Spoofing: An Internet Con Game  

NSDL National Science Digital Library

The Safe Internet Programming group at the Princeton University Department of Computer Science in 1996 published a paper on the practice known as "web spoofing," through which an attacker intervenes between an end-user browsing the Web and real Web sites. The attacker sets up a shadow copy of the Web, and as users request pages from sites they will receive pages from the attacker's site instead. This process also enables attackers to gather data (possibly credit card numbers, etc.) submitted through bogus web forms. The nine-page paper describes how the con game works and suggests remedies. The article is available in PostScript, compressed PostScript, Microsoft Word, and zipped Microsoft Word format. Unfortunately, it is not available online as HTML.

Balfanz, Dirk ..; Dean, Drew.; Felten, Edward W.; Wallach, Dan S.



Cervical disc arthroplasty: Pros and cons  

PubMed Central

Background: Cervical disc arthroplasty has emerged as a promising potential alternative to anterior cervical discectomy and fusion (ACDF) in appropriately selected patients. Despite a history of excellent outcomes after ACDF, the question as to whether a fusion leads to adjacent segment degeneration remains unanswered. Numerous US investigational device exemption trials comparing cervical arthroplasty to fusion have been conducted to answer this question. Methods: This study reviews the current research regarding cervical athroplasty, and emphasizes both the pros and cons of arthroplasty as compared with ACDF. Results: Early clinical outcomes show that cervical arthroplasty is as effective as the standard ACDF. However, this new technology is also associated with an expanding list of novel complications. Conclusion: Although there is no definitive evidence that cervical disc replacement reduces the incidence of adjacent segment degeneration, it does show other advantages; for example, faster return to work, and reduced need for postoperative bracing. PMID:22905327

Moatz, Bradley; Tortolani, P. Justin



Tratamiento inmunosupresor de la miastenia gravis con tacrolimus (FK506).  

E-print Network

??La miastenia gravis es una enfermedad autoinmune mediada por anticuerpos anti-receptor de acetilcolina del músculo esquelético. Su tratamiento incluye: La timectomia y la inmunosupresión con… (more)

Abderrazek, Jamal Azem



Tiene familiares con Alzheimer? La Escuela de Medicina del Recinto de Ciencias Mdicas en colaboracin con la Universidad de Columbia  

E-print Network

¿Tiene familiares con Alzheimer? 25/1/2008 La Escuela de Medicina del Recinto de Ciencias Médicas más con Alzheimer para participar de un estudio genético. La investigación pretende encontrar genes que se encuentren relacionados a la enfermedad de Alzheimer con el propósito de aprender más sobre las

Quirk, Gregory J.


Cálculos ab initio con correlación electrónica  

NASA Astrophysics Data System (ADS)

Estamos entrando en una era donde la ortogonalidad entre las investigaciones de carácter experimental y de naturaleza teórica se irá difuminando progresivamente y la problemática a resolver quedará en escena como el único actor principal de la obra. Como premisa para una cooperación teórico-experimental de igual a igual, la metodología químico-cuántica utilizada debe ser capaz de ofrecer resultados de carácter predictivo. Sin duda, esta madurez en la metodología químico-cuántica ya la hemos alcanzado hace algunos años, tal y como muestra entre otras muchas, la labor que nuestro grupo ha realizado en el transcurso de la última década, dentro del campo de la Espectroscopía Teórica. Los estudios realizados comprenden una amplia gama de sistemas, variando tanto en tamaño como en complejidad, abordando problemáticas espectroscópicas consideradas tradicionalmente como especialmente controvertidas. Nuestra contribución científica más relevante reside en el carácter cuantitativo de las asignaciones espectroscópicas que hemos propuesto en base a resultados ab initio. Recordemos que en los años noventa los resultados ab initio solían presentar para las energías de excitación de sistemas de tamaño molecular moderado, como el benceno, errores de más de 1 eV. En comparación con el éxito relativo de los métodos semiempíricos, la frustración de la metodología ab initio quedaba todavía más patente. Los estudios que hemos presentado representan una comprensión profunda de los espectros electrónicos en sistemas orgánicos claves, mostrando el camino a seguir para obtener asignaciones espectroscópicas precisas (entre 0.1-0.2 eV). La naturaleza del método CASPT2 junto al diseño de estrategias computacionales nos ha permitido alcanzar el carácter cuantitativo con el que se caracterizan nuestras contribuciones[1,2]. Por todo ello, algunos de los trabajos publicados se consideran clásicos dentro del campo, pues en cierto modo definen el campo, y se reflejan en libros publicados recientemente. En la conferencia se analizarán ciertos pormenores de las investigaciones realizadas. El tipo de aplicaciones llevadas a cabo hasta la fecha se ilustrará mediante el estudio teórico del espectro electrónico de ciclooctatetraeno. Dando un paso más en la evolución de nuestra investigación, pretendemos en la actualidad describir, desde un formalismo teórico y al mismo nivel de exigencia, los mecanismos subyacentes que tienen lugar en las reacciones biológicas fototoinducidas, es decir, reacciones que se inician mediante la absorción de luz[3]. Como muestra de la caracterización de los procesos fotofísicos y fotoquímicos en fotobiología teórica, hemos elegido la descripción de la conversión interna ultrarrápida que tiene lugar en los cromóforos del ADN. Los estados excitados de las moléculas de los ácidos nucleicos presentan tiempos de vida media que se encuentran en el rango de sub-picosegundos, sugiriendo la presencia de un canal ultrarrápido de conversión interna, lo que normalmente se asocia en la fotoquímica contemporánea a una intersección cónica entre el estado excitado y el fundamental[4]. De esta forma nuestro ADN previene de forma eficaz posibles reacciones en el estado excitado y se revela como un excelente protector solar.

Merchán Bonete, M.


Breath Analysis Science at PittCon 2012, Orlando, Florida  

EPA Science Inventory

Breath analysis science was featured in three organized sessions at this year?s Pittsburgh Conference and Exposition, or ?PittCon 2012? ( As described in previous meeting reports, PittCon is one of the largest international conferences for analytical chem...


-okfl ^ ORNL/CON-172 Linear Harmonic Analysis of Free-  

E-print Network

-okfl ^ ORNL/CON-172 OAK RIDGE NATIONAL LABORATORY Linear Harmonic Analysis of Free- Piston. #12;ORNL/CON-172 Engineering Technology Division* LINEAR HARMONIC ANALYSIS OF FREE-PISTON STIRLING/dynamic problem that is associated with a free-piston Stirling engine (FPSE). The governing equations

Oak Ridge National Laboratory


Tratamiento cognitivo-conductual para niños mexicanos con fobia social  

Microsoft Academic Search

Participaron 17 niños, entre 7 y 12 años, con fobia social asignados aleatoriamente a 3 condiciones: (a) niños bajo el protocolo Intervención en Adolescentes con Fobia Social (IAFS; Olivares, 2005), (b) el mismo protocolo a los niños e información a sus padres sobre el trastorno, y (c) lista de espera. En evaluaciones de pretest, postest, 3 y 6 meses después,

Flor Gil-Bernal; Laura Hernández-Guzmán



Preserving con dentiality when sharing medical database the Cellsecu system  

E-print Network

containing high quality health related data. It is a gold mine for many researchers working on the healthPreserving con dentiality when sharing medical database the Cellsecu system Yu-Cheng Chiang y named Cellsecu that maintains not only the anonymity but also the con dentiality of each cell

Chen, Sheng-Wei


Control del dolor: Apoyo para las personas con cáncer

Contiene información sobre las medicinas contra el dolor para pacientes con cáncer, los planes para controlarlo, cómo hablar con su equipo de atención médica sobre el dolor que usted siente y qué hacer para controlar los efectos físicos y emocionales del mismo.



Microsoft Academic Search

Decidir si cooperar en I+D y con quien hacerlo son los primeros temas que se plantean las empresas cuando emprenden un proyecto conjunto de investigación. El trabajo profundiza en dichas cuestiones estudiando el caso de la industria española. Con una muestra de 1.653 empresas se analiza en primer lugar la independencia de la secuencia de estas deci- siones tras lo



October 6, 1997 ITER L-Mode Con nement Database  

E-print Network

October 6, 1997 ITER L-Mode Con nement Database S.M. Kaye and the ITER Con nement Database Working Group Abstract This paper describes the content of an L-mode database that has been compiled with data, and Tore-Supra. The database consists of a total of 2938 entries, 1881 of which are in the L-phase while


Phenylbutazone: a clinico-pharmacological study in rheumatoid arthritis.  

PubMed Central

A clinical trial of phenylbutazone in high dose (300 mg daily) and low dose (50 mg daily) is presented. 2. By analysis of the data by different methods, significant differences in clinical efficacy were shown between the two therapeutic regimes. 3. A relationship between the clinical effect and plasma level of phenylbutazone was demonstrated. 4. Some problems in the interpretation of plasma level-clinical effect correlates are discussed. PMID:786356

Brooks, P M; Walker, J J; Dick, W C



Cleidocranial dysplasia: clinico-radiological illustration of a rare case.  


Cleidocranial dysplasia is an autosomal dominant condition caused by mutation of RUNX2, characterized by generalized dysplasia of the bones and teeth. Affected individuals have short stature, atypical facial features, and skeletal anomalies affecting mainly the skull and clavicle. The dental manifestations are mainly delayed exfoliation of the primary teeth and delayed eruption of the permanent teeth, with multiple impacted supernumeraries, and absence of cellular cementum. The frequency of this disorder is 1 per million individuals. Here we report a rare case of CCD in a 9-year-old male patient having most of the characteristic features of this syndrome. Interestingly, disorganized dentinal tubules were found in the roots of an extracted deciduous first molar, which seems to be a unique feature not reported previously. PMID:20339249

Mohan, Ravi Prakash S; Suma, Gundareddy N; Vashishth, Shirin; Goel, Sumit



[Hereditary ovarian carcinomas: clinico-biological features and treatment].  


Hereditary ovarian cancers account for 10% of all cases. Two major syndromes with dominant autosomal transmission are identified. The most common one is breast-ovarian cancer syndrome due to BRCA1 and BRCA2 genes mutations, and the Lynch syndrome with mutated MMR genes is the other. Alterations in homologous recombination specifically observed in ovarian cancer with BRCA defects associated to Parp inhibition create a synthetic lethality of special interest. Numerous studies are in progress to explore this promising new approach. Furthermore, it seems that carcinogenesis of these two syndromes are different, suggesting alternative therapeutic options in the near future in order to improve prognosis of ovarian carcinomas. PMID:24555961

Floquet, Anne; Stoeckle, Eberhard; Croce, Sabrina; Longy, Michel; Mc Grogan, Gaétan; Barouk, Emmanuelle; Bubien, Virginie; Garbay, Delphine; Joly, Eglantine; Guyon, Frédéric



Deficit of 21 beta-hydroxylase. Clinico-functional parameters.  


The authors report the hormonal pictures of 5 young women with partial deficit of 21-beta-hydroxylase. They performed 17OH-progesterone, DHEA-S, plasma cortisol, free urinary cortisol, testosterone, ACTH and urinary 17KS assays. They then performed a suppression test by Desametazone and stimulus test by ACTH. The Authors stress the major role of 17OH progesterone, assayed in basal conditions and after ACTH stimulus, recalling the importance of early diagnosis. Authors also stress that in these patients testosterone is always significantly high. PMID:6323056

Gangemi, M; Benato, M; Guacci, A M; Meneghetti, G



Clinico- pathological profile of patients with breast diseases  

PubMed Central

Background To evaluate the spectrum of breast diseases and their association with presenting complains of patients. Methodology It was a cross sectional study conducted from 1st January 2010 – 30th December 2012. A total of 254 breast specimens of patients, who were admitted in Civil Hospital Karachi with breast complaints, were included. Specimens were collected either from mastectomy, lumpectomy or needle biopsy from the admitted patients. Informed written consent was taken from all the patients. All patients with primary breast diseases were included. Patients undergoing chemotherapy or with secondary breast disease and slides with insufficient specimen were excluded. All data was entered and analyzed through SPSS 19. Result There were 254 breast lesions, histologically diagnosed in 3 year review period. The overall mean age of patients with breast lesion was 25.18, SD?±?11.73 with a wide age range of 12–74 years. Most common cases identified are benign 191(75.3%), followed by inflammatory 30(11.8%) and malignant lesions 30(11.8%). Most patients presenting with the complain of pain have diagnosis of fibroadenoma 24 (63.2%) while patient with complain of lump also have the most common diagnosis of fibroadenoma 147 (72.8%). Conclusions Study shows that in Pakistani females, mostly encountered breast lesion was fibroadenoma. Due to lack of awareness breast diseases present lately. Awareness must be created among women to reduce the mortality and morbidity with breast lesions. Virtual slides The virtual slide(s) for this article can be found here: PMID:23659667



[Clinico-mycological study of onychomycosis in elderly patients].  


Physical examination of nails was carried out in 210 elderly patients and nail scrapings were obtained from onychomycosis suggested lesions in order to determine their causative agents, incidence and clinical characteristics. Diagnostic was confirmed by the isolation of the agents from 74 patients, mainly from toe-nails (incidence 35.2). Tinea pedis occurred in 25% of the cases and Diabetes mellitus was the most prevalent associated disease and the most frequent clinical characteristics were the thickening, the opacity and the presence of longitudinal strias in the surface of the nails. It was compared the results obtained by microscopic examination and by culture. Trichophyton rubrum was the most common dermatophyte isolated; Candida parapsilosis was dominant among Candida species. PMID:8278750

Rodríguez-Soto, M E; Fernández-Andreu, C M; Moya Duque, S; Rodríguez Díaz, R M; Martínez-Machín, G



A clinico-epidemiological study of snake bite in Nepal.  


Envenoming from snake bite is an important medical condition, frequently encountered at the emergency department of BPKIHS hospital (Dharan, Nepal). This is a retrospective study of 52 cases of suspected snake bite who presented at the department from August 1993 to November 1994. Analysis of the data showed that snake bite was more frequent between the ages of 11 to 20 years (36.7%) and 2.5 times more common in males. Fifty-seven per cent of the bites occurred between 1600 h and midnight with highest incidence (51%) occurring during the monsoon (August-October). Twenty per cent of the patients were able to identify the snake species as venomous and 90% of them presented to the hospital within 3 h of being bitten. Sixty per cent of the bites were in the lower limb. Neurotoxicity due to envenoming was recorded in nine patients (17%). No case of coagulopathy was recorded. The overall case fatality was 3.8% but mortality amongst those exhibiting signs of neurotoxicity was 22%. PMID:9803844

Hansdak, S G; Lallar, K S; Pokharel, P; Shyangwa, P; Karki, P; Koirala, S



[The interstitial organ in weightlessness: a clinico-physiologic model].  


We performed an experiment within the 1991 Austromir mission, 3 months preflight, on the 6th inflight and 4th postflight days, respectively. Primary goal was to measure changes in venous blood and plasma sound velocity (BSV, PSV) with lower body suction (LBNP). Contrasting earth-based findings, there was no increase in BSV nor PSV with LBNP inflight. Postflight, the elevation in both values was greater than expected. Taken together with LBNP data from the German 1992 Mir cosmonaut, we propose the hypothesis that the dynamics of tissue fluid exchange is profoundly influenced by m-g adaptation. A further goal of the experiment was to determine volume- and stress-sensitive hormones. The results need validation by additional flight data and might be considered as an important contribution to our understanding of the normal functioning and pathophysiology of the interstitial organ. PMID:8178523

Hinghofer-Szalkay, H; Noskov, V B



Control del dolor: Apoyo para las personas con cáncer

Libro sobre el control del dolor en pacientes con cáncer. Cubre los métodos y medicinas, así como los efectos físicos y emocionales del dolor. Es una adaptación cultural para el público de habla hispana del libro en inglés Pain Control.


20132014 Career Guide Table of ConTenTs  

E-print Network

. . . . . . . . . . . . . . . . . . . . 6 Career Decision-Making Process . . . . . . . . . . . . . . . . . . 6 Junior Year2013­2014 Career Guide #12;#12;1 #12;2 Table of ConTenTs Introduction to Career services . . . . . . . . . . . . . . . . . . . . . 3 Letter from Career Center Director . . . . . . . . . . . . . . . . . 3 Career


Con Edison Commercial and Industrial Energy Efficiency Program  

E-print Network

? Alignment & Compliance Ratings 3 Selected Local Laws and Regulations ? LL 84 - Benchmarking the Energy & Water Efficiency of Buildings ? LL 85 - NYC Energy Conservation Code ? LL 87 - Energy Audits and Retro-commissioning ? LL 88 - Lighting Upgrades... ? Con Edison C&I Energy Efficiency Team ? Program Management and Account Executives ? Lockheed Martin Team ? Marketing, Operations, Engineering and Administration ? Market Partner Network ? Con Edison Customers 6 C&I Program: Three Major...

Pospisil, D.



El objetivo fundamental del ttulo de grado en Sociologa es formar profesionales con el perfil de socilogo, con un conocimiento global en las reas relacionadas con el conocimiento cientfico de las sociedades, y con  

E-print Network

perfil de sociólogo, con un conocimiento global en las áreas relacionadas con el conocimiento científico Programas de las asignaturas: En la guía docente de cada asignatura tienes el "Programa para imprimir Sociología por la Universidad de Alicante Día de la Sociología en la UA: 14 febrero 2014 Capacitación docente

Escolano, Francisco


Tratamiento pasivo de aguas de mina con altas  

E-print Network

Tratamiento pasivo de aguas de mina con altas concentraciones de metales Resultados de ensayos en · Metodología · Resultados · Trabajos pendientes #12;Introducción Problemática de las aguas ácidas de mina 2.5 H2O Faja Pirítica Ibérica: · Mayor reserva de pirita del mundo · Aguas ácidas de mina con

Politècnica de Catalunya, Universitat


"CON-CON" assignment strategy for highly flexible intrinsically disordered proteins.  


Intrinsically disordered proteins (IDPs) are a class of highly flexible proteins whose characterization by NMR spectroscopy is complicated by severe spectral overlaps. The development of experiments designed to facilitate the sequence-specific assignment procedure is thus very important to improve the tools for the characterization of IDPs and thus to be able to focus on IDPs of increasing size and complexity. Here, we present and describe the implementation of a set of novel (1)H-detected 5D experiments, (HACA)CON(CACO)NCO(CA)HA, BT-(H)NCO(CAN)CONNH and BT-HN(COCAN)CONNH, optimized for the study of highly flexible IDPs that exploit the best resolved correlations, those involving the carbonyl and nitrogen nuclei of neighboring amino acids, to achieve sequence-specific resonance assignment. Together with the analogous recently proposed pulse schemes based on (13)C detection, they form a complete set of experiments for sequence-specific assignment of highly flexible IDPs. Depending on the particular sample conditions (concentration, lifetime, pH, temperature, etc.), these experiments present certain advantages and disadvantages that will be discussed. Needless to say, that the availability of a variety of complementary experiments will be important for accurate determination of resonance frequencies in complex IDPs. PMID:25326659

Piai, Alessandro; Hošek, Tomáš; Gonnelli, Leonardo; Zawadzka-Kazimierczuk, Anna; Ko?mi?ski, Wiktor; Brutscher, Bernhard; Bermel, Wolfgang; Pierattelli, Roberta; Felli, Isabella C



Nuevas Iniciativas con los SIG en el Municipio de  

E-print Network

parcelario #12;Mapa resultante de Calificaci�n de Suelos #12;Se cre� un CD con los mapas en formato PDF para) N�mero de Catastro de la parcela Calificaci�n de suelos (zonificaci�n) Par de Coordenadas X,Y en

Gilbes, Fernando


NEWS & NOTES Jennifer Keeney's Trio Angelico will perform four con-  

E-print Network

NEWS & NOTES Jennifer Keeney's Trio Angelico will perform four con- certs December 1-9 in Japan- tion. Catherine Baker, Lindsay Fyffe, Sarah Giron, and Kasumi Nakashiima (studio of Jennifer Keeney) also participated. Antonia Rogers (studio of Jennifer Keeney and Krystal Grauvogl (studio of Timothy

Azevedo, Ricardo


Portadores nasofaríngeos de Neisseria meningitidis en trabajadores con riesgo ocupacional  

Microsoft Academic Search

Los portadores de Neisseria meningitidis constituyen la principal fuente de infección y transmisión de la enfermedad meningocócica. Conocer su prevalencia, las características de las cepas aisladas y los factores de riesgos asociados con el estado de portador, aportan datos valiosos al control y vigilancia epidemiológica de esta entidad clínica. Para cumplimentar los objetivos propuestos se realizó un estudio transversal descriptivo

Isabel Martínez; Gustavo Sierra; Georgina Pardo; Niurka Álvarez; Marlene Armesto; Mayelín Mirabal



Quantum computing: pro and con BY JOHN PRESKILL  

E-print Network

Quantum computing: pro and con BY JOHN PRESKILL Charles C. Lauritsen Laboratory of High Energy Physics, California Institute of Technology, Pasadena, CA 91125, USA I assess the potential of quantum computation. Broad and important applications must be found to justify construction of a quantum computer; I

Preskill, John


Inclusion: The Pros and Cons--A Critical Review  

ERIC Educational Resources Information Center

The purpose of this paper was to review, analyze, and critique the pros and cons, the advantages and disadvantages, of inclusion. The methodology consisted in analyzing and comparing research findings on the benefits and costs of inclusion. Federal legislation and regulations on inclusion were examined, analyzed, and discussed. The results showed…

Savich, Carl



Teaching after Retirement: The Pros and the Cons  

ERIC Educational Resources Information Center

Having enjoyed teaching during my active career, I continued to teach summer school following retirement. Self-observed sensory and cognitive impairments, although not mentioned by students in their evaluations, induced me to consider the pros and cons of continuing to teach. My hope is that this list of benefits and problems will be of assistance…

Sommer, Robert



Teatro en Uruguay: Conversación con Jorge Pignataro Calero  

E-print Network

Cultura. Pero tiene recursos muy magros. Te doy un ejemplo, y tú que vienes de Estados Unidos, te vas a reír cuando te diga la cifra. Con la primera partida, se quiso hacer una distribución: ¡había 43.000 dólares disponibles y 192.000 dólares de...

Bravo-Elizondo, Pedro



ORNL/CON-460 The Evaluation of a 4000-Home  

E-print Network

............................................................................7 1.4.3 Geothermal Heat Pump System Model..........................................................7ORNL/CON-460 The Evaluation of a 4000-Home Geothermal Heat Pump Retrofit at Fort Polk, Louisiana the Office of Scientific and Technical Information, P.O. Box 62, Oak Ridge, TN 37831; prices available from

Oak Ridge National Laboratory


Caracterización de tintas de titanio dopadas con óxidos metálicos  

Microsoft Academic Search

Se prepararon tintas de Diisopropoxido de titanio bis(acetilacetonato) por el método sol-gel para aplicar en la elaboración de nanoestructuras mediante la técnica de escritura directa. Esta técnica permite estructurar materiales con alto índice de refracción a escala micro y nanométrica en tres dimensiones mediante extrusión, para elaborar cristales fotónicos. El tratamiento de las nanoestructuras extruidas a temperaturas elevadas para transformarlas



Emergency Factsheet for Tratando Agua Almacenada con Cloro  

E-print Network

Emergency Factsheet for Tratando Agua Almacenada con Cloro Monty C. Dozier, Profesor Asistente y Fertilidad de Suelos El Sistema Universitario Texas A&M Al tratamiento del agua potable para mejorar su contaminaciónbacteriológica del agua. Este método tambiénpuede ser usado por los propietarios de pozos de agua particulares


Null alleles for salivary Concanavalin A-binding (Con A) and Po proteins at PRB2 and PRB4 loci  

Microsoft Academic Search

Six closely linked PRP (proline-rich protein) genes code for many salivary PRPs which show frequent null variants especially. The Con polymorphism includes the different sized Con 1 and Con 2 proteins and the null Con 0 form. N-terminal amino acid sequences (60 aa) were determined on Con 1 and Con 2 proteins. From comparison of the protein sequences with those

E. A. Azen; E. Amberger



LunGradCon: The Lunar Graduate Conference  

NASA Astrophysics Data System (ADS)

Members of the Colorado Center for Lunar Dust and Atmospheric Studies (CCLDAS) initiated the Lunar Graduate Conference (LunGradCon), modeled after the highly successful Astrobiology Graduate Conference (AbGradCon). The purpose of this conference is to enhance the professional development of graduate students and early postdoctoral researchers by providing an opportunity to present and discuss scientific research in an environment of their peers. For the first two years, LunGradCon has been held as a one-day conference in conjunction with the NASA Lunar Science Institue's (NLSI) Lunar Science Forum at the NASA Ames Research Center. Activities include an invited overview talk on each of the NASA Lunar Science Institute's three main research areas (OF the Moon, ON the Moon, and FROM the Moon), submitted oral presentations from graduate students and postdoctoral researchers, and networking opportunities with established member of the lunar science community and the NLSI. In each of the first two years of LunGradCon, there have been 20-25 attendees, with about 15 of those presenting submitted talks. Each speaker received feedback forms from the other participants in order to improve on their presentation techniques. Participants also provided feedback on the conference as a whole in order to evaluate the content and provide suggestions for improvement in following years. Overall, the feedback has been extremely positive. This talk will summarize the achievements of past LunGradCons and plans for expansion of the conference to ensure a long-term positive impact on the early careers of future lunar, planetary and space science researchers.

Dove, A.; Poppe, A.; Neish, C.; Fagan, A.; Fuqua, H.; Kramer, G. Y.; Horanyi, M.



The Pros and Cons of RFID in Supply Chain Management  

Microsoft Academic Search

This paper presents the pros and cons of using Radio-Frequency IDentification (RFID) in Supply Chain Management (SCM). While RFID has a greater number of benefits than its predecessor, the bar code, it currently comes at a price that many businesses still consider prohibitive. On the one hand, RFID is advantageous because it does not require line-of-sight scanning, it acts to

Katina Michael; Luke Mccathie



Con Edison - steam operations: Supply and distribution system changes  

SciTech Connect

The abundance of low cost electric purchases and the associated reduction of Con Edison electric generation brings significant financial pressure to transfer portions of the combination steam - electric stations to the steam rate base. Concurrently, cost proportioning in dual system stations has become less favorable to steam customers. This paper details the actions taken to respond to the current electric market and firmly establish the steam supply and distribution system as efficient and reliable in a competitive energy environment.

Badali, V.P.; Ciemniecki, D.L. [Consolidated Edison Company of New York, New York, NY (United States)



Problemas elipticos con condiciones de contorno asintoticamente lineales en infinito  

E-print Network

. Arrieta 1 Rosa Pardo2 Anibal Rodr´iguez-Bernal3 Resumen Analizamos la existencia y estructura de las Steklov la norma del operador T est´e acotada uniformenente, junto con la sublinealidad de la funci´on g´ametro se aproxima a un autovalor de Steklov, la norma del operador T diverge a infinito. Este hecho es una

Rodríguez-Bernal, Aníbal


IZ-CON: an intelligent zone controller for building systems operation  

E-print Network

This paper describes the concept of an intelligent zone controller (IZ-CON) for integrated operation of building systems. IZ-CON is intended to deploy a predictive control methodology with embedded simulation capability. Thereby, the scalability...

Mahdavi, A.; Schub, M.



Métodos con información genética para abordar la complejidad del cáncer de pulmón

Se estima que 220 000 personas recibieron un diagnóstico de alguna forma de cáncer de pulmón en 2010. Es la principal causa de muertes relacionadas con el cáncer, con más de 157 000 muertes previstas en 2010.


The pathway of lectin-mediated lymphocytotoxicity by Con A-coupled Sepharose beads.  


Soluble concanavalin A (Con A) can effectively mediate nonspecific target cell lysis by cytolytic T lymphocytes (LDCC). Because Con A bound to Sepharose beads (Con A-Seph) is also effective, it has been concluded by Z. K. Ballas, W. R. Green, and C. S. Henney. (Cell. Immunol. 59, 411, 1981) that Con A-mediated "activation" of the cytolytic cell to kill in LDCC can occur without intracellular penetration of the lectin. No preincubation of either effector or target cells with Con A-Seph has been performed. Exploiting the previous finding of G. Berke (Immunol. Rev. 72, 5, 1983) that in LDCC Con A exerts its effect(s) strictly by affecting the target rather than by bridging effector and target cells and activating the effector, identical results with Con A-Seph are shown. Preincubation of Con A-Seph with the target but not with the effector cells results in substantial killing. Moreover it is shown that the ability of Con A-Seph to mediate LDCC can be attributed to free Con A dissociating from the beads (about 1%) during the assay. Evidence is presented to indicate that the dissociated Con A, not unlike free Con A, reacts with the target cells, thereby rendering them recognizable by the effector cells. It is concluded that the activity of Con A-Seph may not be taken as evidence for Con A-mediated activation of the cytolytic cell, as suggested by Ballas et al., and that the putative Con A-mediated lymphocyte activation relevant to killing still remains to be demonstrated. Evidence contradicting Con A-mediated activation of the effector and supporting the target cell modification theory has been discussed by G. Berke, V. Hu, E. McVey, and W. R. Clark (J. Immunol. 127, 776, 1981). PMID:6609003

Keren, Z; Berke, G



Global Con guration Stabilization for the VTOL Aircraft with Strong Input Coupling  

E-print Network

In this section, we present our control design method for con guration stabilization of the VTOL aircraft. HereGlobal Con guration Stabilization for the VTOL Aircraft with Strong Input Coupling Reza Olfati Trajectory tracking and con guration stabilization for the VTOL aircraft (vertical take o and landing

Sontag, Eduardo


Ventilazione non invasiva con casco o maschera facciale in pazienti immunocompromessi* Uno studio caso-controllo  

Microsoft Academic Search

Scopo dello studio: Comparare l'efficacia della ventilazione invasiva a pressione positiva (NPPV) effettuata con casco e maschera facciale in pazienti immunocompromessi con insufficienza respiratoria acuta ipossiemica (ARF). Disegno dello studio: Studio caso-controllo. Ambientazione: La terapia intensiva generale di un ospedale universitario. Pazienti: Diciannove pazienti immunocompromessi (neoplasie ematologiche (n = 8), pazienti sottoposti a trapianto d'organo (n = 8), pazienti con

Monica Rocco; Donatella Dell' Utri; Andrea Morelli; Gustavo Spadetta; Giorgio Conti; Massimo Antonelli; Paolo Pietropaoli


Accesibilidad para personas con debilidad auditiva Linux Ubuntu 10.10  

E-print Network

Accesibilidad para personas con debilidad auditiva Linux Ubuntu 10.10 ASIC ­ 18 de noviembre de 2010 Pág. 1 de 4 GUÍA DE ACCESIBILIDAD PARA PERSONAS CON DEBILIDAD AUDITIVA EN ENTORNO Linux Ubuntu 10 personas con debilidad auditiva Linux Ubuntu 10.10 ASIC ­ 18 de noviembre de 2010 Pág. 2 de 4 Utilizando el

Fernández de Córdoba, Pedro


Accesibilidad para personas con debilidad motriz Linux Ubuntu 10.10  

E-print Network

Accesibilidad para personas con debilidad motriz Linux Ubuntu 10.10 ASIC ­ 18 de noviembre de 2010 Pág. 1 de 7 GUÍA DE ACCESIBILIDAD PARA PERSONAS CON DEBILIDAD MOTRIZ EN ENTORNO Linux Ubuntu 10- get install dasher" y presione enter. #12;Accesibilidad para personas con debilidad motriz Linux

Fernández de Córdoba, Pedro


Courses: Economics (ECON) Page 291Sonoma State University 2010-2011 Catalog eCOn 321 lABOr eCOnOMiCS (4)  

E-print Network

, climate change and the valuation of environmental benefit and costs. Prerequisites: ECON 204 and 205Courses: Economics (ECON) Page 291Sonoma State University 2010-2011 Catalog eCOn 321 lABOr eCOnOMiCS (4) A study of economic and social issues in U.S. labor markets. Topics will include U.S. labor

Ravikumar, B.


Do Well, Be Well with Diabetes 2013 1 Formulario de Registro para Personas con Diabetes Formulario de Registro para Personas con Diabetes 2013  

E-print Network

Do Well, Be Well with Diabetes ­ 2013 1 Formulario de Registro para Personas con Diabetes Formulario de Registro para Personas con Diabetes ­ 2013 Si usted NO TIENE diabetes, por favor NO LLENE este sobre diabetes en el Condado de _______________. D. El código postal en mi casa es __ __ __ __ __. E


Do Well, Be Well with Diabetes 2013 1 Formulario de Conclusin para Personas con Diabetes Formulario de Conclusin para Personas con Diabetes 201  

E-print Network

Do Well, Be Well with Diabetes ­ 2013 1 Formulario de Conclusión para Personas con Diabetes Formulario de Conclusión para Personas con Diabetes ­ 201 Si usted NO TIENE diabetes, por favor NO LLENE este últimos cuatro números de mi número telefónico son __ __ __ __. C. Marque todas las clases sobre diabetes


Obtención de perfiles teóricos de elementos metálicos con velocidades macroscópicas  

NASA Astrophysics Data System (ADS)

El propósito de este trabajo es poder establecer -a partir de la modelización de perfiles de distintas especies- patrones de comparación observacional que permitan caracterizar los fenómenos físicos que están presentes en las estructuras que se observan. Para ello se resuelven las ecuaciones de equilibrio de ionización para un determinado átomo y una atmósfera de parámetros determinados. A partir de ello se definen las poblaciones para los distintos grados de ionización. Considerando distintas configuraciones e intensidades de flujos de masa se deducen la función fuente, el espesor óptico y se calculan los perfiles de las distintas líneas. Se obtuvieron perfiles teóricos de líneas del CII, CIV y del OIV para flujos entrante, saliente y pasante. La forma del perfil, las intensidades relativas entre los distintos flujos y el corrimiento Doppler da cuenta de una caracterización teórica a partir de la cual se comparará con observaciones.

Cirigliano, D.; Costa, A.; Rovira, M.


Con A-induced suppressor cells in children with acute lymphoblastic leukaemia.  

PubMed Central

The function of Con A stimulation was investigated in patients with ALL in remission and in patients with ALL in the acute phase of the disease as compared to healthy controls. Suppression of the Con A response brought about by autologous Con A-activated cells was significantly lower in ALL patients in remission (mean value 29.33%) and in the acute phase (mean value 10%) than in the controls (mean value 64.86%). Suppression of the Con A stimulation of control lymphocytes by Con A-activated homologous cells of ALL patients had a mean value of 51.65%. This was significantly higher than the suppression obtained by the same ALL cells in the autologous system and of the same order of magnitude as the suppression obtained by control Con A-activated cells on control Con A stimulation (57.67%). Suppression of the Con a response of ALL lymphocytes produced by control Con A-activated cells was 23.17% and comparable to healthy controls. These results demonstrate that the function of Con A-induced suppression is significantly lower in ALL patients. They further indicate that at least two cell types are involved in this kind of suppression in humans. PMID:6448114

Eibl, M; Krepler, P; Schmidmeier, W; Zielinski, C; Winterleitner, H



Gleevec disminuye la recidiva del cáncer en pacientes con tumor estromal gastrointestinal primario

Los resultados preliminares de un estudio clínico grande aleatorio y controlado con placebo, en pacientes con tumor estromal gastrointestinal (GIST) primario, un tipo de tumor que por lo general se encuentra en el estómago o en el intestino delgado, demostraron que los pacientes a los que se administró mesilato de imatinib (Gleevec®) luego de la extirpación total de su tumor tuvieron una probabilidad significativamente menor de padecer una recidiva del cáncer en comparación con aquellos a los que no se administró imatinib.


Identification of differentially expressed genes in Con A-activated Carp ( Cyprinus carpio L.) leucocytes  

Microsoft Academic Search

A cDNA library was constructed from the message RNA (mRNA) obtained from Con A-induced head kidney (HK) leucocytes of carp (Cyprinus carpio L.). Differential screening of the cDNA was carried out by hybridization against the total cDNA probes from normal, Con A-uninduced HK leucocytes or Con A-induced HK leucocytes of carp. The differential expression patterns of certain cDNA clones were

Z. Yin; J. Y. He; Z. Gong; T. J. Lam; Y. M. Sin



Efficacia dell'Ezetimibe in Soggetti Trattati con LDL Aferesi Selettiva.  

E-print Network

??Le Dislipidemie ereditarie costituiscono un’emergenza socio sanitaria perché sono le malattie ereditarie più frequenti e generano il 76% dei pazienti con patologia vascolare aterosclerotica precoce… (more)

Calvaruso, Silvia



Immune cascades in human intervertebral disc: the pros and cons  

PubMed Central

The unique structural hallmark of the intervertebral disc has made its central composition, the nucleus pulposus (NP), excluded from the immunologic tolerance. Consequently, the intervertebral disc is identified as an immune-privileged organ. Traditionally, local detrimental immune activities caused by NP at the lesion sites of the disc are noted as a significant factor contributing to disc degeneration. However, given the beneficial activities of immune cells in other immune-privileged sites on basis of current evidence, the degenerate disc might need the assistance of a subpopulation of immune cells to restore its structure and lessen inflammation. In addition, the beneficial impact of immune cells can be seen in the absorption of the herniated NP, which is an important factor causes the mechanical compression of nerve roots. Consequently, a modulated immune network in degenerate disc is essential for the restoration of this immune-privileged organ. Until now, the understandings of immune response in disc degeneration still rest on the harmful aspect. Further studies are needed to explore its beneficial influence. Accordingly, there are no absolutely the pros and cons in terms of immune reactions caused by NP. PMID:23696917

Sun, Zhen; Zhang, Ming; Zhao, Xu-Hong; Liu, Zhi-Heng; Gao, Yang; Samartzis, Dino; Wang, Hai-Qiang; Luo, Zhuo-Jing



Percutaneous coronary intervention in nonagenarians: pros and cons  

PubMed Central

Percutaneous coronary intervention is a mainstay in the management of symptomatic or high-risk coronary artery disease. The bulk of clinical evidence and experience underlying this fact relies, however, on relatively young patients. Indeed, few data of very limited quality are available which adequately define the risk-benefit and cost-benefit profile of coronary angioplasty and stenting in very old subjects, such as those of 90 years of age or older (i.e., nonagenarians). The aim of this review is to provide a concise, yet practical, synthesis of the available evidence on percutaneous coronary revascularization in the very elderly. The main arguments elaborated upon are to what extent we can extrapolate findings from studies including younger patients to nonagenarians, whether we should provide higher priority to prognosis or quality of life in such patients, and whether we can afford to allocate vast resources to care for such subjects in an era of financial constraints. Our review of 18 studies and 1082 patients suggest that percutaneous coronary intervention is feasible and associated with acceptable short- and long-term results in this population, which is nonetheless fraught with a high mortality risk irrespective of the revascularization procedure. Accordingly, the pros and cons of percutaneous coronary intervention should be carefully weighed when considering this treatment in nonagenarians. PMID:23610578

Biondi Zoccai, Giuseppe; Abbate, Antonio; D'Ascenzo, Fabrizio; Presutti, Davide; Peruzzi, Mariangela; Cavarretta, Elena; Marullo, Antonino G.M.; Lotrionte, Marzia; Frati, Giacomo



Five payment models: the pros, the cons, the potential.  


Among the leading strategies to reform health care is the development and implementation of new payment models. The goal is to change the way physicians, hospitals, and other care providers are paid in order to emphasize higher quality at lower costs--in other words, to improve value. In an effort to build on its health care reform activities that began in 2005, the Minnesota Medical Association convened a work group in 2010 to develop recommendations on how payment reform can best be advanced. Among the work group's output was a comparative review of five payment models with respect to how they can support a value-driven health care system. This article summarizes the pros and cons of the five models--fee for service, pay for coordination, pay for performance, episode or bundled payment, and comprehensive care or total cost of care payment. It also offers the work group's recommendations for how these models might be applied in a reformed health care system. PMID:21462667

Silversmith, Janet



Meeting Report: Breath Biomarkers Networking Sessions at PittCon 2010, Orlando, Florida  

EPA Science Inventory

The Pittsburgh Conference and Exposition, or "PittCon" (, is one of the largest international conferences for analytical chemistry and instrumentation typically attracting about 25,000 attendees and 1,000 commercial exhibitors. PittCon began in 1950 as a small sp...


