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1

[Clinico-epidemiologic and clinico-nosologic characteristic of the hip trauma as a component of polysystemic damage].  

PubMed

Clinico-epidemiological and clinico-nosological indices of the hip injury (HI) in a structure of polysystemic and polyorgan damage, depending on gender, age of the injured patients, as well as the main mechanisms and conditions of trauma, were investigated. Four hundreds of charts of stationary patients, the injured persons, suffering polytrauma, who were treated in The Ternopyl University clinic in 2008 - 2012 yrs, were analyzed. The HI, as a component of polysystemic damage, was revealed in 54 patients. In accordance to the ranking analysis data, the HI coexistence in polytrauma probably depends on gender and age of the injured persons (mainly the men of employable age). Mostly such injures have occurred while the traffic accident in 61.1% of observations and while domestic conditions - in 29.6%. Severity of coexistent HI in a polytrauma structure probably depends on their mechanisms. So, in falling down in most cases combination with other skeletal trauma and damage of head was noted; in a direct punch - with cranio-cerebral trauma; in coexistence of various mechanisms the most severe injuries have occurred with damage of several anatomo-functional regions, not the hip only, but head, thorax and abdomen. PMID:25509438

Hur'iev, S O; Tsviakh, A I

2014-09-01

2

Pericoronal radiolucencies with significant pathology: Clinico-histopathologic evaluation.  

PubMed

Background: The purpose of the study was to correlate the provisional diagnosis of pericoronal radiolucencies associated with impacted, embedded, or unerupted teeth with the histopathologic diagnosis, and also to emphasize the importance of early detection for better diagnosis and management. Methods: This is a retrospective study involving 18 cases of pericoronal radiolucencies associated with unerupted, embedded, or impacted teeth whose data during 1-year period were retrieved, and were reviewed for clinical, radiological, and histopathologic data. Also, comparison and correlation of clinico-histopathologic diagnosis was made. Results: Of the 18 cases, 11 were provisionally diagnosed as dentigerous cyst and the remaining were diagnosed as ameloblastoma, odontogenic keratocyst, adenomatoid odontogenic tumor, and calcifying epithelial odontogenic cyst. Histopathologic diagnosis of the 18 cases showed varied results, with only 10% correlating with the provisional diagnosis. Conclusion: Although many pathological processes may present radiographically as pericoronal radiolucencies associated with unerupted teeth, the most common is the dentigerous cyst. Hence, it is crucial for the clinician to fully investigate all teeth that fail to erupt at the expected time, and promptly initiate appropriate assessment and management of suspected cystic lesions. PMID:25179716

Anand, Sanjeev; Kashyap, Bina; Kumar, Govind Raj; Shruthi, Basavaradhya Sahukar; Supriya, Alapati Naga

2014-09-01

3

Beyond cortical localization in clinico-anatomical correlation.  

PubMed

Last year was the 150th anniversary of Paul Broca's landmark case report on speech disorder that paved the way for subsequent studies of cortical localization of higher cognitive functions. However, many complex functions rely on the activity of distributed networks rather than single cortical areas. Hence, it is important to understand how brain regions are linked within large-scale networks and to map lesions onto connecting white matter tracts. To facilitate this network approach we provide a synopsis of classical neurological syndromes associated with frontal, parietal, occipital, temporal and limbic lesions. A review of tractography studies in a variety of neuropsychiatric disorders is also included. The synopsis is accompanied by a new atlas of the human white matter connections based on diffusion tensor tractography freely downloadable on http://www.natbrainlab.com. Clinicians can use the maps to accurately identify the tract affected by lesions visible on conventional CT or MRI. The atlas will also assist researchers to interpret their group analysis results. We hope that the synopsis and the atlas by allowing a precise localization of white matter lesions and associated symptoms will facilitate future work on the functional correlates of human neural networks as derived from the study of clinical populations. Our goal is to stimulate clinicians to develop a critical approach to clinico-anatomical correlative studies and broaden their view of clinical anatomy beyond the cortical surface in order to encompass the dysfunction related to connecting pathways. PMID:22995574

Catani, Marco; Dell'acqua, Flavio; Bizzi, Alberto; Forkel, Stephanie J; Williams, Steve C; Simmons, Andrew; Murphy, Declan G; Thiebaut de Schotten, Michel

2012-01-01

4

Accuracy of clinical diagnosis of idiopathic Parkinson's disease: a clinico-pathological study of 100 cases  

Microsoft Academic Search

Few detailed clinico-pathological correlations of Parkinson's disease have been published. The pathological findings in 100 patients diagnosed prospectively by a group of consultant neurologists as having idiopathic Parkinson's disease are reported. Seventy six had nigral Lewy bodies, and in all of these Lewy bodies were also found in the cerebral cortex. In 24 cases without Lewy bodies, diagnoses included progressive

A J Hughes; S E Daniel; L Kilford; A J Lees

1992-01-01

5

Towards integrated clinico-genomic models for personalized medicine: combining gene  

E-print Network

Towards integrated clinico-genomic models for personalized medicine: combining gene expression of Molecular Genetics and Microbiology, 2 Howard Hughes Medical Institute and 3 Department of Medicine, Duke Genomics Program, Institute for Genome Sciences and Policy, Duke University, Durham, NC 27708, USA Received

West, Mike

6

[Inflammatory pseudo-tumor of the lung. Clinico-pathologic report of a case].  

PubMed

One case of a solitary pulmonary nodule occurring in a 54-year-old woman with history of breast carcinoma is presented. Histological examination of the surgical specimen excluded breast carcinoma metastasis and revealed an inflammatory pseudotumor. Principal clinico-pathological findings in previously reported cases are described. Inflammatory pseudotumors may exhibit, as in our case, some nuclear atypia making the diagnosis sometimes difficult with malignancy. PMID:8489648

Bertheau, P; Arborio, M; Schill, H; Jancovici, R; Jeanbourquin, D; Pabot du Chatelard, P

1993-01-01

7

Clinico-etiological study of 30 erythroderma cases from tertiary center in South India  

PubMed Central

Background: Erythroderma is a morphological reaction pattern of skin having many underlying causes and finding the etiology helps in the proper management of erythroderma cases. Aim: To evaluate the clinical profile, etiology of erythroderma and to correlate clinical diagnosis with histopathology. Materials and Methods: This study was performed at the department of dermatology, Father Muller Medical College and Hospital, Mangalore, South India. We studied 30 consecutive cases of erythroderma with respect to the epidemiological, clinical and histological data. Clinico-histological correlation was analyzed for etiology of erythroderma. Results: The mean age of onset was 52.3 years with a male to female ratio of 14:1. In addition to erythroderma, other co-existent features included pruritus, fever, lymphadenopathy, and edema. Of the pre-existing dermatoses, psoriasis was the most common (33.3%) disease followed by eczema (20%), atopic dermatitis (6.6%), pityriasis rubra pilaris (3.3%) and drug-induced erythroderma (16.6%). In 16.6% of cases, etiology could not be ascertained. Clinico-histopathological correlation could be established in 73.3% of cases. Conclusion: Clinical features were identical irrespective of etiology. Detailed clinico-histopathological examination helps to establish the etiology of erythroderma. PMID:24616850

Hulmani, Manjunath; NandaKishore, B.; Bhat, M. Ramesh; Sukumar, D.; Martis, Jacintha; Kamath, Ganesh; Srinath, M. K.

2014-01-01

8

Intestinal congenital/infantile fibrosarcoma: a new clinico-pathological entity?  

PubMed

Congenital/infantile fibrosarcoma (IFS) is a relatively rare form of fibrosarcoma diagnosed at birth or during early years of life and that differs from its adult counterpart because of a more favorable behavior. IFS is also known as cellular congenital mesoblastic nephroma, when it affects the kidney and is often but not always characterized by the ETV6-NTRK3 fusion transcript. We report herein the first series of an exceptional tumor of the small intestine occurring in newborns. The four patients shared a stereotyped clinico-pathological presentation with early and acute onset, intestinal perforation, and an infiltration by a highly cellular spindle cell tumor within the dilated intestinal wall exhibiting pathologic features typical of IFS. Molecular studies for the ETV6-NTRK3 translocation were negative in the three cases tested. Patients were treated by surgical wide resection alone and are alive and well (follow-up: 36 months-25 years). Thus, this new clinico-pathological entity, even with lack of documented evidence of the ETV6-NTRK3 translocation, should be included in the differential diagnosis of congenital bowel perforation or obstruction and may represent an intestinal counterpart of IFS. PMID:25652760

Berrebi, Dominique; Fournet, Jean-Christophe; Boman, Françoise; Fabre, Monique; Philippe-Chomette, Pascale; Branchereau, Sophie; Fréneaux, Paul; Bouron-Dal Soglio, Dorothée; Michon, Jean; Peuchmaur, Michel

2015-04-01

9

Presenile dementia with motor neuron disease in Japan: clinico-pathological review of 26 cases.  

PubMed Central

The clinico-pathological findings of 26 cases of presenile dementia with motor neuron disease in Japan are reviewed. The characteristic features include: (1) Progressive dementia with slowly progressive onset in the presenile period. (2) Neurogenic muscular wasting during the course of illness. (3) A duration of illness to death of from one to three years. (4) Absence of extrapyramidal symptoms and definite sensory deficits. (5) No characteristic abnormalities in the CSF or EEG. (6) No known parental consanguinity of familial occurrence. (7) Non-specific mild degenerative changes throughout the CNS without evidence of cerebrovascular disease or primary degenerative dementia, but with the presence of pathological findings of motor neuron disease. The possibility that this is a new disease entity is suggested. Images PMID:6481390

Mitsuyama, Y

1984-01-01

10

[Clinico-economic aspects of physical rehabilitation of patients with coronary heart disease after endovascular interventions].  

PubMed

Physical rehabilitation is an important component of cardiorehabilitation and secondary prophylaxis programs for patients with coronary heart disease (CHD) especially after endovascular interventions. Of special importance among a variety of rehabilitative technologies under current conditions of financial crisis are those ensuring high-quality and cost-effective medical aid The clinico-economic analysis of the programs of long-term physical training is presented with reference to their application for rehabilitation of patients with CHD after endovascular intervention. The use of this approach on an individual basis is believed to promote the introduction of physical training methods into clinical practice, rational planning of secondary prophylaxis programs and reduction of financial burden on public health services. PMID:23718057

Liamina, N G; Razborova, I B; Kotel'nikova, E V; Karpova, É S; Nosenko, A N; Lipchanskaia, T P

2013-01-01

11

Clinico-Pathologic Relevance of Survivin Splice Variant Expression in Cancer  

PubMed Central

Survivin is a member of the inhibitor of apoptosis (IAP) family and has multifunctional properties that include aspects of proliferation, invasion and cell survival control. Survivin is a promising candidate for targeted cancer therapy as its expression is associated with poor clinical outcome, more aggressive clinico-pathologic features, and resistance to radiation and chemotherapy. In the present review the different properties of the Survivin splice variants are discussed and their activities correlated with different aspects of cancer cell biology, to include subcellular location. Special emphasis is placed on our current understanding of these Survivin splice variants influence on each other and on the phenotypic responses to therapy that they may control. PMID:23791888

de Necochea-Campion, Rosalia; Chen, Chien-Shing; Mirshahidi, Saied; Howard, Frank D.; Wall, Nathan R.

2013-01-01

12

Female Pattern Hair Loss: Clinico-Laboratory Findings and Trichoscopy Depending on Disease Severity  

PubMed Central

Background: Female pattern hair loss (FPHL) is a progressive hair loss disorder with unclear triggering and supporting factors. Trichoscopic features of each stage of FPHL have not been specifically elaborated previously. Aims: To analyze characteristics and investigate associations of clinico-laboratory and trichoscopic features of female patients in regard to the severity of hair loss in FPHL and to facilitate its diagnosis using noninvasive scalp dermoscopy (trichoscopy) in Fitzpatrick skin type III patients. Materials and Methods: Clinico-laboratory and trichoscopic data from 60 patients with FPHL were analyzed using Spearman's correlation test. Results: Patients had mean age of 34.4±10.6 years and mean duration of hair loss of 4.49±3.76 years. Of all, 45% (27/60) had a family history of pattern hair loss (PHL) and had an earlier onset of hair loss. Stage of hair loss positively correlated with duration and age at presentation. No association was found between the severity of FPHL and laboratory values including anemic and gonadal hormone profiles. Characteristic trichoscopic features (at 10-fold magnification) of FPHL were peripilar signs (PPS) (brown, BPPS and white, WPPS), white dots, scalp pigmentation, and focal atrichia. WPPS, scalp pigmentation, and focal atrichia positively correlated with the stage and duration of hair loss. Conclusions: Family history of PHL causes an earlier onset of hair loss but does not influence its course or severity. The latter is also not affected by abnormal anemic profile or hormonal levels. PPS, scalp pigmentation, focal atrichia, and white dots are characteristic of PHL. WPPS, scalp pigmentation, and focal atrichia reflect advanced PHL. PMID:22628986

Zhang, Xingqi; Caulloo, Sillani; Zhao, Ying; Zhang, Bin; Cai, Zeming; Yang, Jian

2012-01-01

13

[Clinico-economical efficacy of angiotensin converting enzyme inhibitors in patients with arterial hypertension and ischemic heart disease].  

PubMed

We conducted comparative analysis of clinico-economical efficacy of angiotensin converting enzyme inhibitors as components of combination therapy of patients with arterial hypertension and ischemic heart disease. Clinical efficacy of fosinopril, moexipril, perindopril, and ramipril was comparable: in compared groups statistically significant lowering of arterial pressure was achieved by day 6 of treatment and this lowering persisted up to day 36 of therapy with ramipril. All studied drugs were well tolerated. Ramipril was notable for highest economical efficacy determined by the method of \\"minimization of expenditures\\". Technology of assessment of clinico-economical effectiveness of preparations from the same pharmacological group can be used in compilation of standards of drug therapy of various diseases, basing on which a physician administers a concrete drug to a concrete patient. PMID:18729835

Korennova, O Iu; Petrenko, A V; Petrenko, M A; Kurt-Kovalenko, E V; Turusheva, E A; Alekseeva, S V; Mashinskaia, L G; Shupina, M I; Osipova, E A

2008-01-01

14

Clinico-pathomorphological, serum biochemical and histological studies in broilers fed ochratoxin A and a toxin deactivator (Mycofix® Plus)  

Microsoft Academic Search

1.?Toxic effects of two concentrations (0·5 and 1 mg\\/kg) of ochratoxin A (OTA) and attenuating effects of a toxin deactivator (Mycofix® Plus) containing the yeast Trichosporon mycotoxinivorans on the performance (feed conversion ratio; body weight gain), serum enzymes (lactate dehydrogenase, gamma-glutamyltranspeptidase and aspartate aminotransferase) and clinico-pathomorphology of internal organs were studied in 270 one-day-old broiler chicks divided into 9 groups over

N. Q. Hanif; G. Muhammad; M. Siddique; A. Khanum; T. Ahmed; J. A. Gadahai; G. Kaukab

2008-01-01

15

The clinico-pathology and mechanisms of trypanosomosis in captive and free-living wild animals: A review  

Microsoft Academic Search

Reports on the clinico-pathology and mechanisms of trypanosomosis in free-living and captive wild animals showed that clinical\\u000a disease and outbreaks occur more commonly among captive than free-living wild animals. This is because the free-living wild\\u000a animals co-exist with the disease until subjected to captivity. In exceptional cases however, draught, starvation and intercurrent\\u000a diseases often compromised trypanotolerance leading to overt trypanosomosis

A. W. Mbaya; M. M. Aliyu; U. I. Ibrahim

2009-01-01

16

Application of Clinico-Radiologic-Pathologic Diagnosis of Diffuse Parenchymal Lung Diseases in Children in China  

PubMed Central

Diffuse parenchymal lung diseases in children (chDPLD) or interstitial lung diseases in children (chILD) represent a heterogeneous group of respiratory disorders that are mostly chronic and associated with high morbidity and mortality. However, the incidence of chDPLD is so low that most pediatricians lack sufficient knowledge of chDPLD, especially in China. Based on the clinico- radiologic- pathologic (CRP) diagnosis, we tried to describe (1) the characteristics of chDPLD and (2) the ratio of each constituent of chDPLD in China. Data were evaluated, including clinical, radiographic, and pathologic results from lung biopsies. We collected 25 cases of chDPLD, 18 boys and 7 girls with a median age of 6.0 years, from 16 hospitals in China. The most common manifestations included cough (n = 24), dyspnea (n = 21), and fever (n = 4). There were three cases of exposure-related interstitial lung disease (ILD), three cases of systemic disease-associated ILD, nineteen cases of alveolar structure disorder-associated ILD, and no cases of ILD specific to infancy. Non-specific interstitial pneumonia (n = 9) was the two largest groups. Conclusion: Non-specific interstitial pneumonia is the main categories of chDPLD in China. Lung biopsy is always a crucial step in the final diagnosis. However, clinical and imaging studies should be carefully evaluated for their value in indicating a specific chDPLD. PMID:25569558

Xu, Dan; Chen, Zhimin; Chen, Huizhong; Huang, Rongyan; Zhao, Shunying; Liu, Xiuyun; Zhou, Chunju; Peng, Yun; Yuan, Xinyu; Zou, Jizhen; Zhang, Hailing; Zhao, Deyu; Liu, Enmei; Zheng, Yuejie; Zhong, Lili; Lu, Min; Lu, Jirong; Nong, Guangmin

2015-01-01

17

Clinico-pathological characteristics of different types of immunodeficiency-associated smooth muscle tumours.  

PubMed

Rare Epstein-Barr virus (EBV)+ smooth muscle tumours (SMT) manifest typically under immunosuppression. Three major subtypes are known: human immunodeficiency virus-associated (HIV-SMT), after transplantation (PTSMT) or associated with congenital immunodeficiency syndromes (CI-SMT). So far, there are no analyses which compare the clinico-pathological characteristics of all three subtypes. Case reports and case series on these three tumour types were collected (1990-2012). Meta-data analysis was performed for identification of similarities and differences. A total of 73 HIV-SMT, 66 PTSMT and 9 CI-SMT were evaluated. There was a slight female predominance (55-67%). Children were affected nearly equally in HIV-SMT (33%) and PTSMT (35%), while all CI-SMT occurred in children. HIV-SMT manifested preferentially in the central nervous system, gut/liver, skin, lungs/larynx/pharynx and adrenal glands. PTSMT were predominantly found in the liver, lungs/larynx/pharynx, gut/spleen and brain. CI-SMT were often found in lungs/larynx, brain, liver, adrenal glands and spleen. Antecedent EBV+ lymphoproliferations manifested more often in PTSMT. In all three tumour subtypes, survival analyses did not show any significant differences regarding surgical therapeutic approaches, the occurrence of multiple tumours, tumour size or sarcoma-like histological features. HIV-SMT had the poorest overall survival, which might be attributed to HIV-associated infectious complications. PMID:25027306

Hussein, Kais; Rath, Berenice; Ludewig, Britta; Kreipe, Hans; Jonigk, Danny

2014-09-01

18

Impact of clinico-radiological parameters on the outcome of treatment in brain tuberculosis  

PubMed Central

Objectives: The Aim of this study was to evaluate the impact of clinico-radiological parameters on the outcome of the treatment in brain tuberculosis. Materials and Methods: This study was conducted in the Department of Neurosurgery and Neurology Skims Srinagar India for a period of two years from November 2009 to November 2011. A total of 61 patients presenting with brain tuberculosis admitted at skims during these two years were included in the study. Patients having clinical, laboratory and radiological findings suggestive of brain tuberculosis were included in the study. On correlating the CT characteristics-tuberculomas, basal exudates and hydrocephalus with sequelae at 6,12 and 18 months - focal deficit, cognitive impairment, and diplopia. Results: It was seen that basal exudates correlated with all the three neurological sequelae i.e.; with focal deficit (P = 0.001), cognitive impairment (P = 0.011), and diplopia (P = 0.021). Hydrocephalus correlated well with cognitive impairment (P = 0.031) and tuberculoma correlated with none of these clinical characteristics. Conclusion: We concluded that the mortality and neurologic sequelae were directly related to the clinical stage of disease at presentation. Correlating the CT characteristics we concluded that basal exudates correlated with all the three sequelae i.e.; with focal deficit, cognitive impairment, and diplopia. Hydrocephalous correlated well with cognitive impairment and tuberculoma correlated with none of these clinical characteristics. PMID:25126120

Lone, Manzoor Ahmad; Ganie, Farooq Ahmad; Ramzan, Altaf Umar; Kelam, Mohd Arif; Khan, Abdul Quoom; Masratul-Gani

2014-01-01

19

Human Cystic Echinococcosis in the Nalut District of Western Libya: A Clinico-epidemiological Study  

PubMed Central

Human cystic echinococcosis (CE) is an endemic disease in the Mediterranean area that has not yet been fully documented in western Libya. The present study describes the clinico-epidemiologic profile of CE in western Libya’s Nalut district. From April 2008 to July 2011, 36 cases of CE were confirmed following surgical removal of cysts. The cysts were most frequently found in the liver (61.1%), followed by the lungs (19.4%), kidneys (11.1%), peritoneal cavity (11.1%), and spleen (5.6%). Among the 36 patients, 6 possessed plural cysts and 3 had cysts in 2 organs. Blood samples from this group were examined for the presence of serum anti-hydatid IgG antibodies, which revealed positivity in 25 patients (69.4%). An additional 300 blood samples were collected randomly from the inpatient and outpatient clinics at Nalut Hospital. Twenty-seven samples (9%) were found to be positive for the anti-hydatid IgG antibody among which the prevalence of infection tended to be higher in men (12%) than in women (6%). This study demonstrates that CE is a major parasitic infectious disease of public health significance in Libya, notably in the western part of the country, and that disease awareness needs to be raised nationwide. PMID:25589882

Mohamed, Rabie M.; Abdel-Hafeez, Ekhlas H.; Belal, Usama S.; Norose, Kazumi; Aosai, Fumie

2014-01-01

20

Clinico-epidemiological and Socio-behavioral Study of People Living with HIV/AIDS  

PubMed Central

Although India is in the grip of HIV/AIDS epidemic, not much information is available on clinico-epidemiological and socio-behavioral aspects of people living with HIV/AIDS (PLWHA). This study analyzed these features using standard methodologies in 82 HIV sero-positives, AIDS patients attending ART clinic of three major government hospitals of Delhi. Majority of the patients (73%) were found to be young (<40 years) and married (79%). As high as 91.5% came from low socio-economic class and more than 95% acquired HIV transmission through heterosexual routes. A large proportion (63%) of these patients reported an extremely high level of anxiety, moderate level of stress and a borderline level of clinical depression. While most of the patients (72%) were well-adjusted with the ART, the rest of the patients reported difference in making adjustment with the treatment schedules. The study suggests that counseling and supportive therapy could play a pivotal role in controlling anxiety, stress, depression and rehabilitating people with HIV/AIDS. PMID:21799555

Khan, M. A.; Sehgal, A.

2010-01-01

21

Blastic plasmacytoid dendritic cell neoplasms: clinico-immunohistochemical correlations in a series of 91 patients.  

PubMed

Blastic plasmacytoid dendritic cell neoplasm is a rare clinicopathologic entity, characterized by strong skin tropism and a poor prognosis. The diagnosis is generally made by skin biopsy with appropriate immunohistochemical studies. To identify potential biological prognostic factors for blastic plasmacytoid dendritic cell neoplasm, we performed an extended clinico-immunohistochemical study on a series of 91 well-documented cases collected since 1995 by the French Study Group on Cutaneous Lymphomas. Skin biopsies were analyzed using a panel of 12 immunohistochemical markers (CD4, CD56, CD123, CD303, TCL1, CD68, CD2, CD7, TdT, Ki-67, S100, and MX-1). The results were correlated with survival. The 5 most characteristic markers of this entity (CD4, CD56, CD123, CD303, and TCL1) were expressed simultaneously in only 46% of patients. However, when 4 markers were expressed the diagnosis could still be reliably made without resorting to any additional stains. Expression of TdT and/or S100 correlated with varying degrees of maturation. Statistical survival analyses showed that CD303 expression and high proliferative index (Ki-67) were significantly associated with longer survival. PMID:24441662

Julia, Fanny; Dalle, Stephane; Duru, Gerard; Balme, Brigitte; Vergier, Béatrice; Ortonne, Nicolas; Vignon-Pennamen, Marie D; Costes-Martineau, Valérie; Lamant, Laurence; Dalac, Sophie; Delattre, Claire; Déchelotte, Pierre; Courville, Philippe; Carlotti, Agnès; De Muret, Anne; Fraitag, Sylvie; Levy, Annie; Mitchell, Andrew; Petrella, Tony

2014-05-01

22

[A case of adult onset subacute sclerosing panencephalitis; sequential clinico-radiological findings over two years].  

PubMed

We present a very rare case of adult onset subacute sclerosing panencephalitis (SSPE), and explain the characteristic sequential clinico-radiological findings. The patient, a twenty three-year-old man, had noticed unsteadiness in walking about two months previously. Although inosine pranobex and intrathecal interferon were administered, symptoms worsened insidiously and he became bedridden after four months. The levels of serum and CSF anti-measles IgG antibodies have not changed. Initially, supratentorial cortical atrophy was observed, especially of the left temporal lobe, but there were no other MRI signal alterations at the time. After three months, the supratentorial cortices produced low-signal intensities in T1-weighted images and in T2-weighted MRI, the cortical margin was very unclear and white matter signal intensities had become higher. Furthermore, cortices became thinner and ventricular size increased, especially for the lateral and third ventricles. SPECT examinations showed a marked reduction in cerebral blood flow and the perfusion deficits observed seemed to be closely correlated with the abnormal MRI signal patterns. Pathological examinations of biopsy samples revealed infiltration of inflammatory cells around the small vessels. As for immunohistochemical findings, CD68 positive cells were frequently observed, and this result implied the activation of microglia. Further studies are necessary to elucidate the pathogenic mechanisms of SSPE. PMID:16248401

Tajima, Yasutaka; Sudoh, Kazumasa; Matsumoto, Akihisa

2005-09-01

23

Clinico-biological characteristics and treatment of type I monoclonal cryoglobulinaemia: a study of 64 cases.  

PubMed

This retrospective analysis was conducted in 64 patients diagnosed with type I cryoglobulinaemia (CG) followed at two French centres. Median follow-up was 6·75 years. CG was IgG in 60% and IgM in 40% of all cases and was asymptomatic in 16 patients (25%). Cold-triggered ischaemic skin manifestations were observed in 33 patients (51%). Neurological manifestations were observed in 15 patients and renal manifestations in 13. Most of the patients with necrotic purpura (14/16, P = 0·009) and renal manifestations (11/13, P = 0·057) had IgG CG. IgG CG was associated with monoclonal gammopathy of undetermined significance (MGUS), myeloma, chronic lymphocytic leukaemia and lymphoplasmocytic lymphoma in 18, 13, 5 and 2 patients, respectively. IgM CG was associated with MGUS and Waldenström macroglobulinaemia in 8 and 18 cases, respectively. One third of patients did not receive any specific treatment. Various treatments, including rituximab, were administered to 25/31 patients with IgG CG and 6/25 patients with IgM CG due to CG-related symptoms. Rituximab was ineffective in all cases associated with a predominantly plasmacytic proliferation. To conclude, type I CG has specific clinico-biological characteristics compared to type II CG. Furthermore, there are differences in terms of related manifestations between type I IgG and type I IgM CG. PMID:25363150

Harel, Stephanie; Mohr, Melanie; Jahn, Isabelle; Aucouturier, Francoise; Galicier, Lionel; Asli, Bouchra; Malphettes, Marion; Szalat, Raphael; Brouet, Jean-Claude; Lipsker, Dan; Fermand, Jean-Paul

2015-03-01

24

Clinico-pathological analysis referring hemeoxygenase-1 in acute fibrinous and organizing pneumonia patients  

PubMed Central

Acute fibrinous and organizing pneumonia (AFOP) is a very rare pathological entity of lung injury characterized by intra-alveolar fibrin balls. Hemeoxygenase (HO) -1 is a cytoprotective enzyme against oxidative stress and inflammation. It is known to be expressed in the alveolar macrophages in the healthy adults and overexpressed in other various lung cells of the lung injury patients. We experienced two cases of subacute form AFOP for these 10 years and reviewed clinico-pathological characteristics. The average age was 62 years old and both were male. The etiology of both cases was idiopathic. The average PaO2/FIO2 ratio was 274.5 ± 84.1. The average levels of C-reactive protein and surfactant protein - A of the serum were elevated to 19.8 ± 6.3 mg/dL and 67.6 ± 15.8 ng/mL, respectively. Serum sialylated carbohydrate antigen levels were normal in both cases. The characteristic radiographic findings were bilateral consolidations and ground glass opacities. Lung biopsy specimens revealed fibrin balls and alveolitis with abundant cellular HO-1 expression. Steroid response was excellent and the pulmonary involvements absolutely disappeared for about 3 months.

Hara, Yu; Shinkai, Masaharu; Kanoh, Soichiro; Kawana, Akihiko; Rubin, Bruce K.; Matsubara, Osamu; Kaneko, Takeshi

2015-01-01

25

[Clinico-economical effectiveness of conservative and surgical treatment of duodenal ulcer (results of 5-year study)].  

PubMed

The comparative assessment of the clinico-economical efficiency of the conservative and surgical treatment of the patients with duodenal ulcer disease was carried out. Direct expenses for surgical treatment were 2.5-fold higher than those for conservative treatment. For the five-year period, the expenses for the treatment of recurrences after the use of a conservative method exceeded 2.5-fold those for primary treatment and 4.5-fold--for the late treatment of patients after the operation. PMID:2509781

Polous, Iu M; Shidlovski?, V A; Kurko, V S; Zavadskaia, T S; Lykova, N V

1989-01-01

26

A Clinico-Pathological Study of Lichenoid Tissue Reactions-A Tertiary Care experience  

PubMed Central

Introduction: The aim of this article was to study the spectrum of clinico-histopathological lesions with an age and sex distribution in various lichenoid reactions of the skin. The spectrum of clinical diseases which is related to the lichenoid tissue reaction is wider. There is a recent increase in the relatively new subgroups of the lichenoid clinical picture. Material And Methods: This was a one and a half year prospective study which was conducted in the Dermatopathology Section of the Department of Pathology, from January 2011 to June 2012. All the patients who visited the Dermatology Outpatients/ Inpatients Department and presented with lichenoid tissue reactions were included in the study. The selected patients’ clinical findings were noted and their informed consents and an institutional ethical clearance were taken. Light microscopy was used for the histopathological diagnosis. The SPSS, version 14 software was used to analyze the data. Frequencies and percentages were used to describe the data. Results: During the study period, 107 cases were clinically diagnosed as lichenoid reactions, of which 84 cases were concordant on histopathology and 6 cases were diagnosed, solely based on the histology. So, a total of 90 cases were diagnosed histologically, of which 42 were of the Lichen planus type and 48 were lichenoid eruptions. Females were affected more commonly than the males. Conclusion: In our study, the lichenoid reactions were more common in children and the most common prototype was Lichen planus. So, we conclude that histopathology is a dependable tool for identifying the underlying cause in lichenoid reactions. PMID:23543246

Kumar U, Mahesh; Yelikar, Balasaheb Ramling; Inamadar, Arun C; Umesh, Swaroopa; Singhal, Amrita; Kushtagi, Anirudha V

2013-01-01

27

Dengue Fever Outbreak in Delhi, North India: A Clinico-Epidemiological Study  

PubMed Central

Background: Dengue viruses, single-stranded positive polarity ribonucleic acid (RNA) viruses of the family Flaviviridae, are the most common cause of arboviral disease in the world. We report a clinico-epidemiological study of the dengue fever outbreak of 2010 from a tertiary care hospital in Delhi, North India. Objectives: Objectives of the study were to know the incidence of laboratory-confirmed dengue cases among the clinically suspected patients; to study the clinical profile of dengue-positive cases; and to co-relate the above with the prevalent serotype and environmental conditions. Materials and Methods: Four thousand three hundred and seventy serum samples from clinically suspected cases of dengue infection were subjected to ?-capture enzyme-linked immunosorbent assay (ELISA) for detection of dengue-virus-specific IgM antibodies. Virus isolation was done in 55 samples on C6/36 cell mono-layers. Clinical and demographic details of the patients were obtained from requisition forms of the patients or from treating clinicians. Results: Out of the 4,370 serum samples, 1,700 were positive for dengue-virus-specific IgM antibodies (38.9%). Prevalent serotype was dengue virus type-1. Thrombocytopenia and myalgia was seen in 23.1% and 18.3% of the 1,700 dengue IgM-positive patients, respectively. Also, 10.3% of 1,700 were dengue hemorrhagic fever (DHF) patients; and the mortality in serologically confirmed dengue fever cases was 0.06%. Conclusions: A change in the predominant circulating serotype, unprecedented rains, enormous infrastructure development, and increased reporting due to improved diagnostic facilities were the factors responsible for the unexpected number of dengue fever cases confronted in 2010.

Ahmed, Nishat Hussain; Broor, Shobha

2015-01-01

28

Cytogenetic polyclonality of breast carcinomas: association with clinico-pathological characteristics and outcome.  

PubMed

Routinely used prognostic factors fail to predict clinical outcome in a significant proportion of breast cancer patients, implying that they can not detect some important biological characteristics. Chromosomal changes have been described in breast carcinomas for many years but their significance is not clear. We compared chromosomal changes with clinico-pathological characteristics and clinical outcome in 203 breast cancer patients with a follow-up of 9-18 years. Combining data from classical cytogenetics and flow cytometry revealed chromosomal abnormalities in 142 cases (70%). Of these, 51 (35.9%) contained two or more cytogenetically abnormal clones. Polyclonality was significantly associated with poor breast-cancer-specific survival (P = 0.03) within 5 years, independent of tumor size, lymph node metastases, and hormone receptors. Specific changes were similar to those previously described, but a new finding was a significant association between del 3p12p21 and poor survival. Polyclonality was significantly associated with TP53-mutations but not with a germline BRCA2 mutation. Less than one third of the polyclonal samples were identified by flow cytometry alone. Cytogenetic changes were detected in 17 out of 114 samples from non-tumorous tissue (15%), two of them identical with a clone in the corresponding tumor. Several samples contained clearly unrelated clones within the tumor and outside, implying either multifocal origin or early divergence. In conclusion, the common deletion on Chromosome 3p12p21 was associated with poor clinical outcome. Chromosomal polyclonality is common in breast carcinomas and predicts poor survival. Polyclonality was poorly detected by one-sample flow cytometry. Multiple sampling might improve the detection rate. PMID:21910159

Steinarsdottir, Margret; Gudmundsson, Ingi Hrafn; Jonasson, Jon Gunnlaugur; Olafsdottir, Elinborg J; Eyfjörd, Jorunn E; Ogmundsdottir, Helga M

2011-11-01

29

Evaluation of clinico-pathological features and Helicobacter pylori infection in gastric inflammatory fibroid polyps.  

PubMed

Inflammatory fibroid polyps are rare mesenchymal lesions. The frequency of Helicobacter pylori infection in the gastric mucosa overlying inflammatory fibroid polyps and its relation with the histologic features of the polyps are undetermined. The clinico-pathological features of inflammatory fibroid polyps, the frequency of Helicobacter pylori infection in the overlying gastric mucosa, and its putative impact on the phenotype of the polyps were evaluated. Gastric inflammatory fibroid polyps diagnosed in our Hospital from 1998 to 2012 were reviewed and the histological. The histological sections were stained with hematoxylin and eosin and modified Giemsa for the evaluation of Helicobacter pylori infection. Inconclusive cases were further analyzed by immunohistochemistry with anti-Helicobacter pylori antibody. Diagnosis was confirmed in 54 polyps, 85 % developed in females, mean age 63?±?11 years. Most polyps were sessile (74 %), with a mean size of 15?±?12 mm, 96 % were located in the antrum and 85 % were removed by snare polypectomy. Helicobacter pylori infection was identified in 48 % of the polyps. Most inflammatory fibroid polyps developed in the submucosa, and mucosal extension was observed in 96 % of the cases. Chronic gastritis was observed in all cases (63 % with activity, 31 % with intestinal metaplasia, and 61 % with foveolar hyperplasia). Erosion and ulceration of the overlying gastric mucosa was observed in 48 % and 11 % of the polyps, respectively. Onion skin features were present in 52 % of the polyps and were more frequently observed in cases without evidence of Helicobacter pylori infection. Background changes in gastric mucosa were not distinctive according to Helicobacter pylori infection. Chronic atrophic gastritis with intestinal metaplasia was associated with the presence of perivascular onion skin lesions. To our knowledge, this is the second largest series of gastric inflammatory fibroid polyps. Helicobacter pylori infection was identified in about half of the cases and was associated with a lower frequency of onion skin features in the polyps. PMID:25257403

Albuquerque, Andreia; Rios, Elisabete; Carneiro, Fátima; Macedo, Guilherme

2014-12-01

30

Verrucous lesions of the oral cavity treated with surgery: Analysis of clinico-pathologic features and outcome  

PubMed Central

Objective: Verrucous lesions of the oral cavity can be of varied histopathology. The present study evaluates the clinico-pathological features of verrucous lesions of the oral cavity and analyzes the treatment outcomes. Materials and Methods: This is a retrospective study of 15 consecutive patients who presented with verrucous lesions of the oral cavity, during the 5-year period from January 2006 to December 2010. Demographic, clinico-pathological features, treatment details, and outcomes were analyzed. Results: Fifteen patients with verrucous lesions of the oral cavity were treated with surgery as the primary modality. The mean age was 62.8 years (range 35–85 years). Wide excision of the primary lesion with adequate mucosal and soft-tissue margins was carried out. Free-flap reconstruction was done in eight patients. All patients remain loco-regionally controlled with good functional speech and swallowing outcome. Conclusions: Verrucous lesions of the oral cavity are a distinct clinical entity with varied histopathology. A surgical excision with wide margins and appropriate reconstruction is necessary to optimize the disease and functional outcome. PMID:22557899

Sadasivan, Anjana; Thankappan, Krishnakumar; Rajapurkar, Mayuri; Shetty, Sharankumar; Sreehari, Sreekala; Iyer, Subramania

2012-01-01

31

Il significato clinico della curva glicemica da carico endovena di tolbutamide  

Microsoft Academic Search

Riassunto Gli Autori studiano le modificazioni glicemiche dopo somministrazione endovena di un grammo di tolbutamide in soggetti normali, in diabetici ed in pazienti con malattie diverse. Iltest alla tolbutamide presenta discrete modificazioni della curva glicemica sia nei soggetti normali con età al di sopra dei 60 anni che in pazienti affetti da emopatie, tireopatie, acromegalia, cirrosi epatica.

Pietro Polosa; Luciano Motta; Ernesto Turrisi

1965-01-01

32

Clinico-demographic profile, sexual dysfunction and readiness to change in male alcohol dependence syndrome inpatients in a tertiary hospital.  

PubMed

Persons with prolonged and heavy alcohol use generally suffer from alcohol dependence syndrome (ADS) and develop physical, sexual as well as psychiatric co-morbidity. Successful recovery to normalcy depends on multiple factors including patient's motivation. To study clinico-demographic profile, reasons for initiating alcohol use, sexual and psychiatric disorders and eagerness for treatment and quitting alcohol in ADS inpatients. Fifty consecutive ADS inpatients with matching controls were enrolled. Clinico-demographic profile, factors for initiating alcohol use, psychiatric and sexual co-morbidity and want for treatment and being abstinent was studied applying relevant scales. All subjects were males with a mean age of 37.5 years, 80% were married, majority were Hindu (88%) and from nuclear families (56%). Fifty two percent had an education level of Graduation or more and 68% of patients reported peer pressure to be the initiating factor for alcohol use. Seventy six percent had psychiatric co-morbidity including personality Problems and other Psychiatric disorders 19(38%), delirium tremens 14 (28.00%) and Mood disorders 12(24%).Depression being most common mood disorder (14%). Nicotine was the most common other substance of use 32 (64%). Sixty eight percent of the patient reported one or another sexual dysfunction. 68% of ADS inpatients acknowledged of having problems related to their drinking, expressed desire for change and were eager to avail treatment and to remain abstinent. ADS patients commonly suffer from psychiatric co-morbidity and sexual dysfunctions. They also wish to have effective treatment and to quit alcohol. PMID:23441492

Pandey, A K; Sapkota, N; Tambi, A; Shyangwa, P M

2012-03-01

33

IN VITRO SENSITIVITY OF CHRONIC LYMPHOCYTIC LEUKEMIA B-CELLS TO FLUDARABINE, 2-CHLORODEOXYADENOSINE AND CHLORAMBUCIL: CORRELATION WITH CLINICO-HEMATOLOGICAL AND IMMUNOPHENOTYPIC FEATURES  

Microsoft Academic Search

Background. Chlorambucil (CLB), 2-chlorodeoxyadenosine (2-CDA) and fludarabine (FAMP) are among the most widely used drugs in chronic lymphocytic leukemia (CLL). Therefore we evaluated in vitro sensitivity to these drugs and cross-resistance of purine analogs. In addition, we correlated the in vitro data with the main clinico-hematological variables and surface markers. Patients and Methods. Eighty CLL samples obtained from 63 untreated

Fortunato Morabito; Caterina Stelitano; Ida Callea; Monica Filangeri; Bianca Oliva; Giuseppina Sculli; Vincenzo Callea; Francesco Nobile; Maura Brugiatelli

34

Charcot–Marie–Tooth disease type 2J with MPZ Thr124Met mutation: clinico-electrophysiological and MRI study of a family  

Microsoft Academic Search

The purpose of the present study was to describe clinico-electrophysiological features and lower limb muscle MRI findings\\u000a in a CMT2J pedigree due to MPZ Thr124Met mutation. We examined the proband, aged 56 years, and her affected daughter and son, aged 30 and 29 years. Disease\\u000a severity in terms of ability to walk and run was established using a nine-point functional disability scale

Elena Gallardo; Antonio García; César Ramón; Elías Maraví; Jon Infante; Itziar Gastón; Ángel Alonso; Onofre Combarros; Peter De Jonghe; José Berciano

2009-01-01

35

Molecular profiles of BRCA1-mutated and matched sporadic breast tumours: relation with clinico-pathological features  

PubMed Central

About 5–10% of breast cancers are hereditary; a genetically and clinically heterogeneous disease in which several susceptibility genes, including BRCA1, have been identified. While distinct tumour features can be used to estimate the likelihood that a breast tumour is caused by a BRCA1 germline mutation it is not yet possible to categorize a BRCA1 mutated tumour. The aim of the present study is to molecularly classify BRCA1 mutated breast cancers by resolving gene expression patterns of BRCA1 and matched sporadic surgical breast tumour specimens. The expression profiles of 6 frozen breast tumour tissues with a proven BRCA1 gene mutation were weighed against those from 12 patients without a known family history but who had similar clinico-pathological characteristics. In addition two fibroblast cultures, the breast cancer cell-line HCC1937 and its corresponding B-lymphoblastoid cell line (heterozygous for mutation BRCA1 5382insC) and an epithelial ovarian cancer cell line (A2780) were studied. Using a high density membrane based array for screening of RNA isolated from these samples and standard algorithms and software, we were able to distinguish subgroups of sporadic cases and a group consisting mainly of BRCA1-mutated breast tumours. Furthermore this pilot analysis revealed a gene cluster that differentially expressed genes related to cell substrate formation, adhesion, migration and cell organization in BRCA1-mutated tumours compared to sporadic breast tumours. © 2001 Cancer Research Campaign http://www.bjcancer.com PMID:11506493

Berns, E M J J; Staveren, I L van; Verhoog, L; Ouweland, A M W van de; Gelder, M Meijer-van; Meijers-Heijboer, H; Portengen, H; Foekens, J A; Dorssers, L C J; Klijn, J G M

2001-01-01

36

An eight-year snapshot of geospatial cancer research (2002-2009): clinico-epidemiological and methodological findings and trends.  

PubMed

Geographic information systems (GIS) offer a very rich toolbox of methods and technologies, and powerful research tools that extend far beyond the mere production of maps, making it possible to cross-link and study the complex interaction of disease data and factors originating from a wide range of disparate sources. Despite their potential indispensable role in cancer prevention and control programmes, GIS are underrepresented in specialised oncology literature. The latter has provided an impetus for the current review. The review provides an eight-year snapshot of geospatial cancer research in peer-reviewed literature (2002-2009), presenting the clinico-epidemiological and methodological findings and trends in the covered corpus (93 papers). The authors concluded that understanding the relationship between location and cancer/cancer care services can play a crucial role in disease control and prevention, and in better service planning, and appropriate resource utilisation. Nevertheless, there are still barriers that hinder the wide-scale adoption of GIS and related technologies in everyday oncology practice. PMID:20589539

Boulos, Dina N Kamel; Ghali, Ramy R; Ibrahim, Ezzeldin M; Boulos, Maged N Kamel; AbdelMalik, Philip

2011-12-01

37

PAH exposure biomarkers are associated with clinico-chemical changes in the brick kiln workers in Pakistan.  

PubMed

In this study we investigated the clinico-chemical parameters and the level of exposure of brick kiln workers to polycyclic aromatic hydrocarbons (PAHs) in Punjab (Pakistan). The brick kiln workers and a non-occupationally exposed group were recruited for comparative analysis of urinary biomarkers of PAH exposure (i.e. 1-hydroxypyrene (1-OHPyr), ?-naphthol and ?-naphthol) and blood level of superoxide dismutase (SOD), as a biomarker of oxidative stress and other hematologic parameters. Questionnaires were used to document information on socio-demographic characteristics of all the subjects. The analysis of urinary biomarkers showed higher median concentrations of 1-OHPyr, and ?- and ?-naphthols in brick kiln workers (1.53, 3.65 and 1.53 ?mol/mol-Cr, respectively) than non-occupationally exposed group (0.62, 0.64 and 0.66 ?mol/mol-Cr, respectively). The 1-OHPyr in brick kiln workers was above the occupational exposure level. Among the clinical parameters of brick kiln workers, hemoglobin (Hb) and red blood cells (RBCs) were very low and closely associate with 1-OHPyr and ?-naphthol. Additionally, the white blood cells (WBCs) and superoxide dismutase (SOD) were also elevated in brick kiln workers, which suggested inflammatory symptoms and high oxidative stress. The results show that regardless of possibly being affected by the poor nutrition, the anemic state and hematological changes observed in brick kiln workers may be associated with their exposure to smoke present in the environment of brick kilns. PMID:24878696

Kamal, Atif; Malik, Riffat Naseem; Martellini, Tania; Cincinelli, Alessandra

2014-08-15

38

Rare and challenging extra-axial brain lesions: CT and MRI findings with clinico-radiological differential diagnosis and pathological correlation.  

PubMed

There are many kinds of extra-axial brain tumors and tumor-like lesions, and definitive diagnosis is complicated in some cases. In this pictorial essay, we present rare and challenging extra-axial brain lesions including neuroenteric cyst, primary leptomeningeal melanomatosis, isolated dural neurosarcoidosis, intradiploic epidermoid cyst, ruptured dermoid cyst, intraventricular cavernoma, and cavernous hemangioma of the skull with imaging findings and clinico-radiological differential diagnosis, including the pathologic correlation. Familiarity with these entities may improve diagnostic accuracy and patient management. PMID:25010368

Demir, Mustafa Kemal; Yap?c?er, Ozlem; Onat, Elif; Tokta?, Zafer Orkun; Akak?n, Ak?n; Urgun, Kamran; K?l?ç, Türker

2014-01-01

39

Clinico-pathomorphological, serum biochemical and histological studies in broilers fed ochratoxin A and a toxin deactivator (Mycofix Plus).  

PubMed

1. Toxic effects of two concentrations (0.5 and 1 mg/kg) of ochratoxin A (OTA) and attenuating effects of a toxin deactivator (Mycofix Plus(MTV INSIDE)) containing the yeast Trichosporon mycotoxinivorans on the performance (feed conversion ratio; body weight gain), serum enzymes (lactate dehydrogenase, gamma-glutamyltranspeptidase and aspartate aminotransferase) and clinico-pathomorphology of internal organs were studied in 270 one-day-old broiler chicks divided into 9 groups over a 42-d period. 2. Feed conversion ratios (FCR) in groups fed toxin deactivator were improved compared with groups receiving OTA only. An increase in the relative weight of kidney and liver was observed in groups fed 0.5 and 1 mg/kg OTA on day 42 of the experiment as compared with the control group. In contrast, relative weights of bursa of Fabricius and spleen were not significantly affected in experimental groups exposed to OTA as compared to control groups determined on days 28 and 42 of age. 3. Serum enzymes (LDH, GGT and AST) values in OTA treated groups determined on days 28 and 42 were higher than those of the control group. 4. Histopathological examination of kidney on day 42 revealed degenerative changes in the epithelial cells of the proximal convoluted tubules and massive necrosis of the proximal tubular epithelial cells. These changes were less marked in birds receiving 0.5 mg/kg OTA than in those receiving 1 mg/kg. In general, histological changes in kidneys, liver, bursa and spleen were less pronounced in birds receiving OTA and toxin deactivator concomitantly. 5. Dietary OTA at 0.5 and 1 mg/kg adversely affects FCR, increases the serum liver enzymes and induces pronounced pathomorphological and histological changes in internal organs of broiler chicks. Co-administration of OTA with deactivator attenuated the harmful effects. PMID:18836911

Hanif, N Q; Muhammad, G; Siddique, M; Khanum, A; Ahmed, T; Gadahai, J A; Kaukab, G

2008-09-01

40

Chronic lymphocytic leukemia in the elderly: clinico-biological features, outcomes, and proposal of a prognostic model  

PubMed Central

We investigated the clinico-biological features, outcomes, and prognosis of 949 patients with chronic lymphocytic leukemia according to age. No biological differences (cytogenetics by fluorescent in situ hybridization, IGHV, ZAP-70, CD38, NOTCH1, SF3B1) were found across age groups. Elderly patients (>70 years; n=367) presented more frequently with advanced disease (Binet C/Rai III-IV: 10/12% versus 5/5%; P<0.001), were treated less frequently (23.8% versus 41.9% at 3 years; P<0.001) and in most cases did not receive highly effective regimens and thus had a lower overall response rate (49% with 14% having complete responses versus 69% with 31% having complete responses; P<0.001). The elderly patients also had a shorter overall survival (6.6 versus 13.3 years; P<0.001) and higher disease-unrelated mortality (34.9% versus 6.9% at 10 years; P<0.001). However, disease-attributable mortality was not significantly different between younger and older patients. A combination of Binet stage, ZAP-70 level, ?2-microglobulin concentration and comorbidity identified two risk groups (low-risk: 0–1 parameters; high-risk: 2–4 parameters) with different overall survivals (median: 6.8 versus 11.4 years, P<0.001). In patients requiring treatment, comorbidity at treatment (Cumulative Illness Rating Scale-T>4; hazard ratio 2.2, P<0.001) and response (treatment failure versus response: hazard ratio 1.60, P<0.04) were the most important prognostic factors for overall survival. In conclusion, in our series, elderly patients with chronic lymphocytic leukemia did not present with any biological features distinct from those of younger patients, but did have a poorer clinical outcome. This study highlights the importance of comprehensive medical care, achieving response to therapy, and specific management strategies for elderly patients with chronic lymphocytic leukemia. PMID:24972773

Baumann, Tycho; Delgado, Julio; Santacruz, Rodrigo; Martínez-Trillos, Alejandra; Royo, Cristina; Navarro, Alba; Pinyol, Magda; Rozman, María; Pereira, Arturo; Villamor, Neus; Aymerich, Marta; López, Cristina; Carrió, Anna; Montserrat, Emili

2014-01-01

41

[Clinico-pathological studies on the effects of calcium hydroxide eugenol preparations to the human vital pulp tissues].  

PubMed

The present paper reports results of a study to evaluate clinico-pathologically the effects of calcium hydroxide eugenol preparations on exposed pulp tissues in permanent human teeth. The experiments were performed on 80 vital human teeth from patients ranging in age from 12 to 54 years. The experimental teeth were arbitrarily divided into the following 4 groups. Group CRCS: 20 cases treated with CRCS (Hygienic, Akron, Ohio, USA). Group KEZ: 20 cases treated with Dentalis KEZ (Neo Dental Chemical Products, Tokyo, Japan). Group CE: 20 cases treated with calcium hydroxide eugenol (positive control) Group E: 20 cases treated with pure eugenol (negative control). After local anesthesia, the experimental teeth were isolated with rubber dums or cotton rolls. Following preparation of Black's simple class 1 cavities with a diamond instrument mounted high-speed air turbine, the pulp was intentionally exposed by means of a steel bur mounted electric engine. The cavity and exposed pulp surface were cleaned with saline and dried on absorbent material. Then the experimental materials (agents) were applied to exposed pulp surface. The cavity was lined with gutta-percha temporally stopping, and the remainder was filled with silver amalgam. The teeth were clinically observed at various intervals from immediately to 530 days after treatment and then extracted under local anesthesia and prepared for histopathological study. Decalcified sections were stained with hematoxylin and eosin. 1) CLINICAL OBSERVATIONS: During the observation period, symptoms occurred in the following: Group CRCS: 4 (20%) out of 20 cases. Group KEZ: 4 (20%) out of 20 cases. Group CE: 6 (30%) out of 20 cases. Group E: None of 20 cases No spontaneous pain was observed in these groups. 2) Clinical evaluations Group: CRCS: 16 cases (80%) were good, 3 cases (15%) were satisfactory, and 1 cases (5%) were failure. Group KEZ: 16 cases (80%) were good, 1 cases (5%) were satisfactory, and 3 cases (15%) were failure. Group CE: 14 cases (70%) were good, 4 cases (20%) were satisfactory, and 2 cases (10%) were failure. Group E: 20 cases (100%) were good. 3) Histopathological observations. Various kinds and degree of pulp changes were occurred in each group. Hyperemia and round-cell infiltration resulting from damage caused by treatment and medicaments were frequent in each group. No suppurative inflammation occurred in group CE. Pulp cicatrization and apposition of dentin on pulp chamber walls were observed frequently in each groups. Hard tissue formation was observed in numerous cases of group CE and in some cases in group CRCS and KEZ.(ABSTRACT TRUNCATED AT 400 WORDS) PMID:2635382

Minagawa, M

1989-05-01

42

The clinico-pathological spectrum of Focal Cortical Dysplasias: a consensus classification proposed by an ad hoc Task Force of the ILAE Diagnostic Methods Commission  

PubMed Central

Focal cortical dysplasias (FCDs) are localized regions of malformed cerebral cortex and are very frequently associated with epilepsy in both children and adults. A broad spectrum of histopathology has been included in the diagnosis of FCD. Characteristic findings include aberrant radial or tangential lamination of the neocortex (FCD Type I) and cytological abnormalities (FCD Type II). An ILAE task force has re-evaluated available data and proposes a clinico-pathologic classification system of FCDs. The major change since a prior classification represents the introduction of FCD Type III, which occurs in combination with Hippocampal Sclerosis (FCD Type IIIa), or with epilepsy-associated tumors (FCD Type IIIb). FCD Type IIIc is found adjacent to vascular malformations, whereas FCD Type IIId can be diagnosed in association with epileptogenic lesions acquired in early life (i.e., traumatic injury, ischemic injury or encephalitis). Hence, FCD Type I will now refer to isolated lesions, which present either as radial (FCD Type Ia) or tangential (FCD Type Ib) dyslamination of the neocortex, microscopically identified in one or multiple lobes. FCD Type II is an isolated lesion characterized by cortical dyslamination and dysmorphic neurons without (Type IIa) or with balloon cells (Type IIb). Architectural abnormalities adjacent to or within gross malformations of cortical development are frequently observed and not distinguished as a specific FCD variant. This three-tiered classification system will help to better characterize specific clinico-pathological entities and is an important basis to further explore imaging, electro-clinical features, and postsurgical seizure control as well as underlying molecular pathomechanisms. PMID:21219302

Blümcke, Ingmar; Thom, Maria; Aronica, Eleonora; Armstrong, Dawna D.; Vinters, Harry V.; Palmini, Andre; Jacques, Thomas S; Avanzini, Giuliano; Barkovich, A. James; Battaglia, Giorgio; Becker, Albert; Cepeda, Carlos; Cendes, Fernando; Colombo, Nadia; Crino, Peter; Cross, J. Helen; Delalande, Olivier; Dubeau, François; Duncan, John; Guerrini, Renzo; Kahane, Philippe; Mathern, Gary; Najm, Imad; Özkara, Çi?dem; Raybaud, Charles; Represa, Alfonso; Roper, Steven N.; Salamon, Noriko; Schulze-Bonhage, Andreas; Tassi, Laura; Vezzani, Annamaria; Spreafico, Roberto

2010-01-01

43

A Study on Clinico-Mycological Profile, Aetiological Agents and Diagnosis of Onychomycosis at a Government Medical College Hospital in Kashmir  

PubMed Central

Background: Onychomycosis is a major public health problem with a high incidence, associated morbidity and a long lasting treatment with anti-fungal agents. This study was carried out to know the clinico-mycological pattern of onychomycosis, which could help in the control of this infection. Aims: The aim of this study was to determine the prevalence of various causative agents of onychomycosis and to study the clinical and mycological patterns of onychomycosis. Material and Methods: This was a prospective study which was carried over a period of one year, from 1st February 2011 to 31st January 2012 on samples from 150 patients with clinically suspected nail infections, who attended the Dermatology Department of SKIMS Medical college, Kashmir, India. The nails were evaluated clinically and the nail samples were subjected to direct microscopy and culture. Results: 60% samples were found to be positive by direct microscopy and culture. Males were infected more than females. The commonest age group which was infected was the 21-30 years age group. Finger nails were affected more frequently than toe nails and distolateral subungal onychomycosis was the most common clinical type of infection which was seen in 64.44% patients. The aetiological agents were dermatophytes (61.66%), Non–Dermatophyte Moulds (NDM) (31.66%) and yeasts (6.66%). Among dermatophytes, T. rubrum was the commonest aetiological agent. Conclusion: Although dermatophytes were the main causative agents, NDM and yeasts were also not uncommon aetiological agents of onychomycosis. This study also emphasized the need of performing both a direct examination and culture to improve sensitivity. Since onychomycosis can cause physical, psycological and occupational problems, the clinico-epidemiological data can be helpful in development of preventive and diagnostic strategies. PMID:24179915

Lone, Rubeena; Bashir, Deeba; Ahmad, Shabir; Syed, Arshi; Khurshid, Syed

2013-01-01

44

Spindle cell lipoma-like tumor, solitary fibrous tumor and myofibroblastoma of the breast: a clinico-pathological analysis of 13 cases in favor of a unifying histogenetic concept  

Microsoft Academic Search

We reviewed the clinico-pathological features of a series of 13 cases of benign spindle stromal tumors (BSSTs) of the breast relating to a basic common theme consisting of a well-circumscribed proliferation of vimentin+\\/CD34+\\/BCL-2+\\/CD99+ spindly to oval-epithelioid cells, variably arranged in haphazard to short fascicular growth pattern, with interspersed thick or thin collagen bands. Morphological variations included atypical mono- or multi-nucleated

Gaetano Magro; Michele Bisceglia; Michal Michal; Vincenzo Eusebi

2002-01-01

45

Serous neoplasms of the pancreas constitute a continuous spectrum of morphological patterns rather than distinct clinico-pathological variants. A study of 40 cases.  

