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Sample records for radiolucent electrode array

  1. Micromachined electrode array

    DOEpatents

    Okandan, Murat; Wessendorf, Kurt O.

    2007-12-11

    An electrode array is disclosed which has applications for neural stimulation and sensing. The electrode array, in certain embodiments, can include a plurality of electrodes each of which is flexibly attached to a common substrate using a plurality of springs to allow the electrodes to move independently. In other embodiments of the electrode array, the electrodes can be fixed to the substrate. The electrode array can be formed from a combination of bulk and surface micromachining, and can include electrode tips having an electroplated metal (e.g. platinum, iridium, gold or titanium) or a metal oxide (e.g. iridium oxide) for biocompatibility. The electrode array can be used to form a part of a neural prosthesis, and is particularly well adapted for use in an implantable retinal prosthesis.

  2. Flexible retinal electrode array

    DOEpatents

    Okandan, Murat; Wessendorf, Kurt O.; Christenson, Todd R.

    2006-10-24

    An electrode array which has applications for neural stimulation and sensing. The electrode array can include a large number of electrodes each of which is flexibly attached to a common substrate using a plurality of springs to allow the electrodes to move independently. The electrode array can be formed from a combination of bulk and surface micromachining, with electrode tips that can include an electroplated metal (e.g. platinum, iridium, gold or titanium) or a metal oxide (e.g. iridium oxide) for biocompatibility. The electrode array can be used to form a part of a neural prosthesis, and is particularly well adapted for use in an implantable retinal prosthesis where the electrodes can be tailored to provide a uniform gentle contact pressure with optional sensing of this contact pressure at one or more of the electrodes.

  3. Electrode array for neural stimulation

    DOEpatents

    Wessendorf, Kurt O.; Okandan, Murat; Stein, David J.; Yang, Pin; Cesarano, III, Joseph; Dellinger, Jennifer

    2011-08-16

    An electrode array for neural stimulation is disclosed which has particular applications for use in a retinal prosthesis. The electrode array can be formed as a hermetically-sealed two-part ceramic package which includes an electronic circuit such as a demultiplexer circuit encapsulated therein. A relatively large number (up to 1000 or more) of individually-addressable electrodes are provided on a curved surface of a ceramic base portion the electrode array, while a much smaller number of electrical connections are provided on a ceramic lid of the electrode array. The base and lid can be attached using a metal-to-metal seal formed by laser brazing. Electrical connections to the electrode array can be provided by a flexible ribbon cable which can also be used to secure the electrode array in place.

  4. Electrodynamic Arrays Having Nanomaterial Electrodes

    NASA Technical Reports Server (NTRS)

    Trigwell, Steven (Inventor); Biris, Alexandru S. (Inventor); Calle, Carlos I. (Inventor)

    2013-01-01

    An electrodynamic array of conductive nanomaterial electrodes and a method of making such an electrodynamic array. In one embodiment, a liquid solution containing nanomaterials is deposited as an array of conductive electrodes on a substrate, including rigid or flexible substrates such as fabrics, and opaque or transparent substrates. The nanomaterial electrodes may also be grown in situ. The nanomaterials may include carbon nanomaterials, other organic or inorganic nanomaterials or mixtures.

  5. Coated carbon nanotube array electrodes

    DOEpatents

    Ren, Zhifeng; Wen, Jian; Chen, Jinghua; Huang, Zhongping; Wang, Dezhi

    2008-10-28

    The present invention provides conductive carbon nanotube (CNT) electrode materials comprising aligned CNT substrates coated with an electrically conducting polymer, and the fabrication of electrodes for use in high performance electrical energy storage devices. In particular, the present invention provides conductive CNTs electrode material whose electrical properties render them especially suitable for use in high efficiency rechargeable batteries. The present invention also provides methods for obtaining surface modified conductive CNT electrode materials comprising an array of individual linear, aligned CNTs having a uniform surface coating of an electrically conductive polymer such as polypyrrole, and their use in electrical energy storage devices.

  6. Coated carbon nanotube array electrodes

    DOEpatents

    Ren, Zhifeng; Wen, Jian; Chen, Jinghua; Huang, Zhongping; Wang, Dezhi

    2006-12-12

    The present invention provides conductive carbon nanotube (CNT) electrode materials comprising aligned CNT substrates coated with an electrically conducting polymer, and the fabrication of electrodes for use in high performance electrical energy storage devices. In particular, the present invention provides conductive CNTs electrode material whose electrical properties render them especially suitable for use in high efficiency rechargeable batteries. The present invention also provides methods for obtaining surface modified conductive CNT electrode materials comprising an array of individual linear, aligned CNTs having a uniform surface coating of an electrically conductive polymer such as polypyrrole, and their use in electrical energy storage devices.

  7. Stretchable Micro-Electrode Array

    SciTech Connect

    Maghribi, M; Hamilton, J; Polla, D; Rose, K; Wilson, T; Krulevitch, P

    2002-03-08

    This paper focuses on the design consideration, fabrication processes and preliminary testing of the stretchable micro-electrode array. We are developing an implantable, stretchable micro-electrode array using polymer-based microfabrication techniques. The device will serve as the interface between an electronic imaging system and the human eye, directly stimulating retinal neurons via thin film conducting traces and electroplated electrodes. The metal features are embedded within a thin ({approx}50 micron) substrate fabricated using poly (dimethylsiloxane) (PDMS), a biocompatible elastomeric material that has very low water permeability. The conformable nature of PDMS is critical for ensuring uniform contact with the curved surface of the retina. To fabricate the device, we developed unique processes for metalizing PDMS to produce robust traces capable of maintaining conductivity when stretched (5%, SD 1.5), and for selectively passivating the conductive elements. An in situ measurement of residual strain in the PDMS during curing reveals a tensile strain of 10%, explaining the stretchable nature of the thin metalized devices.

  8. Virtual electrodes for high-density electrode arrays

    DOEpatents

    Cela, Carlos J.; Lazzi, Gianluca

    2015-10-13

    The present embodiments are directed to implantable electrode arrays having virtual electrodes. The virtual electrodes may improve the resolution of the implantable electrode array without the burden of corresponding complexity of electronic circuitry and wiring. In a particular embodiment, a virtual electrode may include one or more passive elements to help steer current to a specific location between the active electrodes. For example, a passive element may be a metalized layer on a substrate that is adjacent to, but not directly connected to an active electrode. In certain embodiments, an active electrode may be directly coupled to a power source via a conductive connection. Beneficially, the passive elements may help to increase the overall resolution of the implantable array by providing additional stimulation points without requiring additional wiring or driver circuitry for the passive elements.

  9. Optimization of return electrodes in neurostimulating arrays

    NASA Astrophysics Data System (ADS)

    Flores, Thomas; Goetz, Georges; Lei, Xin; Palanker, Daniel

    2016-06-01

    Objective. High resolution visual prostheses require dense stimulating arrays with localized inputs of individual electrodes. We study the electric field produced by multielectrode arrays in electrolyte to determine an optimal configuration of return electrodes and activation sequence. Approach. To determine the boundary conditions for computation of the electric field in electrolyte, we assessed current dynamics using an equivalent circuit of a multielectrode array with interleaved return electrodes. The electric field modeled with two different boundary conditions derived from the equivalent circuit was then compared to measurements of electric potential in electrolyte. To assess the effect of return electrode configuration on retinal stimulation, we transformed the computed electric fields into retinal response using a model of neural network-mediated stimulation. Main results. Electric currents at the capacitive electrode-electrolyte interface redistribute over time, so that boundary conditions transition from equipotential surfaces at the beginning of the pulse to uniform current density in steady state. Experimental measurements confirmed that, in steady state, the boundary condition corresponds to a uniform current density on electrode surfaces. Arrays with local return electrodes exhibit improved field confinement and can elicit stronger network-mediated retinal response compared to those with a common remote return. Connecting local return electrodes enhances the field penetration depth and allows reducing the return electrode area. Sequential activation of the pixels in large monopolar arrays reduces electrical cross-talk and improves the contrast in pattern stimulation. Significance. Accurate modeling of multielectrode arrays helps optimize the electrode configuration to maximize the spatial resolution, contrast and dynamic range of retinal prostheses.

  10. Algal biosensor array on a single electrode.

    PubMed

    Tatsuma, Tetsu; Yoshida, Yutaka; Shitanda, Isao; Notsu, Hideo

    2009-02-01

    An algal array was prepared on a single transparent electrode, and photosynthetic activity of each algal channel and its inhibition by a toxin were monitored with a single-channel potentiostat by successive light irradiation with a LED array. PMID:19173040

  11. Microminiature molding techniques for cochlear electrode arrays.

    PubMed

    Loeb, G E; Peck, R A; Smith, D W

    1995-12-01

    We provide a general method for producing a variety of small, complex electrode arrays based on injection molds produced using computer-aided drafting and machining (CAD-CAM) procedures and a novel method for connecting to the very fine electrical leads associated with the individual contacts of such arrays. Cat-sized cochlear electrode arrays with up to eight contacts were built according to these methods and their electrical contacts were characterized in vitro by impedance spectroscopy and in vivo by monitoring impedance for over 1 year of intermittent stimulation in chronically instrumented animals. PMID:8788052

  12. Optically transparent multi-suction electrode arrays

    PubMed Central

    Nagarah, John M.; Stowasser, Annette; Parker, Rell L.; Asari, Hiroki; Wagenaar, Daniel A.

    2015-01-01

    Multielectrode arrays (MEAs) allow for acquisition of multisite electrophysiological activity with submillisecond temporal resolution from neural preparations. The signal to noise ratio from such arrays has recently been improved by substrate perforations that allow negative pressure to be applied to the tissue; however, such arrays are not optically transparent, limiting their potential to be combined with optical-based technologies. We present here multi-suction electrode arrays (MSEAs) in quartz that yield a substantial increase in the detected number of units and in signal to noise ratio from mouse cortico-hippocampal slices and mouse retina explants. This enables the visualization of stronger cross correlations between the firing rates of the various sources. Additionally, the MSEA's transparency allows us to record voltage sensitive dye activity from a leech ganglion with single neuron resolution using widefield microscopy simultaneously with the electrode array recordings. The combination of enhanced electrical signals and compatibility with optical-based technologies should make the MSEA a valuable tool for investigating neuronal circuits. PMID:26539078

  13. Transparent metal electrodes from ordered nanosphere arrays

    NASA Astrophysics Data System (ADS)

    Morfa, Anthony J.; Akinoglu, Eser M.; Subbiah, Jegadesan; Giersig, Michael; Mulvaney, Paul

    2013-08-01

    We show that perforated metal electrode arrays, fabricated using nanosphere lithography, provide a viable alternative to conductive metal oxides as transparent electrode materials. The inter-aperture spacing is tuned by varying etching times in an oxygen plasma, and the effect of inter-aperture "wire" thickness on the optical and electronic properties of perforated silver films is shown. Optical transmission is limited by reflection and surface plasmons, and for these results do not exceed 73%. Electrical sheet resistance is shown to be as low as 3 Ω ◻-1 for thermally evaporated silver films. The performance of organic photovoltaic devices comprised of a P3HT:PCBM bulk heterojunction deposited onto perforated metal arrays is shown to be limited by optical transmission, and a simple model is presented to overcome these limitations.

  14. Integrated Arrays of Ion-Sensitive Electrodes

    NASA Technical Reports Server (NTRS)

    Buehler, Martin; Kuhlman, Kimberly

    2003-01-01

    The figure depicts an example of proposed compact water-quality sensors that would contain integrated arrays of ion-sensitive electrodes (ISEs). These sensors would serve as electronic "tongues": they would be placed in contact with water and used to "taste" selected dissolved ions (that is, they would be used to measure the concentrations of the ions). The selected ions could be any or all of a variety of organic and inorganic cations and anions that could be regarded as contaminants or analytes, depending on the specific application. In addition, some of the ISEs could be made sensitive to some neutral analytes

  15. Silicon-based wire electrode array for neural interfaces

    NASA Astrophysics Data System (ADS)

    Pei, Weihua; Zhao, Hui; Zhao, Shanshan; Fang, Xiaolei; Chen, Sanyuan; Gui, Qiang; Tang, Rongyu; Chen, Yuanfang; Hong, Bo; Gao, Xiaorong; Chen, Hongda

    2014-09-01

    Objectives. Metal-wire electrode arrays are widely used to record and stimulate neurons. Commonly, these devices are fabricated from a long insulated metal wire by cutting it into the proper length and using the cross-section as the electrode site. The assembly of a micro-wire electrode array with regular spacing is difficult. With the help of micro-machine technology, a silicon-based wire electrode array (SWEA) is proposed to simplify the assembling process and provide a wire-type electrode with tapered tips. Approach. Silicon wires with regular spacing coated with metal are generated from a silicon wafer through micro-fabrication and are ordered into a 3D array. A silicon wafer is cut into a comb-like structure with hexagonal teeth on both sides by anisotropic etching. To establish an array of silicon-based linear needles through isotropic wet etching, the diameters of these hexagonal teeth are reduced; their sharp edges are smoothed out and their tips are sharpened. The needle array is coated with a layer of parylene after metallization. The tips of the needles are then exposed to form an array of linear neural electrodes. With these linear electrode arrays, an array of area electrodes can be fabricated. Main results. A 6  ×  6 array of wire-type electrodes based on silicon is developed using this method. The time required to manually assemble the 3D array decreases significantly with the introduction of micro-fabricated 2D array. Meanwhile, the tip intervals in the 2D array are accurate and are controlled at no more than 1%. The SWEA is effective both in vitro and in vivo. Significance. Using this method, the SWEA can be batch-prepared in advance along with its parameters, such as spacing, length, and diameter. Thus, neural scientists can assemble proper electrode arrays in a short time.

  16. Method for the electro-addressable functionalization of electrode arrays

    SciTech Connect

    Harper, Jason C.; Polsky, Ronen; Dirk, Shawn M.; Wheeler, David R.; Arango, Dulce C.; Brozik, Susan M.

    2015-12-15

    A method for preparing an electrochemical biosensor uses bias-assisted assembly of unreactive -onium molecules on an electrode array followed by post-assembly electro-addressable conversion of the unreactive group to a chemical or biological recognition group. Electro-addressable functionalization of electrode arrays enables the multi-target electrochemical sensing of biological and chemical analytes.

  17. A Flexible Base Electrode Array for Intraspinal Microstimulation

    PubMed Central

    Khaled, I.; Elmallah, S.; Cheng, C.; Moussa, W.A.; Mushahwar, V.K.; Elias, A.L.

    2013-01-01

    In this paper, we report the development of a flexible base array of penetrating electrodes which can be used to interface with the spinal cord. A customizable and feasible fabrication protocol is described. The flexible base arrays were fabricated and implanted into surrogate cords which were elongated by 12%. The resulting strains were optically measured across the cord and compared to those associated with two types of electrodes arrays (one without a base and one with a rigid base connecting the electrodes). The deformation behavior of cords implanted with the flexible base arrays resembled the behavior of cords implanted with individual microwires that were not connected through a base. The results of the strain test were used to validate a 2D finite element model. The validated model was used to assess the stresses induced by the electrodes of the 3 types of arrays on the cord, and to examine how various design parameters (thickness, base modulus, etc.) impact the mechanical behavior of the electrode array. Rigid base arrays induced higher stresses on the cord than the flexible base arrays which in turn imposed higher stresses than the individual microwire implants. The developed flexible base array showed improvement over the rigid base array; however, its stiffness needs to be further reduced to emulate the mechanical behavior of individual microwire arrays without a base. PMID:23744656

  18. Modiolus-hugging intracochlear electrode array with shape memory alloy.

    PubMed

    Min, Kyou Sik; Jun, Sang Beom; Lim, Yoon Seob; Park, Se-Ik; Kim, Sung June

    2013-01-01

    In the cochlear implant system, the distance between spiral ganglia and the electrodes within the volume of the scala tympani cavity significantly affects the efficiency of the electrical stimulation in terms of the threshold current level and spatial selectivity. Because the spiral ganglia are situated inside the modiolus, the central axis of the cochlea, it is desirable that the electrode array hugs the modiolus to minimize the distance between the electrodes and the ganglia. In the present study, we propose a shape-memory-alloy-(SMA-) embedded intracochlear electrode which gives a straight electrode a curved modiolus-hugging shape using the restoration force of the SMA as triggered by resistive heating after insertion into the cochlea. An eight-channel ball-type electrode array is fabricated with an embedded titanium-nickel SMA backbone wire. It is demonstrated that the electrode array changes its shape in a transparent plastic human cochlear model. To verify the safe insertion of the electrode array into the human cochlea, the contact pressures during insertion at the electrode tip and the contact pressures over the electrode length after insertion were calculated using a 3D finite element analysis. The results indicate that the SMA-embedded electrode is functionally and mechanically feasible for clinical applications. PMID:23762181

  19. 3D electrical tomographic imaging using vertical arrays of electrodes

    NASA Astrophysics Data System (ADS)

    Murphy, S. C.; Stanley, S. J.; Rhodes, D.; York, T. A.

    2006-11-01

    Linear arrays of electrodes in conjunction with electrical impedance tomography have been used to spatially interrogate industrial processes that have only limited access for sensor placement. This paper explores the compromises that are to be expected when using a small number of vertically positioned linear arrays to facilitate 3D imaging using electrical tomography. A configuration with three arrays is found to give reasonable results when compared with a 'conventional' arrangement of circumferential electrodes. A single array yields highly localized sensitivity that struggles to image the whole space. Strategies have been tested on a small-scale version of a sludge settling application that is of relevance to the industrial sponsor. A new electrode excitation strategy, referred to here as 'planar cross drive', is found to give superior results to an extended version of the adjacent electrodes technique due to the improved uniformity of the sensitivity across the domain. Recommendations are suggested for parameters to inform the scale-up to industrial vessels.

  20. Optimal configuration of an electrode array for measuring ventricles' contraction

    NASA Astrophysics Data System (ADS)

    Lewandowska, M.; Poliński, A.; Truyen, B.; Wtorek, J.

    2013-04-01

    An influence of an electrode-array configuration on an impedance signal composition for a fixed spatial distribution of its sources is examined in the paper. The Finite Element Method and Geselowitz relationship were used for examining three different electrode-arrays. A sensitivity approach was used to evaluate each configuration assuming that localization of the signal source is known. A conductivity change, thus the source of the impedance signal was considered as two hemispheres covered by a shell.

  1. Recording and assessment of evoked potentials with electrode arrays.

    PubMed

    Miljković, N; Malešević, N; Kojić, V; Bijelić, G; Keller, T; Popović, D B

    2015-09-01

    In order to optimize procedure for the assessment of evoked potentials and to provide visualization of the flow of action potentials along the motor systems, we introduced array electrodes for stimulation and recording and developed software for the analysis of the recordings. The system uses a stimulator connected to an electrode array for the generation of evoked potentials, an electrode array connected to the amplifier, A/D converter and computer for the recording of evoked potentials, and a dedicated software application. The method has been tested for the assessment of the H-reflex on the triceps surae muscle in six healthy humans. The electrode array with 16 pads was positioned over the posterior aspect of the thigh, while the recording electrode array with 16 pads was positioned over the triceps surae muscle. The stimulator activated all the pads of the stimulation electrode array asynchronously, while the signals were recorded continuously at all the recording sites. The results are topography maps (spatial distribution of evoked potentials) and matrices (spatial visualization of nerve excitability). The software allows the automatic selection of the lowest stimulation intensity to achieve maximal H-reflex amplitude and selection of the recording/stimulation pads according to predefined criteria. The analysis of results shows that the method provides rich information compared with the conventional recording of the H-reflex with regard the spatial distribution. PMID:25863691

  2. Neuro-Prosthetic Implants With Adjustable Electrode Arrays

    NASA Technical Reports Server (NTRS)

    Whitacre, Jay; DelCastillo, Linda Y.; Mojarradi, Mohammad; Johnson, Travis; West, William; Andersen, Richard

    2006-01-01

    Brushlike arrays of electrodes packaged with application-specific integrated circuits (ASICs) are undergoing development for use as electronic implants especially as neuro-prosthetic devices that might be implanted in brains to detect weak electrical signals generated by neurons. These implants partly resemble the ones reported in Integrated Electrode Arrays for Neuro-Prosthetic Implants (NPO-21198), NASA Tech Briefs, Vol. 27, No. 2 (February 2003), page 48. The basic idea underlying both the present and previously reported implants is that the electrodes would pick up signals from neurons and the ASICs would amplify and otherwise preprocess the signals for monitoring by external equipment. The figure presents a simplified and partly schematic view of an implant according to the present concept. Whereas the electrodes in an implant according to the previously reported concept would be microscopic wires, the electrodes according to the present concept are in the form of microscopic needles. An even more important difference would be that, unlike the previously reported concept, the present concept calls for the inclusion of microelectromechanical actuators for adjusting the depth of penetration of the electrodes into brain tissue. The prototype implant now under construction includes an array of 100 electrodes and corresponding array of electrode contact pads formed on opposite faces of a plate fabricated by techniques that are established in the art of microelectromechanical systems (MEMS). A mixed-signal ASIC under construction at the time of reporting the information for this article will include 100 analog amplifier channels (one amplifier per electrode). On one face of the mixed-signal ASIC there will be a solder-bump/micro-pad array that will have the same pitch as that of the electrode array, and that will be used to make the electrical and mechanical connections between the electrode array and the ASIC. Once the electrode array and the ASIC are soldered

  3. Developing barbed microtip-based electrode arrays for biopotential measurement.

    PubMed

    Hsu, Li-Sheng; Tung, Shu-Wei; Kuo, Che-Hsi; Yang, Yao-Joe

    2014-01-01

    This study involved fabricating barbed microtip-based electrode arrays by using silicon wet etching. KOH anisotropic wet etching was employed to form a standard pyramidal microtip array and HF/HNO3 isotropic etching was used to fabricate barbs on these microtips. To improve the electrical conductance between the tip array on the front side of the wafer and the electrical contact on the back side, a through-silicon via was created during the wet etching process. The experimental results show that the forces required to detach the barbed microtip arrays from human skin, a polydimethylsiloxane (PDMS) polymer, and a polyvinylchloride (PVC) film were larger compared with those required to detach microtip arrays that lacked barbs. The impedances of the skin-electrode interface were measured and the performance levels of the proposed dry electrode were characterized. Electrode prototypes that employed the proposed tip arrays were implemented. Electroencephalogram (EEG) and electrocardiography (ECG) recordings using these electrode prototypes were also demonstrated. PMID:25014098

  4. Ultramicroelectrode array behavior of one-dimensional organic conductor electrodes.

    PubMed

    Freund, M S; Brajter-Toth, A

    1989-05-01

    Tetrathiafulvalene-tetracyanoquinodimethane (TTF-TCNQ) electrodes were prepared by two methods that produced electrodes with different structures. This was confirmed by scanning electron microscopy, which also revealed the ultramicroelectrode arraylike structure of TTF-TCNQ electrodes. Electrochemical behavior at both types of electrodes followed the predictions of the theory for ultramicroelectrode arrays. At the two types of surfaces that were prepared, apparent electrochemical rate constants of ferricyanide and ascorbate were different. The resulting changes in the apparent rate constants of redox couples such as ferricyanide and ascorbate as a function of surface structure suggest that at TTF-TCNQ control over reactivity can be achieved through structural manipulation. PMID:2729599

  5. System of fabricating a flexible electrode array

    DOEpatents

    Krulevitch, Peter; Polla, Dennis L.; Maghribi, Mariam N.; Hamilton, Julie; Humayun, Mark S.; Weiland, James D.