Efecto del suelo en la tasa de crecimiento de especies tropicales con distribuciones contrastantes  

E-print Network

1 Efecto del suelo en la tasa de crecimiento de especies tropicales con distribuciones contribuir a limitar la distribución de las especies. Uno de ellos es la fertilidad del suelo, la que con frecuencia es menor en los bosques más húmedos. Para evaluar el posible rol de la fertilidad del suelo en la

Bermingham, Eldredge


A National Look at Postmodernism's Pros and Cons in Educational Leadership  

ERIC Educational Resources Information Center

The purpose of this article is to take a look at the pros and cons of postmodernism. It is imperative for administrators to closely examine educational theories and practices prior to instituting changes. The ability to read and digest challenging material keeps one informed and prepared to lead effectively. This paper will list the pros and cons…

Townsell, Rhodena



Bienvenidos a Columbia Dental: En Columbia Dental estamos comprometidos en proveerle con cuidado dental de altura.  

E-print Network

Bienvenidos a Columbia Dental: En Columbia Dental estamos comprometidos en proveerle con cuidado dental de altura. Columbia Dental le ofrece una amplia variedad de servicios dentales en todos nuestros departamentos especializados, incluyendo Implantes Dentales. Su primera cita en Columbia Dental será con un

Grishok, Alla


Accesibilidad para personas con debilidad visual Google Chrome 8.0.552.224  

E-print Network

Accesibilidad para personas con debilidad visual Google Chrome 8.0.552.224 ASIC ­ 13 de Diciembre de 2010 Pág. 1 de 3 GUÍA DE ACCESIBILIDAD PARA PERSONAS CON DEBILIDAD VISUAL EN GOOGLE CHROME 8 accedido a Google Chrome pulsamos en la llave inglesa y dentro de esta marcamos Opciones. Figura 1 Como

Fernández de Córdoba, Pedro


Diventa Social Media Trainer Aumenta le tue possibilit occupazionali con competenze Web 2.0 e  

E-print Network

Diventa Social Media Trainer · Aumenta le tue possibilità occupazionali con competenze Web 2.0 e marketing. Perché partecipare: · Riceverai una Formazione per diventare un Social Media Trainer formative, aiutando un membro dello staff aziendale a familiarizzare con gli strumenti Social Media. Questo

Robbiano, Lorenzo



E-print Network

1 GUIA VISUAL TRANSIN #12;2 INDICE 0.- ESTRUCTURA Y JERARQUÍA DE LA MODELACI�N CON VISUAL TRANSIN) .......................................................................................... 89 #12;3 0.- ESTRUCTURA Y JERARQUÍA DE LA MODELACI�N CON VISUAL TRANSIN BASE DE DATOS: Toda la

Politècnica de Catalunya, Universitat


Optimal Phase Con ict Removal for Layout of Dark Field Alternating Phase Shifting Masks  

E-print Network

-coloring and compaction approach that simultaneously optimizes layout and phase assignment which is based the number of phase con icts that must be removed to ensure 2-colorability of the con ict graph. We reduce-shifting mask technology with negative photoresist. It also matches very well with the requirements

Zelikovsky, Alexander


La medicina nucleare nell'analisi delle malattie cardiovascolari nei pazienti con insufficienza renale cronica  

Microsoft Academic Search

Le malattie cardiovascolari sono molto comuni nei soggetti con insufficienza renale cronica (IRC). La mortalità cardiovasco- lare nei pazienti in trattamento dialitico è 10-30 volte più alta di quella della popolazione generale. Le tecniche di medicina nucleare costituiscono un momento fondamentale nella diagnosi, nella stratificazione prognostica, nel follow-up e nella valu- tazione degli effetti della terapia in pazienti con malattia

M. Spadafora; V. Cuccurullo; P. F. Rambaldi; P. Miletto; L. Mansi



ccsd00001226 Ultracold atoms con ned in rf-induced two-dimensional trapping potentials  

E-print Network

ccsd­00001226 (version 1) : 29 Feb 2004 Ultracold atoms con#12;ned in rf-induced two atoms proposed by O. Zobay and B. M. Garraway [1]. It relies on adiabatic potentials for atoms dressed by a rf #12;eld in an inhomogeneous magnetic #12;eld. This trap is well suited to con#12;ne atoms tightly


Per: Chirapaq celebra 25 aos con un foro sobre "Derechos de los Pueblos Indgenas"  

E-print Network

Perú: Chirapaq celebra 25 años con un foro sobre "Derechos de los Pueblos Indígenas celebrará su 25 aniversario con el foro público internacional: "Derechos de los Pueblos Indígenas: Avances y la Nación Cree, ex parlamentario y miembro del Mecanismo de Expertos sobre los Derechos de los

Islas, León


Resolution of Con icts Involving Many Aircraft via Semide nite Programming  

E-print Network

of aircraft navigation and auto- mated guidance particularly easy, although recent accidents seem to have been structure of the aircraft routing system allows to set a priori guarantees on aircraft con ict geometriesResolution of Con icts Involving Many Aircraft via Semide nite Programming E. Frazzoli Z.-H. Mao y

Feron, Eric


Antibiotic susceptibility of coagulase-negative staphylococci (CoNS): emergence of teicoplanin-non-susceptible CoNS strains with inducible resistance to vancomycin.  


Coagulase-negative staphylococci (CoNS) have become increasingly recognized as important agents of nosocomial infection. One of the characteristics of CoNS is their resistance to multiple antimicrobial agents commonly used for the treatment of staphylococcal infections. CoNS strains (n?=?745) isolated from a university teaching hospital in China between 2004 and 2009 were tested for antibiotic resistance. The antibiotics were placed into three categories based on resistance levels of the CoNS strains to these antibiotics: high resistance (resistance rate >70?%), including penicillin G, oxacillin and erythromycin; medium resistance (resistance rate between 30 and 70?%), including tetracycline, clindamycin, ciprofloxacin, trimethoprim/sulfamethoxazole and chloramphenicol; and low resistance (resistance rate <30?%), including rifampicin, ceftizoxime and gentamicin. We also found that the prevalence of strains non-susceptible to teicoplanin increased from 4.5 to 6.7?% between 2008 and 2009. A one-step vancomycin agar selection experiment and subsequent population analysis revealed potentially vancomycin-resistant subpopulations that have been selected from the teicoplanin-non-susceptible strains. Vigilant surveillance of nosocomial isolates of CoNS is needed to determine their resistance to glycopeptides. PMID:21799199

Ma, Xiao Xue; Wang, En Hua; Liu, Yong; Luo, En Jie



'El teatro es un camino de autoconocimiento': Entrevista con Liuba Cid, directora teatral cubana  

E-print Network

teatral muy concreta y que fue el contacto con Eugenio Barba, el teatrista italiano. Esto delimitó muy bien, no mi camino pues yo todavía no sé qué va a pasar en mi futuro, pero sí cómo debía trabajar y hacia dónde debía enfocar mi trabajo. Algo así... mi versión de su MedeamateriaU un excelente texto. Luego trabajé con otros materiales, como Rivera despojada y Paisaje con argonautas. Precisamente mi tesis de grado fue un texto espectacular sobre la obra de Heiner Muller que se llamó "La edad de...

Bravo-Elizondo, Pedro



'El teatro me ha dejado a mí': Una entrevista con Antón Arrufat"  

E-print Network

SPRING 1999 143 "El teatro me ha dejado a mí": Una entrevista con Antón Arrufat Nancy Christoph [Antón Arrufat nació en Santiago de Cuba en 1935. Además de ser dramaturgo, es poeta y narrador. Su obra dramática incluye: El cave se investiga... con el teatro. Hace años que no escribo teatro. Recibí muy males reacciones. El teatro me creó problemas de carácter político, y dejé de escribirlo.1 Era un género que escribía con mucha facilidad, y que me gustaba hacer. Es el que menos trabajo me...

Christoph, Nancy



Persisten las diferencias de cáncer de seno en hispanas con el mismo acceso a la atención médica

Con el mismo acceso a servicios médicos, persisten las diferencias en cuanto al tamaño, el estadio y el grado del cáncer de seno en las mujeres hispanas en comparación con las mujeres blancas no hispanas.


Radioterapia extema radical en cáncer infiltrante de vejiga en pacientes geriátricos con contraindicación médica para la cirugía: experiencia institucional  

Microsoft Academic Search

Resumen  Se analiza retrospectivamente la tolerancia y el control tumoral en pacientes con cáncer infiltrante de vejiga cuya única\\u000a alternativa terapéutica radical es la radioterapia externa.\\u000a \\u000a Cuarenta y siete pacientes (3 mujeres y 44 varones), con contraindicación para cistectomía, fueron tratados con radioterapia\\u000a externa con intención curativa. Cuarenta (85%) tenían una edad al diagnóstico ? 70 años. Nueve presentaban performance status

Raúl Matute Martín; Arnaldo Alvarado Astudillo; Nuria E. Martínez Moreno; José A. Arranz Arija; Marina Gómez Espí; Dolores de la Mata Moya; Esperanza Lozano Guerra; Javier Serrano Andreu; Rafael Herranz Crespo; Manuel Felipe A. Calvo



Administracin Nacional de Aeronutica y del Espacio Descubra la relacin que tiene el espacio con usted  

E-print Network

fuego Materiales con autoiluminación MEDICINA Y SALUD Diodos emisores de luz (LED) Termómetros MEDICINA Y SALUDZONA COSTERA Búsqueda y rescate en el mar Monitoreo de inundaciones Técnicas de limpieza de


ConSurf 2010: calculating evolutionary conservation in sequence and structure of proteins and nucleic acids  

PubMed Central

It is informative to detect highly conserved positions in proteins and nucleic acid sequence/structure since they are often indicative of structural and/or functional importance. ConSurf ( and ConSeq ( are two well-established web servers for calculating the evolutionary conservation of amino acid positions in proteins using an empirical Bayesian inference, starting from protein structure and sequence, respectively. Here, we present the new version of the ConSurf web server that combines the two independent servers, providing an easier and more intuitive step-by-step interface, while offering the user more flexibility during the process. In addition, the new version of ConSurf calculates the evolutionary rates for nucleic acid sequences. The new version is freely available at: PMID:20478830

Ashkenazy, Haim; Erez, Elana; Martz, Eric; Pupko, Tal; Ben-Tal, Nir



Where's the Beef? ConAgra's Approach to Energy Sources & Efficiency in Meat Processing  

E-print Network

strategy which builds our business while preserving our natural resources. ConAgra Beef has been heavily involved in sustainable development efforts since the formal process was implemented in 1995. Throughout the beef processing operation...

Kananen, T. M.


Pliocene to recent stratigraphy of the Cuu Long and Nam Con Son Basins, offshore Vietnam  

E-print Network

The Cuu Long and Nam Con Basins, offshore Vietnam, contain sediment dispersal systems, from up-dip fluvial environments to down-dip deep-water slope and basinal environments that operated along the southern continental margin of Vietnam during...

Yarbrough, Christopher Neil




Microsoft Academic Search

Este estudio analiza el papel del aceite de soja y oliva en la rehabilitación de ratas hembras subnutri- das «in utero» y durante la lactancia. A los 20 días de edad y durante un período de 70 días, los animales sub- nutridos fueron alimentados con 3 dietas diferentes: estándar, estándar enriquecida con aceite de soja (7%) y estándar enriquecida con

Celestino González; Serafina Fernández; Ángeles Menéndez-Patterson


Interferon-?con-1 Treatment of Three Patients with Severe Glucocorticoid-Dependent Asthma  

Microsoft Academic Search

We report herein the therapeutic effect of interferon (IFN)-?con in three patients with severe persistent asthma and long-term oral glucocorticoid treatment. IFN-?con (9 ?g) administered subcutaneously thrice a week over a period of more than 24 months led to a substantial clinical improvement with regard to the number of daily asthma attacks, nighttime disturbance, emergency visits and hospitalizations. In addition,

Claus Kroegel; Nicole Bergmann; Martin Foerster; Grefachew Workalemahu; Andreas Machnik; Bettina Mock; Angelika Reissig



Quimioterapia de alta dosis prolonga en forma significativa la supervivencia en pacientes con leucemia mieloide aguda

Los resultados preliminares de un estudio clínico grande con asignación al azar de pacientes de 16 a 60 años de edad con leucemia mieloide aguda (LMA), un cáncer de la sangre y de la médula ósea, que no había sido tratada anteriormente, muestran que los pacientes que recibieron una alta dosis de daunorrubicina, un fármaco de quimioterapia disponible comercialmente, durante la terapia inicial vivieron más que los pacientes que recibieron una dosis normal del mismo fármaco.


El tratamiento con cloro es un mtodo para desinfectar un pozo de agua. Se recomien-  

E-print Network

El tratamiento con cloro es un método para desinfectar un pozo de agua. Se recomien- da cuando un sistema de agua está contam- inado con bacterias. La contaminación puede ocurrir en la instalación del exceso de lluvia entran en el pozo. Si el agua subterránea constituye en sí la fuente de bacterias, el


ConSite: web-based prediction of regulatory elements using cross-species comparison  

Microsoft Academic Search

ConSite is a user-friendly, web-based tool for finding cis-regulatory elements in genomic sequences. Predictions are based on the integration of binding site prediction generated with high-quality transcrip- tion factor models and cross-species comparison filtering (phylogenetic footprinting). By incorporat- ing evolutionary constraints, selectivity is increased by an order of magnitude as compared to single- sequence analysis. ConSite offers several unique features,

Albin Sandelin; Wyeth W. Wasserman; Boris Lenhard



Comparison of consumer exposure modelling tools. Inventory of possible improvements of ConsExpo  

Microsoft Academic Search

ConsExpo is a suitable computer software programme with mathematical\\u000amodels for assessing the exposure of consumers to chemicals in consumer\\u000aproducts. This tool can be further improved by adopting certain features\\u000afrom other existing consumer exposure modelling tools.\\u000aIn ConsExpo, different routes of exposure are taken into account, such as\\u000athe route via the skin, and through inhalation and oral

Delmaar JE; Engelen JGM van



Concetti di ipnoterapia sistemica per l'interazione con i clienti depressi e con i loro sistemi-relazionali: dalla depressione ai mondi correlati  

Microsoft Academic Search

Dalla prospettiva dell'ipnoterapia sistemica, la depressione può essere valutata come informazione sui bisogni negati e sui conflitti di lealtà. Questo lavoro mostra come le ipnoterapie focalizzate sulle competenze siano di aiuto nel lavoro con i clienti depressi per riattivare e reintegrare costruttivamente nel sistema relazionale quelle abilità dissociate a livello inconscio. Verrà descritto, attraverso un caso esemplare, il tipico procedimento

Gunther Schmidt


Estudio de los NIH señala una relación de la tomografía computarizada (TC) en la infancia con leucemia y con cáncer de cerebro más tarde

Niños y adultos jóvenes a quienes se les hicieron exploraciones muchas veces con tomografía computarizada (TC), una herramienta de diagnóstico de uso frecuente, tienen un riesgo ligeramente mayor de padecer leucemia y tumores cerebrales en la década posterior a su primera tomografía.


Evaluation of the ACT*DE*CON{sup SM} process for treating gunite tank sludge  

SciTech Connect

A test was conducted to evaluate this process for selectively removing actinides from Gunite tank sludge. Mixed waste sludge from Gunite tank W-6 was subjected to the ACT*DE*CON selective leaching process. (Nearly all the TRU content was attributed to Pu.) The sludge sample was first washed with 0.01M NaOH to remove excess sodium and nitrate in the interstitial liquid supernatant. The washed wet solids were treated with the ACT*DE*CON solvent (aqueous carbonate solution containing a chelating agent and an oxidant), using a ratio of 20 ml solvent per gram wet solids. Sludge and solvent were separated by centrifugation, and the ACT*DE*CON treatment was repeated twice. Analyses showed that 71% of the solids in the sludge were dissolved while 80% of the TRU-waste components dissolved. Low separation of the TRU-waste components from other components of the sludge mixture is indicated. Almost all the U and Ca were removed from the sludge. For sludges where most of the TRU content is Pu, the ACT*DE*CON process as tested is not effective in rendering the sludge a non-TRU waste. It is recommended that ACT*DE*CON be optimized for this specific application and that other processes using different chelating and oxidizing agents be tested. Also, the ACT*DE*CON process should be tested on TRU mixed waste in which most of the TRU elements are not Pu.

Spencer, B.B.; Chase, C.W.; Egan, B.Z.




SciTech Connect

The purpose of this document is to release, into the Hanford Document Control System, FA1/0991, Sludge Particle Separation Efficiencies for the Rectangular SCS-CON-230 Container, by M. Epstein and M. G. Plys, Fauske & Associates, LLC, June 2009. The Sludge Treatment Project (STP) will retrieve sludge from the 105-K West Integrated Water Treatment System (IWTS) Settler Tanks and transfer it to container SCS-CON-230 using the Settler Tank Retrieval System (STRS). The sludge will enter the container through two distributors. The container will have a filtration system that is designed to minimize the overflow of sludge fines from the container to the basin. FAI/09-91 was performed to quantify the effect of the STRS on sludge distribution inside of and overflow out of SCS-CON-230. Selected results of the analysis and a system description are discussed. The principal result of the analysis is that the STRS filtration system reduces the overflow of sludge from SCS-CON-230 to the basin by roughly a factor of 10. Some turbidity can be expected in the center bay where the container is located. The exact amount of overflow and subsequent turbidity is dependent on the density of the sludge (which will vary with location in the Settler Tanks) and the thermal gradient between the SCS-CON-230 and the basin. Attachment A presents the full analytical results. These results are applicable specifically to SCS-CON-230 and the STRS filtration system's expected operating duty cycles.




Con-specific neighbours may enhance compensation capacity in an invasive plant.  


Facilitation, both by inter- and intra-specific neighbours, is known to be an important process in structuring plant communities. However, only a small number of experiments have been reported on facilitation in plant invasions, especially between invasive con-specific individuals. Here, we focus on how con-specific neighbours of the invasive alien plant alligator weed affect the tolerance of alligator weed to herbivory by the introduced biological control agent, Agasicles hygrophila. We conducted greenhouse and garden experiments in which invasive plant density and herbivory intensity (artificial clipping and real herbivory) were manipulated. In the greenhouse experiment, artificial clipping significantly reduced plant biomass when plants were grown individually, but when con-specific neighbours were present in the same pot, biomass was not significantly different from control plants. Similarly, when compared to control plants, plants that were subjected to herbivory by A. hygrophila produced more biomass when grown with two con-specific neighbours than when grown alone. Real herbivory also resulted in an increased number of vegetative buds, and again when two con-specific neighbours were present this effect was increased (a 55.3% increase in buds when there was no neighbour, but a 111.6% increase in buds when two con-specific neighbours were present). In the garden experiment, in which plants were grown at high density (6 plants per pot), alligator weed fully recovered from defoliation caused by insects at levels from 20-30% to 100%. Our results indicate that the con-specific association may increase the compensatory ability to cope with intense damage in this invasive plant. PMID:20522180

Lu, X; Dai, H; Ding, J



Dermatite atopica: diagnostica in vitro  

Microsoft Academic Search

La dermatite atopica (DA) o eczema atopico viene abitualmente definita come una particolare forma di eczema ad evoluzione\\u000a cronico-recidivante con caratteristiche clinico-morfologiche e di distribuzione topografica delle lesioni peculiari per ogni\\u000a singola età, che si accompagna ad un intenso prurito e che interessa abitualmente pazienti con storia personale o familiare\\u000a di atopia.

Paolo Fabbri; Emiliano Antiga; Marzia Caproni


BriTTen fesTival ClassiC ConCerT series  

E-print Network

C ConCerT series early mUsiC series paCifiCa qUarTeT ConTempo jazz aTThe logan mUsiC aCross (Tickets/Flexible Series). oUr arTisTiC VarieTy enjoy a range of musical styles and genres, including Now is the time to buy tickets to hear your kind of music, on your schedule, at prices you'll love

Butler, Laurie J.


[Primary enuresis: 144 cases (clinico-statistical observations and therapeutic considerations].  


Of 144 cases of enuresis we have studied the distribution according with the age in which the subjects have been treated by a doctor for a first consultation, the clinical form (only night, only day, mixed), the sex. We have examined the familiarity, the associated pathology (encopresis, anorexy), the spontaneous evolution and after therapy. Authors have followed a therapeutic scheme that provides for "conditio sine qua non" a practice in the child to reduce, until suspension, the swallowing of liquids during and after the evening meal and in the previous hours, for the whole period of treatment. Cures employed: a preparation with atrapine, ephedrine (Noxenur) and a preparation of dry extract of rear hypophysis (Disipidin), given in series. Another group of subjects has been treated with mipramine. Authors have reached satisfying results by these means, they employ in any case of enuresis on condition to be over 7 years old, because, at this age, there is a more effective and constant collaboration by the subject. Presented the results of EEG and EMG, too. PMID:6634449

Paci, A; Ercolini, R; Pierini, G; Benedetti, P



Clinico-Immunological Profile of Children Infected with HIV Through Vertical Transmission, in Southern India  

PubMed Central

Background: Karnataka, being “High Prevalent State” of southern India, the HIV infection among antenatal women has crossed 1%. There are very few reports available with CD4 count and stage wise clinical spectrum among children. The clinical spectrum among HIV infected infants and children vary in different areas of the world. Hence it is important to know the spectrum of opportunistic infections and their respective CD4 count among HIV infected children of our locality. Materials and Methods: The opportunistic infections among 31 paediatric seropositive patients were evaluated. These all patients were classified as per CDC guide lines into stage I, stage II, and stage III based on CD4 counts of > 1000cells/?l, 500-999 cells/?l,<500cells/?l respectively. The opportunistic infections were diagnosed by standard laboratory investigations. Clinical spectrum presented by each stage children was documented. Results: Children in stage I were 5(16.1%),stage II 14(45.1%) and stage III 12(38.7%). Oral candidiasis (29%) was the commonest, followed by recurrent respiratory tract infection (25.8%), tubercular lymphadenitis (16.1%) and chronic diarrhoea (12.9%). Conclusion: The present study showed the children with higher CD4 count had few infections and children with lower CD4 count presented with multiple opportunistic infections. This study also showed vertical transmission as the sole mode of transmission. PMID:25120978

Bairy, Indira



[Sclerosing epithelial fibrosarcoma: a clinico-morphological evaluation of 10 cases].  


Sclerosing epithelial fibrosarcoma is a malignant mesenchymal tumor (fibroblastic class). It involved tissues of the legs and trunk in patients aged 31-59 and grew slowly as an infiltrative neoplasm during 6-18 months. Relapse occurred in 20% although no metastases were reported. Tumor consisted of epithelial fibroblasts with light cytoplasm and mononuclei. The latter showed low mitotic activity. Fibroblasts came in clusters, bands and alveolar formations sitting in the fibrous stroma. There were small areas consisting of bundles of spindle-shaped fibroblasts with oval hyperchromatic nuclei. Differentiated analysis of epithelioid fibrosarcoma may also be done by computed microscopy and immunomorphology using other tumor models consisting of light-cytoplasm epitheloid cells, mostly osteosarcoma, clear-cell renal carcinoma, melanoma, synovial sarcoma and clear-cell sarcoma of the tendon sheath and aponeurosis. PMID:20020654

Blizniukov, O P; Smirnova, E A



Infected foot ulcers in male and female diabetic patients: a clinico-bioinformative study  

PubMed Central

Background The study aimed at (i) characterizing the mode of transmission of blaCTX-M and blaTEM-1 among extended-spectrum-?-lactamase (ESBL)-producing Escherichia coli strains isolated from infected diabetic foot ulcers, and (ii) identifying the risk factors for "sex-associated multidrug resistant Gram-negative bacterial (MDRGNB)-infection status" of the ulcers. Methods Seventy-seven diabetic patients having clinically infected foot ulcers were studied in a consecutive series. The E. coli strains isolated from the ulcers were screened for blaCTX-M, blaTEM-1, armA, rmtA and rmtB during the 2-year study-period. PCR amplified blaCTX-M genes were cloned and sequenced. Enterobacterial repetitive intergenic consensus (ERIC)-PCR was used for the analysis of genetic relatedness of the ESBL-producers. Risk factors for "sex-associated MDRGNB-infection status" of ulcers were assessed. Modeling was performed using Swiss-Model-Server and verified by Procheck and verify3D programmes. Discovery Studio2.0 (Accelrys) was used to prepare Ramachandran plots. Z-scores were calculated using 'WHAT IF'-package. Docking of cefotaxime with modeled CTX-M-15 enzyme was performed using Hex5.1. Results Among 51 E. coli isolates, 14 (27.5%) ESBL-producers were identified. Only 7 Class1 integrons, 2 blaCTX-M-15, and 1 blaTEM-1 were detected. Ceftazidime and cefotaxime resistance markers were present on the plasmidic DNA of both the blaCTX-M-15 positive strains and were transmissible through conjugation. The residues Asn132, Glu166, Pro167, Val172, Lys234 and Thr235 of CTX-M-15 were found to make important contacts with cefotaxime in the docked-complex. Multivariate analysis proved 'Glycemic control at discharge' as the single independent risk factor. Conclusions Male diabetic patients with MDRGNB-infected foot ulcers have poor glycemic control and hence they might have higher mortality rates compared to their female counterparts. Plasmid-mediated conjugal transfer, albeit at a low frequency might be the possible mechanism of transfer of blaCTX-M-15 resistance marker in the present setting. Since the docking results proved that the amino acid residues Asn132, Glu166, Pro167, Val172, Lys234 and Thr235 of CTX-M-15 (enzyme) make important contacts with cefotaxime (drug) in the 'enzyme-drug complex', researchers are expected to duly utilize this information for designing more potent and versatile CTX-M-inhibitors. PMID:20070911



Demographic and Clinico-Epidemiological Features of Dengue Fever in Faisalabad, Pakistan  

PubMed Central

This cross-sectional study was carried out to explore the epidemiological and clinical features of dengue fever in Faisalabad, Pakistan during 2011 and 2012. During the study period, anti-dengue IgM positive cases were reported in the post-monsoon period during the months of August–December. Certain hotspots for the dengue infection were identified in the city that coincide with the clusters of densely populated urban regions of the city. Out of total 299 IgM positive patients (male 218 and female 81); there were 239 dengue fever (DF) and 60 dengue hemorrhagic fever (DHF) patients. There was decrease in the median age of dengue patients from 31 years in 2011 to 21.5 years in 2012 (p<0.001). Abdominal pain was seen in 35% DHF patients followed by nausea in 28.3%, epistaxis in 25% and rash in 20% patients (p<0.05). Patients reported to be suffering from high-grade fever for an average of 8.83 days in DHF as compared to 5.82 days in DF before being hospitalized. Co-morbidities were found to be risk factor for the development of DHF in dengue patients. Clinical and laboratory features of dengue cases studied could be used for the early identification of patients at risk of severe dengue fever. PMID:24595236

Raza, Faiz Ahmed; Rehman, Shafiq ur; Khalid, Ruqyya; Ahmad, Jameel; Ashraf, Sajjad; Iqbal, Mazhar; Hasnain, Shahida



Oncoplastic breast surgery: initial experience at the Centro Clinico de Estereotaxia--CECLINES, Caracas, Venezuela  

PubMed Central

Background Breast-conserving surgery (BCS) may sometimes lead to deformities in the remaining breast. Oncoplastic surgery (OPS) aims to improve our aesthetic results even in the case of major volume resections. The purpose of this study is to provide an objective evaluation of our initial experience with OPS, mainly based on the levels of satisfaction reported by both patients and surgeons. Patients and Methods This prospective study was performed at CECLINES in Caracas, Venezuela, between January 2011 and October 2012. It involved 107 consecutive patients in two groups: 52 patients with level II OPS versus 55 patients with ‘standard’ BCS (SBCS). We evaluated the level of satisfaction and cosmetic outcome at 6 and 12 months post-operation using a score from 1 (bad) to 5 (excellent). The cosmetic score was recorded during the follow-up by the surgeon, by phone calls, and photographs were reviewed by a panel of four observers. Results The participation rate in the cosmetic outcome/level of satisfaction evaluation was 100% at 6 months and 96.2% at 12 months. The average tumour size was 23 mm [standard deviation (SD): 13.5] for the OPS group versus 17.6 mm (SD: 8.3) for the SBCS group (p = 0.017). The average weight for the surgical specimen was 101 g (range: 30–512 g) in the OPS group versus 60.4 g (range: 20–135 g) in the SBCS group (p = 0.004). The OPS techniques most performed were round block 40.3% (21/52), inverted T mammoplasty 26.8% (14/52) and vertical scar mammoplasty 15.3% (8/52). Of all the patients, 51.9% (27/52) had symmetrisation procedures performed distributed according to the period of the study: 77.2% (17/22) in 2011, 56.6% (17/30) in 2012, and 18.1% (6/33) in 2013. The rate of complications was 5.7% (3/52) in the OPS group and 0% for the SBCS group (p < 0.005). The average cosmetic score at 6 months by patients in the OPS group was 4.4; patient satisfaction scores of 4 (good) and 5 (excellent) were 88.4%. In the SBCS group at 6 months, the mean score reported by patients was 4.2, with scores 4–5 being 83.4% (p = 0.644). The cosmetic score by surgeons in the OPS group at 6 months was 4.5; the surgeon satisfaction scores of 4–5 were 94.2%. In the SBCS group, the surgeons’ mean score at 6 months was 4.1, with 84.5% of scores being 4 or 5 (p < 0.005). The final cosmetic score by patients in the OPS group at 12 months was 4.5; patient satisfaction scores of 4–5 were 90.4%. In the SBCS group, the final mean score at 12 months by patients was 4.2, with 77.5% of scores being 4 or 5 (p < 0.005). The final cosmetic score by surgeons in the OPS group at 12 months was 4.5; surgeon satisfaction scores of 4–5 were 92.3%. In the SBCS group, the surgeons’ final mean score at 12 months was 4.1, with 84.5% of scores being 4 or 5 (p < 0.005). Conclusions OPS provides good satisfaction rates. An SBCS when an OPS is not indicated mostly results in good satisfaction levels and cosmetic scores. Usually, the results remain stable after 6 months. The use of OPS allows the excision of bigger lesions and surgical specimens. Symmetrisation procedures are not always required. With the appropriate patient selection, the rate of complications is low for both OPS and SBCS. PMID:25374618

Acosta-Marin, V; Acosta-Freites, V; Contreras, A; Ravelo, R; Fuenmayor, G; Marin, C; Ramirez, A; Acosta-Marin, M; Perez-Fuentes, J; Longobardi, I; Esteves, H



[Clinico-virologic analysis of the incidence of tick-borne encephalitis in the Khabarovskh region].  


In the Soviet Union the incidence of tick-borne encephalitis is the highest in the geographical and epidemiological region adjacent to the Amur River (zone of coniferous and broad-leaved forests). 60.43% of all cases fall on years of cyclic rise of the disease incidence. Strains of the tick-borne encephalitis virus can be isolated with a more significant frequency from the blood of encephalitis-sick patients and from the brain of the dead in the years of disease outbreaks. PMID:7234258

Vereta, L A; Aleksandrov, V I; Nikolaeva, S P; Vladimirova, T P; Kazantseva, S I



Clinico-pathological profile of head and neck malignancies at University College Hospital, Ibadan, Nigeria  

Microsoft Academic Search

Introduction  This retrospective study analysed head and neck malignancies seen over a 19-year period at the University College Hospital,\\u000a Ibadan.\\u000a \\u000a \\u000a \\u000a \\u000a Methodology  One thousand, one hundred and ninety two patients with head and neck malignancies were analysed according to age, gender,\\u000a topography and histology.\\u000a \\u000a \\u000a \\u000a \\u000a Results  There was an annual hospital frequency of 62 cases per year. The overall mean age for these malignancies was

Akinyele O Adisa; Bukola F Adeyemi; Abideen O Oluwasola; Bamidele Kolude; Effiong EU Akang; Jonathan O Lawoyin



Chronic thinner intoxication: clinico-pathologic report of a human case.  

PubMed Central

A 27 year old Mexican male addicted for 12 years to glue-sniffing and thinner inhalation developed neurological and behavioural disturbances which led to hospital admission and death. Autopsy disclosed diffuse cerebral and cerebellar cortex atrophy and giant axonopathy both central and peripheral. The corpus callosum was atrophic secondarily to neuron loss in the neocortex. Images PMID:7441282

Escobar, A; Aruffo, C



Evaluation of clinico-epidemiological and histopathological features of pityriasis rosea  

PubMed Central

Introduction Pityriasis rosea is a sudden-onset and self limiting disease with specific skin rash. The exact etiology is still not clear. Aim To determine epidemiological, etiological, clinical and histopathological features in pityriasis rosea (PR). Material and methods Fifty two patients (older than 18 years) with PR were included in this study. Patients were examined for epidemiological and etiological features. Biopsy specimens obtained from secondary eruptions were histopathologically evaluated with hematoxylin-eosine and immunohistochemically evaluated with CD3 and CD20 monoclonal antibodies. Results Age range of patients was 18–53, mean age was 29.3 ±9.5 and women-to-men ratio was 1.08/1. Thirty-nine (75%) patients had a history of wearing new clothes, 27 (51.9%) patients had a history of recent respiratory tract infection, 15 (28.8%) patients had a history of recent gastrointestinal infection. Eczematous changes were detected in biopsy materials by histopathological evaluation, and cellular infiltrate was positively stained with pan T-cell marker CD3 and negatively stained with B lymphocyte marker CD20 in all biopsy materials in immunohistochemical examination. Conclusions In our study, frequency of pre-disease infection and prodromal symptoms history were determined to be higher than the results of similar studies in the literature. These higher results suggest that PR may be delayed-type hypersensitivity to an infectious factor. However, positive staining of all biopsy materials with pan T lymphocyte marker CD3 supports the association with cellular immunity. We believe that more extensive studies are needed on this issue.

Ozyurek, Gaye Devrim; Cenesizoglu, Erol



Clinico-pathological significance of extra-nodal spread in special types of breast cancer  

PubMed Central

Objective To investigate the significance of extra-nodal spread in special histological sub-types of breast cancer and the relationship of such spread with prognostic parameters. Methods A total of 303 breast cancer cases were classified according to tumor type, and each tumor group was subdivided according to age, tumor diameter, lymph node metastasis, extra-nodal spread, vein invasion in the adjacent soft tissue, distant metastasis, and immunohistochemical characteristics [estrogen receptor (ER), progesterone receptor (PR) existence, p53, c-erbB-2, and proliferative rate (Ki-67)]. The 122 cases with extra-nodal spread were clinically followed up. Results An extra-nodal spread was observed in 40% (122 cases) of the 303 breast cancer cases. The spread most frequently presented in micro papillary carcinoma histological sub-type (40 cases, 75%), but least frequently presents in mucinous carcinoma (2 cases, 8%). Patients with extra-nodal spread had a high average number of metastatic lymph nodes (8.3) and a high distant metastasis rate (38 cases, 31%) compared with patients without extra-nodal spread. Conclusion The existence of extra-nodal spread in the examined breast cancer sub-types has predictive value in forecasting the number of metastatic lymph nodes and the disease prognosis. PMID:25009753

Kaygusuz, Ecmel Isik; Cetiner, Handan; Yavuz, Hulya



A functioning black adenoma of the adrenal cortex: A clinico-pathological entity  

PubMed Central

A 25-year-old woman is described who had suspected hyperfunction of the adrenal cortex. She complained of fatiguability, excessive hair growth, and attacks of swelling of the face, hands, and ankles. Moreover she had a `moon face', hypertension, a `buffalo hump', and livid striae of the loins and hypogastrium. Adrenal function tests yielded values which could not be clearly interpreted. Operation showed a `black adenoma' of the adrenal cortex on the right side. As far as it is known this is the first published case of this extremely rare lesion which was operated upon and caused nearly complete remission of the endocrine disturbance. Images PMID:4452744

Visser, J. W.; Boeijinga, J. K.; Meer, C. V. D.



Bacterial Keratitis: Perspective on Epidemiology, Clinico-Pathogenesis, Diagnosis and Treatment  

PubMed Central

Bacterial keratitis is an acute or chronic, transient or recurrent infection of the cornea with varying predilection for anatomical and topographical parts of the cornea like marginal or central. It is a potentially sight-threatening corneal infection in humans that is generally found in eyes with predisposing elements, the most common of which is contact lens wear. The epidemiological data reveals the universal occurrence of this disease. With advances in the understanding of its pathogenesis, laboratory investigations like immunohistochemistry, fluorescent microscopy, enzyme immunoassays and molecular biology, and the availability of fourth generation antibiotics, the overall visual outcome in bacterial keratitis has improved with time. Particular attention should be given to this condition as it can progress very rapidly with complete corneal destruction occurring within 24–48 hours. Early diagnosis, which is primarily clinical and substantiated largely by microbiological data, and prompt treatment are needed to minimise the possibility of permanent visual loss and reduce structural damage to the cornea. PMID:21509299

Al-Mujaini, Abdullah; Al-Kharusi, Nadia; Thakral, Archana; Wali, Upender K



Hereditary spastic paraplegia: clinico-pathologic features and emerging molecular mechanisms  

PubMed Central

Hereditary spastic paraplegia (HSP) is a syndrome designation describing inherited disorders in which lower extremity weakness and spasticity are the predominant symptoms. There are more than 50 genetic types of HSP. HSP affects individuals diverse ethnic groups with prevalence estimates ranging from 1.2 to 9.6 per 100,000 [39, 70, 77, 154, 185]. Symptoms may begin at any age. Gait impairment that begins after childhood usually worsens very slowly over many years. Gait impairment that begins in infancy and early childhood may not worsen significantly. Post mortem studies consistently identify degeneration of corticospinal tract axons (maximal in the thoracic spinal cord) and degeneration of fasciculus gracilis fibers (maximal in the cervico-medullary region). HSP syndromes thus appear to involve motor-sensory axon degeneration affecting predominantly (but not exclusively) the distal ends of long central nervous system (CNS) axons. In general, proteins encoded by HSP genes have diverse functions including axon transport (e.g. SPG30/KIF1A, SPG10/KIF5A and possibly SPG4/Spastin); endoplasmic reticulum morphology (e.g. SPG3A/Atlastin, SPG4/Spastin, SPG12/reticulon 2, and SPG31/REEP1, all of which interact); mitochondrial function (e.g. SPG13/chaperonin 60/heat shock protein 60, SPG7/paraplegin; and mitochondrial ATP6; 4) myelin formation (e.g. SPG2/Proteolipid protein and SPG42/Connexin 47); 5) protein folding and ER-stress response (SPG6/NIPA1, SPG8/K1AA0196 (Strumpellin), SGP17/BSCL2 (Seipin) [113-115], “mutilating sensory neuropathy with spastic paraplegia” due to CcT5 mutation and presumably SPG18/ERLIN2); 6) corticospinal tract and other neurodevelopment (e.g. SPG1/L1 cell adhesion molecule and SPG22/thyroid transporter MCT8); 7) fatty acid and phospholipid metabolism (e.g. SPG28/DDHD1, SPG35/FA2H, SPG39/NTE, SPG54/DDHD2, and SPG56/CYP2U1); and 8) endosome membrane trafficking and vesicle formation (e.g. SPG47/AP4B1, SPG48/KIAA0415, SPG50/AP4M1, SPG51/AP4E, SPG52/AP4S1, and VSPG53/VPS37A). The availability of animal models (including bovine, murine, zebrafish, Drosophila, and C. elegans) for many types of HSP permits exploration of disease mechanisms and potential treatments. This review highlights emerging concepts of this large group of clinically similar disorders. For recent review of HSP including historical descriptions, differential diagnosis, and additional references see [78]. PMID:23897027

Fink, John K.



