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1

Clinico-radiological spectrum of reversible splenial lesions in children.  

PubMed

Recently, many cases of children presenting reversible splenial lesions during febrile illness (RESLEF) have been reported; however, their overall clinico-radiological features are unclear. To describe the clinico-radiological features, we retrospectively reviewed the etiology (pathogen), clinical course, laboratory data, magnetic resonance imaging and electroencephalography (EEG) findings, therapy, and prognosis of 23 episodes in 22 children (1 child recurred) who presented neurological symptoms, with RESLEF. The etiologies (pathogens) varied. Seizure occurred in 7 episodes, disturbance of consciousness (DC) in 13, and delirious behavior in 18. Serum sodium levels <136 mEq/L were observed in 18 episodes. Lesions outside the splenium were found in 4 cases. Slow waves were observed on EEG in 10 episodes. Methylprednisolone pulse therapy was given in 7 cases. No case resulted in neurological sequelae. Among 23 episodes, clinically mild encephalitis/encephalopathy with a reversible splenial lesion (MERS) was diagnosed in 6 episodes, whereas non-MERS was observed in 17 episodes. No difference was observed in almost all the clinico-radiological features' data between the 2 groups. The largest differences were observed in the rate of purposeless movement, DC, extension of the abnormal lesions outside the splenium, and marked slowing of background activity on EEG. RESLEF exhibit a spectrum of clinico-radiological features. These results suggest that non-MERS and MERS both are a part of a larger pathological condition, which we have termed as RESLEF spectrum syndrome. Given the view that such a syndrome exists, the clinical characteristics and position of non-MERS and MERS become clear. PMID:23790266

Kashiwagi, Mitsuru; Tanabe, Takuya; Shimakawa, Shuichi; Nakamura, Michiko; Murata, Shinya; Shabana, Kousuke; Shinohara, Jun; Odanaka, Yutaka; Matsumura, Hideki; Maki, Koh; Okumura, Kenichi; Okasora, Keisuke; Tamai, Hiroshi

2014-04-01

2

INTEGRATED CLINICO-GENOMICS ENVIRONMENT: DESIGN AND OPERATIONAL SPECIFICATION  

Microsoft Academic Search

We present an Integrated Clinico-Genomics Environment (ICGE). The proposed reference architecture provides for the seamless integration of clinical and genomic information, and it is based on the synergy between advanced medical informatics and post-genomics technology. ICGE aims to enhance and support the future genetic and individualised medical environment. Integrated intelligent data processing operations (i.e., data mining) are in the heart

George Potamias; Dimitris Kafetzopoulos; Manolis Tsiknakis

3

Cerebellar liponeurocytoma: a newly recognized clinico-pathological entity.  

PubMed

The term "cerebellar liponeurocytoma", recently adopted by the World Health Organization Working Group (WHO), replaced many other different terms used up to now to give name to this rare tumor. To our knowledge, less than 20 cases have been related up to now under different names like as "lipomatous medulloblastoma, lipidized medulloblastoma, neurolipocytoma, medullocytoma and lipomatous glioneurocytoma". The new nomenclature eliminates the word "medulloblastoma", reinforces its benign character, and includes it in the category of glioneuronal tumors. We describe an addictional case of this distinct clinico-pathological entity removed from the right cerebellar hemisphere of a 53-year-old woman. With the present case report, we hope to contribute to the knowledge on the diagnostic and prognostic implications derived from the finding of mature adipose-like tissue within a medulloblastomatous tumour. PMID:12364938

Montagna, Nádia; Moreira, Daniel; Vaz, Luiz Carlos; Reis, Marcelo

2002-09-01

4

Review of tumoral calcinosis: A rare clinico-pathological entity  

PubMed Central

Tumoral calcinosis (TC) has long been a controversial clinico-pathological entity. Its pathogenesis and genetic background have been gradually unravelled since its first description in 1943. According to the presence or absence of an underlying calcifying disease process, TC has been divided into primary and secondary varieties. Two subtypes of the primary variety exist; a hyper-phosphatemic type with familial basis represented by mutations in GalNAc transferase 3 gene (GALNT3), KLOTHO or Fibroblast growth factor 23 (FGF23) genes, and a normo-phosphatemic type with growing evidence of underlying familial base represented by mutation in SAMD9 gene. The secondary variety is mainly associated with chronic renal failure and the resulting secondary or tertiary hyperparathyroidism. Diagnosis of TC relies on typical radiographic features (on plain radiographs and computed tomography) and the biochemical profile. Magnetic resonance imaging can be done in difficult cases, and scintigraphy reflects the disease activity. Treatment is mainly surgical for the primary variety; however, a stage-oriented conservative approach using phosphate binders, phosphate restricted diets and acetazolamide should be considered before the surgical approach is pursued due to the high rate of recurrences and complications after surgical intervention. Medical treatment is the mainstay for treatment of the secondary variety, with failure warranting subtotal or total parathyroidectomy. Surgical intervention in these patients should be kept as a last resort. PMID:25232542

Fathi, Ibrahim; Sakr, Mahmoud

2014-01-01

5

[Improving the clinico-microbiological diagnosis and treatment of non-clostridial anaerobic peritonitis].  

PubMed

On the basis of clinico-microbiological examinations the presence of anaerobic flora was found in 104 out of 198 patients with peritonitis. The authors propose using intra-aortal++ transfusions of oxygenated blood in complex therapy of anaerobic peritonitis. PMID:2175490

Zimon, I N; Agzamov, A I; Iskhakova, Kh I; Bazhenov, L G; Anbsalov, M M

1990-06-01

6

Clinico-haematological and mineral studies on experimental maduramicin toxicity in chickens  

Microsoft Academic Search

Clinico-haematological and mineral studies were carried out in experimental chickens given maduramicin medicated feed at 5 and 10ppm for 21 days. Maduramicin medication in both medicated groups caused growth retardation. Clinical signs namely watery diarrhoea, depression, dullness and ruffled feathers were noticed in chickens from second week of the medication at 10ppm but this effect was seen from third week

Tersem Singh; R. P Gupta

2003-01-01

7

Clinico-pathological Features and Outcomes in Chronic Phase Chronic Myeloid Leukemia Patients Treated with Hydroxyurea  

Microsoft Academic Search

Objective: To study the clinico-pathological features and major outcomes in patients with chronic myeloid leukemia, chronic phase, treated with hydroxyurea. Methods: This is a single centre study extending from January 1997 to June 2003. Data were retrieved from the patients' records on predetermined performa and analyzed. Patients were primarily diagnosed on the basis of clinical findings, complete blood counts and

Syed Muhammad Irfan; Yasmin Bhurgri

2009-01-01

8

CLINICO-EPIDEMIOLOGY OF HEPATITIS C VIRAL INFECTION IN NORTHEASTERN THAILAND  

Microsoft Academic Search

Hepatitis C virus (HCV) is responsible for a large number of cases of chronic liver disease worldwide. A study of clinico-epidemiology of HCV infection was conducted in 214 patients who were seropositive for antibody to HCV (anti-HCV) in Srinagarind Hospital , Khon Kaen University, northeastern Thailand, during August 1997 to December 1998. There were 199 males, 15 females and their

Kitti Chunlertrith; Wattana Sukeepaisarnjaroen; Pisaln Mairiang; Yupa Urwijitaroon; Kojiro Takase; Toru Yamauchi; Hitoshi Yoshimura; Yokihiko Tameda

2000-01-01

9

A clinico-pathological study of canine Cushing's disease caused by a pituitary carcinoma.  

PubMed

Knowledge of clinico-pathological correlations in canine Cushing's disease is rather poor. Therefore we describe, clinically and pathologically, a case of pituitary tumour-dependent Cushing's disease in an 8-year old female cocker spaniel. Based on our results, the tumour was defined as a non-dexamethasone-suppressive, corticotrophic adenocarcinoma characterized by some new findings such as intracerebral metastases of anti-ACTH-labelled tumour cells and combined alpha-, beta- and gamma 3-MSH immunoreactivity in the tumour. PMID:1662239

Boujon, C E; Ritz, U; Rossi, G L; Bestetti, G E

1991-10-01

10

Clinico-etiological study of 30 erythroderma cases from tertiary center in South India  

PubMed Central

Background: Erythroderma is a morphological reaction pattern of skin having many underlying causes and finding the etiology helps in the proper management of erythroderma cases. Aim: To evaluate the clinical profile, etiology of erythroderma and to correlate clinical diagnosis with histopathology. Materials and Methods: This study was performed at the department of dermatology, Father Muller Medical College and Hospital, Mangalore, South India. We studied 30 consecutive cases of erythroderma with respect to the epidemiological, clinical and histological data. Clinico-histological correlation was analyzed for etiology of erythroderma. Results: The mean age of onset was 52.3 years with a male to female ratio of 14:1. In addition to erythroderma, other co-existent features included pruritus, fever, lymphadenopathy, and edema. Of the pre-existing dermatoses, psoriasis was the most common (33.3%) disease followed by eczema (20%), atopic dermatitis (6.6%), pityriasis rubra pilaris (3.3%) and drug-induced erythroderma (16.6%). In 16.6% of cases, etiology could not be ascertained. Clinico-histopathological correlation could be established in 73.3% of cases. Conclusion: Clinical features were identical irrespective of etiology. Detailed clinico-histopathological examination helps to establish the etiology of erythroderma. PMID:24616850

Hulmani, Manjunath; NandaKishore, B.; Bhat, M. Ramesh; Sukumar, D.; Martis, Jacintha; Kamath, Ganesh; Srinath, M. K.

2014-01-01

11

[Clinico-epidemiological characteristics of tick-borne encephalitis in the Maritime Territory].  

PubMed

Clinico-epidemiological analysis of tick-borne encephalitis (TBE) incidence rate in the Primorski Territory for 25 years has revealed the prevalence of focal forms of this infection (on the average, 50%) and its high mortality rate (on the average, 33% for the focal forms and 6.4% for the meningeal form). Such course and termination of this infection depend not only on the reactive capacity of the patient's body, but, to a great extent, on the virulence of TBE virus circulating in the area under study. PMID:3445729

Leonova, G N; Rybachuk, V N; Krugliak, S P; Guliaeva, S E; Baranov, N I

1987-12-01

12

Can we overcome the 'clinico-radiological paradox' in multiple sclerosis?  

PubMed

The association between common neuroradiological markers of multiple sclerosis (MS) and clinical disability is weak, a phenomenon known as the clinico-radiological paradox. Here, we investigated to which degree it is possible to predict individual disease profiles from conventional magnetic resonance imaging (MRI) using multivariate analysis algorithms. Specifically, we conducted cross-validated canonical correlation analyses to investigate the predictive information contained in conventional MRI data of 40 MS patients for the following clinical parameters: disease duration, motor disability (9-Hole Peg Test, Timed 25-Foot Walk Test), cognitive dysfunction (Paced Auditory Serial Addition Test), and the expanded disability status scale (EDSS). It turned out that the information in the spatial patterning of MRI data predicted the clinical scores with correlations of up to 0.80 (p < 10(-9)). Maximal predictive information for disease duration was identified in the precuneus and somatosensory cortex. Areas in the precuneus and precentral gyrus were maximally informative for motor disability. Cognitive dysfunction could best be predicted using data from the angular gyrus and superior parietal lobe. For EDSS, the inferior frontal gyrus was maximally informative. In conclusion, conventional MRI is highly predictive of clinical disability in MS when pattern-based algorithms are used for prediction. Thus, the so-called clinico-radiological paradox is not apparent when using suitable analysis techniques. PMID:22446893

Hackmack, Kerstin; Weygandt, Martin; Wuerfel, Jens; Pfueller, Caspar F; Bellmann-Strobl, Judith; Paul, Friedemann; Haynes, John-Dylan

2012-10-01

13

Clinico-hematological and micronuclear changes induced by cypermethrin in broiler chicks: Their attenuation with vitamin E and selenium  

Microsoft Academic Search

This study was carried out on 90 one-day-old broiler chicks to know clinico-hematological alterations, DNA damage caused by cypermethrin (CY), and attenuation of toxic effects by vitamin E (Vit E) and selenium (Se). Birds were randomly divided into five equal groups. Groups 1–4 received CY (600mlkg?1b.wt) daily for 30 days by crop tubing. In addition to CY, groups 2, 3

Summaira Sharaf; Ahrar Khan; Muhammad Zargham Khan; Faiza Aslam; Muhammad Kashif Saleemi; Fazal Mahmood

2010-01-01

14

Demographic and clinico-pathological characteristics in patients with triple-negative and non-triple-negative breast cancer  

Microsoft Academic Search

We investigate retrospectively the demographic and clinico-pathological characteristics of patients with triple-negative breast\\u000a cancer (TNBC) compared to those with non-TNBC. Patients with breast cancer diagnosed from 1981 to 2008 in our clinic were\\u000a retrospectively analyzed. Patient demographics including survival data and tumor characteristics were obtained from charts.\\u000a A total of 795 patients were assessed in the study, including 140 patients

Nilufer Bulut; Sercan Aksoy; Omer Dizdar; Didem S. Dede; Cagatay Arslan; Erkan Dogan; Ibrahim Gullu; Yavuz Ozisik; Kadri Altundag

15

The clinico-pathology and mechanisms of trypanosomosis in captive and free-living wild animals: A review  

Microsoft Academic Search

Reports on the clinico-pathology and mechanisms of trypanosomosis in free-living and captive wild animals showed that clinical\\u000a disease and outbreaks occur more commonly among captive than free-living wild animals. This is because the free-living wild\\u000a animals co-exist with the disease until subjected to captivity. In exceptional cases however, draught, starvation and intercurrent\\u000a diseases often compromised trypanotolerance leading to overt trypanosomosis

A. W. Mbaya; M. M. Aliyu; U. I. Ibrahim

2009-01-01

16

Clinico-haematological and mineral studies on experimental maduramicin toxicity in chickens.  

PubMed

Clinico-haematological and mineral studies were carried out in experimental chickens given maduramicin medicated feed at 5 and 10 ppm for 21 days. Maduramicin medication in both medicated groups caused growth retardation. Clinical signs namely watery diarrhoea, depression, dullness and ruffled feathers were noticed in chickens from second week of the medication at 10 ppm but this effect was seen from third week in the birds given maduramicin at 5 ppm. Maduramicin medication caused significant reduction in haemoglobin in both the medicated group from day 14 and total erythrocyte count and packed cell volume in 10 ppm group on day 21. There was an increase in MCV in 10 ppm group on day 21 indicating macrocytic anaemia and decrease in mean corpuscular haemoglobin concentration (MCHC) in both the medicated groups indicating hypochromic anaemia. The leucopenia due to lymphopenia was observed in 10 ppm group on day 21. Maduramicin medication caused significant increase in serum Zn in 10 ppm group and decrease in Cu concentration in both the medicated groups from day 14. It is concluded that maduramicin caused toxic effects from day 14 in both the medicated groups. PMID:14580805

Singh, Tersem; Gupta, R P

2003-10-30

17

Trifurcation of superficial brachial artery: a rare case with its clinico-embryological implications.  

PubMed

Literatures on vasculature of upper limbs are crammed with reports of distinctly deviant version of normally prevalent vessels having modified origins, altered branching and odd courses. A unique anatomical variation in vascular pattern was observed during routine dissection of right upper limb in gross anatomy laboratory, AIIMS, New Delhi, India. The brachial artery was placed superficial to median nerve in the arm and therefore it was called superficial brachial artery. In the cubital fossa, 2.8 cm distal to intercondylar line of elbow joint, this superficial brachial artery terminated by trifurcation into radial, common interosseous and ulnar branches. Strikingly the ulnar branch, after its origin ran superficially over the median nerve and epitrochlear superficial flexor group of muscles of forearm in succession for the initial third of its course in the forearm, consequently it was addressed as superficial ulnar artery. The existence of superficial brachial artery in place of normal brachial artery, its termination by trifurcation into radial, common interosseous and superficial ulnar arteries with remarkably different courses, leads to confusing disposition of structures in the arm, cubital fossa and in the forearm and collectively makes this myriad of anatomical variations even rarer. The clinico-embryological revelations for combination of these unconventional observations, apprises and guides the specialized medical personnel attempting blind and invasive procedures in brachium and ante-brachium. This case report depicts the anatomical perspective and clinical implications on confronting a rare variant vasculature architecture pattern of upper limb. PMID:25366943

Gupta, N; Anshu, A; Dada, R

2014-01-01

18

Human Cystic Echinococcosis in the Nalut District of Western Libya: A Clinico-epidemiological Study  

PubMed Central

Human cystic echinococcosis (CE) is an endemic disease in the Mediterranean area that has not yet been fully documented in western Libya. The present study describes the clinico-epidemiologic profile of CE in western Libya’s Nalut district. From April 2008 to July 2011, 36 cases of CE were confirmed following surgical removal of cysts. The cysts were most frequently found in the liver (61.1%), followed by the lungs (19.4%), kidneys (11.1%), peritoneal cavity (11.1%), and spleen (5.6%). Among the 36 patients, 6 possessed plural cysts and 3 had cysts in 2 organs. Blood samples from this group were examined for the presence of serum anti-hydatid IgG antibodies, which revealed positivity in 25 patients (69.4%). An additional 300 blood samples were collected randomly from the inpatient and outpatient clinics at Nalut Hospital. Twenty-seven samples (9%) were found to be positive for the anti-hydatid IgG antibody among which the prevalence of infection tended to be higher in men (12%) than in women (6%). This study demonstrates that CE is a major parasitic infectious disease of public health significance in Libya, notably in the western part of the country, and that disease awareness needs to be raised nationwide.

Mohamed, Rabie M.; Abdel-Hafeez, Ekhlas H.; Belal, Usama S.; Norose, Kazumi; Aosai, Fumie

2014-01-01

19

Clinico-biological characteristics and treatment of type I monoclonal cryoglobulinaemia: a study of 64 cases.  

PubMed

This retrospective analysis was conducted in 64 patients diagnosed with type I cryoglobulinaemia (CG) followed at two French centres. Median follow-up was 6·75 years. CG was IgG in 60% and IgM in 40% of all cases and was asymptomatic in 16 patients (25%). Cold-triggered ischaemic skin manifestations were observed in 33 patients (51%). Neurological manifestations were observed in 15 patients and renal manifestations in 13. Most of the patients with necrotic purpura (14/16, P = 0·009) and renal manifestations (11/13, P = 0·057) had IgG CG. IgG CG was associated with monoclonal gammopathy of undetermined significance (MGUS), myeloma, chronic lymphocytic leukaemia and lymphoplasmocytic lymphoma in 18, 13, 5 and 2 patients, respectively. IgM CG was associated with MGUS and Waldenström macroglobulinaemia in 8 and 18 cases, respectively. One third of patients did not receive any specific treatment. Various treatments, including rituximab, were administered to 25/31 patients with IgG CG and 6/25 patients with IgM CG due to CG-related symptoms. Rituximab was ineffective in all cases associated with a predominantly plasmacytic proliferation. To conclude, type I CG has specific clinico-biological characteristics compared to type II CG. Furthermore, there are differences in terms of related manifestations between type I IgG and type I IgM CG. PMID:25363150

Harel, Stephanie; Mohr, Melanie; Jahn, Isabelle; Aucouturier, Francoise; Galicier, Lionel; Asli, Bouchra; Malphettes, Marion; Szalat, Raphael; Brouet, Jean-Claude; Lipsker, Dan; Fermand, Jean-Paul

2014-11-01

20

Application of Clinico-Radiologic-Pathologic Diagnosis of Diffuse Parenchymal Lung Diseases in Children in China  

PubMed Central

Diffuse parenchymal lung diseases in children (chDPLD) or interstitial lung diseases in children (chILD) represent a heterogeneous group of respiratory disorders that are mostly chronic and associated with high morbidity and mortality. However, the incidence of chDPLD is so low that most pediatricians lack sufficient knowledge of chDPLD, especially in China. Based on the clinico- radiologic- pathologic (CRP) diagnosis, we tried to describe (1) the characteristics of chDPLD and (2) the ratio of each constituent of chDPLD in China. Data were evaluated, including clinical, radiographic, and pathologic results from lung biopsies. We collected 25 cases of chDPLD, 18 boys and 7 girls with a median age of 6.0 years, from 16 hospitals in China. The most common manifestations included cough (n = 24), dyspnea (n = 21), and fever (n = 4). There were three cases of exposure-related interstitial lung disease (ILD), three cases of systemic disease-associated ILD, nineteen cases of alveolar structure disorder-associated ILD, and no cases of ILD specific to infancy. Non-specific interstitial pneumonia (n = 9) was the two largest groups. Conclusion: Non-specific interstitial pneumonia is the main categories of chDPLD in China. Lung biopsy is always a crucial step in the final diagnosis. However, clinical and imaging studies should be carefully evaluated for their value in indicating a specific chDPLD. PMID:25569558

Xu, Dan; Chen, Zhimin; Chen, Huizhong; Huang, Rongyan; Zhao, Shunying; Liu, Xiuyun; Zhou, Chunju; Peng, Yun; Yuan, Xinyu; Zou, Jizhen; Zhang, Hailing; Zhao, Deyu; Liu, Enmei; Zheng, Yuejie; Zhong, Lili; Lu, Min; Lu, Jirong; Nong, Guangmin

2015-01-01

21

Clinico-pathological study of a case of familial parkinsonism with striatal degeneration.  

PubMed

The clinico-pathological study of a new type of familial parkinsonism with striatal degeneration is reported. The inheritance mode was autosomal recessive, and three out of four offspring of married cousins developed parkinsonism in their early adulthood. Their clinical signs were rigidity, bradykinesia, postural instability and dysarthria. These symptoms were slowly progressive and responsive to levodopa therapy to a variable degree. On cerebral magnetic resonance imaging, T2 and proton density-weighted images showed hyperintensity in the bilateral putamina. The neuropathological study of one case revealed atrophy of the bilateral putamina and caudate nuclei, and a severe neuronal loss and gliosis in the putamina. Patchy mosaicism of normal and degenerated tissue was observed in the putamina. A similar mode of the degeneration was mildly seen in the caudate nuclei. The substantia nigra showed atrophy of the pars reticulata, and mild to moderate neuronal loss of the pars compacta with rostral dominance, but no Lewy bodies were observed. These neuropathological findings differed from those of Parkinson's disease or juvenile parkinsonism, but mimic to those of X-linked dystonia parkinsonism (Lubag). It seems that this familial bilateral striatal degeneration is a new variant of familial parkinsonism. PMID:12471465

Sakai, Motoko; Konagaya, Masaaki; Kuru, Satoshi; Kato, Takashi; Matsuoka, Yukihiko; Hashizume, Yoshio

2003-01-01

22

Human Cystic Echinococcosis in the Nalut District of Western Libya: A Clinico-epidemiological Study.  

PubMed

Human cystic echinococcosis (CE) is an endemic disease in the Mediterranean area that has not yet been fully documented in western Libya. The present study describes the clinico-epidemiologic profile of CE in western Libya's Nalut district. From April 2008 to July 2011, 36 cases of CE were confirmed following surgical removal of cysts. The cysts were most frequently found in the liver (61.1%), followed by the lungs (19.4%), kidneys (11.1%), peritoneal cavity (11.1%), and spleen (5.6%). Among the 36 patients, 6 possessed plural cysts and 3 had cysts in 2 organs. Blood samples from this group were examined for the presence of serum anti-hydatid IgG antibodies, which revealed positivity in 25 patients (69.4%). An additional 300 blood samples were collected randomly from the inpatient and outpatient clinics at Nalut Hospital. Twenty-seven samples (9%) were found to be positive for the anti-hydatid IgG antibody among which the prevalence of infection tended to be higher in men (12%) than in women (6%). This study demonstrates that CE is a major parasitic infectious disease of public health significance in Libya, notably in the western part of the country, and that disease awareness needs to be raised nationwide. PMID:25589882

Mohamed, Rabie M; Abdel-Hafeez, Ekhlas H; Belal, Usama S; Norose, Kazumi; Aosai, Fumie

2014-12-01

23

Evaluation of clinico-pathological features and Helicobacter pylori infection in gastric inflammatory fibroid polyps.  

PubMed

Inflammatory fibroid polyps are rare mesenchymal lesions. The frequency of Helicobacter pylori infection in the gastric mucosa overlying inflammatory fibroid polyps and its relation with the histologic features of the polyps are undetermined. The clinico-pathological features of inflammatory fibroid polyps, the frequency of Helicobacter pylori infection in the overlying gastric mucosa, and its putative impact on the phenotype of the polyps were evaluated. Gastric inflammatory fibroid polyps diagnosed in our Hospital from 1998 to 2012 were reviewed and the histological. The histological sections were stained with hematoxylin and eosin and modified Giemsa for the evaluation of Helicobacter pylori infection. Inconclusive cases were further analyzed by immunohistochemistry with anti-Helicobacter pylori antibody. Diagnosis was confirmed in 54 polyps, 85 % developed in females, mean age 63?±?11 years. Most polyps were sessile (74 %), with a mean size of 15?±?12 mm, 96 % were located in the antrum and 85 % were removed by snare polypectomy. Helicobacter pylori infection was identified in 48 % of the polyps. Most inflammatory fibroid polyps developed in the submucosa, and mucosal extension was observed in 96 % of the cases. Chronic gastritis was observed in all cases (63 % with activity, 31 % with intestinal metaplasia, and 61 % with foveolar hyperplasia). Erosion and ulceration of the overlying gastric mucosa was observed in 48 % and 11 % of the polyps, respectively. Onion skin features were present in 52 % of the polyps and were more frequently observed in cases without evidence of Helicobacter pylori infection. Background changes in gastric mucosa were not distinctive according to Helicobacter pylori infection. Chronic atrophic gastritis with intestinal metaplasia was associated with the presence of perivascular onion skin lesions. To our knowledge, this is the second largest series of gastric inflammatory fibroid polyps. Helicobacter pylori infection was identified in about half of the cases and was associated with a lower frequency of onion skin features in the polyps. PMID:25257403

Albuquerque, Andreia; Rios, Elisabete; Carneiro, Fátima; Macedo, Guilherme

2014-12-01

24

Clinico-radiological Characteristics of Spontaneous Basal Ganglia Hemorrhage, According to Regional Classification  

PubMed Central

Objective The clinico-radiologic features of the spontaneous basal ganglia hemorrhage (BGH) may often differ one from another, according to its regional location. Therefore, we attempted to classify the BGH into regional subgroups, and to extrapolate the distinct characteristics of each group of BGH. Materials and Methods A total of 103 BGHs were analyzed by retrospective review of medical records. BGH was classified according to four subgroups; anterior BGH; posterior BGH; lateral BGH; massive BGH. Results The most common BGH was the posterior BGH (56, 54.4%), followed by the lateral BGH (26, 25.2%), the massive BGH (12, 11.7%), and the anterior BGH (9, 8.7%). The shape of hemorrhage tended to be round in anterior, irregular in posterior, and ovoid in lateral BGH. A layered density of hematoma on initial computed tomography showed correlation with hematoma expansion (p = 0.016), which was observed more often in the postero-lateral group of BGH than in the anterior BGH group. Relatively better recovery from the initial insult was observed in the lateral BGH group than in the other regional BGH groups. The proportion of poor outcome (modified Rankin scale 4, 5, 6) was 100% in the massive, 41.1% in the posterior, 34.6% in the lateral, and 0% in the anterior BGH group. Conclusion We observed that BGH can be grouped according to its regional location and each group may have distinct characteristics. Thus, a more sophisticated clinical strategy tailored to each group of BGHs can be implemented. PMID:25340023

Kim, Do Young; Choo, Yeon Soo; Jang, E Wook; Chung, Joonho; Joo, Jin Yang

2014-01-01

25

[A comparative clinico-economic study of 2 models of organizational forms of psychiatric care exemplified in schizophrenia].  

PubMed

The authors describe part of the results of a comparative clinico-economic analysis of the functioning of two models of organizational forms of psychiatric services with special reference to Moscow and Kaluga. The purpose of the given research fragment was to make a comparative analysis of expenditures on schizophrenic patients depending on the system of psychiatric services organization on the whole and between different types of services; to specify approaches to optimization of their functioning with the use of a clinico-economic approach. Based on a comparative investigation of the representative groups of schizophrenic patients (386 patients of a mental health center in Moscow and 531 patients of the Kaluga regional psychiatric hospital No. 1), it has been established that as a result of the proper organization and financing of psychiatric services in Kaluga, the "direct" expenditures on one schizophrenic patient per year could be 20% as reduced and the losses of the national income could be lowered more than 2-fold. It should necessarily be mentioned that the financing of extra hospital services in Kaluga exceeded that in Moscow more than 3-fold, reaching about 20.3% of all the expenditures on schizophrenic patients. Apparently, the organizational and financial experience gained in Kaluga with the design of the common complex and many-staged system of psychiatric services may turn fairly instrumental in elaborating approaches to optimization of the functioning of psychiatric services. PMID:1332339

Ushakov, Iu V; Bogdanova, E D; Shipin, S V; Mirzoian, M G

1992-01-01

26

Parasitological and clinico-epidemiological features of onchocerciasis in West Wellega, Ethiopia.  

PubMed

Onchocerciasis is a disease of public health and socio-economic importance in Ethiopia. The aim of this study was to assess parasitological and clinico-epidemiological features of onchocerciasis in the Anfilo District, West Wellega, prior to implementation of Community Directed Treatment with Ivermectin (CDTI) to generate epidemiological and parasitological data for use in control program of the disease and subsequent evaluation of CDTI. A cross-sectional study was conducted in Anfilo District of West Wellega zone during a period of 1 month: from mid-August to mid-September 2006. Data on socio-demographic characteristics were collected using a standardized questionnaire prepared for this purpose. All persons were examined clinically for skin signs and symptoms of onchocerciasis. Two skin snips, one from each side of the gluteal fold were taken using blood lancet and sterilized razor blade and examined for microfilaria. All data were categorized, coded, entered in a data base and analyzed using SPSS version 15.0. for windows. A total of 1114 individuals ?15 years were examined for microfilariae (mf) of Onchocerca volvulus and onchocercal skin disease (OSD). The prevalence of onchocercal (mf) carrier was 74.8% (833/1114). In both genders, the prevalence of onchocerciasis showed direct correlations with the age of individuals (R (2) = 0.79, P < 0.05). The infection rate varied with the occupation of the study subjects, with preponderance among farmers. Among the subjects with onchocerciasis, the mf density ranged from 1.0 to 711.0 per mg of skin snip with a mean density (SD) and median values of 32.1 (61.5) and 10.4 respectively. The overall community microfilariae load (CMFL), the most sensitive parasitological indicator of onchocerciasis was 19.6. The pervasiveness of OSD among the study subjects was 26.4%. OSD was more frequent in males (32.4%) than their female counterparts (20.8%, P < 0.05). The overall prevalence of onchocercal nodule carrier, the symptom opted for determining the community-wide prevalence of onchocerciasis was 12.1%. Leopard skin, the proxy of longstanding infection of onchocerciasis in the community, was also relatively high (19.1%). The abundance of mf in skin would definitely lead to high transmission potential in the Anfilo District. The situation in the Anfilo District should call for continued CDTI, owing to success of similar recommendations for such programmes in other parts of the country and elsewhere. PMID:23542576

Dori, Geme Urge; Belay, Tariku; Belete, Habtamu; Panicker, K N; Hailu, Asrat

2012-04-01

27

Louse-borne relapsing fever in the Sudan. A historical review and a clinico-pathological study.  

PubMed

A small outbreak of louse-borne relapsing fever in Khartoum (May-June 1974) provided material for a clinico-pathological study. The history of the disease in the Sudan is reviewed and the clinical and laboratory findings in 32 patients are presented. Fever, headache, jaundice, epistaxis and hepatosplenomegaly were the commonest clinical findings; thrombocytopenia was detected in 93% of cases. Although elevated levels of fibrin degradation products were found in most patients, disseminated intravascular coagulation could not be diagnosed. Hepatocellular derangement was found in 68% of cases, while 78% had high blood urea. In five autopsied bodies there was bronchopneumonia, interstitial edema with focal myocardial fibrosis, hepatic necrosis, splenic infarcts, increase in size and cellularity of the glomeruli and brain edema and congestion. Intracranial haemorrhage was found in three of the autopsied cases. PMID:7423600

Ahmed, M A; Abdel Wahab, S M; Abdel Malik, M O; Abdel Gadir, A M; Salih, S Y; Omer, A; Al Hassan, A M

1980-06-01

28

[The comparative results of a clinico-economic and socioeconomic study of 2 populations of schizophrenic patients under different organizational forms of psychiatric care].  

PubMed

The paper is a fragment of a comparative clinico-economic study of two models of organizational forms of psychiatric services in Moscow and Kaluga with special reference to schizophrenic patients (386 and 531 patients, respectively). The authors describe the results of computing expenditures on patients depending on the sex, age, disease pattern and social factors including educational and skill levels, family status, and family structure. The values of "direct" and "indirect" expenditures on schizophrenic patients are fairly variable. There are definite significant relationships between the magnitude of these expenditures and clinico-psychopathological and social factors as is their certain stability in both patients' populations examined. The adequately designed psychiatric services, scientifically based financing of the appropriate treatment and social rehabilitation programs may have a noticeable effect on the magnitude and character of losses on the part of the state, connected with schizophrenic patients, decrease expenditures on them as well as markedly improve their social functioning. PMID:1332340

Ushakov, Iu V; Bogdanova, E D; Shipin, S V; Mirzoian, M G

1992-01-01

29

Determination of prognosis in metastatic melanoma through integration of clinico-pathologic, mutation, mRNA, microRNA, and protein information.  

PubMed

In patients with metastatic melanoma, the identification and validation of accurate prognostic biomarkers will assist rational treatment planning. Studies based on "-omics" technologies have focussed on a single high-throughput data type such as gene or microRNA transcripts. Occasionally, these features have been evaluated in conjunction with limited clinico-pathologic data. With the increased availability of multiple data types, there is a pressing need to tease apart which of these sources contain the most valuable prognostic information. We evaluated and integrated several data types derived from the same tumor specimens in AJCC stage III melanoma patients-gene, protein, and microRNA expression as well as clinical, pathologic and mutation information-to determine their relative impact on prognosis. We used classification frameworks based on pre-validation and bootstrap multiple imputation to compare the prognostic power of each data source, both individually as well as integratively. We found that the prognostic utility of clinico-pathologic information was not out-performed by any of the various "-omics" platforms. Rather, a combination of clinico-pathologic variables and mRNA expression data performed best. Furthermore, a patient-based classification analysis revealed that the prognostic accuracy of various data types was not the same for different patients. This indicates that ongoing development in the individualized evaluation of melanoma patients must take account of the value of both traditional and novel "-omics" measurements. PMID:24975271

Jayawardana, Kaushala; Schramm, Sarah-Jane; Haydu, Lauren; Thompson, John F; Scolyer, Richard A; Mann, Graham J; Müller, Samuel; Yang, Jean Yee Hwa

2015-02-15

30

PAH exposure biomarkers are associated with clinico-chemical changes in the brick kiln workers in Pakistan.  

PubMed

In this study we investigated the clinico-chemical parameters and the level of exposure of brick kiln workers to polycyclic aromatic hydrocarbons (PAHs) in Punjab (Pakistan). The brick kiln workers and a non-occupationally exposed group were recruited for comparative analysis of urinary biomarkers of PAH exposure (i.e. 1-hydroxypyrene (1-OHPyr), ?-naphthol and ?-naphthol) and blood level of superoxide dismutase (SOD), as a biomarker of oxidative stress and other hematologic parameters. Questionnaires were used to document information on socio-demographic characteristics of all the subjects. The analysis of urinary biomarkers showed higher median concentrations of 1-OHPyr, and ?- and ?-naphthols in brick kiln workers (1.53, 3.65 and 1.53 ?mol/mol-Cr, respectively) than non-occupationally exposed group (0.62, 0.64 and 0.66 ?mol/mol-Cr, respectively). The 1-OHPyr in brick kiln workers was above the occupational exposure level. Among the clinical parameters of brick kiln workers, hemoglobin (Hb) and red blood cells (RBCs) were very low and closely associate with 1-OHPyr and ?-naphthol. Additionally, the white blood cells (WBCs) and superoxide dismutase (SOD) were also elevated in brick kiln workers, which suggested inflammatory symptoms and high oxidative stress. The results show that regardless of possibly being affected by the poor nutrition, the anemic state and hematological changes observed in brick kiln workers may be associated with their exposure to smoke present in the environment of brick kilns. PMID:24878696

Kamal, Atif; Malik, Riffat Naseem; Martellini, Tania; Cincinelli, Alessandra

2014-08-15

31

Clinico-hematological and micronuclear changes induced by cypermethrin in broiler chicks: Their attenuation with vitamin E and selenium.  

PubMed

This study was carried out on 90 one-day-old broiler chicks to know clinico-hematological alterations, DNA damage caused by cypermethrin (CY), and attenuation of toxic effects by vitamin E (Vit E) and selenium (Se). Birds were randomly divided into five equal groups. Groups 1-4 received CY (600mlkg(-1)b.wt) daily for 30 days by crop tubing. In addition to CY, groups 2, 3 and 4 received Vit E (150mgkg(-1)b.wt), Se (0.25mgkg(-1)b.wt), and Vit E (150mgkg(-1)b.wt)+Se (0.25mgkg(-1)b.wt), respectively. Group 5 served as control. Birds were monitored twice daily for clinical signs. They were weighed and blood samples were collected at experimental days 10, 20 and 30 for hematological studies. CY-treated birds showed more prominent signs of toxicity compared to CY+Vit E, CY+Se and CY+Vit E+Se birds. Body weight in groups 1-3 was significantly (P<0.05) smaller at days 20 and 30 when compared with the control group. Significantly (P<0.001) higher numbers of micronuclei appeared in chicks treated with CY compared to CY+Vit E- and CY+Se-treated birds. Significantly decreased total erythrocyte counts (TEC), hemoglobin (Hb) concentration and packed cell volume (PCV) in all treated groups were recorded. Treated birds suffered from macrocytic hypochromic anemia. Leukocytosis in early stage and later leucopenia was seen in treated birds. It can be concluded that CY induces toxic effects in broilers chicks; however, these toxic effects can be ameliorated by Vit E or Se. Combination of Vit E and Se was more effective to ameliorate toxic effects of cypermethrin. PMID:19520556

Sharaf, Summaira; Khan, Ahrar; Khan, Muhammad Zargham; Aslam, Faiza; Saleemi, Muhammad Kashif; Mahmood, Fazal

2010-07-01

32

Clinico-immunologic evaluation of allergy to Himalayan tree pollen in atopic subjects in India--a new record.  

PubMed

Exposure to local pollen allergens has a direct bearing on the prevalence of allergic symptoms among the inhabiting atopic population. The populations in the Himalayas and around it are exposed to a variety of pollen grains from trees growing in the region, but the pollen-population interaction has not been clinically investigated. Himalayan tree pollen from five different taxa, i.e. Alnus nitida (AN), Betula utilis (BU), Cedrus deodara (CD), Mallotus phillipensis (MP) and Quercus incana (QI) were evaluated for their allergenicity in the Indian population by in vivo (skin prick test) and in vitro (ELISA) clinico-immunological methods. The presence of specific IgE against these tree pollen in the sera of skin test positive patients was taken as evidence for sensitization to these pollen. The average skin positivity in atopic populations recorded at different allergy centers in India varied from 2.2% against AN, to 4.7% against MP pollen. Significantly raised specific IgE against these pollen were observed in the sera of hypersensitive patients. The sensitization pattern to Himalayan tree pollen in these atopic populations varied. It was concluded that skin prick test positivity and raised IgE antibodies specific to AN, BU, CD, MP and QI established Himalayan tree pollen as important sensitizers in the atopic populations of India. A high incidence of skin sensitivity was observed to pollen antigens of Cedrus deodara, Mallotus phillipensis and Quercus incana in patients of Chandigarh residing in the hills and foothills of the Himalayas while Alnus nitida, Betula utilis and Cedrus deodara were important sensitizers in Delhi patients. The skin sensitization pattern against these pollen was in accordance with the level of exposure to these pollen of the subjects residing in that part of the country. PMID:16252835

Bist, Arnima; Kumar, Lata; Roy, Indrani; Ravindran, P; Gaurs, S N; Singh, A B

2005-01-01

33

Influenza del microscopio operatorio nella diagnosi intraoperatoria e nel ritrattamento chirurgico endodontico: studio clinico e radiografico con follow-up a un anno  

Microsoft Academic Search

ObjectivesThe aim of the present study was to assess under the operative microscope the causes of the failure of previous apicoectomies and to evaluate the clinical and radiographic outcome of surgical endodontic retreatment after 1 year.

M. Rapani; G. E. Pecora; C. N. Pecora; G. di Gregorio; A. Piattelli; L. Ricci

2011-01-01

34

Evolution of Charcot-Marie-Tooth disease type 1A duplication: a 2-year clinico-electrophysiological and lower-limb muscle MRI longitudinal study.  

PubMed

The objective of this study was to analyze Charcot-Marie-Tooth disease type 1A (CMT1A) evolution. We conducted a 2-year longitudinal study in 14 CMT1A patients and 14 age- and sex-matched controls. In the patients, we performed neurological examination with hand-held dynamometry, electrophysiology, and lower-limb muscle MRI, both at baseline and 2 years later, while controls were examined at baseline only. Patients' ages ranged from 12 to 51 years. Outstanding manifestations on initial evaluation included pes cavus, areflexia, lower-limb weakness, and foot hypopallesthesia. In evaluating muscle power, good correlation was observed between manual testing and dynamometry. Compared to controls, Lunge, 10-Meter-Walking, and 9-Hole-Peg tests were impaired. Their CMT neuropathy score and functional disability scale showed that patients exhibited mild phenotype and at most slight walking difficulty. Electrophysiology revealed marked nerve conduction slowing and variable compound muscle action potential amplitude reduction. On lower-limb muscle MRI, there was distally accentuated fatty infiltration accompanied by edema in calf muscles. All these clinico-electrophysiological and imaging findings remained almost unaltered during monitoring. Using multivariate analysis, no significant predictors of progression associated to the disease were obtained. We conclude that in the 2-year period of study, CMT1A patients showed mild progression with good concordance between clinico-electrophysiological and imaging findings. PMID:24449066

Pelayo-Negro, Ana L; Gallardo, Elena; García, Antonio; Sánchez-Juan, Pascual; Infante, Jon; Berciano, José

2014-04-01

35

Chronic lymphocytic leukemia in the elderly: clinico-biological features, outcomes, and proposal of a prognostic model  

PubMed Central

We investigated the clinico-biological features, outcomes, and prognosis of 949 patients with chronic lymphocytic leukemia according to age. No biological differences (cytogenetics by fluorescent in situ hybridization, IGHV, ZAP-70, CD38, NOTCH1, SF3B1) were found across age groups. Elderly patients (>70 years; n=367) presented more frequently with advanced disease (Binet C/Rai III-IV: 10/12% versus 5/5%; P<0.001), were treated less frequently (23.8% versus 41.9% at 3 years; P<0.001) and in most cases did not receive highly effective regimens and thus had a lower overall response rate (49% with 14% having complete responses versus 69% with 31% having complete responses; P<0.001). The elderly patients also had a shorter overall survival (6.6 versus 13.3 years; P<0.001) and higher disease-unrelated mortality (34.9% versus 6.9% at 10 years; P<0.001). However, disease-attributable mortality was not significantly different between younger and older patients. A combination of Binet stage, ZAP-70 level, ?2-microglobulin concentration and comorbidity identified two risk groups (low-risk: 0–1 parameters; high-risk: 2–4 parameters) with different overall survivals (median: 6.8 versus 11.4 years, P<0.001). In patients requiring treatment, comorbidity at treatment (Cumulative Illness Rating Scale-T>4; hazard ratio 2.2, P<0.001) and response (treatment failure versus response: hazard ratio 1.60, P<0.04) were the most important prognostic factors for overall survival. In conclusion, in our series, elderly patients with chronic lymphocytic leukemia did not present with any biological features distinct from those of younger patients, but did have a poorer clinical outcome. This study highlights the importance of comprehensive medical care, achieving response to therapy, and specific management strategies for elderly patients with chronic lymphocytic leukemia. PMID:24972773

Baumann, Tycho; Delgado, Julio; Santacruz, Rodrigo; Martínez-Trillos, Alejandra; Royo, Cristina; Navarro, Alba; Pinyol, Magda; Rozman, María; Pereira, Arturo; Villamor, Neus; Aymerich, Marta; López, Cristina; Carrió, Anna; Montserrat, Emili

2014-01-01

36

MICrocephaly, disproportionate pontine and cerebellar hypoplasia syndrome: A clinico-radiologic phenotype linked to calcium/calmodulin-dependent serine protein kinase gene mutation  

PubMed Central

MICrocephaly, disproportionate pontine and cerebellar hypoplasia (MICPCH) syndrome, a rare X-linked disorder, generally seen in girls, is characterized by neurodevelopmental delay, microcephaly, and disproportionate pontine and cerebellar hypoplasia. It is caused by inactivating calcium/calmodulin-dependent serine protein kinase (CASK) gene mutations. We report a 2-year-old girl with severe neurodevelopmental delay, microcephaly, minimal pontine hypoplasia, cerebellar hypoplasia, and normal looking corpus callosum, with whom the conventional cytogenetic studies turned out to be normal, and an array-comparative genomic hybridization (a-CGH) analysis showed CASK gene duplication at Xp11.4. Our case highlights the importance of using clinico-radiologic phenotype to guide genetic investigation and it also confirms the role of a-CGH analysis in establishing the genetic diagnosis of MICPCH syndrome, when conventional cytogenetic studies are inconclusive. PMID:23901204

Saleem, Rashid; Setty, Gururaj; Hussain, Nahin

2013-01-01

37

The clinico-pathological spectrum of Focal Cortical Dysplasias: a consensus classification proposed by an ad hoc Task Force of the ILAE Diagnostic Methods Commission  

PubMed Central

Focal cortical dysplasias (FCDs) are localized regions of malformed cerebral cortex and are very frequently associated with epilepsy in both children and adults. A broad spectrum of histopathology has been included in the diagnosis of FCD. Characteristic findings include aberrant radial or tangential lamination of the neocortex (FCD Type I) and cytological abnormalities (FCD Type II). An ILAE task force has re-evaluated available data and proposes a clinico-pathologic classification system of FCDs. The major change since a prior classification represents the introduction of FCD Type III, which occurs in combination with Hippocampal Sclerosis (FCD Type IIIa), or with epilepsy-associated tumors (FCD Type IIIb). FCD Type IIIc is found adjacent to vascular malformations, whereas FCD Type IIId can be diagnosed in association with epileptogenic lesions acquired in early life (i.e., traumatic injury, ischemic injury or encephalitis). Hence, FCD Type I will now refer to isolated lesions, which present either as radial (FCD Type Ia) or tangential (FCD Type Ib) dyslamination of the neocortex, microscopically identified in one or multiple lobes. FCD Type II is an isolated lesion characterized by cortical dyslamination and dysmorphic neurons without (Type IIa) or with balloon cells (Type IIb). Architectural abnormalities adjacent to or within gross malformations of cortical development are frequently observed and not distinguished as a specific FCD variant. This three-tiered classification system will help to better characterize specific clinico-pathological entities and is an important basis to further explore imaging, electro-clinical features, and postsurgical seizure control as well as underlying molecular pathomechanisms. PMID:21219302

Blümcke, Ingmar; Thom, Maria; Aronica, Eleonora; Armstrong, Dawna D.; Vinters, Harry V.; Palmini, Andre; Jacques, Thomas S; Avanzini, Giuliano; Barkovich, A. James; Battaglia, Giorgio; Becker, Albert; Cepeda, Carlos; Cendes, Fernando; Colombo, Nadia; Crino, Peter; Cross, J. Helen; Delalande, Olivier; Dubeau, François; Duncan, John; Guerrini, Renzo; Kahane, Philippe; Mathern, Gary; Najm, Imad; Özkara, Çi?dem; Raybaud, Charles; Represa, Alfonso; Roper, Steven N.; Salamon, Noriko; Schulze-Bonhage, Andreas; Tassi, Laura; Vezzani, Annamaria; Spreafico, Roberto

2010-01-01

38

Conversación con Ricardo Monti  

E-print Network

las carreras sucedía lo siguiente: yo quería ser e iba a ser escritor. Empecé filosofía y cursé seis o siete materias. Luego inicié la carrera de psi cología, pero mis estudios de psicología se interrumpieron cuando estrené mi primera obra de teatro... caos, organizar una serie de sensaciones e ideas, que impliquen cierta forma, cierta organización. Además, cada obra mía se empalma con la otra, como si yo buscara obscuramente no solamente organizar ese caos en cada obra, sino ir organizándolo con...

Driskell, Charles B.

1979-04-01

39

Clinico-Histopathological Analysis of Neoplastic and Non-Neoplastic Lesions of the Ovary: A 3-Year Prospective Study in Dhule, North Maharashtra, India  

PubMed Central

Background: Ovary is the commonest site of neoplastic and non-neoplastic lesion, can present in childhood to postmenopausal age group and accounts for the most prevalent cause of hospital admissions. Aim: This study was done to analyse the frequency of ovarian lesions their clinico-histological features in a rural set up. Materials and Methods: This is a prospective study of 145 ovarian lesions at tertiary care hospital over a period of 3yr. All the relevant clinical data of patients analysed from hospital record file. Results: The total number of ovarian lesions studied during study period was 145 cases, amongst them 75 were non-neoplastic and remaining 70 were neoplastic. The most common non-neoplastic lesion seen was solitary follicular cysts i.e. 56 cases (74.66%), followed by corpus luteal cysts 15 cases (20%). Among the 70 neoplastic ovarian lesions 55(78.57%) cases were benign, 1(1.42%) case was at borderline and 14 (20%) cases were malignant. In benign ovarian neoplasm, most commonly seen lesion were serous cystadenoma followed by benign cystic teratoma. In malignant cases, maximum were of serous cystadenocarcinoma, followed by mucinous cystadenocarcinoma and metastatic tumours. Conclusion: Ovarian lesion possess wide gamut of histology. Specific diagnoses are made on routine gross and histological examination or in certain difficult cases require immunohistochemistry. PMID:25302198

N.V., Dravid; P.N., Deore; D.B., Nikumbh; K.H., Suryawanshi

2014-01-01

40

Surgical treatment of lateral clavicle fractures associated with complete coracoclavicular ligament disruption: Clinico-radiological outcomes of acromioclavicular joint sparing and spanning implants  

PubMed Central

Purpose: Distal clavicle fracture associated with complete coracoclavicular ligament disruption represents an unstable injury, and osteosynthesis is recommended. This study was performed (1) to retrospectively analyse the clinico-radiological outcomes of two internal fixation techniques, and (2) to identify and analyse radiographic fracture patterns of fracture that are associated with this injury. Materials and Methods: A total of 15 patients underwent osteosynthesis with either (1) acromioclavicular joint-spanning implants (Group 1, Hook plate device, n = 10) or (2) joint-sparing implants (Group 2, distal radius plate, n = 5); these were reviewed at a mean period of 26.1 months (12 to 40 months). Clinical outcomes were measured using Constant Score (CS), Simple Shoulder Test (SST), and Walch ACJ score (WS). Radiographs and ultrasonography were used to assess the glenohumeral and acromioclavicular joints, and the subacromial space. Preoperative radiographs were analyzed for assessment of fracture lines to identify radiographic patterns. Statistical analysis of the data was performed to determine any significant differences between the two groups. Results: The overall clinical outcome was satisfactory (CS 80.8, SST 11.3, WS 17.6) and a high union rate (93.3%) was observed. Radiographic complications (acromioclavicular degeneration and subluxation, hook migration, abnormal ossification) did not negatively influence the final clinical outcomes. Four distinct radiographic fracture patterns were observed. A statistically significant difference ( P < 0.05) was observed in the reoperation rates between the two groups. Conclusions: Internal fixation of this fracture pattern is associated with a high union rate and favorable clinical outcomes with both techniques. A combination of distal radius plate and ligament reconstruction device resulted in stable fixation and significantly lower reoperation rates, and should be used when fracture geometry permits (Types 1 and 2). Design: Retrospective review of a consecutive clinical case series. Setting: Level 1 academic trauma service, Public Hospital. PMID:23493665

Bhatia, Deepak N.; Page, Richard S.

2012-01-01

41

New proposed clinico-radiologic and molecular criteria in hypochondroplasia: FGFR 3 gene mutations are not the only cause of hypochondroplasia.  

PubMed

We applied a comprehensive set of clinical and radiological criteria for the diagnosis of hypochondroplasia (HCH) in 160 patients with short stature 58 of whom were diagnosed to have HCH. Taking into account the genotypic and phenotypic variations in HCH, we conducted a study with these 58 patients and tested them for mutations in the fibroblast growth factor receptor 3 (FGFR3) and the short stature homeobox (SHOX) gene. We characterized the phenotypes by clinical and radiologic findings. In the patients with HCH, 19 were included in Group I (FGFR3 mutations-mutations of definite significance), and 39 were in Group II (6 SHOX mutations and 33 negative for disease-causing FGFR3 mutations). The clinical findings were similar in two groups regardless of the presence or absence of mutations. More than 95% of the patients had mesomelic proportions. In Group I, the radiological findings of mesomelia of upper and lower limbs and, L1/L4 ratio in anterior-posterior and lateral view were more typical than in Group II. This study proposes comprehensive clinico-radiological criteria for the diagnosis of HCH, which would help in detecting the true incidence of this underdiagnosed condition. The presence of SHOX mutations suggest genotypic-phenotypic overlap between HCH and Leri-Weill dyschondrosteosis, though further investigation is needed to effectively elucidate the importance of these mutations. Also, the 56.9% of HCH patients with negative mutations for FGFR3 suggests that there are other undiscovered gene mutations associated with this phenotypic entity. PMID:22903874

Song, Sang-Heon; Balce, Gracia Cielo Estrera; Agashe, Mandar Vikas; Lee, Hanna; Hong, Suk-Joo; Park, Young-Eun; Kim, Sang-Gyun; Song, Hae-Ryong

2012-10-01

42

Entrevista con Enrique Buenaventura  

E-print Network

, era muy terrible ya, realmente muy feroz, esta escalada somocista. En tonces, la respuesta también fue tan firme que empezó a desmoralizar a la Guardia. Te contaré un caso. En Masalla, en el mercado, las vendedoras nos contaron cómo se había... refugiado allí la Guardia, muy bien armada, con mucho parque y resultaba muy difícil sacarla de allí. Entonces las mismas mujeres del mercado, que había sido anteriormente bombardeado, salieron en grupo y fueron a tocar a la puerta donde estaba metida la...

Dí ez, Luys A.

1981-04-01

43

Entrevista con José Triana  

E-print Network

cenagoso. ¿Tú has visto a esos equilibristas que atraviesan de un lado a otro en un circo, en una cuerda floja? Y tú los ves que van pasando. . . . Pues eso yo creo que es una de las definiciones que podría plantearme o replantearme con la escritura... es su teoría del distanciamiento . . . Eso me interesa mucho, y sobre todo distanciamiento en el sentido de la representación. La obra de Ramón del Valle-lnclán es totalmente distinta de la obra de Bertolt Brecht, y sin embargo tienen un punto...

Vasserot, Christilla

1995-10-01

44

Evaluation of Serum Levels of HER2, MMP-9, Nitric Oxide, and Total Antioxidant Capacity in Egyptian Breast Cancer Patients: Correlation with Clinico-Pathological Parameters  

PubMed Central

Breast cancer is by far the most common cancer in women worldwide and the main cause of cancer-related mortality. Breast cancer accounts for 38% of all malignancies among Egyptian women. The aim of our study was to evaluate the serum levels of human epidermal growth factor receptor-2 (HER2), matrix metalloproteinase-9 (MMP-9), nitric oxide (NO), and total antioxidant capacity (TAC) in breast cancer patients and to correlate these markers with clinico-pathological parameters. Serum HER2, MMP-9, and carcinoma antigen 15-3 (CA 15-3) were assessed in 80 breast cancer patients and ten healthy subjects as a control group by the enzyme-linked immunosorbent assay (ELISA) technique while NO and TAC were assessed by a colorimetric method. Serum HER2 was ?15 ng/mL in nine patients (11.3%). High HER2 ECD levels were significantly associated with tissue HER2 (P<0.0001), metastasis (P= 0.0024), and negativity of both estrogen (P=0.0075) and progesterone (P=0.0239) receptors. Serum MMP-9 (P=0.0013), NO (P<0.0001), and CA 15-3 (P<0.0001) were significantly increased while serum TAC was significantly (P=0.01) decreased in breast cancer patients as compared to the control group. Serum MMP-9 was increased significantly (P=0.028) in metastatic patients as compared to non-metastatic patients. We found a positive correlation between serum HER2 and CA 15-3 (r=36, p=0.005). In conclusion, serum HER2 reflects the tissue HER2 status of breast cancer, so the determination of serum HER2 is helpful in assessing HER2 status, but in addition, a high level may reflect metastatic disease. Also, serum MMP-9 can be useful for denoting the development of metastasis in breast cancer patients. Follow-up is needed to evaluate the value of serum HER2 and MMP-9 as prognostic markers. PMID:24634847

Rashad, Yara A.; Elkhodary, Tawfik R.; El-Gayar, Amal M.; Eissa, Laila A.