PubMed

Serous neoplasms (SN) of the pancreas account for 1-2% of all pancreatic tumours. Six morphological variants of SN were previously recognized: serous microcystic (cyst)adenoma, serous macrocystic (cyst)adenoma, von Hippel-Lindau-associated serous cystic neoplasm, solid serous adenoma/neoplasm, mixed serous-neuroendocrine neoplasm and serous cystadenocarcinoma. It was recently postulated that SN shows a continuous spectrum of morphological patterns rather than distinct clinico-pathological subtypes. To address this issue, we performed a detailed review of 40 SN cases diagnosed at our institution between 1989 and 2011. We found 11 cases of serous microcystic (cyst)adenoma, 5 cases of serous macrocystic (cyst)adenoma, and a single case of von Hippel-Lindau-associated serous cystic neoplasm. Apart from that, we found 20 cases of SN which showed features of both microcystic and macrocystic (cyst)adenomas, 2 cases of small 'incipient' SN and a single case of a mixed microcystic and solid adenoma. In conclusion, we showed that 'borderline' lesions among SNs truly exist and are not rare. The reason for such a wide diversity of morphological patterns of SN remains unknown. PMID:22246906

Paj?k, Jacek; Liszka, ?ukasz; Mrowiec, S?awomir; Zieli?ska-Paj?k, Ewa; Go?ka, Dariusz; Lampe, Pawe?

2011-12-01

46

Entrevista con Ricardo Halac  

E-print Network

capitalismo, que cada vez es más abstracto, financiero, ingobernable. Pero el racionalismo subsiste en su vieja forma en el pensamiento de izquierda: en la Unión Soviética, en China, en las democracias populares, se está "construyendo11 el hombre nuevo. En... 1968, con la muerte del "Che" Guevara en Bolivia, luego de una campaña "racionalmente" perfecta, los bolivianos se tenían que insubordinar y seguirlo. Entra en crisis entonces el pensamiento racional en el mundo entero. Hasta las grandes religiones...

Glickman, Nora

1990-04-01

47

¡Truco Con Agua!  

NSDL National Science Digital Library

En esta actividad los aprendices aprenderán un truco de magia donde la magia es la presión del aire. Los participantes tomarán un vaso de agua medio lleno y lo taparán con un pedazo de plástico o cartón. Sosteniendo la tarjeta contra el vaso, lo voltearán boca abajo y cuando quiten la mano debajo del vaso, ¡abracadabra! no se caerá el agua. En la tira cómica, Mateo explica a los aprendices que la presión que hace el aire en todas las direcciones es la que sostiene la tarjeta.

Lawrence Hall of Science

2009-01-01

48

Entrevista con Enrique Buenaventura  

E-print Network

dramaturgia práctica grupai y su extensa labor docente, han ido resultando en un considerable y ponderado corpus teórico sobre la íntima relación del discurso teatral y la historia, especialmente esa historia truncada, manipu lada y camuflada por poderosos... mucho más. Esta manera suya de actuar hizo que todo el mundo se metiera en la guerra y de una manera muy decidida. Entonces se empezó a producir la desmoralización de la Guardia. Como si hubieran ido demasiado lejos con la represión y la matanza. Sí...

Dí ez, Luys A.

1981-04-01

49

Alteration in clinico-biochemical profile and oxidative stress indices associated with hyperglycaemia with special reference to diabetes in cattle--a pilot study.  

PubMed

The present study aimed to assess hyperglycaemia with special reference to diabetes mellitus in cattle by clinico-biochemical estimation and evaluation of oxidative stress indices. A total of 256 cattle exhibiting weakness, poor body condition and reduced milk yield in lactating cattle were included in the study. These animals were screened with blood glucose level, urine glucose and ketone bodies. Out of these, 32 (12.5%) cattle showed hyperglycaemia and glycosuria, of which 25% exhibited ketonuria. Diabetes was confirmed in five cattle by estimation of fasting blood glucose, glycated haemoglobin, serum fructosamine, intravenous glucose tolerance test and insulin level. This reports first confirmation of diabetes in cattle in India. All these five animals revealed low level of serum insulin suggestive of insulin-dependent diabetes mellitus in cattle. The level of aspartate aminotransferase (AST) and gamma glutamyl transferase (GGT) was found to be increased in diabetic cattle. Oxidant/antioxidant balance was assessed in hyperglycaemic cattle and five age-matched Holstein Friesian (HF) cross-bred healthy control animals. Diabetic cattle revealed significantly higher (P???0.01) levels of erythrocytic lipid peroxides in comparison with other hyperglycaemic cattle and healthy controls whereas the level of superoxide dismutase (SOD) and catalase was found to be significantly lower in diabetes-affected animals in comparison to healthy controls. Reduced glutathione did not show a significant difference between hyperglycaemic and control groups. It is concluded from the present study that oxidative stress associated with diabetes in cattle is obvious compared with other hyperglycaemic cattle. PMID:25433646

Deepa, Padinjare Melepat; Dimri, Umesh; Jhambh, Ricky; Yatoo, Mohd Iqbal; Sharma, Bhaskar

2015-01-01

50

Clinico-epidemiological profile and diagnostic procedures of pediatric tuberculosis in a tertiary care hospital of western Nepal-a case-series analysis  

PubMed Central

Background Changing epidemiology and diagnostic difficulties of paediatric tuberculosis (TB) are being increasingly reported. Our aim was to describe clinico-epidemiological profile and diagnostic procedures used for paediatric TB. Methods A retrospective case-series analysis was carried out in a tertiary care teaching hospital of western Nepal. All pediatric TB (age 0-14 years) patients registered in DOTS clinic during the time period from March, 2003 to July, 2008 were included. Medical case files were reviewed for information on demography, clinical findings, investigations and final diagnosis. Analysis was done on SPSS package. Results were expressed as rates and proportions. Chi square test was used to test for statistical significance. Results About 17.2% (162/941) of TB patients were children. Common symptoms were cough, fever and lymph node swelling. The types of TB were pulmonary TB (46.3%, 75/162), followed by extra-pulmonary TB (41.4%, 67/162). Twelve patients (7.4%) had disseminated TB. Distribution of types of TB according to gender was similar. PTB was common in younger age than EPTB which was statistically significant. EPTB was mainly localized to lymph node (38, 50.7%), and abdomen (9, 12%). Five main investigations namely Mantoux test, BCG test, chest radiograph, erythrocyte sedimentation rate (ESR) and fine needle aspiration cytology (FNAC) or biopsy were carried out to diagnose TB. Conclusions Paediatric TB in both pulmonary and extrapulmonary forms is a common occurrence in our setting. Age incidence according to type of TB was significant. Diagnosis was based on a combination of epidemiological and clinical suspicion supported by results of various investigations. PMID:20696041

2010-01-01

51

Clinico-biological features of 5202 patients with acute lymphoblastic leukemia enrolled in the Italian AIEOP and GIMEMA protocols and stratified in age cohorts  

PubMed Central

The outcome of children and adults with acute lymphoblastic leukemia is markedly different. Since there is limited information on the distribution of clinico-biological variables in different age cohorts, we analyzed 5202 patients with acute lymphoblastic leukemia enrolled in the Italian multicenter AIEOP and GIMEMA protocols and stratified them in nine age cohorts. The highest prevalence of acute lymphoblastic leukemia was observed in children, although a second peak was recorded from the 4th decade onwards. Interestingly, the lowest incidence was found in females between 14–40 years. Immunophenotypic characterization showed a B-lineage in 85.8% of patients: a pro-B stage, associated with MLL/AF4 positivity, was more frequent in patients between 10–50 years. T-lineage leukemia (14.2%) was rare among small children and increased in patients aged 10–40 years. The prevalence of the BCR/ABL1 rearrangement increased progressively with age starting from the cohort of patients 10–14 years old and was present in 52.7% of cases in the 6th decade. Similarly, the MLL/AF4 rearrangement constantly increased up to the 5th decade, while the ETV6/RUNX1 rearrangement disappeared from the age of 30 onwards. This study shows that acute lymphoblastic leukemia in adolescents and young adults is characterized by a male prevalence, higher percentage of T-lineage cases, an increase of poor prognostic molecular markers with aging compared to cases in children, and conclusively quantified the progressive increase of BCR/ABL+ cases with age, which are potentially manageable by targeted therapies. PMID:23716539

Chiaretti, Sabina; Vitale, Antonella; Cazzaniga, Gianni; Orlando, Sonia Maria; Silvestri, Daniela; Fazi, Paola; Valsecchi, Maria Grazia; Elia, Loredana; Testi, Anna Maria; Mancini, Francesca; Conter, Valentino; te Kronnie, Geertruy; Ferrara, Felicetto; Di Raimondo, Francesco; Tedeschi, Alessandra; Fioritoni, Giuseppe; Fabbiano, Francesco; Meloni, Giovanna; Specchia, Giorgina; Pizzolo, Giovanni; Mandelli, Franco; Guarini, Anna; Basso, Giuseppe; Biondi, Andrea; Foà, Robin

2013-01-01

52

Mixed exocrine-neuroendocrine carcinoma of the nasal cavity: clinico-pathologic and molecular study of a case and review of the literature.  

PubMed

Sinonasal intestinal-type adenocarcinomas (ITACs) are rare neoplasms histologically resembling intestinal adenocarcinomas. Although a neuroendocrine differentiation in ITACs has been described, true mixed exocrine-neuroendocrine carcinomas, neoplasms in which each component represents at least 30 % of the lesion, are extremely rare and their molecular alterations are largely unknown. We describe herein the clinico-pathologic features, the methylation profile, chromosomal gains and losses, and mutation analysis of KRAS, BRAF and p53 in a nasal mixed exocrine-neuroendocrine carcinoma resected in a 79-year-old man. The tumor was composed of an ITAC and a poorly differentiated neuroendocrine carcinoma. Both exocrine and neuroendocrine components were CK8, CK20, CDX2 and p53 positive, and CK7 and TTF1 negative. The neuroendocrine component also showed immunoreactivity for chromogranin A, synaptophysin, serotonin and glicentin. Gains and losses were found at following chromosome regions: 17p13 (TP53), 14q24 (MLH3), 19q13 (KLK3), 5q21 (APC), 7q21 (CDK6), 9q34 (DAPK1), 12p13 (TNFRSF 1A, CDKN1B), 13q12 (BRCA2), 17p13.3 (HIC1), 18q21 (BCL2), and 22q12 (TIMP3). Aberrant methylation was detected only in the neuroendocrine component and involved APC and DAPK1 genes. No mutation of KRAS (exons 2-4), BRAF (exon 15), and p53 (exons 4-10) was found in both components. The results suggest a monoclonal origin of the tumor from a pluripotent cell undergoing a biphenotypic differentiation and that the neuroendocrine differentiation may be from an exocrine to an endocrine pathway. We have also reviewed the literature on sinonasal mixed exocrine-neuroendocrine carcinomas to give to the reader a comprehensive overview of these very rare tumor types. PMID:22740238

La Rosa, Stefano; Furlan, Daniela; Franzi, Francesca; Battaglia, Paolo; Frattini, Milo; Zanellato, Elena; Marando, Alessandro; Sahnane, Nora; Turri-Zanoni, Mario; Castelnuovo, Paolo; Capella, Carlo

2013-03-01

53

Charcot–Marie–Tooth disease type 2J with MPZ Thr124Met mutation: clinico-electrophysiological and MRI study of a family.  

PubMed

The purpose of the present study was to describe clinico-electrophysiological features and lower limb muscle MRI findings in a CMT2J pedigree due to MPZ Thr124Met mutation. We examined the proband, aged 56 years, and her affected daughter and son, aged 30 and 29 years. Disease severity in terms of ability to walk and run was established using a nine-point functional disability scale (FDS). We administered the CMT neuropathy score (CMTNS) based on patient's symptoms, neurologic examination and neurophysiologic testing. All three patients had non-symptomatic Adie's pupil. The proband and her son presented with late-onset lower limb sensorimotor neuropathy and pes cavus; the proband's daughter had no signs of polyneuropathy. FDS score was 4 in the proband, 2 in her son, and 0 (normal) in her daughter. In both symptomatic patients, electrophysiological study showed a pattern of length-dependent axonal neuropathy mainly involving lower limb nerves; this was normal in the other patient. CMTNS was 18 in the proband, 12 in her son, and 0 (normal) in her daughter. MRI of foot and leg musculature was normal in the proband's daughter, whereas the other two patients showed massive fatty atrophy of intrinsic foot musculature, extensive and diffuse fatty atrophy of leg muscles in the proband, and mild distally accentuated fatty infiltration of calf muscles in her son. Muscle edema, detected only in the proband's son, was present in 7 out of 22 (33%) of visualized leg muscles, whereas contrast enhancement occurred in 6 of them. The reported mutation may manifest with either isolated Adie's pupil or pupil abnormalities with late-onset sensorimotor length-dependent axonal polyneuropathy, though the presence of pes cavus might indicate an earlier onset. MRI examination helps to delineate an accurate extent of muscle involvement in the disease. PMID:19629567

Gallardo, Elena; García, Antonio; Ramón, César; Maraví, Elías; Infante, Jon; Gastón, Itziar; Alonso, Ángel; Combarros, Onofre; De Jonghe, Peter; Berciano, José

2009-12-01

54

Evaluation of Serum Levels of HER2, MMP-9, Nitric Oxide, and Total Antioxidant Capacity in Egyptian Breast Cancer Patients: Correlation with Clinico-Pathological Parameters  

PubMed Central

Breast cancer is by far the most common cancer in women worldwide and the main cause of cancer-related mortality. Breast cancer accounts for 38% of all malignancies among Egyptian women. The aim of our study was to evaluate the serum levels of human epidermal growth factor receptor-2 (HER2), matrix metalloproteinase-9 (MMP-9), nitric oxide (NO), and total antioxidant capacity (TAC) in breast cancer patients and to correlate these markers with clinico-pathological parameters. Serum HER2, MMP-9, and carcinoma antigen 15-3 (CA 15-3) were assessed in 80 breast cancer patients and ten healthy subjects as a control group by the enzyme-linked immunosorbent assay (ELISA) technique while NO and TAC were assessed by a colorimetric method. Serum HER2 was ?15 ng/mL in nine patients (11.3%). High HER2 ECD levels were significantly associated with tissue HER2 (P<0.0001), metastasis (P= 0.0024), and negativity of both estrogen (P=0.0075) and progesterone (P=0.0239) receptors. Serum MMP-9 (P=0.0013), NO (P<0.0001), and CA 15-3 (P<0.0001) were significantly increased while serum TAC was significantly (P=0.01) decreased in breast cancer patients as compared to the control group. Serum MMP-9 was increased significantly (P=0.028) in metastatic patients as compared to non-metastatic patients. We found a positive correlation between serum HER2 and CA 15-3 (r=36, p=0.005). In conclusion, serum HER2 reflects the tissue HER2 status of breast cancer, so the determination of serum HER2 is helpful in assessing HER2 status, but in addition, a high level may reflect metastatic disease. Also, serum MMP-9 can be useful for denoting the development of metastasis in breast cancer patients. Follow-up is needed to evaluate the value of serum HER2 and MMP-9 as prognostic markers. PMID:24634847

Rashad, Yara A.; Elkhodary, Tawfik R.; El-Gayar, Amal M.; Eissa, Laila A.

2014-01-01

55

Recent outbreak of cutaneous anthrax in Bangladesh: clinico-demographic profile and treatment outcome of cases attended at Rajshahi Medical College Hospital  

PubMed Central

Background Human cutaneous anthrax results from skin exposure to B. anthracis, primarily due to occupational exposure. Bangladesh has experienced a number of outbreaks of cutaneous anthrax in recent years. The last episode occurred from April to August, 2011 and created mass havoc due to its dreadful clinical outcome and socio-cultural consequences. We report here the clinico-demographic profile and treatment outcome of 15 cutaneous anthrax cases attended at the Dermatology Outpatient Department of Rajshahi Medical College Hospital, Bangladesh between April and August, 2011 with an aim to create awareness for early case detection and management. Findings Anthrax was suspected primarily based on cutaneous manifestations of typical non-tender ulcer with black eschar, with or without oedema, and a history of butchering, or dressing/washing of cattle/goat or their meat. Diagnosis was established by demonstration of large gram-positive rods, typically resembling B. anthracis under light microscope where possible and also by ascertaining therapeutic success. The mean age of cases was 21.4?years (ranging from 3 to 46?years), 7 (46.7%) being males and 8 (53.3%) females. The majority of cases were from lower middle socioeconomic status. Types of exposures included butchering (20%), contact with raw meat (46.7%), and live animals (33.3%). Malignant pustule was present in upper extremity, both extremities, face, and trunk at frequencies of 11 (73.3%), 2 (13.3%), 1 (6.7%) and 1 (6.7%) respectively. Eight (53.3%) patients presented with fever, 7 (46.7%) had localized oedema and 5 (33.3%) had regional lymphadenopathy. Anthrax was confirmed in 13 (86.7%) cases by demonstration of gram-positive rods. All cases were cured with 2?months oral ciprofloxacin combined with flucoxacillin for 2?weeks. Conclusions We present the findings from this series of cases to reinforce the criteria for clinical diagnosis and to urge prompt therapeutic measures to treat cutaneous anthrax successfully to eliminate the unnecessary panic of anthrax. PMID:22929128

2012-01-01

56

Evaluation of Serum Levels of HER2, MMP-9, Nitric Oxide, and Total Antioxidant Capacity in Egyptian Breast Cancer Patients: Correlation with Clinico-Pathological Parameters.  

PubMed

Breast cancer is by far the most common cancer in women worldwide and the main cause of cancer-related mortality. Breast cancer accounts for 38% of all malignancies among Egyptian women. The aim of our study was to evaluate the serum levels of human epidermal growth factor receptor-2 (HER2), matrix metalloproteinase-9 (MMP-9), nitric oxide (NO), and total antioxidant capacity (TAC) in breast cancer patients and to correlate these markers with clinico-pathological parameters. Serum HER2, MMP-9, and carcinoma antigen 15-3 (CA 15-3) were assessed in 80 breast cancer patients and ten healthy subjects as a control group by the enzyme-linked immunosorbent assay (ELISA) technique while NO and TAC were assessed by a colorimetric method. Serum HER2 was ?15 ng/mL in nine patients (11.3%). High HER2 ECD levels were significantly associated with tissue HER2 (P<0.0001), metastasis (P= 0.0024), and negativity of both estrogen (P=0.0075) and progesterone (P=0.0239) receptors. Serum MMP-9 (P=0.0013), NO (P<0.0001), and CA 15-3 (P<0.0001) were significantly increased while serum TAC was significantly (P=0.01) decreased in breast cancer patients as compared to the control group. Serum MMP-9 was increased significantly (P=0.028) in metastatic patients as compared to non-metastatic patients. We found a positive correlation between serum HER2 and CA 15-3 (r=36, p=0.005). In conclusion, serum HER2 reflects the tissue HER2 status of breast cancer, so the determination of serum HER2 is helpful in assessing HER2 status, but in addition, a high level may reflect metastatic disease. Also, serum MMP-9 can be useful for denoting the development of metastasis in breast cancer patients. Follow-up is needed to evaluate the value of serum HER2 and MMP-9 as prognostic markers. PMID:24634847

Rashad, Yara A; Elkhodary, Tawfik R; El-Gayar, Amal M; Eissa, Laila A

2014-03-01

57

Galaxias australes con núcleo doble  

NASA Astrophysics Data System (ADS)

Se estudia una muestra de galaxias australes con núcleo doble a partir de una búsqueda extensiva en la literatura. Se analizan las características morfológicas, fotométricas y espectroscópicas de la muestra. Para algunas galaxias se han realizado observaciones con el espectrógrafo multifunción (EMF) de la Estación Astrofísica de Bosque Alegre a partir de las cuales se determinaron parámetros cinemáticos.

Gimeno, G.; Díaz, R.; Carranza, G.

58

Planificación Neuroquirúrgica con Software Osirix  

PubMed Central

Introducción: La individualidad anatómica es clave para reducir el trauma quirúrgico y obtener un mejor resultado. Actualmente, el avance en las neuroimágenes ha permitido objetivar esa individualidad anatómica, permitiendo planificar la intervención quirúrgica. Con este objetivo, presentamos nuestra experiencia con el software Osirix. Descripción de la técnica: Se presentan 3 casos ejemplificadores de 40 realizados. Caso 1: Paciente con meningioma de la convexidad parasagital izquierda en área premotora; Caso 2: Paciente con macroadenoma hipofisario, operada previamente por vía transeptoesfenoidal en otra institución con una resección parcial; Caso 3: Paciente con lesiones en pedúnculo cerebeloso medio bilateral. Se realizó la planificación prequirúrgica con el software OsiriX, fusionando y reconstruyendo en 3D las imágenes de TC e IRM, para analizar relaciones anatómicas, medir distancias, coordenadas y trayectorias, entre otras funciones. Discusión: El software OsiriX de acceso libre y gratuito permite al cirujano, mediante la fusión y reconstrucción en 3D de imágenes, analizar la anatomía individual del paciente y planificar de forma rápida, simple, segura y económica cirugías de alta complejidad. En el Caso 1 se pudo analizar las relaciones del tumor con las estructuras adyacentes para minimizar el abordaje. En el Caso 2 permitió comprender la anatomía post-operatoria previa del paciente, para determinar la trayectoria del abordaje transnasal endoscópico y la necesidad de ampliar su exposición, logrando la resección tumoral completa. En el Caso 3 permitió obtener las coordenadas estereotáxicas y trayectoria de una lesión sin representación tomográfica. Conclusión: En casos de no contar con costosos sistemas de neuronavegación o estereotáxia el software OsiriX es una alternativa a la hora de planificar la cirugía, con el objetivo de disminuir el trauma y la morbilidad operatoria. PMID:25165617

Jaimovich, Sebastián Gastón; Guevara, Martin; Pampin, Sergio; Jaimovich, Roberto; Gardella, Javier Luis

2014-01-01

59

Jugando con geometría: Crear secuencias con formas y palabras  

NSDL National Science Digital Library

En esta actividad, los chicos crean secuencias con palabras y formas. Los chicos usan colecciones de triángulos, cuadrados, y rectángulos con palabras adentro. Los chicos organizan las forman en secuencias geométricas que se repiten o que cambian de manera sistemática en cada línea. Los chicos más jóvenes pueden crear secuencias simples; los mayores pueden explorar secuencias que crecen de diferentes maneras. Esta actividad tiene colecciones de palabras en tres niveles de dificultad diferente. Disponible en formato Web y PDF. También disponible en Inglés.

TERC

2012-06-26

60

Compatibilidad con audfonos para sordos  

E-print Network

Compatibilidad con audífonos para sordos Hearing Aid Compatibility Q&A Q. What does hearing aid the different features of the phone thoroughly and in different locations, using your hearing aid or cochlear implant, to determine if you hear any interfering noise. Consult a sales representative about phone return

Greenberg, Albert

61

todasuvida: Las personas con diabetes son ms  

E-print Network

diabetes Controlesu todasuvida: Las personas con diabetes son más propensas a padecer de enfermedades del corazón que quienes no tienen diabetes. Boletín 631 D Las personas con diabetes tienen mayor- res relacionados con la diabetes, como derrame cerebral, mala circulación en las piernas y pies e

62

Generación de Electricidad con Energías Renovables (ER)  

Microsoft Academic Search

Los funcionarios argumentaron, entre otros, sobre la sostenibilidad energética a largo plazo, la producción de electricidad con Energías Renovables-ER (biomasa, eólico, solar, geotérmico, mareomotriz, e hidráulica con capacidad menor de 20 MW), la contaminación ambiental y las externalidades que produce, y las iniciativas sobre el uso de ER que han adoptado países mas adelantados como Alemania y España. El Vice-Ministro

Jaime E. Luyo

2008-01-01

63

ORNL/CON-462 Methodology for  

E-print Network

ORNL/CON-462 Methodology for the Evaluation of a 4000-Home Geothermal Heat Pump Retrofit at Fort agency thereof. #12;ORNL/CON-462 Methodology for the Evaluation of a 4000-Home Geothermal Heat Pump of the Fort Polk bid documents and the resultant performance contract between the Army and Co-Energy Group

Oak Ridge National Laboratory

64

AwareCon: Situation Aware Context Communication  

Microsoft Academic Search

Ubicomp environments impose tough constraints on networks, including immediate communication, low energy consumption, minimal maintenance and ad- ministration. With the AwareCon network, we address these challenges by prescribing an integrated architecture that differs from classical networking by featuring an aware- ness of the surrounding situation and context. In various settings, where AwareCon was implemented on tiny battery driven devices, we

Michael Beigl; Albert Krohn; Tobias Zimmer; Christian Decker; Philip Robinson

2003-01-01

65

Identification of resistance of Plasmodium falciparum to artesunate-mefloquine combination in an area along the Thai-Myanmar border: integration of clinico-parasitological response, systemic drug exposure, and in vitro parasite sensitivity  

PubMed Central

Background A markedly high failure rate of three-day artesunate-mefloquine was observed in the area along the Thai-Myanmar border. Methods Identification of Plasmodium falciparum isolates with intrinsic resistance to each component of the artesunate-mefloquine combination was analysed with integrated information on clinico-parasitological response, together with systemic drug exposure (area under blood/plasma concentration-time curves (AUC)) of dihydroartemisinin and mefloquine, and in vitro sensitivity of P. falciparum in a total of 17 out of 29 P. falciparum isolates from patients with acute uncomplicated falciparum malaria. Analysis of the contribution of in vitro parasite sensitivity and systemic drug exposure and relationship with pfmdr1 copy number in the group with sensitive response was performed in 21 of 69 cases. Results Identification of resistance and/or reduced intrinsic parasitocidal activity of artesunate and/or mefloquine without pharmacokinetic or other host-related factors were confirmed in six cases: one with reduced sensitivity to artesunate alone, two with resistance to mefloquine alone, and three with reduced sensitivity to artesunate combined with resistance to mefloquine. Resistance and/or reduced intrinsic parasitocidal activity of mefloquine/artesunate, together with contribution of pharmacokinetic factor of mefloquine and/or artesunate were identified in seven cases: two with resistance to mefloquine alone, and five with resistance to mefloquine combined with reduced sensitivity to artesunate. Pharmacokinetic factor alone contributed to recrudescence in three cases, all of which had inadequate whole blood mefloquine levels (AUC0-7days). Other host-related factors contributed to recrudescence in one case. Amplification of pfmdr1 (increasing of pfmdr1 copy number) is a related molecular marker of artesunate-mefloquine resistance and seems to be a suitable molecular marker to predict occurrence of recrudescence. Conclusions Despite the evidence of a low level of a decline in sensitivity of P. falciparum isolates to artemisinins in areas along the Thai-Myanmar border, artemisinin-based combination therapy (ACT) would be expected to remain the key anti-malarial drug for treatment of multidrug resistance P. falciparum. Continued monitoring and active surveillance of clinical efficacy of ACT, including identification of true artemisinin resistant parasites, is required for appropriate implementation of malaria control policy in this area. PMID:23898808

2013-01-01

66

DIVERSAS MANERAS DE GENERAR ENERGIA CON  

E-print Network

DE OLAS #12;PAISES CON MAYOR CAPACIDAD HIDROELECTRICA Country Annual Hydroelectric Energy Production hydroelectric generating system. Three Gorges Dam Gezhouba Dam #12;COSTO PROMEDIO DE PRODUCCION (KWH) #12;U

Gilbes, Fernando

67

Trastorno por déficit de atención con hiperactividad: comorbilidad con trastornos depresivos y de ansiedad  

Microsoft Academic Search

El estudio analiza el perfil comórbido del Trastorno por Déficit de Atención con Hiperactividad (TDAH) y trastornos depresivos y\\/o de ansiedad (TI), explorando el modelo que predice esta asocia- ción psicopatológica. Se analiza una muestra de 90 casos con TDAH (6-16 años) y mediante investi- gación diferencial se compara la agrupación TDAH+TI con la ausencia de esta comorbilidad. El caso

José Antonio López-Villalobos; Isabel Serrano Pintado; Juan Delgado Sánchez-Mateos

2004-01-01

68

Ependimoma myxopapilar sacro gigante con osteolisis  

PubMed Central

Objetivo: la presentación de un caso de una paciente con un ependimoma sacro con extensa infiltración y destrucción ósea local. Descripción del caso: una mujer de 53 años acudió a la consulta por dolor lumbosacro y alteraciones sensitivas perineales y esfinterianas. La imágenes por Resonancia Magnética (IRM) y la Tomografía Axial Computada (TAC) mostraron una lesión expansiva gigante a nivel S2-S4 con extensa osteólisis e invasión de tejidos adyacentes. Se realizó una exéresis tumoral completa con mejoría del estatus funcional. La anatomía patológica informó ependimoma mixopapilar. Discusión: la extensión de la resección quirúrgica es el mejor predictor de buen pronóstico. El tratamiento radiante se reserva como opción adyuvante para las resecciones incompletas y recidiva tumoral. La quimioterapia sólo debería utilizarse en casos en que la cirugía y la radioterapia estén contraindicadas. Conclusión: Los ependimomas mixopapilares sacros con destrucción ósea y presentación intra y extradural son muy infrecuentes y deben ser tenidos en cuenta entre los diagnósticos diferenciales preoperatorios. Su resección total, siempre que sea posible, es la mejor alternativa terapéutica. PMID:25165615

Ajler, Pablo; Landriel, Federico; Goldschmidt, Ezequiel; Campero, Álvaro; Yampolsky, Claudio

2014-01-01

69

Opciones de cirugía para mujeres con CDIS o con cáncer de seno  

Cancer.gov

Contiene información sobre los tipos de cirugía de seno, como la operación para conservar el seno y la mastectomía, y ayuda a las mujeres diagnosticadas con CDIS o con cáncer de seno a decidir cuál cirugía es la más conveniente para ellas.

70

Aleaciones con memoria de forma, una filosofía diferente en la ingeniería y el diseño con materias  

Microsoft Academic Search

Los materiales con memoria de forma también llamados materiales inteligentes poseen propiedades que los diferencian del resto de materiales. Estas propiedades no son propiedades mejoradas respecto a los materiales convencionales, sino que son nuevas propiedades que hacen que el proceso de diseño con materiales haya de ser modificado. La comprensión de estas nuevas propiedades y la estandarización de todos los

Fco. Javier Peña Andrés

2002-01-01

71

The iCons Four Year Curriculum Plan Contact: iCons@cns.umass.edu  

E-print Network

program offered by the College of Natural Sciences at the University their evolution in the iCons Program. Students' reflections in their portfolios) YEAR 1 (Spring 2013) iCons-1 (4 CR) 1 section: Tues/Thurs "Global Challenges

Auerbach, Scott M.

72

DIVERSAS MANERAS DE GENERAR ENERGIA CON  

E-print Network

;PAISES CON MAYOR CAPACIDAD HIDROELECTRICA Country Annual Hydroelectric Energy Production (TW-Rivera #12;The Three Gorges Dam project in Hubei, China, is the world's largest hydroelectric generating convirtio en la fuente principal de energia en Puerto Rico #12;23/feb/2008 Wave Power Energía de las Olas

Gilbes, Fernando

73

Equivariant con guration spaces Colin Rourke  

E-print Network

by thinking of the con guration as a set of charged particles and using the electric eld they generate (see 8(X) is a nite disjoint collection of little discs in M which is closed under the action of G and such that each

Rourke, Colin

74

Google Scholar: the pros and the cons  

Microsoft Academic Search

Purpose – To identify the pros and the cons of Google Scholar. Design\\/methodology\\/approach – Chronicles the recent history of the Google Scholar search engine from its inception in November 2004 and critiques it with regard to its merits and demerits. Findings – Feels that there are massive content omissions presently but that, with future changes in its structure, Google Scholar

Péter Jacsó

2005-01-01

75

Interacción, Motivación y Emociones con Videojuegos  

Microsoft Academic Search

El principal objetivo de este trabajo es comprender como se construye el conocimiento y se adquieren competencias en una comunidad virtual de aprendizaje soportada en una plataforma telemática integrada con un juego 3D de rol masivo. Para ello, hemos diseñado actividades formativas colaborativas que nos permitirán modelar las interacciones de una comunidad de aprendizaje virtual producidas en juegos de rol

Carina S. González; Francisco Blanco

76

The Pros and Cons of Artificial Reefs  

NSDL National Science Digital Library

This lesson plan asks students to consider whether artificial reefs (human-made objects in the ocean or sea) are good for marine ecosystems. Students will look at pictures of artificial reefs and read articles describing the pros and cons of these structures. They will conclude by writing paragraphs explaining whether they think a new artificial reef should be created in Florida waters.

77

Interacción con Entornos Virtuales en teléfonos móviles  

Microsoft Academic Search

En este trabajo presentamos un sistema para la navegación en entornos virtuales 3D sobre teléfonos móviles. Tradicionalmente la interacción con el teléfono móvil se ha realizado utilizando el teclado como dispositivo de interacción. Sin embargo, gracias a las capacidades de los nuevos terminales es posible aprovechar dispositivos como la cámara incorporada o los acelerómetros para implementar interacciones basadas en movimientos

Jesús Gimeno; Marcos Fernández; Pedro Morillo; Lucía Vera

78

The pros and cons of hospital employment.  

PubMed

The pros and cons of hospital employment vary significantly in today's economic environment. This chapter summarizes the advantages and disadvantages of hospital employment with an emphasis on the critical aspect of formalizing an agreement with the hospital employer to prevent future salary reductions and/or termination. PMID:23924751

Bert, Jack M

2013-09-01

79

Descubre la biblioteca con Gua rpida  

E-print Network

provenientes de los recursos electrónicos y del repositorio institucional #12;Acceso desde la página web de la, revistas, audiovisuales, mapas, ... Repositorio UAM: tesis doctorales, proyectos de investigación, revistas Repositorio · Algunas suscripciones a recursos electrónicos #12;Enlace con el documento Acceso mediante el

Autonoma de Madrid, Universidad

80

Clinico-Histologic Conferences: Histology and Disease  

ERIC Educational Resources Information Center

Providing a context for learning information and requiring learners to teach specific content has been demonstrated to enhance knowledge retention. To enhance students' appreciation of the role of science and specifically histology in clinical reasoning, disease diagnosis, and treatment, a new teaching format was created to provide clinical…

Shaw, Phyllis A.; Friedman, Erica S.

2012-01-01

81

[Congenital hydrocephalus: clinico-pathological picture].  

PubMed

The authors review the main pathologic causes of congenital hydrocephalus from ischemic-vascular injuries, embryofoetal infections and dysraphisms to genetic ones. Abundant illustrations of each condition are furnished and particular attention is paid to each situation, discussing the available pathogenetic mechanisms and hypothesis. Genetic "sine causa" hydrocephalus and X-linked hydrocephalus are mainly stressed, presenting some personal data. The clinic aspects of the varying forms of hydrocephalus are continuously kept in mind and a terminal paragraph details the clinical and neuroradiological means determinant in differential diagnosis versus similar conditions such as hydranencephaly, porencephaly, aracnoid cysts, holoprosencephaly and agenesis of corpus callosum. PMID:6100512

Della Giustina, E; Pace, P; Lugli, N; Botticelli, A R

1982-01-01

82

[Clinico-pathological collations in borreliosis].  

PubMed

Borreliosis is an infectious disease caused by spirochetal microorganisms Borrelia burgdorferi transmitted by ticks. Due to versatile clinical symptomatology and many pathogenetic aspects not explained yet, diagnosis of this disease is often very difficult. Borreliosis may affect various human organs and systems such as movement system, nervous system (central and peripheral), skin, heart and vessels. One of the diagnostic methods for detection of microbial organisms in tissues is the histochemical staining by Warthin-Starry. Very important problem connected with this illness is the relationship between borrelial antigens and autoimmunity. PMID:17007281

Wagner, Teresa; Legatowicz-Koprowska, Marta; Prochorec-Sobieszek, Monika

2006-06-01

83

Aggressive periodontitis: A clinico-hematological appraisal  

PubMed Central

Background: Human leukocyte antigens (HLA) have been considered a candidate of genetic risk markers for aggressive periodontitis (AP). AP has also been associated with polymorphonuclear leukocyte (PMN) dysfunction. The role of monocyte subsets in AP has also not been completely explored. Therefore, the present study was undertaken to assess in, AP subjects, the possible association between defective PMN adhesion and ?2-integrin expression; defective neutrophil migration and actin polymerization level; the expression of ABO blood group and HLA antigen; and the percentage of CD14+ CD16+ monocytes and CD45RA monocytes. All these parameters have been compared with the subjects of chronic periodontitis (CP) and healthy controls. Materials and Methods: A total of 45 subjects of the age group 20-50 years, free from any known systemic disease, were divided into three groups – Group I - periodontally healthy control (n = 15), Group II - CP (n = 15) and Group III - AP (n = 15). Peripheral blood samples were collected. ABO grouping and HLA typing were performed. ?2-integrin expression, actin polymerization level and percentage of CD14+ CD16+ monocytes and CD45RA monocytes were estimated by fluorescence-activated cell sorter analysis. Results: Most of the subjects of AP belonged to the blood group AB, and an increased frequency of HLA-A30, CW1 and DR1 (P < 0.1) and B44 and DQ2 (P < 0.05) were also observed in this group. In the AP group, both average values (?2-integrin and actin level) were significantly less than those of normal subjects (P < 0.001). The mean percentage of CD14+ CD16+ monocytes was found to be maximum in CP, followed by AP, and then in healthy subjects, while the mean percentage of CD45RA was maximum in AP, followed by CP, and then in healthy subjects. Conclusions: With the present state of knowledge from this study, a definite association of ABO blood groups and HLA phenotypes with periodontal diseases is yet to be established. Leukocytic functional defects were found in AP subjects. A statistically significant percentage of CD14+ CD16+ and CD45RA monocytes were found in AP subjects as compared with the normal control and CP groups. PMID:24872623

Kundu, Debabrata; Bandyopadhyay, Prasanta; Nair, Vineet; Chowdhury, Mona; Mukherjee, Saswati; Nayek, Moumita

2014-01-01

84

VANET Routing Protocols: Pros and Cons  

E-print Network

VANET (Vehicular Ad-hoc Network) is a new technology which has taken enormous attention in the recent years. Due to rapid topology changing and frequent disconnection makes it difficult to design an efficient routing protocol for routing data among vehicles, called V2V or vehicle to vehicle communication and vehicle to road side infrastructure, called V2I. The existing routing protocols for VANET are not efficient to meet every traffic scenarios. Thus design of an efficient routing protocol has taken significant attention. So, it is very necessary to identify the pros and cons of routing protocols which can be used for further improvement or development of any new routing protocol. This paper presents the pros and cons of VANET routing protocols for inter vehicle communication.

Paul, Bijan; Bikas, Md Abu Naser

2012-01-01

85

Aspectos relacionados con la sexualidad y la reproducción (PDQ®)  

Cancer.gov

Resumen de información revisada por expertos acerca de los factores que podrían afectar el funcionamiento sexual de las personas con cáncer. Se discuten además temás sobre la fertilidad relacionados con el tratamiento del cáncer.

86

Aspectos relacionados con la sexualidad y la reproducción (PDQ®)  

Cancer.gov

Resumen de información revisada por expertos acerca de los factores que pueden afectar el funcionamiento sexual de las personas con cáncer. Se discuten además temas sobre la fecundidad relacionados con el tratamiento del cáncer.

87

Experimental and Computational Studies of Carbonyl Diazide (CON6) as a Precursor to Diazirinone (CON2)  

NASA Astrophysics Data System (ADS)

Intrigued by the reported 2005 synthesis of diazirinone (1), we carried out further experimental and theoretical studies aimed at the detailed matrix-isolation and millimeter-wave spectroscopic characterizations of 1. Diazirinone (1) is a peculiar isoconjugate of two very stable molecules and may be of astrochemical interest. Unfortunately, the original reported methods of diazirinone (1) generation did not yield this species, rather its decomposition products. Inspired by a more recent gas phase pyrolysis of CON6 (2) to yield CON2 (1), we proposed a new method of generating CON6 (2) in solution as a precursor of diazirinone (1). This new synthesis may allow us to generate larger quantities of both CON6 and CON2 for investigation by millimeter-wave spectroscopy. We are able to safely generate carbonyl diazide (2) in sufficient yield from the reaction of triphosgene (3) and tetrabutylammonium azide in diethyl ether. This has allowed us to obtain both matrix-isolation and gas phase IR spectra of carbonyl diazide (2). After purification, it has a gas-phase lifetime that allows samples to be useable for up to several weeks. However, it is a shock-sensitive material that must be handled with care to prevent violent decomposition. In order to provide better mechanistic insight into the decomposition of carbonyl diazide (2) to diazirinone (1), we have engaged in a DFT and ab initio computational study. We have found a pathway between the two species via the triplet acylnitrene, CON4, and an oxaziridine CON2 species, but not at sufficiently low energies to allow for the trapping and detection of diazirinone (1). Preliminary millimeter-wave spectra have been obtained from several synthesized and purified samples of CON6 (2). However, the assignment of the spectra lines has been unexpectedly problematic. We have placed several CON6 (2) samples, confirmed by IR spectroscopy at the time of sample loading, into our instrument and obtained two different sets of rotational lines. This rotational puzzle will be investigated further with a significantly upgraded millimeter-wave spectrometer.

Esselman, Brian J.; Amberger, Brent K.; Nolan, Alex M.; Woods, R. Claude; McMahon, R. J.

2011-10-01

88

Tiene familiares con Alzheimer? La Escuela de Medicina del Recinto de Ciencias Mdicas en colaboracin con la Universidad de Columbia  

E-print Network

¿Tiene familiares con Alzheimer? 25/1/2008 La Escuela de Medicina del Recinto de Ciencias Médicas más con Alzheimer para participar de un estudio genético. La investigación pretende encontrar genes que se encuentren relacionados a la enfermedad de Alzheimer con el propósito de aprender más sobre las

Quirk, Gregory J.

89

Energy Star program benefits Con Edison  

SciTech Connect

Impressed with savings in energy costs achieved after upgrading the lighting and air conditioning systems at its Manhattan headquarters, Home Box Office (HBO) wanted to do more, James Flock, vice president for computer and office systems, contacted Con Edison Co. of New York in March 1991 to determine what the company could do to save money by reducing energy consumed by personal computers. Arthur Kressner, Con Edison Research and Development manager contacted industry organizations and manufacturers for advice, but was told only to shut off computers at night and on weekends. Kressner arranged a series of meetings with IBM and the Electric Power Research Institute (EPRI) to discuss the issue, then approached the U.S. Environmental Protection Agency (EPA), which was designing a program to promote the introduction and use of energy-efficient office equipment. In 1992, the EPA announced the Energy Star program for PCs, enabling manufacturers to display the Energy Star logo on machines meeting program criteria, including the ability to enter a sleep mode in which neither the computer nor monitor consume more than 30 W or electricity. Industry experts estimate national energy consumption by office equipment could double by the year 2000, but Energy Star equipment is expected to improve efficiency and help maintain electric loads.

NONE

1995-05-01

90

Web Spoofing: An Internet Con Game  

NSDL National Science Digital Library

The Safe Internet Programming group at the Princeton University Department of Computer Science in 1996 published a paper on the practice known as "web spoofing," through which an attacker intervenes between an end-user browsing the Web and real Web sites. The attacker sets up a shadow copy of the Web, and as users request pages from sites they will receive pages from the attacker's site instead. This process also enables attackers to gather data (possibly credit card numbers, etc.) submitted through bogus web forms. The nine-page paper describes how the con game works and suggests remedies. The article is available in PostScript, compressed PostScript, Microsoft Word, and zipped Microsoft Word format. Unfortunately, it is not available online as HTML.

Balfanz, Dirk .

1996-01-01

91

Habilidades matemáticas y funcionamiento ejecutivo de niños con trastorno por déficit de atención con hiperactividad y dificultades del aprendizaje de las matemáticas  

Microsoft Academic Search

A pesar de que un 26% de niños con TDAH tiene una dificultad específica en el aprendizaje de las ma- temáticas (DAM) las investigaciones han sido escasas. El presente estudio se planteó estudiar: 1) el perfil de los niños con TDAH+DAM en habilidades cognitivas y metacognitivas de cálculo y solución de problemas, en comparación con niños con TDAH, niños con

Ana Miranda Casas; Amanda Meliá de Alba; Rafaela Marco Taverner

2009-01-01

92

if l = nil then m := cons(a, nil);  

E-print Network

if l = nil then m := nil; else begin a := l.1; m := cons(a, nil); i := l.2; j := m; while i = nil do begin a := i.1; t := cons(a,nil); j.2 := t; i := i.2; j := t; end end 1 #12;{l nil} if l = nil then m := nil; else begin a := l.1; m := cons(a, nil); i := l.2; j := m; while i = nil do begin a := i.1

Reddy, Uday S.

93

Clave de determinacin de los Heliconiinae con rayas anaranjadas  

E-print Network

: mathieu.joron@ed.ac.uk 1. a. Abdomen con puntos amarillos y gruesos en los costados (intrasegmentales..............................................................................2 2. a. Abdomen con anillos intersegmentales amarillos........................Heliconius xanthocles relativamente pequeña, abdomen no muy largo. Ciertas razas no tienen color anaranjado en la cara dorsal

Joron, Mathieu

94

Breath Analysis Science at PittCon 2012, Orlando, Florida  

EPA Science Inventory

Breath analysis science was featured in three organized sessions at this year?s Pittsburgh Conference and Exposition, or ?PittCon 2012? (http://www.pittcon.org/). As described in previous meeting reports, PittCon is one of the largest international conferences for analytical chem...

95

RoboCon: A general purpose telerobotic control center  

SciTech Connect

This report describes human factors issues involved in the design of RoboCon, a multi-purpose control center for use in US Department of Energy remote handling applications. RoboCon is intended to be a flexible, modular control center capable of supporting a wide variety of robotic devices.

Draper, J.V.; Noakes, M.W. [Oak Ridge National Lab., TN (United States). Robotics and Process Systems Div.; Schempf, H. [Carnegie Mellon Univ., Pittsburgh, PA (United States); Blair, L.M. [Human Machine Interfaces, Inc., Knoxville, TN (United States)

1997-02-01

96

Introduzione alla programmazione client-side (con Javascript)  

E-print Network

1 MODULO 2 PARTE 4 Introduzione alla programmazione client-side (con Javascript) Goy - a.a. 2010/2011 Programmazione Web client side (con Javascript) 1 · Javascript è un linguaggio di scripting, tipicamente Javascript · Come tutti i linguaggi di scripting, è interpretato: il sorgente non deve essere compilato per

Goy, Anna

97

Introduzione alla programmazione client-side (con Javascript)  

E-print Network

1 MODULO 2 PARTE 4 Introduzione alla programmazione client-side (con Javascript) Goy - a.a. 2009/2010 Programmazione Web client side (con Javascript) 1 · Javascript è un linguaggio di scripting, tipicamente Javascript · Come tutti i linguaggi di scripting, è interpretato: il sorgente non deve essere compilato per

Goy, Anna

98

Introduzione alla programmazione client-side (con Javascript)  

E-print Network

1 MODULO 2 PARTE 4 Introduzione alla programmazione client-side (con Javascript) Goy - a.a. 2012/2013 Programmazione Web client side (con Javascript) 1 Il fil rouge del MODULO 2 PARTE 4: Introduzione alla progr. client-side · Javascript · DOM e gestori di eventigli oggetti del DOM... PARTE 5: Programmare sul Web 2

Goy, Anna

99

Introduzione alla programmazione client-side (con Javascript)  

E-print Network

1 MODULO 2 PARTE 4 Introduzione alla programmazione client-side (con Javascript) Goy - a.a. 2011/2012 Programmazione Web client side (con Javascript) 1 Il fil rouge del MODULO 2 PARTE 4: Introduzione alla progr. client-side · Javascript · DOM e gestori di eventigli oggetti del DOM... PARTE 5: Programmare sul Web 2

Goy, Anna

100

The 2009 Astrobiology Graduate Student Conference (AbGradCon)  

NASA Astrophysics Data System (ADS)

The 2009 AbGradCon was held at the University of Washington in July 2009. It brought together 67 participants from 8 different countries and 34 different universities. AbGradCon also took place in the virtual world of Second Life.

Som, S. M.; Anderson, R.; Antonio, M.; Cash, M. C.; Claire, M.; Cowan, N.; Ewert, M.; Goldman, A.; Snowden, D.; Stüeken, E.

2010-04-01

101

Control del dolor: Apoyo para las personas con cáncer  

Cancer.gov

Contiene información sobre las medicinas contra el dolor para pacientes con cáncer, los planes para controlarlo, cómo hablar con su equipo de atención médica sobre el dolor que usted siente y qué hacer para controlar los efectos físicos y emocionales del mismo.

102

Pro/con a precessional geodynamo  

NASA Astrophysics Data System (ADS)

The modest amount of research that exists on the ability, or lack of ability, of mantle precession to power a geodynamo developed mostly during the last half of the 1900s. Papers by Roberts and Stewartson (1965) and by Busse (1968) studied precession generally without a pro/con conclusion. Malkus in the late 1960s attempted to advance a positive role for precession through experiments and analysis. His experiments have survived criticism, but his analyses were discounted, especially by Rochester, Jacobs, Smylie, and Chong (1975) and by Loper (1975). Rochester, et al. critiqued existing analyses of precession, including those of Malkus, but did not reach a strong position either pro or con a precessional geodynamo. Loper argued emphatically that precession was not capable of powering the geodynamo. Explicit analyses that either critique or support Loper’s arguments have yet to appear in the literature. During the 1970s, Vanyo and associates studied energy dissipation during precession of satellite liquid fuels and its effect on satellite attitude stability. Engineers and scientists in every country that has launched satellites completed similar research. Some is published in the aerospace literature, more is available in company and government reports. Beginning in 1981, Vanyo and associates applied this knowledge to the very similar problem of energy dissipation and flow patterns in precessing mechanical models scaled geometrically and dynamically to the Earth’s liquid core. Energy experiments indicate massive amounts of mechanical energy are dissipated at the CMB, and flow experiments show complex motions within the boundary layer and axial flows with helicity throughout the interior. Analysis of Earth core precession also advanced, especially in several papers by Kerswell and by Tilgner in the late 1990s. Detail numerical models have yet to appear. Although progress in understanding the role of precession in Earth core motions has advanced, there remains a common belief, often expressed explicitly, that precession is incapable of energizing a geodynamo, a la Loper. We will present a critique of Loper’s 1975 paper and briefly discuss the common practice and belief that the geodynamo must be energized by thermal and/or compositional driven convection (motion). We note here that there is no observational evidence for existence of thermal or compositional convection within the liquid core or for growth of the solid core. Although there has been considerable success in adapting data in thermal/compositional models to yield near realistic solutions, that does not constitute a proof that those models apply to the Earth. There is absolute observational evidence for mantle precession, an Earth feature that is unique, along with the Earth’s magnetic field, among the terrestrial planets. We argue that great difficulty experienced in analysis and computation of precessional flow is a major explanation for its absence in current models of the geodynamo.

Vanyo, J.

2003-04-01

103

Cálculos ab initio con correlación electrónica  

NASA Astrophysics Data System (ADS)

Estamos entrando en una era donde la ortogonalidad entre las investigaciones de carácter experimental y de naturaleza teórica se irá difuminando progresivamente y la problemática a resolver quedará en escena como el único actor principal de la obra. Como premisa para una cooperación teórico-experimental de igual a igual, la metodología químico-cuántica utilizada debe ser capaz de ofrecer resultados de carácter predictivo. Sin duda, esta madurez en la metodología químico-cuántica ya la hemos alcanzado hace algunos años, tal y como muestra entre otras muchas, la labor que nuestro grupo ha realizado en el transcurso de la última década, dentro del campo de la Espectroscopía Teórica. Los estudios realizados comprenden una amplia gama de sistemas, variando tanto en tamaño como en complejidad, abordando problemáticas espectroscópicas consideradas tradicionalmente como especialmente controvertidas. Nuestra contribución científica más relevante reside en el carácter cuantitativo de las asignaciones espectroscópicas que hemos propuesto en base a resultados ab initio. Recordemos que en los años noventa los resultados ab initio solían presentar para las energías de excitación de sistemas de tamaño molecular moderado, como el benceno, errores de más de 1 eV. En comparación con el éxito relativo de los métodos semiempíricos, la frustración de la metodología ab initio quedaba todavía más patente. Los estudios que hemos presentado representan una comprensión profunda de los espectros electrónicos en sistemas orgánicos claves, mostrando el camino a seguir para obtener asignaciones espectroscópicas precisas (entre 0.1-0.2 eV). La naturaleza del método CASPT2 junto al diseño de estrategias computacionales nos ha permitido alcanzar el carácter cuantitativo con el que se caracterizan nuestras contribuciones[1,2]. Por todo ello, algunos de los trabajos publicados se consideran clásicos dentro del campo, pues en cierto modo definen el campo, y se reflejan en libros publicados recientemente. En la conferencia se analizarán ciertos pormenores de las investigaciones realizadas. El tipo de aplicaciones llevadas a cabo hasta la fecha se ilustrará mediante el estudio teórico del espectro electrónico de ciclooctatetraeno. Dando un paso más en la evolución de nuestra investigación, pretendemos en la actualidad describir, desde un formalismo teórico y al mismo nivel de exigencia, los mecanismos subyacentes que tienen lugar en las reacciones biológicas fototoinducidas, es decir, reacciones que se inician mediante la absorción de luz[3]. Como muestra de la caracterización de los procesos fotofísicos y fotoquímicos en fotobiología teórica, hemos elegido la descripción de la conversión interna ultrarrápida que tiene lugar en los cromóforos del ADN. Los estados excitados de las moléculas de los ácidos nucleicos presentan tiempos de vida media que se encuentran en el rango de sub-picosegundos, sugiriendo la presencia de un canal ultrarrápido de conversión interna, lo que normalmente se asocia en la fotoquímica contemporánea a una intersección cónica entre el estado excitado y el fundamental[4]. De esta forma nuestro ADN previene de forma eficaz posibles reacciones en el estado excitado y se revela como un excelente protector solar.

Merchán Bonete, M.

104

DESAFÍOS ÉTICOS DE LA INVESTIGACIÓN CON ANIMALES, MANIPULACIÓN GENÉTICA  

PubMed Central

En la investigación con animales existen cuestionamientos éticos tanto en el uso como modelos de enfermedades humanas y requisito previo para ensayos en humanos como en la introducción de modificaciones genéticas. Algunos de estos cuestionamientos son: no representar exactamente la condición humana como modelos, realizar pruebas de toxicidad con grave daño para los animales, alterar su naturaleza mediante modificaciones genéticas, riesgos de la introducción de organismos genéticamente modificados. El uso de animales en investigación para beneficio humano, impone al ser humano la responsabilidad moral de respetarlo, no haciéndoles sufrir innecesariamente, al estar trabajando con seres vivientes y sentientes. PMID:23338641

Yunta, Eduardo Rodríguez

2012-01-01

105

Utilidad diagnóstica del Cuestionario TDAH y del Perfil de Atención para discriminar entre niños con tratorno por déficit de atención con hiperactividad, trastornos del aprendizaje y controles  

Microsoft Academic Search

Se analiza la convergencia entre la información recogida de padres y profesores, mediante escalas de valoración, y el diagnóstico clínico en una muestra de 126 niños: 42 con Trastorno por déficit de atención con hiperactividad (TDAH) tipo combinado, 21 con Trastornos del aprendizaje (TA) y 63 controles, con edades comprendidas entre los 4 y los 12 años. El grupo de

Juan Antonio Amador; Maria Forns; Joan Guàrdia Olmos; Maribel Peró

2005-01-01

106

Control del dolor: Apoyo para las personas con cáncer  

Cancer.gov

Libro sobre el control del dolor en pacientes con cáncer. Cubre los métodos y medicinas, así como los efectos físicos y emocionales del dolor. Es una adaptación cultural para el público de habla hispana del libro en inglés Pain Control.