Clinico-radiologic characteristics of long-term survivors of diffuse intrinsic pontine glioma  

PubMed Central

Diffuse intrinsic pontine glioma (DIPG) is the deadliest central nervous system tumor in children. The survival of affected children has remained poor despite treatment with radiation therapy (RT) with or without chemotherapy. We reviewed the medical records of all surviving patients with DIPG treated at our institution between October 1, 1992 and May 31, 2011. Blinded central radiologic review of the magnetic resonance imaging at diagnosis of all surviving patients and 15 controls with DIPG was performed. All surviving patients underwent neurocognitive assessment during follow-up. Five (2.6%) of 191 patients treated during the study period were surviving at a median of 9.3 years from their diagnosis (range, 5.3 to 13.2 years). Two patients were younger than 3 years, one lacked signs of pontine cranial nerve involvement, and three had longer duration of symptoms at diagnosis. One patient had a radiologically atypical tumor and one had a tumor originating in the medulla. All five patients received RT. Chemotherapy was variable among these patients. Neurocognitive assessments were obtained after a median interval of 7.1 years. Three of four patients who underwent a detailed evaluation showed cognitive function in the borderline or mental retardation range. Two patients experienced disease progression at 8.8 and 13 years after diagnosis. A minority of children with DIPG experienced long-term survival with currently available therapies. These patients remained at high risk for tumor progression even after long follow-ups. Four of our long-term survivors had clinical and radiologic characteristics at diagnosis associated with improved outcome. PMID:23813229

Jackson, Sadhana; Patay, Zoltan; Howarth, Robyn; Pai Panandiker, Atmaram S.; Onar-Thomas, Arzu; Gajjar, Amar; Broniscer, Alberto



A new clinico-pathological classification system for mesial temporal sclerosis  

Microsoft Academic Search

We propose a histopathological classification system for hippocampal cell loss in patients suffering from mesial temporal\\u000a lobe epilepsies (MTLE). One hundred and seventy-eight surgically resected specimens were microscopically examined with respect\\u000a to neuronal cell loss in hippocampal subfields CA1–CA4 and dentate gyrus. Five distinct patterns were recognized within a\\u000a consecutive cohort of anatomically well-preserved surgical specimens. The first group comprised

Ingmar Blümcke; Elisabeth Pauli; Hans Clusmann; Johannes Schramm; Albert Becker; Christian Elger; Martin Merschhemke; Heinz-Joachim Meencke; Thomas Lehmann; Andreas von Deimling; Christian Scheiwe; Josef Zentner; Benedikt Volk; Johann Romstöck; Hermann Stefan; Michelle Hildebrandt



Abdominal angiostrongyliasis in Nicaragua: a clinico-pathological study on a series of 12 cases reports.  


A retrospective study was done to determine the presence of abdominal angiostrongyliasis in Nicaragua. Twelve cases of this parasitic disease were found among 48 visceral specimens: small intestine, liver and testes. The patients with intestinal lesions presented symptoms of an acute abdomen, and in some instances, a tumor-like mass was palpated in the lower right quadrant. A thickening of the intestinal wall accompanied by necrosis and perforation were the most important macroscopic findings. One patient with hepatic localisation of Angiostrongylus costaricencis displayed a clinical picture of visceral larva migrans-like syndrome. The chief laboratory findings were leukocytosis and eosinophilia. The histopathological examination showed granulomas and heavy eosinophilic infiltration around the eggs and larvae of A. costaricencis. Also, an adult worm was seen in one biopsy. PMID:1822656

Duarte, Z; Morera, P; Vuong, P N



[Clinico-epidemiological analysis of choroidal melanoma in Split Area, Croatia].  


Choroidal melanoma is the most common primary intraocular malignant tumour in adults. The aim of the study was to examine epidemiological characteristics of choroidal melanoma in Split-Dalmatia County from 1990 to 2009. In this retrospective study, data on 46 patients from medical documentation of the University Department of Ophthalmology, Split University Hospital Center, were analyzed. According to 2001 census, the Split-Dalmatia County population was 467,676 inhabitants. The incidence of choroidal melanoma was 0.49 per 100,000 inhabitants, which is somewhere in the middle of the incidence between south and north Europe. Choroidal melanoma most commonly appeared in the 7th decade of life. The average dimensions of choroidal melanoma (basis x height) were 13.4 x 8.0 mm. Histopathologic findings according to Callender classification showed the following types of melanoma: epithelioid cell type 8%, spindle cell type 40%, and mixed type 52%. The most common forms of therapy were enucleation 47.8% and brachytherapy 28.3%, which means that patients presented relatively late when choroidal melanoma advanced in size. The Split-Dalmatia County has 1/10 of the Croatian population, so it could be supposed that approximately 25 new cases of malignant melanoma of the choroid are discovered annually in Croatia. For early detection of the disease, regular and complete checkups are necessary, especially in presbyopic population. Study results enabled better evaluation of the disease and better planning of ophthalmologic service in the treatment of this serious eye disease. PMID:22359894

Ivanisevi?, Petar; Boji?, Lovro; Tomi?, Snjezana; Bucan, Kajo; Ivanisevi?, Milan; Lesin, Mladen; Plestina-Borjan, Ivna; Stani?, Robert



Endophthalmitis patients seen in a tertiary eye care centre in Odisha: A clinico-microbiological analysis  

PubMed Central

Background & objectives: Geographical variations are known to influence different aspects of endophthalmitis. We report the epidemiological, clinical and microbiological profile of patients with infectious endophthalmitis presented to a tertiary eye care centre in Odisha, India, and compare the results with published reports from other parts of India. Methods: Retrospective review of medical records of 107 patients, seen between December 2006 and January 2009 was done. All patients had undergone parsplana vitrectomy with intraocular antibiotics and the management was based on microbiological analysis of the vitreous fluid. Results: Forty six (43.0%) patients had post-operative (PO), 43 had post-traumatic (PT) and 18 (16.8%) had endogenous (EG) endophthalmitis. Males were predominant in all three types of endophthalmitis. Significantly younger individuals constituted PT group. While culture established microbial diagnosis in 45 patients (42%), direct microscopy was positive in 38 patients (35.5%). Fungal aetiology was found in 13 patients (PO-7, PT-4, EG-2) and bacteria accounted for 32. Similar to studies from north, central and south India, fungi and Gram-negative bacteria accounted for a large number of PO endophthalmitis cases. Two PT patients had polymicrobial infection. All Gram-positive bacteria were susceptible to vancomycin. Susceptibility to ceftazidime was variable among the Gram-negative bacteria. Best corrected visual acuity (BCVA) at presentation was less than 20/200 in majority (93%) of the patients. While the treatment outcome was variable in fungal and sterile endophthalmitis, the BCVA was either unchanged or improved in 100 per cent of bacterial endophthalmitis patients. Interpretation & conclusions: The spectrum of infection and outcome of infectious endophthalmitis in Odisha was similar to other parts of the country. Fungi and bacteria were involved in all three types of endophthalmitis. Empirical use of standard intravitreal therapy is recommended while emphasizing on vitreous biopsy for culture and sensitivity whenever possible. PMID:24604043

Sharma, Savitri; Padhi, Tapas R.; Basu, Soumyava; Kar, Sarita; Roy, Arvind; Das, Taraprasad



[Biological evaluation of new hydroxyapatite endodontic cement in vivo. Histopathological and clinico-pathological observation].  


Histopathological observations of vital human and monkey dental pulp were performed to evaluate biologically a new root canal filling material APC containing hydroxyapatite. Experimental materials were divided into the following 3 groups. Group 1. Direct application to pulp wound (monkey teeth), 30 and 90 days. Group 2. Direct application to pulp wound (human teeth), 8-477 days. days. Group 3. Root canal filling on pulp stump (human teeth), 7-461 days. After extraction, the experimental teeth were fixed, demineralized, dehydrated and embedded in celloidin, they were prepared as thin sections and submitted to hematoxylin-eosin staining. Light microscopic observations were then made of them. After fixing, some specimens were embedded in resin and prepared in ultra thin sections before being triple stained with tannic acid-ethanol uranium-lead. They were submitted to observation under a HITACHI H-600 transmission electron microscope (TEM). Element analysis was performed on some unstained sections by means of energy dispersive X-ray analysis with a Kevex 7000A. Results 1. Application of APC to monkey dental pulp had no inhibiting effects on the healing progressed, the formation of regeneration hard tissue was observed. APC is believed to be biocompatible with dental pulp tissues. 2. Of the total of 50 cases in which APC was applied to human dental pulp, by the end of the experiment, 42 had occurred no symptoms of any kind. Broked down further, this means 23 (92%) of 25 cases in Group 2 and 19 (76%) of 25 cases in Group 3. Of the 25 cases in Group 2, 24 (96%) were evaluated as clinically good, none (0%) as fair, and 1 (4%) as unsatisfactory. Of the 25 cases in Group 3, 22 (88%) were evaluated as clinically good, 2 (8%) as fair, and 1 (4%) as unsatisfactory. Histopathologically, various pathological findings occurred in both groups of experimental materials. In the early stage, hyperemia, hemorrhage, round-cell infiltration, suppurative inflammation, and resorption of dentin in chamber walls were observed. By the thirtieth postoperative day, pulp cicatrization, formation of new hard tissue, and apposition of dentin on chamber walls were observed. TEM investigation of round-cell infiltration, observed in both group, revealed incursions of hydroxyapatite and bismuth in the macrophages. The tendency for hard tissue newly generated has began on 73 days in Group 2 and on 32 days in Group 3. This finding was made somewhat earlier in Group 2. Thereafter, dental pulp continued in a healthy condition.(ABSTRACT TRUNCATED AT 400 WORDS) PMID:2561410

Yamaguchi, K



Clinico-epidemiological trends of leprosy in Himachal Pradesh: a five year study.  


This retrospective study was done to determine the epidemiological and clinical profile of leprosy patients in a tertiary care centre, Indira Gandhi Medical College, Shimla, Himachal Pradesh, India. In this study, we included patients registered from January 2004 to December 2008 with the urban leprosy clinic of our tertiary care centre. Data regarding demographic details, clinical features, treatment and complications was extracted from the records of the leprosy clinic. 163 patients attended the clinic during this period with male to female ratio of 3:1. Majority of patients (47.8%) were in the middle age group (20-40 years) and 13.49% patients were < 20 years of age. In the clinical disease spectrum, 53.98% patients were in the borderline spectrum followed by lepromatous leprosy (33.12%) and polar tuberculoid leprosy (5.52%). Pure neuritic and indeterminate leprosy accounted for 3.06% each. Histoid lesions were present in 7.4% of lepromatous leprosy patients. 9.2% patients had definite history of contact in the family or neighborhood. 28.22% patients were immigrants either from Nepal or adjoining states of Himachal Pradesh. Epidemiological studies and contact tracing can decrease the disease burden and morbidity associated with the disease. Multidrug therapy (MDT) helps preventing and reducing the disease progression, severity and disabilities. PMID:20704072

Jindal, N; Shanker, V; Tegta, G R; Gupta, M; Verma, G K



Clinico-Immunological Analysis of Eggplant (Solanum melongena) Allergy Indicates Preponderance of Allergens in the Peel  

PubMed Central

Background Eggplant (Solanum melongena L.) is known to cause food allergy in some Asian countries but detailed studies on eggplant allergy are lacking. Objective The objective is to investigate sensitization to different parts of eggplant fruit, and detection of the allergens. Methods Six eggplant-allergic subjects were assessed for sensitization to eggplant (peel/pulp, and raw/cooked) by skin prick test, allergen-specific IgE, and immunoblots. Allergens were analyzed for glycoprotein nature by staining/lectinoblots, and in vitro stability in simulated gastric fluid. Results All the eggplant-sensitized subjects showed positive skin prick test with peel, pulp, raw, and cooked eggplant extracts; allergen-specific IgE to all these was positive. Raw eggplant contains 5 allergens in the range 36-71 kD. Most allergens are localized in the eggplant peel (9 allergens; 26-71 kD range) than the pulp (3 allergens; 52-71 kD); among these, the 26, 28, 36, and 71 kD allergens seem to be heat-stable. The 43, 45, 64, and 71 kD allergens are detected as glycoproteins; the 26, 64, and 71 kD allergens are stable displaying retention of IgE-binding ability in simulated gastric fluid digestion. Conclusions Eggplant is a multiallergenic vegetable in the context of presence of allergens in all edible parts of eggplant having preponderance in the peel. PMID:23283148



The nephrotic syndrome in the elderly: clinico-pathological correlations in 317 patients  

Microsoft Academic Search

We have used the Medical Research Council's Glomerulonephritis (GN) registry to review the clinicopathological findings in a large group (317) of patients over 60 years of age and presenting with the nephrotic syndrome. A wide variety of histological appearances were seen to underlie this clinical diagnosis with the most frequent being membranous nephropathy (36.6%), minimal change nephrotic syndrome (11.0%) and

Paul A. Johnston; June S. Brown; Alex M. Davison



Epithelial toll-like receptor 9 signaling in colorectal inflammation and cancer: Clinico-pathogenic aspects  

PubMed Central

Toll-like receptors (TLRs) recognize specific motifs which are frequently present in bacteria, fungi, prokaryotes and viruses. Amongst TLRs, TLR9 can be activated by such bacterial or viral DNA fragments, immunoglobulin-DNA complexes or synthetic oligonucleotides, which all contain unmethylated cytosine-guanine nucleotide sequences (CpGs). Emerging data indicate that TLR9 signaling has a role in, and may influence, colorectal carcinogenesis and colonic inflammation. CpGs are classified into three groups according to their influence on both the antigen-specific humoral- and cellular immunity, and the production of type 1 interferons and proinflammatory cytokines. TLR9 activation via CpGs may serve as a new therapeutic target for several cancerous and various inflammatory conditions. Due to its probable anti-cancer effects, the application possibilities of TLR9-signaling modulation may be extremely diverse even in colorectal tumors. In this review we aimed to summarize the current knowledge about TLR-signaling in the pathogenesis and therapy of inflammatory bowel diseases and colorectal cancer. Due to the species-specific differences in TLR9 expression, however, one must be careful in translating the animal model data into the human system, because of the differences between CpG-oligodeoxynucleotide-responsive cells. TLR9 agonist DNA-based immunomodulatory sequences could also represent a promising therapeutic alternative in systemic inflammatory conditions and chronic colonic inflammations as their side effects are not significant. PMID:23864774

Furi, Istvan; Sipos, Ferenc; Germann, Tiana M; Kalmar, Alexandra; Tulassay, Zsolt; Molnar, Bela; Muzes, Gyorgyi



A clinico-epidemiological study of ulcerative sexually transmitted diseases with human immunodeficiency virus status  

PubMed Central

Introduction: Genital ulcerative diseases are a major public health problem. The advert of human immunodeficiency virus (HIV)/AIDS over the past 25 years has deepened the scope of morbidity, mortality, and various forms of clinical presentations of sexually transmitted diseases (STDs). Materials and Methods: A total of 50 cases having Genital ulcerative diseases and STD reporting to STD clinic during the period of the year from November 2005 to December 2006 were included and detailed history and clinical examination were carried out and provisional diagnosis is made. Laboratory confirmation of clinically diagnosed cases was done using laboratory tests such as S. HIV, venereal disease research laboratory, Tzanck smear, gram stain, and Giemsa stain. Result: In the present study, the incidence of herpes progenitalis was (38%) followed by primary syphilis (32%), chancroid (26%), lymphogranuloma venereum (02%), and genital scabies (02%). HIV sero-positivity was detected in 12% (n = 6) cases. Conclusion: HIV was found to be more common among genital ulcer disease patients, especially syphilis and genital herpes. PMID:24958991

Mehta, Bhavesh



Tumor estrogen content and clinico-morphological and endocrine features of endometrial cancer  

Microsoft Academic Search

Objectives. To compare estrogen concentrations in endometrial cancer tissue with those in macroscopically normal endometrium and with certain morphological characteristics of the tumor and endocrine parameters in patients. Methods. The estradiol content was evaluated by radioimmunoassay after homogenization and extraction in 78 adenocarcinomas (61 from postmenopausal patients). Results. Higher concentrations of estradiol in tumor tissue samples than in macroscopically normal

L. M. Berstein; A. E. Tchernobrovkina; V. B. Gamajunova; A. J. Kovalevskij; D. A. Vasilyev; O. F. Chepik; E. A. Turkevitch; E. V. Tsyrlina; S. J. Maximov; L. A. Ashrafian; J. H. H. Thijssen



High-resolution genomic profiles define distinct clinico-pathogenetic subgroups of multiple myeloma patients.  


To identify genetic events underlying the genesis and progression of multiple myeloma (MM), we conducted a high-resolution analysis of recurrent copy number alterations (CNAs) and expression profiles in a collection of MM cell lines and outcome-annotated clinical specimens. Attesting to the molecular heterogeneity of MM, unsupervised classification using nonnegative matrix factorization (NMF) designed for array comparative genomic hybridization (aCGH) analysis uncovered distinct genomic subtypes. Additionally, we defined 87 discrete minimal common regions (MCRs) within recurrent and highly focal CNAs. Further integration with expression data generated a refined list of MM gene candidates residing within these MCRs, thereby providing a genomic framework for dissection of disease pathogenesis, improved clinical management, and initiation of targeted drug discovery for specific MM patients. PMID:16616336

Carrasco, Daniel R; Tonon, Giovanni; Huang, Yongsheng; Zhang, Yunyu; Sinha, Raktim; Feng, Bin; Stewart, James P; Zhan, Fenghuang; Khatry, Deepak; Protopopova, Marina; Protopopov, Alexei; Sukhdeo, Kumar; Hanamura, Ichiro; Stephens, Owen; Barlogie, Bart; Anderson, Kenneth C; Chin, Lynda; Shaughnessy, John D; Brennan, Cameron; Depinho, Ronald A



High-resolution genomic profiles define distinct clinico-pathogenetic subgroups of multiple myeloma patients  

Microsoft Academic Search

Summary To identify genetic events underlying the genesis and progression of multiple myeloma (MM), we conducted a high-resolu- tion analysis of recurrent copy number alterations (CNAs) and expression profiles in a collection of MM cell lines and out- come-annotated clinical specimens. Attesting to the molecular heterogeneity of MM, unsupervised classification using non- negative matrix factorization (NMF) designed for array comparative

Daniel R. Carrasco; Giovanni Tonon; Yongsheng Huang; Yunyu Zhang; Raktim Sinha; Bin Feng; James P. Stewart; Fenghuang Zhan; Deepak Khatry; Marina Protopopova; Alexei Protopopov; Kumar Sukhdeo; Ichiro Hanamura; Owen Stephens; Bart Barlogie; Kenneth C. Anderson; Lynda Chin; John D. Shaughnessy; Cameron Brennan; Ronald A. DePinho



[Clinico-histologic-morphometric correlations in pulmonary arteries among patients with heart malformations ].  


To improve the evaluation of grades of pulmonary vascular lesions in congenital heart malformations, we studied the extent to which there is a measurable relationship between pressure conditions in the pulmonary circulation and the area of the media in small and medium-sized pulmonary arteries, and the possibility of a correlation between the subjective evaluation of grades of hypertensive pulmonary vascular lesions according to Heath and Edwards (1958). Material and methods. The lungs in 68 children (mean age, 22.7 months) with congenital malformations of the heart or great vessels resulting in pulmonary hypertension were examined. The lungs were fixed in a 4% formalin solution passed via the trachea under a constant filling pressure of 150 cm H2O. Peripheral as well as central tissue was removed from all lobes of the lungs; the specimens were stained with Elastica-van Gieson. The extent of hypertensive pulmonary vasculopathy was staged, without knowledge of the pressure conditions, according to the grading system developed by Heath and Edwards. The diameter and the area of all muscular arteries with diameters smaller or larger than 100 micron were measured using a semiautomatic measurement device for quantitative morphometric analysis (MOP/AM 01). Cardiac catheter values were available for all cases. The quotient of systolic pressures in the pulmonary artery and the aorta was taken as the measure of hemodynamic conditions in the pulmonary circulation. The Pearson-Bravais correlation coefficient (r) was computed from the respective area quotient and the corresponding pressure values. In addition, the coefficient of determination (r2) and regression functions were determined. Results. A linear correlation (r = 0.70) exists between the pressure quotient (Psyst. pulm. art./ Psyst. aorta) and the vessel area quotient (media area/total area). The correlation is expressed by the following functions: x = 1.89 y - 0.08 y = 0.26 x + 0.24 Using the Heath and Edwards grading, the following frequencies were obtained: Grade 0: 21, Grade I: 7, Grade II: 16, Grade III: 15, Grade IV: 6, and 3 children were undeterminable. No relationship exists between the grades and certain heart malformations. In spite of the fact that hypertensive vasculopathy becomes progressively more severe as the child grows older, we found four cases of Grade IV in children under the age of one. On the whole, a comparison of the measured area quotients and the Heath and Edwards grading showed a good correlation. Although we considered only pressure quotients and no other hemodynamic parameters, conclusions can be drawn about the operability of congenital heart malformations based on these findings. Using measured pressure values, the morphologic state of the pulmonary arteries can be approximately evaluated. PMID:7122326

Fischbach, H; Hoffmeister, H M; Hoffmeister, H E; Apitz, J; Schmidt, C



Clinico-epidemiological features of snakebite: a study from Eastern Nepal.  


We studied 604 suspected snakebite cases seen at the peripheral snakebite treatment centre, Damak, Eastern Nepal from January to December 2000 using pre-designed proforma. Seventy-five per cent of the patients were in the age group 11-40 years. The common victims were farmers (44.2%) and housewives (31.7%). The bite was commonly encountered during farming (29.4%), working in the field (16.2%), walking (13.7%) and feeding cattle (9.2%). Sixty-five per cent were bitten during outdoor and agriculture related activities. Bite during sleep was recorded in 7%: 62% had sustained bite in lower limb. Forty-two per cent of the victims arrived at the treatment centre within 2 hours of being bitten. Fourteen patients arrived 7 hours after being bitten and six were dead on arrival. A common local practice (seen in 56.7%) was to eat chillies to confirm envenomation. Application of a tourniquet, often multiple, was the common (90%) first aid measure. Neurotoxicity was present in 11% (n=66) of the victims. Five had local features of envenomation. No case of coagulopathy was recorded. Reaction to anti-snake venom was noticed in 28.16% (n=20). Two patients died during treatment. Mortality among patients with features of neurotoxicity was 3%. PMID:14959965

Sharma, Sanjib Kumar; Koirala, Sekhar; Dahal, Gehraj; Sah, Chandra



An integrated clinico-metabolomic model improves prediction of death in sepsis  

PubMed Central

Sepsis is a common cause of death, but outcomes in individual patients are difficult to predict. Elucidating the molecular processes that differ between sepsis patients who survive and those who die may permit more appropriate treatments to be deployed. We examined the clinical features, and the plasma metabolome and proteome of patients with and without community-acquired sepsis, upon their arrival at hospital emergency departments and 24 hours later. The metabolomes and proteomes of patients at hospital admittance who would die differed markedly from those who would survive. The different profiles of proteins and metabolites clustered into fatty acid transport and ?-oxidation, gluconeogenesis and the citric acid cycle. They differed consistently among several sets of patients, and diverged more as death approached. In contrast, the metabolomes and proteomes of surviving patients with mild sepsis did not differ from survivors with severe sepsis or septic shock. An algorithm derived from clinical features together with measurements of seven metabolites predicted patient survival. This algorithm may help to guide the treatment of individual patients with sepsis. PMID:23884467

Langley, Raymond J.; Tsalik, Ephraim L.; van Velkinburgh, Jennifer C.; Glickman, Seth W.; Rice, Brandon J.; Wang, Chunping; Chen, Bo; Carin, Lawrence; Suarez, Arturo; Mohney, Robert P.; Freeman, Debra H.; Wang, Mu; You, Jinsam; Wulff, Jacob; Thompson, J. Will; Moseley, M. Arthur; Reisinger, Stephanie; Edmonds, Brian T.; Grinnell, Brian; Nelson, David R.; Dinwiddie, Darrell L.; Miller, Neil A.; Saunders, Carol J.; Soden, Sarah S.; Rogers, Angela J.; Gazourian, Lee; Fredenburgh, Laura E.; Massaro, Anthony F.; Baron, Rebecca M.; Choi, Augustine M.K.; Corey, G. Ralph; Ginsburg, Geoffrey S.; Cairns, Charles B.; Otero, Ronny M.; Fowler, Vance G.; Rivers, Emanuel P.; Woods, Christopher W.; Kingsmore, Stephen F.



[Effect of microsomal monooxygenase inductor zixoryn on clinico-immunologic indicators in allergologic patients].  


Zixorine, an inducer of microsomal monoxygenases, can effectively be used for the treatment of patients with allergic dermatoses. It has been established that zixorine makes the NBT-test and the IgE content in the blood serum of these patients return to normal. PMID:3576481

Lozovo?, V P; Vol'skii, N N; Nepomniashchikh, V M; Tananko, E M; Nosikova, T A



Menstrual Irregularities with excessive blood loss: a Clinico-Pathological Correlation  

Microsoft Academic Search

Objective: To evaluate various histo-pathological features in endometrial curettings of patients complaining of menstrual irregularities with excessive blood loss and correlating them with clinical presentations. Methods: A total of 260 endometrial curettings were obtained by Dilatation and Curettage done at the Department of Gynecology and Obstetrics, Railway Hospital, Rawalpindi. All the preserved specimens were processed under standard conditions at the

Muhammad Muzaffar; Khalida Adeeb; Khanum Akhtar; Shahina Yasmin; Wasim Iqbal; Masood Ahmed Khan


Effect of Diuretics on Salivary Flow, Composition and Oral Health Status: A Clinico-biochemical Study  

PubMed Central

Background: Saliva represents an increasingly useful tool of diagnosis. Several factors such as salivary flow rates (SFRs) (unstimulated and stimulated) (U and S), pH, buffering capacity and consistency can be altered due to several disease processes or medications prescribed for various diseases. Alterations of SFRs, pH, buffering capacity and various ion concentrations can influence the pathogenesis of some of the oral diseases. Aim: Evaluation of the effect of diuretics on oral health status with regard to SFRs (U and S), pH, buffering capacity, total protein content, various ion concentrations and oral mucosal lesions. Subjects and Methods: A total of 100 patients were categorized into test group and control group based on usage of diuretics. Unstimulated and stimulated saliva were collected and evaluated for flow rates. Salivary pH was measured using pH meter. Buffering capacity was measured using Aranha's technique. Salivary Na+, K+ and Cl? concentrations were measured using electrolyte analyzer CORNLEY ACCULYTE-3P in ion-selective electrode method. Salivary total protein content was measured by spectrophotometric method. Dental Caries and periodontal status were measured by using decayed, missing, filled teeth index and Russell's periodontal index respectively. Oral mucosal examination was carried out to identify the mucosal lesions. Results: The obtained results were subjected to statistical analysis using Statistical package for social sciences software (SPSS), version 16, IBM Company by Chi-square test and unpaired t-test. Highly significant P for alterations of SFR/U (P < 0.001), SFR/S (P < 0.001), pH (P < 0.001), Na+ concentration (P < 0.001), buffering capacity (P < 0.001) and moderate significance for Cl? concentration (P < 0.01) were found. Alterations of total protein (P = 0.14) and K+ (P = 0.65) concentrations were not statistically significant. High prevalence was found for caries (P < 0.01), periodontal status (P < 0.001) and mucosal lesions (P < 0.01). Conclusion: Our study shows that diuretic medication significantly reduces SFRs (xerostomia) and alters salivary composition which may have an impact on the incidence of dental caries, periodontal diseases and mucosal lesion formation. PMID:25221702

Prasanthi, B; Kannan, N; Patil, RR



Aortic valve regurgitation and the congenitally bicuspid aortic valve: a clinico-pathological correlation  

Microsoft Academic Search

OBJECTIVE--To investigate the morphology of congenitally bicuspid aortic valves causing pure valve regurgitation. DESIGN--A case series collected over five years. SETTING--An academic hospital. PATIENTS AND METHODS--One hundred and forty eight excised congenitally bicuspid aortic valves. The morphological findings were correlated with sex, age, clinical history, and data on haemodynamic function before operation. Pure valve regurgitation was defined as grade 3-4\\/4

A S Sadee; A E Becker; H A Verheul; B Bouma; G Hoedemaker



Molecular and clinico-pathological markers in rectal cancer: a tissue micro-array study  

PubMed Central

Aims The aims of the study were to study the effect of pre-operative treatment on the expression of tumour-related proteins and to correlate the expression of these proteins with response and survival of patients with advanced rectal cancer. Materials and methods Tissue micro-arrays from pre- and post-treatment biopsies of 99 patients with rectal cancer treated with pre-operative (chemo)radiotherapy were stained for epidermal growth factor receptor (EGFR), carbonic anhydrase IX, Ki67, vascular endothelial growth factor, cyclo-oxygenase 2 (COX-2) and cleaved cytokeratin 18 (c-CK18). Also, fibro-inflammatory alterations after treatment were evaluated. Results Pre-operative (chemo)radiotherapy caused fibro-inflammatory changes, a downregulation of proliferation (Ki67) and EGFR and an upregulation of apoptosis (cleaved CK18). Patients with a good regression during pre-operative treatment showed less proliferating and apoptotic cells in the resection specimen. Multivariate analysis showed that T downstaging, fibro-inflammatory changes in the resection specimen and COX-2 expression in the biopsy correlated with overall survival. Conclusions Pre-operative treatment has an effect on proliferation, apoptosis, inflammation and EGFR expression. The classical clinical parameters as well as fibro-inflammatory changes and COX-2 expression seem most valuable as predictors for survival. PMID:19050903

Goethals, Laurence; Libbrecht, Louis; Perneel, Christiaan; Geboes, Karel; Ectors, Nadine; McBride, William H.; Haustermans, Karin



Clinico-epidemiological study of Schistosomiasis mansoni in Waja-Timuga, District of Alamata, northern Ethiopia  

PubMed Central

Background Intestinal schistosomiasis, caused by digenetic trematodes of the genus Schistosoma, is the most prevalent water related disease that causes considerable morbidity and mortality. Although prevalence of Schistosoma mansoni infection has been reported for the present study area, earlier studies have not estimated intensity of infections in relation to periportal fibrosis, which would have been crucial for epidemiological and clinical evaluations. Hence, a community based cross sectional study was conducted from December 2011 to March 2012 to assess prevalence of infection and schistosomal periportal fibrosis in Waja-Timuga, northern Ethiopia. Methods In a cross sectional study involving 371 randomly selected individuals, fresh stool samples were collected and processed by the Kato-Katz method and examined microscopically. Ultrasonography was used to determine status of schistosomal periportal fibrosis and to detect hepatomegaly and/or splenomegaly. Serum was collected for assay of hepatic activity. Statistical analysis was performed using STATA 11 statistical soft ware. P-value <0.05 was reported as statistically significant. Results The prevalence of S.mansoni infection was 73.9%, while the prevalence of schistosomal periportal fibrosis was 12.3% and mean intensity of infection was 234 eggs per gram of stool. Peak prevalence and intensity of S.mansoni infection was documented in the age range of 10–20 years. Among the study individuals, hepatomegaly was recorded in 3.7% and splenomegaly was recorded in 7.4% of the study individuals. Similarly, among the study individuals who had definite periportal fibrosis, 5.9% had elevated liver enzyme levels. Conclusion The high prevalence of Schistosoma mansoni infection and schistosomal periportal fibrosis observed in the study area calls for a periodic deworming program to reduce disease, morbidity and transmission. Preventive chemotherapy complemented with other control measures is highly required for sustainable control of schistosomiasis in the study area. PMID:24690404



Clinico-pathologic correlation of liver damage in patients treated with 6-mercaptopurine and Adriamycin.  


Eleven adults with refractory leukemia treated with a combination of 6-mercaptopurine and Adriamycin developed hepatic dysfunction manifested by elevations of serum total bilirubin, alkaline phosphatase, and glutamic oxaloacetic transaminase. Liver tissue obtained at necropsy showed intrahepatic cholestasis (eight cases), hepatocellular necrosis (ten cases), leukemic infiltration (two cases), and fatty change (nine cases). Neither this frequency nor severity of hepatocellular destruction has hitherto been associated with 6-mercaptopurine at the dose levels used in this study, nor has Adriamycin previously been found to be hepatotoxic. It is postulated that Adriamycin potentiated the hepatotoxicity of 6-mercaptopurine in these patients. PMID:1068739

Minow, R A; Stern, M H; Casey, J H; Rodriguez, V; Luna, M A



Peripheral Desmoplastic Ameloblastoma in Adolescent Age: Clinico-Pathological and Immunohistochemical Analisys of a Case  

PubMed Central

The Extraosseous or Peripheral Ameloblastoma (PA) is a rare and benign odontogenic tumour, representing 1% to 5% of all ameloblastomas. It is usually localized in the soft oral tissues, without deep bone involvement. Its biological behaviour is specific, and several authors define PA as a non-infiltrating hamartomatous lesion. Indeed, recurrences rarely occur and progression in malignant tumors appears to be rare. The PA originates from the tooth-forming apparatus and it consists of proliferating odontogenic epithelium, exhibiting the same histological cell types and patterns of the intraosseous counterpart or infiltrating ameloblastoma. The peripheral desmoplastic ameloblastoma (PDA) can be classified as a newly recognized and very rare histological variant. To our knowledge, only a few cases of adult patients affected by PDA have been published. The aim of this paper is to report a case of PDA affecting an adolescent patient. The clinical-pathological and immunohistological features are discussed in order to improve knowledge regarding a correct diagnosis and to differentiate PDA lesions from similar diseases.

Oteri, Giacomo; Lentini, Maria; Pisano, Michele; Cicciu, Marco




PubMed Central

Helicobacter pylori is a spiral Gram-negative bacterium with a relatively small genome and is known to be the most common human bacterial infection worldwide, infecting about half of the world's population. The bacterium represents one of the most successful human pathogens, inducing severe clinical symptoms only in a small subset of individuals, thus signifying a highly balanced degree of co-evolution of H. pylori and humans. The prevalence of Helicobacter pylori infection varies greatly among countries and among population groups within the same country, but is falling in most developed countries. The clinical course of H. pylori infection is highly variable and is influenced by both microbial and host factors including genetic susceptibility while the pattern and distribution of inflammation correlate strongly with the risk of clinical sequelae, namely duodenal or gastric ulcers, mucosal atrophy, gastric carcinoma, or gastric lymphoma. Cytokine gene polymorphisms directly influence inter-individual variation in the magnitude of cytokine response, and this clearly contributes to an individual's ultimate clinical outcome. Polymorphisms in genes coding for innate immune factors have also been incriminated in the pathogenesis of H. pylori related disease, while promoter hypermethylation of tumor suppressor genes is considered an important factor in carcinogenesis and known to be present in H. pylori associated gastric tumors. Functional genomics may fill many of the gaps in our understanding of the pathogenesis of H. pylori infection and accelerate the development of novel therapies, including H. pylori specific antimicrobial agents.

Oluwasola, A.O.



Clinico-pathological correlates of incidentally revealed thyroid swelling in Bihar, India  

PubMed Central

Background: Global prevalence of thyroid cancer has been on the rise in recent decades. Objectives: To study the clinical presentations to reach an agreement for diagnosis and optimal management of incidentally revealed thyroid swellings for early diagnosis. Materials and Methods: A prospective study was carried out on 178 cases of incidentally detected thyroid swelling attending a tertiary care teaching institute of Kishanganj Bihar. All the cases were subjected to a thorough clinical examination followed by evidence-based interventions. Fine needle aspiration cytology was done in all the cases preoperatively as out-patients basis and histopathologically confirmed postoperatively. Results: The highest incidence of thyroid swelling (75.84%) was found in the age group of 20-40 years; a female preponderance was noted in the ratio 4:1. The duration of swelling ranged from six months to three years. Difficulty in swallowing and breathing was complained by 23 (12.9%) and 18 (10.1%) of the patients respectively. Typically the swellings were located in the right lobe. Commonly the subjects in our study were in euthyroid state (90%) and were with firm swellings (66.7%). Follicular and anaplastic carcinoma was important postoperative cytological findings. Majority of surgical intervention was hemithyroidectomy (55.06%). Conclusion: Incidentally revealed thyroid swelling was quite high in eastern India for which we need a consensus line of intervention. PMID:22368398

Sengupta, Arup; Pal, Ranabir; Kar, Sumit; Zaman, Forhad Akhtar; Basu, Mausumi; Pal, Shrayan



[The clinico-laboratory characteristics and diagnosis of acute stomatogenic sepsis].  


Thirty-four patients with acute stomatogenic sepsis developing in grave ulcerative necrotic stomatitis (including that in Stevens-Johnson's and Lyell's syndromes) were examined. Homeostasis parameters were shifted in these patients. To facilitate timely diagnosis of acute stomatogenic sepsis, the authors offer a differential diagnostic table. Patients with grave forms of stomatitis are recommended to be referred for examination and treatment to specialized dentistry hospitals in order to early diagnose the disease and prevent the development of acute sepsis. PMID:8754538

El'kova, N L; Korchinova, L D; Kobtseva, T M



A new report on the occurrence of clinico-histopathological diagnostic criteria for Spinodiplotriaena.  


Parasitic diseases of wild birds follows its companion volume, infectious diseases of wild birds, both of which complement the third edition of infectious diseases of wild mammals and second edition of parasitic diseases of wild mammals. In October 2012, a mature black male mynah with lack of balance and ataxia was brought into the birds department of educational hospital in veterinary medicine faculty of Tehran University. Because of no cure in clinical signs after several days of empirical therapy euthanasia and clinical pathology studies were performed. There was no microscopic pathological lesions in brain, bone marrow, heart, lung, liver and the microscopic results were as following; bone marrow: hemophagocytosis reactive macrophages, liver: infiltration of inflammatory cells (hepatitis) and hemosiderin-laden macrophages. Lung: hemosiderin-laden macrophages and spleen findings: infiltration of inflammatory cells, heterophils with phagocytic bacteria. In abdominal cavity two male and one female parasite was detect. Three parasites were cleared with lactophenol and investigated under the light microscopy and important morphological parts of them measured. Also these parasites in serum containing send to the department of parasitology. Based on all collecting data, Spinodiplotriaena (three parasites each by the length of 2/5, 1/7 and 1/5 cm were found) were diagnosed. Report of this case in important because of first report of this infection in a black mynah in Iran. PMID:25035597

Javanbakht, Javad; Hosseini, Ehsan; Karimi, Shahram; Hassan, Mehdi Aghamohammad; Sabbagh, Atefeh; Mousavi, Shadi; Fattahi, Roohollah; Khaki, Fariba; Shafiee, Radmehr



Universality theorems for con guration spaces of planar Michael Kapovich and John J. Millson  

E-print Network

Universality theorems for con guration spaces of planar linkages Michael Kapovich and John J L0 so that M(L0) is Nash isomorphic to a disjoint union of a nite number of copies of X. Remark 1.1. Nash isomorphism is de ned in x2. Nash isomorphism implies real analytic isomorphism. Similarly we have

Millson, John


Non Invasive Biomedical Analysis - Breath Networking Session at PittCon 2011, Atlanta, Georgia  

EPA Science Inventory

This was the second year that our breath colleagues organized a networking session at the Pittsburgh Conference and Exposition or ''PittCon'' ( time it was called "Non-invasive Biomedical Analysis" to broaden the scope a bit, but the primary focus rema...



Microsoft Academic Search

Resumen El síndrome poliendocrino autoinmune (SPA) es la asociación de enfermedades endocrinas autoinmu- nes con otros desórdenes autoinmunes no endocrinos. Los tipos 1, 2 y 4 presentan adrenalitis autoinmune, esto indica la presencia de autoanticuerpos, y su marcador serológico específico es el anti 21 hidroxilasa (a21-OH). El SPA tipo 2 es la asociación de adrenalitis, enfermedad tiroidea y\\/o diabetes mellitus



phosphorylation at these sites, disrupted effects of glucose on CRTC2 activity in hepatocytes, con-  

E-print Network

phosphorylation at these sites, disrupted effects of glucose on CRTC2 activity in hepatocytes, con expression (G6Pase) in hepatocytes (Fig. 4A and fig. S8). Conversely, RNAi-mediated knockdown of OGT blocked-GlcNAcase (GCA) (12). Expression of adenovirally encoded GCA (Ad-GCA) in hepatocytes reduced amounts of OG-CRTC2

Nizet, Victor


Accordo con Teatridithalia (1) Stagione ELFO PUCCINI 2013/2014. AGEVOLAZIONI E PREZZI RIDOTTI  

E-print Network

Accordo con Teatridithalia (1) Stagione ELFO PUCCINI 2013/2014. AGEVOLAZIONI E PREZZI RIDOTTI PUCCINI 2013/2014, il biglietto per le sale del Teatro Elfo Puccini è ridotto da 30,50 a 21,50; Per la Stagione Elfo Puccini, i giovani fino a 25 anni e gli anziani oltre i 65 anni hanno diritto ad un biglietto

De Cindio, Fiorella


Nitrogen is present in the environment in many forms. The earth's atmosphere con-  

E-print Network

nitrogen compounds that are convert- ed to nitrates in the soil. Nitrates dissolve easily in water and canNitrogen is present in the environment in many forms. The earth's atmosphere con- sists of 70 percent nitrogen. When nitrogen interacts with another element in the environment, it changes form


The Solutions of LCD Panel (T-Con) EMI Noise for Wireless Integration  

Microsoft Academic Search

Electromagnetic interference (EMI) from a LCD panel deteriorates the performance of wireless network system (including Wireless network cards: Wireless Local Area Network (WLAN) card and Wireless Wide Area Network (WWAN) card) in a notebook. One of the main EMI noise source for the wireless network system in a liquid crystal display (LCD) panel is the timing controller IC (T-Con). In

Sung-Kyu Lee; Jung-man Lim; Ki-Seob Lee; On-Sik Choi; Bae-Won Lee; Do-Wan Kim; Masashi Hayakawa; Yoshio Kami




Microsoft Academic Search

En la Comunidad costera de Cascarero del Municipio Jesús Menéndez, se detectó que existen condiciones desfavorables para lograr la equidad de género, influyendo diversos factores. De ahí que se investigó el proceso para favorecer la equidad de género con el propósito de resolver la insuficiente incorporación de la mujer en actividades económicas, políticas y sociales, por ello el trabajo de

Aiblis Susel Vidal Marrero; Yasenny Bravo Sánchez




Microsoft Academic Search

Determinar la relación que existe entre hábitos de estudio, actitudes y autoestima con el rendimiento académico de los estudiantes de la Facultad de Enfermería de la Universidad Veracruzana. METODOLOGÍA: Diseño de investigación descriptivo, correlacional. La población estuvo constituida por 377 estudiantes inscritos durante el periodo Febrero – Julio, 2010. El tipo de muestreo fue probabilístico estratificado; la muestra fue de

Fabiola Cruz Núñez




Microsoft Academic Search

RESUMEN El uso de dispositivos intrauterinos con levonorgestrel (DIU-LNG) además de su efecto anticoncepti- vo, disminuye significativamente el sangrado uterino. Esto hace que los DIU-LNG expresen beneficios tales como el control del sangrado uterino, especialmente en metrorragias o menometrorragias por enfermedades orgánicas como miomatosis uterina. Sin embargo, en nuestro medio existen dudas sobre los beneficios reales de estos métodos y



Percentile bootstrap con...dence intervals Suppose that a quantity = (F) is of interest and that  

E-print Network

Percentile bootstrap con...dence intervals Suppose that a quantity = (F) is of interest and that Tn = (the empirical distribution of Y1; Y2; : : : ; Yn) Based on B bootstrapped values Tn1; Tn2; : : : ; Tn points for the histogram/empirical distribution of the B bootstrapped values). For kL = j 2 (B + 1) k

Vardeman, Stephen B.