2014-01-01

45

Planificación Neuroquirúrgica con Software Osirix  

PubMed Central

Introducción: La individualidad anatómica es clave para reducir el trauma quirúrgico y obtener un mejor resultado. Actualmente, el avance en las neuroimágenes ha permitido objetivar esa individualidad anatómica, permitiendo planificar la intervención quirúrgica. Con este objetivo, presentamos nuestra experiencia con el software Osirix. Descripción de la técnica: Se presentan 3 casos ejemplificadores de 40 realizados. Caso 1: Paciente con meningioma de la convexidad parasagital izquierda en área premotora; Caso 2: Paciente con macroadenoma hipofisario, operada previamente por vía transeptoesfenoidal en otra institución con una resección parcial; Caso 3: Paciente con lesiones en pedúnculo cerebeloso medio bilateral. Se realizó la planificación prequirúrgica con el software OsiriX, fusionando y reconstruyendo en 3D las imágenes de TC e IRM, para analizar relaciones anatómicas, medir distancias, coordenadas y trayectorias, entre otras funciones. Discusión: El software OsiriX de acceso libre y gratuito permite al cirujano, mediante la fusión y reconstrucción en 3D de imágenes, analizar la anatomía individual del paciente y planificar de forma rápida, simple, segura y económica cirugías de alta complejidad. En el Caso 1 se pudo analizar las relaciones del tumor con las estructuras adyacentes para minimizar el abordaje. En el Caso 2 permitió comprender la anatomía post-operatoria previa del paciente, para determinar la trayectoria del abordaje transnasal endoscópico y la necesidad de ampliar su exposición, logrando la resección tumoral completa. En el Caso 3 permitió obtener las coordenadas estereotáxicas y trayectoria de una lesión sin representación tomográfica. Conclusión: En casos de no contar con costosos sistemas de neuronavegación o estereotáxia el software OsiriX es una alternativa a la hora de planificar la cirugía, con el objetivo de disminuir el trauma y la morbilidad operatoria. PMID:25165617

Jaimovich, Sebastián Gastón; Guevara, Martin; Pampin, Sergio; Jaimovich, Roberto; Gardella, Javier Luis

2014-01-01

46

Pancytopenia: A Clinico Hematological Study  

PubMed Central

Background: Pancytopenia is a relatively common hematological entity. It is a striking feature of many serious and life-threatening illnesses, ranging from simple drug-induced bone marrow hypoplasia, megaloblastic anemia to fatal bone marrow aplasias and leukemias. The severity of pancytopenia and the underlying pathology determine the management and prognosis. Thus, identification of the correct cause will help in implementing appropriate therapy. Objectives: To study the clinical presentations in pancytopenia due to various causes; and to evaluate hematological parameters, including bone marrow aspiration. Materials and Methods: It was a prospective study, and 104 pancytopenic patients were evaluated clinically, along with hematological parameters and bone marrow aspiration in Hematology Unit, Department of Pathology, JJMMC, Davanagere, during the period of September 2005 to September 2007. Results: Among 104 cases studied, age of patients ranged from 2 to 80 years with a mean age of 41 years, and male predominance. Most of the patients presented with generalized weakness and fever. The commonest physical finding was pallor, followed by splenomegaly and hepatomegaly. Dimorphic anemia was the predominant blood picture. Bone marrow aspiration was conclusive in all cases. The commonest marrow finding was hypercellularity with megaloblastic erythropoiesis. The commonest cause for pancytopenia was megaloblastic anemia (74.04%), followed by aplastic anemia (18.26%). Conclusion: Thepresent study concludes that detailed primary hematological investigations along with bone marrow aspiration in cytopenic patients are helpful for understanding disease process and to diagnose or to rule out the causes of cytopenia. These are also helpful in planning further investigations and management. PMID:21701657

Gayathri, B N; Rao, Kadam Satyanarayan

2011-01-01

47

Quick Chili Con Carne Ingredients  

E-print Network

Quick Chili Con Carne Ingredients: 16 ounces kidney beans, canned 1 pound ground turkey 1/2 onion 1 is cooking, cut the ends off of the onion, and peel off the brown layers. Cut onion in half and place flat side down. Slice into thin strips keeping onion together. Turn and slice again to dice. 4. Slice green

Liskiewicz, Maciej

48

A clinical study of cysts of the maxillofacial region; and an assessment of clinico-radiologico-pathological variables affecting the formulation of a comprehensive patient need based treatment plan  

PubMed Central

Objectives: Evaluation of clinical presentation of cystic lesions of the maxillofacial region, their relation to radiological picture, and treatment planning so as to plan and execute a patient need based treatment modality after co-relating it to the eventual histopathological diagnosis. Methods: 25 cases with clinico-radiological diagnosis of a cyst were selected and treated, and the diagnosis was co-related to the eventual histopathological diagnosis. The patients were followed up for at least 3 months (3-12 months). An attempt was made to underline patient and lesion related variables having a bearing on the choice of treatment modality in each case. Results: Out of 25 patients, 28% were females and 72% males. Commonly affected age groups were 11-20 (40%) and 31-40 years (24%). 76% of 25 patients complained of swelling on the first visit. 96% lesions were related to jaws, of which 15 were in the mandible and 9 were in the maxilla. 58.33% bone lesions had cortical expansion. 92% lesions were confirmed to be cysts histopathologically. Two were ameloblastomas. 80% patients underwent enucleation with various adjunctive procedures. 32% patients faced temporary post operative complications. No recurrences were observed. Radiological presentation of lesions and patient's age were found to be the two most important radiological and clinical variables affecting treatment planning. Conclusions: A comprehensive patient need based treatment plan can be reached only after taking various patient and lesion related variables (which may manifest as clinical, radiological or histological parameters) into consideration. PMID:25565728

Paul, Samrity; Kapoor, Vinod; Kumar, Munish; Narula, Ravi; Kapoor, Varun; Kapoor, Upasna

2014-01-01

49

[CONs].  

PubMed

In 2012, USA Preventive Services Task Force revised the guidelines for prostate cancer screening and recommended against prostate specific antigen(PSA)-based screening for prostate cancer for all age groups. This revision had a great impact worldwide. Immediately after the announcement, many expert societies expressed disagreement with this revision, but some of these have gradually come to accept it. When multiple organizations develop guidelines for a particular topic, the recommendations may differ. In this regard, the "standards for developing trustworthy clinical practice guidelines" presented in the report by the Institute of Medicine, will be helpful. The number of cases and the incidence rates of prostate cancer have been rapidly increasing in Japan, especially in the elderly population. Accordingly, sufficient information needs to be provided for appropriate decision-making, considering the balance between the risks and benefits, if cancer screening in the elderly population is to be implemented. PMID:24917002

Sobue, Tomotaka

2014-05-01

50

Computacion inteligente con organismos vivos  

E-print Network

resoluci´on. 2 / 37 #12;Computaci´on y M´aquinas ... VIVAS e INTELIGENTES 3 / 37 #12;Modelo de computaci tediosas... ... y otras tareas inteligentes. 7 / 37 #12;M´aquinas de prop´osito espec´ifico Desde el ´abacoComputaci´on inteligente con organismos vivos Mario de Jes´us P´erez Jim´enez Grupo de Investigaci

Jiménez, Mario de J. Pérez

51

todasuvida: Las personas con diabetes son ms  

E-print Network

diabetes Controlesu todasuvida: Las personas con diabetes son más propensas a padecer de enfermedades del corazón que quienes no tienen diabetes. Boletín 631 D Las personas con diabetes tienen mayor- res relacionados con la diabetes, como derrame cerebral, mala circulación en las piernas y pies e

52

Una tarde con Héctor Mendoza  

E-print Network

hay más. Mira, realmente, les voy a contar. Lo que me sucede ahora es que me he preocupado terriblemente por la teoría de la actuación, y lo que estoy haciendo son textos teóricos sobre la actuación. Ahora lo que hago es una obra mezclada con la... teoría de la actuación. Siento que tomar un texto de los Siglos de Oro, que son textos que ya me son muy familiares, entonces, se me facilita muchísimo más para su manejo; en este sentido, ¿no? Ahora, yo siento que se me facilita también tomar un texto...

Padró n-Leó n, Bá rbara A.; Peale, C. George

1999-10-01

53

¡Truco Con Agua!  

NSDL National Science Digital Library

En esta actividad los aprendices aprenderán un truco de magia donde la magia es la presión del aire. Los participantes tomarán un vaso de agua medio lleno y lo taparán con un pedazo de plástico o cartón. Sosteniendo la tarjeta contra el vaso, lo voltearán boca abajo y cuando quiten la mano debajo del vaso, ¡abracadabra! no se caerá el agua. En la tira cómica, Mateo explica a los aprendices que la presión que hace el aire en todas las direcciones es la que sostiene la tarjeta.

Science, Lawrence H.

2009-01-01

54

Opciones de cirugía para mujeres con CDIS o con cáncer de seno  

Cancer.gov

Contiene información sobre los tipos de cirugía de seno, como la operación para conservar el seno y la mastectomía, y ayuda a las mujeres diagnosticadas con CDIS o con cáncer de seno a decidir cuál cirugía es la más conveniente para ellas.

55

Aggressive periodontitis: A clinico-hematological appraisal  

PubMed Central

Background: Human leukocyte antigens (HLA) have been considered a candidate of genetic risk markers for aggressive periodontitis (AP). AP has also been associated with polymorphonuclear leukocyte (PMN) dysfunction. The role of monocyte subsets in AP has also not been completely explored. Therefore, the present study was undertaken to assess in, AP subjects, the possible association between defective PMN adhesion and ?2-integrin expression; defective neutrophil migration and actin polymerization level; the expression of ABO blood group and HLA antigen; and the percentage of CD14+ CD16+ monocytes and CD45RA monocytes. All these parameters have been compared with the subjects of chronic periodontitis (CP) and healthy controls. Materials and Methods: A total of 45 subjects of the age group 20-50 years, free from any known systemic disease, were divided into three groups – Group I - periodontally healthy control (n = 15), Group II - CP (n = 15) and Group III - AP (n = 15). Peripheral blood samples were collected. ABO grouping and HLA typing were performed. ?2-integrin expression, actin polymerization level and percentage of CD14+ CD16+ monocytes and CD45RA monocytes were estimated by fluorescence-activated cell sorter analysis. Results: Most of the subjects of AP belonged to the blood group AB, and an increased frequency of HLA-A30, CW1 and DR1 (P < 0.1) and B44 and DQ2 (P < 0.05) were also observed in this group. In the AP group, both average values (?2-integrin and actin level) were significantly less than those of normal subjects (P < 0.001). The mean percentage of CD14+ CD16+ monocytes was found to be maximum in CP, followed by AP, and then in healthy subjects, while the mean percentage of CD45RA was maximum in AP, followed by CP, and then in healthy subjects. Conclusions: With the present state of knowledge from this study, a definite association of ABO blood groups and HLA phenotypes with periodontal diseases is yet to be established. Leukocytic functional defects were found in AP subjects. A statistically significant percentage of CD14+ CD16+ and CD45RA monocytes were found in AP subjects as compared with the normal control and CP groups. PMID:24872623

Kundu, Debabrata; Bandyopadhyay, Prasanta; Nair, Vineet; Chowdhury, Mona; Mukherjee, Saswati; Nayek, Moumita

2014-01-01

56

INFECCION POR CITOMEGALOVIRUS CON COMPROMISO HEPATICO EN ADULTOS INMUNOCOMPETENTES  

Microsoft Academic Search

Resumen Evaluamos retrospectivamente a 73 adultos inmunocompetentes que consultaron entre marzo de 1999 y marzo de 2004 a un centro infectológico ambulatorio por fiebre y astenia, con elevación discreta de las transaminasas y serología compatible con infección reciente por citomegalovirus (CMV). Excluimos a pacientes con antecedentes de transfusiones, adicciones e inmunodeficiencias, así como aquellos con altera- ciones hepáticas preexistentes o

CLAUDIA VUJACICH; GABRIELA VIDIELLA; LAURA BARCELONA; EDGARDO STURBA; DANIEL STAMBOULIAN

57

iCons, 2011 Cholera in Haiti  

E-print Network

© iCons, 2011 Cholera in Haiti Handouts: 1. 1-page explainer of cholera outbreak in Haiti Assignments Part 1: Developing an Explainer 1. In-class written assignment of societal challenge with cholera in Haiti 2. In-class written assignment of scientific investigation relating to cholera 3. Take

Auerbach, Scott M.

58

InterCon Travel Health: Case B  

ERIC Educational Resources Information Center

InterCon provides services to health insurers of foreign tourists who travel to the United States and Canada. Management wants to implement a new information system that will deal with several operational problems, but it is having difficulty securing the capital resources to fund the system's development. After an initial failure, the chief…

Truman, Gregory E.; Pachamanova, Dessislava A.; Goldstein, Michael A.

2010-01-01

59

CON Advising Academic Year 2013-2014  

E-print Network

' personal, academic, and career goals. This advisor/student partnership requires participationCON Advising Academic Year 2013-2014 Advisors: Rita Tower Kelly Fanning Office: Garrand 403 Garrand students to make decisions about their academic, personal and professional pathways, and to encourage

Carter, John

60

LA MAESTRA EN CIENCIAS (NEUROBIOLOGA), Con el objetivo de formar profesionales con conocimientos slidos de los  

E-print Network

LA MAESTRÍA EN CIENCIAS (NEUROBIOLOGÍA), Con el objetivo de formar profesionales con conocimientos, neurociencias, psicobiología, física, matemáticas, estadística y metodología de la ciencia, a presentar su Nacional de Posgrado de Calidad del Consejo Nacional de Ciencia y Tecnología en categoría: COMPETENTE

Islas, León

61

Insercin y fusin con listas ordenadas: un ejemplo de razonamiento automtico con ACL2  

E-print Network

Inserción y fusión con listas ordenadas: un ejemplo de razonamiento automático con ACL2 F. Palomo formales, razonamiento automático, len- guaje de programación aplicativo, ACL2, NQTHM Resumen En este artículo presentamos un ejercicio de formalización y demostración automática en ACL2, un sistema de

Alonso, José A.

62

Watch Globally, Think Locally CON-CAN Movie Festival  

E-print Network

CORTO TOKYO 2010 Watch Globally, Think Locally 12 18 12 19 12 20 70 CON-CAN Movie Festival CON-CAN Movie Festival Presents www.con-can.com #12;90 COMPETITION 1 : Play Expression COMPETITION 2 : Twilight TOKYO 2010 CON-CAN Movie Festival 151-0051 4-14-4 SK 4F Tel: 03-5414-6532 E-mail : cortokyo

Kasahara, Hironori

63

Feature Speci cation and Automatic Con ict Detection  

E-print Network

Feature Speci#12;cation and Automatic Con ict Detection #3; Amy P. Felty y Kedar S. Namjoshi School of automatically detecting feature con icts (\\undesirable inter- actions") at the speci#12;cation stage. Early con ict detection can help prevent costly and time-consuming problem #12;xes during implementa- tion

Felty, Amy

64

The evolution of female mate choice by sexual con ict  

E-print Network

The evolution of female mate choice by sexual con ict Sergey Gavrilets1* , Go« ran Arnqvist2 a quantitative genetic model showing that sexual con£ict over mating indeed results in the joint evolution. Keywords: sexual selection; sexual con£ict; evolution of female mate choice; mathematical models 1

Gavrilets, Sergey

65

Too Many Minas Spoil The Con  

E-print Network

1 12:08 pm February 13th, 2007 vuirneen A semi-private email to Mina de Malfois Is anyone familiar with the writings of mina_de_malfois? I wrote this email to her, based entirely on her Minaverse, between... midnight and two am last night and I just wanted someone to check it before I send it to her. Too Many Minas Spoil The Con Dear Mina, I'm not quite sure how to start this letter. I feel as though I've failed a test of some kind and that if I only...

2007-02-13

66

Enriquecimiento del pienso de dorada con quitina y paredes de levaduras con fines preventivos  

Microsoft Academic Search

Preventive dietary supplements of chitin and yeast wall in gilthead seabream To determine the immunomodulatory effect of the dietary intake of commercial chitin and yeast cell walls in gilthead seabream, Sparus auratus Linnaeus, 1758, specimens were fed diets containing different con- centrations of chitin or yeast cell walls for 1, 2, 4 or 6 weeks. Subsequently, their main humoral (lysozyme

A. Rodríguez; M. A. Esteban; A. Cuesta; J. Ortuño; J. Polaina; J. Meseguer

67

Con ict-free colorings J anos Pach  

E-print Network

Con ict-free colorings J#19;anos Pach G#19;eza T#19;oth Abstract A coloring of the elements of a planar point set P is said to be con ict-free if, for every closed disk D whose intersection with P, and Smorodinsky by showing that any con ict-free coloring of every set of n points in the plane uses at least c

Pach, János

68

Tiene familiares con Alzheimer? La Escuela de Medicina del Recinto de Ciencias Mdicas en colaboracin con la Universidad de Columbia  

E-print Network

¿Tiene familiares con Alzheimer? 25/1/2008 La Escuela de Medicina del Recinto de Ciencias Médicas más con Alzheimer para participar de un estudio genético. La investigación pretende encontrar genes que se encuentren relacionados a la enfermedad de Alzheimer con el propósito de aprender más sobre las

Quirk, Gregory J.

69

October 6, 1997 ITER L-Mode Con nement Database  

E-print Network

October 6, 1997 ITER L-Mode Con nement Database S.M. Kaye and the ITER Con nement Database Working Group Abstract This paper describes the content of an L-mode database that has been compiled with data, and Tore-Supra. The database consists of a total of 2938 entries, 1881 of which are in the L-phase while

70

VENTAJAS DEPORTIVAS ENTIDADES COLABORADORAS CON EL SERVICIO DE DEPORTES  

E-print Network

VENTAJAS DEPORTIVAS ENTIDADES COLABORADORAS CON EL SERVICIO DE DEPORTES WHITE PEPPER Pub DEPORTES #12;Alicante C.F. universitaria que sean titulares de la TIU. Organización conjunta de actividades Universitarios que anualmente convoca el Consejo Superior de Deportes, a aquellos jugadores que cumplan con los

Escolano, Francisco

71

RoboCon: A general purpose telerobotic control center  

SciTech Connect

This report describes human factors issues involved in the design of RoboCon, a multi-purpose control center for use in US Department of Energy remote handling applications. RoboCon is intended to be a flexible, modular control center capable of supporting a wide variety of robotic devices.

Draper, J.V.; Noakes, M.W. [Oak Ridge National Lab., TN (United States). Robotics and Process Systems Div.; Schempf, H. [Carnegie Mellon Univ., Pittsburgh, PA (United States); Blair, L.M. [Human Machine Interfaces, Inc., Knoxville, TN (United States)

1997-02-01

72

Control del dolor: Apoyo para las personas con cáncer  

Cancer.gov

Contiene información sobre las medicinas contra el dolor para pacientes con cáncer, los planes para controlarlo, cómo hablar con su equipo de atención médica sobre el dolor que usted siente y qué hacer para controlar los efectos físicos y emocionales del mismo.

73

-okfl ^ ORNL/CON-172 Linear Harmonic Analysis of Free-  

E-print Network

-okfl ^ ORNL/CON-172 OAK RIDGE NATIONAL LABORATORY Linear Harmonic Analysis of Free- Piston. #12;ORNL/CON-172 Engineering Technology Division* LINEAR HARMONIC ANALYSIS OF FREE-PISTON STIRLING/dynamic problem that is associated with a free-piston Stirling engine (FPSE). The governing equations

Oak Ridge National Laboratory

74

Introduzione alla programmazione client-side (con Javascript)  

E-print Network

1 MODULO 2 PARTE 4 Introduzione alla programmazione client-side (con Javascript) Goy - a.a. 2009/2010 Programmazione Web client side (con Javascript) 1 · Javascript è un linguaggio di scripting, tipicamente Javascript · Come tutti i linguaggi di scripting, è interpretato: il sorgente non deve essere compilato per

Goy, Anna

75

Introduzione alla programmazione client-side (con Javascript)  

E-print Network

1 MODULO 2 PARTE 4 Introduzione alla programmazione client-side (con Javascript) Goy - a.a. 2012/2013 Programmazione Web client side (con Javascript) 1 Il fil rouge del MODULO 2 PARTE 4: Introduzione alla progr. client-side · Javascript · DOM e gestori di eventigli oggetti del DOM... PARTE 5: Programmare sul Web 2

Goy, Anna

76

Introduzione alla programmazione client-side (con Javascript)  

E-print Network

1 MODULO 2 PARTE 4 Introduzione alla programmazione client-side (con Javascript) Goy - a.a. 2011/2012 Programmazione Web client side (con Javascript) 1 Il fil rouge del MODULO 2 PARTE 4: Introduzione alla progr. client-side · Javascript · DOM e gestori di eventigli oggetti del DOM... PARTE 5: Programmare sul Web 2

Goy, Anna

77

Introduzione alla programmazione client-side (con Javascript)  

E-print Network

1 MODULO 2 PARTE 4 Introduzione alla programmazione client-side (con Javascript) Goy - a.a. 2010/2011 Programmazione Web client side (con Javascript) 1 · Javascript è un linguaggio di scripting, tipicamente Javascript · Come tutti i linguaggi di scripting, è interpretato: il sorgente non deve essere compilato per

Goy, Anna

78

Con Edison Commercial and Industrial Energy Efficiency Program  

E-print Network

1 Con Edison Commercial and Industrial Energy Efficiency Program Discussion Overview ? Benefits, Eligibility & Team Members ? Program Components ? Project Incentives & Energy Studies ? Additional Program Attributes, Tools & Resources... ? Process Overview ? FAQ ? Q&A 2 Benefits For the Con Edison Customer ? Reduced Replacement Costs ? Identify EE Opportunities ? Reduced Operating Costs ? Infrastructure/Value Enhancements ? Carbon Footprint Reduction ? Codes/LEED/Energy Star...

Pospisil, D.

2011-01-01

79

Breath Analysis Science at PittCon 2012, Orlando, Florida  

EPA Science Inventory

Breath analysis science was featured in three organized sessions at this year?s Pittsburgh Conference and Exposition, or ?PittCon 2012? (http://www.pittcon.org/). As described in previous meeting reports, PittCon is one of the largest international conferences for analytical chem...

80

Cálculos ab initio con correlación electrónica  

NASA Astrophysics Data System (ADS)

Estamos entrando en una era donde la ortogonalidad entre las investigaciones de carácter experimental y de naturaleza teórica se irá difuminando progresivamente y la problemática a resolver quedará en escena como el único actor principal de la obra. Como premisa para una cooperación teórico-experimental de igual a igual, la metodología químico-cuántica utilizada debe ser capaz de ofrecer resultados de carácter predictivo. Sin duda, esta madurez en la metodología químico-cuántica ya la hemos alcanzado hace algunos años, tal y como muestra entre otras muchas, la labor que nuestro grupo ha realizado en el transcurso de la última década, dentro del campo de la Espectroscopía Teórica. Los estudios realizados comprenden una amplia gama de sistemas, variando tanto en tamaño como en complejidad, abordando problemáticas espectroscópicas consideradas tradicionalmente como especialmente controvertidas. Nuestra contribución científica más relevante reside en el carácter cuantitativo de las asignaciones espectroscópicas que hemos propuesto en base a resultados ab initio. Recordemos que en los años noventa los resultados ab initio solían presentar para las energías de excitación de sistemas de tamaño molecular moderado, como el benceno, errores de más de 1 eV. En comparación con el éxito relativo de los métodos semiempíricos, la frustración de la metodología ab initio quedaba todavía más patente. Los estudios que hemos presentado representan una comprensión profunda de los espectros electrónicos en sistemas orgánicos claves, mostrando el camino a seguir para obtener asignaciones espectroscópicas precisas (entre 0.1-0.2 eV). La naturaleza del método CASPT2 junto al diseño de estrategias computacionales nos ha permitido alcanzar el carácter cuantitativo con el que se caracterizan nuestras contribuciones[1,2]. Por todo ello, algunos de los trabajos publicados se consideran clásicos dentro del campo, pues en cierto modo definen el campo, y se reflejan en libros publicados recientemente. En la conferencia se analizarán ciertos pormenores de las investigaciones realizadas. El tipo de aplicaciones llevadas a cabo hasta la fecha se ilustrará mediante el estudio teórico del espectro electrónico de ciclooctatetraeno. Dando un paso más en la evolución de nuestra investigación, pretendemos en la actualidad describir, desde un formalismo teórico y al mismo nivel de exigencia, los mecanismos subyacentes que tienen lugar en las reacciones biológicas fototoinducidas, es decir, reacciones que se inician mediante la absorción de luz[3]. Como muestra de la caracterización de los procesos fotofísicos y fotoquímicos en fotobiología teórica, hemos elegido la descripción de la conversión interna ultrarrápida que tiene lugar en los cromóforos del ADN. Los estados excitados de las moléculas de los ácidos nucleicos presentan tiempos de vida media que se encuentran en el rango de sub-picosegundos, sugiriendo la presencia de un canal ultrarrápido de conversión interna, lo que normalmente se asocia en la fotoquímica contemporánea a una intersección cónica entre el estado excitado y el fundamental[4]. De esta forma nuestro ADN previene de forma eficaz posibles reacciones en el estado excitado y se revela como un excelente protector solar.

Merchán Bonete, M.

81

Manejo anestésico en la corrección toracoscópica de atresia de esófago tipo I con ventilación unipulmonar con modalidad de flujo continuo  

Microsoft Academic Search

Resumen Describimos el modo de ventilación con flujo conti- nuo para la reparación de un caso de atresia de esófa- go tipo I en un lactante. Este tipo de atresia se carac- teriza por estenosis esofágica distal, con bolsón proximal sin fístula en el árbol bronquial. Las técni- cas clásicas quirúrgicas realizan la reparación por toracotomía, pero la nueva introducción

F. García-Montoto; F. Martínez; N. Falcone; I. Cano; P. Rubio

82

DESAFÍOS ÉTICOS DE LA INVESTIGACIÓN CON ANIMALES, MANIPULACIÓN GENÉTICA  

PubMed Central

En la investigación con animales existen cuestionamientos éticos tanto en el uso como modelos de enfermedades humanas y requisito previo para ensayos en humanos como en la introducción de modificaciones genéticas. Algunos de estos cuestionamientos son: no representar exactamente la condición humana como modelos, realizar pruebas de toxicidad con grave daño para los animales, alterar su naturaleza mediante modificaciones genéticas, riesgos de la introducción de organismos genéticamente modificados. El uso de animales en investigación para beneficio humano, impone al ser humano la responsabilidad moral de respetarlo, no haciéndoles sufrir innecesariamente, al estar trabajando con seres vivientes y sentientes. PMID:23338641

Yunta, Eduardo Rodríguez

2012-01-01

83

9 CFR 319.301 - Chili con carne with beans.  

Code of Federal Regulations, 2011 CFR

...301 Section 319.301 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE...OR COMPOSITION Canned, Frozen, or Dehydrated Meat Food Products § 319.301 Chili con carne with...

2011-01-01

84

Control del dolor: Apoyo para las personas con cáncer  

Cancer.gov

Libro sobre el control del dolor en pacientes con cáncer. Cubre los métodos y medicinas, así como los efectos físicos y emocionales del dolor. Es una adaptación cultural para el público de habla hispana del libro en inglés Pain Control.

85

iCons, 2011 Alzheimers and Aluminum: Lesson Plan  

E-print Network

© iCons, 2011 Alzheimers and Aluminum: Lesson Plan Handouts to explore mechanistic link between Alzheimer's and aluminum 5. Brief proposal expanding Points to Aluminum's Link With Alzheimer's Disease" from 1989. Provide handout

Auerbach, Scott M.

86

Multilevel Annotation in SpeeCon Polish Speech Database  

Microsoft Academic Search

\\u000a SpeeCon Polish Speech Database was collected within the framework of the SpeeCon project partially sponsored by the EC (IST-1999-10003).\\u000a The database contains two sets of data, which comprise 550 adults’ recording sessions and 50 sessions from children, respectively.\\u000a The adult speakers were recorded in various environments: offices, living rooms, cars and public places. Recordings contain\\u000a free spontaneous speech passages, elicited

Krzysztof Marasek; Ryszard Gubrynowicz

2004-01-01

87

El teatro como reflexión colectiva: Conversación con Sergio Corrieri  

E-print Network

SPRING 1983 51 El teatro como reflexión colectiva: Conversación con Sergio Corrieri Gerardo Luzuriaga Sergio Corrieri es el director del renombrado Teatro Escambray, fundado por él y otros teatristas de La Habana en 1968 en la región del... propios del subdesarrollo. La superstición, por ejemplo, muy extendida en nuestras zonas rurales; el reparo del campesino, sus dudas ante la colectivización del trabajo agrícola, ante el hecho de unir sus esfuerzos con los de otros campesinos, y en...

Luzuriaga, Gerardo

1983-04-01

88

Teaching after Retirement: The Pros and the Cons  

ERIC Educational Resources Information Center

Having enjoyed teaching during my active career, I continued to teach summer school following retirement. Self-observed sensory and cognitive impairments, although not mentioned by students in their evaluations, induced me to consider the pros and cons of continuing to teach. My hope is that this list of benefits and problems will be of assistance…

Sommer, Robert

2014-01-01

89

Redes Reconfigurables Controladas por Marcado: Redes de Petri con Cambios  

E-print Network

Redes Reconfigurables Controladas por Marcado: Redes de Petri con Cambios Din´amicos Estructurales a cambios din´amicos utilizando exten- siones de redes de Petri. En estudios previos, hemos introducido los siste- mas de reescritura de redes y una subclase de los mismos llamada redes reconfigurables. En un

Alpuente, María

90

con Diabetes Su diabetes s se puede controlar!  

E-print Network

Do Well, Be Well con Diabetes ¡Su diabetes sí se puede controlar! Educational programs of the Texas, and the County Commissioners Courts of Texas Cooperating. to develop diabetes self-care skills, to improve eating habits and maintain good nutrition, to increase physical activity, to prevent diabetes complications

91

Providers debate pros and cons of pneumonia vaccination at discharge.  

PubMed

When to vaccinate against pneumonia? Does it makes sense when patients are in the hospital? Or should patients wait for the first post-op visit with the PCP? Office-based and hospital-based physicians weigh the pros and cons of each. PMID:11246808

2001-02-01

92

Problemas resueltos de variable compleja con elementos de teoria  

E-print Network

Problemas resueltos de variable compleja con elementos de teor´ia Ignacio Monterde, Vicente Montesinos. #12;´Indice general Introducci´on V 1. Teor´ia elemental 1 1.1. Elementos de teor´ia . . . . . . . . 55 1.2.8. Integraci´on compleja . . . . . . . . . . . . . . . . . . . 57 2. La teor´ia de las

Montesinos Santalucía, Vicente

93

Detail of conning tower atop the submarine. Note the wire ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Detail of conning tower atop the submarine. Note the wire rope wrapped around the base of the tower, which may have been used in an attempt to pull the submarine offshore. - Sub Marine Explorer, Located along the beach of Isla San Telmo, Pearl Islands, Isla San Telmo, Former Panama Canal Zone, CZ

94

ConNexus to awarenex: extending awareness to mobile users  

Microsoft Academic Search

We explored the use of awareness information to facilitate communication by developing a series of prototypes. The ConNexus prototype integrates awareness information, instant messaging, and other communication channels in an interface that runs on a desktop computer. The Awarenex prototype extends that functionality to wireless handheld devices, such as a Palm. A speech interface also enables callers to make use

John C. Tang; Nicole Yankelovich; James Begole; Max Van Kleek; Francis C. Li; Janak R. Bhalodia

2001-01-01

95

Un estudio eto-espacial con variables ambientales  

Microsoft Academic Search

La dinámica eto-espacial, en función de la variable ambiental, es un estudio desde el Enfoque paradigmático de la Psicología Ambiental. Se ha desarrollado en el foso de papiones sagrados (hamadryas) y anubis del Zoológico de Barcelona. Se han estudiado las posibles influencias del medio ambiente con respecto a la conducta, tanto en el contexto espacial como social. Se han utilizado

Josep Maria Amenós i Vidal; Joan Josep Tharrats i Pascual

1984-01-01

96

Peces asociados con la deriva de macroalgas en Aysén, Chile  

Microsoft Academic Search

Resumen.- La obtención de restos de macroalgas flotando a la deriva en aguas frente al sur de Chile permite, por primera vez, explorar la presencia de peces nadando junto con ellas. Se registra la presencia del pez aguja Leptonotus blainvilleanus (familia Syngnathidae); la cojinova Seriolella porosa (familia Centrolophidae); el pampanito, Stromateus stellatus (familia Stromateidae) y el torito Bovichtus sp. (familia

Germán Pequeño; Daniela Farías; Martín Thiel; Iván Hinojosa

2004-01-01

97

ortl ORNL/CON-309 AN ASSESSMENT OF  

E-print Network

Meckler Associates, P.C. July 1992 Prepared by the OAK RIDGE NATIONAL LABORATORY Oak Ridge, Tennessee RIDGE NATIONAL LABORATORY Oak Ridge, Tennessee 37831-6285 managed by MARTIN MARIETTA ENERGY SYSTEMS, INCortl ORNL/CON-309 AN ASSESSMENT OF DESICCANT COOLING OAK RIDGE AND NATIONAL DEHUMIDIFICATION

Oak Ridge National Laboratory

98

Cómo hacer las gestiones con su plan de salud  

Cancer.gov

Hay formas de saber si su plan de salud cubre los costos de atención médica de rutina durante un estudio clínico. Esta información puede servirle para saber con quién comunicarse para solicitar ayuda, preguntas que puede hacer y la información que debe recoger y guardar si decide participar en un estudio clínico.

99

Clinico-pathological aspects of the neurosyphilitic psychoses  

PubMed Central

(1) The immediate causes of death of eighteen patients with neurosyphilitic psychosis are analysed. There were five females and thirteen males. Their average age was 56 years, and the mean length of stay in a mental hospital was approximately 2½ years. (2) Of the original ninety-one patients, twenty-eight had malaria therapy. There was one death due to malaria therapy, giving a mortality rate of 3·6%. It is concluded that the risk associated with malaria is too great and fever induced by bacterial pyrogens is safer and just as effective. (3) The duration of mental symptoms before treatment was started is analysed. In one group there was a delay of between 1 and 4 years before treatment was given. In six patients the disease ran a rapidly fatal course in spite of adequate antibiotics. Combined treatment may be beneficial in such cases as fever facilitates the penetration of penicillin into the cerebrospinal fluid. (4) Of the four cases that came to necropsy, only one had a full pathological and histological examination of the brain and meninges. Although these four patients had profound dementia and considerable deterioration of the personality only minimal neuropathological and histological changes were found. It would seem that the widespread use of antibiotics has modified the pathological and histological picture in neurosyphilis, corresponding to alterations recently reported in the clinical features of the disease. (5) Such adverse presenting symptoms as epilepsy, and profound dementia associated with pupillary and reflex abnormalities, are discussed. PMID:5738047

Dewhurst, Kenneth

1968-01-01

100

Clinico-Immunological Heterogeneity in Comèl-Netherton Syndrome  

Microsoft Academic Search

Background: Comèl-Netherton syndrome (CN) is characterized by atopic-eczema-like skin abnormalities combined with linear ichthyotic lesions, hair shaft abnormalities and atopy with high IgE levels. Objective: Five children with CN are described. In 2 of the 3 CN patients still alive, analysis of cytokines regulating IgE synthesis was performed. Methods: In peripheral blood mononuclear cells and cultures of purified T cells,

D. Van Gysel; H. Koning; M. R. M. Baert; H. F. J. Savelkoul; H. J. Neijens; A. P. Oranje

2001-01-01

101

[The interstitial organ in weightlessness: a clinico-physiologic model].  

PubMed

We performed an experiment within the 1991 Austromir mission, 3 months preflight, on the 6th inflight and 4th postflight days, respectively. Primary goal was to measure changes in venous blood and plasma sound velocity (BSV, PSV) with lower body suction (LBNP). Contrasting earth-based findings, there was no increase in BSV nor PSV with LBNP inflight. Postflight, the elevation in both values was greater than expected. Taken together with LBNP data from the German 1992 Mir cosmonaut, we propose the hypothesis that the dynamics of tissue fluid exchange is profoundly influenced by m-g adaptation. A further goal of the experiment was to determine volume- and stress-sensitive hormones. The results need validation by additional flight data and might be considered as an important contribution to our understanding of the normal functioning and pathophysiology of the interstitial organ. PMID:8178523

Hinghofer-Szalkay, H; Noskov, V B

1993-01-01

102

[Chronic encephalitis with mesencephalic predominance. A clinico-pathologic case].  

PubMed

A 70 year-old woman presented with a progressive supranuclear ophthalmoplegia, with "apraxia" of eyelid opening, axial akinesia and dementia. CT scan showed a mild cortico-subcortical atrophy and there was a high level of immunoglobulins, with an oligoclonal pattern, without cell reaction in the CSF. The patient died two years after the onset. Post-mortem examination, limited to CNS, showed subacute encephalitis confined to the tectal, pretectal, subthalamic areas and to Ammon's horns. These changes and their location were strongly suggestive of polioencephalomyelitis with or without cancer, in which such a prevalent midbrain involvement has been exceptionally described. PMID:2399410

Dubas, F; Pénisson-Besnier, I; Pouplard-Barthelaix, A; Emile, J

1990-01-01

103

[Fecal incontinence and rectal prolapse. Clinico-functional assessment].  

PubMed

Rectal Prolapse is a rare and distressing condition, with a multifactorial etiopathogenesis. Often, this pathology is associated with fecal incontinence. The recommended approach to the patient with rectal prolapse and fecal incontinence is to repair the prolapse first, then deal particularly with fecal incontinence at a second operation. A retrospective, clinical and manometric study has varying degrees of fecal incontinence. Clinically five of their operation, and a further three patients improved, in two patients the degree of fecal incontinence remained invariable. One patient was worsened after surgery. Manometrically resting and pressure (RAP) was significantly higher in continent patients than in voluntary contraction pressure (MVCP) (p < 0.05) in preoperative testing. Postoperatively, there was a significant increase in the resting anal pressure as well as in maximum voluntary contraction pressure. Patients who remained incontinent had a significantly lower RAP and MVCP than patients who improved our regained continence. In conclusion this study shows an alteration of internal and external sphincteric function in patients with rectal prolapse. The surgical treatment of this disease improves sphincteric function. Incontinent patients with RAP < 10 mmHg and MCVP < 20 mmHg, probably they would be better treated simultaneously either for rectal prolapsus and incontinence. In this kind of patients the perianal proctectomy with total sphincteroplasty could be the elective treatment. PMID:8587707

Santini, L; Pezzullo, L; Caracò, C; Candela, G; Esposito, B

1995-09-01

104

A clinico-pathological study of vulval dermatoses.  

PubMed Central

A long-term review of 108 women suffering from various forms of vulval dermatosis is described and a detailed analysis of those with chronic hypertrophic vulvitis, lichen sclerosus et atrophicus, and neurodermatitis is made. One case of neurodermatitis and two cases of lichen sclerosus progressed to carcinoma but no case of chronic hypertrophic vulvitis became malignant. It is possible that vulval dermatoses occur more commonly in the nulliparous than in the parous women and there is a slight preponderance of women who are blood group A. It is suggested that the term "leukoplakia" should be abandoned and that vulval lesions should be described in precise and meaningful histological terms. Images PMID:1150891

Leighton, P C; Langley, F A

1975-01-01

105

Clinico-radiologic Findings in Group II Caudal Regression Syndrome  

PubMed Central

Caudal regression syndrome (CRS) is a rare congenital abnormality in which a segment of the lumbo-sacral spine and spinal cord fails to develop. The severity of the morphologic derangement inversely correlates with residual spinal cord function. We present a case report of a 10-year-old girl with Group 2 CRS, to emphasize clinical and radiologic findings in this rare abnormality. PMID:24083063

Sharma, Pankaj; Kumar, Sheo; Jaiswal, Awdesh

2013-01-01

106

Rosai-Dorfman disease: A rare clinico-pathological presentation.  

PubMed

Rosai-Dorfman disease (RDD) is also known as Sinus Histiocytosis with Massive Lymphadenopathy (SHML). It is a rare, benign, self-limiting disease of phagocytic histiocytes affecting a young age group presenting with massive painless cervical lymphadenopathy. RDD has nodal and also extra-nodal involvement with episodes of exacerbation and remissions, whose aetiology remains poorly elucidated. It is highly variable in its clinical presentation and response to treatment. Its treatment is poorly defined but the prognosis is usually favourable. Here we are reporting a rare, unusual clinical presentation of cervical lymphadenopathy and nasal mass diagnosed as RDD with cyto-histopathological correlation. Only a few such cases have been reported in the literature. We also emphasise that clinicians and pathologists should always be aware of RDD in making a differential diagnosis of cervical lymphadenopathy. PMID:24611075

Warpe, Bhushan M; More, Shraddha V

2014-01-01

107

Pointwise convergence rate for nonlinear con servation laws  

E-print Network

convergence rate in this case is upper bounded by ku ffl (\\Delta; t) \\Gamma u(\\Delta; t)k L 1 Ÿ const.ffl: (6Pointwise convergence rate for nonlinear con­ servation laws Eitan Tadmor and Tao Tang Abstract. We finitely many shocks. It is well­known that u ffl (\\Delta; t) converges strongly in L 1 to u(\\Delta; t

Tang, Tao

108

Neogene sequence stratigraphy, Nam Con Son Basin, offshore Vietnam  

Microsoft Academic Search

An integrated well log, biostratigraphic, and seismic stratigraphic study of Miocene to Recent deltaic sediments deposited in the Nam Con Son Basin offshore from southern Vietnam shows the influence of eustacy and tectonics on sequence development. Sediments consist of Oligocene non-marine rift-basin fill (Cau Formation), early to middle Miocene tide-dominated delta plain to delta front sediments (TB 1.5 to TB

K. J. McMillen; E. K. Lee; S. S. Hong

1996-01-01

109

TIRO CON ARCO NIVEL II: AVANZADO (3 CONVOCATORIAS) DESCRIPCIN  

E-print Network

las armas de fuego quedó obsoleto y relegado al uso deportivo o de ocio. Como deporte, formó parte de a dianas situadas a 70 metros de distancia. También es deporte paralímpico desde los Juegos Paralímpicos de Tiro con Arco, puede tener un gran interés para la comunidad universitaria: · Porque es un deporte

Escolano, Francisco

110

TIRO CON ARCO NIVEL I: INCICIACIN (2 CONVOCATORIAS) DESCRIPCIN  

E-print Network

aparecer las armas de fuego quedó obsoleto y relegado al uso deportivo o de ocio. Como deporte, formó parte a dianas situadas a 70 metros de distancia. También es deporte paralímpico desde los Juegos Paralímpicos de Tiro con Arco, puede tener un gran interés para la comunidad universitaria: · Porque es un deporte

Escolano, Francisco

111

The Pros and Cons of RFID in Supply Chain Management  

Microsoft Academic Search

This paper presents the pros and cons of using Radio-Frequency IDentification (RFID) in Supply Chain Management (SCM). While RFID has a greater number of benefits than its predecessor, the bar code, it currently comes at a price that many businesses still consider prohibitive. On the one hand, RFID is advantageous because it does not require line-of-sight scanning, it acts to

Katina Michael; Luke Mccathie

2005-01-01

112

Denaturazione termica e meccanica del DNA : teoria a confronto con gli  

E-print Network

Capitolo 3 Denaturazione termica e meccanica del DNA : teoria a confronto con gli esperimenti. DENATURAZIONE TERMICA E MECCANICA DEL DNA : TEORIA A CONFRONTO CON GLI ESPERIMENTI della transizione DNA B-DNA d

Cocco, Simona

113

Métodos con información genética para abordar la complejidad del cáncer de pulmón  

Cancer.gov

Se estima que 220 000 personas recibieron un diagnóstico de alguna forma de cáncer de pulmón en 2010. Es la principal causa de muertes relacionadas con el cáncer, con más de 157 000 muertes previstas en 2010.

114

Recursos relacionados con los exámenes de detección del cáncer de cuello uterino  

Cancer.gov

El NCI tiene información completa y de base científica sobre prevención, exámenes selectivos de detección, diagnóstico, tratamiento, genética y cuidados de apoyo relacionados con el cáncer. Nuestros especialistas en información pueden responder preguntas relacionadas con el cáncer, entre ellas, las que tienen que ver con los exámenes de detección y el tratamiento del cáncer de cuello uterino. Puede comunicarse con nosotros por teléfono, correo electrónico o mensajería instantánea (el chat solo está disponible en inglés).

115

Accesibilidad para personas con debilidad motriz Mac Os X Snow Leopard  

E-print Network

Accesibilidad para personas con debilidad motriz Mac Os X Snow Leopard ASIC ­ 18 de noviembre de 2010 Pág. 1 de 9 GUÍA DE ACCESIBILIDAD PARA PERSONAS CON DEBILIDAD MOTRIZ EN ENTORNO MAC OS X SNOW para personas con debilidad motriz Mac Os X Snow Leopard ASIC ­ 18 de noviembre de 2010 Pág. 2 de 9

Fernández de Córdoba, Pedro

116

Accesibilidad para personas con debilidad auditiva Mac OS X Snow Leopard  

E-print Network

Accesibilidad para personas con debilidad auditiva Mac OS X Snow Leopard ASIC ­ 18 de noviembre de 2010 Pág. 1 de 14 GUÍA DE ACCESIBILIDAD PARA PERSONAS CON DEBILIDAD AUDITIVA EN ENTORNO MAC OS X SNOW LEOPARD MAC OS X Snow Leopard ofrece algunas ayudas para personas sordas o con problemas para escuchar

Fernández de Córdoba, Pedro

117

Las espirales de Fibonacci podran estar relacionadas con la tensin 26/04/2007 Astroseti  

E-print Network

Las espirales de Fibonacci podrían estar relacionadas con la tensión 26/04/2007 Astroseti Las espirales de Fibonacci podrían estar relacionadas con la tensión. La serie de Fibonacci ­ en la cual cada tensión" para crear espirales con la serie de Fibonacci en microestructuras que crecen en laboratorio

Zexian, Cao

118

Sexual con ict and cooperation in butter y reproduction: a comparative study of polyandry  

E-print Network

Sexual con ict and cooperation in butter y reproduction: a comparative study of polyandry hormonesömay each corre- spond to a separate con£ict^cooperation balance between the sexes. Two scenarios. Keywords: nuptial gifts; mating frequency; sexual con£ict; lifetime fecundity 1. INTRODUCTION

Leimar, Olof

119

Modelling Con ict-Resolution Dialogues Fiorella de Rosis, Floriana Grasso, Cristiano Castelfranchi, and Isabella Poggi  

E-print Network

Modelling Con ict-Resolution Dialogues Fiorella de Rosis, Floriana Grasso, Cristiano Castelfranchi play a particu- larly relevant role when agents have to face a con icting situation: impatient, aggressive, polite, persistent, rude: : : people show radically di#11;erent ways of managing con icts

Bari, Università degli Studi di

120

Functional heterogeneity of con ict, error, task-switching, and unexpectedness effects within medial prefrontal cortex  

E-print Network

Functional heterogeneity of con ict, error, task-switching, and unexpectedness effects within Revised 3 August 2010 Accepted 13 August 2010 Available online 20 August 2010 Keywords: ACC Con ict Error cingulate cortex. The proposed theories have included con ict detection, error likelihood prediction

Kastner, Sabine

121

Apoyo a Estudios Geodinamicos con GPS en Guatemala  

NASA Astrophysics Data System (ADS)

El Instituto Geografico Nacional de Guatemala implemento 17 estaciones GNSS en el año 2009, como un proyecto de credito mixto de donacion de equipamiento del Gobierno de Suiza, el cual, este equipamiento de estaciones CORS GNSS es un sistema de recepción y transmisión de datos crudos GPS RInex que utiliza la tecnologia Spider Web de Leica, asi mismo este sistema esta sirviendo para el espablecimiento de un marco geodesico nacional de coordenadas geodesicas oficiales, el cual se calculan u obtienen las velocidades en tiempos temporales programados de las 17 Estaciones CORS. La infraestructura del marco geodesico de Guatemala esta sirviendo de base para las aplicaciones de estudios geodinamicos como el monitoreo de del desplazamiento de las placas tectonicas por medio de un estudio que se inicio en el año de 1999, llamado medicion con GPS el sistema de Fallas de los rios Polochic Motagua de Guatemala, tambien para un estudio que se implemento para deformación de corteza terrestre local en un Volcan Activo de Guatemala llamado Pacaya. Para el estudio de medicion con GPS en el sistema de falla de los Rios del polochic Motagua se implementaron 16 puntos para medir con GPS de dos frecuencias en el año de 1999, el cual, tres puntos son estaciones geodesicas CORS IGS llamados GUAT, ELEN y HUEH, despues en el año de 2003 se hizo otra medicion en un total de 20 puntos, que permitió calcular las velocidades de desplazamieinto de los puntos en mención, usando como referencia el modelo NUVEL 1A de DeMets de la placa de Norteamerica. Este estudio fue en cooperación internacional por la universidad de Nice de Francia y el IGNde Francia. Para el estudio del monitoreo con GPS del volcan activo de Guatemala, se implementaron cuatro puntos al rededor del volcan, el cual, se realizan cuatro mediciones al año, que permiten determinar axialmente la distancias entre los puntos, y rebisar estadisticamente cual es el comportamiento de las distancias en funcion del tiempo, si existen diferencias graduales crecientes o decrecientes, que nos da un indicativo del desplazamiento de la corteza terrestre al rededor del volcan.

Robles, V. R.

2013-05-01

122

Do Well, Be Well with Diabetes 2013 1 Formulario de Registro para Personas con Diabetes Formulario de Registro para Personas con Diabetes 2013  

E-print Network

Do Well, Be Well with Diabetes ­ 2013 1 Formulario de Registro para Personas con Diabetes Formulario de Registro para Personas con Diabetes ­ 2013 Si usted NO TIENE diabetes, por favor NO LLENE este sobre diabetes en el Condado de _______________. D. El código postal en mi casa es __ __ __ __ __. E

123

Do Well, Be Well with Diabetes 2013 1 Formulario de Conclusin para Personas con Diabetes Formulario de Conclusin para Personas con Diabetes 201  

E-print Network

Do Well, Be Well with Diabetes ­ 2013 1 Formulario de Conclusión para Personas con Diabetes Formulario de Conclusión para Personas con Diabetes ­ 201 Si usted NO TIENE diabetes, por favor NO LLENE este últimos cuatro números de mi número telefónico son __ __ __ __. C. Marque todas las clases sobre diabetes

124

Obtención de perfiles teóricos de elementos metálicos con velocidades macroscópicas  

NASA Astrophysics Data System (ADS)

El propósito de este trabajo es poder establecer -a partir de la modelización de perfiles de distintas especies- patrones de comparación observacional que permitan caracterizar los fenómenos físicos que están presentes en las estructuras que se observan. Para ello se resuelven las ecuaciones de equilibrio de ionización para un determinado átomo y una atmósfera de parámetros determinados. A partir de ello se definen las poblaciones para los distintos grados de ionización. Considerando distintas configuraciones e intensidades de flujos de masa se deducen la función fuente, el espesor óptico y se calculan los perfiles de las distintas líneas. Se obtuvieron perfiles teóricos de líneas del CII, CIV y del OIV para flujos entrante, saliente y pasante. La forma del perfil, las intensidades relativas entre los distintos flujos y el corrimiento Doppler da cuenta de una caracterización teórica a partir de la cual se comparará con observaciones.

Cirigliano, D.; Costa, A.; Rovira, M.

125

RoboCon: Operator interface for robotic applications  

SciTech Connect

Carnegie Mellon U. and ORNL`s Robotics and Process Systems Division are developing a state-of-the-art robot operator control station (RoboCon) with standardized hardware and software control interfaces to be adaptable to a variety of remote and robotic equipment currently funded by DOE`s Office of Science & Technology Robotics Technology Development Program. The human operation and telerobotic and supervisory control of sophisticated and remote and robotic systems is a complex, tiring, and non-intuitive activity. Since decontamination & decommissioning, selective equipment removal, mixed waste operations, and in-tank cleanup are going to be a major future activity in DOE environmental restoration and waste management cleanup agenda, it seems necessary to utilize an operator control station and interface which maximizes operator comfort and productivity.

Schempf, H.; Warwick, J.; Fung, M.; Chemel, B.; Blackwell, M.

1996-12-31

126

Neogene sequence stratigraphy, Nam Con Son Basin, offshore Vietnam  

SciTech Connect

An integrated well log, biostratigraphic, and seismic stratigraphic study of Miocene to Recent deltaic sediments deposited in the Nam Con Son Basin offshore from southern Vietnam shows the influence of eustacy and tectonics on sequence development. Sediments consist of Oligocene non-marine rift-basin fill (Cau Formation), early to middle Miocene tide-dominated delta plain to delta front sediments (TB 1.5 to TB 2.5, Due and Thong Formations), and late Miocene to Recent marine shelf sediments (TB. 2.6 to TB 3.1 0, Mang Cau, Nam Con Son, and Bien Dong Formations). Eustacy controlled the timing of key surfaces and sand distribution in the tectonically-quiet early Miocene. Tectonic effects on middle to late Miocene sequence development consist of thick transgressive systems tracts due to basin-wide subsidence and transgression, sand distribution in the basin center, and carbonate sedimentation on isolated fault blocks within the basin. Third-order sequence boundaries (SB) are identified by spore peaks, sand stacking patterns, and channel incision. In the basin center, widespread shale beds with coal occur above sequence boundaries followed by transgressive sandstone units. These TST sandstones merge toward the basin margin where they lie on older HST sandstones. Maximum flooding surfaces (MFS) have abundant marine microfossils and mangrove pollen, a change in sand stacking pattern, and often a strong seismic reflection with downlap. Fourth-order genetic-type sequences are also interpreted. The MFS is the easiest marker to identify and correlate on well logs. Fourth-order SB occur within these genetic units but are harder to identify and correlate.

McMillen, K.J. [Beaver Creek Tech. Co., Mason, TX (United States); Do Van Luu; Lee, E.K.; Hong, S.S. [PEDCO, Ho Chi Minh City (Viet Nam)

1996-12-31

127

Neogene sequence stratigraphy, Nam Con Son Basin, offshore Vietnam  

SciTech Connect

An integrated well log, biostratigraphic, and seismic stratigraphic study of Miocene to Recent deltaic sediments deposited in the Nam Con Son Basin offshore from southern Vietnam shows the influence of eustacy and tectonics on sequence development. Sediments consist of Oligocene non-marine rift-basin fill (Cau Formation), early to middle Miocene tide-dominated delta plain to delta front sediments (TB 1.5 to TB 2.5, Due and Thong Formations), and late Miocene to Recent marine shelf sediments (TB. 2.6 to TB 3.1 0, Mang Cau, Nam Con Son, and Bien Dong Formations). Eustacy controlled the timing of key surfaces and sand distribution in the tectonically-quiet early Miocene. Tectonic effects on middle to late Miocene sequence development consist of thick transgressive systems tracts due to basin-wide subsidence and transgression, sand distribution in the basin center, and carbonate sedimentation on isolated fault blocks within the basin. Third-order sequence boundaries (SB) are identified by spore peaks, sand stacking patterns, and channel incision. In the basin center, widespread shale beds with coal occur above sequence boundaries followed by transgressive sandstone units. These TST sandstones merge toward the basin margin where they lie on older HST sandstones. Maximum flooding surfaces (MFS) have abundant marine microfossils and mangrove pollen, a change in sand stacking pattern, and often a strong seismic reflection with downlap. Fourth-order genetic-type sequences are also interpreted. The MFS is the easiest marker to identify and correlate on well logs. Fourth-order SB occur within these genetic units but are harder to identify and correlate.