107

iCons, 2011 Alzheimers and Aluminum: Lesson Plan  

E-print Network

© iCons, 2011 Alzheimers and Aluminum: Lesson Plan Handouts to explore mechanistic link between Alzheimer's and aluminum 5. Brief proposal expanding Points to Aluminum's Link With Alzheimer's Disease" from 1989. Provide handout

Auerbach, Scott M.

108

Breath analysis science at PittCon 2012, Orlando, Florida  

Microsoft Academic Search

BackgroundBreath analysis science was featured in three organized sessions at this year's Pittsburgh Conference and Exposition, or 'PittCon 2012' (http:\\/\\/www.pittcon.org\\/). As described in previous meeting reports, PittCon is one of the largest international conferences for analytical chemistry and instrumentation, typically attracting about 20 000 attendees and 1000 commercial exhibitors (Pleil 2010, 2011). This year the conference was held in Orlando,

Joachim D Pleil; Matthew A Stiegel; Tzipporah M Kormos; Jon R Sobus

2012-01-01

109

Cómo hacer las gestiones con su plan de salud  

Cancer.gov

Hay formas de saber si su plan de salud cubre los costos de atención médica de rutina durante un estudio clínico. Esta información puede servirle para saber con quién comunicarse para solicitar ayuda, preguntas que puede hacer y la información que debe recoger y guardar si decide participar en un estudio clínico.

110

Redes Reconfigurables Controladas por Marcado: Redes de Petri con Cambios  

E-print Network

Redes Reconfigurables Controladas por Marcado: Redes de Petri con Cambios Din´amicos Estructurales a cambios din´amicos utilizando exten- siones de redes de Petri. En estudios previos, hemos introducido los siste- mas de reescritura de redes y una subclase de los mismos llamada redes reconfigurables. En un

Alpuente, María

111

con Diabetes Su diabetes s se puede controlar!  

E-print Network

Do Well, Be Well con Diabetes ¡Su diabetes sí se puede controlar! Educational programs of the Texas, and the County Commissioners Courts of Texas Cooperating. to develop diabetes self-care skills, to improve eating habits and maintain good nutrition, to increase physical activity, to prevent diabetes complications

112

Teaching after Retirement: The Pros and the Cons  

ERIC Educational Resources Information Center

Having enjoyed teaching during my active career, I continued to teach summer school following retirement. Self-observed sensory and cognitive impairments, although not mentioned by students in their evaluations, induced me to consider the pros and cons of continuing to teach. My hope is that this list of benefits and problems will be of assistance…

Sommer, Robert

2014-01-01

113

Applying Manure to Alfalfa Pros, Cons and Recommendations for  

E-print Network

Applying Manure to Alfalfa Pros, Cons and Recommendations for Three Application Strategies K and other Organic Wastes in Agriculture. It summarizes existing informa- tion on use of manure on alfalfa, Ohio #12;It's becoming increasingly common for livestock producers to apply manure to alfalfa

Balser, Teri C.

114

Portadores nasofaríngeos de Neisseria meningitidis en trabajadores con riesgo ocupacional  

Microsoft Academic Search

Los portadores de Neisseria meningitidis constituyen la principal fuente de infección y transmisión de la enfermedad meningocócica. Conocer su prevalencia, las características de las cepas aisladas y los factores de riesgos asociados con el estado de portador, aportan datos valiosos al control y vigilancia epidemiológica de esta entidad clínica. Para cumplimentar los objetivos propuestos se realizó un estudio transversal descriptivo

Isabel Martínez; Gustavo Sierra; Georgina Pardo; Niurka Álvarez; Marlene Armesto; Mayelín Mirabal

2010-01-01

115

FOTOPLETISMOGRAFÍA CON DIODOS LÁSER INFRARROJOS EN ÓRGANOS INTRAPERITONEALES DEL CERDO  

Microsoft Academic Search

1. Resumen. Entre las técnicas que se emplean para monitorizar órganos y tejidos se encuentran la fotopletismografía, la oximetría de pulso y la flujometría por efecto Doppler láser. Existen procesos que afectan a determinados órganos o territorios del organismo, sin repercusión significativa en el grado de oxigenación periférica, que no pueden ser monitorizados con los dispositivos disponibles actualmente. Resulta necesario

S. M. López Silva; J. P. Silveira Martín; L. Herrera; M. L. Dotor Castilla

116

In both climate states the changing oceanic heat con-  

E-print Network

of climate change. One driver of global weather patterns is the El Nino/La Nina cycle. El Nino refers warms. Dr. Curtis sees somewhat of a mixed signal using global satellite data sets. During both El NinoIn both climate states the changing oceanic heat con- tent affects the large scale atmospheric

117

In collaborazione con: CFA SOCIETY ITALY FUND MANAGEMENT CHALLENGE  

E-print Network

con le best-practices internazionali. Ogni squadra si impegna ad applicare il codice di deontologia professionale Code of Ethics and Standards of Professional Conduct promosso da CFA Institute, l CFA e CIPM. Il Code of Ethics and Standards of Professional Conduct, cui aderiscono tutti i membri CFA

Guidoni, Leonardo

118

Caracterización de tintas de titanio dopadas con óxidos metálicos  

Microsoft Academic Search

Se prepararon tintas de Diisopropoxido de titanio bis(acetilacetonato) por el método sol-gel para aplicar en la elaboración de nanoestructuras mediante la técnica de escritura directa. Esta técnica permite estructurar materiales con alto índice de refracción a escala micro y nanométrica en tres dimensiones mediante extrusión, para elaborar cristales fotónicos. El tratamiento de las nanoestructuras extruidas a temperaturas elevadas para transformarlas

C. R. TUBÍO; F. GUITIÁN; A. GIL

119

Some pros and cons of six sigma: an academic perspective  

Microsoft Academic Search

Six sigma is a powerful business strategy that employs a disciplined approach to tackle process variability using the application of statistical and non-statistical tools and techniques in a rigorous manner. This paper examines the pros and cons of six sigma in a detailed manner. This is followed by a section about the future of six sigma and its links to

Jiju Antony

2004-01-01

120

1. INTRODUCTION The MesoscaleAlpine Programme (MAP) was con-  

E-print Network

1. INTRODUCTION The MesoscaleAlpine Programme (MAP) was con- ducted over the European Alps the region, and moist air flows from the Mediterranean Sea toward the southern Alps. Dual-polarimetric Doppler and verti- cally pointing radar data collected during MAP on the Mediterranean side of the Alps

Houze Jr., Robert A.

121

The evolution of female mate choice by sexual con ict  

E-print Network

The evolution of female mate choice by sexual con ict Sergey Gavrilets1* , Go« ran Arnqvist2 sexual selection by female mate choice, our understanding of the adaptive value of female mating preferences is still very incomplete. It has recently been suggested that female mate choice may result from

Gavrilets, Sergey

122

Quantum computing: pro and con BY JOHN PRESKILL  

E-print Network

-tolerant procedures that enable a quantum computer with noisy gates to perform reliably. Quantum computing hardware will the quantum computers of the future use? Can this hardware be constructed via incremental improvementsQuantum computing: pro and con BY JOHN PRESKILL Charles C. Lauritsen Laboratory of High Energy

Preskill, John

123

Inclusion: The Pros and Cons--A Critical Review  

ERIC Educational Resources Information Center

The purpose of this paper was to review, analyze, and critique the pros and cons, the advantages and disadvantages, of inclusion. The methodology consisted in analyzing and comparing research findings on the benefits and costs of inclusion. Federal legislation and regulations on inclusion were examined, analyzed, and discussed. The results showed…

Savich, Carl

2008-01-01

124

NEWS & NOTES Jennifer Keeney's Trio Angelico will perform four con-  

E-print Network

NEWS & NOTES Jennifer Keeney's Trio Angelico will perform four con- certs December 1-9 in Japan- tion. Catherine Baker, Lindsay Fyffe, Sarah Giron, and Kasumi Nakashiima (studio of Jennifer Keeney) also participated. Antonia Rogers (studio of Jennifer Keeney and Krystal Grauvogl (studio of Timothy

Azevedo, Ricardo

125

-okfl ^ ORNL/CON-172 Linear Harmonic Analysis of Free-  

E-print Network

Stirling Engines N. C. J. Chen F. P. Griffin OPERATED BY MARTIN MARIETTA ENERGY SYSTEMS, INC. #12;ORNL/CON-172 Engineering Technology Division* LINEAR HARMONIC ANALYSIS OF FREE-PISTON STIRLING/dynamic problem that is associated with a free-piston Stirling engine (FPSE). The governing equations

Oak Ridge National Laboratory

126

Detail of conning tower atop the submarine. Note the wire ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Detail of conning tower atop the submarine. Note the wire rope wrapped around the base of the tower, which may have been used in an attempt to pull the submarine offshore. - Sub Marine Explorer, Located along the beach of Isla San Telmo, Pearl Islands, Isla San Telmo, Former Panama Canal Zone, CZ

127

performances, lectures, demonstra-tions, and workshops exploring con-  

E-print Network

promoted three major concerts in three different spaces. The opening event brought together the jazz of Frances Lynch, one of the few international singers to have worked closely with composers of electro- acoustic music. Her dramatic and most commited performances con- tinue to inspire many composers, not least

Miranda, Eduardo Reck

128

LunGradCon: The Lunar Graduate Conference  

NASA Astrophysics Data System (ADS)

Members of the Colorado Center for Lunar Dust and Atmospheric Studies (CCLDAS) initiated the Lunar Graduate Conference (LunGradCon), modeled after the highly successful Astrobiology Graduate Conference (AbGradCon). The purpose of this conference is to enhance the professional development of graduate students and early postdoctoral researchers by providing an opportunity to present and discuss scientific research in an environment of their peers. For the first two years, LunGradCon has been held as a one-day conference in conjunction with the NASA Lunar Science Institue's (NLSI) Lunar Science Forum at the NASA Ames Research Center. Activities include an invited overview talk on each of the NASA Lunar Science Institute's three main research areas (OF the Moon, ON the Moon, and FROM the Moon), submitted oral presentations from graduate students and postdoctoral researchers, and networking opportunities with established member of the lunar science community and the NLSI. In each of the first two years of LunGradCon, there have been 20-25 attendees, with about 15 of those presenting submitted talks. Each speaker received feedback forms from the other participants in order to improve on their presentation techniques. Participants also provided feedback on the conference as a whole in order to evaluate the content and provide suggestions for improvement in following years. Overall, the feedback has been extremely positive. This talk will summarize the achievements of past LunGradCons and plans for expansion of the conference to ensure a long-term positive impact on the early careers of future lunar, planetary and space science researchers.

Dove, A.; Poppe, A.; Neish, C.; Fagan, A.; Fuqua, H.; Kramer, G. Y.; Horanyi, M.

2011-12-01

129

CONTAMINACIÓN INDUSTRIAL CON SOLVENTES ORGÁNICOS COMO CAUSA DE TERATOGÉNESIS  

Microsoft Academic Search

Saavedra-Ontiveros D, Arteaga-Martínez M, Serrano-Medina B, Reynoso-Arizmendi F, Prada-Garay N, Cornejo-Roldán LR. Contaminación industrial con solventes orgánicos como causa de teratogénesis. Salud Publica Mex 1996;38:3-12. ABSTRACT Objective. To inform of a new teratogenic syndrome in human beings and its confirmation in rats. Material and Methods. The study comprised three phases: a field study; a case-control study; and a genetic epidemiology

DOLORES SAAVEDRA-ONTIVEROS; M. EN; MANUEL ARTEAGA-MARTÍNEZ; BEATRIZ SERRANO-MEDINA; FRANCISCO R EYNOSO-ARIZMENDI; NICOLÁS PRADA-GARAY; LAURA ROSA CORNEJO-ROLDÁN

130

The Pros and Cons of RFID in Supply Chain Management  

Microsoft Academic Search

This paper presents the pros and cons of using Radio-Frequency IDentification (RFID) in Supply Chain Management (SCM). While RFID has a greater number of benefits than its predecessor, the bar code, it currently comes at a price that many businesses still consider prohibitive. On the one hand, RFID is advantageous because it does not require line-of-sight scanning, it acts to

Katina Michael; Luke Mccathie

2005-01-01

131

French-Canadian translation of the WheelCon-M (WheelCon-M-F) and evaluation of its validity evidence using telephone administration.  

PubMed

Abstract Purpose: The objectives of this study were to: (1) translate the Wheelchair Use Confidence Scale for Manual Wheelchair Users (WheelCon-M) into a French-Canadian version (WheelCon-M-F); and (2) evaluate the WheelCon-M-F validity evidence based on response processes, internal structure, and relations with other variables. Methods: The WheelCon-M was translated from English to French using the Translation and Cultural Adaptation of Patient Reported Outcomes Measures - Principles of Good Practice guidelines. We used a test-retest design to examine the validity of the WheelCon-M-F with 24 community dwelling, experienced manual wheelchair users who had a variety of musculoskeletal and neurological diagnoses. Results: The mean?±?SD WheelCon-M-F score was 63.8?±?19.9. All WheelCon-M-F items were either identical or similar in meaning to the WheelCon-M items. Clarification issues were identified with 27/63 items. Cronbach's alpha was 0.98 and the retest intraclass correlation coefficient was 0.87. The standard error of measurement and smallest real difference were 7.2 and 19.9, respectively. There were no floor or ceiling effects. WheelCon-M-F correlations with social support and participation were r?=?0.54 and 0.78, respectively. Conclusions: The WheelCon-M-F is a valid outcome measure for assessing manual wheelchair confidence in the French-Canadian population. Implications for Rehabilitation The WheelCon-M-F is a valid outcome measure available for assessing wheelchair confidence, a modifiable barrier to wheelchair use. Translation of the WheelCon-M into the WheelCon-M-F allows collection of both clinical and research wheelchair confidence data using the two official Canadian languages, English and French. PMID:25039622

Rushton, Paula W; Routhier, François; Miller, William C; Auger, Claudine; Lavoie, Marie-Pier

2014-07-21

132

IZ-CON: an intelligent zone controller for building systems operation  

E-print Network

This paper describes the concept of an intelligent zone controller (IZ-CON) for integrated operation of building systems. IZ-CON is intended to deploy a predictive control methodology with embedded simulation capability. Thereby, the scalability...

Mahdavi, A.; Schub, M.

2012-01-01

133

A Feedback Controlled Stimulator That Delivers Con-trolled Displacements or Forces to Cutaneous  

E-print Network

66 A Feedback Controlled Stimulator That Delivers Con- trolled Displacements or Forces to Cutaneous as to be able to control force as well. The stimulator can be operated in the standard con- trolled displacement

Byrne, John H.

134

ESTUDIO OPINÁTICO DE LOS PACIENTES EN RELACIÓN CON LA ESCLEROSIS DE LAS VÁRICES QUIRÚRGICAS  

Microsoft Academic Search

quirúrgicas con solución esclerosante yodo-yodurada a concentraciones variables, mostrando quirúrgicas con solución esclerosante yodo-yodurada a concentraciones variables, mostrando quirúrgicas con solución esclerosante yodo-yodurada a concentraciones variables, mostrando quirúrgicas con solución esclerosante yodo-yodurada a concentraciones variables, mostrando preferencia por la escleroterapia y satisfacción al tratamiento sometido. Además consideramos preferencia por la escleroterapia y satisfacción al tratamiento sometido. Además consideramos preferencia por

Dra. Dulce; María Figueredo de Armas; Bárbara Reyes Iglesias

135

Recursos relacionados con los exámenes de detección del cáncer de cuello uterino  

Cancer.gov

El NCI tiene información completa y de base científica sobre prevención, exámenes selectivos de detección, diagnóstico, tratamiento, genética y cuidados de apoyo relacionados con el cáncer. Nuestros especialistas en información pueden responder preguntas relacionadas con el cáncer, entre ellas, las que tienen que ver con los exámenes de detección y el tratamiento del cáncer de cuello uterino. Puede comunicarse con nosotros por teléfono, correo electrónico o mensajería instantánea (el chat solo está disponible en inglés).

136

BIOPSIE RÉNALE : CORRÉLATION CLINICO-PATHOLOGIQUE Expérience libanaise  

Microsoft Academic Search

RÉSUMÉ : Notre travail est une étude rétrospective et descriptive effectuée dans un centre universitaire hospitalier et regroupant 143 malades ayant subi des biopsies rénales pour une suspicion de glomérulo - pathie, de janvier 1989 à décembre 2000. Les glomé - rulonéphrites (GN) les plus fréquemment retrouvées étaient : la glomérulonéphrite mésangiale p r o l i f é r

Tony EL MURR; Elie GHAYAD

137

[Clinico-genetic aspects of the neurocutaneous syndrome].  

PubMed

Clinical studies of skin manifestations were accomplished in children with inborn and early organic lesions of the nervous system and in different age groups of normal children. A total of 1320 ill children were examined to reveal 234 with skin syndromes. Of this number, 228 children were examined clinically. 2932 children, including 300 newborns, 507 children of preschool age and 2125 schoolchildren were examined for control purposes. The frequency of skin manifestations in different groups of ill and normal children was analyzed. PMID:7415682

Bazarov, K B; Mironov, A I; Guzeev, G G; Sharets, Iu D

1980-01-01

138

[Clinico-pathological evaluation of patients with homozygous familial hypercholesterolemia].  

PubMed

The authors have studied 8 patients with Homozygous Familial Hypercholesterolemia (FHO) an autosomal genetic dominant disease due to mutation of the gene encoding a cell surface receptor for LDL. Anatomic and pathologic abnormalities caused by LDL-cholesterol and B-Apolipoprotein high plasma levels were found. We also measured malondialdehyde levels in plasma and atherosclerotic plaques of the only autoptic case observed. MDA-levels are an index of lipid peroxidation. Cutaneous xanthomatosis lesions and severe cardiovascular disease were also present. PMID:1745828

D'Armiento, F P; Di Gregorio, F; Napoli, C; Colasanti, P; Posca, T; Calì, A

1991-09-01

139

[Hereditary ovarian carcinomas: clinico-biological features and treatment].  

PubMed

Hereditary ovarian cancers account for 10% of all cases. Two major syndromes with dominant autosomal transmission are identified. The most common one is breast-ovarian cancer syndrome due to BRCA1 and BRCA2 genes mutations, and the Lynch syndrome with mutated MMR genes is the other. Alterations in homologous recombination specifically observed in ovarian cancer with BRCA defects associated to Parp inhibition create a synthetic lethality of special interest. Numerous studies are in progress to explore this promising new approach. Furthermore, it seems that carcinogenesis of these two syndromes are different, suggesting alternative therapeutic options in the near future in order to improve prognosis of ovarian carcinomas. PMID:24555961

Floquet, Anne; Stoeckle, Eberhard; Croce, Sabrina; Longy, Michel; Mc Grogan, Gaétan; Barouk, Emmanuelle; Bubien, Virginie; Garbay, Delphine; Joly, Eglantine; Guyon, Frédéric

2014-02-01

140

The epigenomics revolution in myelodysplasia: a clinico-pathological perspective.  

PubMed

Rapid advances in molecular technologies are continually re-shaping the way we view and understand the mechanisms driving oncogenesis. The last decade has witnessed unparalleled change in the biology and therapy of the myelodysplastic syndromes (MDS), a heterogeneous collection of clonal myeloid disorders characterised by ineffective haematopoiesis and susceptibility to acute leukaemia transformation. Pivotal studies demonstrating the positive effects of hypomethylating agents on clinical outcome have brought an 'epigenomics revolution' to this disease, emphasising the importance of epigenetic mechanisms to the underlying pathogenesis of MDS. One of the most important future challenges in the MDS field will be to determine whether epigenetic therapies can be made more 'targeted' through identification of biomarkers which define subsets of patients most likely to benefit from treatment. A wave of novel mutations have recently been reported in MDS and other myeloid disorders, several of which regulate endogenous methylation networks within cells (including TET2, DNMT3A, IDH and EZH2). The relevance of these lesions in being able to predict response to epigenetic modulators and their correlation with epigenetic signatures in MDS are beginning to emerge. PMID:21881538

Tan, Peter T; Wei, Andrew H

2011-10-01

141

Clinico-radiologic Findings in Group II Caudal Regression Syndrome  

PubMed Central

Caudal regression syndrome (CRS) is a rare congenital abnormality in which a segment of the lumbo-sacral spine and spinal cord fails to develop. The severity of the morphologic derangement inversely correlates with residual spinal cord function. We present a case report of a 10-year-old girl with Group 2 CRS, to emphasize clinical and radiologic findings in this rare abnormality. PMID:24083063

Sharma, Pankaj; Kumar, Sheo; Jaiswal, Awdesh

2013-01-01

142

Progressive leptomeningeal fibrosis: a clinico-pathological case report.  

PubMed

A female patient developed persistent facial pain beginning at age 19 years. Intermittent motor and sensory disturbances referable to one hemisphere began nine years later and by the age of 41 she had developed signs of increased intracranial pressure. Exploratory craniotomy revealed replacement of the leptomeninges by thick, fibrous tissue. The histological appearance was that of a chronic, benign and minimally infiltrative process with a mild, non-specific inflammatory component, underlying cortical ischaemic changes, and white matter oedema. The lesion resembled nodular fasciitis, a soft tissue process. No cause of the reactive fibrosis of the meninges in this case is known. PMID:6842233

Chalif, D; Duchen, L W; Marshall, J; Hayward, R

1983-03-01

143

Progressive leptomeningeal fibrosis: a clinico-pathological case report.  

PubMed Central

A female patient developed persistent facial pain beginning at age 19 years. Intermittent motor and sensory disturbances referable to one hemisphere began nine years later and by the age of 41 she had developed signs of increased intracranial pressure. Exploratory craniotomy revealed replacement of the leptomeninges by thick, fibrous tissue. The histological appearance was that of a chronic, benign and minimally infiltrative process with a mild, non-specific inflammatory component, underlying cortical ischaemic changes, and white matter oedema. The lesion resembled nodular fasciitis, a soft tissue process. No cause of the reactive fibrosis of the meninges in this case is known. Images PMID:6842233

Chalif, D; Duchen, L W; Marshall, J; Hayward, R

1983-01-01

144

[Clinico-morphological signs of hormone-producing ovarian tumors].  

PubMed

Apparent signs of hormonal activity were observed in 65.3% of patients with hormone-producing ovarian tumors of different histology. Feminization was evident in 69.1% of cases of granulosa-stromal cell tumors: it was most often seen in patients with mixed theca-granulosa cell tumors (86.2%) but was least frequent in those with Brenner's tumor (22.2%). The occurrence of proliferative lesions of the uterus such as hyperplasia of the endometrium, cervical canal polyps and uterine myoma (81.8%) was higher in patients with granulosa-stromal cell tumors, too, the highest rate being observed for cases of mixed theca-granulosa cell tumors (93.1%) whereas the lowest--for patients with Brenner's tumor (27.8%). Various clinical signs of masculinization were most often seen in cases of androblastoma (79.2%) whereas the proliferative disorders in that group were rare (12.5%). As a result, the authors placed mixed theca-granulosa cell, theca cell, granulosa cell tumors and Brenner's tumor in the order of decreasing feminizing activity. In the granulosa-stromal cell tumor subgroup, masculinization was most often observed in granulosa cell tumor patients (12.1%). PMID:1662840

Adamian, R T

1991-01-01

145

[Clinico-mycological study of onychomycosis in elderly patients].  

PubMed

Physical examination of nails was carried out in 210 elderly patients and nail scrapings were obtained from onychomycosis suggested lesions in order to determine their causative agents, incidence and clinical characteristics. Diagnostic was confirmed by the isolation of the agents from 74 patients, mainly from toe-nails (incidence 35.2). Tinea pedis occurred in 25% of the cases and Diabetes mellitus was the most prevalent associated disease and the most frequent clinical characteristics were the thickening, the opacity and the presence of longitudinal strias in the surface of the nails. It was compared the results obtained by microscopic examination and by culture. Trichophyton rubrum was the most common dermatophyte isolated; Candida parapsilosis was dominant among Candida species. PMID:8278750

Rodríguez-Soto, M E; Fernández-Andreu, C M; Moya Duque, S; Rodríguez Díaz, R M; Martínez-Machín, G

1993-01-01

146

Where's the Beef? ConAgra's Approach to Energy Sources & Efficiency in Meat Processing  

E-print Network

ConAgra Foods, Inc. is a diversified international food company. ConAgra operating companies work interdependently across the food chain with 82,000 employees in 35 countries around the world. Sustainable development is a vital ConAgra business...

Kananen, T. M.

147

Apoyo a Estudios Geodinamicos con GPS en Guatemala  

NASA Astrophysics Data System (ADS)

El Instituto Geografico Nacional de Guatemala implemento 17 estaciones GNSS en el año 2009, como un proyecto de credito mixto de donacion de equipamiento del Gobierno de Suiza, el cual, este equipamiento de estaciones CORS GNSS es un sistema de recepción y transmisión de datos crudos GPS RInex que utiliza la tecnologia Spider Web de Leica, asi mismo este sistema esta sirviendo para el espablecimiento de un marco geodesico nacional de coordenadas geodesicas oficiales, el cual se calculan u obtienen las velocidades en tiempos temporales programados de las 17 Estaciones CORS. La infraestructura del marco geodesico de Guatemala esta sirviendo de base para las aplicaciones de estudios geodinamicos como el monitoreo de del desplazamiento de las placas tectonicas por medio de un estudio que se inicio en el año de 1999, llamado medicion con GPS el sistema de Fallas de los rios Polochic Motagua de Guatemala, tambien para un estudio que se implemento para deformación de corteza terrestre local en un Volcan Activo de Guatemala llamado Pacaya. Para el estudio de medicion con GPS en el sistema de falla de los Rios del polochic Motagua se implementaron 16 puntos para medir con GPS de dos frecuencias en el año de 1999, el cual, tres puntos son estaciones geodesicas CORS IGS llamados GUAT, ELEN y HUEH, despues en el año de 2003 se hizo otra medicion en un total de 20 puntos, que permitió calcular las velocidades de desplazamieinto de los puntos en mención, usando como referencia el modelo NUVEL 1A de DeMets de la placa de Norteamerica. Este estudio fue en cooperación internacional por la universidad de Nice de Francia y el IGNde Francia. Para el estudio del monitoreo con GPS del volcan activo de Guatemala, se implementaron cuatro puntos al rededor del volcan, el cual, se realizan cuatro mediciones al año, que permiten determinar axialmente la distancias entre los puntos, y rebisar estadisticamente cual es el comportamiento de las distancias en funcion del tiempo, si existen diferencias graduales crecientes o decrecientes, que nos da un indicativo del desplazamiento de la corteza terrestre al rededor del volcan.

Robles, V. R.

2013-05-01

148

El teatro como reflexión colectiva: Conversación con Sergio Corrieri  

E-print Network

grandes rasgos, por supuesto. Por nuestra convivencia en la zona y por los multiples canales naturales que eso nos brinda, nosotros estamos actualizados de la problemática. Aparte, con el tiempo, el Escambray ha ido perdiendo artistas particulares en el... gente del Escambray se nos queja. Uno de los aspectos más interesantes, a mi modo de ver, de la experiencia del Teatro Escambray es que todo este proceso se ha ido haciendo sobre la marcha, ha ido surgiendo, como tú decías hace poco, de la práctica...

Luzuriaga, Gerardo

1983-04-01

149

Do Well, Be Well with Diabetes 2013 1 Formulario de Conclusin para Personas con Diabetes Formulario de Conclusin para Personas con Diabetes 201  

E-print Network

Do Well, Be Well with Diabetes ­ 2013 1 Formulario de Conclusión para Personas con Diabetes Formulario de Conclusión para Personas con Diabetes ­ 201 Si usted NO TIENE diabetes, por favor NO LLENE este últimos cuatro números de mi número telefónico son __ __ __ __. C. Marque todas las clases sobre diabetes

150

Do Well, Be Well with Diabetes 2013 1 Formulario de Registro para Personas con Diabetes Formulario de Registro para Personas con Diabetes 2013  

E-print Network

Do Well, Be Well with Diabetes ­ 2013 1 Formulario de Registro para Personas con Diabetes Formulario de Registro para Personas con Diabetes ­ 2013 Si usted NO TIENE diabetes, por favor NO LLENE este sobre diabetes en el Condado de _______________. D. El código postal en mi casa es __ __ __ __ __. E

151

Cannabinoids and cancer: pros and cons of an antitumour strategy  

PubMed Central

In the last two decades, research has dramatically increased the knowledge of cannabinoids biology and pharmacology. In mammals, compounds with properties similar to active components of Cannabis sativa, the so called ‘endocannabinoids', have been shown to modulate key cell-signalling pathways involved in cancer cell growth, invasion and metastasis. To date, cannabinoids have been licensed for clinical use as palliative treatment of chemotherapy, but increased evidences showed direct antiproliferative actions of cannabinoid agonists on several tumour cells in vitro and in animal models. In this article, we will review the principal molecular pathways modulated by cannabinoids on cancer and summarize pros and cons evidence on the possible future use of endocannabinoid-based drugs in cancer therapy. PMID:16501583

Bifulco, Maurizio; Laezza, Chiara; Pisanti, Simona; Gazzerro, Patrizia

2006-01-01

152

RoboCon: Operator interface for robotic applications  

SciTech Connect

Carnegie Mellon U. and ORNL`s Robotics and Process Systems Division are developing a state-of-the-art robot operator control station (RoboCon) with standardized hardware and software control interfaces to be adaptable to a variety of remote and robotic equipment currently funded by DOE`s Office of Science & Technology Robotics Technology Development Program. The human operation and telerobotic and supervisory control of sophisticated and remote and robotic systems is a complex, tiring, and non-intuitive activity. Since decontamination & decommissioning, selective equipment removal, mixed waste operations, and in-tank cleanup are going to be a major future activity in DOE environmental restoration and waste management cleanup agenda, it seems necessary to utilize an operator control station and interface which maximizes operator comfort and productivity.

Schempf, H.; Warwick, J.; Fung, M.; Chemel, B.; Blackwell, M.

1996-12-31

153

NYC club to cogenerate with Con Ed's OK  

SciTech Connect

Consolidated Edison has given its first approval for a 120-kW cogeneration system at the Downtown Athletic Club because the club sized the project for peak shaving and plans to continue relying on the utility for supplemental rather than standby service at its former rate schedule. The two 60-kW Tecogen cogeneration units are part of a larger $268,000 energy conservation project that includes energy management systems, a powerline carrier system, and renovation of the building's condensate return system. Payback estimates for the investment are 18 months. The gas-fired cogeneration system will lower unit costs for fuel. Con Ed's opposition to other cogeneration projects focused on the problems of providing only standby power.

Berkovitch, E.

1985-07-22

154

Neogene sequence stratigraphy, Nam Con Son Basin, offshore Vietnam  

SciTech Connect

An integrated well log, biostratigraphic, and seismic stratigraphic study of Miocene to Recent deltaic sediments deposited in the Nam Con Son Basin offshore from southern Vietnam shows the influence of eustacy and tectonics on sequence development. Sediments consist of Oligocene non-marine rift-basin fill (Cau Formation), early to middle Miocene tide-dominated delta plain to delta front sediments (TB 1.5 to TB 2.5, Due and Thong Formations), and late Miocene to Recent marine shelf sediments (TB. 2.6 to TB 3.1 0, Mang Cau, Nam Con Son, and Bien Dong Formations). Eustacy controlled the timing of key surfaces and sand distribution in the tectonically-quiet early Miocene. Tectonic effects on middle to late Miocene sequence development consist of thick transgressive systems tracts due to basin-wide subsidence and transgression, sand distribution in the basin center, and carbonate sedimentation on isolated fault blocks within the basin. Third-order sequence boundaries (SB) are identified by spore peaks, sand stacking patterns, and channel incision. In the basin center, widespread shale beds with coal occur above sequence boundaries followed by transgressive sandstone units. These TST sandstones merge toward the basin margin where they lie on older HST sandstones. Maximum flooding surfaces (MFS) have abundant marine microfossils and mangrove pollen, a change in sand stacking pattern, and often a strong seismic reflection with downlap. Fourth-order genetic-type sequences are also interpreted. The MFS is the easiest marker to identify and correlate on well logs. Fourth-order SB occur within these genetic units but are harder to identify and correlate.

McMillen, K.J. (Beaver Creek Tech. Co., Mason, TX (United States)); Do Van Luu; Lee, E.K.; Hong, S.S. (PEDCO, Ho Chi Minh City (Viet Nam))

1996-01-01

155

Neogene sequence stratigraphy, Nam Con Son Basin, offshore Vietnam  

SciTech Connect

An integrated well log, biostratigraphic, and seismic stratigraphic study of Miocene to Recent deltaic sediments deposited in the Nam Con Son Basin offshore from southern Vietnam shows the influence of eustacy and tectonics on sequence development. Sediments consist of Oligocene non-marine rift-basin fill (Cau Formation), early to middle Miocene tide-dominated delta plain to delta front sediments (TB 1.5 to TB 2.5, Due and Thong Formations), and late Miocene to Recent marine shelf sediments (TB. 2.6 to TB 3.1 0, Mang Cau, Nam Con Son, and Bien Dong Formations). Eustacy controlled the timing of key surfaces and sand distribution in the tectonically-quiet early Miocene. Tectonic effects on middle to late Miocene sequence development consist of thick transgressive systems tracts due to basin-wide subsidence and transgression, sand distribution in the basin center, and carbonate sedimentation on isolated fault blocks within the basin. Third-order sequence boundaries (SB) are identified by spore peaks, sand stacking patterns, and channel incision. In the basin center, widespread shale beds with coal occur above sequence boundaries followed by transgressive sandstone units. These TST sandstones merge toward the basin margin where they lie on older HST sandstones. Maximum flooding surfaces (MFS) have abundant marine microfossils and mangrove pollen, a change in sand stacking pattern, and often a strong seismic reflection with downlap. Fourth-order genetic-type sequences are also interpreted. The MFS is the easiest marker to identify and correlate on well logs. Fourth-order SB occur within these genetic units but are harder to identify and correlate.

McMillen, K.J. [Beaver Creek Tech. Co., Mason, TX (United States); Do Van Luu; Lee, E.K.; Hong, S.S. [PEDCO, Ho Chi Minh City (Viet Nam)

1996-12-31

156

Gleevec disminuye la recidiva del cáncer en pacientes con tumor estromal gastrointestinal primario  

Cancer.gov

Los resultados preliminares de un estudio clínico grande aleatorio y controlado con placebo, en pacientes con tumor estromal gastrointestinal (GIST) primario, un tipo de tumor que por lo general se encuentra en el estómago o en el intestino delgado, demostraron que los pacientes a los que se administró mesilato de imatinib (Gleevec®) luego de la extirpación total de su tumor tuvieron una probabilidad significativamente menor de padecer una recidiva del cáncer en comparación con aquellos a los que no se administró imatinib.

157

Non Invasive Biomedical Analysis. Breath Networking Session at PittCon 2011, Atlanta, Georgia Non Invasive Biomedical Analysis. Breath Networking Session at PittCon 2011, Atlanta, Georgia  

Microsoft Academic Search

Background This was the second year that our breath colleagues organized a networking session at the Pittsburgh Conference and Exposition, or 'PittCon' (www.pittcon.org\\/). This time it was called 'Non Invasive Biomedical Analysis' to broaden the scope a bit, but the primary focus remained on exhaled breath diagnostics. As reported last year in the Journal of Breath Research, PittCon continues to

Joachim D. Pleil

2011-01-01

158

Pros, Cons, and Alternatives to Weight Based Cost Estimating  

NASA Technical Reports Server (NTRS)

Many cost estimating tools use weight as a major parameter in projecting the cost. This is often combined with modifying factors such as complexity, technical maturity of design, environment of operation, etc. to increase the fidelity of the estimate. For a set of conceptual designs, all meeting the same requirements, increased weight can be a major driver in increased cost. However, once a design is fixed, increased weight generally decreases cost, while decreased weight generally increases cost - and the relationship is not linear. Alternative approaches to estimating cost without using weight (except perhaps for materials costs) have been attempted to try to produce a tool usable throughout the design process - from concept studies through development. This paper will address the pros and cons of using weight based models for cost estimating, using liquid rocket engines as the example. It will then examine approaches that minimize the impct of weight based cost estimating. The Rocket Engine- Cost Model (RECM) is an attribute based model developed internally by Pratt & Whitney Rocketdyne for NASA. RECM will be presented primarily to show a successful method to use design and programmatic parameters instead of weight to estimate both design and development costs and production costs. An operations model developed by KSC, the Launch and Landing Effects Ground Operations model (LLEGO), will also be discussed.

Joyner, Claude R.; Lauriem, Jonathan R.; Levack, Daniel H.; Zapata, Edgar

2011-01-01

159

Influencia familiar sobre la conducta alimentaria y su relación con la obesidad infantil  

Microsoft Academic Search

RESUMEN. La conducta alimentaria es el conjunto de acciones que establecen la relación del ser humano con los alimentos. Se acepta generalmente que los comportamientos frente a la alimentación se adquieren a través de la experiencia directa con la comida, por la imitación de modelos, la disponibilidad de alimentos, el estatus social, los simbolismos afectivos y las tradiciones culturales. Además

Santos JL

160

Derivaciones perezosas en Programaci'on L'ogica con restricciones ecuacionales*  

E-print Network

Derivaciones perezosas en Programaci'on L'ogica con restricciones(H=E) a'una el estilo de programaci'on l'ogica basado en cl'ausulas de Horn, el paradigma* * basado en ecuaciones (condi- cionales) y la programaci'on con restricciones. Como n'ucleo de su sem

Alpuente, María

161

Diventa Social Media Trainer Aumenta le tue possibilit occupazionali con competenze Web 2.0 e  

E-print Network

Diventa Social Media Trainer · Aumenta le tue possibilità occupazionali con competenze Web 2.0 e marketing. Perché partecipare: · Riceverai una Formazione per diventare un Social Media Trainer formative, aiutando un membro dello staff aziendale a familiarizzare con gli strumenti Social Media. Questo

Robbiano, Lorenzo

162

ConPor: um modelo de gerao conceitual para o Lucia Specia, Lucia Helena Machado Rino  

E-print Network

ConPor: um modelo de geração conceitual para o português Lucia Specia, Lucia Helena Machado Rino ­ 13565-905 ­ São Carlos ­ SP ­ Brasil {lspecia,lucia}@dc.ufscar.br Abstract. This paper describes Con

Specia, Lucia

163

Dos casos de intoxicación por contaminación de maíz con Datura stramonium en ganado vacuno  

Microsoft Academic Search

Resumen: Recientemente hemos observado dos intoxicaciones en ganado vacuno lechero, en granjas de Cataluña, debidas a la ingestión de estramonio (Datura stramonium). La planta había sido en ambos casos erróneamente recolectada junto con el maíz empleado para la alimentación de los animales. El cuadro fue leve y, básicamente, cursó con problemas digestivos y descenso en la producción lechera, y remitió

Bofill FX; Bofill J

2007-01-01

164

ccsd00001226 Ultracold atoms con ned in rf-induced two-dimensional trapping potentials  

E-print Network

ccsd­00001226 (version 1) : 29 Feb 2004 Ultracold atoms con#12;ned in rf-induced two atoms proposed by O. Zobay and B. M. Garraway [1]. It relies on adiabatic potentials for atoms dressed by a rf #12;eld in an inhomogeneous magnetic #12;eld. This trap is well suited to con#12;ne atoms tightly

165

La salud en personas con discapacidad intelectual en España: estudio europeo POMONA-II  

PubMed Central

Introducción Estudios internacionales demuestran que existe un patrón diferenciado de salud y una disparidad en la atención sanitaria entre personas con discapacidad intelectual (DI) y población general. Objetivo Obtener datos sobre el estado de salud de las personas con DI y compararlos con datos de población general. Pacientes y métodos Se utilizó el conjunto de indicadores de salud P15 en una muestra de 111 sujetos con DI. Los datos de salud encontrados se compararon según el tipo de residencia de los sujetos y se utilizó la Encuesta Nacional de Salud 2006 para comparar estos datos con los de la población general. Resultados La muestra con DI presentó 25 veces más casos de epilepsia y el doble de obesidad. Un 20% presentó dolor bucal, y existió una alta presencia de problemas sensoriales, de movilidad y psicosis. Sin embargo, encontramos una baja presencia de patologías como la diabetes, la hipertensión, la osteoartritis y la osteoporosis. También presentaron una menor participación en programas de prevención y promoción de la salud, un mayor número de ingresos hospitalarios y un uso menor de los servicios de urgencia. Conclusiones El patrón de salud de las personas con DI difiere del de la población general, y éstas realizan un uso distinto de los servicios sanitarios. Es importante el desarrollo de programas de promoción de salud y de formación profesional específicamente diseñados para la atención de personas con DI, así como la implementación de encuestas de salud que incluyan datos sobre esta población. PMID:21948011

Martínez-Leal, Rafael; Salvador-Carulla, Luis; Gutiérrez-Colosía, Mencía Ruiz; Nadal, Margarida; Novell-Alsina, Ramón; Martorell, Almudena; González-Gordón, Rodrigo G.; Mérida-Gutiérrez, M. Reyes; Ángel, Silvia; Milagrosa-Tejonero, Luisa; Rodríguez, Alicia; García-Gutiérrez, Juan C.; Pérez-Vicente, Amado; García-Ibáñez, José; Aguilera-Inés, Francisco

2011-01-01

166

Soluciones analiticas AL problema de jets con velocidad de eyeccion variable EN EL tiempo  

Microsoft Academic Search

Se presenta un nuevo metodo que permite resolver de manera exacta y analitica las ecuaciones que describen un jet hipersonico con velocidad de eyeccion variable en el tiempo. El metodo se basa en consideraciones sencillas de conservacion de momento para las superficies de trabajo que se forman en el interior del jet. Como ejemplo, se presentan soluciones para jets con

J. Canto; A. C. Raga; P. D'Alessio

1998-01-01

167

Estimación de observaciones faltantes en series de tiempo usando métodos multivariados con restricciones  

Microsoft Academic Search

Para tener éxito en el modelamiento de cualquier fenómeno físico, es importante disponer de una fuente de información completa. En este documento se plantea la reconstrucción o estimaci´on de observaciones faltantes en series de tiempo múltiples, siguiendo la metodología de Guerrero (1989) de pron´osticos con restricciones, las cuales vienen dadas por información adicional relacionada con el modelo que tiene en

María Ana Velásquez Gallo; Jorge Martínez Collantes

2010-01-01

168

Accesibilidad para personas con debilidad auditiva Mac OS X Snow Leopard  

E-print Network

Accesibilidad para personas con debilidad auditiva Mac OS X Snow Leopard ASIC ­ 18 de noviembre de LEOPARD MAC OS X Snow Leopard ofrece algunas ayudas para personas sordas o con problemas para escuchar Snow Leopard ASIC ­ 18 de noviembre de 2010 Pág. 2 de 14 1. Recomendaciones previas frente al uso del

Fernández de Córdoba, Pedro

169

Accesibilidad para personas con debilidad motriz Mac Os X Snow Leopard  

E-print Network

Accesibilidad para personas con debilidad motriz Mac Os X Snow Leopard ASIC ­ 18 de noviembre de LEOPARD Si usted tiene problemas para utilizar el teclado, el ratón o el trackpad de su portátil, puede para personas con debilidad motriz Mac Os X Snow Leopard ASIC ­ 18 de noviembre de 2010 Pág. 2 de 9

Fernández de Córdoba, Pedro

170

PROBLEMAS DE CONDUCTA EN EL NIÑO CON TDAH: ESTRATEGIAS DE INTERVENCIÓN EN EL AULA  

Microsoft Academic Search

Los estudios epidemiológicos revelan que el Trastorno por Déficit de Atención con o sin hiperactividad se presenta en un 3 hasta un 6% de los niños en edad escolar por lo tanto, en un aula de educación primaria o secundaria podemos encontrar la razonable cifra de 1 o 2 niños con este trastorno. La sintomatología del TDAH implica dos bloques

Isabel Orjales Villar

171

LA COLABORACIÓN ENTRE PEDIATRAS Y PSICÓLOGOS EN EL DIAGNÓSTICO Y TRATAMIENTO DE NIÑOS CON TDAH  

Microsoft Academic Search

En los Estados Unidos, está aumentando la carencia de psiquiatras, y pacientes con necesidad de medicación psicotrópica a menudo se enfrentan a largas esperas y servicios limitados. Para disminuir la brecha creciente entre la oferta y la demanda, están incorporán- dose personas con capacidad para prescribir, formadas fuera de los escenarios médicos tradicionales. A pesar de que tradicional- mente los

George M. Kapalka

172

Meeting Report: Breath Biomarkers Networking Sessions at PittCon 2010, Orlando, Florida  

EPA Science Inventory

The Pittsburgh Conference and Exposition, or "PittCon" (www.pittcon.org/), is one of the largest international conferences for analytical chemistry and instrumentation typically attracting about 25,000 attendees and 1,000 commercial exhibitors. PittCon began in 1950 as a small sp...

173

in collaborazione con: Sovraintendenza ai Beni Culturali del Comune di Roma  

E-print Network

in collaborazione con: Sovraintendenza ai Beni Culturali del Comune di Roma con il patrocinio di l'Università `La Sapienza' di Roma ed ha come obiettivo la formazione del lighting designer e del-Tokyo, Artemide-Dubai, Regent-Basilea, Studio Fabertechnica S.a.S-Roma, Studio Annunziata&Terzi-Roma, Studio GMS

Di Pillo, Gianni

174

Bienvenidos a Columbia Dental: En Columbia Dental estamos comprometidos en proveerle con cuidado dental de altura.  

E-print Network

departamentos especializados, incluyendo Implantes Dentales. Su primera cita en Columbia Dental será con unBienvenidos a Columbia Dental: En Columbia Dental estamos comprometidos en proveerle con cuidado dental de altura. Columbia Dental le ofrece una amplia variedad de servicios dentales en todos nuestros

Grishok, Alla

175

Los regímenes monetarios con paridades irrevocablemente fijas: algunas reflexiones de la experiencia argentina  

Microsoft Academic Search

Resumen. Recientemente, ha habido en distintas economías periféricas intentos por im- plantar sistemas cambiarios con paridades irrevocablemente fijas. Este artículo expone brevemente las ventajas y desventajas que, teóricamente, cabe esperar de los mismos. Con esta base teórica, se analiza el régimen cambiario argentino de los años noventa (conocido como currency-board). Se concluye que el fracaso final del mismo se debe

Daniel Coq Huelva

2007-01-01

176

iCons students work on science problems that capture their interest and prepare them for  

E-print Network

generation of technology leaders by focusing on problem-based learning. Through courses in the 18-credit, four-year concentration, students use scientific methods in a team environment where communication class of iCons scholars launched their iCons careers by studying cholera in Haiti, the impact

Auerbach, Scott M.

177

BriTTen fesTival ClassiC ConCerT series  

E-print Network

SeaSon 07 th The UniversiTy of ChiCago presenTs 2o13/14 ConCerT series #12;BriTTen fesTival ClassiC ConCerT series early mUsiC series paCifiCa qUarTeT ConTempo jazz aTThe logan mUsiC aCross genres during the season, create a Flexible series from the delightful array of Chicago Presents concerts

Butler, Laurie J.

178

LA TERAPIA FACILITADA POR ANIMALES DE COMPAÑÍA COMO PROGRAMA DE REHABILITACIÓN ADJUNTO PARA PERSONAS CON DIAGNÓSTICO DE ESQUIZOFRENIA CRÓNICA  

Microsoft Academic Search

Coincidiendo con el surgimiento de la psiquiatría comunitaria, ha habido un progresivo proceso de desinstitucionalización de los pacientes psiquiátricos; seleccionando a los menos discapacitados para los recursos comunitarios y dejando los pacientes con más discapacidad al cuidado de las instituciones. La rehabilitación pretende afrontar la discapacidad para realizar actividades, con la finalidad de mejorar la desventaja social consecuencia del deterioro

Victoria Villalta Gil; Susana Ochoa Güerre

2007-01-01

179

SimpCon a Simple and Efficient SoC Interconnect Martin Schoeberl  

E-print Network

definition from ARM. The specification defines three different busses: Advanced High-performance Bus (AHB, cache, and external memory to the processor. Peripheral devices are con- nected to the APB. A bridge

180

Propuesta de Proyecto Fin de Carrera o Grado Implementacin de una aplicacin web con  

E-print Network

Propuesta de Proyecto Fin de Carrera o Grado Implementación de una aplicación web con soporte WPS Service (WPS) del Open Geospatial Consortium (OGC), en el que se publicarán distintos algoritmos que

Fraguela, Basilio B.

181

UNIDAD GUADALAJARA La Unidad Guadalajara del Cinvestav se inici el 14 de noviembre de 1988 con  

E-print Network

Comercio y Fomento Indus- trial. Este proyecto fue parte del Programa de Transferencia de Tecnología al desarrollo tecnológico con las compañías más im- portantes de la industria electrónica internacional

182

UNIDAD GUADALAJARA La Unidad Guadalajara del Cinvestav se inici el 14 de noviembre de 1988 con  

E-print Network

Comercio y Fomento Indus- trial. Este proyecto fue parte del Programa de Transferencia de Tecnología al desarrollo tecnológico con las compañías más im- portantes de la industria electrónica internacional. Los

183

Sub-Workflow Interoperability, the Pros and Cons Beth Plale1  

E-print Network

Sub-Workflow Interoperability, the Pros and Cons Beth Plale1 , Yuan Luo1 is run on one system and another portion on another system. As with social media sites, working within a single framework can be limiting. Interoperability

Plale, Beth

184

algunos estimadores "naturales", junto con diversas propiedades de interes (sesgo, varianza, ECM);  

E-print Network

-2015 October 30, 2014 1 / 22 #12;Derivadas de funciones de densidad/masa Variable X con funci´on de densidad funci´on de densidad conjunta f (x; ) dada por f (x; ) = n j=1 f (xj ; ), con x = (x1, . . . , xn) sopn densidad es f (x; ) = 1 e-x/ , para x > 0 . Obs´ervese que E(X) = (1/) = y que V(X) = (1/2) = 2. Como ln

Fernández Gallardo, Pablo

185

ConPAHS - a software package for control of piecewise-affine hybrid systems  

Microsoft Academic Search

The software package ConPAHS facilitates control design of continuous-time piecewise-affine hybrid systems on polytopes. For the control objective of reaching a particular state from a specified initial state, the output of the package is a piecewise-affine control law. After a short review of the control theory for this problem, the paper presents the functional specification of ConPAHS, the objected oriented

Pieter Collins; Anton Kuut; Margreet Nool; Mihaly Petreczky; Jan H. van Schuppen

2006-01-01

186

Estudio de los NIH señala una relación de la tomografía computarizada (TC) en la infancia con leucemia y con cáncer de cerebro más tarde  

Cancer.gov

Niños y adultos jóvenes a quienes se les hicieron exploraciones muchas veces con tomografía computarizada (TC), una herramienta de diagnóstico de uso frecuente, tienen un riesgo ligeramente mayor de padecer leucemia y tumores cerebrales en la década posterior a su primera tomografía.

187

Evaluation of the ACT*DE*CON{sup SM} process for treating gunite tank sludge  

SciTech Connect

A test was conducted to evaluate this process for selectively removing actinides from Gunite tank sludge. Mixed waste sludge from Gunite tank W-6 was subjected to the ACT*DE*CON selective leaching process. (Nearly all the TRU content was attributed to Pu.) The sludge sample was first washed with 0.01M NaOH to remove excess sodium and nitrate in the interstitial liquid supernatant. The washed wet solids were treated with the ACT*DE*CON solvent (aqueous carbonate solution containing a chelating agent and an oxidant), using a ratio of 20 ml solvent per gram wet solids. Sludge and solvent were separated by centrifugation, and the ACT*DE*CON treatment was repeated twice. Analyses showed that 71% of the solids in the sludge were dissolved while 80% of the TRU-waste components dissolved. Low separation of the TRU-waste components from other components of the sludge mixture is indicated. Almost all the U and Ca were removed from the sludge. For sludges where most of the TRU content is Pu, the ACT*DE*CON process as tested is not effective in rendering the sludge a non-TRU waste. It is recommended that ACT*DE*CON be optimized for this specific application and that other processes using different chelating and oxidizing agents be tested. Also, the ACT*DE*CON process should be tested on TRU mixed waste in which most of the TRU elements are not Pu.

Spencer, B.B.; Chase, C.W.; Egan, B.Z.

1996-05-01

188

SLUDGE PARTICLE SEPAPATION EFFICIENCIES DURING SETTLER TANK RETRIEVAL INTO SCS-CON-230  

SciTech Connect

The purpose of this document is to release, into the Hanford Document Control System, FA1/0991, Sludge Particle Separation Efficiencies for the Rectangular SCS-CON-230 Container, by M. Epstein and M. G. Plys, Fauske & Associates, LLC, June 2009. The Sludge Treatment Project (STP) will retrieve sludge from the 105-K West Integrated Water Treatment System (IWTS) Settler Tanks and transfer it to container SCS-CON-230 using the Settler Tank Retrieval System (STRS). The sludge will enter the container through two distributors. The container will have a filtration system that is designed to minimize the overflow of sludge fines from the container to the basin. FAI/09-91 was performed to quantify the effect of the STRS on sludge distribution inside of and overflow out of SCS-CON-230. Selected results of the analysis and a system description are discussed. The principal result of the analysis is that the STRS filtration system reduces the overflow of sludge from SCS-CON-230 to the basin by roughly a factor of 10. Some turbidity can be expected in the center bay where the container is located. The exact amount of overflow and subsequent turbidity is dependent on the density of the sludge (which will vary with location in the Settler Tanks) and the thermal gradient between the SCS-CON-230 and the basin. Attachment A presents the full analytical results. These results are applicable specifically to SCS-CON-230 and the STRS filtration system's expected operating duty cycles.

DEARING JI; EPSTEIN M; PLYS MG

2009-07-16

189

Concomitant administration of GonaCon™ and rabies vaccine in female dogs (Canis familiaris) in Mexico.  