    2010-10-12

    An image is captured or otherwise converted into a signal in an artificial vision system. The signal is transmitted to the retina utilizing an implant. The implant consists of a polymer substrate made of a compliant material such as poly(dimethylsiloxane) or PDMS. The polymer substrate is conformable to the shape of the retina. Electrodes and conductive leads are embedded in the polymer substrate. The conductive leads and the electrodes transmit the signal representing the image to the cells in the retina. The signal representing the image stimulates cells in the retina.

  6. System of fabricating a flexible electrode array

    DOEpatents

    Krulevitch, Peter; Polla, Dennis L.; Maghribi, Mariam N.; Hamilton, Julie; Humayun, Mark S.; Weiland, James D.

    2012-01-28

    An image is captured or otherwise converted into a signal in an artificial vision system. The signal is transmitted to the retina utilizing an implant. The implant consists of a polymer substrate made of a compliant material such as poly(dimethylsiloxane) or PDMS. The polymer substrate is conformable to the shape of the retina. Electrodes and conductive leads are embedded in the polymer substrate. The conductive leads and the electrodes transmit the signal representing the image to the cells in the retina. The signal representing the image stimulates cells in the retina.

  7. Flexible electrode array for artifical vision

    DOEpatents

    Krulevitch, Peter; Polla, Dennis L.; Maghribi, Mariam N.; Hamilton, Julie

    2006-12-05

    An image is captured or otherwise converted into a signal in an artificial vision system. The signal is transmitted to the retina utilizing an implant. The implant consists of a polymer substrate made of a compliant material such as poly(dimethylsiloxane) or PDMS. The polymer substrate is conformable to the shape of the retina. Electrodes and conductive leads are embedded in the polymer substrate. The conductive leads and the electrodes transmit the signal representing the image to the cells in the retina. The signal representing the image stimulates cells in the retina.

  8. Density controlled carbon nanotube array electrodes

    DOEpatents

    Ren, Zhifeng F.; Tu, Yi

    2008-12-16

    CNT materials comprising aligned carbon nanotubes (CNTs) with pre-determined site densities, catalyst substrate materials for obtaining them and methods for forming aligned CNTs with controllable densities on such catalyst substrate materials are described. The fabrication of films comprising site-density controlled vertically aligned CNT arrays of the invention with variable field emission characteristics, whereby the field emission properties of the films are controlled by independently varying the length of CNTs in the aligned array within the film or by independently varying inter-tubule spacing of the CNTs within the array (site density) are disclosed. The fabrication of microelectrode arrays (MEAs) formed utilizing the carbon nanotube material of the invention is also described.

  9. Fabrication of Pillar Shaped Electrode Arrays for Artificial Retinal Implants

    PubMed Central

    Kim, Eui Tae; Seo, Jong-Mo; Woo, Se Joon; Zhou, Jing Ai; Chung, Hum; Kim, Sung June

    2008-01-01

    Polyimide has been widely applied to neural prosthetic devices, such as the retinal implants, due to its well-known biocompatibility and ability to be micropatterned. However, planar films of polyimide that are typically employed show a limited ability in reducing the distance between electrodes and targeting cell layers, which limits site resolution for effective multi-channel stimulation. In this paper, we report a newly designed device with a pillar structure that more effectively interfaces with the target. Electrode arrays were successfully fabricated and safely implanted inside the rabbit eye in suprachoroidal space. Optical Coherence Tomography (OCT) showed well-preserved pillar structures of the electrode without damage. Bipolar stimulation was applied through paired sites (6:1) and the neural responses were successfully recorded from several regions in the visual cortex. Electrically evoked cortical potential by the pillar electrode array stimulation were compared to visual evoked potential under full-field light stimulation.

  10. Graphene Transparent Conductive Electrodes for Next- Generation Microshutter Arrays

    NASA Technical Reports Server (NTRS)

    Li, Mary; Sultana, Mahmooda; Hess, Larry

    2012-01-01

    Graphene is a single atomic layer of graphite. It is optically transparent and has high electron mobility, and thus has great potential to make transparent conductive electrodes. This invention contributes towards the development of graphene transparent conductive electrodes for next-generation microshutter arrays. The original design for the electrodes of the next generation of microshutters uses indium-tin-oxide (ITO) as the electrode material. ITO is widely used in NASA flight missions. The optical transparency of ITO is limited, and the material is brittle. Also, ITO has been getting more expensive in recent years. The objective of the invention is to develop a graphene transparent conductive electrode that will replace ITO. An exfoliation procedure was developed to make graphene out of graphite crystals. In addition, large areas of single-layer graphene were produced using low-pressure chemical vapor deposition (LPCVD) with high optical transparency. A special graphene transport procedure was developed for transferring graphene from copper substrates to arbitrary substrates. The concept is to grow large-size graphene sheets using the LPCVD system through chemical reaction, transfer the graphene film to a substrate, dope graphene to reduce the sheet resistance, and pattern the film to the dimension of the electrodes in the microshutter array. Graphene transparent conductive electrodes are expected to have a transparency of 97.7%. This covers the electromagnetic spectrum from UV to IR. In comparison, ITO electrodes currently used in microshutter arrays have 85% transparency in mid-IR, and suffer from dramatic transparency drop at a wavelength of near-IR or shorter. Thus, graphene also has potential application as transparent conductive electrodes for Schottky photodiodes in the UV region.

  11. Electrochemical DNA biosensor based on the BDD nanograss array electrode

    PubMed Central

    2013-01-01

    Background The development of DNA biosensor has attracted considerable attention due to their potential applications, including gene analysis, clinical diagnostics, forensic study and more medical applications. Using electroactive daunomycin as an indicator, the hybridization detection was measured by differential pulse voltammetry in this study. Results Electrochemical DNA biosensor was developed based on the BDD film electrode (fBDD) and BDD nanograss array electrode (nBDD). In comparison with fBDD and AuNPs/CA/fBDD electrode, the lower semicircle diameter of electrochemical impedance spectroscopy obtained on nBDD and AuNPs/CA/nBDD electrode indicated that the presence of nanograss array improved the reactive site, reduced the interfacial resistance, and made the electron transfer easier. Using electroactive daunomycin as an indicator, the hybridization detection was measured by differential pulse voltammetry. Conclusions The experimental results demonstrated that the prepared AuNPs/CA/nBDD electrode was suitable for DNA hybridization with favorable performance of faster response, higher sensitivity, lower detection limit and satisfactory selectivity, reproducibility and stability. PMID:23575250

  12. The rational for a mid-scala electrode array.

    PubMed

    Boyle, P J

    2016-06-01

    Today increasing numbers of cochlear implant candidates have residual hearing that can be aided and hence is worth trying to preserve. This means that surgical technique and electrode array design must be adapted to minimize trauma. Wide opening of the round window is often preferred to reduce drill related trauma and to avoid pressure spikes during electrode array insertion. A recent meta-analysis suggested that there is no significant correlation between hearing preservation and either insertion depth or scala position. However, a slow insertion speed of at least 30seconds was associated with better hearing preservation. An electrode design is proposed that targets the middle of the scala tympani. This minimizes frictional forces from either lateral or medial wall during insertion and imposes less static pressure on cochlear structures following insertion. The flexibility to insert via the round window requires a 0.7-mm maximum dimension at the proximal end of the array. Micro-anatomical analysis by micro-CT indicated that a 420-degree insertion depth was optimal between cochlear coverage and available space within the scala tympani. Physical measurements showed that mean insertion forces remained below 10mN during insertion. A series of 20 human temporal bone insertions found a mean insertion depth of 400 degrees with no scala dislocations. Six clinical series, in total 94 cases, found postoperative hearing in 81% of cases with a mean loss of 12dB compared to preoperative levels. Speech understanding out to one year post-fitting trended better for a mid-scala design group than for a straight electrode array group; although the differences were not statistically significant. A mid-scala array design appears able to be inserted with minimal trauma, to return a predictable insertion depth across various sizes of cochleae and to support reasonable levels of speech understanding without relying on residual hearing. PMID:27246747

  13. Chronic impedance spectroscopy of an endovascular stent-electrode array

    NASA Astrophysics Data System (ADS)

    Opie, Nicholas L.; John, Sam E.; Rind, Gil S.; Ronayne, Stephen M.; Grayden, David B.; Burkitt, Anthony N.; May, Clive N.; O’Brien, Terence J.; Oxley, Thomas J.

    2016-08-01

    Objective. Recently, we reported a minimally invasive stent-electrode array capable of recording neural signals from within a blood vessel. We now investigate the use of electrochemical impedance spectroscopy (EIS) measurements to infer changes occurring to the electrode–tissue interface from devices implanted in a cohort of sheep for up to 190 days. Approach. In a cohort of 15 sheep, endovascular stent-electrode arrays were implanted in the superior sagittal sinus overlying the motor cortex for up to 190 days. EIS was performed routinely to quantify viable electrodes for up to 91 days. An equivalent circuit model (ECM) was developed from the in vivo measurements to characterize the electrode–tissue interface changes occurring to the electrodes chronically implanted within a blood vessel. Post-mortem histological assessment of stent and electrode incorporation into the wall of the cortical vessels was compared to the electrical impedance measurements. Main results. EIS could be used to infer electrode viability and was consistent with x-ray analysis performed in vivo, and post-mortem evaluation. Viable electrodes exhibited consistent 1 kHz impedances across the 91 day measurement period, with the peak resistance frequency for the acquired data also stable over time. There was a significant change in 100 Hz phase angles, increasing from ‑67.8° ± 8.8° at day 0 to ‑43.8° ± 0.8° at day 91, which was observed to stabilize after eight days. ECM’s modeled to the data suggested this change was due to an increase in the capacitance of the electrode–tissue interface. This was supported by histological assessment with >85% of the implanted stent struts covered with neointima and incorporated into the blood vessel within two weeks. Conclusion. This work demonstrated that EIS could be used to determine the viability of electrode implanted chronically within a blood vessel. Impedance measurements alone were not observed to be a useful predictor of alterations

  14. Preparation, applications, and digital simulation of carbon interdigitated array electrodes.

    PubMed

    Liu, Fei; Kolesov, Grigory; Parkinson, B A

    2014-08-01

    Carbon interdigitated array (IDA) electrodes with features sizes down to 1.2 μm were fabricated by controlled pyrolysis of patterned photoresist. Cyclic voltammetry of reversible redox species produced the expected steady-state currents. The collection efficiency depends on the IDA electrode spacing, which ranged from around 2.7 to 16.5 μm, with the smaller dimensions achieving higher collection efficiencies of up to 98%. The signal amplification because of redox cycling makes it possible to detect species at relatively low concentrations (10(-5) molar) and the small spacing allows detection of transient electrogenerated species with much shorter lifetimes (submillisecond). Digital simulation software that accounts for both the width and height of electrode elements as well as the electrode spacing was developed to model the IDA electrode response. The simulations are in quantitative agreement with experimental data for both a simple fast one electron redox reaction and an electron transfer with a following chemical reaction at the IDAs with larger gaps whereas currents measured for the smallest IDA electrodes, that were larger than the simulated currents, are attributed to convection from induced charge electrokinetic flow. PMID:24998907

  15. Preparation, Applications, and Digital Simulation of Carbon Interdigitated Array Electrodes

    SciTech Connect

    Liu, Fei; Kolesov, Grigory; Parkinson, Bruce A.

    2014-12-16

    Carbon interdigitated array (IDA) electrodes with features sizes down to 1.2 μm were fabricated by controlled pyrolysis of patterned photoresist. Cyclic voltam-metry of reversible redox species produced the expected steady-state currents. The collection efficiency depends on the IDA electrode spacing, which ranged from around 2.7 to 16.5 μm, with the smaller dimensions achieving higher collection efficiencies of up to 98%. The signal amplification because of redox cycling makes it possible to detect species at relatively low concentrations (10–5 molar) and the small spacing allows detection of transient electrogenerated species with much shorter lifetimes (submillisecond). Digital simulation software that accounts for both the width and height of electrode elements as well as the electrode spacing was developed to model the IDA electrode response. The simulations are in quantitative agreement with experimental data for both a simple fast one electron redox reaction and an electron transfer with a following chemical reaction at the IDAs with larger gaps whereas currents measured for the smallest IDA electrodes, that were larger than the simulated currents, are attributed to convection from induced charge electrokinetic flow. This work was supported as part of the Center for Molecular Electrocatalysis, an Energy Frontier Research Center funded by the Department of Energy, Office of Science Office of Basic Energy Sciences.

  16. Cell pairing using microwell array electrodes based on dielectrophoresis.

    PubMed

    Yoshimura, Yuki; Tomita, Masahiro; Mizutani, Fumio; Yasukawa, Tomoyuki

    2014-07-15

    We report a simple device with an array of 10,000 (100 × 100) microwells for producing vertical pairs of cells in individual microwells with a rapid manipulation based on positive dielectrophoresis (p-DEP). The areas encircled with micropoles which fabricated from an electrical insulating photosensitive polymer were used as microwells. The width (14 μm) and depth (25 μm) of the individual microwells restricted the size to two vertically aligned cells. The DEP device for the manipulation of cells consisted of a microfluidic channel with an upper indium tin oxide (ITO) electrode and a lower microwell array electrode fabricated on an ITO substrate. Mouse myeloma cells stained in green were trapped within 1 s in the microwells by p-DEP by applying an alternating current voltage between the upper ITO and the lower microwell array electrode. The cells were retained inside the wells even after switching off the voltage and washing with a fluidic flow. Other myeloma cells stained in blue were then trapped in the microwells occupied by the cells stained in green to form the vertical cell pairing in the microwells. Cells stained in different colors were paired within only 1 min and a pairing efficiency of over 50% was achieved. PMID:24947270

  17. Effect of embedded optical fibres on the mechanical properties of cochlear electrode arrays.

    PubMed

    Carland, Emma M; Stoddart, Paul R; Cadusch, Peter J; Fallon, James B; Wade, Scott A

    2016-02-01

    Incorporating optical fibres in cochlear electrode arrays has been proposed to provide sensors to help minimise insertion trauma and also for the delivery of light in optical nerve stimulation applications. However, embedding an optical fibre into an electrode array may change its stiffness properties, which can affect the level of trauma during insertion. This report uses measurements of buckling and deflection force to compare the stiffness properties of a range of cochlear electrode arrays (Nucleus straight array, rat array, cat array and guinea pig array) with custom arrays containing an embedded optical fibre. The cladding diameters of the optical fibres tested were 125 µm, 80 µm and 50 µm. The results show that the stiffness of the optical-fibre-embedded arrays is related to the diameter of the optical fibre. Comparison with wired arrays suggests optical fibres with a diameter of 50 µm could be embedded into an electrode array without significantly changing the stiffness properties of the array. PMID:26776375

  18. Conical Gradient Junctions of Dendritic Viologen Arrays on Electrodes

    NASA Astrophysics Data System (ADS)

    Kawauchi, Takehiro; Oguchi, Yuki; Nagai, Keiji; Iyoda, Tomokazu

    2015-06-01

    The three-dimensional construction of arrays of functional molecules on an electrode surface, such as organic semiconductors and redox-active molecules, is a considerable challenge in the fabrication of sophisticated junctions for molecular devices. In particular, well-defined organic layers with precise molecular gradients are anticipated to function as novel metal/organic interfaces with specific electrical properties, such as a space charge layer at the metal/semiconductor interface. Here, we report a strategy for the construction of a three-dimensional molecular array with an electrical connection to a metal electrode by exploiting dendritic molecular architecture. Newly designed dendritic molecules consisting of viologens (1,1‧-disubstituted-4,4‧-bipyridilium salts) as the framework and mercapto groups as anchor units form unique self-assembled monolayers (SAMs) on a gold surface reflecting the molecular design. The dendritic molecules exhibit a conical shape and closely pack to form cone arrays on the substrate, whereas, in solution, they expand into more flexible conformations. Differences in the introduction position of the anchor units in the dendritic structure result in apical- and basal-type cone arrays in which the spatial concentration of the viologen units can be precisely configured in the cones. The concentration in apical-type SAMs increases away from the substrate, whereas the opposite is true in basal-type SAMs.

  19. Conical Gradient Junctions of Dendritic Viologen Arrays on Electrodes

    PubMed Central

    Kawauchi, Takehiro; Oguchi, Yuki; Nagai, Keiji; Iyoda, Tomokazu

    2015-01-01

    The three-dimensional construction of arrays of functional molecules on an electrode surface, such as organic semiconductors and redox-active molecules, is a considerable challenge in the fabrication of sophisticated junctions for molecular devices. In particular, well-defined organic layers with precise molecular gradients are anticipated to function as novel metal/organic interfaces with specific electrical properties, such as a space charge layer at the metal/semiconductor interface. Here, we report a strategy for the construction of a three-dimensional molecular array with an electrical connection to a metal electrode by exploiting dendritic molecular architecture. Newly designed dendritic molecules consisting of viologens (1,1′-disubstituted-4,4′-bipyridilium salts) as the framework and mercapto groups as anchor units form unique self-assembled monolayers (SAMs) on a gold surface reflecting the molecular design. The dendritic molecules exhibit a conical shape and closely pack to form cone arrays on the substrate, whereas, in solution, they expand into more flexible conformations. Differences in the introduction position of the anchor units in the dendritic structure result in apical- and basal-type cone arrays in which the spatial concentration of the viologen units can be precisely configured in the cones. The concentration in apical-type SAMs increases away from the substrate, whereas the opposite is true in basal-type SAMs. PMID:26057120

  20. Integrated Electrode Arrays for Neuro-Prosthetic Implants

    NASA Technical Reports Server (NTRS)

    Brandon, Erik; Mojarradi, Mohammede

    2003-01-01

    Arrays of electrodes integrated with chip-scale packages and silicon-based integrated circuits have been proposed for use as medical electronic implants, including neuro-prosthetic devices that might be implanted in brains of patients who suffer from strokes, spinal-cord injuries, or amyotrophic lateral sclerosis. The electrodes of such a device would pick up signals from neurons in the cerebral cortex, and the integrated circuit would perform acquisition and preprocessing of signal data. The output of the integrated circuit could be used to generate, for example, commands for a robotic arm. Electrode arrays capable of acquiring electrical signals from neurons already exist, but heretofore, there has been no convenient means to integrate these arrays with integrated-circuit chips. Such integration is needed in order to eliminate the need for the extensive cabling now used to pass neural signals to data-acquisition and -processing equipment outside the body. The proposed integration would enable progress toward neuro-prostheses that would be less restrictive of patients mobility. An array of electrodes would comprise a set of thin wires of suitable length and composition protruding from and supported by a fine-pitch micro-ball grid array or chip-scale package (see figure). The associated integrated circuit would be mounted on the package face opposite the probe face, using the solder bumps (the balls of the ball grid array) to make the electrical connections between the probes and the input terminals of the integrated circuit. The key innovation is the insertion of probe wires of the appropriate length and material into the solder bumps through a reflow process, thereby fixing the probes in place and electrically connecting them with the integrated circuit. The probes could be tailored to any distribution of lengths and made of any suitable metal that could be drawn into fine wires. Furthermore, the wires could be coated with an insulating layer using anodization or

  1. Nanoband array electrode as a platform for high sensitivity enzyme-based glucose biosensing.

    PubMed

    Falk, Magnus; Sultana, Reshma; Swann, Marcus J; Mount, Andrew R; Freeman, Neville J

    2016-12-01

    We describe a novel glucose biosensor based on a nanoband array electrode design, manufactured using standard semiconductor processing techniques, and bio-modified with glucose oxidase immobilized at the nanoband electrode surface. The nanoband array architecture allows for efficient diffusion of glucose and oxygen to the electrode, resulting in a thousand-fold improvement in sensitivity and wide linear range compared to a conventional electrode. The electrode constitutes a robust and manufacturable sensing platform. PMID:27118384

  2. Vertically aligned carbon nanofiber nanoelectrode arrays: electrochemical etching and electrode reusability

    PubMed Central

    Gupta, Rakesh K.; Meyyappan, M.; Koehne, Jessica E.

    2014-01-01

    Vertically aligned carbon nanofibers in the form of nanoelectrode arrays were grown on nine individual electrodes, arranged in a 3 × 3 array geometry, in a 2.5 cm2 chip. Electrochemical etching of the carbon nanofibers was employed for electrode activation and enhancing the electrode kinetics. Here, we report the effects of electrochemical etching on the fiber height and electrochemical properties. Electrode regeneration by amide hydrolysis and electrochemical etching is also investigated for electrode reusability. PMID:25089188

  3. Operation of a planar-electrode ion-trap array with adjustable RF electrodes

    NASA Astrophysics Data System (ADS)

    Kumph, M.; Holz, P.; Langer, K.; Meraner, M.; Niedermayr, M.; Brownnutt, M.; Blatt, R.

    2016-02-01

    One path to realizing systems of trapped atomic ions suitable for large-scale quantum computing and simulation is to create a two-dimensional (2D) array of ion traps. Interactions between nearest-neighbouring ions could then be turned on and off by tuning the ions’ relative positions and frequencies. We demonstrate and characterize the operation of a planar-electrode ion-trap array. By driving the trap with a network of phase-locked radio-frequency resonators which provide independently variable voltage amplitudes we vary the position and motional frequency of a Ca+ ion in two-dimensions within the trap array. Work on fabricating a miniaturised form of this 2D trap array is also described, which could ultimately provide a viable architecture for large-scale quantum simulations.

  4. Electrochemical Patterning and Detection of DNA Arrays on a Two-Electrode Platform

    PubMed Central

    Furst, Ariel; Landefeld, Sally; Hill, Michael G.; Barton, Jacqueline K.

    2014-01-01

    We report a novel method of DNA array formation that is electrochemically formed and addressed with a two-electrode platform. Electrochemical activation of a copper catalyst, patterned with one electrode, enables precise placement of multiple sequences of DNA onto a second electrode surface. The two-electrode patterning and detection platform allows for both spatial resolution of the patterned DNA array and optimization of detection through DNA-mediated charge transport with electrocatalysis. This two-electrode platform has been used to form arrays that enable differentiation between well-matched and mismatched sequences, the detection of TATA-binding protein, and sequence-selective DNA hybridization. PMID:24328227

  5. Electrochemical patterning and detection of DNA arrays on a two-electrode platform.

    PubMed

    Furst, Ariel; Landefeld, Sally; Hill, Michael G; Barton, Jacqueline K

    2013-12-26

    We report a novel method of DNA array formation that is electrochemically formed and addressed with a two-electrode platform. Electrochemical activation of a copper catalyst, patterned with one electrode, enables precise placement of multiple sequences of DNA onto a second electrode surface. The two-electrode patterning and detection platform allows for both spatial resolution of the patterned DNA array and optimization of detection through DNA-mediated charge transport with electrocatalysis. This two-electrode platform has been used to form arrays that enable differentiation between well-matched and mismatched sequences, the detection of TATA-binding protein, and sequence-selective DNA hybridization. PMID:24328227

  6. Optoacoustic spectroscopic imaging of radiolucent foreign bodies

    NASA Astrophysics Data System (ADS)

    Page, Leland; Maswadi, Saher; Glickman, Randolph D.