McMillen, K.J. (Beaver Creek Tech. Co., Mason, TX (United States)); Do Van Luu; Lee, E.K.; Hong, S.S. (PEDCO, Ho Chi Minh City (Viet Nam))

1996-01-01

128

Gleevec disminuye la recidiva del cáncer en pacientes con tumor estromal gastrointestinal primario  

Cancer.gov

Los resultados preliminares de un estudio clínico grande aleatorio y controlado con placebo, en pacientes con tumor estromal gastrointestinal (GIST) primario, un tipo de tumor que por lo general se encuentra en el estómago o en el intestino delgado, demostraron que los pacientes a los que se administró mesilato de imatinib (Gleevec®) luego de la extirpación total de su tumor tuvieron una probabilidad significativamente menor de padecer una recidiva del cáncer en comparación con aquellos a los que no se administró imatinib.

129

Relaciones filogenéticas de Euptychiina (Lepidoptera: Satyrinae) con base en características morfológicas de los adultos.  

E-print Network

??Marín Uribe, Mario Alejandro (2011) Relaciones filogenéticas de Euptychiina (Lepidoptera: Satyrinae) con base en características morfológicas de los adultos. Maestría thesis, Universidad Nacional de Colombia.… (more)

Marín Uribe, Mario Alejandro

2011-01-01

130

Courses: Economics (ECON) Page 291Sonoma State University 2010-2011 Catalog eCOn 321 lABOr eCOnOMiCS (4)  

E-print Network

resources and the control of pollution. Topics include: energy, water, minerals, forests, air pollution, Africa, Asia and ex-socialist economies. Prerequisite: ECON 303 or 304 or consent of instructor. eCOn 404

Ravikumar, B.

131

Non Invasive Biomedical Analysis. Breath Networking Session at PittCon 2011, Atlanta, Georgia Non Invasive Biomedical Analysis. Breath Networking Session at PittCon 2011, Atlanta, Georgia  

Microsoft Academic Search

Background This was the second year that our breath colleagues organized a networking session at the Pittsburgh Conference and Exposition, or 'PittCon' (www.pittcon.org\\/). This time it was called 'Non Invasive Biomedical Analysis' to broaden the scope a bit, but the primary focus remained on exhaled breath diagnostics. As reported last year in the Journal of Breath Research, PittCon continues to

Joachim D. Pleil

2011-01-01

132

Pros, Cons, and Alternatives to Weight Based Cost Estimating  

NASA Technical Reports Server (NTRS)

Many cost estimating tools use weight as a major parameter in projecting the cost. This is often combined with modifying factors such as complexity, technical maturity of design, environment of operation, etc. to increase the fidelity of the estimate. For a set of conceptual designs, all meeting the same requirements, increased weight can be a major driver in increased cost. However, once a design is fixed, increased weight generally decreases cost, while decreased weight generally increases cost - and the relationship is not linear. Alternative approaches to estimating cost without using weight (except perhaps for materials costs) have been attempted to try to produce a tool usable throughout the design process - from concept studies through development. This paper will address the pros and cons of using weight based models for cost estimating, using liquid rocket engines as the example. It will then examine approaches that minimize the impct of weight based cost estimating. The Rocket Engine- Cost Model (RECM) is an attribute based model developed internally by Pratt & Whitney Rocketdyne for NASA. RECM will be presented primarily to show a successful method to use design and programmatic parameters instead of weight to estimate both design and development costs and production costs. An operations model developed by KSC, the Launch and Landing Effects Ground Operations model (LLEGO), will also be discussed.

Joyner, Claude R.; Lauriem, Jonathan R.; Levack, Daniel H.; Zapata, Edgar

2011-01-01

133

iCons class at UMass brings together students from all scientific disciplines  

E-print Network

iCons class at UMass brings together students from all scientific disciplines Published: Wednesday called iCons - #12;Integrated Concentration in Science - a program that allows students from all from all scientific disciplines to work together on real-world problems. Petsch is having the students

Auerbach, Scott M.

134

Accesibilidad para personas con debilidad visual Mac OS X Snow Leopard  

E-print Network

Accesibilidad para personas con debilidad visual Mac OS X Snow Leopard ASIC ­ 18 de noviembre de 2010 Pág. 1 de 25 GUÍA DE ACCESIBILIDAD PARA PERSONAS CON DEBILIDAD VISUAL EN ENTORNO MAC OS X SNOW LEOPARD Al igual que otros sistemas operativos, MAC OS X Snow Leopard ofrece algunas ayudas para que las

Fernández de Córdoba, Pedro

135

SURGIMIENTO Y DESARROLLO DE LA COMUNICACIÓN ORGANIZACIONAL Y SU RELACIÓN CON OTRAS CIENCIAS  

Microsoft Academic Search

El lenguaje nace como la conciencia, de la necesidad, de los apremios de relación con los demás hombres… La conciencia de la necesidad de entablar relaciones con los individuos circundantes es el comienzo de la conciencia de que el hombre vive, en general, dentro de una sociedad… La conciencia por tanto, es ya de antemano un producto social, y lo

Maria del Carmen Torres Alonso; José Alberto Alejo Becerra

2011-01-01

136

La salud en personas con discapacidad intelectual en España: estudio europeo POMONA-II  

PubMed Central

Introducción Estudios internacionales demuestran que existe un patrón diferenciado de salud y una disparidad en la atención sanitaria entre personas con discapacidad intelectual (DI) y población general. Objetivo Obtener datos sobre el estado de salud de las personas con DI y compararlos con datos de población general. Pacientes y métodos Se utilizó el conjunto de indicadores de salud P15 en una muestra de 111 sujetos con DI. Los datos de salud encontrados se compararon según el tipo de residencia de los sujetos y se utilizó la Encuesta Nacional de Salud 2006 para comparar estos datos con los de la población general. Resultados La muestra con DI presentó 25 veces más casos de epilepsia y el doble de obesidad. Un 20% presentó dolor bucal, y existió una alta presencia de problemas sensoriales, de movilidad y psicosis. Sin embargo, encontramos una baja presencia de patologías como la diabetes, la hipertensión, la osteoartritis y la osteoporosis. También presentaron una menor participación en programas de prevención y promoción de la salud, un mayor número de ingresos hospitalarios y un uso menor de los servicios de urgencia. Conclusiones El patrón de salud de las personas con DI difiere del de la población general, y éstas realizan un uso distinto de los servicios sanitarios. Es importante el desarrollo de programas de promoción de salud y de formación profesional específicamente diseñados para la atención de personas con DI, así como la implementación de encuestas de salud que incluyan datos sobre esta población. PMID:21948011

Martínez-Leal, Rafael; Salvador-Carulla, Luis; Gutiérrez-Colosía, Mencía Ruiz; Nadal, Margarida; Novell-Alsina, Ramón; Martorell, Almudena; González-Gordón, Rodrigo G.; Mérida-Gutiérrez, M. Reyes; Ángel, Silvia; Milagrosa-Tejonero, Luisa; Rodríguez, Alicia; García-Gutiérrez, Juan C.; Pérez-Vicente, Amado; García-Ibáñez, José; Aguilera-Inés, Francisco

2011-01-01

137

Elizabeth A.Johnson y Kefyn M.Catley con ilustraciones de Patricia J. Wynne  

E-print Network

Vidaen la Hojarasca La Elizabeth A.Johnson y Kefyn M.Catley con ilustraciones de Patricia J. Wynne Elizabeth A. Johnson y Kefyn M. Catley con ilustraciones de Patricia J. Wynne Ellen V. Futter, Presidente personal y voluntarios del CBC Escrito por: Elizabeth A. Johnson (Center for Biodiversity and Conservation

138

Per: Chirapaq celebra 25 aos con un foro sobre "Derechos de los Pueblos Indgenas"  

E-print Network

Perú: Chirapaq celebra 25 años con un foro sobre "Derechos de los Pueblos Indígenas celebrará su 25 aniversario con el foro público internacional: "Derechos de los Pueblos Indígenas: Avances y la Nación Cree, ex parlamentario y miembro del Mecanismo de Expertos sobre los Derechos de los

Islas, León

139

Context reasoning is the process of drawing con-clusions from existing context information, and is  

E-print Network

Abstract Context reasoning is the process of drawing con- clusions from existing context information, and is considered crucial to geospatial interoperability. However, such reasoning still remains and mod- eling the external quality (fitness-for-use) of con- text information is important for reasoning

140

Cursos Oficiales ETSII-URJC Obtn tu Diploma con los nuevos cursos de  

E-print Network

REST con Spring MVC MongoDB Spring Data Testing Servicios cloud computing: APIs REST para aplicaciones web y móviles con Spring y MongoDB Del 20 de marzo al 4 de abril, de 13 a 15h Duración: 20 horas

Rey Juan Carlos, Universidad

141

Almost-Flat Line Con gurations Department of Industrial Sciences and Technology  

E-print Network

Communications, Robot Kinematics, e.a.). In order to classify the con#12;gurations of n lines in real (a). This is called the planar layout of the con#12;gurations. So, in a planar layout one line can \\cross over" or \\cross under" or intersect another line. The char- acterization of the possible planar layouts of n lines

Penne, Rudi

142

Persisten las diferencias de cáncer de seno en hispanas con el mismo acceso a la atención médica  

Cancer.gov

Con el mismo acceso a servicios médicos, persisten las diferencias en cuanto al tamaño, el estadio y el grado del cáncer de seno en las mujeres hispanas en comparación con las mujeres blancas no hispanas.

143

Global Environmental Change 11 (2001) 69}78 Sahel pastoralists: opportunism, struggle, con#ict and negotiation.  

E-print Network

Global Environmental Change 11 (2001) 69}78 Sahel pastoralists: opportunism, struggle, con#ict in to insure access to resources; to the nature of con#icts and co-operation between ethnic groups and pasture, culminating in present-day tensions and con#ict between pastoral groups. State development e

Batterbury, Simon

144

Determination of composition in stoichiometric Co-N ultrathin films by nitrogen plasma sputtering  

SciTech Connect

This work utilizes low-energy sputtering to incorporate the generated nitrogen plasma into an epitaxial 1.4 nm Co film on the surface of a ZnO(002) substrate. In this method, ultrathin Co-N amorphous films were formed. Interestingly, Co is key to the formation of Co-N films. Without the deposition of Co on the ZnO(002), nitride films cannot be formed. Observations of the surface composition of the Co-N films after the firing of a N{sup +} ion beam onto it demonstrated that the surface concentration of Co reduced at the same rate as the reduction in the concentration of N upon successive sputtering. Theoretical calculations based on the Auger peak-to-peak amplitudes established that the composition of the amorphous Co-N thin films may be Co{sub 3}N{sub 2}.

Su, C. W.; Huang, M. S.; Chang, Y. C.; Tsai, T. H. [Department of Applied Physics, National Chiayi University, 300 Syuefu Rd., Chiayi 60004, Taiwan (China); Lee, Y. H.; Lee, J. C. [Department of Physics, National Cheng Kung University, 1 University Rd., Tainan 70101, Taiwan (China)

2009-02-01

145

El tratamiento con cloro es un mtodo para desinfectar un pozo de agua. Se recomien-  

E-print Network

exceso de lluvia entran en el pozo. Si el agua subterránea constituye en sí la fuente de bacterias, elEl tratamiento con cloro es un método para desinfectar un pozo de agua. Se recomien- da cuando un sistema de agua está contam- inado con bacterias. La contaminación puede ocurrir en la instalación del

146

EyeCon -- a motion sensing tool for creating interactive dance, music and video projections  

Microsoft Academic Search

EyeCon is a video-based motion sensing system which allows performers to generate or control music and projected images through their movements and gestures in space. It was developed Frieder Weiß as an application- driven project of the Palindrome inter-media performance group and is thus more a tool for artists than for researchers. EyeCon does, however, allow motion sensing according to

Robert Wechsler; Peter Dowling

147

Quimioterapia de alta dosis prolonga en forma significativa la supervivencia en pacientes con leucemia mieloide aguda  

Cancer.gov

Los resultados preliminares de un estudio clínico grande con asignación al azar de pacientes de 16 a 60 años de edad con leucemia mieloide aguda (LMA), un cáncer de la sangre y de la médula ósea, que no había sido tratada anteriormente, muestran que los pacientes que recibieron una alta dosis de daunorrubicina, un fármaco de quimioterapia disponible comercialmente, durante la terapia inicial vivieron más que los pacientes que recibieron una dosis normal del mismo fármaco.

148

NSF funds iCons and HCC interdisciplinary renewable energy labs The campus' Integrated Concentration in Science (iCons) program and  

E-print Network

NSF funds iCons and HCC interdisciplinary renewable energy labs The campus' Integrated in integrative education with an emphasis on current societal problems to create the renewable energy laboratory-of-the- art renewable energy laboratory courses at both institutions thanks to $250,000 in National Science

Auerbach, Scott M.

149

Virulence, Speciation and Antibiotic Susceptibility of Ocular Coagualase Negative Staphylococci (CoNS)  

PubMed Central

Background: Coagulase negative Staphylococci (CoNS) are common inhabitants of human skin and mucous membranes. With the emergence of these organisms as prominent pathogens in patients with ocular infections, investigation has intensified in an effort to identify important virulence factors and to inform new approaches to treatment and prevention. Aim: To isolate CoNS from ocular specimens; to study the possible virulence factors; speciation of coagulase negative staphylococci (CoNS) which were isolated from ocular complications; antibiotic susceptibility testing of ocular CoNS. Materials and Methods: The specimens were collected from the target patients who attended the Microbiology Laboratory of a tertiary care eye hospital in Coimbatore, Tamilnadu state, India. The isolates were subjected to tube and slide coagulase tests for the identification of CoNS. All the isolates were subjected to screening for lipase and protease activities. Screening for other virulence factors viz., slime production on Congo red agar medium and haemagglutination assay with use of 96-well microtitre plates. These isolates were identified upto species level by performing biochemical tests such as phosphatase test, arginine test, maltose and trehalose fermentation tests and novobiocin sensitivity test. The isolates were subjected to antibiotic susceptibility studies, based on the revised standards of Clinical and Laboratory Standards Institutes (CLSI). Results: During the one year of study, among the total 260 individuals who were screened, 100 isolates of CoNS were obtained. Lipolytic activity was seen in all the isolates, whereas 38 isolates showed a positive result for protease. A total of 63 isolates showed slime production. Of 100 isolates, 30 isolates were analyzed for haemagglutination, where 4 isolates showed the capacity to agglutinate the erythrocytes. The results of the biochemical analysis revealed that of the 100 isolates of CoNS, 43% were Staphylococcus epidermidis. The other isolates were identified as S. xylosus (n=8), S. captis (n=16), S. haemolyticus (n=10), S. saccharolyticus (n=2), S. hominis (n=5), S. saprophyticus (n=6) and S. intermedius (n=1). On the other hand, 9 isolates were not identified. In the antibiotic susceptibility analysis, it was found that most of the isolates were sensitive to vancomycin, amikacin and linczolid and resistant to cefatoxime, oxacillin, bacitracin and nalidixic acid. Conclusion: S. epidermidis was found to be predominant in causing the ocular complications. Slime production, heamagglutination, protease and lipase activities could be the putative virulence factors of CoNS. Antibiotic susceptibility patterns of CoNS against antibacterial agents revealed maximum resistance to beta lactam groups, and the resistance was found to be higher to oxacillin, and lowest to vancomycin. PMID:24995181

Priya, Ravindran; Mythili, Arumugam; Singh, Yendremban Randhir Babu; Sreekumar, Haridas; Manikandan, Palanisamy; Panneerselvam, Kanesan

2014-01-01

150

Structural basis of ConM binding with resveratrol, an anti-inflammatory and antioxidant polyphenol.  

PubMed

Resveratrol can also inhibit the activation of proinflammatory mediators and cytokines at the early gene expression stage. It is well known that lectins are sugar-binding proteins that act as both pro- and anti-inflammatory molecules. Thus, the objective of this work was to verify the binding of a polyphenol compound with a lectin of Canavalia maritima (ConM) based on their ability to inhibit pro-inflammatory processes. To accomplish this, ConM was purified and crystallized, and resveratrol was soaked at 5mM for 2h of incubation. The crystal belongs to the monoclinic space group C2, the final refinement resulted in an Rfactor of 16.0% and an Rfree of 25.5%. Resveratrol binds in the rigid ?-sheet through H-bonds and hydrophobic interaction with amino acids that compose the fifth and sixth ?-strands of the rigid ?-sheet of ConM. The ConM and resveratrol inhibited DPPH oxidation, showing synergic activity with the most effective ratio of 2:3 and carbohydrate binding site is not directly related to antioxidant activity. It is the interaction between ConM and resveratrol that indicates the synergism of these two molecules in acting as free radicals scavengers and in reducing the inflammatory process through the inhibition of many pro-inflammatory events. PMID:25192853

Rocha, Bruno A M; Teixeira, Claudener S; Silva-Filho, José C; Nóbrega, Raphael B; Alencar, Daniel B; Nascimento, Kyria S; Freire, Valder N; Gottfried, Carmem J S; Nagano, Celso S; Sampaio, Alexandre H; Saker-Sampaio, Silvana; Cavada, Benildo S; Delatorre, Plínio

2015-01-01

151

ConSole: using modularity of Contact maps to locate Solenoid domains in protein structures  

PubMed Central

Background Periodic proteins, characterized by the presence of multiple repeats of short motifs, form an interesting and seldom-studied group. Due to often extreme divergence in sequence, detection and analysis of such motifs is performed more reliably on the structural level. Yet, few algorithms have been developed for the detection and analysis of structures of periodic proteins. Results ConSole recognizes modularity in protein contact maps, allowing for precise identification of repeats in solenoid protein structures, an important subgroup of periodic proteins. Tests on benchmarks show that ConSole has higher recognition accuracy as compared to Raphael, the only other publicly available solenoid structure detection tool. As a next step of ConSole analysis, we show how detection of solenoid repeats in structures can be used to improve sequence recognition of these motifs and to detect subtle irregularities of repeat lengths in three solenoid protein families. Conclusions The ConSole algorithm provides a fast and accurate tool to recognize solenoid protein structures as a whole and to identify individual solenoid repeat units from a structure. ConSole is available as a web-based, interactive server and is available for download at http://console.sanfordburnham.org. PMID:24766872

2014-01-01

152

ConA-based glucose sensing using the long-lifetime azadioxatriangulenium fluorophore  

NASA Astrophysics Data System (ADS)

Fluorescent glucose sensing technologies have been identified as possible alternatives to current continuous glucose monitoring approaches. We have recently introduced a new, smart fluorescent ligand to overcome the traditional problems of ConA-based glucose sensors. For this assay to be translated into a continuous glucose monitoring device where both components are free in solution, the molecular weight of the smart fluorescent ligand must be increased. We have identified ovalbumin as a naturally-occurring glycoprotein that could serve as the core-component of a 2nd generation smart fluorescent ligand. It has a single asparagine residue that is capable of displaying an N-linked glycan and a similar isoelectric point to ConA. Thus, binding between ConA and ovalbumin can potentially be monovalent and sugar specific. This work is the preliminary implementation of fluorescently-labeled ovalbumin in the ConA-based assay. We conjugate the red-emitting, long-lifetime azadioxatriangulenium (ADOTA+) dye to ovalbumin, as ADOTA have many advantageous properties to track the equilibrium binding of the assay. The ADOTA-labeled ovalbumin is paired with Alexa Fluor 647-labeled ConA to create a Förster Resonance Energy Transfer (FRET) assay that is glucose dependent. The assay responds across the physiologically relevant glucose range (0-500 mg/dL) with increasing intensity from the ADOTA-ovalbumin, showing that the strategy may allow for the translation of the smart fluorescent ligand concept into a continuous glucose monitoring device.

Cummins, Brian; Simpson, Jonathan; Gryczynski, Zygmunt; Sørensen, Thomas Just; Laursen, Bo W.; Graham, Duncan; Birch, David; Coté, Gerard

2014-02-01

153

Estudios estructurales sobre entidades tiosemicarbazonacobre(II) y su interacción con polioxometalatos y biomoléculas: síntesis, estabilidad y propiedades magnéticas.  

E-print Network

??Estudios estructurales sobre entidades tiosemicarbazonacobre(II) y su interacción con polioxometalatos y biomoléculas. Síntesis, estabilidad y propiedades magnéticas? El presente Trabajo ahonda en la síntesis y… (more)

Gil García, Rubén

2012-01-01

154

Estrategia de aula para alcanzar aprendizajes significativos y desarrollar habilidades de pensamiento científico en relación con la meiosis.  

E-print Network

??Villada Salazar, Claudia Patricia (2011) Estrategia de aula para alcanzar aprendizajes significativos y desarrollar habilidades de pensamiento científico en relación con la meiosis. Maestría thesis,… (more)

Villada Salazar, Claudia Patricia

2011-01-01

155

Un estudio financiado por los Institutos Nacionales de la Salud (NIH) muestra reducción en la mortalidad entre hombres con cáncer de próstata en grado intermedio:  

Cancer.gov

Terapia hormonal por corto tiempo administrada en combinación con radioterapia a hombres con cáncer de próstata en estadio inicial aumentó sus posibilidades de vivir más en comparación con tratamiento de radioterapia sola, según un estudio clínico patrocinado por el NCI. Los beneficios del tratamiento combinado se limitaron principalmente a pacientes con enfermedad de riesgo intermedio y no se observaron en hombres con cáncer de próstata de riesgo bajo, indican los investigadores.

156

Zoning administrators and others con-cerned with airport land use will soon  

E-print Network

Zoning administrators and others con- cerned with airport land use will soon have help when it comes to making decisions that affect their airports. The recently completed Airport Land Use zoning stan- dards, local ordinances, and land use. The manual was developed by the Minnesota Department

Minnesota, University of

157

Costo de capital con costo del patrimonio apalancado como el riesgo de los escudos fiscales  

Microsoft Academic Search

Se presenta la derivación de costo de capital bajo la premisa del ahorro de impuestos de riesgo descuento con el costo de capital apalancado. Se demuestra que la formulación es coherente y se deriva de los principios financieros básicos. Esta formulación es válida para los flujos de caja finitos y perpetuidades sin crecimiento. Además, se puede calcular sin la circularidad

Joseph Tham; Ignacio Velez Pareja

2010-01-01

158

Timectomía por videotoracoscopia asistida con bloqueo anestésico paravertebral bilateral en pacientes miasténicos  

Microsoft Academic Search

Summary Thymectomy continues to be the treatment of choice for certain patients with myasthenia gravis. As surgical techniques have developed, anesthesiologists have con- sidered the need to adapt anesthetic techniques to improve care of patients undergoing this procedure. We describe the anesthetic management of 2 patients under- going thymectomy performed with a bilateral thoracos- copic approach. Because it is best

J. L. López-Berlanga; I. Garutti; E. Martínez-Campos; P. Piñeiro; D. Salvatierra

159

Science for conServation 293 Loss of genetic diversity and  

E-print Network

Science for conServation 293 Loss of genetic diversity and inbreeding in New Zealand's threatened of Conservation. This paper may be cited as: Jamieson, I.G. 2009: Loss of genetic diversity and inbreeding in New bird species #12;Loss of genetic diversity and inbreeding in New Zealand's threatened bird species Ian

Jamieson, Ian

160

Integrated Concentration in Science, 2012 High Fructose Corn Syrup a mini iCons case study  

E-print Network

© Integrated Concentration in Science, 2012 High Fructose Corn Syrup­ a mini iCons case study researchers find that high fructose corn syrup prompts considerably more weight gain. http://www.princeton.edu/main/news/archive/S26/91/22K07/ The Atlantic, Aug 13, 2012 ­ Study: High fructose corn syrup no worse than `real' sugar

Auerbach, Scott M.

161

Safety and Toxicity Evaluation of GonaCon ™ Immunocontraceptive Vaccine in White-Tailed Deer  

Microsoft Academic Search

GonaCon ™ Immunocontraceptive Vaccine targets the reproductive hormone gonadotropin releasing hormone (GnRH) secreted by the hypothalamus of the brain. Antibodies produced in response to the vaccine inactivate endogenous GnRH, which in turn eliminates stimulation of the pituitary gland and gonads in males or females. The resulting \\

Gary Killian; Donald Wagner; Richard Engeman; Lowell Miller

162

On the Detection of Con icts in Diagnostic Bayesian Networks Using Abstraction  

E-print Network

On the Detection of Con icts in Diagnostic Bayesian Networks Using Abstraction Young-Gyun Kim Bayesian net- work (the base model) and constructs, with- out assistance, a bipartite network to be used and imple- mented. 1 INTRODUCTION Developing a diagnostic expert system that uses a Bayesian network

Valtorta, Marco

163

CecileBernard La escasez de alimentos que. con distinto gr&o. afectz a  

E-print Network

-,- .e CI' I CecileBernard La escasez de alimentos que. con distinto gr&o. afectz a la mayoría de respecta al abasto de alimentos, se reactiva una institución creada en 1965, la CONASUPO (CompaFh Na alimentos principales (tortillas, enva- sado de la leche), monopoliode la importación de granos (M. Durand

Paris-Sud XI, Université de

164

La fecha ltima en que el alimento se debe La mayora de los alimentos pueden con-  

E-print Network

La fecha última en que el alimento se debe vender. ****************************************** La mayoría de los alimentos pueden con- sumirse después de esta fecha, SI han sido manejados y guardados bolsas). ****************************************** No compre alimentos después de la fecha "véndase

165

Una entrevista con Inés Margarita Stranger (Chile) y sus personajes femeninos  

E-print Network

FALL 1996 89 Una entrevista con Inés Margarita Stranger (Chile) y sus personajes femeninos Pedro Bravo-Elizondo A la fecha, su vida contempla un título como teatrista por la Universidad Católica de Chile en la cual es profesora en la Escuela de...

Bravo-Elizondo, Pedro

1996-10-01

166

Onion Routing Access Con gurations Paul F. Syverson, Michael G. Reed, and David M. Goldschlag  

E-print Network

Onion Routing Access Con gurations Paul F. Syverson, Michael G. Reed, and David M. Goldschlag Naval Research Laboratory Abstract Onion Routing is an infrastructure for private com- munication over and tra c analysis. Thus it hides not only the data being sent, but who is talking to whom. Onion Routing

167

Impactos del Huracn Isaac en la calidad del agua en Luisiana con MODIS 250m  

E-print Network

lluvias. Por tal razón se quiere estudiar la calidad del agua en el delta del río Mississippi antes1 Impactos del Huracán Isaac en la calidad del agua en Luisiana con MODIS 250m Thais J. Alicea imágenes en ENVI. Palabras clave: Calidad del agua, ENVI, Isaac, Luisiana, MODIS

Gilbes, Fernando

168

Although most Minnesota airports do not have much concrete pavement, the con-  

E-print Network

Although most Minnesota airports do not have much concrete pavement, the con- crete they do have are generally constructed out of concrete that is much thicker. Maintaining any section of pavement, regardless of its size, is important for pre- serving its condition and optimizing pave- ment life. Pavement

Minnesota, University of

169

Iron formations are typically thinly bed-ded or laminated sedimentary rocks con-  

E-print Network

222 ABSTRACT Iron formations are typically thinly bed- ded or laminated sedimentary rocks con- taining 15% or more of iron and a large pro- portion of silica (commonly >40%). In the ca. 2590­2460 Ma Campbellrand-Kuruman Complex, Transvaal Supergroup, South Africa, iron formation occurs as a sediment- starved

Fischer, Woodward

170

ANALISI DEL DANNEGGIAMENTO SU COMPONENTI IN MATERIALE COMPOSITO CON TECNICA TERMOELASTICA  

Microsoft Academic Search

Sommario Il largo e crescente utilizzo di materiali compositi in applicazioni ingegneristiche di estrema importanza, quali ad esempio quelle aerospaziali, ha posto l'attenzione su tecniche, come quella termoelastica, che consentono una valutazione delle sollecitazioni rapida e a campo intero. Parallelamente risulta di estremo interesse la valutazione dell'integrità strutturale del componente in esame mediante controlli non distruttivi come quelli con ultrasuoni

U. Galietti; C. Pappalettere

2009-01-01

171

The Value of Literacy Beyond Reading: Empowering Adult Women Through Knowledge and Con...dence  

E-print Network

The Value of Literacy Beyond Reading: Empowering Adult Women Through Knowledge and Con funded by the Social Science Research Council of Canada. 1 #12;Abstract Adult female literacy around the world to institute large scale adult literacy programs. However, evidence on the e

Bandyopadhyay, Antar

172

La Universidad de Alicante coordina un nuevo proyecto Erasmus Mundus con 21 universidades  

E-print Network

entre las universidades europeas que ha obtenido financiación externa para la movilidad e intercambio de, gracias a un nuevo proyecto denominado "Proyecto de Movilidad Transeuropea sobre la Educación para el Arquitectura. El proyecto contará con un presupuesto de 3.508.975 de euros y ofrecerá 212 becas de movilidad

Escolano, Francisco

173

Hand Detection on Sign Language Videos Zhong Zhang, Christopher Conly, and Vassilis Athitsos  

E-print Network

Hand Detection on Sign Language Videos Zhong Zhang, Christopher Conly, and Vassilis Athitsos.zhang@mavs.uta.edu, cconly@uta.edu, athitsos@uta.edu ABSTRACT For gesture and sign language recognition, hand shape and hand an efficient and reliable hand detector is therefore an important step in recognizing signs and gestures

Athitsos, Vassilis

174

Con il patrocinio di / Sponsored by IRCCS, Santa Lucia Foundation, Roma  

E-print Network

Neuroscience and society Marzo / March 11-13, 2013, Rome Cognitive and Social Neuroscience Laboratory da un Neuroscienze Sociali e Cognitive / Speakers from Social and Cognitive Neuroscience Lab: o Enea Francesco Pavone dopo stimolazione del volto in persone con lesione al midollo spinale" - "The rubber hand illusion

Di Pillo, Gianni

175

LA PSICOLOGÍA ORGANIZACIONAL, VÍNCULO CON EL PROCESO DE PREVENCIÓN SOCIAL EN EL MUNICIPIO JESUS MENÉNDEZ  

Microsoft Academic Search

Con el objetivo de mejorar los resultados en la labor de prevención y atención social en el municipio Jesús Menéndez, contribuir al perfeccionamiento de la gestión institucional de las organizaciones laborales en el territorio y fortalecer la pertinencia de la carrera de Licenciatura en Psicología de la Sede Universitaria Municipal Jesús Menéndez, se adecuan los programas de estudio de la

Aliek Méndez Bordón; Marlene Goytizolo Andreus

2012-01-01

176

Abstract A model of "distributed cognition" is con-trasted with the "mental representation" model exempli-  

E-print Network

Abstract A model of "distributed cognition" is con- trasted with the "mental representation" model exempli- fied by Tomasello and Call's Primate Cognition. Rather than using behavior as a basis interactions as, themselves, directly observable cognitive events. Similar to a Vygotskian ap- proach

Kirsh, David

177

Mul$-scale Demand-Side Management for Con$nuous Power-intensive Processes  

E-print Network

and uncertainty in prices · Timing and produc(on quan((es (DR)* · Inventory management inventory facilitate performing Demand-side Management (DSM) at air separa$on plants1 Mul$-scale Demand-Side Management for Con$nuous Power-intensive Processes

Grossmann, Ignacio E.

178

Salud con Sabor Latino: a culturally sensitive obesity prevention curriculum in an underserved Latino community  

Microsoft Academic Search

Salud con Sabor Latino is a culturally sensitive obesity prevention curriculum that incorporates the traditions and values of the Latino community and family. The 4-week curriculum meets twice a week and includes an education and cooking component. Key components of the curriculum are portion size, reading food labels, taking small steps, eating a variety of foods, and the importance of

Christina Araiza; Maria Valenzuela; Bonnie Gance-Cleveland

2012-01-01

179

Formulación de alimentos para celíacos con base en mezclas de harinas de quínoa, cereales y almidones  

Microsoft Academic Search

RESUMEN. Se formularon alimentos sin gluten para celíacos en base a mezclas de harina de quínoa (Chenopodium quinoa), arroz y maíz con almidones. Para la formulación de estos alimentos se usó la herramienta informática (ALIM V1.0) desarrollada por los auto- res. Se obtuvieron panqueques, scones, prepizza y pan, los cuales fueron evaluados en composición química (proteínas, grasas, ceni- zas, fibras,

Valeria Del Castillo; Gerardo Lescano; Margarita Armada

180

DIGITAL.CSIC: "Catalogacin con Dublin Core, gestin de derechos de  

E-print Network

DIGITAL.CSIC: "Catalogación con Dublin Core, gestión de derechos de autor y permisos de editores;Copyright y el acceso abierto #12;¿De qué estamos hablando? · Derechos de autor: conjunto de normas y principios que regulan los derechos morales y patrimoniales que la ley concede a los autores por el solo

181

Accordo con il Teatro Nuovo di Milano Stagione 2009/10 Destinatari  

E-print Network

dell'Università degli Studi di Milano con tesserino UNIMI e documento d'identità, sino ad esaurimento diritto, ad un biglietto ridotto del 50% sul biglietto intero del settore poltrona, per il titolare ed un incontra l'anima del Gospel. da mar. 29 dicembre 2009 a Loretta Goggi S.P.A. mer. 06 gennaio

De Cindio, Fiorella

182

Medidas antropométricas como predictores del comportamiento lipídico sérico en adolescentes con síndrome de Down  

Microsoft Academic Search

Current findings suggest that more attention needs to be gi- ven to the increase in body mass being achieved by disabled populations in general and individuals with mental retarda- tion in particular, to minimize long-term negative health con- sequences. Given that physical activity programs have been reported as one of the most effective ways of improving the health of individuals

Francisco Javier Ordóñez-Munoz; Manuel Rosety-Rodríguez; Jesús María Rosety-Rodríguez; Manuel Rosety-Plaza

183

Pros and Cons of Teaching Reading to Four- and Five-Year-Olds.  

ERIC Educational Resources Information Center

There are many pros and cons to the recent trend of early reading. The opponents fear that too much emphasis on early reading may lead to a less rounded development of the child; they agree on providing the child with richer and more varied experiences to insure reading readiness. The advocates believe that today's children have already had more…

Ollila, Lloyd O.

184

Annotating Web Images using NOVA: NOn-conVex group College of Computer Science,  

E-print Network

Annotating Web Images using NOVA: NOn-conVex group spArsity Fei Wu College of Computer Science, NOVA is the first to introduce non-convex penalty for group selection in high-dimensional heterogeneous it uses non-convex penalty, it achieves the consistency. We demonstrate the superior performance of NOVA

Rui, Yong

185

Violación del Principio de Equivalencia en Teorías con Dilatón de Cuerdas  

Microsoft Academic Search

Se estudian las violaciones al Principio de Equivalencia en Teorías con Dilatón de Cuerdas. En estos modelos, algunas de las constantes fundamentales dependen del espacio y del tiempo. Se muestra que los experimentos de caída libre no tienen aún precisión como para poner límites a los parámetros de la teoría.

S. J. Landau; P. D. Sisterna; H. Vucetich

2003-01-01

186

Non Invasive Biomedical Analysis - Breath Networking Session at PittCon 2011, Atlanta, Georgia  

EPA Science Inventory

This was the second year that our breath colleagues organized a networking session at the Pittsburgh Conference and Exposition or ''PittCon'' (http://www.pincon.org/).This time it was called "Non-invasive Biomedical Analysis" to broaden the scope a bit, but the primary focus rema...

187

conStruction MAnAgeMent College of Rural and Community Development  

E-print Network

The construction management program meets growing needs in the con- struction industry by training entry to the largest of skyscrapers and industrial projects; and on rural roads to major highways. Construction principles of busi- ness and know about the technical aspects of the construction industry. Graduates

Hartman, Chris

188

DESign AnD conStruction College of Engineering and Mines  

E-print Network

in the construction industry. The program was designed in collaboration with construction industry em- ployers and continues to engage industry as a partner in the program. Engineers and other construction professionalsDESign AnD conStruction MAnAgEMEnt College of Engineering and Mines Department of Civil

Hartman, Chris

189

INTRODUCTION Recent studies have demonstrated that resting state fMRI (rs-fMRI) con-  

E-print Network

INTRODUCTION Recent studies have demonstrated that resting state fMRI (rs-fMRI) con- nectivity to the need for: (1) a training dataset, (2) a-priori information about informative connections, and a (3 PROCESSING AT THE SINGLE SUBJECT LEVEL USING WHOLE-BRAIN FMRI CONNECTIVITY METHODS ( Experimental Paradigm

Bandettini, Peter A.

190

Enrichment of Glycoproteins using Nano-scale Chelating Con A Monolithic Capillary Chromatography  

PubMed Central

Immobilized lectin chromatography can be employed for glycoprotein enrichment, but commonly used columns have limitations of yield and resolution. In order to improve efficiency and to make the technique applicable to minimal sample material, we have developed a nano-scale chelating Concanavalin A (Con A) monolithic capillary prepared using GMA-EDMA (glycidyl methacrylate–co-ethylene dimethacrylate) as polymeric support. Con A was immobilized on Cu(II)-charged iminodiacetic acid (IDA) regenerable sorbents by forming a IDA:Cu(II):Con A sandwich affinity structure that has high column capacity as well as stability. When compared with conventional Con A lectin chromatography, the monolithic capillary enabled the better reproducible detection of over double the number of unique N-glycoproteins in human urine samples. Utility for analysis of minimal biological samples was confirmed by the successful elucidation of glycoprotein profiles in mouse urine samples at the microliter scale. The improved efficiency of the nano-scale monolithic capillary will impact the analysis of glycoproteins in complex biological samples, especially where only limited material may be available. PMID:19366252

Feng, Shun; Yang, Na; Pennathur, Subramaniam; Goodison, Steve; Lubman, David M.

2009-01-01

191

Adsornftl 8~f^Ll* ORNL/CON-155 O173IS1o COp  

E-print Network

of Stirling Engine Thermodynamics N. C. J. Chen F. P. Griffin C. D. West OPERATED BY TAHP *MARTIN MARIETTA Government or any agency thereof. #12;ORNL/CON-155 LINEAR HARMONIC ANALYSIS OF STIRLING ENGINE THERMODYNAMICS ................... 8 2.3 Integrated Energy Equations ......................... 11 2.4 Engine Performance Parameters

Oak Ridge National Laboratory

192

The crystal structures of the calcium-bound con-G and con-T[K7gamma] dimeric peptides demonstrate a metal-dependent helix-forming motif.  

PubMed

Short peptides that have the ability to form stable alpha-helices in solution are rare, and a number of strategies have been used to produce them, including the use of metal chelation to stabilize folding of the backbone. However, no example exists of a structurally well-defined helix stabilized exclusively through metal ion chelation. Conantokins (con)-G and -T are short peptides that are potent antagonists of N-methyl-D-aspartate receptor channels. While con-G exhibits no helicity alone, it undergoes a structural transition to a helical conformation in the presence of a variety of multivalent cations, especially Mg2+ and Ca2+. This complexation also results in antiparallel dimerization of two peptide helices in the presence of Ca2+, but not Mg2+. A con-T variant, con-T[K7gamma], displays very similar behavior. We have solved the crystal structures of both Ca2+/con-G and Ca2+/con-T [K7gamma] at atomic resolution. These structures clearly show the nature of the metal-dependent dimerization and helix formation and surprisingly also show that the con-G dimer interface is completely different from the con-T[K7gamma] interface, even though the metal chelation is similar in the two peptides. This represents a new paradigm in helix stabilization completely independent of the hydrophobic effect, which we define as the "metallo-zipper." PMID:17243678

Cnudde, Sara E; Prorok, Mary; Dai, Qiuyun; Castellino, Francis J; Geiger, James H

2007-02-14

193

Deutsche Bank Deutsche Bank S.p.A. la consociata italiana di Deutsche Bank AG che, con oltre  

E-print Network

Deutsche Bank Deutsche Bank S.p.A. è la consociata italiana di Deutsche Bank AG che, con oltre 100.000 collaboratori in più di 72 Paesi nel mondo, vanta più di 24 milioni di clienti. Deutsche Bank ricerca brillanti laureati con ottime capacità relazionali, realizzative e cognitive. Posizione Addetto Personal Banking

Robbiano, Lorenzo

194

76 FR 54533 - Pipeline Safety: Issuance of Draft Decision on GexCon US, Inc. Petition for Approval of Flame...  

Federal Register 2010, 2011, 2012, 2013

...Decision on GexCon US, Inc. Petition for Approval of Flame Acceleration Simulator AGENCY: Pipeline and Hazardous Materials Safety...Decision on GexCon US, Inc.'s petition for approval of Flame Acceleration Simulator (FLACS). The Draft Decision is available...

2011-09-01

195

Añadir quimioterapia después de la radioterapia mejora la supervivencia de adultos con un tipo de tumor cerebral de crecimiento lento  

Cancer.gov

Adultos con gliomas de grado bajo, una forma de tumor cerebral, que recibieron tratamiento con quimioterapia después de la radioterapia vivieron más tiempo que pacientes que recibieron solo radioterapia, según los resultados de seguimiento a largo plazo de un estudio clínico aleatorizado y controlado, subvencionado por los NIH.

196

Comparacion internacional del gasto publico en Sanidad y Educacion de España con los paises de la OCDE 1982-96  

Microsoft Academic Search

En este trabajo analizamos el nivel del gasto publico en Sanidad y Educacion de España comparandolo con otros paises europeos y de la OCDE. El analisis incluye un modelo econometrico que estima la elasticidad del gasto con respecto al PIB y al numero de estudiantes. La principal conclusion es que España tiene un nivel bajo de gasto total, publico y

Isabel Neira; Ana Iglesias

2001-01-01

197

Trabajo con Comunidades y Grupos : dominación y resistencia. Procesos que nos llevan a plantear tareas permanentes y cotidianas  

Microsoft Academic Search

Este trabajo presenta algunas ideas con respecto a las tareas permanentes y cotidianas, que se sugieren considerar en el trabajo colectivo en las comunidades y con los grupos en los que participamos. La convivencia humana, como práctica socio-cultural se convierte en una de las vivencias más complejas e importantes que son capaces de gestar lo que en el mundo actual

Teresa Cordero Cordero

2006-01-01

198

14th World Congress of IFACA FINITE-DIMENSIONAL CODER-ESTIMATOR FOR RATE-CONS... Copyright 1999 IFAC  

E-print Network

14th World Congress of IFACA FINITE-DIMENSIONAL CODER-ESTIMATOR FOR RATE-CONS... Copyright © 1999;14th World Congress of IFACA FINITE-DIMENSIONAL CODER-ESTIMATOR FOR RATE-CONS... ISBN: 0 08 043248 4Copyright 1999 IFAC #12;14th World Congress of IFACA FINITE-DIMENSIONAL CODER-ESTIMATOR FOR RATE

Nair, Girish

199

A brief guide to access the Wound Healing and Management (WHAM) Node via JBI COnNECT+  

E-print Network

A brief guide to access the Wound Healing and Management (WHAM) Node via JBI COnNECT+ To access JBI COnNECT+ and the Wound Healing and Management Node go to JBI Homepage at http and password are both the same word: - wound. #12; To go directly to the Wound Healing and Management Node

200

Probing of Brain States in Real-Time: Introducing the ConSole Environment  

PubMed Central

Recent years have seen huge advancements in the methods available and used in neuroscience employing EEG or MEG. However, the standard approach is to average a large number of trials for experimentally defined conditions in order to reduce intertrial-variability, i.e., treating it as a source of “noise.” Yet it is now more and more accepted that trial-to-trial fluctuations bear functional significance, reflecting fluctuations of “brain states” that predispose perception and action. Such effects are often revealed in a pre-stimulus period, when comparing response variability to an invariant stimulus. However such offline analyses are disadvantageous as they are correlational by drawing conclusions in a post hoc-manner and stimulus presentation is random with respect to the feature of interest. A more direct test is to trigger stimulus presentation when the relevant feature is present. The current paper introduces Constance System for Online EEG (ConSole), a software package capable of analyzing ongoing EEG/MEG in real-time and presenting auditory and visual stimuli via internal routines. Stimulation via external devices (e.g., transcranial magnetic stimulation) or third-party software (e.g., PsyScope X) is possible by sending TTL-triggers. With ConSole it is thus possible to target the stimulation at specific brain states. In contrast to many available applications, ConSole is open-source. Its modular design enhances the power of the software as it can be easily adapted to new challenges and writing new experiments is an easy task. ConSole is already pre-equipped with modules performing standard signal processing steps. The software is also independent from the EEG/MEG system, as long as a driver can be written (currently two EEG systems are supported). Besides a general introduction, we present benchmark data regarding performance and validity of the calculations used, as well as three example applications of ConSole in different settings. ConSole can be downloaded at: http://console-kn.sf.net. PMID:21716603

Hartmann, Thomas; Schulz, Hannah; Weisz, Nathan

2011-01-01

201

Air Traffic Management Technology Demonstration-1 Concept of Operations (ATD-1 ConOps)  

NASA Technical Reports Server (NTRS)

The operational goal of the ATD-1 ConOps is to enable aircraft, using their onboard FMS capabilities, to fly Optimized Profile Descents (OPDs) from cruise to the runway threshold at a high-density airport, at a high throughput rate, using primarily speed control to maintain in-trail separation and the arrival schedule. The three technologies in the ATD-1 ConOps achieve this by calculating a precise arrival schedule, using controller decision support tools to provide terminal controllers with speeds for aircraft to fly to meet times at a particular meter points, and onboard software providing flight crews with speeds for the aircraft to fly to achieve a particular spacing behind preceding aircraft.

Baxley, Brian T.; Johnson, William C.; Swenson, Harry; Robinson, John E.; Prevot, Thomas; Callantine, Todd; Scardina, John; Greene, Michael

2012-01-01

202

Decay estimates for a nonlocal p-Laplacian evolution problem with mixed boundary con-  

E-print Network

Decay estimates for a nonlocal p-Laplacian evolution problem with mixed boundary con- ditions Ra p-Laplacian evolution problem with mixed boundary conditions, that is, ut(x, t) = 0 J(x - y)|u(y, t) - u(x, t)|p-2 (u(y, t) - u(x, t)) dy for (x, t) Ã? R+ and u(x, t) = 0 in 0 Ã? R+ . The proof

Rossi, Julio D.

203

Pro/con debate: Is etomidate safe in hemodynamically unstable critically ill patients?  

PubMed Central

Etomidate is an induction agent known for its smooth intubating conditions and cardiovascular stability. Studies, however, have shown that a single dose of etomidate can result in a prolonged adrenal insufficiency. The impact of this in patients with sepsis has been a matter for debate. This review presents a pro/con case for using etomidate in hemodynamically unstable critically ill patients and provides guidance for alternative induction techniques and when the use of etomidate might be justified despite these concerns. PMID:22809235

2012-01-01

204

Video Phone 4.3 Inch LCD Display, Touch Screen , RemoCon  

E-print Network

Connector · Network Interface ­ Two(2) 10/100Mbps Fast Ethernet (RJ45) ­ One(1) RS-232C Interface (RJ45 Video In/Out Audio In/Out Fast Ethernet (LAN,WAN) RS232C Console #12;6 · Various Video Networking Number Register Recent Call Speed Dial IrDA RemoCon #12;13 Network Setup OSD (VoIP, LAN, etc) Internet

205

NASA KSC/AFRL Reusable Booster System (RBS) Concept of Operations (ConOps)  

NASA Technical Reports Server (NTRS)

This slide presentation reviews the study and findings of the study on the Concept of Operations (ConOps) for Reusable Booster System (RBS) centering on rapid turnaround and launch of a two-stage partially reusable payload delivery system (i.e., 8 hours between launches). The study was to develop rapid ground processing (aircraft like concepts) and identify areas for follow-on study, technology needs, and proof-of-concept demonstrations.

Zeno, Dnany; Mosteller, Ted; McCleskey, Carey; Jhnson, Robert; Hopkins, Jason; Miller, Thomas

2010-01-01

206

IAU Symp. 240: Binary Stars as Critical Tools & Tests in Con-temporary Astrophysics  

E-print Network

IAU Symp. 240: Binary Stars as Critical Tools & Tests in Con- temporary Astrophysics Proceedings Astronomical Union DOI: 00.0000/X000000000000000X EUVE J0825-16.3 and EUVE J1501-43.6: two dMe double telescope confirm the binary nature of the dMe stars EUVE J0825-16.3 and EUVE J1501-43.6, previously

Complutense de Madrid, Universidad

207

Foglio di esercizi N. 3 1. Con il linguaggio degli "o-piccolo": per x 0  

E-print Network

Foglio di esercizi N. 3 1. Con il linguaggio degli "o-piccolo": per x 0 2x = 1 + x log 2 + o(x), 3x = 1 + x log 3 + o(x), quindi 2x - 3x = (log 2 - log 3)x + o(x). Dato che -1 sin 1 x 1, si ha -x x sin 1 x x, e quindi (per il teorema dei due carabinieri) lim x0+ x sin 1 x = 0, ovvero x sin 1 x

Tauraso, Roberto

208

Disfrute del sol con cuidado -- Cualquier persona puede padecer cáncer de piel  

Cancer.gov

Está bien pasar algún tiempo al aire libre, pero usted debe saber que las personas de piel más oscura –incluso muchos hispanos o latinos– tienen riesgo de padecer cáncer de piel. Siempre que pueda, evite exponerse al sol, especialmente entre las 10 a.m. y las 4 p.m., cuando los rayos del sol son más fuertes. Si trabaja o juega al aire libre, cúbrase y protéjase la piel con prendas de vestir, sombreros, lentes, filtros solares.

209

Mound-ACT*DE*CON{sup SM} feasibility study. Phase 2: Final report  

SciTech Connect

A portion of the abandoned Miami-Erie Canal paralleling the Greater Miami River receives the runoff and storm-water discharge from Mound Laboratory. In 1969, a low-level plutonium leak contaminated sediment as far away as 1.5 mi from the Mound site along the old canal system. An estimated one million cubic feet of sediment requires remediation. The technology being evaluated for the remediation of the low-level plutonium-238 contamination of the sediment involves two processes: washing the sediments with ACT*DE*CON{sup SM} solution to dissolve the contaminant, followed by extraction of the solution and processing with the MAG*SEP{sup SM} process to concentrate the contaminant and allow reuse of the ACT*DE*CON{sup SM} solution. The processes are being optimized for pilot-scale and field demonstration. Phase 2 of the project primarily involved identification at the laboratory scale of the optimal ACT*DE*CON{sup SM} formulation, identification of the ion-exchanger and MAG*SEP{sup SM} particles, verification of the plutonium mobility in the treated soil, and evaluation of other process parameters according to a series of tasks.

NONE

1994-12-01

210

The Transcription Factor Con7-1 Is a Master Regulator of Morphogenesis and Virulence in Fusarium oxysporum.  

PubMed

Previous studies have demonstrated the essential role of morphogenetic regulation in Fusarium oxysporum pathogenesis, including processes such as cell-wall biogenesis, cell division, and differentiation of infection-like structures. We identified three F. oxysporum genes encoding predicted transcription factors showing significant identities to Magnaporthe oryzae Con7p, Con7-1, plus two identical copies of Con7-2. Targeted deletion of con7-1 produced nonpathogenic mutants with altered morphogenesis, including defects in cell wall structure, polar growth, hyphal branching, and conidiation. By contrast, simultaneous inactivation of both con7-2 copies caused no detectable defects in the resulting mutants. Comparative microarray-based gene expression analysis indicated that Con7-1 modulates the expression of a large number of genes involved in different biological functions, including host-pathogen interactions, morphogenesis and development, signal perception and transduction, transcriptional regulation, and primary and secondary metabolism. Taken together, our results point to Con7-1 as general regulator of morphogenesis and virulence in F. oxysporum. PMID:25271883

Ruiz-Roldán, Carmen; Pareja-Jaime, Yolanda; González-Reyes, José Antonio; G-Roncero, M Isabel

2015-01-01

211

Con_A-carbone nanotube conjugate with short wave near-infrared laser ablation for tumor therapy  

NASA Astrophysics Data System (ADS)

Using the characteristics of T cell mitogen called lectin protein from the jack-beam Canavalia ensiformis Concanavalin A (Con_A) with dual activities, cytotoxicity and immunomodulation, we have shown it has a therapeutic effect on hepatoma. Injection of Con_A can eradicate the established malign tumor, because Con_A can induce tumor cell autophagic, cell-programmed death, as well as activate the effector T cells. Combined, in this paper, with the absorption exceeding the Carbon NanoTube (CNT) band-gap (?bg=~1/CNT diameter) with an active short wave near-infrared (SWIR) (1.2~1.5 micron wavelengths), which happened to be translucent to the irradiation upon animal skin, similar to that used in hospital fingertip-clamped Pulse Oxymetry. Once the Con_ACNT is guided to hepatoma cells, it is bonded and internalized into the mitochondria (MC) compartment, the cellular energy factory. Con_A has the higher specificity for tumor cells useful for targeting because of the abnormal glycosylation on tumor cells. When CNT hitch hike with Con_A, they can t together like a laser-denotable chemical missile surgically targeting at the tumor cells precisely by Con_A-guidance. We switch on SWIR laser, when the Con_A-CNT conjugated complex has been bonded and internalized to MC of malign cells and already commenced cellular programmed death. Thus, it might appear to casual readers that we have initiated an overkill, chemical drugged autophage followed with physical laser ablation, but what if we can eradicate hepatoma totally if no blue print is left behind inadvertently in case of a partial failure. We conclude that using Con_A-CNT conjugated complex targeting specifically at malign tumor cells is a novel targeted-laser-radiation therapy for tumors in mice.

Lei, Huan-Yao; Peng, Ching-An; Tang, Ming-Jer; Reindhart, Kit; Szu, Harold H.

2009-04-01

212

Los NIH anuncian el lanzamiento de 3 estudios integrados de medicina de precisión; ALCHEMIST es para pacientes con ciertos tipos de cáncer de pulmón en estadio inicial  

Cancer.gov

Los Estudios sobre la Secuenciación e Identificación de Marcadores para el Mejoramiento de la Terapia Adjuvante para el Cáncer de Pulmón, conocidos con el nombre de ALCHEMIST, identificarán a pacientes con cáncer de pulmón en estadio inicial cuyos tumores albergan ciertos cambios genéticos, y evaluarán si los tratamientos con medicamentos que actúan sobre esos cambios pueden mejorar la supervivencia.

213

Analytical studies of groundwater-head uctuation in a coastal conned aquifer overlain by a semi-permeable layer with storage  

E-print Network

in the groundwater- head ¯uctuation in the con®ned aquifer. While leakage is generally more important than storage greater than the storage coecient of the con®ned aquifer. This assumption may not be valid whenAnalytical studies of groundwater-head ¯uctuation in a coastal con®ned aquifer overlain by a semi

Jiao, Jiu Jimmy

214

The rights, tensions, and ideas that inform the con-temporary human experience were explored by the  

E-print Network

The rights, tensions, and ideas that inform the con- temporary human experience were explored Trustee. Examining the Human Experience ANDREAKANE CLIFFMOORE #12;; and the conception and challenges of human rights from historical, philo- sophical, political, and sociological

215

32 Wesley C. Salmon -it has been appropriate to deny that such appeals to functions involve the con-  

E-print Network

32 Wesley C. Salmon -it has been appropriate to deny that such appeals to functions involve the con's (1962) defense of deductive explanation in her contribution to the third volume #12;34 Wesley C. Salmon

Fitelson, Branden

216

The Credibility Revolution in Empirical Economics: How Better Research Design is Taking the Con out of Econometrics  

E-print Network

Just over a quarter century ago, Edward Leamer (1983) reflected on the state of empirical work in economics. He urged empirical researchers to “take the con out of econometrics” and memorably observed (p. 37): “Hardly ...