PubMed

Mexico serves as a global model for advances in rabies prevention and control in dogs. The Mexican Ministry of Health (MMH) annual application of approximately 16 million doses of parenteral rabies vaccine has resulted in significant reductions in canine rabies during the past 20 years. One collateral parameter of rabies programs is dog population management. Enhanced public awareness is critical to reinforce responsible pet ownership. Surgical spaying and neutering remain important to prevent reproduction, but are impractical for achieving dog population management goals. GonaCon™, an anti-gonadotropin releasing hormone (GnRH) vaccine, was initially tested in captive female dogs on the Navajo Nation, 2008. The MMH led this international collaborative study on an improved formulation of GonaCon™ in captive dogs with local representatives in Hidalgo, Mexico in 2011. This study contained 20 bitches assigned to Group A (6 control), Group B (7 GonaCon™), and Group C (7 GonaCon™ and rabies vaccine). Vaccines were delivered IM. Animals were placed under observation and evaluated during the 61-day trial. Clinically, all dogs behaved normally. No limping or prostration was observed, in spite of minor muscle atrophy post-mortem in the left hind leg of dogs that received GonaCon™. Two dogs that began the study pregnant give birth to healthy pups. Dogs that received a GonaCon™ injection had macro and microscopic lesions consistent with prior findings, but the adverse injection effects were less frequent and lower in intensity. Both vaccines were immunogenic based on significant increases in rabies virus neutralizing antibodies and anti-GnRH antibodies in treatment Groups B and C. Simultaneous administration of GonaCon™ and rabies vaccine in Group C did not affect immunogenicity. Progesterone was suppressed significantly in comparison to controls. Future studies that monitor fertility through multiple breeding cycles represent a research need to determine the value of integrating this vaccine into dog rabies management. PMID:23871822

Vargas-Pino, Fernando; Gutiérrez-Cedillo, Verónica; Canales-Vargas, Erick J; Gress-Ortega, Luis R; Miller, Lowell A; Rupprecht, Charles E; Bender, Scott C; García-Reyna, Patricia; Ocampo-López, Juan; Slate, Dennis

2013-09-13

190

Virulence, Speciation and Antibiotic Susceptibility of Ocular Coagualase Negative Staphylococci (CoNS)  

PubMed Central

Background: Coagulase negative Staphylococci (CoNS) are common inhabitants of human skin and mucous membranes. With the emergence of these organisms as prominent pathogens in patients with ocular infections, investigation has intensified in an effort to identify important virulence factors and to inform new approaches to treatment and prevention. Aim: To isolate CoNS from ocular specimens; to study the possible virulence factors; speciation of coagulase negative staphylococci (CoNS) which were isolated from ocular complications; antibiotic susceptibility testing of ocular CoNS. Materials and Methods: The specimens were collected from the target patients who attended the Microbiology Laboratory of a tertiary care eye hospital in Coimbatore, Tamilnadu state, India. The isolates were subjected to tube and slide coagulase tests for the identification of CoNS. All the isolates were subjected to screening for lipase and protease activities. Screening for other virulence factors viz., slime production on Congo red agar medium and haemagglutination assay with use of 96-well microtitre plates. These isolates were identified upto species level by performing biochemical tests such as phosphatase test, arginine test, maltose and trehalose fermentation tests and novobiocin sensitivity test. The isolates were subjected to antibiotic susceptibility studies, based on the revised standards of Clinical and Laboratory Standards Institutes (CLSI). Results: During the one year of study, among the total 260 individuals who were screened, 100 isolates of CoNS were obtained. Lipolytic activity was seen in all the isolates, whereas 38 isolates showed a positive result for protease. A total of 63 isolates showed slime production. Of 100 isolates, 30 isolates were analyzed for haemagglutination, where 4 isolates showed the capacity to agglutinate the erythrocytes. The results of the biochemical analysis revealed that of the 100 isolates of CoNS, 43% were Staphylococcus epidermidis. The other isolates were identified as S. xylosus (n=8), S. captis (n=16), S. haemolyticus (n=10), S. saccharolyticus (n=2), S. hominis (n=5), S. saprophyticus (n=6) and S. intermedius (n=1). On the other hand, 9 isolates were not identified. In the antibiotic susceptibility analysis, it was found that most of the isolates were sensitive to vancomycin, amikacin and linczolid and resistant to cefatoxime, oxacillin, bacitracin and nalidixic acid. Conclusion: S. epidermidis was found to be predominant in causing the ocular complications. Slime production, heamagglutination, protease and lipase activities could be the putative virulence factors of CoNS. Antibiotic susceptibility patterns of CoNS against antibacterial agents revealed maximum resistance to beta lactam groups, and the resistance was found to be higher to oxacillin, and lowest to vancomycin. PMID:24995181

Priya, Ravindran; Mythili, Arumugam; Singh, Yendremban Randhir Babu; Sreekumar, Haridas; Manikandan, Palanisamy; Panneerselvam, Kanesan

2014-01-01

191

ConA-based glucose sensing using the long-lifetime azadioxatriangulenium fluorophore  

NASA Astrophysics Data System (ADS)

Fluorescent glucose sensing technologies have been identified as possible alternatives to current continuous glucose monitoring approaches. We have recently introduced a new, smart fluorescent ligand to overcome the traditional problems of ConA-based glucose sensors. For this assay to be translated into a continuous glucose monitoring device where both components are free in solution, the molecular weight of the smart fluorescent ligand must be increased. We have identified ovalbumin as a naturally-occurring glycoprotein that could serve as the core-component of a 2nd generation smart fluorescent ligand. It has a single asparagine residue that is capable of displaying an N-linked glycan and a similar isoelectric point to ConA. Thus, binding between ConA and ovalbumin can potentially be monovalent and sugar specific. This work is the preliminary implementation of fluorescently-labeled ovalbumin in the ConA-based assay. We conjugate the red-emitting, long-lifetime azadioxatriangulenium (ADOTA+) dye to ovalbumin, as ADOTA have many advantageous properties to track the equilibrium binding of the assay. The ADOTA-labeled ovalbumin is paired with Alexa Fluor 647-labeled ConA to create a Förster Resonance Energy Transfer (FRET) assay that is glucose dependent. The assay responds across the physiologically relevant glucose range (0-500 mg/dL) with increasing intensity from the ADOTA-ovalbumin, showing that the strategy may allow for the translation of the smart fluorescent ligand concept into a continuous glucose monitoring device.

Cummins, Brian; Simpson, Jonathan; Gryczynski, Zygmunt; Sørensen, Thomas Just; Laursen, Bo W.; Graham, Duncan; Birch, David; Coté, Gerard

2014-02-01

192

Pliocene to recent stratigraphy of the Cuu Long and Nam Con Son Basins, offshore Vietnam  

E-print Network

. Cuu Long and Nam Con Son Basin boundaries are indicated by dashed lines. Division of the Nam Con Son Basin into East and West sub- basins is not shown. 37 Well Log Analysis Well 04-A-1X (Figure 10) provided gamma...-ray measurements and lithostratigraphic picks based on microfossils. Sequence boundaries for LP 1 through UP-R 4 and maximum flooding surfaces (mfs) for LP 1 through 4 were identified in the gamma-ray well log. Sequence boundary and maximum flooding surface...

Yarbrough, Christopher Neil

2006-08-16

193

Un estudio financiado por los Institutos Nacionales de la Salud (NIH) muestra reducción en la mortalidad entre hombres con cáncer de próstata en grado intermedio:  

Cancer.gov

Terapia hormonal por corto tiempo administrada en combinación con radioterapia a hombres con cáncer de próstata en estadio inicial aumentó sus posibilidades de vivir más en comparación con tratamiento de radioterapia sola, según un estudio clínico patrocinado por el NCI. Los beneficios del tratamiento combinado se limitaron principalmente a pacientes con enfermedad de riesgo intermedio y no se observaron en hombres con cáncer de próstata de riesgo bajo, indican los investigadores.

194

Annotating Web Images using NOVA: NOn-conVex group College of Computer Science,  

E-print Network

Annotating Web Images using NOVA: NOn-conVex group spArsity Fei Wu College of Computer Science, NOVA is the first to introduce non-convex penalty for group selection in high-dimensional heterogeneous it uses non-convex penalty, it achieves the consistency. We demonstrate the superior performance of NOVA

Rui, Yong

195

A Static Analysis for Instance-based Con nement in Java [Extended version, 30 Nov 01  

E-print Network

of Technology Hoboken, NJ 07030 USA naumann@cs.stevens-tech.edu Abstract. A semantic de#12;nition is given for instance-based pointer con- #12;nement (alias control); this provides a form of encapsulation suited#12;ts of object-oriented programming is information hiding and encapsulation: classes and visibility

Banerjee, Anindya

196

Desactivar la conducta de miedo con seguridad percibida Karyn B. Purvis  

E-print Network

Desactivar la conducta de miedo con seguridad percibida Karyn B. Purvis David R. Cross Wendy L conductas perturbadoras (rabietas, esconderse, hiperactividad o agresividad) suelen ser consecuencia del desencadenar terror que, a su vez, da lugar a una conducta descontrolada. El miedo crónico es como el abusón

Cooper, Brenton G.

197

MEDIDA DE LA CSF CROMTICA Y ACROMTICA CON MONITORES ORDINARIOS PARA PRCTICAS DE LABORATORIO  

E-print Network

comerciales, de prestaciones inferiores, que presentan problemas para generar estímulos para experimentos distinguir la red de un campo uniforme. La CSF se obtiene como la inversa del contraste global en el espacio imposibilita su uso durante un experimento, por lo que trabajamos con estímulos pre-calculados. MEDIDA El

Escolano, Francisco

198

owi'3:%l OORNL/CON-75 Effect of Forced Ventilation on  

E-print Network

owi'3:%l OORNL/CON-75 Effect of Forced Ventilation on House Infiltration *CARBIDE W. P. Levins #12-eng-26 Energy Division EFFECT OF FORCED VENTILATION ON HOUSE INFILTRATION W. P. Levins DEPARTMENT 1980). v #12;EFFECT OF FORCED VENTILATION OF HOUSE INFILTRATION W. P. Levins Energy Division ABSTRACT

Oak Ridge National Laboratory

199

Iron formations are typically thinly bed-ded or laminated sedimentary rocks con-  

E-print Network

222 ABSTRACT Iron formations are typically thinly bed- ded or laminated sedimentary rocks con- taining 15% or more of iron and a large pro- portion of silica (commonly >40%). In the ca. 2590­2460 Ma Campbellrand-Kuruman Complex, Transvaal Supergroup, South Africa, iron formation occurs as a sediment- starved

Fischer, Woodward

200

UNIDAD GUADALAJARA La Unidad Guadalajara del Cinvestav se inici en noviembre de 1988 con el  

E-print Network

maestría y doctorado en la especialidad de Ingeniería Eléctrica con opción en Telecomunicaciones, y en telecomunicaciones. En su quinto año de vida, los programas académicos han seguido su camino hacia la consolidación y se encuentran ahora en la etapa de caracterización y pruebas. El grupo de telecomunicaciones

201

UNIDAD GUADALAJARA La Unidad Guadalajara del Cinvestav se inici en noviembre de 1988 con el  

E-print Network

maestría y doctorado en la especialidad de Ingeniería Eléctrica con opción en Telecomunicaciones, y en telecomunicaciones. En su cuarto año de vida, los programas académicos han seguido su camino hacia la consolidación y se encuentran ahora en la etapa de caracterización y pruebas. El grupo de telecomunicaciones

202

Percepciones y prácticas relacionadas con la tuberculosis y la adherencia al tratamiento en Chiapas, México  

Microsoft Academic Search

Objective. To identify health perceptions and practices and non-adherence to therapy among tuberculosis patients. Material and methods. Qualitative research work con- sisting of 11 group interviews with 62 tuberculosis patients during 1997-1998 in the Central, Highlands, and Border Regions of Chiapas, Mexico. Results. Perceived causes of tuberculosis included contagion via food utensils, excess work, malnutrition, and cold, as well as

Guadalupe del Carmen Alvarez-Gordillo; Julio Félix Alvarez-Gordillo; José Eugenio Dorantes-Jiménez; David Halperin-Frisch

2000-01-01

203

pag. 1S. Marsili-Libelli: Introduzione ai Fuzzy Sets Ragionamento approssimato con  

E-print Network

pag. 1S. Marsili-Libelli: Introduzione ai Fuzzy Sets Ragionamento approssimato con concetti definiti in modo vago #12;pag. 2S. Marsili-Libelli: Introduzione ai fuzzy sets E' più importante la precisione o il significato? #12;pag. 3S. Marsili-Libelli: Introduzione ai fuzzy sets Valori Crisp e Fuzzy

204

The Value of Literacy Beyond Reading: Empowering Adult Women Through Knowledge and Con...dence  

E-print Network

this knowledge. We ...nd that literacy improves knowledge of politics, health and edu- cation. As fewThe Value of Literacy Beyond Reading: Empowering Adult Women Through Knowledge and Con funded by the Social Science Research Council of Canada. 1 #12;Abstract Adult female literacy

Bandyopadhyay, Antar

205

ConMap: Investigating New Computer-Based Approaches to Assessing Conceptual Knowledge Structure in Physics.  

ERIC Educational Resources Information Center

There is a growing consensus among educational researchers that traditional problem-based assessments are not effective tools for diagnosing a student's knowledge state and for guiding pedagogical intervention, and that new tools grounded in the results of cognitive science research are needed. The ConMap ("Conceptual Mapping") project, described…

Beatty, Ian D.

206

Although most Minnesota airports do not have much concrete pavement, the con-  

E-print Network

Although most Minnesota airports do not have much concrete pavement, the con- crete they do have constructed of concrete are parking lots and sidewalks, for which the concrete is typically 4 to 6 inches thick. However, several general avi- ation airports do have concrete aprons and runways, which

Minnesota, University of

207

Research Profile Research conducted by the Polymer Technology Group is con-  

E-print Network

-conducting Organics, Polymetals MRCMaterials Research Center Crystals of a fullerene derivative growing from a glassy fundamental con- cepts for the rational design of nucleating/clarifying agents. Polymetals A new route-conducting Polymers Currently available polymer semiconductors often are brittle and environmentally relatively

Sandoghdar, Vahid

208

conStruction MAnAgeMent College of Rural and Community Development  

E-print Network

The construction management program meets growing needs in the con- struction industry by training entry to the largest of skyscrapers and industrial projects; and on rural roads to major highways. Construction principles of busi- ness and know about the technical aspects of the construction industry. Graduates

Hartman, Chris

209

DESign AnD conStruction College of Engineering and Mines  

E-print Network

in the construction industry. The program was designed in collaboration with construction industry em- ployers and continues to engage industry as a partner in the program. Engineers and other construction professionalsDESign AnD conStruction MAnAgEMEnt College of Engineering and Mines Department of Civil

Hartman, Chris

210

A Qualitative Approach to Upward Evaluation of Leadership Performance: Pros and Cons  

ERIC Educational Resources Information Center

This article describes a qualitative upward evaluation of the leadership performance of library managers. Follow-up studies were conducted, focusing on the advantages and disadvantages of the qualitative approach to upward appraisal. The authors discuss pros and cons to guide others who might use this methodology for upward appraisals in the…

Turrentine, Cathryn G.; Lener, Edward F.; Young, Michelle L.; Kok, Victoria T.

2004-01-01

211

utilization of xylooligosaccharides by this Strains of S. ruminantium varied con-  

E-print Network

and arabinose). Lactic acid was the major fermentation product formed by all strains. The ability of S, Ra or Nf. The phenolic acid con- tent of the residues and the fermented su- pematants was determined- siderably in their capacity to ferment xy- looligosaccharides prepared by partial hy- drolysis of oat spelt

Paris-Sud XI, Université de

212

A Centralized System to Access Acute Healthcare Services: The Pros and Cons  

Microsoft Academic Search

Having a centralized access service results in a daily interconnectedness between hospital sites, which can create many benefits but also much controversy. Knowing the pros and cons of a centralized service and understanding the role and work environment of the access coordinator will assist you in deciding if this service would be of benefit to your health region. In this

Susan Brown

2005-01-01

213

Onion Routing Access Con gurations Paul F. Syverson, Michael G. Reed, and David M. Goldschlag  

E-print Network

Onion Routing Access Con gurations Paul F. Syverson, Michael G. Reed, and David M. Goldschlag Naval Research Laboratory Abstract Onion Routing is an infrastructure for private com- munication over and tra c analysis. Thus it hides not only the data being sent, but who is talking to whom. Onion Routing

214

Commentary Pro\\/con ethics debate: is nonheart-beating organ donation ethically acceptable?  

Microsoft Academic Search

This pro\\/con debate explores the ethical issues surrounding nonheart-beating organ donation (NHBD), a source of considerable controversy. It is estimated that NHBD can increase the number of organs available for transplant by 25% at a time of great need. However, should NHBD be ethically acceptable? In support of NHBD, it may be acceptable practice if there is a separation of

Leslie Whetstine; Kerry Bowman; Laura Hawryluck

215

SISTEMA REMOTO DE ADQUISICIÓN PARA EL CONTROL DEL RUIDO AMBIENTAL CON FPGA Y FPAA  

Microsoft Academic Search

RESUMEN Este artículo propone el diseño de un sistema de adquisición de datos con componentes digitales y analógicos microelectrónicos reconfigurables, como son el FPGA (Field Programmable Gate Array) y el FPAA (Field Programmable Analog Array), para monitorear y analizar la contaminación por ruido ambiental. Este prototipo obtiene los datos del ruido de una zona vial (zona centro de una ciudad)

A. Castillo Atoche; J. Vázquez Castillo; V. Sanchez Huerta; P. Del Río Dawn

216

HumanWildlife Conflicts 3(1):7287, Spring 2009 Historical review of elkagriculture con-  

E-print Network

Human­Wildlife Conflicts 3(1):72­87, Spring 2009 Historical review of elk­agriculture con- flicts considerable research has focused both on documenting the direct costs of wildlife impacts on agriculture and developing economic incentives for wildlife conservation (e.g., Western et al. 1994, Nyhus et al. 2003

217

DISEÑO E IMPLEMENTACIÓN ÓPTIMA DE PERIFÉRICOS DE DSP CON SYSTEM GENERATOR PARA MICROBLAZE  

Microsoft Academic Search

Con este trabajo pretendemos analizar como se lleva a cabo el diseño de periféricos de DSP utilizando uno de los nuevos entornos de diseño de alto nivel: System Generator for DSP. Así, en este documento el objetivo es mostrar por un lado las características del entorno de diseño y las herramientas utilizadas y por otro la metodología de diseño e

J. Viejo; E. Ostua; M. J. Bellido; J. Juan; A. Millan; P. Ruiz-de-Clavijo; D. Guerrero

218

ConTrack: Finding the most likely pathways between brain regions using diffusion tractography  

E-print Network

ConTrack: Finding the most likely pathways between brain regions using diffusion tractography for measuring white matter pathways in the living human brain. DFT is often used to discover new pathways the most likely pathways between brain regions using diffusion tractography. Journal of Vision, 8(9):15, 1

Wandell, Brian A.

219

Con il patrocinio di / Sponsored by IRCCS, Santa Lucia Foundation, Roma  

E-print Network

Con il patrocinio di / Sponsored by IRCCS, Santa Lucia Foundation, Roma Sapienza University of Rome; ilaria.bufalari@gmail.com For the day of March 13th: lucia.sacheli@uniroma1.it; matteo.candidi@gmail.com #12;Monday, 11th of March Sala Congressi - Santa Lucia Foundation, IRCCS entrance via Ardeatina, 354

Di Pillo, Gianni

220

La profesora de la Universidad de Alicante Estefana Lpez, galardonada con el Premio "Estudios Financieros"  

E-print Network

Financieros" Alicante, 4 de septiembre de 2013 La profesora Estefanía López Llopis, del Departamento de "Estudios Financieros 2013 por su artículo de investigación "Las operaciones de reducción de capital con Estudios Financieros y se ha consolidado como uno de los más prestigiosos en materia de fiscalidad en

Escolano, Francisco

221

Optimizacion Continua mediante la Evolucion de Funciones de Densidad de Probabilidad con  

E-print Network

Optimizaci´on Continua mediante la Evoluci´on de Funciones de Densidad de Probabilidad con un basa en la evoluci´on de funciones de densidad de pro- babilidad, que se centran en las zonas del muestreo de individuos a partir de una densidad de probabi- lidad. En la l´inea de este algoritmo

Casillas Barranquero, Jorge

222

Optimizacion Continua mediante la Evolucion de Funciones de Densidad de Probabilidad con  

E-print Network

Optimizaci´on Continua mediante la Evoluci´on de Funciones de Densidad de Probabilidad con un basa en la evoluci´on de funciones de densidad de probabilidad, que se centran en las zonas del espa muestreo de individuos a partir de una densidad de probabilidad. En la l´inea de este algoritmo, encon

Granada, Universidad de

223

Soil protozoa as bioindicators: pros and cons, methods, diversity, representative examples  

Microsoft Academic Search

This paper emphasizes some general aspects of soil protozoa as indicators of environmental quality—pros and cons, methods, and diversity. Protozoa are at the base of the heterotrophic eukaryotic food web and an essential component in marine, freshwater, and soil ecosystems because they consume a significant portion (usually >50%) of the bacterial productivity, enhancing nutrient cycles and energy flows to the

W. Foissner

1999-01-01

224

Stability of a viscoelastic thread immersed in a con ned region # A.Y. Gunawan  

E-print Network

Stability of a viscoelastic thread immersed in a con#12;ned region # A.Y. Gunawan Departemen an in#12;nitely long viscoelastic thread in a tube #12;lled with a Newtonian uid. We apply Je#11;reys the thread is, the more time it takes to break up. A viscoelastic thread breaks up faster than a Newtonian

Eindhoven, Technische Universiteit

225

Con dence regions for spectral peak frequencies , M. Lauk1;2  

E-print Network

Con dence regions for spectral peak frequencies J. Timmer1 , M. Lauk1;2 and C.H. Lucking2 1 Zentrum al., 1987; Beuter and De Geof- froy, 1996; Pinna, Maestri, Di Cesare, 1996; Khutorskaya and Fjodorova to tremor data is given in Section 5. 2 Spectral estimation The spectrum S(!)!2(? ; ) of a stationary

Timmer, Jens

226

Ai partecipanti verr rilasciato un attestato di partecipazione Partecipazione libera con pre-iscrizione obbligatoria online  

E-print Network

-iscrizione obbligatoria online sul sito: http://social-media-marketing-day.web-marketing-manager.it/nuove- figure) Università degli Studi di Milano Social Media Marketing Day Social media e digital: Nuove figure comununicazione d'impresa - Le 30 discipline del Web e Digital Market Manager Incontro con Andrea Albanese Docente

De Cindio, Fiorella

227

Enrichment of Glycoproteins using Nano-scale Chelating Con A Monolithic Capillary Chromatography  

PubMed Central

Immobilized lectin chromatography can be employed for glycoprotein enrichment, but commonly used columns have limitations of yield and resolution. In order to improve efficiency and to make the technique applicable to minimal sample material, we have developed a nano-scale chelating Concanavalin A (Con A) monolithic capillary prepared using GMA-EDMA (glycidyl methacrylate–co-ethylene dimethacrylate) as polymeric support. Con A was immobilized on Cu(II)-charged iminodiacetic acid (IDA) regenerable sorbents by forming a IDA:Cu(II):Con A sandwich affinity structure that has high column capacity as well as stability. When compared with conventional Con A lectin chromatography, the monolithic capillary enabled the better reproducible detection of over double the number of unique N-glycoproteins in human urine samples. Utility for analysis of minimal biological samples was confirmed by the successful elucidation of glycoprotein profiles in mouse urine samples at the microliter scale. The improved efficiency of the nano-scale monolithic capillary will impact the analysis of glycoproteins in complex biological samples, especially where only limited material may be available. PMID:19366252

Feng, Shun; Yang, Na; Pennathur, Subramaniam; Goodison, Steve; Lubman, David M.

2009-01-01

228

Beneficios del ejercicio físico en los pacientes con diabetes Benefits of exercise in patients with diabetes  

Microsoft Academic Search

Physical exercise has important health benefi ts. Physical inactivity is as- sociated with an increased risk of chronic diseases like type 2 diabetes mellitus. In contrast, moderate levels of physical exercise produce con- siderable benefi ts in diabetic patients, especially in those with type 2 dia- betes mellitus. At the onset of the disease, modifi cation of lifestyle, with improvements

Á. Caballero Figueroa; M. Hernández García

229

Mandated Mental Health Insurance: A Complex Case of Pros and Cons. Human Resources Series.  

ERIC Educational Resources Information Center

The pros and cons of state laws mandating mental health insurance are discussed in this report. The history of a 1985 Supreme Court case which held that states could mandate mental health benefits introduces the report. In an overview of the issue, the long-standing argument between the insurance industry and the mental health establishment is…

Paterson, Andrea

1986-01-01

230

phosphorylation at these sites, disrupted effects of glucose on CRTC2 activity in hepatocytes, con-  

E-print Network

regulators may improve glucose homeostasis and reduce long-term complications associated with this diseasephosphorylation at these sites, disrupted effects of glucose on CRTC2 activity in hepatocytes, con- firming the importance of these sites for transcrip- tional regulation in response to glucose (Fig. 3D). O

Nizet, Victor

231

Arctic & Antarctic Regions : referencias de artculos de revistas (algunos a texto completo), con  

E-print Network

· Arctic & Antarctic Regions : referencias de artículos de revistas (algunos a texto completo), con 1800 · REDALYC : hemeroteca en línea de los avances científicos en Iberoamérica. · Arctic & Antarctic

Autonoma de Madrid, Universidad

232

Accesibilidad para personas con debilidad visual Mac OS X Snow Leopard  

E-print Network

Accesibilidad para personas con debilidad visual Mac OS X Snow Leopard ASIC ­ 18 de noviembre de LEOPARD Al igual que otros sistemas operativos, MAC OS X Snow Leopard ofrece algunas ayudas para que las debilidad visual Mac OS X Snow Leopard ASIC ­ 18 de noviembre de 2010 Pág. 2 de 25 1. Recomendaciones

Fernández de Córdoba, Pedro

233

I JORNADAS SOBRE TRASTORNO DE DFICIT DE ATENCIN CON/SIN HIPERACTIVIDAD. CONOCIENDO EL  

E-print Network

I JORNADAS SOBRE TRASTORNO DE D�FICIT DE ATENCI�N CON/SIN HIPERACTIVIDAD. CONOCIENDO EL TDAH PARA alumnos que presentan TDAH tienen capacidad para adquirir nuevos conocimientos, pero su dificultad radica. "Conociendo el TDAH": Origen, signos de alerta, diagnóstico, evaluación, tratamiento. Ponente: Dra. Mara

Rey Juan Carlos, Universidad

234

which settles the debate about the exclusiveness of memory con-solidation during sleep.  

E-print Network

which settles the debate about the exclusiveness of memory con- solidation during sleep. In describing the findings regarding procedural memory and sleep in humans, Walker states that the evidence & Born 1999a]) as well as different manipulation techniques (e.g., early versus late sleep [Plihal & Born

235

GENERACION DE REGLAS DIFUSAS CON BUEN NIVEL DE COOPERACION MEDIANTE ALGORITMOS DE HORMIGAS  

E-print Network

´etodos suelen estar basados en algoritmos de aprendizaje muy costosos en tiempo, tales como los Algoritmos Gen´eticosGENERACI´ON DE REGLAS DIFUSAS CON BUEN NIVEL DE COOPERACI´ON MEDIANTE ALGORITMOS DE HORMIGAS Jorge un nuevo pa- radigma de algoritmos bioinspirados, los al- goritmos de Optimizaci´on mediante Colonias

Casillas Barranquero, Jorge

236

TITLE: Shifting Agrarian Landscapes: Climate Change and Adaptation in Bangladesh HOSTS: Jason Cons and Shelley Feldman  

E-print Network

TITLE: Shifting Agrarian Landscapes: Climate Change and Adaptation in Bangladesh HOSTS: Jason Cons by exploring the micro-processes of adaptation and survival in four villages in Bangladesh. Specifically them to their daily lives and production practices? Second, what strategies of adaptation are rural

Angenent, Lars T.

237

Adsornftl 8~f^Ll* ORNL/CON-155 O173IS1o COp  

E-print Network

of Stirling Engine Thermodynamics N. C. J. Chen F. P. Griffin C. D. West OPERATED BY TAHP *MARTIN MARIETTA Government or any agency thereof. #12;ORNL/CON-155 LINEAR HARMONIC ANALYSIS OF STIRLING ENGINE THERMODYNAMICS ................... 8 2.3 Integrated Energy Equations ......................... 11 2.4 Engine Performance Parameters

Oak Ridge National Laboratory

238

Integrated Concentration in Science, 2012 High Fructose Corn Syrup a mini iCons case study  

E-print Network

© Integrated Concentration in Science, 2012 High Fructose Corn Syrup­ a mini iCons case study researchers find that high fructose corn syrup prompts considerably more weight gain. http://www.princeton.edu/main/news/archive/S26/91/22K07/ The Atlantic, Aug 13, 2012 ­ Study: High fructose corn syrup no worse than `real' sugar

Auerbach, Scott M.

239

ANÁLISIS PRELIMINAR DE COMPUESTOS FENÓLICOS Y CAPSAICINOIDES EN VARIEDADES DE CHILE CON DIFERENTE CAPACIDAD PUNGENTE  

Microsoft Academic Search

El chile jalapeño provoca un alto nivel de irritación a diferentes niveles del tracto estomacal en comparación con el chile habanero. A pesar de que el chile habanero presenta una mayor capacidad pungente, no es irritante. A la fecha se desconoce la naturaleza de los compuestos responsables de este efecto. En el presente trabajo se reporta el análisis preliminar de

Salvador Horacio; Guzmán Maldonado; Irineo Torres Pacheco; Mario González Chavira; María Alejandra; Mora Avilés; Guadalupe Herrera Hernández; David Hernández López

240

The environmental impact of supplying power to the Con Edison service territory: 1975--1990  

Microsoft Academic Search

A description is given of present and anticipated environmental consequences of meeting electricity demand in the Con Edison service territory--New York City and most of Westchester County. Important issues include nuclear power, air pollution, water and aquatic life, and siting power plants and transmission facilities. (GRA)

A. K. Freedman; J. C. Cohen

1975-01-01

241

22 Wisconsin Natural Resources These are all good ways to con-  

E-print Network

water purification and replenish- ing the water table. To supply our drinking water, we withdraw22 Wisconsin Natural Resources These are all good ways to con- serve water but are only part of your water conservation opportu- nity. These practices focus on water demand as it relates to drawing

Saldin, Dilano

242

Manual de uso de la Pasarela conCIENCIA > Digital.CSIC (versin 2.2)  

E-print Network

datos de producción científica institucional y gestionar los trasvases al repositorio de un modo producción de su centro o instituto cargada en conCIENCIA que desee trasvasar al repositorio institucional accesible solamente a la comunidad bibliotecaria del CSIC y los administradores del repositorio que sirve

243

Aplicación de técnicas de usabilidad con inclusión en la Fase de Análisis de Requisitos  

Microsoft Academic Search

En este artículo se presenta un caso práctico de utilización de técnicas de usabilidad con inclusión en la Fase de Análisis de requisitos en el ciclo de desarrollo Web siguiendo una metodología de Diseño Centrado en el Usuario. Como caso práctico, se va a mostrar la aplicación de técnicas cómo Perfiles de Usuario, Persona, Escenarios y Card Sorting como soporte

Lourdes Moreno; Paloma Martinez; Belen Ruiz

244

Optimizing Electrospray Interfaces Using Slowly Diverging Conical Duct (ConDuct) Electrodes.  

PubMed

We demonstrate that the efficiency of ion transmission from atmosphere to vacuum through stainless steel electrodes that contain slowly divergent conical duct (ConDuct) channels can be close to 100%. Here, we explore the properties of 2.5-cm-long electrodes with angles of divergence of 0°, 1°, 2°, 3°, 5°, 8°, 13°, and 21°, respectively. The ion transmission efficiency was observed to jump from 10-20% for the 0° (straight) channels to 90-95% for channels with an angle of divergence as small as 1°. Furthermore, the 2-3° ConDuct electrodes produced extraordinarily low divergence ion beams that propagated in a laser-like fashion over long distances in vacuum. To take advantage of these newly discovered properties, we constructed a novel atmosphere-to-vacuum ion interface utilizing a 2° ConDuct as an inlet electrode and compared its ion transmission efficiency with that of the interface used in the commercial (Thermo Fisher Scientific, San Jose, CA, USA) Velos Orbitrap and Q Exactive mass spectrometers. We observed that the ConDuct interface transmitted up to 17 times more ions than the commercial reference interface and also yielded improved signal-to-noise mass spectra of peptides. We infer from these results that the performance of many current atmosphere-to-vacuum interfaces utilizing metal capillaries can be substantially improved by replacing them with 1° or 2° metal ConDuct electrodes, which should preserve the convenience of supplying ion desolvation energy by heating the electrode while greatly increasing the efficiency of ion transmission into the mass spectrometer. PMID:25667060

Krutchinsky, Andrew N; Padovan, Júlio C; Cohen, Herbert; Chait, Brian T

2015-04-01

245

Optimizing Electrospray Interfaces Using Slowly Diverging Conical Duct (ConDuct) Electrodes  

NASA Astrophysics Data System (ADS)

We demonstrate that the efficiency of ion transmission from atmosphere to vacuum through stainless steel electrodes that contain slowly divergent conical duct (ConDuct) channels can be close to 100%. Here, we explore the properties of 2.5-cm-long electrodes with angles of divergence of 0°, 1°, 2°, 3°, 5°, 8°, 13°, and 21°, respectively. The ion transmission efficiency was observed to jump from 10-20% for the 0° (straight) channels to 90-95% for channels with an angle of divergence as small as 1°. Furthermore, the 2-3° ConDuct electrodes produced extraordinarily low divergence ion beams that propagated in a laser-like fashion over long distances in vacuum. To take advantage of these newly discovered properties, we constructed a novel atmosphere-to-vacuum ion interface utilizing a 2° ConDuct as an inlet electrode and compared its ion transmission efficiency with that of the interface used in the commercial (Thermo Fisher Scientific, San Jose, CA, USA) Velos Orbitrap and Q Exactive mass spectrometers. We observed that the ConDuct interface transmitted up to 17 times more ions than the commercial reference interface and also yielded improved signal-to-noise mass spectra of peptides. We infer from these results that the performance of many current atmosphere-to-vacuum interfaces utilizing metal capillaries can be substantially improved by replacing them with 1° or 2° metal ConDuct electrodes, which should preserve the convenience of supplying ion desolvation energy by heating the electrode while greatly increasing the efficiency of ion transmission into the mass spectrometer.

Krutchinsky, Andrew N.; Padovan, Júlio C.; Cohen, Herbert; Chait, Brian T.

2015-02-01

246

Optimizing Electrospray Interfaces Using Slowly Diverging Conical Duct (ConDuct) Electrodes  

NASA Astrophysics Data System (ADS)

We demonstrate that the efficiency of ion transmission from atmosphere to vacuum through stainless steel electrodes that contain slowly divergent conical duct (ConDuct) channels can be close to 100%. Here, we explore the properties of 2.5-cm-long electrodes with angles of divergence of 0°, 1°, 2°, 3°, 5°, 8°, 13°, and 21°, respectively. The ion transmission efficiency was observed to jump from 10-20% for the 0° (straight) channels to 90-95% for channels with an angle of divergence as small as 1°. Furthermore, the 2-3° ConDuct electrodes produced extraordinarily low divergence ion beams that propagated in a laser-like fashion over long distances in vacuum. To take advantage of these newly discovered properties, we constructed a novel atmosphere-to-vacuum ion interface utilizing a 2° ConDuct as an inlet electrode and compared its ion transmission efficiency with that of the interface used in the commercial (Thermo Fisher Scientific, San Jose, CA, USA) Velos Orbitrap and Q Exactive mass spectrometers. We observed that the ConDuct interface transmitted up to 17 times more ions than the commercial reference interface and also yielded improved signal-to-noise mass spectra of peptides. We infer from these results that the performance of many current atmosphere-to-vacuum interfaces utilizing metal capillaries can be substantially improved by replacing them with 1° or 2° metal ConDuct electrodes, which should preserve the convenience of supplying ion desolvation energy by heating the electrode while greatly increasing the efficiency of ion transmission into the mass spectrometer.

Krutchinsky, Andrew N.; Padovan, Júlio C.; Cohen, Herbert; Chait, Brian T.

2015-04-01

247

SweConsNet'02 The 1st SweConsNet Workshop Pierre Flener and Justin Pearson, ASTRA, Uppsala Univ. Page 1 of 19 Relational Modelling of CSPs  

E-print Network

SweConsNet'02 ­ The 1st SweConsNet Workshop Pierre Flener and Justin Pearson, ASTRA, Uppsala Univ Flener and Justin Pearson, ASTRA, Uppsala Univ. Page 2 of 19 Members · Dr Pierre Flener, Department of Information Technology, principal investigator · Dr Justin Pearson, Department of Information Technology · Mr

Flener, Pierre

248

Appeared in ASPLOS-VI Proceedings, Oct 1994 1 Dynamic Memory Disambiguation Using the Memory Con ict Bu er  

E-print Network

Appeared in ASPLOS-VI Proceedings, Oct 1994 1 Dynamic Memory Disambiguation Using the Memory Con store load depen- dences. Correct program execution is ensured by the memory con ict bu er and repair scheduling model can be achieved for both non-numerical and numerical programs. 1 Introduction A compile

Hwu, Wen-mei W.

249

A brief guide to access the Wound Healing and Management (WHAM) Node via JBI COnNECT+  

E-print Network

A brief guide to access the Wound Healing and Management (WHAM) Node via JBI COnNECT+ To access JBI COnNECT+ and the Wound Healing and Management Node go to JBI Homepage at http and password are both the same word: - wound. #12; To go directly to the Wound Healing and Management Node

250

HOUSing Study / By Urs Buehlmann. Matt Bumgardner and Kar en Koenig rends in housing and other con  

E-print Network

in housing and other con struction-related sectors continue to have a significant impact on the wood products year. Con ducted in early 2014, the study is a joint effort by Virginia Tech, the U.S. Forest Service and Wood Products. (See more information about the survey, page 64.) Housing Market Analysis Overall

251

Apoyo financiero La Universidad de los Andes cuenta con un plan de asistencia financiera que les permite a los  

E-print Network

Apoyo financiero La Universidad de los Andes cuenta con un plan de asistencia financiera que les, Los Andes cuenta con una unidad (Oficina de Apoyo Financiero) que brinda información, asesoría, apoyo la Universidad. Ir al sitio web de Apoyo Financiero 1 / 2 #12;Apoyo financiero {ifactum2menu id=509

Amézquita, Adolfo

252

FORMALISM ALE ALEP CL-ONE ConTroll CUF TDL ProFIT TFS Type system  

E-print Network

(2) FORMALISM ALE ALEP CL-ONE ConTroll CUF TDL ProFIT TFS Type system multiple inheritance yes;(3) COMPUTATION ALE ALEP CL-ONE ConTroll CUF TDL ProFIT TFS Algorithmic issues parsing PS-based PS-based PS

Branco, António Horta

253

Añadir quimioterapia después de la radioterapia mejora la supervivencia de adultos con un tipo de tumor cerebral de crecimiento lento  

Cancer.gov

Adultos con gliomas de grado bajo, una forma de tumor cerebral, que recibieron tratamiento con quimioterapia después de la radioterapia vivieron más tiempo que pacientes que recibieron solo radioterapia, según los resultados de seguimiento a largo plazo de un estudio clínico aleatorizado y controlado, subvencionado por los NIH.

254

JULY–SEPTEMBER 2013 VIRGINIA LIBRARIES PAGE 21 We Put On a Comic-Con (And So Can You!)  

E-print Network

for fans of comic books, graphic novels, manga, anime, and science fiction to gather and enjoy, discuss, learn about, and participate in the dissemination of information about their interests. (“Con ” is a shortened form of fan convention.) ow many of you have been in meetings when an idea was proposed that garnered nearly universal support? It may not happen often, but that was the response when we proposed that Chesterfield County Public Library (CCPL) have a comic-con of its very own. A comic-con may seem like a strange fit for a library. People may think of comic books as an inferior form of literature, or not as literature at all, and they may think of a comic-con as a commercial enterprise (which it can be, but often isn’t). The most famous comic-con, popularly known as the Comic-Con, is the International Comic-Con: San Diego. Started in 1970, it has since grown to draw upwards of 13,000 people, and features superstar creators and authors of the comic, sci-fi, and fantasy world. 1 H At Chesterfield County Public Library, we felt that a comic-con would align well with our mission of transforming information into knowledge, and would help us achieve some powerful goals. We wanted to share the importance and impact of graphic novels and comic books on literacy and the validity of their inclusion in a public library materials collection. After attending a presentation at Virginia Library Association

Kate Denwiddie; Kareemah Hamdan

255

Probing of Brain States in Real-Time: Introducing the ConSole Environment  

PubMed Central

Recent years have seen huge advancements in the methods available and used in neuroscience employing EEG or MEG. However, the standard approach is to average a large number of trials for experimentally defined conditions in order to reduce intertrial-variability, i.e., treating it as a source of “noise.” Yet it is now more and more accepted that trial-to-trial fluctuations bear functional significance, reflecting fluctuations of “brain states” that predispose perception and action. Such effects are often revealed in a pre-stimulus period, when comparing response variability to an invariant stimulus. However such offline analyses are disadvantageous as they are correlational by drawing conclusions in a post hoc-manner and stimulus presentation is random with respect to the feature of interest. A more direct test is to trigger stimulus presentation when the relevant feature is present. The current paper introduces Constance System for Online EEG (ConSole), a software package capable of analyzing ongoing EEG/MEG in real-time and presenting auditory and visual stimuli via internal routines. Stimulation via external devices (e.g., transcranial magnetic stimulation) or third-party software (e.g., PsyScope X) is possible by sending TTL-triggers. With ConSole it is thus possible to target the stimulation at specific brain states. In contrast to many available applications, ConSole is open-source. Its modular design enhances the power of the software as it can be easily adapted to new challenges and writing new experiments is an easy task. ConSole is already pre-equipped with modules performing standard signal processing steps. The software is also independent from the EEG/MEG system, as long as a driver can be written (currently two EEG systems are supported). Besides a general introduction, we present benchmark data regarding performance and validity of the calculations used, as well as three example applications of ConSole in different settings. ConSole can be downloaded at: http://console-kn.sf.net. PMID:21716603

Hartmann, Thomas; Schulz, Hannah; Weisz, Nathan

2011-01-01

256

Order effect y presencia de erratas en estudios de usuarios con eye tracking  

E-print Network

evitarse en el diseño de experimentos que impliquen lectura, especialmente si se aplican métricas de eye. Estudios de usuarios. Test de usuarios. Tareas. Diseño de experimentos. Sesgos 1. INTRODUCCI�N Los estudios, su cultura, etc.), y otros están relacionados con el propio diseño del experimento (la redacción de

257

Administracin Nacional de Aeronutica y del Espacio Descubra la relacin que tiene el espacio con usted  

E-print Network

los océanos Remedios contra la contaminación ambiental Control de corrosión en represas y puentes sistema de tratamiento de aguas negras, el cual protege el medio ambiente. ¿Y quién no querría puentes y corrosión en puentes, represas y otras estructuras. Si usted pasa tiempo en la playa, allí está la NASA con

258

The International Consortium for the Investigation of Renal Malignancies (I-ConFIRM)  

Cancer.gov

I-ConFIRM (The International Consortium for the Investigation of Renal Malignancies) was formed in 2013 to promote international, multidisciplinary collaborations to advance our understanding of the etiology and outcomes of kidney cancer. The Consortium is comprised of international investigators and clinicians who have ongoing or completed studies relating to kidney cancer. In its initial phase, the Consortium will undertake research projects that pool existing data across studies as well as developing other collaborative research projects.

259

ConSurf 2005: the projection of evolutionary conservation scores of residues on protein structures  

Microsoft Academic Search

Key amino acid positions that are important for main- taining the 3D structure of a protein and\\/or its func- tion(s), e.g. catalytic activity, binding to ligand, DNA or other proteins, are often under strong evolutionary constraints. Thus, the biological importance of a residue often correlates with its level of evolution- ary conservation within the protein family. ConSurf (http:\\/\\/consurf.tau.ac.il\\/) is a

Meytal Landau; Itay Mayrose; Yossi Rosenberg; Fabian Glaser; Eric Martz; Tal Pupko; Nir Ben-tal

2005-01-01

260

Pro\\/con ethics debate: is nonheart-beating organ donation ethically acceptable?  

Microsoft Academic Search

This pro\\/con debate explores the ethical issues surrounding nonheart-beating organ donation (NHBD), a source of considerable\\u000a controversy. It is estimated that NHBD can increase the number of organs available for transplant by 25% at a time of great\\u000a need. However, should NHBD be ethically acceptable? In support of NHBD, it may be acceptable practice if there is a separation\\u000a of

Leslie Whetstine; Kerry Bowman; Laura Hawryluck

2002-01-01

261

tas. Siempre con el apoyo de Minitab y poniendo el nfasis en la claridad de la  

E-print Network

desean revitali- zarlo. Lean Six Sigma es una metodología de me- jora cuyo objetivo es hacer que las Mejora Lean Six Sigma Nivel Black Belt está estructu- rado para proporcionar a sus participantes las implantación con éxito de programas Lean Six Sigma. · Metodología: en el que se detallan las ac- tividades

Politècnica de Catalunya, Universitat

262

The ConSurf-HSSP database: The mapping of evolutionary conservation among homologs onto PDB structures  

Microsoft Academic Search

The HSSP (Homology-Derived Sec- ondary Structure of Proteins) database provides multiple sequence alignments (MSAs) for proteins of known three-dimensional (3D) structure in the Protein Data Bank (PDB). The database also con- tains an estimate of the degree of evolutionary conservation at each amino acid position. This esti- mate, which is based on the relative entropy, corre- lates with the functional

Fabian Glaser; Yossi Rosenberg; Amit Kessel; Tal Pupko; Nir Ben-Tal

2005-01-01

263

Disfrute del sol con cuidado -- Cualquier persona puede padecer cáncer de piel  

Cancer.gov

Está bien pasar algún tiempo al aire libre, pero usted debe saber que las personas de piel más oscura –incluso muchos hispanos o latinos– tienen riesgo de padecer cáncer de piel. Siempre que pueda, evite exponerse al sol, especialmente entre las 10 a.m. y las 4 p.m., cuando los rayos del sol son más fuertes. Si trabaja o juega al aire libre, cúbrase y protéjase la piel con prendas de vestir, sombreros, lentes, filtros solares.

264

Valutazione delle aree delaminate in strutture edili fibrorinforzate, con il metodo termico  

Microsoft Academic Search

SOMMARIO La recente normativa internazionale ed italiana relativa al consolidamento statico di opere civili con materiali compositi fibrorinfozati fornisce dati quantitativi precisi sul numero ed estensione massima ammissibile delle aree distaccate. Purtroppo, la tipologia delle prove previste contempla quelle non distrutive solo in modo complementare, finalizzate essenzialmente alla verifica dell'uniformità dell'applicazione. L'assenza di un'affidabile procedura di controllo in grado di

E. Grinzato; R. Trentin; P. G. Bison; S. Marinetti; M. R. Valluzzi

265

Demystifying 3D ICs: The Pros and Cons of Going Vertical  

Microsoft Academic Search

This article provides a practical introduction to the design trade-offs of the currently available 3D IC technology options. It begins with an overview of techniques, such as wire bonding, microbumps, through vias, and contactless interconnection, comparing them in terms of vertical density and practical limits to their use. We then present a high-level discussion of the pros and cons of

W. Rhett Davis; John Wilson; Stephen Mick; Jian Xu; Hao Hua; Christopher Mineo; Ambarish M. Sule; Michael Steer; Paul D. Franzon

2005-01-01

266

The pros and cons of endovascular and open surgical treatments for patients with acute limb ischemia.  

PubMed

The present review addresses the pros and cons of the current, wide variety of therapeutic options available for the treatment of acute limb ischemia (ALI). Despite five prospective randomized controlled trials comparing catheter directed thrombolysis and open surgical revascularization, no single treatment strategy can yet be considered optimal for patients with ALI. This report includes 20 years of published data to evaluate the efficacy and safety profile of thrombolytic agents and adjunctive endovascular techniques when compared to open surgical revascularization. PMID:25573443

Branco, B C; Montero-Baker, M F; Mills, J L

2015-06-01

267

Structure, stratigraphy and petroleum geology of the south east Nam Con Son Basin, offshore Vietnam  

SciTech Connect

Recent exploration of the south east Nam Con Son Basin, offshore Vietnam, by BP in alliance with Statoil has involved acquisition of new seismic and well data. These new data have allowed re-evaluation of the tectono-stratigraphic development and petroleum geology, and have provided additional constraints on the regional tectonic evolution. The offshore Vietnamese basins have evolved in response to the complex relative motions of Indochina, Peninsular Malaysia, Borneo and the South China Sea during the Cenozoic. On the regional scale these motions have been accommodated by strike-slip fault development, rifting and contraction. In the Nam Con Son Basin these motions have interacted in different ways from the Palaeogene to recent. Two rifting episodes are recognized; a Palaeogene phase dominated by E-W trending extensional faults, and a Miocene phase dominated by N-S to NE-SW trending faults. The structural evolution is complicated by a pulse of mild contraction during the Middle Miocene. The sedimentary fill of the basin evolves from continental fluvio-lacustrine in the Palaeogene through to fully marine following the second phase of rifting in the Miocene. This pulsed structural and stratigraphic evolution has resulted in basinwide deposition of source, reservoir and seal facies, and produced a variety of potential trapping styles. This paper describes the hydrocarbon habitat of the south east Nam Con Son Basin within the context of the regional tectono-stratigraphic model.

Fraser, A.J.; Matthews, S.J.; Lowe, S.; Todd, S.P.; Simon, P. Peel, F.J. [BP Exploration Operating Co., Ltd., Uxbridge (United Kingdom)

1996-12-31

268

Structure, stratigraphy and petroleum geology of the south east Nam Con Son Basin, offshore Vietnam  

SciTech Connect

Recent exploration of the south east Nam Con Son Basin, offshore Vietnam, by BP in alliance with Statoil has involved acquisition of new seismic and well data. These new data have allowed re-evaluation of the tectono-stratigraphic development and petroleum geology, and have provided additional constraints on the regional tectonic evolution. The offshore Vietnamese basins have evolved in response to the complex relative motions of Indochina, Peninsular Malaysia, Borneo and the South China Sea during the Cenozoic. On the regional scale these motions have been accommodated by strike-slip fault development, rifting and contraction. In the Nam Con Son Basin these motions have interacted in different ways from the Palaeogene to recent. Two rifting episodes are recognized; a Palaeogene phase dominated by E-W trending extensional faults, and a Miocene phase dominated by N-S to NE-SW trending faults. The structural evolution is complicated by a pulse of mild contraction during the Middle Miocene. The sedimentary fill of the basin evolves from continental fluvio-lacustrine in the Palaeogene through to fully marine following the second phase of rifting in the Miocene. This pulsed structural and stratigraphic evolution has resulted in basinwide deposition of source, reservoir and seal facies, and produced a variety of potential trapping styles. This paper describes the hydrocarbon habitat of the south east Nam Con Son Basin within the context of the regional tectono-stratigraphic model.

Fraser, A.J.; Matthews, S.J.; Lowe, S.; Todd, S.P.; Simon, P. Peel, F.J. (BP Exploration Operating Co., Ltd., Uxbridge (United Kingdom))

1996-01-01

269

ConPADE: Genome Assembly Ploidy Estimation from Next-Generation Sequencing Data  

PubMed Central

As a result of improvements in genome assembly algorithms and the ever decreasing costs of high-throughput sequencing technologies, new high quality draft genome sequences are published at a striking pace. With well-established methodologies, larger and more complex genomes are being tackled, including polyploid plant genomes. Given the similarity between multiple copies of a basic genome in polyploid individuals, assembly of such data usually results in collapsed contigs that represent a variable number of homoeologous genomic regions. Unfortunately, such collapse is often not ideal, as keeping contigs separate can lead both to improved assembly and also insights about how haplotypes influence phenotype. Here, we describe a first step in avoiding inappropriate collapse during assembly. In particular, we describe ConPADE (Contig Ploidy and Allele Dosage Estimation), a probabilistic method that estimates the ploidy of any given contig/scaffold based on its allele proportions. In the process, we report findings regarding errors in sequencing. The method can be used for whole genome shotgun (WGS) sequencing data. We also show applicability of the method for variant calling and allele dosage estimation. Results for simulated and real datasets are discussed and provide evidence that ConPADE performs well as long as enough sequencing coverage is available, or the true contig ploidy is low. We show that ConPADE may also be used for related applications, such as the identification of duplicated genes in fragmented assemblies, although refinements are needed. PMID:25880203

Margarido, Gabriel R. A.; Heckerman, David

2015-01-01

270

Mound-ACT*DE*CON{sup SM} feasibility study. Phase 2: Final report  

SciTech Connect

A portion of the abandoned Miami-Erie Canal paralleling the Greater Miami River receives the runoff and storm-water discharge from Mound Laboratory. In 1969, a low-level plutonium leak contaminated sediment as far away as 1.5 mi from the Mound site along the old canal system. An estimated one million cubic feet of sediment requires remediation. The technology being evaluated for the remediation of the low-level plutonium-238 contamination of the sediment involves two processes: washing the sediments with ACT*DE*CON{sup SM} solution to dissolve the contaminant, followed by extraction of the solution and processing with the MAG*SEP{sup SM} process to concentrate the contaminant and allow reuse of the ACT*DE*CON{sup SM} solution. The processes are being optimized for pilot-scale and field demonstration. Phase 2 of the project primarily involved identification at the laboratory scale of the optimal ACT*DE*CON{sup SM} formulation, identification of the ion-exchanger and MAG*SEP{sup SM} particles, verification of the plutonium mobility in the treated soil, and evaluation of other process parameters according to a series of tasks.

NONE

1994-12-01

271

COMUNICATO STAMPA Protocollo di intesa tra Universit degli Studi di Salerno e ONG Medici con l'Africa CUAMM: domani la firma  

E-print Network

COMUNICATO STAMPA Protocollo di intesa tra Università degli Studi di Salerno e ONG Medici con l che domani, 25 luglio, sarà siglato tra l'Università degli Studi di Salerno e l'ONG Medici con l - "testimonia la ferma volontà dell'Università di Salerno di contribuire, unitamente alla ONG Medici con l

Costagliola, Gennaro

272

40 CFR 180.1213 - Coniothyrium minitans strain CON/M/91-08; exemption from the requirement of a tolerance.  

Code of Federal Regulations, 2010 CFR

...2010-07-01 false Coniothyrium minitans strain CON/M/91-08; exemption from the...180.1213 Coniothyrium minitans strain CON/M/91-08; exemption from the...microbial pesticide Coniothyrium minitans strain CON/M/91-08 when used in or on...

2010-07-01

273

32 Wesley C. Salmon -it has been appropriate to deny that such appeals to functions involve the con-  

E-print Network

32 Wesley C. Salmon -it has been appropriate to deny that such appeals to functions involve the con's (1962) defense of deductive explanation in her contribution to the third volume #12;34 Wesley C. Salmon

Fitelson, Branden

274

The Credibility Revolution in Empirical Economics: How Better Research Design is Taking the Con out of Econometrics  

E-print Network

Just over a quarter century ago, Edward Leamer (1983) reflected on the state of empirical work in economics. He urged empirical researchers to “take the con out of econometrics” and memorably observed (p. 37): “Hardly ...

Angrist, Joshua

2010-01-01

275

Timing and Tectonic implications of basin inversion in the Nam Con Son Basin and adjacent areas, southern South China Sea  

E-print Network

The Nam Con Son (NCS) Basin, located offshore of SE Vietnam, is one of several Tertiary rift basins that formed during initial Eocene(?)-Oligocene rifting. Following cessation of rifting at the end of Oligocene time, these basins were subjected...

Olson, Christopher Charles

2001-01-01

276

Extenso estudio realizado en muchos centros demuestra que hay una precisión comparable de la colonoscopia virtual con la colonoscopia convencional  

Cancer.gov

Según los resultados del Estudio Nacional de Colografía de Tomografía Computarizada de la American College of Radiology Imaging Network, ACRIN, la colografía de tomografía computarizada, también conocida como colonoscopia virtual, es comparable a la colonoscopia convencional en su capacidad para detectar con precisión cáncer y pólipos precancerosos y podría servir como examen selectivo inicial de detección de cáncer colorrectal. La colonoscopia convencional usa un tubo largo, flexible, con cámara, para ver el revestimiento del colon.

277

Presentación del estudio "Links" de hombres que tienes sexo con hombres en Buenos Aires, Argentina.  