    2010-03-01

    One of the leading causes of medical malpractice claims in emergency medicine is the misdiagnosis of the presence of foreign bodies. Radiolucent foreign bodies are especially difficult to differentiate from surrounding soft tissue, gas, and bone. Current imaging modalities employed for the detection of foreign bodies include: X-ray computed tomography, magnetic resonance, and ultrasound; however, there is no consensus as to which modality is optimal for diagnosis. Because many radiolucent foreign bodies have sufficient contrast for imaging in the optical domain, we are exploring the use of laser-induced optoacoustic imaging for the detection of foreign bodies, especially in craniofacial injuries, in which the foreign bodies are likely to lie within the penetration depth of visible and near infrared wavelengths. Tissue-simulating phantoms containing various common foreign bodies have been constructed. Images of these phantoms have been successfully generated using two laser-based optoacoustic imaging methods with different detection modalities. In order to enhance the image contrast, common foreign bodies are being scanned over a wide range of wavelengths to obtain the spectroscopic properties of the materials commonly associated with these foreign bodies. This spectroscopic characterization will help select specific wavelengths to be used for imaging specific objects and provide useful diagnostic data about the material properties of the object.

  7. Electrical breakdown gas detector featuring carbon nanotube array electrodes.

    PubMed

    Kim, Seongyul; Pal, Sunil; Ajayan, Pulickel M; Borca-Tasciuc, Theodorian; Koratkar, Nikhil

    2008-01-01

    We demonstrate here detection of dichloro-difluoro-methane and oxygen in mixtures with helium using a carbon nanotube electrical breakdown sensor device. The sensor is comprised of an aligned array of multiwalled carbon nanotubes deposited on a nickel based super-alloy (Inconel 600) as the anode; the counter electrode is a planar nickel sheet. By monitoring the electrical breakdown characteristics of oxygen and dichloro-difluoro-methane in a background of helium, we find that the detection limit for dichloro-difluoro-methane is approximately 0.1% and the corresponding limit for oxygen is approximately 1%. A phenomenologigal model is proposed to describe the trends observed in detection of the two mixtures. These results indicate that carbon nanotube based electrical breakdown sensors show potential as end detectors in gas-chromatography devices. PMID:18468093

  8. Digital microfluidic operations on micro-electrode dot array architecture.

    PubMed

    Wang, G; Teng, D; Fan, S-K

    2011-12-01

    As digital microfluidics-based biochips find more applications, their complexity is expected to increase significantly owing to the trend of multiple and concurrent assays on the chip. There is a pressing need to deliver a top-down design methodology that the biochip designer can leverage the same level of computer-aided design support as the semi-conductor industry now does. Moreover, as microelectronics fabrication technology is scaling up and integrated device performance is improving, it is expected that these microfluidic biochips will be integrated with microelectronic components in next-generation system-on-chip designs. This study presents the analysis and experiments of digital microfluidic operations on a novel electrowetting-on-dielectric-based 'micro-electrode dot array architecture' that fosters a development path for hierarchical top-down design approach for digital microfluidics. The proposed architecture allows dynamic configurations and activations of identical basic microfluidic unit called 'micro-electrode cells' to design microfluidic components, layouts, routing, microfluidic operations and applications of the biochip hierarchically. Fundamental microfluidic operations have been successfully performed by the architecture. In addition, this novel architecture demonstrates a number of advantages and flexibilities over the conventional digital microfluidics in performing advanced microfluidic operations. PMID:22149873

  9. Design and characterisation of a thin-film electrode array with shared reference/counter electrodes for electrochemical detection.

    PubMed

    Uludag, Yildiz; Olcer, Zehra; Sagiroglu, Mahmut Samil

    2014-07-15

    In the current study, a novel electrode array and integrated microfluidics have been designed and characterised in order to create a sensor chip which is not only easy, rapid and cheaper to produce but also have a smaller imprint and good electrochemical sensing properties. The current study includes the assessment of the effects of an Au quasi-reference electrode and the use of shared reference/counter electrodes for the array, in order to obtain a small array that can be produced using a fine metal mask. In the study, it is found that when Au is used as the quasi-reference electrode, the arrays with shared reference and counter electrodes result in faster electron transfer kinetics and prevent the potential change with respect to scan rate, and hence is advantageous with respect to conventional electrodes. In addition, the resulting novel electrode array has been shown to result in higher current density (10.52 µA/cm(2); HRP detection assay) and measured diffusion coefficient (14.40×10(-12) cm(2)/s; calculated from the data of cyclic voltammetry with 1mM potassium ferricyanide) with respect to conventional electrodes tested in the study. Using the new electrode arrays, the detection limits obtained from horse radish peroxidase (HRP) and bisphenol A assays were 12.5 ng/ml (2.84×10(-10) M ) and 10 ng/ml (44×10(-9) M), respectively. Performing the HRP detection assay in a flow injection system using array integrated microfluidics provided 25 times lower detection limit (11.36×10(-12) M), although Ti has been used as electrode material instead of Au. In short, incorporation of this new electrode array to lab-on-a-chip or MEMs (micro-electro mechanic systems) technologies may pave the way for easy to use automated biosensing devices that could be used for a variety of applications from diagnostics to environmental monitoring, and studies will continue to move forward in this direction. PMID:24561521

  10. Mapping the temporal pole with a specialized electrode array: technique and preliminary results

    PubMed Central

    Abel, Taylor J.; Rhone, Ariane E.; Nourski, Kirill V.; Granner, Mark A.; Oya, Hiroyuki; Griffiths, Timothy D.; Tranel, Daniel T.; Kawasaki, Hiroto; Howard, Matthew A.

    2014-01-01

    Temporopolar cortex plays a crucial role in the pathogenesis of temporal lobe epilepsy and subserves important cognitive functions. Because of its shape and position in the middle cranial fossa, complete electrode coverage of the temporal pole (TP) is difficult to achieve using existing devices. We designed a novel TP electrode array that conforms to the surface of temporopolar cortex and achieves dense electrode coverage of this important brain region. A multi-pronged electrode array was designed that can be placed over the surface of the TP using a straightforward insertion technique. Twelve patients with medically intractable epilepsy were implanted with the TP electrode array for purposes of seizure localization. Select patients underwent cognitive mapping by electrocorticographic (ECoG) recording from the TP during a naming task. Use of the array resulted in excellent TP electrode coverage in all patients. High quality ECoG data were consistently obtained for purposes of delineating seizure activity and functional mapping. During a naming task, significant increases in ECoG power were observed within localized subregions of the TP. One patient developed a transient neurological deficit thought to be related to the mass effect of multiple intracranial recording arrays, including the TP array. This deficit resolved following removal of all electrodes. The TP electrode array overcomes limitations of existing devices and enables clinicians and researchers to obtain optimal multi-site recordings from this important brain region. PMID:24480831

  11. Integrated wireless neural interface based on the Utah electrode array.

    PubMed

    Kim, S; Bhandari, R; Klein, M; Negi, S; Rieth, L; Tathireddy, P; Toepper, M; Oppermann, H; Solzbacher, F

    2009-04-01

    This report presents results from research towards a fully integrated, wireless neural interface consisting of a 100-channel microelectrode array, a custom-designed signal processing and telemetry IC, an inductive power receiving coil, and SMD capacitors. An integration concept for such a device was developed, and the materials and methods used to implement this concept were investigated. We developed a multi-level hybrid assembly process that used the Utah Electrode Array (UEA) as a circuit board. The signal processing IC was flip-chip bonded to the UEA using Au/Sn reflow soldering, and included amplifiers for up to 100 channels, signal processing units, an RF transmitter, and a power receiving and clock recovery module. An under bump metallization (UBM) using potentially biocompatible materials was developed and optimized, which consisted of a sputter deposited Ti/Pt/Au thin film stack with layer thicknesses of 50/150/150 nm, respectively. After flip-chip bonding, an underfiller was applied between the IC and the UEA to improve mechanical stability and prevent fluid ingress in in vivo conditions. A planar power receiving coil fabricated by patterning electroplated gold films on polyimide substrates was connected to the IC by using a custom metallized ceramic spacer and SnCu reflow soldering. The SnCu soldering was also used to assemble SMD capacitors on the UEA. The mechanical properties and stability of the optimized interconnections between the UEA and the IC and SMD components were measured. Measurements included the tape tests to evaluate UBM adhesion, shear testing between the Au/Sn solder bumps and the substrate, and accelerated lifetime testing of the long-term stability for the underfiller material coated with a a-SiC(x):H by PECVD, which was intended as a device encapsulation layer. The materials and processes used to generate the integrated neural interface device were found to yield a robust and reliable integrated package. PMID:19067174

  12. USE OF COUPLED MULTI-ELECTRODE ARRAYS TO ADVANCE THE UNDERSTANDING OF SELECTED CORROSION PHENOMENA

    SciTech Connect

    N.D. Budiansky; F. Bocher; H. Cong; M.F. Hurley; J.R. Scully

    2006-02-23

    The use of multi-coupled electrode arrays in various corrosion applications is discussed with the main goal of advancing the understanding of various corrosion phenomena. Both close packed and far spaced electrode configurations are discussed. Far spaced electrode arrays are optimized for high throughput experiments capable of elucidating the effects of various variables on corrosion properties. For instance the effects of a statistical distribution of flaws on corrosion properties can be examined. Close packed arrays enable unprecedented spatial and temporal information on the behavior of local anodes and cathodes. Interactions between corrosion sites can trigger or inhibit corrosion phenomena and affect corrosion damage evolution.

  13. Improved 2-D resistivity imaging of features in covered karst terrain with arrays of implanted electrodes

    NASA Astrophysics Data System (ADS)

    Kiflu, H. G.; Kruse, S. E.; Harro, D.; Loke, M. H.; Wilkinson, P. B.

    2013-12-01

    Electrical resistivity tomography is commonly used to identify geologic features associated with sinkhole formation. In covered karst terrain, however, it can be difficult to resolve the depth to top of limestone with this method. This is due to the fact that array lengths, and hence depth of resolution, are often limited by residential or commercial lot dimensions in urban environments. Furthermore, the sediments mantling the limestone are often clay-rich and highly conductive. The resistivity method has limited sensitivity to resistive zones beneath conductive zones. This sensitivity can be improved significantly with electrodes implanted at depth in the cover sediments near the top of limestone. An array of deep electrodes is installed with direct push technology in the karst cover. When combined with a surface array in which each surface electrode is underlain by a deep electrode, the array geometry is similar to a borehole array turned on its side. This method, called the Multi-Electrode Resistivity Implant Technique (MERIT), offers the promise of significantly improved resolution of epikarst and cover collapse development zones in the overlying sediment, the limestone or at the sediment-bedrock interface in heterogeneous karst environments. With a non-traditional array design, the question of optimal array geometries arises. Optimizing array geometries is complicated by the fact that many plausible 4-electrode readings will produce negative apparent resistivity values, even in homogeneous terrain. Negative apparent resistivities cannot be used in inversions based on the logarithm of the apparent resistivity. New algorithms for seeking optimal array geometries have been developed by modifying the 'Compare R' method of Wilkinson and Loke. The optimized arrays show significantly improved resolution over basic arrays adapted from traditional 2D surface geometries. Several MERIT case study surveys have been conducted in covered karst in west-central Florida, with

  14. Using multivariate analyses to compare subsets of electrodes and potentials within an electrode array for predicting sugar concentrations in mixed solutions.

    SciTech Connect

    Stork, Christopher Lyle; Steen, William Arthur

    2008-04-01

    A non-selective electrode array is presented for the quantification of fructose, galactose, and glucose in mixed solutions. A unique feature of this electrode array relative to other published work is the wide diversity of electrode materials incorporated within the array, being constructed of 41 different metals and metal alloys. Cyclic voltammograms were acquired for solutions containing a single sugar at varying concentrations, and the correlation between current and sugar concentration was calculated as a function of potential and electrode array element. The correlation plots identified potential regions and electrodes that scaled most linearly with sugar concentration, and the number of electrodes used in building predictive models was reduced to 15. Partial least squares regression models relating electrochemical response to sugar concentration were constructed using data from single electrodes and multiple electrodes within the array, and the predictive abilities of these models were rigorously compared using a non-parametric Wilcoxon test. Models using single electrodes (Pt:Rh (90:10) for fructose, Au:Ni (82:18) for galactose, and Au for glucose) were judged to be statistically superior or indistinguishable from those built with multiple electrodes. Additionally, for each sugar, interval partial least squares regression successfully identified a subset of potentials within a given electrode that generated a model of statistically equivalent predictive ability relative to the full potential model. While including data from multiple electrodes offered no benefit in predicting sugar concentration, use of the array afforded the versatility and flexibility of selecting the best single electrode for each sugar.

  15. Multiple Radiolucencies of the Jaws in a 6 Year Old.

    PubMed

    Hansford, John T; Kelsch, Robert D; Wiltz, Mauricio

    2015-11-01

    Radiolucencies of the jaws are a common finding. Mostly, they are isolated findings associated with inflammatory processes and consistent with inflammatory periapical disease, such as periapical cysts and periapical granulomas. If associated with the crowns of unerupted teeth, they may represent dentigerous cysts. However, occasionally, larger lytic/radiolucent lesions are identified; even more infrequently, these radiographic findings may be multiple and concurrent. The purpose of this report is to present the case of a 6-year-old female patient with no known concomitant syndrome who presented with multiple intraoral swellings and to discuss the treatment of multiple, bilateral mandibular and maxillary radiolucencies. PMID:26749783

  16. Improved spike sorting for multi-electrode array data from mammalian retina

    NASA Astrophysics Data System (ADS)

    Prentice, Jason; Homann, Jan; Simmons, Kristy; Tkacik, Gasper; Balasubramanian, Vijay; Nelson, Philip

    2010-03-01

    Multi-electrode array technology provides an efficient means of simultaneously recording from many neurons. However, as arrays become larger, a greater computational burden falls on the spike-sorting algorithm. We have developed a new method for sorting multi-electrode signals and applied it to retinal ganglion cells. Our method is explicitly designed to scale well with increasing array size. It can dissect temporally overlapping spikes and accommodate the amplitude variation seen in spike bursts. The broad outline of our method is to (1) identify spikes in the raw data, cluster a subset, generate template waveforms, then (2) fit the templates to all the data using an iterative Bayesian algorithm. Each of these two steps makes use of the 2D spatial arrangement of the ganglion cells and electrodes, and the locality of signals from each individual cell. We demonstrate the method on data recorded from guinea pig retina on a 30-electrode array.

  17. Synchronization of neurons in micro-electrode array cultures

    NASA Astrophysics Data System (ADS)

    Esposti, F.; Signorini, M. G.

    2008-12-01

    A lot of methods were created in last decade for the spatio-temporal analysis of multi-electrode array (MEA) neuronal data sets. In this paper we show how a new simple analysis approach that considers the total network activity, is able to show interesting neuronal network system dynamical features. In particular, we perform two different analyses: a neuronal connectivity examination studying networks at different days in vitro (div) and an analysis of the long per- iod effects of the administration of two common neuroactive drugs, Tetrodotoxin (TTX) and D-2-amino-5-phosphonovalerate (AP5), to spontaneously spiking mature neuronal networks. Our analysis is performed considering burst topology, i.e., cataloguing network bursts as Global (if they involve more than the 25% of the MEA channels) or Local (if less that 25%). In the first analysis, this division allows to understand the network connectivity developments. The networking increases from div 1 to 6 building up an undifferentiated highly connected network. From div 6 to 10 the networking decreases (pruning) till reaching a plateau in a small-world like organization. The second analysis highlights substantial differences between long period effects of TTX and AP5. Results show that AP5, selectively blocking NMDA receptors and inhibiting long term potentiation, is unable to produce activity twisting in a network that already reached a developmental plateau, but it is able to desynchronize sub-network (Local) activity. TTX, on the other side, blocking any type of electrical communication among neurons, acts on the whole network synchronization. The important activity increment in the post-TTX epoch (+66%), together with the Global activity explosion, suggests the possibility of a long-term inhibitory-synapse depression mechanism.

  18. A Palladium-Tin Modified Microband Electrode Array for Nitrate Determination

    PubMed Central

    Fu, Yexiang; Bian, Chao; Kuang, Jian; Wang, Jinfen; Tong, Jianhua; Xia, Shanhong

    2015-01-01

    A microband electrode array modified with palladium-tin bimetallic composite has been developed for nitrate determination. The microband electrode array was fabricated by Micro Electro-Mechanical System (MEMS) technique. Palladium and tin were electrodeposited successively on the electrode, forming a double-layer structure. The effect of the Pd-Sn composite was investigated and its enhancement of catalytic activity and lifetime was revealed. The Pd-Sn modified electrode showed good linearity (R2 = 0.998) from 1 mg/L to 20 mg/L for nitrate determination with a sensitivity of 398 μA/(mg∙L−1∙cm2). The electrode exhibited a satisfying analytical performance after 60 days of storage, indicating a long lifetime. Good repeatability was also displayed by the Pd-Sn modified electrodes. The results provided an option for nitrate determination in water. PMID:26389904

  19. A Palladium-Tin Modified Microband Electrode Array for Nitrate Determination.

    PubMed

    Fu, Yexiang; Bian, Chao; Kuang, Jian; Wang, Jinfen; Tong, Jianhua; Xia, Shanhong

    2015-01-01

    A microband electrode array modified with palladium-tin bimetallic composite has been developed for nitrate determination. The microband electrode array was fabricated by Micro Electro-Mechanical System (MEMS) technique. Palladium and tin were electrodeposited successively on the electrode, forming a double-layer structure. The effect of the Pd-Sn composite was investigated and its enhancement of catalytic activity and lifetime was revealed. The Pd-Sn modified electrode showed good linearity (R² = 0.998) from 1 mg/L to 20 mg/L for nitrate determination with a sensitivity of 398 μA/(mg∙L(-1)∙cm²). The electrode exhibited a satisfying analytical performance after 60 days of storage, indicating a long lifetime. Good repeatability was also displayed by the Pd-Sn modified electrodes. The results provided an option for nitrate determination in water. PMID:26389904

  20. Electrodeposition of gold nanoparticle arrays on ITO glass as electrode with high electrocatalytic activity

    SciTech Connect

    Zhang, Kui; Wei, Juan; Zhu, Houjuan; Ma, Fang; Wang, Suhua

    2013-03-15

    Highlights: ► Electrodeposition of gold nanoparticle arrays on ITO glass as catalytic-electrodes. ► The sizes and densities of the gold nanoparticles can be easily controlled. ► Such arrays on ITO glass shows high electrocatalytic activity and good stability. - Abstract: Herein, we reported a templateless, surfactantless, and simple electrochemical method to directly fabricate gold nanoparticle (AuNP) arrays on indium tin oxide (ITO) glass substrates as effective electrocatalytic electrodes. The as-prepared AuNP arrays have been characterized by scanning electron microscopy (SEM), X-ray photoelectron spectroscopy (XPS), X-ray diffraction (XRD), etc. AuNPs with small sizes (<20 nm) were uniformly deposited on the ITO glass under constant current densities, and particle densities can be adjusted by varying the applied charges. The resultant AuNP array electrode showed higher catalytic activity and good stability toward electro-oxidation of ascorbic acid compared with other electrodes, such as bare ITO electrode, bare glassy carbon electrode and bulk gold film electrode.

  1. Fabrication and evaluation of an improved polymer-based cochlear electrode array for atraumatic insertion.

    PubMed

    Gwon, Tae Mok; Min, Kyou Sik; Kim, Jin Ho; Oh, Seung Ha; Lee, Ho Sun; Park, Min-Hyun; Kim, Sung June

    2015-04-01

    An atraumatic cochlear electrode array has become indispensable to high-performance cochlear implants such as electric acoustic stimulation (EAS), wherein the preservation of residual hearing is significant. For an atraumatic implantation, we propose and demonstrate a new improved design of a cochlear electrode array based on liquid crystal polymer (LCP), which can be fabricated by precise batch processes and a thermal lamination process, in contrast to conventional wire-based cochlear electrode arrays. Using a thin-film process of LCP-film-mounted silicon wafer and thermal press lamination, we devise a multi-layered structure with variable layers of LCP films to achieve a sufficient degree of basal rigidity and a flexible tip. A peripheral blind via and self-aligned silicone elastomer molding process can reduce the width of the array. Measuring the insertion and extraction forces in a human scala tympani model, we investigate five human temporal bone insertion trials and record electrically evoked auditory brainstem responses (EABR) acutely in a guinea pig model. The diameters of the finalized electrode arrays are 0.3 mm (tip) and 0.75 mm (base). The insertion force with a displacement of 8 mm from a round window and the maximum extraction force are 2.4 mN and 34.0 mN, respectively. The electrode arrays can be inserted from 360° to 630° without trauma at the basal turn. The EABR data confirm the efficacy of the array. A new design of LCP-based cochlear electrode array for atraumatic implantation is fabricated. Verification indicates that foretells the development of an atraumatic cochlear electrode array and clinical implant. PMID:25681972

  2. An Ultralong, Highly Oriented Nickel-Nanowire-Array Electrode Scaffold for High-Performance Compressible Pseudocapacitors.

    PubMed

    Xu, Chao; Li, Ziheng; Yang, Cheng; Zou, Peichao; Xie, Binghe; Lin, Ziyin; Zhang, Zhexu; Li, Baohua; Kang, Feiyu; Wong, Ching-Ping

    2016-06-01

    Ultralong, highly oriented Ni nanowire arrays are used as the electrode scaffold to support metal-oxide- and conductive-polymer-based electrode materials with a high mass loading; the as-obtained asymmetric supercapacitor can be compressed by fourfold and exhibits superior energy and power densities with ultrahigh cycle stability. PMID:27062285

  3. Shaping of steel mold surface of lens array by electrical discharge machining with single rod electrode.

    PubMed

    Takino, Hideo; Hosaka, Takahiro

    2014-11-20

    We propose a method for fabricating a lens array mold by electrical discharge machining (EDM). In this method, the tips of rods are machined individually to form a specific surface, and then a number of the machined rods are arranged to construct an electrode for EDM. The repetition of the EDM process using the electrode enables a number of lens elements to be produced on the mold surface. The effectiveness of our proposed method is demonstrated by shaping a lens array mold made of stainless steel with 16 spherical elements, in which the EDM process with a single rod electrode is repeatedly conducted. PMID:25607880

  4. A Novel Method of Fabricating Convoluted Shaped Electrode Arrays for Neural and Retinal Prostheses

    PubMed Central

    Bhandari, R.; Negi, S.; Rieth, L.; Normann, R. A.; Solzbacher, F.

    2008-01-01

    A novel fabrication technique has been developed for creating high density (6.25 electrodes/mm2), out of plane, high aspect ratio silicon-based convoluted microelectrode arrays for neural and retinal prostheses. The convoluted shape of the surface defined by the tips of the electrodes could compliment the curved surfaces of peripheral nerves and the cortex, and in the case of retina, its spherical geometry. The geometry of these electrode arrays has the potential to facilitate implantation in the nerve fascicles and to physically stabilize it against displacement after insertion. This report presents a unique combination of variable depth dicing and wet isotropic etching for the fabrication of a variety of convoluted neural array geometries. Also, a method of deinsulating the electrode tips using photoresist as a mask and the limitations of this technique on uniformity are discussed. PMID:19122774

  5. A flexible microchannel electrode array for peripheral nerves to interface with neural prosthetics

    NASA Astrophysics Data System (ADS)

    Landrith, Ryan; Nothnagle, Caleb; Kim, Young-tae; Wijesundara, Muthu B. J.