Angrist, Joshua

2010-01-01

217

Extenso estudio realizado en muchos centros demuestra que hay una precisión comparable de la colonoscopia virtual con la colonoscopia convencional  

Cancer.gov

Según los resultados del Estudio Nacional de Colografía de Tomografía Computarizada de la American College of Radiology Imaging Network, ACRIN, la colografía de tomografía computarizada, también conocida como colonoscopia virtual, es comparable a la colonoscopia convencional en su capacidad para detectar con precisión cáncer y pólipos precancerosos y podría servir como examen selectivo inicial de detección de cáncer colorrectal. La colonoscopia convencional usa un tubo largo, flexible, con cámara, para ver el revestimiento del colon.

218

Víctimas y victimarios: Cómplices del discurso del poder en Una noche con el Sr. Magnus e hijos de Ricardo Monti  

E-print Network

FALL 1989 37 Víctimas y victimarios: Cómplices del discurso del poder en Una noche con el Sr. Magnus e hijos de Ricardo Monti Roberto Previdi Froelich ... porque nunca podemos odiar a las personas que sabemos son capaces de hacer exactamente... en los lados ocultos que encarnan la sutil naturaleza de la ideología burguesa en su discurso del poder. Si bien presenciamos una evidente ruptura con una construcción tradicional del realismo teatral,1 el teatro de Monti, a través de sus...

Previdi Froelich, Roberto

1989-10-01

219

Esercizi quarta settimana1 Determinare lo sviluppo asintotico delle seguenti funzioni nella scala delle potenze per x 0 con  

E-print Network

delle potenze per x 0 con almeno tre termini consecutivi: ex - sin x - 1 sinh2 x (1 - cosh x) sin x 3 x + x4 cos sin x sin(1 - cos x) esin x cos x + sin x ex2 Determinare lo sviluppo asintotico delle seguenti funzioni nella scala delle potenze per x + con almeno tre termini consecutivi: 3 x + x4 sinh sin

Marconi, Umberto

220

Presentación del estudio “Links” de hombres que tienes sexo con hombres en Buenos Aires, Argentina  

PubMed Central

Resumen Estudios previos en Buenos Aires reportaron altas prevalencias de HIV entre HSH, con valores que oscilan entre 9 y 14% durante casi 10 años de continuo testeo. El objetivo principal de este estudio fue la evaluación de factores relacionados al comportamiento de alto riesgo para transmisión del HIV entre HSH entre los que se incluyen el conocimiento y factores emocionales, socioculturales y ambientales. Por otro lado se realizó la estimación de prevalencia e incidencia de HIV utilizando RDS (Respondent Driven Sampling), así como la presencia de otras infecciones de transmisión sexual. Por último se evaluaron los hábitos de testeo para HIV indagando que factores facilitan o impiden su realización. El estudio constó de dos fases, en primer lugar una fase cualitativa y posteriormente una fase cuantitativa con una duración total de 4 años y medio. Durante la fase cualitativa se realizaron 44 entrevistas individuales en profundidad, 8 grupos focales y 10 observaciones etnográficas (hoteles, baños públicos (“teteras”), cines pornográficos, fiestas privadas, dark rooms y discotecas). Durante la fase cuantitativa del estudio se realizó el reclutamiento de 500 participantes que provinieron de la Ciudad Autónoma de Buenos Aires, así como del Gran Buenos Aires. El reclutamiento se comenzó con 16 participantes llamados semillas. Se realizó el diagnóstico de infección por HIV, hepatitis B y C (HBV y HCV), Treponema pallidum, Virus Papiloma Humano (HPV) y Chlamidias. La colaboración establecida entre los grupos de trabajo enfocados en áreas diversas posibilitó el abordaje conjunto de nuevas estrategias de investigación antes no exploradas en nuestro país. Los resultados más relevantes de esta investigación serán progresivamente publicados en sucesivos números de Actualizaciones en SIDA. PMID:25264397

Carballo-Diéguez, Alex; Ávila, María M; Balán, Iván C.; Marone, Rubén; Pando, María A.; Barreda, Victoria

2011-01-01

221

Perceived pros and cons of smoking and quitting in hard-core smokers: a focus group study  

PubMed Central

Background In the last decade, so-called hard-core smokers have received increasing interest in research literature. For smokers in general, the study of perceived costs and benefits (or ‘pros and cons’) of smoking and quitting is of particular importance in predicting motivation to quit and actual quitting attempts. Therefore, this study aims to gain insight into the perceived pros and cons of smoking and quitting in hard-core smokers. Methods We conducted 11 focus group interviews among current hard-core smokers (n = 32) and former hard-core smokers (n = 31) in the Netherlands. Subsequently, each participant listed his or her main pros and cons in a questionnaire. We used a structural procedure to analyse the data obtained from the group interviews and from the questionnaires. Results Using the qualitative data of both the questionnaires and the transcripts, the perceived pros and cons of smoking and smoking cessation were grouped into 6 main categories: Finance, Health, Intrapersonal Processes, Social Environment, Physical Environment and Food and Weight. Conclusions Although the perceived pros and cons of smoking in hard-core smokers largely mirror the perceived pros and cons of quitting, there are some major differences with respect to weight, social integration, health of children and stress reduction, that should be taken into account in clinical settings and when developing interventions. Based on these findings we propose the ‘Distorted Mirror Hypothesis’. PMID:24548463

2014-01-01

222

Effect of Diuretics on Salivary Flow, Composition and Oral Health Status: A Clinico-biochemical Study  

PubMed Central

Background: Saliva represents an increasingly useful tool of diagnosis. Several factors such as salivary flow rates (SFRs) (unstimulated and stimulated) (U and S), pH, buffering capacity and consistency can be altered due to several disease processes or medications prescribed for various diseases. Alterations of SFRs, pH, buffering capacity and various ion concentrations can influence the pathogenesis of some of the oral diseases. Aim: Evaluation of the effect of diuretics on oral health status with regard to SFRs (U and S), pH, buffering capacity, total protein content, various ion concentrations and oral mucosal lesions. Subjects and Methods: A total of 100 patients were categorized into test group and control group based on usage of diuretics. Unstimulated and stimulated saliva were collected and evaluated for flow rates. Salivary pH was measured using pH meter. Buffering capacity was measured using Aranha's technique. Salivary Na+, K+ and Cl? concentrations were measured using electrolyte analyzer CORNLEY ACCULYTE-3P in ion-selective electrode method. Salivary total protein content was measured by spectrophotometric method. Dental Caries and periodontal status were measured by using decayed, missing, filled teeth index and Russell's periodontal index respectively. Oral mucosal examination was carried out to identify the mucosal lesions. Results: The obtained results were subjected to statistical analysis using Statistical package for social sciences software (SPSS), version 16, IBM Company by Chi-square test and unpaired t-test. Highly significant P for alterations of SFR/U (P < 0.001), SFR/S (P < 0.001), pH (P < 0.001), Na+ concentration (P < 0.001), buffering capacity (P < 0.001) and moderate significance for Cl? concentration (P < 0.01) were found. Alterations of total protein (P = 0.14) and K+ (P = 0.65) concentrations were not statistically significant. High prevalence was found for caries (P < 0.01), periodontal status (P < 0.001) and mucosal lesions (P < 0.01). Conclusion: Our study shows that diuretic medication significantly reduces SFRs (xerostomia) and alters salivary composition which may have an impact on the incidence of dental caries, periodontal diseases and mucosal lesion formation. PMID:25221702

Prasanthi, B; Kannan, N; Patil, RR

2014-01-01

223

Hereditary spastic paraplegia: clinico-pathologic features and emerging molecular mechanisms  

PubMed Central

Hereditary spastic paraplegia (HSP) is a syndrome designation describing inherited disorders in which lower extremity weakness and spasticity are the predominant symptoms. There are more than 50 genetic types of HSP. HSP affects individuals diverse ethnic groups with prevalence estimates ranging from 1.2 to 9.6 per 100,000 [39, 70, 77, 154, 185]. Symptoms may begin at any age. Gait impairment that begins after childhood usually worsens very slowly over many years. Gait impairment that begins in infancy and early childhood may not worsen significantly. Post mortem studies consistently identify degeneration of corticospinal tract axons (maximal in the thoracic spinal cord) and degeneration of fasciculus gracilis fibers (maximal in the cervico-medullary region). HSP syndromes thus appear to involve motor-sensory axon degeneration affecting predominantly (but not exclusively) the distal ends of long central nervous system (CNS) axons. In general, proteins encoded by HSP genes have diverse functions including axon transport (e.g. SPG30/KIF1A, SPG10/KIF5A and possibly SPG4/Spastin); endoplasmic reticulum morphology (e.g. SPG3A/Atlastin, SPG4/Spastin, SPG12/reticulon 2, and SPG31/REEP1, all of which interact); mitochondrial function (e.g. SPG13/chaperonin 60/heat shock protein 60, SPG7/paraplegin; and mitochondrial ATP6; 4) myelin formation (e.g. SPG2/Proteolipid protein and SPG42/Connexin 47); 5) protein folding and ER-stress response (SPG6/NIPA1, SPG8/K1AA0196 (Strumpellin), SGP17/BSCL2 (Seipin) [113-115], “mutilating sensory neuropathy with spastic paraplegia” due to CcT5 mutation and presumably SPG18/ERLIN2); 6) corticospinal tract and other neurodevelopment (e.g. SPG1/L1 cell adhesion molecule and SPG22/thyroid transporter MCT8); 7) fatty acid and phospholipid metabolism (e.g. SPG28/DDHD1, SPG35/FA2H, SPG39/NTE, SPG54/DDHD2, and SPG56/CYP2U1); and 8) endosome membrane trafficking and vesicle formation (e.g. SPG47/AP4B1, SPG48/KIAA0415, SPG50/AP4M1, SPG51/AP4E, SPG52/AP4S1, and VSPG53/VPS37A). The availability of animal models (including bovine, murine, zebrafish, Drosophila, and C. elegans) for many types of HSP permits exploration of disease mechanisms and potential treatments. This review highlights emerging concepts of this large group of clinically similar disorders. For recent review of HSP including historical descriptions, differential diagnosis, and additional references see [78]. PMID:23897027

Fink, John K.

2014-01-01

224

Correlation between CT Perfusion and Clinico-Pathological Features in Prostate Cancer: A Prospective Study.  

PubMed

Background The aim of the study was to assess the correlation between computed tomography perfusion (PCT) parameters and PSA levels, Gleason score, and pTNM stage in patients with prostate cancer (PCa). Material and Methods One hundred twenty-five patients with localized PCa were prospectively enrolled in the study. All patients were diagnosed due to suspicious prostate findings and elevated PSA serum levels and underwent PCT followed by core biopsy and radical prostatectomy. Blood flow (BF), blood volume (BV), mean transit time (MTT), and permeability-surface (PS) area product were computed in the suspected PCa area and normal prostatic tissue. Core biopsy followed by prostatectomy was performed 2-4 weeks after PCT. Correlation between PCT findings and PSA levels, Gleason score, and pTNM stage were analyzed. Results The mean age of patients was 64 years. All patients had elevated PSA levels (mean value 6.2 ng/ml). Nineteen patients (15.9%) were at low risk of recurrence, 91 (76.5%) were at moderate risk, and 9 (7.6%) were at high risk according to National Comprehensive Cancer Network criteria. PCa was visible on PCT as focal peripheral CT enhancement in 119 out of 125 patients (sensitivity 95.2%). Significant correlations between BV, BF, and PS values and PSA level were found (p<0.05), as well as a trend for difference between BV, BF, and PS in poorly and moderately differentiated tumors (according to Gleason score) in comparison with highly differentiated PCa (p<0.08). The analysis also revealed a correlation between mean perfusion values and BV, MTT, PS, and pTNM cancer stage (p<0.04). Conclusions Our study suggests that in low- and intermediate- risk patients, PCT parameters correlate with PSA values, Gleason score, and pTNM stage and can be useful for initial tumor staging. PMID:25582437

?uczy?ska, El?bieta; Heinze-Paluchowska, Sylwia; Blecharz, Pawe?; Jereczek-Fossa, Barbara; Petralia, Giuseppe; Bellomi, Massimo; Stelmach, Andrzej

2015-01-01

225

Clinico-pathological Study of Space Occupying Lesions of Nasal Cavity, Paranasal Sinuses and Nasopharynx  

PubMed Central

Background: A variety of non-neoplastic and neoplastic lesions of nasal cavity, paranasal sinuses and nasopharynx are commonly encountered in clinical practice. The aim of this study was to study clinical and histopathological profile of space occupying lesions of nasal cavity, paranasal sinuses and nasopharynx in a tertiary care hospital of Rajasthan over the period of January 2013 to January 2014. Materials and Methods: This was a prospective study of 147 cases (male 100, female 47; age group ranging from less than 1 y to 76 y) of space occupying lesions of nasal cavity, paranasal sinuses and nasopharynx over the period of 12 months (from January 2013 to January 2014). All tissues after fixation in 10% buffered formalin, processed and then stained with Hematoxylin & Eosin to study various histopathological patterns. Results: These 147 cases were broadly categorized in two categories, one category as nasal and paranasal sinus masses and the other as nasopharyngeal masses with 91 and 56 cases, respectively. These lesions were common in second and third decades of life with male predominance. Among nasal and paranasal sinus masses, there were 67 (73.6%) non-neoplastic and 24 (26.4%) neoplastic lesions. Inflammatory polyps (89.5%) were the most common among the non-neoplastic masses; Inverted papilloma (45.46%) the most common among the benign neoplastic and squamous cell carcinoma (46.15%) was the commonest out of all malignant masses. Out of 56 nasopharyngeal masses, there were 53 (94.6%) non neoplastic and 3 (5.4%) neoplastic lesions. Majority of these i.e. 52 cases were of adenotonsillar hypertrophy. Conclusion: We concluded that complete clinical, radiological and histopathological correlation helps us to categorize these sinonasal lesions into various non-neoplastic and neoplastic types. But final histopathological examination provides a confirmatory diagnosis, although Immunohistochemistry is the final diagnostic method in few cases.

Mathur, Kusum

2014-01-01

226

[Prognosis in patients with myelodysplastic syndromes based on cytomorphologic and clinico-biologic parameters].  

PubMed

Under myelodysplastic syndromes we presume a heterogeneous group of malignant hemopathies with clearly described characteristics of the disease given by a cooperative group of French, American and British authors. Myelodysplastic syndromes most frequently occur at older age. Survival of these patients, after the diagnosis is made, is mostly short because the disease evolves into acute leukemia. Myelodysplastic syndrome is characterized by appearance of refractive anemia, leukemia, thrombocytopenia with signs of expressed dishematopoiesis of the bone marrow. Clear criteria which could define forms with fast or slow course leading to acute leukemia don't exist, so there is a need to group patients into those with good or with bad outcome. The investigation included following parameters important for the outlook of the disease: 1. enlargement of lymph nodes, liver and spleen, 2. biochemical examination of peripheral blood, 3. cytomorphologic changes in the peripheral blood cells and bone marrow. By a follow-up of described parameters a statistically significant influence on survival of the sick concerning the degree of present anemia, absolute number of granulocytes, number of thrombocytes, dishematopoiesis of the peripheral blood and bone marrow, lymphadenomegaly, hepatomegaly and splenomegaly was not found. The percentage of blast in the peripheral blood and bone marrow has a statistically significant influence on patients' short survival. PMID:7791674

Beli?, A; Stefanovi?, N; Pejin, D; Mihajlovi?, M; Popovi?, S; Kljaji?, D; Uzurov, V; Spasojevi?, J

1994-01-01

227

Hereditary spastic paraplegia: clinico-pathologic features and emerging molecular mechanisms.  

PubMed

Hereditary spastic paraplegia (HSP) is a syndrome designation describing inherited disorders in which lower extremity weakness and spasticity are the predominant symptoms. There are more than 50 genetic types of HSP. HSP affects individuals of diverse ethnic groups with prevalence estimates ranging from 1.2 to 9.6 per 100,000. Symptoms may begin at any age. Gait impairment that begins after childhood usually worsens very slowly over many years. Gait impairment that begins in infancy and early childhood may not worsen significantly. Postmortem studies consistently identify degeneration of corticospinal tract axons (maximal in the thoracic spinal cord) and degeneration of fasciculus gracilis fibers (maximal in the cervico-medullary region). HSP syndromes thus appear to involve motor-sensory axon degeneration affecting predominantly (but not exclusively) the distal ends of long central nervous system (CNS) axons. In general, proteins encoded by HSP genes have diverse functions including (1) axon transport (e.g. SPG30/KIF1A, SPG10/KIF5A and possibly SPG4/Spastin); (2) endoplasmic reticulum morphology (e.g. SPG3A/Atlastin, SPG4/Spastin, SPG12/reticulon 2, and SPG31/REEP1, all of which interact); (3) mitochondrial function (e.g. SPG13/chaperonin 60/heat-shock protein 60, SPG7/paraplegin; and mitochondrial ATP6); (4) myelin formation (e.g. SPG2/Proteolipid protein and SPG42/Connexin 47); (5) protein folding and ER-stress response (SPG6/NIPA1, SPG8/K1AA0196 (Strumpellin), SGP17/BSCL2 (Seipin), "mutilating sensory neuropathy with spastic paraplegia" owing to CcT5 mutation and presumably SPG18/ERLIN2); (6) corticospinal tract and other neurodevelopment (e.g. SPG1/L1 cell adhesion molecule and SPG22/thyroid transporter MCT8); (7) fatty acid and phospholipid metabolism (e.g. SPG28/DDHD1, SPG35/FA2H, SPG39/NTE, SPG54/DDHD2, and SPG56/CYP2U1); and (8) endosome membrane trafficking and vesicle formation (e.g. SPG47/AP4B1, SPG48/KIAA0415, SPG50/AP4M1, SPG51/AP4E, SPG52/AP4S1, and VSPG53/VPS37A). The availability of animal models (including bovine, murine, zebrafish, Drosophila, and C. elegans) for many types of HSP permits exploration of disease mechanisms and potential treatments. This review highlights emerging concepts of this large group of clinically similar disorders. PMID:23897027

Fink, John K

2013-09-01

228

GENETIC DETERMINANTS AND CLINICO-PATHOLOGICAL OUTCOMES OF HELICOBACTER PYLORI INFECTION  

PubMed Central

Helicobacter pylori is a spiral Gram-negative bacterium with a relatively small genome and is known to be the most common human bacterial infection worldwide, infecting about half of the world's population. The bacterium represents one of the most successful human pathogens, inducing severe clinical symptoms only in a small subset of individuals, thus signifying a highly balanced degree of co-evolution of H. pylori and humans. The prevalence of Helicobacter pylori infection varies greatly among countries and among population groups within the same country, but is falling in most developed countries. The clinical course of H. pylori infection is highly variable and is influenced by both microbial and host factors including genetic susceptibility while the pattern and distribution of inflammation correlate strongly with the risk of clinical sequelae, namely duodenal or gastric ulcers, mucosal atrophy, gastric carcinoma, or gastric lymphoma. Cytokine gene polymorphisms directly influence inter-individual variation in the magnitude of cytokine response, and this clearly contributes to an individual's ultimate clinical outcome. Polymorphisms in genes coding for innate immune factors have also been incriminated in the pathogenesis of H. pylori related disease, while promoter hypermethylation of tumor suppressor genes is considered an important factor in carcinogenesis and known to be present in H. pylori associated gastric tumors. Functional genomics may fill many of the gaps in our understanding of the pathogenesis of H. pylori infection and accelerate the development of novel therapies, including H. pylori specific antimicrobial agents. PMID:25332697

Oluwasola, A.O.

2014-01-01

229

Clinico-pathological investigations of Rasmussen encephalitis suggest multifocal disease progression and associated focal cortical dysplasia.  

PubMed

Rasmussen encephalitis is a devastating neurological disorder characterised by seizures, brain inflammation, and progressive hemispheric atrophy. The objective of the current study was to systematically characterise patterns of structural lesions in children with Rasmussen encephalitis, referred for modified anatomical hemispherectomy at the Tsinghua University Epilepsy Center in Beijing. Seven consecutive patients were investigated with a mean age at operation of 4.5 years, who suffered from medically intractable seizures for a mean of 1.6 years. Foci of abnormally increased T2 signal intensity were observed in all patients. With the exception of one child, all patients presented with progressive unilateral cerebral atrophy. FDG-PET imaging revealed extensive regions of hypometabolism within the affected cerebral hemisphere in 3 of 4 patients. Diagnosis of Rasmussen encephalitis was confirmed histologically, demonstrating CD68 positive microglial nodules, as well as CD3 and CD8 positive T lymphocytes invading the cerebral parenchyma. An intriguing observation was the heterogenous distribution of patterns of lesions throughout the affected hemisphere, suggesting multifocal manifestation and distinct sequences of disease progression, from discrete foci of inflammatory infiltrates (stage 1) to extensive cortical destruction (stage 4). Atypical hippocampal sclerosis (HS), with neuronal cell loss affecting most prominently the CA4 region (HS type 3 or end folium sclerosis), was evident in 5 of 7 cases. Four hippocampi also showed chronic inflammation. In addition, we observed associated focal cortical dysplasia (FCD; ILAE type IIId) in 4 of 7 children, supporting the concept of acquired and postmigratory FCD pathomechanisms. Postsurgical seizure freedom was achieved in all children with a mean follow-up period of 2.7 years and continuous antiepileptic medication. PMID:23531608

Wang, Dandan; Blümcke, Ingmar; Gui, Qiuping; Zhou, Wenjing; Zuo, Huancong; Lin, Jiuluan; Luo, Yang

2013-03-01

230

[Diagnosis and course of Creutzfeldt-Jakob disease (clinico-pathologoanatomic parallels].  

PubMed

Long-term observations of five patients aged 40 to 70 years made it possible to diagnose Creutzfeld-Jacob's disease (CJD) in their life time. In three cases, the diagnosis of CJD was confirmed at autopsy; one patient died at home. The works of I. Kreutzfeld and A. Jacob and the authors' observations confirm that the disease lasts 4-5 years or more. Marked manifestations of the disease were observed for two years. Some differential diagnostic criteria are presented permitting the differentiation of CJD from other atrophic processes described by Alzheimer, Pick and others. PMID:6395598

Orlova, E G; Salimova, L V

1984-01-01

231

The significance of cortical pathology in progressive supranuclear palsy: Clinico-pathological data in 10 cases  

Microsoft Academic Search

Summary Several observations suggest that the cortical lesions of progressive supranuclear palsy (PSP) play a role in the clinical symptoms and signs of the disease, although direct evidence for this is lacking. We addressed the significance of these lesions in a series of 10 cases of definite PSP. Tau positive cortical lesions were constant, and the mean density of neurofibriUary

M. Verny; C. Duyckaerts; Y. Agid; J.-J. Hauw

1996-01-01

232

[The clinico-epidemiological premises for antioxidant prevention and treatment in chronic myocardial infarct].  

PubMed

The improvement of therapeutic and recoverable proceeding to chronic myocardial infarction (IMC) imposes a complex epidemiological estimation of the global cardiovascular risk, of their clinical and biological status. The retrospective evaluation of the risk factors (RF) by epidemiological methods, in 38 hospitalized prevalence of both constitutional and behavioral factors, and the quantification of the risk state, according to graph Euro 194, has pointed on the fact that 50% of IMC cases have presented a global risk of 10-20%. That justified the application of a preventive conduct in order to continually neutralize the associates FR. The biochemical determinations have allowed to frame the dyslipidemic patients, according to the ARCOL classification in the classes D (29.2%), E (25.0%) and B (20.8%) with direct implication in the adopted therapy. The colorimetric dozing with thyo-barbituric acid of the malonly dialdehyde (MAD) each is a product of the lipidic peroxidation, as well as the interpreting or correlation of the registered values with an evolutive clinic stage, and with the existence of some existing diseases (diabetes, chronic hepatitis etc.) along with signification of other dismethabolical parameters (cholesterol, triglycerides, LDLc, apoB) have confirmed the necessity of a complex therapy, including an antioxidative treatment, having the role to directly inhibit or exclude the free radicals resulted after the oxidative stress of the infarct. PMID:9455439

Azoic?i, D; Mitu, F; Iacobovici, A; Pavel, M; Jerca, L; Ungureanu, D; Popovici, I; Cojocaru, M; Ivan, A; Gheorghi??, N

1996-01-01

233

Clinico-immunologic aspects of botulinum toxin type B treatment of cervical dystonia.  

PubMed

In this multicenter study of 100 patients with cervical dystonia, we examined the immunogenicity of botulinum toxin type B (BTX-B) and correlated the clinical response with the presence of blocking antibodies (Abs) using a novel mouse protection assay. One-third of the patients who were negative for BTX-B Abs at baseline became positive for BTX-B Abs at last visit. Thus, the high antigenicity of BTX-B limits its long-term efficacy. PMID:17190952

Jankovic, J; Hunter, C; Dolimbek, B Z; Dolimbek, G S; Adler, C H; Brashear, A; Comella, C L; Gordon, M; Riley, D E; Sethi, K; Singer, C; Stacy, M; Tarsy, D; Atassi, M Z

2006-12-26

234

Clinico-pathological correlates of incidentally revealed thyroid swelling in Bihar, India  

PubMed Central

Background: Global prevalence of thyroid cancer has been on the rise in recent decades. Objectives: To study the clinical presentations to reach an agreement for diagnosis and optimal management of incidentally revealed thyroid swellings for early diagnosis. Materials and Methods: A prospective study was carried out on 178 cases of incidentally detected thyroid swelling attending a tertiary care teaching institute of Kishanganj Bihar. All the cases were subjected to a thorough clinical examination followed by evidence-based interventions. Fine needle aspiration cytology was done in all the cases preoperatively as out-patients basis and histopathologically confirmed postoperatively. Results: The highest incidence of thyroid swelling (75.84%) was found in the age group of 20-40 years; a female preponderance was noted in the ratio 4:1. The duration of swelling ranged from six months to three years. Difficulty in swallowing and breathing was complained by 23 (12.9%) and 18 (10.1%) of the patients respectively. Typically the swellings were located in the right lobe. Commonly the subjects in our study were in euthyroid state (90%) and were with firm swellings (66.7%). Follicular and anaplastic carcinoma was important postoperative cytological findings. Majority of surgical intervention was hemithyroidectomy (55.06%). Conclusion: Incidentally revealed thyroid swelling was quite high in eastern India for which we need a consensus line of intervention. PMID:22368398

Sengupta, Arup; Pal, Ranabir; Kar, Sumit; Zaman, Forhad Akhtar; Basu, Mausumi; Pal, Shrayan

2012-01-01

235

Étude clinico-radiologique des déformations du crâne dans les plagiocéphalies sans synostose  

Microsoft Academic Search

The aim of this study was to analyze the mechanism of the skull deformation observed in frontal and occipital plagiocephaly without synostosis.Population and methods. – From 1987 to 2001, 96 plagiocephalies without synostosis, 72 males and 24 females, were examined. There were 72 Frontal Plagiocephalies (FP) and 24 Occipital Plagiocephalies (OP). The clinical examination of the neck muscles was performed

G Captier; N Leboucq; M Bigorre; F Canovas; F Bonnel; A Bonnafé; P Montoya

2003-01-01

236

Ageing and degeneration in the macular region: a clinico-pathological study.  

PubMed Central

Clinical and pathological examination was performed on 378 eyes from 216 patients aged 43 to 97 years. This series represented eyes in which the fundi were normal or showed various manifestations of senile macular degeneration. The eyes were divided into six groups according to the histological appearance of a linear deposit at the base of the retinal pigment cells. Groups I and II were considered to represent normal ageing, Groups III and IV the progressive development of senile macular degeneration and Groups V and VI the end-results. Group I showed no basal linear deposit. Thickening and hyalinization of Bruch's membrane was noted as early as the fifth decade. Group II showed patchy development of the basal linear deposit in relation to thickened or basophilic segments of Bruch's membrane, or over intercapillary hyalinization extending to the level of the outer surface of the choriocapillaris. Almost all eyes in these two groups retained a normal fundus appearance but visual acuity declined with age even in the absence of other causes. In Group III the basal deposit formed a thin continuous layer associated with moderate degeneration of the retinal pigment epithelium. More than half the eyes had developed a clinical disturbance of pigmentation and in most vision was reduced. Group IV was characterized by thickening of the deposit and more pronounced disturbance of the pigment epithelium. Clinically most eyes showed coarse pigmentary changes and vision was in the order of 6/24. 14-3 per cent of eyes in this group showed early neovascularization from the choroid. In Group V the pigment epithelium disappeared to produce circumscribed areas of depigmentation. The basal linear deposit could be traced throughout the depigmented area in most eyes. Thin fibrovascular sheets were found beneath the pigment epithelium in 41-7 per cent of eyes. Group VI represented disciform degeneration. The basal linear deposit could often be demonstrated as a disrupted hyalinized layer incorporated into the scar. Disciform degeneration was an alternative end-result to geographical atrophy. In each group the clinical and histological findings may be modified by the presence of drusen or by atrophy of the choroid. The basal linear deposit consisted of banded fibres embedded in granular material lying between the plasma infoldings and the basement membrane of the retinal pigment epithelium. This deposit seems to be a manifestation of gradual failure of the pigment epithelium and proved to be the most suitable criterion by which to study the natural history of senile macular degeneration. Images PMID:952802

Sarks, S H

1976-01-01

237

[Possibilities of clinico-cytological diagnosis in contagious equine metritis (CEM)].  

PubMed

Clinical, bacteriological and serological examinations on a 6 years old pony mare were performed. Cytological alterations in the genital tract were also recorded. A cellular reaction was seen after infection with T. equigenitalis. This reaction is an evidence for infection but it is not specific for this organism. Cytological studies should be performed on mares especially in cases of latent infections to complete bacteriological examination and to prevent false positive or negative results. PMID:1872793

Ullrich, E; Selbitz, H J; Schieck, R; Friedrich, U; Schulz, J

1991-05-01

238

Demographic and Clinico-Epidemiological Features of Dengue Fever in Faisalabad, Pakistan  

PubMed Central

This cross-sectional study was carried out to explore the epidemiological and clinical features of dengue fever in Faisalabad, Pakistan during 2011 and 2012. During the study period, anti-dengue IgM positive cases were reported in the post-monsoon period during the months of August–December. Certain hotspots for the dengue infection were identified in the city that coincide with the clusters of densely populated urban regions of the city. Out of total 299 IgM positive patients (male 218 and female 81); there were 239 dengue fever (DF) and 60 dengue hemorrhagic fever (DHF) patients. There was decrease in the median age of dengue patients from 31 years in 2011 to 21.5 years in 2012 (p<0.001). Abdominal pain was seen in 35% DHF patients followed by nausea in 28.3%, epistaxis in 25% and rash in 20% patients (p<0.05). Patients reported to be suffering from high-grade fever for an average of 8.83 days in DHF as compared to 5.82 days in DF before being hospitalized. Co-morbidities were found to be risk factor for the development of DHF in dengue patients. Clinical and laboratory features of dengue cases studied could be used for the early identification of patients at risk of severe dengue fever. PMID:24595236

Raza, Faiz Ahmed; Rehman, Shafiq ur; Khalid, Ruqyya; Ahmad, Jameel; Ashraf, Sajjad; Iqbal, Mazhar; Hasnain, Shahida

2014-01-01

239

[Clinico-functional correlations in chronic obstructive bronchopneumopathy: dyspnea and arterial oxygenation].  

PubMed

The severity of dyspnoea was confronted to the value of the partial pressure of arterial oxygen at rest in a group of 51 patients with chronic non-specific pneumopathy associated to medium or severe ventilatory obstruction (VEMS under 1,5 I). The patients have been classified as "predominantly bronchitic" or "predominantly emphysematous" on the basis of clinical, radiological and biological criteria. In the group as a whole there was no relation between the partial pressure of arterial oxygen and the severity of the dyspnoea. The analysis of sub-groups evidenced a tendency to decrease of the oxygen pressure with accentuation of dyspnoea in the "bronchitis" group, although the coefficient value of this inverse correlation did not reach the treshold of statistical significance (r = -0,46; p greater than 0,05). PMID:188100

Manicatide, M; Racoveanu, C; Teculescu, D

1976-01-01

240

Diagnosis and Clinico-Radiological Presentation in an Aggressive Maxillary Brown Tumour  

PubMed Central

Brown’s tumour is an uncommon focal giant cell lesion which arises as a result of the effect of increased parathyroid hormone on bone tissues in hyperparathyroidism. The mandible is the predominantly affected site in the maxillofacial area and a maxillary involvement is rare. The severity of the lesion, caused by a Brown’s tumour, may lead to evident osteolysis and gross deformity in the maxillofacial region, which suggests the need for making an early diagnosis and giving prompt treatment. We are reporting a male patient who presented with a massive painful swelling in the right maxilla as the first manifestation of primary hyperparathyroidism, caused by a parathyroid adenoma. PMID:24995255

Mubeen; KR, Vijayalakshmi; Singh, Chandravir

2014-01-01

241

[The clinico-epidemiological characteristics of HIV infection in 93 adults in the Republic of Moldova].  

PubMed

We have examined 93 adults HIV serum-positive (citizens of Moldova Republic), admitted in 1994-1998 (months I-VIII) to the Hospital of Infections Diseases 'T. Ciorba'--Kishinev. Since 1996 the number of HIV infected people began to grow up rapidly. Most affected group was those of 16-29 years old people--78.4%. The major way of the HIV transmission was the use of intravenous drugs (81.7%). Number of men i.v. drug users was two time greater then women's (88.9%/66.7%). At the time of HIV infection diagnosis 77.9% of patients were in the clinical category A, 16.9% in B and 5.2% in C (1993 classification system, CDC-Atlanta). During the control period seven persons were redistributed from the clinical category A to B and two from A to C. A high prevalence value for tuberculosis in AIDS (71.4%) has been observed, this infection being the first manifestation of stadium C in 57.1% of cases. The circulation of hepatitis viruses is high in the drug users community: the markers of VHC were detected in 84.2%, HBsAg in 17.1% and VHD antibodies in 9.2%. PMID:10422323

Cojocaru, S; Cojocaru, R

1998-01-01

242

Clinico-biochemical studies on acute toxic nephropathy in goats due to uranyl nitrate  

SciTech Connect

Acute toxic nephropathy was produced in 6 healthy goats by injecting intravenously 1% uranyl nitrate (UN) (15 mg/kg body weight). The early painful clinical signs simulating shock progressed with subnormal temperature, slow-shallow respiration and arrhythmic pulse followed by death due to respiratory failure within 96 to 120 hr. All the affected goats had normocytic normochromic anemia, leucocytosis, neutrophilia with left shift eosinopenia, decreased monocytes and presence of 1-2% reticulocytes in the peripheral blood smears. On blood chemical analysis, a uniform and continuous rise was seen in serum creatinine with a concomitant daily increase of serum urea and uric acid. Simultaneous analysis of urine indicated polyuria leading to oliguria, acidic pH, albuminuria, glycosuria with presence of neutrophils, RBC's, epithelial and fatty casts, increase of triple phosphate, and cystine crystals reflecting acute damage of kidneys in the affected goats.

Dash, P.K.; Joshi, H.C.

1989-02-01

243

A clinico-epidemiological study of cognitive function status of community-dwelling elderly  

PubMed Central

Background: Cognitive decline and dementia are an important problem affecting quality-of-life in elderly and their caregivers. There is regional variation in prevalence of cognitive decline as well as risk factors from region to region. Aim: The aim was to determine the prevalence of dementia and cognitive decline and its various risk factors in the elderly population of more than 60 years in Eastern Uttar Pradesh (India). Materials and Methods: A camp-based study was conducted on rural population of Chiraigaon block of Varanasi district from February 2007 to May 2007. Block has 80 villages, of which 11 villages were randomly selected. Eleven camps were organized for elderly people in 11 randomly selected villages on predetermined dates. A total of 728 elderly persons of age >60 years were examined, interviewed and data thus collected was analyzed. Elderly who got Hindi-mini-mental state examination (HMSE) score developed by Ganguli based on the Indo-US Cross-National Dementia Epidemiology Study) score ?23 were evaluated further and in those with confirmed cognitive and functional impairment, diagnosis of dementia was assigned according to Diagnostic and Statistical Manual for Mental Disorder fourth edition criteria after ruling out any psychiatric illness or delirium. Based on International Classification of Diseases-10 diagnostic criteria sub-categorization of dementia was done. Results: Mean, median and 10th percentile of HMSE of the study population were 23.4, 24 and 17, respectively. About 14.6% elderly had scored <17. 42.9% of rural elderly population had HMSE score <23, 70.6% <27 and 27.7% between 23 and 27. Literate people had statistically significant higher mean HMSE score (26.1 ± 3.9) than illiterate people (22.9 ± 4.9). Other risk factors were female gender, malnutrition, and obesity. Prevalence of dementia was 2.74%; in male 2.70% and in female 2.80%. Most common type of dementia was Alzheimer (male 1.5%, female 1.5%) followed by vascular (male 1.2%, female 0.6%) and others 0.6% (male 0%, female 0.6%). Conclusions: Study showed that a very high percentage of rural elderly attending health camps had poor cognitive function score; though the prevalence of dementia was relatively low. Alzheimer dementia was most common, followed by vascular dementia, which was predominant in males. Illiteracy, age, and under-nutrition were the most important risk factors for poor cognitive function. Our study suggest that cut-off of HMSE score should be 17 (10th percentile) for illiterate population.

Gambhir, Indarjeet Singh; Khurana, Vishal; Kishore, Dhiraj; Sinha, Ashutosh K.; Mohapatra, S. C.

2014-01-01

244

RET/PTC Translocations and Clinico-Pathological Features in Human Papillary Thyroid Carcinoma  

PubMed Central

Thyroid carcinoma is the most frequent endocrine cancer accounting for 5–10% of thyroid nodules. Papillary histotype (PTC) is the most prevalent form accounting for 80% of all thyroid carcinoma. Although much is known about its epidemiology, pathogenesis, clinical, and biological behavior, the only documented risk factor for PTC is the ionizing radiation exposure. Rearrangements of the Rearranged during Transfection (RET) proto-oncogene are found in PTC and have been shown to play a pathogenic role. The first RET rearrangement, named RET/PTC, was discovered in 1987. This rearrangement constitutively activates the transcription of the RET tyrosine-kinase domain in follicular cell, thus triggering the signaling along the MAPK pathway and an uncontrolled proliferation. Up to now, 13 different types of RET/PTC rearrangements have been reported but the two most common are RET/PTC1 and RET/PTC3. Ionizing radiations are responsible for the generation of RET/PTC rearrangements, as supported by in vitro studies and by the evidence that RET/PTC, and particularly RET/PTC3, are highly prevalent in radiation induced PTC. However, many thyroid tumors without any history of radiation exposure harbor similar RET rearrangements. The overall prevalence of RET/PTC rearrangements varies from 20 to 70% of PTCs and they are more frequent in childhood than in adulthood thyroid cancer. Controversial data have been reported on the relationship between RET/PTC rearrangements and the PTC prognosis. RET/PTC3 is usually associated with a more aggressive phenotype and in particular with a greater tumor size, the solid variant, and a more advanced stage at diagnosis which are all poor prognostic factors. In contrast, RET/PTC1 rearrangement does not correlate with any clinical–pathological characteristics of PTC. Moreover, the RET protein and mRNA expression level did not show any correlation with the outcome of patients with PTC and no correlation between RET/PTC rearrangements and the expression level of the thyroid differentiation genes was observed. Recently, a diagnostic role of RET/PTC rearrangements has been proposed. It can be searched for in the mRNA extracted from cytological sample especially in case with indeterminate cytology. However, both the fact that it can be present in a not negligible percentage of benign cases and the technical challenge in extracting mRNA from cytological material makes this procedure not applicable at routine level, at least for the moment. PMID:22654872

Romei, Cristina; Elisei, Rossella

2012-01-01

245

Otomycosis--a clinico-mycological study and efficacy of mercurochrome in its treatment.  

PubMed

A total of 110 patients of symptomatic otomycosis was investigated, prospectively. Aural swabs were collected on 1st, 7th and 14th day and examined by direct microscopy and culture for fungi. Of these, 80 patients found to be having pure fungal infection, were taken up for mycological and therapeutic study. Fungi belonging to genus Aspergillus were isolated in 76 (95.0%) patients of which Aspergillus niger was the commonest isolate in 46 (57.5%), followed by A. flavus in 27 (33.7%), A. fumigatus in 3 (3.7%), Candida species in 3 (3.7%) and Mucor in 1 (1.2%). The patients were of all age groups but majority were between 21 and 30 years and the male-female ratio was equal. Of the total of 40 male patients, twenty-one were Sikhs using turban. Before developing the symptoms, forty five patients used oil, mixture of oil and garlic juice, antibiotics, steroids, antiseptics or wax solvent as ear drops. Only two patients were diabetic. No patient had fungal infection elsewhere in the body. The patients were called for regular follow-up for three weeks. In forty cases mercurochrome was applied as the antifungal agent after cleaning the external auditory canal, in twenty-three clotrimazole and in rest of the seventeen patients miconazole was used. On 7th day, only 11 (13.7%) patients grew different fungi in culture. They became symptom-free on 14th day and no fungal material could be seen on otoscopy, direct microscopy or culture. Mercurochrome was found to be most effective in these patients. PMID:9008878

Chander, J; Maini, S; Subrahmanyan, S; Handa, A

1996-01-01

246

Diagnosis and clinico-radiological presentation in an aggressive maxillary brown tumour.  

PubMed

Brown's tumour is an uncommon focal giant cell lesion which arises as a result of the effect of increased parathyroid hormone on bone tissues in hyperparathyroidism. The mandible is the predominantly affected site in the maxillofacial area and a maxillary involvement is rare. The severity of the lesion, caused by a Brown's tumour, may lead to evident osteolysis and gross deformity in the maxillofacial region, which suggests the need for making an early diagnosis and giving prompt treatment. We are reporting a male patient who presented with a massive painful swelling in the right maxilla as the first manifestation of primary hyperparathyroidism, caused by a parathyroid adenoma. PMID:24995255

Pati, Abhishek Ranjan; Mubeen; Kr, Vijayalakshmi; Singh, Chandravir

2014-05-01

247

Autoimmune hepatitis, one disease with many faces: Etiopathogenetic, clinico-laboratory and histological characteristics  

PubMed Central

Autoimmune hepatitis (AIH) is an unresolving progressive liver disease of unknown etiology characterized by hypergammaglobulinemia, autoantibodies detection and interface hepatitis. Due to the absence of specific diagnostic markers and the large heterogeneity of its clinical, laboratory and histological features, AIH diagnosis may be potentially difficult. Therefore, in this in-depth review we summarize the substantial progress on etiopathogenesis, clinical, serological and histological phenotypes of AIH. AIH has a global distribution affecting any age, both sexes and all ethnic groups. Clinical manifestations vary from asymptomatic to severe or rarely fulminant hepatitis. Hypergammaglobulinemia with selective elevation of IgG is found in most cases. Autoimmune attack is perpetuated, possibly via molecular mimicry, and favored by the impaired control of T-regulatory cells. Histology (interface hepatitis, emperipolesis and hepatic rosette formation) and autoantibodies detection although not pathognomonic, are still the hallmark for a timely diagnosis. AIH remains a major diagnostic challenge. AIH should be considered in every case in the absence of viral, metabolic, genetic and toxic etiology of chronic or acute hepatitis. Laboratory personnel, hepato-pathologists and clinicians need to become more familiar with disease expressions and the interpretation of liver histology and autoimmune serology to derive maximum benefit for the patient. PMID:25574080

Gatselis, Nikolaos K; Zachou, Kalliopi; Koukoulis, George K; Dalekos, George N

2015-01-01

248

Clinico-radiological profile and nuances in the management of cervicomedullary junction intramedullary tumors  

PubMed Central

Background: Cervicomedullary junction (CMJ) intramedullary tumors comprise of tumors that often pose a surgical challenge even in the present era. Though classified under brainstem glioma CMJ tumors are well amenable for surgical resection and have a good outcome. Various factors are involved in the outcome of these patients following surgery and a proper pre-operative assessment is often required to reduce the morbidity and mortality. Materials and Methods: Patients admitted in the Department of Neurosurgery with a diagnosis of CMJ intramedullary tumors from January 2001 to January 2010 were included in the study. Patients were analyzed retrospectively regarding their symptomatology, clinical findings, radiology and outcome after surgery. All patients underwent pre-operative magnetic resonance imaging (MRI) and post-operatively all were managed in the neurosurgery intensive care unit for days to weeks or as dictated by the clinical condition of the patient. Results: A total of 32 patients were included in the present study. The number of males was 21 (65.6%) and females were 11 (34.4%) respectively. The mean age of presentation was 22.97 ± 9.8 years and the mean duration of pre-operative symptoms was 13.3 ± 12.9 months. The tumor had extension from the CMJ into the cervical region in 17 (53.1%) and into the medullary region in 14 (43.8%) patients. Tumor decompression was done in 9 (28.1%) patients and gross near total excision done in 23 (71.87%) patients. Conclusions: Cervicomedullary tumors are a subset of tumors quite distinct from the usual brainstem tumors. Patients having predominant cervical involvement present early and have less post-operative deficits. Those with predominantly more medullary involvement present late, hence have a much more morbid outcome. Though closely related to vital neural structures, surgery forms the mainstay of treatment. Adequate pre-operative planning and preparation of the patient along with intense post-operative monitoring and ventilatory assistance as and when required helps in a good surgical outcome. PMID:24891886

Nair, Anup P.; Mehrotra, Anant; Das, Kuntal Kanti; Srivastava, Arun K.; Sahu, Rabi Narayan; Kumar, Raj

2014-01-01

249

A new clinico-pathological classification system for mesial temporal sclerosis  

PubMed Central

We propose a histopathological classification system for hippocampal cell loss in patients suffering from mesial temporal lobe epilepsies (MTLE). One hundred and seventy-eight surgically resected specimens were microscopically examined with respect to neuronal cell loss in hippocampal subfields CA1–CA4 and dentate gyrus. Five distinct patterns were recognized within a consecutive cohort of anatomically well-preserved surgical specimens. The first group comprised hippocampi with neuronal cell densities not significantly different from age matched autopsy controls [no mesial temporal sclerosis (no MTS); n = 34, 19%]. A classical pattern with severe cell loss in CA1 and moderate neuronal loss in all other subfields excluding CA2 was observed in 33 cases (19%), whereas the vast majority of cases showed extensive neuronal cell loss in all hippocampal subfields (n = 94, 53%). Due to considerable similarities of neuronal cell loss patterns and clinical histories, we designated these two groups as MTS type 1a and 1b, respectively. We further distinguished two atypical variants characterized either by severe neuronal loss restricted to sector CA1 (MTS type 2; n = 10, 6%) or to the hilar region (MTS type 3, n = 7, 4%). Correlation with clinical data pointed to an early age of initial precipitating injury (IPI < 3 years) as important predictor of hippocampal pathology, i.e. MTS type 1a and 1b. In MTS type 2, IPIs were documented at a later age (mean 6 years), whereas in MTS type 3 and normal appearing hippocampus (no MTS) the first event appeared beyond the age of 13 and 16 years, respectively. In addition, postsurgical outcome was significantly worse in atypical MTS, especially MTS type 3 with only 28% of patients having seizure relief after 1-year follow-up period, compared to successful seizure control in MTS types 1a and 1b (72 and 73%). Our classification system appears suitable for stratifying the clinically heterogeneous group of MTLE patients also with respect to postsurgical outcome studies. PMID:17221203

Pauli, Elisabeth; Clusmann, Hans; Schramm, Johannes; Becker, Albert; Elger, Christian; Merschhemke, Martin; Meencke, Heinz-Joachim; Lehmann, Thomas; von Deimling, Andreas; Scheiwe, Christian; Zentner, Josef; Volk, Benedikt; Romstöck, Johann; Stefan, Hermann; Hildebrandt, Michelle

2007-01-01

250

Towards integrated clinico-genomic models for personalized medicine: combining gene  

E-print Network

effects from several of the drugs. Thus, an ability to identify which drug or combinations of drugs and clinical, to most effectively characterize individual patients and achieve the goal of personalized of personalized medicine--health planning, treatment strategies and drugs customized to the individual patient

West, Mike

251

Correlation between CT Perfusion and Clinico-Pathological Features in Prostate Cancer: A Prospective Study  

PubMed Central

Background The aim of the study was to assess the correlation between computed tomography perfusion (PCT) parameters and PSA levels, Gleason score, and pTNM stage in patients with prostate cancer (PCa). Material/Methods One hundred twenty-five patients with localized PCa were prospectively enrolled in the study. All patients were diagnosed due to suspicious prostate findings and elevated PSA serum levels and underwent PCT followed by core biopsy and radical prostatectomy. Blood flow (BF), blood volume (BV), mean transit time (MTT), and permeability-surface (PS) area product were computed in the suspected PCa area and normal prostatic tissue. Core biopsy followed by prostatectomy was performed 2–4 weeks after PCT. Correlation between PCT findings and PSA levels, Gleason score, and pTNM stage were analyzed. Results The mean age of patients was 64 years. All patients had elevated PSA levels (mean value 6.2 ng/ml). Nineteen patients (15.9%) were at low risk of recurrence, 91 (76.5%) were at moderate risk, and 9 (7.6%) were at high risk according to National Comprehensive Cancer Network criteria. PCa was visible on PCT as focal peripheral CT enhancement in 119 out of 125 patients (sensitivity 95.2%). Significant correlations between BV, BF, and PS values and PSA level were found (p<0.05), as well as a trend for difference between BV, BF, and PS in poorly and moderately differentiated tumors (according to Gleason score) in comparison with highly differentiated PCa (p<0.08). The analysis also revealed a correlation between mean perfusion values and BV, MTT, PS, and pTNM cancer stage (p<0.04). Conclusions Our study suggests that in low- and intermediate- risk patients, PCT parameters correlate with PSA values, Gleason score, and pTNM stage and can be useful for initial tumor staging. PMID:25582437

?uczy?ska, El?bieta; Heinze-Paluchowska, Sylwia; Blecharz, Pawe?; Jereczek-Fossa, Barbara; Petralia, Giuseppe; Bellomi, Massimo; Stelmach, Andrzej

2015-01-01

252

[Clinico-radiographic evaluation of the state of the spine in stomach and duodenal diseases].  

PubMed

Data are given on the condition of the thoracic spine of 465 patients with certain gastric and duodenal diseases. Degenerative-dystrophic lesions (spondylosis deformans and intervertebral osteochondrosis) of the thoracic spine together with osteoarthritis deformans of the costovertebral and costotransverse articulations lead to neurodystrophy of the gastric and duodenal mucosa through chronic stimulation by osteophytes of the thoracic sympathetic ganglia. Disorders of gastric and duodenal motor activity are also important. The attendant reflux gastritis is stipulated by reflux of the intestinal contents into the gastric lumen. Condition of the stomach and duodenum can be improved by relieving changes in the spine. PMID:2716242

Dmitriev, A E; Arapov, N A

1989-01-01

253

[The clinico-bacteriological and pharmacokinetic evaluation of vancomycin in clinical practice].  

PubMed

Clinical application of vancomycin in 24 patients produced a response in 83.3% of the patients. The drug was active against pneumococcal pneumonia, bronchitis, staphylococcal endocarditis and mastitis. Positive pharmacokinetic parameters of the drug allows introduction of the antibiotic 1-2 times daily. PMID:8108803

Orlov, V A; Sokolova, V I; Shenderovich, V A; Troshina, E V

1993-01-01

254

Clinico-radiologic characteristics of long-term survivors of diffuse intrinsic pontine glioma  

PubMed Central

Diffuse intrinsic pontine glioma (DIPG) is the deadliest central nervous system tumor in children. The survival of affected children has remained poor despite treatment with radiation therapy (RT) with or without chemotherapy. We reviewed the medical records of all surviving patients with DIPG treated at our institution between October 1, 1992 and May 31, 2011. Blinded central radiologic review of the magnetic resonance imaging at diagnosis of all surviving patients and 15 controls with DIPG was performed. All surviving patients underwent neurocognitive assessment during follow-up. Five (2.6%) of 191 patients treated during the study period were surviving at a median of 9.3 years from their diagnosis (range, 5.3 to 13.2 years). Two patients were younger than 3 years, one lacked signs of pontine cranial nerve involvement, and three had longer duration of symptoms at diagnosis. One patient had a radiologically atypical tumor and one had a tumor originating in the medulla. All five patients received RT. Chemotherapy was variable among these patients. Neurocognitive assessments were obtained after a median interval of 7.1 years. Three of four patients who underwent a detailed evaluation showed cognitive function in the borderline or mental retardation range. Two patients experienced disease progression at 8.8 and 13 years after diagnosis. A minority of children with DIPG experienced long-term survival with currently available therapies. These patients remained at high risk for tumor progression even after long follow-ups. Four of our long-term survivors had clinical and radiologic characteristics at diagnosis associated with improved outcome. PMID:23813229

Jackson, Sadhana; Patay, Zoltan; Howarth, Robyn; Pai Panandiker, Atmaram S.; Onar-Thomas, Arzu; Gajjar, Amar; Broniscer, Alberto

2013-01-01

255

Clinico-radiologic characteristics of long-term survivors of diffuse intrinsic pontine glioma.  

PubMed

Diffuse intrinsic pontine glioma (DIPG) is the deadliest central nervous system tumor in children. The survival of affected children has remained poor despite treatment with radiation therapy (RT) with or without chemotherapy. We reviewed the medical records of all surviving patients with DIPG treated at our institution between October 1, 1992 and May 31, 2011. Blinded central radiologic review of the magnetic resonance imaging at diagnosis of all surviving patients and 15 controls with DIPG was performed. All surviving patients underwent neurocognitive assessment during follow-up. Five (2.6 %) of 191 patients treated during the study period were surviving at a median of 9.3 years from their diagnosis (range 5.3-13.2 years). Two patients were younger than 3 years, one lacked signs of pontine cranial nerve involvement, and three had longer duration of symptoms at diagnosis. One patient had a radiologically atypical tumor and one had a tumor originating in the medulla. All five patients received RT. Chemotherapy was variable among these patients. Neurocognitive assessments were obtained after a median interval of 7.1 years. Three of four patients who underwent a detailed evaluation showed cognitive function in the borderline or mental retardation range. Two patients experienced disease progression at 8.8 and 13 years after diagnosis. A minority of children with DIPG experienced long-term survival with currently available therapies. These patients remained at high risk for tumor progression even after long follow-ups. Four of our long-term survivors had clinical and radiologic characteristics at diagnosis associated with improved outcome. PMID:23813229

Jackson, Sadhana; Patay, Zoltan; Howarth, Robyn; Pai Panandiker, Atmaram S; Onar-Thomas, Arzu; Gajjar, Amar; Broniscer, Alberto

2013-09-01

256

Clinico-Immunological Profile of Children Infected with HIV Through Vertical Transmission, in Southern India  

PubMed Central

Background: Karnataka, being “High Prevalent State” of southern India, the HIV infection among antenatal women has crossed 1%. There are very few reports available with CD4 count and stage wise clinical spectrum among children. The clinical spectrum among HIV infected infants and children vary in different areas of the world. Hence it is important to know the spectrum of opportunistic infections and their respective CD4 count among HIV infected children of our locality. Materials and Methods: The opportunistic infections among 31 paediatric seropositive patients were evaluated. These all patients were classified as per CDC guide lines into stage I, stage II, and stage III based on CD4 counts of > 1000cells/?l, 500-999 cells/?l,<500cells/?l respectively. The opportunistic infections were diagnosed by standard laboratory investigations. Clinical spectrum presented by each stage children was documented. Results: Children in stage I were 5(16.1%),stage II 14(45.1%) and stage III 12(38.7%). Oral candidiasis (29%) was the commonest, followed by recurrent respiratory tract infection (25.8%), tubercular lymphadenitis (16.1%) and chronic diarrhoea (12.9%). Conclusion: The present study showed the children with higher CD4 count had few infections and children with lower CD4 count presented with multiple opportunistic infections. This study also showed vertical transmission as the sole mode of transmission. PMID:25120978

Bairy, Indira

2014-01-01

257

Portulaca oleracea (purslane): nutritive composition and clinico-pathological effects on Nubian goats  

Microsoft Academic Search

Feeding trials of Portulaca oleracea were conducted in two groups of Nubian goats that received the plant at daily doses of 5g\\/kg BW and ad libitum, respectively. Consumption caused weakness of the fore and hind limbs with inability to stand, greenish watery diarrhoea and polyuria. Hepatonephropathy and enteritis accompanied by alterations in some blood and serum constituents were also observed.