PubMed

Estudios previos en Buenos Aires reportaron altas prevalencias de HIV entre HSH, con valores que oscilan entre 9 y 14% durante casi 10 años de continuo testeo. El objetivo principal de este estudio fue la evaluación de factores relacionados al comportamiento de alto riesgo para transmisión del HIV entre HSH entre los que se incluyen el conocimiento y factores emocionales, socioculturales y ambientales. Por otro lado se realizó la estimación de prevalencia e incidencia de HIV utilizando RDS (Respondent Driven Sampling), así como la presencia de otras infecciones de transmisión sexual. Por último se evaluaron los hábitos de testeo para HIV indagando que factores facilitan o impiden su realización. El estudio constó de dos fases, en primer lugar una fase cualitativa y posteriormente una fase cuantitativa con una duración total de 4 años y medio. Durante la fase cualitativa se realizaron 44 entrevistas individuales en profundidad, 8 grupos focales y 10 observaciones etnográficas (hoteles, baños públicos ("teteras"), cines pornográficos, fiestas privadas, dark rooms y discotecas). Durante la fase cuantitativa del estudio se realizó el reclutamiento de 500 participantes que provinieron de la Ciudad Autónoma de Buenos Aires, así como del Gran Buenos Aires. El reclutamiento se comenzó con 16 participantes llamados semillas. Se realizó el diagnóstico de infección por HIV, hepatitis B y C (HBV y HCV), Treponema pallidum, Virus Papiloma Humano (HPV) y Chlamidias. La colaboración establecida entre los grupos de trabajo enfocados en áreas diversas posibilitó el abordaje conjunto de nuevas estrategias de investigación antes no exploradas en nuestro país. Los resultados más relevantes de esta investigación serán progresivamente publicados en sucesivos números de Actualizaciones en SIDA. PMID:25264397

Carballo-Diéguez, Alex; Avila, María M; Balán, Iván C; Marone, Rubén; Pando, María A; Barreda, Victoria

2011-03-01

278

Presentación del estudio “Links” de hombres que tienes sexo con hombres en Buenos Aires, Argentina  

PubMed Central

Resumen Estudios previos en Buenos Aires reportaron altas prevalencias de HIV entre HSH, con valores que oscilan entre 9 y 14% durante casi 10 años de continuo testeo. El objetivo principal de este estudio fue la evaluación de factores relacionados al comportamiento de alto riesgo para transmisión del HIV entre HSH entre los que se incluyen el conocimiento y factores emocionales, socioculturales y ambientales. Por otro lado se realizó la estimación de prevalencia e incidencia de HIV utilizando RDS (Respondent Driven Sampling), así como la presencia de otras infecciones de transmisión sexual. Por último se evaluaron los hábitos de testeo para HIV indagando que factores facilitan o impiden su realización. El estudio constó de dos fases, en primer lugar una fase cualitativa y posteriormente una fase cuantitativa con una duración total de 4 años y medio. Durante la fase cualitativa se realizaron 44 entrevistas individuales en profundidad, 8 grupos focales y 10 observaciones etnográficas (hoteles, baños públicos (“teteras”), cines pornográficos, fiestas privadas, dark rooms y discotecas). Durante la fase cuantitativa del estudio se realizó el reclutamiento de 500 participantes que provinieron de la Ciudad Autónoma de Buenos Aires, así como del Gran Buenos Aires. El reclutamiento se comenzó con 16 participantes llamados semillas. Se realizó el diagnóstico de infección por HIV, hepatitis B y C (HBV y HCV), Treponema pallidum, Virus Papiloma Humano (HPV) y Chlamidias. La colaboración establecida entre los grupos de trabajo enfocados en áreas diversas posibilitó el abordaje conjunto de nuevas estrategias de investigación antes no exploradas en nuestro país. Los resultados más relevantes de esta investigación serán progresivamente publicados en sucesivos números de Actualizaciones en SIDA. PMID:25264397

Carballo-Diéguez, Alex; Ávila, María M; Balán, Iván C.; Marone, Rubén; Pando, María A.; Barreda, Victoria

2011-01-01

279

Perceived pros and cons of smoking and quitting in hard-core smokers: a focus group study  

PubMed Central

Background In the last decade, so-called hard-core smokers have received increasing interest in research literature. For smokers in general, the study of perceived costs and benefits (or ‘pros and cons’) of smoking and quitting is of particular importance in predicting motivation to quit and actual quitting attempts. Therefore, this study aims to gain insight into the perceived pros and cons of smoking and quitting in hard-core smokers. Methods We conducted 11 focus group interviews among current hard-core smokers (n = 32) and former hard-core smokers (n = 31) in the Netherlands. Subsequently, each participant listed his or her main pros and cons in a questionnaire. We used a structural procedure to analyse the data obtained from the group interviews and from the questionnaires. Results Using the qualitative data of both the questionnaires and the transcripts, the perceived pros and cons of smoking and smoking cessation were grouped into 6 main categories: Finance, Health, Intrapersonal Processes, Social Environment, Physical Environment and Food and Weight. Conclusions Although the perceived pros and cons of smoking in hard-core smokers largely mirror the perceived pros and cons of quitting, there are some major differences with respect to weight, social integration, health of children and stress reduction, that should be taken into account in clinical settings and when developing interventions. Based on these findings we propose the ‘Distorted Mirror Hypothesis’. PMID:24548463

2014-01-01

280

Changes to perceptions of the pros and cons of genetic susceptibility testing after APOE genotyping for Alzheimer disease risk  

PubMed Central

Purpose Perceptions about the pros and cons of genetic susceptibility testing are among the best predictors of test utilization. How actual testing changes such perceptions has yet to be examined. Methods In a clinical trial, first-degree relatives of patients with Alzheimer disease received genetic risk assessments for Alzheimer disease including APOE disclosure. Participants rated 11 possible benefits associated with genetic testing (pros) and 10 risks or limitations (cons) before genetic risk disclosure and again 12 months afterward. Results Pros were rated higher than cons at baseline (3.53 vs. 1.83, P < 0.001) and at 12 months after risk disclosure (3.33 vs. 1.88, P < 0.001). Ratings of pros decreased during the 12-month period (3.33 vs. 3.53, P < 0.001). Ratings of cons did not change (1.88 vs. 1.83, P = 0.199) except for a three-item discrimination subscale which increased (2.07 vs. 1.92, P = 0.012). Among specific pros and cons, three items related to prevention and treatment changed the most. Conclusion The process of APOE genetic risk assessment for Alzheimer disease sensitizes some to its limitations and the risks of discrimination; however, 1-year after disclosure, test recipients still consider the pros to strongly outweigh the cons. PMID:21270636

Christensen, Kurt D.; Roberts, J. Scott; Uhlmann, Wendy R.; Green, Robert C.

2011-01-01

281

Teatro Nacional Popular: Un teatro popular o la popularización del teatro (Entrevista con Alonso Alegría).  

E-print Network

va a ser hacia que se constituya en lo mejor del medio; pero a partir del medio, como una culminación del medio. El mismo concepto que un seleccionado nacional de fútbol, las estrellas de los diferentes equipos se reúnen para hacer un equipazo... pensar en un elenco como una culminación. Siguiendo con la metáfora futbolística, no había veinte, había cuatro equipos de fútbol; resultaba que no había ni siquiera cuatro, que eran los mismos once juga dores que rotaban de equipo en equipo y se...

Podesta A., Bruno

1973-10-01

282

[Severe acute asthma: isoflurane administration via AnaConDa™, is it safe?].  

PubMed

Standard treatments against severe acute asthma can be insufficient and need salvation treatments, such as isoflurane delivery. These treatments have not been much assessed and could lead to unrecognized side-effects. We report the case of a young man who suffered from intracranial hypertension associated with severe hypercapnia during the delivery of isoflurane via the system AnaConDa™ or Anaesthetic Conserving Device™ (ACD) (Sedama Medical). The rising of PaCO(2) appears to be linked to an ACD-dependent increase in the dead space. PMID:21146349

Chaillan, M; Badin, J; Kerforne, T; Voultoury, J; Pinsard, M

2011-01-01

283

'El teatro es un camino de autoconocimiento': Entrevista con Liuba Cid, directora teatral cubana  

E-print Network

Medeamaterial. Lo representamos en Madrid y en gira por provincias. He estado también en México, realizando una labor intensa por la zona de Quintana Roo, Yucatán con una obra infantil preciosa que en Cuba fue el mejor espectáculo en su género en 1988, de un... Universidad para hacer un intercambio de programas de estudios, de metodologías, pues a mí me atrae mucho la pedagogía y de hecho en cuanto me licencié, empecé a dar clases. Todos los planes de estudio de nuestra Universidad se intentaron traspasar a la...

Bravo-Elizondo, Pedro

1994-10-01

284

T cells produce TRF in response to Con A and factors in T cell hybridoma supernatants.  

PubMed

In recent experiments, a soluble factor (TRF) that mediates the differentiation of anti-immunoglobulin (Ig)-activated B cells to Ig-secreting cells has been identified. TRF works in concert with a growth factor, probably IL 2, in the induction of activated B cells. In previous studies, TRF was identified in culture supernatants of activated T cells and accessory cells, and thus the cellular source (T cell or accessory cell) of the factor was not determined. In the present studies, we succeeded in inducing the production of TRF by T cell populations from which accessory cells had been vigorously depleted. Lymph node cells were depleted of accessory cells by nylon wool adherence and anti-Ia and complement treatment; these cells were activated with Con A and a T cell hybridoma supernatant that contains IL 2. Supernatants from these activated T cell cultures supported the differentiation of anti-Ig-activated B cells to Ig secreting cells. These results show that T cells produce the differentiation factor, and further that they do so in response to ligand (Con A) plus a T cell-derived factor. PMID:6798126

Raulet, D H; Hünig, T; Parker, D C

1982-02-01

285

Uso de Sustancias en Mujeres con Desventaja Social: Riesgo para el Contagio de VIH/SIDA  

PubMed Central

Antecedentes La caracterización epidemiológica en Chile apunta a feminización, pauperización y heterosexualización de la epidemia del VIH, lo que implica un mayor riesgo para las mujeres en desventaja social. Si a esto se suma la utilización de sustancias, la vulnerabilidad de este grupo frente al VIH/SIDA aumenta. Objetivo Describir el uso de sustancias en mujeres con desventaja social e identificar factores de riesgo de contagio de VIH, asociados a este consumo. Material y Método 52 mujeres fueron entrevistadas como parte del proyecto “Testeando una intervención en prevención de VIH/SIDA en mujeres chilenas” GRANT # RO1 TW 006977. Se describen variables sociodemográficas y de consumo de sustancias a través de estadísticas descriptivas y se analiza la relación entre variables a través de pruebas de correlación. Resultados Los resultados indican un perfil sociodemográfico que sitúa a las mujeres en situación de vulnerabilidad frente al contagio de VIH/SIDA, con alto índice de uso de sustancias que acentúa el riesgo. Conclusiones Los hallazgos apuntan a la necesidad de considerar intervenciones que se enfoquen en la prevención de VIH en mujeres, abordando los riesgos asociados al consumo de sustancias. PMID:21197380

Cianelli, R.; Ferrer, L; Bernales, M.; Miner, S.; Irarrázabal, L.; Molina, Y.

2009-01-01

286

Actitudes Éticas de los estudiantes y egresados en carrera de medicina con metodologías activas  

PubMed Central

El presente estudio tiene por objeto desarrollar un diagnostico de la inserción integrada de la ética en la carrera de medicina brasileña con una metodología de aprendizaje basada en problemas y describir las percepciones de actitudes éticas de los estudiantes y egresados. El diseño metodológico es un estudio de caso, descriptivo y documental, con abordaje cualitativo y cuantitativo. La muestra de esta investigación ha sido constituida por 120 estudiantes y 40 egresados de dos promociones del Curso de Medicina de la ESCS. Este proyecto fue aprobado por el Comité de Ética en Investigación - SES/DF. Los estudiantes y egresados de la ESCS demostraron un buen manejo en el abordaje de los conflictos éticos y respeto a los pacientes. Sin embargo, el análisis de sensibilidad ética mostró una fragilidad en las percepciones y aptitudes inapropiadas de los estudiantes de la carrera de medicina, identificada básicamente en los años iniciales, que necesitan más discusiones sistematizadas sobre los aspectos éticos y bioéticos integrados a las actividades prácticas para estimular y fortalecer la reflexión ética de los estudiantes. PMID:20981242

Novaes, Maria Rita Carvalho Garbi; Novaes, Luiz Carlos Garcez; Guilhem, Dirce; Stepke, Fernando Lolas; Silveira, Carla Cristina Costa; Komatsu, Ricardo Shoiti; Trindade, Eliane Mendonça Vilar; Guiotti, Murilo Galvão

2010-01-01

287

Feeding of grey squirrels (Sciurus carolinensis) with the contraceptive agent DiazaCon™: effect on cholesterol, hematology, and blood chemistry.  

PubMed

Grey squirrels (Sciurus carolinensis) are an invasive species in Britain and Italy. They have replaced native red squirrels (Sciurus vulgaris) throughout most of Britain, and cause damage to trees. Currently, lethal control is used to manage grey squirrel populations in Britain, but nonlethal methods might be more acceptable to the public. One such method is contraception with 20,25-diazacholesterol dihydrochloride (DiazaCon™). DiazaCon™ inhibits the conversion of desmosterol to cholesterol, resulting in increasing desmosterol concentrations and decreasing cholesterol concentrations. Because cholesterol is needed for the synthesis of steroid reproductive hormones, such as progesterone and testosterone, inhibition of cholesterol synthesis indirectly inhibits reproduction. Desmosterol is used as a marker of efficacy in laboratory studies with species that do not reproduce readily in captivity. Grey squirrels were gavaged with a DiazaCon™ solution for 2 days, and then fed DiazaCon™-coated peanuts for an additional 8 days at target doses of 50 and 100 mg DiazaCon™ per kg body weight. There was a significant difference in cholesterol concentrations in the treatment groups compared to the control group. Cholesterol was reduced by ? 40% for 2 months in both treatment groups. There were no differences among groups with respect to blood chemistry and hematology parameters, and mean values are reported. The mean overall dose of DiazaCon™ received was 29.0 ± 1.6 and 55.3 ± 4.3 mg/kg in the low (50 mg/kg) and high dose (100 mg/kg) groups, respectively. DiazaCon™ might provide an effective, acceptable alternative to lethal control. PMID:22182332

Yoder, Christi A; Mayle, Brenda A; Furcolow, Carol A; Cowan, David P; Fagerstone, Kathleen A

2011-12-01

288

A comparison between LCM virus-specific secondary cytotoxic T lymphocytes generated by Con A and by the homologous antigen.  

PubMed Central

An investigation was made of the properties of cytotoxic T cells induced by Con A and exposure to LCM virus-infected cells. As a basis for such studies, the optimal conditions for in vitro Con A stimulation of in vivo LCM virus-primed C3H mouse splenocytes were determined. The most potent cytotoxicity was obtained when responder cells were cultured in the presence of Con A in a concentration of 2 micrograms/ml for 3 days, but strong cytotoxicity was also measured on days 2 and 4. When stimulation was performed by the homologous antigen maximal response was seen on day 4 although marked cytotoxicity was also noted on day 3. Effector cells produced by the two different procedures showed equally high degrees of cytotoxicity against LCM virus-infected target cells, whereas they did not appear cytotoxic against non-infected targets. If LCM virus-immune mice were treated intravenously with 280 micrograms of Con A per animal, moderate cytotoxicity was demonstrable in splenocytes from these mice 1, 2 and 3 days after treatment. The in vitro generation of secondary cytotoxicity by Con A as well as by the homologous antigen was found to be totally dependent on DNA synthesis. The reactivated cells were investigated for in vivo anti-viral effect by measuring their ability to protect intracerebrally LCM virus-infected mice from a fatal outcome of this infection. LCM virus-primed splenocytes stimulated by the homologous antigen caused complete protection, while Con A-reactivated cells did not protect at all. Secondary cytotoxic cells stimulated by Con A and by LCM virus showed fairly similar in vitro characteristics, but fundamentally different in vivo qualities. PMID:315920

Marker, O; Andersen, G T

1979-01-01

289

Comparison of phenotypic methods in predicting methicillin resistance in coagulase-negative Staphylococcus (CoNS) from animals.  

PubMed

Phenotypic detection of methicillin resistance in coagulase-negative Staphylococcus (CoNS) of animal origin has been challenging due to the heterogeneous expression of mecA. To compare different phenotypic methods in predicting the mecA presence in CoNS, a total of 87 CoNS isolates from agricultural animals were analyzed in this study by agar dilution, disk diffusion, and broth microdilution. mecA was present in 81 CoNS isolates. Broth microdilution demonstrated the highest sensitivity of 100% in predicting the mecA presence, followed by 72.8% by agar dilution and 70.4% by disk diffusion. The results indicate that broth microdilution may be more suitable for predicting the presence of mecA in CoNS from animals than the other two methods, although staphylococcal species may also be a factor affecting the sensitivities of the methods as the top three staphylococcal species in this study were Staphylococcus lentus, Staphylococcus sciuri, and Staphylococcus xylosus (a total of 75 of 87). PMID:20538309

Zhang, Yifan; Wang, Xiaogang; LeJeune, Jeffrey T; Zervos, Marcus; Bhargava, Kanika

2011-02-01

290

Involvement of ?-protocadherin in colorectal carcinogenesis: a promise for clinico-pathological evaluation.  

PubMed

Cell-cell adhesion is a fundamental activity to allow the maintenance of epithelial integrity, and defects impairing this process promote the formation of tumors such as colorectal cancer (CRC). In this regard, a crucial role is played by adhesion molecules, named cadherins, which exert their function through the inhibition of the ?-catenin signaling proliferation pathway, constitutively activated in CRC. A number of reports, published over the last decade, have highlighted the existence of a novel cadherin family member, called ?-protocadherin, to underline the hybrid nature of its extra-cellular region, including both cadherin-like and mucin-like domains. Is has been shown that this protein plays an important role in inter-cellular adhesion processes, inhibits ?-catenin activity in normal colorectal mucosa, undergoes a down-regulated expression in CRC and is up-regulated upon treatment with chemoprevention agents against this tumor. PMID:23904255

Losi, Lorena; Grande, Alexis

2014-01-01

291

Hereditary spastic paraplegia: clinico-pathologic features and emerging molecular mechanisms.  

PubMed

Hereditary spastic paraplegia (HSP) is a syndrome designation describing inherited disorders in which lower extremity weakness and spasticity are the predominant symptoms. There are more than 50 genetic types of HSP. HSP affects individuals of diverse ethnic groups with prevalence estimates ranging from 1.2 to 9.6 per 100,000. Symptoms may begin at any age. Gait impairment that begins after childhood usually worsens very slowly over many years. Gait impairment that begins in infancy and early childhood may not worsen significantly. Postmortem studies consistently identify degeneration of corticospinal tract axons (maximal in the thoracic spinal cord) and degeneration of fasciculus gracilis fibers (maximal in the cervico-medullary region). HSP syndromes thus appear to involve motor-sensory axon degeneration affecting predominantly (but not exclusively) the distal ends of long central nervous system (CNS) axons. In general, proteins encoded by HSP genes have diverse functions including (1) axon transport (e.g. SPG30/KIF1A, SPG10/KIF5A and possibly SPG4/Spastin); (2) endoplasmic reticulum morphology (e.g. SPG3A/Atlastin, SPG4/Spastin, SPG12/reticulon 2, and SPG31/REEP1, all of which interact); (3) mitochondrial function (e.g. SPG13/chaperonin 60/heat-shock protein 60, SPG7/paraplegin; and mitochondrial ATP6); (4) myelin formation (e.g. SPG2/Proteolipid protein and SPG42/Connexin 47); (5) protein folding and ER-stress response (SPG6/NIPA1, SPG8/K1AA0196 (Strumpellin), SGP17/BSCL2 (Seipin), "mutilating sensory neuropathy with spastic paraplegia" owing to CcT5 mutation and presumably SPG18/ERLIN2); (6) corticospinal tract and other neurodevelopment (e.g. SPG1/L1 cell adhesion molecule and SPG22/thyroid transporter MCT8); (7) fatty acid and phospholipid metabolism (e.g. SPG28/DDHD1, SPG35/FA2H, SPG39/NTE, SPG54/DDHD2, and SPG56/CYP2U1); and (8) endosome membrane trafficking and vesicle formation (e.g. SPG47/AP4B1, SPG48/KIAA0415, SPG50/AP4M1, SPG51/AP4E, SPG52/AP4S1, and VSPG53/VPS37A). The availability of animal models (including bovine, murine, zebrafish, Drosophila, and C. elegans) for many types of HSP permits exploration of disease mechanisms and potential treatments. This review highlights emerging concepts of this large group of clinically similar disorders. PMID:23897027

Fink, John K

2013-09-01

292

Epithelial toll-like receptor 9 signaling in colorectal inflammation and cancer: Clinico-pathogenic aspects  

PubMed Central

Toll-like receptors (TLRs) recognize specific motifs which are frequently present in bacteria, fungi, prokaryotes and viruses. Amongst TLRs, TLR9 can be activated by such bacterial or viral DNA fragments, immunoglobulin-DNA complexes or synthetic oligonucleotides, which all contain unmethylated cytosine-guanine nucleotide sequences (CpGs). Emerging data indicate that TLR9 signaling has a role in, and may influence, colorectal carcinogenesis and colonic inflammation. CpGs are classified into three groups according to their influence on both the antigen-specific humoral- and cellular immunity, and the production of type 1 interferons and proinflammatory cytokines. TLR9 activation via CpGs may serve as a new therapeutic target for several cancerous and various inflammatory conditions. Due to its probable anti-cancer effects, the application possibilities of TLR9-signaling modulation may be extremely diverse even in colorectal tumors. In this review we aimed to summarize the current knowledge about TLR-signaling in the pathogenesis and therapy of inflammatory bowel diseases and colorectal cancer. Due to the species-specific differences in TLR9 expression, however, one must be careful in translating the animal model data into the human system, because of the differences between CpG-oligodeoxynucleotide-responsive cells. TLR9 agonist DNA-based immunomodulatory sequences could also represent a promising therapeutic alternative in systemic inflammatory conditions and chronic colonic inflammations as their side effects are not significant. PMID:23864774

F?ri, István; Sipos, Ferenc; Germann, Tiana M; Kalmár, Alexandra; Tulassay, Zsolt; Molnár, Béla; M?zes, Györgyi

2013-01-01

293

Clinico-radiological profile and risk factors in patients with anthracosis  

PubMed Central

Background: Anthracosis is the black pigmentation of the mucosal lining of the tracheo-bronchial tree. The significance of this finding is not known and often ignored. The aim of the present study is to find the association of anthracosis with demographic variables, biomass fuel and occupational exposure, respiratory diseases, radiological pattern and functional morbidity. Materials and Methods: Enrolment of the subjects for the study was done at SMS hospital, Jaipur. Patients with anthracosis evident on bronchoscopy were included as the cases. Patients without anthracosis on bronchoscopy, matched according to age, gender and smoking habits, were included in the control group. Subjects in both the arms completed a questionnaire and also underwent computed tomography (CT) of the chest and six minute walk test (6MWT). Results: Thirty cases and 53 controls were included in the study. The patients with anthracosis presented with symptoms ranging from cough (76.65%), hemoptysis (46.6%), fever (26.6%), dyspnea (90%) and malaise (73.3%). Biomass fuel exposure for the cases was 35.13 ± 55.86 hours in a year and for the controls was 28.15 ± 40.09 hours in a year (P > 0.05). Stone mining was significantly associated with anthracosis (P < 0.05). CT chest revealed fibrosis (43.3%), consolidation (33.3%), cavitation (16.6%) and mass (46.6%) in the cases. Sixty percent of cases and 15% of controls were diagnosed to have either old or active pulmonary tuberculosis (P < 0.05). Conclusions: Anthracosis is associated with pulmonary tuberculosis. Biomass exposure is not significantly associated with anthracosis. Post tubercular fibrosis is more common on CT chest of patients with anthracosis.

Singh, Virendra; Meena, Hardayal; Bairwa, Ramavatar; Singh, Sheetu; Sharma, Bharat Bhushan; Singh, Ajeet

2015-01-01

294

The many clinico-pathologic faces of actinic keratosis: an atlas.  

PubMed

Actinic keratoses (AKs) are intraepithelial neoplasms formed by atypical keratinocyte proliferation. Histopathologically, typical AKs are characterized by a slightly thickened epidermis, usually with irregular downward buds, orthokeratosis alternating with parakeratosis ('pink and blue') with loss of the underlying granular layer and a disarrangement of the epidermis with atypical keratinocytes at the basal layer. There are several histopathological variants of AK according to the different degrees of keratinocytic atypia, epidermal hyperplasia/atrophy, inflammation and pigmentation. Some authors consider AK an early in situ squamous cell carcinoma and propose a classification of AK based on the extent of atypical keratinocytes in the epidermis. PMID:25561208

Massone, Cesare; Cerroni, Lorenzo

2015-01-01

295

[Clinico-neurophysiological features of the course of the disease in patients with paroxysmal atrial fibrillation].  

PubMed

The subjects of the study were 32 patients with paroxysmal atrial fibrillation (AF) and 19 ':ealthy individuals using a clinical and neurophysiological method of toposelective mapping of electroencephalogram (EEG). EEG was done during the inter-attack, pre-attack, and post-attack periods, as well as during a paroxysm. During the inter-attack period, the patients had a lower beta-rhythm power vs. the healthy controls, while there were no significant differences between them in the power of alpha- and beta-activity. Before an attack, the patients had a significant increase in beta, alpha-, and theta-range power, reflecting the intensification of the activity of the metaencephalic reticular formation, thalamocortical, and hypothalamosepto-hyppocampal systems, respectively. During an AF paroxysm, the activity of the thalamocortical and reticular systems was lowered, while the activity of the hypothalamo-hyppocampal system further increased. After an attack, the activity of all the mentioned systems went down to the initial state of the "optimal" brain functioning after an excessive excitation. It is assumed that generalized one-way direction of EEG changes before an attack reflects tensed functioning of practically all activation systems, which increases the probability of a "breakdown" in a form of an AF paroxysm. The data of the study evidence a cyclic character of the disease and stresses an important role in AF pathogenesis played by disturbances associated with the functional condition of non-specific temporal-limbic and reticular brain structures, especially in patients without organic myocardial alterations. PMID:17882807

Nedostup, A V; Vasiukov, S S; Gordeev, S A; Fedorova, V I

2007-01-01

296

Clinico-immunologic Study on Immunotherapy with Mixed and Single Insect Allergens  

Microsoft Academic Search

Background  Immunotherapy (IT) is practiced mainly with mixed and single allergen vaccines. But studies are rare with mixed allergen preparations.\\u000a \\u000a \\u000a \\u000a Objective  The objective of this study is to study mix and single insect allergen IT in patients of allergic rhinitis and asthma.\\u000a \\u000a \\u000a \\u000a Methods  We performed a double-blind placebo-controlled trial of mix and single allergen IT for 1 year in 99 patients of asthma or

Deepsikha Srivastava; Bhanu P. Singh; Naveen Arora; Shailendra Nath Gaur

2009-01-01

297

Rice (Oryza sativa) allergy in rhinitis and asthma patients: a clinico-immunological study.  

PubMed

Sensitization to foods varies in different countries reflecting a possible interaction of genetic factors, cultural and dietary habits. Rice is a major food consumed world wide and needs evaluation for IgE mediated reactions. The present study was carried out to identify rice allergy in patients of rhinitis and asthma and identify the allergenic proteins in raw and cooked rice. Of 1200 patients screened using standard questionnaire, 165 presented with history of rice allergy. Of these, 20 (12.1%) patients demonstrated marked positive skin prick test (SPT) and 13 showed significantly raised specific IgE to rice compared to normal controls. Double blind placebo controlled food challenge (DBPCFC) confirmed rice allergy in 6/10 patients. Immunoblot with hypersensitive individual patients' sera showed 14-16, 33, 56 and 60 kDa proteins as major IgE-binding components in rice. Boiled rice retained four IgE reactive proteins of 16, 23, 33 and 53 kDa. In summary, IgE-mediated rice allergy affects 0.8% [(0.42-1.58) at 95% CI] of asthma and rhinitis cases. The subjects with severe SPT reactions (4 mm or above) and specific IgE, 6.9 ng/ml to rice demonstrated positive blinded food challenge with clinical symptoms. PMID:17336834

Kumar, Raj; Srivastava, Prakriti; Kumari, Dolly; Fakhr, Hena; Sridhara, S; Arora, Naveen; Gaur, S N; Singh, B P

2007-01-01

298

Rice ( Oryza sativa) allergy in rhinitis and asthma patients: A clinico-immunological study  

Microsoft Academic Search

Sensitization to foods varies in different countries reflecting a possible interaction of genetic factors, cultural and dietary habits. Rice is a major food consumed world wide and needs evaluation for IgE mediated reactions. The present study was carried out to identify rice allergy in patients of rhinitis and asthma and identify the allergenic proteins in raw and cooked rice. Of

Raj Kumar; Prakriti Srivastava; Dolly Kumari; Hena Fakhr; S. Sridhara; Naveen Arora; S. N. Gaur; B. P. Singh

2007-01-01

299

Polyomavirus nephropathy: a brief review with special emphasis on clinico-patholgical aspects.  

PubMed

(Full text is available at http://www.manu.edu.mk/prilozi). From 1995 Polyomavirus (PyV) nephropathy (PVN) has played an important role in solid organ transplant recipients. The disease is caused by a DNA virus, usually the BK variant, more rarely JC virus. In immune incompetent patients either latent endogenous virus is reactivated, or donated virus can multiply. The frequency of PVN nephropathy (previously 10% or higher) is declining. The disease follows a stepwise course: viruria, viraemia, nephropathy. Nephropathy usually manifests itself during the first year after transplantation. The disease remains clinically silent for long periods, later progressive loss of renal function and renal failure occur. A major risk factor is therapy with potent immune suppressive agents. Morphologically, viral replication produces nuclear inclusions and necrosis, predominantly in the urothelium and tubular epithelium. Inflammation (T and B lymphocytes, monocytes/macrophages and granulocytes) accompanies necrosis. Progression is marked by tubular atrophy, interstitial fibrosis and transplant loss. The virus can be detected by the electron microscope and, better, by immunohistology (preferentially mAb against SV40 Large T antigen). It is often hard to differentiate PVN from an interstitial cellular rejection reaction (Banff 1 A/B). As no effective drug treatment exists, the disease must be diagnosed as early as possible and immune suppression reduced. Screening for polyomavirus reactivation is best done stepwise: search for urinary "Decoy cells" (PyV infected cells), PCR for PyV in the blood and in the case of reduced renal function, renal biopsy. Compliance with a stringent screening algorithm allows early detection and adequate treatment and prevents organ loss. Key words: Polyomavirus nephropathy, Virology, Clinical presentation, Morphology, "Decoy cells", Differential diagnosis, Screening algorithm. PMID:23425866

Mihatsch, M J

2012-12-01

300

A Clinico-pathological study on the effect of vincristine on transmissible venereal tumour in dogs.  

PubMed

Transmissible venereal tumour (TVT) is a coitally transmitted neoplasm of dogs and is common among sexually active dogs, where sexual behaviour is not under control. Several treatment options are available for the treatment of the tumour, with chemotherapy being the most commonly employed. In this study, we investigated the clinical and cytological changes after weekly vincristine sulphate administration in 38 cases of naturally occurring TVT. Tumours totally regressed in 31 dogs after two to seven doses (mean 3.54 +/- 1.01) of vincristine. One dog died after the fifth dose of vincristine, and in six dogs, an additional treatment with doxorubicin was needed. Masses were still present in four dogs and the histopathological examination revealed small nodules of granulation tissue in two dogs, while viable tumour cells were identified in the remaining two cases. No recurrences were observed in a follow-up period of 7-49 months (mean 13.64 +/- 9.66); in one dog, granulation tissue was detected in the surgery site after 2 months. Treatment success could easily be followed by the cytological changes. In conclusion, vincristine was found to be effective chemotherapeutic agent. PMID:16109105

Nak, D; Nak, Y; Cangul, I T; Tuna, B

2005-09-01

301

Clinico-Mycological Study of Dermatophyte Toenail Onychomycosis in New Delhi, India  

PubMed Central

Introduction: There is a constant need to define the epidemiological and mycological characteristics of onychomycosis (OM) for optimal management strategies. Objectives: To define the epidemiological and mycological characteristics of patients with dermatophyte toenail OM in a tertiary care hospital. Materials and Methods: Hundred consecutive patients of KOH and culture-positive dermatophyte toenail OM were subjected to detailed history, clinical examination and investigations. Results: Maximum number of patients (40%) belonged to 31-45 years age group and there was a male preponderance (M:F = 6.7:1). The mean duration of disease was 54 months. Thirty-three patients had fingernail involvement in addition to the toenail OM and 37% had co-existent cutaneous dermatophyte infection. Discoloration was the most common symptom (98%). Ninety-four (94%) patients had distal lateral subungual onychomycosis (DSLO) while two had superficial onychomycosis (SO) and only one had proximal superficial onychomycosis (PSO). Trichophyton interdigitale was the most common etiological agent (61%) followed by Trichophyton rubrum and Trichophyton verrucosum. Conclusions: Toenail OM is more common in males. DSLO was the most common clinical variant and T. interdigitale the most common etiological fungus responsible for toenail OM in our region. The importance of early diagnosis and treatment is highlighted as long-standing toenail OM predisposes to fingernail onychomycosis and recurrent tinea pedis. PMID:25814703

Yadav, Pravesh; Singal, Archana; Pandhi, Deepika; Das, Shukla

2015-01-01

302

Intraductal papillary mucinous neoplasm of the pancreas (IPMN): clinico-pathological correlations and surgical indications  

Microsoft Academic Search

BACKGROUND: Intraductal papillary mucinous neoplasms (IPMNs) are increasingly recognized entities, whose management remains sometimes controversial, due to the high rate of benign lesions and on the other side to the good survival after resection of malignant ones. METHODS: Retrospective analysis of a prospectively collected Western series of IPMN. RESULTS: Forty cases of IPMN were analysed (1992-2007). Most patients were symptomatic

Gian Luca Baiocchi; Nazario Portolani; Guido Missale; Carla Baronchelli; Federico Gheza; Massimiliano Cantù; Luigi Grazioli; Stefano M Giulini

2010-01-01

303

Oncoplastic breast surgery: initial experience at the Centro Clinico de Estereotaxia—CECLINES, Caracas, Venezuela  

PubMed Central

Background Breast-conserving surgery (BCS) may sometimes lead to deformities in the remaining breast. Oncoplastic surgery (OPS) aims to improve our aesthetic results even in the case of major volume resections. The purpose of this study is to provide an objective evaluation of our initial experience with OPS, mainly based on the levels of satisfaction reported by both patients and surgeons. Patients and Methods This prospective study was performed at CECLINES in Caracas, Venezuela, between January 2011 and October 2012. It involved 107 consecutive patients in two groups: 52 patients with level II OPS versus 55 patients with ‘standard’ BCS (SBCS). We evaluated the level of satisfaction and cosmetic outcome at 6 and 12 months post-operation using a score from 1 (bad) to 5 (excellent). The cosmetic score was recorded during the follow-up by the surgeon, by phone calls, and photographs were reviewed by a panel of four observers. Results The participation rate in the cosmetic outcome/level of satisfaction evaluation was 100% at 6 months and 96.2% at 12 months. The average tumour size was 23 mm [standard deviation (SD): 13.5] for the OPS group versus 17.6 mm (SD: 8.3) for the SBCS group (p = 0.017). The average weight for the surgical specimen was 101 g (range: 30–512 g) in the OPS group versus 60.4 g (range: 20–135 g) in the SBCS group (p = 0.004). The OPS techniques most performed were round block 40.3% (21/52), inverted T mammoplasty 26.8% (14/52) and vertical scar mammoplasty 15.3% (8/52). Of all the patients, 51.9% (27/52) had symmetrisation procedures performed distributed according to the period of the study: 77.2% (17/22) in 2011, 56.6% (17/30) in 2012, and 18.1% (6/33) in 2013. The rate of complications was 5.7% (3/52) in the OPS group and 0% for the SBCS group (p < 0.005). The average cosmetic score at 6 months by patients in the OPS group was 4.4; patient satisfaction scores of 4 (good) and 5 (excellent) were 88.4%. In the SBCS group at 6 months, the mean score reported by patients was 4.2, with scores 4–5 being 83.4% (p = 0.644). The cosmetic score by surgeons in the OPS group at 6 months was 4.5; the surgeon satisfaction scores of 4–5 were 94.2%. In the SBCS group, the surgeons’ mean score at 6 months was 4.1, with 84.5% of scores being 4 or 5 (p < 0.005). The final cosmetic score by patients in the OPS group at 12 months was 4.5; patient satisfaction scores of 4–5 were 90.4%. In the SBCS group, the final mean score at 12 months by patients was 4.2, with 77.5% of scores being 4 or 5 (p < 0.005). The final cosmetic score by surgeons in the OPS group at 12 months was 4.5; surgeon satisfaction scores of 4–5 were 92.3%. In the SBCS group, the surgeons’ final mean score at 12 months was 4.1, with 84.5% of scores being 4 or 5 (p < 0.005). Conclusions OPS provides good satisfaction rates. An SBCS when an OPS is not indicated mostly results in good satisfaction levels and cosmetic scores. Usually, the results remain stable after 6 months. The use of OPS allows the excision of bigger lesions and surgical specimens. Symmetrisation procedures are not always required. With the appropriate patient selection, the rate of complications is low for both OPS and SBCS. PMID:25374618

Acosta-Marin, V; Acosta-Freites, V; Contreras, A; Ravelo, R; Fuenmayor, G; Marin, C; Ramirez, A; Acosta-Marin, M; Perez-Fuentes, J; Longobardi, I; Esteves, H

2014-01-01

304

Clinico-radiological spectrum of bilateral temporal lobe hyperintensity: a retrospective review  

PubMed Central

Bilateral temporal lobe hyperintensity (BTH) is a commonly encountered MRI finding in a wide spectrum of clinical conditions and often poses a diagnostic challenge to the radiologist. The purpose of this paper is to elucidate several diseases that manifest as BTH on MRI, based on a retrospective review of cranial MRI of 65 cases seen in our institution between October 2007 and September 2010. We found BTH in different clinical scenarios that included infective diseases (herpes simplex virus, congenital cytomegalovirus infection), epileptic syndrome (mesial temporal sclerosis), neurodegenerative disorders (Alzheimer's disease, frontotemporal dementia, Type 1 myotonic dystrophy), neoplastic conditions (gliomatosis cerebri), metabolic disorders (mitochondrial encephalopathy, lactic acidosis and stroke-like episodes, Wilson's disease, hyperammonemia), dysmyelinating disease (megalencephalic leukoencephalopathy with subcortical cysts), and vascular (cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy) and paraneoplastic (limbic encephalitis) disorders. The conventional MRI findings with advanced MRI such as diffusion-weighted imaging, susceptibility-weighted imaging and MR spectroscopy along with laboratory results are potentially helpful in distinguishing the different clinical conditions and thus affect the early diagnosis and clinical outcome. PMID:22422381

Sureka, J; Jakkani, R K

2012-01-01

305

[Clinico-electrophysiologic relations in isolated complete atrioventricular block, congenital or idiopathic].  

PubMed

Congenital or idiopathic complete A-V block with no detectable heart disease may be complicated by near syncope, syncope or sudden death. The proposed predictive "risk factors" of these events have not proved sufficiently reliable so far. This study was undertaken in order to re-evaluate the correlation between symptoms and clinical and electrophysiological data with particular regard to the junctional recovery time in 10 patients (4 M; 6 F; mean age 24.4 +/- 9.6 at our first observation) with congenital or idiopathic complete A-V block. Patients were divided into 2 groups: group A (3 M; 3 F; mean age 27.8 +/- 10.6 at our first observation) with patients who complained of vertigo, near syncope or syncope before our study; group B (1 M; 3 F; mean age 19.2 +/- 4.1 at first observation) without cardiovascular symptoms before our study. In group A, Holter monitoring revealed periods of asystole longer than 3000 ms in 2, and ectopic ventricular arrhythmias mainly during effort in 2; ergometric stress test performed in 3 patients demonstrated ectopic ventricular arrhythmias in 2 (those who had ectopic ventricular arrhythmias at rest). In all patients the site of the block was suprahisian (demonstrated by electrophysiologic endocavitary study) with a normal H-V interval; mean junctional recovery time was 4.600 +/- 1.620 ms and corrected junctional recovery time was 3.088 +/- 1.500. Four patients had vertigo during the electrophysiologic endocavitary study. After Atropine 0.02 mg/Kg i.v. junctional recovery time and corrected junctional recovery time decreased respectively to 1052 +/- 238 and 166 +/- 38 ms (the measurement was made in 5 patients). In group B Holter monitoring revealed periods of asystole longer than 3000 ms in 1 case. All patients had ectopic ventricular arrhythmias, confirmed by the stress test. In this group too, the block was suprahisian (electrophysiologic endocavitary study) with normal H-V. Mean junctional recovery time was 5162 +/- 2408 ms; and corrected junctional recovery time 3687 +/- 2202. Two patients complained of dizziness during the electrophysiologic endocavitary study. After Atropine 0.02 mg/Kg i.v., junctional recovery time and corrected junctional recovery time decreased respectively to 1300 +/- 356 and 260 +/- 145 ms. Four group A and 1 group B patients received a permanent pacemaker and have remained asymptomatic since.(ABSTRACT TRUNCATED AT 400 WORDS) PMID:6376252

Guarnerio, M; Disertori, M; Vergara, G; Bettini, R; Inama, G; Durante, G; Furlanello, F

1984-04-01

306

Clinico-biochemical and therapeutic studies on notoedric mange in pet rabbits.  

PubMed

Two male and two female pet rabbits of about 1 year of age, naturally infested with Notoedres cuniculi were studied in the present investigation. Clinical examination revealed presence of crustaceous lesions on the head, ear pinnae, both the limbs and external genitalia. Microscopic examination of skin scrapings confirmed presence of Notoedres mange infestation. Biochemical parameters revealed altered values of total serum protein, albumin, globulin, and activities of aspartate amino transferase, alanine amino transferase and alkaline phosphatase respectively. The affected rabbits were treated with two injections of Ivermectin (400 ?g/kg, subcutaneously, at interval of 15 days) along with supportive therapy. This treatment showed appreciable improvement in clinical signs and restoration in biochemical parameters. PMID:25698873

Galdhar, C N; Khangal, P S; Pawar, M L; Rasal, T D; Digraskar, S U

2015-03-01

307

Diagnosis and clinico-radiological presentation in an aggressive maxillary brown tumour.  

PubMed

Brown's tumour is an uncommon focal giant cell lesion which arises as a result of the effect of increased parathyroid hormone on bone tissues in hyperparathyroidism. The mandible is the predominantly affected site in the maxillofacial area and a maxillary involvement is rare. The severity of the lesion, caused by a Brown's tumour, may lead to evident osteolysis and gross deformity in the maxillofacial region, which suggests the need for making an early diagnosis and giving prompt treatment. We are reporting a male patient who presented with a massive painful swelling in the right maxilla as the first manifestation of primary hyperparathyroidism, caused by a parathyroid adenoma. PMID:24995255

Pati, Abhishek Ranjan; Mubeen; Kr, Vijayalakshmi; Singh, Chandravir

2014-05-01

308

[Clinico-quatitative evaluation of the action of Ciba 34.647-Ba on spasticity].  

PubMed

Using the clinical quantification of the neurologic symptomatology the authors made observations and avaliated the action of Ciba 34.647-Ba, a GABA derivative, in 12 patients suffering from spasticity and motor incapacity due to spinal cord lesions. The results are reported emphasizing the effects of the drug on the main components of spasticity (hypertonus, hyperactivity of the deep reflexes, clonus and automatisms). Some theories explaining the mechanism of action of the drug are mentioned. References are made about doses, duration of action, tolerance and side-effects. PMID:588090

Roitman, I; Anghinah, A

1977-12-01

309

Demographic and Clinico-Epidemiological Features of Dengue Fever in Faisalabad, Pakistan  

PubMed Central

This cross-sectional study was carried out to explore the epidemiological and clinical features of dengue fever in Faisalabad, Pakistan during 2011 and 2012. During the study period, anti-dengue IgM positive cases were reported in the post-monsoon period during the months of August–December. Certain hotspots for the dengue infection were identified in the city that coincide with the clusters of densely populated urban regions of the city. Out of total 299 IgM positive patients (male 218 and female 81); there were 239 dengue fever (DF) and 60 dengue hemorrhagic fever (DHF) patients. There was decrease in the median age of dengue patients from 31 years in 2011 to 21.5 years in 2012 (p<0.001). Abdominal pain was seen in 35% DHF patients followed by nausea in 28.3%, epistaxis in 25% and rash in 20% patients (p<0.05). Patients reported to be suffering from high-grade fever for an average of 8.83 days in DHF as compared to 5.82 days in DF before being hospitalized. Co-morbidities were found to be risk factor for the development of DHF in dengue patients. Clinical and laboratory features of dengue cases studied could be used for the early identification of patients at risk of severe dengue fever. PMID:24595236

Raza, Faiz Ahmed; Rehman, Shafiq ur; Khalid, Ruqyya; Ahmad, Jameel; Ashraf, Sajjad; Iqbal, Mazhar; Hasnain, Shahida

2014-01-01

310

An integrated clinico-metabolomic model improves prediction of death in sepsis.  

PubMed

Sepsis is a common cause of death, but outcomes in individual patients are difficult to predict. Elucidating the molecular processes that differ between sepsis patients who survive and those who die may permit more appropriate treatments to be deployed. We examined the clinical features and the plasma metabolome and proteome of patients with and without community-acquired sepsis, upon their arrival at hospital emergency departments and 24 hours later. The metabolomes and proteomes of patients at hospital admittance who would ultimately die differed markedly from those of patients who would survive. The different profiles of proteins and metabolites clustered into the following groups: fatty acid transport and ?-oxidation, gluconeogenesis, and the citric acid cycle. They differed consistently among several sets of patients, and diverged more as death approached. In contrast, the metabolomes and proteomes of surviving patients with mild sepsis did not differ from survivors with severe sepsis or septic shock. An algorithm derived from clinical features together with measurements of five metabolites predicted patient survival. This algorithm may help to guide the treatment of individual patients with sepsis. PMID:23884467

Langley, Raymond J; Tsalik, Ephraim L; van Velkinburgh, Jennifer C; Glickman, Seth W; Rice, Brandon J; Wang, Chunping; Chen, Bo; Carin, Lawrence; Suarez, Arturo; Mohney, Robert P; Freeman, Debra H; Wang, Mu; You, Jinsam; Wulff, Jacob; Thompson, J Will; Moseley, M Arthur; Reisinger, Stephanie; Edmonds, Brian T; Grinnell, Brian; Nelson, David R; Dinwiddie, Darrell L; Miller, Neil A; Saunders, Carol J; Soden, Sarah S; Rogers, Angela J; Gazourian, Lee; Fredenburgh, Laura E; Massaro, Anthony F; Baron, Rebecca M; Choi, Augustine M K; Corey, G Ralph; Ginsburg, Geoffrey S; Cairns, Charles B; Otero, Ronny M; Fowler, Vance G; Rivers, Emanuel P; Woods, Christopher W; Kingsmore, Stephen F

2013-07-24

311

Endophthalmitis patients seen in a tertiary eye care centre in Odisha: A clinico-microbiological analysis  

PubMed Central

Background & objectives: Geographical variations are known to influence different aspects of endophthalmitis. We report the epidemiological, clinical and microbiological profile of patients with infectious endophthalmitis presented to a tertiary eye care centre in Odisha, India, and compare the results with published reports from other parts of India. Methods: Retrospective review of medical records of 107 patients, seen between December 2006 and January 2009 was done. All patients had undergone parsplana vitrectomy with intraocular antibiotics and the management was based on microbiological analysis of the vitreous fluid. Results: Forty six (43.0%) patients had post-operative (PO), 43 had post-traumatic (PT) and 18 (16.8%) had endogenous (EG) endophthalmitis. Males were predominant in all three types of endophthalmitis. Significantly younger individuals constituted PT group. While culture established microbial diagnosis in 45 patients (42%), direct microscopy was positive in 38 patients (35.5%). Fungal aetiology was found in 13 patients (PO-7, PT-4, EG-2) and bacteria accounted for 32. Similar to studies from north, central and south India, fungi and Gram-negative bacteria accounted for a large number of PO endophthalmitis cases. Two PT patients had polymicrobial infection. All Gram-positive bacteria were susceptible to vancomycin. Susceptibility to ceftazidime was variable among the Gram-negative bacteria. Best corrected visual acuity (BCVA) at presentation was less than 20/200 in majority (93%) of the patients. While the treatment outcome was variable in fungal and sterile endophthalmitis, the BCVA was either unchanged or improved in 100 per cent of bacterial endophthalmitis patients. Interpretation & conclusions: The spectrum of infection and outcome of infectious endophthalmitis in Odisha was similar to other parts of the country. Fungi and bacteria were involved in all three types of endophthalmitis. Empirical use of standard intravitreal therapy is recommended while emphasizing on vitreous biopsy for culture and sensitivity whenever possible. PMID:24604043

Sharma, Savitri; Padhi, Tapas R.; Basu, Soumyava; Kar, Sarita; Roy, Arvind; Das, Taraprasad

2014-01-01

312

Otomycosis--a clinico-mycological study and efficacy of mercurochrome in its treatment.  

PubMed

A total of 110 patients of symptomatic otomycosis was investigated, prospectively. Aural swabs were collected on 1st, 7th and 14th day and examined by direct microscopy and culture for fungi. Of these, 80 patients found to be having pure fungal infection, were taken up for mycological and therapeutic study. Fungi belonging to genus Aspergillus were isolated in 76 (95.0%) patients of which Aspergillus niger was the commonest isolate in 46 (57.5%), followed by A. flavus in 27 (33.7%), A. fumigatus in 3 (3.7%), Candida species in 3 (3.7%) and Mucor in 1 (1.2%). The patients were of all age groups but majority were between 21 and 30 years and the male-female ratio was equal. Of the total of 40 male patients, twenty-one were Sikhs using turban. Before developing the symptoms, forty five patients used oil, mixture of oil and garlic juice, antibiotics, steroids, antiseptics or wax solvent as ear drops. Only two patients were diabetic. No patient had fungal infection elsewhere in the body. The patients were called for regular follow-up for three weeks. In forty cases mercurochrome was applied as the antifungal agent after cleaning the external auditory canal, in twenty-three clotrimazole and in rest of the seventeen patients miconazole was used. On 7th day, only 11 (13.7%) patients grew different fungi in culture. They became symptom-free on 14th day and no fungal material could be seen on otoscopy, direct microscopy or culture. Mercurochrome was found to be most effective in these patients. PMID:9008878

Chander, J; Maini, S; Subrahmanyan, S; Handa, A

1996-01-01

313

Clinico-pathological correlates of incidentally revealed thyroid swelling in Bihar, India  

PubMed Central

Background: Global prevalence of thyroid cancer has been on the rise in recent decades. Objectives: To study the clinical presentations to reach an agreement for diagnosis and optimal management of incidentally revealed thyroid swellings for early diagnosis. Materials and Methods: A prospective study was carried out on 178 cases of incidentally detected thyroid swelling attending a tertiary care teaching institute of Kishanganj Bihar. All the cases were subjected to a thorough clinical examination followed by evidence-based interventions. Fine needle aspiration cytology was done in all the cases preoperatively as out-patients basis and histopathologically confirmed postoperatively. Results: The highest incidence of thyroid swelling (75.84%) was found in the age group of 20-40 years; a female preponderance was noted in the ratio 4:1. The duration of swelling ranged from six months to three years. Difficulty in swallowing and breathing was complained by 23 (12.9%) and 18 (10.1%) of the patients respectively. Typically the swellings were located in the right lobe. Commonly the subjects in our study were in euthyroid state (90%) and were with firm swellings (66.7%). Follicular and anaplastic carcinoma was important postoperative cytological findings. Majority of surgical intervention was hemithyroidectomy (55.06%). Conclusion: Incidentally revealed thyroid swelling was quite high in eastern India for which we need a consensus line of intervention. PMID:22368398

Sengupta, Arup; Pal, Ranabir; Kar, Sumit; Zaman, Forhad Akhtar; Basu, Mausumi; Pal, Shrayan

2012-01-01

314

Clinico-Radiological Diagnosis of Isolated Congenital Esophageal Stenosis in a Preterm Neonate  

PubMed Central

A 2-day-old preterm female neonate weighing 1.6?kg and having excessive frothing from mouth was investigated for suspected esophageal atresia and tracheoesophageal fistula. X-ray findings of an unusually low-ending upper pouch (up to T8 level) and the absence of gas in abdomen lead to suspicion of an unusual variety of esophageal atresia. Hence unlike the usual management of pure esophageal atresia, in terms of esophagostomy and gastrostomy in neonatal period, right thoracotomy was performed allowing successful primary anastomosis. A high index of suspicion on the basis of radiological picture led to early diagnosis of a rare anomaly like congenital esophageal stenosis and successful management of this low birth weight baby.

Sham, Minakshi

2013-01-01

315

Peripheral Desmoplastic Ameloblastoma in Adolescent Age: Clinico-Pathological and Immunohistochemical Analisys of a Case  

PubMed Central

The Extraosseous or Peripheral Ameloblastoma (PA) is a rare and benign odontogenic tumour, representing 1% to 5% of all ameloblastomas. It is usually localized in the soft oral tissues, without deep bone involvement. Its biological behaviour is specific, and several authors define PA as a non-infiltrating hamartomatous lesion. Indeed, recurrences rarely occur and progression in malignant tumors appears to be rare. The PA originates from the tooth-forming apparatus and it consists of proliferating odontogenic epithelium, exhibiting the same histological cell types and patterns of the intraosseous counterpart or infiltrating ameloblastoma. The peripheral desmoplastic ameloblastoma (PDA) can be classified as a newly recognized and very rare histological variant. To our knowledge, only a few cases of adult patients affected by PDA have been published. The aim of this paper is to report a case of PDA affecting an adolescent patient. The clinical-pathological and immunohistological features are discussed in order to improve knowledge regarding a correct diagnosis and to differentiate PDA lesions from similar diseases. PMID:25317210

Oteri, Giacomo; Lentini, Maria; Pisano, Michele; Cicciù, Marco

2014-01-01

316

Evaluation of clinico-epidemiological and histopathological features of pityriasis rosea  

PubMed Central

Introduction Pityriasis rosea is a sudden-onset and self limiting disease with specific skin rash. The exact etiology is still not clear. Aim To determine epidemiological, etiological, clinical and histopathological features in pityriasis rosea (PR). Material and methods Fifty two patients (older than 18 years) with PR were included in this study. Patients were examined for epidemiological and etiological features. Biopsy specimens obtained from secondary eruptions were histopathologically evaluated with hematoxylin-eosine and immunohistochemically evaluated with CD3 and CD20 monoclonal antibodies. Results Age range of patients was 18–53, mean age was 29.3 ±9.5 and women-to-men ratio was 1.08/1. Thirty-nine (75%) patients had a history of wearing new clothes, 27 (51.9%) patients had a history of recent respiratory tract infection, 15 (28.8%) patients had a history of recent gastrointestinal infection. Eczematous changes were detected in biopsy materials by histopathological evaluation, and cellular infiltrate was positively stained with pan T-cell marker CD3 and negatively stained with B lymphocyte marker CD20 in all biopsy materials in immunohistochemical examination. Conclusions In our study, frequency of pre-disease infection and prodromal symptoms history were determined to be higher than the results of similar studies in the literature. These higher results suggest that PR may be delayed-type hypersensitivity to an infectious factor. However, positive staining of all biopsy materials with pan T lymphocyte marker CD3 supports the association with cellular immunity. We believe that more extensive studies are needed on this issue. PMID:25254006

Özyürek, Gaye Devrim; Çenesizo?lu, Erol

2014-01-01

317

[Hyperechogenicity of the renal medulla in children: clinico-echographic correlations].  

PubMed

Increased renal medullary echogenicity by renal ultrasound associated with hypercalciuria and nephrocalcinosis is often present in childhood. 17 children, 9 boys and 8 girls, aged from 8 months to 10 years were classified into three groups based on ultrasound findings according to Patriquin and Robitaille: type A faint hyperechogenic rim around the sides and tip of the medullary pyramid; type B more intense echogenic rim of the pyramids; type C intense echoes throughout the pyramid. Clinic-echographic correlations showed a pattern C in 4 children with distal renal tubular acidosis and in an infant treated with furosemide; pattern B in 3 patients having different types of tubulopathy associated with hypercalciuria; pattern A in 6 children with congenital tubulopathy and in 3 children treated with vitamin D. Abdominal X-rays detected medullary calcinosis in 2 (11.7%) of total 17 patients. Ultrasonography appears to be an important tool in early diagnosis of renal medullary nephrocalcinosis. PMID:9162341

Sorino, P; Giordano, M; Puteo, F; Palumbo, F; Rossiello, P; Caringella, D A

1996-12-01

318

Clinico-epidemiological study of Schistosomiasis mansoni in Waja-Timuga, District of Alamata, northern Ethiopia  

PubMed Central

Background Intestinal schistosomiasis, caused by digenetic trematodes of the genus Schistosoma, is the most prevalent water related disease that causes considerable morbidity and mortality. Although prevalence of Schistosoma mansoni infection has been reported for the present study area, earlier studies have not estimated intensity of infections in relation to periportal fibrosis, which would have been crucial for epidemiological and clinical evaluations. Hence, a community based cross sectional study was conducted from December 2011 to March 2012 to assess prevalence of infection and schistosomal periportal fibrosis in Waja-Timuga, northern Ethiopia. Methods In a cross sectional study involving 371 randomly selected individuals, fresh stool samples were collected and processed by the Kato-Katz method and examined microscopically. Ultrasonography was used to determine status of schistosomal periportal fibrosis and to detect hepatomegaly and/or splenomegaly. Serum was collected for assay of hepatic activity. Statistical analysis was performed using STATA 11 statistical soft ware. P-value <0.05 was reported as statistically significant. Results The prevalence of S.mansoni infection was 73.9%, while the prevalence of schistosomal periportal fibrosis was 12.3% and mean intensity of infection was 234 eggs per gram of stool. Peak prevalence and intensity of S.mansoni infection was documented in the age range of 10–20 years. Among the study individuals, hepatomegaly was recorded in 3.7% and splenomegaly was recorded in 7.4% of the study individuals. Similarly, among the study individuals who had definite periportal fibrosis, 5.9% had elevated liver enzyme levels. Conclusion The high prevalence of Schistosoma mansoni infection and schistosomal periportal fibrosis observed in the study area calls for a periodic deworming program to reduce disease, morbidity and transmission. Preventive chemotherapy complemented with other control measures is highly required for sustainable control of schistosomiasis in the study area. PMID:24690404

2014-01-01

319

Autoimmune hepatitis, one disease with many faces: Etiopathogenetic, clinico-laboratory and histological characteristics  

PubMed Central

Autoimmune hepatitis (AIH) is an unresolving progressive liver disease of unknown etiology characterized by hypergammaglobulinemia, autoantibodies detection and interface hepatitis. Due to the absence of specific diagnostic markers and the large heterogeneity of its clinical, laboratory and histological features, AIH diagnosis may be potentially difficult. Therefore, in this in-depth review we summarize the substantial progress on etiopathogenesis, clinical, serological and histological phenotypes of AIH. AIH has a global distribution affecting any age, both sexes and all ethnic groups. Clinical manifestations vary from asymptomatic to severe or rarely fulminant hepatitis. Hypergammaglobulinemia with selective elevation of IgG is found in most cases. Autoimmune attack is perpetuated, possibly via molecular mimicry, and favored by the impaired control of T-regulatory cells. Histology (interface hepatitis, emperipolesis and hepatic rosette formation) and autoantibodies detection although not pathognomonic, are still the hallmark for a timely diagnosis. AIH remains a major diagnostic challenge. AIH should be considered in every case in the absence of viral, metabolic, genetic and toxic etiology of chronic or acute hepatitis. Laboratory personnel, hepato-pathologists and clinicians need to become more familiar with disease expressions and the interpretation of liver histology and autoimmune serology to derive maximum benefit for the patient. PMID:25574080

Gatselis, Nikolaos K; Zachou, Kalliopi; Koukoulis, George K; Dalekos, George N

2015-01-01

320

Visual associative agnosia: a clinico-anatomical study of a single case.  