    2016-05-01

    In order to control neural prosthetics by recording signals from peripheral nerves with the required specificity, high density electrode arrays that can be easily implanted on very small peripheral nerves (50μm-500μm) are needed. Interfacing with these small nerves is surgically challenging due to their size and fragile nature. To address this problem, a Flexible MicroChannel Electrode Array for interfacing with small diameter peripheral nerves and nerve fascicles was developed. The electrochemical characterization and electrophysiological recordings from the common peroneal nerve of a rat are presented along with demonstration of the surgical ease-of-use of the array.

  6. Mass transport at infinite regular arrays of microband electrodes submitted to natural convection: theory and experiments.

    PubMed

    Pebay, Cécile; Sella, Catherine; Thouin, Laurent; Amatore, Christian

    2013-12-17

    Mass transport at infinite regular arrays of microband electrodes was investigated theoretically and experimentally in unstirred solutions. Even in the absence of forced hydrodynamics, natural convection limits the convection-free domain up to which diffusion layers may expand. Hence, several regimes of mass transport may take place according to the electrode size, gap between electrodes, time scale of the experiment, and amplitude of natural convection. They were identified through simulation by establishing zone diagrams that allowed all relative contributions to mass transport to be delineated. Dynamic and steady-state regimes were compared to those achieved at single microband electrodes. These results were validated experimentally by monitoring the chronoamperometric responses of arrays with different ratios of electrode width to gap distance and by mapping steady-state concentration profiles above their surface through scanning electrochemical microscopy. PMID:24283775

  7. Shaping of steel mold surface of lens array by electrical discharge machining with spherical ball electrode.

    PubMed

    Takino, Hideo; Hosaka, Takahiro

    2016-06-20

    We propose a method for fabricating a spherical lens array mold by electrical discharge machining (EDM) with a ball-type electrode. The electrode is constructed by arranging conductive spherical balls in an array. To fundamentally examine the applicability of the proposed EDM method to the fabrication of lens array molds, we use an electrode having a single ball to shape a lens array mold made of stainless steel with 16 spherical elements, each having a maximum depth of 0.5 mm. As a result, a mold surface is successfully shaped with a peak-to-valley shape accuracy of approximately 10 μm, and an average surface roughness of 0.85 μm. PMID:27409126

  8. Simulating pad-electrodes with high-definition arrays in transcranial electric stimulation

    NASA Astrophysics Data System (ADS)

    Kempe, René; Huang, Yu; Parra, Lucas C.

    2014-04-01

    Objective. Research studies on transcranial electric stimulation, including direct current, often use a computational model to provide guidance on the placing of sponge-electrode pads. However, the expertise and computational resources needed for finite element modeling (FEM) make modeling impractical in a clinical setting. Our objective is to make the exploration of different electrode configurations accessible to practitioners. We provide an efficient tool to estimate current distributions for arbitrary pad configurations while obviating the need for complex simulation software. Approach. To efficiently estimate current distributions for arbitrary pad configurations we propose to simulate pads with an array of high-definition (HD) electrodes and use an efficient linear superposition to then quickly evaluate different electrode configurations. Main results. Numerical results on ten different pad configurations on a normal individual show that electric field intensity simulated with the sampled array deviates from the solutions with pads by only 5% and the locations of peak magnitude fields have a 94% overlap when using a dense array of 336 electrodes. Significance. Computationally intensive FEM modeling of the HD array needs to be performed only once, perhaps on a set of standard heads that can be made available to multiple users. The present results confirm that by using these models one can now quickly and accurately explore and select pad-electrode montages to match a particular clinical need.

  9. A MEMS fabricated flexible electrode array for recording surface field potentials.

    PubMed

    Hollenberg, Brian A; Richards, Cecilia D; Richards, Robert; Bahr, David F; Rector, David M

    2006-05-15

    We developed a method to microfabricate flexible electrode arrays on a thin Kapton substrate, which was engineered to minimize trauma when inserted between the dura and skull to obtain surface EEG recordings. The array consisted of 64 gold electrodes, each 150microm in diameter on a 750microm spaced 8x8 grid. Using photolithographic procedures, any arrangement of electrodes can be implemented. We used the electrode array to record evoked response signals to create topographical maps of the whisker barrels on the cortical surface with excellent signal stability over a period of 8h. The materials used for this fabrication are potentially biologically inert and, with some additional modifications to the design, can be chronically implanted with minimal side effects. Retinal prosthesis, human neurosurgery, and neurological research are all limited to some degree by the resolution and biological compatibility of the implants used. This type of array could greatly enhance the spatial resolution, signal quality, and stability of implantable surface electrode arrays. PMID:16352343

  10. Characterization of flexible ECoG electrode arrays for chronic recording in awake rats

    PubMed Central

    Yeager, John D.; Phillips, Derrick J.; Rector, David M.; Bahr, David F.

    2008-01-01

    We developed a 64 channel flexible polyimide ECoG electrode array and characterized its performance for long term implantation, chronic cortical recording and high resolution mapping of surface evoked potentials in awake rats. To achieve the longest possible recording periods, the flexibility of the electrode array, adhesion between the metals and carrier substrate, and biocompatibility was critical for maintaining the signal integrity. Experimental testing of thin film adhesion was applied to a gold – polyimide system in order to characterize relative interfacial fracture energies for several different adhesion layers, yielding an increase in overall device reliability. We tested several different adhesion techniques including: gold alone without an adhesion layer, titanium-tungsten, tantalum and chromium. We found the titanium-tungsten to be a suitable adhesion layer considering the biocompatibility requirements as well as stability and delamination resistance. While chromium and tantalum produced stronger gold adhesion, concerns over biocompatibility of these materials require further testing. We implanted the polyimide ECoG electrode arrays through a slit made in the skull of rats and recorded cortical surface evoked responses. The arrays performed reliably over a period of at least 100 days and signals compared well with traditional screw electrodes, with better high frequency response characteristics. Since the ultimate goal of chronically implanted electrode arrays is for neural prosthetic devices that need to last many decades, other adhesion layers that would prove safe for implantation may be tested in the same way in order to improve the device reliability. PMID:18640155

  11. Cochleotopic selectivity of a multichannel scala tympani electrode array using the 2-deoxyglucose technique.

    PubMed

    Brown, M; Shepherd, R K; Webster, W R; Martin, R L; Clark, G M

    1992-05-01

    The 2-deoxyglucose (2-DG) technique was used to study the cochleotopic selectivity of a multichannel scala tympani electrode array in four cats with another acting as an unstimulated control. Each animal was unilaterally deafened and a multichannel electrode array inserted 6 mm into the scala tympani. Thresholds to electrical stimulation were determined by recording electrically evoked auditory brainstem responses (EABRs). Each animal was injected with 2-DG, and electrically stimulated using bipolar electrodes located either distal or proximal to the round window. The contralateral ear was stimulated with acoustic tone pips at frequencies that matched the electrode place. Stimulation of both distal and proximal bipolar electrodes at 3 x EABR threshold, evoked localized 2-DG labelling in both ipsilateral cochlear nucleus (CN) and the contralateral inferior colliculus (IC), which was very similar in orientation and breadth to labelling evoked by the contralateral tone pips. The cochleotopic position of labelling to proximal stimulation was located in the 24-26 kHz region of each structure, whereas the distal labelling was located around 12 kHz. Distal stimulation at 10 x EABR threshold produced very broad 2-DG labelling in IC centered around the 12 kHz place. The present 2-DG results clearly illustrate cochleotopic selectivity using multichannel bipolar scala tympani electrodes. The extent of this selectivity is dependent on electrical stimulus levels. The 2-DG technique has great potential in evaluating the efficacy of new electrode array designs. PMID:1618713

  12. Optimized arrays for 2-D resistivity survey lines with a large number of electrodes

    NASA Astrophysics Data System (ADS)

    Loke, M. H.; Wilkinson, P. B.; Chambers, J. E.; Uhlemann, S. S.; Sorensen, J. P. R.

    2015-01-01

    Previous studies show that optimized arrays generated using the 'Compare R' method have significantly better resolution than conventional arrays. This method determines the optimum set of arrays by selecting those that give the maximum model resolution. The number of possible arrays (the comprehensive data set) increases with the fourth power of the number of electrodes. The optimization method faces practical limitations for 2-D survey lines with more than 60 electrodes where the number of possible arrays exceeds a million. Several techniques are proposed to reduce the calculation time for such survey lines. A single-precision version of the 'Compare R' algorithm using a new ranking function reduces the calculation time by two to eight times while providing results similar to the double-precision version. Recent improvements in computer GPU technology can reduce the calculation time by about seven times. The calculation time is reduced by half by using the fact that arrays that are symmetrical about the center of the line produce identical changes in the model resolution values. It is further reduced by more than thirty times by calculating the Sherman-Morrison update for all the possible two-electrode combinations, which are then used to calculate the model resolution values for the four-electrode arrays. The calculation time is reduced by more then ten times by using a subset of the comprehensive data set consisting of only symmetrical arrays. Tests with a synthetic model and field data set show that optimized arrays derived from this subset produce inversion models with differences of less than 10% from those derived using the full comprehensive data set. The optimized data sets produced models that are more accurate than the Wenner-Schlumberger array data sets in all the tests.

  13. Chronic intracortical microstimulation (ICMS) of cat sensory cortex using the Utah Intracortical Electrode Array.

    PubMed

    Rousche, P J; Normann, R A

    1999-03-01

    In an effort to assess the safety and efficacy of focal intracortical microstimulation (ICMS) of cerebral cortex with an array of penetrating electrodes as might be applied to a neuroprosthetic device to aid the deaf or blind, we have chronically implanted three trained cats in primary auditory cortex with the 100-electrode Utah Intracortical Electrode Array (UIEA). Eleven of the 100 electrodes were hard-wired to a percutaneous connector for chronic access. Prior to implant, cats were trained to "lever-press" in response to pure tone auditory stimulation. After implant, this behavior was transferred to "lever-presses" in response to current injections via single electrodes of the implanted arrays. Psychometric function curves relating injected charge level to the probability of response were obtained for stimulation of 22 separate electrodes in the three implanted cats. The average threshold charge/phase required for electrical stimulus detection in each cat was, 8.5, 8.6, and 11.6 nC/phase respectively, with a maximum charge/phase of 26 nC/phase and a minimum of 1.5 nC/phase thresholds were tracked for varying time intervals, and seven electrodes from two cats were tracked for up to 100 days. Electrodes were stimulated for no more than a few minutes each day. Neural recordings taken from the same electrodes before and after multiple electrical stimulation sessions were very similar in signal/noise ratio and in the number of recordable units, suggesting that the range of electrical stimulation levels used did not damage neurons in the vicinity of the electrodes. Although a few early implants failed, we conclude that ICMS of cerebral cortex to evoke a behavioral response can be achieved with the penetrating UIEA. Further experiments in support of a sensory cortical prosthesis based on ICMS are warranted. PMID:10188608

  14. Advancements in electrode design and laser techniques for fabricating micro-electrode arrays as part of a retinal prosthesis.

    PubMed

    Dodds, C W D; Schuettler, M; Guenther, T; Lovell, N H; Suaning, G J

    2011-01-01

    Retinal micro-electrode arrays (MEAs) for a visual prosthesis were fabricated by laser structuring of platinum (Pt) foil and liquid silicone rubber. A new design was created using a folding technique to create a multi-layered array from a single Pt sheet. This method allowed a reduction in both the electrode pitch, and the overall width of the array, while maintaining coplanar connection points for more stable interconnections to other components of the system. The design also included a section which could be rolled to create a cylindrical segment in order to minimise the size of the exit in the sclera after implantation. A picosecond mode-locked 532 nm laser system was investigated as a replacement for the nanosecond Q-switched 1064 nm laser currently in use. Trials showed that the ps system could produce high quality electrode tracks with a minimum pitch of 30 μm, less than 40% the pitch achievable with the ns laser. A method was investigated for the cutting of Pt foils without damaging the underlying silicone by laser machining to a depth just below the thickness of the foil. Initial samples showed promise with full penetration of the foil only occurring at cross points of the laser paths. The ps laser was also used to create roughened surfaces, in order to increase the electrochemical surface area of the electrodes. Surfaces were imaged using a scanning electron microscope, and compared to surfaces roughened with the ns laser. The ps laser was seen to offer a reduction in feature size, as well as an increase in control over the appearance of the electrode surface. PMID:22254389

  15. An Electrode Array for Limiting Blood Loss During Liver Resection: Optimization via Mathematical Modeling

    PubMed Central

    Strigel, R.M.; Schutt, D.J.; Webster, J.G.; Mahvi, D.M.; Haemmerich, D.

    2010-01-01

    Liver resection is the current standard treatment for patients with both primary and metastatic liver cancer. The principal causes of morbidity and mortality after liver resection are related to blood loss (typically between 0.5 and 1 L), especially in cases where transfusion is required. Blood transfusions have been correlated with decreased long-term survival, increased risk of perioperative mortality and complications. The goal of this study was to evaluate different designs of a radiofrequency (RF) electrode array for use during liver resection. The purpose of this electrode array is to coagulate a slice of tissue including large vessels before resecting along that plane, thereby significantly reducing blood loss. Finite Element Method models were created to evaluate monopolar and bipolar power application, needle and blade shaped electrodes, as well as different electrode distances. Electric current density, temperature distribution, and coagulation zone sizes were measured. The best performance was achieved with a design of blade shaped electrodes (5 × 0.1 mm cross section) spaced 1.5 cm apart. The electrodes have power applied in bipolar mode to two adjacent electrodes, then switched sequentially in short intervals between electrode pairs to rapidly heat the tissue slice. This device produces a ~1.5 cm wide coagulation zone, with temperatures over 97 ºC throughout the tissue slice within 3 min, and may facilitate coagulation of large vessels. PMID:20309395

  16. Stacked 3D RRAM Array with Graphene/CNT as Edge Electrodes.

    PubMed

    Bai, Yue; Wu, Huaqiang; Wang, Kun; Wu, Riga; Song, Lin; Li, Tianyi; Wang, Jiangtao; Yu, Zhiping; Qian, He

    2015-01-01

    There are two critical challenges which determine the array density of 3D RRAM: 1) the scaling limit in both horizontal and vertical directions; 2) the integration of selector devices in 3D structure. In this work, we present a novel 3D RRAM structure using low-dimensional materials, including 2D graphene and 1D carbon nanotube (CNT), as the edge electrodes. A two-layer 3D RRAM with monolayer graphene as edge electrode is demonstrated. The electrical results reveal that the RRAM devices could switch normally with this very thin edge electrode at nanometer scale. Meanwhile, benefited from the asymmetric carrier transport induced by Schottky barrier at metal/CNT and oxide/CNT interfaces, a selector built-in 3D RRAM structure using CNT as edge electrode is successfully fabricated and characterized. Furthermore, the discussion of high array density potential is presented. PMID:26348797

  17. Stacked 3D RRAM Array with Graphene/CNT as Edge Electrodes

    PubMed Central

    Bai, Yue; Wu, Huaqiang; Wang, Kun; Wu, Riga; Song, Lin; Li, Tianyi; Wang, Jiangtao; Yu, Zhiping; Qian, He

    2015-01-01

    There are two critical challenges which determine the array density of 3D RRAM: 1) the scaling limit in both horizontal and vertical directions; 2) the integration of selector devices in 3D structure. In this work, we present a novel 3D RRAM structure using low-dimensional materials, including 2D graphene and 1D carbon nanotube (CNT), as the edge electrodes. A two-layer 3D RRAM with monolayer graphene as edge electrode is demonstrated. The electrical results reveal that the RRAM devices could switch normally with this very thin edge electrode at nanometer scale. Meanwhile, benefited from the asymmetric carrier transport induced by Schottky barrier at metal/CNT and oxide/CNT interfaces, a selector built-in 3D RRAM structure using CNT as edge electrode is successfully fabricated and characterized. Furthermore, the discussion of high array density potential is presented. PMID:26348797

  18. Three-dimensional micro-electrode array for recording dissociated neuronal cultures.

    PubMed

    Musick, Katherine; Khatami, David; Wheeler, Bruce C

    2009-07-21

    This work demonstrates the design, fabrication, packaging, characterization, and functionality of an electrically and fluidically active three-dimensional micro-electrode array (3D MEA) for use with neuronal cell cultures. The successful function of the device implies that this basic concept-construction of a 3D array with a layered approach-can be utilized as the basis for a new family of neural electrode arrays. The 3D MEA prototype consists of a stack of individually patterned thin films that form a cell chamber conducive to maintaining and recording the electrical activity of a long-term three-dimensional network of rat cortical neurons. Silicon electrode layers contain a polymer grid for neural branching, growth, and network formation. Along the walls of these electrode layers lie exposed gold electrodes which permit recording and stimulation of the neuronal electrical activity. Silicone elastomer micro-fluidic layers provide a means for loading dissociated neurons into the structure and serve as the artificial vasculature for nutrient supply and aeration. The fluidic layers also serve as insulation for the micro-electrodes. Cells have been shown to survive in the 3D MEA for up to 28 days, with spontaneous and evoked electrical recordings performed in that time. The micro-fluidic capability was demonstrated by flowing in the drug tetrotodoxin to influence the activity of the culture. PMID:19568672

  19. Orthogonal electrode catheter array for mapping of endocardial focal site of ventricular activation

    SciTech Connect

    Desai, J.M.; Nyo, H.; Vera, Z.; Seibert, J.A.; Vogelsang, P.J. )

    1991-04-01

    Precise location of the endocardial site of origin of ventricular tachycardia may facilitate surgical and catheter ablation of this arrhythmia. The endocardial catheter mapping technique can locate the site of ventricular tachycardia within 4-8 cm2 of the earliest site recorded by the catheter. This report describes an orthogonal electrode catheter array (OECA) for mapping and radiofrequency ablation (RFA) of endocardial focal site of origin of a plunge electrode paced model of ventricular activation in dogs. The OECA is an 8 F five pole catheter with four peripheral electrodes and one central electrode (total surface area 0.8 cm{sup 2}). In eight mongrel dogs, mapping was performed by arbitrarily dividing the left ventricle (LV) into four segments. Each segment was mapped with OECA to find the earliest segment. Bipolar and unipolar electrograms were obtained. The plunge electrode (not visible on fluoroscopy) site was identified by the earliest wave front arrival times of -30 msec or earlier at two or more electrodes (unipolar electrograms) with reference to the earliest recorded surface ECG (I, AVF, and V1). Validation of the proximity of the five electrodes of the OECA to the plunge electrode was performed by digital radiography and RFA. Pathological examination was performed to document the proximity of the OECA to the plunge electrode and also for the width, depth, and microscopic changes of the ablation. To find the segment with the earliest LV activation a total of 10 {plus minus} 3 (mean {plus minus} SD) positions were mapped. Mean arrival times at the two earlier electrodes were -39 {plus minus} 4 msec and -35 {plus minus} 3 msec. Digital radiography showed the plunge electrode to be within the area covered by all five electrodes in all eight dogs. The plunge electrode was within 1 cm2 area of the region of RFA in all eight dogs.

  20. Microfabrication of electrode patterns for high-frequency ultrasound transducer arrays.

    PubMed

    Bernassau, Anne L; García-Gancedo, Luis; Hutson, David; Démoré, Christine E M; McAneny, Jim J; Button, Tim W; Cochran, Sandy

    2012-08-01

    High-frequency ultrasound is needed for medical imaging with high spatial resolution. A key issue in the development of ultrasound imaging arrays to operate at high frequencies (≥30 MHz) is the need for photolithographic patterning of array electrodes. To achieve this directly on 1-3 piezocomposite, the material requires not only planar, parallel, and smooth surfaces, but also an epoxy composite filler that is resistant to chemicals, heat, and vacuum. This paper reports, first, on the surface finishing of 1-3 piezocomposite materials by lapping and polishing. Excellent surface flatness has been obtained, with an average surface roughness of materials as low as 3 nm and step heights between ceramic/polymer of ∼80 nm. Subsequently, high-frequency array elements were patterned directly on top of these surfaces using a photolithography process. A 30-MHz linear array electrode pattern with 50-μm element pitch has been patterned on the lapped and polished surface of a high-frequency 1-3 piezocomposite. Excellent electrode edge definition and electrical contact to the composite were obtained. The composite has been lapped to a final thickness of ∼55 μm. Good adhesion of electrodes on the piezocomposite has been achieved and electrical impedance measurements have demonstrated their basic functionality. The array was then packaged, and acoustic pulse-echo measurements were performed. These results demonstrate that direct patterning of electrodes by photolithography on 1-3 piezocomposite is feasible for fabrication of high-frequency ultrasound arrays. Furthermore, this method is more conducive to mass production than other reported array fabrication techniques. PMID:22899129

  1. Arrayed liquid crystal microlens based on graphene electrode for imaging application

    NASA Astrophysics Data System (ADS)

    Hu, Wei; Chen, Cheng; Wu, Yong; Luo, Jun; Lei, Yu; Tong, Qing; Zhang, Xinyu; Xie, Changsheng

    2015-10-01

    In this paper, an arrayed liquid crystal (LC) microlens (ALCM) based on graphene electrode instead of common indium tin oxide (ITO) electrode material is designed and fabricated, and the corresponding testing results have been obtained and presented. The graphene film used as patterned electrode in the project is grown by chemical vapor deposition (CVD) over copper foils, which demonstrate the properties of low sheet resistance and high transmittance of more than 90% in current stage. The key fabrication of the arrayed LC microlens based on graphene electrode includes the graphene transfering, ultraviolet lithography, ICP etching, liquid crystalline polymer encapsulation, etc. In the test of the arrayed LC microlens, the point spread functions (PSF) of incident laser beams with different wavelengths, such as red laser of ~600nm wavelength, and green laser of ~532nm wavelength, have been obtained. In addition, the arrayed LC microlenses are also used in visible light imaging. During the imaging tests, each microlens in the arrayed LC microlens can perform imaging process, independently.

  2. Fabrication and electrical properties of single wall carbon nanotube channel and graphene electrode based transistors arrays

    SciTech Connect

    Seo, M.; Kim, H.; Kim, Y. H.; Yun, H.; McAllister, K.; Lee, S. W.; Na, J.; Kim, G. T.; Lee, B. J.; Kim, J. J.; Jeong, G. H.; Lee, I.; Kim, K. S.

    2015-07-20

    A transistor structure composed of an individual single-walled carbon nanotube (SWNT) channel with a graphene electrode was demonstrated. The integrated arrays of transistor devices were prepared by transferring patterned graphene electrode patterns on top of the aligned SWNT along one direction. Both single and multi layer graphene were used for the electrode materials; typical p-type transistor and Schottky diode behavior were observed, respectively. Based on our fabrication method and device performances, several issues are suggested and discussed to improve the device reliability and finally to realize all carbon based future electronic systems.