W. A. Obied; E. N. Mohamoud; O. S. A. Mohamed

2003-01-01

258

Clinico-hematological and tissue changes induced by butachlor in male Japanese quail (Coturnix japonica).  

PubMed

The present experiment was executed to determine the pathological effects induced by concurrent feeding of butachlor (chloroacetanilide herbicide) in male Japanese quail. For this purpose mature male quail about 4-5weeks of age were procured from the local market and randomly divided into six equal groups (A-F). Butachlor was mixed in corn oil and administered orally for 30days using crop tube. Four birds from each group were killed at day 10, 20 and 30 of the experiment and blood was collected with and without anticoagulant. The birds in groups (A-D) did not reveal any clinical and behavioral alterations. Clinical signs like watery droppings, dullness, ruffled feather, depression, decrease frequency of crowing, mounting with pen mates and foam production were observed. Maximum intensity of these clinical signs and behavioral alterations were observed in group F throughout the experiment. Significant lower values of erythrocytes, hematocrit percent and hemoglobin were recorded. Significantly increased numbers of erythrocytes with micronuclei, lobed and notched nuclei were observed. Histopathologically, enlarged intertubular space, fewer numbers of round spermatids, necrotic spermatids and admixture of dead spermatids were observed in testes. The results revealed significant increase in serum lactate dehydrogenase (LDH), aspartate transaminase (AST), alanine transaminase (ALT) and urea concentrations. The results of present experimental study indicated that butachlor induces hematobiochemical and testicular changes in birds. PMID:24581384

Hussain, Riaz; Khan, Ahrar; Mahmood, Fazal; Rehan, Sarmad; Ali, Farah

2014-02-01

259

Evaluation of clinico-epidemiological and histopathological features of pityriasis rosea  

PubMed Central

Introduction Pityriasis rosea is a sudden-onset and self limiting disease with specific skin rash. The exact etiology is still not clear. Aim To determine epidemiological, etiological, clinical and histopathological features in pityriasis rosea (PR). Material and methods Fifty two patients (older than 18 years) with PR were included in this study. Patients were examined for epidemiological and etiological features. Biopsy specimens obtained from secondary eruptions were histopathologically evaluated with hematoxylin-eosine and immunohistochemically evaluated with CD3 and CD20 monoclonal antibodies. Results Age range of patients was 18–53, mean age was 29.3 ±9.5 and women-to-men ratio was 1.08/1. Thirty-nine (75%) patients had a history of wearing new clothes, 27 (51.9%) patients had a history of recent respiratory tract infection, 15 (28.8%) patients had a history of recent gastrointestinal infection. Eczematous changes were detected in biopsy materials by histopathological evaluation, and cellular infiltrate was positively stained with pan T-cell marker CD3 and negatively stained with B lymphocyte marker CD20 in all biopsy materials in immunohistochemical examination. Conclusions In our study, frequency of pre-disease infection and prodromal symptoms history were determined to be higher than the results of similar studies in the literature. These higher results suggest that PR may be delayed-type hypersensitivity to an infectious factor. However, positive staining of all biopsy materials with pan T lymphocyte marker CD3 supports the association with cellular immunity. We believe that more extensive studies are needed on this issue. PMID:25254006

Özyürek, Gaye Devrim; Çenesizo?lu, Erol

2014-01-01

260

Clinico-pathological Characteristics of Congenital Pulmonary Lymphangiectasis: Report of Two Cases  

PubMed Central

Congenital pulmonary lymphangiectasis (CPL) is a rare, poorly documented disease, characterized by abnormal dilatation of pulmonary lymphatics without lymphatic proliferation. This disease is seen almost exclusively in infancy and early childhood. It can usually be divided into primary (congenital) and secondary forms. The primary form presents in neonates, and the patients mostly die due to the respiratory distress, shortly after birth. The authors experienced two cases of primary CPL in a 13-day-old male neonate and a one-day-old male neonate, showing prominent lymphatic dilatation in the septal, subpleural, and peri-bronchial tissue throughout both lungs. The latter case was associated with congenital cardiac anomaly including single ventricle. These are unique cases of CPL in Korea of which the diagnosis was established through post-mortem examination. Therefore, the authors report these two cases with primary CPL with a review of the literature. PMID:17728521

Eom, Minseob; Choi, Yoo Duk; Kim, Youn Shin; Cho, Mee-Yon; Lee, Han Young

2007-01-01

261

Clinico-epidemiological study of human fascioliasis in an endemic focus in Dakahlia Governorate, Egypt.  

PubMed

Human fascioliasis is increasing in the Nile Delta particularly in Dakahlia Governorate, where it reached 7.47%. In this study, the tetrad of fascioliasis was established as high eosinophilia (100%), fever (85.6%), painful hepatomegaly (81.93%) and anaemia (100%). The laboratory results showed ESR accelerated in 87%, ALT elevated in 21.5%, AST elevated in 21.9%, S. bilirubin elevated in 16.5%, gamma GT elevated in 80.6%, and SAP elevated in 76.4%. Abdominal ultrasonography showed variable findings, as hepatomegaly, splenomegaly, periportal fibrosis, thickened wall of gall bladder, dilated common bile duct, dilated biliary radicals (partial), dilated common bile duct and biliary radicals (total), Fasciola worms in gall bladder, Fasciola worms in common bile duct, stones in gall bladder, stones in bile duct, cystic lesions in the liver, local lesions in the liver and ascitis. The highest was hepatomegaly in 81.93% of fascioliasis patients and the lowest was biliary dilated radicles (partial) in 0.26%. PMID:11775099

el-Shazly, A M; Soliman, M; Gabr, A; Haseeb, A N; Morsy, A T; Arafa, M A; Morsy, T A

2001-12-01

262

Clinico-epidemiological study of Schistosomiasis mansoni in Waja-Timuga, District of Alamata, northern Ethiopia  

PubMed Central

Background Intestinal schistosomiasis, caused by digenetic trematodes of the genus Schistosoma, is the most prevalent water related disease that causes considerable morbidity and mortality. Although prevalence of Schistosoma mansoni infection has been reported for the present study area, earlier studies have not estimated intensity of infections in relation to periportal fibrosis, which would have been crucial for epidemiological and clinical evaluations. Hence, a community based cross sectional study was conducted from December 2011 to March 2012 to assess prevalence of infection and schistosomal periportal fibrosis in Waja-Timuga, northern Ethiopia. Methods In a cross sectional study involving 371 randomly selected individuals, fresh stool samples were collected and processed by the Kato-Katz method and examined microscopically. Ultrasonography was used to determine status of schistosomal periportal fibrosis and to detect hepatomegaly and/or splenomegaly. Serum was collected for assay of hepatic activity. Statistical analysis was performed using STATA 11 statistical soft ware. P-value <0.05 was reported as statistically significant. Results The prevalence of S.mansoni infection was 73.9%, while the prevalence of schistosomal periportal fibrosis was 12.3% and mean intensity of infection was 234 eggs per gram of stool. Peak prevalence and intensity of S.mansoni infection was documented in the age range of 10–20 years. Among the study individuals, hepatomegaly was recorded in 3.7% and splenomegaly was recorded in 7.4% of the study individuals. Similarly, among the study individuals who had definite periportal fibrosis, 5.9% had elevated liver enzyme levels. Conclusion The high prevalence of Schistosoma mansoni infection and schistosomal periportal fibrosis observed in the study area calls for a periodic deworming program to reduce disease, morbidity and transmission. Preventive chemotherapy complemented with other control measures is highly required for sustainable control of schistosomiasis in the study area. PMID:24690404

2014-01-01

263

Fully digital control of a three phase UPS by VeCon integrated controller  

SciTech Connect

This paper presents a fully digital control technique for voltage-fed three-phase inverters to be used in uninterruptible power supplies. An application-specific digital signal processor (VeCon) is used to attain the regulation of the output voltages, which is maintained also in presence of wide load variations. After a short description of the system, attention is focused on VeCon`s performances and implemented control algorithm. Even if no transformer is used in the power converter, the line-to-neutral voltages are independently controlled thus allowing supply of single-phase or unbalanced loads. An inner current control loop is implemented to provide limitation of the phase currents in case of short circuit and overload. Each current and voltage is controlled by a digital PI regulator. The overall control takes less than 20 {micro}s. Sinusoidal output voltages and well controlled phase currents are attained, as demonstrated by experimental results coming from a 15 kVA prototype.

Rossetto, L.; Malesani, L.; Tenti, P.; Buso, S. [Univ. of Padova (Italy); Pollmann, A. [CEMONT SpA, Rivoli (Italy)

1995-12-31

264

Actitudes Éticas de los estudiantes y egresados en carrera de medicina con metodologías activas  

PubMed Central

El presente estudio tiene por objeto desarrollar un diagnostico de la inserción integrada de la ética en la carrera de medicina brasileña con una metodología de aprendizaje basada en problemas y describir las percepciones de actitudes éticas de los estudiantes y egresados. El diseño metodológico es un estudio de caso, descriptivo y documental, con abordaje cualitativo y cuantitativo. La muestra de esta investigación ha sido constituida por 120 estudiantes y 40 egresados de dos promociones del Curso de Medicina de la ESCS. Este proyecto fue aprobado por el Comité de Ética en Investigación - SES/DF. Los estudiantes y egresados de la ESCS demostraron un buen manejo en el abordaje de los conflictos éticos y respeto a los pacientes. Sin embargo, el análisis de sensibilidad ética mostró una fragilidad en las percepciones y aptitudes inapropiadas de los estudiantes de la carrera de medicina, identificada básicamente en los años iniciales, que necesitan más discusiones sistematizadas sobre los aspectos éticos y bioéticos integrados a las actividades prácticas para estimular y fortalecer la reflexión ética de los estudiantes. PMID:20981242

Novaes, Maria Rita Carvalho Garbi; Novaes, Luiz Carlos Garcez; Guilhem, Dirce; Stepke, Fernando Lolas; Silveira, Carla Cristina Costa; Komatsu, Ricardo Shoiti; Trindade, Eliane Mendonça Vilar; Guiotti, Murilo Galvão

2010-01-01

265

Feeding of grey squirrels (Sciurus carolinensis) with the contraceptive agent DiazaCon™: effect on cholesterol, hematology, and blood chemistry.  

PubMed

Grey squirrels (Sciurus carolinensis) are an invasive species in Britain and Italy. They have replaced native red squirrels (Sciurus vulgaris) throughout most of Britain, and cause damage to trees. Currently, lethal control is used to manage grey squirrel populations in Britain, but nonlethal methods might be more acceptable to the public. One such method is contraception with 20,25-diazacholesterol dihydrochloride (DiazaCon™). DiazaCon™ inhibits the conversion of desmosterol to cholesterol, resulting in increasing desmosterol concentrations and decreasing cholesterol concentrations. Because cholesterol is needed for the synthesis of steroid reproductive hormones, such as progesterone and testosterone, inhibition of cholesterol synthesis indirectly inhibits reproduction. Desmosterol is used as a marker of efficacy in laboratory studies with species that do not reproduce readily in captivity. Grey squirrels were gavaged with a DiazaCon™ solution for 2 days, and then fed DiazaCon™-coated peanuts for an additional 8 days at target doses of 50 and 100 mg DiazaCon™ per kg body weight. There was a significant difference in cholesterol concentrations in the treatment groups compared to the control group. Cholesterol was reduced by ? 40% for 2 months in both treatment groups. There were no differences among groups with respect to blood chemistry and hematology parameters, and mean values are reported. The mean overall dose of DiazaCon™ received was 29.0 ± 1.6 and 55.3 ± 4.3 mg/kg in the low (50 mg/kg) and high dose (100 mg/kg) groups, respectively. DiazaCon™ might provide an effective, acceptable alternative to lethal control. PMID:22182332

Yoder, Christi A; Mayle, Brenda A; Furcolow, Carol A; Cowan, David P; Fagerstone, Kathleen A

2011-12-01

266

Nest destruction elicits indiscriminate con- versus heterospecific brood parasitism in a captive bird.  

PubMed

Following nest destruction, the laying of physiologically committed eggs (eggs that are ovulated, yolked, and making their way through the oviduct) in the nests of other birds is considered a viable pathway for the evolution of obligate interspecific brood parasitism. While intraspecific brood parasitism in response to nest predation has been experimentally demonstrated, this pathway has yet to be evaluated in an interspecific context. We studied patterns of egg laying following experimental nest destruction in captive zebra finches, Taeniopygia guttata, a frequent intraspecific brood parasite. We found that zebra finches laid physiologically committed eggs indiscriminately between nests containing conspecific eggs and nests containing heterospecific eggs (of Bengalese finches, Lonchura striata vars. domestica), despite the con- and heterospecific eggs differing in both size and coloration. This is the first experimental evidence that nest destruction may provide a pathway for the evolution of interspecific brood parasitism in birds. PMID:25512846

Shaw, Rachael C; Feeney, William E; Hauber, Mark E

2014-12-01

267

The new human papillomavirus (HPV) vaccine: pros and cons for pediatric and adolescent health.  

PubMed

The new human papillomavirus (HPV) vaccine is a research breakthrough for pediatric/adolescent health to prevent cervical cancer and related morbidity. The annual heath care cost for the treatment of cervical cancer and genital warts is estimated to be more than three billion dollars a year. The new HPV vaccine has incredible potential to improve reproductive health promotion, reduce health care costs, and close health care disparity gaps. However, issues both for and against the new HPV vaccine, including mandating vaccination, high cost of the vaccine, the short duration of protection offered, and the perceived promotion of sexual activity, cause confusion. Pediatric nurses, including those in advanced practice, benefit by understanding the pros and cons of these issues in advocating for their patients. PMID:19051848

Thomas, Tami L

2008-01-01

268

Multipotent (adult) and pluripotent stem cells for heart regeneration: what are the pros and cons?  

PubMed Central

Heart failure after myocardial infarction is the leading cause of mortality and morbidity worldwide. Existing medical and interventional therapies can only reduce the loss of cardiomyocytes during myocardial infarction but are unable to replenish the permanent loss of cardiomyocytes after the insult, which contributes to progressive pathological left ventricular remodeling and progressive heart failure. As a result, cell-based therapies using multipotent (adult) stem cells and pluripotent stem cells (embryonic stem cells or induced pluripotent stem cells) have been explored as potential therapeutic approaches to restore cardiac function in heart failure. Nevertheless, the optimal cell type with the best therapeutic efficacy and safety for heart regeneration is still unknown. In this review, the potential pros and cons of different types of multipotent (adult) stem cells and pluripotent stem cells that have been investigated in preclinical and clinical studies are reviewed, and the future perspective of stem cell-based therapy for heart regeneration is discussed. PMID:24476362

2013-01-01

269

A new look at the infrared spectrum of the weakly bound CO-N2 complex.  

PubMed

A broad-band (2135-2165 cm(-1)) infrared spectrum of the CO-N2 van der Waals complex is obtained, using a tunable quantum cascade laser to probe a pulsed supersonic expansion from a slit jet source. Analysis of the spectrum results in the characterization of four new 'stacks' of rotational levels for CO-orthoN2 (all in the v(CO) = 1 upper state) and five new stacks for CO-paraN2 (three in the upper state and two in the vCO = 0 lower state). This considerably expands our knowledge of a rather fundamental weakly bound complex and should lead to improved determinations of the intermolecular forces governing interactions between the carbon monoxide and nitrogen molecules. PMID:24090526

Rezaei, Mojtaba; Michaelian, K H; Moazzen-Ahmadi, N; McKellar, A R W

2013-12-19

270

Pro-con debate: etomidate or ketamine for rapid sequence intubation in pediatric patients.  

PubMed

When caring for critically ill children, airway management remains a primary determinant of the eventual outcome. Airway control with endotracheal intubation is frequently necessary. Rapid sequence intubation (RSI) is generally used in emergency airway management to protect the airway from passive regurgitation of gastric contents. Along with a rapid acting neuromuscular blocking agent, sedation is an essential element of RSI. A significant safety concern regarding sedatives is the risk of hypotension and cardiovascular collapse, especially in critically ill patients or those with pre-existing comorbid conditions. Ketamine and etomidate, both of which provide effective sedation with limited effects on hemodynamic function, have become increasingly popular as induction agents for RSI. However, experience and clinical investigations have raised safety concerns associated with both etomidate and ketamine. Using a pro-con debate style, the following manuscript discusses the use of ketamine versus etomidate in RSI. PMID:23118665

Scherzer, Daniel; Leder, Mark; Tobias, Joseph D

2012-04-01

271

Microwave and millimeter wave study of Ortho-N2 states of CO-N2  

NASA Astrophysics Data System (ADS)

Microwave and millimeter wave transitions of the CO-N2 complex were investigated using three different instruments, namely, a pulsed molecular beam Fourier transform microwave spectrometer in the frequency region from 4 to 26 GHz, a microwave-millimeter wave double resonance spectrometer in the frequency regions from 8 to 18 GHz for the microwave and 107-118 GHz for the millimeter wave range, and an OROTRON spectrometer in the frequency range from 107 to 132 GHz. Both a- and b-type transitions associated with the ground-state K=0 levels and the lower K=1 levels of the ortho-N2 states, and with rotational quantum number J up to 19, were measured and analyzed. Nuclear quadrupole hyperfine splittings due to the presence of two equivalent 14N nuclei were resolved and analyzed to give additional information about the angular anisotropy of the interaction potential. The nuclear quadrupole coupling constants obtained are ?aa=0.196 41(52) MHz for K=0 levels, and ?aa=-1.0391(17) MHz, ?bb=0.0633(17) MHz for the lower K=1 levels, respectively. The drastic difference between these two sets of coupling constants suggests that the orientation and motion of the N2 subunit are very different in these two states, and that the complex cannot be adequately described by a semirigid rotor model. In addition, measurements of the rotational spectra of the two new isotopomers containing 13C16O and 13C18O subunits provide further important information about the CO-N2 interaction potential.

Xu, Yunjie; Jäger, Wolfgang; Surin, L. A.; Pak, I.; Panfilov, L. A.; Winnewisser, G.

1999-12-01

272

LISTADO DE CURSOS DE VERANO DISTRIBUIDOS POR SEDE Y POR FECHAS COCENTAINA DISEO DE INSTALACIONES EN EDIFICACIN CON CYPECAD del 16 al 18 de julio de 2012  

E-print Network

EN EDIFICACIÃ?N CON CYPECAD del 16 al 18 de julio de 2012 COCENTAINA EMPRENDE CON Ã?XITO EN INTERNET: CLAVES PARA GENERAR NEGOCIOS ONLINE. del 16 al 20 de julio de 2012 COCENTAINA ORIENTACIÃ?N CON GPS EN EL CAMPO del 19 al 20 de julio de 2012 LA MARINA BENISSA EL ROCK AND ROLL SEGÃ?N SUS MEJORES INTÃ?RPRETES del

Escolano, Francisco

273

NatSci 499 E/F: Integrative Scientific Research (iCons 4; 6 credits) Faculty Contact: Prof. Scott M. Auerbach (iCons Program Director; auerbach@chem.umass.edu) or  

E-print Network

1 NatSci 499 E/F: Integrative Scientific Research (iCons 4; 6 credits) Faculty Contact: Prof. Scott in authentic scientific research in UMass Amherst faculty research laboratories. UMass Amherst offers a rich a capstone research project that identifies and fills a scientific knowledge gap in their chosen theme area

Auerbach, Scott M.

274

Análisis de componentes cognoscitivos y psiquiátricos en pacientes con demencia frontotemporal y alzheimer / Analysis of cognitive and psychiatric components in patients with frontotemporal dementia and Alzheimer.  

E-print Network

??Reyes Gavilán, Pablo Alexander (2010) Análisis de componentes cognoscitivos y psiquiátricos en pacientes con demencia frontotemporal y alzheimer / Analysis of cognitive and psychiatric components… (more)

Reyes Gavilán, Pablo Alexander

2010-01-01

275

ScholarShip programS conSideration given to the following min Sat awardS given  

E-print Network

ScholarShip programS conSideration given to the following min Sat (freShmen) and/or gpa number of awardS given & amount renewable? SCHOLARSHIPS AWARDED THROUGH THE UNIVERSITY HONORS PROGRAM University Honors Program Scholarship Incoming freshmen and transfer students who are intellectually curious

Hutcheon, James M.

276

La Universidad de Alicante premiar el robot hecho por amateurs ms hbil en carreras con otros y pinchando sus globos  

E-print Network

La Universidad de Alicante premiará el robot hecho por amateurs más hábil en carreras con otros y Competición de Robótica Amateur UA, está destinado prioritariamente a estudiantes de esta universidad y forma

Escolano, Francisco

277

Global trade in dairy products involves complex and con-tentious issues. Viewed broadly from the perspective of  

E-print Network

Global trade in dairy products involves complex and con- tentious issues. Viewed broadly from the perspective of "society," there are large benefits from liberalizing trade. Viewed narrowly from the perspective of dairy producers, liberalized trade is desirable only if it expands exports and reduces imports

Radeloff, Volker C.

278

Mecanismos psicofisiológicos implicados en la regulación afectiva y la restricción alimentaria de mujeres con riesgo de padecer bulimia nerviosa  

Microsoft Academic Search

El objetivo del estudio fue conocer el efecto de visualizar imágenes de comida bajo diferentes estados de ánimo y diferentes condiciones de restricción alimentaria en la modulación emocional de dos refle- jos defensivos (sobresalto motor y defensa cardiaca). 72 mujeres con riesgo de padecer bulimia ner- viosa fueron asignadas a dos grupos: 1) un grupo al que se inducía un

Sonia Rodríguez; José Luis Mata; Silvia Moreno; Jaime Vila

2007-01-01

279

Sndrome de Waterhouse-Friderichsen: Ms eficacia en el tratamiento con el uso precoz de Protena-C ?  

E-print Network

Síndrome de Waterhouse-Friderichsen: Más eficacia en el tratamiento con el uso precoz de Proteína uniformizados = ... Introducción: Necesidad de mejora del tratamiento del Síndrome de Waterhouse­ Friderichsen

Manstein, Dietmar J.

280

Genova Silicon Valley 10th Edition Incontro a Economia con Ettore Leale, 29 novembre , ore 17, aula Embriaco  

E-print Network

Genova Silicon Valley 10th Edition Incontro a Economia con Ettore Leale, 29 novembre , ore 17, aula Embriaco E' partito da Genova, nel 2005, il ponte tra Italia e Silicon Valley a beneficio degli studenti social network www.siliconvalleystudytour.com, hanno partecipato alle 9 edizioni del Silicon Valley Study

Robbiano, Lorenzo

281

Analysis of Hook Formation Mechanism in Ultra Low Carbon Steel using CON1D Heat Flow Solidification Model  

E-print Network

Analysis of Hook Formation Mechanism in Ultra Low Carbon Steel using CON1D Heat Flow carbon steel, Continuous casting process, Hook formation, Heat flow, Initial solidification Abstract Subsurface hook formation at the meniscus during the continuous casting of steel slabs is an important cause

Thomas, Brian G.

282

Desarrollo economico de Europa Central en 1950-2002: Modelos econometricos y comparacion con Irlanda, España y Austria  

Microsoft Academic Search

Analizamos el desarrollo económico de cinco países de Europa Central: Polonia, Hungría, República Checa, Eslovenia y Eslovaquia, durante el período 1950-2002. teniendo en cuenta las diferentes etapas de su evolución, en comparación con tres países de Europa Occidental que tenían al comienzo del período analizado niveles similares de renta por habitante, pero que alcanzaron durante las últimas décadas del siglo

Maria-Carmen GUISAN; Eva AGUAYO

2004-01-01

283

Una economía de frontera con el norte Europeo: El desarrollo de Cataluña en los siglos XVIII al XX  

Microsoft Academic Search

El presente ensayo pretende evaluar la contribución que haya podido suponer la condición de territorio de frontera a las particularidades del proceso de desarrollo económico de Cataluña desde el siglo XVIII en adelante. En su mismo nacimiento como espacio político y administrativo diferenciado y con soberanía sobre el territorio, Cataluña fue una frontera o límite: la “Marca Hispánica” que el

Jordi Maluquer de Motes i Bernet

2001-01-01

284

The driver of a sports utility vehicle that overturned last April, killing a Virginia Tech freshman, was con-  

E-print Network

, was con- victed Monday of reckless driving. Jeffrey Stoudt, a sophomore psychology major at Tech in whole- sale value." Virginia tree growers and sell- ers are fearing the worst, said Rick Dungey of the National Christmas Tree Association. "This has got so many consum- ers scared to death," he said. "It

Beex, A. A. "Louis"

285

Adding Photos Lightbox GalleryCon nued 1 .Toad d im agestoM ood le,inyourtexted itor,  

E-print Network

Adding Photos Lightbox GalleryCon nued 1 .Toad d im agestoM ood le,inyourtexted itor, locate,create a com pressed fold er (.z ip) w ithallthe im agesyou w ould like toad d to the Lightbox Gallery. 2.W

Selmic, Sandra

286

have to travel normal to the layer structure. The film thickness must be sufficiently small to keep the con-  

E-print Network

the con- tact resistance low (Fig. 3B). 15. M. Shur, M. Hack, J. G. Shaw, J. Appl. Phys. 66, 3371 (1989); M. Shur and M. Hack, ibid. 55, 3831 (1984). 16. G. Horowitz and P. Delannoy, ibid. 70, 469 (1991

Wang, Zhong L.

287

Cause of injury: Contact with tentacles which con-tain stinging cells that inject venom into the skin.  

E-print Network

JELLYFISH Cause of injury: Contact with tentacles which con- tain stinging cells that inject venom. Prevention: Take care when swimming in areas known to have jellyfish. Tentacles of some species may trail a great distance from the body. Rubber diving suits give protec- tion. Avoid touching jellyfish washed up

288

TECHNOLOGY EVALUATION REPORT: INTERNATIONAL WASTE TECHNOLOGIES/GEO-CON IN SITU STABILIZATION/SOLIDIFICATION - VOLUME IV - UPDATE REPORT  

EPA Science Inventory

The long-term performance tests provide information on the first follow-up sampling and analysis on the SITE program demonstration of the International Waste Technologies additive, and the Geo-Con deep soil mixing equipment. he samples containing PCBs, were collected one year aft...

289

TECHNOLOGY EVALUATION REPORT: INTERNATIONAL WASTE TECHNOLOGIES/GEO-CON IN SITU STABILIZATION/SOLIDIFICATION - VOLUME III - UPDATE REPORT  

EPA Science Inventory

The long-term performance tests provide information on the first follow-up sampling and analysis on the SITE program demonstration of the International Waste Technologies additive, and the Geo-Con deep soil mixing equipment. he samples containing PCBs, were collected one year aft...

290

SITE PROGRAM APPLICATIONS ANALYSIS REPORT, INTERNATIONAL WASTE TECHNOLOGIES/GEO CON IN-SITU STABILIZATION/SOLIDIFICATION  

EPA Science Inventory

An evaluation was performed of the International Waste Technologies (IWT) HWT-20 additive and the Geo-Con, Inc. deep-soil-mixing equipment for an in situ stabilization/solidification process and its applicability as an on-site treatment method for waste site cleanup. emonstration...

291

Advances in the development of quantitative models of foreland basin stratigraphy have outpaced the observational data used to con-  

E-print Network

ABSTRACT Advances in the development of quantitative models of foreland basin stratigraphy have outpaced the observational data used to con- strain the input parameters in such models. Underfilled collision (Dickinson, 1974; Beau- mont, 1981; Allen et al., 1986). The sedimentary infill of foreland basins

292

NOTE PER RICHIESTA DUPLICATO PERGAMENA 1. Compilare la domanda di rilascio duplicato pergamena con marca da bollo di  

E-print Network

Sviluppo e Rapporti con le Imprese ­ Servizio Offerta Formativa Post Laurea ­ Piazza Leonardo da Vinci, 32 Offerta Formativa Post Laurea in Piazza Leonardo da Vinci, 32 ­ Padiglione Nord ­ 1° piano ­ Milano Ritiro titolare presso il Servizio Offerta Formativa e Post Laurea in Piazza Leonardo da Vinci, 32 ­ Padiglione

293

Pros and cons of BCG vaccination in countries with low incidence of tuberculosis.  

PubMed

Preventive bacille Calmette-Guérin (BCG) vaccination, together with case finding and effective chemotherapy, has formed an integral part of the tuberculosis (TB) control program in most countries. In some low-incidence countries the balance of prevention has been more on the side of chemoprophylaxis than of BCG vaccination. The time clearly has come when the strategy of mass BCG vaccination no longer is indicated medically, nor is it cost-effective. The pros and cons of the programs need to be critically evaluated against the present epidemiological background, taking into account the facts that TB, the killer disease, is recovering strength, human immunodeficiency virus infection is on the increase, and multidrug-resistant TB has changed the outcome of this previously fully curable disease. Although no longer appropriate for mass programs, BCG vaccination still should be considered for the protection of selected risk groups in low-incidence countries. The overall efficacy may be of the order 50% to 80%, but the variation is great. Therefore, further research urgently is needed on the effectiveness of BCG as an intervention in local TB programs. PMID:7963444

Tala, E O; Tala-Heikkilä, M M

1994-07-01

294

Assessing ComSciCon 2013: A science communication workshop for STEM graduate students (Invited)  

NASA Astrophysics Data System (ADS)

We report on the efficacy of Communicating Science 2013, a science communication workshop for graduate students. Effective science communication is imperative for the sharing of scientific ideas, continued funding and support from policy makers, and education of the public. Science graduate students are a prime group to target for communication training, as they will be our future scientists, educators, and EPO professionals. To this end, Communicating Science 2013 (ComSciCon), a workshop organized by and for STEM graduate students, was held in June of this year. This workshop taught graduate students from around the nation to effectively communicate science to both their peers and the public. To learn about grad students' attitudes toward science communication and establish the workshop's efficacy, we surveyed the participants both before and after the workshop. This assessment probed topics such as communication preparation the participants have already received, how science communication is perceived in their home department, and what participants gained from the workshop. We report the results here.

Kohler, S.; Ranjan, S.; Sanders, N.; Morey, S.

2013-12-01

295

Estereotipos Sexuales y su Relación con Conductas Sexuales Riesgosas1,2,3  

PubMed Central

Resumen Los estereotipos sexuales son creencias generalmente aceptadas y poco cuestionadas que podrían contribuir a cómo los hombres y las mujeres debemos expresar nuestra sexualidad. Los objetivos de este estudio eran identificar cuántos hombres y mujeres heterosexuales en Puerto Rico endosaban ciertos estereotipos acerca de la sexualidad masculina y femenina y explorar la relación entre el endoso de estos estereotipos sexuales y las actitudes hacia el condón masculino y su uso en relaciones sexuales vaginales Llevamos a cabo un estudio descriptivo-correlacional mediante el cual le administramos dos escalas, una sobre sexualidad masculina y otra sobre sexualidad femenina a un grupo de 429 personas heterosexuales. Encontramos que los hombres endosaron estereotipos sexuales masculinos y femeninos más que las mujeres y que estos tienden a tener una visión más conservadora respecto a la sexualidad femenina que la que tienen sobre su propia sexualidad. Las mujeres, por otra parte, tienden a ver su propia sexualidad y la sexualidad masculina en términos menos estereotipados y más equitativos. También encontramos que a mayor endoso de creencias tradicionales sobre la sexualidad masculina y femenina, peor la actitud hacia el uso del condón masculino. Sin embargo, el endosar estereotipos sexuales masculinos y/o femeninos no se relacionó con el uso del condón. Estos hallazgos contradicen la literatura que sugiere que estos estereotipos sexuales y de género resultan en conductas sexuales de alto riesgo, lo cual tiene implicaciones importantes para el desarrollo e implementación de programas de prevención. PMID:24575164

Pérez-Jiménez, David; Orengo-Aguayo, Rosaura E.

2012-01-01

296

Estudio financiado por los NIH indica un aumento de la supervivencia en hombres con cáncer de próstata metastásico que reciben quimioterapia desde el inicio de la terapia hormonal  

Cancer.gov

Los hombres con cáncer de próstata metastásico sensible a las hormonas que recibieron el fármaco quimioterapéutico docetaxel al inicio de la terapia hormonal convencional vivieron más tiempo que los pacientes que recibieron solo terapia hormonal, de acuerdo con los resultados preliminares de un estudio clínico controlado y aleatorizado patrocinado por los Institutos Nacionales de la Salud (NIH).

297

El control social y su relación con los procesos de formación de capital social y movilidad social: algunos indicios a partir de experiencias en Bogot  

Microsoft Academic Search

Este documento presenta un acercamiento analítico a los posibles efectos provocados por la práctica y el proceso institucional de control social sobre quienes tienen una relación directa o indirecta con estos mecanismos, que se despliegan desde la Contraloría General de la República para cumplir con lo dispuesto en la Constitución Nacional. Estos efectos se establecen a partir de mediciones de

Julián F. Bautista R; Londra T. Niño M; Gemma V. Truke O; Jairo Santander A

2011-01-01

298

Síndrome de Down y cardiopatías congénitas con hipertensión pulmonar severa. Resultados quirúrgicos. Down Syndrome and congenital heart diseases with severe pulmonary hypertension surgical results  

Microsoft Academic Search

RESUMEN La presencia de una hipertensión pulmonar de rango severo es un factor de alto riesgo en el manejo quirúrgico de los pacientes con cardiopatías congénitas, como está demostrado en numerosos estudios referentes a ese tema. El objetivo de este trabajo fue obtener mayor información sobre la evolución posterior a la cirugía cardiaca de los pacientes con Síndrome de Down

Herminia Palenzuela López; Lys Mara; Senra Reyes; Horacio Pérez López; Francisco Carballés García

299

(Con)text-specific effects of visual dysfunction on reading in posterior cortical atrophy.  

PubMed

Reading deficits are a common early feature of the degenerative syndrome posterior cortical atrophy (PCA) but are poorly understood even at the single word level. The current study evaluated the reading accuracy and speed of 26 PCA patients, 17 typical Alzheimer's disease (tAD) patients and 14 healthy controls on a corpus of 192 single words in which the following perceptual properties were manipulated systematically: inter-letter spacing, font size, length, font type, case and confusability. PCA reading was significantly less accurate and slower than tAD patients and controls, with performance significantly adversely affected by increased letter spacing, size, length and font (cursive < non-cursive), and characterised by visual errors (69% of all error responses). By contrast, tAD and control accuracy rates were at or near ceiling, letter spacing was the only perceptual factor to influence reading speed in the same direction as controls, and, in contrast to PCA patients, control reading was faster for larger font sizes. The inverse size effect in PCA (less accurate reading of large than small font size print) was associated with lower grey matter volume in the right superior parietal lobule. Reading accuracy was associated with impairments of early visual (especially crowding), visuoperceptual and visuospatial processes. However, these deficits were not causally related to a universal impairment of reading as some patients showed preserved reading for small, unspaced words despite grave visual deficits. Rather, the impact of specific types of visual dysfunction on reading was found to be (con)text specific, being particularly evident for large, spaced, lengthy words. These findings improve the characterisation of dyslexia in PCA, shed light on the causative and associative factors, and provide clear direction for the development of reading aids and strategies to maximise and sustain reading ability in the early stages of disease. PMID:24841985

Yong, Keir X X; Shakespeare, Timothy J; Cash, Dave; Henley, Susie M D; Warren, Jason D; Crutch, Sebastian J

2014-08-01

300

Do Patient-perceived Pros and Cons of Opioids Predict Sustained Higher-Dose Use?  

PubMed Central

Objectives Chronic opioid therapy (COT) is associated with various adverse outcomes, especially at higher doses, yet little is known about predictors of sustained higher-dose COT. This study aimed to ascertain, among higher-dose COT patients, the association of patient-perceived pros and cons of opioids with continued higher-dose use 1 year later. Methods Patients (N = 1229) in 2 large health plans prescribed ? 50 mg morphine-equivalent dose (MED) per day for chronic non-cancer pain completed a survey assessing opioid benefits and harms. The Prescribed Opioid Difficulties Scale questionnaire assessed psychosocial problems, concerns, benefits, and side effects related to opioid use. Logistic regression models estimated the associations of the reported benefits and problems with higher-dose continuation (? 50 mg MED/d) versus dose reduction (< 50 mg MED/d) 1 year later. Results Over 80% of participants continued higher-dose opioid use at 1 year, regardless of reported problems, concerns, side effects, pain reduction, or perceived helpfulness. Higher scores on the Prescribed Opioid Difficulties Scale Problems subscale (odds ratio = 0.79, 95% confidence interval, 0.68–0.92) and Concerns subscale (odds ratio = 0.76, 95% confidence interval, 0.65–0.90) were negatively associated with higher-dose use 1 year later. Other baseline measures (opioid helpfulness, reduction in pain, number of side effects, and side effect bothersomeness) were not significantly associated with continued higher-dose use. Discussion The large majority of patients continued using higher-dose opioids regardless of baseline characteristics. These findings suggest the difficulty of reducing opioid dose among chronic higher-dose opioid users. PMID:23535150

Thielke, Stephen M.; Turner, Judith A.; Shortreed, Susan M.; Saunders, Kathleen; LeResche, Linda; Campbell, Cynthia I.; Weisner, Constance C.; Korff, Michael V.

2013-01-01

301

GP73 was upregulated in PBMC stimulated with ConA but failed to promote lymphocyte proliferation.  

PubMed

Golgi protein 73-kD (GP73), a type II Golgi transmembrane glycoprotein, is highly expressed in a variety of human diseases, but its physiology and pathology remain unknown. In examining the function of GP73 in the immune system, treatment of human PBMC with ConA significantly increased the intracellular expression of GP73 and its secretion into the culture medium. Two-way MLR and the ConA stimulation assay showed that treatment with purified GP73 protein barely affected the proliferation of PBMC. These results suggest that lymphocyte-secreted GP73 might partially contribute to higher serum GP73 in patients, and secreted GP73 exerts an extremely weak effect on the proliferation of PBMC ex vivo. PMID:25231014

Wang, Fang; Li, Zhaotao; Li, Leike; Hu, Longbo; Xiao, Jing; Su, Zhong; Peng, Tao

2015-03-01

302

Disminución de las tasas de cáncer de seno relacionada con la reducción del uso de terapias de reemplazo hormonal  

Cancer.gov

La tasa de los casos nuevos de cáncer de seno en los Estados Unidos, la cual disminuyó pronunciadamente en 2003, podría estar relacionada con una disminución nacional del uso de terapias de reemplazo hormonal. Las tasas de incidencia de cáncer de seno ajustadas a la edad en mujeres de los Estados Unidos bajaron un 6.7 por ciento en 2003. Durante este mismo período, las recetas médicas para terapias de reemplazo hormonal bajaron rápidamente.

303

Su una teoria bilocale dell’interazione tra una particella con spin 1\\/2 e il campo elettromagnetico  

Microsoft Academic Search

\\u000a Riassunto  Si presenta una teoria bilocale per una particella libera con spin 1\\/2 fondata su una semplice generalizzazione lineare dell’equazione\\u000a di Dirac. Si risolve tale equazione introducendo una condizione di quantizzazione della massa e una nuova condizione supplementare\\u000a che sostituisce la eondizione di Yukawa usata in un precedente lavoro. La generalizzazione della teoria è tale che nelle equazioni\\u000a le coordinate del

E. Minardi

1956-01-01

304

Compacti cations des espaces de con guration dans les sch emas de L. Evain (evain@tonton.univ-angers.fr)  

E-print Network

Compacti#12;cations des espaces de con#12;guration dans les sch#19;emas de Hilbert L. Evain (evain sch#19;ema de Hilbert. Notre d#19;emarche g#19;en#19;eralise et uni#12;e des constructions classiques Schubert-Semple #18;a toute vari#19;et#19;e lisse par l'utilisation de sch#19;emas de Hilbert [LB] et Keel

305

CHILES Con Pol: Probing galaxy evolution, the dark Universe, and cosmic magnetism with a deep 1000 hour Jansky VLA survey  

NASA Astrophysics Data System (ADS)

We recently started a 1000 hour campaign to observe 0.2 square degrees of the COSMOS field in full polarization continuum at 1.4 GHz with the Jansky VLA, as part of a joint program with the spectral line COSMOS HI Large Extragalactic Survey (CHILES). When complete, we expect our CHILES Continuum Polarization (CHILES Con Pol) survey to reach an unprecedented SKA-era sensitivity of 0.7 uJy per 4 arcsecond FWHM beam. Here we present the key goals of CHILES Con Pol, which are to (i) produce a source catalog of legacy value to the astronomical community, (ii) measure differential source counts in total intensity, linear polarization, and circular polarization in order to constrain the redshift and luminosity distributions of source populations, (iii) perform a novel weak lensing study using radio polarization as an indicator of intrinsic alignment to better study dark energy and dark matter, and (iv) probe the unknown origin of cosmic magnetism by measuring the strength and structure of intergalactic magnetic fields in the filaments of large scale structure. The CHILES Con Pol source catalog will be a useful resource for upcoming wide-field surveys by acting as a training set for machine learning algorithms, which can then be used to identify and classify radio sources in regions lacking deep multiwavelength coverage.

Hales, Christopher A.; Chiles Con Pol Collaboration

2014-04-01

306

Integrated Concentration in Science (iCons): Undergraduate Education Through Interdisciplinary, Team-Based, Real-World Problem Solving  

NASA Astrophysics Data System (ADS)

Attitude, Skills, Knowledge (ASK) -- In this order, these are fundamental characteristics of scientific innovators. Through first-hand practice in using science to unpack and solve complex real-world problems, students can become self-motivated scientific leaders. This presentation describes the pedagogy of a recently developed interdisciplinary undergraduate science education program at the University of Massachusetts Amherst focused on addressing global challenges with scientific solutions. Integrated Concentration in Science (iCons) is an overarching concentration program that supplements the curricula provided within each student's chosen major. iCons is a platform for students to perform student-led research in interdisciplinary collaborative teams. With a schedule of one course per year over four years, the cohort of students move through case studies, analysis of real-world problems, development of potential solutions, integrative communication, laboratory practice, and capstone research projects. In this presentation, a track emphasizing renewable energy science is used to illustrate the iCons pedagogical methods. This includes discussion of a third-year laboratory course in renewable energy that is educationally scaffolded: beginning with a boot camp in laboratory techniques and culminating with student-designed research projects. Among other objectives, this course emphasizes the practice of using reflection and redesign, as a means of generating better solutions and embedding learning for the long term.

Tuominen, Mark

2013-03-01

307

Desarrollo de la Escala sobre el Estigma Relacionado con el VIH/SIDA para Profesionales de la Salud mediante el uso de métodos mixtos123  

PubMed Central

El estigma relacionado con el VIH/SIDA continúa siendo un obstáculo para la prevención primaria y secundaria del VIH. Las consecuencias para las personas que viven con la enfermedad han sido muy documentadas y continúan siendo una gran preocupación para las personas que proveen servicios de salud y para aquellas que investigan el tema. Estas consecuencias son preocupantes cuando el estigma emana de profesionales de la salud porque se puede limitar el acceso a los servicios. Uno de los principales obstáculos para la investigación del estigma relacionado con el VIH en Puerto Rico es la falta de instrumentos cuantitativos para evaluar las manifestaciones del estigma entre profesionales de la salud. El objetivo principal de este estudio fue desarrollar y probar las propiedades psicométricas de una escala sobre el estigma relacionado con el VIH/SIDA culturalmente apropiada para personas que proveen servicios de salud puertorriqueñas y desarrollar una versión corta de la escala que pudiera usarse en escenarios clínicos con tiempo limitado. El instrumento desarrollado estuvo basado en evidencia cualitativa recopilada entre profesionales y estudiantes de profesiones de la salud puertorriqueños/as (n=80) y administrado a una muestra de 421 profesionales de la salud en adiestramiento. La escala contenía 12 dimensiones del estigma relacionado con el VIH/SIDA. El análisis cuantitativo corroboró 11 de ellas, teniendo como resultado un instrumento con validez y confiabilidad satisfactoria. Estas dimensiones, a su vez, fueron subcomponentes de un factor de estigma general superior. PMID:20333258

Varas-Díaz, Nelson; Neilands, Torsten B.; Guilamo-Ramos, Vincent; Cintrón Bou, Francheska N.

2009-01-01

308

The role of the 2H4 molecule in the generation of suppressor function in Con A-activated T cells.  

PubMed

The molecular basis for the suppression generated in a concanavalin A (Con A)-activated T cell culture remains unknown. In this study, we have attempted to determine whether the 2H4 and 4B4 molecules on Con A-activated T cells play some role in the generation of suppression by such cells. We have shown that Con A-activated suppressor cells belong to the 2H4+ subset of T cells but not the 4B4+ (2H4-) subset. Con A-activated T cells exerted their optimal suppressor function on day 2 in culture, a time at which the expression of 2H4 on such cells was maximal and 4B4 was minimal. Furthermore, the stimulation of T cells with the higher concentration of Con A generated the stronger suppressor function. At the same time, both 2H4 expression and density were increased and 4B4 expression and density were decreased on such Con A-activated T cells. More importantly, the treatment of Con A-activated T cells with anti-2H4 antibody but not with anti-4B4, anti-TQ1, or anti-T4 antibodies can block the suppressor function of such cells. Taken together, the above results strongly suggest that the 2H4 molecule itself may be involved in the generation of suppressor function in Con A-activated T cells. The 2H4 antigen on such cells was shown to be comprised of 220,000 and 200,000 m.w. glycoproteins. Thus this study indicates that the 220,000 and 200,000 m.w. structure of the 2H4 molecule may itself play a crucial role in the generation of suppressor signals of Con A-activated cells. PMID:2945865

Morimoto, C; Letvin, N L; Rudd, C E; Hagan, M; Takeuchi, T; Schlossman, S F

1986-11-15

309

Fuentes de variabilidad en el diagnóstico de gastritis atrófica multifocal asociada con la infección por Helicobacter pylori1  

PubMed Central

RESUMEN Introducción El mapeo de las diferentes regiones del estómago y el número de fragmentos de mucosa gástrica disponibles para evaluación histopatológica son fuentes importantes de variación en el momento de clasificar y hacer la gradación de la gastritis crónica. Objetivos Estimar la sensibilidad del número de fragmentos de mucosa gástrica necesarios para establecer los diagnósticos de gastritis atrófica con metaplasia intestinal (MI), displasia y estado de infección por Helicobacter pylori. Además evaluar la variabilidad intra-observador en la clasificación de estas lesiones precursoras del cáncer gástrico. Materiales y métodos En una cohorte de 6 años de seguimiento se evaluaron 1,958 procedimientos de endoscopia realizados por dos gastroenterólogos. En cada procedimiento y de cada participante se obtuvieron 5 biopsias de mucosa gástrica que representaban antro, incisura angularis y cuerpo. Un único patólogo hizo la interpretación histológica de las 5 biopsias y proporcionó un diagnóstico definitivo global que se utilizó como patrón de referencia. Cada fragmento de mucosa gástrica examinado condujo a un diagnóstico individual para cada biopsia que se comparó con el patrón de referencia. La variabilidad intra-observador se evaluó en 127 personas que corresponden a una muestra aleatoria de 20% del total de endoscopias hechas a los 72 meses de seguimiento. Resultados La sensibilidad del diagnóstico de MI y displasia gástrica aumentó de manera significativa con el número de fragmentos de mucosa gástrica evaluados El sitio anatómico de mayor sensibilidad para el diagnóstico de MI y displasia fue la incisura angularis. Para descubrir H. pylori se logró alta sensibilidad con el estudio de un solo fragmento de mucosa gástrica (95.9%) y fue independiente del sitio de obtención de la biopsia. El acuerdo intra-observador para el diagnóstico de gastritis crónica fue 86.1% con valor kappa de 0.79 IC 95% (0.76-0.85). Las biopsias fijadas en alcohol fueron inadecuadas para demostrar H. pylori e interpretar los cambios de displasia. Conclusión El número de fragmentos de mucosa gástrica evaluados, el método de fijación y la región del estómago donde se obtienen las biopsias son factores muy importantes para lograr una correcta clasificación de la gastritis crónica atrófica multifocal. PMID:25267864

Bravo, Luis Eduardo; Bravo, Juan Carlos; Realpe, José Luis; Zarama, Guillermo; Piazuelo, MarÍa Blanca; Correa, Pelayo

2014-01-01

310

DIA HORA AULA CURSO TITULACION ASIGNATURA 13/12/2013 9:00 Ningn Matriculado 1 Comn con II+LADE Introduccin a la Programacin  

E-print Network

Matemáticas 16/12/2013 15:00 Seminario 270 Departamental II 2 Común con II+LADE Fundamentos de Redes de+LADE Introducción a la Programación 18/12/2013 9:00 Ningún Matriculado 1 Común con II+LADE Fundamentos de los:00 Ningún Matriculado 1 Común con II+LADE Fundamentos Físicos de la Informática 09/01/2014 18:00 Ningún

Rey Juan Carlos, Universidad

311

iCons 2 Renewable Energy [NatSci 290IH (2) aka i2e] Spring 2013 Syllabus i2e Faculty Guides  

E-print Network

1 iCons 2 Renewable Energy [NatSci 290IH (2) aka i2e] ­ Spring 2013 Syllabus i2e Faculty Guides Objectives: Students learn to ... in the context of Renewable Energy problems. 1. ... write effectively

Auerbach, Scott M.

312

hI-con1, a factor VII-IgGFc chimeric protein targeting tissue factor for immunotherapy of uterine serous papillary carcinoma  

Microsoft Academic Search

BACKGROUND:Uterine serous papillary adenocarcinoma (USPC) is a highly aggressive variant of endometrial cancer. Human immuno- conjugate molecule (hI-con1) is an antibody-like molecule targeted against tissue factor (TF), composed of two human Factor VII (fVII) as the targeting domain, fused to human immunoglobulin (Ig) G1 Fc as an effector domain. We evaluated hI-con1 potential activity against primary chemotherapy-resistant USPC cell lines

E Cocco; Z Hu; C E Richter; S Bellone; F Casagrande; M Bellone; P Todeschini; G Krikun; D-A Silasi; M Azodi; P E Schwartz; T J Rutherford; N Buza; S Pecorelli; C J Lockwood; A D Santin

2010-01-01

313

Assessment of Response to Lithium Maintenance Treatment in Bipolar Disorder: A Consortium on Lithium Genetics (ConLiGen) Report  

PubMed Central

Objective The assessment of response to lithium maintenance treatment in bipolar disorder (BD) is complicated by variable length of treatment, unpredictable clinical course, and often inconsistent compliance. Prospective and retrospective methods of assessment of lithium response have been proposed in the literature. In this study we report the key phenotypic measures of the “Retrospective Criteria of Long-Term Treatment Response in Research Subjects with Bipolar Disorder” scale currently used in the Consortium on Lithium Genetics (ConLiGen) study. Materials and Methods Twenty-nine ConLiGen sites took part in a two-stage case-vignette rating procedure to examine inter-rater agreement [Kappa (?)] and reliability [intra-class correlation coefficient (ICC)] of lithium response. Annotated first-round vignettes and rating guidelines were circulated to expert research clinicians for training purposes between the two stages. Further, we analyzed the distributional properties of the treatment response scores available for 1,308 patients using mixture modeling. Results Substantial and moderate agreement was shown across sites in the first and second sets of vignettes (??=?0.66 and ??=?0.54, respectively), without significant improvement from training. However, definition of response using the A score as a quantitative trait and selecting cases with B criteria of 4 or less showed an improvement between the two stages (ICC1?=?0.71 and ICC2?=?0.75, respectively). Mixture modeling of score distribution indicated three subpopulations (full responders, partial responders, non responders). Conclusions We identified two definitions of lithium response, one dichotomous and the other continuous, with moderate to substantial inter-rater agreement and reliability. Accurate phenotypic measurement of lithium response is crucial for the ongoing ConLiGen pharmacogenomic study. PMID:23840348

Manchia, Mirko; Adli, Mazda; Akula, Nirmala; Ardau, Raffaella; Aubry, Jean-Michel; Backlund, Lena; Banzato, Claudio EM.; Baune, Bernhard T.; Bellivier, Frank; Bengesser, Susanne; Biernacka, Joanna M.; Brichant-Petitjean, Clara; Bui, Elise; Calkin, Cynthia V.; Cheng, Andrew Tai Ann; Chillotti, Caterina; Cichon, Sven; Clark, Scott; Czerski, Piotr M.; Dantas, Clarissa; Zompo, Maria Del; DePaulo, J. Raymond; Detera-Wadleigh, Sevilla D.; Etain, Bruno; Falkai, Peter; Frisén, Louise; Frye, Mark A.; Fullerton, Jan; Gard, Sébastien; Garnham, Julie; Goes, Fernando S.; Grof, Paul; Gruber, Oliver; Hashimoto, Ryota; Hauser, Joanna; Heilbronner, Urs; Hoban, Rebecca; Hou, Liping; Jamain, Stéphane; Kahn, Jean-Pierre; Kassem, Layla; Kato, Tadafumi; Kelsoe, John R.; Kittel-Schneider, Sarah; Kliwicki, Sebastian; Kuo, Po-Hsiu; Kusumi, Ichiro; Laje, Gonzalo; Lavebratt, Catharina; Leboyer, Marion; Leckband, Susan G.; López Jaramillo, Carlos A.; Maj, Mario; Malafosse, Alain; Martinsson, Lina; Masui, Takuya; Mitchell, Philip B.; Mondimore, Frank; Monteleone, Palmiero; Nallet, Audrey; Neuner, Maria; Novák, Tomás; O’Donovan, Claire; Ösby, Urban; Ozaki, Norio; Perlis, Roy H.; Pfennig, Andrea; Potash, James B.; Reich-Erkelenz, Daniela; Reif, Andreas; Reininghaus, Eva; Richardson, Sara; Rouleau, Guy A.; Rybakowski, Janusz K.; Schalling, Martin; Schofield, Peter R.; Schubert, Oliver K.; Schweizer, Barbara; Seemüller, Florian; Grigoroiu-Serbanescu, Maria; Severino, Giovanni; Seymour, Lisa R.; Slaney, Claire; Smoller, Jordan W.; Squassina, Alessio; Stamm, Thomas; Steele, Jo; Stopkova, Pavla; Tighe, Sarah K.; Tortorella, Alfonso; Turecki, Gustavo; Wray, Naomi R.; Wright, Adam; Zandi, Peter P.; Zilles, David; Bauer, Michael; Rietschel, Marcella; McMahon, Francis J.

2013-01-01

314

pH-sensitive C-ON bond homolysis of alkoxyamines of imidazoline series: a theoretical study.  

PubMed

The pH-dependent kinetics of C-ON bond homolysis reactions of the four alkoxyamines (viz., the derivatives of 2-(4-(dimethylamino)-2-ethyl-5,5-dimethyl-2-(pyridin-4-yl)-2,5-dihydro-1H-imidazol-1-oxyl and 2-(2-carboxyethyl)-5,5-diethyl-2,4-dimethyl-2,5-dihydro-1H-imidazol-1-oxyl) in water solution have been scrutinized using DFT calculations (M06-2X/6-311++G(2df,p) level of theory with the PCM model). On the basis of computations, the experimental results obtained before (J. Org. Chem. 2011, 76, 5558) have been rationalized. The concentration dependence of all possible protonated forms of the four alkoxyamines was obtained from pH measurements. The contributions of particular protonated forms into the overall rate constants of thermolysis were estimated using the DFT calculated Gibbs free energies ?(r)?G of C-ON bond homolysis reactions. The computations revealed that the observed rate constants of thermolysis of the two species at several pH values are dominated by decomposition reactions of two or even three protonated forms. The observed trends in reactivity of the alkoxyamines were mainly attributed to destabilization of the radical products of C-ON bond scission reactions. A linear correlation between the sum of radical stabilization energies (RSEs) of products of thermolysis and the calculated Gibbs free energies of reactions was found for various protonated forms of the species studied. Apart from this, the linear correlation exists between the relative RSE and nitrogen hyperfine constants aN of various protonated forms of the nitroxide radical products. PMID:24804900

Parkhomenko, Dmitriy A; Edeleva, Mariya V; Kiselev, Vitaly G; Bagryanskaya, Elena G

2014-05-22

315

CONS-COCOMAPS: a novel tool to measure and visualize the conservation of inter-residue contacts in multiple docking solutions  

PubMed Central

Background The development of accurate protein-protein docking programs is making this kind of simulations an effective tool to predict the 3D structure and the surface of interaction between the molecular partners in macromolecular complexes. However, correctly scoring multiple docking solutions is still an open problem. As a consequence, the accurate and tedious screening of many docking models is usually required in the analysis step. Methods All the programs under CONS-COCOMAPS have been written in python, taking advantage of python libraries such as SciPy and Matplotlib. CONS-COCOMAPS is freely available as a web tool at the URL: http://www.molnac.unisa.it/BioTools/conscocomaps/. Results Here we presented CONS-COCOMAPS, a novel tool to easily measure and visualize the consensus in multiple docking solutions. CONS-COCOMAPS uses the conservation of inter-residue contacts as an estimate of the similarity between different docking solutions. To visualize the conservation, CONS-COCOMAPS uses intermolecular contact maps. Conclusions The application of CONS-COCOMAPS to test-cases taken from recent CAPRI rounds has shown that it is very efficient in highlighting even a very weak consensus that often is biologically meaningful. PMID:22536965

2012-01-01

316

Pros and Cons of Using Arrays of Small Antennas Versus Large Single Dish Antennas for the Deep Space Network  

NASA Technical Reports Server (NTRS)

This paper briefly describes pros and cons of using arrays of small antennas instead of large single dish antennas for spacecraft telemetry, command, and tracking (TT and C) - communications and navigation (C and N) - and science support that the Deep Space Network (DSN) normally provides. It considers functionality and performance aspects, mainly for TT and C, though it also considers science. It only briefly comments on the cost aspects that seem to favor arrays of small antennas over large single antennas, at least for receiving (downlinks).