PubMed Central

A single case study of a patient with visual associative agnosia is described. The patient had well preserved language, spatial, visual, and perceptual abilities but nevertheless was impaired in recognising visually presented common objects. It is argued that his deficit cannot be accounted for in terms of a disconnection syndrome. Behavioural and anatomical (MRI scan) evidence for focal unilateral dysfunction is presented. It is concluded that the left hemisphere plays a crucial role in recognising the meaning of common objects. Images PMID:3794729

McCarthy, R A; Warrington, E K

1986-01-01

321

White matter in temporal lobe epilepsy: clinico-pathological correlates of water diffusion abnormalities  

PubMed Central

Using magnetic resonance imaging, it is possible to measure the behavior of diffusing water molecules, and the metrics derived can be used as indirect markers of tissue micro-architectural properties. Numerous reports have demonstrated that patients with temporal lobe epilepsy (TLE) have water diffusion abnormalities in several white matter structures located within and beyond the epileptogenic temporal lobe, showing that TLE is not a focal disorder, but rather a brain network disease. Differences in severity and spatial extent between patients with or without mesial temporal sclerosis (MTS), as well as differences related to hemispheric seizure onset, are suggestive of different pathophysiological mechanisms behind different forms of TLE, which in turn result in specific cognitive disabilities. The biological interpretation of diffusion abnormalities is based on a wealth of information from animal models of white matter damage, and is supported by recent reports that directly correlate diffusion metrics with histological characteristics of surgical specimens of TLE patients. Thus, there is now more evidence showing that the increased mean diffusivity (MD) and concomitant reductions of diffusion anisotropy that are frequently observed in several white matter bundles in TLE patients reflect reduced axonal density (increased extra-axonal space) due to smaller-caliber axons, and abnormalities in the myelin sheaths of the remaining axons. Whether these histological and diffusion features are a predisposing factor for epilepsy or secondary to seizures is still uncertain; some reports suggest the latter. This article summarizes recent findings in this field and provides a synopsis of the histological features seen most frequently in post-surgical specimens of TLE patients in an effort to aid the interpretation of white matter diffusion abnormalities.

Rodríguez-Cruces, Raúl

2015-01-01

322

Clinico-immunogenetic characteristics of multiple sclerosis with optic neuritis in children  

Microsoft Academic Search

The frequency of multiple sclerosis (MS) with clinical onset before 16 years of age in different regions of Russia fluctuates from 2 to 10% of all MS patients. One of the most frequent signs of MS manifestation and\\/or exacerbation at this age is optic neuritis (ON). Forty-seven children with MS were observed in Moscow. Diagnosis of MS in every case

ME Guseva; S Yu Boiko; MA Sudomoina; OV Bikova; OI Maslova

323

[Clinico-statistical study of inpatients and autopsied cases in our clinic].  

PubMed

The statistics of clinical observation at Department of Internal Medicine, Nippon Dental University at Niigata from July 1981 to December 1987 (duration 6.5 years) were as follows: Total number of inpatients: 1,238, Total number of death cases: 106. Findings include: 1) Ratio of male patients to female patients 1.34:1.00. Male deceased patients to female deceased patients 1.52:1.00. 2) Average patients number hospitalized per year was 200. The high percentaged of certain advanced aged groups was reflected by the recent demographic changes in the society in general.; in their 60's 46.0%, in their 70's 24.3%, in their 80's 6.7%. In these age groups, female number is tendency to increase the number of male. 3) The diseases of inpatients were mostly due to the digestive tract, which accounted for 60.4% of the total. Of this percentage, 65% was due to hepato-biliary diseases. 4) The death statistics of malignant tumor was 68.9%; Benign diseases being 31.1%. Male patients died from hepatocellar carcinoma, lung cancer, colon cancer and stomach cancer, in descending order. Females died from cancer of the biliary tract, stomach cancer and hepatocellular carcinoma, again, in descending order. 5) 71.7% of all deaths were caused by the digestive tract, in particular, hepatocellular carcinoma, cancer of the biliary tract, liver cirrhosis and primary biliary cirrhosis, all belonging primarily to the hepato-biliary disease group. 6) As a result of 58 autopsies performed for 106 death cases, 32 cases had complete autopsies and 26 cases had partial organ punctures. PMID:2761960

Shibasaki, K; Maeta, Y; Soga, K; Toshima, M; Aikawa, K; Itoh, T; Sakakibara, A; Katagiri, M; Kitano, Y; Tsuchikawa, K

1989-04-01

324

Pyloric gland adenoma: a clinico-pathological analysis of 90 cases  

Microsoft Academic Search

Background. Pyloric gland adenoma is a rarely described neoplasia of the gastric mucosa. Recent publications have shown that similar lesions are also found in the gallbladder, the main pancreatic duct, the duodenum and the cervix of the uterus. Apart from case reports, few clinical data are available on these patients. We therefore conducted a search of the archived material collected

R. Kushima; F. Borchard; M. Stolte

2003-01-01

325

Inherited metabolic disorders involving the eye: a clinico-biochemical perspective  

Microsoft Academic Search

The diagnosis of inborn errors of metabolism is challenging for most physicians. Improvements in medical technology and greater knowledge of the human genome are resulting in significant changes in the diagnosis, classification, and treatment of inherited metabolic disorders (IMDs). Many known inborn errors of metabolism will be recognised earlier or treated differently because of these changes. It is important that

M Rajappa; A Goyal; J Kaur

2010-01-01

326

Some clinico-immunological aspects in patients with ocular myasthenia gravis associated with inflammatory bowel disease.  

PubMed

The link between inflammatory bowel disease (IBD) and ocular myasthenia gravis (OMG) is thought to be related to the production of autoantibodies. The aim of this study was to determine the incidence of some antibodies in OMG patients with IBD. Sixty-four patients with IBD and neurological symptoms were examined neurologically and immunologically (41 men and 23 women, mean age 43-5.4 years); mean duration of IBD before the diagnosis of OMG was 7.5 years. The following immunological investigations were performed: anti-acetylcholine receptor antibodies (AChR Abs) (ELISA), anti-smooth muscle antibodies (ASMA) (indirect immunofluorescence), perinuclear anti-neutrophilic cytoplasmic antibodies (p-ANCA) (indirect immunofluorescence), carcinoembryonic antigen (CEA) (ELISA), Saccharomyces cerevisiae antibodies IgA and IgG (ASCA) (ELISA), peripheral lymphocyte counts, immature CD4, CD4/CD8 ratio. Five patients out of 64 with IBD presented OMG. The following antibodies were observed: anti-AChR in 4 OMG patients, ASMA in 4 OMG patients, p-ANCA in 4 OMG patients, CEA in 5 OMG patients, ASCA IgA and IgG in 3 OMG patients. Of 5 OMG patients 4 were positive for >3 antibodies. The peripheral lymphocytic counts were reduced in 5 OMG patients, a decline in CD8 cells and an increase in immature CD4 cells in 5 OMG patients, an increased CD4/CD8 ratio in 5 OMG patients were observed. The association of IBD with OMG was rare. Autoimmune dysregulation is the central defect in both MG and IBD. Further studies are required to define the nature of this association. PMID:19284089

Cojocaru, Inimioara Mihaela; Cojocaru, M; T?n?sescu, R; Burcin, Cecilia; Atanasiu, Adina Nicoleta; Mitu, Andreea Cristina; Iliescu, Iuliana; Dumitrescu, Laura

2008-01-01

327

Picking transplant glomerulopathy out of the CAN: evidence from a clinico-pathological evaluation  

PubMed Central

Background Since the term chronic allograft nephropathy (CAN) was removed from the Banff scheme in 2005, transplant glomerulopathy (TG) has been regarded as a clinicopathological entity that is one of the major causes of graft loss. To assess the distinction between CAN and TG, we performed a comprehensive evaluation comparing TG with traditional CAN. Methods We compared the clinicopathological features of 43 cases of TG with 43 matched cases of non-TG CAN (non-TG group) after renal transplantation. TG was diagnosed by light microscopy based on the double contours of the glomerular basement membranes, and the Banff 97 classification system was used to score TG severity (cg0-3). Results Compared to the control group, we found a significantly higher incidence of positivity for human leukocyte antigen class-I and II antibodies, a higher incidence of hepatitis C virus (HCV) infection, and poorer graft survival in TG patients. Clinically, TG was associated with a higher prevalence of proteinuria, hematuria, anaemia and hypoalbuminemia. Histologically, TG strongly correlated with antibody related microcirculatory injuries, including glomerulitis, peritubular capillaritis and peritubular capillary (PTC) C4d deposition. Interestingly, the TG patients showed a significantly higher incidence of IgA deposition than the control patients. C4d-positive TG was correlated with higher TG and PTC scores, and PTC C4d deposition was correlated with a more rapid progression to graft dysfunction. TG accompanied by HCV infection was associated with heavier proteinuria, higher TG and C4d scores, and poorer graft survival. Conclusions TG presents clinicopathological features that are distinct from non-TG cases and leads to poorer outcomes. PTC C4d deposition is related to a more rapid progression to graft loss, suggesting ongoing antibody reactivity. HCV-positive TG is a more severe sub-entity, that requires further investigation. PMID:23020166

2012-01-01

328

The role of the radiologist in surgical management: an audit of clinico-radiological conferences.  

PubMed

A prospective analysis of the radiological findings and final diagnoses of 342 patients discussed at joint surgical/radiological conferences over a seven-month period was undertaken in an attempt to define the role of the radiologist in the clinical management of surgical patients. Although the diagnosis had already been correctly made on clinical or radiological grounds in 38% (130/342) of patients presented at the X-ray conferences, careful review of the films resulted in an immediate firm diagnosis in a further 9% (31/342), or promoted further radiological investigations which were responsible for an eventual definitive diagnosis in 20% of the remainder (32/169). The input of the radiologist in selecting the most appropriate additional investigation was particularly valuable in the management of more complex clinical problems. PMID:8796212

Dennison, A R; Kerrigan, D D; Oakley, N; Paraskevopoulos, J A; Peck, R; Collins, M C; Johnson, A G

1996-08-01

329

Clinico-pathological Study of Space Occupying Lesions of Nasal Cavity, Paranasal Sinuses and Nasopharynx  

PubMed Central

Background: A variety of non-neoplastic and neoplastic lesions of nasal cavity, paranasal sinuses and nasopharynx are commonly encountered in clinical practice. The aim of this study was to study clinical and histopathological profile of space occupying lesions of nasal cavity, paranasal sinuses and nasopharynx in a tertiary care hospital of Rajasthan over the period of January 2013 to January 2014. Materials and Methods: This was a prospective study of 147 cases (male 100, female 47; age group ranging from less than 1 y to 76 y) of space occupying lesions of nasal cavity, paranasal sinuses and nasopharynx over the period of 12 months (from January 2013 to January 2014). All tissues after fixation in 10% buffered formalin, processed and then stained with Hematoxylin & Eosin to study various histopathological patterns. Results: These 147 cases were broadly categorized in two categories, one category as nasal and paranasal sinus masses and the other as nasopharyngeal masses with 91 and 56 cases, respectively. These lesions were common in second and third decades of life with male predominance. Among nasal and paranasal sinus masses, there were 67 (73.6%) non-neoplastic and 24 (26.4%) neoplastic lesions. Inflammatory polyps (89.5%) were the most common among the non-neoplastic masses; Inverted papilloma (45.46%) the most common among the benign neoplastic and squamous cell carcinoma (46.15%) was the commonest out of all malignant masses. Out of 56 nasopharyngeal masses, there were 53 (94.6%) non neoplastic and 3 (5.4%) neoplastic lesions. Majority of these i.e. 52 cases were of adenotonsillar hypertrophy. Conclusion: We concluded that complete clinical, radiological and histopathological correlation helps us to categorize these sinonasal lesions into various non-neoplastic and neoplastic types. But final histopathological examination provides a confirmatory diagnosis, although Immunohistochemistry is the final diagnostic method in few cases. PMID:25584226

Mathur, Kusum

2014-01-01

330

Hereditary spastic paraplegia: clinico-pathologic features and emerging molecular mechanisms  

PubMed Central

Hereditary spastic paraplegia (HSP) is a syndrome designation describing inherited disorders in which lower extremity weakness and spasticity are the predominant symptoms. There are more than 50 genetic types of HSP. HSP affects individuals diverse ethnic groups with prevalence estimates ranging from 1.2 to 9.6 per 100,000 [39, 70, 77, 154, 185]. Symptoms may begin at any age. Gait impairment that begins after childhood usually worsens very slowly over many years. Gait impairment that begins in infancy and early childhood may not worsen significantly. Post mortem studies consistently identify degeneration of corticospinal tract axons (maximal in the thoracic spinal cord) and degeneration of fasciculus gracilis fibers (maximal in the cervico-medullary region). HSP syndromes thus appear to involve motor-sensory axon degeneration affecting predominantly (but not exclusively) the distal ends of long central nervous system (CNS) axons. In general, proteins encoded by HSP genes have diverse functions including axon transport (e.g. SPG30/KIF1A, SPG10/KIF5A and possibly SPG4/Spastin); endoplasmic reticulum morphology (e.g. SPG3A/Atlastin, SPG4/Spastin, SPG12/reticulon 2, and SPG31/REEP1, all of which interact); mitochondrial function (e.g. SPG13/chaperonin 60/heat shock protein 60, SPG7/paraplegin; and mitochondrial ATP6; 4) myelin formation (e.g. SPG2/Proteolipid protein and SPG42/Connexin 47); 5) protein folding and ER-stress response (SPG6/NIPA1, SPG8/K1AA0196 (Strumpellin), SGP17/BSCL2 (Seipin) [113-115], “mutilating sensory neuropathy with spastic paraplegia” due to CcT5 mutation and presumably SPG18/ERLIN2); 6) corticospinal tract and other neurodevelopment (e.g. SPG1/L1 cell adhesion molecule and SPG22/thyroid transporter MCT8); 7) fatty acid and phospholipid metabolism (e.g. SPG28/DDHD1, SPG35/FA2H, SPG39/NTE, SPG54/DDHD2, and SPG56/CYP2U1); and 8) endosome membrane trafficking and vesicle formation (e.g. SPG47/AP4B1, SPG48/KIAA0415, SPG50/AP4M1, SPG51/AP4E, SPG52/AP4S1, and VSPG53/VPS37A). The availability of animal models (including bovine, murine, zebrafish, Drosophila, and C. elegans) for many types of HSP permits exploration of disease mechanisms and potential treatments. This review highlights emerging concepts of this large group of clinically similar disorders. For recent review of HSP including historical descriptions, differential diagnosis, and additional references see [78]. PMID:23897027

Fink, John K.

2014-01-01

331

LUSSAZIONE PALMARE ISOLATA DELL'ARTICOLAZIONE RADIO ULNARE DISTALE: PRESENTAZIONE DI UN CASO CLINICO  

Microsoft Academic Search

Isolated volar distal radio-ulnar joint dislocation: case report SUMMARY Palmar distal radio-ulnar joint (DRUJ) dislocation is a rare injury that may occur isolated from other injuries but, most frequently occurs in association with a distal radius fracture. In the literature, no more than 20 cases of pa- tients with isolated DRUJ dislocation were found. The diagnosis of this injury is

M. CALCAGNI; T. GIESEN; R. LUCHETTI; U. MARTORANA; G. PAJARDI

332

Patterns of levodopa response in Parkinson's disease: a clinico-pathological study  

Microsoft Academic Search

Patients with Parkinson's disease who develop disabling levodopa-induced motor fluctuations have a stronger therapeutic response than those who experience a more modest but stable response. A difference in the his- topathological lesion between the two groups might be responsible. Case records from 97 patients with patho- logically proven Parkinson's disease were reviewed to determine the pattern of levodopa response. Pathological

P. A. Kempster; D. R. Williams; M. Selikhova; J. Holton; T. Revesz; A. J. Lees

2007-01-01

333

[Non-tubercular and non-brucellar spondylodiscitis: preliminary clinico-microbiologic analysis of 37 cases].  

PubMed

Disk-space infection caused by organisms other than Mycobacterium tuberculosis or Brucella species seems to be an emerging disease due to an increase of the population at risk. However, few data are presently available from Italian institutions. In this article we report our "tot" month prospective experience on etiology and clinical presentation of disk-space infections in relation to their community (COM) or nosocomial (postoperative [POS] or non-postoperative [NPOS]) acquisition. Major results were: 1) a different microbial distribution among etiologies of COM, NPOS and POS infections; 2) more frequent distance infection as predisponing factor among NPOS infection than among COM and NPOS ones; 3) absence of fever and more frequent radicular extension of pain among POS infections. Due to the numerous potential microbial etiologies, culture of TC guided-disk aspirated material is of paramount importance for pathogen-targeted antimicrobial therapy. PMID:14974149

Bianco, Gianluca; Pompeo, Maria Elena; Mastroianni, Claudio; Trasimeni, Guido; Paris, Alberto; Coletta, Simona; Vullo, Vincenzo; Serra, Pietro; Venditti, Mario

2003-12-01

334

Correlation between CT Perfusion and Clinico-Pathological Features in Prostate Cancer: A Prospective Study  

PubMed Central

Background The aim of the study was to assess the correlation between computed tomography perfusion (PCT) parameters and PSA levels, Gleason score, and pTNM stage in patients with prostate cancer (PCa). Material/Methods One hundred twenty-five patients with localized PCa were prospectively enrolled in the study. All patients were diagnosed due to suspicious prostate findings and elevated PSA serum levels and underwent PCT followed by core biopsy and radical prostatectomy. Blood flow (BF), blood volume (BV), mean transit time (MTT), and permeability-surface (PS) area product were computed in the suspected PCa area and normal prostatic tissue. Core biopsy followed by prostatectomy was performed 2–4 weeks after PCT. Correlation between PCT findings and PSA levels, Gleason score, and pTNM stage were analyzed. Results The mean age of patients was 64 years. All patients had elevated PSA levels (mean value 6.2 ng/ml). Nineteen patients (15.9%) were at low risk of recurrence, 91 (76.5%) were at moderate risk, and 9 (7.6%) were at high risk according to National Comprehensive Cancer Network criteria. PCa was visible on PCT as focal peripheral CT enhancement in 119 out of 125 patients (sensitivity 95.2%). Significant correlations between BV, BF, and PS values and PSA level were found (p<0.05), as well as a trend for difference between BV, BF, and PS in poorly and moderately differentiated tumors (according to Gleason score) in comparison with highly differentiated PCa (p<0.08). The analysis also revealed a correlation between mean perfusion values and BV, MTT, PS, and pTNM cancer stage (p<0.04). Conclusions Our study suggests that in low- and intermediate- risk patients, PCT parameters correlate with PSA values, Gleason score, and pTNM stage and can be useful for initial tumor staging. PMID:25582437

?uczy?ska, El?bieta; Heinze-Paluchowska, Sylwia; Blecharz, Pawe?; Jereczek-Fossa, Barbara; Petralia, Giuseppe; Bellomi, Massimo; Stelmach, Andrzej

2015-01-01

335

[Clinico-electrophysiological study of behavior disorders in children with oligophrenia].  

PubMed

EEG correlation analysis was performed in 32 oligophrenic children aged 8 to 12 years at a debility stage with prominent behavioral changes. Compared to healthy age-matched persons, in patients spatial potential synchronization was decreased, interhemispheric correlations prevailed over the intrahemispheric ones, the interrelations within the left hemisphere reduced not only in projection zones but also in infraparietal ones. PMID:2728748

Shipitsina, L M; Ivanov, E S

1989-01-01

336

[Clinico-psychological study of deaf children and adolescents with residual organic syndromes and oligophrenia].  

PubMed

Standard methods were employed to study clinically and psychologically 70 deaf schoolchildren with psychic developmental defects. These techniques allowed assignment of the schoolchildren to different groups by mental and cognitive capacity. Comparative assessment of clinical and psychological findings contributed to differentiation of dysontogenetic variants: mental retardation, encephalopathic forms of borderline intellectual deficiency and oligophrenia. A specific pattern of cognitive functions in deaf children should be accounted for when making differential diagnosis of clinical forms of mental deficiency in congenital and early acquired deafness. PMID:3188765

Saraev, S Ia

1988-01-01

337

Clinico-pathological and biomolecular findings in Italian patients with multiple cutaneous neurofibromas  

PubMed Central

Background Neurofibroma occurs as isolated or multiple lesions frequently associated with neurofibromatosis type 1 (NF1), a common autosomal dominant disorder affecting 1 in 3500 individuals. It is caused by mutations in the NF1 gene, which comprises 60 exons and is located on chromosome 17q11.2. NF1 is a fully penetrant gene exhibiting a mutation rate some 10-fold higher compared with most other disease genes. As a consequence, a high number of cases (up to 50%) are sporadic. Mutation detection is complex due to the large size of the NF1 gene, the presence of pseudogenes and the great variety of lesions. Methods 110 patients with at least two neurofibroma lesions recorded in the files of the Pathology Department of the University of Modena during the period 1999-2010, were included in this study. Through interviews and examination of clinical charts, pedigrees were drawn for all patients who were affected by at least two neurofibromas. We attempted to delineate the clinical features of NF1 and the mutational spectrum in the cohort of 11 NF1 families identified. For each proband, the whole coding sequence and all splice sites were studied for mutations, either by the protein truncation test (PTT), or, more frequently, by denaturing high performance liquid chromatography (DHPLC). Two GIST tumors of NF1 patients were tested for somatic NF1 mutations. Results NF1 germline mutations were identified in 7 (68%) patients. A novel mutation, c.3457_3460delCTCA in exon 20, was detected in two unrelated patients and was associated with different clinical features. No NF1 somatic mutations were detected in the GIST tumors. A wide phenotypic and genotypic variability was registered, both in the spectrum of skin lesions and visceral neoplasms, even among members of the same family who had different clinical manifestations. A proclivity to multiple tumors arising in the same subject, and a higher tumor burden per family were the most relevant findings observed in patients affected with the NF1 mutation. Conclusions We report a novel NF1 mutation and we contribute data for the refinement of the NF1 genotype-phenotype spectrum. PMID:21838856

2011-01-01

338

Pattern Analysis and Decision Support for Cancer through Clinico-Genomic Profiles  

NASA Astrophysics Data System (ADS)

Advances in genome technology are playing a growing role in medicine and healthcare. With the development of new technologies and opportunities for large-scale analysis of the genome, genomic data have a clear impact on medicine. Cancer prognostics and therapeutics are among the first major test cases for genomic medicine, given that all types of cancer are related with genomic instability. In this paper we present a novel system for pattern analysis and decision support in cancer. The system integrates clinical data from electronic health records and genomic data. Pattern analysis and data mining methods are applied to these integrated data and the discovered knowledge is used for cancer decision support. Through this integration, conclusions can be drawn for early diagnosis, staging and cancer treatment.

Exarchos, Themis P.; Giannakeas, Nikolaos; Goletsis, Yorgos; Papaloukas, Costas; Fotiadis, Dimitrios I.

339

An integrated clinico-metabolomic model improves prediction of death in sepsis  

PubMed Central

Sepsis is a common cause of death, but outcomes in individual patients are difficult to predict. Elucidating the molecular processes that differ between sepsis patients who survive and those who die may permit more appropriate treatments to be deployed. We examined the clinical features, and the plasma metabolome and proteome of patients with and without community-acquired sepsis, upon their arrival at hospital emergency departments and 24 hours later. The metabolomes and proteomes of patients at hospital admittance who would die differed markedly from those who would survive. The different profiles of proteins and metabolites clustered into fatty acid transport and ?-oxidation, gluconeogenesis and the citric acid cycle. They differed consistently among several sets of patients, and diverged more as death approached. In contrast, the metabolomes and proteomes of surviving patients with mild sepsis did not differ from survivors with severe sepsis or septic shock. An algorithm derived from clinical features together with measurements of seven metabolites predicted patient survival. This algorithm may help to guide the treatment of individual patients with sepsis. PMID:23884467

Langley, Raymond J.; Tsalik, Ephraim L.; van Velkinburgh, Jennifer C.; Glickman, Seth W.; Rice, Brandon J.; Wang, Chunping; Chen, Bo; Carin, Lawrence; Suarez, Arturo; Mohney, Robert P.; Freeman, Debra H.; Wang, Mu; You, Jinsam; Wulff, Jacob; Thompson, J. Will; Moseley, M. Arthur; Reisinger, Stephanie; Edmonds, Brian T.; Grinnell, Brian; Nelson, David R.; Dinwiddie, Darrell L.; Miller, Neil A.; Saunders, Carol J.; Soden, Sarah S.; Rogers, Angela J.; Gazourian, Lee; Fredenburgh, Laura E.; Massaro, Anthony F.; Baron, Rebecca M.; Choi, Augustine M.K.; Corey, G. Ralph; Ginsburg, Geoffrey S.; Cairns, Charles B.; Otero, Ronny M.; Fowler, Vance G.; Rivers, Emanuel P.; Woods, Christopher W.; Kingsmore, Stephen F.

2014-01-01

340

Sacrococcygeal teratomas: clinico-pathological characteristics and isochromosome 12p status.  

PubMed

The biological behavior of teratomas is highly variable, and morphologic features alone are insufficient to predict their clinical course. Prognostic factors that influence behavior include the following: patient sex, age, anatomic site, coincident neoplasm, and cytogenetic abnormalities. Gonadal teratomas have been well-characterized; postpubertal testicular teratomas are commonly associated with isochromosome 12p (i12p) and considered to nearly always carry a potential for malignant behavior, whereas ovarian and prepubertal testicular teratomas are i12p negative and predominantly benign in behavior. For extragonadal sites, such as sacrum and coccyx, clinical characteristics and i12p status are yet to be adequately characterized. As part of this study, we identified 19 sacrococcygeal teratomas in our surgical pathology archives from 1990 to 2012. Clinical records and slides were reviewed to confirm the original diagnosis. Gains in chromosome 12p, including i12p status were assessed in representative paraffin sections by fluorescence in situ hybridization. Our cases included 16 mature sacrococcygeal teratomas (11 prepubertal and 5 postpubertal) and three immature saccrococygeal teratomas (all prepubertal). Among mature teratomas, the average tumor size was larger in adults compared with prepubertal patients. A higher number of adult cases were recurrences (80% vs 21%), but only pediatric recurrences were managed with postoperative chemotherapy. All examined tumors were negative for i12p. 100% survival was documented in our cohort with a median follow-up of 6 years. We present a large series of sacrococcygeal teratomas and the first series to examine postpubertal adults at this anatomic site. All tumors lacked chromosome 12p gains, including i12p. Both pre- and postpubertal sacrococcygeal teratomas had a favorable outcome regardless of age or sex. PMID:24051698

Gurda, Grzegorz T; VandenBussche, Christopher J; Yonescu, Raluca; Gonzalez-Roibon, Nilda; Ellis, Carla L; Batista, Denise A S; Netto, George J

2014-04-01

341

Pro-Con Debate: Etomidate or Ketamine for Rapid Sequence Intubation in Pediatric Patients  

PubMed Central

When caring for critically ill children, airway management remains a primary determinant of the eventual outcome. Airway control with endotracheal intubation is frequently necessary. Rapid sequence intubation (RSI) is generally used in emergency airway management to protect the airway from passive regurgitation of gastric contents. Along with a rapid acting neuromuscular blocking agent, sedation is an essential element of RSI. A significant safety concern regarding sedatives is the risk of hypotension and cardiovascular collapse, especially in critically ill patients or those with pre-existing comorbid conditions. Ketamine and etomidate, both of which provide effective sedation with limited effects on hemodynamic function, have become increasingly popular as induction agents for RSI. However, experience and clinical investigations have raised safety concerns associated with both etomidate and ketamine. Using a pro-con debate style, the following manuscript discusses the use of ketamine versus etomidate in RSI. PMID:23118665

Scherzer, Daniel; Leder, Mark; Tobias, Joseph D.

2012-01-01

342

Nest destruction elicits indiscriminate con- versus heterospecific brood parasitism in a captive bird.  

PubMed

Following nest destruction, the laying of physiologically committed eggs (eggs that are ovulated, yolked, and making their way through the oviduct) in the nests of other birds is considered a viable pathway for the evolution of obligate interspecific brood parasitism. While intraspecific brood parasitism in response to nest predation has been experimentally demonstrated, this pathway has yet to be evaluated in an interspecific context. We studied patterns of egg laying following experimental nest destruction in captive zebra finches, Taeniopygia guttata, a frequent intraspecific brood parasite. We found that zebra finches laid physiologically committed eggs indiscriminately between nests containing conspecific eggs and nests containing heterospecific eggs (of Bengalese finches, Lonchura striata vars. domestica), despite the con- and heterospecific eggs differing in both size and coloration. This is the first experimental evidence that nest destruction may provide a pathway for the evolution of interspecific brood parasitism in birds. PMID:25512846

Shaw, Rachael C; Feeney, William E; Hauber, Mark E

2014-12-01

343

Nest destruction elicits indiscriminate con- versus heterospecific brood parasitism in a captive bird  

PubMed Central

Following nest destruction, the laying of physiologically committed eggs (eggs that are ovulated, yolked, and making their way through the oviduct) in the nests of other birds is considered a viable pathway for the evolution of obligate interspecific brood parasitism. While intraspecific brood parasitism in response to nest predation has been experimentally demonstrated, this pathway has yet to be evaluated in an interspecific context. We studied patterns of egg laying following experimental nest destruction in captive zebra finches, Taeniopygia guttata, a frequent intraspecific brood parasite. We found that zebra finches laid physiologically committed eggs indiscriminately between nests containing conspecific eggs and nests containing heterospecific eggs (of Bengalese finches, Lonchura striata vars. domestica), despite the con- and heterospecific eggs differing in both size and coloration. This is the first experimental evidence that nest destruction may provide a pathway for the evolution of interspecific brood parasitism in birds. PMID:25512846

Shaw, Rachael C; Feeney, William E; Hauber, Mark E

2014-01-01

344

76 FR 54533 - Pipeline Safety: Issuance of Draft Decision on GexCon US, Inc. Petition for Approval of Flame...  

Federal Register 2010, 2011, 2012, 2013, 2014

This notice advises owners and operators of liquefied natural gas facilities and other interested parties that the Administrator has issued a Draft Decision on GexCon US, Inc.'s petition for approval of Flame Acceleration Simulator (FLACS). The Draft Decision is available for public inspection at Docket No. PHMSA-2011-0101 at http://...

2011-09-01

345

Global trade in dairy products involves complex and con-tentious issues. Viewed broadly from the perspective of  

E-print Network

products containing milk. Nonfat dry milk, cheese and whey products together make up about halfGlobal trade in dairy products involves complex and con- tentious issues. Viewed broadly from. International trade in dairy products is small relative to production and is highly concentrated. Among major

Radeloff, Volker C.

346

Connessione di R Nota. Se c R, con la frase intervallo di centro c intendiamo intervallo di centro c e  

E-print Network

1 Connessione di R Nota. Se c R, con la frase intervallo di centro c intendiamo intervallo di centro c e raggio un numero reale maggiore di 0. La seguente proposizione `e stata dimostrata a lezione ed `e analoga a [GDM, 6.3.1]. Essa dice che un insieme A `e aperto se e solo se per ogni c A esiste

Marconi, Umberto

347

iPathCons and iPathDB: an improved insect pathway construction tool and the database  

PubMed Central

Insects are one of the most successful animal groups on earth. Some insects, such as the silkworm and honeybee, are beneficial to humans, whereas others are notorious pests of crops. At present, the genomes of 38 insects have been sequenced and made publically available. In addition, the transcriptomes of dozens of insects have been sequenced. As gene data rapidly accumulate, constructing the pathway of molecular interactions becomes increasingly important for entomological research. Here, we developed an improved tool, iPathCons, for knowledge-based construction of pathways from the transcriptomes or the official gene sets of genomes. Considering the high evolution diversity in insects, iPathCons uses a voting system for Kyoto Encyclopedia of Genes and Genomes Orthology assignment. Both stand-alone software and a web server of iPathCons are provided. Using iPathCons, we constructed the pathways of molecular interactions of 52 insects, including 37 genome-sequenced and 15 transcriptome-sequenced ones. These pathways are available in the iPathDB, which provides searches, web server, data downloads, etc. This database will be highly useful for the insect research community. Database URL: http://ento.njau.edu.cn/ipath/ PMID:25388589

Zhang, Zan; Yin, Chuanlin; Liu, Ying; Jie, Wencai; Lei, Wenjie; Li, Fei

2014-01-01

348

A Model-based Approach to Reactive Self-Con guring Systems Brian C. Williams and P. Pandurang Nayak  

E-print Network

-based diagnosis, and by framing a model-based con guration manager as a proposi- tional feedback controller architecture for NASA's rst New Millennium spacecraft. Introduction and Desiderata NASA has put forth) to be launched in 1998. The nal pressure, low cost, is of an equal magnitude. To- gether this poses

Veloso, Manuela M.

349

1. Introduction In a uid con ned to a plane layer and heated from below, convection can  

E-print Network

1. Introduction In a uid con#12;ned to a plane layer and heated from below, convection can occur of convective behaviour loses stability to another. This paper is concerned with the analysis of the temporal behaviour of two-dimensional double convection: roll convection in the presence of a stabilizing solute

Rucklidge, Alastair

350

Genova Silicon Valley 10th Edition Incontro a Economia con Ettore Leale, 29 novembre , ore 17, aula Embriaco  

E-print Network

Genova Silicon Valley 10th Edition Incontro a Economia con Ettore Leale, 29 novembre , ore 17, aula Embriaco E' partito da Genova, nel 2005, il ponte tra Italia e Silicon Valley a beneficio degli studenti social network www.siliconvalleystudytour.com, hanno partecipato alle 9 edizioni del Silicon Valley Study

Robbiano, Lorenzo

351

Premio Internazionale Vittorio Foa Citt di Formia in collaborazione con l'IPAB SS. Annunziata e la Fondazione ALZAIA ONLUS  

E-print Network

1 Premio Internazionale Vittorio Foa ­ Città di Formia in collaborazione con l'IPAB SS. Annunziata Regolamento del "Premio Internazionale Vittorio Foa - Città di Formia", pubblicato sul sito www.premiovittoriofoa.it, viene bandita la 1° edizione del premio intitolato alla memoria di Vittorio Foa. Il Premio è istituito

Guidoni, Leonardo

352

TECHNOLOGY EVALUATION REPORT: INTERNATIONAL WASTE TECHNOLOGIES/GEO-CON IN SITU STABILIZATION/SOLIDIFICATION - VOLUME III - UPDATE REPORT  

EPA Science Inventory

The long-term performance tests provide information on the first follow-up sampling and analysis on the SITE program demonstration of the International Waste Technologies additive, and the Geo-Con deep soil mixing equipment. he samples containing PCBs, were collected one year aft...

353

TECHNOLOGY EVALUATION REPORT: INTERNATIONAL WASTE TECHNOLOGIES/GEO-CON IN SITU STABILIZATION/SOLIDIFICATION - VOLUME IV - UPDATE REPORT  

EPA Science Inventory

The long-term performance tests provide information on the first follow-up sampling and analysis on the SITE program demonstration of the International Waste Technologies additive, and the Geo-Con deep soil mixing equipment. he samples containing PCBs, were collected one year aft...

354

Cause of injury: Contact with tentacles which con-tain stinging cells that inject venom into the skin.  

E-print Network

JELLYFISH Cause of injury: Contact with tentacles which con- tain stinging cells that inject venom. Prevention: Take care when swimming in areas known to have jellyfish. Tentacles of some species may trail a great distance from the body. Rubber diving suits give protec- tion. Avoid touching jellyfish washed up

355

Comparación de resultados del método de clasificación de órbitas por análisis de frecuencias con el método de exponentes de Lyapunov  

Microsoft Academic Search

Hemos realizado extensas comparaciones del método de análisis de frecuencias con el de exponentes de Lyapunov. El primero resulta claramente superior por las siguientes razones: 1) permite distinguir distintos tipos de órbitas y no sólo si son regulares o caóticas 2) es mucho más veloz requiriendo mucho menos tiempo de cómputo. La concordancia de resultados es, en general, buena y

D. D. Carpintero; J. C. Muzzio; F. C. Wachlin

1998-01-01

356

SITE PROGRAM APPLICATIONS ANALYSIS REPORT, INTERNATIONAL WASTE TECHNOLOGIES/GEO CON IN-SITU STABILIZATION/SOLIDIFICATION  

EPA Science Inventory

An evaluation was performed of the International Waste Technologies (IWT) HWT-20 additive and the Geo-Con, Inc. deep-soil-mixing equipment for an in situ stabilization/solidification process and its applicability as an on-site treatment method for waste site cleanup. emonstration...

357

DISTRIBUZIONE DELLE FORZE DI CONTATTO NELL'ACCOPPIAMENTO CON INTERFERENZA TRA UNA MOLLA ELICOIDALE ED UN PERNO CILINDRICO  

Microsoft Academic Search

Sommario Il lavoro è incentrato sulla distribuzione delle forze di contatto scambiate nell'accoppiamento con interferenza tra una molla elicoidale ed un perno cilindrico. Tale accoppiamento è utilizzato per realizzare dispositivi di fissaggio efficaci, reversibili, rapidi ed economici. Lo studio è articolato in tre passi. Nel primo passo si sviluppa un modello analitico di previsione della distribuzione delle forze di contatto

I. Spinella; E. Dragonia Castagnetti

358

ScholarShip programS conSideration given to the following min Sat awardS given  

E-print Network

ScholarShip programS conSideration given to the following min Sat (freShmen) and/or gpa number of awardS given & amount renewable? SCHOLARSHIPS AWARDED THROUGH THE UNIVERSITY HONORS PROGRAM University Honors Program Scholarship Incoming freshmen and transfer students who are intellectually curious

Hutcheon, James M.

359

Factor de independencia a la distracción en el trastorno por déficit de atención con hiperactividad: un modelo abreviado  

Microsoft Academic Search

El factor independencia a la distracción (FID) del WISC-R presenta frecuentemente resultados infe- riores al factor organización perceptiva (FOP) y comprensión verbal (FCV) en casos de Trastorno por Déficit de Atención con Hiperactividad (TDAH). La formulación FID< (FCV + FOP)\\/2 tiene buena sensibilidad para TDAH. El objetivo principal de este estudio ha sido reducir el número de pruebas ne- cesarias

José Antonio; López Villalobos

360

Conocimientos, concepciones erróneas y lagunas de los maestros sobre el trastorno por déficit de atención con hiperactividad  

Microsoft Academic Search

Este estudio se diseñó para analizar los conocimientos, concepciones erróneas y lagunas sobre el Tras- torno por Déficit de Atención con Hiperactividad (TDAH) de 193 maestros, como una replicación de un estudio realizado por Sciutto, Terjesen y Bender en el año 2000. Los maestros cumplimentaron el Knowledge of Attention Deficit Hyperactivity Disorder (KADDS) en su versión española, adaptada por los

Sonia Jarque Fernández; Raúl Tárraga Mínguez; Ana Miranda Casas

2007-01-01

361

iPathCons and iPathDB: an improved insect pathway construction tool and the database.  

PubMed

Insects are one of the most successful animal groups on earth. Some insects, such as the silkworm and honeybee, are beneficial to humans, whereas others are notorious pests of crops. At present, the genomes of 38 insects have been sequenced and made publically available. In addition, the transcriptomes of dozens of insects have been sequenced. As gene data rapidly accumulate, constructing the pathway of molecular interactions becomes increasingly important for entomological research. Here, we developed an improved tool, iPathCons, for knowledge-based construction of pathways from the transcriptomes or the official gene sets of genomes. Considering the high evolution diversity in insects, iPathCons uses a voting system for Kyoto Encyclopedia of Genes and Genomes Orthology assignment. Both stand-alone software and a web server of iPathCons are provided. Using iPathCons, we constructed the pathways of molecular interactions of 52 insects, including 37 genome-sequenced and 15 transcriptome-sequenced ones. These pathways are available in the iPathDB, which provides searches, web server, data downloads, etc. This database will be highly useful for the insect research community. Database URL: http://ento.njau.edu.cn/ipath/ PMID:25388589

Zhang, Zan; Yin, Chuanlin; Liu, Ying; Jie, Wencai; Lei, Wenjie; Li, Fei

2014-01-01

362

0^T^^^tf^*nl~~~~ ORNL/CON-154 Nonlinear Analysis of Stirling  

E-print Network

. #12;ORNL/CON-154 Engineering Technology Division NONLINEAR ANALYSIS OF STIRLING ENGINE THERMODYNAMICS encouragement. #12;NONLINEAR ANALYSIS OF STIRLING ENGINE THERMODYNAMICS R. D. Banduric N. C. J. Chen ABSTRACT Numerical solutions to a simplified mathematical formula- tion for Stirling engine thermodynamics, including

Oak Ridge National Laboratory

363

Treatment of plutonium contaminated soil/sediment from the Mound site using the ACT*DE*CON{sup SM} process  

SciTech Connect

The removal and/or treatment of contaminated soil is a major problem facing the US DOE. The EG&G Mound Applied Technologies site in Miamisburg, Ohio, has an estimated 1.5 million cubic feet of soils from past disposal and waste burial practices awaiting remediation from plutonium contamination. This amount includes sediment from the Miami-Erie Canal that was contaminated in 1969 following a pipe- rupture accident. Conventional soil washing techniques that use particle separation would generate too large a waste volume to be economically feasible. Therefore, innovative technologies are needed for the cleanup. The ACT*DE*CON process was developed by SELENTEC for washing soils to selectively dissolve and remove heavy metals and radionuclides. ACT*DE*CON chemically dissolves and removes heavy metals and radionuclides from soils and sediments into an aqueous medium. The ACT*DE*CON process uses oxidative carbonate/chelant chemistry to dissolve the contaminant from the sediment and hold the contaminant in solution. The objective of recent work was to document the proves conditions necessary to achieve the Mound-site and regulatory-cleanup goals using the ACT*DE*CON technology.

Negri, M.C. [Argonne National Lab., IL (United States); Swift, N.A. [SELENTEC, Atlanta, GA (United States); North, J.P. [Rust Remedial Service, Inc., Anderson, SC (United States)

1996-10-01

364

South Florida Sun-Sentinel.com Playing sports year-round has its pros and cons for high  

E-print Network

South Florida Sun-Sentinel.com Playing sports year-round has its pros and cons for high school't mind playing basketball 11 out of 12 months a year. The Westminster Academy senior plays for his school for a college to get a look rather than try and force the colleges to come to me during the school year," Ross

Belogay, Eugene A.

365

Controlando el Deslave de la Irrigacion de Aspersión, la Erosión, y la Perdida del Fósforo con Paja y Poliacrilamido  

Microsoft Academic Search

RESUMEN. Controlar la erosión por deslave y erosión es importante para mantener la productividad del suelo y reducir el destrucción fuera del sitio debido al enriquecimiento de sedimentos y nutrientes. Comparamos los efectos combinados del residuo superficial de PAM en el deslave, perdidas de suelo de suelo irrigado con aspersores en el laboratorio. Hipotizamos que el residuo superficial pudiese mejorar

D. L. Bjorneberg; J. K. Aase; D. T. Westermann

2000-01-01

366

Pros and cons of liver transplantation in human immunodeficiency virus infected recipients  

PubMed Central

Before the introduction of combined highly active antiretroviral therapy, a positive human immunodeficiency virus (HIV) serological status represented an absolute contraindication for solid organ transplant (SOT). The advent of highly effective combined antiretroviral therapy in 1996 largely contributed to the increased demand for SOT in HIV-positive individuals due to increased patients’ life expectancy associated with the increasing prevalence of end-stage liver disease (ESLD). Nowadays, liver failure represents a frequent cause of mortality in the HIV-infected population mainly due to coinfection with hepatitis viruses sharing the same way of transmission. Thus, liver transplantation (LT) represents a reasonable approach in HIV patients with stable infection and ESLD. Available data presently supports with good evidence the practice of LT in the HIV-positive population. Thus, the issue is no longer “whether it is correct to transplant HIV-infected patients”, but “who are the patients who can be safely transplanted” and “when is the best time to perform LT”. Indeed, the benefits of LT in HIV-infected patients, especially in terms of mid- and long-term patient and graft survivals, are strictly related to the patients’ selection and to the correct timing for transplantation, especially when hepatitis C virus coinfection is present. Aim of this article is to review the pros and cons of LT in the cohort of HIV infected recipients. PMID:24833865

Baccarani, Umberto; Righi, Elda; Adani, Gian Luigi; Lorenzin, Dario; Pasqualucci, Alberto; Bassetti, Matteo; Risaliti, Andrea

2014-01-01

367

Indirect Ultraviolet Photodesorption from CO:N2 Binary Ices — an Efficient Grain-gas Process  

NASA Astrophysics Data System (ADS)

Ultraviolet (UV) ice photodesorption is an important non-thermal desorption pathway in many interstellar environments that has been invoked to explain observations of cold molecules in disks, clouds, and cloud cores. Systematic laboratory studies of the photodesorption rates, between 7 and 14 eV, from CO:N2 binary ices, have been performed at the DESIRS vacuum UV beamline of the synchrotron facility SOLEIL. The photodesorption spectral analysis demonstrates that the photodesorption process is indirect, i.e., the desorption is induced by a photon absorption in sub-surface molecular layers, while only surface molecules are actually desorbing. The photodesorption spectra of CO and N2 in binary ices therefore depend on the absorption spectra of the dominant species in the sub-surface ice layer, which implies that the photodesorption efficiency and energy dependence are dramatically different for mixed and layered ices compared with pure ices. In particular, a thin (1-2 ML) N2 ice layer on top of CO will effectively quench CO photodesorption, while enhancing N2 photodesorption by a factor of a few (compared with the pure ices) when the ice is exposed to a typical dark cloud UV field, which may help to explain the different distributions of CO and N2H+ in molecular cloud cores. This indirect photodesorption mechanism may also explain observations of small amounts of complex organics in cold interstellar environments.

Bertin, Mathieu; Fayolle, Edith C.; Romanzin, Claire; Poderoso, Hugo A. M.; Michaut, Xavier; Philippe, Laurent; Jeseck, Pascal; Öberg, Karin I.; Linnartz, Harold; Fillion, Jean-Hugues

2013-12-01

368

Pros and cons of liver transplantation in human immunodeficiency virus infected recipients.  

PubMed

Before the introduction of combined highly active antiretroviral therapy, a positive human immunodeficiency virus (HIV) serological status represented an absolute contraindication for solid organ transplant (SOT). The advent of highly effective combined antiretroviral therapy in 1996 largely contributed to the increased demand for SOT in HIV-positive individuals due to increased patients' life expectancy associated with the increasing prevalence of end-stage liver disease (ESLD). Nowadays, liver failure represents a frequent cause of mortality in the HIV-infected population mainly due to coinfection with hepatitis viruses sharing the same way of transmission. Thus, liver transplantation (LT) represents a reasonable approach in HIV patients with stable infection and ESLD. Available data presently supports with good evidence the practice of LT in the HIV-positive population. Thus, the issue is no longer "whether it is correct to transplant HIV-infected patients", but "who are the patients who can be safely transplanted" and "when is the best time to perform LT". Indeed, the benefits of LT in HIV-infected patients, especially in terms of mid- and long-term patient and graft survivals, are strictly related to the patients' selection and to the correct timing for transplantation, especially when hepatitis C virus coinfection is present. Aim of this article is to review the pros and cons of LT in the cohort of HIV infected recipients. PMID:24833865

Baccarani, Umberto; Righi, Elda; Adani, Gian Luigi; Lorenzin, Dario; Pasqualucci, Alberto; Bassetti, Matteo; Risaliti, Andrea

2014-05-14

369

Long-Acting Injectable Antipsychotics for First-Episode Schizophrenia: The Pros and Cons  

PubMed Central

Clinical and psychosocial deterioration associated with schizophrenia occurs within the first few years following the onset of the illness. Therefore, to improve the long-term prognosis, it is important to provide schizophrenia patients with intensive treatment following their first episode. Relapse is highly associated with partial medication adherence or nonadherence in patients with first-episode schizophrenia. Recent studies suggest that long-acting injectable (LAI) antipsychotics compared with oral antipsychotics are more effective for medication adherence and relapse prevention. Moreover, some clinical guidelines for the treatment of schizophrenia suggested that LAI antipsychotics should be considered when patients are nonadherent “at any stage.” Decreased compliance is a common cause of relapse during the initial stages of the disease. Therefore, LAI antipsychotics should be highly considered when treating patients with first-episode schizophrenia. In the present paper, clinical trial data and current guidelines on the use of LAI antipsychotics for first-episode schizophrenia are discussed as well as the pros and cons of this treatment option. PMID:22966439

Kim, Borah; Lee, Sang-Hyuk; Yang, Yen Kuang; Park, Jong-Il; Chung, Young-Chul

2012-01-01

370

Estereotipos Sexuales y su Relación con Conductas Sexuales Riesgosas1,2,3  

PubMed Central

Resumen Los estereotipos sexuales son creencias generalmente aceptadas y poco cuestionadas que podrían contribuir a cómo los hombres y las mujeres debemos expresar nuestra sexualidad. Los objetivos de este estudio eran identificar cuántos hombres y mujeres heterosexuales en Puerto Rico endosaban ciertos estereotipos acerca de la sexualidad masculina y femenina y explorar la relación entre el endoso de estos estereotipos sexuales y las actitudes hacia el condón masculino y su uso en relaciones sexuales vaginales Llevamos a cabo un estudio descriptivo-correlacional mediante el cual le administramos dos escalas, una sobre sexualidad masculina y otra sobre sexualidad femenina a un grupo de 429 personas heterosexuales. Encontramos que los hombres endosaron estereotipos sexuales masculinos y femeninos más que las mujeres y que estos tienden a tener una visión más conservadora respecto a la sexualidad femenina que la que tienen sobre su propia sexualidad. Las mujeres, por otra parte, tienden a ver su propia sexualidad y la sexualidad masculina en términos menos estereotipados y más equitativos. También encontramos que a mayor endoso de creencias tradicionales sobre la sexualidad masculina y femenina, peor la actitud hacia el uso del condón masculino. Sin embargo, el endosar estereotipos sexuales masculinos y/o femeninos no se relacionó con el uso del condón. Estos hallazgos contradicen la literatura que sugiere que estos estereotipos sexuales y de género resultan en conductas sexuales de alto riesgo, lo cual tiene implicaciones importantes para el desarrollo e implementación de programas de prevención. PMID:24575164

Pérez-Jiménez, David; Orengo-Aguayo, Rosaura E.

2012-01-01

371

Assessing ComSciCon 2013: A science communication workshop for STEM graduate students (Invited)  

NASA Astrophysics Data System (ADS)

We report on the efficacy of Communicating Science 2013, a science communication workshop for graduate students. Effective science communication is imperative for the sharing of scientific ideas, continued funding and support from policy makers, and education of the public. Science graduate students are a prime group to target for communication training, as they will be our future scientists, educators, and EPO professionals. To this end, Communicating Science 2013 (ComSciCon), a workshop organized by and for STEM graduate students, was held in June of this year. This workshop taught graduate students from around the nation to effectively communicate science to both their peers and the public. To learn about grad students' attitudes toward science communication and establish the workshop's efficacy, we surveyed the participants both before and after the workshop. This assessment probed topics such as communication preparation the participants have already received, how science communication is perceived in their home department, and what participants gained from the workshop. We report the results here.

Kohler, S.; Ranjan, S.; Sanders, N.; Morey, S.

2013-12-01

372

RAZA, COLOR, RELIGIN, SEXO, PROCEDENCIA El Ttulo VII de la Ley de Derechos Civiles (Civil Rights Act) de 1964, con sus modificaciones,  

E-print Network

Oportunidades en el Empleo (Equal Employment Opportunity Commission, EEOC) de actuar en representación suya y Discriminación Laboral por Edad (Age Discrimination in Employment Act) de 1967, con sus modificaciones, protege Igualdad en las Remuneraciones (Equal Pay Act) de 1963, con sus modificaciones, también prohíbe la

373

Problemas de rutas con ventanas de tiempo y carga y descarga simultanea: diseño de filtros en algoritmos de intercambio (caso de un vehículo)  

Microsoft Academic Search

En este trabajo se propone un método para diseñar algoritmos para el Problema de Rutas de Vehículos con Ventanas de Tiempo, y con Carga y Descarga simultánea (VRPTW mixto) basados en las conocidas técnicas de mejora o intercambio r-ópotimos. Este método consiste en incorporar un mecanismo que filtre los intercambios que van a dar lugar a rutas factibles. El resultado

Joaquín Antonio Pacheco Bonrostro; Cristina Rocio Delgado Serna

1997-01-01

374

Analytical studies of groundwater-head uctuation in a coastal conned aquifer overlain by a semi-permeable layer with storage  

E-print Network

Analytical studies of groundwater-head ¯uctuation in a coastal con®ned aquifer overlain by a semi are carried out to investigate groundwater-head changes in a coastal aquifer system in response to tidal and storage of the semi-permeable layer on the tide-induced groundwater-head ¯uctuation in the semi

Jiao, Jiu Jimmy

375

Estudio financiado por los NIH indica un aumento de la supervivencia en hombres con cáncer de próstata metastásico que reciben quimioterapia desde el inicio de la terapia hormonal  

Cancer.gov

Los hombres con cáncer de próstata metastásico sensible a las hormonas que recibieron el fármaco quimioterapéutico docetaxel al inicio de la terapia hormonal convencional vivieron más tiempo que los pacientes que recibieron solo terapia hormonal, de acuerdo con los resultados preliminares de un estudio clínico controlado y aleatorizado patrocinado por los Institutos Nacionales de la Salud (NIH).

376

Characterization Data Package for Containerized Sludge Samples Collected from Engineered Container SCS-CON-210  

SciTech Connect

This data package contains the K Basin sludge characterization results obtained by Pacific Northwest National Laboratory during processing and analysis of four sludge core samples collected from Engineered Container SCS-CON-210 in 2010 as requested by CH2M Hill Plateau Remediation Company. Sample processing requirements, analytes of interest, detection limits, and quality control sample requirements are defined in the KBC-33786, Rev. 2. The core processing scope included reconstitution of a sludge core sample distributed among four to six 4-L polypropylene bottles into a single container. The reconstituted core sample was then mixed and subsampled to support a variety of characterization activities. Additional core sludge subsamples were combined to prepare a container composite. The container composite was fractionated by wet sieving through a 2,000 micron mesh and a 500-micron mesh sieve. Each sieve fraction was sampled to support a suite of analyses. The core composite analysis scope included density determination, radioisotope analysis, and metals analysis, including the Waste Isolation Pilot Plant Hazardous Waste Facility Permit metals (with the exception of mercury). The container composite analysis included most of the core composite analysis scope plus particle size distribution, particle density, rheology, and crystalline phase identification. A summary of the received samples, core sample reconstitution and subsampling activities, container composite preparation and subsampling activities, physical properties, and analytical results are presented. Supporting data and documentation are provided in the appendices. There were no cases of sample or data loss and all of the available samples and data are reported as required by the Quality Assurance Project Plan/Sampling and Analysis Plan.

Fountain, Matthew S.; Fiskum, Sandra K.; Baldwin, David L.; Daniel, Richard C.; Bos, Stanley J.; Burns, Carolyn A.; Carlson, Clark D.; Coffey, Deborah S.; Delegard, Calvin H.; Edwards, Matthew K.; Greenwood, Lawrence R.; Neiner, Doinita; Oliver, Brian M.; Pool, Karl N.; Schmidt, Andrew J.; Shimskey, Rick W.; Sinkov, Sergey I.; Snow, Lanee A.; Soderquist, Chuck Z.; Thompson, Christopher J.; Trang-Le, Truc LT; Urie, Michael W.

2013-09-10

377

(Con)text-specific effects of visual dysfunction on reading in posterior cortical atrophy.  

PubMed

Reading deficits are a common early feature of the degenerative syndrome posterior cortical atrophy (PCA) but are poorly understood even at the single word level. The current study evaluated the reading accuracy and speed of 26 PCA patients, 17 typical Alzheimer's disease (tAD) patients and 14 healthy controls on a corpus of 192 single words in which the following perceptual properties were manipulated systematically: inter-letter spacing, font size, length, font type, case and confusability. PCA reading was significantly less accurate and slower than tAD patients and controls, with performance significantly adversely affected by increased letter spacing, size, length and font (cursive < non-cursive), and characterised by visual errors (69% of all error responses). By contrast, tAD and control accuracy rates were at or near ceiling, letter spacing was the only perceptual factor to influence reading speed in the same direction as controls, and, in contrast to PCA patients, control reading was faster for larger font sizes. The inverse size effect in PCA (less accurate reading of large than small font size print) was associated with lower grey matter volume in the right superior parietal lobule. Reading accuracy was associated with impairments of early visual (especially crowding), visuoperceptual and visuospatial processes. However, these deficits were not causally related to a universal impairment of reading as some patients showed preserved reading for small, unspaced words despite grave visual deficits. Rather, the impact of specific types of visual dysfunction on reading was found to be (con)text specific, being particularly evident for large, spaced, lengthy words. These findings improve the characterisation of dyslexia in PCA, shed light on the causative and associative factors, and provide clear direction for the development of reading aids and strategies to maximise and sustain reading ability in the early stages of disease. PMID:24841985

Yong, Keir X X; Shakespeare, Timothy J; Cash, Dave; Henley, Susie M D; Warren, Jason D; Crutch, Sebastian J

2014-08-01

378

The relationship between surface incline and con-focal chromatic aberration sensor response  

NASA Astrophysics Data System (ADS)

The limiting performance characteristics of con-focal chromatic aberration displacement sensors are angular tolerance and the gauge range over which an output is provided. The sensor selected in this study is used to measure groove profiles in early recorded surfaces. The sensor is used in a 3 dimensional cylinder scanning system for the measurement of wax cylinder recordings, where the 3 dimensional data is used to create a map of the measured surface for archival purposes. The generation of the map allows the sound recorded on the surface to be decoded without physical contact to the surface. It has been shown in a previous study that data resolution of 10-20nm are required for this application, and that the relationship between the data output and the surface incline is critical to system performance. To understand the relationship with surface slope the sensor is used here in a study of the measurement of calibration ball surfaces, and follows a previous study on machined grooves with known angular properties. In this study a range of calibration spherical surfaces are used to investigate the relationship between the sensor output and measurement parameters, including the distance between the sensor optical head and the surface. A linear least squares method is used to evaluate the 3D radius of the measured surfaces, and this is used as a parameter to evaluate the systematic errors. The results show that there is a low level of systematic form error typically below 1?m, but that this error has a significant impact on the evaluation of the radius. Recommendations are made on methods for optimisation of sensor performance.