  3. Fabrication of comb interdigitated electrodes array (IDA) for a microbead-based electrochemical assay system.

    PubMed

    Kim, Sang Kyung; Hesketh, Peter J; Li, Changming; Thomas, Jennifer H; Halsall, H Brian; Heineman, William R

    2004-11-01

    This research is directed towards developing a more sensitive and rapid electrochemical sensor for enzyme labeled immunoassays by coupling redox cycling at interdigitated electrode arrays (IDA) with the enzyme label beta-galactosidase. Coplanar and comb IDA electrodes with a 2.4 microm gap were fabricated and their redox cycling currents were measured. ANSYS was used to model steady state currents for electrodes with different geometries. Comb IDA electrodes enhanced the signal about three times more than the coplanar IDAs, which agreed with the results of the simulation. Magnetic microbead-based enzyme assay, as a typical example of biochemical detection, was done using the comb and coplanar IDAs. The enzymes could be placed close to the sensing electrodes (approximately 10 microm for the comb IDAs) and detection took less than 1 min with a limit of detection of 70 amol of beta-galactosidase. We conclude that faster and more sensitive assays can be achieved with the comb IDA. PMID:15522606

  4. Controllable in-situ cell electroporation with cell positioning and impedance monitoring using micro electrode array

    PubMed Central

    Guo, Xiaoliang; Zhu, Rong

    2016-01-01

    This paper reports a novel microarray chip for in-situ, real-time and selective electroporation on individual cells integrated with cell positioning and impedance monitoring. An array of quadrupole-electrode units (termed positioning electrodes) and pairs of planar center electrodes located at the centers of each quadrupole-electrode unit were fabricated on the chip. The positioning electrodes are used to trap and position living cells onto the center electrodes based on negative dielectrophoresis (nDEP). The center electrodes are used for in-situ cell electroporation, and also used to measure cell impedance for monitoring cellular dynamics in real time. Controllably selective electroporation and electrical measurement on the cells in array are realized. We present an evidence of selective electroporation through use of fluorescent dyes. Subsequently we use in-situ and real-time impedance measurement to monitor the process, which demonstrates the dynamic behavior of the cell electroporation. Finally, we show the use of this device to perform successful transfection onto individual HeLa cells with vector DNA encoding a green fluorescent. PMID:27507603

  5. Controllable in-situ cell electroporation with cell positioning and impedance monitoring using micro electrode array.

    PubMed

    Guo, Xiaoliang; Zhu, Rong

    2016-01-01

    This paper reports a novel microarray chip for in-situ, real-time and selective electroporation on individual cells integrated with cell positioning and impedance monitoring. An array of quadrupole-electrode units (termed positioning electrodes) and pairs of planar center electrodes located at the centers of each quadrupole-electrode unit were fabricated on the chip. The positioning electrodes are used to trap and position living cells onto the center electrodes based on negative dielectrophoresis (nDEP). The center electrodes are used for in-situ cell electroporation, and also used to measure cell impedance for monitoring cellular dynamics in real time. Controllably selective electroporation and electrical measurement on the cells in array are realized. We present an evidence of selective electroporation through use of fluorescent dyes. Subsequently we use in-situ and real-time impedance measurement to monitor the process, which demonstrates the dynamic behavior of the cell electroporation. Finally, we show the use of this device to perform successful transfection onto individual HeLa cells with vector DNA encoding a green fluorescent. PMID:27507603

  6. Electrical stimulation with a penetrating optic nerve electrode array elicits visuotopic cortical responses in cats

    NASA Astrophysics Data System (ADS)

    Lu, Yiliang; Yan, Yan; Chai, Xinyu; Ren, Qiushi; Chen, Yao; Li, Liming

    2013-06-01

    Objective. A visual prosthesis based on penetrating electrode stimulation within the optic nerve (ON) is a potential way to restore partial functional vision for blind patients. We investigated the retinotopic organization of ON stimulation and its spatial resolution. Approach. A five-electrode array was inserted perpendicularly into the ON or a single electrode was advanced to different depths within the ON (˜1-2 mm behind the eyeball, 13 cats). A sparse noise method was used to map ON electrode position and the visual cortex. Cortical responses were recorded by a 5 × 6 array. The visuotopic correspondence between the retinotopic position of the ON electrode was compared with the visual evoked cortical map and the electrical evoked potentials elicited in response to ON stimulation. Main results. Electrical stimulation with penetrating ON electrodes elicited cortical responses in visuotopographically corresponding areas of the cortex. Stimulation of the temporal side of the ON elicited cortical responses corresponding to the central visual field. The visual field position shifted from the lower to central visual field as the electrode penetrated through the depth of the ON. A spatial resolution of ˜ 2° to 3° within a limited cortical visuotopic representation could be obtained by this approach. Significance. Visuotopic electrical stimulation with a relatively fine spatial resolution can be accomplished using penetrating electrodes implanted at multiple sites and at different depths within the ON just behind the globe. This study also provides useful experimental data for the design of electrode density and the distribution of penetrating ON electrodes for a visual prosthesis.

  7. Flexible active electrode arrays with ASICs that fit inside the rat's spinal canal.

    PubMed

    Giagka, Vasiliki; Demosthenous, Andreas; Donaldson, Nick

    2015-12-01

    Epidural spinal cord electrical stimulation (ESCS) has been used as a means to facilitate locomotor recovery in spinal cord injured humans. Electrode arrays, instead of conventional pairs of electrodes, are necessary to investigate the effect of ESCS at different sites. These usually require a large number of implanted wires, which could lead to infections. This paper presents the design, fabrication and evaluation of a novel flexible active array for ESCS in rats. Three small (1.7 mm(2)) and thin (100 μm) application specific integrated circuits (ASICs) are embedded in the polydimethylsiloxane-based implant. This arrangement limits the number of communication tracks to three, while ensuring maximum testing versatility by providing independent access to all 12 electrodes in any configuration. Laser-patterned platinum-iridium foil forms the implant's conductive tracks and electrodes. Double rivet bonds were employed for the dice microassembly. The active electrode array can deliver current pulses (up to 1 mA, 100 pulses per second) and supports interleaved stimulation with independent control of the stimulus parameters for each pulse. The stimulation timing and pulse duration are very versatile. The array was electrically characterized through impedance spectroscopy and voltage transient recordings. A prototype was tested for long term mechanical reliability when subjected to continuous bending. The results revealed no track or bond failure. To the best of the authors' knowledge, this is the first time that flexible active electrode arrays with embedded electronics suitable for implantation inside the rat's spinal canal have been proposed, developed and tested in vitro. PMID:26466839

  8. Multi-electrode array technologies for neuroscience and cardiology

    NASA Astrophysics Data System (ADS)

    Spira, Micha E.; Hai, Aviad

    2013-02-01

    At present, the prime methodology for studying neuronal circuit-connectivity, physiology and pathology under in vitro or in vivo conditions is by using substrate-integrated microelectrode arrays. Although this methodology permits simultaneous, cell-non-invasive, long-term recordings of extracellular field potentials generated by action potentials, it is 'blind' to subthreshold synaptic potentials generated by single cells. On the other hand, intracellular recordings of the full electrophysiological repertoire (subthreshold synaptic potentials, membrane oscillations and action potentials) are, at present, obtained only by sharp or patch microelectrodes. These, however, are limited to single cells at a time and for short durations. Recently a number of laboratories began to merge the advantages of extracellular microelectrode arrays and intracellular microelectrodes. This Review describes the novel approaches, identifying their strengths and limitations from the point of view of the end users -- with the intention to help steer the bioengineering efforts towards the needs of brain-circuit research.

  9. [Nonsurgical retreatment in a case of a radiolucent apical lesion].

    PubMed

    Vicente Gómez, A; Rodríguez Ponce, A

    1989-01-01

    We present a case of failure that was helpful solved without surgical endodontic treatment. We don't achieve clinical success besides endodontic treatment was twice remade. Finally we decided to put a temporary filling with calcium hydroxide and wait until apical radiolucency disappear and complete our treatment with gutta-percha, sealer and lateral condensation. PMID:2640036

  10. Electrothermal flow on electrodes arrays at physiological conductivities.

    PubMed

    Koklu, Anil; Tansel, Osman; Oksuzoglu, Hakan; Sabuncu, Ahmet C

    2016-04-01

    AC electrothermal (ET) flow is inevitable for microfluidic systems dissipating electric energy in a conducting medium. Therefore, many practical applications of biomicrofluidics are prone to ET flow. Here, a series of observations are reported on ET flow in a microfluidic chamber that houses three electrode pairs. The observations indicate that the variations in liquid conductivity and channel height critically impact the structure and magnitude of the flow field. Observations indicate that after a critical conductivity a global ET flow is present in the chamber, while at lower conductivities a vortex is present at every electrode edge. In addition, no ET flow is observed when the chamber height is kept below a critical value at physiological conductivity (∼1.5 S/m). The experimental observations are compared with the numerical simulations of ET flow. The validity of the assumptions made in the current AC ET flow theory is also discussed in the light of the experimental data. The observations can be critical while designing microfluidic systems that involve power dissipation in conductive fluids. PMID:27074854

  11. Photoelectrocatalytic activity of a hydrothermally grown branched Zno nanorod-array electrode for paracetamol degradation.

    PubMed

    Lin, Chin Jung; Liao, Shu-Jun; Kao, Li-Cheng; Liou, Sofia Ya Hsuan

    2015-06-30

    Hierarchical branched ZnO nanorod (B-ZnR) arrays as an electrode for efficient photoelectrocatalytic degradation of paracetamol were grown on fluorine-doped tin oxide substrates using a solution route. The morphologic and structural studies show the ZnO trunks are single-crystalline hexagonal wurtzite ZnO with a [0001] growth direction and are densely covered by c-axis-oriented ZnO branches. The obvious enhancement in photocurrent response of the B-ZnR electrode was obtained than that in the ZnO nanoparticle (ZnO NP) electrode. For the photoelectrocatalytic degradation of paracetamol in 20 h, the conversion fraction of the drug increased from 32% over ZnO NP electrode to 62% over B-ZnR arrays with about 3-fold increase in initial reaction rate. The light intensity-dependent photoelectrocatalytic experiment indicated that the superior performance over the B-ZnR electrode was mainly ascribed to the increased specific surface area without significantly sacrificing the charge transport and pollutant diffusion efficiencies. Two aromatic intermediate compounds were observed and eventually converted into harmless carboxylic acids and ammonia. Hierarchical tree-like ZnO arrays can be considered effective alternatives to improve photoelectro degradation rates without the need for expensive additives. PMID:25748997

  12. Study on Fabrication and UV Photoelectric Property of TiO2 Nanotube Array Electrodes.

    PubMed

    Fu, Yao; Duan, Xiao-Long; Xing, Ming-Ming; Luo, Xi-Xian; Zhang, Ying-Hui; Liu, Wang

    2016-04-01

    Highly ordered TiO2 nanotube array electrodes were successfully fabricated by a two-step anodization method on Ti sheet substrates in an electrolyte composed of ammonium fluoride, deionized water, and glycol. The tube wall was smooth, and the average internal and external diameters, wall thickness, and tube length achieved were 80 nm, 90 nm, 10 nm, and 9 µm, respectively. X-ray diffraction and field emission scanning electron microscopy results revealed that the TiO2 nanotube arrays presented an amorphous structure. When calcined at 300 °C, the arrays crystallized into the anatase phase, and the crystallization degree of the oxide layer increased as the temperature rose. Calcinating at 400 °C did not obviously disrupt the porous structure of the highly ordered arrays. However, higher temperature enlarged the diameter of the nanotube array and roughened the tube wall. When the temperature reached 600 °C, the nanotube mouth broke because of the excessive stress, causing the oxide layer's thinness and nanotube mouth clogging. The photoelectric test showed that the electrode presented obvious photoresponse under 300-400 nm UV excitation (maximized at 360 nm). The degree of crystallization and the micro-structure of the oxide layer can significantly affect the photoelectric properties of the electrode. After calcination at 400 °C, the TiO2 nanotube arrays, with highly ordered tubular structure directly connected to the Ti substrate, can ensure the rapid transportation of photo-induced electrons to the Ti substrate, while the high crystallinity of the arrays can help reduce the defect density of the nanotube and extend the lifetime of the photo-induced carriers. The electrode showed the best photoelectric property, and the photocurrent intensity was maximized (29.6 µA). However, the calcination process with over-temperature resulted in substantial loss of the TiO2 oxide layer, mouth clogging, and a severe decline in the photoelectric properties. PMID:27451743

  13. Nanoscale electrode arrays produced with microscale lithographic techniques for use in biomedical sensing applications.

    PubMed

    Terry, Jonathan G; Schmüser, Ilka; Underwood, Ian; Corrigan, Damion K; Freeman, Neville J; Bunting, Andrew S; Mount, Andrew R; Walton, Anthony J

    2013-12-01

    A novel technique for the production of nanoscale electrode arrays that uses standard microfabrication processes and micron-scale photolithography is reported here in detail. These microsquare nanoband edge electrode (MNEE) arrays have been fabricated with highly reproducible control of the key array dimensions, including the size and pitch of the individual elements and, most importantly, the width of the nanoband electrodes. The definition of lateral features to nanoscale dimensions typically requires expensive patterning techniques that are complex and low-throughput. However, the fabrication methodology used here relies on the fact that vertical dimensions (i.e. layer thicknesses) have long been manufacturable at the nanoscale using thin film deposition techniques that are well established in mainstream microelectronics. The authors report for the first time two aspects that highlight the particular suitability of these MNEE array systems for probe monolayer biosensing. The first is simulation, which shows the enhanced sensitivity to the redox reaction of the solution redox couple. The second is the enhancement of probe film functionalisation observed for the probe film model molecule, 6-mercapto-1-hexanol compared with microsquare electrodes. Such surface modification for specific probe layer biosensing and detection is of significance for a wide range of biomedical and other sensing and analytical applications. PMID:24206769

  14. Individual Optimization of the Insertion of a Preformed Cochlear Implant Electrode Array

    PubMed Central

    Rau, Thomas S.; Lenarz, Thomas; Majdani, Omid

    2015-01-01

    Purpose. The aim of this study was to show that individual adjustment of the curling behaviour of a preformed cochlear implant (CI) electrode array to the patient-specific shape of the cochlea can improve the insertion process in terms of reduced risk of insertion trauma. Methods. Geometry and curling behaviour of preformed, commercially available electrode arrays were modelled. Additionally, the anatomy of each small, medium-sized, and large human cochlea was modelled to consider anatomical variations. Finally, using a custom-made simulation tool, three different insertion strategies (conventional Advanced Off-Stylet (AOS) insertion technique, an automated implementation of the AOS technique, and a manually optimized insertion process) were simulated and compared with respect to the risk of insertion-related trauma. The risk of trauma was evaluated using a newly developed “trauma risk” rating scale. Results. Using this simulation-based approach, it was shown that an individually optimized insertion procedure is advantageous compared with the AOS insertion technique. Conclusion. This finding leads to the conclusion that, in general, consideration of the specific curling behaviour of a CI electrode array is beneficial in terms of less traumatic insertion. Therefore, these results highlight an entirely novel aspect of clinical application of preformed perimodiolar electrode arrays in general. PMID:26448764

  15. Photoelectrocatalytic degradation of tetracycline by highly effective TiO2 nanopore arrays electrode.

    PubMed

    Liu, Yanbiao; Gan, Xiaojie; Zhou, Baoxue; Xiong, Bitao; Li, Jinhua; Dong, Chaoping; Bai, Jing; Cai, Weimin

    2009-11-15

    The widely utilization of pharmaceutical and personal care products (PPCPs) in the pharmaceutical therapies and agricultural husbandry has led to the worldwide pollution in the environment. In this study, the photoelectrocatalytic (PEC) behaviors of typical PPCPs, tetracycline (TC), were performed via a highly effective TiO(2) nanopore arrays (TNPs) electrode, comparing with electrochemical (EC) and photocatalytic (PC) process. A significant photoelectrochemical synergetic effect in TC degradation was observed on the TNPs electrode and the rate constant for the PEC process of TNPs electrode was approximately 6.7 times as high as its PC process. The TC removal rate achieved approximately 80% within 3h PEC reaction by TNPs electrode, which is approximately 25% higher than that obtained for a conventional coated TiO(2) nanofilm electrode fabricated by sol-gel method. The possible mechanism involved in the PEC degradation of TC by TNPs electrode was discussed. Furthermore, the TNPs electrode also shows enhanced photocurrent response compared with that for the coated TiO(2) nanofilm electrode. Such kind of TiO(2) nanopores will have many potential applications in various areas as an outstanding photoelectrochemical material. PMID:19577843

  16. Triggering cell detachment from patterned electrode arrays by programmed subcellular release.

    PubMed

    Wildt, Bridget; Wirtz, Denis; Searson, Peter C

    2010-07-01

    Programmed subcellular release is an in vitro technique for the quantitative study of cell detachment. The dynamics of cell contraction are measured by releasing cells from surfaces to which they are attached with spatial and temporal control. Release of subcellular regions of cells is achieved by plating cells on an electrode array created by standard microfabrication methods. The electrodes are then biochemically functionalized with an arginine-glycine-aspartic acid (RGD)-terminated thiol. Application of a voltage pulse results in electrochemical desorption of the RGD-terminated thiols, triggering cell detachment. This method allows for the study of the full cascade of events from detachment to subsequent subcellular reorganization. Fabrication of the electrode arrays may take 1-2 d. Preparation for experiments, including surface functionalization and cell plating, can be completed in 10 h. A series of cell release experiments on one device may last several hours. PMID:20595956

  17. Model-based analysis of multiple electrode array stimulation for epiretinal visual prostheses

    NASA Astrophysics Data System (ADS)

    Mueller, Jerel K.; Grill, Warren M.

    2013-06-01

    Objective. Epiretinal stimulation, which uses an array of electrodes implanted on the inner retinal surface to relay a representation of the visual scene to the neuronal elements of the retina, has seen considerable success. The objective of the present study was to quantify the effects of multi-electrode stimulation on the patterns of neural excitation in a computational model of epiretinal stimulation. Approach. A computational model of retinal ganglion cells was modified to represent the morphology of human retinal ganglion cells and validated against published experimental data. The ganglion cell model was then combined with a model of an axon of the nerve fiber layer to produce a population model of the inner retina. The response of the population of model neurons to epiretinal stimulation with a multi-electrode array was quantified across a range of electrode geometries using a novel means to quantify the model response—the minimum radius circle bounding the activated model neurons as a proxy for the evoked phosphene. Main results. Multi-electrode stimulation created unique phosphenes, such that the number of potential phosphenes can far exceed the number of electrode contacts. Significance. The ability to exploit the spatial and temporal interactions of stimulation may be critical to improvements in the performance of epiretinal prostheses.

  18. Fabrication of nano-gap electrode arrays by the construction and selective chemical etching of nano-crosswire stacks

    NASA Technical Reports Server (NTRS)

    Son, Kyung-Ah (Inventor); Prokopuk, Nicholas (Inventor)

    2008-01-01

    Methods of fabricating nano-gap electrode structures in array configurations, and the structures so produced. The fabrication method involves depositing first and second pluralities of electrodes comprising nanowires using processes such as lithography, deposition of metals, lift-off processes, and chemical etching that can be performed using conventional processing tools applicable to electronic materials processing. The gap spacing in the nano-gap electrode array is defined by the thickness of a sacrificial spacer layer that is deposited between the first and second pluralities of electrodes. The sacrificial spacer layer is removed by etching, thereby leaving a structure in which the distance between pairs of electrodes is substantially equal to the thickness of the sacrificial spacer layer. Electrode arrays with gaps measured in units of nanometers are produced. In one embodiment, the first and second pluralities of electrodes are aligned in mutually orthogonal orientations.

  19. Nitrogen-Doped Carbon Nanocoil Array Integrated on Carbon Nanofiber Paper for Supercapacitor Electrodes.

    PubMed

    Choi, Won Ho; Choi, Mi Jin; Bang, Jin Ho

    2015-09-01

    Integrating a nanostructured carbon array on a conductive substrate remains a challenging task that presently relies primarily on high-vacuum deposition technology. To overcome the problems associated with current vacuum techniques, we demonstrate the formation of an N-doped carbon array by pyrolysis of a polymer array that was electrochemically grown on carbon fiber paper. The resulting carbon array was investigated for use as a supercapacitor electrode. In-depth surface characterization results revealed that the microtextural properties, surface functionalities, and degree of nitrogen incorporated into the N-doped carbon array can be delicately controlled by manipulating carbonization temperatures. Furthermore, electrochemical measurements showed that subtle changes in these physical properties resulted in significant changes in the capacitive behavior of the N-doped carbon array. Pore structures and nitrogen/oxygen functional groups, which are favorable for charge storage, were formed at low carbonization temperatures. This result showed the importance of having a comprehensive understanding of how the surface characteristics of carbon affect its capacitive performance. When utilized as a substrate in a pseudocapacitive electrode material, the N-doped carbon array maximizes capacitive performance by simultaneously achieving high gravimetric and areal capacitances due to its large surface area and high electrical conductivity. PMID:26264641

  20. High Density Nano-Electrode Array for Radiation Detection

    SciTech Connect

    Mano Misra

    2010-05-07

    Bulk single crystals of Cd1-xZnxTe (x=0.04 to x=0.2) compound semiconductor is used for room temperature radiation detection. The production of large volume of Cd1-xZnxTe with low defect density is expensive. As a result there is a growing research interest in the production of nanostructured compound semiconductors such as Cd1-xZnxTe in an electrochemical route. In this investigation, Cd1-xZnxTe ternary compound semiconductor, referred as CZT, was electrodeposited in the form of nanowires onto a TiO2 nanotubular template from propylene carbonate as the non-aqueous electrolyte, using a pulse-reverse electrodeposition process at 130 ºC. The template acted as a support in growing ordered nanowire of CZT which acts as a one dimensional conductor. Cyclic Voltammogram (CV) studies were conducted in determining the potentials for the growth of nanowires of uniform stoichiometry. The morphologies and composition of CZT were characterized by using SEM, TEM and XRD. The STEM mapping carried out on the nanowires showed the uniform distribution of Cd, Zn and Te elements. TEM image showed that the nanowires were polycrystalline in nature. The Mott-Schottky analysis carried on the nanowires showed that the nanowires were a p-type semiconductor. The carrier density, band gap and resistivity of the Cd0.9Zn0.1Te nanowires were 4.29x1013 cm-3, 1.56 eV and 2.76x1011Ω-cm respectively. The high resistivity was attributed to the presence of deep defect states such as cadmium vacancies or Te antisites which were created by the anodic cycle of the pulse-reverse electrodeposition process. Stacks of series connected CZT nanowire arrays were tested with different bias potentials. The background current was in the order of tens of picoamperes. When exposed to radiation source Amerecium-241 (60 KeV, 4 μCi), the stacked CZT nanowires arrays showed sensing behavior. The sensitivity of the nanowire arrays increased as the number of stacks increased. The preliminary results indicate that the

  1. Biochips Containing Arrays of Carbon-Nanotube Electrodes

    NASA Technical Reports Server (NTRS)

    Li, Jun; Meyyappan, M.; Koehne, Jessica; Cassell, Alan; Chen, Hua

    2008-01-01

    Biochips containing arrays of nanoelectrodes based on multiwalled carbon nanotubes (MWCNTs) are being developed as means of ultrasensitive electrochemical detection of specific deoxyribonucleic acid (DNA) and messenger ribonucleic acid (mRNA) biomarkers for purposes of medical diagnosis and bioenvironmental monitoring. In mass production, these biochips could be relatively inexpensive (hence, disposable). These biochips would be integrated with computer-controlled microfluidic and microelectronic devices in automated hand-held and bench-top instruments that could be used to perform rapid in vitro genetic analyses with simplified preparation of samples. Carbon nanotubes are attractive for use as nanoelectrodes for detection of biomolecules because of their nanoscale dimensions and their chemical properties.