Bagri, Durgadas S.

2009-01-01

317

Modelo de accesibilidad de conceptos matematicos aplicados en el curso de Astronomia Descriptiva para estudiantes con impedimentos visuales en la UPR  

NASA Astrophysics Data System (ADS)

Este estudio utiliza metodologia de investigacion cualitativa, con el proposito de describir, analizar y evaluar los procesos de diseno y desarrollo de un modelo de accesibilidad que consiste en estrategias de ensenanza de las matematicas para estudiantes con impedimentos visuales matriculados en el curso de Astronomia Descriptiva en la UPR. Se utilizaron las siguientes estrategias para recopilar la informacion, 1) reflexiones de la investigadora en el proceso de diseno y desarrollo de las lecciones adaptadas, que se registraron en un diario reflexivo. 2) entrevista semiestructurada luego de haber trabajado las lecciones de aprendizaje adaptadas con los participantes. 3) observaciones y notas de la investigadora del trabajo de los participantes. Para obtener la informacion de los participantes se obtuvo los permisos institucionales necesarios; se seleccionaron los participantes y se validaron los instrumentos; se realizo el desarrollo de las lecciones adaptadas con los participantes; y finalmente, se analizo la informacion obtenida. El diseno de las lecciones de aprendizaje adaptadas se hizo siguiendo las recomendaciones curriculares de los temas de matematicas aplicados en el curso de Astronomia Descriptiva realizado por la investigadora durante su semestre de internado. El testimonio de las voces de los participantes se obtuvo del proceso de desarrollo de las lecciones de aprendizaje adaptadas de temas seleccionados de conceptos matematicos requeridos en el curso de Astronomia Descriptiva y de la entrevista semiestructurada con los participantes, luego de haber trabajado las lecciones de aprendizaje. Para el desarrollo de las lecciones de aprendizaje, se utilizaron materiales tactiles adaptados, materiales tactiles disenados y materiales disponibles comercialmente. Los textos de las lecciones se imprimieron en tinta y en Braille. Se exhorta a disenar y desarrollar estrategias de ensenanza accesibles, considerando como recursos para evaluar su efectividad a personas con impedimentos visuales. El utilizar estrategias de aprendizaje accesibles de acuerdo a las necesidades individuales de los estudiantes, contribuye para que los estudiantes con impedimentos visuales descubran, exploren, investiguen y formulen sus propias conclusiones durante su proceso de aprendizaje.

Isidro Villamizar, Gloria Maria

318

Clinico-mycological Profile of Dermatophytosis in a Reference Centre for Leprosy and Dermatological Diseases in Addis Ababa  

Microsoft Academic Search

To assess the clinical and fungal species spectrum of dermatophyte infection in a reference centre in Addis Ababa, 539 dermatological\\u000a patients with signs of dermatophytosis were investigated. Seventy-one percent were female and 29% male, aged 2–66 years (median\\u000a 9). Four hundred-fifteen (77%) had at least one skin lesion. Tinea capitis was diagnosed in 138\\/155 males (89%) as compared to 214\\/384 females

Y. Woldeamanuel; R. Leekassa; E. Chryssanthou; Y. Mengistu; B. Petrini

2006-01-01

319

Inflammatory myofibroblastic tumor of the lung in children: anaplastic lymphoma kinase (ALK) expression and clinico-pathological correlation.  

PubMed

The inflammatory myofibroblastic tumor (IMT) is a rare neoplastic lesion with a high incidence in children and young people, and may arise in lungs, soft tissue, or viscera. It is recognized as a borderline tumor with the possibility to recur, undergo malignant transformation, and metastasize. IMT is composed of fascicles of bland myofibroblastic cells admixed with an inflammatory infiltrate consisting of lymphocytes, plasma cells, and eosinophils. We reviewed pulmonary IMT diagnosed at Garrahan Hospital in Buenos Aires, Argentina, during 12 years and examined the clinical, laboratory, and pathological features as well as molecular genetics. Eight pediatric cases were evaluated with a male-to-female ratio of 5:3 and a median age of 6 years at diagnosis. The most common lung localization was the upper lobe. All cases underwent surgical excision and no local recurrences were found. Five out of eight patients, including two cases with metastatic/multifocal lesions in the central nervous system (CNS), are alive and disease free after a median follow-up of 30 months. Anaplastic lymphoma kinase (ALK) expression was negative in all pulmonary samples by immunohistochemistry (IHC), however, rearrangement for ALK locus by fluorescence in situ hybridization was found in one lung and in two CNS samples. These findings may reflect higher sensitivity of the molecular biologic procedure compare to traditional IHC practice. In our pediatric experience, 25% of patients with lung IMT developed CNS lesions; therefore we consider that CNS screening in these patients should be considered, at diagnosis and later during follow up. PMID:22280150

Siminovich, Mónica; Galluzzo, Laura; López, Jessica; Lubieniecki, Fabiana; de Dávila, María Teresa G

2012-01-01

320

[SAPHO syndrome: clinico-rheumatologic and radiologic differentiation and classification of a patient sample of 86 cases].  

PubMed

Synovitis (inflammatory arthritis), acne (pustulosa), pustulosis (psoriasis, palmoplantar pustulosis), hyperostosis (acquired), and ostitis (bland osteomyelitis) are symptoms forming the acronym SAPHO, which is a syndrome of nosologic heterogeneity. All entities forming the SAPHO syndrome are connected by a non-obligate dermatoskeletal association with an aseptic pustulous character. 86 cases were analyzed clinically, radiologically and by histology/histopathology. 31 adult patients showed the typical triad of pustulosis palmo-plantaris (psoriatica, PPP), sterno-costo-clavicular hyperostosis (SCCH), and "productive" spondylopathy, which we define as entity I. spondarthritis hyperostotica pustulopsoriatica (Spond.hyp.pp). Twelve adolescent and 13 adult patients showed entity no. II: chronic recurrent multifocal osteomyelitis (CRMO), being characterized by non-purulent osteomyelitis of plasma-cell sclerotic type, potentially being a reactive inflammatory process. 50% of the adult patients with CRMO showed PPP. Differentiation between these two entities is possible by detection of ossifying enthesiopathy in cases of Spond. hyp.pp and primarily chronic osteomyelitis in cases of CRMO. Two more entities or abortive forms of group I and II are III: the inflammatory syndrome of the anterior chest-wall (ACW syndrome) and IV: the more productive form of isolated sterno-costoclavicular hyperostosis (SCCH). Both are connected quite frequently to HLA-B-27-independent forms of spondarthritis and to pustulous dermatosis. More rarely we find osteo-articular symptoms in cases of acne pustulosa, which form group V: acne-associated spondarthritis and CRMO in the case of acne. Adult forms of CRMO with different forms of appearance (lumosacro-iliac hyperostosis with retroperitobeal fibrosis, pelvic type with affection of the hip-joint) are described. The immunologic theory of a "reactive osteomyelitis" potentially triggered by saprophytes is described. The inverse acne triad is brought in a context of skin symptoms. A case of intercurrent postpartum symptoms together with ulcerative colitis is described. Three cases of patients with Crohn's disease are described. Clinical features, radiological findings, and histopathological elements are brought together to determine the connections between the different entities and the possibilities of differentiation. With these elements together with bone-scan, it is often not necessary to obtain a bone specimen. Therapeutical possibilities, especially concerning CRMO, are discussed. "SAPHO syndrome" is more a sign-post on the way to a more subtle diagnosis when it comes to hyperostotic, skin-associated diseases, and it needs interdisciplinary work to clear the situation. PMID:10769419

Schilling, F; KesslerS

2000-02-01

321

Clinico-Pathological Caracteristics, Therapeutic Features and Post-operative Course of Colorectal Cancer in Elderly Patients  

PubMed Central

Statement of Problem: Colorectal cancer is predominantly a disease of elderly people and is a major cause of morbidity and mortality in the elderly population. The geriatric colorectal population is a very heterogeneous group, including patients with excellent health status and others with comorbid conditions, functional dependency, and limited life expectancy. On the other hand, the effectiveness of surgery for colorectal cancer depends on it being carried out safely, which allows most patients to return to productive lives, with an improved post-operative life expectancy or at least one that is not diminished by the surgery. Materials and Methods: This work is a descriptive study of a retrospective cohort, based on administrative databases, of all patients with colorectal cancer diagnosed or treated in our institution. We extracted data on sociodemographic characteristics, comorbidity, type of cancer, stage of cancer, type of treatment received, post-operative complications and cause of post-operative death. We compared differences between an elderly group (Group A) (age >75 years) and a group of patients below 75 years (Group B). Results: We found that elderly patients with colorectal cancer were more likely to be operated in emergent conditions, had more non-specific complications and more post-operative mortality than patients below 75 years. On the other hand, tumours stages, tumours characteristics and post-operative specific morbidity have been proved to be similar, both in Group A and Group B patients. Conclusion: These results suggest that surgery is feasible and can be safe for patients above 75 years, but it needs much more evaluation of comorbidities, pre- and post-operative intensive care to avoid post-operative non-specific complications. PMID:24596729

Bouassida, Mahdi; Chtourou, Mohamed Fadhel; Hamzaoui, Lamine; Sassi, Selim; Mighri, Mohamed Mongi; Azzouz, Mohamed M’Saddak; Touinsi, Hassen; Sassi, Sadok

2014-01-01

322

Clinico Hemato Biochemical Findings, Clinical Management, and Production Performance of Bovines with Late Pregnancy Indigestion (Type IV Vagal Indigestion).  

PubMed

This prospective study was conducted on 15 animals (eight buffaloes and seven cows), diagnosed with late pregnancy indigestion. Ten buffaloes and 10 cows served as the control group. The animals were in advanced pregnancy and had partial or complete anorexia, reduced water intake, loss of defecation or scanty faecal output, and mild to moderate dehydration. Heart and respiration rates were increased and rumen motility was reduced. Five animals had persistent tympany and moderate distension of left abdomen, and two animals each had bilateral abdominal distension and papple shaped abdomen. Neutrophil and lymphocyte counts were significantly higher and lower than the control values. Total bilirubin, AST, total protein, globulin, BUN, glucose, and lactate were significantly higher, and chloride and calcium were significantly lower than the control values. Levels of ALP, GGT, albumin, creatinine, cholesterol, triglyceride, fibrinogen, fibrinogen ratio, sodium, potassium, phosphorus, and magnesium did not differ significantly from the control values. Rumen chloride concentration was higher than the reference range. Majority of animals were managed symptomatically until parturition. There was no effect on fetal survival or milk yield in current and subsequent lactation. So, late pregnancy indigestion causes clinical and hemato biochemical alterations which require special consideration when treating diseased animals. PMID:24804149

Hussain, Syed Ashaq; Uppal, Sanjeev Kumar; Sood, Naresh Kumar; Mahajan, Shashi Kant

2014-01-01

323

A clinico-pathological and follow up study of 10 cases of essential type II cryoglobulinaemic neuropathy.  

PubMed Central

Ten patients with essential cryoglobulinaemia type II were examined for peripheral nerve damage. In six cases distal symmetrical nerve involvement was present, while in three other cases abnormalities restricted to single nerves were found. Electrophysiological and morphological data were consistent with axonal damage, the larger myelinated fibres being most affected. Although active signs of vasculitis and immunoperoxidase staining for immunoglobulins were not present, endoneurial vessels were widely damaged, with abnormally thick endothelial cells and redundant basal membranes. These findings, together with a patchy distribution of myelinated fibre loss, suggest ischaemia as a cause of peripheral neuropathy during essential cryoglobulinaemia type II. A follow up examination, performed one year after haematologial remission, revealed that no further peripheral nerve damage had occurred. PMID:2176233

Cavaletti, G; Petruccioli, M G; Crespi, V; Pioltelli, P; Marmiroli, P; Tredici, G

1990-01-01

324

Ocular surface squamous neoplasia – Review of etio-pathogenesis and an update on clinico-pathological diagnosis  

PubMed Central

Ocular surface squamous neoplasia (OSSN) has a varied clinical presentation, the diagnosis of which rests on the histopathological examination of the excised lesion. The term OSSN includes mild dysplasia on one end of the spectrum and invasive squamous cell carcinoma on the other end. This lesion has a multi factorial aetiology with interplay of several factors like exposure to ultraviolet radiation, various chemical carcinogens and viral infections, however role of individual agents is not well understood. With the upsurge of infection with human immunodeficiency virus, a changing trend is seen in the clinical presentation and prognosis of patients of OSSN even in developed countries. Anterior segment optical coherence tomography (OCT) and confocal microscopy, hold promise in in-vivo differentiation of intraepithelial neoplasia from invasive squamous cell carcinoma. Variants of squamous cell carcinoma like Mucoepidermoid carcinoma, spindle cell carcinoma and OSSN associated with HIV infection should be suspected in a case of aggressive clinical presentation of OSSN or with massive and recurrent tumours. Surgery, chemotherapy and immunotherapy are the various treatment modalities which in combination show promising results in aggressive, recurrent and larger tumours. PMID:24227983

Mittal, Ruchi; Rath, Suryasnata; Vemuganti, Geeta Kashyap

2013-01-01

325

Clinico-Pathological Correlation of ?-Catenin and Telomere Dysfunction in Head and Neck Squamous Cell Carcinoma Patients  

PubMed Central

Background: Tumorigenesis is a complex process of accumulated alteration in function of multiple genes and pathways. Wnt signalling pathway is involved in various differentiation events during embryonic development and is conserved in various species. Objective: A multicentre collaborative initiative is undertaken to study the occurrence, prognosis and molecular mechanism of HNSCC (Head and Neck Squamous Cell Carcinoma) which is highly prevalent in eastern parts of India. From a large cohort of HNSCC tissue repository, 67 cases were selected for multi-parametric investigation. Results: 67 cases showed stable ?-catenin expression. We have seen correlation, if any, of the transcription factor - ?-catenin, telomere maintenance and shelterin complex proteins - TRF2, Rap1 and hTert with respect to tumor differentiation and telomere dysfunction. Immunohistochemistry of ?-catenin protein showed stable and high expression in tumor when compared to stroma. MDSCC (Moderately Differentiated Squamous cell carcinoma) cases expressed nuclear expression of ?-catenin in invasive fronts and showed increased genomic instability. Higher frequency of Anaphase bridges was observed ranging from <3% in normal cut margin to 13% in WDSCC (Well differentiated squamous cell carcinoma) and 18% in MDSCC (Moderately differentiated Squamous cell carcinoma). There was significant decrease in telomere length in MDSCC (<4) when compared to the normal cut margin samples (<7). Quantitative Real Time-PCR confirmed a significant correlationship between stable ?-catenin expression and poor clinical and pathological outcome. Conclusion: The Stabilisation and accumulation of ?-catenin was significant and correlated well with de-differentiation process as well as prognosis and therapy outcome of the patients in the cohort. Expression status of molecular markers such as ?-catenin, hTert, TRF2 and RAP1 correlate significantly with the process of tumorigenesis and prognosis and may play a role in therapeutic management of Head and neck patients. PMID:25653721

Padhi, Swatishree; Saha, Arka; Kar, Madhabananda; Ghosh, Chinmoy; Adhya, Amit; Baisakh, Manas; Mohapatra, Nachiketa; Venkatesan, Shriram; Hande, Manoor Prakash; Banerjee, Birendranath

2015-01-01

326

First case report of anaphylaxis caused by Rajgira seed flour (Amaranthus paniculatus) from India: a clinico-immunologic evaluation.  

PubMed

The prevalence of food allergy is reported to be 3-4% in adults and about 6% in children. However food allergy across different countries accounts for 35-50 % all cases of anaphylaxis to foods. In the present study, we have reported a case of anaphylaxis to Amaranth grain (Amaranthus paniculatus) commonly known as Rajgira (Ramdana) in India. A 60 year old female suffered anaphylaxis after consuming Rajgira seed flour generally consumed during fasting. Food allergy to Amaranth seeds is not reported so far. The patient reported to hospital with complaints of itching in mouth, choking throat, redness and swelling of face and burning abdomen within 5 min of consuming Rajgira flour. Clinical and immunological investigations revealed SPT and oral challenge positivity beside high allergen specific IgE in the serum of the patient. Three IgE binding protein fractions were detected in roasted Rajgira seed flour extract which could be considered to be allergenically important for triggering anaphylaxis. PMID:23517398

Kasera, Ramkrashan; Niphadkar, P V; Saran, Aditya; Mathur, Chandni; Singh, A B

2013-03-01

327

Clinico-epidemiological study of sexually transmitted infections in males at a rural-based tertiary care center  

PubMed Central

Background: Sexually transmitted infections (STIs) promote Human immunodeficiency virus (HIV) transmission by augmenting HIV infectiousness and susceptibility. In our society, especially in rural areas, males are common visitors to STI clinic than females who are generally traced as a contact. This difference may be due to the asymptomatic nature of infections in females, lower awareness among women of need for availing medical facilities, or their frequent consultation in gynecological clinics instead of STI clinics. Aim: To determine the prevalence, clinical profile, and the pattern of STIs in males and the prevalence of HIV infection in them at a rural-based tertiary care center. Materials and Methods: A retrospective study of male cases attending STI clinic between January 2008 and December 2009 was carried out. Diseases were diagnosed on the basis of clinical morphology of the lesion, and HIV and Venereal disease research laboratory (VDRL) testing was done in all cases. Results: Of 23 433 male patients presenting at the Skin/VD department, 201 were diagnosed to have STI. Most common age group affected was 25 to 44 years (59.7%). Incidence of STI was high among married individuals (77.2%). Herpes genitalis was most common STI in 49 (24.37%) cases. Viral infections (herpes genitalis, genital warts, and molluscum contagiosum) accounted for 62.2% of cases. Prevalence of HIV in STI was 2.48%. Conclusions: The persistent and recurrent nature of viral infections is responsible for their increasing trend in the current STI scenario. HIV and STIs are perfect examples of epidemiologic synergy as they are core transmitters of each other. STI being higher in married individuals further underlines the importance of contact tracing, counseling, and prompt management of the partners. PMID:22021968

Vora, Rita; Anjaneyan, Gopikrishnan; Doctor, Chirag; Gupta, Rajat

2011-01-01

328

La gestione integrata clinico ambientale: lo spazio come risorsa terapeutica An integrated clinical-environmental management: Space as therapeutic resource  

Microsoft Academic Search

Dementia and Alzheimer's disease in particular, due to their characteristics of duration, complexity and irreversibility, provoke our interest to reflect on how to effectively approach the question of its management. Dealing the natural course of the illness, the aim is to establish care and assistance priorities, re- ducing symptoms and improving relational and emotional exchange between patient and environment. Studies

D. GOLLIN; C. BASSO; J. MCILWRATH; C. GABELLI

329

Clinico-Pathological Profile of Adnexal Torsion Cases: A Retrospective Analysis from A Tertiary Care Teaching Hospital  

PubMed Central

Introduction: Torsion of the adnexa is a rare condition which can be potentially lethal for the women. The clinical presentation can be varied and can be seen in any age group. Understanding the clinical and pathological profile of patients suffering from adenexal torsion can guide the clinicians in diagnosing and managing the condition. Objective: To analyze the clinical and pathological profile of adnexal torsion cases in a tertiary care teaching hospital. Materials and Methods: The study was a retrospective analysis of hospital records. It included all cases of adnexal torsion that underwent laprotomy between January 2007 to December 2012 in a tertiary care teaching hospital. The study was approved by the Institute’s human Ethics Committee. Results: A total of 18 patients were included in the study. Majority (66.7%) of participants were in the reproductive age group. Abdominal pain was the most common symptom seen in 77.8% of patients. The other symptoms were abdominal distension, back ache and dysuria. Majority of the women belonged to Para 2 (44.4%) and Para 3 (27.8%). The proportion of women with one and two LSCS was 11.1% and 16.7% respectively. Tenderness (38.9%), mass (22.2%) were the common per abdomen findings. Perspeculum findings were normal in majority (88.9%) of the participants. About 39.2% of the patients presented with a mass in either fornices or pouch of Douglas on pervaginal examination. The side of lesion was only on right in 9 (50%) , only left in 7(38.9%) and both sides in 2 (11.1%) of cases. On histopathological examination, of the lesions there were mucinous cystadenoma (33.3%) serous cystadenoma (16.7%) and benign cystic teratoma (16.7%) as most common lesions. Conclusion: Adnexal torsion, though a rare clinical condition can present as an emergency most of the times. High index of suspicion is required for diagnosis, as the clinical presentation can be varied. But the diagnosis can be made certain only on the operating table, either by laparoscopy. Avoiding a delay in operating upon the patient will help prevent complications, and aid in conserving the ovary. PMID:25121032

Reddy, Gopireddy Murali Mohan; Subbiah, Vasantha Nagamma; Sathiya, Saktivel; Arjun, Balasubramanian

2014-01-01

330

An Autopsy Study Describing Causes of Death and Comparing Clinico-Pathological Findings among Hospitalized Patients in Kampala, Uganda  

PubMed Central

Background Information on causes of death in HIV-infected patients in Sub-Saharan Africa is mainly derived from observational cohort and verbal autopsy studies. Autopsy is the gold standard to ascertain cause of death. We conducted an autopsy study to describe and compare the clinical and autopsy causes of death and contributory findings in hospitalized HIV-infected and HIV-uninfected patients in Uganda. Methods Between May and September 2009 a complete autopsy was performed on patients that died on a combined infectious diseases gastroenterology ward in Mulago Hospital in Kampala, Uganda. Autopsy cause of death and contributing findings were based on the macro- and microscopic post-mortem findings combined with clinical information. Clinical diagnoses were reported by the ward doctor and classified as confirmed, highly suspected, considered or not considered, based on information derived from the medical chart. Results are reported according to HIV serostatus. Results Fifty-three complete autopsies were performed in 66% HIV-positive, 21% HIV-negative and 13% patients with an unknown HIV serological status. Infectious diseases caused death in 83% of HIV-positive patients, with disseminated TB as the main diagnosis causing 37% of deaths. The spectrum of illness and causes of death were substantially different between HIV-positive and HIV-negative patients. In HIV-positive patients 12% of postmortem diagnoses were clinically confirmed, 27% highly suspected, 16% considered and 45% not considered. In HIV-negative patients 17% of postmortem diagnoses were clinically highly suspected, 42% considered and 42% not considered. Conclusion Autopsy examination remains an important tool to ascertain causes of death particularly in settings with limited access to diagnostic testing during life. HIV-positive patients continue to die from treatable and clinically undiagnosed infectious diseases. Until rapid-point of care testing is available to confirm common infections, empiric treatment should be further investigated. PMID:22432042

Nelson, Ann M.; Mayanja-Kizza, Harriet; Colebunders, Robert; Van Marck, Eric; Manabe, Yukari C.

2012-01-01

331

An eight-year snapshot of geospatial cancer research (2002–2009): clinico-epidemiological and methodological findings and trends  

Microsoft Academic Search

Geographic information systems (GIS) offer a very rich toolbox of methods and technologies, and powerful research tools that\\u000a extend far beyond the mere production of maps, making it possible to cross-link and study the complex interaction of disease\\u000a data and factors originating from a wide range of disparate sources. Despite their potential indispensable role in cancer\\u000a prevention and control programmes,

Dina N. Kamel Boulos; Ramy R. Ghali; Ezzeldin M. Ibrahim; Maged N. Kamel Boulos; Philip AbdelMalik

332

The Clinico-Oncologic Outcomes of Elderly Patients with Glioblastoma after Surgical Resection Followed by Concomitant Chemo-Radiotherapy  

PubMed Central

Background There have been controversies in the treatment of elderly patients with glioblastoma. We introduce the outcome of the treatment of elderly patients with glioblastoma comparing with younger patients. Methods The author's hospital database was used to identify patients with histologically confirmed glioblastoma after surgery between January 2006 and December 2013. Forty-eight patients (control group) were under age 65 and 16 patients (elderly group) were aged 65 years or over at the time of surgery. Results The median age of the elderly group was 71 years and control group was 50 years. Mean number of medical comorbidities was 1.8 in the elderly group vs. 0.5 in the control group. The median progression free survival (PFS) was 5.6 months and the median overall survival (OS) was 19.9 months in all patients. The elderly group had a median PFS of 4.2 months vs. 8 months for the control group (log-rank test, p=0.762). Median OS was 8.2 months in the elderly group vs. 20.9 months in the control group (log-rank test, p=0.457). Major complications occurred in 5 cases (7.8%) for all patients. The ratio of completion of concomitant chemo-radiotherapy (CCRT) was 81.3% and was the same between the two groups. In multivariable analysis, extent of resection (p=0.034) and completion of CCRT (p=0.023) were statistically significant, independent prognostic factors only for PFS in all patients by Cox proportional hazards model. Age was not an independent prognostic factor. As for OS, there was no significant factor. Conclusion Surgical resection and CCRT were well tolerated in elderly patients with glioblastoma, and maximal safe resection followed by timely CCRT could improve clinic-oncologic outcomes. PMID:25408928

Park, Hee-Kwon; Song, Sang Woo

2014-01-01

333

Assessment of clinico-immunological profile of newly diagnosed HIV patients presenting to a teaching hospital of eastern India  

PubMed Central

Background & objectives: Newly diagnosed HIV patients may be asymptomatic or present with a wide range of symptoms related to opportunistic infections, acute seroconversion illness or other medical illnesses. This study was designed to evaluate the socio-demographic parameters, spectrum of the presenting clinical conditions and concurrent immunological status of newly diagnosed HIV patients and document the WHO clinical stages at the time of HIV diagnosis. Methods: This cross-sectional, observational study was undertaken over a 12 month period at a tertiary referral hospital in eastern India. Three hundred sixty consecutive newly diagnosed HIV patients were selected for the study from the HIV clinic and medicine wards of this hospital. Demographic and clinical data and relevant laboratory investigations of the patients were recorded and analyzed. Results: Mean age of patients was 36.38 ± 10.62 yr, while 63.89 per cent were males. The main mode of transmission of HIV for males and females were unprotected exposure to commercial sex (139, 60.44%) and intercourse with HIV seropositive spouses (89, 68.46%), respectively. Fever (104, 28.89%), weight loss (103, 28.61%) and generalized weakness (80, 22.22%) were the predominant symptoms. Overall mean CD4 count was 176.04 ± 163.49 cells/?l (males 142.19 ± 139.33 cells/?l; females 235.92 ± 185.11 cells/?l). Overall, 224 opportunistic infections were documented in 160 patients, opportunistic diarrhoea (44, 12.22%) and pulmonary tuberculosis (39, 10.83%) being the commonest. There were 83 and 133 patients in WHO clinical stages 3 and 4, respectively; 291 (80.83%) patients were eligible for initiation of first-line antiretrovirals at presentation. Interpretation & conclusions: Advanced immunodeficiency and burden of opportunistic infections characterize newly diagnosed HIV patients in eastern India. The physicians should keep in mind that these patients may have more than one clinical condition at presentation. PMID:25109725

Bishnu, Saptarshi; Bandyopadhyay, Dipanjan; Samui, Samiran; Das, Indrani; Mondal, Pradip; Ghosh, Pramit; Roy, Deeptarka; Manna, Sukanta

2014-01-01

334

Clinico Hemato Biochemical Findings, Clinical Management, and Production Performance of Bovines with Late Pregnancy Indigestion (Type IV Vagal Indigestion)  

PubMed Central

This prospective study was conducted on 15 animals (eight buffaloes and seven cows), diagnosed with late pregnancy indigestion. Ten buffaloes and 10 cows served as the control group. The animals were in advanced pregnancy and had partial or complete anorexia, reduced water intake, loss of defecation or scanty faecal output, and mild to moderate dehydration. Heart and respiration rates were increased and rumen motility was reduced. Five animals had persistent tympany and moderate distension of left abdomen, and two animals each had bilateral abdominal distension and papple shaped abdomen. Neutrophil and lymphocyte counts were significantly higher and lower than the control values. Total bilirubin, AST, total protein, globulin, BUN, glucose, and lactate were significantly higher, and chloride and calcium were significantly lower than the control values. Levels of ALP, GGT, albumin, creatinine, cholesterol, triglyceride, fibrinogen, fibrinogen ratio, sodium, potassium, phosphorus, and magnesium did not differ significantly from the control values. Rumen chloride concentration was higher than the reference range. Majority of animals were managed symptomatically until parturition. There was no effect on fetal survival or milk yield in current and subsequent lactation. So, late pregnancy indigestion causes clinical and hemato biochemical alterations which require special consideration when treating diseased animals. PMID:24804149

Hussain, Syed Ashaq; Uppal, Sanjeev Kumar; Sood, Naresh Kumar; Mahajan, Shashi Kant

2014-01-01

335

Clinico-epidemiological profile of poisoned patients in emergency department: A two and half year's single hospital experience  

PubMed Central

Context: Poisoning is a common cause for attending emergency department of hospitals. Aims: To explore the epidemiological characteristics and clinical profile of patients presenting with poisoning in emergency department. Settings and Design: Prospective, cross-sectional, hospital-based study. Materials and Methods: Relevant epidemiological and clinical data from patients, presenting with history/clinical features of poisoning in emergency department of a tertiary care district hospital in India, were collected and analyzed. Statistical Analysis: Data analysis was done by using descriptive and inferential statistical methods: Frequency, percentage, mean, and standard deviation (SD). A two-tailed P < 0.05 was considered to be statistically significant. Results: A total of 4,432 patients with history and/clinical features of poisoning were included in the study. The females clearly outnumbered male patients. Poisoning with suicidal intent was more frequent (81.08%) than accidental (18.92%) (P < 0.0001). Majority of the patients were housewives followed by farmers, businessmen, laborers, and students. The mean time interval between poison consumption and admission to hospital was 6.4 hours (Mean ± SD: 6.4 ± 2.29). Snakebite (31.90%) was the most common cause of poisoning followed by organophosphorus compounds (21.84%), rodenticide (16.49%), alcohol (13.80%), chemicals (9.04%), and drugs (2.3%). The mean GCS (Glasgow Coma Scale) score of the poisoned patients at presentation was 6.85 ± 1.62. Of all the patients included in the study, 3,712 patients (83.76%) survived and 720 patients (16.24%) expired. Conclusions: The current piece of work suggests that most of the poisoning cases involved young age group particularly females. Snakebite and organophosphorus compounds contributed most of the poisoning cases which calls for urgent government initiatives for improvement in proper lighting of the district to prevent snakebite and controlled use of pesticides. PMID:24741492

Banerjee, Indranil; Tripathi, Santanu Kumar; Roy, A Sinha

2014-01-01

336

Survivin expression in ovarian cancer and its correlation with clinico-pathological, surgical and apoptosis-related parameters  

Microsoft Academic Search

We investigated the association of survivin expression with prognosis and other apoptosis-related biological factors in 110 primary ovarian cancer patients admitted to the Division of Gynecologic Oncology, Catholic University of Rome. Immunohistochemistry was performed on formalin-fixed, paraffin-embedded sections by using polyclonal antibody ab469 for survivin, and mouse monoclonal antibodies (clone 124 and DO-7), for bcl-2 and p53, respectively. Cytoplasmic survivin

G Ferrandina; F Legge; E Martinelli; F O Ranelletti; G F Zannoni; L Lauriola; M Gessi; V Gallotta; G Scambia

2005-01-01

337

Disclosure of individual research results in clinico-genomic trials: challenges, classification and criteria for decision-making  

Microsoft Academic Search

While an ethical obligation to report findings of clinical research to trial participants is increasingly recognised, the academic debate is often vague about what kinds of data should be fed back and how such a process should be organised. In this article, we present a classification of different actors, processes and data involved in the feedback of research results pertaining

Regine Kollek; Imme Petersen

2011-01-01

338

ON EFFECT OF HAZARD MAP ON CONS CIOUSNESS OF FLOOD DISASTER PREVENSION OF RESIDENTS WHO EXPERIENCED FLOOD RECENTLY  

NASA Astrophysics Data System (ADS)

In this paper, the effect of the flood hazard map distributed to the residents who experienced flood disasters recently and an effective method for improving consciousness of flood di saster prevention are discussed. The questionnaire surveys were conducted on the residents living in the middle basin of the Nishiki River, Iwakuni city, Yamaguchi Prefecture, before and after the distribution of the hazard map. It is found from this investigation that "knowledge", "att achment", and "crisis", are the main factors in the psychological process related to the flood prevention behavior. The effect of the distribution of the hazard map is judged from the probability of the flood prevention behavior. In addition, it is also found that "knowledge", "flood experiment of T0514", "crisis", "eff ectiveness", "load", and "easy reading of the hazard map", are keys to improve the cons ciousness of flood di saster prevention.

Asai, Koji; Koga, Syota; Sakakibara, Hiroyuki

339

Intraspecific alkaloid variation in ladybird eggs and its effects on con- and hetero-specific intraguild predators.  

PubMed

Egg predation and cannibalism are common phenomena in predatory ladybirds despite the presence of defensive alkaloids. Consumption of heterospecific eggs negatively affects survivorship and development; however, intraspecific variation in quantities of alkaloids and post-ingestion responses to con- and hetero-specific alkaloids, are not well understood. We examined variation in the quantity of alkaloids in eggs of Harmonia axyridis (Pallas), Coccinella septempunctata L., and Hippodamia convergens (Guérin) using gas chromatography-mass spectrometry, and show a link between heterospecific alkaloids and their toxicity and/or costs by feeding high and low alkaloid eggs to first instar H. axyridis and C. septempunctata. The repeatability of alkaloid measurements in eggs in an egg cluster was high; however, the amount of alkaloids varied significantly between egg clutches within and among females. This variation affected egg consumption by C. septempunctata when fed H. axyridis eggs. Harmonia axyridis accumulated their own alkaloid by cannibalism and synthesized it de novo, but C. septempunctata lost some portion of the consumed conspecific alkaloids. Both species lost most of the consumed heterospecific alkaloids, but C. septempunctata died within 3 days. Most H. axyridis survived to the second instar, but C. septempunctata alkaloids led to a significant reduction in weight gain compared to an aphid control. In addition, ingestion of high alkaloid C. septempunctata extended development of H. axyridis compared to the aphid control or conspecific eggs. Harmonia axyridis had greater abilities to process ingested con- and hetero-specific alkaloids compared with C. septempunctata, which may, in part, explain their interspecific interactions in nature. PMID:20049478

Kajita, Yukie; Obrycki, J J; Sloggett, J J; Haynes, K F

2010-06-01

340

Inversor Resonante de Tres Elementos L-LC con Caracteristica Cortocircuitable para Aplicaciones de Calentamiento por Induccion  

NASA Astrophysics Data System (ADS)

Los generadores de calentamiento por induccion son puentes inversores con carga resonante, cuya mision es basicamente crear una corriente sinusoidal de gran amplitud sobre la "bobina de caldeo", que forma parte del tanque resonante. En el interior de esta bobina se introduce la pieza que se desea calentar. EI campo magnetico creado induce corrientes superficiales (corrientes de Foucault) sobre la pieza, que producen su calentamiento. Los tanques resonantes (tambien llamados osciladores) utilizados en la actualidad son el resonante serie y el resonante paralelo. Aunque ya desde hace algun tiempo se vienen construyendo generadores de alta potencia basados en estos dos osciladores, el exito nunca ha. sido completo en ninguno de los dos casos. Tal y como se explica en la introduccion de esta memoria, los puentes inversores utilizados deben operar sobre una carga inductiva (corriente retrasada) para evitar el fenomeno de la recuperacion inversa de sus diodos y la consiguiente ruptura de los transistores. De la restriccion topologica anterior se deduce que el generador paralelo debe conmutar a frecuencias inferiores a la resonancia, y el serie a frecuencias superiores. A esta restriccion topologica hay que unir otra que es exclusiva del calentamiento por induccion: La corriente por la bobina de caldeo debe ser sinusoidal. De no ser asi, resultaria imposible disponer toda la potencia de calentamiento sobre la pieza en el espesor requerido por la aplicacion. Como consecuencia, los inversores no pueden operar por debajo de la frecuencia de resonancia del oscilador, pues en ese caso se amplifican los armonicos de orden superior de la tension/corriente de entrada situados sobre la resonancia, con la consiguiente distorsion de la corriente de salida. La conjuncion de las dos restricciones anteriores obligan al inversor paralelo a funcionar a la frecuencia de resonancia del oscilador. Esto imposibilita un control por variacion de frecuencia, regulandose la potencia desde la seccion de entrada mediante un mayor o menor aporte de corriente al puente. Como consecuencia, la seccion de entrada del paralelo, ya de por si mas voluminosa que lao del serie por el uso de grandes componentes magneticos (bobinas de filtro o de "alisamiento"), result a tambien mas complicada y costosa debido a la necesidad de ser implementada mediante rectificador controlado. Ademas, la regulacion que ofrece el rectificador es pobre, dada su baja frecuencia de conmutacion. En cambio, el circuito serie puede funcionar por encima de la resonancia manteniendo una secuencia de conmutacion sin riesgos de recuperacion inversa y con una corriente de salida practicamente sinusoidal, lo que permite un control de la potencia por variacion de frecuencia. Puesto que la tarea de regulacion se realiza desde el puente inversor, la regulacion resulta mucho mas eficaz y la seccion de entrada se puede implementar mediante un simple rectificador no controlado y un condensador de filtro. (Abstract shortened by UMI.).

Espi Huerta, Jose Miguel

341

AC 2011-376: WIRELESS-INTEGRATED EMBEDDED REAL-TIME CON-TROL: A CASE STUDY IN ADOPTING RESOURCES FOR DEVELOP-  

E-print Network

in areas of control and embedded systems that weaves critical aspects of control systems design with real-timeAC 2011-376: WIRELESS-INTEGRATED EMBEDDED REAL-TIME CON- TROL: A CASE STUDY IN ADOPTING RESOURCES of Engineering. cAmerican Society for Engineering Education, 2011 #12;Wireless-Integrated Embedded Real-Time

342

INTERNATIONAL SERIES IN PURE AND APPLIED PHYSICS LEO N A R D 1. S CHI F F, CON S U L TIN G E D ITO R  

E-print Network

INTERNATIONAL SERIES IN PURE AND APPLIED PHYSICS LEO N A R D 1. S CHI F F, CON S U L TIN G E D ITO of Gases Read Dislocations in Crystals Richtmyer, Kennard, and Lauritsen Introduction to Modern Physics Quantum Theory of Matter Slater Quantum Theory of Atomic Structure, Vol. I Slater Quantum Theory of Atomic

Allen, Jont

343

IEEE TRANSACTIONS ON AUTOMATIC CONTROL, VOL. 57, NO. 10, OCTOBER 2012 2633 [10] G. Tao, X. Ma, and Y. Ling, "Optimal and nonlinear decoupling con-  

E-print Network

. Cha Abstract--A limitation of the original gain-scheduling approaches is that the closed. Huang, "Adaptive wavelet neural network con- trol with hysteresis estimation for piezo-positioning mechanism," IEEE Trans. Neural Netw., vol. 17, no. 2, pp. 432­444, 2006. Simplified Rapid Switching Gain

Rotkowitz, Michael C.

344

CITRIS Workshop on Power Engineering and the Smart Grid The November 22, 2013 CITRIS Workshop on Power Engineering and the Smart Grid con-  

E-print Network

Report CITRIS Workshop on Power Engineering and the Smart Grid The November 22, 2013 CITRIS Workshop on Power Engineering and the Smart Grid con- sidered the intellectual content of, and some first multidisciplinary. 1 #12;· As automatic control mechanisms become more fundamental to grid operation, security

Yoo, S. J. Ben

345

Determinación de la aptitud de uso del suelo para producción de cultivos con fines bioenergéticos en la provincia de Salta (Noroeste Argentino)  

Microsoft Academic Search

RESUMEN El presente trabajo presenta los resultados alcanzados en la determinación de la aptitud de uso del suelo para producción de cultivos con fines bioenergéticos en la provincia de Salta (Argentina). Para este propósito se buscó aunar los criterios de sustentabilidad social, económica, energética y ambiental que definen el desarrollo sostenible de los sistemas bioenergéticos. El objetivo principal del trabajo

Renée Alicia Anschau; María Cad; Stella Carballo; Noelia Flores

2011-01-01

346

Kurt J. Koester To obtain a position that allows me to use my skills and knowledge in materials science to con-  

E-print Network

in materials science to con- duct research and develop new products and technologies. EDUCATION: 2003-2007 University of California, Berkeley Berkeley, CA Doctor of Philosophy, Engineering, Materials Science and Engineering Minors: Bioengineering and Business Administration Master of Engineering, Materials Science

Ritchie, Robert

347

La Meccanica Quantistica e una teoria completa? e quale relazione ha con la Teoria della Relativita? certo sono di#cilmente compatibili come testimoniano i  

E-print Network

Prefazione La Meccanica Quantistica â??e una teoria completa? e quale relazione ha con la Teoria alternativi di fonderle e il grandioso tentativo in atto di formulare una teoria delle stringhe. Questi sono Quantica: non tocca la teoria quantistica dei campi che ha raggiunto il massimo sviluppo dopo gli anni '30

Roma "La Sapienza", Università di

348

Actividades en el mbito de la internacionalizacin y de la movilidad universitaria Continuando con el propsito de fortalecer el grado de internacionalidad de la UIB y de  

E-print Network

Actividades en el ámbito de la internacionalización y de la movilidad universitaria Continuando con programas de movilidad de estudiantes existentes como a iniciar nuevos, al mismo tiempo que se han puesto en marcha las correspondientes convocatorias de movilidad para profesores y personal de administración y

Oro, Daniel

349

Tutores/as Acadmicos/as de Movilidad El Vicedecanato de Relaciones Internacionales y Movilidad (VRIM) cuenta con una red de tutores/as de movilidad  

E-print Network

Tutores/as Académicos/as de Movilidad El Vicedecanato de Relaciones Internacionales y Movilidad (VRIM) cuenta con una red de tutores/as de movilidad cuyas funciones son: Asesorar a los/as estudiantes (tanto propios como acogidos) en la elección de asignaturas que cursarán durante su periodo de movilidad

Escolano, Francisco

350

AbstractThe Kern River Gas Transmission pipeline was con-structed in 1991 to supply natural gas to be used in the thermally  

E-print Network

94 Abstract­The Kern River Gas Transmission pipeline was con- structed in 1991 to supply natural plants were found in the 11 seeded plots. The Kern River Gas Transmission pipeline (KRGT) was constructed California. The pipeline route extended from a point near Opal, Wyoming, through Utah and Nevada to Daggett

351

Transformacin del campus para el desarrollo de un modelo social integral y su interaccin con el entorno territorial Tabla I. Descripcin de las actuaciones del proyecto  

E-print Network

, promociones entre los estudiantes y presencia activa en los actos de graduación, newsletters, redes sociales yTransformación del campus para el desarrollo de un modelo social integral y su interacción con el colectivo de referencia en los ámbitos de ciencias sociales, de la comunicación y de la biomedicina

Geffner, Hector

352

proceedings: Conscmation. Restoraton. and Management ol Tonoises and Tunles-An Intemauonal ConJerence, pp. 383-391 @ 1987 by thc New York Tunlc and Tonorse Society  

E-print Network

Turtle Nesting Areas for Protection and Management fucHeno R. BugcH,l Lnwu-e G. HetsoN,2 AND Menr DRact: The wood turtle, Clemmys insculpta,is a long-lived, semi-aquatic, riverine species that inhabits forcsted list the wood turtle as "Endangered" or "Threatenedr" and it is now listed on Appendix tr of the Con

353

Synthesis of water-soluble Ag?Se QDs as a novel resonance Rayleigh scattering sensor for highly sensitive and selective ConA detection.  

PubMed

Ag2Se quantum dots (QDs) have attracted a lot of interest due to their potential applications in biosensing and bioimaging. A strategy is presented that involves coupling of selenium powder reduction with the binding of silver ions, and thioglycollic acid (TGA) and glycine as stabilizers to obtain ultrasmall Ag2Se QDs at 85 °C in aqueous solution. This strategy avoids high temperatures, high pressures and organic solvents so that water-soluble 3 nm Ag2Se QDs can be directly obtained. The conjugation of ConA to TGA stabilized Ag2Se QDs by hydrogen bonds leads to the adsorption of ConA to Ag2Se QDs and forms the aggregation and leads to the generation of resonance Rayleigh scattering (RRS) as a readout signal for the sensing events. The reaction mechanism of Ag2Se QD RRS enhancement is studied in this work. The resulting RRS sensor enables the detection of ConA with limit of detection reaching 0.08 ?g mL(-1) concentration in a wide linear range from 0.27 ?g mL(-1) to 35 ?g mL(-1). The recovery of spiked ConA in human serum samples ranges from 94% to 106%. The relative standard deviation (RSD) for eleven replicate detections is 3.6%. Our results correlate many important experimental observations and will fuel the further growth of this field. PMID:24957549

Yan, Shuguang; Zhang, Lichun; Tang, Yurong; Lv, Yi

2014-09-01

354

""This talk explains how the con uence of cloud computing and Massive OpenOnline Courses (MOOCs) have allowed us greatly  

E-print Network

""This talk explains how the con uence of cloud computing and Massive OpenOnline Courses (MOOCs explains how the confluence of cloud computing and Massive Open Online Courses (MOOCs) have allowed us software engineering course. Colloquium and Distinguished LECTURE SERIES Myths About MOOCs and Software

Zhou, Yuanyuan

355

474 The american biology Teacher volume 73, no. 8, ocTober 2011 The accumulation of plastic in the oceans is an ever-growing environmental con-  

E-print Network

of plastic in the oceans is an ever-growing environmental con- cern. Plastic debris is a choking debris. Key Words: Ocean pollution; toxicology; ecosystem health; ocean literacy; envi- ronmental science of plastic pollution. They can be modified to be appro- priate for grades 6­10. Oikonos Ecosystem Knowledge

Schladow, S. Geoffrey

356

AVISO EN CONTRA DE ACTOS DISCRIMINATORIOS De conformidad con la Ley de Derechos Humanos del Distrito de Columbia (D.C.) de 1977, segn enmendada,  

E-print Network

AVISO EN CONTRA DE ACTOS DISCRIMINATORIOS De conformidad con la Ley de Derechos Humanos del a medidas disciplinarias. La Ley de Derechos Humanos del Distrito de Columbia (D.C.), Sección 2-1402.31(a discriminar: "Negarle a una persona, de forma directa o indirecta, el derecho a disfrutar a plenitud y

Weaver, Harold A. "Hal"

357

Departamento de Disciplinas Econmicas y Financieras El Departamento de Disciplinas Econmicas y Financieras, con sede en la Facultad de Derecho de la Universidad  

E-print Network

Financieras, con sede en la Facultad de Derecho de la Universidad de Alicante, está compuesto por el área de conocimiento de Derecho Financiero y Tributario que centra su actividad en las facultades de Derecho, Ciencias: Estudios de 1er y 2º Ciclo (a extinguir) Licenciatura en Derecho. Licenciatura Derecho-ADE (DADE

Escolano, Francisco

358

Page 296 Courses: Economics (ECON) Sonoma State University 2013-2014 Catalog eCon 317 introduCtion to eConoMetriCS (4)  

E-print Network

-sectional techniques, time series analysis, simultaneous equation modeling, and forecasting. Applying widely, or equivalents or consent of instructor. eCon 319 MAnAgeriAL eConoMiCS (4) Economic analysis applied the content and applicability of such basic economic concepts as marginality, opportunity costs, and market

Ravikumar, B.

359

To be presented at the Fourth International Workshop on Virtual Rehabilitation, Catalina Island, CA, September 2005. Usability of the Remote Console (ReCon) for Virtual Reality  

E-print Network

, September 2005. Usability of the Remote Console (ReCon) for Virtual Reality Telerehabilitation: Formative. Keywords virtual reality, telerehabilitation, physical therapy, formative evaluation, usability engineering for virtual reality telerehabilitation from a host site to a clinic or a home using real-time patient

New Jersey, University of Medicine and Dentistry of

360

arXiv:submit/0083985[cond-mat.supr-con]29Jul2010 Metastability in a nano-bridge based hysteretic DC-SQUID embedded in  

E-print Network

arXiv:submit/0083985[cond-mat.supr-con]29Jul2010 Metastability in a nano-bridge based hysteretic DC-SQUID study the metastable response of a highly hysteretic DC-SQUID made of a Niobium loop interrupted by two nano-bridges. We excite the SQUID with an alternating current and with direct magnetic flux, and find

Buks, Eyal

361

ConSoil 2005 -Abstract form Title of abstract Alcohol Flushing: Parameter Estimation for a cost efficient in-situ remediation  

E-print Network

alcohols from the aquifer. The removed mixture has to be sent to a treatment plant in order to separateConSoil 2005 - Abstract form Title of abstract Alcohol Flushing: Parameter Estimation for a cost.greiner@iws.uni-stuttgart.de Phone +49 - 711 / 685 4602 Fax +49 - 711 / 685 7020 Topics: Alcohol flushing, in-situ remediation

Cirpka, Olaf Arie

362

Accordo con QdG Teatro Leonardo Soc. Consortile a r.l. Stagione Teatrale 2013/2014 -www.teatroleonardo.it  

E-print Network

, l'accesso al Teatro Leonardo Da Vinci per gli studenti universitari(2) con tesserino universitario e definire a cura di Teatro Leonardo da Vinci, estensibili ad uno o più accompagnatori se indicato. Per tutte dello "Studio U.r.p. "(3). (1) Storia e Informazioni su www.teatroleonardo.it Teatro Leonardo da Vinci

De Cindio, Fiorella

363

Analysis of cancer risk and BRCA1 and BRCA2 mutation prevalence in the kConFab familial breast cancer resource  

PubMed Central

Introduction The Kathleen Cuningham Foundation Consortium for Research into Familial Breast Cancer (kConFab) is a multidisciplinary, collaborative framework for the investigation of familial breast cancer. Based in Australia, the primary aim of kConFab is to facilitate high-quality research by amassing a large and comprehensive resource of epidemiological and clinical data with biospecimens from individuals at high risk of breast and/or ovarian cancer, and from their close relatives. Methods Epidemiological, family history and lifestyle data, as well as biospecimens, are collected from multiple-case breast cancer families ascertained through family cancer clinics in Australia and New Zealand. We used the Tyrer-Cuzick algorithms to assess the prospective risk of breast cancer in women in the kConFab cohort who were unaffected with breast cancer at the time of enrolment in the study. Results Of kConFab's first 822 families, 518 families had multiple cases of female breast cancer alone, 239 had cases of female breast and ovarian cancer, 37 had cases of female and male breast cancer, and 14 had both ovarian cancer as well as male and female breast cancer. Data are currently held for 11,422 people and germline DNAs for 7,389. Among the 812 families with at least one germline sample collected, the mean number of germline DNA samples collected per family is nine. Of the 747 families that have undergone some form of mutation screening, 229 (31%) carry a pathogenic or splice-site mutation in BRCA1 or BRCA2. Germline DNAs and data are stored from 773 proven carriers of BRCA1 or BRCA1 mutations. kConFab's fresh tissue bank includes 253 specimens of breast or ovarian tissue – both normal and malignant – including 126 from carriers of BRCA1 or BRCA2 mutations. Conclusion These kConFab resources are available to researchers anywhere in the world, who may apply to kConFab for biospecimens and data for use in ethically approved, peer-reviewed projects. A high calculated risk from the Tyrer-Cuzick algorithms correlated closely with the subsequent occurrence of breast cancer in BRCA1 and BRCA2 mutation positive families, but this was less evident in families in which no pathogenic BRCA1 or BRCA2 mutation has been detected. PMID:16507150

Mann, Graham J; Thorne, Heather; Balleine, Rosemary L; Butow, Phyllis N; Clarke, Christine L; Edkins, Edward; Evans, Gerda M; Fereday, Sián; Haan, Eric; Gattas, Michael; Giles, Graham G; Goldblatt, Jack; Hopper, John L; Kirk, Judy; Leary, Jennifer A; Lindeman, Geoffrey; Niedermayr, Eveline; Phillips, Kelly-Anne; Picken, Sandra; Pupo, Gulietta M; Saunders, Christobel; Scott, Clare L; Spurdle, Amanda B; Suthers, Graeme; Tucker, Kathy; Chenevix-Trench, Georgia

2006-01-01

364

Status and Progress of a Fault Current Limiting Hts Cable to BE Installed in the con EDISON Grid  

NASA Astrophysics Data System (ADS)

In the last decade, significant advances in the performance of second generation (2G) high temperature superconducting wire have made it suitable for commercially viable applications such as electric power cables and fault current limiters. Currently, the U.S. Department of Homeland Security is co-funding the design, development and demonstration of an inherently fault current limiting HTS cable under the Hydra project with American Superconductor and Consolidated Edison. The cable will be approximately 300 m long and is being designed to carry 96 MVA at a distribution level voltage of 13.8 kV. The underground cable will be installed and energized in New York City. The project is led by American Superconductor teamed with Con Edison, Ultera (Southwire and nkt cables joint venture), and Air Liquide. This paper describes the general goals, design criteria, status and progress of the project. Fault current limiting has already been demonstrated in 3 m prototype cables, and test results on a 25 m three-phase cable will be presented. An overview of the concept of a fault current limiting cable and the system advantages of this unique type of cable will be described.

Maguire, J.; Folts, D.; Yuan, J.; Henderson, N.; Lindsay, D.; Knoll, D.; Rey, C.; Duckworth, R.; Gouge, M.; Wolff, Z.; Kurtz, S.

2010-04-01

365

Air Traffic Management Technology Demonstration-1 Concept of Operations (ATD-1 ConOps), Version 2.0  

NASA Technical Reports Server (NTRS)

This document is an update to the operations and procedures envisioned for NASA s Air Traffic Management (ATM) Technology Demonstration #1 (ATD-1). The ATD-1 Concept of Operations (ConOps) integrates three NASA technologies to achieve high throughput, fuel-efficient arrival operations into busy terminal airspace. They are Traffic Management Advisor with Terminal Metering (TMA-TM) for precise time-based schedules to the runway and points within the terminal area, Controller-Managed Spacing (CMS) decision support tools for terminal controllers to better manage aircraft delay using speed control, and Flight deck Interval Management (FIM) avionics and flight crew procedures to conduct airborne spacing operations. The ATD-1 concept provides de-conflicted and efficient operations of multiple arrival streams of aircraft, passing through multiple merge points, from top-of-descent (TOD) to the Final Approach Fix. These arrival streams are Optimized Profile Descents (OPDs) from en route altitude to the runway, using primarily speed control to maintain separation and schedule. The ATD-1 project is currently addressing the challenges of integrating the three technologies, and their implantation into an operational environment. The ATD-1 goals include increasing the throughput of high-density airports, reducing controller workload, increasing efficiency of arrival operations and the frequency of trajectory-based operations, and promoting aircraft ADS-B equipage.