The Con Edison Emergency Child Care Plan for Management Employees: Summary Plan Description.  

ERIC Educational Resources Information Center

This summary plan description offers guidelines for participation in a pilot program that provides short-term emergency care for children of Con Edison managers who are under 13 years old. The plan offers professional, in-home child care that can be used when usual arrangements have collapsed. The summary plan description addresses the following…

Consolidated Edison Co., Brooklyn, NY.


Una entrevista con Inés Margarita Stranger (Chile) y sus personajes femeninos  

E-print Network

FALL 1996 89 Una entrevista con Inés Margarita Stranger (Chile) y sus personajes femeninos Pedro Bravo-Elizondo A la fecha, su vida contempla un título como teatrista por la Universidad Católica de Chile en la cual es profesora en la Escuela de...

Bravo-Elizondo, Pedro



Investigating Mould Heat Transfer in Thin Slab Casting with CON1D Begoa Santillana  

E-print Network

in continuous casting is important to mould life, surface quality, breakouts and many aspects of the process-slab casting, numerical modelling, funnel mould, continuous casting of steel INTRODUCTION Mould heat transfer MODEL DESCRIPTION The heat transfer model, CON1D1 , models several aspects of the continuous casting

Thomas, Brian G.


owi'3:%l OORNL/CON-75 Effect of Forced Ventilation on  

E-print Network

in furnaces, water heaters, and fireplaces. * W. P. Levins, Energy and the Laundry Process, ORNL/CON-14 (April. Calculations were made for 17 cities across the United States showing the effect of dryer location on house energy consumption. SUMMARY An experiment was conducted at the Tennessee Energy Conservation in Housing

Oak Ridge National Laboratory


Introduccion a la demostracion asistida por ordenador (con Isabelle/Isar)  

E-print Network

Introducci´on a la demostraci´on asistida por ordenador (con Isabelle/Isar) Jos´e A. Alonso Jim recursi´on primitiva . . . . . . . . . . . . . . . . . . . . . . 14 2 El lenguaje de demostraci´on Isar 15 2.1 Panorama de la sintaxis (simplificada) de Isar . . . . . . . . . . . . . . . . . 15 2

Alonso, José A.


Iron formations are typically thinly bed-ded or laminated sedimentary rocks con-  

E-print Network

222 ABSTRACT Iron formations are typically thinly bed- ded or laminated sedimentary rocks con- taining 15% or more of iron and a large pro- portion of silica (commonly >40%). In the ca. 2590­2460 Ma Campbellrand-Kuruman Complex, Transvaal Supergroup, South Africa, iron formation occurs as a sediment- starved

Fischer, Woodward



Microsoft Academic Search

Sommario Il riciclo meccanico dei materiali compositi a matrice termoplastica rinforzati con fibre corte di vetro permette di recuperare sia materiale dismesso a fine vita sia gli scarti industriali di lavorazione. Esso consiste nella macinazione e successivo impiego del materiale macinato nel processo di stampaggio a iniezione. In questa memoria viene presentato lo studio del comportamento a fatica di una

A. Bernasconi; P. Davoli; D. Rossin


Heat-Transfer and Solidification Model of Continuous Slab Casting: CON1D  

E-print Network

Heat-Transfer and Solidification Model of Continuous Slab Casting: CON1D YA MENG and BRIAN G. THOMAS A simple, but comprehensive model of heat transfer and solidification of the continuous casting of steel slabs is described, including phenomena in the mold and spray regions. The model includes a one

Thomas, Brian G.


Copyright 2008 Psychonomic Society, Inc. 116 Categorization performances by pigeons can be con-  

E-print Network

Copyright 2008 Psychonomic Society, Inc. 116 Categorization performances by pigeons can be con rela- tions among stimuli become problematic (Herrnstein, Loveland, & Cable, 1976). Pigeons learn to describe experimental results from both hu- mans and pigeons (Herrnstein et al., 1976; Rosch, 1978

Herbranson, Wally



E-print Network



While the current trend towards lightweight con-structions may be of both economical and envi-  

E-print Network

- gate the transmission of diffuse incident sound waves through typical simple lightweight con of the level of sound and vibration is an important is- sue that must be dealt with by optimizing the designs below 2 kHz and the load acts as an approximated diffuse field on one side of the panel. Subject

Hansen, René Rydhof


Red GPS a Tiempo Real con Precisiones Centrimtricas para Utilizar en los Sistemas de  

E-print Network

Red GPS a Tiempo Real con Precisiones Centrim�tricas para Utilizar en los Sistemas de Informaci�n Desarrollo Tecnol�gico Instrumentaci�n � Distanci�metros � Total Stations + C�mara +GPS � Laser Scanners � GPS � GPS Reference Stations � GPS Internet Ready � PDA � Tecnolog�a Bluetooth Mapa de Puerto Rico

Gilbes, Fernando


Although most Minnesota airports do not have much concrete pavement, the con-  

E-print Network

Although most Minnesota airports do not have much concrete pavement, the con- crete they do have are generally constructed out of concrete that is much thicker. Maintaining any section of pavement, regardless of its size, is important for pre- serving its condition and optimizing pave- ment life. Pavement

Minnesota, University of


Un director chileno en el Berliner Ensemble (Entrevista con Alejandro Quintana Contreras)  

E-print Network

hora." INTEGRACIÓN CHILENO-ALEMANA. Después montaron el programa músico- teatral Con el alma llena de banderas, sobre la vida y momentos en que Víctor Jara compone y escribe sus canciones. Fue una experiencia interesante pues fue el primer intento de...

Bravo-Elizondo, Pedro



Sexual con ict and cooperation in butter y reproduction: a comparative study of polyandry  

E-print Network

Sexual con ict and cooperation in butter y reproduction: a comparative study of polyandry University, S-10691 Stockholm, Sweden Most butter£y species can be characterized as capital breeders, meaning for the evolution of nuptial gifts in butter£ies are discussed, one arguing that variation in larval food

Leimar, Olof


Project Plan Field Assessment of the Effectiveness of DiazaConTM on Reducing Gray  

E-print Network

). This project proposes to field test DiazaConTM in reducing EGS reproduction and damage on the entire campus Reproduction and Population January 2011 ­ May 2014 Dr. Greg Yarrow, Professor of Wildlife Ecology Kristina reproduction in a small group (317) of EGS on the campus of Clemson University demonstrated

Bolding, M. Chad


recruited from other Pediatric Oncology Group (POG) institutions before treatment began. Informed con-  

E-print Network

con- sent was obtained, and procedures approved by the Committee on Human Research at the University cell fraction was obtained for the T cell cloning assay within 12 to 24 hours of its collection. The T cell cloning assay and analysis have been described [see B. A. Finette et al., Mutat. Res. 308, 223

Eddy, Sean


Elizabeth A.Johnson y Kefyn M.Catley con ilustraciones de Patricia J. Wynne  

E-print Network

a Nivel de la Hojarasca...............................5 Algunos de los Animales de la Hojarasca que ............................................7 Osos de Agua .......................................................9 Animales con Patas A R A S C A 1 Introducción Cuando pensamos en animales urbanos, es posible que nos vengan a la mente


expected thermal conductivity, assuming a con-stant G 260 MW m 2  

E-print Network

required of ther- mal barrier coatings. Applications of nanolami- nates as thermal barriers at temperaturesexpected thermal conductivity, assuming a con- stant G 260 MW m 2 K 1 and fixed values for the thermal conductivities of the individual alumina and W layers. For the ALD nanolami- nate with 1/ 0.35 nm

Torquato, Salvatore


Integrated Concentration in Science, 2012 High Fructose Corn Syrup a mini iCons case study  

E-print Network

� Integrated Concentration in Science, 2012 High Fructose Corn Syrup� a mini iCons case study researchers find that high fructose corn syrup prompts considerably more weight gain. The Atlantic, Aug 13, 2012 � Study: High fructose corn syrup no worse than `real' sugar

Auerbach, Scott M.


Are You Ready to Go Digital?: The Pros and Cons of Electronic Portfolio Development  

ERIC Educational Resources Information Center

There is an increasing need for educators to have professional portfolios, which are considered to be authentic tools for evaluating the knowledge, skill, beliefs and attitudes of prospective educators. Electronic portfolios are gaining in popularity and their relative pros and cons are examined.

Heath, Marilyn



One-dimensional simulation of co-current, dairy spray drying systems pros and cons  

E-print Network

Review One-dimensional simulation of co-current, dairy spray drying systems ­ pros and cons Kamlesh PATEL 1 , Xiao Dong CHEN 1*, Romain JEANTET 2,3 , Pierre SCHUCK 2,3 1 Biotechnology and Food Engineering parameters and product properties before conducting real spray drying trials. The main advantage of a 1-D

Boyer, Edmond


DESign AnD conStruction College of Engineering and Mines  

E-print Network

in the construction industry. The program was designed in collaboration with construction industry em- ployers and continues to engage industry as a partner in the program. Engineers and other construction professionalsDESign AnD conStruction MAnAgEMEnt College of Engineering and Mines Department of Civil

Hartman, Chris


Enhanced ballistic performance of conned multi-layered ceramic targets against long rod penetrators through  

E-print Network

Enhanced ballistic performance of con®ned multi-layered ceramic targets against long rod Science Ltd. All rights reserved. Keywords: Ballistic penetration; Damage; Fragmentation; Interferometry is one of the most important material properties that in¯uence its ballistic performance and motivated

Espinosa, Horacio D.


Adsornftl 8~f^Ll* ORNL/CON-155 O173IS1o COp  

E-print Network

of Stirling Engine Thermodynamics N. C. J. Chen F. P. Griffin C. D. West OPERATED BY TAHP *MARTIN MARIETTA Government or any agency thereof. #12;ORNL/CON-155 LINEAR HARMONIC ANALYSIS OF STIRLING ENGINE THERMODYNAMICS ................... 8 2.3 Integrated Energy Equations ......................... 11 2.4 Engine Performance Parameters

Oak Ridge National Laboratory


ConSOM: A conceptional self-organizing map model for text clustering  

Microsoft Academic Search

In the novel conceptional self-organizing map model (ConSOM) proposed for text clustering in this paper, neurons and documents can be represented by two vectors: one in extended concept space, and the other in traditional feature space, and weight modification of neuron vector is guided by combination of similarities in both traditional and extended spaces. Experimental results show that by utilizing

Yuanchao Liu; Xiaolong Wang; Chong Wu



22 Wisconsin Natural Resources These are all good ways to con-  

E-print Network

. This reduces water needs in those areas of the gardens and re- duces water "lost" to storm sewers. Creating22 Wisconsin Natural Resources These are all good ways to con- serve water but are only part of your water conservation opportu- nity. These practices focus on water demand as it relates to drawing

Saldin, Dilano


Diseño de Metaheurísticos para Problemas de Rutas con Flota Heterogénea: Concentración Heurística  

Microsoft Academic Search

En este trabajo se propone un algoritmo Metaheurístico para el problema de rutas con ventanas de tiempo, carga y descarga simultánea y flota heterogénea, basado en un proceso de tipo Concentración Heurística, un tipo de Metaheurístico dado a conocer muy recientemente por Rosing (1997) y Rosing y ReVelle (1997), compuesto en dos fases: en la primera se obtienen un conjunto




which settles the debate about the exclusiveness of memory con-solidation during sleep.  

E-print Network

an effect of REM sleep deprivation on the improvement in the visual discrimination task but not for slow wave sleep deprivation, whereas Stickgold et al. (2000b) reported correlations for slow wave sleepwhich settles the debate about the exclusiveness of memory con- solidation during sleep


DIGITAL.CSIC: "Catalogacin con Dublin Core, gestin de derechos de  

E-print Network

DIGITAL.CSIC: "Catalogación con Dublin Core, gestión de derechos de autor y permisos de editores;Copyright y el acceso abierto #12;¿De qué estamos hablando? · Derechos de autor: conjunto de normas y principios que regulan los derechos morales y patrimoniales que la ley concede a los autores por el solo


TITLE: Shifting Agrarian Landscapes: Climate Change and Adaptation in Bangladesh HOSTS: Jason Cons and Shelley Feldman  

E-print Network

TITLE: Shifting Agrarian Landscapes: Climate Change and Adaptation in Bangladesh HOSTS: Jason Cons fragile lowland areas of the Ganges Delta, in which the vast majority of Bangladesh is situated. For rural and water resources are rapidly reorganizing village-life and changing Bangladesh's agrarian landscapes. Far

Angenent, Lars T.


Safety and Toxicity Evaluation of GonaCon ™ Immunocontraceptive Vaccine in White-Tailed Deer  

Microsoft Academic Search

GonaCon ™ Immunocontraceptive Vaccine targets the reproductive hormone gonadotropin releasing hormone (GnRH) secreted by the hypothalamus of the brain. Antibodies produced in response to the vaccine inactivate endogenous GnRH, which in turn eliminates stimulation of the pituitary gland and gonads in males or females. The resulting \\

Gary Killian; Donald Wagner; Richard Engeman; Lowell Miller


HumanWildlife Conflicts 3(1):7287, Spring 2009 Historical review of elkagriculture con-  

E-print Network

population. Conflicts between farmers and government about elk management often have been characterized the impacts of elk. Future programs to address these conflicts should focus on collaboration and communicationHuman­Wildlife Conflicts 3(1):72­87, Spring 2009 Historical review of elk­agriculture con- flicts



Microsoft Academic Search

In this paper we are discussing Thermodynamics properties associated to black holes based on thermodynamics characteristics owns of a physics system with Negative Thermal Capacity, and we show a model that relates temperature and mass in a Schwarzschilds black hole INTRODUCCIÓN Los Agujeros Negros son objetos cosmológicos singulares, con una fuerte interacción gravitacional. Nada, incluyendo la luz, puede escapar de

Agujero Negro


Un estudio financiado por los Institutos Nacionales de la Salud (NIH) muestra reducción en la mortalidad entre hombres con cáncer de próstata en grado intermedio:

Terapia hormonal por corto tiempo administrada en combinación con radioterapia a hombres con cáncer de próstata en estadio inicial aumentó sus posibilidades de vivir más en comparación con tratamiento de radioterapia sola, según un estudio clínico patrocinado por el NCI. Los beneficios del tratamiento combinado se limitaron principalmente a pacientes con enfermedad de riesgo intermedio y no se observaron en hombres con cáncer de próstata de riesgo bajo, indican los investigadores.


Añadir quimioterapia después de la radioterapia mejora la supervivencia de adultos con un tipo de tumor cerebral de crecimiento lento

Adultos con gliomas de grado bajo, una forma de tumor cerebral, que recibieron tratamiento con quimioterapia después de la radioterapia vivieron más tiempo que pacientes que recibieron solo radioterapia, según los resultados de seguimiento a largo plazo de un estudio clínico aleatorizado y controlado, subvencionado por los NIH.


0^T^^^tf^*nl~~~~ ORNL/CON-154 Nonlinear Analysis of Stirling  

E-print Network


Oak Ridge National Laboratory


Summary Rising atmospheric carbon dioxide (CO2) con-centration ([CO2]) could alter terrestrial carbon (C) cycling by  

E-print Network

Summary Rising atmospheric carbon dioxide (CO2) con- centration ([CO2]) could alter terrestrial increase in tropospheric ozone (O3) con- centration ([O3]) will interact with rising atmospheric [CO2 of CBSCs were rarely signifi- cantly affected by the CO2 and O3 treatments in decomposing fine roots. Rates



E-print Network

14th World Congress of IFACA FINITE-DIMENSIONAL CODER-ESTIMATOR FOR RATE-CONS... Copyright © 1999 VIC 3052 Australia email:, EXTENDED ABSTRACT This paper;14th World Congress of IFACA FINITE-DIMENSIONAL CODER-ESTIMATOR FOR RATE-CONS... ISBN: 0 08 043248 4

Nair, Girish


ConBr, a lectin from Canavalia brasiliensis seeds, protects against quinolinic acid-induced seizures in mice.  


Lectins are proteins capable of reversible binding to carbohydrates or glycoconjugates. In the central nervous system of mammals, lectins with affinity for mannose/glucose or galactose can modulate cellular communication. ConBr, a lectin isolated from the seeds of Canavalia brasiliensis, previously showed antidepressant effect in the forced swimming test in mice, with involvement of the monoaminergic system. In this study, we investigated the neuroprotective effects of ConBr against quinolinic acid (QA), a well-known NMDA agonist that produces severe neurotoxicity when administered in vivo. ConBr (10 ?g/site) administered via intracerebroventricular (i.c.v.) showed a neuroprotective activity against seizures induced by QA (36.8 nmol/site; i.c.v.) when administered 15 min prior to QA, with a percentage of protection around 50%. ConBr was also able to significantly decrease the severity of the seizures but without changes in the latency of the first convulsion or the duration of the seizures. This effect was dependent on the structural integrity of the ConBr protein and its binding capacity to oligosaccharides residues. ConA, a lectin with high similarity to ConBr, did not reverse the QA-induced seizures. Moreover, ConBr was able to protect against hippocampal cell death caused by QA, which was measured by propidium iodide incorporation. QA caused activation of JNK2 and improved the phosphorylation of Ser831 and 845 on the AMPA receptor GluR1 subunit, and both of these effects were counteracted by ConBr. Our data suggest that the lectin ConBr may exert a modulatory action on NMDA receptors, which inhibits its activity in response to QA. PMID:21948344

Russi, Michael A; Vandresen-Filho, Samuel; Rieger, Débora K; Costa, Ana Paula; Lopes, Mark W; Cunha, Rodrigo M S; Teixeira, Edson H; Nascimento, Kyria S; Cavada, Benildo S; Tasca, Carla I; Leal, Rodrigo B



Air Traffic Management Technology Demonstration-1 Concept of Operations (ATD-1 ConOps)  

NASA Technical Reports Server (NTRS)

The operational goal of the ATD-1 ConOps is to enable aircraft, using their onboard FMS capabilities, to fly Optimized Profile Descents (OPDs) from cruise to the runway threshold at a high-density airport, at a high throughput rate, using primarily speed control to maintain in-trail separation and the arrival schedule. The three technologies in the ATD-1 ConOps achieve this by calculating a precise arrival schedule, using controller decision support tools to provide terminal controllers with speeds for aircraft to fly to meet times at a particular meter points, and onboard software providing flight crews with speeds for the aircraft to fly to achieve a particular spacing behind preceding aircraft.

Baxley, Brian T.; Johnson, William C.; Swenson, Harry; Robinson, John E.; Prevot, Thomas; Callantine, Todd; Scardina, John; Greene, Michael



Numerical method for accelerated calculation of cyclic steady state of ModiCon-SMB-processes  

Microsoft Academic Search

The classical SMB-process including its ModiCon-variant is considered. The mathematical model corresponds to a set of coupled nonlinear partial differential equations completed by initial and boundary conditions. In order to predict the quality of the separation process accurately and efficiently discretization schemes are needed. We propose a new cascadic multilevel method for the fast calculation of the cyclic steady state

R. Lübke; Andreas Seidel-morgenstern; L. Tobiska



NASA KSC/AFRL Reusable Booster System (RBS) Concept of Operations (ConOps)  

NASA Technical Reports Server (NTRS)

This slide presentation reviews the study and findings of the study on the Concept of Operations (ConOps) for Reusable Booster System (RBS) centering on rapid turnaround and launch of a two-stage partially reusable payload delivery system (i.e., 8 hours between launches). The study was to develop rapid ground processing (aircraft like concepts) and identify areas for follow-on study, technology needs, and proof-of-concept demonstrations.

Zeno, Dnany; Mosteller, Ted; McCleskey, Carey; Jhnson, Robert; Hopkins, Jason; Miller, Thomas



Anticipated Stigma and Stigma Management Among Those to be Labeled “Ex-con”  

Microsoft Academic Search

Male prisoners (n = 450) estimated public reaction to the label “ex-con” and endorsed likely stigma management strategies. Although most anticipate significant rejection, they prefer preventative telling to withdrawal and secrecy as adjustments. OLS regression finds factors promoting exclusion (devaluation\\/discrimination beliefs and reduced job opportunities) related to withdrawal and secrecy, whereas factors favoring inclusion (“wise” family and friends and plans to attend

Terri A. Winnick; Mark Bodkin



Matemtica para ubicarse En cualquier lugar del planeta y ms all con el GPS  

E-print Network

Matemática para ubicarse En cualquier lugar del planeta y más allá con el GPS matbaires 09 Pablo Groisman Dpto. de Matemática FCEN-UBA CONICET #12; ¿Qué es GPS? #12; Aplicaciones #12 corrección de errores para los GPS. Reloj atómico que marca la hora oficial de EEUU. (In) presición: 1

Groisman, Pablo


Foglio di esercizi N. 3 1. Con il linguaggio degli "o-piccolo": per x 0  

E-print Network

Foglio di esercizi N. 3 1. Con il linguaggio degli "o-piccolo": per x 0 2x = 1 + x log 2 + o(x), 3x = 1 + x log 3 + o(x), quindi 2x - 3x = (log 2 - log 3)x + o(x). Dato che -1 sin 1 x 1, si ha -x x sin 1 x x, e quindi (per il teorema dei due carabinieri) lim x0+ x sin 1 x = 0, ovvero x sin 1 x

Tauraso, Roberto


Range Con: a management evaluation system for assessing sucess of selected range improvement practices  

E-print Network

and content by: . N. Stu Cha of Committee) J. R. Conner (Member) . T. Hamilton (Member) J. L. Schuster (Head of Department) August 1989 ABSTRACT Range Con: A Management Evaluation System for Assessing Success of Selected Range Improvement Practices.... (August 19B9) Steven Linn Ekblad, B. S. Texas A&M University Chair of Advisory Committee: Dr. J. W. Stuth Decision support systems are currently being used in range management to assist ranch managers and agricultural agency personnel in making...

Ekblad, Steven Linn



Verisimilitude (or “truthlikeness”) as an alternative to pro and cons: migraine and cluster headache mechanisms  

Microsoft Academic Search

Calculating verisimilitude (or “truthlikeness”) ad modum Popper is a quantitative alternative to the usual pros and cons in\\u000a migraine and cluster headache mechanisms. The following items were evaluated: dilation of large cranial arteries during migraine;\\u000a CGRP increase during migraine; migraine as a brain disorder; aura and migraine headache; brain stem activation during migraine;\\u000a rCBF in migraine without aura; NO and

Peer Carsten Tfelt-Hansen



Tratamiento pasivo de aguas cidas de mina con caliza y MgO  

E-print Network

Tratamiento pasivo de aguas ácidas de mina con caliza y MgO: Resultados de los ensayos de campo en de lodos piríticos 200m Pozo de desagüe #12;Lugar de estudio (III): Calidad del agua de mina · pH: 2 debajo de la balsa de lodos Toma de agua Decantador de salida del bidón B Decantador de salida del bidón

Politècnica de Catalunya, Universitat


Structure, stratigraphy and petroleum geology of the south east Nam Con Son Basin, offshore Vietnam  

SciTech Connect

Recent exploration of the south east Nam Con Son Basin, offshore Vietnam, by BP in alliance with Statoil has involved acquisition of new seismic and well data. These new data have allowed re-evaluation of the tectono-stratigraphic development and petroleum geology, and have provided additional constraints on the regional tectonic evolution. The offshore Vietnamese basins have evolved in response to the complex relative motions of Indochina, Peninsular Malaysia, Borneo and the South China Sea during the Cenozoic. On the regional scale these motions have been accommodated by strike-slip fault development, rifting and contraction. In the Nam Con Son Basin these motions have interacted in different ways from the Palaeogene to recent. Two rifting episodes are recognized; a Palaeogene phase dominated by E-W trending extensional faults, and a Miocene phase dominated by N-S to NE-SW trending faults. The structural evolution is complicated by a pulse of mild contraction during the Middle Miocene. The sedimentary fill of the basin evolves from continental fluvio-lacustrine in the Palaeogene through to fully marine following the second phase of rifting in the Miocene. This pulsed structural and stratigraphic evolution has resulted in basinwide deposition of source, reservoir and seal facies, and produced a variety of potential trapping styles. This paper describes the hydrocarbon habitat of the south east Nam Con Son Basin within the context of the regional tectono-stratigraphic model.

Fraser, A.J.; Matthews, S.J.; Lowe, S.; Todd, S.P.; Simon, P. Peel, F.J. (BP Exploration Operating Co., Ltd., Uxbridge (United Kingdom))



Structure, stratigraphy and petroleum geology of the south east Nam Con Son Basin, offshore Vietnam  

SciTech Connect

Recent exploration of the south east Nam Con Son Basin, offshore Vietnam, by BP in alliance with Statoil has involved acquisition of new seismic and well data. These new data have allowed re-evaluation of the tectono-stratigraphic development and petroleum geology, and have provided additional constraints on the regional tectonic evolution. The offshore Vietnamese basins have evolved in response to the complex relative motions of Indochina, Peninsular Malaysia, Borneo and the South China Sea during the Cenozoic. On the regional scale these motions have been accommodated by strike-slip fault development, rifting and contraction. In the Nam Con Son Basin these motions have interacted in different ways from the Palaeogene to recent. Two rifting episodes are recognized; a Palaeogene phase dominated by E-W trending extensional faults, and a Miocene phase dominated by N-S to NE-SW trending faults. The structural evolution is complicated by a pulse of mild contraction during the Middle Miocene. The sedimentary fill of the basin evolves from continental fluvio-lacustrine in the Palaeogene through to fully marine following the second phase of rifting in the Miocene. This pulsed structural and stratigraphic evolution has resulted in basinwide deposition of source, reservoir and seal facies, and produced a variety of potential trapping styles. This paper describes the hydrocarbon habitat of the south east Nam Con Son Basin within the context of the regional tectono-stratigraphic model.

Fraser, A.J.; Matthews, S.J.; Lowe, S.; Todd, S.P.; Simon, P. Peel, F.J. [BP Exploration Operating Co., Ltd., Uxbridge (United Kingdom)



Choice of Ada programming language for the Conflict Model (ConMod)  

SciTech Connect

The Ada programming language was chosen for the Conflict Model (ConMod). ConMod is under development in the Conflict Simulation Center as a high-resolution, large-scale, automated, echelon-above-corps conflict simulation. The project has joint LLNL and Army sponsorship and Air Force participation. To make the language decision, the Kepner-Tregoe decision analysis method was employed. Sets of mandatory (MUST) objectives and desirable (WANT) objectives were established by the project team. Language features that support modern software engineering practices were a primary concern, along with benefits to the eventual ConMod user and aids in program implementation. The initial target machine for the model is the VAX 8800 running the VMS operating system. Six languages were considered. In the order in which they ranked against the WANTS, they were: DEC Ada, DEC Pascal, Logitech Modula-2, DEC FORTRAN, DEC C, and CACI Simscript II.5. Potential adverse consequences of the selection were also considered for the first three. No inhibitory problems were found for the first choice, DEC Ada, and consequently it was adopted. 13 refs.

Tannahill, J.R.; Simonson, S.C.



ConTrack: Finding the most likely pathways between brain regions using diffusion tractography  

PubMed Central

Magnetic resonance diffusion-weighted imaging coupled with fiber tractography (DFT) is the only non-invasive method for measuring white matter pathways in the living human brain. DFT is often used to discover new pathways. But there are also many applications, particularly in visual neuroscience, in which we are confident that two brain regions are connected, and we wish to find the most likely pathway forming the connection. In several cases, current DFT algorithms fail to find these candidate pathways. To overcome this limitation, we have developed a probabilistic DFT algorithm (ConTrack) that identifies the most likely pathways between two regions. We introduce the algorithm in three parts: a sampler to generate a large set of potential pathways, a scoring algorithm that measures the likelihood of a pathway, and an inferential step to identify the most likely pathways connecting two regions. In a series of experiments using human data, we show that ConTrack estimates known pathways at positions that are consistent with those found using a high quality deterministic algorithm. Further we show that separating sampling and scoring enables ConTrack to identify valid pathways, known to exist, that are missed by other deterministic and probabilistic DFT algorithms. PMID:18831651

Sherbondy, Anthony J.; Dougherty, Robert F.; Ben-Shachar, Michal; Napel, Sandy; Wandell, Brian A.




PubMed Central

En la investigación con animales existen cuestionamientos éticos tanto en el uso como modelos de enfermedades humanas y requisito previo para ensayos en humanos como en la introducción de modificaciones genéticas. Algunos de estos cuestionamientos son: no representar exactamente la condición humana como modelos, realizar pruebas de toxicidad con grave daño para los animales, alterar su naturaleza mediante modificaciones genéticas, riesgos de la introducción de organismos genéticamente modificados. El uso de animales en investigación para beneficio humano, impone al ser humano la responsabilidad moral de respetarlo, no haciéndoles sufrir innecesariamente, al estar trabajando con seres vivientes y sentientes. PMID:23338641

Yunta, Eduardo Rodriguez



The Credibility Revolution in Empirical Economics: How Better Research Design is Taking the Con out of Econometrics  

E-print Network

Just over a quarter century ago, Edward Leamer (1983) reflected on the state of empirical work in economics. He urged empirical researchers to “take the con out of econometrics” and memorably observed (p. 37): “Hardly ...

Angrist, Joshua



32 Wesley C. Salmon -it has been appropriate to deny that such appeals to functions involve the con-  

E-print Network

32 Wesley C. Salmon -it has been appropriate to deny that such appeals to functions involve the con's (1962) defense of deductive explanation in her contribution to the third volume #12;34 Wesley C. Salmon

Fitelson, Branden


Los NIH anuncian el lanzamiento de 3 estudios integrados de medicina de precisión; ALCHEMIST es para pacientes con ciertos tipos de cáncer de pulmón en estadio inicial

Los Estudios sobre la Secuenciación e Identificación de Marcadores para el Mejoramiento de la Terapia Adjuvante para el Cáncer de Pulmón, conocidos con el nombre de ALCHEMIST, identificarán a pacientes con cáncer de pulmón en estadio inicial cuyos tumores albergan ciertos cambios genéticos, y evaluarán si los tratamientos con medicamentos que actúan sobre esos cambios pueden mejorar la supervivencia.


The pros and cons of risk communication: A project manager`s guide  

SciTech Connect

Communicating risk is in itself a risky, yet essential, part of any successful hazardous waste project`s community relations strategy. Essential, because no project requiring public involvement can achieve success without effective communication of technical data and associated risks. Risky, because the stakes are high, the public and media are often contentious, and their science and engineering are difficult to relate to non-technical audiences. Given that communicating project risks cannot be avoided, or are avoided at one`s own peril, project managers lacking mastery of communication skills can build winning strategies by heeding the following ``pros`` and ``cons`` of risk communication.

Perry, S.D. [Blasland, Bouck and Lee, Inc., Syracuse, NY (United States)



[Severe acute asthma: isoflurane administration via AnaConDa™, is it safe?].  


Standard treatments against severe acute asthma can be insufficient and need salvation treatments, such as isoflurane delivery. These treatments have not been much assessed and could lead to unrecognized side-effects. We report the case of a young man who suffered from intracranial hypertension associated with severe hypercapnia during the delivery of isoflurane via the system AnaConDa™ or Anaesthetic Conserving Device™ (ACD) (Sedama Medical). The rising of PaCO(2) appears to be linked to an ACD-dependent increase in the dead space. PMID:21146349

Chaillan, M; Badin, J; Kerforne, T; Voultoury, J; Pinsard, M



Esercizi quarta settimana1 Determinare lo sviluppo asintotico delle seguenti funzioni nella scala delle potenze per x 0 con  

E-print Network

delle potenze per x 0 con almeno tre termini consecutivi: ex - sin x - 1 sinh2 x (1 - cosh x) sin x 3 x + x4 cos sin x sin(1 - cos x) esin x cos x + sin x ex2 Determinare lo sviluppo asintotico delle seguenti funzioni nella scala delle potenze per x + con almeno tre termini consecutivi: 3 x + x4 sinh sin

Marconi, Umberto


Extenso estudio realizado en muchos centros demuestra que hay una precisión comparable de la colonoscopia virtual con la colonoscopia convencional

Según los resultados del Estudio Nacional de Colografía de Tomografía Computarizada de la American College of Radiology Imaging Network, ACRIN, la colografía de tomografía computarizada, también conocida como colonoscopia virtual, es comparable a la colonoscopia convencional en su capacidad para detectar con precisión cáncer y pólipos precancerosos y podría servir como examen selectivo inicial de detección de cáncer colorrectal. La colonoscopia convencional usa un tubo largo, flexible, con cámara, para ver el revestimiento del colon.


Uso de Sustancias en Mujeres con Desventaja Social: Riesgo para el Contagio de VIH/SIDA  

PubMed Central

Antecedentes La caracterización epidemiológica en Chile apunta a feminización, pauperización y heterosexualización de la epidemia del VIH, lo que implica un mayor riesgo para las mujeres en desventaja social. Si a esto se suma la utilización de sustancias, la vulnerabilidad de este grupo frente al VIH/SIDA aumenta. Objetivo Describir el uso de sustancias en mujeres con desventaja social e identificar factores de riesgo de contagio de VIH, asociados a este consumo. Material y Método 52 mujeres fueron entrevistadas como parte del proyecto “Testeando una intervención en prevención de VIH/SIDA en mujeres chilenas” GRANT # RO1 TW 006977. Se describen variables sociodemográficas y de consumo de sustancias a través de estadísticas descriptivas y se analiza la relación entre variables a través de pruebas de correlación. Resultados Los resultados indican un perfil sociodemográfico que sitúa a las mujeres en situación de vulnerabilidad frente al contagio de VIH/SIDA, con alto índice de uso de sustancias que acentúa el riesgo. Conclusiones Los hallazgos apuntan a la necesidad de considerar intervenciones que se enfoquen en la prevención de VIH en mujeres, abordando los riesgos asociados al consumo de sustancias. PMID:21197380

Cianelli, R.; Ferrer, L; Bernales, M.; Miner, S.; Irarrazabal, L.; Molina, Y.



Actitudes ?ticas de los estudiantes y egresados en carrera de medicina con metodolog?as activas  

PubMed Central

El presente estudio tiene por objeto desarrollar un diagnostico de la inserción integrada de la ética en la carrera de medicina brasileña con una metodología de aprendizaje basada en problemas y describir las percepciones de actitudes éticas de los estudiantes y egresados. El diseño metodológico es un estudio de caso, descriptivo y documental, con abordaje cualitativo y cuantitativo. La muestra de esta investigación ha sido constituida por 120 estudiantes y 40 egresados de dos promociones del Curso de Medicina de la ESCS. Este proyecto fue aprobado por el Comité de Ética en Investigación - SES/DF. Los estudiantes y egresados de la ESCS demostraron un buen manejo en el abordaje de los conflictos éticos y respeto a los pacientes. Sin embargo, el análisis de sensibilidad ética mostró una fragilidad en las percepciones y aptitudes inapropiadas de los estudiantes de la carrera de medicina, identificada básicamente en los años iniciales, que necesitan más discusiones sistematizadas sobre los aspectos éticos y bioéticos integrados a las actividades prácticas para estimular y fortalecer la reflexión ética de los estudiantes. PMID:20981242

Novaes, Maria Rita Carvalho Garbi; Novaes, Luiz Carlos Garcez; Guilhem, Dirce; Stepke, Fernando Lolas; Silveira, Carla Cristina Costa; Komatsu, Ricardo Shoiti; Trindade, Eliane Mendonca Vilar; Guiotti, Murilo Galvao



ConDeTri - A Content Dependent Read Trimmer for Illumina Data  

PubMed Central

During the last few years, DNA and RNA sequencing have started to play an increasingly important role in biological and medical applications, especially due to the greater amount of sequencing data yielded from the new sequencing machines and the enormous decrease in sequencing costs. Particularly, Illumina/Solexa sequencing has had an increasing impact on gathering data from model and non-model organisms. However, accurate and easy to use tools for quality filtering have not yet been established. We present ConDeTri, a method for content dependent read trimming for next generation sequencing data using quality scores of each individual base. The main focus of the method is to remove sequencing errors from reads so that sequencing reads can be standardized. Another aspect of the method is to incorporate read trimming in next-generation sequencing data processing and analysis pipelines. It can process single-end and paired-end sequence data of arbitrary length and it is independent from sequencing coverage and user interaction. ConDeTri is able to trim and remove reads with low quality scores to save computational time and memory usage during de novo assemblies. Low coverage or large genome sequencing projects will especially gain from trimming reads. The method can easily be incorporated into preprocessing and analysis pipelines for Illumina data. Availability and implementation Freely available on the web at PMID:22039460

Smeds, Linnea; Kunstner, Axel



Overcoming the aggregation problem: a new type of fluorescent ligand for ConA-based glucose sensing.  


Competitive binding assays based on the lectin Concanavalin A (ConA) have displayed significant potential to serve in continuous glucose monitoring applications. However, to date, this type of fluorescent, affinity-based assay has yet to show the stable, glucose predictive capabilities that are required for such an application. This instability has been associated with the extensive crosslinking between traditionally-used fluorescent ligands (presenting multiple low-affinity moieties) and ConA (presenting multiple binding sites) in free solution. The work herein introduces the design and synthesis of a new type of fluorescent ligand that can avoid this aggregation and allow the assay to be sensitive across the physiologically relevant glucose concentration range. This fluorescent ligand (APTS-MT) presents a single high-affinity trimannose moiety that is recognized by ConA's full binding site and a fluorophore that can effectively track the ligand's equilibrium binding via fluorescent anisotropy. This is confirmed by comparing its measured fluorescent lifetime to experimentally-determined rotational correlation lifetimes of the free and bound populations. Using an assay comprised of 200 nM APTS-MT and 1 µM ConA, the fluorescence anisotropy capably tracks the concentration of monosaccharides that are known to bind to ConA's primary binding site, and the assay displays a MARD of 6.5% across physiologically relevant glucose concentrations. Ultimately, this rationally-designed fluorescent ligand can facilitate the realization of the full potential of ConA-based glucose sensing assays and provide the basis for a new set of competing ligands to be paired with ConA. PMID:25058939

Cummins, Brian M; Li, Mingchien; Locke, Andrea K; Birch, David J S; Vigh, Gyula; Coté, Gerard L



Feeding of grey squirrels (Sciurus carolinensis) with the contraceptive agent DiazaCon™: effect on cholesterol, hematology, and blood chemistry.  