  2. Intracellular Protein Delivery and Gene Transfection by Electroporation Using a Microneedle Electrode Array

    PubMed Central

    Choi, Seong-O; Kim, Yeu-Chun; Lee, Jeong Woo; Park, Jung-Hwan

    2012-01-01

    The impact of many biopharmaceuticals, including protein- and gene-based therapies, has been limited by the need for better methods of delivery into cells within tissues. Here, we present intracellular delivery of molecules and transfection with plasmid DNA by electroporation using a novel microneedle electrode array designed for targeted treatment of skin and other tissue surfaces. The microneedle array is molded out of polylactic acid. Electrodes and circuitry required for electroporation are applied to the microneedle array surface by a new metal-transfer micromolding method. The microneedle array maintains mechanical integrity after insertion into pig cadaver skin and is able to electroporate human prostate cancer cells in vitro. Quantitative measurements show that increasing electroporation pulse voltage increases uptake efficiency of calcein and bovine serum albumin, whereas increasing pulse length has lesser effects over the range studied. Uptake of molecules by up to 50 % of cells and transfection of 12 % of cells with a gene for green fluorescent protein is demonstrated at high cell viability. We conclude that the microneedle electrode array is able to electroporate cells, resulting in intracellular uptake of molecules, and has potential applications to improve intracellular delivery of proteins, DNA and other biopharmaceuticals. PMID:22328093

  3. Step-by-step instructions for retina recordings with perforated multi electrode arrays.

    PubMed

    Reinhard, Katja; Tikidji-Hamburyan, Alexandra; Seitter, Hartwig; Idrees, Saad; Mutter, Marion; Benkner, Boris; Münch, Thomas A

    2014-01-01

    Multi-electrode arrays are a state-of-the-art tool in electrophysiology, also in retina research. The output cells of the retina, the retinal ganglion cells, form a monolayer in many species and are well accessible due to their proximity to the inner retinal surface. This structure has allowed the use of multi-electrode arrays for high-throughput, parallel recordings of retinal responses to presented visual stimuli, and has led to significant new insights into retinal organization and function. However, using conventional arrays where electrodes are embedded into a glass or ceramic plate can be associated with three main problems: (1) low signal-to-noise ratio due to poor contact between electrodes and tissue, especially in the case of strongly curved retinas from small animals, e.g. rodents; (2) insufficient oxygen and nutrient supply to cells located on the bottom of the recording chamber; and (3) displacement of the tissue during recordings. Perforated multi-electrode arrays (pMEAs) have been found to alleviate all three issues in brain slice recordings. Over the last years, we have been using such perforated arrays to study light evoked activity in the retinas of various species including mouse, pig, and human. In this article, we provide detailed step-by-step instructions for the use of perforated MEAs to record visual responses from the retina, including spike recordings from retinal ganglion cells and in vitro electroretinograms (ERG). In addition, we provide in-depth technical and methodological troubleshooting information, and show example recordings of good quality as well as examples for the various problems which might be encountered. While our description is based on the specific equipment we use in our own lab, it may also prove useful when establishing retinal MEA recordings with other equipment. PMID:25165854

  4. Hierarchical mesoporous nickel cobaltite nanoneedle/carbon cloth arrays as superior flexible electrodes for supercapacitors

    PubMed Central

    2014-01-01

    Hierarchical mesoporous NiCo2O4 nanoneedle arrays on carbon cloth have been fabricated by a simple hydrothermal approach combined with a post-annealing treatment. Such unique array nanoarchitectures exhibit remarkable electrochemical performance with high capacitance and desirable cycle life at high rates. When evaluated as an electrode material for supercapacitors, the NiCo2O4 nanoneedle arrays supported on carbon cloth was able to deliver high specific capacitance of 660 F g-1 at current densities of 2 A g-1 in 2 M KOH aqueous solution. In addition, the composite electrode shows excellent mechanical behavior and long-term cyclic stability (91.8% capacitance retention after 3,000 cycles). The fabrication method presented here is facile, cost-effective, and scalable, which may open a new pathway for real device applications. PMID:24661431

  5. Preparation of nickel nanowire arrays electrode for urea electro-oxidation in alkaline medium

    NASA Astrophysics Data System (ADS)

    Guo, Fen; Ye, Ke; Cheng, Kui; Wang, Guiling; Cao, Dianxue

    2015-03-01

    Fully metallic nickel nanowire arrays (NWAs) electrode is prepared by electrodepositing nickel within the pores and over-plating on the surface of polycarbonate template (PCT) with subsequent dissolution of the template in dichloromethane. The as-prepared electrode is characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM) and transmission electron microscopy (TEM). Urea electro-oxidation reaction in KOH solution on the nickel NWAs electrode is investigated by cyclic voltammetry (CV), chronoamperometry (CA) and electrochemical impedance spectroscopy (EIS) tests. The results show that the nickel NWAs electrode achieves an onset oxidation potential of 0.25 V (vs. Ag/AgCl) and a peak current density of 160 mA cm-2 in 5 mol L-1 KOH and 0.33 mol L-1 urea accompanied with considerable stability.

  6. The fabrication of low-impedance nanoporous gold multiple-electrode arrays for neural electrophysiology studies

    PubMed Central

    Seker, Erkin; Berdichevsky, Yevgeny; Begley, Matthew R; Reed, Michael L; Staley, Kevin J; Yarmush, Martin L

    2011-01-01

    Neural electrodes are essential tools for the study of the nervous system and related diseases. Low electrode impedance is a figure of merit for sensitive detection of neural electrical activity and numerous studies have aimed to reduce impedance. Unfortunately, most of these efforts have been tethered by a combination of poor functional coating adhesion, complicated fabrication techniques, and poor fabrication repeatability. We address these issues with a facile method for reliably producing multiple-electrode arrays with low impedance by patterning highly adherent nanoporous gold films using conventional microfabrication techniques. The high surface area-to-volume ratio of self-assembled nanoporous gold results in a more than 25-fold improvement in the electrode-electrolyte impedance, where at 1 kHz, 850 kΩ impedance for conventional Au electrodes is reduced to 30 kΩ for nanoporous gold electrodes. Low impedance provides a superior signal-to-noise ratio for detection of neural activity in noisy environments. We systematically studied the effect of film morphology on electrode impedance and successfully recorded field potentials from rat hippocampal slices. Here, we present our fabrication approach, the relationship between film morphology and impedance, and field potential recordings. PMID:20203356

  7. Design of Circle Array Pattern for Transparent Nanomesh-Type Electrodes.

    PubMed

    Shin, Seungsu; Ganorkar, Shraddha; Kim, Jungyoon; Kim, Young-Hwan; Kim, Yong Tae; Kim, Seong-Il

    2015-10-01

    In this study, we report simulation results for the optical properties of nanomesh-type electrodes for transparent electrode. Usually, indium tin oxide (ITO) is commonly used for transparent conductor to solar cell, display, LED and other electronic modules. However, the cost is high due to the rarity of indium. An alternative way is use of transparent nanomesh-type metal electrode for solar cell. Finite different time domain (FDTD) method was used to simulate and analyze their optical properties. Various array patterns (square, circle and circle hexagonal array) of metal on glass (SiO2) substrates were designed and their properties of transmission and reflection were simulated by using the broad band (λ = 300~1200 nm) plane wave source. To compare basic characteristics of each pattern, various structural parameters such as hole diameter, pitch and metal thickness were applied. The effect of three typical metals, such as Ag, Au, and Al was also compared. In the results, we will discuss about large dip of transmission appeared at the particular wavelength region from the circle array pattern, which is design with pitch of 500 nm at the wavelength range 700 to 800 nm. The surface plasmonpolaritons (SPP) effect can be the cause of large dip and we could find a broad and high transmission from the properly designed in nanomesh-type electrodes, which was calculated as a function of wavelength. PMID:26726388

  8. High frequency glow discharges at atmospheric pressure with micro-structured electrode arrays

    NASA Astrophysics Data System (ADS)

    Baars-Hibbe, L.; Sichler, P.; Schrader, C.; Lucas, N.; Gericke, K.-H.; Büttgenbach, S.

    2005-02-01

    Micro-structured electrode (MSE) arrays allow the generation of large-area uniform glow discharges over a wide pressure range up to atmospheric pressure. The electrode widths, thicknesses and distances in the micrometre range are realized by means of modern micro-machining and galvanic techniques. The electrode distance, the gap width d, is small enough to generate sufficiently high electric field strengths to ignite gas discharges by applying only moderate radio frequency (RF, 13.56 MHz) voltages (80-390 V in Ne, He, Ar, N2 and air). The non-thermal plasma system is characterized by a special probe measuring the electric parameters. We tested MSE arrays with d = 70, 25 and 15 µm. The MSE driven plasmas show a different behaviour from conventional RF discharge plasmas. Due to the very small electrode gap width we can describe the behaviour of the charged particles in the RF field of our system with the dc Townsend breakdown theory, depending on the pressure range and gas. With decreasing pressure, the gas discharges, especially in Ne and He, are increasingly dominated by field electron emission. With the MSE arrays as plasma sources several applications were developed and successfully tested, e.g. decomposition of waste gases and sterilization of food packaging materials at atmospheric pressure.

  9. Graphene-based carbon-layered electrode array technology for neural imaging and optogenetic applications

    PubMed Central

    Park, Dong-Wook; Schendel, Amelia A.; Mikael, Solomon; Brodnick, Sarah K.; Richner, Thomas J.; Ness, Jared P.; Hayat, Mohammed R.; Atry, Farid; Frye, Seth T.; Pashaie, Ramin; Thongpang, Sanitta; Ma, Zhenqiang; Williams, Justin C.

    2014-01-01

    Neural micro-electrode arrays that are transparent over a broad wavelength spectrum from ultraviolet to infrared could allow for simultaneous electrophysiology and optical imaging, as well as optogenetic modulation of the underlying brain tissue. The long-term biocompatibility and reliability of neural micro-electrodes also require their mechanical flexibility and compliance with soft tissues. Here we present a graphene-based, carbon-layered electrode array (CLEAR) device, which can be implanted on the brain surface in rodents for high-resolution neurophysiological recording. We characterize optical transparency of the device at >90% transmission over the ultraviolet to infrared spectrum and demonstrate its utility through optical interface experiments that use this broad spectrum transparency. These include optogenetic activation of focal cortical areas directly beneath electrodes, in vivo imaging of the cortical vasculature via fluorescence microscopy and 3D optical coherence tomography. This study demonstrates an array of interfacing abilities of the CLEAR device and its utility for neural applications. PMID:25327513

  10. A carbon-fiber electrode array for long-term neural recording

    PubMed Central

    Guitchounts, Grigori; Markowitz, Jeffrey E.; Liberti, William A.; Gardner, Timothy J.

    2013-01-01

    Problem addressed Chronic neural recording in behaving animals is an essential method for studies of neural circuit function. However, stable recordings from small, densely packed neurons remains challenging, particularly over time-scales relevant for learning. Methodology We describe an assembly method for a 16 channel electrode array consisting of carbon fibers (<5 μm diameter) individually insulated with Parylene-C and fire-sharpened. The diameter of the array is approximately 26 microns, along the full extent of the implant. Results Carbon fiber arrays were tested in HVC (used as a proper name), a song motor nucleus, of singing zebra finches where individual neurons discharge with temporally precise patterns. Previous reports of activity in this population of neurons has required the use of high impedance electrodes on movable microdrives. Here, the carbon fiber electrodes provided stable multi-unit recordings over time-scales of months. Spike-sorting indicated that the multi-unit signals were dominated by one, or a small number of cells. Stable firing patterns during singing confirmed the stability of these clusters over time-scales of months. In addition, from a total of 10 surgeries, 16 projection neurons were found. This cell type is characterized by sparse - stereotyped firing firing patterns, providing unambiguous confirmation of single cell recordings. Significance Carbon fiber electrode bundles may provide a scalable solution for long-term neural recordings of densely packed neurons. PMID:23860226

  11. Interdigitated electrode array based sensors for environmental monitoring of caesium

    NASA Astrophysics Data System (ADS)

    Nickson, I. D.; Boxall, C.; Port, S. N.

    2010-03-01

    The requirement for on-line and in-situ monitoring of analytes in process and effluent streams and in ground waters has become increasingly more important in recent years. We therefore describe the development of the transduction element for a fully automated online instrument for the detection of caesium. The sensor layer for this instrument employs an Ion Selective Conductimetric Microsensor (ISCOM) as the detector. This is based upon a plasticized polymeric membrane incorporating a selective ionophore, overlaying two interdigitated microelectrode arrays. A direct relationship has been observed between the bulk conductance (as determined by the microelectrodes) of the ionophore loaded membrane and the concentration of the primary ions in solution. Caesium selective ISCOMs were prepared using an ion selective membrane containing the commercially available ionophore Calix [6]arene-hexaacetic acid hexaethyl ester, polyvinylchloride (PVC) and plasticiser Nitrophenylether (NPOE). The relative levels of membrane components have also been varied in order to further enhance the ISCOM response. We also present preliminary data concerning the caesium selectivity with respect to a range of possible interferents, including rubidium.

  12. Adult Cortical Plasticity Studied with Chronically Implanted Electrode Arrays

    PubMed Central

    Abe, Hiroshi; McManus, Justin N.J.; Ramalingam, Nirmala; Li, Wu; Marik, Sally A.; Meyer zum Alten Borgloh, Stephan

    2015-01-01

    The functional architecture of adult cerebral cortex retains a capacity for experience-dependent change. This is seen after focal binocular lesions as rapid changes in receptive field (RF) of the lesion projection zone (LPZ) in the primary visual cortex (V1). To study the dynamics of the circuitry underlying these changes longitudinally, we implanted microelectrode arrays in macaque (Macaca mulatta) V1, eliminating the possibility of sampling bias, which was a concern in previous studies. With this method, we observed a rapid initial recovery in the LPZ and, during the following weeks, 63–89% of the sites in the LPZ showed recovery of visual responses with significant position tuning. The RFs shifted ∼3° away from the scotoma. In the absence of a lesion, visual stimulation surrounding an artificial scotoma did not elicit visual responses, suggesting that the postlesion RF shifts resulted from cortical reorganization. Interestingly, although both spikes and LFPs gave consistent prelesion position tuning, only spikes reflected the postlesion remapping. PMID:25673865

  13. Analysis of traveling-wave electro-osmotic pumping with double-sided electrode arrays

    NASA Astrophysics Data System (ADS)

    Yeh, Hung-Chun; Yang, Ruey-Jen; Luo, Win-Jet

    2011-05-01

    In this paper, a series of numerical simulations was performed to investigate the pumping performance of electro-osmotic micropumps containing electrode arrays patterned on the upper and lower sides of a microchannel. The simulations have been analyzed with a linear electro-osmotic model based upon the Debye-Hückel theory of the double layer. The potential drop across the diffuse layer is assumed to be less than 25 mV (kBT/e), and there is a linear response between the surface charge and the voltage drop across the double layer. The double layer is not resolved but is lumped into effective parameters that are imported from the Debye-Hückel and Stern layers. We examined the effects of the relative positioning of the electrodes in the opposing arrays (i.e., symmetrical or staggered), and the phase lag and the angular frequency of the alternating current (ac) signals applied to the electrodes within the two arrays. A critical height of the microchannel was observed, below which the interactions of the applied electrical potentials on the walls became significant. The optimum pumping effect was obtained when the electrode arrays were symmetrical to one another around the centerline of the channel and were activated by ac potentials with a 0° phase shift. The corresponding angular frequency of the maximum pumping velocity for different phase shifts of the applied ac signals was also determined. Overall, the simulation results presented in this paper provide a useful insight into the optimal design parameters and operating conditions for micropumps containing two arrays of microelectrodes on the microchannel walls.

  14. Fabrication of a carbon nanotube protruding electrode array for a retinal prosthesis

    NASA Astrophysics Data System (ADS)

    Wang, Ke; Dai, Hongjie; Fishman, Harvey A.; Harris, James S.

    2005-01-01

    Implantable retinal prosthetic devices consisting of microelectrode arrays are being built in attempts to restore vision. Current retinal prostheses use metal planar electrodes. We are developing a novel electro-neural interface using carbon nanotube (CNT) bundles as flexible, protruding microelectrodes. We have synthesized vertically self-assembled, multi-walled CNT bundles by thermal chemical vapor deposition. Using conventional silicon-based micro-fabrication processes, these CNT bundles were integrated onto pre-patterned circuits. CNT protruding electrodes have significant potentials in providing safer stimulation for retinal prostheses. They could also act as recording units to sense electrical and chemical activities in neural systems for fundamental neuroscience research.

  15. Optimization of discharge types and electrode structure in a cylinder discharge reactor with saw-wheel array electrodes

    NASA Astrophysics Data System (ADS)

    Zhang, Chunyang; Shang, Kefeng; Lu, Na; Li, Jie; Wu, Yan

    2013-03-01

    The application of corona discharge technology in gas purification and wastewater treatment has been received great attention in recent years. The configuration of discharge electrode and the discharge types directly affect the discharge power and the power density, and then affect the generation of active species as well as the removal efficiency of pollutants. A novel cylinder-type discharge reactor with saw-wheel-array electrodes was developed for removal of SO2/NOx from flue gas, and influence factors such as electrode structure (ratio of spacing of saw-wheel slices and discharge distance, herein defined as R) and power supply types (positive DC, negative DC, and pulse power) on discharge characteristics and the output power was discussed. The experimental results show that the current and output power of three types of discharges firstly increased with R increasing from 0.3-1.7, and then tended to a stability from 1.7-2.5 while the power density reached a maximum at the ratio of 1.7.

  16. Nano electrode arrays for in-situ identification and quantification of chemicals in water.

    SciTech Connect

    Gurule, Natalia J.; Kelly, Michael James; Brevnov, Dmitri A.; Ashby, Carol Iris Hill; Pfeifer, Kent Bryant; Yelton, William Graham

    2004-12-01

    The nano electrode arrays for in-situ identification and quantification of chemicals in water progress in four major directions. (1) We developed and engineering three nanoelectrode array designs which operate in a portable field mode or as distributed sensor network for water systems. (2) To replace the fragile glass electrochemical cells using in the lab, we design and engineered field-ready sampling heads that combine the nanoelectrode arrays with a high-speed potentiostat. (3) To utilize these arrays in a portable system we design and engineered a light weight high-speed potentiostat with pulse widths from 2 psec. to 100 msec. or greater. (4) Finally, we developed the parameters for an analytical method in low-conductivity solutions for Pb(II) detection, with initial studies for the analysis of As(III) and As(V) analysis in natural water sources.

  17. Microneedle Electrode Array for Electrical Impedance Myography to Characterize Neurogenic Myopathy.

    PubMed

    Li, Zhao; Li, Yi; Liu, Mingsheng; Cui, Liying; Yu, Yude

    2016-05-01

    Electrical impedance myography (EIM) is a noninvasive technique for neuromuscular assessment, wherein a low-intensity alternating current is applied to a muscle, and the consequent surface voltage patterns are evaluated. Commercial wet electrodes are most commonly used for EIM. However, these electrodes are not suitable for use on small muscles, as they do not effectively solve the problem of high electrode-skin contact impedance (ESCI) that negatively influences the quality of recorded biopotentials. To address this problem, we fabricated a novel microneedle electrode array (MEA) that consists of 124-µm-long microneedles. Compared to wet electrodes, the MEA could pierce through the outer skin surface in a painless and micro-invasive manner, and could thus effectively reduce ESCI. The MEA has excellent test-retest reproducibility, with intraclass correlation coefficients exceeding 0.920. When used in combination with EIM, the MEA differentiated the affected muscles from the unaffected muscles in patients with neurogenic myopathy, by using EIM parameters of reactance and phase (p = 0.023 and 0.008, respectively). Thus, the novel MEA is a practical and reusable device for EIM assessment in cases of neurogenic myopathy. However, further refinement of the electrode is needed to enhance the clinical application of the system. PMID:26407702

  18. A comparison of headnet electrode arrays for electrical impedance tomography of the human head.

    PubMed

    Tidswell, A T; Bagshaw, A P; Holder, D S; Yerworth, R J; Eadie, L; Murray, S; Morgan, L; Bayford, R H

    2003-05-01

    Three types of commercially available headnet electrode arrays, designed for use in EEG, and conventional EEG Ag/AgCl cup electrodes were tested on human subjects, and a realistic, saline-filled head-shaped tank was prepared with vegetable skin to simulate human skin in order to determine the optimum electrode system for electrical impedance tomography (EIT) of the human head. Impedance changes during EIT acquisition were produced in healthy volunteers during a finger-thumb apposition task and in tanks by the insertion of a Perspex rod. Signal-to-baseline noise, measured from raw EIT data, was 2.3 +/- 0.3 and 2.3 +/- 0.2 for the human and tank data, respectively. In both the human and tank experiments, a commercial hydrogel elasticated electrode headnet produced the least amount of baseline noise, and was the only headnet in the human data with noise levels acceptable for EIT imaging. Image quality measured in the tank was similar for most of the headnets tested, except that the EEG electrodes produced a higher positional error and electrodes in a geodesic elasticated net produced images with worse subjective image quality. Overall, the hydrogel elasticated headnet was judged to be the most suitable for human neuroimaging with EIT. PMID:12812436

  19. A Cosmic Dust Sensor Based on an Array of Grid Electrodes

    NASA Astrophysics Data System (ADS)

    Li, Y. W.; Bugiel, S.; Strack, H.; Srama, R.

    2014-04-01

    We described a low mass and high sensitivity cosmic dust trajectory sensor using a array of grid segments[1]. the sensor determines the particle velocity vector and the particle mass. An impact target is used for the detection of the impact plasma of high speed particles like interplanetary dust grains or high speed ejecta. Slower particles are measured by three planes of grid electrodes using charge induction. In contrast to conventional Dust Trajectory Sensor based on wire electrodes, grid electrodes a robust and sensitive design with a trajectory resolution of a few degree. Coulomb simulation and laboratory tests were performed in order to verify the instrument design. The signal shapes are used to derive the particle plane intersection points and to derive the exact particle trajectory. The accuracy of the instrument for the incident angle depends on the particle charge, the position of the intersection point and the signal-to-noise of the charge sensitive amplifier (CSA). There are some advantages of this grid-electrodes based design with respect to conventional trajectory sensor using individual wire electrodes: the grid segment electrodes show higher amplitudes (close to 100%induced charge) and the overall number of measurement channels can be reduced. This allows a compact instrument with low power and mass requirements.

  20. Time of Flight Electrochemistry: Diffusion Coefficient Measurements Using Interdigitated Array (IDA) Electrodes

    SciTech Connect

    Liu, Fei; Kolesov, Grigory; Parkinson, Bruce A.