Baxley, Brian T.; Johnson, William C.; Swenson, Harry N.; Robinson, John E.; Prevot, Tom; Callantine, Todd J.; Scardina, John; Greene, Michael

2013-01-01

366

The Classics, Con Brio  

ERIC Educational Resources Information Center

Sponsored by a consortium of 30 American universities, Rome's Intercollegiate Center for Classical Studies offers a year of study to American undergraduate classics majors. Instructors are also American and normally stay only a year; teaching assistants are always ex-students of the center. Extensive field trips are an important part of the…

Hansen, James

1978-01-01

367

EthicsConRep  

Cancer.gov

The authors also gratefully acknowledge the copy editing assistance of Leslie Alter, MPH and Steve Brown. The Ethical Force Program’s initiative on patient-centered communication is funded in part by the American Medical Association Foundation, The California Endowment, the Commonwealth Fund and the Connecticut Health Foundation.

368

Neo-Conned University  

ERIC Educational Resources Information Center

Censorship, says Australian political theorist John Keane (1991), can "echo within us, take up residence within ourselves, spying on us, a private amanuensis who reminds us never to go too far... It makes us zip our lips, tremble and think twice" (p. 39). It can also make us sick. The author states that this is her argument here: that,…

Jones, Andee

2014-01-01

369

urban ConAgraculture  

Microsoft Academic Search

Current pressures in today’s world caused me to investigate strategies of change in the organization of society to promote a more effi cient existence. Globalization, a movement characterized by the dissemination of economies, ethnicities, media, ideas, technologies, and production; has become today’s reality. The shift from imperialism to globalism has caused a decline in the power and importance of nation

Dale J Luebbert

2009-01-01

370

Verde Sport S.p.A. con il patrocinio di Assicurazioni Generali e il sostegno di Telecom Italia, bandisce un concorso per il conferimento di 6 premi del valore di 1.000 euro ciascuno a favore di laureati in  

E-print Network

e sport (www.mastersbs.it); Impiantistica sportiva (www.mastersbs.it); Doping sportivo, sia comeBIBLIOTECA STEFANO BENETTON Verde Sport S.p.A. con il patrocinio di Assicurazioni Generali e il ciascuno a favore di laureati in Università italiane con tesi su temi riguardanti lo sport o la

Guidoni, Leonardo

371

Esplorazione Della Terra Incognita Della Fisica Nucleare: Nuclei Con Alone, Nuclei "A Grappoli", Nuclei Borromeani e Altre Stranezze Esotiche!  

E-print Network

English: If the current status of theoretical and experimental knowledge in Nuclear Physics could be reduced to a geographical chart or a planisphere, then our epoch would be in some respect comparable to the end of the Medieval age and in other to the beginning of the Reinassance: epochs in which, together with the consolidated knowledge of the Old World, there have been great and revolutionary expeditions as the discovery of America or the periplus of Cape of Good Hope, explorations aimed at reaching the limits that, along the centuries, have lead to more and more engaging scientific discoveries in more and more far away lands, ending only in the twentieth century with the complete mapping of all the continents. Nuclear Physics is living an analogous adventure on the plane of contrast... - Italian: Se lo stato attuale delle conoscenze teoriche e sperimentali della Fisica Nucleare si potesse ridurre a una carta geografica o un mappamondo, allora la nostra epoca si potrebbe paragonare per certi versi alla fine del Medioevo e per altri al Rinascimento: epoche in cui, accanto alla conoscenza consolidata del Vecchio mondo, ci furono grandi e rivoluzionarie spedizioni come la scoperta dell'America o il periplo del Capo di Buona Speranza, esplorazioni geografiche volte al raggiungimento dei limiti che, nel corso dei secoli, hanno portato a scoperte scientifiche sempre pi\\`u avvincenti in terre sempre pi\\`u lontane, culminate solo nel ventesimo secolo con la completa mappatura di tutte le terre emerse. La Fisica Nucleare sta vivendo un'avventura analoga sul piano della contrapposizione tra la conoscenza acquisita sui nuclei stabili e la scoperta delle sorprendenti propriet\\`a esotiche dei nuclei instabili, pi\\`u difficili da produrre, da studiare e da comprendere.

Lorenzo Fortunato

2011-04-04

372

An inevitable wave of prescription drug monitoring programs in the context of prescription opioids: pros, cons and tensions  

PubMed Central

Background In an effort to control non-medical use and/or medical abuse of prescription drugs, particularly prescription opioids, electronic prescription drug monitoring programs (PDMP) have been introduced in North-American countries, Australia and some parts of Europe. Paradoxically, there are simultaneous pressures to increase opioid prescribing for the benefit of individual patients and to reduce it for the sake of public health, and this pressure warrants a delicate balance of appropriate therapeutic uses of these drugs with the risk of developing dependence. This article discusses pros and cons of PDMP in reducing diversion of prescription opioids, without hampering access to those medications for those with genuine needs, and highlights tensions around PDMP implementation. Discussion PDMPs may help alleviate diversion, over-prescription and fraudulent prescribing/dispensing; prompt drug treatment referrals; avoid awkward drug urine test; and inform spatial changes in prescribing practices and help designing tailored interventions. Fear of legal retribution, privacy and data security, potential confusion about addiction and pseudo-addiction, and potential undue pressure of detecting misuse/diversion - are the major problems. There are tensions about unintended consequence of excessive regulatory enforcements, corresponding collateral damages particularly about inadequate prescribing for patients with genuine needs, and mandatory consultation requirements of PDMP. Summary In this era of information technology PDMP is likely to flourish and remain with us for a long time. A clear standard of practice against which physicians’ care will be judged may expedite the utilisation of PDMP. In addition, adequate training on addiction and pain management along with public awareness, point-of-supply data entry from pharmacy, point-of-care real-time access to data, increasing access to addiction treatment and appropriate regulatory enforcement preferably through healthcare administration, together, may help remove barriers to PDMP use. PMID:25127880

2014-01-01

373

reThiNKiNG The BoUNdaries The dUKe MBa--CroSS ConTInenT  

E-print Network

reThiNKiNG The BoUNdaries The dUKe MBa--CroSS ConTInenT #12;develoP GloBal iNsiGhT The duke MBa--cross continent program is designed to help full-time working professionals earn a world- class MBa while building, The duke MBa-- cross continent program builds more than global awareness; it provides the necessary real

Dolbow, John

374

1.0 What is Statistics? 1.1 What is Mathematical Statistics? Random Data Basic Ideas in Statistics 1.2 Fundamental Con Mathematical Statistics  

E-print Network

§1.0 What is Statistics? §1.1 What is Mathematical Statistics? Random Data Basic Ideas in Statistics §1.2 Fundamental Con Mathematical Statistics Zhang, Lixin and Dai, Jialing Course Website: www.math.zju.edu.cn/zlx/teaching.htm #12;§1.0 What is Statistics? §1.1 What is Mathematical Statistics? Random Data Basic Ideas

Zhang, Li-Xin

375

Guided ion beam studies of the reactions of Con+ (n=1-18) with N2: Cobalt cluster mononitride and dinitride bond energies  

NASA Astrophysics Data System (ADS)

The reactions of Con+ (n=1-18) with N2 are measured as a function of kinetic energy over a range of 0-15eV in a guided ion beam tandem mass spectrometer. A variety of Com+, ComN+, and ComN2+ (m?n) product ions are observed, all in endothermic processes, with collision-induced dissociation dominating the products for all clusters. Bond dissociation energies for both cobalt cluster nitrides and dinitrides are derived from threshold analysis of the energy dependence of the endothermic reactions using several different approaches. These values show only a mild dependence on cluster size over the range studied, although the Co13+-N bond energy is relatively weak. The bond energies of Con+-N for larger clusters suggest that a reasonable value for the desorption energy of atomic nitrogen from bulk phase cobalt is 6.3±0.2eV, which is somewhat lower than the only available value in the literature, an estimate based on the enthalpy of formation of bulk cobalt nitride. The trends in the cobalt nitride thermochemistry are also compared to previously determined metal-metal bond energies, D0(Con+-Co), and to D0(Fen+-N). Implications for catalytic ammonia production using cobalt versus iron are discussed.

Liu, Fuyi; Li, Ming; Tan, Lin; Armentrout, P. B.

2008-05-01

376

Frequency and activity of autorosette forming cells in Con-A activated PBL from women with hyperplasia or carcinoma of the endometrium--possible role of estrogens.  

PubMed

In a previous study we showed that endometrial carcinoma (EC) patients have a T cell deficiency manifested in a reduced ability to be stimulated in vitro by PHA and to produce IL-2. In an attempt to understand the mechanism responsible for this alteration we present in this paper a study on T cells characterized by the ability to form rosettes, with human erythrocytes, following Con-A activation (designated auto-rosette forming cells--ARFC). These cells are also known to manifest suppressive activity. We show that the frequency of ARFC in con-A activated peripheral blood leukocytes (PBMC) of EC patients is significantly (2-5 fold) higher than that of healthy age-matched controls or that of patients with stage--I colon or vaginal cancer. Endometrial carcinoma is known to be associated with long term exposure to estrogens unopposed by progestins. Examining the possible role of estrogens in increasing the frequency of ARFC from EC patients, we found that in vitro addition of estradiol to Con-A stimulated PBMC from healthy donors increased the frequency of ARFC to levels found in EC patients. Tamoxifen, an anti estrogen drug, reduced the frequency of the estrogen stimulated ARFC to the original low level. Our results suggest a dual role for estrogen in carcinogenesis as well as in immunomodulation. PMID:1967003

Yron, I; Kalechman, Y; Langer, A; Lidor, I; Luria, B; Luria, H; Ovadia, J; Pardo, Y; Shohat, L

1990-11-01

377

A methodological approach to comparing pros and cons of delocalizing villages: socio-economic and technical issues  

NASA Astrophysics Data System (ADS)

On 7th March 2005, prolonged rainfalls combined with snowfalls activated a wide complex rock slide-earth flow that partly destroyed the village of Cavallerizzo at Cerzeto (Calabria, Southern Italy). Superposed tectonic units made of Palaeozoic metamorphic rocks, overlain by Miocene-Quaternary clastic terrains, crop out in the study area. The main scarp of the landslide developed by a recent normal fault, striking N-S along the western margin of the Crati graben and extended ca. 25 km. In its lower part, the phenomenon evolved in two main earth-flow bodies that extended along minor drainages and then merged along the S. Nicola torrent. The sector affected by the instability actually belongs to a large-scale slope movement: the 2005 activation was in fact only a paroxysmal episode of a long history of slope deformations, noticed in the area since the XVIII century. Warning signs had been recorded for weeks before the collapse, and the threatened area had been put under monitoring by CNR-IRPI. When the movement accelerated, people had already been alerted and evacuated (329 out of 581 inhabitants of Cerzeto were sheltered in nearby villages), thus neither victims nor injured were recorded. As a whole, 124 buildings were severely damaged or destroyed, the main road was interrupted. Immediately after the 7th March 2005 event, the national Department for Civil Protection decided to evaluate the feasibility of delocalizing Cavallerizzo to another site. At this purpose, CNR-IRPI was asked to analysing the "geological suitability" of 3 different sites (Pianette, Amatine, and Colombra), pre-selected by the same Municipality of Cerzeto in accordance to the Civil Protection; the results of the study were completed in early Summer 2005. Between October 2007 and December 2011, a new settlement was realized by the Italian Government, and the houses were delivered to people once living at Cavallerizzo. In the last years, the socio-economic effects of the delocalization of Cavallerizzo have been analysed within the frame of a PhD thesis by one of the authors. The present study focuses on the Cavallerizzo case study to discuss a methodological approach useful to comparing pros and cons of delocalizing villages, aiming at properly considering socio-economic effects in addition to technical issues.

Guadagno, Eleonora; Iovine, Giulio G. R.; Petrucci, Olga; Forciniti, Pinuccia R.

2014-05-01

378

Informe Anual a la Nación sobre el Estado del Cáncer, de 1975 a 2010, con una sección especial sobre la prevalencia de comorbilidad y su efecto en la supervivencia de personas con cáncer de pulmón, seno, próstata o colorrectal: preguntas y respuestas  

Cancer.gov

El Informe Anual a la Nación sobre el Estado del Cáncer (1975 a 2010), mostró un descenso más acelerado que en años anteriores de los índices de mortalidad por cáncer de pulmón. También contiene una sección especial que destaca los efectos significativos que tienen otras enfermedades en la supervivencia de pacientes con cáncer.

379

15-Deoxy-?12,14-prostaglandin J2 Reduces Liver Impairment in a Model of ConA-Induced Acute Hepatic Inflammation by Activation of PPAR? and Reduction in NF-?B Activity  

PubMed Central

Objective. 15-Deoxy-?12,14-prostaglandin J2 (15d-PGJ2) reduces inflammation and has been identified as an anti-inflammatory prostaglandin in numerous animal models. In this study, we investigated both effects of 15d-PGJ2 and its protection mechanism in concanavalin A- (ConA-) induced autoimmune hepatitis in mice. Materials and Methods. In vivo, Balb/C mice were injected with ConA (25?mg/kg) to induce acute autoimmune hepatitis, and 15d-PGJ2 (10??g or 25??g) was administered 1?h before the ConA injection. The histological grade, proinflammatory cytokine levels, and NF-?B and PPAR? activity were determined 6, 12, and 24?h after the ConA injection. In vitro, LO2 cells and RAW264.7 cells were pretreated with 15d-PGJ2 (2??M) 1?h before the stimulation with ConA (30??g/mL). The NF-?B and PPAR? activity were determined 30?min after the ConA administration. Results. Pretreatment with 15d-PGJ2 reduced the pathological effects of ConA-induced autoimmune hepatitis and significantly reduced the levels of cytokines after injection. 15d-PGJ2 activated PPAR?, blocked the degradation of I?B?, and inhibited the translocation of NF-?B into the nucleus. Conclusion. These results indicate that 15d-PGJ2 protects against ConA-induced autoimmune hepatitis by reducing proinflammatory cytokines. This reduction in inflammation may correlate with the activation of PPAR? and the reduction in NF-?B activity. PMID:25120564

Chen, Kan; Li, Jingjing; Wang, Junshan; Xia, Yujing; Dai, Weiqi; Wang, Fan; Shen, Miao; Cheng, Ping; Zhang, Yan; Wang, Chengfen; Yang, Jing; Zhu, Rong; Zhang, Huawei; Zheng, Yuanyuan; Lu, Jie; Fan, Zhuoyi; Zhou, Yingqun; Guo, Chuanyong

2014-01-01

380

Flight Deck Surface Trajectory-based Operations (STBO): Results of Piloted Simulations and Implications for Concepts of Operation (ConOps)  

NASA Technical Reports Server (NTRS)

The results offour piloted medium-fidelity simulations investigating flight deck surface trajectory-based operations (STBO) will be reviewed. In these flight deck STBO simulations, commercial transport pilots were given taxi clearances with time and/or speed components and required to taxi to the departing runway or an intermediate traffic intersection. Under a variety of concept of operations (ConOps) and flight deck information conditions, pilots' ability to taxi in compliance with the required time of arrival (RTA) at the designated airport location was measured. ConOps and flight deck information conditions explored included: Availability of taxi clearance speed and elapsed time information; Intermediate RTAs at intermediate time constraint points (e.g., intersection traffic flow points); STBO taxi clearances via ATC voice speed commands or datal ink; and, Availability of flight deck display algorithms to reduce STBO RTA error. Flight Deck Implications. Pilot RTA conformance for STBO clearances, in the form of ATC taxi clearances with associated speed requirements, was found to be relatively poor, unless the pilot is required to follow a precise speed and acceleration/deceleration profile. However, following such a precise speed profile results in inordinate head-down tracking of current ground speed, leading to potentially unsafe operations. Mitigating these results, and providing good taxi RTA performance without the associated safety issues, is a flight deck avionics or electronic flight bag (EFB) solution. Such a solution enables pilots to meet the taxi route RTA without moment-by-moment tracking of ground speed. An avionics or EFB "error-nulling" algorithm allows the pilot to view the STBO information when the pilot determines it is necessary and when workload alloys, thus enabling the pilot to spread his/her attention appropriately and strategically on aircraft separation airport navigation, and the many other flight deck tasks concurrently required. Surface Traffic Management (STM) System Implications. The data indicate a number of implications regarding specific parameters for ATC/STM algorithm development. Pilots have a tendency to arrive at RTA points early with slow required speeds, on time for moderate speeds, and late with faster required speeds. This implies that ATC/STM algorithms should operate with middle-range speeds, similar to that of non-STBO taxi performance. Route length has a related effect: Long taxi routes increase the earliness with slow speeds and the lateness with faster speeds. This is likely due to the" open-loop" nature of the task in which the speed error compounds over a longer time with longer routes. Results showed that this may be mitigated by imposing a small number oftime constraint points each with their own RTAs effectively tuming a long route into a series of shorter routes - and thus improving RTA performance. STBO ConOps Implications. Most important is the impact that these data have for NextGen STM system ConOps development. The results of these experiments imply that it is not reasonable to expect pilots to taxi under a "Full STBO" ConOps in which pilots are expected to be at a predictable (x,y) airport location for every time (t). An STBO ConOps with a small number of intermediate time constraint points and the departing runway, however, is feasible, but only with flight deck equipage enabling the use of a display similar to the "error-nulling algorithm/display" tested.

Foyle, David C.; Hooey, Becky L.; Bakowski, Deborah L.

2013-01-01

381

On the role of localized surface plasmon resonance in UV-Vis light irradiated Au/TiO2 photocatalysis systems: pros and cons.  

PubMed

The role of localized surface plasmon resonance (LSPR) in UV-Vis light irradiated Au/TiO2 photocatalysis systems has been investigated, and it is demonstrated experimentally for the first time that both pros and cons of LSPR exist simultaneously for this photocatalytic reaction. We have proved that when operating under mixed UV and green light irradiation, the LSPR injected hot electrons (from the Au nanoparticles to TiO2 under green light irradiation) may surmount the Schottky barrier (SB) formed between the Au nanoparticles and TiO2, and flow back into the TiO2. As a result, these electrons may compensate for and even surpass those transferred from TiO2 to the Au nanoparticles, thus accelerating the recombination of UV excited electron-hole pairs in TiO2. This is the negative effect of LSPR. On the other hand, more hot electrons existing on the surface of the Au nanoparticles due to LSPR would favor the photocatalytic reaction, which accompanied by the negative effect dominates the overall photocatalytic performance. The presented results reveal the multi-faceted essence of LSPR in Au/TiO2 structures, and is instructive for the application of metal-semiconductor composites in photocatalysis. Moreover, it is confirmed that the extent to which the above pros and cons of LSPR dominate the overall photocatalytic reaction depends on the intensity ratio of visible to UV light. PMID:25665512

Lin, Zhongjin; Wang, Xiaohong; Liu, Jun; Tian, Zunyi; Dai, Loucheng; He, Beibei; Han, Chao; Wu, Yigui; Zeng, Zhigang; Hu, Zhiyu

2015-02-19

382

Aceptabilidad del diagnóstico rápido casero para HIV entre hombres gay y otros hombres que tienen sexo con hombres (G&HSH) de la Ciudad de Buenos Aires  

PubMed Central

Resumen El uso del diagnóstico rápido para HIV en Argentina, así como otros países de Latinoamérica, ha sido limitado hasta el momento. Este trabajo reporta los resultados provenientes de un estudio cualitativo realizado entre hombres gays y otros hombres que tienen sexo con hombres (G&HSH) de la Ciudad de Buenos Aires, Argentina. El objetivo principal del mismo fue conocer las ventajas y desventajas que los hombres G&HSH perciben en relación al diagnóstico rápido casero para HIV. Se realizaron ocho grupos focales con 73 participantes en los cuales se discutió acerca de las ventajas y desventajas del uso de los diagnósticos rápidos. Las respuestas fueron codificadas utilizando un programa para análisis de datos cualitativos (NVivo) y analizadas temáticamente. Los participantes describieron numerosas ventajas sobre el uso del diagnóstico rápido casero, aunque algunos reportaron importantes preocupaciones dentro de las cuales se destaca la posibilidad de impulsos suicidas si alguien recibe un resultado positivo estando solo. En términos generales se observó una gran aceptabilidad para el uso del diagnóstico rápido si el mismo es realizado por personal de salud en lugares acondicionados para este fin. PMID:25284951

Balán, Iván C.; Carballo-Diéguez, Alex; Marone, Rubén O.; Pando, María A.; Barreda, Victoria; Ávila, María M.

2011-01-01

383

FACTORES SOCIO-ESTRUCTURALES Y EL ESTIGMA HACIA EL VIH/SIDA: EXPERIENCIAS DE PUERTORRIQUEÑOS/AS CON VIH/SIDA AL ACCEDER SERVICIOS DE SALUD  

PubMed Central

RESUMEN El estigma relacionado al VIH/SIDA continúa afectando la prestación de servicios de salud y el bienestar físico y mental de las personas con VIH/SIDA (PVS). Recientemente la literatura científica ha señalado la importancia de comprender las manifestaciones de estigma más allá de las interacciones individuales. Por tal razón, investigaciones recientes en y fuera de Puerto Rico enfatizan la importancia de entender cómo factores socio-estructurales (FSE) influyen en los procesos de estigmatización social. Con el propósito de examinar los FSE que influyen en las manifestaciones de estigma relacionado al VIH/SIDA, realizamos y analizamos nueve grupos focales compuestos por hombres y mujeres en tratamiento para el VIH/SIDA que habían tenido experiencias estigmatizantes. Los participantes identificaron FSE relacionados a las manifestaciones de estigma, tales como el uso de viviendas especializadas, descentralización de los servicios de salud y el desarrollo de protocolos administrativos excluyentes en los servicios de salud. Los resultados demuestran la importancia de considerar los FSE en el desarrollo e implementación de intervenciones dirigidas a la población. PMID:24639599

RIVERA-DIAZ, MARINILDA; VARAS-DIAZ, NELSON; REYES-ESTRADA, MARCOS; SURO, BEATRIZ; CORIANO, DORALIS

2013-01-01

384

The International Consortium on Lithium Genetics (ConLiGen): an initiative by the NIMH and IGSLI to study the genetic basis of response to lithium treatment.  

PubMed

For more than half a decade, lithium has been successfully used to treat bipolar disorder. Worldwide, it is considered the first-line mood stabilizer. Apart from its proven antimanic and prophylactic effects, considerable evidence also suggests an antisuicidal effect in affective disorders. Lithium is also effectively used to augment antidepressant drugs in the treatment of refractory major depressive episodes and prevent relapses in recurrent unipolar depression. In contrast to many psychiatric drugs, lithium has outlasted various pharmacotherapeutic 'fashions', and remains an indispensable element in contemporary psychopharmacology. Nevertheless, data from pharmacogenetic studies of lithium are comparatively sparse, and these studies are generally characterized by small sample sizes and varying definitions of response. Here, we present an international effort to elucidate the genetic underpinnings of lithium response in bipolar disorder. Following an initiative by the International Group for the Study of Lithium-Treated Patients (www.IGSLI.org) and the Unit on the Genetic Basis of Mood and Anxiety Disorders at the National Institute of Mental Health,lithium researchers from around the world have formed the Consortium on Lithium Genetics (www.ConLiGen.org) to establish the largest sample to date for genome-wide studies of lithium response in bipolar disorder, currently comprising more than 1,200 patients characterized for response to lithium treatment. A stringent phenotype definition of response is one of the hallmarks of this collaboration. ConLiGen invites all lithium researchers to join its efforts. PMID:20453537

Schulze, Thomas G; Alda, Martin; Adli, Mazda; Akula, Nirmala; Ardau, Raffaella; Bui, Elise T; Chillotti, Caterina; Cichon, Sven; Czerski, Piotr; Del Zompo, Maria; Detera-Wadleigh, Sevilla D; Grof, Paul; Gruber, Oliver; Hashimoto, Ryota; Hauser, Joanna; Hoban, Rebecca; Iwata, Nakao; Kassem, Layla; Kato, Tadafumi; Kittel-Schneider, Sarah; Kliwicki, Sebastian; Kelsoe, John R; Kusumi, Ichiro; Laje, Gonzalo; Leckband, Susan G; Manchia, Mirko; Macqueen, Glenda; Masui, Takuya; Ozaki, Norio; Perlis, Roy H; Pfennig, Andrea; Piccardi, Paola; Richardson, Sara; Rouleau, Guy; Reif, Andreas; Rybakowski, Janusz K; Sasse, Johanna; Schumacher, Johannes; Severino, Giovanni; Smoller, Jordan W; Squassina, Alessio; Turecki, Gustavo; Young, L Trevor; Yoshikawa, Takeo; Bauer, Michael; McMahon, Francis J

2010-01-01

385

Potential pros and cons of external healthcare performance evaluation systems: real-life perspectives on Iranian hospital evaluation and accreditation program  

PubMed Central

Background: Performance evaluation is essential to quality improvement in healthcare. The current study has identified the potential pros and cons of external healthcare evaluation programs, utilizing them subsequently to look into the merits of a similar case in a developing country. Methods: A mixed method study employing both qualitative and quantitative data collection and analysis techniques was adopted to achieve the study end. Subject Matter Experts (SMEs) and professionals were approached for two-stage process of data collection. Results: Potential advantages included greater attractiveness of high accreditation rank healthcare organizations to their customers/purchasers and boosted morale of their personnel. Downsides, as such, comprised the programs’ over-reliance on value judgment of surveyors, routinization and incurring undue cost on the organizations. In addition, the improved, standardized care processes as well as the judgmental nature of program survey were associated, as pros and cons, to the program investigated by the professionals. Conclusion: Besides rendering a tentative assessment of Iranian hospital evaluation program, the study provides those running external performance evaluations with a lens to scrutinize the virtues of their own evaluation systems through identifying the potential advantages and drawbacks of such programs. Moreover, the approach followed could be utilized for performance assessment of similar evaluation programs. PMID:25279381

Jaafaripooyan, Ebrahim

2014-01-01

386

Estudio de la fotoabsorción y fotoionización de la molécula de alta relevancia atmosférica no a través de los estados Rydberg con la metodología MQDO  

NASA Astrophysics Data System (ADS)

Los procesos de fotoionización son de una importancia fundamental [1] y encuentran aplicación en un gran número de contextos científicos: Astrofísica [2], química de las radiaciones, biología. Los investigadores de dichos campos, necesitan de valores de fiables de secciones eficaces para la fotoionización parcial, la Fotoabsorción, así como para los procesos de fotofragmentación en amplios intervalos espectrales, particularmente en estudios de modelización [3-5]. En este trabajo se ha centrado la atención sobre el oxido nítrico, que se ha considerado apropiado y relevante por varios motivos: por el trascendental papel que representa en la física y química de la alta atmosfera [6], aparte de por estar íntimamente relacionado con los problemas de contaminación. Los procesos de recombinación disociativa [7] del NO, donde los estados Rydberg se encuentran directamente implicados, son relevantes, por ejemplo, en las regiones E y F de la ionosfera [7]. En este trabajo se estudia la fotoionización del NO desde el estado fundamental con la versión molecular del método del orbital de defecto cuántico (MQDO). Para ello se calcula el diferencial de las fuerzas de oscilador parciales que constituyen los canales de fotoionización del NO desde el estado fundamental. La continuidad del diferencial de fuerza de oscilador calculada a través del umbral de fotoionización, esto es, en las regiones del espectro discreta y del continua, se adopta como criterio de calidad la escasez de datos comparativos [8].

Bustos, E.; Velasco, A. M.; Martín, I.; Lavín, C.

387

A wireless, remote-query and high sensitivity Escherichia coli O157: H7 biosensor based on the recognition action of Con A  

PubMed Central

Escherichia coli O157: H7 is detected using a remote-query (wireless, passive) magnetoelastic sensor platform to which a 1 µm-thick layer of Bayhydrol 110 and then a layer of functionalized mannose is applied. The multivalent binding of lectin concanavalin A (Con A) to the E. coli surface O-antigen and mannose favors the strong adhesion of E. coli to the mannose modified magnetoelastic sensor; E. coli is rigidly and strongly attached on the mannose-modified sensor through Con A, which works as a bridge to bind to the E. coli surface O-antigen and mannose modified sensor surface. As E. coli is bound to the sensor its resonance frequency shifts, enabling quantification of E. coli concentration with a limit of detection of 60 cells/mL and a linear logarithmic response range of 6.0×101 to 6.1×109 cells/mL. The analysis can be directly conducted without incubation, and completed in 3 h or less. PMID:19548666

Lu, Qingzhu; Lin, Hailan; Ge, Shutian; Luo, Shenglian; Cai, Qingyun; Grimes, Craig A.

2009-01-01

388

A Novel In Vivo siRNA Delivery System Specifically Targeting Liver Cells for Protection of ConA-Induced Fulminant Hepatitis  

PubMed Central

Background Fulminant hepatitis progresses to acute liver failure (ALF) when the extent of hepatocyte death exceeds the liver's regenerative capacity. Although small interfering RNA (siRNA) appears promising in animal models of hepatitis, the approach is limited by drawbacks associated with systemic administration of siRNA. The aim of this study is to develop a hepatocyte-specific delivery system of siRNA for treatment of fulminant hepatitis. Methodology/Principal Findings Galactose-conjugated liposome nano-particles (Gal-LipoNP) bearing siRNA was prepared, and the particle size and zeta potential of Gal-LipoNP/siRNA complexes were measured. The distribution, cytotoxicity and gene silence efficiency were studied in vivo in a concanavalin A (ConA)-induced hepatitis model. C57BL/6 mice were treated with Gal-LipoNP Fas siRNA by i.v. injection 72 h before ConA challenge, and hepatocyte injury was evaluated using serum alanine transferase (ALT) and aspartate transaminase (AST) levels, as well as liver histopathology and TUNEL-positive hepatocytes. The galactose-ligated liposomes were capable of encapsulating >96% siRNA and exhibited a higher stability than naked siRNA in plasma. Hepatocyte-specific targeting was confirmed by in vivo delivery experiment, in which the majority of Gal-LipoNP-siRNA evaded nuclease digestion and accumulated in the liver as soon as 6 h after administration. In vivo gene silencing was significant in the liver after treatment of Gal-Lipo-siRNA. In the ConA-induced hepatitis model, serum levels of ALT and AST were significantly reduced in mice treated with Gal-lipoNP-siRNA as compared with control mice. Additionally, tissue histopathology and apoptosis showed an overall reduction of injury in the Gal-LipoNP siRNA-treated mice. Conclusions/Significance This study is the first to our knowledge to demonstrate reduction of hepatic injury by liver-specific induction of RNA interference using Gal-LipoNP Fas siRNA, highlighting a novel RNAi-based therapeutic potential in many liver diseases. PMID:22970170

Jiang, Nan; Zhang, Xusheng; Zheng, Xiufen; Chen, Di; Siu, Kingsun; Wang, Hongmei; Ichim, Thomas E.; Quan, Douglas; McAlister, Vivian; Chen, Guihua; Min, Wei-Ping

2012-01-01

389

The soil-water balance simulations of a grassland in response to CO2, rainfall, and biodiversity manipulations at BioCON  

NASA Astrophysics Data System (ADS)

The BioCON (Biodiversity, CO2 and N) experiment has been continuously running since 1997. Operated by the University of Minnesota and located within the Cedar Creek Ecosystem Science Reserve in Minnesota, USA, BioCON is a Free-Air CO2 Enrichment (FACE) experiment that investigates plant community response to three key environmental variables: nitrogen, atmospheric CO2 and biodiversity. More recently rainfall exclusion and temperature manipulation were added to the experiment which amounts to 371 plots. The site attempts to replicate predicted average temperature increases and a northern shift of plant species and any associated consequences. FACE experiments have been conducted for a number of years in different countries, but the focus has generally been on how plant communities, soil respiration and microbes respond. Minimal work has been focused on the hydrologic aspects of these experiments which are potentially valuable for investigating global warming effects on local and plot-scale ecohydrology. Thus, the objective of this work is to characterize and model unsaturated flow for different CO2 and rainfall treatments in order to see how they affect soil moisture dynamics and groundwater recharge on grasslands of central Minnesota. Our study focuses on simulating soil moisture dynamics in eighteen of the BioCON plots: six bare plots with regular rainfall regimes (zero plant species, three plots with elevated atmospheric CO2 levels), six regular rainfall regimes (nine plant species, three plots with elevated atmospheric CO2 levels) and six reduced rainfall regimes (nine plant species, three plots with elevated atmospheric CO2 levels). The Simultaneous Heat and Water (SHAW) model, which solves the Richards equation for unsaturated zone water flow coupled to a comprehensive energy balance model, was parameterized with a combination of field and lab estimates of soil properties. Field estimates of saturated hydraulic conductivity using tension infiltrometers ranged from 9.8 x 10-4 to 6.7 x 10-3 cm/s. Soil cores were collected and analyzed for soil hydraulic properties (texture, unsaturated hydraulic conductivity and moisture retention). From the grain size analyzes of soil samples collected every 10 cm until 1m depth, the soil is homogenous and on average 87% sand, 11% silt and 2% clay. We will be presenting results from the simulations and statistical comparisons to observations of soil moisture at four depths in each plot.

Flinker, R. H.; Cardenas, M.; Caldwell, T. G.; Rich, R.; Reich, P.

2013-12-01

390

Intracellular free zinc up-regulates IFN-? and T-bet essential for Th1 differentiation in Con-A stimulated HUT-78 cells  

PubMed Central

Zinc deficiency impairs cellular immunity. Up-regulation of mRNA levels of IFN-?, IL-12R?2, and T-bet are essential for Th1 differentiation. We hypothesized that zinc increases Th1 differentiation via up-regulation of IFN-? and T-bet expression. To test this hypothesis, we used zinc-deficient and zinc-sufficient HUT-78 cells (a Th0 cell line) under different condition of stimulation in this study. We also used TPEN, a zinc-specific chelator, to decrease the bioavailability of zinc in the cells. We measured intracellular free zinc, cytokines, and the mRNAs of T-bet, IFN-?, and IL-12R?2. In this study, we show that in zinc-sufficient HUT-78 cells (a Th0 cell line), mRNA levels of IFN-?, IL-12R?2, and T-bet in PMA/PHA-stimulated cells were increased in comparison to zinc-deficient cells. Although intracellular free zinc was increased slightly in PMA/PHA-stimulated cells, Con-A-stimulated cells in 5 ?M zinc medium showed a greater sustained increase in intracellular free zinc in comparison to cells incubated in 1 ?M zinc. The cells pre-incubated with TPEN showed decreased mRNA levels of IFN-? and T-bet mRNAs in comparison to cells without TPEN incubation. We conclude that stimulation of cells by Con-A via TCR, release intracellular free zinc which functions as a signal molecule for generation of IFN-? and T-bet, and IL-12Rb?2 mRNAs required for Th1 cell differentiation. These results suggest that zinc increase Th1 cell differentiation by up-regulation of IFN-? and T-bet, and IL-12Rb?2 mRNAs. PMID:21439265

Bao, Bin; Prasad, Ananda S.; Beck, Frances WJ; Bao, Ginny W.; Singh, Tapinder; Ali, Shadan; Sarkar, Fazlul H.

2011-01-01

391

[Acute promyelocytic leukemias: clinico-biological aspects, prognostic factors, therapeutic response, and possibilities of cure in 34 cases (1970-1988)].  

PubMed

Thirty-four new cases of acute promyelocytic leukaemia (M3) were diagnosed at the authors' Centre between 1970 and 1988 (19 males and 15 females) with ages between 5 and 73 years (median age, 32 years). Three cases were of the hypogranular variant or M3-v (8.8%). The clinical picture included: haemorrhagic diathesis (85%), pallor/malaise (82%), fever/infection (41%), hepatomegaly (26%), splenomegaly (12%). Leucopenia of less than 5 x 10(9)/L was present in 23/34 cases, laboratory signs of DIC in 26/31, increased LDH, over 400 U/mL, in 6/31, and abnormal karyotype in 7/15. One of the patients rejected any treatment; two others died of brain haemorrhage before therapy was started, and seven died in the first two weeks of treatment. Of the 31 patients treated, complete remission (CR) was achieved in 21 cases (67.7%). Allogeneic BMT was carried out in two of them, with further relapse and death. Post-remission treatment was given to the remaining 19 patients, and there were 13 relapses. Six patients have been in CR, 5 of them after cessation of therapy, for the last 1.5-11.5 years. Age under 50 years and leucocyte count below 5 x 10(9)/L at diagnosis were favourable prognostic factors according to the univariate statistical analysis performed. The survival plateau of the actuarial curve was reached beyond 2.75 years by 15% of all the patients treated (33 cases), 23% of the patients who achieved CR (21 cases), 31% of the patients under 50 years of age and 5 x 10(9)/L leucocyte count at diagnosis (15 cases) and 36% of these last achieving CR (13 cases). PMID:2185563

Sánchez Fayos, J; Outeiriño, J; de Villalobos, E; Prieto, E; Bernacer, M; Calabuig, T; Benítez, J; Pérez Saenz, M A; Rodríguez, C; Paniagua, C

1990-02-01

392

A multi-centre clinico-genetic analysis of the VPS35 gene in Parkinson disease indicates reduced penetrance for disease-associated variants  

PubMed Central

Background Two recent studies identified a mutation (p.Asp620Asn) in the vacuolar protein sorting 35 gene as a cause for an autosomal dominant form of Parkinson disease . Although additional missense variants were described, their pathogenic role yet remains inconclusive. Methods and results We performed the largest multi-center study to ascertain the frequency and pathogenicity of the reported vacuolar protein sorting 35 gene variants in more than 15,000 individuals worldwide. p.Asp620Asn was detected in 5 familial and 2 sporadic PD cases and not in healthy controls, p.Leu774Met in 6 cases and 1 control, p.Gly51Ser in 3 cases and 2 controls. Overall analyses did not reveal any significant increased risk for p.Leu774Met and p.Gly51Ser in our cohort. Conclusions Our study apart from identifying the p.Asp620Asn variant in familial cases also identified it in idiopathic Parkinson disease cases, and thus provides genetic evidence for a role of p.Asp620Asn in Parkinson disease in different populations worldwide. PMID:23125461

Sharma, Manu; Ioannidis, John P A; Aasly, Jan O; Annesi, Grazia; Brice, Alexis; Bertram, Lars; Bozi, Maria; Barcikowska, Maria; Crosiers, David; Clarke, Carl E; Facheris, Maurizio F; Farrer, Matthew; Garraux, Gaetan; Gispert, Suzana; Auburger, Georg; Vilariño-Güell, Carles; Hadjigeorgiou, Georgios M; Hicks, Andrew A; Hattori, Nobutaka; Jeon, Beom S; Jamrozik, Zygmunt; Krygowska-Wajs, Anna; Lesage, Suzanne; Lill, Christina M; Lin, Juei-Jueng; Lynch, Timothy; Lichtner, Peter; Lang, Anthony E; Libioulle, Cecile; Murata, Miho; Mok, Vincent; Jasinska-Myga, Barbara; Mellick, George D; Morrison, Karen E; Meitnger, Thomas; Zimprich, Alexander; Opala, Grzegorz; Pramstaller, Peter P; Pichler, Irene; Park, Sung Sup; Quattrone, Aldo; Rogaeva, Ekaterina; Ross, Owen A.; Stefanis, Leonidas; Stockton, Joanne D; Satake, Wataru; Silburn, Peter A; Strom, Tim M; Theuns, Jessie; Tan, Eng- King; Toda, Tatsushi; Tomiyama, Hiroyuki; Uitti, Ryan J; Van Broeckhoven, Christine; Wirdefeldt, Karin; Wszolek, Zbigniew; Xiromerisiou, Georgia; Yomono, Harumi S; Yueh, Kuo-Chu; Zhao, Yi; Gasser, Thomas; Maraganore, Demetrius; Krüger, Rejko

2012-01-01

393

Clinico-Electroencephalography Pattern and Determinant of 2-year Seizure Control in Patients with Complex Partial Seizure Disorder in Kano, Northwestern Nigeria  

PubMed Central

Background: Complex partial seizures (CPS) may present with milder symptoms mimicking normal function of an adult person making the diagnosis delayed or often missed. There is a need for an in-depth training in epileptology to understand the various pattern of electro-clinical presentation of CPS. Ability to predict seizure control on first diagnosis can be very useful in the management of patients with CPS. However, there is a paucity of data on CPS in North-western Nigeria. Aim: This study aimed to describe the clinical and EEG characteristics of CPS and evaluate independent determinant of 2-year seizure control among adults with partial epilepsy in Kano, North-western Nigeria. Subjects and Methods: Out of all patients diagnosed with epilepsy (PWE) at the adult neurology clinic of two tertiary hospitals in Kano over a period of 4½ years, those with CPS were prospectively studied. Diagnosis of CPS was based on both clinical and EEG findings. Patients were followed-up for a minimum period of 2-year to determine their seizure control status. Data were analyzed using STATA version 10. Results: Total of 158 (105 males, 53 females) were enrolled. Their age ranged between 15 and 85 (median = 30.5) years. Sixty six (66/158,41.7%) had aura and 64 of them (64/158, 41.1%) had automatism. The most common aura and automatism were abnormal epigastric sensation and oro-alimentary respectively. Twenty eight (28/158, 18%) had associated behavioral manifestations. EEG abnormality was recorded in 56 (56/158, 53.9%). Adequate seizure control was achieved in 55% (70/128) on anti-epileptic drugs (AEDs). Duration of epilepsy, before the commencement of AEDs was identified as an independent determinant of 2-year seizure control. Conclusion: Abnormal epigastric sensation and oroalimentary automatism were the most common clinical complaint. Duration epilepsy over 3 years or less was identified as an independent predictor of 2-year seizure control. PMID:24761235

Owolabi, LF; Sale, S; Owolabi, SD

2014-01-01

394

Clinico-epidemiology of stings and envenoming of Hottentotta tamulus (Scorpiones: Buthidae), the Indian red scorpion from Jaffna Peninsula in northern Sri Lanka.  

PubMed

In recent years, stings of a lethal scorpion species were recorded from Jaffna Peninsula in the northern dry zone of Sri Lanka. This species was identified as Hottentotta tamulus (Scorpiones: Buthidae) which is the Indian red scorpion commonly found in Maharashtra, India. The Teaching Hospital, Jaffna recorded 84 H. tamulus stings over a year in 2012 and of them, 23 cases provided offending scorpions (proven cases). Three localities in Jaffna were recorded as hotspots of scorpion stings namely Palali, Achchuvali and Karainagar. Of the proven cases, 13 (57%) and 10 (43%) were males and females respectively and had a mean age of 30 years (SD ± 20 years). Among them, 5 (22%) were children below 12 years. In 13 (57%) patients stings occurred inside their houses including two children (40%). Six (26%) stings occurred at night when the victims were in sleep. Median time taken to arrive at the hospital from the time of stinging was 58 min (range 8-550 min). Signs of over activation of autonomic nervous system predominated the clinical picture-tachycardia in 14 (61%), high blood pressure in 11 (48%), excessive sweating in 9 (39%), excessive salivation in 5 (22%), hypotension in 4 (17%) and piloerection in 3 (13%). Children showed higher predilection to develop tachycardia - 4 (80%) and excessive salivation - 3 (60%). Priapism was not observed and 17 (74%) patients have developed intense pain at the site of sting. The commonest ECG change was tachycardia (73%) and occasional T wave inversion. Prazosin as a treatment was given to 22 (96%) patients. All patients made recovery and 13 (57%) patients left the hospital within two days. In future, there is a potential risk of spreading this species to elsewhere in the country and may disturb the ecological balance. PMID:25450799

Kularatne, Senanayake A M; Dinamithra, Nandana P; Sivansuthan, Sivapalan; Weerakoon, Kosala G A D; Thillaimpalam, Bhanu; Kalyanasundram, Vithiya; Ranawana, Kithsiri B

2015-01-01

395

[Clinico-epidemiological study of patients with phlebolymphatic diseases admitted to the hospitals of the Piedmont region 1976-1979. II. Analysis of lymphatic diseases and pulmonary embolism].  

PubMed

The second part of this research project looks at two very different pathologies. Pulmonary embolisms are usually emergency admissions, while lymphopathies, and this may well be an incorrect term, usually receive outpatient treatment and are only hospitalised in cases of serious incapacitation. Whereas lymphopathies were so few as to prevent any conclusions being drawn, regional admissions of pulmonary embolism occur every 28 hours and 44 minutes i.e. about 1 case per day. No particular relation between the distribution of pulmonary embolism and geographical area, level of industrialisation or migration was discovered. On the contrary there are few areas with higher figures than the expected regional average and these may be attributed to better medical organisation. Finally it should be emphasised that while cases of pulmonary embolism increase with age, the rise is less substantial than might have been expected. PMID:6856159

Raso, A M; Levis, P; Rispoli, P; Carlin, R

1983-06-16

396

A clinico-pathological conference on constrictive pericarditis secondary to rheumatoid arthritis: a case report with expert commentary and review of the literature.  

PubMed

Constrictive pericarditis is the commonest cardiac complication of rheumatoid arthritis (RA). Two percent of patients with RA develop significant clinical symptoms of pericarditis, which may not correlate with joint disease duration or severity. Symptoms are often vague and non-specific, which frequently delays the diagnosis and subsequent management. Surgical excision of the pericardium is the only definitive treatment option. We present the case of a 60 year-old lady with RA who presented with symptoms due to pericardial constriction and underwent radical pericardectomy. PMID:20851679

Jordan, Adam D; Khan, Muhammad E A; Hoey, Edward T; Rassl, Doris; Nashef, Samer A M

2011-01-01

397

Clinico-pathological characteristics of myeloid sarcoma at diagnosis and during follow-up: report of 12 cases from a single institution  

Microsoft Academic Search

The aim of this study was to describe the presenting features, the frequency and outcome of myeloid sarcoma (MS) diagnosed in our Institution from January 1995 to December 2000. Twelve MS were seen and the frequency account for only 2% of all acute myeloid leukemia (AML) patients observed in our department in the same period.Median age was 45 years (range:

Massimo Breccia; Franco Mandelli; Maria C. Petti; Mariella D’Andrea; Edoardo Pescarmona; Stefano A. Pileri; Ida Carmosino; Eleonora Russo; Paolo De Fabritiis; Giuliana Alimena

2004-01-01

398

Relationship between morphological features and kinetic patterns of enhancement of the dynamic breast magnetic resonance imaging and clinico-pathological and biological factors in invasive breast cancer  

PubMed Central

Background To investigate the relationship between the magnetic resonance imaging (MRI) features of breast cancer and its clinicopathological and biological factors. Methods Dynamic MRI parameters of 68 invasive breast carcinomas were investigated. We also analyzed microvessel density (MVD), estrogen and progesterone receptor status, and expression of p53, HER2, ki67, VEGFR-1 and 2. Results Homogeneous enhancement was significantly associated with smaller tumor size (T1: < 2 cm) (p = 0.015). Tumors with irregular or spiculated margins had a significantly higher MVD than tumors with smooth margins (p = 0.038). Tumors showing a maximum enhancement peak at two minutes, or longer, after injecting the contrast, had a significantly higher MVD count than those which reached this point sooner (p = 0.012). The percentage of tumors with vascular invasion or high mitotic index was significantly higher among those showing a low percentage (? 150%) of maximum enhancement before two minutes than among those ones showing a high percentage (>150%) of enhancement rate (p = 0.016 and p = 0.03, respectively). However, there was a significant and positive association between the mitotic index and the peak of maximum intensity (p = 0.036). Peritumor inflammation was significantly associated with washout curve type III (p = 0.042). Conclusions Variations in the early phase of dynamic MRI seem to be associated with parameters indicatives of tumor aggressiveness in breast cancer. PMID:20064215

2010-01-01

399

Short-Term Clinico-Radiographic Response to Super-Selective Intra-Arterial Cerebral Infusion of Bevacizumab for the Treatment of Vestibular Schwannomas in Neurofibromatosis Type 2  

PubMed Central

Summary Neurofibromatosis type 2 (NF2) is an autosomal dominant syndrome with a prevalence of approximately 1 in 30,000. NF 2 is characterized by bilateral vestibular schwannomas, as well as meningiomas, ependymomas and gliomas. Currently, surgical resection and radiotherapy represent the mainstay of treatment, although new studies suggest a role for certain chemotherapeutic agents. Intravenous administration of Bevacizumab (Avastin, Genetech Pharmaceuticals) has been shown to be active in the treatment of vestibular schwannomas. The IV route of administration, however, carries a risk of known systemic side-effects such as bowel perforation, wound dehiscence and pulmonary embolism. In addition, the percentage of drug that reaches the tumor site may be restricted by the blood tumor barrier. This report describes the super-selective intra-arterial infusion of Bevacizumab following blood brain barrier disruption for the treatment of vestibular schwannomas in three patients with Neurofibromatosis type 2. It represents the first time such a technique has been performed for this disease. Additionally, this method of drug delivery may have important implications in the treatment of patients with vestibular schwannomas associated with Neurofibromatosis type 2. PMID:22681725

Riina, H.A.; Burkhardt, J-K.; Santillan, A.; Bassani, L.; Patsalides, A.; Boockvar, J.A.

2012-01-01

400

Clinico-pathological features of tuberculosis due to Mycobacterium tuberculosis Uganda genotype in patients with tuberculous lymphadenitis: a cross sectional study  

PubMed Central

Background Tuberculous lymphadenitis is next to pulmonary tuberculosis as the most common cause of tuberculosis. Uganda genotype, one of the sub-lineages of Mycobacterium tuberculosis, is the most prevalent cause of pulmonary tuberculosis in Uganda. We here investigate the clinicopathological characteristics of patients with tuberculous lymphadenitis infected with M. tuberculosis Uganda genotype compared with those infected with M. tuberculosis non-Uganda genotype strains. Methods Between 2010 and 2012, we enrolled 121 patients (mean age 28.5 yrs, male 48%; female 52%) with tuberculous lymphadenitis, and categorized them by their M. tuberculosis genotypes. The clinical features and lymph node cytopathological parameters were compared between patients in the Uganda and non-Uganda categories using a crude and multivariable logistic regression model with adjustment for confounding factors. Results Of the 121participants, 56 (46%) were infected with strains of Uganda genotype. Patients infected with this genotype had significantly lower frequency of abdominal lymphadenopathy (odds ratio 0.4, p?=?0.046) after adjusting for sex, age and HIV. Abdominal lymphadenopathy was also significantly associated with abnormal chest X-ray (p?=?0.027). Conclusion Tuberculous lymphadenitis patients infected with M. tuberculosis Uganda genotype were significantly less prone to have abdominal lymphadenopathy indicating potential reduced ability to disseminate and supporting the concept that differences in M. tuberculosis genotype may have clinical implications. PMID:24690344

2014-01-01

401

ChIP Protocol for EZ-Magna ChIPTM A--anti-GFP, P19 cells *70% con)luent 6cm dish contains ~6.5 million P19 cells.  

E-print Network

. Resuspend the cell pellet with 500ul ice-cold PBS w/ 1X Protease inhibitor cocktail. Resuspend the pellet in 500ul of cell lysis buffer w/ 1X protease inhibitorChIP Protocol for EZ-Magna ChIPTM A--anti-GFP, P19 cells *70% con)luent 6cm

Oliver, Douglas L.

402

Collisions of matter-wave solitonsSupplementary Information for Collisions of matter-wave solitons Supplementary Figure 1: Comparison between the expansion of a soliton and a repulsive con-  

E-print Network

Collisions of matter-wave solitonsSupplementary Information for Collisions of matter-wave solitons Supplementary Figure 1: Comparison between the expansion of a soliton and a repulsive con- densate. a, the soliton propagates without dispersion, as expected. The small displacement in time is due to a slight time

Loss, Daniel

403

Liberación\\/mineralización de nitrógeno en hojarasca de Eucalyptus grandis y leguminosas herbáceas, su relación con la calidad física y química del residuo y su efecto sobre el crecimiento de plantas jóvenes de eucalipto  

Microsoft Academic Search

Resumen El tipo de cosecha y manejo de residuos inciden en el contenido de nutrientes del suelo y la productividad forestal. Estos residuos contienen la mayoría del retorno de N. La velocidad de provisión de nutrientes por la descomposición\\/mineralización puede verse afectada por la calidad química y física como por la localización y contacto de los residuos con el suelo.

Alcaraz Maria Luciana

404

PROYECTO SOSTAUGA: EL USO SOSTENIBLE DEL AGUA Y SU RELACIN CON EL TERRITORIO EN EL CAMPUS DE ELVIA Y DE LA ZAPATEIRA DE LA UNIVERSIDAD DE A CORUA_UDC  

E-print Network

aprovechamiento de las aguas residuales urbanas tanto en tiempo seco como de lluvia,1 PROYECTO SOSTAUGA: EL USO SOSTENIBLE DEL AGUA Y SU RELACIÃ?N CON EL TERRITORIO EN EL CAMPUS DE elemento agua y sus ecosistemas asociados. Preservar y potenciar un elemento clave del patrimonio socio

Fraguela, Basilio B.

405

IEEE TransacTIons on UlTrasonIcs, FErroElEcTrIcs, and FrEqUEncy conTrol, vol. 59, no. 1, JanUary 2012156 08853010/$25.00 2012 IEEE  

E-print Network

IEEE TransacTIons on UlTrasonIcs, FErroElEcTrIcs, and FrEqUEncy conTrol, vol. 59, no. 1, JanUary 2012156 0885­3010/$25.00 © 2012 IEEE Abstract--Piezoelectric devices, such as piezoelectric trav- eling-wave rotary ultrasonic motors, have composite piezoelec- tric structures. A composite piezoelectric structure

Pugh, Mary

406

ANALISI MATEMATICA con ELEMENTI di ALGEBRA XX ottobre 2013 1. A = {a, b, . . ., v, z} `e l'insieme delle 21 lettere dell'alfabeto italiano. Quante sono le parole di  

E-print Network

'insieme delle 21 lettere dell'alfabeto italiano. Quante sono le parole di 6 lettere, formate con lettere di A. A = {a, b, . . ., v, z} `e l'insieme delle 21 lettere dell'alfabeto italiano. Quante sono le parole di 6

Serapioni, Raul

407

IEEE TransacTIons on UlTrasonIcs, FErroElEcTrIcs, and FrEqUEncy conTrol, vol. 60, no. 7, JUly 20131386 08853010/$25.00 2013 IEEE  

E-print Network

IEEE TransacTIons on UlTrasonIcs, FErroElEcTrIcs, and FrEqUEncy conTrol, vol. 60, no. 7, JUly heterogeneous tumors. RF echo data spanning the 1 to 12 MHz frequency range were acquired in three dimensions. These functional signal-to-noise ratios indicated that BSC versus frequency variations between systems ranged from

Illinois at Urbana-Champaign, University of

408

08853010/$25.00 TBC IEEE 1IEEE TransaCTIons on UlTrasonICs, FErroElECTrICs, and FrEqUEnCy ConTrol, vol. TBC, no. TBC, TBC TBC  

E-print Network

0885­3010/$25.00 © TBC IEEE 1IEEE TransaCTIons on UlTrasonICs, FErroElECTrICs, and FrEqUEnCy Con, density, and spatial organization ranging from tightly clustered to nearly regular to mimic a broad range distribution models used in ultrason- ics literature. section IV describes the pool of synthetic Us data

Clark, James J.