McBride, J. W.; Boltryk, P. J.; Zhao, Z.

2007-07-01

379

(Con)text-specific effects of visual dysfunction on reading in posterior cortical atrophy  

PubMed Central

Reading deficits are a common early feature of the degenerative syndrome posterior cortical atrophy (PCA) but are poorly understood even at the single word level. The current study evaluated the reading accuracy and speed of 26 PCA patients, 17 typical Alzheimer's disease (tAD) patients and 14 healthy controls on a corpus of 192 single words in which the following perceptual properties were manipulated systematically: inter-letter spacing, font size, length, font type, case and confusability. PCA reading was significantly less accurate and slower than tAD patients and controls, with performance significantly adversely affected by increased letter spacing, size, length and font (cursive < non-cursive), and characterised by visual errors (69% of all error responses). By contrast, tAD and control accuracy rates were at or near ceiling, letter spacing was the only perceptual factor to influence reading speed in the same direction as controls, and, in contrast to PCA patients, control reading was faster for larger font sizes. The inverse size effect in PCA (less accurate reading of large than small font size print) was associated with lower grey matter volume in the right superior parietal lobule. Reading accuracy was associated with impairments of early visual (especially crowding), visuoperceptual and visuospatial processes. However, these deficits were not causally related to a universal impairment of reading as some patients showed preserved reading for small, unspaced words despite grave visual deficits. Rather, the impact of specific types of visual dysfunction on reading was found to be (con)text specific, being particularly evident for large, spaced, lengthy words. These findings improve the characterisation of dyslexia in PCA, shed light on the causative and associative factors, and provide clear direction for the development of reading aids and strategies to maximise and sustain reading ability in the early stages of disease. PMID:24841985

Yong, Keir X.X.; Shakespeare, Timothy J.; Cash, Dave; Henley, Susie M.D.; Warren, Jason D.; Crutch, Sebastian J.

2014-01-01

380

The politics of energy: Case study of Con Edison's nuclear complex at Indian Point, New York. Working paper  

Microsoft Academic Search

The possible impact of areawide residential location policy on future residential electricity usage in the Tri-State Metropolitan Region centering on New York City is investigated. This paper focuses on the politics of energy in its discussion of Con Edison's Nuclear Complex at Indian Point. The first period of planning (1954 to the late 60's) comprised a relatively closed decision-making process

J. Aron; K. Seelman

1974-01-01

381

Storm impacts along European coastlines. Part 1: The joint effort of the MICORE and ConHaz Projects  

Microsoft Academic Search

The current paper discusses the topic of marine storm impact along European coastlines, presenting results from two FP7 Projects currently focusing on this topic, one working on the physical aspects of the problem (MICORE) and the other one on the socio-economic implications (ConHaz).The MICORE Project aims to provide on-line predictions of storm-related physical hazards (hydrodynamic as well as morphodynamic). The

Paolo Ciavola; Oscar Ferreira; Piet Haerens; Mark Van Koningsveld; Clara Armaroli; Quentin Lequeux

2011-01-01

382

2Crateri lunari Quiz 1. Usando un righello con la scala in millimetri, qual' la scala di questa immagine  

E-print Network

2Crateri lunari Quiz 1. ­ Usando un righello con la scala in millimetri, qual'è la scala di questa, quindi se questa equivale ad una larghezza di 153 km, la scala dell'immagine è di 183 km/153 mm = 1.2 km/mm. Soluzione 2: Il diametro è di circa 85 mm che usando la scala dell'immagine equivale a 85 mm x 1.2 km

Christian, Eric

383

CHILES Con Pol: Probing galaxy evolution, the dark Universe, and cosmic magnetism with a deep 1000 hour Jansky VLA survey  

NASA Astrophysics Data System (ADS)

We recently started a 1000 hour campaign to observe 0.2 square degrees of the COSMOS field in full polarization continuum at 1.4 GHz with the Jansky VLA, as part of a joint program with the spectral line COSMOS HI Large Extragalactic Survey (CHILES). When complete, we expect our CHILES Continuum Polarization (CHILES Con Pol) survey to reach an unprecedented SKA-era sensitivity of 0.7 uJy per 4 arcsecond FWHM beam. Here we present the key goals of CHILES Con Pol, which are to (i) produce a source catalog of legacy value to the astronomical community, (ii) measure differential source counts in total intensity, linear polarization, and circular polarization in order to constrain the redshift and luminosity distributions of source populations, (iii) perform a novel weak lensing study using radio polarization as an indicator of intrinsic alignment to better study dark energy and dark matter, and (iv) probe the unknown origin of cosmic magnetism by measuring the strength and structure of intergalactic magnetic fields in the filaments of large scale structure. The CHILES Con Pol source catalog will be a useful resource for upcoming wide-field surveys by acting as a training set for machine learning algorithms, which can then be used to identify and classify radio sources in regions lacking deep multiwavelength coverage.

Hales, Christopher A.; Chiles Con Pol Collaboration

2014-04-01

384

Desarrollo de la Escala sobre el Estigma Relacionado con el VIH/SIDA para Profesionales de la Salud mediante el uso de métodos mixtos123  

PubMed Central

El estigma relacionado con el VIH/SIDA continúa siendo un obstáculo para la prevención primaria y secundaria del VIH. Las consecuencias para las personas que viven con la enfermedad han sido muy documentadas y continúan siendo una gran preocupación para las personas que proveen servicios de salud y para aquellas que investigan el tema. Estas consecuencias son preocupantes cuando el estigma emana de profesionales de la salud porque se puede limitar el acceso a los servicios. Uno de los principales obstáculos para la investigación del estigma relacionado con el VIH en Puerto Rico es la falta de instrumentos cuantitativos para evaluar las manifestaciones del estigma entre profesionales de la salud. El objetivo principal de este estudio fue desarrollar y probar las propiedades psicométricas de una escala sobre el estigma relacionado con el VIH/SIDA culturalmente apropiada para personas que proveen servicios de salud puertorriqueñas y desarrollar una versión corta de la escala que pudiera usarse en escenarios clínicos con tiempo limitado. El instrumento desarrollado estuvo basado en evidencia cualitativa recopilada entre profesionales y estudiantes de profesiones de la salud puertorriqueños/as (n=80) y administrado a una muestra de 421 profesionales de la salud en adiestramiento. La escala contenía 12 dimensiones del estigma relacionado con el VIH/SIDA. El análisis cuantitativo corroboró 11 de ellas, teniendo como resultado un instrumento con validez y confiabilidad satisfactoria. Estas dimensiones, a su vez, fueron subcomponentes de un factor de estigma general superior. PMID:20333258

Varas-Díaz, Nelson; Neilands, Torsten B.; Guilamo-Ramos, Vincent; Cintrón Bou, Francheska N.

2009-01-01

385

Fuentes de variabilidad en el diagnóstico de gastritis atrófica multifocal asociada con la infección por Helicobacter pylori1  

PubMed Central

RESUMEN Introducción El mapeo de las diferentes regiones del estómago y el número de fragmentos de mucosa gástrica disponibles para evaluación histopatológica son fuentes importantes de variación en el momento de clasificar y hacer la gradación de la gastritis crónica. Objetivos Estimar la sensibilidad del número de fragmentos de mucosa gástrica necesarios para establecer los diagnósticos de gastritis atrófica con metaplasia intestinal (MI), displasia y estado de infección por Helicobacter pylori. Además evaluar la variabilidad intra-observador en la clasificación de estas lesiones precursoras del cáncer gástrico. Materiales y métodos En una cohorte de 6 años de seguimiento se evaluaron 1,958 procedimientos de endoscopia realizados por dos gastroenterólogos. En cada procedimiento y de cada participante se obtuvieron 5 biopsias de mucosa gástrica que representaban antro, incisura angularis y cuerpo. Un único patólogo hizo la interpretación histológica de las 5 biopsias y proporcionó un diagnóstico definitivo global que se utilizó como patrón de referencia. Cada fragmento de mucosa gástrica examinado condujo a un diagnóstico individual para cada biopsia que se comparó con el patrón de referencia. La variabilidad intra-observador se evaluó en 127 personas que corresponden a una muestra aleatoria de 20% del total de endoscopias hechas a los 72 meses de seguimiento. Resultados La sensibilidad del diagnóstico de MI y displasia gástrica aumentó de manera significativa con el número de fragmentos de mucosa gástrica evaluados El sitio anatómico de mayor sensibilidad para el diagnóstico de MI y displasia fue la incisura angularis. Para descubrir H. pylori se logró alta sensibilidad con el estudio de un solo fragmento de mucosa gástrica (95.9%) y fue independiente del sitio de obtención de la biopsia. El acuerdo intra-observador para el diagnóstico de gastritis crónica fue 86.1% con valor kappa de 0.79 IC 95% (0.76-0.85). Las biopsias fijadas en alcohol fueron inadecuadas para demostrar H. pylori e interpretar los cambios de displasia. Conclusión El número de fragmentos de mucosa gástrica evaluados, el método de fijación y la región del estómago donde se obtienen las biopsias son factores muy importantes para lograr una correcta clasificación de la gastritis crónica atrófica multifocal. PMID:25267864

Bravo, Luis Eduardo; Bravo, Juan Carlos; Realpe, José Luis; Zarama, Guillermo; Piazuelo, MarÍa Blanca; Correa, Pelayo

2014-01-01

386

Collaborazione con il Cinema Mexico di Milano (1) Il Cinema Mexico di Via Savona n 57 Milano ha una programmazione caratterizzata da  

E-print Network

Collaborazione con il Cinema Mexico di Milano (1) Il Cinema Mexico di Via Savona n° 57 ­ Milano ha' CICLISTICA MILANESE tutti i lunedì biglietto ridotto a 4 euro, per tutti coloro che si recano al cinema

De Cindio, Fiorella

387

ESERCIZI Sulla stima dell'errore di integrazione del 20/11/08 1. Applica il metodo di Simpson con h = 1  

E-print Network

1 ESERCIZI Sulla stima dell'errore di integrazione del 20/11/08 1. Applica il metodo di Simpson con dei trapezi e il meto- do di Simpson per approssimare questo integrale e applica l'estrapo- lazione di

Guerrini, Carla

388

Con motivo de la visita a Espaa del presidente de la Rep-blica Popular China, Hu Jintao, el rector de la Universidad  

E-print Network

exámenes, tra- ducción e interpretación, turismo, comercio, banca y medici- na tradicional china Internacional, Liu Bin, y contaba, entre otros, con los rectores de las universidades Jiaotong de Beijing

Autonoma de Madrid, Universidad

389

Antidepressant-like effect of Canavalia brasiliensis (ConBr) lectin in mice: evidence for the involvement of the glutamatergic system.  

PubMed

Lectins recognize and reversibly bind to carbohydrates attached to proteins and lipids modulating a variety of signaling pathways. We previously showed that ConBr, a lectin from Canavalia brasiliensis seeds, produced an antidepressant-like effect in mice by modulating the monoaminergic neurotransmitter systems. Moreover, ConBr blocked hippocampal neurotoxicity induced by quinolinic acid in vivo and by glutamate in vitro, suggesting a neuroprotective activity of ConBr via glutamatergic system modulation. Therefore, the present study was undertaken to investigate the involvement of the N-methyl-D-aspartate (NMDA) receptor and the L-arginine-nitric oxide (NO) pathway in the antidepressant-like action displayed by ConBr in the forced swimming test (FST). With the aim of verifying the involvement of NMDA receptors in the antidepressant-like effect of ConBr (10 ?g/site, i.c.v.), an intracerebroventricular (i.c.v.) pretreatment with either NMDA (0.1 pmol/site) or D-serine (30 ?g/site) was carried out. The results show that both treatments blocked the effect of ConBr. Furthermore, the coadministration of subeffective doses of the NMDA receptor antagonist MK-801 (0.001 mg/kg, i.p.) or ketamine (0.1 mg/kg, i.p.; NMDA receptor antagonist) and ConBr (0.1 ?g/site, i.c.v.) caused a synergistic reduction in immobility time. In order to verify the dependence of the L-arginine-NO-cGMP pathway, on the effect of ConBr in the FST, a pretreatment with the NO precursor, L-arginine (750 mg/kg, i.p.), or the PDE5 inhibitor, sildenafil (5 mg/kg, i.p.), was performed. Both drugs abolished the antidepressant-like action of ConBr. Finally, the administration of subeffective doses of the soluble guanylate cyclase inhibitor 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one (ODQ; 30 pmol/site, i.c.v.) and ConBr (0.1 ?g/site, i.c.v.) produced a synergistic antidepressant-like effect in the FST. Taken together, the results suggest that the antidepressant-like effect of ConBr in the FST involves NMDA receptor inhibition and reduction in NO and cGMP synthesis. PMID:24650588

Rieger, Débora K; Costa, Ana Paula; Budni, Josiane; Moretti, Morgana; Barbosa, Sabrina Giovana Rocha; Nascimento, Kyria S; Teixeira, Edson H; Cavada, Benildo S; Rodrigues, Ana Lúcia S; Leal, Rodrigo B

2014-07-01

390

"Estudio tribologico de aceros para moldes. Aplicacion al moldeo por inyeccion de polibutilentereftalato reforzado con fibra de vidrio"  

NASA Astrophysics Data System (ADS)

Mould materials for injection moulding of polymers and polymer-matrix composites represent a relevant industrial economic sector due to the large quantity of pieces and components processed. The material selection for mould manufacturing, its composition and heat treatment, the hardening procedures and machining and finishing processes determine the service performance and life of the mould. In the first part of the present study, the relationship between the hardness and microstructure and the wear resistance of mould steels from large blocks has been studied by pin-on-disc tests, studying the main wear mechanisms. In order to determine the surface damage on mould steels under real injection conditions, different commercial steels have been studied by measuring the variation of surface roughness with the number of injected pieces with different reinforcement percentages and different mould geometries, by using optical profilometry and scanning electron microscopy techniques. It was important to determine the variation of surface roughness of the moulded pieces with the number of injection operations. The materials used were polybutyleneterephthalate pure and reinforced with either 20% or 50% glass fibre. For the different mould designs, the evolution of the glass fibre orientation with injection flow has been determined by image analysis and related to roughness changes and surface damage, both of the composite parts and of the mould steel surface. Finally, the abrasion resistance of the composite parts has been studied by scratch tests as a function of the number of injected parts and of the scratch direction with respect to injection flow and glass fibre orientation. Los materiales para moldes de inyeccion de polimeros y materiales compuestos representan un sector economicamente muy relevante debido al gran aumento del numero de componentes fabricados a partir de materiales polimericos obtenidos mediante moldeo por inyeccion. La seleccion del material para la fabricacion del molde, tienen una gran influencia sobre su comportamiento en servicio a lo largo de la vida util del molde. En la primera parte del presente estudio, a partir de ensayos punzon sobre disco, se ha determinado la relacion entre la resistencia al desgaste y la dureza de aceros para moldes obtenidos a partir de bloques de gran espesor, estudiando los principales mecanismos de desgaste que tienen lugar. A continuacion, con el fin de determinar el dano superficial que sufren los aceros para moldes en condiciones reales de inyeccion, se han estudiado distintos tipos de aceros utilizados comercialmente en moldes de inyeccion de polimeros y materiales compuestos, seleccionando las condiciones de operacion para determinar la variacion de la rugosidad superficial del acero en funcion del material inyectado, del numero de operaciones sucesivas de inyeccion y de la orientacion del flujo de inyeccion, mediante tecnicas de perfilometria optica y microscopia electronica de barrido. Ademas del dano superficial sufrido por el acero con el numero de piezas inyectadas, tambien se ha determinado la evolucion de la rugosidad superficial de los materiales inyectados, polibutilentereftalato (PBT) puro y materiales compuestos derivados de PBT por adicion de un 20 o un 50% en peso de fibra de vidrio. En el caso de las piezas inyectadas, se ha caracterizado su microestructura en funcion del flujo de inyeccion y de la densidad de fibra, se han determinado sus propiedades termicas y dinamico-mecanicas, asi como la variacion de la rugosidad superficial de las piezas inyectadas con el numero de operaciones de inyeccion y con la geometria de las distintas secciones de las piezas. Finalmente, se ha evaluado la resistencia a la abrasion de PBT reforzado con un 50% de fibra, en funcion del numero de piezas inyectadas y de la direccion de rayado con respecto a la orientacion del flujo de inyeccion.

Martinez Mateo, Isidoro Jose

391

Nanoparticulas basadas en complejos de Fe(II) con transicion de espin: sintesis, caracterizacion y aplicaciones en electronica molecular  

NASA Astrophysics Data System (ADS)

Esta tesis doctoral esta organizada en 5 capitulos y esta destinada al estudio de sistemas de Fe (II) que presentan el fenomeno de la transicion de espin a escala nanometrica. El capitulo 1 contiene una introduccion general sobre materiales moleculares multifuncionales, destacando aquellos ejemplos mas importantes. Por otro lado, se explicara el fenomeno de la transicion de espin, tratando aspectos conceptuales, los antecedentes mas importantes y la situacion actual. En el capitulo 2 se describen los diferentes procesos existentes para la obtencion de diferentes tipos de nanoparticulas. Ademas, se presenta la sintesis y caracterizacion de nanoparticulas del polimero de coordinacion unidimensional [Fe(Htrz)2(trz)]BF4, obtenidas mediante el metodo de micelas inversas. Estas nanoparticulas, con una estrecha distribucion de tamanos centrada alrededor de los 11 nm, presentan una transicion de espin muy abrupta, con un ancho ciclo de histeresis termica de unos 40K. En el capitulo 3 se describe el proceso de modificacion del tamano de las nanoparticulas descritas en el capitulo anterior, llevado a cabo variando la proporcion de surfactante/H2O en el medio. Ademas, con el objetivo de modificar las propiedades magneticas de las nanoparticulas obtenidas en el capitulo 2, se lleva a cabo la sintesis de nanoparticulas de polimeros de la misma familia del [Fe(Htrz)2(trz)]BF4. En concreto se sintetizaron 3 nuevos tipos de nanoparticulas basadas en el polimero [Fe(Htrz)1-x(NH2trz)x](ClO4)2, siendo x = 0.05, 0.15 y 0.3, en cada caso. Estas nanoparticulas siguen presentando una estrecha distribucion de tamanos y una transicion de espin muy abrupta y con un ancho ciclo de histeresis. Ademas, se observa que este ciclo se desplaza a temperaturas mas proximas a la temperatura ambiente a medida que se aumenta el porcentaje de 4-amino-1, 2, 4- triazol en la muestra. Pero al mismo tiempo se produce una disminucion de la anchura de este ciclo. Por ultimo, en este capitulo se presenta la sintesis de otro nuevo tipo de nanoparticulas, obtenidas a partir de otro polimero de la misma familia, el [FeO8ZnO2(Htrz)3](BF4). Estas nanoparticulas se sintetizaron con el objetivo de estudiar el efecto de la dilucion del metal en la muestra. Como resultado se obtuvieron nanoparticulas que tambien presentan una estrecha distribucion de tamanos pero en este caso la transicion de espin no es tan abrupta como en los casos anteriores. Aunque sigue presentando un ciclo de histeresis termica bastante ancho y a temperaturas proximas a la temperatura ambiente. En el capitulo 4 se describiran las estrategias que se han seguido para mejorar la estabilidad y afinidad sobre diferentes sustratos de las nanoparticulas sintetizadas en el capitulo 2. Tambien se hablara de los intentos realizados parar depositarlas en superficies y embeberlas en diferentes matrices organicas e inorganicas. En el capitulo 5 presentaremos la obtencion de un interruptor molecular realizado poniendo en contacto nanoparticulas individuales sintetizadas en el capitulo 2, con unos electrodos separados varios nanometros. Este dispositivo exhibe "switching" y efecto memoria a temperaturas proximas a la temperatura ambiente como consecuencia de la biestabilidad intrinseca de las nanoparticulas. Ademas demostraremos que el estado magnetico de estas nanoparticulas puede ser controlado electricamente, ya que la transicion de espin en este nanodispositivo molecular puede ser inducida simplemente aplicando un voltaje, lo que puede ser de gran interes para la electronica molecular.

Monrabal Capilla, Maria

392

El seminario consta de dos partes independientes: Una primera parte o Seminario terico con el ttulo Comprendiendo elTDA-H y una segunda  

E-print Network

realizará de manera práctica, tutorizada por un profesional en ejercicio especialista en TDAH con el título.La realización de ambos,llevará a la inclu- sión en un grupo de colaboradores con formación específica enTDAH: · AnalizarlarealidaddelossujetosconTDAH,desdesuprimera infancia hasta la entrada en la edad adulta

Escolano, Francisco

393

Influence of parameter values and variances and algorithm architecture in ConsExpo model on modeled exposures.  

PubMed

This study evaluated the influence of parameter values and variances and model architecture on modeled exposures, and identified important data gaps that influence lack-of-knowledge-related uncertainty, using Consexpo 4.1 as an illustrative case study. Understanding the influential determinants in exposure estimates enables more informed and appropriate use of this model and the resulting exposure estimates. In exploring the influence of parameter placement in an algorithm and of the values and variances chosen to characterize the parameters within ConsExpo, "sensitive" and "important" parameters were identified: product amount, weight fraction, exposure duration, exposure time, and ventilation rate were deemed "important," or "always sensitive." With this awareness, exposure assessors can strategically focus on acquiring the most robust estimates for these parameters. ConsExpo relies predominantly on three algorithms to assess the default scenarios: inhalation vapors evaporation equation using the Langmuir mass transfer, the dermal instant application with diffusion through the skin, and the oral ingestion by direct uptake algorithm. These algorithms, which do not necessarily render health conservative estimates, account for 87, 89 and 59% of the inhalation, dermal and oral default scenario assessments,respectively, according them greater influence relative to the less frequently used algorithms. Default data provided in ConsExpo may be useful to initiate assessments, but are insufficient for determining exposure acceptability or setting policy, as parameters defined by highly uncertain values produce biased estimates that may not be health conservative. Furthermore, this lack-of-knowledge uncertainty makes the magnitude of this bias uncertain. Significant data gaps persist for product amount, exposure time, and exposure duration. These "important" parameters exert influence in requiring broad values and variances to account for their uncertainty. Prioritizing them for research will not only help fill a large and influential knowledge gap, but also lead to more accurate assessments and thus refine the studies informing policy decisions. PMID:24283337

Arnold, Susan F; Ramachandran, Gurumurthy

2014-01-01

394

Pros and Cons of Using Arrays of Small Antennas Versus Large Single Dish Antennas for the Deep Space Network  

NASA Technical Reports Server (NTRS)

This paper briefly describes pros and cons of using arrays of small antennas instead of large single dish antennas for spacecraft telemetry, command, and tracking (TT and C) - communications and navigation (C and N) - and science support that the Deep Space Network (DSN) normally provides. It considers functionality and performance aspects, mainly for TT and C, though it also considers science. It only briefly comments on the cost aspects that seem to favor arrays of small antennas over large single antennas, at least for receiving (downlinks).

Bagri, Durgadas S.

2009-01-01

395

Dinámica y frecuencias características de una protuberancia solar observada con los instrumentos SUMER y CDS/SOHO  

NASA Astrophysics Data System (ADS)

La estructura de la protuberancia estudiada puede dividirse en cuatro regiones. A partir del análisis de las imágenes del CDS y los espectros del SUMER utilizando técnicas de multiresolución con Wavelets se obtuvieron las frecuencias y velocidades relativas de cada una de las regiones. Se observan frecuencias características del orden de los 5 min y otras de largo período. Se obtuvo una fuerte anticorrelación entre las intensidades y las velocidades Doppler. La presencia de las oscilaciones de 5 min en todas las regiones sugieren el acoplamiento entre la estructura cromosférica y la protuberancia.

Rovira, M.; Costa, A.; Bocchialini, K.

396

Modelo de accesibilidad de conceptos matematicos aplicados en el curso de Astronomia Descriptiva para estudiantes con impedimentos visuales en la UPR  

NASA Astrophysics Data System (ADS)

Este estudio utiliza metodologia de investigacion cualitativa, con el proposito de describir, analizar y evaluar los procesos de diseno y desarrollo de un modelo de accesibilidad que consiste en estrategias de ensenanza de las matematicas para estudiantes con impedimentos visuales matriculados en el curso de Astronomia Descriptiva en la UPR. Se utilizaron las siguientes estrategias para recopilar la informacion, 1) reflexiones de la investigadora en el proceso de diseno y desarrollo de las lecciones adaptadas, que se registraron en un diario reflexivo. 2) entrevista semiestructurada luego de haber trabajado las lecciones de aprendizaje adaptadas con los participantes. 3) observaciones y notas de la investigadora del trabajo de los participantes. Para obtener la informacion de los participantes se obtuvo los permisos institucionales necesarios; se seleccionaron los participantes y se validaron los instrumentos; se realizo el desarrollo de las lecciones adaptadas con los participantes; y finalmente, se analizo la informacion obtenida. El diseno de las lecciones de aprendizaje adaptadas se hizo siguiendo las recomendaciones curriculares de los temas de matematicas aplicados en el curso de Astronomia Descriptiva realizado por la investigadora durante su semestre de internado. El testimonio de las voces de los participantes se obtuvo del proceso de desarrollo de las lecciones de aprendizaje adaptadas de temas seleccionados de conceptos matematicos requeridos en el curso de Astronomia Descriptiva y de la entrevista semiestructurada con los participantes, luego de haber trabajado las lecciones de aprendizaje. Para el desarrollo de las lecciones de aprendizaje, se utilizaron materiales tactiles adaptados, materiales tactiles disenados y materiales disponibles comercialmente. Los textos de las lecciones se imprimieron en tinta y en Braille. Se exhorta a disenar y desarrollar estrategias de ensenanza accesibles, considerando como recursos para evaluar su efectividad a personas con impedimentos visuales. El utilizar estrategias de aprendizaje accesibles de acuerdo a las necesidades individuales de los estudiantes, contribuye para que los estudiantes con impedimentos visuales descubran, exploren, investiguen y formulen sus propias conclusiones durante su proceso de aprendizaje.

Isidro Villamizar, Gloria Maria

397

Protective Effects of Astaxanthin on ConA-Induced Autoimmune Hepatitis by the JNK/p-JNK Pathway-Mediated Inhibition of Autophagy and Apoptosis  

PubMed Central

Objective Astaxanthin, a potent antioxidant, exhibits a wide range of biological activities, including antioxidant, atherosclerosis and antitumor activities. However, its effect on concanavalin A (ConA)-induced autoimmune hepatitis remains unclear. The aim of this study was to investigate the protective effects of astaxanthin on ConA-induced hepatitis in mice, and to elucidate the mechanisms of regulation. Materials and Methods Autoimmune hepatitis was induced in in Balb/C mice using ConA (25 mg/kg), and astaxanthin was orally administered daily at two doses (20 mg/kg and 40 mg/kg) for 14 days before ConA injection. Levels of serum liver enzymes and the histopathology of inflammatory cytokines and other maker proteins were determined at three time points (2, 8 and 24 h). Primary hepatocytes were pretreated with astaxanthin (80 ?M) in vitro 24 h before stimulation with TNF-? (10 ng/ml). The apoptosis rate and related protein expression were determined 24 h after the administration of TNF-?. Results Astaxanthin attenuated serum liver enzymes and pathological damage by reducing the release of inflammatory factors. It performed anti-apoptotic effects via the descending phosphorylation of Bcl-2 through the down-regulation of the JNK/p-JNK pathway. Conclusion This research firstly expounded that astaxanthin reduced immune liver injury in ConA-induced autoimmune hepatitis. The mode of action appears to be downregulation of JNK/p-JNK-mediated apoptosis and autophagy. PMID:25761053

Liu, Tong; Wang, Junshan; Dai, Weiqi; Wang, Fan; Zheng, Yuanyuan; Chen, Kan; Li, Sainan; Abudumijiti, Huerxidan; Zhou, Zheng; Wang, Jianrong; Lu, Wenxia; Zhu, Rong; Yang, Jing; Zhang, Huawei; Yin, Qin; Wang, Chengfen; Zhou, Yuqing; Lu, Jie; Zhou, Yingqun; Guo, Chuanyong

2015-01-01

398

ON EFFECT OF HAZARD MAP ON CONS CIOUSNESS OF FLOOD DISASTER PREVENSION OF RESIDENTS WHO EXPERIENCED FLOOD RECENTLY  

NASA Astrophysics Data System (ADS)

In this paper, the effect of the flood hazard map distributed to the residents who experienced flood disasters recently and an effective method for improving consciousness of flood di saster prevention are discussed. The questionnaire surveys were conducted on the residents living in the middle basin of the Nishiki River, Iwakuni city, Yamaguchi Prefecture, before and after the distribution of the hazard map. It is found from this investigation that "knowledge", "att achment", and "crisis", are the main factors in the psychological process related to the flood prevention behavior. The effect of the distribution of the hazard map is judged from the probability of the flood prevention behavior. In addition, it is also found that "knowledge", "flood experiment of T0514", "crisis", "eff ectiveness", "load", and "easy reading of the hazard map", are keys to improve the cons ciousness of flood di saster prevention.

Asai, Koji; Koga, Syota; Sakakibara, Hiroyuki

399

Concepciones Alternativas de "Fotosintesis" en estudiantes Universitarios del curso basico de Biologia y posibles correcciones con el Modelo Educativo MODEF  

NASA Astrophysics Data System (ADS)

Concepciones Alternativas de Fotosíntesis en estudiantes Universitariosdel curso básico de Biología y posibles correcciones con el Modelo Educativo MODEF El modelo educativo para la enseñanza de Fotosíntesis (MODEF) se implantó para trabajar el problema de las concepciones alternativas (CA) en un curso de Biología General. Se evaluaron los resultados en cuanto al logro del aprendizaje significativo. La pregunta central de la investigación fue: ¿Cómo aporta el modelo educativo en la didáctica y comprensión del tema de fotosíntesis? Se efectuó una investigación acción con una fase cuantitativa y una cualitativa. Para la fase cuantitativa se elaboró una prueba para determinar las concepciones alternativas, se validó y se sometió a los estudiantes que participaron en el estudio antes y después de ofrecer la unidad de metabolismo celular. Los participantes eran estudiantes de primer año de la Universidad de Puerto Rico en Bayamón (UPRB). Se llevó a cabo un análisis de consistencia interna de la prueba mediante el método Alfa de Cronbach. Se analizaron las contestaciones a cada pregunta mediante la prueba de Ji cuadrado de contingencia, se efectuó la prueba de t y el coeficiente r de Pearson. La fase cualitativa incluyó la observación participativa de la investigadora- profesora, las reflexiones de los estudiantes y la información de las entrevistas semi-estructuradas que se realizaron a tres estudiantes del curso. El análisis se llevó a cabo mediante el Modelo de Wolcott. Se trabajaron diez CA de las cuales siete fueron corregidas mediante el Modelo MODEF. Las actividades más importantes para el proceso de aprendizaje incluyeron el trabajo de investigación o búsqueda de información para hacer una presentación digital, la elaboración de tablas, los mapas de conceptos, el uso de visuales o videos y las analogías para explicar conceptos o procesos. En conclusión: se recomienda el uso del Modelo MODEF para la discusión del tema de Fotosíntesis a base de los resultados cuantitativos y cualitativos de esta investigación. El Comité Institucional para la Protección de los Seres Humanos en la Investigación (CIPSHI) autorizó el estudio.

De Jesus Roman, Sandra

400

Intraspecific alkaloid variation in ladybird eggs and its effects on con- and hetero-specific intraguild predators.  

PubMed

Egg predation and cannibalism are common phenomena in predatory ladybirds despite the presence of defensive alkaloids. Consumption of heterospecific eggs negatively affects survivorship and development; however, intraspecific variation in quantities of alkaloids and post-ingestion responses to con- and hetero-specific alkaloids, are not well understood. We examined variation in the quantity of alkaloids in eggs of Harmonia axyridis (Pallas), Coccinella septempunctata L., and Hippodamia convergens (Guérin) using gas chromatography-mass spectrometry, and show a link between heterospecific alkaloids and their toxicity and/or costs by feeding high and low alkaloid eggs to first instar H. axyridis and C. septempunctata. The repeatability of alkaloid measurements in eggs in an egg cluster was high; however, the amount of alkaloids varied significantly between egg clutches within and among females. This variation affected egg consumption by C. septempunctata when fed H. axyridis eggs. Harmonia axyridis accumulated their own alkaloid by cannibalism and synthesized it de novo, but C. septempunctata lost some portion of the consumed conspecific alkaloids. Both species lost most of the consumed heterospecific alkaloids, but C. septempunctata died within 3 days. Most H. axyridis survived to the second instar, but C. septempunctata alkaloids led to a significant reduction in weight gain compared to an aphid control. In addition, ingestion of high alkaloid C. septempunctata extended development of H. axyridis compared to the aphid control or conspecific eggs. Harmonia axyridis had greater abilities to process ingested con- and hetero-specific alkaloids compared with C. septempunctata, which may, in part, explain their interspecific interactions in nature. PMID:20049478

Kajita, Yukie; Obrycki, J J; Sloggett, J J; Haynes, K F

2010-06-01

401

Nitrogen oxides and carbon chain oxides formed after ion irradiation of CO:N2 ice mixtures  

NASA Astrophysics Data System (ADS)

Context. High CO depletion as well as depletion of N-bearing species is observed in dense pre-stellar cores. It is generally accepted that depleted species freeze out onto dust grains to form icy mantles and that these ices suffer energetic processing due to cosmic ion irradiation and ion-induced UV photons. Aims: The aim of this work is to study the chemical and structural effects induced by ion irradiation on different CO:N2 mixtures at low temperature (16 K) to simulate the effects of cosmic ion irradiation of icy mantles. Methods: Different CO:N2 mixtures and pure CO and pure N2 were irradiated with 200 keV H+ at 16 K. Infrared transmittance spectra of the samples were obtained in situ before and after irradiation. The samples were warmed up and spectra were taken at different temperatures. The residues left over on the substrate at room temperature were analysed ex situ by micro Raman spectroscopy. Results: Several new absorption features are present in the infrared spectra after irradiation, indicating that new species are formed. The most abundant are nitrogen oxides (such as NO, NO2 and N2O), carbon chain oxides (such as C2O, C3O and C3O2), carbon chains (such as C3 and C6), O3 and N3. A refractory residue is also formed after ion irradiation and is clearly detected by Raman spectroscopy. Conclusions: We suggest that carbon chains and nitrogen oxides observed in the gas phase towards star-forming regions are formed in the solid phase after cosmic ion irradiation of icy grain mantles and are released into the gas phase after desorption of grain mantles. We expect that the Atacama Large Millimeter/submillimeter Array (ALMA), thanks to its high sensitivity and resolution, will increase the number of nitrogen oxides and carbon chain oxides detected towards star-forming regions.

Sicilia, D.; Ioppolo, S.; Vindigni, T.; Baratta, G. A.; Palumbo, M. E.

2012-07-01

402

Lectin from Canavalia brasiliensis (ConBr) protects hippocampal slices against glutamate neurotoxicity in a manner dependent of PI3K/Akt pathway.  

PubMed

The excitotoxicity induced by excessive activation of the glutamatergic neurotransmission pathway is involved in several neuropathologies. In this sense, molecules that prevent the release of glutamate or the excessive activation of its receptors can be useful in preventing the neuronal cell death observed in these diseases. Lectins are proteins capable of reversible binding to the carbohydrates in glycoconjugates, and some have been used in the study and purification of glutamate receptors. ConBr is a mannose/glucose-binding lectin purified from Canavalia brasiliensis seeds. In the present study, we aimed to evaluate the neuroprotective activity of ConBr against glutamate-induced excitotoxicity. Hippocampal slices were isolated from adult male mice and incubated for 6h in Krebs saline/DMEM buffer alone (control), in the presence of glutamate or glutamate plus ConBr. The phosphorylation of Akt and mitogen activated protein kinases (MAPKs) such as ERK1/2, p38(MAPK) and JNK1/2/3 was evaluated with western blotting. The results indicate that glutamate provoked a reduction in the hippocampal slice viability (-25%), diminished the phosphorylation of Akt and augmented p38(MAPK) and ERK1 phosphorylation. No changes were observed in the phosphorylation of JNK1/2/3 or ERK2. Notably, ConBr, through a mechanism dependent on carbohydrate interaction, prevented the reduction of cell viability and Akt phosphorylation induced by glutamate. Furthermore, in the presence of the PI3K inhibitor LY294002, ConBr was unable to reverse glutamate neurotoxicity. Taken together, our data suggest that the neuroprotective effect of ConBr against glutamate neurotoxicity requires oligosaccharide interaction and is dependent on the PI3K/Akt pathway. PMID:23454192

Jacques, Amanda V; Rieger, Débora K; Maestri, Mariana; Lopes, Mark W; Peres, Tanara V; Gonçalves, Filipe M; Pedro, Daniela Z; Tasca, Carla I; López, Manuela G; Egea, Javier; Nascimento, Kyria S; Cavada, Benildo S; Leal, Rodrigo B

2013-05-01

403

La funzione diastolica: studio ecocardiografico e significato clinico The diastolic function: an echocardiographic study and its clinical meaning  

Microsoft Academic Search

The diastolic function: an echocardiographic study and its clinical meaning. O. Serafini, G. Misuraca. Many patients with manifestations and\\/or symptoms of heart failure show a normal or only slight depressed sys- tolic function of the left ventricle. The origin of these symp- toms is attributed to anomalies of the diastolic function and the echocardiography has became an important technique for

Oscar Serafini; Gianfranco Misuraca

404

Extensive cortico-subcortical lesions in Wilson’s disease: clinico-pathological study of two cases  

Microsoft Academic Search

Wilson’s disease (WD) with extensive cortico-subcortical lesions represents a rare neuropathological subgroup, the pathogenesis of which is not clearly determined. We report two new cases with identical lesions. In the families of each of the patient, there were mutations in the ATPase7B gene, especially in the family of proband 1, and in the first cousin of proband 2. These cases

Jacqueline Mikol; Claude Vital; Michel Wassef; Philippe Chappuis; Joël Poupon; Monique Lecharpentier

2005-01-01

405

[Audit of clinical records: clinico-microbiologic study of urinary infections in a team of primary care].  

PubMed

To carry out an audit of clinical records in our center for the evaluation of the quality of care before the introduction of protocols, several prevalent conditions were selected, and among them urinary tract infections (UTI). Another aim of the study was to evaluate the autochthonous flora responsible for UTI and its resistence to commonly used antimicrobials. A series of acceptable criteria and standards were set as quality controls, and the real index was found below the preselected one in all cases. The most commonly isolated organism was E. coli, followed by Proteus, which were resistent to trimetoprim-sulfamethoxazole in 56% and 71.4% of cases, respectively. Problems of organization and knowledge, and a high resistence rate to common antimicrobials were detected; the following were suggested as measures for improvement: introduction of a protocol, need for continuing education, reduction in the care demand, health education and improvement in the antibiotic policy. PMID:2518879

Blázquez Ballesteros, M L; González López, E; Calvo García, E; Kloppe Villegas, P; Martín-Rabadán Muro, M; Ruiz de Adana Pérez, R

1989-01-01

406

An eight-year snapshot of geospatial cancer research (2002–2009): clinico-epidemiological and methodological findings and trends  

Microsoft Academic Search

Geographic information systems (GIS) offer a very rich toolbox of methods and technologies, and powerful research tools that\\u000a extend far beyond the mere production of maps, making it possible to cross-link and study the complex interaction of disease\\u000a data and factors originating from a wide range of disparate sources. Despite their potential indispensable role in cancer\\u000a prevention and control programmes,

Dina N. Kamel Boulos; Ramy R. Ghali; Ezzeldin M. Ibrahim; Maged N. Kamel Boulos; Philip AbdelMalik

407

Clinico-Pathologic Function of Cerebral ABC Transporters – Implications for the Pathogenesis of Alzheimer’s Disease  

PubMed Central

In recent years it has become evident that ABC transporters fulfill important barrier functions in normal organs and during disease processes. Most importantly, resistance to drugs in cancer cells led to intense oncological and pharmacological investigations in which researchers were able to highlight important pharmacological interactions of chemotherapeuticals with ABC transporter function. Recently, the development of neurodegenerative diseases and the maintenance of neuronal stem cells have been linked to the activity of ABC transporters. Here, we summarize findings from cell culture experiments, animal models and studies of patients with Alzheimer’s disease. Furthermore, we discuss pharmacological interactions and computational methods for risk assessment. PMID:18690837

Pahnke, Jens; Wolkenhauer, Olaf; Krohn, Markus; Walker, Lary C.

2009-01-01

408

Clinico-Pathological Correlation of ?-Catenin and Telomere Dysfunction in Head and Neck Squamous Cell Carcinoma Patients  

PubMed Central

Background: Tumorigenesis is a complex process of accumulated alteration in function of multiple genes and pathways. Wnt signalling pathway is involved in various differentiation events during embryonic development and is conserved in various species. Objective: A multicentre collaborative initiative is undertaken to study the occurrence, prognosis and molecular mechanism of HNSCC (Head and Neck Squamous Cell Carcinoma) which is highly prevalent in eastern parts of India. From a large cohort of HNSCC tissue repository, 67 cases were selected for multi-parametric investigation. Results: 67 cases showed stable ?-catenin expression. We have seen correlation, if any, of the transcription factor - ?-catenin, telomere maintenance and shelterin complex proteins - TRF2, Rap1 and hTert with respect to tumor differentiation and telomere dysfunction. Immunohistochemistry of ?-catenin protein showed stable and high expression in tumor when compared to stroma. MDSCC (Moderately Differentiated Squamous cell carcinoma) cases expressed nuclear expression of ?-catenin in invasive fronts and showed increased genomic instability. Higher frequency of Anaphase bridges was observed ranging from <3% in normal cut margin to 13% in WDSCC (Well differentiated squamous cell carcinoma) and 18% in MDSCC (Moderately differentiated Squamous cell carcinoma). There was significant decrease in telomere length in MDSCC (<4) when compared to the normal cut margin samples (<7). Quantitative Real Time-PCR confirmed a significant correlationship between stable ?-catenin expression and poor clinical and pathological outcome. Conclusion: The Stabilisation and accumulation of ?-catenin was significant and correlated well with de-differentiation process as well as prognosis and therapy outcome of the patients in the cohort. Expression status of molecular markers such as ?-catenin, hTert, TRF2 and RAP1 correlate significantly with the process of tumorigenesis and prognosis and may play a role in therapeutic management of Head and neck patients. PMID:25653721

Padhi, Swatishree; Saha, Arka; Kar, Madhabananda; Ghosh, Chinmoy; Adhya, Amit; Baisakh, Manas; Mohapatra, Nachiketa; Venkatesan, Shriram; Hande, Manoor Prakash; Banerjee, Birendranath

2015-01-01

409

Clinico-histopathologic and outcome features of cutaneous infundibular keratinizing acanthoma: a case report and literature review  

PubMed Central

The infundibular keratinizing acanthoma (IKA) is a rare epithelial benign keratin-containing neoplasm of hair follicles. The purpose of this study was to evaluate the defining histopathologic architecture of IKA. A typical IKA consisted of a keratin-filled crypt in the dermis and subcutis that opened to the skin surface. Most of this tumor occurred on the back, neck, head, and the shoulders. Microscopically, the dermal nodules were focally contiguous in both the dermis and subcutis. Furthermore, most histological lesions are consistent with a simple or multiloculated cyst filled with keratin and lined by a wall of stratified squamous epithelium; keratin appears as a concentric lamellar mass, with a keratotic pearly aspect. Histological examination of the cutaneous lesions revealed that the growths were comprised of IKA. IKA of man and dog were compared, and it was concluded that although they are similar in many respects, they are not identical entities. To the best of our knowledge, this is the first report on the prevalence of IKAs among the population of owned dogs in Iran. PMID:24890648

2014-01-01

410

Clinico-histopathologic and outcome features of cutaneous infundibular keratinizing acanthoma: a case report and literature review.  

PubMed

The infundibular keratinizing acanthoma (IKA) is a rare epithelial benign keratin-containing neoplasm of hair follicles. The purpose of this study was to evaluate the defining histopathologic architecture of IKA. A typical IKA consisted of a keratin-filled crypt in the dermis and subcutis that opened to the skin surface. Most of this tumor occurred on the back, neck, head, and the shoulders. Microscopically, the dermal nodules were focally contiguous in both the dermis and subcutis. Furthermore, most histological lesions are consistent with a simple or multiloculated cyst filled with keratin and lined by a wall of stratified squamous epithelium; keratin appears as a concentric lamellar mass, with a keratotic pearly aspect. Histological examination of the cutaneous lesions revealed that the growths were comprised of IKA. IKA of man and dog were compared, and it was concluded that although they are similar in many respects, they are not identical entities. To the best of our knowledge, this is the first report on the prevalence of IKAs among the population of owned dogs in Iran. PMID:24890648

Tavasoly, Abbas; Gholami, Hossein; Rostami, Amir; Anissian, Ali; Touni, Seyed Rashid; Khaleghian, Pooyan; Mokarizadeh, Aram; Javanbakht, Javad; Nasoori, Alireza

2014-01-01

411

Hydroxyurea in sickle cell disease—A study of clinico-pharmacological efficacy in the Indian haplotype  

Microsoft Academic Search

There is clinical variability in the presentation of sickle cell disease among Indians. Vaso-occlusive crisis is common among non-tribal patients. Hydroxyurea, induces fetal hemoglobin (HbF) synthesis and reduces the clinical severity of sickle cell disease but individual patients have a variable response. This study was undertaken to investigate the efficacy and safety of hydroxyurea in Indians with severe manifestations where

Khushnooma Italia; Dipty Jain; Sushma Gattani; Farah Jijina; Anita Nadkarni; Pratibha Sawant; Sona Nair; Dipika Mohanty; Kanjaksha Ghosh; Roshan Colah

2009-01-01

412

A clinico-epidemiologic study of 892 patients with burn injuries at a tertiary care hospital in Punjab, India  

PubMed Central

Aim: To analyze the causes, demographic and socio-cultural aspects, and the magnitude of burn injuries prospectively and to evaluate the outcome of treatment of patients admitted to burns ICU of tertiary care hospital. Materials and Methods: A total of 892 burn patients admitted over a period of 6 years from January 2002 to December 2007 at tertiary care hospital in Punjab, India, were analyzed. Results: 54% patients were males. A majority of the patients, 704(79%), were in the age group of 15-45 years. Six hundred and thirty-four patients (72%) sustained flame burns, while 17% and 7% sustained electrical and scald burns, respectively. A total of 470(53%) patients sustained major two to three degree flame burns involving more than 45% of total body surface area (TBSA). The mortality rate was 40%, i.e. 357 patients died of burns and its related problems, in our study. Six hundred and thirty-nine patients (72%) sustained burns in closed space of which 331 patients (52%) sustained burns in kitchen. Seven hundred and seventy-nine patients sustained accidental burns. Burn victims were mainly Hindus and Sikhs. The mean hospital stay varied depending upon the percentage of burns. On an average, a patient with > 45% TBSA burns received 15 whole blood transfusions. Split skin grafting was done in 416 patients. Most common complication encountered during their hospital stay was wound infection which was seen in 671 patients, followed by ARDS in 221 patients. The most common organisms causing wound infection were Pseudomonas and Acinetobacter. Conclusion: Developing country like India need an aggressive public education program so that people become more literate about various etiological factors causing burns and means of preventing them. Also needed are burn care hospitals which are easily accessible and affordable. PMID:21633560

Gupta, Ashok K; Uppal, Sanjeev; Garg, Ramneesh; Gupta, Ashish; Pal, Ranabir

2011-01-01

413

Survivin expression in ovarian cancer and its correlation with clinico-pathological, surgical and apoptosis-related parameters  

PubMed Central

We investigated the association of survivin expression with prognosis and other apoptosis-related biological factors in 110 primary ovarian cancer patients admitted to the Division of Gynecologic Oncology, Catholic University of Rome. Immunohistochemistry was performed on formalin-fixed, paraffin-embedded sections by using polyclonal antibody ab469 for survivin, and mouse monoclonal antibodies (clone 124 and DO-7), for bcl-2 and p53, respectively. Cytoplasmic survivin immunoreaction was observed in 84.5% cases, while nuclear survivin immunostaining was observed in 29.1% cases. We failed to find any relationship between cytoplasmic survivin positivity rate and any of the parameters examined. Serous tumours showed a lower percentage of nuclear survivin positivity with respect to other histotypes (20.5 vs 48.6%, respectively; P-value=0.004). The percentage of nuclear survivin positivity was higher in cases subjected to primary tumour cytoreduction (43.5%), with respect to patients subjected to exploratory laparotomy (20%) (P=0.024). Bcl-2 and p53 were, respectively, expressed in 27.3 and 60.0% of the cases and their expression was not correlated with survivin status. During the follow-up period, progression and death of disease were observed in 68 (61.8%) and 53 (48.2%) cases, respectively. There was no difference in time to progression and overall survival according to survivin status in ovarian cancer patients. In conclusion, in our experience, the immunohistochemical assessment of survivin status does not seem to be helpful in the prognostic characterisation of ovarian cancer. A more in depth investigation of the complex physiology of divergent survivin variants is needed in order to clarify the biological and the clinical role of differentially located survivin isoforms. PMID:15655541

Ferrandina, G; Legge, F; Martinelli, E; Ranelletti, F O; Zannoni, G F; Lauriola, L; Gessi, M; Gallotta, V; Scambia, G

2005-01-01

414

Clinico-pathological studies on the effect of different anti-neoplastic chemotherapy regimens on transmissible venereal tumours in dogs  

Microsoft Academic Search

Thirty-two dogs affected with transmissible veneral tumour (TVT) were divided into three treatment groups. In group I vincristine sulphate at 0.025 mg\\/kg body weight, in group II vinblastine sulphate at 0.150 mg\\/kg body weight, and in group III vinblastine sulphate at 0.100 mg\\/kg body weight plus methotrexate at 0.35 mg\\/kg body weight were given intravenously at weekly intervals. Biopsies were

J. Singh; J. S. Rana; N. Sood; G. R. Pangawkar; P. P. Gupta

1996-01-01

415

Analysis of the clinico-hematological relevance of the breakpoint location within M-BCR in chronic myeloid leukemia.  

PubMed

The Philadelphia chromosome (Ph) derives from the balanced translocation between chromosomes 9 and 22. This chromosomal translocation results in the fusion between the 5' part of the BCR gene, normally located on chromosome 22, and the 3' part of the ABL gene on chromosome 9 giving origin to a BCR-ABL fusion gene which is transcribed and then translated into a hybrid protein. In general, three breakpoint cluster regions in the BCR gene have been described: major (M-BCR), minor (m-BCR) and micro (?-BCR). Three main variants of the BCR-ABL gene have been described depending on the length of the sequence of the BCR gene included that encode for the P190, P210, P230 proteins. Most patients (95 %) were found to have P210 protein that resulted from rearrangement in the M-BCR region in the BCR gene and thus gives rise to b2a2 or b3a2 variants. The incidence of one or other rearrangement in chronic myeloid leukemia (CML) patients varies in different reported series. These two variants are associated with distinct clinical types of human leukemias. In this study, we report the frequencies of M-BCR-ABL fusion transcripts in 44 CML patients and we review the data on the correlations between the type of M-BCR/ABL variant and the corresponding sex, age and biological features. Forty-four untreated chronic phase CML patients were studied. The type of BCR-ABL fusion transcripts was determined by reverse transcriptase polymerase chain reaction (RT-PCR). More than half of them showed b3a2 fusion transcript (64 %), while (36 %) showed b2a2 transcript. No patients coexpressed b3a2/b2a2. Correlation between biological data demonstrated that: (a) M-BCR rearrangements were not associated with the sex of the patients. (b) Patients with b3a2 rearrangements were older than patients with b2a2 transcripts. (c) M-BCR rearrangements were influenced neither by the white blood count (WBC) nor with hemoglobin levels. However, platelet level is more elevated in patients with b3a2 transcript (681.2/L vs. 207/L; P = 0.001). In conclusion, we observed significant correlations between age, platelet level and M-BCR-ABL transcript, these observations deserve further investigations. PMID:23269583

Bennour, Ayda; Ouahchi, Ines; Achour, Bechir; Zaier, Monia; Youssef, Yosra Ben; Khelif, Abderrahim; Saad, Ali; Sennana, Halima

2013-03-01

416

Assessment of clinico-immunological profile of newly diagnosed HIV patients presenting to a teaching hospital of eastern India  

PubMed Central

Background & objectives: Newly diagnosed HIV patients may be asymptomatic or present with a wide range of symptoms related to opportunistic infections, acute seroconversion illness or other medical illnesses. This study was designed to evaluate the socio-demographic parameters, spectrum of the presenting clinical conditions and concurrent immunological status of newly diagnosed HIV patients and document the WHO clinical stages at the time of HIV diagnosis. Methods: This cross-sectional, observational study was undertaken over a 12 month period at a tertiary referral hospital in eastern India. Three hundred sixty consecutive newly diagnosed HIV patients were selected for the study from the HIV clinic and medicine wards of this hospital. Demographic and clinical data and relevant laboratory investigations of the patients were recorded and analyzed. Results: Mean age of patients was 36.38 ± 10.62 yr, while 63.89 per cent were males. The main mode of transmission of HIV for males and females were unprotected exposure to commercial sex (139, 60.44%) and intercourse with HIV seropositive spouses (89, 68.46%), respectively. Fever (104, 28.89%), weight loss (103, 28.61%) and generalized weakness (80, 22.22%) were the predominant symptoms. Overall mean CD4 count was 176.04 ± 163.49 cells/?l (males 142.19 ± 139.33 cells/?l; females 235.92 ± 185.11 cells/?l). Overall, 224 opportunistic infections were documented in 160 patients, opportunistic diarrhoea (44, 12.22%) and pulmonary tuberculosis (39, 10.83%) being the commonest. There were 83 and 133 patients in WHO clinical stages 3 and 4, respectively; 291 (80.83%) patients were eligible for initiation of first-line antiretrovirals at presentation. Interpretation & conclusions: Advanced immunodeficiency and burden of opportunistic infections characterize newly diagnosed HIV patients in eastern India. The physicians should keep in mind that these patients may have more than one clinical condition at presentation. PMID:25109725

Bishnu, Saptarshi; Bandyopadhyay, Dipanjan; Samui, Samiran; Das, Indrani; Mondal, Pradip; Ghosh, Pramit; Roy, Deeptarka; Manna, Sukanta

2014-01-01

417

Hydroxyurea in sickle cell disease--a study of clinico-pharmacological efficacy in the Indian haplotype.  