    2014-09-26

    A simple and straightforward method for measuring diffusion coefficients using interdigitated array (IDA) electrodes is reported. The method does not require that the exact electrode area be known but depends only the size of the gap between the IDA electrode pairs. Electroactive molecules produced at the generator electrode of the IDA by a voltage step or scan can diffuse to the collector electrode and the time delay before the current for the reverse electrochemical reaction is detected at the collector is used to calculate the diffusion coefficient. The measurement of the diffusion rate of Ru(NH3)6+2 in aqueous solution has been used as an example measuring diffusion coefficients using this method. Additionally, a digital simulation of the electrochemical response of the IDA electrodes was used to simulate the entire current/voltage/time behavior of the system and verify the experimentally measured diffusion coefficients. This work was supported as part of the Center for Molecular Electrocatalysis, an Energy Frontier Research Center funded by the Department of Energy, Office of Science, Office of Basic Energy Sciences.

  1. Neural recording stability of chronic electrode arrays in freely behaving primates.

    PubMed

    Linderman, Michael D; Gilja, Vikash; Santhanam, Gopal; Afshar, Afsheen; Ryu, Stephen; Meng, Teresa H; Shenoy, Krishna V

    2006-01-01

    Chronically implanted electrode arrays have enabled a broad range of advances, particularly in the field of neural prosthetics. Those successes motivate development of prototype implantable prosthetic processors for long duration, continuous use in freely behaving subjects. However, traditional experimental protocols have provided limited information regarding the stability of the electrode arrays and their neural recordings. In this paper we present preliminary results derived from long duration neural recordings in a freely behaving primate which show variations in action potential shape and RMS noise across a range of time scales. These preliminary results suggest that spike sorting algorithms can no longer assume stable neural signals and will need to transition to adaptive signal processing methodologies to maximize performance. PMID:17946626

  2. Optimization of focality and direction in dense electrode array transcranial direct current stimulation (tDCS)

    NASA Astrophysics Data System (ADS)

    Guler, Seyhmus; Dannhauer, Moritz; Erem, Burak; Macleod, Rob; Tucker, Don; Turovets, Sergei; Luu, Phan; Erdogmus, Deniz; Brooks, Dana H.

    2016-06-01

    Objective. Transcranial direct current stimulation (tDCS) aims to alter brain function non-invasively via electrodes placed on the scalp. Conventional tDCS uses two relatively large patch electrodes to deliver electrical current to the brain region of interest (ROI). Recent studies have shown that using dense arrays containing up to 512 smaller electrodes may increase the precision of targeting ROIs. However, this creates a need for methods to determine effective and safe stimulus patterns as the number of degrees of freedom is much higher with such arrays. Several approaches to this problem have appeared in the literature. In this paper, we describe a new method for calculating optimal electrode stimulus patterns for targeted and directional modulation in dense array tDCS which differs in some important aspects with methods reported to date. Approach. We optimize stimulus pattern of dense arrays with fixed electrode placement to maximize the current density in a particular direction in the ROI. We impose a flexible set of safety constraints on the current power in the brain, individual electrode currents, and total injected current, to protect subject safety. The proposed optimization problem is convex and thus efficiently solved using existing optimization software to find unique and globally optimal electrode stimulus patterns. Main results. Solutions for four anatomical ROIs based on a realistic head model are shown as exemplary results. To illustrate the differences between our approach and previously introduced methods, we compare our method with two of the other leading methods in the literature. We also report on extensive simulations that show the effect of the values chosen for each proposed safety constraint bound on the optimized stimulus patterns. Significance. The proposed optimization approach employs volume based ROIs, easily adapts to different sets of safety constraints, and takes negligible time to compute. An in-depth comparison study gives

  3. Theoretical Optimization of Stimulation Strategies for a Directionally Segmented Deep Brain Stimulation Electrode Array.

    PubMed

    Xiao, YiZi; Peña, Edgar; Johnson, Matthew D

    2016-02-01

    Programming deep brain stimulation (DBS) systems currently involves a clinician manually sweeping through a range of stimulus parameter settings to identify the setting that delivers the most robust therapy for a patient. With the advent of DBS arrays with a higher number and density of electrodes, this trial and error process becomes unmanageable in a clinical setting. This study developed a computationally efficient, model-based algorithm to estimate an electrode configuration that will most strongly activate tissue within a volume of interest. The cerebellar-receiving area of motor thalamus, the target for treating essential tremor with DBS, was rendered from imaging data and discretized into grid points aligned in approximate afferent and efferent axonal pathway orientations. A finite-element model (FEM) was constructed to simulate the volumetric tissue voltage during DBS. We leveraged the principle of voltage superposition to formulate a convex optimization-based approach to maximize activating function (AF) values at each grid point (via three different criteria), hence increasing the overall probability of action potential initiation and neuronal entrainment within the target volume. For both efferent and afferent pathways, this approach achieved global optima within several seconds. The optimal electrode configuration and resulting AF values differed across each optimization criteria and between axonal orientations. This approach only required a set of FEM simulations equal to the number of DBS array electrodes, and could readily accommodate anisotropic-inhomogeneous tissue conductances or other axonal orientations. The algorithm provides an efficient, flexible determination of optimal electrode configurations for programming DBS arrays. PMID:26208259

  4. Efficient piezoelectric ZnO nanogenerators based on Au-coated silica sphere array electrode

    PubMed Central

    2013-01-01

    We reported ZnO nanorod-based piezoelectric nanogenerators (NGs) with Au-coated silica sphere array as an efficient top electrode. This electrode can readily bend the ZnO nanorods due to its enhanced surface roughness, thus resulting in more increased and regular piezoelectric charge output. Under a low external pushing force of 0.3 kgf, the output current and voltage were increased by approximately 2.01 and 1.51 times, respectively, in comparison with a conventional Au top electrode without silica spheres. Also, the effect of Au-coated silica spheres on the bending radius of ZnO nanorods was theoretically investigated. PMID:24305510

  5. Fabrication of a Micro-Needle Array Electrode by Thermal Drawing for Bio-Signals Monitoring.

    PubMed

    Ren, Lei; Jiang, Qing; Chen, Keyun; Chen, Zhipeng; Pan, Chengfeng; Jiang, Lelun

    2016-01-01

    A novel micro-needle array electrode (MAE) fabricated by thermal drawing and coated with Ti/Au film was proposed for bio-signals monitoring. A simple and effective setup was employed to form glassy-state poly (lactic-co-glycolic acid) (PLGA) into a micro-needle array (MA) by the thermal drawing method. The MA was composed of 6 × 6 micro-needles with an average height of about 500 μm. Electrode-skin interface impedance (EII) was recorded as the insertion force was applied on the MAE. The insertion process of the MAE was also simulated by the finite element method. Results showed that MAE could insert into skin with a relatively low compression force and maintain stable contact impedance between the MAE and skin. Bio-signals, including electromyography (EMG), electrocardiography (ECG), and electroencephalograph (EEG) were also collected. Test results showed that the MAE could record EMG, ECG, and EEG signals with good fidelity in shape and amplitude in comparison with the commercial Ag/AgCl electrodes, which proves that MAE is an alternative electrode for bio-signals monitoring. PMID:27322278

  6. Fabrication of a Micro-Needle Array Electrode by Thermal Drawing for Bio-Signals Monitoring

    PubMed Central

    Ren, Lei; Jiang, Qing; Chen, Keyun; Chen, Zhipeng; Pan, Chengfeng; Jiang, Lelun

    2016-01-01

    A novel micro-needle array electrode (MAE) fabricated by thermal drawing and coated with Ti/Au film was proposed for bio-signals monitoring. A simple and effective setup was employed to form glassy-state poly (lactic-co-glycolic acid) (PLGA) into a micro-needle array (MA) by the thermal drawing method. The MA was composed of 6 × 6 micro-needles with an average height of about 500 μm. Electrode-skin interface impedance (EII) was recorded as the insertion force was applied on the MAE. The insertion process of the MAE was also simulated by the finite element method. Results showed that MAE could insert into skin with a relatively low compression force and maintain stable contact impedance between the MAE and skin. Bio-signals, including electromyography (EMG), electrocardiography (ECG), and electroencephalograph (EEG) were also collected. Test results showed that the MAE could record EMG, ECG, and EEG signals with good fidelity in shape and amplitude in comparison with the commercial Ag/AgCl electrodes, which proves that MAE is an alternative electrode for bio-signals monitoring. PMID:27322278

  7. In vivo neuronal action potential recordings via three-dimensional microscale needle-electrode arrays

    PubMed Central

    Fujishiro, Akifumi; Kaneko, Hidekazu; Kawashima, Takahiro; Ishida, Makoto; Kawano, Takeshi

    2014-01-01

    Very fine needle-electrode arrays potentially offer both low invasiveness and high spatial resolution of electrophysiological neuronal recordings in vivo. Herein we report the penetrating and recording capabilities of silicon-growth-based three-dimensional microscale-diameter needle-electrodes arrays. The fabricated needles exhibit a circular-cone shape with a 3-μm-diameter tip and a 210-μm length. Due to the microscale diameter, our silicon needles are more flexible than other microfabricated silicon needles with larger diameters. Coating the microscale-needle-tip with platinum black results in an impedance of ~600 kΩ in saline with output/input signal amplitude ratios of more than 90% at 40 Hz–10 kHz. The needles can penetrate into the whisker barrel area of a rat's cerebral cortex, and the action potentials recorded from some neurons exhibit peak-to-peak amplitudes of ~300 μVpp. These results demonstrate the feasibility of in vivo neuronal action potential recordings with a microscale needle-electrode array fabricated using silicon growth technology. PMID:24785307

  8. In vivo neuronal action potential recordings via three-dimensional microscale needle-electrode arrays

    NASA Astrophysics Data System (ADS)

    Fujishiro, Akifumi; Kaneko, Hidekazu; Kawashima, Takahiro; Ishida, Makoto; Kawano, Takeshi

    2014-05-01

    Very fine needle-electrode arrays potentially offer both low invasiveness and high spatial resolution of electrophysiological neuronal recordings in vivo. Herein we report the penetrating and recording capabilities of silicon-growth-based three-dimensional microscale-diameter needle-electrodes arrays. The fabricated needles exhibit a circular-cone shape with a 3-μm-diameter tip and a 210-μm length. Due to the microscale diameter, our silicon needles are more flexible than other microfabricated silicon needles with larger diameters. Coating the microscale-needle-tip with platinum black results in an impedance of ~600 kΩ in saline with output/input signal amplitude ratios of more than 90% at 40 Hz-10 kHz. The needles can penetrate into the whisker barrel area of a rat's cerebral cortex, and the action potentials recorded from some neurons exhibit peak-to-peak amplitudes of ~300 μVpp. These results demonstrate the feasibility of in vivo neuronal action potential recordings with a microscale needle-electrode array fabricated using silicon growth technology.

  9. In vivo neuronal action potential recordings via three-dimensional microscale needle-electrode arrays.

    PubMed

    Fujishiro, Akifumi; Kaneko, Hidekazu; Kawashima, Takahiro; Ishida, Makoto; Kawano, Takeshi

    2014-01-01

    Very fine needle-electrode arrays potentially offer both low invasiveness and high spatial resolution of electrophysiological neuronal recordings in vivo. Herein we report the penetrating and recording capabilities of silicon-growth-based three-dimensional microscale-diameter needle-electrodes arrays. The fabricated needles exhibit a circular-cone shape with a 3-μm-diameter tip and a 210-μm length. Due to the microscale diameter, our silicon needles are more flexible than other microfabricated silicon needles with larger diameters. Coating the microscale-needle-tip with platinum black results in an impedance of ~600 kΩ in saline with output/input signal amplitude ratios of more than 90% at 40 Hz-10 kHz. The needles can penetrate into the whisker barrel area of a rat's cerebral cortex, and the action potentials recorded from some neurons exhibit peak-to-peak amplitudes of ~300 μVpp. These results demonstrate the feasibility of in vivo neuronal action potential recordings with a microscale needle-electrode array fabricated using silicon growth technology. PMID:24785307

  10. Three-dimensional nanotube electrode arrays for hierarchical tubular structured high-performance pseudocapacitors.

    PubMed

    Gao, Yuan; Lin, Yuanjing; Chen, Jiaqi; Lin, Qingfeng; Wu, Yue; Su, Wenjun; Wang, Wenli; Fan, Zhiyong

    2016-07-21

    Ordered three-dimensional (3-D) tubular arrays are highly attractive candidates for high performance pseudocapacitor electrodes. Here, we report 3-D fluorine doped tin oxide (FTO) tubular arrays fabricated by a cost-effective ultrasonic spray pyrolysis (USP) method in anodic aluminum oxide (AAO) channels with high uniformity. The large surface area of such a structure leads to remarkable surface area enhancement up to 51.8 times compared to a planar structure. Combining with electrochemically deposited manganese dioxide (MnO2) nanoflakes on the inner side wall of the FTO nanotubes, the unique hierarchical tubular structured pseudocapacitor electrode demonstrated the highest areal capacitance of 193.8 mF cm(-2) at the scan rate of 5 mV s(-1) and 184 mF cm(-2) at the discharge current density of 0.6 mA cm(-2), which is 18.5 times that of a planar electrode. And it also showed a volumetric capacitance of 112.6 F cm(-3) at the scan rate of 5 mV s(-1) and 108.8 F cm(-3) at the discharge current density of 0.6 mA cm(-2). In addition, the cyclic stability test also indicated that a nanostructured pseudocapacitive electrode has a much larger capacitance retention after 3000 cycles of the charge-discharge process compared with a planar electrode, primarily due to the mechanical stability of the nanostructure. Moreover, pseudocapacitor device fabrication based on such electrodes shows the volumetric capacitance of 17.5 F cm(-3), and the highest specific energy of 1.56 × 10(-3) Wh cm(-3). With the merit of facile fabrication procedures and largely enhanced electrochemical performance, such a 3-D structure has high potency for energy storage systems for a wide range of practical applications. PMID:27337295

  11. Single-crystalline Ni(OH)2 and NiO nanoplatelet arrays as supercapacitor electrodes

    NASA Astrophysics Data System (ADS)

    Li, Jiangtian; Zhao, Wei; Huang, Fuqiang; Manivannan, Ayyakkannu; Wu, Nianqiang

    2011-12-01

    Vertically aligned Ni(OH)2 and NiO single-crystalline nanoplatelet arrays were directly grown on the fluorine-doped tin oxide (FTO) substrate by a simple hydrothermal method. The effects of the hydrothermal parameters on the morphology and crystal structure of the nanoarray film were investigated. Controlling the ammonia and persulfate concentrations was the key to controlling the morphology of the nanoarray film. The experimental results showed that the single-crystalline NiO nanoplatelet array was a promising candidate for the supercapacitor electrode. It exhibited a high specific capacitance, prompt charge/discharge rate, and good stability of cycling performance. It is believed that the vertically oriented aligned single-crystalline NiO nanoplatelet array is beneficial to the charge transfer in the electrode and to the ion transport in the solution during redox reaction.Vertically aligned Ni(OH)2 and NiO single-crystalline nanoplatelet arrays were directly grown on the fluorine-doped tin oxide (FTO) substrate by a simple hydrothermal method. The effects of the hydrothermal parameters on the morphology and crystal structure of the nanoarray film were investigated. Controlling the ammonia and persulfate concentrations was the key to controlling the morphology of the nanoarray film. The experimental results showed that the single-crystalline NiO nanoplatelet array was a promising candidate for the supercapacitor electrode. It exhibited a high specific capacitance, prompt charge/discharge rate, and good stability of cycling performance. It is believed that the vertically oriented aligned single-crystalline NiO nanoplatelet array is beneficial to the charge transfer in the electrode and to the ion transport in the solution during redox reaction. Electronic supplementary information (ESI) available: XRD patterns of Ni(OH)2 and NiO powders; SEM and TEM images of Ni(OH)2 and NiO nanoplatelet arrays; and electrochemical performances for NiO nanoarrays and powders. See

  12. Stripe- or square-patterned arrays of tin dioxide nanowires for use in lithium-ion battery electrodes

    NASA Astrophysics Data System (ADS)

    Lee, Sang Ho; Kim, Won Bae

    2016-03-01

    This paper reports a novel electrode design for use in electrochemical lithium-ion storage. 3-dimensional patterns of tin dioxide nanowires that are grown directly over current collectors are suggested as electrode frameworks, representing the synergetic combination of nanometer-sized 1-dimensional electrode materials and micrometer-scaled hollow channels formed between the patterned nanowire arrays. The lithium-ion storage properties are investigated by changing the pattern geometries of these nanowire arrays in the shape of stripes and squares. The proposed electrode platforms show the enhanced electrochemical storage performances, which might be attributed to the effective diffusion of liquid phase electrolyte through the hollow channels between these patterned nanowire arrays. More interestingly, with increasing the hollow channels in these proposed systems, the high-rate performance and cycling stability are improved even further due to the structural effect of these electrode frameworks.

  13. Hierarchical Mesoporous Zinc-Nickel-Cobalt Ternary Oxide Nanowire Arrays on Nickel Foam as High-Performance Electrodes for Supercapacitors.

    PubMed

    Wu, Chun; Cai, Junjie; Zhang, Qiaobao; Zhou, Xiang; Zhu, Ying; Shen, Pei Kang; Zhang, Kaili

    2015-12-01

    Nickel foam supported hierarchical mesoporous Zn-Ni-Co ternary oxide (ZNCO) nanowire arrays are synthesized by a simple two-step approach including a hydrothermal method and subsequent calcination process and directly utilized for supercapacitive investigation for the first time. The nickel foam supported hierarchical mesoporous ZNCO nanowire arrays possess an ultrahigh specific capacitance value of 2481.8 F g(-1) at 1 A g(-1) and excellent rate capability of about 91.9% capacitance retention at 5 A g(-1). More importantly, an asymmetric supercapacitor with a high energy density (35.6 Wh kg(-1)) and remarkable cycle stability performance (94% capacitance retention over 3000 cycles) is assembled successfully by employing the ZNCO electrode as positive electrode and activated carbon as negative electrode. The remarkable electrochemical behaviors demonstrate that the nickel foam supported hierarchical mesoporous ZNCO nanowire array electrodes are highly desirable for application as advanced supercapacitor electrodes. PMID:26575957

  14. Individually addressable electrode array for multianalyte electrochemiluminescent immunoassay based on a sequential triggering strategy.

    PubMed

    Wang, Lin; Wei, Wei; Han, Jing; Fu, Zhifeng

    2012-02-01

    Multianalyte immunoassay in a single run is often necessary to monitor or quantitate several components in a complex sample matrix for various purposes. In this paper we present a novel, individually addressable electrode array for sequential electrochemiluminescent (ECL) immunoassay using a non-array detector. An immunosensor array was fabricated by site-selectively immobilizing multiple antigens on different electrodes. With a competitive immunoassay format, the amounts of the bound Ru(bpy)(3)(2+) derivative labeled antibodies decreased with the increase of the antigens in the sample, and the ECL signals from different immunosensors were collected in turn by a photomultiplier with the aid of a home-made single-pore-three-throw switch. Using human IgG and rat IgG as model analytes, this multianalyte immunoassay showed detection limits down to 8.9 and 7.2 ng mL(-1) for them, respectively. The results for real sample analysis demonstrated that this strategy can provide a simple, sensitive, low-cost and high-throughput ECL immunosensor array for clinical diagnosis. PMID:22159267

  15. Concurrent recordings of bladder afferents from multiple nerves using a microfabricated PDMS microchannel electrode array.

    PubMed

    Delivopoulos, Evangelos; Chew, Daniel J; Minev, Ivan R; Fawcett, James W; Lacour, Stéphanie P

    2012-07-21

    In this paper we present a compliant neural interface designed to record bladder afferent activity. We developed the implant's microfabrication process using multiple layers of silicone rubber and thin metal so that a gold microelectrode array is embedded within four parallel polydimethylsiloxane (PDMS) microchannels (5 mm long, 100 μm wide, 100 μm deep). Electrode impedance at 1 kHz was optimized using a reactive ion etching (RIE) step, which increased the porosity of the electrode surface. The electrodes did not deteriorate after a 3 month immersion in phosphate buffered saline (PBS) at 37 °C. Due to the unique microscopic topography of the metal film on PDMS, the electrodes are extremely compliant and can withstand handling during implantation (twisting and bending) without electrical failure. The device was transplanted acutely to anaesthetized rats, and strands of the dorsal branch of roots L6 and S1 were surgically teased and inserted in three microchannels under saline immersion to allow for simultaneous in vivo recordings in an acute setting. We utilized a tripole electrode configuration to maintain background noise low and improve the signal to noise ratio. The device could distinguish two types of afferent nerve activity related to increasing bladder filling and contraction. To our knowledge, this is the first report of multichannel recordings of bladder afferent activity. PMID:22569953

  16. A liquid crystal microlens array with aluminum and graphene electrodes for plenoptic imaging

    NASA Astrophysics Data System (ADS)

    Lei, Yu; Tong, Qing; Luo, Jun; Zhang, Xinyu; Sang, Hongshi; Xie, Changsheng

    2015-12-01

    Currently, several semiconducting oxide materials such as typical indium tin oxide are widely used as the transparent conducting electrodes (TCEs) in liquid crystal microlens arrays. In this paper, we fabricate a liquid crystal microlens array using graphene rather than semiconducting oxides as the TCE. Common optical experiments are carried out to acquire the focusing features of the graphene-based liquid crystal microlens array (GLCMLA) driven electrically. The acquired optical fields show that the GLCMLA can converge incident collimating lights efficiently. The relationship between the focal length and the applied voltage signal is presented. Then the GLCMLA is deployed in a plenoptic camera prototype and the raw images are acquired so as to verify their imaging capability. Our experiments demonstrate that graphene has already presented a broad application prospect in the area of adaptive optics.

  17. A parylene-silicon cochlear electrode array with integrated position sensors.

    PubMed

    Wang, Jianbai; Gulari, Mayurachat N; Wise, Kensall D

    2006-01-01

    A thin-film cochlear electrode array has been developed for a cochlear prosthesis to achieve improved sound perception and position accuracy. The array is fabricated using a bulk-silicon micromachining process that allows parylene deposition and patterning at wafer level, followed by a wet silicon release etch that is compatible with the use of boron etch-stops. The process is capable of realizing arrays with substrates stressed to hug the modiolar wall in the rest state and whose stiffness can be adjusted over a wide range. Built-in tip and curvature sensors respond to tip contact and bending-induced shank stress, respectively during in-vitro and in-vivo implants. The process is also compatible with the integration of parylene ribbon cables for lead transfer to an implanted electronics package. PMID:17946554

  18. A high performance three-phase enzyme electrode based on superhydrophobic mesoporous silicon nanowire arrays for glucose detection

    NASA Astrophysics Data System (ADS)

    Xu, Chenlong; Song, Zhiqian; Xiang, Qun; Jin, Jian; Feng, Xinjian

    2016-03-01

    We describe here a high performance oxygen-rich three-phase enzyme electrode based on superhydrophobic mesoporous silicon nanowire arrays for glucose detection. We demonstrate that its linear detection upper limit is 30 mM, more than 15 times higher than that can be obtained on the normal enzyme-electrode. Notably, the three-phase enzyme electrode output is insensitive to the significant oxygen level fluctuation in analyte solution.We describe here a high performance oxygen-rich three-phase enzyme electrode based on superhydrophobic mesoporous silicon nanowire arrays for glucose detection. We demonstrate that its linear detection upper limit is 30 mM, more than 15 times higher than that can be obtained on the normal enzyme-electrode. Notably, the three-phase enzyme electrode output is insensitive to the significant oxygen level fluctuation in analyte solution. Electronic supplementary information (ESI) available. See DOI: 10.1039/c5nr08370b

  19. Evaluation of Platinum-Black Stimulus Electrode Array for Electrical Stimulation of Retinal Cells in Retinal Prosthesis System

    NASA Astrophysics Data System (ADS)

    Watanabe, Taiichiro; Kobayashi, Risato; Komiya, Ken; Fukushima, Takafumi; Tomita, Hiroshi; Sugano, Eriko; Kurino, Hiroyuki; Tanaka, Tetsu; Tamai, Makoto; Koyanagi, Mitsumasa

    2007-04-01

    A retinal prosthesis system with a three-dimensionally (3D) stacked LSI chip has been proposed. We fabricated a new implantable stimulus electrode array deposited with Platinum-black (Pt-b) on a polyimide-based flexible printed circuit (FPC) for the electrical stimulation of the retinal cells. Impedance measurement of the Pt-b electrode-electrolyte interface in a saline solution was performed and the Pt-b electrode realized a very low impedance. The power consumption at the electrode array when retinal cells were stimulated by a stimulus current was evaluated. The power consumption of the Pt-b stimulus electrode array was 91% lower than that of a previously fabricated Al stimulus electrode array due to a convexo-concave surface. In the cytotoxicity test (CT), we confirmed that Pt implantation induced no cellular degeneration of the rat retina. In the animal experiments, electrically evoked potential (EEP) was successfully recorded using Japanese white rabbits. These results indicate that electrical stimulation using the Pt-b stimulus electrode array can restore visual sensation.