Grey squirrels (Sciurus carolinensis) are an invasive species in Britain and Italy. They have replaced native red squirrels (Sciurus vulgaris) throughout most of Britain, and cause damage to trees. Currently, lethal control is used to manage grey squirrel populations in Britain, but nonlethal methods might be more acceptable to the public. One such method is contraception with 20,25-diazacholesterol dihydrochloride (DiazaCon™). DiazaCon™ inhibits the conversion of desmosterol to cholesterol, resulting in increasing desmosterol concentrations and decreasing cholesterol concentrations. Because cholesterol is needed for the synthesis of steroid reproductive hormones, such as progesterone and testosterone, inhibition of cholesterol synthesis indirectly inhibits reproduction. Desmosterol is used as a marker of efficacy in laboratory studies with species that do not reproduce readily in captivity. Grey squirrels were gavaged with a DiazaCon™ solution for 2 days, and then fed DiazaCon™-coated peanuts for an additional 8 days at target doses of 50 and 100 mg DiazaCon™ per kg body weight. There was a significant difference in cholesterol concentrations in the treatment groups compared to the control group. Cholesterol was reduced by ? 40% for 2 months in both treatment groups. There were no differences among groups with respect to blood chemistry and hematology parameters, and mean values are reported. The mean overall dose of DiazaCon™ received was 29.0 ± 1.6 and 55.3 ± 4.3 mg/kg in the low (50 mg/kg) and high dose (100 mg/kg) groups, respectively. DiazaCon™ might provide an effective, acceptable alternative to lethal control. PMID:22182332

Yoder, Christi A; Mayle, Brenda A; Furcolow, Carol A; Cowan, David P; Fagerstone, Kathleen A



A con-focal setup for micro-XRF experiments using diamond anvil cells  

NASA Astrophysics Data System (ADS)

In this contribution we introduce an experimental setup to perform con-focal micro X-ray fluorescence measurements in situ in samples at high temperatures and pressures in diamond anvil cells (DAC) (e.g. Schmidt et al. 2007). The con-focal arrangement is used to suppress the background in X-ray fluorescence (XRF) spectra that stems from elastic and inelastic scattering of the diamond anvils. The setup is based on a focusing optic in the incident beam that reaches a spot of 5-10 ?m and a focusing poly-capillary in front of an energy-dispersive solid-state detector. The detector poly-capillary is designed to work at a very long working distance of 50 mm in order to collect the radiation from the center of the DAC at 90° to the incident beam. The probing volume is defined by the two foci and has a size of ca. 300 ?m at 8 keV and 150 ?m at 19 keV as measured by scans through thin metal foils. Comparison of XRF spectra acquired with a usual detector collimator and spectra recorded with the detector capillary shows a strong suppression of XRF signal generated outside the probed volume, i.e. XRF from the gasket material and signal from elastic and Compton scattering by the diamond anvils. The ratio of the Zr K-alpha fluorescence peak to the peak of the Compton scattering changes from 0.5 (collimator) to 1.26 (detector capillary) for a ca. 1000 ppm Zr standard solution and an incident beam energy of 20 keV. For a standard solution containing ca. 1000 ppm Hf, the ratio of the L-alpha to the Compton signal increases to 6 using the detector capillary and an incident beam energy of 9.7 keV. Thus, the con-focal setup substantially improves the fluorescence to background ratio. This will result in higher sensitivities for dilute elements in the sample chamber of the DAC. Furthermore, the possibilities of interference of the sample's signal with signal from the sample environment are greatly reduced. In a broader sense, the setup can also be applied to other confined samples that require long working distances. Schmidt et al. (2007) Lithos 95, 87-102

Wilke, Max; Rickers, Karen; Vincze, Laszlo; Schmidt, Christian; Borchert, Manuela; Pascarelli, Sakura



Multi-wall carbon nanotube-polyaniline biosensor based on lectin-carbohydrate affinity for ultrasensitive detection of Con A.  


In this paper, a novel method for detecting concanavalin A (Con A) was developed based on lectin-carbohydrate biospecific interactions. Multi-wall carbon nanotube-polyaniline (MWNT-PANI) nanocomposites, synthesized by in situ polymerization, were chosen to immobilize d-glucose through the Schiff-base reaction. The immobilized D-glucose showed high binding sensitivity and excellent selectivity to its target lectin, Con A. Cyclic voltammetry (CV), electrochemical impedance spectroscopy (EIS), transmission electron microscopy (TEM) and atomic force microscopy (AFM) were applied to characterize the assembly process of the modified electrode. Due to the high affinity of Con A for D-glucose and high stability of the propounded sensing platform, the fabricated biosensor achieved ultrasensitive detection of Con A with good sensitivity, acceptable reproducibility and stability. The changes of response current were proportional to the Con A concentrations from 3.3 pM to 9.3 nM, with a detection limit of 1.0 pM. Therefore, the combination of MWNT-PANI nanocomposites and the special binding force between lectin and carbohydrate provides an efficient and promising platform for the fabrication of bioelectrochemical devices. PMID:22387041

Hu, Fangxin; Chen, Shihong; Wang, Chengyan; Yuan, Ruo; Xiang, Yun; Wang, Cun



Distribución espacial de órbitas con diferentes grados de caoticidad en modelos autoconsistentes de satélites galácticos  

NASA Astrophysics Data System (ADS)

En trabajos anteriores (Carpintero et al., Cel. Mech. Dynam. Astron. 85, 247, 2003), mostramos que las órbitas caóticas son muy importantes en los satélites galácticos. Sin embargo, los únicos modelos autoconsistentes de los que se disponía para ellos eran los de Heggie-Ramamani, cuya función de distribución depende sólo de la energía por lo que no mostraban diferencias entre las distribuciones de sus órbitas regulares y caóticas. Ahora, mediante una aproximación cuadrupolar, hemos logrado construir modelos autoconsistentes de satélites galácticos con distribuciones de velocidades anisotrópicas (lo que indica que sus funciones de distribución no dependen sólo de la energía) y hemos logrado revelar las diferencias entre las estructuras espaciales de las órbitas de distinta caoticidad.

Muzzio, J. C.; Mosquera, M.


Análisis de componentes cognoscitivos y psiquiátricos en pacientes con demencia frontotemporal y alzheimer / Analysis of cognitive and psychiatric components in patients with frontotemporal dementia and Alzheimer.  

E-print Network

??Reyes Gavilán, Pablo Alexander (2010) Análisis de componentes cognoscitivos y psiquiátricos en pacientes con demencia frontotemporal y alzheimer / Analysis of cognitive and psychiatric components… (more)

Reyes Gavilán, Pablo Alexander



Spectral analysis software improves con dence in plant and soil water stable isotope analyses performed by isotope ratio infrared  

E-print Network

Spectral analysis software improves con dence in plant and soil water stable isotope analyses with the types of spectral interference that compromises their stable isotope analysis. Here we report two of stable iso- tope analysis of water. The stable isotope composition of pure water analyzed by IRIS

Goldsmith, Greg


IEEE Wireless Communications February 201382 1536-1284/13/$25.00 2013 IEEE 1 The static power con-  

E-print Network

to green cellular networks. Taking advantage of multicell cooperation, the energy efficiency of cellular (e.g., the grid, solar energy, and wind energy), Han and Ansari [5] proposed to optimize, the energy con- sumption of cellular networks keeps increasing. Therefore, greening cellular networks

Ansari, Nirwan


have to travel normal to the layer structure. The film thickness must be sufficiently small to keep the con-  

E-print Network

the con- tact resistance low (Fig. 3B). 15. M. Shur, M. Hack, J. G. Shaw, J. Appl. Phys. 66, 3371 (1989); M. Shur and M. Hack, ibid. 55, 3831 (1984). 16. G. Horowitz and P. Delannoy, ibid. 70, 469 (1991

Wang, Zhong L.



E-print Network

C ALCULO Y DISE ~NO ASISTIDO POR ORDENADOR DE TOMAS DE TIERRA CON MODELOS DE SUELO NO UNIFORMES suelo no uniformes. La formulacion se ha derivado especialmente para modelos de terreno de dos capas a disposiciones muy simples de los electrodos de tierra en modelos de suelo uniforme, elevados requerimientos

Colominas, Ignasi


Responsables de la UA visitan Bruselas con motivo del programa de investigacin Horizonte 2020 de la UE  

E-print Network

Responsables de la UA visitan Bruselas con motivo del programa de investigación Horizonte 2020 de pasados para preparar la estrategia de la UA de cara a la convocatoria Horizonte 2020. Durante la actividad ha estado acompañada por el director del Secretariado de Investigación de la UA, Enrique Herrero

Escolano, Francisco


Development and Demonstration of a Fault Current Limiting HTS Cable to be Installed in the Con Edison Grid  

Microsoft Academic Search

The US Department of Homeland Security is currently funding the design, development and demonstration of an inherently fault current limiting HTS cable, called Secure Super Grids, under the Hydra project with Con Edison. The cable is 300 m long and is being designed to carry 96 MVA at a distribution level voltage of 13.8 kV. The cable will be built

James Maguire; Doug Folts; Jie Yuan; David Lindsay; Dave Knoll; Shawn Bratt; Zack Wolff; Steve Kurtz



respectively, dust and sea salt aerosols; cloud liquid water and cloud ice mixing ratio; and number con-  

E-print Network

respectively, dust and sea salt aerosols; cloud liquid water and cloud ice mixing ratio; and number con- centrations of cloud droplets and ice crystals. Trans- port, dry, and wet deposition, but instead will likely cause localized ex- tinctions at a series of "hot spots." Patterns of exposure

Blanchette, Carol Anne


iPathCons and iPathDB: an improved insect pathway construction tool and the database  

PubMed Central

Insects are one of the most successful animal groups on earth. Some insects, such as the silkworm and honeybee, are beneficial to humans, whereas others are notorious pests of crops. At present, the genomes of 38 insects have been sequenced and made publically available. In addition, the transcriptomes of dozens of insects have been sequenced. As gene data rapidly accumulate, constructing the pathway of molecular interactions becomes increasingly important for entomological research. Here, we developed an improved tool, iPathCons, for knowledge-based construction of pathways from the transcriptomes or the official gene sets of genomes. Considering the high evolution diversity in insects, iPathCons uses a voting system for Kyoto Encyclopedia of Genes and Genomes Orthology assignment. Both stand-alone software and a web server of iPathCons are provided. Using iPathCons, we constructed the pathways of molecular interactions of 52 insects, including 37 genome-sequenced and 15 transcriptome-sequenced ones. These pathways are available in the iPathDB, which provides searches, web server, data downloads, etc. This database will be highly useful for the insect research community. Database URL: PMID:25388589

Zhang, Zan; Yin, Chuanlin; Liu, Ying; Jie, Wencai; Lei, Wenjie; Li, Fei



Application Instructions The 2014 UTHSC College of Nursing (CON) Application cycle is closed except for the Neonatal Nurse, Adult-  

E-print Network

for the Neonatal Nurse, Adult- Gerontology Acute Care Nurse Practitioner certificate program and RN-BSN programsApplication Instructions The 2014 UTHSC College of Nursing (CON) Application cycle is closed except of the application cycle. Applications for the DNP Nurse Anesthesia (Entry) Program for Summer 2015 admission

Cui, Yan


First International Conference on Industrialized, Intelligent Construction (I3CON) Loughborough University, 14-16 May 2008  

E-print Network

First International Conference on Industrialized, Intelligent Construction (I3CON) Loughborough to be a criticism, of course: Pearce was only following the prevailing ideas of the day, and the end result. The interior atrium of the Eastgate Centre2 . d. A mound of Macrotermes michaelseni in northern Namibia. 2 How

Turner, Scott


Optical negative-index bulk metamaterials con-sisting of 2D perforated metal-dielectric stacks  

E-print Network

Optical negative-index bulk metamaterials con- sisting of 2D perforated metal-dielectric stacks for High Technology Materials and Department of Electrical and Computer Engineering, University of New-infrared negative-index metama- terial (NIM) slab consisting of multiple layers of perforated metal

New Mexico, University of


Studio di risonanza magnetica funzionale delle funzioni attentive in pazienti con danno assonale diffuso dopo trauma cranico  

Microsoft Academic Search

Introduzione Il trauma cranico rappresenta la principale causa di morte e inva- lidità nei soggetti giovani adulti. Si tratta di una condizione patologi- ca caratterizzata da complessi esiti neurologici che coinvolgono, non solo le capacità motorie, ma anche quelle comportamentali e cogni- tive1. I disturbi neuropsicologici rappresentano un grave e costante problema nel paziente post-traumatico, interferendo con i processi di





Microsoft Academic Search

SUMARIO: En todos los niveles de enseñanza las asignaturas relacionadas con la Educación Artística están perdiendo importancia frente a la relevancia de las materias instrumentales. Sin embargo resulta imprescindible la enseñanza en la creatividad y el pensamiento divergente; aspectos que de inmediato nos hacen pensar en la Expresión Plástica. Más allá las enseñanzas artísticas resultan una herramienta ideal para el

José Lobato Suero; Magdalena Martínez; Isabel Molinos Lara


iPathCons and iPathDB: an improved insect pathway construction tool and the database.  


Insects are one of the most successful animal groups on earth. Some insects, such as the silkworm and honeybee, are beneficial to humans, whereas others are notorious pests of crops. At present, the genomes of 38 insects have been sequenced and made publically available. In addition, the transcriptomes of dozens of insects have been sequenced. As gene data rapidly accumulate, constructing the pathway of molecular interactions becomes increasingly important for entomological research. Here, we developed an improved tool, iPathCons, for knowledge-based construction of pathways from the transcriptomes or the official gene sets of genomes. Considering the high evolution diversity in insects, iPathCons uses a voting system for Kyoto Encyclopedia of Genes and Genomes Orthology assignment. Both stand-alone software and a web server of iPathCons are provided. Using iPathCons, we constructed the pathways of molecular interactions of 52 insects, including 37 genome-sequenced and 15 transcriptome-sequenced ones. These pathways are available in the iPathDB, which provides searches, web server, data downloads, etc. This database will be highly useful for the insect research community. Database URL: PMID:25388589

Zhang, Zan; Yin, Chuanlin; Liu, Ying; Jie, Wencai; Lei, Wenjie; Li, Fei



La UA colaborar con el Centro de Parlisis Cerebral Infanta Elena en nuevas tecnologas y Ciencias de Salud  

E-print Network

La UA colaborará con el Centro de Parálisis Cerebral Infanta Elena en nuevas tecnologías y Ciencias Parálisis Cerebral Infanta Elena en materia de nuevas tecnologías y Ciencias de la Salud. Este ha sido el

Escolano, Francisco


Aplicando modelos de granos de polvo con propiedades meteoriticas al continuo ionizante de algunos Nucleos Activos de Galaxias  

E-print Network

We construct extinction curves based on Mie's theory for spherical dust grain with size distributions between 50-2500 A and composed by elements found in meteorites. We explore the issue of whether the observed spectral energy distribution might be dust absorbed in the far and near-UV by this kind of dust grains. Using this approach, satisfactory fits to the 11 spectra can be obtained. ----- En este trabajo, presentamos las diversas curvas de extincion que hemos calculado con base a la teoria Mie para granos de polvo esfericos, con distribuciones de acuerdo a su tamano (entre 50-2500 A) y con diversos compuestos quimicos hallados en meteoritos. Bajo el posible paradigma que hemos desarrollado, estas curvas de extincion al ser aplicadas a un continuo ionizante teorico y comparadas con 11 espectros observados de quasares, hemos encontrado de manera exitosa reproducir tanto el quiebre UV asi como el problema de suavidad presentes en el continuo ionizante de algunos Nucleos Activos de Galaxias.

Haro-Corzo, Sinhue Amos Refugio



Aplicando modelos de granos de polvo con propiedades meteoriticas al continuo ionizante de algunos Nucleos Activos de Galaxias  

E-print Network

We construct extinction curves based on Mie's theory for spherical dust grain with size distributions between 50-2500 A and composed by elements found in meteorites. We explore the issue of whether the observed spectral energy distribution might be dust absorbed in the far and near-UV by this kind of dust grains. Using this approach, satisfactory fits to the 11 spectra can be obtained. ----- En este trabajo, presentamos las diversas curvas de extincion que hemos calculado con base a la teoria Mie para granos de polvo esfericos, con distribuciones de acuerdo a su tamano (entre 50-2500 A) y con diversos compuestos quimicos hallados en meteoritos. Bajo el posible paradigma que hemos desarrollado, estas curvas de extincion al ser aplicadas a un continuo ionizante teorico y comparadas con 11 espectros observados de quasares, hemos encontrado de manera exitosa reproducir tanto el quiebre UV asi como el problema de suavidad presentes en el continuo ionizante de algunos Nucleos Activos de Galaxias.

Sinhue Amos Refugio Haro-Corzo; Luc Binette



Global trade in dairy products involves complex and con-tentious issues. Viewed broadly from the perspective of  

E-print Network

Global trade in dairy products involves complex and con- tentious issues. Viewed broadly from the perspective of "society," there are large benefits from liberalizing trade. Viewed narrowly from the perspective of dairy producers, liberalized trade is desirable only if it expands exports and reduces imports

Radeloff, Volker C.



EPA Science Inventory

An evaluation was performed of the International Waste Technologies (IWT) HWT-20 additive and the Geo-Con, Inc. deep-soil-mixing equipment for an in situ stabilization/solidification process and its applicability as an on-site treatment method for waste site cleanup. emonstration...



EPA Science Inventory

The long-term performance tests provide information on the first follow-up sampling and analysis on the SITE program demonstration of the International Waste Technologies additive, and the Geo-Con deep soil mixing equipment. he samples containing PCBs, were collected one year aft...



EPA Science Inventory

The long-term performance tests provide information on the first follow-up sampling and analysis on the SITE program demonstration of the International Waste Technologies additive, and the Geo-Con deep soil mixing equipment. he samples containing PCBs, were collected one year aft...


LISTADO DE LIBROS SOBRE VIOLENCIA DE GNERO Este listado se corresponde con los libros expuestos en esta Muestra. Han  

E-print Network

LISTADO DE LIBROS SOBRE VIOLENCIA DE G�NERO Este listado se corresponde con los libros expuestos en: libro de estilo para informar en los medios de comunicación sobre la mujer SÁNCHEZ ARANDA, José Javier

Escolano, Francisco


Pros and cons of liver transplantation in human immunodeficiency virus infected recipients  

PubMed Central

Before the introduction of combined highly active antiretroviral therapy, a positive human immunodeficiency virus (HIV) serological status represented an absolute contraindication for solid organ transplant (SOT). The advent of highly effective combined antiretroviral therapy in 1996 largely contributed to the increased demand for SOT in HIV-positive individuals due to increased patients’ life expectancy associated with the increasing prevalence of end-stage liver disease (ESLD). Nowadays, liver failure represents a frequent cause of mortality in the HIV-infected population mainly due to coinfection with hepatitis viruses sharing the same way of transmission. Thus, liver transplantation (LT) represents a reasonable approach in HIV patients with stable infection and ESLD. Available data presently supports with good evidence the practice of LT in the HIV-positive population. Thus, the issue is no longer “whether it is correct to transplant HIV-infected patients”, but “who are the patients who can be safely transplanted” and “when is the best time to perform LT”. Indeed, the benefits of LT in HIV-infected patients, especially in terms of mid- and long-term patient and graft survivals, are strictly related to the patients’ selection and to the correct timing for transplantation, especially when hepatitis C virus coinfection is present. Aim of this article is to review the pros and cons of LT in the cohort of HIV infected recipients. PMID:24833865

Baccarani, Umberto; Righi, Elda; Adani, Gian Luigi; Lorenzin, Dario; Pasqualucci, Alberto; Bassetti, Matteo; Risaliti, Andrea



[Emission spectrum of liquid CO-N2 mixture at shock compression].  


Driving a copper projectile to impact a cryo-target made of aluminous alloy at the speed of 2.21 km x s(-1) with a two stage light gas gun, a proper one dimensional shockwave with a speed of 18.76 km x s(-1) was generated and directly acted on a uniform liquid in target, which was condensed by proportional gaseous carbon monoxide and nitrogen. At the measurement of Hugoniots, the full linear spectrum entirely dissociated with the plasma under the shock pressure of 33.5 GPa was caught by the use of intensified charge coupled device and accurate spectrographic technology. From the analysis of the spectrum, the authors know that the transient spectrograph with six channels can be used to measure and record the course of shock compression-irradiancy reliably, and the emitted spectral lines of shock compressed products indicated that the thermal dissociation and phase transition had occurred in homogeneous liquid of CO-N2. Furthermore, comparing the spectral intensity of lower central wavelength with that of higher, the fact of stronger intensity of 488 nm also validates that changes from "optic thin" to "optic thick" exist indeed in dense hydrocarbon liquid acted on by shock pressure. PMID:19626860

Sun, Yue; Yi, Peng-Fei; Chen, Xian-Meng; Liu, Fu-Sheng; Zhang, Ming-Jian; Zheng, Xue-Ping; Xue, Xue-Dong



Strains arising by seismic events in the SIRGAS-CON network region  

NASA Astrophysics Data System (ADS)

In this study, we investigate surface strains related to seismic events and their relationship with pre- and post-seismic events in Latin America, by analyzing the variation of estimated earth coordinates supplied by a geodetic network called SIRGAS-CON. Based on data provided by the USGS for the period 2000-2011, and after the Global Congruency test, we selected four events associated with unstable geodetic network points. The resulting strains were estimated based on the finite element method using networks of points considered unstable connected to neighboring points using the Delaunay triangulation. It was possible to determine the strains along with the resulting guidelines for pre- and post-seismic, considering each triangular lattice formed for analysis as a homogeneous solid body. The calculation of strains and verification of the results allowed to analyze the interactions between lithospheric plates from the contraction and extension directions between points located in different plates. Despite the association between seismic events and the strain of geodetic network, some events of magnitude greater than 5.8 Mw were excluded because it does not show (provide) the surface strain, which is located at great depths. It was confirmed that events of greater magnitude provide increased surface strain rate when compared with other similar depths.

Marotta, G. S.; França, G. S.; Monico, J. F. G.; Fuck, R. A.



Pro/con ethics debate: is nonheart-beating organ donation ethically acceptable?  


This pro/con debate explores the ethical issues surrounding nonheart-beating organ donation (NHBD), a source of considerable controversy. It is estimated that NHBD can increase the number of organs available for transplant by 25% at a time of great need. However, should NHBD be ethically acceptable? In support of NHBD, it may be acceptable practice if there is a separation of the rationale to withdraw life support/to withhold cardiopulmonary resuscitation from the decision to recover organs, if no conflicts of interest exist, if a waiting time precluding spontaneous return of circulation is included, and if NHBD conforms to a standardized protocol. Against NHBD, there are questions regarding the ambiguity and cultural perspectives of death, regarding whether a separation of rationale between withdrawal and donation is sufficient to preclude conflicts of interest, and regarding whether variable protocols arise that subordinate the patient to the goal of donation. Such concerns suggest NHBD may damage the trust in patient-physician relationships and may adversely affect organ donation rates. PMID:12133176

Whetstine, Leslie; Bowman, Kerry; Hawryluck, Laura



Burnout en médicos y enfermeras y su relación con el constructo de personalidad resistente Burnout in doctors and nurses and their relationship with the construct of hardiness personality  

Microsoft Academic Search

RESUMEN El objetivo de este trabajo fue identificar la presencia, nivel y distribución de los factores que constituyen al síndrome de burnout y su relación con la personalidad resistente, con el fin de de- terminar si este constructo puede ser entendido como un factor de protección que disminuye la probabilidad de que el individuo desarrolle y experimente burnout, además de

María Erika; Ortega Herrera; Godeleva Rosa Ortiz Viveros; Pedro Guillermo Coronel Brizio


Estudio financiado por los NIH indica un aumento de la supervivencia en hombres con cáncer de próstata metastásico que reciben quimioterapia desde el inicio de la terapia hormonal

Los hombres con cáncer de próstata metastásico sensible a las hormonas que recibieron el fármaco quimioterapéutico docetaxel al inicio de la terapia hormonal convencional vivieron más tiempo que los pacientes que recibieron solo terapia hormonal, de acuerdo con los resultados preliminares de un estudio clínico controlado y aleatorizado patrocinado por los Institutos Nacionales de la Salud (NIH).



Microsoft Academic Search

. La fotocorriente inducida por iluminación pulsada, de un capacitor MOS con compuerta de Mo, provisto de ventana óptica, se emplea como monitor de su estado de carga, frente a estímulos químicos con concentraciones crecientes de H2 en N2 de hasta 1000 ppm. Se describen las respuestas inducidas por transporte a la interfaz metal-dieléctrico. Los resultados confirman que la sensibilidad

R. M. Lombardi; R. Aragón


Influencia de las variables psicológicas en el deporte de competición: evaluación mediante el cuestionario Características psicológicas relacionadas con el rendimiento deportivo  

Microsoft Academic Search

El objetivo de esta investigación fue analizar la influencia de variables psicológicas en la consecución de éxito, la continuidad a largo plazo y la ocurrencia de lesiones, en el contexto del deporte de com- petición. Se realizaron tres estudios con judokas, jugadores de fútbol y nadadores, utilizando como ins- trumento de evaluación el cuestionario Características Psicológicas relacionadas con el Rendimiento

Fernando Gimeno; Carmen Pérez-Llantada



Characterization Data Package for Containerized Sludge Samples Collected from Engineered Container SCS-CON-210  

SciTech Connect

This data package contains the K Basin sludge characterization results obtained by Pacific Northwest National Laboratory during processing and analysis of four sludge core samples collected from Engineered Container SCS-CON-210 in 2010 as requested by CH2M Hill Plateau Remediation Company. Sample processing requirements, analytes of interest, detection limits, and quality control sample requirements are defined in the KBC-33786, Rev. 2. The core processing scope included reconstitution of a sludge core sample distributed among four to six 4-L polypropylene bottles into a single container. The reconstituted core sample was then mixed and subsampled to support a variety of characterization activities. Additional core sludge subsamples were combined to prepare a container composite. The container composite was fractionated by wet sieving through a 2,000 micron mesh and a 500-micron mesh sieve. Each sieve fraction was sampled to support a suite of analyses. The core composite analysis scope included density determination, radioisotope analysis, and metals analysis, including the Waste Isolation Pilot Plant Hazardous Waste Facility Permit metals (with the exception of mercury). The container composite analysis included most of the core composite analysis scope plus particle size distribution, particle density, rheology, and crystalline phase identification. A summary of the received samples, core sample reconstitution and subsampling activities, container composite preparation and subsampling activities, physical properties, and analytical results are presented. Supporting data and documentation are provided in the appendices. There were no cases of sample or data loss and all of the available samples and data are reported as required by the Quality Assurance Project Plan/Sampling and Analysis Plan.

Fountain, Matthew S.; Fiskum, Sandra K.; Baldwin, David L.; Daniel, Richard C.; Bos, Stanley J.; Burns, Carolyn A.; Carlson, Clark D.; Coffey, Deborah S.; Delegard, Calvin H.; Edwards, Matthew K.; Greenwood, Lawrence R.; Neiner, Doinita; Oliver, Brian M.; Pool, Karl N.; Schmidt, Andrew J.; Shimskey, Rick W.; Sinkov, Sergey I.; Snow, Lanee A.; Soderquist, Chuck Z.; Thompson, Christopher J.; Trang-Le, Truc LT; Urie, Michael W.



(Con)text-specific effects of visual dysfunction on reading in posterior cortical atrophy  

PubMed Central

Reading deficits are a common early feature of the degenerative syndrome posterior cortical atrophy (PCA) but are poorly understood even at the single word level. The current study evaluated the reading accuracy and speed of 26 PCA patients, 17 typical Alzheimer's disease (tAD) patients and 14 healthy controls on a corpus of 192 single words in which the following perceptual properties were manipulated systematically: inter-letter spacing, font size, length, font type, case and confusability. PCA reading was significantly less accurate and slower than tAD patients and controls, with performance significantly adversely affected by increased letter spacing, size, length and font (cursive < non-cursive), and characterised by visual errors (69% of all error responses). By contrast, tAD and control accuracy rates were at or near ceiling, letter spacing was the only perceptual factor to influence reading speed in the same direction as controls, and, in contrast to PCA patients, control reading was faster for larger font sizes. The inverse size effect in PCA (less accurate reading of large than small font size print) was associated with lower grey matter volume in the right superior parietal lobule. Reading accuracy was associated with impairments of early visual (especially crowding), visuoperceptual and visuospatial processes. However, these deficits were not causally related to a universal impairment of reading as some patients showed preserved reading for small, unspaced words despite grave visual deficits. Rather, the impact of specific types of visual dysfunction on reading was found to be (con)text specific, being particularly evident for large, spaced, lengthy words. These findings improve the characterisation of dyslexia in PCA, shed light on the causative and associative factors, and provide clear direction for the development of reading aids and strategies to maximise and sustain reading ability in the early stages of disease. PMID:24841985

Yong, Keir X.X.; Shakespeare, Timothy J.; Cash, Dave; Henley, Susie M.D.; Warren, Jason D.; Crutch, Sebastian J.



Iliac crest autograft versus alternative constructs for anterior cervical spine surgery: Pros, cons, and costs  

PubMed Central

Background: Grafting choices available for performing anterior cervical diskectomy/fusion (ACDF) procedures have become a major concern for spinal surgeons, and their institutions. The “gold standard”, iliac crest autograft, may still be the best and least expensive grafting option; it deserves to be reassessed along with the pros, cons, and costs for alternative grafts/spacers. Methods: Although single or multilevel ACDF have utilized iliac crest autograft for decades, the implant industry now offers multiple alternative grafting and spacer devices; (allografts, cages, polyether-etherketone (PEEK) amongst others). While most studies have focused on fusion rates and clinical outcomes following ACDF, few have analyzed the “value-added” of these various constructs (e.g. safety/efficacy, risks/complications, costs). Results: The majority of studies document 95%-100% fusion rates when iliac crest autograft is utilized to perform single level ACDF (X-ray or CT confirmed at 6-12 postoperative months). Although many allograft studies similarly quote 90%-100% fusion rates (X-ray alone confirmed at 6-12 postoperative months), a recent “post hoc analysis of data from a prospective multicenter trial” (Riew KD et. al., CSRS Abstract Dec. 2011; unpublished) revealed a much higher delayed fusion rate using allografts at one year 55.7%, 2 years 87%, and four years 92%. Conclusion: Iliac crest autograft utilized for single or multilevel ACDF is associated with the highest fusion, lowest complication rates, and significantly lower costs compared with allograft, cages, PEEK, or other grafts. As spinal surgeons and institutions become more cost conscious, we will have to account for the “value added” of these increasingly expensive graft constructs. PMID:22905321

Epstein, Nancy E.



Do Patient-perceived Pros and Cons of Opioids Predict Sustained Higher-Dose Use?  

PubMed Central

Objectives Chronic opioid therapy (COT) is associated with various adverse outcomes, especially at higher doses, yet little is known about predictors of sustained higher-dose COT. This study aimed to ascertain, among higher-dose COT patients, the association of patient-perceived pros and cons of opioids with continued higher-dose use 1 year later. Methods Patients (N = 1229) in 2 large health plans prescribed ? 50 mg morphine-equivalent dose (MED) per day for chronic non-cancer pain completed a survey assessing opioid benefits and harms. The Prescribed Opioid Difficulties Scale questionnaire assessed psychosocial problems, concerns, benefits, and side effects related to opioid use. Logistic regression models estimated the associations of the reported benefits and problems with higher-dose continuation (? 50 mg MED/d) versus dose reduction (< 50 mg MED/d) 1 year later. Results Over 80% of participants continued higher-dose opioid use at 1 year, regardless of reported problems, concerns, side effects, pain reduction, or perceived helpfulness. Higher scores on the Prescribed Opioid Difficulties Scale Problems subscale (odds ratio = 0.79, 95% confidence interval, 0.68–0.92) and Concerns subscale (odds ratio = 0.76, 95% confidence interval, 0.65–0.90) were negatively associated with higher-dose use 1 year later. Other baseline measures (opioid helpfulness, reduction in pain, number of side effects, and side effect bothersomeness) were not significantly associated with continued higher-dose use. Discussion The large majority of patients continued using higher-dose opioids regardless of baseline characteristics. These findings suggest the difficulty of reducing opioid dose among chronic higher-dose opioid users. PMID:23535150

Thielke, Stephen M.; Turner, Judith A.; Shortreed, Susan M.; Saunders, Kathleen; LeResche, Linda; Campbell, Cynthia I.; Weisner, Constance C.; Korff, Michael V.



(Con)text-specific effects of visual dysfunction on reading in posterior cortical atrophy.  


Reading deficits are a common early feature of the degenerative syndrome posterior cortical atrophy (PCA) but are poorly understood even at the single word level. The current study evaluated the reading accuracy and speed of 26 PCA patients, 17 typical Alzheimer's disease (tAD) patients and 14 healthy controls on a corpus of 192 single words in which the following perceptual properties were manipulated systematically: inter-letter spacing, font size, length, font type, case and confusability. PCA reading was significantly less accurate and slower than tAD patients and controls, with performance significantly adversely affected by increased letter spacing, size, length and font (cursive < non-cursive), and characterised by visual errors (69% of all error responses). By contrast, tAD and control accuracy rates were at or near ceiling, letter spacing was the only perceptual factor to influence reading speed in the same direction as controls, and, in contrast to PCA patients, control reading was faster for larger font sizes. The inverse size effect in PCA (less accurate reading of large than small font size print) was associated with lower grey matter volume in the right superior parietal lobule. Reading accuracy was associated with impairments of early visual (especially crowding), visuoperceptual and visuospatial processes. However, these deficits were not causally related to a universal impairment of reading as some patients showed preserved reading for small, unspaced words despite grave visual deficits. Rather, the impact of specific types of visual dysfunction on reading was found to be (con)text specific, being particularly evident for large, spaced, lengthy words. These findings improve the characterisation of dyslexia in PCA, shed light on the causative and associative factors, and provide clear direction for the development of reading aids and strategies to maximise and sustain reading ability in the early stages of disease. PMID:24841985

Yong, Keir X X; Shakespeare, Timothy J; Cash, Dave; Henley, Susie M D; Warren, Jason D; Crutch, Sebastian J



[Clinico-pathological conference report: sudden deterioration of general condition, hypokalemia and diabetes in an elderly man].  


An elderly man had been treated for prostate cancer with radiation and neoadjuvant hormonal therapy. One year after the cessation of radiation therapy, the PSA value was found to be elevated. A non-steroidal antiandrogen bicalutamide was initiated to the patient. Due to poor treatment response the drug was changed for the GnRH agonist leuprorelin acetate, which upon injection caused a sudden deterioration of the patient's general condition. He was delirious and in pain, and was diagnosed with leukocytosis, hypokalemia, hyperglycemia and metabolic alkalosis. The patient was referred to the endocrinological clinic for evaluation of the metabolic-endocrinological problems. He succumbed to disseminated prostate cancer. PMID:22937608

Metso, Saara; Arola, Johanna; Raade, Merja; Välimäki, Matti



Clinico-histopathologic and outcome features of cutaneous infundibular keratinizing acanthoma: a case report and literature review  

PubMed Central

The infundibular keratinizing acanthoma (IKA) is a rare epithelial benign keratin-containing neoplasm of hair follicles. The purpose of this study was to evaluate the defining histopathologic architecture of IKA. A typical IKA consisted of a keratin-filled crypt in the dermis and subcutis that opened to the skin surface. Most of this tumor occurred on the back, neck, head, and the shoulders. Microscopically, the dermal nodules were focally contiguous in both the dermis and subcutis. Furthermore, most histological lesions are consistent with a simple or multiloculated cyst filled with keratin and lined by a wall of stratified squamous epithelium; keratin appears as a concentric lamellar mass, with a keratotic pearly aspect. Histological examination of the cutaneous lesions revealed that the growths were comprised of IKA. IKA of man and dog were compared, and it was concluded that although they are similar in many respects, they are not identical entities. To the best of our knowledge, this is the first report on the prevalence of IKAs among the population of owned dogs in Iran. PMID:24890648



Clinico-Pathological Profile of Adnexal Torsion Cases: A Retrospective Analysis from A Tertiary Care Teaching Hospital  

PubMed Central

Introduction: Torsion of the adnexa is a rare condition which can be potentially lethal for the women. The clinical presentation can be varied and can be seen in any age group. Understanding the clinical and pathological profile of patients suffering from adenexal torsion can guide the clinicians in diagnosing and managing the condition. Objective: To analyze the clinical and pathological profile of adnexal torsion cases in a tertiary care teaching hospital. Materials and Methods: The study was a retrospective analysis of hospital records. It included all cases of adnexal torsion that underwent laprotomy between January 2007 to December 2012 in a tertiary care teaching hospital. The study was approved by the Institute’s human Ethics Committee. Results: A total of 18 patients were included in the study. Majority (66.7%) of participants were in the reproductive age group. Abdominal pain was the most common symptom seen in 77.8% of patients. The other symptoms were abdominal distension, back ache and dysuria. Majority of the women belonged to Para 2 (44.4%) and Para 3 (27.8%). The proportion of women with one and two LSCS was 11.1% and 16.7% respectively. Tenderness (38.9%), mass (22.2%) were the common per abdomen findings. Perspeculum findings were normal in majority (88.9%) of the participants. About 39.2% of the patients presented with a mass in either fornices or pouch of Douglas on pervaginal examination. The side of lesion was only on right in 9 (50%) , only left in 7(38.9%) and both sides in 2 (11.1%) of cases. On histopathological examination, of the lesions there were mucinous cystadenoma (33.3%) serous cystadenoma (16.7%) and benign cystic teratoma (16.7%) as most common lesions. Conclusion: Adnexal torsion, though a rare clinical condition can present as an emergency most of the times. High index of suspicion is required for diagnosis, as the clinical presentation can be varied. But the diagnosis can be made certain only on the operating table, either by laparoscopy. Avoiding a delay in operating upon the patient will help prevent complications, and aid in conserving the ovary. PMID:25121032

Reddy, Gopireddy Murali Mohan; Subbiah, Vasantha Nagamma; Sathiya, Saktivel; Arjun, Balasubramanian



Ocular surface squamous neoplasia - Review of etio-pathogenesis and an update on clinico-pathological diagnosis  

PubMed Central

Ocular surface squamous neoplasia (OSSN) has a varied clinical presentation, the diagnosis of which rests on the histopathological examination of the excised lesion. The term OSSN includes mild dysplasia on one end of the spectrum and invasive squamous cell carcinoma on the other end. This lesion has a multi factorial aetiology with interplay of several factors like exposure to ultraviolet radiation, various chemical carcinogens and viral infections, however role of individual agents is not well understood. With the upsurge of infection with human immunodeficiency virus, a changing trend is seen in the clinical presentation and prognosis of patients of OSSN even in developed countries. Anterior segment optical coherence tomography (OCT) and confocal microscopy, hold promise in in-vivo differentiation of intraepithelial neoplasia from invasive squamous cell carcinoma. Variants of squamous cell carcinoma like Mucoepidermoid carcinoma, spindle cell carcinoma and OSSN associated with HIV infection should be suspected in a case of aggressive clinical presentation of OSSN or with massive and recurrent tumours. Surgery, chemotherapy and immunotherapy are the various treatment modalities which in combination show promising results in aggressive, recurrent and larger tumours. PMID:24227983

Mittal, Ruchi; Rath, Suryasnata; Vemuganti, Geeta Kashyap



Assessment of clinico-immunological profile of newly diagnosed HIV patients presenting to a teaching hospital of eastern India  

PubMed Central

Background & objectives: Newly diagnosed HIV patients may be asymptomatic or present with a wide range of symptoms related to opportunistic infections, acute seroconversion illness or other medical illnesses. This study was designed to evaluate the socio-demographic parameters, spectrum of the presenting clinical conditions and concurrent immunological status of newly diagnosed HIV patients and document the WHO clinical stages at the time of HIV diagnosis. Methods: This cross-sectional, observational study was undertaken over a 12 month period at a tertiary referral hospital in eastern India. Three hundred sixty consecutive newly diagnosed HIV patients were selected for the study from the HIV clinic and medicine wards of this hospital. Demographic and clinical data and relevant laboratory investigations of the patients were recorded and analyzed. Results: Mean age of patients was 36.38 ± 10.62 yr, while 63.89 per cent were males. The main mode of transmission of HIV for males and females were unprotected exposure to commercial sex (139, 60.44%) and intercourse with HIV seropositive spouses (89, 68.46%), respectively. Fever (104, 28.89%), weight loss (103, 28.61%) and generalized weakness (80, 22.22%) were the predominant symptoms. Overall mean CD4 count was 176.04 ± 163.49 cells/?l (males 142.19 ± 139.33 cells/?l; females 235.92 ± 185.11 cells/?l). Overall, 224 opportunistic infections were documented in 160 patients, opportunistic diarrhoea (44, 12.22%) and pulmonary tuberculosis (39, 10.83%) being the commonest. There were 83 and 133 patients in WHO clinical stages 3 and 4, respectively; 291 (80.83%) patients were eligible for initiation of first-line antiretrovirals at presentation. Interpretation & conclusions: Advanced immunodeficiency and burden of opportunistic infections characterize newly diagnosed HIV patients in eastern India. The physicians should keep in mind that these patients may have more than one clinical condition at presentation. PMID:25109725

Bishnu, Saptarshi; Bandyopadhyay, Dipanjan; Samui, Samiran; Das, Indrani; Mondal, Pradip; Ghosh, Pramit; Roy, Deeptarka; Manna, Sukanta



Some clinico-pathological changes associated with the aqueous extract of the leaves of Phyllanthus amarus in rats.  