409

IEEE TransacTIons on UlTrasonIcs, FErroElEcTrIcs, and FrEqUEncy conTrol, vol. 59, no. 9, sEpTEmbEr 20122066 08853010/$25.00 2012 IEEE  

E-print Network

IEEE TransacTIons on UlTrasonIcs, FErroElEcTrIcs, and FrEqUEncy conTrol, vol. 59, no. 9, s, and michael oelze, Senior Member, IEEE Abstract--Quantitative ultrasonic techniques using back- scatter on the inverse cubic of the size. Diameters of the distributions ranged between [25, 100], [25, 50], [50, 100

Illinois at Urbana-Champaign, University of

410

IEEE TransacTIons on UlTrasonIcs, FErroElEcTrIcs, and FrEqUEncy conTrol, vol. 59, no. 12, dEcEmbEr 2012 2655 08853010/$25.00 2012 IEEE  

E-print Network

IEEE TransacTIons on UlTrasonIcs, FErroElEcTrIcs, and FrEqUEncy conTrol, vol. 59, no. 12, dEcEmbEr 2012 2655 0885­3010/$25.00 © 2012 IEEE Transthoracic Cardiac Ultrasonic Stimulation Induces a Negative- diac bioeffects resulting from ultrasonic stimulation using a specific set of acoustical parameters

Illinois at Urbana-Champaign, University of

411

Diffusional homogenization of light REE in garnet from the Day Nui Con Voi Massif in N-Vietnam: Implications for SmNd geochronology and timing of metamorphism in  

E-print Network

Diffusional homogenization of light REE in garnet from the Day Nui Con Voi Massif in N Keywords: Sm­Nd Lu­Hf Garnet dating Trace elements Diffusion Vietnam High-grade migmatitic and mylonitic diffusional profiles in garnet. Laser ablation ICP-MS analyses of trace elements indicate that REE and Hf

Demouchy, Sylvie

412

08853010/$25.00 2009 IEEE 2145IEEE TransacTIons on UlTrasonIcs, FErroElEcTrIcs, and FrEqUEncy conTrol, vol. 56, no. 10, ocTobEr 2009  

E-print Network

EqUEncy conTrol, vol. 56, no. 10, ocTobEr 2009 Abstract--State-of-the-art 3-D medical ultrasound imaging requires transmitting and receiving ultrasound using a 2-D array of ultrasound transducers with hundreds and transducer array can lead to a portable, high-performance, and inexpensive 3-D ultrasound imaging system

Khuri-Yakub, Butrus T. "Pierre"

413

Wound Healing & Management Node: Titles list Version 1 1 July 2010 Publication list of Evidence Summary titles available in the Wound Healing and Management Node of the JBI COnNECT+ database as at 31 December 2011.  

E-print Network

Wound Healing & Management Node: Titles list Version 1 1 July 2010 Publication list of Evidence Summary titles available in the Wound Healing and Management Node of the JBI COnNECT+ database as at 31 December 2011. Authors: The Wound Healing and Management Node Group This list is updated quarterly Evidence

414

VENDERE IL LEGNO CON RESPONSABILITA'  

E-print Network

mass media, le istituzioni pubbliche e private, ...) Definizione di green marketing = un'evoluzione del: "pettenella" www.tesaf.unipd.it/pettenella/index.html 1. Introduzione Dal Total marketing al Social marketing iniziative del settore pubblico #12;2 Evoluzione del marketing Fino agli anni '30 il m. si concentra sui

Pettenella, Davide

415

CONVIVIENDO CON EL MEDIO AMBIENTE  

Microsoft Academic Search

El desarrollo a nivel industrial, agrícola y urbano genera acciones contaminantes cuyo efecto puede ser inmediato o a largo plazo (la lluvia ácida, los gases que provocan el efecto invernadero y que contribuyen al cambio climático, la explotación excesiva de los recursos naturales, o la deforestación de la selva tropical). Esto provoca la extinción de diferentes especies de plantas o

Cristina Ferrer Lacosta

2009-01-01

416

Quantum computing: pro and con  

Microsoft Academic Search

I assess the potential of quantum computation. Broad and important applications must be found to justify construction of a quantum computer; I review some of the known quantum algorithms and consider the prospects for nding new ones. Quantum computers are notoriously susceptible to making errors; I discuss recently developed fault-tolerant procedures that enable a quantum computer with noisy gates to

Charles C. Lauritsen

417

Quantum computing: pro and con  

Microsoft Academic Search

I assess the potential of quantum computation. Broad and important applications must be found to justify construction of a quantum computer; I review some of the known quantum algorithms and consider the prospects for finding new ones. Quantum computers are notoriously susceptible to making errors; I discuss recently developed fault-tolerant procedures that enable a quantum computer with noisy gates to

John Preskill

1998-01-01

418

De conformidad con la Ley de Derechos Humanos de 1977 del Distrito de Columbia, segn enmendada, Cdigo Oficial del Distrito de Columbia, Seccin 2-1401.01 et seq., (Ley), el Distrito de Columbia no discrimina, de forma visible ni percibida, por  

E-print Network

De conformidad con la Ley de Derechos Humanos de 1977 del Distrito de Columbia, según enmendada la ausencia, el empleado no perderá ninguno de sus beneficios de empleo, ni tampoco los derechos por las estipuladas por la Ley. LAS QUEJAS CON RESPECTO A ALGUNA DENEGACI�N DE LOS DERECHOS EN VIRTUD DE

Weaver, Harold A. "Hal"

419

Coagulase-negative staphylococci (CoNS) isolated from ready-to-eat food of animal origin--phenotypic and genotypic antibiotic resistance.  

PubMed

The aim of this work was to study the pheno- and genotypical antimicrobial resistance profile of coagulase negative staphylococci (CoNS) isolated from 146 ready-to-eat food of animal origin (cheeses, cured meats, sausages, smoked fishes). 58 strains were isolated, they were classified as Staphylococcus xylosus (n = 29), Staphylococcus epidermidis (n = 16); Staphylococcus lentus (n = 7); Staphylococcus saprophyticus (n = 4); Staphylococcus hyicus (n = 1) and Staphylococcus simulans (n = 1) by phenotypic and genotypic methods. Isolates were tested for resistance to erythromycin, clindamycin, gentamicin, cefoxitin, norfloxacin, ciprofloxacin, tetracycline, tigecycline, rifampicin, nitrofurantoin, linezolid, trimetoprim, sulphamethoxazole/trimethoprim, chloramphenicol, quinupristin/dalfopristin by the disk diffusion method. PCR was used for the detection of antibiotic resistance genes encoding: methicillin resistance--mecA; macrolide resistance--erm(A), erm(B), erm(C), mrs(A/B); efflux proteins tet(K) and tet(L) and ribosomal protection proteins tet(M). For all the tet(M)-positive isolates the presence of conjugative transposons of the Tn916-Tn1545 family was determined. Most of the isolates were resistant to cefoxitin (41.3%) followed by clindamycin (36.2%), tigecycline (24.1%), rifampicin (17.2%) and erythromycin (13.8%). 32.2% staphylococcal isolates were multidrug resistant (MDR). All methicillin resistant staphylococci harboured mecA gene. Isolates, phenotypic resistant to tetracycline, harboured at least one tetracycline resistance determinant on which tet(M) was most frequent. All of the isolates positive for tet(M) genes were positive for the Tn916-Tn1545 -like integrase family gene. In the erythromycin-resistant isolates, the macrolide resistance genes erm(C) or msr(A/B) were present. Although coagulase-negative staphylococci are not classical food poisoning bacteria, its presence in food could be of public health significance due to the possible spread of antibiotic resistance. PMID:25475289

Chaj?cka-Wierzchowska, Wioleta; Zadernowska, Anna; Nalepa, Beata; Sierpi?ska, Magda; ?aniewska-Trokenheim, ?ucja

2015-04-01

420

IEEE TransacTIons on UlTrasonIcs, FErroElEcTrIcs, and FrEqUEncy conTrol, vol. 60, no. 3, March 2013524 08853010/$25.00 2013 IEEE  

E-print Network

IEEE TransacTIons on UlTrasonIcs, FErroElEcTrIcs, and FrEqUEncy conTrol, vol. 60, no. 3, March ranges of 4 to 6 µm and 6 to 8 µm). The stiffness was found to lie between 4 and 22 mN/m and to decrease exponentially with the microbubble size within the diameter range investigated. No cantilever spring constant

Konofagou, Elisa E.

421

IEEE TransacTIons on UlTrasonIcs, FErroElEcTrIcs, and FrEqUEncy conTrol, vol. 60, no. 11, novEmbEr 2013 2257 08853010/$25.00 2013 IEEE  

E-print Network

IEEE TransacTIons on UlTrasonIcs, FErroElEcTrIcs, and FrEqUEncy conTrol, vol. 60, no. 11, nov) pulse length (PL), ranging here from 67 s to 6.7 ms, on the physi- ology of the FUS-induced BBB opening at different acoustic pressures, ranging from 0.30 to 0.60 MPa. Permeability and volume of opening were both

Konofagou, Elisa E.

422

Study on the Strategies for the Soil and Water Resource Con-servation of Slopeland in Taiwan in Response to the Extreme Climate  

NASA Astrophysics Data System (ADS)

Global climate change results in extreme weather, especially ex-treme precipitation in Taiwan. Though the total amount of precipi-tation remains unchanged, the frequency of rainfall return period increases which affects slopeland and causes sediment disaster. In Taiwan, slopeland occupies about 73% of national territory. Under harsh environmental stress, soil and water conservation of slope-land becomes more important. In response to the trends of global-ization impacts of climate change, long term strategic planning be-comes more necessary. This study reviewed international practices and decision making process about soil and water conservation of slopeland; and conducted the compilation and analysis of water and soil conservation related research projects in Taiwan within the past five years. It is necessary for Taiwan to design timely adaptive strategies about conducting the all-inclusive conservation of na-tional territory, management and business operation of watershed based on the existing regulation with the effects of extreme weather induced by climate change and the changes of social-economic en-vironments. In order to realize the policy vision of "Under the premise of multiple uses, operating the sustainable business and management of the water and soil resources in the watershed through territorial planning in response to the climate and so-cial-economic environment change". This study concluded the future tasks for soil and water con-servation: 1.Design and timely amend strategies for soil and wand water conservation in response to extreme weather. 2. Strengthen the planning and operating of the land management and integrated conservation of the water and soil resources of key watershed. 3. Manage and operate the prevention of debris flow disaster and large-scale landslide. 4. Formulate polices, related regulations and assessment indicators of soil and water conservation. 5. Maintain the biodiversity of the slopeland and reduce the ecological footprint. 6. Conduct soil and water conservation research according to the importance and urgency of policies. 7. Implement the international cooperation, technology communication, talent cultivation, and integrated education and promotion.

Huang, Wen-Cheng

2014-05-01

423

Revision curricular a partir de un analisis comparativo de las discrepancias en los curriculos de una escuela de optometria en Puerto Rico con las competencias requeridas para las agencias de revalida y acreditacion 2004  

NASA Astrophysics Data System (ADS)

El proposito de esta investigacion, un estudio cualitativo de caso, fue comparar y contrastar el curriculo vigente de la Escuela de Optometria de la UIAPR con las competencias y estandares requeridos por las agencias de acreditacion y de revalida. Con este proposito, decidimos realizar una revision y un analisis de documentos: el prontuario de cada uno de los cursos de los curriculos implantados en el 1993 y en el 2001; las competencias y estandares establecidos por las agencias de revalida y de acreditacion; y las estadisticas en las que se analiza el porcentaje de estudiantes que aprueban cada una de las partes de los examenes de revalida entre el 1998 al 2003. Se realizaron entrevistas dirigidas para dar apoyo y complementar la revision y el analisis de estos documentos. Los participantes de las entrevistas fueron tres estudiantes de la clase de optometria del 2004 (ultima clase del curriculo del 1993); tres estudiantes de la clase de optometria del 2005 (primera clase graduanda del curriculo vigente) y tres profesores y/o directores de los Departamentos de Ciencias Basicas, Ciencias Clinicas y Cuidado al Paciente. Esta investigacion se enmarco en el modelo de evaluacion curricular de discrepancia de Malcolm Provus y en el modelo de desarrollo basado en competencias. Uno de los hallazgos mas importantes del estudio es que los cambios que se implantaron al curriculo del 2001 no han logrado que los estudiantes mejoren su ejecucion en los examenes de revalida. Por otro lado, se encontro que el curriculo vigente atiende completamente los estandares de la practica de Optometria, pero no las competencias. Esta informacion fue validada mediante el uso de una tabla de cotejo para el analisis de los cursos y de la informacion obtenida de las entrevistas. El estudio determina y concluye que existen discrepancias entre los prontuarios de los cursos del curriculo y las competencias requeridas por la agencia de revalida. Segundo, que el Departamento de Ciencias Basicas es el que presenta mas deficiencias en el desarrollo de las competencias. El investigador recomienda disenar e implantar un curriculo basado en competencias y proveer formacion en didactica y procesos de aprendizaje a los profesores.

Rivera Pacheco, Andres

424

Millimeter-wave study of the CO-N 2 van der Waals complex: new measurements of CO- orthoN 2 and assignments of new states of CO- paraN 2  

NASA Astrophysics Data System (ADS)

Rotational transitions of the CO-N 2 van der Waals complex have been measured using the intracavity OROTRON jet spectrometer in the frequency range of 83-133 GHz. For the CO- orthoN 2 spin modification, the observed and assigned 21 rotational transitions belong to the Q- and P-branches of the K=1-0 subband. They complete the previous observation of the corresponding R-branch transitions. In the case of the less abundant form, CO- paraN 2, a new K=1 state, representing simultaneous rotation of both monomers, was detected for the first time. A total of 31 rotational transitions of CO- paraN 2 were assigned to two subbands connecting this new K=1 state with already known lower K=0 and 1 states. The assignments relied in part on energy level differences obtained from precise microwave data. The origin of the newly observed state was determined to be 3.41 cm -1 relative to the K=0 ground state of CO- paraN 2. The analysis yielded rotational parameters, centrifugal distortion parameters and nuclear quadrupole coupling constants due to the presence of two equivalent 14N nuclei for both CO- orthoN 2 and CO- paraN 2.

Surin, L. A.; Potapov, A. V.; Müller, H. S. P.; Panfilov, V. A.; Dumesh, B. S.; Giesen, T. F.; Schlemmer, S.

2006-08-01

425

The Big Con: China's Historical Sabotage  

ERIC Educational Resources Information Center

On June 4, 1989, the Chinese military, under orders from the highest levels of government, violently crushed peaceful civilian demonstrations in Beijing, most symbolically in and around Tiananmen Square. In the end, the Chinese government claimed that the death toll was approximately 200, but the Chinese Red Cross reported 2,000 to 3,000 deaths.…

Terrence Cheng

2009-01-01

426

Leiomioma uterino con extensión cardíaca: manejo anestésico  

Microsoft Academic Search

Summary A 61-year-old woman complaining of dyspnea with moderate effort was diagnosed with intravenous leiomyo- matosis arising in the inferior vena cava with right auri- cular extension. Surgery was performed in a one-stage procedure under extracorporeal circulation using atrio- tomy and venotomy of the inferior vena cava. Complete removal of the tumor was confirmed by transeso-phageal echocardiography during surgery. A

M. Jerez Anera; L. Delange Segura; J. Carmona Aurioles

427

Mjese las manos con agua tibia co-  

E-print Network

después de preparar alimentos Después de usar el baño o ayudar a un niño a usar el baño Después de manejar cada alimento y al cambiar de alimentos crudos a cocidos. Después de lavar, desinfecte los fre

428

Golden Rice - Evaluating the Pros and Cons  

NSDL National Science Digital Library

This activity engages students in evaluating the evidence and arguments related to Golden Rice and other possible strategies for preventing vitamin A deficiency. Students use this information to develop evidence-based conclusions about Golden Rice and the prevention of vitamin A deficiency. Students also develop questions that could provide important additional information for evaluating the arguments in favor of and opposed to Golden Rice and related policy proposals. In addition, students analyze how two reasonably accurate articles can present totally opposing points of view on this complex policy issue.

Waldron, Ingrid

429

Synthetic chemicals have been components of con-  

E-print Network

experi- mental animals are used1 and that products worth 5.6 trillion are regulated by such testing with the current approach to toxicology testing? An ideal study to under- stand whether an agent is harmful. The crucial question therefore is how useful are the cur- rent models, which are mostly animal models, and how

Cai, Long

430

Bilingual Education in Kyrgyzstan: Pros and Cons.  

ERIC Educational Resources Information Center

This paper discusses the potential of bilingual education and its possible implementation in Kyrgzystan, focusing on why bilingual education can be useful in solving linguistic tension in Kyrgzystan and which organizational questions must be considered to make bilingual education effective. The paper begins by examining and refuting common…

Korth, Britta

431

McLuhan: Pro and Con.  

ERIC Educational Resources Information Center

Twenty-one critical essays on the ideas and works of Marshall McLuhan are offered in this review. In the course of the essays, McLuhan is characterized alternately as a genius, an extrapolator, and an oracle; a defender of the choice of choicelessness; a generalizer who rearranges, misinterprets, and misreads the facts to support his theses; an…

Rosenthal, Raymond, Ed.

432

I-ConFIRM Steering Committee  

Cancer.gov

Skip to Main Content at the National Institutes of Health | www.cancer.gov Epidemiology and Genomics Research In NCI's Division of Cancer Control and Population Sciences Menu Search EGRP Site: EGRP Home About the Program Mission & Vision Organizational

433

Static Con dentiality Enforcement for Distributed Programs ?  

E-print Network

ucken, Germany, E-mail: mantel@dfki.de In Proceedings of the 9th Static Analysis Symposium, Madrid, Spain;dential data, but merely observing the presence of a mes- sage on a channel for encrypted traÃ?c may leak). These leaks might be intended (when planted by a Trojan-horse program) or unintended (when c

Sabelfeld, Andrei

434

Roofing with Urethane: Pro and Con.  

ERIC Educational Resources Information Center

Gerald Scott's favorable evaluation of the foamed polyurethane roofing system is based on experiences with 55 buildings at Texas A & M. Michael Kinzer, an architect at Colorado State University, disagrees and claims that the system is difficult to install and maintain, and the cost prohibitive. (MLF)

Kinzer, Michael; Scott, Gerald P.E.

1981-01-01

435

Endoscopist-Directed Propofol: Pros and Cons  

PubMed Central

Concerns about the safety of endoscopist-directed propofol (EDP) have been voiced that propofol should be given only by healthcare professionals trained in the administration of general anesthesia. Here we discuss the safety and drawbacks of EDP for routine endoscopic procedures. Currently, both diagnostic and therapeutic endoscopy are well tolerated and accepted by both patients and endoscopists due to the application of sedation in most clinics worldwide. Accordingly, propofol use is increasing in many countries. It is crucial for endoscopists to be very familiar with the use of propofol or a combination of drugs. However, the controversy regarding the administration of sedation by an endoscopist or an anesthesiologist continues. Until now, there have been no randomized control trials comparing sedation induced by propofol administered by an endoscopist or by an anesthesiologist. It might be difficult to perform this kind of study. For the convenience and safety of sedative endoscopy, it would be important that EDP be generally applied to endoscopic procedures, and for more safety, an anesthesiologist may automatically take care of particular patients at high risk of suffering from propofol side effects. PMID:24765594

Kim, Eun Hye

2014-01-01

436

Endoscopist-directed propofol: pros and cons.  

PubMed

Concerns about the safety of endoscopist-directed propofol (EDP) have been voiced that propofol should be given only by healthcare professionals trained in the administration of general anesthesia. Here we discuss the safety and drawbacks of EDP for routine endoscopic procedures. Currently, both diagnostic and therapeutic endoscopy are well tolerated and accepted by both patients and endoscopists due to the application of sedation in most clinics worldwide. Accordingly, propofol use is increasing in many countries. It is crucial for endoscopists to be very familiar with the use of propofol or a combination of drugs. However, the controversy regarding the administration of sedation by an endoscopist or an anesthesiologist continues. Until now, there have been no randomized control trials comparing sedation induced by propofol administered by an endoscopist or by an anesthesiologist. It might be difficult to perform this kind of study. For the convenience and safety of sedative endoscopy, it would be important that EDP be generally applied to endoscopic procedures, and for more safety, an anesthesiologist may automatically take care of particular patients at high risk of suffering from propofol side effects. PMID:24765594

Kim, Eun Hye; Lee, Sang Kil

2014-03-01

437

Communicating Genetic Risk: Pros, Cons, and Counsel  

Microsoft Academic Search

Shortly before his death in 1995, Kenneth B. Schwartz, a cancer patient at Massachusetts General Hospital (MGH), founded The Kenneth B. Schwartz Center at MGH. The Schwartz Center is a non-profit organization dedicated to supporting and advancing com- passionate health care delivery, which provides hope to the patient, support to caregivers, and encourages the healing process. The center sponsors the

RICHARD T. P ENSON; MICHAEL V. S EIDEN; KRISTEN M. SHANNON; MARCIE L. LUBRATOVICH; MARIA ROCHE; BRUCE A. CHABNER; THOMAS J. LYNCH; Schwartz Center Rounds

438

ORNL/CON-224 Energy Division  

E-print Network

.................................. 3 4. DESCRIPTION OF SUMMARY FORMAT ............................. 4 5. ELECTRIC VAPOR COMPRESSION ....................................... 114 6.1 Dynamic Vapor Compression Systems ....... ...................... 114 6.2 Chemical ............................................... 223 9. NOVEL HEAT PUMP CYCLES ............ ........................... 228 10. CROSSCUTTING PROJECTS

Oak Ridge National Laboratory

439

CON TITOLO DI STUDIO CONSEGUITO IN ITALIA  

E-print Network

ITALIANO O STUDENTE U.E. - titolo accademico: il conseguimento del titolo accademico in Italia può essere Consolato Italiano) su carta intestata completa di relativo timbro in originale; - traduzione ufficiale del Rappresentanza Italiana all'estero competente per territorio (Ambasciata Italiana o Consolato Italiano); - titolo

440

Incentives for organ donation: pros and cons.  

PubMed

Altruism still remains the main principle of organ donation worldwide. However, since the current practices has not met the demand for organs, new strategies should be found to encourage organ donation. Implementation of financial incentives in transplantation is a matter of debate among experts in the fields of transplantation, ethics, law, and economics. It should be acknowledged that donors incur many expenses while participating in the transplant process, which seems unfair. Various forms of incentives have been suggested and are currently used worldwide. This article describes current attitudes toward incentives for in transplantation used in different countries, arguing in favor as well as against them. PMID:22841275

Chkhotua, A

2012-01-01

441

¿Quién puede comunicarse con el CIS?  

Cancer.gov

El Servicio de Información sobre el Cáncer del NCI puede ayudarle si usted es un paciente o superviviente de cáncer, un familiar o un amigo preocupado, un proveedor de cuidados médicos o una persona que de algún modo ha sido afectada por el cáncer.

442

Economic Value Added: Pros and Cons  

Microsoft Academic Search

In times of uncertainty and crisis the performance measurement instruments should be reanalyzed. Thus, alongside the classic indicators of performance, in business financial analysis can be used modern indicators which offer a greater flexibility and efficiency. Such a measurement indicator for financial results closely correlated with the requirement of maximizing shareholder wealth is the Economic Value Added (EVA). The economic

Laura VASILESCU; Ana POPA

2011-01-01

443

The pros and cons of code validation  

NASA Technical Reports Server (NTRS)

Computational and wind tunnel error sources are examined and quantified using specific calculations of experimental data, and a substantial comparison of theoretical and experimental results, or a code validation, is discussed. Wind tunnel error sources considered include wall interference, sting effects, Reynolds number effects, flow quality and transition, and instrumentation such as strain gage balances, electronically scanned pressure systems, hot film gages, hot wire anemometers, and laser velocimeters. Computational error sources include math model equation sets, the solution algorithm, artificial viscosity/dissipation, boundary conditions, the uniqueness of solutions, grid resolution, turbulence modeling, and Reynolds number effects. It is concluded that, although improvements in theory are being made more quickly than in experiments, wind tunnel research has the advantage of the more realistic transition process of a right turbulence model in a free-transition test.

Bobbitt, Percy J.

1988-01-01

444

erators with general and specific information con-  

E-print Network

- able to support pathogenic microorganism growth or toxin formation, or garlic-in- oil mixtures Are Not Allowed? Fresh or dried meat or meat products includ- ing jerky Canned fruits, vegetables, vegetable butters, flavored oils, hummus, garlic dip, salsas etc. Fish or shellfish products Canned pickled products

Jawitz, James W.

445

erators with general and specific information con-  

E-print Network

pathogenic microorganism growth or toxin formation, or garlic-in- oil mixtures that are not modified in a way? Fresh or dried meat or meat products includ- ing jerky Canned fruits, vegetables, vegetable butters, flavored oils, hummus, garlic dip, salsas etc. Fish or shellfish products Canned pickled products

Jawitz, James W.

446

Vacuum assist: angel or demon CON.  

PubMed

Vacuum-assisted venous drainage (VAVD) to enhance venous return during cardiopulmonary bypass (CPB) was described as early as 1958 but was not widely used until the late 1990s. VAVD was initially used to facilitate the use of smaller cannulas with ministernotomy but was increasingly used to allow reduction in CPB circuit size while maintaining CPB flow rates. This innovation was made without planned consideration to CPB circuit design, most critically that of the venous reservoir. Clinical reports of prime reduction facilitated by VAVD in both adult and pediatric CPB were associated with reduced nadir hematocrit and rates of transfusion that encouraged the proliferation of VAVD in CPB. Concomitantly, investigators have reported both in vitro and in vivo significantly increased arterial emboli associated with the use of VAVD, mostly related to accelerated venous air entrainment. In vitro studies continue to confirm this association and likely underestimate the resulting embolic load as a result of flawed study design. While the evidence for VAVD is equivocal, our understanding of the clinical impact of gaseous microemboli in CPB is similarly limited, most likely confined to blood-brain barrier disruption. It is only after two decades that CPB component design is receiving serious attention in terms of air handling. The ethics of innovation in the field of CPB warrant careful consideration. The application of VAVD is not without consequence. PMID:23930383

Willcox, Timothy W

2013-06-01

447

The Pros and Cons of Cyberspying  

Microsoft Academic Search

The emergence of computers has only accelerated various transitions and added new directions to where the world is heading. Nowadays, such practices as e-commerce, e-government, and e-learning are commonplace. For many of us, it's almost impossible to imagine our lives without email. As the world evolves, we must embrace change and clearly understand the associated dangers. For instance, children have

Maria Ganzha

2005-01-01

448

B P C O,PATOLOGIA POLMONARE E SISTEMICA:E F F I C ACIA DOSE DIPENDENTE DELLA N-ACETILCISTEINA SULL' E VOLUZIONE DELLA MALAT T I A. Studio clinico controllato su una popolazione di sesso femminile  

Microsoft Academic Search

The Authors evaluated the efficacy of N-Acetyl cysteine (NAC) at a dosage of 1200 mg on re s p i r a t o ry functionality parameters, v i s c o s i m e t ry of the expectoration and systemic ox i d a t i ve carico versus NAC 600 mg, making re f e rence

Roberto Cogo; Alessandro Ramponi; Tiziano Motta

449

Investigaccion-accion en la sala de clases sobre las creencias de la cultura de la ciencia de un grupo de estudiantes universitarios y su relacion reciproca con el aprendizaje de las ciencias biologicas  

NASA Astrophysics Data System (ADS)

La investigacion---accion que se llevo a cabo en la sala de clases tenia como punto de partida las creencias de la cultura de la ciencia de un grupo de estudiantes universitarios para luego examinar sus implicaciones en el proceso de aprendizaje de las Ciencias Biologicas. ¿Que se supone que hagan las creencias en relacion con el aprendizaje? ¿En que consiste incorporar este aspecto a la practica educativa universitaria? Utilizando el modelo de Kemmis y McTaggart (1987) la investigacion-accion se planteo como un proceso dinamico en cuatro momentos en espiral constituidos por la planificacion, la accion, la observacion y la reflexion. Cada una de las fases tuvo una intencion retrospectiva y prospectiva formando una espiral de autorreflexion del conocimiento y la accion. Se llevaron a cabo audio grabaciones en clases y analisis de documentos. Ademas, la profesora-investigadora hizo un portafolio para reflexionar sobre las creencias de la cultura de la ciencia que tienen los estudiantes y las creencias del aprendizaje que tiene la profesora y sobre como la comprension de estos elementos ayudo a mejorar su practica educativa a traves del tiempo. Los resultados obtenidos apuntan a que las creencias de la cultura de la ciencia que tiene el grupo de estudiantes son diversas. Ellos si creen que la ciencia tiene una cultura la cual describieron como: complicada y desconocida que evoluciona constantemente, que es un conjunto de metodos, que es altamente tecnologica, que resuelve problemas de salud, ayuda a interpretar la realidad del mundo que los rodea y su origen y que existen unas intersecciones entre la ciencia y el poder. Sobre las creencias del proceso de aprendizaje de la profesora-investigadora, estas senalan que el modelaje de actores, la vision de la academia que tiene ella asi como la participacion y negociacion entre todos los involucrados en el proceso educativo, son factores que inciden en el proceso de aprendizaje.

Cordova-Santiago, Lizzette Astrid

450

The nature of the Ailao Shan-Red River (ASRR) shear zone: Constraints from structural, microstructural and fabric analyses of metamorphic rocks from the Diancang Shan, Ailao Shan and Day Nui Con Voi massifs  

NASA Astrophysics Data System (ADS)

The structural geology, timing of shearing, and tectonic implications of the ASRR shear zone, one of the most striking lineaments in Southeast Asia, have been the topics of extensive studies over the past few decades. The Xuelong Shan (XLS), Diancang Shan (DCS), Ailao Shan (ALS) and Day Nui Con Voi (DNCV) metamorphic massifs along the shear zone have preserved important information on its structural and tectonic evolution. Our field structural analysis, detailed microstructural and fabric analysis, as well as the quartz, sillimanite and garnet fabric studies of the sheared rocks from the massifs demonstrate the dominant roles of three deformation episodes during Cenozoic tectonic evolution in the shear zone. Among the contrasting structural and microstructural associations in the shear zone, D2 structures, which were formed at the brittle to ductile transition during large-scale left-lateral shearing in the second deformation episode, predominate over the structural styles of the other two deformation episodes. Discrete micro-shear zones with intensive grain size reduction compose the characteristic structural style of D2 deformation. In addition, several types of folds (early shearing folds, F21, and late-shearing folds, F22) were formed in the sheared rocks, including discrete to distributed mylonitic foliation, stretching lineation and shear fabrics (e.g., mica fish, domino structures, as well as sigma and delta fabrics). A sequence of microstructures from syn-kinematic magmatic flow, high-temperature solid-state deformation, to brittle-ductile shearing is well-preserved in the syn-kinematic leucocratic intrusions. Deformation structures from the first episode (D1) are characterized by F1 folds and distributed foliations (S1) in rocks due to pure shearing at high temperatures. They are preserved in weakly sheared (D2) rocks along the eastern margin of the ALS belt or in certain low-strain tectonic enclaves within the shear zone. Furthermore, semi-brittle deformation structures, such as hot striae and discrete retrogression zones, are attributed to normal-slip shearing in the third deformation episode (D3), which was probably locally active, along the eastern flank of the DCS range, for example. There are four quartz c-axis fabric patterns in the mylonitic rocks, including type A point maxima, type B Y point maxima with crossed girdles superimposition, type C quadrant maxima, as well as type D point and quadrant maxima combination. They are consistent with microscopic observations of microstructures of high-temperature pure shearing, low-temperature simple shearing and their superimposition. Integrated microstructural analysis and fabric thermometer studies provide information on both high temperature (up to 750 °C) and dominant low-temperature (300-600 °C) deformations of quartz grains in different rock types. Sillimanite and garnet fabrics, especially the latter, were primarily formed at the peak metamorphism during high-temperature pure shearing. The above structural, microstructural and fabric associations were generated in the tectonic framework of the Indian-Eurasian collision. The low-temperature microstructures and fabrics are attributed to left-lateral shearing along the ASRR shear zone from 27 to 21 Ma during the southeastward extrusion of the Indochina block, which postdated high-temperature deformation at the peak metamorphism during the collision.

Liu, Junlai; Tang, Yuan; Tran, My-Dung; Cao, Shuyun; Zhao, Li; Zhang, Zhaochong; Zhao, Zhidan; Chen, Wen

2012-03-01

451

Debate: Does genetic information in humans help us treat patients? PRO--genetic information in humans helps us treat patients. CON--genetic information does not help at all.  

PubMed

PRO: In the past decade, genotyping has started to help the neurologic practitioner treat patients with three types of epilepsy causing mutations, namely (1) SCN1A, a sodium channel gene mutated in Dravet's sporadic severe myoclonic epilepsy of infancy (SMEI and SMEB); (2) laforin (dual specificity protein phosphatase) and malin (ubiquitin E3 ligase) in Lafora progressive myoclonic epilepsy (PME); and (3) cystatin B in Unverricht-Lundborg type of PME. Laforin, malin, and cystatin B are non-ion channel gene mutations that cause PME. Genotyping ensures accurate diagnosis, helps treatment and genetic counseling, psychological and social help for patients and families, and directs families to organizations devoted to finding cures for specific epilepsy diseases. In SCN1A and cystatin B mutations, treatment with sodium channel blockers (phenytoin, carbamazepine, oxcarbazepine, lamotrigine) should be avoided. Because of early and correct diagnosis by genotyping of SCN1A mutations, the avoidance of sodium channel blockers, and aggressive treatment of prolonged convulsive status, there is hope that Dravet's syndrome may not be as severe as observed in all past reports. Genotyping also identifies nonsense mutations in Lafora PME. Nonsense mutations can be corrected by premature stop codon readthrough drugs such as gentamicin. The community practitioner together with epilepsy specialists in PME can work together and acquire gentamicin (Barton-Davis et al., 1999) for "compassionate use" in Lafora PME, a generalized lysosome multiorgan storage disorder that is invariably fatal. In Unverricht-Lundborg PME, new cohorts with genotyped cystatin B mutations have led to the chronic use of antioxidant N-acetylcysteine and combination valproate clobazam or clonazepam plus antimyoclonic drugs topiramate, zonisamide, piracetam, levetiracetam, or brivaracetam. These cohorts have minimal ataxia and no dementia, questioning whether the syndrome is truly progressive. In conclusion, not only is genotyping a prerequisite in the diagnosis of Dravet's syndrome and the progressive myoclonus epilepsies, but it also helps us choose the correct antiepileptic drugs to treat seizures in Dravet's syndrome and Unverricht-Lundborg PME. Genotyping also portends a brighter future, helping us to reassess the true course, severity, and progressive nature of Dravet's syndrome and Unverricht-Lundborg PME and helping us craft a future curative treatment for Dravet's syndrome and Lafora disease. Without the genotyping diagnosis of epilepsy causing mutations we are stuck with imprecise diagnosis and symptomatic treatment of seizures. CON: Genotyping of epilepsy may help to better understand the genetics of epilepsy, to establish an etiology in a patient with epilepsy, to provide genetic counseling, and to confirm a clinical diagnosis. However, critical analysis reveals that genotyping does not contribute to an improved treatment for the patients. In order to improve treatment, genotyping would have to (1) improve our ability to select the drug of choice for a given epilepsy or epileptic syndrome; (2) improve our ability to predict the individual risk of adverse reactions to certain drugs; (3) improve our ability to avoid unnecessary treatments or treatments that could aggravate seizures. Many example illustrate the lack of impact of genetic information on the treatment outcome: we do not treat Dravet syndrome more successfully since SCN1A testing became available; we do not treat Lafora disease more successfully since testing for laforin and malin became available; we do not need to know the genetic nature of Unverricht-Lundborg disease or test for the cystatin B mutation in order to select or avoid certain drugs; we do not treat Rett syndrome more successfully since MECP2 testing became available; we do not treat JME more successfully since we know its genetic origin; we do not treat autosomal dominant nocturnal frontal lobe epilepsy more successfully since we know its genetic origin and can test for its mutation. The clinical characteristics as well as the

Delgado-Escueta, Antonio V; Bourgeois, Blaise F D

2008-12-01

452

Science Drivers for Con-XScience Drivers for Con-X Presented by  

E-print Network

and their effect on galaxy formation Dark Matter and Dark Energy Use clusters of galaxies to trace the locations of Dark Matter and as independent probes to constrain the amount and evolution of Dark Energy Search for the missing baryonic matter in the Cosmic Web Cycles of Matter and Energy Study dynamics of Cosmic Feedback

Garcia, Michael

453

Adopte MiPlato: con los alimentos con protenas, la clave est en la variedad.  

E-print Network

, chicken anutty Spoo ey ow to creat ree Protein otein foods ach... Plate poste me tags (o is key fridge 8. Obtain food models or pictures of Protein Foods: fish, chicken, pork, beef, eggs, seeds, nuts, seeds, nuts and eggs Food models or pictures of Protein Foods: fish, chicken, pork, beef, eggs, seeds

454

Etude clinique et génétique de l’albinisme oculocutané : développement d’outils de diagnostic moléculaire et recherche de nouveaux gènes.  

E-print Network

??Notre travail s’est intéressé à l’albinisme oculocutané en étudiant ses aspects clinico- moléculaires. Malgré l’analyse approfondie des gènes connus d’albinisme oculocutané, 15 % des patients… (more)

Morice-Picard, Fanny

2013-01-01

455

[The forensic medical aspects of sudden cardiac death among the athletes].  

PubMed

The present review is focused on the main causes responsible for cardiac death among the athletes and the clinico-morphological characteristics of various forms of cardiac pathology leading to sudden death in the athletes. PMID:23272568

Khodasevich, L S; Kuzin, S G; Khodasevich, A L

2012-01-01

456

Eficacia del tratamiento antinflamatorio comparado con antibiótico y placebo en pacientes con bronquitis aguda no complicada y expectoración purulenta. Ensayo clínico aleatorio controlado con placebo.  

E-print Network

??Aquesta tesi tenia per objectiu conèixer l'eficàcia del tractament antiinflamatori (ibuprofèn 500 mg/8h/10d) o antibiòtic (amoxicil•lina+àcid clavulànic 500/125 mg/8h/10d) comparat amb placebo en la resolució… (more)

Bayona Faro, Carolina

2014-01-01

457

CADASIL: arteriopatía cerebral autonómica dominante con infartos subcorticales y leucoencefalopatía  

Microsoft Academic Search

CADASIL is a cerebrovascular autosomal dominant hereditary disease caused by a mutation of the Notch3 gene. Its principal clinical manifestations consist in migraine, recurrent cerebral ischemic episodes, dementia and neuropsychiatric disorders. It is characterized by accumulation of granular osmiophilic material (GOM) located in the middle layer of the small and median sized cerebral arteries. A clinical case is presented of

A. Palomeras i Vilches; A. Picas Jufresa; L. Ramió Torrentà; J. Cristóbal Buñuel Álvarez

2010-01-01

458

Clinical drawbacks of total lymphoid irradiation: the cons  

SciTech Connect

Success has been reported with use of total lymphoid irradiation (TLI) in organ transplant recipients and in patients with rheumatoid arthritis and other autoimmune diseases. In a well-conducted randomized double blind clinical trial, Cook et al have found that TLI was superior to sham irradiation of patients with multiple sclerosis (MS). However, it is clear from looking at this data that not all patients responded to TLI and that with time disease activity returned. Our own experience with TLI in two MS patients was very disappointing. Despite its apparent benefit in some conditions, considerable drawbacks are associated with TLI. These include high financial cost, unpleasant treatment-related side effects, and the possibility that more serious morbidity as well as mortality may be treatment-related. Furthermore, the optimum therapeutic regimen for TLI has not yet been established. Issues related to cumulative dose, dose per fraction, frequency of fractions, field of irradiation, and interaction with other therapies still need clarification. For these reasons we do not recommend TLI as a treatment for MS.

Myers, L.W.; Ellison, G.W.; Fahey, J.L.; Tesler, A.; Gottlieb, M.S.

1988-07-01

459

INEEL/CON-1999-343 October 1999  

E-print Network

between existing fusion experiment and fission test reactor availability. Present fusion experiments have a on Fusion Engineering Albuquerque, New Mexico October 25-28, 1999 #12;a. This work was prepared for the U. S. Department of Energy, Office of Fusion Energy Sciences, under the DOE Idaho Field Office contract number DE

California at Los Angeles, University of

460

RETENCION DE CROMO Y MERCURIO CON ZEOLITAS NATURALES Y SINTETICAS  

Microsoft Academic Search

La presencia de cationes de metales pesados en el agua crea problemas serios por sus efectos tóxicos sobre animales, plantas y sobre la salud humana. Como existe una gran variedad de procesos industriales que generan este tipo de contaminación, el control de la presencia de metales pesados en agua es difícil. Se ha usado, para algunos de ellos, técnicas de

Renán Arriagada; Rafael García; Ruby Cid

461

Montaje Experimental de Optica Adaptiva con Tecnología FPGA  

Microsoft Academic Search

An experimental platform based on FPGA devices, dedicated to implement active and adaptive optic software in HDL has been developed. The devel- oped assembly is the first of a series of works focused on this important area of instrumental astronomy. The exposed development is part of a Final Project of Electronic Engineering of the National University of Cordoba. FULL TEXT

F. Rodriguez Brizuela; J. P. Verasay; P. Recabarren

2010-01-01

462

Astrobiological Aspects of Mars and Human Presence: Pros and Cons  

PubMed Central

After the realization of the International Space Station, human exploratory missions to Moon or Mars, i.e. beyond low Earth orbit, are widely considered as the next logical step of peaceful cooperation in space on a global scale. Besides the human desire to extend the window of habitability, human exploratory missions are driven by several aspects of science, technology, culture and economy. Mars is currently considered as a major target in the search for life beyond the Earth. Understanding the history of water on Mars appears to be one of the clues to the puzzle on the probability of life on Mars. On Earth microorganisms have flourished for more than 3.5 Ga and have developed strategies to cope with so-called extreme conditions (e.g., hot vents, permafrost, subsurface regions, rocks or salt crystals). Therefore, in search for life on Mars, microorganisms are the most likely candidates for a putative biota on Mars and the search for morphological or chemical signatures of life or its relics is one of the primary and most exciting goals of Mars exploration. The presence of humans on the surface of Mars will substantially increase this research potential, e.g., by supporting deep subsurface drilling and by allowing intellectual collection and sophisticated in situ analysis of samples of astrobiological interest. On the other hand, such long-duration missions beyond LEO will add a new dimension to human space flight, concerning the distance of travel, the radiation environment, the gravity levels, the duration of the mission, and the level of confinement and isolation the crew will be exposed to. This will raise the significance of several health issues, above all radiation protection, gravity related effects as well as psychological issues. Furthermore, the import of internal and external microorganisms inevitably accompanying any human mission to Mars, or brought purposely to Mars as part of a bioregenerative life support system needs careful consideration with regard to planetary protection issues. Therefore, before planning any human exploratory mission, the critical issues concerning human health and wellbeing as well as protection of Mars in its pristine condition need to be investigated. PMID:19048093

Horneck, G

2008-01-01

463

Pros and cons of organ shielding for CT imaging.  

PubMed

With the increased importance of CT radiation dose to health care providers, patients and the general public, there is an increased responsibility to minimize patient dose effectively. Bismuth shields offer a simple strategy to reduce dose to certain anterior radiosensitive organs such as breasts and eyes. However, in order to reduce organ dose they must be used properly; improper use can lead to an actual increase in the patient dose. They also create a proportional increase in image noise in the section of the body adjacent to the shield and further reduce the quantitative precision of CT numbers. In addition, shielding can degrade the overall efficiency (by an order of approximately 10%) of the imaging process, reducing the theoretical image quality that can be expected from a certain level of patient dose. However, in spite of their significant disadvantages, there are certain clinical situations and practice considerations that provide qualified justification for their continued use. PMID:25304710

Samei, Ehsan

2014-10-01

464

ORNL/CON-460 The Evaluation of a 4000-Home  

E-print Network

..........................................................................................6 1.4.1 Data Collection 1.4.5 Analysis of Maintenance Costs ................................................................................................8 2. METHODOLOGY AND CALCULATION OF ENERGY SAVINGS.................................9 2.1 Field Data

Oak Ridge National Laboratory

465

Dial 3111 for Emergencies on Campus pecial emergency telephones con-  

E-print Network

Safety, with the assistance of the New Jersey College University Public Safety Association, has developed should provide: · The location of the call. · His or her identity. · The type of assistance needed alert, Public Safety will follow the U.S. Department of Homeland Security's procedures as necessary

466

The Prose of Blogging (and a Few Cons, Too)  

ERIC Educational Resources Information Center

"Blogging for the sake of blogging is fine, but what is the value added?" That's a question educational blogging advocates are now coming around to answer, and the value they're finding may seem preposterous to those who associate blogging with barely literate loudmouths and cyber predators. Can this often belligerent wasteland of poor punctuation…

Ramaswami, Rama

2008-01-01

467

Las personas con diabetes deben lograr un balance entre los  

E-print Network

en un lado del plato y los alimentos bajos en carbohidratos al otro lado. Karen Halderson, MPH, RD bajos en carbohidratos, manteniendo cada uno en su propio lado del plato o de la mesa. Comer vegetales en diferentes lados de su plato y ver si su plato está "balanceado". Sin embargo, muchas veces

468

El dramaturgo de Los olvidados: Entrevista con Juan Radrigán  

E-print Network

, "como el cielo, la piedad y los perros." Y quien mejor que él lo sabe. Radrigán es a los pobres lo que Egon Wolff, Vodanovic, Cuadra, son a la burguesía y clase media chilenas en la dramaturgia nacional. Todos ellos son fieles al medio que representan... actores deben aportar la caracterización. Ni siquiera maquillaje admite. En Hechos consumados hubo que hacer una excepción, pues una de las actrices era rubia y muy llamativa—para no decir hermosa—y debía desempeñar el papel de una vagabunda. Hubo que...

Bravo-Elizondo, Pedro

1983-10-01

469

Formal Veri cation of Con ict Detection Ricky Butler1  

E-print Network

Langley Research Center Hampton VA 23681-2199 munoz@icase.edu Abstract. Safety assessment of new air tra c , and Cesar Mu~noz3 1 Assessment Technology Branch, Mail Stop 130, NASA Langley Research Center Hampton, VA for aircraft separation is partially or completely moved from a centralized air tra c controller

Butler, Ricky W.

470

Pros and Cons of Paper and Electronic Surveys  

ERIC Educational Resources Information Center

This chapter describes the different types of paper and electronic surveys currently available and their costs and benefits in terms of equipment and printing costs, demands on staff time, and ease of use.

Porter, Stephen R.

2004-01-01

471

Learners or Participants? The Pros and Cons of "Lifelong Learning"  

ERIC Educational Resources Information Center

Whereas adult education used to be the preferred concept for those studying adult music-making, there is now an increasing trend away from this and towards lifelong learning. Uncritically adopting government lifelong learning discourses, however, blurs the line between educational ideals and political ones. Although there may be merit in the…

Mantie, Roger

2012-01-01

472

Pros and cons in the search for extraterrestrial intelligence  

Microsoft Academic Search

I propose a new term, ‘galactic organism with distinct intelligence’, for the extraterrestrial forms, with which humans can make contact. This is because, among the three existing terms: (a) ‘the search for extraterrestrial intelligence#x02019; ‘excludes biology and is inelegant#x02019; (b) ‘extraterrestrial#x02019; does not distinguish between the micro-organisms and highly-evolved intelligent life-forms; and (c) 'unidentified flying object' projects a sense of

S. Sri Kantha

1996-01-01

473

Astronomia solare e ottica con il foro stenopeico  

NASA Astrophysics Data System (ADS)

The observation of the Sun with pinholes was started in Florence's Cathedral in 1475, and in Ulugh Beg observatory in Samarcand in 1424-29, well before the invention of the telescope, for measuring the solar position and the variation of the obliquity of the Earth's axis. Later, with Kepler, pinholes' telescopes were used to follow the solar spots when the telescopes made by Galileo were not available. The use of pinholes in positional solar astrometry continued successfully up to 1800 in some great Italian and French Churches. Nowadays by using pinholes it is possible to show the principles of positional astronomy and imaging to students with instruments very easy to be built at almost no cost. The concepts of focal length, best focus, angular resolution, atmospheric seeing and atmospheric transmittance can be verified with such simple devices. Such pinhole telescopes have been built by primary-school students at the Astronomical Observatory dedicated to the Pope astronomer Sylvester II, located in Bukowiec, Poland, which is at its third year of activity. The largest solar spots have been observed clearly with these instruments, demonstrating the principles discussed in this presentation. The light cast by one of this devices with 70 m of focal length and 1 cm of diameter has permitted to repeat the experiences on the diffraction of the light, made in 1648 by the Jesuits Riccioli and Grimaldi.

Sigismondi, Costantino

474

University Facilities Planning & Con-Project Manager; Bahar Armaghani  

E-print Network

% recycled rubber tires Indoor Environmental Quality Carbon Dioxide monitoring Good housekeeping during conditions. Materials and Resources Building reuse, maintain 75% of existing shell Waste management plan

Slatton, Clint

475

Introduction The study attempts to quantify several con-  

E-print Network

was observed in the way that supervisors and hourly employees see the dominant cul- tures at the workplace- pany is related to the dominant climate in the workplace. A creative climate is characterized by high. Systems where open communication is the norm yield better outcomes and result in higher morale than more

476

Travellers' diarrhoea - pros and cons of different prophylactic measures.  

PubMed

Travellers' diarrhoea is the most likely cause for disturbing travel arrangements. At an average, 30-40% of tourists are concerned, depending on the travel destination. Due to the high impact on the travellers' health this topic is still of utmost importance in travel medicine. A wide spectrum of enteropathogens can be accountable, with enterotoxigenic Escherichia coli being the major causing pathogen among other bacteria, parasites and viruses. Here we discuss advantages and disadvantages of different prophylactic measures against travellers' diarrhoea. The effectiveness but also the relevance of hygiene education, vaccination and antibiotic or probiotic application will be discussed in the context of the travellers' different risk profiles. PMID:19915810

Wagner, Angelika; Wiedermann, Ursula

2009-10-01

477

Pro/con ethics debate: When is dead really dead?  

PubMed Central

Contemporary intensive care unit (ICU) medicine has complicated the issue of what constitutes death in a life support environment. Not only is the distinction between sapient life and prolongation of vital signs blurred but the concept of death itself has been made more complex. The demand for organs to facilitate transplantation promotes a strong incentive to define clinical death in a manner that most effectively supplies that demand. We consider the problem of defining death in the ICU as a function of viable organ availability for transplantation PMID:16356234

Whetstine, Leslie; Streat, Stephen; Darwin, Mike; Crippen, David

2005-01-01

478

Examinando algunas disyuntivas de política económica con un modelo estructural  

Microsoft Academic Search

En este documento se intenta dar respuesta, mediante el empleo de un modelo estructural, a tres tipos de interrogantes: las implicancias de una mejora en los procesos productivos, los efectos de un cambio en los niveles de endeudamiento público y los costos en términos del producto de un cambio en la tasa de inflación objetivo. Las simulaciones que arroja el

Luis Gonzalo Llosa Velásquez

2004-01-01

479

Experimentar con un cohete de plasma - Duration: 2:50.  

NASA Video Gallery

El Dr. Franklin Chang-Díaz, el primer astronauta hispano de la NASA, es actualmente el presidente y CEO de Ad Astra Rocket Company, la empresa que desarrolla el nuevo cohete de plasma VASIMR. Apren...

480

9 CFR 319.300 - Chili con carne.  

...Mechanically Separated (Species) may be used in accordance with § 319.6. Head meat, cheek meat, and heart meat exclusive of the heart cap may be used to the extent of 25 percent of the meat ingredients under specific declaration on the...

2014-01-01

481

9 CFR 319.301 - Chili con carne with beans.  

...Mechanically Separated (Species) may be used in accordance with § 319.6. Head meat, cheek meat, or heart meat exclusive of the heart cap may be used to the extent of 25 percent of the meat ingredients, and its presence shall be...

2014-01-01

482

9 CFR 319.300 - Chili con carne.  

Code of Federal Regulations, 2011 CFR

...Mechanically Separated (Species) may be used in accordance with § 319.6. Head meat, cheek meat, and heart meat exclusive of the heart cap may be used to the extent of 25 percent of the meat ingredients under specific declaration on the...

2011-01-01

483

Control de la congestión vehicular en Bogotá con herramientas microeconómicas  

Microsoft Academic Search

A partir de un diagnóstico de la congestión que las causas del problema van más allá de un exceso de vehículos y una falta de vías. Se estudian cuatro alternativas para reducir la congestión: la restricción de circulación por placas, el cobro por entrar en una zona de la ciudad, una política de parqueo y la creación de un nuevo

Arturo Ardila Gómez

1995-01-01

484

Encompassing Sexual Medicine within Psychiatry: Pros and Cons  

ERIC Educational Resources Information Center

Objective: This article examines the positive and negative aspects of psychiatry encompassing sexual medicine within its purview. Methods: MEDLINE searches for the period between 1980 to the present were performed with the terms "psychiatry," "sexual medicine," and "sexual dysfunction." In addition, sexual medicine texts were reviewed for chapters…

Segraves, Robert Taylor

2010-01-01

485

here's no end to the number of scams con-  

E-print Network

stress man- agement isn't about relaxation, better eat- ing, getting a massage, or practicing yoga. The best stress management strategy might be a better way to solve a stressful problem. Here's a problem-solving for- mula to apply to the root of a problem you face that causes stress: 1) Define the problem; 2

Kim, Duck O.

486

Strategic vision or strategic con?: Rhetoric or reality?  

PubMed

Major companies devote considerable effort to communicating corporate visions and missions. Yet three recent surveys suggest that much of this effort has been counter-productive. A gap has emerged between rhetoric and reality. Arenas of confrontation have arisen between directors and managers, head offices and business units, holding companies and their subsidiaries, and between specialists and generalists. A widespread desire for corporate transformation is not matched by understanding of how to bring it about. The lack of top management commitment and of communication skills are major barriers to change. More competent directors and more effective boards are needed. The article suggests key roles for the chairman and the chief executive. It examines how best to share a compelling vision, and identifies a requirement for new attitudes and approaches to communication. PMID:10118382

Coulson-Thomas, C

1992-02-01

487

Astrobiological aspects of Mars and human presence: pros and cons.  

PubMed

After the realization of the International Space Station, human exploratory missions to Moon or Mars, i.e. beyond low Earth orbit, are widely considered as the next logical step of peaceful cooperation in space on a global scale. Besides the human desire to extend the window of habitability, human exploratory missions are driven by several aspects of science, technology, culture and economy. Mars is currently considered as a major target in the search for life beyond the Earth. Understanding the history of water on Mars appears to be one of the clues to the puzzle on the probability of life on Mars. On Earth microorganisms have flourished for more than 3.5 Ga and have developed strategies to cope with so-called extreme conditions (e.g., hot vents, permafrost, subsurface regions, rocks or salt crystals). Therefore, in search for life on Mars, microorganisms are the most likely candidates for a putative biota on Mars and the search for morphological or chemical signatures of life or its relics is one of the primary and most exciting goals of Mars exploration. The presence of humans on the surface of Mars will substantially increase this research potential, e.g., by supporting deep subsurface drilling and by allowing intellectual collection and sophisticated in situ analysis of samples of astrobiological interest. On the other hand, such long-duration missions beyond LEO will add a new dimension to human space flight, concerning the distance of travel, the radiation environment, the gravity levels, the duration of the mission, and the level of confinement and isolation the crew will be exposed to. This will raise the significance of several health issues, above all radiation protection, gravity related effects as well as psychological issues. Furthermore, the import of internal and external microorganisms inevitably accompanying any human mission to Mars, or brought purposely to Mars as part of a bioregenerative life support system needs careful consideration with regard to planetary protection issues. Therefore, before planning any human exploratory mission, the critical issues concerning human health and wellbeing as well as protection of Mars in its pristine condition need to be investigated. PMID:19048093

Horneck, G

2008-08-01

488

The pros and cons of using irradiation for phytosanitary treatments  

Technology Transfer Automated Retrieval System (TEKTRAN)

Irradiation is increasingly being used as a phytosanitary treatment in Asia, Australia and the Americas, but the process is not being used or promoted in the European Union. However, under the current regulatory framework it is possible for food commodities irradiated to prevent the spread of alien...

489

iCons, 2011 Top 10 Scientific Achievements: Lesson Plan  

E-print Network

by negative (i.e. what's /not/ scientific). Example to help clarify might be Fire / Internal Combustion Engine.e. what's /not/ scientific). Example to help clarify might be Fire / Internal Combustion Engine

Auerbach, Scott M.

490

Modelli decisionali della dipendenza: simulazioni del In collaborazione con  

E-print Network

of addiction, delimited in Figure 1 by vertical dotted lines: controlled drug use, drug abuse, drug addiction, post-addiction stage. 3 #12;controlled use post-addiction stage drug addiction drug abuse Figure 1 of drug addiction is characterized by the condition of the preceding stage to which is added

Mocenni, Chiara

491

FILM E COPERTURE EDULI CON MATRICI A BASE DI FRUTTA  

Technology Transfer Automated Retrieval System (TEKTRAN)

Films based on pear puree were formed using thermal compression molding. Whey protein isolates and soy protein isolates were added to these films to improve their processing and strength. The effects of pear puree concentration, whey or soy protein concentration, moisture content and sorbitol cont...