PubMed

There is clinical variability in the presentation of sickle cell disease among Indians. Vaso-occlusive crisis is common among non-tribal patients. Hydroxyurea, induces fetal hemoglobin (HbF) synthesis and reduces the clinical severity of sickle cell disease but individual patients have a variable response. This study was undertaken to investigate the efficacy and safety of hydroxyurea in Indians with severe manifestations where the beta(s) gene is linked to the Arab-Indian haplotype and is associated with higher HbF levels. Seventy-seven patients (29 adult sickle homozygous, 25 pediatric sickle homozygous, 23 adult sickle beta-thalassemia) selected for hydroxyurea therapy were evaluated for clinical, hematological, biochemical and genetic parameters and were followed for 24 months. Ninety-eight point seven percent of the sickle chromosomes were linked to the Arab-Indian haplotype, 27% of patients had associated alpha thalassemia and 65% were Xmn I +/+. Seventy-eight percent of the patients had no further crises after starting hydroxyurea. This effect was accompanied by a significant increase in HbF (p<0.001), but this increase was variable in individual cases. There was also an increase in gamma gene mRNA expression in the few cases so studied. Hemoglobin levels increased significantly (p<0.001) resulting in the cessation of blood transfusions. Leucopoenia was observed in one patient. Hydroxyurea was effective in reducing the clinical severity in Indian patients who initially had higher HbF levels and the presence of ameliorating factors, such as alpha-thalassemia and the Xmn I polymorphism. Hydroxyurea therapy with careful monitoring can thus change the quality of life of Indians with sickle cell disease. PMID:18954999

Italia, Khushnooma; Jain, Dipty; Gattani, Sushma; Jijina, Farah; Nadkarni, Anita; Sawant, Pratibha; Nair, Sona; Mohanty, Dipika; Ghosh, Kanjaksha; Colah, Roshan

2009-01-01

418

Evaluation of specifically designed implants placed in the low-density jaw bones: A clinico-radiographical study  

PubMed Central

Aim: In the less dense bone, it is difficult to obtain implant anchorage. The present study was undertaken to determine the survival rate of Maestro™ implants placed in d3 and d4 bones. Materials and Methods: Fourteen patients (10 males and 4 females) were selected for the study and implants were evaluated for posttreatment changes in at 3, 6, 9 and 12 months from implant placement. The implant probing depth and mobility were recorded 3 and 6 months after prosthesis placement. Also, peri-implant bone level was assessed at the baseline and 12 months postoperatively, followed by a statistical analysis. Results: The mean plaque and gingival indices showed a reduction at repeated intervals. The mean sulcular bleeding showed a slight reduction which was statistically significant. An overall mean bone loss was observed after 12 months follow-up, which was statistically not significant. The overall survival rate of implants was reported as 92.3%. Conclusion: The specific implant used in the study is advantageous in the soft bone condition. Clinical Significance: Although, there is a great evidence of implant failure in compromised jaw quality, the newer designs and approaches suggest that the poor quality is not a contraindication. PMID:25684910

Munjal, Sumit; Munjal, Seema; Hazari, Puja; Mahajan, Harsh; Munjal, Akshay; Mehta, D. S.

2015-01-01

419

[The clinico-echocardiographic characteristics of heart involvement in seronegative spondylarthritis (Reiter's disease, Bechterew's disease and psoriatic arthritis)].  

PubMed

As many as 136 patients (76 with Bechterew's disease, 40 with Reiter's disease and 20 with psoriatic arthritic) and 35 practically healthy persons were examined by echocardiography combined with electro-, phonocardiographic and by clinical, x-ray and laboratory methods. 62 patients were examined over time (within a period from 1 to 4 years). Echocardiography was used to study in detail the central and intracardiac hemodynamics, the status of the valvular apparatus of the heart and of the aorta. The different clinical characteristics of the disease were established to make a concrete contribution to the development of cardial pathology. The disease duration is the most significant characteristics. A long-term prospective follow-up coupled with echocardiographic examinations made over time enabled one to specify the structure of heart damage in patients suffering from Bechterew's disease, Reiter's disease and psoriatic arthritis depending on the hypothetic nature of the damage. PMID:1887416

Korshunov, N I; Dormidontov, E N; Dzhurko, T Iu

1991-01-01

420

Physico-chemical and clinico-immunologic studies on the allergenic significance of Aspergillus tamarii, a common airborne fungus.  

PubMed

Aspergillus-derived inhalant allergens play an important role in the etiology of allergic respiratory diseases. In the present study, we investigated the allergenic potential of Aspergillus tamarii, quantified its airborne content, identified its major/minor allergens, evaluated heterogeneity of patients' IgE response to its allergens and cross-reactivity of its allergens with other Aspergillus allergens. Skin prick tests with A tamarii extract were performed on 300 patients of bronchial asthma/allergic rhinitis and 20 healthy volunteers. Sixty-six patients (22%) elicited positive cutaneous reactions to A tamarii extract. Only one of the 20 non-allergic healthy volunteer showed a mild positive cutaneous reaction. Allergen-specific IgE levels increased with increase in patients' cutaneous response (0% in negative to 100% in 3+/4+). The skin positivity and allergen-specific IgE levels were significantly higher in patients compared to healthy volunteers (P>0.05). However, no differences were found for these two parameters among patients of bronchial asthma, allergic rhinitis and bronchial asthma with allergic rhinitis. The airborne A tamarii allergen content was highest in February and October. A tamarii extract revealed at least 22 proteins (13.3-120 kDa). Seventeen of these proteins bound patients' IgE with six being major allergens (13.3, 23, 25, 34, 39.5, 43 kDa). Three major allergens (13.3, 34, 43 kDa) were found to cross-react with A flavus and one (34 kDa) with A niger. Our results revealed that A tamarii allergen(s) are present in the air, which might serve as important inhalant allergens in IgE-mediated allergic respiratory diseases. PMID:20667623

Vermani, Maansi; Vijayan, Vannan K; Menon, Balakrishnan; Kausar, Mohd A; Agarwal, Mahendra K

2011-03-01

421

PA01.06. Clinico comparative study of shodhan purvak shaman & shaman chikitsa in management of aamvata  

PubMed Central

Purpose: To compare the effect of shodhan purvak shaman & shaman chikitsa in management of aamvata. Method: Above study was planned in two parts conceptual & clinical For clinical part 40 patients having disease aamvata were randomly selected from opd & ipd & were divided in two groups. In shodhan purvak shaman group shodhan basti & shaman vati were given. Which was selected from classic text of ayurveda. In Shaman group only shaman yog vati was administered to the patients. Total duration of treatment in both groups was of 8 weeks. Result: Shodhan purvak shaman therapy has given complete remission in 6 patients, major improvement was found in 9 patients, 4 patients in minor improvement category and one in un improved category. In shaman therapy complete relief was found in 3 patients, major improvement in 12 patients, in minor improved category there were 5 patients no patient was found in unimproved category. Conclusion: The results thus obtained were subjected to analytical statistical techniques to compare both modes of treatments. Critical assessment of total effect of therapies on individual patient reflects that shodhan therapy along with shaman vati was more effective in pacifying the symptoms of disease aamvata & bringing down the level of disease activity also as compared to shaman therapy alone. Mode of action of drug is discussed. No side effects were seen.

Nagpal, Swati

2012-01-01

422

Ocular surface squamous neoplasia – Review of etio-pathogenesis and an update on clinico-pathological diagnosis  

PubMed Central

Ocular surface squamous neoplasia (OSSN) has a varied clinical presentation, the diagnosis of which rests on the histopathological examination of the excised lesion. The term OSSN includes mild dysplasia on one end of the spectrum and invasive squamous cell carcinoma on the other end. This lesion has a multi factorial aetiology with interplay of several factors like exposure to ultraviolet radiation, various chemical carcinogens and viral infections, however role of individual agents is not well understood. With the upsurge of infection with human immunodeficiency virus, a changing trend is seen in the clinical presentation and prognosis of patients of OSSN even in developed countries. Anterior segment optical coherence tomography (OCT) and confocal microscopy, hold promise in in-vivo differentiation of intraepithelial neoplasia from invasive squamous cell carcinoma. Variants of squamous cell carcinoma like Mucoepidermoid carcinoma, spindle cell carcinoma and OSSN associated with HIV infection should be suspected in a case of aggressive clinical presentation of OSSN or with massive and recurrent tumours. Surgery, chemotherapy and immunotherapy are the various treatment modalities which in combination show promising results in aggressive, recurrent and larger tumours. PMID:24227983

Mittal, Ruchi; Rath, Suryasnata; Vemuganti, Geeta Kashyap

2013-01-01

423

Inversor Resonante de Tres Elementos L-LC con Caracteristica Cortocircuitable para Aplicaciones de Calentamiento por Induccion  

NASA Astrophysics Data System (ADS)

Los generadores de calentamiento por induccion son puentes inversores con carga resonante, cuya mision es basicamente crear una corriente sinusoidal de gran amplitud sobre la "bobina de caldeo", que forma parte del tanque resonante. En el interior de esta bobina se introduce la pieza que se desea calentar. EI campo magnetico creado induce corrientes superficiales (corrientes de Foucault) sobre la pieza, que producen su calentamiento. Los tanques resonantes (tambien llamados osciladores) utilizados en la actualidad son el resonante serie y el resonante paralelo. Aunque ya desde hace algun tiempo se vienen construyendo generadores de alta potencia basados en estos dos osciladores, el exito nunca ha. sido completo en ninguno de los dos casos. Tal y como se explica en la introduccion de esta memoria, los puentes inversores utilizados deben operar sobre una carga inductiva (corriente retrasada) para evitar el fenomeno de la recuperacion inversa de sus diodos y la consiguiente ruptura de los transistores. De la restriccion topologica anterior se deduce que el generador paralelo debe conmutar a frecuencias inferiores a la resonancia, y el serie a frecuencias superiores. A esta restriccion topologica hay que unir otra que es exclusiva del calentamiento por induccion: La corriente por la bobina de caldeo debe ser sinusoidal. De no ser asi, resultaria imposible disponer toda la potencia de calentamiento sobre la pieza en el espesor requerido por la aplicacion. Como consecuencia, los inversores no pueden operar por debajo de la frecuencia de resonancia del oscilador, pues en ese caso se amplifican los armonicos de orden superior de la tension/corriente de entrada situados sobre la resonancia, con la consiguiente distorsion de la corriente de salida. La conjuncion de las dos restricciones anteriores obligan al inversor paralelo a funcionar a la frecuencia de resonancia del oscilador. Esto imposibilita un control por variacion de frecuencia, regulandose la potencia desde la seccion de entrada mediante un mayor o menor aporte de corriente al puente. Como consecuencia, la seccion de entrada del paralelo, ya de por si mas voluminosa que lao del serie por el uso de grandes componentes magneticos (bobinas de filtro o de "alisamiento"), result a tambien mas complicada y costosa debido a la necesidad de ser implementada mediante rectificador controlado. Ademas, la regulacion que ofrece el rectificador es pobre, dada su baja frecuencia de conmutacion. En cambio, el circuito serie puede funcionar por encima de la resonancia manteniendo una secuencia de conmutacion sin riesgos de recuperacion inversa y con una corriente de salida practicamente sinusoidal, lo que permite un control de la potencia por variacion de frecuencia. Puesto que la tarea de regulacion se realiza desde el puente inversor, la regulacion resulta mucho mas eficaz y la seccion de entrada se puede implementar mediante un simple rectificador no controlado y un condensador de filtro. (Abstract shortened by UMI.).

Espi Huerta, Jose Miguel

424

Bolet´ in de la Asociaci´ on Matem´ atica Venezolana, Vol. IX, No. 2 (2002) 109 Billares. Modelos con Din´ amicas Ca´ oticas  

Microsoft Academic Search

Resumen Se exponen en forma sencilla las relaciones del modelo de los gases de Boltzmann y su Hip´ otesis Erg´ odica con la moderna Teor´ ia Erg´ odica. Se da una descripci´ on de la formulaci´ on matem´ atica de la Teor´ ia de Billares y sus consecuencias en el modelo de las bolas duras. 1I n troducci´ on En

425

iCons 3E Syllabus (NatSci389H) NatSci 389H (formerly 390IH) Team-oriented Lab Discovery  

E-print Network

energy conversion, energy storage, biomass energy, combinatorial energy design, capturing waste energy in Renewable Energy [iCons 3E] Syllabus Spring 2014 Course Vision This course involves student-driven, team-oriented laboratory projects focused on the interrelated principles of energy generation, conversion, storage

Auerbach, Scott M.

426

First-order equation worksheet Name: Problem 1. A container has the maximum capacity 100 L. Initially, 50 L of salt water (with con-  

E-print Network

also) [This is not our typical problem. Note that the water level is changing with time.] (1) Let QFirst-order equation worksheet Name: Problem 1. A container has the maximum capacity 100 L. Initially, 50 L of salt water (with con- centration 2g/L) is in the container. Then, salt water (with

Oh, Seungly

427

El embarazo en la mujer con enfermedad cardiaca congénita: enfoque para el cardiólogo Congenital heart disease in the pregnant woman: a guide for the cardiologist  

Microsoft Academic Search

La enfermedad cardiaca congénita es la forma más común de alteración estructural cardiaca que afecta a la mujer en edad reproductiva en los países en vía de desarrollo. En estas pacientes el embarazo se asocia con mayor riesgo tanto para la madre como para el feto. Se recomienda la consejería y una evaluación prenatal adecuada, para evaluar los riesgos e

Edgardo Vanegas; Juan K. Urrea

428

40 CFR 180.1213 - Coniothyrium minitans strain CON/M/91-08; exemption from the requirement of a tolerance.  

Code of Federal Regulations, 2012 CFR

...from the requirement of a tolerance. An exemption from the requirement of a tolerance is established for residues of the microbial pesticide Coniothyrium minitans strain CON/M/91- 08 when used in or on all food commodities. [66 FR 16874,...

2012-07-01

429

Synthesis of water-soluble Ag?Se QDs as a novel resonance Rayleigh scattering sensor for highly sensitive and selective ConA detection.  

PubMed

Ag2Se quantum dots (QDs) have attracted a lot of interest due to their potential applications in biosensing and bioimaging. A strategy is presented that involves coupling of selenium powder reduction with the binding of silver ions, and thioglycollic acid (TGA) and glycine as stabilizers to obtain ultrasmall Ag2Se QDs at 85 °C in aqueous solution. This strategy avoids high temperatures, high pressures and organic solvents so that water-soluble 3 nm Ag2Se QDs can be directly obtained. The conjugation of ConA to TGA stabilized Ag2Se QDs by hydrogen bonds leads to the adsorption of ConA to Ag2Se QDs and forms the aggregation and leads to the generation of resonance Rayleigh scattering (RRS) as a readout signal for the sensing events. The reaction mechanism of Ag2Se QD RRS enhancement is studied in this work. The resulting RRS sensor enables the detection of ConA with limit of detection reaching 0.08 ?g mL(-1) concentration in a wide linear range from 0.27 ?g mL(-1) to 35 ?g mL(-1). The recovery of spiked ConA in human serum samples ranges from 94% to 106%. The relative standard deviation (RSD) for eleven replicate detections is 3.6%. Our results correlate many important experimental observations and will fuel the further growth of this field. PMID:24957549

Yan, Shuguang; Zhang, Lichun; Tang, Yurong; Lv, Yi

2014-09-01

430

Este encuentro internacional pretende proponer, a nivel de Europa occidental, un debate sobre cuestiones relacionadas con la arquitectura funeraria y la  

E-print Network

cuestiones relacionadas con la arquitectura funeraria y la gestión de los conjuntos sepulcrales-14 ARQUITECTURAS FUNERARIAS Y MEMORIA: LA GESTIÓN DE LAS NECRÓPOLIS EN EUROPA OCCIDENTAL(SIGLOS X-III a.C.) ARQUITECTURAS FUNERARIAS Y MEMORIA: LA GESTIÓN DE LAS NECRÓPOLIS EN EUROPA OCCIDENTAL (SIGLOS X-III a

Escolano, Francisco

431

Transformacin del campus para el desarrollo de un modelo social integral y su interaccin con el entorno territorial Tabla I. Descripcin de las actuaciones del proyecto  

E-print Network

, promociones entre los estudiantes y presencia activa en los actos de graduación, newsletters, redes sociales yTransformación del campus para el desarrollo de un modelo social integral y su interacción con el colectivo de referencia en los ámbitos de ciencias sociales, de la comunicación y de la biomedicina

Geffner, Hector

432

iCons 2 Renewable Energy [NatSci 290IH (2) aka i2e] Spring 2013 Syllabus i2e Faculty Guides  

E-print Network

1 iCons 2 Renewable Energy [NatSci 290IH (2) aka i2e] ­ Spring 2013 Syllabus i2e Faculty Guides Objectives: Students learn to ... in the context of Renewable Energy problems. 1. ... write effectively Trip: Campus Heating and Power (CHP) Thursday Feb 9: Work on Energy Flow Diagram for UMass Amherst

Auerbach, Scott M.

433

Pure Appl. Chem., Vol. 82, No. 12, pp. 22472279, 2010. doi:10.1351/PAC-CON-10-09-04  

E-print Network

2247 Pure Appl. Chem., Vol. 82, No. 12, pp. 2247­2279, 2010. doi:10.1351/PAC-CON-10-09-04 © 2010 to the trans form once the UV source is removed. Although this thermal re-isomerization is slow, *Pure Appl

Martin, Jan M.L.

434

DESARROLLO DE HABILIDADES COGNITIVAS EN NIÑOS(AS) ORIENTADO EN LA METACOGNICION A TRAVES DE LA INTERACCION CON ROBOTS MOVILES EN AMBIENTES DE REALIDAD VIRTUAL  

Microsoft Academic Search

Resumen: Este trabajo es la presentación de un proceso de investigación que esta orientado en el uso de las herramientas tecnológicas, especialmente en el manejo con robots móviles en ambientes virtuales, para estimular el desarrollo de habilidades cognitivas en los estudiantes desde temprana edad, retroalimentándose en modelos pedagógicos como el Constructivismo, la Heurística y la Metacogniciòn, este último, el espacio

Maria E. Pérez Mantilla; Grupo de Investigación

435

In a complex and all too often tragic world, it is useful to con-sider some comments from a great statesman as he guided his  

E-print Network

In a complex and all too often tragic world, it is useful to con- sider some comments from a great. My youth was also a time of war, of intense global competition, and of terrible weapons of mankind. My generation didn't do too badly. We defeated Communism without a nuclear war. We helped lead

Bieber, Michael

436

Basi di Dati, 20/12/2004, secondo compitino, compito A 1) Si consideri lo schema relazionale R(A,B,C,D,E) con le seguenti DF  

E-print Network

+ =BD. Applico l'algoritmo visto a lezione: BDA+ =BDACE BDC+ =BDCEA BDE+ =BDEAC Quindi le chiavi sono: BDA, BDC, BDE. b) Dire se lo schema è in 3FN, e in ogni caso decomporlo con l'algoritmo di sintesi

Ghelli, Giorgio

437

AC 2011-376: WIRELESS-INTEGRATED EMBEDDED REAL-TIME CON-TROL: A CASE STUDY IN ADOPTING RESOURCES FOR DEVELOP-  

E-print Network

AC 2011-376: WIRELESS-INTEGRATED EMBEDDED REAL-TIME CON- TROL: A CASE STUDY IN ADOPTING RESOURCES of Engineering. cAmerican Society for Engineering Education, 2011 #12;Wireless-Integrated Embedded Real in areas of control and embedded systems that weaves critical aspects of control systems design with real

438

Animaciones en 3D en tiempo real para las clases de ciencias e ingeniería: Ejemplos desarrollados con el módulo de programación VPython  

Microsoft Academic Search

RESUMEN: Se describe el uso del módulo de programación VPython para desarrollar animaciones en 3D por computadora para ilustrar temas de interés para las clases. Mostramos la utilidad del uso de animaciones para reforzar las presentaciones de materias como física y matemática, entre otras. Con tales presentaciones se puede innovar en el desarrollo de las clases de ciencias e ingeniería

Eduardo E. Rodríguez

439

BANDO PER IL RECLUTAMENTO DI UN RICERCATORE CON RAPPORTO DI LAVORO A TEMPO DETERMINATO COFINANZIATO DALLA REGIONE LAZIO -SAPIENZA UNIVERSIT DI ROMA -  

E-print Network

nella seduta del 20.07.2010 Vista la convenzione Sapienza ­ Università della Tuscia approvata con effetti dell'art. 3 della Convenzione Sapienza ­ Università della Tuscia, è indetta una procedura di, tuttavia, sulla base della convenzione tra Sapienza e l'Università della Tuscia, e del progetto citato

Guidoni, Leonardo

440

Geometria III, Problemas 5 Segundo semestre, 2009/10. (R) es el plano proyectivo con la estructura diferencial estudiada en clase.  

E-print Network

circunferencia con centro (t, t2 ) y radio t. Halle (t0)(f). (d) Si C0 es la circunferencia unidad centrada en el origen, escriba la matriz de dC0 en las bases de vectores coordenados de la carta global de M y la

Guijarro, Luis

441

Geometria III, Problemas 5 Primer semestre, 2010/11. (R) es el plano proyectivo con la estructura diferencial estudiada en clase.  

E-print Network

circunferencia con centro (t, t2 ) y radio t. Halle (t0)(f). (d) Si C0 es la circunferencia unidad centrada en el origen, escriba la matriz de dC0 en las bases de vectores coordenados de la carta global de M y la

Guijarro, Luis

442

Decreto n. 3625 IL RETTORE VISTA la nota e-mail datata 26 aprile 2011 con la quale il Prof.Giuseppe Visaggio,  

E-print Network

.Giuseppe Visaggio, Presidente del Daisy Net Scarl, ha trasmesso la convocazione dell'Assemblea dei Soci prevista per Competenza ICT - SUD". Articolo 1 -- DENOMINAZIONE I soci partecipanti a DAISY-Net forni- ranno ciascuno alla svolgimento delle attività previste dal presente statuto. DAISY-Net può ope- rare anche con terzi. Art, 13

Malerba, Donato

443

REAL-TIME WORKSHOP EN LA INVESTIGACIÓN : IMPLEMENTACIÓN DE DIVERSOS CONTROLADORES SOBRE UN SISTEMA SISO NO LINEAL Y SOBRE UN ROBOT MÓVIL CON VISIÓN ARTIFICIAL  

Microsoft Academic Search

Resumen En este artículo se muestra el trabajo que se está realizando en nuestra universidad en relación a Real-Time Workshop. Con el objetivo de disponer de un entorno que permita completar el proceso de análisis, diseño y implementación, se han desarrollado drivers específicos para tarjetas de adquisición de datos así como para permitir el acceso al puerto de comunicación serie

A. Oller; C. Pous; S. Esteva; J. Ll

444

arXiv:submit/0083985[cond-mat.supr-con]29Jul2010 Metastability in a nano-bridge based hysteretic DC-SQUID embedded in  

E-print Network

arXiv:submit/0083985[cond-mat.supr-con]29Jul2010 Metastability in a nano-bridge based hysteretic DC-SQUID study the metastable response of a highly hysteretic DC-SQUID made of a Niobium loop interrupted by two nano-bridges. We excite the SQUID with an alternating current and with direct magnetic flux, and find

Buks, Eyal

445

arXiv:submit/0276414[cond-mat.supr-con]4Jul2011 Fabrication of Nb/Al(AlOx)/Nb DC SQUID by focused ion beam sculpturing  

E-print Network

arXiv:submit/0276414[cond-mat.supr-con]4Jul2011 Fabrication of Nb/Al(AlOx)/Nb DC SQUID by focused interference devices (DC SQUID) were fabricated by three dimensional etching using fo- cused ion beam. Hysteretic and non-hysteretic DC SQUID with critical current ranging from 25 to 1100 µA were fabricated

Buks, Eyal

446

Synthesis, growth, structural, spectral, thermal, chemical etching, linear and nonlinear optical and mechanical studies of an organic single crystal 4-chloro 4-nitrostilbene (CONS): a potential NLO material.  

PubMed

4-Chloro 4-nitrostilbene (CONS) a new organic nonlinear optical material has been synthesized. Employing slow evaporation method, good optical quality single crystals (dimensions up to 6×2×3 mm(3)) have been grown using ethyl methyl ketone (EMK) as a solvent. The grown crystals have been subjected to various characterizations such as single crystal X-ray diffraction, powder XRD, Fourier Transform Infrared spectroscopy (FTIR), proton NMR, solid UV absorption, SHG studies. Single crystal X-ray diffraction reveals that the crystal system belongs to monoclinic with noncentrosymmetric space group P21. The UV-Vis absorption spectrum has been recorded and found that the cut off wavelength is 380 nm. Functional groups and the structure of the title compound have been confirmed by FTIR and (1)H NMR spectroscopic analyses respectively. Molecular mass of the CONS confirmed by the high resolution mass spectral analysis .The thermal behavior of the grown crystal has been studied by TG/DTA analysis and it shows the melting point is at 188.66 °C. Dislocations and growth pattern present in the grown crystal revealed by the etching study. The mechanical strength of the CONS crystal has been studied by Vicker's hardness measurement. The SHG efficiency of the grown crystal has been determined by Kurtz and Perry powder test which revealed that the CONS crystal (327 mV) has 15 times greater efficiency than that of KDP (21.7 mV). PMID:23624038

Dinakaran, Paul M; Kalainathan, S

2013-07-01

447

A TU PER TU CON L'ARTISTA Al Mart di Rovereto si aprono le selezioni per due volontari in qualit di  

E-print Network

A TU PER TU CON L'ARTISTA Al Mart di Rovereto si aprono le selezioni per due volontari in qualità di assistente d'artista. Richiesta la conoscenza della lingua spagnola. Il Mart offre la possibilità curriculum vitae aggiornato, dati personali e contatti telefonici e postali, a: - Indirizzo mail volontari@mart

448

IL DIPARTIMENTO DI ................ DELL'UNIVERSITA' DEGLI STUDI DI TORINO (di seguito chiamato DIPARTIMENTO), con sede legale in Torino, .........., C.F.: 80088230018, rappresentato  

E-print Network

Dipartimento in data ................ E ............................... (di seguito chiamato Ente), con sede. Art. 3 - Durata Il presente accordo entrerà in vigore alla data di stipula del presente atto ed avrà'uso. Tutte le spese derivanti dalla stipula della presente convenzione, comprese quelle di registrazione

Sproston, Jeremy

449

THE TOROIDAL EMBEDDING ARISING FROM AN IRRATIONAL FAN ABSTRACT. A toroidal embedding is defined which does not assume the fan con-  

E-print Network

THE TOROIDAL EMBEDDING ARISING FROM AN IRRATIONAL FAN T. J. FORD ABSTRACT. A toroidal embedding is defined which does not assume the fan con- sists of rational cones. For a rational fan, the toroidal embedding is the usual toric variety. If the fan is not rational, the toroidal embedding is in general

Ford, Timothy J.

450

Analysis of cancer risk and BRCA1 and BRCA2 mutation prevalence in the kConFab familial breast cancer resource  

PubMed Central

Introduction The Kathleen Cuningham Foundation Consortium for Research into Familial Breast Cancer (kConFab) is a multidisciplinary, collaborative framework for the investigation of familial breast cancer. Based in Australia, the primary aim of kConFab is to facilitate high-quality research by amassing a large and comprehensive resource of epidemiological and clinical data with biospecimens from individuals at high risk of breast and/or ovarian cancer, and from their close relatives. Methods Epidemiological, family history and lifestyle data, as well as biospecimens, are collected from multiple-case breast cancer families ascertained through family cancer clinics in Australia and New Zealand. We used the Tyrer-Cuzick algorithms to assess the prospective risk of breast cancer in women in the kConFab cohort who were unaffected with breast cancer at the time of enrolment in the study. Results Of kConFab's first 822 families, 518 families had multiple cases of female breast cancer alone, 239 had cases of female breast and ovarian cancer, 37 had cases of female and male breast cancer, and 14 had both ovarian cancer as well as male and female breast cancer. Data are currently held for 11,422 people and germline DNAs for 7,389. Among the 812 families with at least one germline sample collected, the mean number of germline DNA samples collected per family is nine. Of the 747 families that have undergone some form of mutation screening, 229 (31%) carry a pathogenic or splice-site mutation in BRCA1 or BRCA2. Germline DNAs and data are stored from 773 proven carriers of BRCA1 or BRCA1 mutations. kConFab's fresh tissue bank includes 253 specimens of breast or ovarian tissue – both normal and malignant – including 126 from carriers of BRCA1 or BRCA2 mutations. Conclusion These kConFab resources are available to researchers anywhere in the world, who may apply to kConFab for biospecimens and data for use in ethically approved, peer-reviewed projects. A high calculated risk from the Tyrer-Cuzick algorithms correlated closely with the subsequent occurrence of breast cancer in BRCA1 and BRCA2 mutation positive families, but this was less evident in families in which no pathogenic BRCA1 or BRCA2 mutation has been detected. PMID:16507150

Mann, Graham J; Thorne, Heather; Balleine, Rosemary L; Butow, Phyllis N; Clarke, Christine L; Edkins, Edward; Evans, Gerda M; Fereday, Sián; Haan, Eric; Gattas, Michael; Giles, Graham G; Goldblatt, Jack; Hopper, John L; Kirk, Judy; Leary, Jennifer A; Lindeman, Geoffrey; Niedermayr, Eveline; Phillips, Kelly-Anne; Picken, Sandra; Pupo, Gulietta M; Saunders, Christobel; Scott, Clare L; Spurdle, Amanda B; Suthers, Graeme; Tucker, Kathy; Chenevix-Trench, Georgia

2006-01-01

451

Air Traffic Management Technology Demonstration-1 Concept of Operations (ATD-1 ConOps), Version 2.0  

NASA Technical Reports Server (NTRS)

This document is an update to the operations and procedures envisioned for NASA s Air Traffic Management (ATM) Technology Demonstration #1 (ATD-1). The ATD-1 Concept of Operations (ConOps) integrates three NASA technologies to achieve high throughput, fuel-efficient arrival operations into busy terminal airspace. They are Traffic Management Advisor with Terminal Metering (TMA-TM) for precise time-based schedules to the runway and points within the terminal area, Controller-Managed Spacing (CMS) decision support tools for terminal controllers to better manage aircraft delay using speed control, and Flight deck Interval Management (FIM) avionics and flight crew procedures to conduct airborne spacing operations. The ATD-1 concept provides de-conflicted and efficient operations of multiple arrival streams of aircraft, passing through multiple merge points, from top-of-descent (TOD) to the Final Approach Fix. These arrival streams are Optimized Profile Descents (OPDs) from en route altitude to the runway, using primarily speed control to maintain separation and schedule. The ATD-1 project is currently addressing the challenges of integrating the three technologies, and their implantation into an operational environment. The ATD-1 goals include increasing the throughput of high-density airports, reducing controller workload, increasing efficiency of arrival operations and the frequency of trajectory-based operations, and promoting aircraft ADS-B equipage.

Baxley, Brian T.; Johnson, William C.; Swenson, Harry N.; Robinson, John E.; Prevot, Tom; Callantine, Todd J.; Scardina, John; Greene, Michael

2013-01-01

452

Evaluation of GO_CONS_GCF_2_TIM and GOCO01S Geopotential Models in Venezuela and Caribbean Region  

NASA Astrophysics Data System (ADS)

This paper shows two maps of the magnitude of the surface gravity vector (MSGV) of Venezuela and Caribbean region at 1:500.000 scale in the geographic window between the 0-20 north latitude and 74-58 western longitude (Fig. 1 and Fig. 2), that were generated from GOCE gravity gradients data provided by the European Space Agency (ESA). The maps that are showed come from the combined global gravity field model GOCO01s [GOCO Consortium., 2010] and from the satellite-only global gravity field model GO_CONS_GCF_2_TIM [Pail et al., 2010], both of 224 degree. The DEMs used for the evaluation of the MSGV are: Etopo2v2 [NGDC., 2006] and Etopo1 [Amante and Eakins, 2009] respectively. The data processing was done using: Shm2func [ICGEM., 2007]; Goce User Toolbox [ESA., 2009]; Gravsoft package [Tscherning et al., 1992] and Oasis Montaj (Geosoft). This research shows a review of observed gravity in the main geological provinces of the Venezuela and Caribbean region geography, revealing gravitational features important of the geological structures that are in Venezuelan and Caribbean subsurface.

Orihuela, N. D.; Garcia, A. D.; Tabare, T.; Scientific Team Of Venezuelan; Caribbean Crustal Study From Satellital Data

2010-12-01

453

Special funding schemes for innovative medical devices in French hospitals: the pros and cons of two different approaches.  

PubMed

Financing innovative medical devices is an important challenge for national health policy makers, and a crucial issue for hospitals. However, when innovative medical devices are launched on the European market there is generally little clinical evidence regarding both efficacy and safety, both because of the flaws in the European system for regulating such devices, and because they are at an early stage of development. To manage the uncertainty surrounding the reimbursement of innovation, several European countries have set up temporary funding schemes to generate evidence about the effectiveness of devices. This article explores two different French approaches to funding innovative in-hospital devices and collecting supplementary data: the coverage with evidence development (CED) scheme introduced under Article L. 165-1-1 of the French Social Security Code; and national programs for hospital-based research. We discuss pros and cons of both approaches in the light of CED policies in Germany and the UK. The CED policies for devices share common limitations. Thus, transparency of CED processes should be enhanced and decisions need to be made in a timely way. Finally, we think that closer collaboration between manufacturers, health authorities and hospitals is essential to make CED policies more operational. PMID:24794738

Martelli, Nicolas; van den Brink, Hélène

2014-07-01

454

Status and Progress of a Fault Current Limiting Hts Cable to BE Installed in the con EDISON Grid  

NASA Astrophysics Data System (ADS)

In the last decade, significant advances in the performance of second generation (2G) high temperature superconducting wire have made it suitable for commercially viable applications such as electric power cables and fault current limiters. Currently, the U.S. Department of Homeland Security is co-funding the design, development and demonstration of an inherently fault current limiting HTS cable under the Hydra project with American Superconductor and Consolidated Edison. The cable will be approximately 300 m long and is being designed to carry 96 MVA at a distribution level voltage of 13.8 kV. The underground cable will be installed and energized in New York City. The project is led by American Superconductor teamed with Con Edison, Ultera (Southwire and nkt cables joint venture), and Air Liquide. This paper describes the general goals, design criteria, status and progress of the project. Fault current limiting has already been demonstrated in 3 m prototype cables, and test results on a 25 m three-phase cable will be presented. An overview of the concept of a fault current limiting cable and the system advantages of this unique type of cable will be described.

Maguire, J.; Folts, D.; Yuan, J.; Henderson, N.; Lindsay, D.; Knoll, D.; Rey, C.; Duckworth, R.; Gouge, M.; Wolff, Z.; Kurtz, S.

2010-04-01

455

SCUOLA DI ARCHITETTURA E DESIGN.....................................................................................................................2 ARCHITETTURA.............................................................................................  

E-print Network

...........................................................................................................................4 SCUOLA DI MEDICINA INTERNA CLINICO ....................................................10 SCIENZA E TECNOLOGIA DEI MATERIALI

Genova, Università degli Studi di

456

Entrevista con Vicente Leñero  

E-print Network

ingeniería, y yo era bueno para las matemáticas, pero andando el tiempo mis inquietudes eran siempre escribir, ¿no? Pero no pensé que para escribir alguien se pudiera dedicar a eso. En los años cuarenta, cincuenta eso no... no parecía ser un futuro muy... halagüeño. Enton ces yo estudié ingeniería. Finalmente terminé la carrera de ingeniero, pero en el ínterin le dediqué una buena parte al estudio de... yo quería escribir, siempre me costó mucho trabajo, aún todavía Stuart A. Day 19 me cuesta trabajo...

Day, Stuart A.

2004-01-01

457

Circumcision: Pros and cons  

PubMed Central

Circumcision is possibly the most frequently performed elective surgical procedure in men. It can simply be described as the excision of the preputium. There have been several studies about the association between circumcision and urinary tract infections (UTI). Many studies have demonstrated that the frequency of UTI increase in uncircumcised males, especially in the first year of life. This review discusses the embryology of the preputium, epidemiology, indications, complications and benefits of circumcision, as well as operation and anesthesiology techniques. It especially examines the association between UTI and circumcision and the importance of circumcision in congenital urinary system anomalies. In addition, this review examines the associations between circumcision and sexually transmitted diseases, including HIV, and the protective role of circumcision on penile cancer. PMID:20535279

Burgu, Berk; Aydogdu, Ozgu; Tangal, Semih; Soygur, Tarkan

2010-01-01

458

Filtro con capacidades conmutadas  

Microsoft Academic Search

Resumen: El ruido urbano es un factor de contaminación ambiental que puede p rovocar daños más o menos graves, permanentes o no , sobre e l sistema a uditivo h umano. Los parámetros que permiten estimar el nivel de ruido presente en un determinado ambiente, y en consecuencia el nivel de contaminación ambiental y el posible perjuicio que ese nivel

Daniel Crepaldo; María Isabel Schiavon

2000-01-01

459

IDENTIFICACIÓN CON LOS PERSONAJES  

Microsoft Academic Search

The identification with the characters is a mechanism that permits the audience experience from inside the narration, as a consequence of an empathe- tic reaction toward the protagonist. In the present arti- cle two empirical studies are included in which the identification with the characters is analyzed in rela- tion with media entertainment, particularly, with refe- rence to reception and

Juan José Igartua

460

Neo-Conned University  

ERIC Educational Resources Information Center

Censorship, says Australian political theorist John Keane (1991), can "echo within us, take up residence within ourselves, spying on us, a private amanuensis who reminds us never to go too far... It makes us zip our lips, tremble and think twice" (p. 39). It can also make us sick. The author states that this is her argument here: that,…

Jones, Andee

2014-01-01

461

EthicsConRep  

Cancer.gov

The authors also gratefully acknowledge the copy editing assistance of Leslie Alter, MPH and Steve Brown. The Ethical Force Program’s initiative on patient-centered communication is funded in part by the American Medical Association Foundation, The California Endowment, the Commonwealth Fund and the Connecticut Health Foundation.

462

urban ConAgraculture  

Microsoft Academic Search

Current pressures in today’s world caused me to investigate strategies of change in the organization of society to promote a more effi cient existence. Globalization, a movement characterized by the dissemination of economies, ethnicities, media, ideas, technologies, and production; has become today’s reality. The shift from imperialism to globalism has caused a decline in the power and importance of nation

Dale J Luebbert

2009-01-01

463

Adelante con animo  

E-print Network

A proposition of this thesis is that architecture is capable of conveying a sense of animation, movement and energy. These are elusive properties. Their perception perhaps emerges from the building's form or articulation ...

McCullough Maker, Kathleen Grace

1992-01-01

464

I1 piano regolatore di iina citt di circa 50.000 abitanti, in una zona pianeggiante di nuova espansione che fronteggia il mare e confina con una zona a verde pubblico, prevista una  

E-print Network

I1 piano regolatore di iina città di circa 50.000 abitanti, in una zona pianeggiante di nuova piano di recupero di un ambito urbano ricadente in un centro storico, con una rilevante presenza di candidato illustrerà la normativa di riferimento per la redazione del piano di recupero con particolare

Di Pillo, Gianni

465

An inevitable wave of prescription drug monitoring programs in the context of prescription opioids: pros, cons and tensions  

PubMed Central

Background In an effort to control non-medical use and/or medical abuse of prescription drugs, particularly prescription opioids, electronic prescription drug monitoring programs (PDMP) have been introduced in North-American countries, Australia and some parts of Europe. Paradoxically, there are simultaneous pressures to increase opioid prescribing for the benefit of individual patients and to reduce it for the sake of public health, and this pressure warrants a delicate balance of appropriate therapeutic uses of these drugs with the risk of developing dependence. This article discusses pros and cons of PDMP in reducing diversion of prescription opioids, without hampering access to those medications for those with genuine needs, and highlights tensions around PDMP implementation. Discussion PDMPs may help alleviate diversion, over-prescription and fraudulent prescribing/dispensing; prompt drug treatment referrals; avoid awkward drug urine test; and inform spatial changes in prescribing practices and help designing tailored interventions. Fear of legal retribution, privacy and data security, potential confusion about addiction and pseudo-addiction, and potential undue pressure of detecting misuse/diversion - are the major problems. There are tensions about unintended consequence of excessive regulatory enforcements, corresponding collateral damages particularly about inadequate prescribing for patients with genuine needs, and mandatory consultation requirements of PDMP. Summary In this era of information technology PDMP is likely to flourish and remain with us for a long time. A clear standard of practice against which physicians’ care will be judged may expedite the utilisation of PDMP. In addition, adequate training on addiction and pain management along with public awareness, point-of-supply data entry from pharmacy, point-of-care real-time access to data, increasing access to addiction treatment and appropriate regulatory enforcement preferably through healthcare administration, together, may help remove barriers to PDMP use. PMID:25127880

2014-01-01

466

Esplorazione Della Terra Incognita Della Fisica Nucleare: Nuclei Con Alone, Nuclei "A Grappoli", Nuclei Borromeani e Altre Stranezze Esotiche!  

E-print Network

English: If the current status of theoretical and experimental knowledge in Nuclear Physics could be reduced to a geographical chart or a planisphere, then our epoch would be in some respect comparable to the end of the Medieval age and in other to the beginning of the Reinassance: epochs in which, together with the consolidated knowledge of the Old World, there have been great and revolutionary expeditions as the discovery of America or the periplus of Cape of Good Hope, explorations aimed at reaching the limits that, along the centuries, have lead to more and more engaging scientific discoveries in more and more far away lands, ending only in the twentieth century with the complete mapping of all the continents. Nuclear Physics is living an analogous adventure on the plane of contrast... - Italian: Se lo stato attuale delle conoscenze teoriche e sperimentali della Fisica Nucleare si potesse ridurre a una carta geografica o un mappamondo, allora la nostra epoca si potrebbe paragonare per certi versi alla fine del Medioevo e per altri al Rinascimento: epoche in cui, accanto alla conoscenza consolidata del Vecchio mondo, ci furono grandi e rivoluzionarie spedizioni come la scoperta dell'America o il periplo del Capo di Buona Speranza, esplorazioni geografiche volte al raggiungimento dei limiti che, nel corso dei secoli, hanno portato a scoperte scientifiche sempre pi\\`u avvincenti in terre sempre pi\\`u lontane, culminate solo nel ventesimo secolo con la completa mappatura di tutte le terre emerse. La Fisica Nucleare sta vivendo un'avventura analoga sul piano della contrapposizione tra la conoscenza acquisita sui nuclei stabili e la scoperta delle sorprendenti propriet\\`a esotiche dei nuclei instabili, pi\\`u difficili da produrre, da studiare e da comprendere.

Lorenzo Fortunato

2011-04-04

467

Gender Specific Differences in the Pros and Cons of Smoking among Current Smokers in Eastern Kentucky: Implications for Future Smoking Cessation Interventions  

PubMed Central

This study investigated gender differences in the perceived “pros” and “cons” of smoking using the constructs of decisional balance (DB) and stage of change from the Transtheoretical Model. The population distribution for stage of change among a population-based, cross-sectional survey of 155 current smokers over 40 years was: precontemplation (22.6%), contemplation (41.9%), preparation (35.5%). Results of stepwise regression models indicated significant gender differences in DB were in the preparation stage of change; scores on the DB measure increased 3.94 points (95% CI: 1.94, 5.93) for male smokers. Interventions targeting the “pros” and “cons” of smoking may need to be gender specific. PMID:19190354

Hazen, Dana A.; Mannino, David M.; Clayton, Richard

2008-01-01

468

The School of Ocean and Earth Science and Technology (SOEST) at the University of Hawai`i at Manoa (UHM) has con-  

E-print Network

The School of Ocean and Earth Science and Technology (SOEST) at the University of Hawai`i at M¯anoa (UHM) has con- tracted with Deep Ocean Exploration and Research (DOER) Marine for the design(R/VKM) I n f o r m a t I o n S h e e t SOEST-DOER Marine H6000 RemotelyOperatedVehicle(ROV) SCHOOL OF OCEAN

469

reThiNKiNG The BoUNdaries The dUKe MBa--CroSS ConTInenT  

E-print Network

reThiNKiNG The BoUNdaries The dUKe MBa--CroSS ConTInenT #12;develoP GloBal iNsiGhT The duke MBa--cross continent program is designed to help full-time working professionals earn a world- class MBa while building, The duke MBa-- cross continent program builds more than global awareness; it provides the necessary real

Dolbow, John

470

Compito Comunicazioni Radiomobili: 27 Luglio Si consideri la connessione uplink di un sistema radiomobile con accesso multiplo al canale a divisione  

E-print Network

ogni utente trasmetta con potenza Ptx = 0.25 W, che le perdite nel canale siano uguali per tutti gli calcoli la potenza in trasmissione necessaria affinche' ogni utente raggiunga un Eb/I0 pari a 8 dB nell - P (i) rx + N0W × G(i) #12;2 dove Itot = M j=1 P (j) rx e' la potenza totale ricevuta dalla stazione

Abrardo, Andrea

471

Comparison between Subgenomic Replicons of Hepatitis C Virus Genotypes 2a (JFH-1) and 1b (Con1 NK5.1)  

Microsoft Academic Search

Although replicon systems for hepatitis C virus (HCV) recently developed have enabled the replication of HCV in cultured cells, limited genotypes are available for them. We have isolated HCV cDNA of genotype 2a (JFH-1 strain) from serum of a patient with fulminant hepatitis. A subgenomic replicon of JFH-1 was constructed and compared with the HCV replicon of genotype 1b (Con1

Michiko Miyamoto; Takanobu Kato; Tomoko Date; Masashi Mizokami; Takaji Wakita

2006-01-01

472

Dissection of the Intracellular Pathways in Hepatocytes Suggests a Role for Jun Kinase and IFN Regulatory Factor1 in Con A-Induced Liver Failure1  

Microsoft Academic Search

Con A administration results in dose-dependent immune-mediated liver injury. Cytokines are important to determine the outcome of liver failure in this model, and especially TNF-a and IFN-g directly contribute to hepatocyte damage. The intracellular pathways of these two cytokines, which eventually result in tissue destruction, are not well defined. Here we used anti-IFN-g Abs and adenoviral vectors that express molecules

Konrad Streetz; Bastian Fregien; Jorg Plumpe; Kerstin Korber; Stefan Kubicka; Stephan C. Bischoff; Michael P. Manns; Gisa Tiegs; Christian Trautwein

473

NIDO: Navegación e interacción con el usuario en el desarrollo de sistemas de información Web: Métodos, Técnicas y Herramientas TIC2003-00369  

Microsoft Academic Search

NIDO (Navegación e Interacción con el usuario en el Desarrollo de sistemas de Información Web: Métodos, Técnicas y Herramientas) is a research project with two main lines of research. The first one is to continue with the research developed in the coordinated projects MENHIR (TIC97-0593-C05-03) and DOLMEN (TIC2000-1673-C06-03), while the second one is related to the opening of new research

Jesús Torres

474

A review of the practice of sedation with inhalational anaesthetics in the intensive care unit with the AnaConDa® device  

PubMed Central

The intensive care unit (ICU) environment is often perceived to be hostile and frightening by patients due to unfamiliar surroundings coupled with presence of numerous personnel, monitors and other equipments as well as a loss of perception of time. Mechanical ventilation and multiple painful procedures that often need to be carried out in these critically ill patients add to their overall anxiety. Sedation is therefore required not only to allay the stress and anxiety, but also to allow for mechanical ventilation and other invasive therapeutic and diagnostic procedures to be performed. The conventional intravenous sedative agents used in ICUs suffer from problems of over sedation, tachyphylaxis, drug accumulation, organ specific elimination and often lead to patient agitation on withdrawal. All this tend to prolong the ventilatory as well as ICU and hospital discharge time, which increase the risk for infection and add to the overall increase in morbidity, mortality and hospital costs. In 2005, the anaesthetic conserving device (AnaConDa®) was marketed for ICU sedation with volatile anaesthetic agents. A number of trials have shown the effectiveness of using volatile anaesthetic agents for ICU sedation with the AnaConDa device. Compared with intravenous sedatives, use of volatile anaesthetic agents have resulted in shorter wake up and extubation time, lesser duration of mechanical ventilation and faster discharge from hospitals. This review shall focus on the benefits, technical pre-requisites and status of sedation with volatile anaesthetic agents in ICUs with the AnaConDa® device. PMID:23325934

Misra, Satyajeet; Koshy, Thomas

2012-01-01

475

Emerging and Legacy Contaminants in The Foodweb in The Lower Columbia River: USGS ConHab Project  

NASA Astrophysics Data System (ADS)

An interdisciplinary study, USGS Columbia River Contaminants and Habitat Characterization (ConHab) project, investigates transport pathways, chemical fate, and effects of polybrominated diphenyl ethers (PBDEs) and other endocrine disrupting chemicals (EDCs) in aquatic media and the foodweb in the lower Columbia River, Oregon and Washington. Polar organic chemical integrative samplers (POCIS) and semipermeable membrane devices (SPMDs) were co-deployed at each of 10 sites in 2008 to provide a measure of the dissolved concentrations of select PBDEs, chlorinated pesticides, and other EDCs. PBDE-47 was the most prevalent of the PBDEs detected. Numerous organochlorine pesticides, both banned and current-use, including hexachlorobenzene, pentachloroanisole, dichlorodiphenyltrichloroethane (DDT) and its degradates, chlorpyrifos, endosulfan, and the endosulfan degradation products, were measured at each site. EDCs commonly detected included a series of polycyclic aromatic hydrocarbons (PAHs), fragrances (galaxolide), pesticides (chlorpyrifos and atrazine), plasticizers (phthalates), and flame retardants (phosphates). The downstream sites tended to have the highest concentrations of contaminants in the lower Columbia River. In 2009 and 2010 passive samplers were deployed and resident largescale suckers (Catostomus macrocheilus) and surface bed sediments were collected at three of the original sites representing a gradient of exposure based on 2008 results. Brain, fillet, liver, stomach, and gonad tissues were analyzed. Chemical concentrations were highest in livers, followed by brain, stomach, gonad, and, lastly, fillet. Concentrations of halogenated compounds in tissue samples ranged from <1 to 400 ng g-1 wet tissue. PBDEs, organochlorine pesticides, DDT and its degradates, and polychlorinated biphenyls (PCBs) were detected at all sites in nearly all organs tested. PBDE congeners most frequently detected and at the highest concentrations were PBDE-47 > PBDE-100 > PBDE-154 > PBDE-153. Concentrations in tissues and in sediments increased moving downstream from Skamania, WA to Columbia City, OR to Longview, WA. Preliminary biomarker results indicate that fish at the downstream sites experience greater stress relative to the upstream site based on gonad, kidney, spleen, and liver histopathology. These results support the hypothesis that contaminant concentrations in the environment correlate to bioaccumulation in the foodweb.

Nilsen, E. B.; Alvarez, D.; Counihan, T.; Elias, E.; Gelfenbaum, G. R.; Hardiman, J.; Jenkins, J.; Mesa, M.; Morace, J.; Patino, R.; Torres, L.; Waite, I.; Zaugg, S.

2012-12-01

476

Informe Anual a la Nación sobre el Estado del Cáncer, de 1975 a 2010, con una sección especial sobre la prevalencia de comorbilidad y su efecto en la supervivencia de personas con cáncer de pulmón, seno, próstata o colorrectal: preguntas y respuestas  

Cancer.gov

El Informe Anual a la Nación sobre el Estado del Cáncer (1975 a 2010), mostró un descenso más acelerado que en años anteriores de los índices de mortalidad por cáncer de pulmón. También contiene una sección especial que destaca los efectos significativos que tienen otras enfermedades en la supervivencia de pacientes con cáncer.

477

RISULTATI VALUTAZIONE TITOLI DEL CONCORSO PER L'ASSEGNAZIONE DI N.1 ASSEGNO DI RICERCA PROG. DI RICERCA N. 11.05 BANDITO CON D.R. N.2285 DEL 3.6.2013  

E-print Network

Pubblicazioni su riviste 6 Pubblicazioni su volumi 4 TOTALE 12 DOTT. CASSANO ANDREA: Dottorato di ricerca 10 disponibili, la Commissione decide di ammettere il candidato dott. Cassano Andrea, con punti 31

Malerba, Donato

478

Flight Deck Surface Trajectory-based Operations (STBO): Results of Piloted Simulations and Implications for Concepts of Operation (ConOps)  

NASA Technical Reports Server (NTRS)

The results offour piloted medium-fidelity simulations investigating flight deck surface trajectory-based operations (STBO) will be reviewed. In these flight deck STBO simulations, commercial transport pilots were given taxi clearances with time and/or speed components and required to taxi to the departing runway or an intermediate traffic intersection. Under a variety of concept of operations (ConOps) and flight deck information conditions, pilots' ability to taxi in compliance with the required time of arrival (RTA) at the designated airport location was measured. ConOps and flight deck information conditions explored included: Availability of taxi clearance speed and elapsed time information; Intermediate RTAs at intermediate time constraint points (e.g., intersection traffic flow points); STBO taxi clearances via ATC voice speed commands or datal ink; and, Availability of flight deck display algorithms to reduce STBO RTA error. Flight Deck Implications. Pilot RTA conformance for STBO clearances, in the form of ATC taxi clearances with associated speed requirements, was found to be relatively poor, unless the pilot is required to follow a precise speed and acceleration/deceleration profile. However, following such a precise speed profile results in inordinate head-down tracking of current ground speed, leading to potentially unsafe operations. Mitigating these results, and providing good taxi RTA performance without the associated safety issues, is a flight deck avionics or electronic flight bag (EFB) solution. Such a solution enables pilots to meet the taxi route RTA without moment-by-moment tracking of ground speed. An avionics or EFB "error-nulling" algorithm allows the pilot to view the STBO information when the pilot determines it is necessary and when workload alloys, thus enabling the pilot to spread his/her attention appropriately and strategically on aircraft separation airport navigation, and the many other flight deck tasks concurrently required. Surface Traffic Management (STM) System Implications. The data indicate a number of implications regarding specific parameters for ATC/STM algorithm development. Pilots have a tendency to arrive at RTA points early with slow required speeds, on time for moderate speeds, and late with faster required speeds. This implies that ATC/STM algorithms should operate with middle-range speeds, similar to that of non-STBO taxi performance. Route length has a related effect: Long taxi routes increase the earliness with slow speeds and the lateness with faster speeds. This is likely due to the" open-loop" nature of the task in which the speed error compounds over a longer time with longer routes. Results showed that this may be mitigated by imposing a small number oftime constraint points each with their own RTAs effectively tuming a long route into a series of shorter routes - and thus improving RTA performance. STBO ConOps Implications. Most important is the impact that these data have for NextGen STM system ConOps development. The results of these experiments imply that it is not reasonable to expect pilots to taxi under a "Full STBO" ConOps in which pilots are expected to be at a predictable (x,y) airport location for every time (t). An STBO ConOps with a small number of intermediate time constraint points and the departing runway, however, is feasible, but only with flight deck equipage enabling the use of a display similar to the "error-nulling algorithm/display" tested.

Foyle, David C.; Hooey, Becky L.; Bakowski, Deborah L.

2013-01-01

479

15-Deoxy-?12,14-prostaglandin J2 Reduces Liver Impairment in a Model of ConA-Induced Acute Hepatic Inflammation by Activation of PPAR? and Reduction in NF-?B Activity  

PubMed Central

Objective. 15-Deoxy-?12,14-prostaglandin J2 (15d-PGJ2) reduces inflammation and has been identified as an anti-inflammatory prostaglandin in numerous animal models. In this study, we investigated both effects of 15d-PGJ2 and its protection mechanism in concanavalin A- (ConA-) induced autoimmune hepatitis in mice. Materials and Methods. In vivo, Balb/C mice were injected with ConA (25?mg/kg) to induce acute autoimmune hepatitis, and 15d-PGJ2 (10??g or 25??g) was administered 1?h before the ConA injection. The histological grade, proinflammatory cytokine levels, and NF-?B and PPAR? activity were determined 6, 12, and 24?h after the ConA injection. In vitro, LO2 cells and RAW264.7 cells were pretreated with 15d-PGJ2 (2??M) 1?h before the stimulation with ConA (30??g/mL). The NF-?B and PPAR? activity were determined 30?min after the ConA administration. Results. Pretreatment with 15d-PGJ2 reduced the pathological effects of ConA-induced autoimmune hepatitis and significantly reduced the levels of cytokines after injection. 15d-PGJ2 activated PPAR?, blocked the degradation of I?B?, and inhibited the translocation of NF-?B into the nucleus. Conclusion. These results indicate that 15d-PGJ2 protects against ConA-induced autoimmune hepatitis by reducing proinflammatory cytokines. This reduction in inflammation may correlate with the activation of PPAR? and the reduction in NF-?B activity. PMID:25120564

Chen, Kan; Li, Jingjing; Wang, Junshan; Xia, Yujing; Dai, Weiqi; Wang, Fan; Shen, Miao; Cheng, Ping; Zhang, Yan; Wang, Chengfen; Yang, Jing; Zhu, Rong; Zhang, Huawei; Zheng, Yuanyuan; Lu, Jie; Fan, Zhuoyi; Zhou, Yingqun; Guo, Chuanyong

2014-01-01

480

Estudio de la fotoabsorción y fotoionización de la molécula de alta relevancia atmosférica no a través de los estados Rydberg con la metodología MQDO  

NASA Astrophysics Data System (ADS)

Los procesos de fotoionización son de una importancia fundamental [1] y encuentran aplicación en un gran número de contextos científicos: Astrofísica [2], química de las radiaciones, biología. Los investigadores de dichos campos, necesitan de valores de fiables de secciones eficaces para la fotoionización parcial, la Fotoabsorción, así como para los procesos de fotofragmentación en amplios intervalos espectrales, particularmente en estudios de modelización [3-5]. En este trabajo se ha centrado la atención sobre el oxido nítrico, que se ha considerado apropiado y relevante por varios motivos: por el trascendental papel que representa en la física y química de la alta atmosfera [6], aparte de por estar íntimamente relacionado con los problemas de contaminación. Los procesos de recombinación disociativa [7] del NO, donde los estados Rydberg se encuentran directamente implicados, son relevantes, por ejemplo, en las regiones E y F de la ionosfera [7]. En este trabajo se estudia la fotoionización del NO desde el estado fundamental con la versión molecular del método del orbital de defecto cuántico (MQDO). Para ello se calcula el diferencial de las fuerzas de oscilador parciales que constituyen los canales de fotoionización del NO desde el estado fundamental. La continuidad del diferencial de fuerza de oscilador calculada a través del umbral de fotoionización, esto es, en las regiones del espectro discreta y del continua, se adopta como criterio de calidad la escasez de datos comparativos [8].

Bustos, E.; Velasco, A. M.; Martín, I.; Lavín, C.

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