The pathological changes of the aqueous crude extract of the leaves of Phyllanthus amarus were studied in 32 male rats over a period of 30 days. The animals were divided into four groups of eight animals per group. The aqueous crude extract was prepared and administered orally using a cannula to rats in three groups receiving doses of 400 mg/kg, 800 mg/kg and 1,000 mg/kg but the fourth group served as a control and received distilled water only. Blood samples were collected for haematological and serum biochemical analysis. Organs such as the liver, kidney, testes and pancreas were also assessed for histopathological changes. The study showed that the extract caused a decrease in the red blood cell (RBC) count, packed cell volume (PCV), haemoglobin concentration (Hb), but an increase in the white blood cell (WBC) count. The extract also resulted in an increase in the levels of aspartate amino transferase (AST), total and conjugated bilirubin, total protein and albumin. The study, however, caused a decrease in the level of alanine amino transferase (ALT). Histopathologically, there were cases of protein casts in the kidney tubules with tubular nephrosis, foci of lymphocytic infiltration at the portal areas of the liver as well as marked testicular degeneration with severe disorganization of seminiferous tubules, which were devoid of spermatic cells. A reduction in the weight of the experimental animals was also noted in this study. It thus shows that Phyllanthus amarus has potential toxic properties. PMID:16317655

Adedapo, A A; Adegbayibi, A Y; Emikpe, B O



[A clinico-histological study for the diagnosis and classification of spontaneous periodontal diseases in the dog].  


Using standardized investigation methods periodontal parameters were proved for diagnostic application of spontaneous periodontal diseases in dogs. The diseases are classified in gingivitis simplex, g. granulomatosa, g. ulcerosa, g. hyperplastica, g. desquamativa, juvenile periodontitis, rapidly progressive p. and chronic p. This proposal can be used for further investigations in experimental dentistry and for therapeutic purposes in veterinary dentistry. PMID:1420662

Hoffmann, T; Gängler, P; Jungmann, D



Quantitative DNA methylation analyses reveal stage dependent DNA methylation and association to clinico-pathological factors in breast tumors  

PubMed Central

Background Aberrant DNA methylation of regulatory genes has frequently been found in human breast cancers and correlated to clinical outcome. In the present study we investigate stage specific changes in the DNA methylation patterns in order to identify valuable markers to understand how these changes affect breast cancer progression. Methods Quantitative DNA methylation analyses of 12 candidate genes ABCB1, BRCCA1, CDKN2A, ESR1, GSTP1, IGF2, MGMT, HMLH1, PPP2R2B, PTEN, RASSF1A and FOXC1 was performed by pyrosequencing a series of 238 breast cancer tissue samples from DCIS to invasive tumors stage I to IV. Results Significant differences in methylation levels between the DCIS and invasive stage II tumors were observed for six genes RASSF1A, CDKN2A, MGMT, ABCB1, GSTP1 and FOXC1. RASSF1A, ABCB1 and GSTP1 showed significantly higher methylation levels in late stage compared to the early stage breast carcinoma. Z-score analysis revealed significantly lower methylation levels in DCIS and stage I tumors compared with stage II, III and IV tumors. Methylation levels of PTEN, PPP2R2B, FOXC1, ABCB1 and BRCA1 were lower in tumors harboring TP53 mutations then in tumors with wild type TP53. Z-score analysis showed that TP53 mutated tumors had significantly lower overall methylation levels compared to tumors with wild type TP53. Methylation levels of RASSF1A, PPP2R2B, GSTP1 and FOXC1 were higher in ER positive vs. ER negative tumors and methylation levels of PTEN and CDKN2A were higher in HER2 positive vs. HER2 negative tumors. Z-score analysis also showed that HER2 positive tumors had significantly higher z-scores of methylation compared to the HER2 negative tumors. Univariate survival analysis identifies methylation status of PPP2R2B as significant predictor of overall survival and breast cancer specific survival. Conclusions In the present study we report that the level of aberrant DNA methylation is higher in late stage compared with early stage of invasive breast cancers and DCIS for genes mentioned above. PMID:24093668



A ten-year review of ruptured sinus of valsalva: clinico-pathological and echo-Doppler features.  


Rupture of the sinus of valsalva (RSOV) is an uncommon condition with a variety of manifestations ranging from an asymptomatic murmur to cardiogenic shock. This retrospective 10-year review (1985-1995) of 18 patients from a single institution revealed that 6 (33%) were female and 12 (67%) were male with a mean age of 37.6 +/- 13.4 years and that 72% were Chinese by ethnic descent with the remaining 28% being Malay. Eight patients (44.4%) presented with an asymptomatic murmur, 4 (22.2%) with acute chest pain, 4 (22.2%) with mild heart failure, 2 (11.1%) with severe heart failure, and 2 (11.1%) with cardiogenic shock. Rupture of the right aneurysmal coronary cusp (RCC) made up 15 (83.3%) while those of the non-coronary cusp (NCC) made up the remaining. Most of the RCC ruptures were directed into the right ventricle and all of the NCC ruptures were into the right atrium. Ventricular septal defects (VSDs) were found in 9 (50%) of the patients, (although detected by echocardiography in only one third of those patients), aortic regurgitation in 6 (33.3%) and aortic valve vegetations in 2 (11.1%). Echocardiography was found to be accurate in diagnosing RSOVs with 100% diagnostic accuracy after 1990 with four misdiagnoses before 1990. Of these four patients, two were misdiagnosed as having VSDs, one as having a coronary arteriovenous fistula and one as having a patent ductus arteriosus. The anatomical structure of the "windsock" was seen in 64% of the patients who were correctly diagnosed. The pattern of colour flow and spectral Doppler was seen in all patients and helped to localise the site of rupture and the direction of flow. In summary, echocardiography is a simple and accurate way of diagnosing and defining RSOVs and is the imaging modality of choice. PMID:11874151

Shah, R P; Ding, Z P; Ng, A S; Quek, S S



Low grade Endometrial Stromal Sarcoma of uterine corpus, a clinico-pathological and survey study in 14 cases  

Microsoft Academic Search

BACKGROUND: Endometrial stromal sarcoma (ESS) is a rare disease with probably less than 700 new cases in the USA or Europe per year. The aim of this study was to evaluate the behavior of low-grade endometrial stromal sarcoma (LGESS) in relation to their clinical and pathological features and to identify possible prognostic factors. PATIENTS AND METHODS: Fourteen patients with histologically

Tahereh Ashraf-Ganjoei; Nadereh Behtash; Mamak Shariat; Asamosadat Mosavi



Molecular profiles of BRCA1-mutated and matched sporadic breast tumours: relation with clinico-pathological features  

Microsoft Academic Search

About 5–10% of breast cancers are hereditary; a genetically and clinically heterogeneous disease in which several susceptibility genes, including BRCA1, have been identified. While distinct tumour features can be used to estimate the likelihood that a breast tumour is caused by a BRCA1 germline mutation it is not yet possible to categorize a BRCA1 mutated tumour. The aim of the

E M J J Berns; I L van Staveren; L Verhoog; A M W van de Ouweland; M Meijer-van Gelder; H Meijers-Heijboer; H Portengen; J A Foekens; L C J Dorssers; J G M Klijn



Experimentally induced tick toxicosis in rats bitten by Ornithodoros brasiliensis (Chelicerata: Argasidae): a clinico-pathological characterization.  


Ornithodoros brasiliensis, also known as the mouro tick, is an argasid tick only found in the highlands of Southern Brazil. O. brasiliensis parasitism is associated with severe reactions in its hosts ranging from local pruritus and pain to systemic disturbances. Recently, the re-emergence of O. brasiliensis parasitism in humans and dogs drew attention to the clinical findings induced by its bite, which are poorly understood and described. Moreover, rare experimental data about tick bite effects under controlled conditions were available. Thus, this study aimed to describe clinical and pathological findings induced by O. brasiliensis bites in experimentally parasitized rats. Ticks feed for ?40 min in rats, and their weight increased by approximately four times after the blood meal. Rats bitten by five adult ticks showed hyperemia of the oral/ocular mucosa, piloerection, tachypnea, claudication, ocular and nasal discharge, pruritus, and swollen and erythemic lesions. A large hemorrhagic lesion was observed on rat skin in tick attachment sites, reaching ?17 mm in diameter 12 h after a bite. Bitten rats also presented an increased bleeding tendency (?50%) 6 h after a tick bite, evaluated by the tail-cut rat model of bleeding. Blood samples of bitten rats were taken, and clinical pathology analysis showed significant alterations in the eosinophil and basophil counts, in creatine phosphokinase (CPK) and CPK MB fraction, and lactate dehydrogenase (LDH) activity, and fibrinogen level. Histopathological analysis revealed marked subcutaneous hemorrhage, edema and slight muscle degeneration at the bite site. Also, muscle degeneration and necrosis were observed in the myocardium of bitten rats 72 h after bites by histopathology and immunohistochemistry against troponin C. This work showed the ability of O. brasiliensis to cause severe disturbances in experimentally parasitized rats, compatible with a tick toxicosis syndrome. This observation associated with the re-emergence of O. brasiliensis parasitism makes this parasite as a public health hazard in southern Brazil. PMID:24973739

Reck, José; Bandarra, Paulo; Pavarini, Saulo; Termignoni, Carlos; Driemeier, David; Martins, João Ricardo; Guimarães, Jorge A



Ruolo clinico della tomografia a bioimpedenza extracellulare (Gastro-Mida x ®) nella diagnosi delle patologie del colon retto  

Microsoft Academic Search

Aim. Gastro-Midax® is a non-invasive diagnostic medical device which carries out an extracel- lular bioimpedance tomographic analysis of the colorectal region with a neural technique interpretation using artificial neural networks to diagnose colorectal diseases. The aim of this spontaneous study carried out in various cen- tres in Italy was to train Gastro-Midax® to di- stinguish normal patients from those with



The Clinico-Oncologic Outcomes of Elderly Patients with Glioblastoma after Surgical Resection Followed by Concomitant Chemo-Radiotherapy  

PubMed Central

Background There have been controversies in the treatment of elderly patients with glioblastoma. We introduce the outcome of the treatment of elderly patients with glioblastoma comparing with younger patients. Methods The author's hospital database was used to identify patients with histologically confirmed glioblastoma after surgery between January 2006 and December 2013. Forty-eight patients (control group) were under age 65 and 16 patients (elderly group) were aged 65 years or over at the time of surgery. Results The median age of the elderly group was 71 years and control group was 50 years. Mean number of medical comorbidities was 1.8 in the elderly group vs. 0.5 in the control group. The median progression free survival (PFS) was 5.6 months and the median overall survival (OS) was 19.9 months in all patients. The elderly group had a median PFS of 4.2 months vs. 8 months for the control group (log-rank test, p=0.762). Median OS was 8.2 months in the elderly group vs. 20.9 months in the control group (log-rank test, p=0.457). Major complications occurred in 5 cases (7.8%) for all patients. The ratio of completion of concomitant chemo-radiotherapy (CCRT) was 81.3% and was the same between the two groups. In multivariable analysis, extent of resection (p=0.034) and completion of CCRT (p=0.023) were statistically significant, independent prognostic factors only for PFS in all patients by Cox proportional hazards model. Age was not an independent prognostic factor. As for OS, there was no significant factor. Conclusion Surgical resection and CCRT were well tolerated in elderly patients with glioblastoma, and maximal safe resection followed by timely CCRT could improve clinic-oncologic outcomes.

Park, Hee-Kwon; Song, Sang Woo



An eight-year snapshot of geospatial cancer research (2002–2009): clinico-epidemiological and methodological findings and trends  

Microsoft Academic Search

Geographic information systems (GIS) offer a very rich toolbox of methods and technologies, and powerful research tools that\\u000a extend far beyond the mere production of maps, making it possible to cross-link and study the complex interaction of disease\\u000a data and factors originating from a wide range of disparate sources. Despite their potential indispensable role in cancer\\u000a prevention and control programmes,

Dina N. Kamel Boulos; Ramy R. Ghali; Ezzeldin M. Ibrahim; Maged N. Kamel Boulos; Philip AbdelMalik


A multilocular radiolucency of mandible as the first evidence of multiple myeloma: A clinico-radiographic case report  

PubMed Central

The incidence of multiple myeloma (MM) affecting the jaws is 30% and on rare occasions the oral involvement can be the first indication of the disease. Authors report a case of MM in a 40-year-old woman who presented with a multilocular radiolucent lesion in the left mandible initially mistaken as an ameloblastoma. Conventional radiographs revealed a multilocular lesion on the molar region. Computed tomography (CT) and 3 dimensional CT revealed lytic, space occupying lesion perforating the inferior cortex. Magnetic resonance imaging (MRI) revealed a hypointense lesion on T1 weighted image and hyperintense lesion on T2 weighted image. Histopathological and lab investigations lead to the diagnosis of MM. MRI is superior in depicting the size of the lesion as compared to CT and conventional radiographs. PMID:24932201

Mohan, Ravi Prakash Sasankoti; Gill, Navneet; Verma, Sankalp; Chawa, Venkateshwar Rao; Tyagi, Kuber; Agarwal, Neha



Assessment of Lipid Peroxides in Multiple Biofluids of Leukoplakia and Oral Squamous Cell Carcinoma Patients-A Clinico- Biochemical Study  

PubMed Central

Background: Oral pre cancer and oral cancer results in lipid peroxidation, and assessment of lipid peroxides in body fluids may give insights into the role of anti oxidants in its management. Aim: The study was conducted to discern the varying levels of lipid peroxides in saliva, serum and tissue in oral pre cancer and oral cancer and also various forms of tobacco usage with sex as an added parameter. Materials and Methods: The levels of lipid peroxides were measured in saliva, serum and tissue in a total of 50 patients, 20 belonging to control, and 30 study group in which 10 with oral leukoplakia and 20 with histologically proven oral squamous cell carcinoma (OSCC). The mean value of malondialdehyde (MDA) were also recorded in males and females among the patients with oral leukoplakia and OSCC. Among the study group patients, the levels of MDA were also recorded in habits of smoking and chewing tobacco. Statistical analysis used: Student’s independent t-test, one way ANOVA, Tukey HSD procedure. Results: Significantly elevated levels of lipid peroxides were seen in saliva, serum and tissue in oral leukoplakia and OSCC when compared to control patients. Among the study group, there were statistically significant increased levels of MDA in OSCC when compared to oral leukoplakia. There was also increase in MDA level in patients with smoking and chewing, but the variations seen in males and females were not very significant. Conclusion: The results clearly indicate the increase in lipid peroxidation in oral pre cancer and oral cancer with no significant difference between gender groups. The role of saliva as a relatively risk free and reliable, easy to obtain biofuid for diagnostic purposes has been highlighted. Also, since the levels of antioxidants are drastically decreased in carcinogenesis, the importance of anti oxidant supplements in the early stages of the disease has also been elucidated. PMID:25302269

Kumar N, Gautham



Sexually transmitted diseases and sexual lifestyles of long-distance truck drivers: a clinico-epidemiologic study in south India.  


Our study objective was to determine the prevalence and pattern of sexually transmitted diseases (STDs) and to study sexual lifestyles of long-distance truck drivers and their assistants in south India. For this, a total of 263 truck drivers/assistants were recruited from the highway clinic from October 1999 to March 2001. All of them were sexually active and heterosexual contact was the predominant mode (99.2%). Two-thirds of them had contact with commercial sex workers (CSWs) and roughly 60% admitted alcohol consumption. One hundred and two participants (38.7%) had various STDs. The positivity rates of HIV, VDRL and HBsAg were 15.9%, 13.3% and 21.2% respectively. The higher median age, education less than primary school level, longer duration of occupation, longer duration of each trip and a previous history of genital ulcer disease were significant risk factors for the acquisition of HIV infection. PMID:12230925

Manjunath, J V; Thappa, D M; Jaisankar, T J





Since the publishing of The Bethesda System for Reporting Thyroid Cytopathology (TBSRTC) in 2008, many countries have adopted the system and the results have been reported. In Korea, TBSRTC has been used officially since 2010 and the results are being reported. In this short course, I plan to discuss the systems pros and cons based on our experience.The pros are that the system issues recommendation for treatment or follow-up and malignant ratio for each category, and that the system uses uniform terminology which offers easy and accurate communication and enhances reliable sharing of data. The cons are that because the issued malignant ratio is not a real data and it is actually different in every institution, the offered recommendation needs to be accommodated. PMID:25188060

Hong, Soon Won



El Parque Municipal de El Campello exhibe Las Meninas realizadas con material reciclado por profesores de la Universidad de Alicante  

E-print Network

reutilizados con el objetivo de fomentar el reciclaje a través del arte. La inauguración de la muestra contó exposición viva". Vida/reciclaje versus muerte/no reciclaje El hilo conductor de la exposición, realizada por (ingeniero industrial), todos ellos de la Universidad de Alicante, es transmitir el mensaje de la vida/reciclaje

Escolano, Francisco


Con A-Propagated, Auto-Reactive T Cell Clones that Secrete Factors Promoting High IgA Responses  

Microsoft Academic Search

Four BALB\\/c T cell clones from among a set propagated in the presence of concanavalin A (Con A) were selected on the basis of their ability to produce supernatant factors promoting high IgA plaque-forming cell (PFC) responses by 2,4,6-trinitrophenyl-conjugated keyhole limpet hemocyanin (TNP-KLH)-primed splenic B cells in the presence of TNP-SRBC. Such clones could be derived from cultures containing T

Azzam Al Maghazachi; Julia M. Phillips-Quagliata



Effetti di un trattamento cinesiterapico e idrocinesiterapico termale in pazienti con osteoporosi post-menopausale: studio randomizzato controllato  

Microsoft Academic Search

Introduzione L'Osteoporosi è un vero e proprio problema sociale ed economi- co destinato a diventare sempre più importante con il progressivo invecchiamento della popolazione i cui costi sono legati soprattutto alla gestione delle complicanze (fratture)1 e all'impatto dei loro fre- quenti esiti disabilitanti sulle attività della vita quotidiana che, soprattutto nell'anziano, possono sfociare in uno stato di non-auto- sufficienza cronica2.



Proteja su almuerzo de los grmenes Lvese las manos con agua caliente y jabn antes de preparar el almuerzo.  

E-print Network

Proteja su almuerzo de los gérmenes · Lávese las manos con agua caliente y jabón antes de preparar botella térmica de boca ancha. Vierta agua hirviendo en la botella para calentar el interior. Luego caliente el alimento a 1650 F. Vacíe el agua caliente de la bo- tella y vierta en su interior el alimento


Disminución de las tasas de cáncer de seno relacionada con la reducción del uso de terapias de reemplazo hormonal

La tasa de los casos nuevos de cáncer de seno en los Estados Unidos, la cual disminuyó pronunciadamente en 2003, podría estar relacionada con una disminución nacional del uso de terapias de reemplazo hormonal. Las tasas de incidencia de cáncer de seno ajustadas a la edad en mujeres de los Estados Unidos bajaron un 6.7 por ciento en 2003. Durante este mismo período, las recetas médicas para terapias de reemplazo hormonal bajaron rápidamente.


Mitochondria-Dependent Apoptosis of Con A-Activated T Lymphocytes Induced by Asiatic Acid for Preventing Murine Fulminant Hepatitis  

PubMed Central

Selectively facilitating apoptosis of activated T cells is essential for the clearance of pathogenic injurious cells and subsequent efficient resolution of inflammation. However, few chemicals have been reported to trigger apoptosis of activated T cells for the treatment of hepatitis without affecting quiescent T cells. In the present study, we found that asiatic acid, a natural triterpenoid, selectively triggered apoptosis of concanavalin A (Con A)-activated T cells in a mitochondria-dependent manner indicated by the disruption of the mitochondrial transmembrane potential, release of cytochrome c from mitochondria to cytosol, caspases activation, and cleavage of PARP. In addition, asiatic acid also induced the cleavage of caspase 8 and Bid and augmented Fas expression in Con A-activated T cells. However, following activation of T cells from MRLlpr/lpr mice with mutation of Fas demonstrated a similar susceptibility to asiatic acid-induced apoptosis compared with normal T cells, suggesting that Fas-mediated death-receptor apoptotic pathway does not mainly contribute to asiatic acid-induced cell death. Furthermore, asiatic acid significantly alleviated Con A-induced T cell-dependent fulminant hepatitis in mice, as assessed by reduced serum transaminases, pro-inflammatory cytokines, and pathologic parameters. Consistent with the in vitro results, asiatic acid also induced apoptosis of activated CD4+ T cells in vivo. Taken together, our results demonstrated that the ability of asiatic acid to induce apoptosis of activated T cells and its potential use in the treatment of T-cell-mediated inflammatory diseases. PMID:23029367

Guo, Wenjie; Liu, Wen; Hong, Shaocheng; Liu, Hailiang; Qian, Cheng; Shen, Yan; Wu, Xuefeng; Sun, Yang; Xu, Qiang



Integrated Concentration in Science (iCons): Undergraduate Education Through Interdisciplinary, Team-Based, Real-World Problem Solving  

NASA Astrophysics Data System (ADS)

Attitude, Skills, Knowledge (ASK) -- In this order, these are fundamental characteristics of scientific innovators. Through first-hand practice in using science to unpack and solve complex real-world problems, students can become self-motivated scientific leaders. This presentation describes the pedagogy of a recently developed interdisciplinary undergraduate science education program at the University of Massachusetts Amherst focused on addressing global challenges with scientific solutions. Integrated Concentration in Science (iCons) is an overarching concentration program that supplements the curricula provided within each student's chosen major. iCons is a platform for students to perform student-led research in interdisciplinary collaborative teams. With a schedule of one course per year over four years, the cohort of students move through case studies, analysis of real-world problems, development of potential solutions, integrative communication, laboratory practice, and capstone research projects. In this presentation, a track emphasizing renewable energy science is used to illustrate the iCons pedagogical methods. This includes discussion of a third-year laboratory course in renewable energy that is educationally scaffolded: beginning with a boot camp in laboratory techniques and culminating with student-designed research projects. Among other objectives, this course emphasizes the practice of using reflection and redesign, as a means of generating better solutions and embedding learning for the long term.

Tuominen, Mark



Anti-human IG and B lymphocytes reconstitute the proliferative response to Con A of T lymphocytes depleted of accessory cells  

SciTech Connect

The requirements for the induction of proliferation of human peripheral blood mononuclear cells (PBM) by low concentrations of Concanavalin A (Con A) were studied using /sup 3/H-thymidine incorporation to assay DNA synthesis. Removal of plastic-adherent cells from PBM reduced the proliferative response of lymphocytes to Con A by 80%. Passage of these cells over nylon wool columns totally eliminated their response to Con A. Addition of adherent monocytes or rabbit anti-human IgG conjugated to polyacrylamide beads (anti-IgG beads) to the non-adherent lymphocyte population reconstituted the proliferative response. The lymphoblasts activated in these cultures were more than 90% T11 positive. Anti-IgG beads did not activate lymphocyte proliferation in the absence of Con A. The response of non-adherent lymphocytes to Con A could also be reconstituted by unconjugated rabbit anti-human IgG antiserium. Purified T cells could only be activated by anti-IgG beads and low concentrations of Con A in the presence of irradiated B cells. These results suggest that /sup 3/H-thymidine incorporation by T cells induced by anti-IgG beads and a low concentration of Con A depends on the interaction of anti-IgG and B cells. The authors suggest that B cell produce growth factors for T cells after interacting with anti-IgG.

Tsuda, T.; Kim, Y.T.; Schwab, R.; Siskind, G.W.; Weksler, M.E.



Nanoparticulas basadas en complejos de Fe(II) con transicion de espin: sintesis, caracterizacion y aplicaciones en electronica molecular  

NASA Astrophysics Data System (ADS)

Esta tesis doctoral esta organizada en 5 capitulos y esta destinada al estudio de sistemas de Fe (II) que presentan el fenomeno de la transicion de espin a escala nanometrica. El capitulo 1 contiene una introduccion general sobre materiales moleculares multifuncionales, destacando aquellos ejemplos mas importantes. Por otro lado, se explicara el fenomeno de la transicion de espin, tratando aspectos conceptuales, los antecedentes mas importantes y la situacion actual. En el capitulo 2 se describen los diferentes procesos existentes para la obtencion de diferentes tipos de nanoparticulas. Ademas, se presenta la sintesis y caracterizacion de nanoparticulas del polimero de coordinacion unidimensional [Fe(Htrz)2(trz)]BF4, obtenidas mediante el metodo de micelas inversas. Estas nanoparticulas, con una estrecha distribucion de tamanos centrada alrededor de los 11 nm, presentan una transicion de espin muy abrupta, con un ancho ciclo de histeresis termica de unos 40K. En el capitulo 3 se describe el proceso de modificacion del tamano de las nanoparticulas descritas en el capitulo anterior, llevado a cabo variando la proporcion de surfactante/H2O en el medio. Ademas, con el objetivo de modificar las propiedades magneticas de las nanoparticulas obtenidas en el capitulo 2, se lleva a cabo la sintesis de nanoparticulas de polimeros de la misma familia del [Fe(Htrz)2(trz)]BF4. En concreto se sintetizaron 3 nuevos tipos de nanoparticulas basadas en el polimero [Fe(Htrz)1-x(NH2trz)x](ClO4)2, siendo x = 0.05, 0.15 y 0.3, en cada caso. Estas nanoparticulas siguen presentando una estrecha distribucion de tamanos y una transicion de espin muy abrupta y con un ancho ciclo de histeresis. Ademas, se observa que este ciclo se desplaza a temperaturas mas proximas a la temperatura ambiente a medida que se aumenta el porcentaje de 4-amino-1, 2, 4- triazol en la muestra. Pero al mismo tiempo se produce una disminucion de la anchura de este ciclo. Por ultimo, en este capitulo se presenta la sintesis de otro nuevo tipo de nanoparticulas, obtenidas a partir de otro polimero de la misma familia, el [FeO8ZnO2(Htrz)3](BF4). Estas nanoparticulas se sintetizaron con el objetivo de estudiar el efecto de la dilucion del metal en la muestra. Como resultado se obtuvieron nanoparticulas que tambien presentan una estrecha distribucion de tamanos pero en este caso la transicion de espin no es tan abrupta como en los casos anteriores. Aunque sigue presentando un ciclo de histeresis termica bastante ancho y a temperaturas proximas a la temperatura ambiente. En el capitulo 4 se describiran las estrategias que se han seguido para mejorar la estabilidad y afinidad sobre diferentes sustratos de las nanoparticulas sintetizadas en el capitulo 2. Tambien se hablara de los intentos realizados parar depositarlas en superficies y embeberlas en diferentes matrices organicas e inorganicas. En el capitulo 5 presentaremos la obtencion de un interruptor molecular realizado poniendo en contacto nanoparticulas individuales sintetizadas en el capitulo 2, con unos electrodos separados varios nanometros. Este dispositivo exhibe "switching" y efecto memoria a temperaturas proximas a la temperatura ambiente como consecuencia de la biestabilidad intrinseca de las nanoparticulas. Ademas demostraremos que el estado magnetico de estas nanoparticulas puede ser controlado electricamente, ya que la transicion de espin en este nanodispositivo molecular puede ser inducida simplemente aplicando un voltaje, lo que puede ser de gran interes para la electronica molecular.

Monrabal Capilla, Maria


To be presented at the Fourth International Workshop on Virtual Rehabilitation, Catalina Island, CA, September 2005. Usability of the Remote Console (ReCon) for Virtual Reality  

E-print Network

, September 2005. Usability of the Remote Console (ReCon) for Virtual Reality Telerehabilitation: Formative reality rehabilitation exercises. It provides the therapists with visual representations of the patients. Keywords virtual reality, telerehabilitation, physical therapy, formative evaluation, usability engineering

New Jersey, University of Medicine and Dentistry of


Facolt proponente: Facolt di Economia dell'Universit di Genova in collaborazione con: Aon, AXA Corporate Solutions, Banchero Costa Insurance Broker, Cambiaso Risso  

E-print Network

Facoltà proponente: Facoltà di Economia dell'Università di Genova in collaborazione con: Aon, AXA specialistici in Economia, Giurisprudenza, Scienze politiche. La partecipazione al corso può essere gratuita

Genova, Università degli Studi di


Facolt proponente: Facolt di Economia dell'Universit di Genova in collaborazione con: Centro Sportivo Paladonbosco, ANIF -EuroWellness Associazione Nazionale Impianti  

E-print Network

Facoltà proponente: Facoltà di Economia dell'Università di Genova in collaborazione con: Centro'innovazione nella gestione delle problematiche connesse. Laureati in Architettura, Economia, Giurisprudenza

Genova, Università degli Studi di


Presentaci?n del estudio "Links" de hombres que tienes sexo con hombres en Buenos Aires, Argentina  

PubMed Central

Resumen Estudios previos en Buenos Aires reportaron altas prevalencias de HIV entre HSH, con valores que oscilan entre 9 y 14% durante casi 10 años de continuo testeo. El objetivo principal de este estudio fue la evaluación de factores relacionados al comportamiento de alto riesgo para transmisión del HIV entre HSH entre los que se incluyen el conocimiento y factores emocionales, socioculturales y ambientales. Por otro lado se realizó la estimación de prevalencia e incidencia de HIV utilizando RDS (Respondent Driven Sampling), así como la presencia de otras infecciones de transmisión sexual. Por último se evaluaron los hábitos de testeo para HIV indagando que factores facilitan o impiden su realización. El estudio constó de dos fases, en primer lugar una fase cualitativa y posteriormente una fase cuantitativa con una duración total de 4 años y medio. Durante la fase cualitativa se realizaron 44 entrevistas individuales en profundidad, 8 grupos focales y 10 observaciones etnográficas (hoteles, baños públicos (“teteras”), cines pornográficos, fiestas privadas, dark rooms y discotecas). Durante la fase cuantitativa del estudio se realizó el reclutamiento de 500 participantes que provinieron de la Ciudad Autónoma de Buenos Aires, así como del Gran Buenos Aires. El reclutamiento se comenzó con 16 participantes llamados semillas. Se realizó el diagnóstico de infección por HIV, hepatitis B y C (HBV y HCV), Treponema pallidum, Virus Papiloma Humano (HPV) y Chlamidias. La colaboración establecida entre los grupos de trabajo enfocados en áreas diversas posibilitó el abordaje conjunto de nuevas estrategias de investigación antes no exploradas en nuestro país. Los resultados más relevantes de esta investigación serán progresivamente publicados en sucesivos números de Actualizaciones en SIDA.

Carballo-Dieguez, Alex; Avila, Maria M; Balan, Ivan C.; Marone, Ruben; Pando, Maria A.; Barreda, Victoria



Una cinta transportadora de longitud l se mueve con velocidad v respecto al suelo. Por su extremo derecho se introduce un bloque de masa m que se mover en contra de la cinta  

E-print Network

Problema 2 Una cinta transportadora de longitud l se mueve con velocidad v respecto al suelo. Por). Determine la velocidad vo (respecto al suelo) con la cual es necesario impulsar el bloque contra el, y que ahí se detenga respecto al suelo. En tal punto, con el bloque en reposo respecto al suelo

Chang, Mark J. L.



Microsoft Academic Search

sos, con predominio en varones (OR=1.46; IC=1.12-1.91; p=0.03). Actividad física semanal: 3.9 ± 2.9 hs. mayor en varones (p<0.001). Horas de sedentarismo: 3.2 ± 1.9. Antecedentes: obesidad materna 282 (13.3%), paterna 311 (14.7%), en ambos 116 (6.6%). Consumo regular de comidas grasas: 1711 (80.9%). PAS: 107.8 ± 13.6; PAD: 66.9 ± 11.5; PAM: 80.5 ± 10.1. Hipertensos 64 (3%) a




Metal ion determinants of conantokin dimerization as revealed in the X-ray crystallographic structure of the Cd 2+ \\/Mg 2+ –conT[K7?] complex  

Microsoft Academic Search

Predatory sea snails from the Conus family produce a variety of venomous small helical peptides called conantokins that are rich in ?-carboxyglutamic acid (Gla)\\u000a residues. As potent and selective antagonists of the N-methyl-d-aspartate receptor, these peptides are potential therapeutic agents for a variety of neurological conditions. The two most\\u000a studied members of this family of peptides are con-G and con-T.

Sara E. Cnudde; Mary Prorok; Francis J. Castellino; James H. Geiger



Geometria III, Problemas 6 Segundo semestre, 2009/10. (R) es el plano proyectivo con la estructura diferencial estudiada en clase.  

E-print Network

estructura diferencial estudiada en clase. Sea f : P2 (R) R definida como f[x, y, z] = x2 x2 + y2 + z2 admite una estructura de variedad de dimensi´on 3 con un atlas de una sola carta (M, ) donde (C) = (x, y. Tras identificarlo con R4 , M recibe una estructura diferencial a partir de la estructura diferencial

Guijarro, Luis


Analysis of cancer risk and BRCA1 and BRCA2 mutation prevalence in the kConFab familial breast cancer resource  

Microsoft Academic Search

INTRODUCTION: The Kathleen Cuningham Foundation Consortium for Research into Familial Breast Cancer (kConFab) is a multidisciplinary, collaborative framework for the investigation of familial breast cancer. Based in Australia, the primary aim of kConFab is to facilitate high-quality research by amassing a large and comprehensive resource of epidemiological and clinical data with biospecimens from individuals at high risk of breast and\\/or

Graham J Mann; Heather Thorne; Rosemary L Balleine; Phyllis N Butow; Christine L Clarke; Edward Edkins; Gerda M Evans; Sián Fereday; Eric Haan; Michael Gattas; Graham G Giles; Jack Goldblatt; John L Hopper; Judy Kirk; Jennifer A Leary; Geoffrey Lindeman; Eveline Niedermayr; Kelly-Anne Phillips; Sandra Picken; Gulietta M Pupo; Christobel Saunders; Clare L Scott; Amanda B Spurdle; Graeme Suthers; Kathy Tucker; Georgia Chenevix-Trench



Modelo de accesibilidad de conceptos matematicos aplicados en el curso de Astronomia Descriptiva para estudiantes con impedimentos visuales en la UPR  

NASA Astrophysics Data System (ADS)

Este estudio utiliza metodologia de investigacion cualitativa, con el proposito de describir, analizar y evaluar los procesos de diseno y desarrollo de un modelo de accesibilidad que consiste en estrategias de ensenanza de las matematicas para estudiantes con impedimentos visuales matriculados en el curso de Astronomia Descriptiva en la UPR. Se utilizaron las siguientes estrategias para recopilar la informacion, 1) reflexiones de la investigadora en el proceso de diseno y desarrollo de las lecciones adaptadas, que se registraron en un diario reflexivo. 2) entrevista semiestructurada luego de haber trabajado las lecciones de aprendizaje adaptadas con los participantes. 3) observaciones y notas de la investigadora del trabajo de los participantes. Para obtener la informacion de los participantes se obtuvo los permisos institucionales necesarios; se seleccionaron los participantes y se validaron los instrumentos; se realizo el desarrollo de las lecciones adaptadas con los participantes; y finalmente, se analizo la informacion obtenida. El diseno de las lecciones de aprendizaje adaptadas se hizo siguiendo las recomendaciones curriculares de los temas de matematicas aplicados en el curso de Astronomia Descriptiva realizado por la investigadora durante su semestre de internado. El testimonio de las voces de los participantes se obtuvo del proceso de desarrollo de las lecciones de aprendizaje adaptadas de temas seleccionados de conceptos matematicos requeridos en el curso de Astronomia Descriptiva y de la entrevista semiestructurada con los participantes, luego de haber trabajado las lecciones de aprendizaje. Para el desarrollo de las lecciones de aprendizaje, se utilizaron materiales tactiles adaptados, materiales tactiles disenados y materiales disponibles comercialmente. Los textos de las lecciones se imprimieron en tinta y en Braille. Se exhorta a disenar y desarrollar estrategias de ensenanza accesibles, considerando como recursos para evaluar su efectividad a personas con impedimentos visuales. El utilizar estrategias de aprendizaje accesibles de acuerdo a las necesidades individuales de los estudiantes, contribuye para que los estudiantes con impedimentos visuales descubran, exploren, investiguen y formulen sus propias conclusiones durante su proceso de aprendizaje.

Isidro Villamizar, Gloria Maria



NASA Astrophysics Data System (ADS)

In this paper, the effect of the flood hazard map distributed to the residents who experienced flood disasters recently and an effective method for improving consciousness of flood di saster prevention are discussed. The questionnaire surveys were conducted on the residents living in the middle basin of the Nishiki River, Iwakuni city, Yamaguchi Prefecture, before and after the distribution of the hazard map. It is found from this investigation that "knowledge", "att achment", and "crisis", are the main factors in the psychological process related to the flood prevention behavior. The effect of the distribution of the hazard map is judged from the probability of the flood prevention behavior. In addition, it is also found that "knowledge", "flood experiment of T0514", "crisis", "eff ectiveness", "load", and "easy reading of the hazard map", are keys to improve the cons ciousness of flood di saster prevention.

Asai, Koji; Koga, Syota; Sakakibara, Hiroyuki


Intraspecific alkaloid variation in ladybird eggs and its effects on con- and hetero-specific intraguild predators.  


Egg predation and cannibalism are common phenomena in predatory ladybirds despite the presence of defensive alkaloids. Consumption of heterospecific eggs negatively affects survivorship and development; however, intraspecific variation in quantities of alkaloids and post-ingestion responses to con- and hetero-specific alkaloids, are not well understood. We examined variation in the quantity of alkaloids in eggs of Harmonia axyridis (Pallas), Coccinella septempunctata L., and Hippodamia convergens (Guérin) using gas chromatography-mass spectrometry, and show a link between heterospecific alkaloids and their toxicity and/or costs by feeding high and low alkaloid eggs to first instar H. axyridis and C. septempunctata. The repeatability of alkaloid measurements in eggs in an egg cluster was high; however, the amount of alkaloids varied significantly between egg clutches within and among females. This variation affected egg consumption by C. septempunctata when fed H. axyridis eggs. Harmonia axyridis accumulated their own alkaloid by cannibalism and synthesized it de novo, but C. septempunctata lost some portion of the consumed conspecific alkaloids. Both species lost most of the consumed heterospecific alkaloids, but C. septempunctata died within 3 days. Most H. axyridis survived to the second instar, but C. septempunctata alkaloids led to a significant reduction in weight gain compared to an aphid control. In addition, ingestion of high alkaloid C. septempunctata extended development of H. axyridis compared to the aphid control or conspecific eggs. Harmonia axyridis had greater abilities to process ingested con- and hetero-specific alkaloids compared with C. septempunctata, which may, in part, explain their interspecific interactions in nature. PMID:20049478

Kajita, Yukie; Obrycki, J J; Sloggett, J J; Haynes, K F



Lectin from Canavalia brasiliensis (ConBr) protects hippocampal slices against glutamate neurotoxicity in a manner dependent of PI3K/Akt pathway.  


The excitotoxicity induced by excessive activation of the glutamatergic neurotransmission pathway is involved in several neuropathologies. In this sense, molecules that prevent the release of glutamate or the excessive activation of its receptors can be useful in preventing the neuronal cell death observed in these diseases. Lectins are proteins capable of reversible binding to the carbohydrates in glycoconjugates, and some have been used in the study and purification of glutamate receptors. ConBr is a mannose/glucose-binding lectin purified from Canavalia brasiliensis seeds. In the present study, we aimed to evaluate the neuroprotective activity of ConBr against glutamate-induced excitotoxicity. Hippocampal slices were isolated from adult male mice and incubated for 6h in Krebs saline/DMEM buffer alone (control), in the presence of glutamate or glutamate plus ConBr. The phosphorylation of Akt and mitogen activated protein kinases (MAPKs) such as ERK1/2, p38(MAPK) and JNK1/2/3 was evaluated with western blotting. The results indicate that glutamate provoked a reduction in the hippocampal slice viability (-25%), diminished the phosphorylation of Akt and augmented p38(MAPK) and ERK1 phosphorylation. No changes were observed in the phosphorylation of JNK1/2/3 or ERK2. Notably, ConBr, through a mechanism dependent on carbohydrate interaction, prevented the reduction of cell viability and Akt phosphorylation induced by glutamate. Furthermore, in the presence of the PI3K inhibitor LY294002, ConBr was unable to reverse glutamate neurotoxicity. Taken together, our data suggest that the neuroprotective effect of ConBr against glutamate neurotoxicity requires oligosaccharide interaction and is dependent on the PI3K/Akt pathway. PMID:23454192

Jacques, Amanda V; Rieger, Débora K; Maestri, Mariana; Lopes, Mark W; Peres, Tanara V; Gonçalves, Filipe M; Pedro, Daniela Z; Tasca, Carla I; López, Manuela G; Egea, Javier; Nascimento, Kyria S; Cavada, Benildo S; Leal, Rodrigo B



Selenium Promotes T-Cell Response to TCR-Stimulation and ConA, but Not PHA in Primary Porcine Splenocytes  

PubMed Central

There is controversy in the literature over whether the selenium (Se) influences cellular immune responses, and the mechanisms possibly underlying these effects are unclear. In this study, the effects of Se on T-cell proliferation and IL-2 production were studied in primary porcine splenocytes. Splenocytes were treated with different mitogens in the presence of 0.5–4 µmol/L sodium selenite. Se significantly promoted T-cell receptor (TCR) or concanavalin A (ConA)-induced T-cell proliferation and IL-2 production but failed to regulate T-cell response to phytohemagglutinin (PHA). In addition, Se significantly increased the levels of cytosolic glutathione peroxidase (GPx1) and thioredoxin reductase 1 (TR1) mRNA, the activity of GPx1 and the concentration of reduced glutathione (GSH) in the unstimulated, or activated splenocytes. These results indicated that Se improved the redox status in all splenocytes, including unstimulated, TCR, ConA and PHA -stimulated, but only TCR and ConA-induced T-cell activation was affected by the redox status. N-acetylcysteine (NAC), a pharmacological antioxidant, increased T-cell proliferation and IL-2 production by TCR and ConA stimulated splenocytes but had no effect on the response to PHA in primary porcine splenocytes confirming that PHA-induced T-cell activation is insensitive to the redox status. We conclude that Se promotes GPx1 and TR1 expression and increases antioxidative capacity in porcine splenocytes, which enhances TCR or ConA -induced T-cell activation but not PHA-induced T-cell activation. The different susceptibilities to Se between the TCR, ConA and PHA -induced T-cell activation may help to explain the controversy in the literature over whether or not Se boosts immune responses. PMID:22530011

Ren, Fei; Chen, Xingxiang; Hesketh, John; Gan, Fang; Huang, Kehe



Inversor Resonante de Tres Elementos L-LC con Caracteristica Cortocircuitable para Aplicaciones de Calentamiento por Induccion  

NASA Astrophysics Data System (ADS)

Los generadores de calentamiento por induccion son puentes inversores con carga resonante, cuya mision es basicamente crear una corriente sinusoidal de gran amplitud sobre la "bobina de caldeo", que forma parte del tanque resonante. En el interior de esta bobina se introduce la pieza que se desea calentar. EI campo magnetico creado induce corrientes superficiales (corrientes de Foucault) sobre la pieza, que producen su calentamiento. Los tanques resonantes (tambien llamados osciladores) utilizados en la actualidad son el resonante serie y el resonante paralelo. Aunque ya desde hace algun tiempo se vienen construyendo generadores de alta potencia basados en estos dos osciladores, el exito nunca ha. sido completo en ninguno de los dos casos. Tal y como se explica en la introduccion de esta memoria, los puentes inversores utilizados deben operar sobre una carga inductiva (corriente retrasada) para evitar el fenomeno de la recuperacion inversa de sus diodos y la consiguiente ruptura de los transistores. De la restriccion topologica anterior se deduce que el generador paralelo debe conmutar a frecuencias inferiores a la resonancia, y el serie a frecuencias superiores. A esta restriccion topologica hay que unir otra que es exclusiva del calentamiento por induccion: La corriente por la bobina de caldeo debe ser sinusoidal. De no ser asi, resultaria imposible disponer toda la potencia de calentamiento sobre la pieza en el espesor requerido por la aplicacion. Como consecuencia, los inversores no pueden operar por debajo de la frecuencia de resonancia del oscilador, pues en ese caso se amplifican los armonicos de orden superior de la tension/corriente de entrada situados sobre la resonancia, con la consiguiente distorsion de la corriente de salida. La conjuncion de las dos restricciones anteriores obligan al inversor paralelo a funcionar a la frecuencia de resonancia del oscilador. Esto imposibilita un control por variacion de frecuencia, regulandose la potencia desde la seccion de entrada mediante un mayor o menor aporte de corriente al puente. Como consecuencia, la seccion de entrada del paralelo, ya de por si mas voluminosa que lao del serie por el uso de grandes componentes magneticos (bobinas de filtro o de "alisamiento"), result a tambien mas complicada y costosa debido a la necesidad de ser implementada mediante rectificador controlado. Ademas, la regulacion que ofrece el rectificador es pobre, dada su baja frecuencia de conmutacion. En cambio, el circuito serie puede funcionar por encima de la resonancia manteniendo una secuencia de conmutacion sin riesgos de recuperacion inversa y con una corriente de salida practicamente sinusoidal, lo que permite un control de la potencia por variacion de frecuencia. Puesto que la tarea de regulacion se realiza desde el puente inversor, la regulacion resulta mucho mas eficaz y la seccion de entrada se puede implementar mediante un simple rectificador no controlado y un condensador de filtro. (Abstract shortened by UMI.).

Espi Huerta, Jose Miguel



Microsoft Academic Search

La selección recurrente para aptitud combinatoria en cultivos autógamos (SRAC), aunque exitosa, enfrenta dificultades para ha- cer las cruzas y para obtener suficiente semilla de éstas. Además, las derivaciones de la respuesta a la SRAC (R) basadas en el mode- lo de dos alelos pueden no ser adecuadas si la población se formó con más de dos progenitores. El objetivo

Jaime Sahagún-Castellanos; Autónoma Chapingo



Synthesis, growth, structural, spectral, thermal, chemical etching, linear and nonlinear optical and mechanical studies of an organic single crystal 4-chloro 4-nitrostilbene (CONS): A potential NLO material  

NASA Astrophysics Data System (ADS)

4-Chloro 4-nitrostilbene (CONS) a new organic nonlinear optical material has been synthesized. Employing slow evaporation method, good optical quality single crystals (dimensions up to 6 × 2 × 3 mm3) have been grown using ethyl methyl ketone (EMK) as a solvent. The grown crystals have been subjected to various characterizations such as single crystal X-ray diffraction, powder XRD, Fourier Transform Infrared spectroscopy (FTIR), proton NMR, solid UV absorption, SHG studies. Single crystal X-ray diffraction reveals that the crystal system belongs to monoclinic with noncentrosymmetric space group P21. The UV-Vis absorption spectrum has been recorded and found that the cut off wavelength is 380 nm. Functional groups and the structure of the title compound have been confirmed by FTIR and 1H NMR spectroscopic analyses respectively. Molecular mass of the CONS confirmed by the high resolution mass spectral analysis .The thermal behavior of the grown crystal has been studied by TG/DTA analysis and it shows the melting point is at 188.66 °C. Dislocations and growth pattern present in the grown crystal revealed by the etching study. The mechanical strength of the CONS crystal has been studied by Vicker's hardness measurement. The SHG efficiency of the grown crystal has been determined by Kurtz and Perry powder test which revealed that the CONS crystal (327 mV) has 15 times greater efficiency than that of KDP (21.7 mV).

Dinakaran, Paul M.; Kalainathan, S.




E-print Network

INTERNATIONAL SERIES IN PURE AND APPLIED PHYSICS LEO N A R D 1. S CHI F F, CON S U L TIN G E D ITO R Allis and Herlin Thermodynamics and Statistical Mechanics Becker Introduction to Theoretical Mechanics Clark Applied X-rays Collin Field Theory of Guided Waves Evans The Atomic Nucleus Finkelnburg

Allen, Jont


¿Es segura la combinacion de IECA o ARA II con espironolactona? Is the combination of ACE inhibitors and ASA with spirolactone safe?  

Microsoft Academic Search

Resumen Objetivos: determinar si en pacientes evaluados por hiperpotasemia en un servicio de nefrología la combinación IECA (inhibidores de enzima convertidora de angiotensina II) o ARA II (antagonistas del receptor de angiotensina II) con espironolactona estaba presente y qué consecuencias tuvo sobre el grupo de pacientes identificados. Diseño: estudio de tipo observacional, descriptivo retrospectivo y prospectivo. Lugar: unidad renal STR




Nominativo Sede seggioSeggio Elezioni R.S.U. -5/7 marzo 2012 -elenco del personale con seggio assegnato  

E-print Network

Nominativo Sede seggioSeggio Elezioni R.S.U. - 5/7 marzo 2012 - elenco del personale con seggio - C.U.2 ERCOLI Carla AULA RSU PIANO ­ 3, OSPEDALE SANT'ANDREA - VIA DI GROTTAROSSA, 103513 ERMILI MINERALOGIA - C.U.2 FABRIZIO Luigi AULA RSU PIANO ­ 3, OSPEDALE SANT'ANDREA - VIA DI GROTTAROSSA, 103513

Guidoni, Leonardo


474 The american biology Teacher volume 73, no. 8, ocTober 2011 The accumulation of plastic in the oceans is an ever-growing environmental con-  

E-print Network

of plastic pollution. They can be modified to be appro- priate for grades 6­10. Oikonos Ecosystem Knowledge. The plastic-pollution curriculum described here was further developed and modified by CAMEOS, a National of plastic in the oceans is an ever-growing environmental con- cern. Plastic debris is a choking

Schladow, S. Geoffrey


ConSoil 2005 -Abstract form Title of abstract Alcohol Flushing: Parameter Estimation for a cost efficient in-situ remediation  

E-print Network

ConSoil 2005 - Abstract form Title of abstract Alcohol Flushing: Parameter Estimation for a cost efficient in-situ remediation of an aquifer contaminated with DNAPL Author(s) + organisation, Phone +49 - 711 / 685 4602 Fax +49 - 711 / 685 7020 Topics: Alcohol flushing, in-situ remediation

Cirpka, Olaf Arie



Microsoft Academic Search

Desde hace más de dos décadas se viene planteando en disímiles escenarios que el desarrollo sostenible es la única alternativa presente y viable a la salvaguardia de la humanidad, lo cual constituye una cuestión de ética con la naturaleza y el ser humano, donde la responsabilidad y la conciencia social juegan un rol fundamental para contribuir a una gestión racional

Tania Vargas Fernández; Deysi Alfonso Porraspita; Meibys Díaz Labrador



EXCELLENTIA CoLumbIA ENgINEErINg 61 any sports-related injuries involve soft tissues such as ligaments, which con-  

E-print Network

HEALTH EXCELLENTIA CoLumbIA ENgINEErINg 61 HEALTH M any sports-related injuries involve soft tissues such as ligaments, which con- nect bone with bone, and tendons, which join muscle to bone. Each on engineering the interface that connects soft tissue to bone. While tissue engineering has traditionally

Hone, James


2.4ContaminantTransportandManagement(CONTAM) The ConTAM research area focuses on developing technology to observe and manage mass and energy  

E-print Network

2.4ContaminantTransportandManagement(CONTAM) The ConTAM research area focuses on developing:on domain, and high resolu:on river data are being modeled in terms of primaryproduc measurements, remote sensingobserva:ons,physically based process models, etc.) and has been

California at Los Angeles, University of


Pure Appl. Chem., Vol. 82, No. 12, pp. 22472279, 2010. doi:10.1351/PAC-CON-10-09-04  

E-print Network

2247 Pure Appl. Chem., Vol. 82, No. 12, pp. 2247­2279, 2010. doi:10.1351/PAC-CON-10-09-04 © 2010 to the trans form once the UV source is removed. Although this thermal re-isomerization is slow, *Pure Appl

Martin, Jan M.L.


In many real-world situations, short-term rewards con-flict with long-term benefits. Consider the case of global  

E-print Network

the case of global warming, for which a group's difficulty in changing its behavior reflects a considerableIn many real-world situations, short-term rewards con- flict with long-term benefits. Consider in real-world situations involves not only weighing the costs and benefits of par- ticular actions

Love, Bradley C.


Geometria III, Problemas 5 Primer semestre, 2010/11. (R) es el plano proyectivo con la estructura diferencial estudiada en clase.  

E-print Network

estructura diferencial estudiada en clase. Si : (-/2, /2) P2 (R) es la curva cuyo punto (t) corresponde conjunto de todas las circunferencias del plano R2 . Demuestre que M admite una estructura de variedad de dimensi´on 3 con un atlas de una sola carta. Para la estructura diferencial encontrada, conteste a las

Guijarro, Luis


Geometria III, Problemas 5 Segundo semestre, 2009/10. (R) es el plano proyectivo con la estructura diferencial estudiada en clase.  

E-print Network

estructura diferencial estudiada en clase. Si : (-/2, /2) P2 (R) es la curva cuyo punto (t) corresponde conjunto de todas las circunferencias del plano R2 . Demuestre que M admite una estructura de variedad de dimensi´on 3 con un atlas de una sola carta. Para la estructura diferencial encontrada, conteste a las

Guijarro, Luis


El papado de Pablo IV (1555-1559), las relaciones con Venecia y Espaa y el cambio de orientacin poltico-religiosa de las lites eclesisticas italianas  

E-print Network

el núcleo del entourage del joven emperador (tales el gran canciller Mercurino Gattinara y el 5190, Lyon / Università di Milano Presentamos en este trabajo las principales conclusiones de nuestra tesis, "Il papato di Paolo IV nella crisi politico-religiosa del Cinquecento: le relazioni con la

Paris-Sud XI, Université de


Getting the Most from Your CD-ROM Dollars: The CD-ROM Bundle [and] The Pros and Cons of CD-ROM Bundling.  

ERIC Educational Resources Information Center

Discusses and reviews CD-ROM bundles--i.e., hardware, software and CD-ROM kits--including their features, specifications, drawbacks, and prices. Recommends buying through mail order for the best selection and price. The pros and cons of bundling as a marketing strategy are discussed and a list of vendors is provided. (EA)

Sarjeant, Eric W.; O'Connor, Mary Ann



arXiv:submit/0083985[cond-mat.supr-con]29Jul2010 Metastability in a nano-bridge based hysteretic DC-SQUID embedded in  

E-print Network

arXiv:submit/0083985[cond-mat.supr-con]29Jul2010 Metastability in a nano-bridge based hysteretic DC-SQUID study the metastable response of a highly hysteretic DC-SQUID made of a Niobium loop interrupted by two nano-bridges. We excite the SQUID with an alternating current and with direct magnetic flux, and find

Buks, Eyal


Carlo Beenakker, Leiden University Graphene is a mono-atomic layer of carbon atoms, arranged in a honeycomb la ice. Con-  

E-print Network

, arranged in a honeycomb la ice. Con- duction electrons move in the x- plane of the layer, with velocity", and is a unique feature of graphene. We introduce a potential barrier U (x) (see gure). An electron moves = 106 m/s that is inde- pendent of their energy E. [1] Explain why the conduction electrons in graphene

Galis, Frietson


Uso de las máquinas de pivote central en el riego con aguas residuales Use of the center pivot machine in the irrigation with wastewaters  

Microsoft Academic Search

RESUMEN. Es una realidad mundial, actual, que el agua potable es cada día más escasa para todos los usos en las actividades diarias de la población. La agricultura es el mayor consumidor de agua, con marcado incremento en los países en vías de desarrollo donde a su vez se requiere de una mayor producción de alimentos. En áreas urbanas y

Candelario Alemán G



Synthesis, growth, structural, spectral, thermal, chemical etching, linear and nonlinear optical and mechanical studies of an organic single crystal 4-chloro 4-nitrostilbene (CONS): a potential NLO material.  


4-Chloro 4-nitrostilbene (CONS) a new organic nonlinear optical material has been synthesized. Employing slow evaporation method, good optical quality single crystals (dimensions up to 6×2×3 mm(3)) have been grown using ethyl methyl ketone (EMK) as a solvent. The grown crystals have been subjected to various characterizations such as single crystal X-ray diffraction, powder XRD, Fourier Transform Infrared spectroscopy (FTIR), proton NMR, solid UV absorption, SHG studies. Single crystal X-ray diffraction reveals that the crystal system belongs to monoclinic with noncentrosymmetric space group P21. The UV-Vis absorption spectrum has been recorded and found that the cut off wavelength is 380 nm. Functional groups and the structure of the title compound have been confirmed by FTIR and (1)H NMR spectroscopic analyses respectively. Molecular mass of the CONS confirmed by the high resolution mass spectral analysis .The thermal behavior of the grown crystal has been studied by TG/DTA analysis and it shows the melting point is at 188.66 °C. Dislocations and growth pattern present in the grown crystal revealed by the etching study. The mechanical strength of the CONS crystal has been studied by Vicker's hardness measurement. The SHG efficiency of the grown crystal has been determined by Kurtz and Perry powder test which revealed that the CONS crystal (327 mV) has 15 times greater efficiency than that of KDP (21.7 mV). PMID:23624038

Dinakaran, Paul M; Kalainathan, S



Departamento de Disciplinas Econmicas y Financieras El Departamento de Disciplinas Econmicas y Financieras, con sede en la Facultad de Derecho de la Universidad  

E-print Network

Financieras, con sede en la Facultad de Derecho de la Universidad de Alicante, est� compuesto por el �rea de conocimiento de Derecho Financiero y Tributario que centra su actividad en las facultades de Derecho, Ciencias titulaciones: Estudios de 1er y 2� Ciclo (a extinguir) Licenciatura en Derecho. Licenciatura Derecho-ADE (DADE

Escolano, Francisco


AVISO EN CONTRA DE ACTOS DISCRIMINATORIOS De conformidad con la Ley de Derechos Humanos del Distrito de Columbia (D.C.) de 1977, segn enmendada,  

E-print Network

AVISO EN CONTRA DE ACTOS DISCRIMINATORIOS De conformidad con la Ley de Derechos Humanos del a medidas disciplinarias. La Ley de Derechos Humanos del Distrito de Columbia (D.C.), Sección 2-1402.31(a discriminar: "Negarle a una persona, de forma directa o indirecta, el derecho a disfrutar a plenitud y

Weaver, Harold A. "Hal"


Analysis of cancer risk and BRCA1 and BRCA2 mutation prevalence in the kConFab familial breast cancer resource  

PubMed Central

Introduction The Kathleen Cuningham Foundation Consortium for Research into Familial Breast Cancer (kConFab) is a multidisciplinary, collaborative framework for the investigation of familial breast cancer. Based in Australia, the primary aim of kConFab is to facilitate high-quality research by amassing a large and comprehensive resource of epidemiological and clinical data with biospecimens from individuals at high risk of breast and/or ovarian cancer, and from their close relatives. Methods Epidemiological, family history and lifestyle data, as well as biospecimens, are collected from multiple-case breast cancer families ascertained through family cancer clinics in Australia and New Zealand. We used the Tyrer-Cuzick algorithms to assess the prospective risk of breast cancer in women in the kConFab cohort who were unaffected with breast cancer at the time of enrolment in the study. Results Of kConFab's first 822 families, 518 families had multiple cases of female breast cancer alone, 239 had cases of female breast and ovarian cancer, 37 had cases of female and male breast cancer, and 14 had both ovarian cancer as well as male and female breast cancer. Data are currently held for 11,422 people and germline DNAs for 7,389. Among the 812 families with at least one germline sample collected, the mean number of germline DNA samples collected per family is nine. Of the 747 families that have undergone some form of mutation screening, 229 (31%) carry a pathogenic or splice-site mutation in BRCA1 or BRCA2. Germline DNAs and data are stored from 773 proven carriers of BRCA1 or BRCA1 mutations. kConFab's fresh tissue bank includes 253 specimens of breast or ovarian tissue – both normal and malignant – including 126 from carriers of BRCA1 or BRCA2 mutations. Conclusion These kConFab resources are available to researchers anywhere in the world, who may apply to kConFab for biospecimens and data for use in ethically approved, peer-reviewed projects. A high calculated risk from the Tyrer-Cuzick algorithms correlated closely with the subsequent occurrence of breast cancer in BRCA1 and BRCA2 mutation positive families, but this was less evident in families in which no pathogenic BRCA1 or BRCA2 mutation has been detected. PMID:16507150

Mann, Graham J; Thorne, Heather; Balleine, Rosemary L; Butow, Phyllis N; Clarke, Christine L; Edkins, Edward; Evans, Gerda M; Fereday, Sián; Haan, Eric; Gattas, Michael; Giles, Graham G; Goldblatt, Jack; Hopper, John L; Kirk, Judy; Leary, Jennifer A; Lindeman, Geoffrey; Niedermayr, Eveline; Phillips, Kelly-Anne; Picken, Sandra; Pupo, Gulietta M; Saunders, Christobel; Scott, Clare L; Spurdle, Amanda B; Suthers, Graeme; Tucker, Kathy; Chenevix-Trench, Georgia



hI-con1, a factor VII-IgGFc chimeric protein targeting tissue factor for immunotherapy of uterine serous papillary carcinoma  

PubMed Central

Background: Uterine serous papillary adenocarcinoma (USPC) is a highly aggressive variant of endometrial cancer. Human immuno-conjugate molecule (hI-con1) is an antibody-like molecule targeted against tissue factor (TF), composed of two human Factor VII (fVII) as the targeting domain, fused to human immunoglobulin (Ig) G1 Fc as an effector domain. We evaluated hI-con1 potential activity against primary chemotherapy-resistant USPC cell lines expressing different levels of TF. Methods: A total of 16 formalin-fixed, paraffin-embedded USPC samples were evaluated by immunohistochemistry (IHC) for TF expression. Six primary USPC cell lines, half of which overexpress the epidermal growth factor type II (HER2/neu) receptor at 3+ levels, were assessed by flow cytometry and real-time PCR for TF expression. Sensitivity to hI-con1-dependent cell-mediated cytotoxicity (IDCC) was evaluated in 5-hour-chromium release assays. Finally, to investigate the effect of interleukin-2 (IL-2) on IDCC, 5-h 51Cr assays were also conducted in the presence of low doses of IL-2 (i.e., 50–100?IU?ml?1). Results: Cytoplasmic and/or membrane TF expression was observed in all 16 (100%) USPC samples tested by IHC, but not in normal endometrium. High expression of TF was found in 50% (three out of six) of the USPC cell lines tested by real-time PCR and flow cytometry when compared with normal endometrial cells (NECs; P<0.001). Uterine serous papillary adenocarcinoma cell lines overexpressing TF, regardless of their high or low HER2/neu expression, were highly sensitive to IDCC (mean killing±s.d., 65.6±3.7%, range 57.5–77.0%, P<0.001), although negligible cytotoxicity against USPC was seen in the absence of hI-con1 or in the presence of Rituximab control antibody. The addition of low doses of IL-2 further increased the cytotoxic effect induced by hI-con1 against chemotherapy-resistant USPC. Conclusion: hI-con1 induces strong cytotoxicity against primary chemotherapy-resistant USPC cell lines overexpressing TF. The hI-con1 may represent a novel therapeutic agent for the treatment of patients harbouring advanced, recurrent and/or metastatic USPC refractory to standard treatment modalities. PMID:20700124

Cocco, E; Hu, Z; Richter, C E; Bellone, S; Casagrande, F; Bellone, M; Todeschini, P; Krikun, G; Silasi, D-A; Azodi, M; Schwartz, P E; Rutherford, T J; Buza, N; Pecorelli, S; Lockwood, C J; Santin, A D



The Temporal and Spatial Quantification of Holocene Sediment Dynamics for Reconstructing Soil Erosion: Pros, Cons and Challenges  

NASA Astrophysics Data System (ADS)

Since the early beginning of farming, humans have a strong impact on the landscape, on its land cover and therefore on the sediment dynamics. It is assumed that an increase of farming activity is documented by truncated soil profiles due to soil erosion on the slopes and deposition of the eroded material as colluvium and alluvium at foot-slope positions and in floodplains of rivers. In this respect, these sediment archives play a major role in reconstructing human induced soil erosion and in establishing catchment wide quantitative sediment budgets. However, the response of sediment archives to an external impact like the human impact on the landscape or climate events is not homogeneous within a catchment, but might be variable in time and space. This is well known and considered in the geomorphological concept of sediment cascade systems and therefore needs to be included as a basic idea in studies on past soil erosion and its driving factors, using sediment archives. However, the identification of representative sediment archives within a catchment and especially their temporal quantification is challenging. In this presentation I will discuss the importance of sediment archives for reconstruction past soil erosion, the significance of these archives for identifying possible causes of sediment redistribution and the pros, cons and challenges, which are involved.

Fuchs, Markus



Virgin Caenorhabditis remanei females are attracted to a coital pheromone released by con-specific copulating males  

PubMed Central

The gonochoristic soil nematode Caenorhabditis remanei strictly requires copulation for species propagation. Males of this species are sexually promiscuous with females of other species; therefore, we asked in this study whether virgin C. remanei females display evidence of mate choice. We digitally recorded and measured the locomotor behaviors of one or more virgin females in the presence of a single male on a 5 mm diameter mating lawn. We observed that initially only the male modifies his locomotor trajectory to another animal on the mating lawn; the virgin females showed no locomotor bias toward the mate-searching male. However, once a male started to copulate, females in the vicinity altered their movement trajectories toward the copulating couple. Newly inseminated females are refractive to the coital signal, but partially regain their attraction to copulating males after 24 h. We found only copulating males with an intact gonad can attract females, and that the coital signal can be broadcasted at least 1.5 mm through the air. Unlike males, which are also attracted to hetero-specific females, virgin C. remanei females will only crawl toward a copulating con-specific male. We suggest that Caenorhabditis females use the coital signal as a pheromone to identify a vigorous male of their own species. PMID:24058874

Markert, Mathew; Garcia, Luis Rene



Evaluation of GO_CONS_GCF_2_TIM and GOCO01S Geopotential Models in Venezuela and Caribbean Region  

NASA Astrophysics Data System (ADS)

This paper shows two maps of the magnitude of the surface gravity vector (MSGV) of Venezuela and Caribbean region at 1:500.000 scale in the geographic window between the 0-20 north latitude and 74-58 western longitude (Fig. 1 and Fig. 2), that were generated from GOCE gravity gradients data provided by the European Space Agency (ESA). The maps that are showed come from the combined global gravity field model GOCO01s [GOCO Consortium., 2010] and from the satellite-only global gravity field model GO_CONS_GCF_2_TIM [Pail et al., 2010], both of 224 degree. The DEMs used for the evaluation of the MSGV are: Etopo2v2 [NGDC., 2006] and Etopo1 [Amante and Eakins, 2009] respectively. The data processing was done using: Shm2func [ICGEM., 2007]; Goce User Toolbox [ESA., 2009]; Gravsoft package [Tscherning et al., 1992] and Oasis Montaj (Geosoft). This research shows a review of observed gravity in the main geological provinces of the Venezuela and Caribbean region geography, revealing gravitational features important of the geological structures that are in Venezuelan and Caribbean subsurface.

Orihuela, N. D.; Garcia, A. D.; Tabare, T.; Scientific Team Of Venezuelan; Caribbean Crustal Study From Satellital Data



[Sedation concepts with volatile anaesthetics in intensive care: practical use and current experiences with the AnaConDa system].  


The use of volatile anaesthetics in intensive care medicine has so far been limited by the lack of equipment suitable for daily routine use and the need for an anaesthetic machine. The new Anaesthetic Conserving Device (AnaConDa) enables the routine use of volatile anaesthetics for long-term sedation via intensive care ventilators. The Anaesthetic Conserving Device replaces the common heat and moisture exchanger in the ventilation circuit. The volatile anaesthetic is continuously applied in liquid status via a syringe pump to a form of mini-vaporiser where the anaesthetic agent is vaporised. The expired anaesthetic gas is stored in the carbon filter and approximately 90% of the gas is resupplied into the breathing cycle. The current experiences suggest that volatile anaesthetics present an alternative for long-term sedation in intensive care units, providing optimised pathways, from a medical as well as from an economical point of view. It must, however, be emphasized that the use of volatile anaesthetics for longer periods of time is an off-label use and should only undertaken by medical professionals at their own risk. PMID:18839123

Kompardt, J; Schärff, K; Kubosch, K; Pohl, C; Bomplitz, M; Soukup, J



Document-level classification of CT pulmonary angiography reports based on an extension of the ConText algorithm.  


In this paper we describe an application called peFinder for document-level classification of CT pulmonary angiography reports. peFinder is based on a generalized version of the ConText algorithm, a simple text processing algorithm for identifying features in clinical report documents. peFinder was used to answer questions about the disease state (pulmonary emboli present or absent), the certainty state of the diagnosis (uncertainty present or absent), the temporal state of an identified pulmonary embolus (acute or chronic), and the technical quality state of the exam (diagnostic or not diagnostic). Gold standard answers for each question were determined from the consensus classifications of three human annotators. peFinder results were compared to naive Bayes' classifiers using unigrams and bigrams. The sensitivities (and positive predictive values) for peFinder were 0.98(0.83), 0.86(0.96), 0.94(0.93), and 0.60(0.90) for disease state, quality state, certainty state, and temporal state respectively, compared to 0.68(0.77), 0.67(0.87), 0.62(0.82), and 0.04(0.25) for the naive Bayes' classifier using unigrams, and 0.75(0.79), 0.52(0.69), 0.59(0.84), and 0.04(0.25) for the naive Bayes' classifier using bigrams. PMID:21459155

Chapman, Brian E; Lee, Sean; Kang, Hyunseok Peter; Chapman, Wendy W



Tissue factor expression in ovarian cancer: implications for immunotherapy with hI-con1, a factor VII-IgGF(c) chimeric protein targeting tissue factor.  


We evaluated the expression of tissue factor (TF) in ovarian cancer (EOC) and the potential of hI-con1, an antibody-like molecule targeting TF, as a novel form of therapy against chemotherapy-resistant ovarian disease. We studied the expression of TF in 88 EOC by immunohistochemistry (IHC) and real-time-PCR (qRT-PCR) and the levels of membrane-bound-complement-regulatory-proteins CD46, CD55 and CD59 in primary EOC cell lines by flow-cytometry. Sensitivity to hI-con1-dependent-cell-mediated-cytotoxicity (IDCC), complement-dependent-cell-cytotoxicity and inhibition of IDCC by ?-immunoglobulin were evaluated in 5-h (51)chromium-release-assays. Cytoplasmic and/or membrane TF expression was observed in 24 out of 25 (96%) of the EOC samples tested by IHC, but not in normal ovarian-tissue. EOC with clear cell histology significantly overexpress TF when compared to serous, endometrioid, or undifferentiated tumors by qRT-PCR. With a single exception, all primary EOC that overexpressed TF demonstrated high levels of CD46, CD55 and CD59 and regardless of their histology or resistance to chemotherapy, were highly sensitive to IDCC. The effect of complement and physiologic doses of ?-immunoglobulin on IDCC in ovarian cancer cell lines overexpressing TF was tumor specific and related to the overexpression of CD59 on tumor cells. Small-interfering-RNA-mediated knockdown of CD59 expression in ovarian tumors significantly increased hI-con1-mediated cytotoxic activity in vitro. Finally, low doses of interleukin-2 further increased the cytotoxic effect induced by hI-con1 (P < 0.01). hI-con1 molecule induces strong cytotoxicity against primary chemotherapy-resistant ovarian cancer cell lines overexpressing TF and may represent a novel therapeutic agent for the treatment of ovarian tumors refractory to standard treatment modalities. PMID:21725665

Cocco, Emiliano; Varughese, Joyce; Buza, Natalia; Bellone, Stefania; Lin, Ken-Yu; Bellone, Marta; Todeschini, Paola; Silasi, Dan-Arin; Azodi, Masoud; Schwartz, Peter E; Rutherford, Thomas J; Carrara, Luisa; Tassi, Renata; Pecorelli, Sergio; Lockwood, Charles J; Santin, Alessandro D



Tissue factor expression in ovarian cancer: implications for immunotherapy with hI-con1, a factor VII-IgGFc chimeric protein targeting tissue factor  

PubMed Central

We evaluated the expression of tissue factor (TF) in ovarian cancer (EOC) and the potential of hI-con1, an antibody-like molecule targeting TF, as a novel form of therapy against chemotherapy-resistant ovarian disease. We studied the expression of TF in 88 EOC by immunohistochemistry (IHC) and real-time-PCR (qRT-PCR) and the levels of membrane-bound-complement-regulatory-proteins CD46, CD55 and CD59 in primary EOC cell lines by flow-cytometry. Sensitivity to hI-con1-dependent-cell-mediated-cytotoxicity (IDCC), complement-dependent-cell-cytotoxicity and inhibition of IDCC by ?-immunoglobulin were evaluated in 5-h 51chromium-release-assays. Cytoplasmic and/or membrane TF expression was observed in 24 out of 25 (96%) of the EOC samples tested by IHC, but not in normal ovarian-tissue. EOC with clear cell histology significantly overexpress TF when compared to serous, endometrioid, or undifferentiated tumors by qRT-PCR. With a single exception, all primary EOC that overexpressed TF demonstrated high levels of CD46, CD55 and CD59 and regardless of their histology or resistance to chemotherapy, were highly sensitive to IDCC. The effect of complement and physiologic doses of ?-immunoglobulin on IDCC in ovarian cancer cell lines overexpressing TF was tumor specific and related to the overexpression of CD59 on tumor cells. Small-interfering-RNA-mediated knockdown of CD59 expression in ovarian tumors significantly increased hI-con1-mediated cytotoxic activity in vitro. Finally, low doses of interleukin-2 further increased the cytotoxic effect induced by hI-con1 (P < 0.01). hI-con1 molecule induces strong cytotoxicity against primary chemotherapy-resistant ovarian cancer cell lines overexpressing TF and may represent a novel therapeutic agent for the treatment of ovarian tumors refractory to standard treatment modalities. PMID:21725665

Cocco, Emiliano; Varughese, Joyce; Buza, Natalia; Bellone, Stefania; Lin, Ken-Yu; Bellone, Marta; Todeschini, Paola; Silasi, Dan-Arin; Azodi, Masoud; Schwartz, Peter E.; Rutherford, Thomas J.; Carrara, Luisa; Tassi, Renata; Pecorelli, Sergio; Lockwood, Charles J.



Impact evaluation of an adjustable speed drive installed at Ball-InCon Glass Packaging Corporation under the Energy $avings Plan  

SciTech Connect

This impact evaluation of an adjustable speed drive that was recently installed at Ball-InCon Glass Packaging Corporation (Ball-InCon) was conducted for the Bonneville Power Administration (Bonneville) as part of an evaluation of its Energy $avings Plan (E$P) Program. The Program makes acquisition payments to firms that install energy conservation projects in their industrial processes. The objective of this impact evaluation was to assess how much electrical energy is being saved at Ball-InCon as a result of the E$P and to determine how much the savings cost Bonneville and the region. The impact of the project was evaluated with a combination of engineering analysis, financial analysis, interviews, and submittal reviews (Ball-InCon`s Abstract, Proposal, and Completion Report). The project consists of switching from inlet guide vanes to adjustable frequency drives for 10 motors that provide cooling air to glass container molds. Based on this impact evaluation, energy savings from this project are expected to be 1,711,500 kWh/yr, or about 0.20 average megawatts. On a per-ton basis, this project will save approximately 7.8 kWh/ton of glass produced. The project cost $182,834 to install, and Ball-InCon received payment of $95,581 from Bonneville for the acquisition of energy savings. The real levelized cost of these energy savings to Bonneville is 5.2 mills/kWh over the projects`s assumed 15-year life, and the levelized cost to the region is 10.7 mills/kWh in 1992 dollars, not including transmission and distribution effects. This project would not have been implemented without the acquisition payment from Bonneville, so all of the energy savings can be attributed to the E$P.

Spanner, G.E.; Sullivan, G.P.



Supine percutaneous nephrolithotomy: con.  


Advocates of supine percutaneous nephrolithotomy (PCNL) consider several theoretical advantages for this procedure. Despite the potential advantages of the supine PCNL, the majority of urologists have remained reluctant to perform this technique. This reluctance may be related to successful outcomes of prone PCNL and technical difficulties associated with supine PCNL. Feasibility of supine PCNL has been shown in different series and the current evidence, although limited and not fully organized, implies the application of this technique for patients with simple stones who are at high anesthesiological risk. However, there is no convincing evidence to support performing supine PCNL in morbidly obese patients and those with complex and multiple stones. Further randomized clinical trials of large sample size and high methodological quality are required to recommend extensive application of supine PCNL as an alternative to prone PCNL. PMID:22090043

Lashay, Alireza; Amini, Erfan; Ahanian, Ali; Ozhand, Ardalan; Nikkar, Mohammad Masoud; Sharifi, Seyed Hossein Hosseini



Neo-Conned University  

ERIC Educational Resources Information Center

Censorship, says Australian political theorist John Keane (1991), can "echo within us, take up residence within ourselves, spying on us, a private amanuensis who reminds us never to go too far... It makes us zip our lips, tremble and think twice" (p. 39). It can also make us sick. The author states that this is her argument here: that,…

Jones, Andee



Adelante con animo  

E-print Network

A proposition of this thesis is that architecture is capable of conveying a sense of animation, movement and energy. These are elusive properties. Their perception perhaps emerges from the building's form or articulation ...

McCullough Maker, Kathleen Grace



Circumcision: Pros and cons  

PubMed Central

Circumcision is possibly the most frequently performed elective surgical procedure in men. It can simply be described as the excision of the preputium. There have been several studies about the association between circumcision and urinary tract infections (UTI). Many studies have demonstrated that the frequency of UTI increase in uncircumcised males, especially in the first year of life. This review discusses the embryology of the preputium, epidemiology, indications, complications and benefits of circumcision, as well as operation and anesthesiology techniques. It especially examines the association between UTI and circumcision and the importance of circumcision in congenital urinary system anomalies. In addition, this review examines the associations between circumcision and sexually transmitted diseases, including HIV, and the protective role of circumcision on penile cancer. PMID:20535279

Burgu, Berk; Aydogdu, Ozgu; Tangal, Semih; Soygur, Tarkan



Divestment: Pro and Con.  

ERIC Educational Resources Information Center

Both sides of the divestment controversy are presented by two trustees from Carleton College and actions that Carleton finally took are explained. Morgan calls for divestment, while Trow sees colleges as committed to the pursuit of truth, not the possessor. (MLW)

Trow, Martin B.; Morgan, Thomas



The Classics, Con Brio  

ERIC Educational Resources Information Center

Sponsored by a consortium of 30 American universities, Rome's Intercollegiate Center for Classical Studies offers a year of study to American undergraduate classics majors. Instructors are also American and normally stay only a year; teaching assistants are always ex-students of the center. Extensive field trips are an important part of the…

Hansen, James



urban ConAgraculture  

Microsoft Academic Search

Current pressures in today’s world caused me to investigate strategies of change in the organization of society to promote a more effi cient existence. Globalization, a movement characterized by the dissemination of economies, ethnicities, media, ideas, technologies, and production; has become today’s reality. The shift from imperialism to globalism has caused a decline in the power and importance of nation

Dale J Luebbert



Entrevista con José Triana  

E-print Network

una historia banal. El verdadero furor de esos muchachos no es el vaso que se rompe ni el grito por que se apague el radio. Lo que ellos quieren es que el mundo esté mejor ordenado y que el amor ocupe un lugar justo entre ellos, y no ese desorden.... La obra también es un canto al amor. Por un lado está el juego político, el juego heroico, la guerra, el furor de la guerra, etc., y están esos hombres debatiéndose, hablando de un mismo amor, de un amor hacia lo invisible. Creo que la verdadera...

Vasserot, Christilla




The authors also gratefully acknowledge the copy editing assistance of Leslie Alter, MPH and Steve Brown. The Ethical Force Program’s initiative on patient-centered communication is funded in part by the American Medical Association Foundation, The California Endowment, the Commonwealth Fund and the Connecticut Health Foundation.


Riesgos y desafíos en la implementación de una indicación geográfica (IG) Las denominaciones de origen (DO) y las indicaciones geográficas (IG) como herramientas para el desarrollo territorial rural con identidad cultural (DTR-IC)  

Microsoft Academic Search

La presente comunicación es resultado de un Estudio Complementario que se está desarrollando en la ciudad de Colonia Caroya, provincia de Córdoba (Argentina) sobre Indicaciones Geográficas (IG) y Desarrollo Territorial Rural con Identidad Cultural (DTR-IC). El trabajo se inserta en el marco de dos proyectos, por un lado, el Proyecto Desarrollo Territorial Rural con Identidad Cultural (DTR-IC) liderado por Claudia

Marcelo Champredonde; A. Benedetto



Verde Sport S.p.A. con il patrocinio di Assicurazioni Generali e il sostegno di Telecom Italia, bandisce un concorso per il conferimento di 6 premi del valore di 1.000 euro ciascuno a favore di laureati in  

E-print Network

e sport (; Impiantistica sportiva (; Doping sportivo, sia comeBIBLIOTECA STEFANO BENETTON Verde Sport S.p.A. con il patrocinio di Assicurazioni Generali e il ciascuno a favore di laureati in Università italiane con tesi su temi riguardanti lo sport o la

Guidoni, Leonardo



Microsoft Academic Search

Las Cooperativas de Crédito deben destinar un porcentaje de su excedente al Fondo de Educación y Promoción,, por un importe mínimo del 10% del mismo, incluso por la parte procedente de los resultados extracooperativos. Sin duda, es el sector cooperativo con mayores excedentes, y con mayor volumen de FEP a gestionar. Tanto la Ley 20\\/90 de régimen fiscal de las



Accessory cell function in the Con A response: role of Ia-positive and Ia-negative accessory cells.  


We have examined the role of Ia-positive and Ia-negative accessory cells (AC) and soluble factors in Con A-stimulated murine T cell activation. Supernatant fluids containing interleukin 1 (IL 1) derived from the P388D1 macrophage cell line and from a lipopolysaccharide (LPS)-stimulated macrophage hybridoma provided only partial reconstitution of the response of purified T cells (18 to 27%). The complete reconstitution obtained with gamma-irradiated spleen cells or LPS-activated B cells was inhibited by approximately 60 to 77% when anti-Ia antibody was included in the culture. Despite this apparent involvement of Ia+ spleen AC, Ia-negative L cell AC could also reconstitute the response of both Class I-restricted Lyt-2+ T cells and Class II-restricted L3T4+ T cells. When the Ia-negative AC were employed, the L3T4 antigen on L3T4+ T cells played a critical role because addition of anti-L3T4 antibody to the culture inhibited the response by 85 to 90%. In contrast, anti-L3T4 did not inhibit the response in the presence of spleen AC. These results suggest that the molecules involved in T cell-AC interactions may vary depending on the AC source. Moreover, at least one of the putative target ligands for L3T4 presumably is not Ia, because anti-L3T4 inhibited T cell stimulation when Ia-negative AC were used. PMID:3881521

Bekoff, M; Kakiuchi, T; Grey, H M



An inevitable wave of prescription drug monitoring programs in the context of prescription opioids: pros, cons and tensions  

PubMed Central

Background In an effort to control non-medical use and/or medical abuse of prescription drugs, particularly prescription opioids, electronic prescription drug monitoring programs (PDMP) have been introduced in North-American countries, Australia and some parts of Europe. Paradoxically, there are simultaneous pressures to increase opioid prescribing for the benefit of individual patients and to reduce it for the sake of public health, and this pressure warrants a delicate balance of appropriate therapeutic uses of these drugs with the risk of developing dependence. This article discusses pros and cons of PDMP in reducing diversion of prescription opioids, without hampering access to those medications for those with genuine needs, and highlights tensions around PDMP implementation. Discussion PDMPs may help alleviate diversion, over-prescription and fraudulent prescribing/dispensing; prompt drug treatment referrals; avoid awkward drug urine test; and inform spatial changes in prescribing practices and help designing tailored interventions. Fear of legal retribution, privacy and data security, potential confusion about addiction and pseudo-addiction, and potential undue pressure of detecting misuse/diversion - are the major problems. There are tensions about unintended consequence of excessive regulatory enforcements, corresponding collateral damages particularly about inadequate prescribing for patients with genuine needs, and mandatory consultation requirements of PDMP. Summary In this era of information technology PDMP is likely to flourish and remain with us for a long time. A clear standard of practice against which physicians’ care will be judged may expedite the utilisation of PDMP. In addition, adequate training on addiction and pain management along with public awareness, point-of-supply data entry from pharmacy, point-of-care real-time access to data, increasing access to addiction treatment and appropriate regulatory enforcement preferably through healthcare administration, together, may help remove barriers to PDMP use. PMID:25127880



How many metal atoms are needed to dehydrogenate an ethylene molecule on metal clusters?: Correlation between reactivity and electronic structures of Fen+, Con+, and Nin+.  


The absolute cross section for dehydrogenation of an ethylene molecule on Mn+ [Fen+ (n = 2-28), Con+ (n = 8-29), and Nin+ (n = 3-30)] was measured as a function of the cluster size n in a gas-beam geometry at a collision energy of 0.4 eV in the center-of-mass frame in an apparatus equipped with a tandem-type mass spectrometer. It is found that (1) the dehydrogenation cross section increases rapidly above a cluster size of approximately 18 on Fen+, approximately 13 and approximately 18 on Con+, and approximately 10 on Nin+ and (2) the rapid increase of the cross section for Mn+ occurs at a cluster size where the 3d electrons start to contribute to the highest occupied levels of Mn+. These findings lead us to conclude that the 3d electrons of Mn+ play a central role in the dehydrogenation on Mn+. PMID:17029478

Ichihashi, Masahiko; Hanmura, Tetsu; Kondow, Tamotsu



Introduccion. Una matriz de m filas y n columnas con elementos en el cuerpo K es un rectangulo de elementos de K (es decir, numeros) del tipo  

E-print Network

Matrices Introducci´on. Una matriz de m filas y n columnas con elementos en el cuerpo K es un rect ... ... ... ... am1 am2 · · · amn . El elemento aij est´a en la fila i y la columna j. Notaremos por Mm�n(K) al + · · · + ainbnj. El elemento pij es el producto escalar de fila i de la matriz A y la columna j de la matriz B

Ramírez-Ros, Rafael


Disneyland Pars lanza su campaa de seleccin de personal en Alicante con la colaboracin de la Universidad de Alicante y el Ayuntamiento  

E-print Network

Disneyland París lanza su campaña de selección de personal en Alicante con la colaboración de la Universidad de Alicante y el Ayuntamiento Alicante, 2 de diciembre de 2011 Disneyland París en colaboración general. Los interesados que quieran trabajar en Disneyland Paris pueden inscribirse en el enlace www

Escolano, Francisco


Li storage and impedance spectroscopy studies on Co3O4, CoO, and CoN for Li-ion batteries.  


The compounds, CoN, CoO, and Co3O4 were prepared in the form of nano-rod/particles and we investigated the Li-cycling properties, and their use as an anode material. The urea combustion method, nitridation, and carbothermal reduction methods were adopted to prepare Co3O4, CoN, and CoO, respectively. X-ray diffraction (XRD), scanning electron microscope (SEM), transmission electron microscope (TEM), and the Brunauer-Emmett-Teller (BET) surface and density methods were used to characterise the materials. Cyclic voltammetry (CV) was performed and galvanostatic cycling tests were also conducted up to 60-70 cycles. The observed reversible capacity of all compounds is of the increasing order CoO, Co3O4, CoN and all compounds showed negligible capacity fading. CoO allows for Li2O and Co metal to form during the discharge cycle, allowing for a high theoretical capacity of 715 mA h g(-1). Co3O4 allows for 4 Li2O and 3Co to form, and has a theoretical capacity of 890 mAhg(-1). CoN is the best anode material of the three because the nitrogen allows for Li3N and Co to form, resulting in an even higher theoretical capacity of 1100 mAhg(-1) due to the Li3N and Co metal formation. Irrespective of morphology the charge profiles of all three compounds showed a major plateaux ~2.0 V vs. Li and potential values are almost unchanged irrespective of crystal structure. Electrochemical impedance spectroscopy (EIS) was performed to understand variation resistance and capacitance values. PMID:24325322

Reddy, M V; Prithvi, Gundlapalli; Loh, Kian Ping; Chowdari, B V R



Canadian Shield brine from the Con Mine, Yellowknife, NT, Canada: Noble gas evidence for an evaporated Palaeozoic seawater origin mixed with glacial meltwater and Holocene recharge  

Microsoft Academic Search

Dissolved noble gas concentrations were measured in high salinity (270g\\/L) Ca(Na)-Cl groundwaters from the Con Mine, Yellowknife, Canada in an effort to discriminate between two possible origins, as either a brine generated by evaporative enrichment in a Paleozoic inland sea, or marine water concentrated by freezing during glacial times. Major ion and isotope geochemistry indicate that brines from the deepest

Shane Greene; Nick Battye; Ian Clark; Tom Kotzer; Dennis Bottomley



An appraisal of a column-generation-based algorithm for a centralized train-con?ict resolution on metropolitan railway network  

Microsoft Academic Search

In practice, a train-con?ict resolution is decentralized around the dispatchers each of whom, with her rule-of-thumb to operational data, controls a few segments from a global railway network. Conceptually, a global sub-optimality or infeasibility of the decentralized system is resolved by a network controller on the top of the lower layers of the dispatchers and the drivers operating trains on

Sung-Pil Hong; Yun-Hong Min; Soon-Heum Hong


1.0 What is Statistics? 1.1 What is Mathematical Statistics? Random Data Basic Ideas in Statistics 1.2 Fundamental Con Mathematical Statistics  

E-print Network

§1.0 What is Statistics? §1.1 What is Mathematical Statistics? Random Data Basic Ideas in Statistics §1.2 Fundamental Con Mathematical Statistics Zhang, Lixin and Dai, Jialing Course Website: #12;§1.0 What is Statistics? §1.1 What is Mathematical Statistics? Random Data Basic Ideas

Zhang, Li-Xin


Estructura de preferencias de los consumidores de vino y actitudes hacia los vinos con Denominacion de Origen. El caso de Castilla-La Mancha  

Microsoft Academic Search

El trabajo ha cubierto un doble objetivo, por un lado se ha determinado la importancia relativa de los atributos del vino que influyen en la conformaci�n de las preferencias de los consumidores de Castilla-La Mancha, y por otro se ha analizado la actitud de los consumidores hacia los vinos con certificaci�n de Denominaci�n de Origen (D.O.) m�s importantes de Castilla-La

Rodolfo Bernabeu; Miguel Olmeda; Monica Diaz



Sviluppo di una micro CT con sorgente Quasi-Monocromatica Multi-Energy per lo studio in vivo della crescita e della metastasi tumorale  

Microsoft Academic Search

Un innovativo micro scanner CT per piccolo animali - basato su di una sorgente che genera una coppia di fasci X Quasi-Monocromatici paralleli con diverse energie selezionabili - è in corso di installazione e caratterizzazione al Dipartimento d i Fisica dell'Università di Bologna. Lo scopo della ricerca è quello di effettuare l'ima ging radiologico in vivo del tessuto tumorale e\\/o

G. Baldazzi; S. Masetti; P. L. Rossi; L. Roma; G. Nicoletti; P. L. Lollini


arXiv:0802.1511v1[cond-mat.supr-con]11Feb2008 Calculations for Magnetism in SQUIDs at Millikelvin Temperatures  

E-print Network

arXiv:0802.1511v1[cond-mat.supr-con]11Feb2008 Calculations for Magnetism in SQUIDs at Millikelvin SQUIDs. PACS numbers: 85.25.Dq, 03.65.Yz, 74.40.+k, 74.25.Ha Our recent measurements show an unexpected depen- dence of SQUID flux on bath temperature. The flux change scales as 1/T as temperature is lowered

Martinis, John M.


A methodological approach to comparing pros and cons of delocalizing villages: socio-economic and technical issues  

NASA Astrophysics Data System (ADS)

On 7th March 2005, prolonged rainfalls combined with snowfalls activated a wide complex rock slide-earth flow that partly destroyed the village of Cavallerizzo at Cerzeto (Calabria, Southern Italy). Superposed tectonic units made of Palaeozoic metamorphic rocks, overlain by Miocene-Quaternary clastic terrains, crop out in the study area. The main scarp of the landslide developed by a recent normal fault, striking N-S along the western margin of the Crati graben and extended ca. 25 km. In its lower part, the phenomenon evolved in two main earth-flow bodies that extended along minor drainages and then merged along the S. Nicola torrent. The sector affected by the instability actually belongs to a large-scale slope movement: the 2005 activation was in fact only a paroxysmal episode of a long history of slope deformations, noticed in the area since the XVIII century. Warning signs had been recorded for weeks before the collapse, and the threatened area had been put under monitoring by CNR-IRPI. When the movement accelerated, people had already been alerted and evacuated (329 out of 581 inhabitants of Cerzeto were sheltered in nearby villages), thus neither victims nor injured were recorded. As a whole, 124 buildings were severely damaged or destroyed, the main road was interrupted. Immediately after the 7th March 2005 event, the national Department for Civil Protection decided to evaluate the feasibility of delocalizing Cavallerizzo to another site. At this purpose, CNR-IRPI was asked to analysing the "geological suitability" of 3 different sites (Pianette, Amatine, and Colombra), pre-selected by the same Municipality of Cerzeto in accordance to the Civil Protection; the results of the study were completed in early Summer 2005. Between October 2007 and December 2011, a new settlement was realized by the Italian Government, and the houses were delivered to people once living at Cavallerizzo. In the last years, the socio-economic effects of the delocalization of Cavallerizzo have been analysed within the frame of a PhD thesis by one of the authors. The present study focuses on the Cavallerizzo case study to discuss a methodological approach useful to comparing pros and cons of delocalizing villages, aiming at properly considering socio-economic effects in addition to technical issues.

Guadagno, Eleonora; Iovine, Giulio G. R.; Petrucci, Olga; Forciniti, Pinuccia R.



Emerging and Legacy Contaminants in The Foodweb in The Lower Columbia River: USGS ConHab Project  

NASA Astrophysics Data System (ADS)

An interdisciplinary study, USGS Columbia River Contaminants and Habitat Characterization (ConHab) project, investigates transport pathways, chemical fate, and effects of polybrominated diphenyl ethers (PBDEs) and other endocrine disrupting chemicals (EDCs) in aquatic media and the foodweb in the lower Columbia River, Oregon and Washington. Polar organic chemical integrative samplers (POCIS) and semipermeable membrane devices (SPMDs) were co-deployed at each of 10 sites in 2008 to provide a measure of the dissolved concentrations of select PBDEs, chlorinated pesticides, and other EDCs. PBDE-47 was the most prevalent of the PBDEs detected. Numerous organochlorine pesticides, both banned and current-use, including hexachlorobenzene, pentachloroanisole, dichlorodiphenyltrichloroethane (DDT) and its degradates, chlorpyrifos, endosulfan, and the endosulfan degradation products, were measured at each site. EDCs commonly detected included a series of polycyclic aromatic hydrocarbons (PAHs), fragrances (galaxolide), pesticides (chlorpyrifos and atrazine), plasticizers (phthalates), and flame retardants (phosphates). The downstream sites tended to have the highest concentrations of contaminants in the lower Columbia River. In 2009 and 2010 passive samplers were deployed and resident largescale suckers (Catostomus macrocheilus) and surface bed sediments were collected at three of the original sites representing a gradient of exposure based on 2008 results. Brain, fillet, liver, stomach, and gonad tissues were analyzed. Chemical concentrations were highest in livers, followed by brain, stomach, gonad, and, lastly, fillet. Concentrations of halogenated compounds in tissue samples ranged from <1 to 400 ng g-1 wet tissue. PBDEs, organochlorine pesticides, DDT and its degradates, and polychlorinated biphenyls (PCBs) were detected at all sites in nearly all organs tested. PBDE congeners most frequently detected and at the highest concentrations were PBDE-47 > PBDE-100 > PBDE-154 > PBDE-153. Concentrations in tissues and in sediments increased moving downstream from Skamania, WA to Columbia City, OR to Longview, WA. Preliminary biomarker results indicate that fish at the downstream sites experience greater stress relative to the upstream site based on gonad, kidney, spleen, and liver histopathology. These results support the hypothesis that contaminant concentrations in the environment correlate to bioaccumulation in the foodweb.

Nilsen, E. B.; Alvarez, D.; Counihan, T.; Elias, E.; Gelfenbaum, G. R.; Hardiman, J.; Jenkins, J.; Mesa, M.; Morace, J.; Patino, R.; Torres, L.; Waite, I.; Zaugg, S.



Fuentes de variabilidad en el diagn?stico de gastritis atr?fica multifocal asociada con la infecci?n por Helicobacter pylori1  

PubMed Central

RESUMEN Introducción El mapeo de las diferentes regiones del estómago y el número de fragmentos de mucosa gástrica disponibles para evaluación histopatológica son fuentes importantes de variación en el momento de clasificar y hacer la gradación de la gastritis crónica. Objetivos Estimar la sensibilidad del número de fragmentos de mucosa gástrica necesarios para establecer los diagnósticos de gastritis atrófica con metaplasia intestinal (MI), displasia y estado de infección por Helicobacter pylori. Además evaluar la variabilidad intra-observador en la clasificación de estas lesiones precursoras del cáncer gástrico. Materiales y métodos En una cohorte de 6 años de seguimiento se evaluaron 1,958 procedimientos de endoscopia realizados por dos gastroenterólogos. En cada procedimiento y de cada participante se obtuvieron 5 biopsias de mucosa gástrica que representaban antro, incisura angularis y cuerpo. Un único patólogo hizo la interpretación histológica de las 5 biopsias y proporcionó un diagnóstico definitivo global que se utilizó como patrón de referencia. Cada fragmento de mucosa gástrica examinado condujo a un diagnóstico individual para cada biopsia que se comparó con el patrón de referencia. La variabilidad intra-observador se evaluó en 127 personas que corresponden a una muestra aleatoria de 20% del total de endoscopias hechas a los 72 meses de seguimiento. Resultados La sensibilidad del diagnóstico de MI y displasia gástrica aumentó de manera significativa con el número de fragmentos de mucosa gástrica evaluados El sitio anatómico de mayor sensibilidad para el diagnóstico de MI y displasia fue la incisura angularis. Para descubrir H. pylori se logró alta sensibilidad con el estudio de un solo fragmento de mucosa gástrica (95.9%) y fue independiente del sitio de obtención de la biopsia. El acuerdo intra-observador para el diagnóstico de gastritis crónica fue 86.1% con valor kappa de 0.79 IC 95% (0.76-0.85). Las biopsias fijadas en alcohol fueron inadecuadas para demostrar H. pylori e interpretar los cambios de displasia. Conclusión El número de fragmentos de mucosa gástrica evaluados, el método de fijación y la región del estómago donde se obtienen las biopsias son factores muy importantes para lograr una correcta clasificación de la gastritis crónica atrófica multifocal.

Bravo, Luis Eduardo; Bravo, Juan Carlos; Realpe, Jose Luis; Zarama, Guillermo; Piazuelo, MarIa Blanca; Correa, Pelayo



Informe Anual a la Nación sobre el Estado del Cáncer, de 1975 a 2010, con una sección especial sobre la prevalencia de comorbilidad y su efecto en la supervivencia de personas con cáncer de pulmón, seno, próstata o colorrectal: preguntas y respuestas

El Informe Anual a la Nación sobre el Estado del Cáncer (1975 a 2010), mostró un descenso más acelerado que en años anteriores de los índices de mortalidad por cáncer de pulmón. También contiene una sección especial que destaca los efectos significativos que tienen otras enfermedades en la supervivencia de pacientes con cáncer.


[Clinico-statistical observations on malignant ocular tumors surgically resolved at the Cluj-Napoca Ophthalmological Clinic between 1970 and 1990].  


During the period mentioned above there ware hospitalized 54 patients having epibulbar tumours. The anatomopathological exam which was effectuated for 33 patients hes shown Bowen's disease for 14 cases, spinocellular carcinoma for 15 patients and basocellular for 3 patients. There were 4 cases for epibulbar precancerous. There was retinoblastoma for 19 cases; it had been practiced the enucleation of ocular globe for 17 patients and for two cases it had been practiced the exenteration of the eye socket. At the same period there were 91 uveal melanosis 6 of which having iridial localization, 10 cases of ciliary body [correction of cylar corpus], 75 cases of choroid. The hepatic scintigraphy was practiced for 56 patients and had shown for 8 cases hepatic metastasis. The histopathological exam of the melanomata of ciliary and choroidal corpus had shown type A fusiform cells for 22 cases, type B for 43 cases, epithelioid cells for 6 cases and mixed type cells for 13 cases. The hepatic metastasis were epithelioid cells for all the cases and, for 2 cases there were with mixed type cells, It is necessary an active discovering of intraocular and episcleral malign tumours, for increasing the chance of an earlier diagnosis during a stadium that would be able to be treated as conservator as possible be. PMID:1520664

Pop, R; Sandovici, E M; Abrudan, L P; Lazarov, E; Petrescu, M; C?lug?ru, M; Marin, C; Vl?du?iu, C; Constantinescu, E



[Intestinal trematodiases (metagonimiasis, nanophyetiasis): clinico-parasitological research and the first trial of using Azinox in a focus of the lower Amur River valley].  


A focus of metagonimiasis and nanophyetiasis is described with the average human prevalence of 66.7 and 4.2%, respectively and low intensity of invasions (less than 100 eggs per 1 g). Metagonimiasis and nanophyetiasis are clinically expressed as chronic enterocolitis. A high effect of a single dose 10 mg/kg of azinox against metagonimiasis (98%) and nanophyetiasis (100%) was shown. The treatment course was proved to be useful in the foci of the Amur basin. PMID:1435530

Bronshte?n, A M; Korablev, V N; Iarotski?, L S



A multi-centre clinico-genetic analysis of the VPS35 gene in Parkinson disease indicates reduced penetrance for disease-associated variants  

PubMed Central

Background Two recent studies identified a mutation (p.Asp620Asn) in the vacuolar protein sorting 35 gene as a cause for an autosomal dominant form of Parkinson disease . Although additional missense variants were described, their pathogenic role yet remains inconclusive. Methods and results We performed the largest multi-center study to ascertain the frequency and pathogenicity of the reported vacuolar protein sorting 35 gene variants in more than 15,000 individuals worldwide. p.Asp620Asn was detected in 5 familial and 2 sporadic PD cases and not in healthy controls, p.Leu774Met in 6 cases and 1 control, p.Gly51Ser in 3 cases and 2 controls. Overall analyses did not reveal any significant increased risk for p.Leu774Met and p.Gly51Ser in our cohort. Conclusions Our study apart from identifying the p.Asp620Asn variant in familial cases also identified it in idiopathic Parkinson disease cases, and thus provides genetic evidence for a role of p.Asp620Asn in Parkinson disease in different populations worldwide. PMID:23125461

Sharma, Manu; Ioannidis, John P A; Aasly, Jan O; Annesi, Grazia; Brice, Alexis; Bertram, Lars; Bozi, Maria; Barcikowska, Maria; Crosiers, David; Clarke, Carl E; Facheris, Maurizio F; Farrer, Matthew; Garraux, Gaetan; Gispert, Suzana; Auburger, Georg; Vilariño-Güell, Carles; Hadjigeorgiou, Georgios M; Hicks, Andrew A; Hattori, Nobutaka; Jeon, Beom S; Jamrozik, Zygmunt; Krygowska-Wajs, Anna; Lesage, Suzanne; Lill, Christina M; Lin, Juei-Jueng; Lynch, Timothy; Lichtner, Peter; Lang, Anthony E; Libioulle, Cecile; Murata, Miho; Mok, Vincent; Jasinska-Myga, Barbara; Mellick, George D; Morrison, Karen E; Meitnger, Thomas; Zimprich, Alexander; Opala, Grzegorz; Pramstaller, Peter P; Pichler, Irene; Park, Sung Sup; Quattrone, Aldo; Rogaeva, Ekaterina; Ross, Owen A.; Stefanis, Leonidas; Stockton, Joanne D; Satake, Wataru; Silburn, Peter A; Strom, Tim M; Theuns, Jessie; Tan, Eng- King; Toda, Tatsushi; Tomiyama, Hiroyuki; Uitti, Ryan J; Van Broeckhoven, Christine; Wirdefeldt, Karin; Wszolek, Zbigniew; Xiromerisiou, Georgia; Yomono, Harumi S; Yueh, Kuo-Chu; Zhao, Yi; Gasser, Thomas; Maraganore, Demetrius; Krüger, Rejko



Clinical evaluation of hydroxyapatite and ?-tricalcium phosphate composite graft in the treatment of intrabony periodontal defect: A clinico-radiographic study  

PubMed Central

Background and Objective: Hydroxyapatite (HA) and ?-tricalcium phosphate (?-TCP) grafts have shown to be effective in promoting the clinical signs of periodontal regeneration in intrabony defects. The aim of our study was to clinically and radiographically evaluate the efficacy of HA and ?-TCP composite bone graft material in the treatment of intrabony three-wall defect. Materials and Methods: Twenty patients participated in this study. Interproximal bony defects were surgically treated with a combination of HA–?TCP (biphasic calcium phosphate). Changes in clinical parameters such as gingival status, probing pocket depth, clinical attachment, and radiographic estimation of the amount of bone fill were evaluated after 6 months postoperatively. Statistical Analysis Used: Student's “t” test. Results: This treatment modality resulted in significant pocket depth reduction and clinical attachment gain which were observed to be 2.938 mm (47.04%) and 3.188 mm (29.09%), respectively. The defect fill as seen radiographically was 3.204 mm (63.195%). All the differences were highly significant and in favor of postoperative group. Conclusion: The results of this study suggest that HA–?TCP (biphasic calcium phosphate) provides an added regenerative effect in promoting the clinical resolution of intrabony three-wall defects in patients with periodontitis.

Bansal, Rajat; Patil, Sudhir; Chaubey, Krishna Kumar; Thakur, Rajesh Kumar; Goyel, Purnita



Clinico-Immunochemical Studies on Airborne Areca catechu L. Pollen, a Probable Risk Factor in Emergency Asthma Hospitalization from Eastern India  

Microsoft Academic Search

Background: The pollen grain of the Areca catechu L. tree is airborne and allergenic. This study aimed to know the role of this pollen as a source of aeroallergen with effect on emergency asthma hospitalization, to isolate its important allergic fraction and to check its cross-reaction with betel nut. Methods:Areca pollen was monitored with a Burkard sampler. Determination of allergenic

Pampa Chakraborty; Jyotshna Mandal; Eva Sarkar; Indrani Chowdhury; Swati Gupta-Bhattacharya



Medical errors and clinical risk management: state of the art Errori medici e gestione del rischio clinico: stato dell'arte  

Microsoft Academic Search

Summary Medical errors represent a serious public health problem and pose a threat to patient safety. All patients are poten- tially vulnerable, therefore medical errors are costly from a human, economic, and social viewpoint. The present report aims not only to provide an overview of the problem on the basis of the published literature, but also to stress the importance




The expression of gene transcripts of telomere-associated genes in human breast cancer: correlation with clinico-pathological parameters and clinical outcome  

Microsoft Academic Search

Background: Telomerase is a ribonucleoprotein enzyme that synthesises telomeres in human germ cells, embryogenesis and in cancer, maintaining\\u000a chromosomal length, stability and cellular immortality. The hTERT gene is the rate-limiting determinant of telomerase reactivation\\u000a during immortalization and malignant transformation. Telomeric DNA-binding proteins have been attracting increasing interest\\u000a due to their essential role in the regulation of telomeric DNA length and

Mohamed Salhab; Wen G. Jiang; Robert F. Newbold; Kefah Mokbel



Hypersensitivity to pollen of four different species of Brassica: a clinico-immunologic evaluation in patients of respiratory allergy in India  

PubMed Central

Background Rapeseed-mustard is the second most important source of edible oil in India. Several species of Brassica are grown in different parts of country for its oilseeds. Objective The objective was to investigate allergenicity to antigenic extracts of pollen of 4 species of Brassica. Methods Brassica campestris, Brassica juncea, Brassica nigra, and Brassica napus were selected for the detailed investigation. Pollen samples from each of the four species were collected from the polliniferous materials. The antigenic and allergenic profiles of these extracts were evaluated by means of sodium dodecyl sulfate-polyacrylamide gel electrophoresis, Skin prick test, enzyme linked immuno sorbent assay and Western blot on atopic individuals. Results Out of the 159 atopic subjects tested, 21.38% were positive to at least one or other species of Brassica pollen, with highest skin positivity (13.20%) to B. campestris extract. Raised IgE with significant linear correlation with intensity of skin reactions was obtained. Protein fractions of 20, 25, 32, 37, 56, and 90 kDa were recognized by B. campestris and B. juncea whereas 56, 76, 87, and 90 kDa were recognized by B. nigra and B. napus as major IgE binding protein fractions. The patients also showed positivity to other inhalant pollen allergens tested. Conclusion IgE mediated hypersensitivity varied from 4.40% to 13.20% in Indian atopic subjects to pollen of one or the other species of Brassica. Protein fractions of 47, 56, 76, 87, and 90 kDa were identified as IgE binding by all the four species, however individual heterogeneity exists. Thus a local species may be more pertinent for immunotherapy. The major allergen needs to be further characterized. PMID:25379479

Shahi, Shipra; Katiyar, Raj Kishore; Gaur, Shailendra; Jain, Vikram



The 8,344 mutation in mitochondrial DNA: A comparison between the proportion of mutant DNA and clinico-pathologic findings  

Microsoft Academic Search

Ten patients, two men and eight women with mitochondrial encephalomyopathy, had an A-G mutation at nucleotide pair 8,344 in the mitochondrial DNA, the most common genetic defect in myoclonus epilepsy with ragged-red fibers (MERRF). Eight patients had the clinical and pathologic characteristics of MERRF including myoclonus, seizures, cerebellar ataxia and myopathy with ragged-red fibers. Two patients had atypical symptoms such

Matsuko Ozawa; Yu-Ichi Goto; Ryoichi Sakuta; Yoshinori Tanno; Shoji Tsuji; Ikuya Nonaka



‘On mind?blindness (optic agnosia)’, a classical clinico?pathological report, and its author Wilhelm von Stauffenberg (1879–1918)  

Microsoft Academic Search

Two photographs from the beginning of our century still instructively illustrate the phenomenon of visual agnosia: the perplexed face of an old lady confronted with objects clears after touching them. This patient with bilateral posterior cerebral infarction was followed for seven years at the Munich Medicine Department of Friedrich von Müller (1858–1941) who had a strong interest in neurology. His

Adrian Danek



A Study on the Clinico-Epidemiological Profile and the Outcome of Snake Bite Victims in a Tertiary Care Centre in Southern India  

PubMed Central

Background: Snake bite is a common medical emergency and an occupational hazard, more so in tropical India, where farming is a major source of employment. The available data on the epidemiology of snake bite from the Indian subcontinent are sparse. Snake bite is a neglected disease that afflicts the most impoverished inhabitants of the rural areas in the tropical developing countries. Aims: This study was carried out to describe the epidemiology, arrival delays, clinical features, complications, and the outcome of snakebites which were seen in a tertiary care hospital of southern India. Setting: Sri Chamarajendra District Hospital which is attached to the Hassan Institute of Medical Sciences, Hassan, Karnataka, India. Study Design: A record–based, retrospective, descriptive study. Materials and Methods: One hundred eighty patients of snake bite were studied from January 2010 to December 2011. The data on the demographic factors, clinical features and complications, details of the treatment which was received and the outcome of the snake bite victims were recorded and analyzed. Results: Among a total 180 cases of snake bite, there were 108 cases of viper bite which presented with haematotoxic manifestations and 74 elapid bites had neuroparalytic manifestations. The victims were predominantly males (60.5%) and they were aged 20-40 years. A majority of the victims are from the rural areas (81.1%) and most of the bites occurred during the day time (70.5%), mainly on the lower limbs (67.2%). The highest number of cases occurred during July- September. Most of the victims were farmers (54.4%) and plantation workers (30.5%), which suggested that snake bite was an occupational hazard. A reaction to the ASV was noted in 12.7% of the patients and the mortality rate in our study was 3.8%. Conclusion: In the tropics, snake bite is a rural and an occupational hazard among farmers, plantation workers, herders and hunters. Regular public health programmes regarding the prevention, pre –hospital management (first aid) and the importance of the early transfer to the hospital should be emphasized. PMID:23450135

B.R., Halesha; L., Harshavardhan; A J., Lokesh; P.K., Channaveerappa; K.B, Venkatesh



Evaluation of immediately loaded dental implants bioactivated with platelet-rich plasma placed in the mandibular posterior region: A clinico-radiographic study  

PubMed Central

Background and Objectives: The purpose of the present study was to clinically and radiographically assess the soft and hard tissue changes around the immediately loaded single tooth implants bioactivated with platelet-rich plasma (PRP), placed in the mandibular posterior region. Materials and Methods: A total of 11 patients having single tooth edentulous space in the mandibular posterior region were selected. An endosseous implant was placed after clinical and radiographic examination in each selected site using single stage surgical approach. The patients were followed up at 3, 6, 9, and at 12 months of post implant insertion. The patients were subjected to recording of clinical parameters like modified plaque index, modified gingival index, probing depth, and clinical implant mobility scale. Radiographs made at different intervals were subjected to assessment of bone level mesial and distal to each implant using computer assisted image analysis. Results: Scores for clinical parameters were minimal and comparable. The probing depth around the implant was measured during the follow-up period and the changes observed were statistically non-significant. None of the implants were clinically mobile during the follow-up period. Radiographically, the peri-implant bone resorption both on mesial and distal sides was within normal limit after one year of immediate loading. Finally, the overall success rate for the immediately loaded bioactivated implant placed in the mandibular posterior region was recorded as 100%. Interpretation and Conclusion: The use of platelet-rich plasma may lead to improved early bone apposition around the implant; and thus, results in increased rate of osseointegration. Single stage implant procedure with the adjunctive use of PRP enhances the ability of peri-implant healing tissue to create favorable soft and hard tissue relationships. It also gives the added advantage of psychological boost for the patient by getting fixed replacement of tooth within a short time period. PMID:22628970

Anand, Ullas; Mehta, D. S.



Short-Term Clinico-Radiographic Response to Super-Selective Intra-Arterial Cerebral Infusion of Bevacizumab for the Treatment of Vestibular Schwannomas in Neurofibromatosis Type 2  

PubMed Central

Summary Neurofibromatosis type 2 (NF2) is an autosomal dominant syndrome with a prevalence of approximately 1 in 30,000. NF 2 is characterized by bilateral vestibular schwannomas, as well as meningiomas, ependymomas and gliomas. Currently, surgical resection and radiotherapy represent the mainstay of treatment, although new studies suggest a role for certain chemotherapeutic agents. Intravenous administration of Bevacizumab (Avastin, Genetech Pharmaceuticals) has been shown to be active in the treatment of vestibular schwannomas. The IV route of administration, however, carries a risk of known systemic side-effects such as bowel perforation, wound dehiscence and pulmonary embolism. In addition, the percentage of drug that reaches the tumor site may be restricted by the blood tumor barrier. This report describes the super-selective intra-arterial infusion of Bevacizumab following blood brain barrier disruption for the treatment of vestibular schwannomas in three patients with Neurofibromatosis type 2. It represents the first time such a technique has been performed for this disease. Additionally, this method of drug delivery may have important implications in the treatment of patients with vestibular schwannomas associated with Neurofibromatosis type 2. PMID:22681725

Riina, H.A.; Burkhardt, J-K.; Santillan, A.; Bassani, L.; Patsalides, A.; Boockvar, J.A.



Towards integrated clinico-genomic models for personalized medicine: combining gene expression signatures and clinical factors in breast cancer outcomes prediction  

Microsoft Academic Search

Abstract: patterns, that we term metagenes, selecting those that are most capable ofresolving the biological heterogeneity. Moreover, this framework provides a mechanism to combine multipleforms of data, both genomic and clinical, to most effectively characterize individual patients and achieve thegoal of personalized predictions of clinical outcomes.INTRODUCTIONRecent advances in genome science and technology define thepotential for increasingly complex biomedical and molecularinformation

Joseph R. Nevins; Erich S. Huang; Holly Dressman; Jennifer Pittman; Andrew T. Huang; Mike West



The many faces of cryoglobulinemic nephropathy: a clinico-pathologic study of 47 cases with emphasis on the value of electron microscopy.  


Abstract The clinical and pathologic manifestations of cryoglobulinemic nephropathy (CN) are heterogeneous. The role that electron microscopy plays in the diagnosis of CN has not been properly evaluated. The main objective of this study was to define the value of ultrastructural evaluation in the diagnosis of CN. Although most of the CN cases in this series exhibited glomerular pathology with a membranoproliferative pattern, a significant number of the cases showed less well-defined morphologic patterns on light microscopic examination (i.e. mesangial proliferation, hyaline thrombi in glomerular capillaries without significant cellular proliferation, exudative glomerulonephritis, etc). Immunofluorescence microscopy also revealed variable immunoglobulin and complement component patterns, some with "full-house" expression of immunoreactants. A subset of these CN cases was associated with light chain restriction. Thus, differential diagnosis can be a challenge as many other glomerulonephritis overlap in immunomorphologic characteristics. Because the immunomorphologic manifestations of CN are so varied, confirmation of a suspected diagnosis of CN or making a diagnosis in a less than a typical immunomorphologic setting required careful ultrastructural evaluation to find unequivocal diagnostic findings or at least supportive evidence in the form of detection of substructure in the electron dense glomerular deposits consistent with cryoglobulins. Even in cases where the light and immunofluorescence findings in suspicious clinical situations were quite consistent with CN, electron microscopy provided the final proof to substantiate the diagnosis in the great majority of the cases. PMID:25191813

Ojemakinde, Kunle; Turbat-Herrera, Elba A; Zeng, Xu; Gu, Xin; Herrera, Guillermo A



Sono convocati per il giorno Mercoled 17 Marzo 2010 alle ore 10.00 presso il salone sindacale i seguenti componenti R.S.U. per il Comitato di Coordinamento con compiti organizzativi interni alla  

E-print Network

seguenti componenti R.S.U. per il Comitato di Coordinamento con compiti organizzativi interni alla R.S.U PORTAVOCE RSU Marotta Stefano #12;I ,,-::Lo\\ 00 COMITATO DI COORDINAMENTO RSU I"marotta, stefano

Guidoni, Leonardo


Potential pros and cons of external healthcare performance evaluation systems: real-life perspectives on Iranian hospital evaluation and accreditation program  

PubMed Central

Background: Performance evaluation is essential to quality improvement in healthcare. The current study has identified the potential pros and cons of external healthcare evaluation programs, utilizing them subsequently to look into the merits of a similar case in a developing country. Methods: A mixed method study employing both qualitative and quantitative data collection and analysis techniques was adopted to achieve the study end. Subject Matter Experts (SMEs) and professionals were approached for two-stage process of data collection. Results: Potential advantages included greater attractiveness of high accreditation rank healthcare organizations to their customers/purchasers and boosted morale of their personnel. Downsides, as such, comprised the programs’ over-reliance on value judgment of surveyors, routinization and incurring undue cost on the organizations. In addition, the improved, standardized care processes as well as the judgmental nature of program survey were associated, as pros and cons, to the program investigated by the professionals. Conclusion: Besides rendering a tentative assessment of Iranian hospital evaluation program, the study provides those running external performance evaluations with a lens to scrutinize the virtues of their own evaluation systems through identifying the potential advantages and drawbacks of such programs. Moreover, the approach followed could be utilized for performance assessment of similar evaluation programs. PMID:25279381

Jaafaripooyan, Ebrahim



Genes related to the very early stage of ConA-induced fulminant hepatitis: a gene-chip-based study in a mouse model  

PubMed Central

Background Due to the high morbidity and mortality of fulminant hepatitis, early diagnosis followed by early effective treatment is the key for prognosis improvement. So far, little is known about the gene expression changes in the early stage of this serious illness. Identification of the genes related to the very early stage of fulminant hepatitis development may provide precise clues for early diagnosis. Results Balb/C mice were used for ConA injection to induce fulminant hepatitis that was confirmed by pathological and biochemical examination. After a gene chip-based screening, the data of gene expression in the liver, was further dissected by ANOVA analysis, gene expression profiles, gene network construction and real-time RT-PCR. At the very early stage of ConA-triggered fulminant hepatitis, totally 1,473 genes with different expression variations were identified. Among these, 26 genes were finally selected for further investigation. The data from gene network analysis demonstrate that two genes, MPDZ and Acsl1, localized in the core of the network. Conclusions At the early stages of fulminant hepatitis, expression of twenty-six genes involved in protein transport, transcription regulation and cell metabolism altered significantly. These genes form a network and have shown strong correlation with fulminant hepatitis development. Our study provides several potential targets for the early diagnosis of fulminant hepatitis. PMID:20398290