  20. A high performance three-phase enzyme electrode based on superhydrophobic mesoporous silicon nanowire arrays for glucose detection.

    PubMed

    Xu, Chenlong; Song, Zhiqian; Xiang, Qun; Jin, Jian; Feng, Xinjian

    2016-04-14

    We describe here a high performance oxygen-rich three-phase enzyme electrode based on superhydrophobic mesoporous silicon nanowire arrays for glucose detection. We demonstrate that its linear detection upper limit is 30 mM, more than 15 times higher than that can be obtained on the normal enzyme-electrode. Notably, the three-phase enzyme electrode output is insensitive to the significant oxygen level fluctuation in analyte solution. PMID:26983941

  1. Non-invasive method for selection of electrodes and stimulus parameters for FES applications with intrafascicular arrays

    NASA Astrophysics Data System (ADS)

    Dowden, B. R.; Frankel, M. A.; Normann, R. A.; Clark, G. A.

    2012-02-01

    High-channel-count intrafascicular electrode arrays provide comprehensive and selective access to the peripheral nervous system. One practical difficulty in using several electrode arrays to evoke coordinated movements in paralyzed limbs is the identification of the appropriate stimulation channels and stimulus parameters to evoke desired movements. Here we present the use of a six degree-of-freedom load cell placed under the foot of a feline to characterize the muscle activation produced by three 100-electrode Utah Slanted Electrode Arrays (USEAs) implanted into the femoral nerves, sciatic nerves, and muscular branches of the sciatic nerves of three cats. Intramuscular stimulation was used to identify the endpoint force directions produced by 15 muscles of the hind limb, and these directions were used to classify the forces produced by each intrafascicular USEA electrode as flexion or extension. For 451 USEA electrodes, stimulus intensities for threshold and saturation muscle forces were identified, and the 3D direction and linearity of the force recruitment curves were determined. Further, motor unit excitation independence for 198 electrode pairs was measured using the refractory technique. This study demonstrates the utility of 3D endpoint force monitoring as a simple and non-invasive metric for characterizing the muscle-activation properties of hundreds of implanted peripheral nerve electrodes, allowing for electrode and parameter selection for neuroprosthetic applications.

  2. Response profiles of murine spiral ganglion neurons on multi-electrode arrays

    NASA Astrophysics Data System (ADS)

    Hahnewald, Stefan; Tscherter, Anne; Marconi, Emanuele; Streit, Jürg; Widmer, Hans Rudolf; Garnham, Carolyn; Benav, Heval; Mueller, Marcus; Löwenheim, Hubert; Roccio, Marta; Senn, Pascal

    2016-02-01

    Objective. Cochlear implants (CIs) have become the gold standard treatment for deafness. These neuroprosthetic devices feature a linear electrode array, surgically inserted into the cochlea, and function by directly stimulating the auditory neurons located within the spiral ganglion, bypassing lost or not-functioning hair cells. Despite their success, some limitations still remain, including poor frequency resolution and high-energy consumption. In both cases, the anatomical gap between the electrode array and the spiral ganglion neurons (SGNs) is believed to be an important limiting factor. The final goal of the study is to characterize response profiles of SGNs growing in intimate contact with an electrode array, in view of designing novel CI devices and stimulation protocols, featuring a gapless interface with auditory neurons. Approach. We have characterized SGN responses to extracellular stimulation using multi-electrode arrays (MEAs). This setup allows, in our view, to optimize in vitro many of the limiting interface aspects between CIs and SGNs. Main results. Early postnatal mouse SGN explants were analyzed after 6-18 days in culture. Different stimulation protocols were compared with the aim to lower the stimulation threshold and the energy needed to elicit a response. In the best case, a four-fold reduction of the energy was obtained by lengthening the biphasic stimulus from 40 μs to 160 μs. Similarly, quasi monophasic pulses were more effective than biphasic pulses and the insertion of an interphase gap moderately improved efficiency. Finally, the stimulation with an external electrode mounted on a micromanipulator showed that the energy needed to elicit a response could be reduced by a factor of five with decreasing its distance from 40 μm to 0 μm from the auditory neurons. Significance. This study is the first to show electrical activity of SGNs on MEAs. Our findings may help to improve stimulation by and to reduce energy consumption of CIs and

  3. Amperometric biosensor based on 3D ordered freestanding porous Pt nanowire array electrode.

    PubMed

    Wang, Yunli; Zhu, Yingchun; Chen, Jingjing; Zeng, Yi

    2012-09-28

    A three-dimensionally (3D) ordered freestanding porous platinum (Pt) nanowire array electrode (PPNWAE) with pores of several nanometers in size and a Pt nanowire array electrode (PNWAE) without pores were facilely fabricated by metal electrodeposition and direct integration with a Pt disk electrode. The unusual PPNWAE with high active area showed excellent sensitivity (0.36 mA cm(-2) mM(-1)) and a wide detection range (4.5 μM-27.1 mM) to hydrogen peroxide (H(2)O(2)). A glucose oxidase (GOD)-based biosensor (PPNWAE/GOD) with a considerably wide detection range (4.5 μM-189.5 mM) to glucose was demonstrated. Furthermore, a lower detection limit, higher sensitivity and smaller value of Michaelis-Menten constant k(m) were recorded for PPNWAE-based biosensors compared with PNWAE-based biosensors. Particularly, the response current to glucose of PPNWAE/GOD was ca. 100% higher than that of PNWAE/GOD and the response current to H(2)O(2) of PPNWAE was ca. 50% higher than that of PNWAE, owing to the granular and rougher porous nanowire surface enabling greater bioactivity for GOD. The selectivity of PPNWAE/GOD glucose biosensor was also estimated. PMID:22898987

  4. Template preparation of Pt-Ru and Pt nanowire array electrodes on a Ti/Si substrate for methanol electro-oxidation

    NASA Astrophysics Data System (ADS)

    Zhao, Guang-Yu; Xu, Cai-Ling; Guo, Dao-Jun; Li, Hua; Li, Hu-Lin

    Pt and Pt-Ru nanowire array electrodes were obtained by dc (direct current) electrodeposition of Pt and Ru into the pores of an anodic aluminum oxide (AAO) template on a Ti/Si substrate. Transmission electron microscope (TEM) examination showed all the nanowires had a uniform diameter of about 30 nm. The brush shaped Pt and Pt-Ru nanowire array electrodes could be seen clearly by scanning electron microscope. Pt and Pt-Ru nanowire array electrodes gave the X-ray diffraction pattern of a face-centered cubic (fcc) crystal structure. The electro-oxidation of methanol on these electrodes was investigated at room temperature using cyclic voltammetry. The results demonstrated that the alloy nanowire array electrode was catalytically more active than a pure platinum nanowire array electrode and the Pt-Ru nanowire array electrode may have good potential for applications in portable fuel cell power sources.

  5. Digital holographic characterization of liquid microlenses array fabricated in electrode-less configuration

    NASA Astrophysics Data System (ADS)

    Miccio, L.; Vespini, V.; Grilli, S.; Paturzo, M.; Finizio, A.; De Nicola, S.; Ferraro, P.

    2009-06-01

    We show how thin liquid film on polar dielectric substrate can form an array of liquid micro-lenses. The effect is driven by the pyroelectric effect leading to a new concept in electro-wetting (EW). EW is a viable method for actuation of liquids in microfluidic systems and requires the design and fabrication of complex electrodes for suitable actuation of liquids. When compared to conventional electrowetting devices, the pyroelectric effect allowed to have an electrode-less and circuitless configuration. In our case the surface electric charge induced by the thermal stimulus is able to pattern selectively the surface wettability according to geometry of the ferroelectric domains micro-engineered into the lithium niobate crystal. We show that different geometries of liquid microlenses can be obtained showing also a tuneability of the focal lenses down to 1.6 mm. Thousand of liquid microlenses, each with 100 μm diameter, can be formed and actuated. Also different geometries such as hemi-cylindrical and toroidal liquid structures can be easily obtained. By means of a digital holography method, an accurate characterization of the micro-lenses curvature is performed and presented. The preliminary results concerning the imaging capability of the micro-lens array are also reported. Microlens array can find application in medical stereo-endoscopy, imaging, telecommunication and optical data storage too.

  6. Large current difference in Au-coated vertical silicon nanowire electrode array with functionalization of peptides

    PubMed Central

    2013-01-01

    Au-coated vertical silicon nanowire electrode array (VSNEA) was fabricated using a combination of bottom-up and top-down approaches by chemical vapor deposition and complementary metal-oxide-semiconductor process for biomolecule sensing. To verify the feasibility for the detection of biomolecules, Au-coated VSNEA was functionalized using peptides having a fluorescent probe. Cyclic voltammograms of the peptide-functionalized Au-coated VSNEA show a steady-state electrochemical current behavior. Because of the critically small dimension and vertically aligned nature of VSNEA, the current density of Au-coated VSNEA was dramatically higher than that of Au film electrodes. Au-coated VSNEA further showed a large current difference with and without peptides that was nine times more than that of Au film electrodes. These results indicate that Au-coated VSENA is highly effective device to detect peptides compared to conventional thin-film electrodes. Au-coated VSNEA can also be used as a divergent biosensor platform in many applications. PMID:24279451

  7. Large current difference in Au-coated vertical silicon nanowire electrode array with functionalization of peptides

    NASA Astrophysics Data System (ADS)

    Kim, Ilsoo; Kim, So-Eun; Han, Sanghun; Kim, Hyungsuk; Lee, Jaehyung; Jeong, Du-Won; Kim, Ju-Jin; Lim, Yong-beom; Choi, Heon-Jin

    2013-11-01

    Au-coated vertical silicon nanowire electrode array (VSNEA) was fabricated using a combination of bottom-up and top-down approaches by chemical vapor deposition and complementary metal-oxide-semiconductor process for biomolecule sensing. To verify the feasibility for the detection of biomolecules, Au-coated VSNEA was functionalized using peptides having a fluorescent probe. Cyclic voltammograms of the peptide-functionalized Au-coated VSNEA show a steady-state electrochemical current behavior. Because of the critically small dimension and vertically aligned nature of VSNEA, the current density of Au-coated VSNEA was dramatically higher than that of Au film electrodes. Au-coated VSNEA further showed a large current difference with and without peptides that was nine times more than that of Au film electrodes. These results indicate that Au-coated VSENA is highly effective device to detect peptides compared to conventional thin-film electrodes. Au-coated VSNEA can also be used as a divergent biosensor platform in many applications.

  8. Three-dimensional nanotube electrode arrays for hierarchical tubular structured high-performance pseudocapacitors

    NASA Astrophysics Data System (ADS)

    Gao, Yuan; Lin, Yuanjing; Chen, Jiaqi; Lin, Qingfeng; Wu, Yue; Su, Wenjun; Wang, Wenli; Fan, Zhiyong

    2016-07-01

    Ordered three-dimensional (3-D) tubular arrays are highly attractive candidates for high performance pseudocapacitor electrodes. Here, we report 3-D fluorine doped tin oxide (FTO) tubular arrays fabricated by a cost-effective ultrasonic spray pyrolysis (USP) method in anodic aluminum oxide (AAO) channels with high uniformity. The large surface area of such a structure leads to remarkable surface area enhancement up to 51.8 times compared to a planar structure. Combining with electrochemically deposited manganese dioxide (MnO2) nanoflakes on the inner side wall of the FTO nanotubes, the unique hierarchical tubular structured pseudocapacitor electrode demonstrated the highest areal capacitance of 193.8 mF cm-2 at the scan rate of 5 mV s-1 and 184 mF cm-2 at the discharge current density of 0.6 mA cm-2, which is 18.5 times that of a planar electrode. And it also showed a volumetric capacitance of 112.6 F cm-3 at the scan rate of 5 mV s-1 and 108.8 F cm-3 at the discharge current density of 0.6 mA cm-2. In addition, the cyclic stability test also indicated that a nanostructured pseudocapacitive electrode has a much larger capacitance retention after 3000 cycles of the charge-discharge process compared with a planar electrode, primarily due to the mechanical stability of the nanostructure. Moreover, pseudocapacitor device fabrication based on such electrodes shows the volumetric capacitance of 17.5 F cm-3, and the highest specific energy of 1.56 × 10-3 Wh cm-3. With the merit of facile fabrication procedures and largely enhanced electrochemical performance, such a 3-D structure has high potency for energy storage systems for a wide range of practical applications.Ordered three-dimensional (3-D) tubular arrays are highly attractive candidates for high performance pseudocapacitor electrodes. Here, we report 3-D fluorine doped tin oxide (FTO) tubular arrays fabricated by a cost-effective ultrasonic spray pyrolysis (USP) method in anodic aluminum oxide (AAO) channels with

  9. Sensitive and Selective Detection of HIV-1 RRE RNA Using Vertical Silicon Nanowire Electrode Array.

    PubMed

    Lee, Jaehyung; Hong, Min-Ho; Han, Sanghun; Na, Jukwan; Kim, Ilsoo; Kwon, Yong-Joon; Lim, Yong-Beom; Choi, Heon-Jin

    2016-12-01

    In this study, HIV-1 Rev response element (RRE) RNA was detected via an Au-coated vertical silicon nanowire electrode array (VSNEA). The VSNEA was fabricated by combining bottom-up and top-down approaches and then immobilized by artificial peptides for the recognition of HIV-1 RRE. Differential pulse voltammetry (DPV) analysis was used to measure the electrochemical response of the peptide-immobilized VSNEA to the concentration and types of HIV-1 RRE RNA. DPV peaks showed linearity to the concentration of RNA with a detection limit down to 1.513 fM. It also showed the clear different peaks to the mutated HIV-1 RRE RNA. The high sensitivity and selectivity of VSNEA for the detection of HIV-1 RRE RNA may be attributed to the high surface-to-volume ratio and total overlap diffusion mode of ions of the one-dimensional nanowire electrodes. PMID:27448026

  10. Sensitive and Selective Detection of HIV-1 RRE RNA Using Vertical Silicon Nanowire Electrode Array

    NASA Astrophysics Data System (ADS)

    Lee, Jaehyung; Hong, Min-Ho; Han, Sanghun; Na, Jukwan; Kim, Ilsoo; Kwon, Yong-Joon; Lim, Yong-beom; Choi, Heon-Jin

    2016-07-01

    In this study, HIV-1 Rev response element (RRE) RNA was detected via an Au-coated vertical silicon nanowire electrode array (VSNEA). The VSNEA was fabricated by combining bottom-up and top-down approaches and then immobilized by artificial peptides for the recognition of HIV-1 RRE. Differential pulse voltammetry (DPV) analysis was used to measure the electrochemical response of the peptide-immobilized VSNEA to the concentration and types of HIV-1 RRE RNA. DPV peaks showed linearity to the concentration of RNA with a detection limit down to 1.513 fM. It also showed the clear different peaks to the mutated HIV-1 RRE RNA. The high sensitivity and selectivity of VSNEA for the detection of HIV-1 RRE RNA may be attributed to the high surface-to-volume ratio and total overlap diffusion mode of ions of the one-dimensional nanowire electrodes.

  11. The origin of spontaneous synchronized burst in cultured neuronal networks based on multi-electrode arrays.

    PubMed

    Chen, Chuanping; Chen, Lin; Lin, Yunsheng; Zeng, Shaoqun; Luo, Qingming

    2006-08-01

    Many neural networks in mammalian central nervous system (CNS) fire single spike and complex spike burst. In fact, the conditions for triggering burst are not well understood. In the paper multi-electrode arrays (MEA) are used to record the spontaneous electrophysiological activities of cultured rat hippocampal neuronal network for a long time. After about 3 weeks culture, a transition from single spike to burst is observed in several networks. All of these spikes fire quickly before burst begins. The firing rate during the burst is lower than that just before the burst, but differences of inter-spike intervals (ISIs) between two firing patterns are not clear. Moreover, the electrical activities on neighboring electrodes show strong synchrony during the burst activities. In a word, the generation of the burst requires that network should have a sufficient level of excitation as well as a balance of synaptic inhibition. PMID:16533555

  12. Liquid-crystal micro-lens array with two-divided and tetragonally hole-patterned electrodes.

    PubMed

    Kawamura, Marenori; Nakamura, Kento; Sato, Susumu

    2013-11-01

    We propose a liquid crystal (LC) micro-lens array with the structure of two-divided and tetragonally hole-patterned electrodes. Each LC cell in the lens array behaves like cylindrical or spherical lens properties by electrically adjusting the applied voltages. The LC micro-lens array is useful for tuning optical properties such a focal length and deflection angle of a light emitting diode (LED) illumination system. PMID:24216873

  13. Cochlear implantation through the round window with a straight slotted electrode array: optimizing the surgical procedure.

    PubMed

    Mom, Thierry; Bachy, Aurélie; Houette, Aubry; Pavier, Yoann; Pastourel, Rémy; Gabrillargues, Jean; Saroul, Nicolas; Gilain, Laurent; Avan, Paul

    2016-04-01

    The question addressed here is how optimizing the quality of insertion through the round window with the lower morbidity, when using a straight and slotted electrode array of regular length. This retrospective analysis includes all cases implanted with a cochlear implant Digisonic SP (Neurelec-Oticon Medical) since 2004. We checked the operative charts, the depth of insertion, and the follow-up. For comparisons, contingency tables were used and a Chi-square test was performed. A p value <0.05 was considered significant. 126 cases of patients with non-malformed cochleas were implanted through the round window. The mean age was 53.8 ± 16.2 for adults and 3.6 ± 2.6 for children (24 cases). The mean follow-up was 33 ± 22 months. The straight electrode array had either a square or a soft pointed tip (n = 84). Full insertion was achieved in 79 out of 84 cases with a soft tip vs. 18 out of 42 square tips (χ (2) = 41.41, DOF = 1, p < 0.0001). Two cases were stuck at the round window niche by a prominent crista fenestrae. In all cases but one, the chorda tympany was preserved. In one case, a misrouting to the vestibule required a revision surgery. Implantation through the round window with a straight and slotted electrode array with a soft tip (Digisonic SP, Neurelec-Oticon Medical) can lead to a full insertion in 94 % of cases. Drilling out a prominent crista fenestrae is recommended. PMID:25894503

  14. Unexpected Radiologic Findings for a Casting Type of Radiolucent Colorectal Foreign Body Composed of Polyurethane Foam

    PubMed Central

    Tamamoto, Fumihiko; Ogawa, Shoichi; Sano, Maiko; Yoshimura, Tetsunori; Nozaki, Miwako

    2016-01-01

    Radiologic diagnosis of colorectal foreign bodies is usually not very difficult, because inserted materials are often clearly visible on plain abdominal radiographs. However, when they are radiolucent, a plain abdominal radiograph has been reported to be useless. As radiolucent colorectal foreign bodies appear as radiolucent artificial contours or air-trapped materials in the pelvis, almost always the diagnosis itself can be made by careful evaluation of plain abdominal radiographs. We encountered a case of casting type of radiolucent colorectal foreign body formed from polyurethane foam. It presented us with unexpected radiologic findings and led to diagnostic difficulties. PMID:27213072

  15. Unexpected Radiologic Findings for a Casting Type of Radiolucent Colorectal Foreign Body Composed of Polyurethane Foam.

    PubMed

    Sanjo, Emi; Tamamoto, Fumihiko; Ogawa, Shoichi; Sano, Maiko; Yoshimura, Tetsunori; Nozaki, Miwako

    2016-01-01

    Radiologic diagnosis of colorectal foreign bodies is usually not very difficult, because inserted materials are often clearly visible on plain abdominal radiographs. However, when they are radiolucent, a plain abdominal radiograph has been reported to be useless. As radiolucent colorectal foreign bodies appear as radiolucent artificial contours or air-trapped materials in the pelvis, almost always the diagnosis itself can be made by careful evaluation of plain abdominal radiographs. We encountered a case of casting type of radiolucent colorectal foreign body formed from polyurethane foam. It presented us with unexpected radiologic findings and led to diagnostic difficulties. PMID:27213072

  16. Wireless electrochemiluminescence bipolar electrode array for visualized genotyping of single nucleotide polymorphism.

    PubMed

    Khoshfetrat, Seyyed Mehdi; Ranjbari, Mitra; Shayan, Mohsen; Mehrgardi, Masoud A; Kiani, Abolfazl

    2015-08-18

    The development of simple, inexpensive, hand-held, user-friendly biosensor for high throughput and multiplexed genotyping of various single nucleotide polymorphisms (SNPs) in a single run experiment by a nonspecialist user is the main challenge in the analysis of DNA. Visualizing the signal and possibility to monitor SNPs by a digital camera opens a new horizon for the routine applications. In the present manuscript, a novel wireless electrochemiluminescence (ECL) DNA array is introduced for the visualized genotyping of different SNPs on the basis of ECL of luminol/hydrogen peroxide system on a bipolar electrode (BPE) array platform. After modification of anodic poles of the array with the DNA probe and its hybridization with the targets, genotyping of various SNPs is carried out by exposing the array to different monobase modified luminol-platinum nanoparticles (M-L-PtNPs). Upon the hybridization of M-L-PtNPs to mismatch sites, the ECL of luminol is followed using a photomultiplier tube (PMT) or digital camera and the images are analyzed by ImageJ software. This biosensor can detect even thermodynamically stable SNP (G-T mismatches) in the range of 2-600 pM. Also, by combining the advantages of BPE and the high visual sensitivity of ECL, it could be easily expected to achieve sensitive screening of different SNPs. The present biosensor demonstrates the capability for the discrimination between PCR products of normal, heterozygous, and homozygous beta thalassemia genetic disorders. PMID:26176414

  17. Curved Microneedle Array-Based sEMG Electrode for Robust Long-Term Measurements and High Selectivity.

    PubMed

    Kim, Minjae; Kim, Taewan; Kim, Dong Sung; Chung, Wan Kyun

    2015-01-01

    Surface electromyography is widely used in many fields to infer human intention. However, conventional electrodes are not appropriate for long-term measurements and are easily influenced by the environment, so the range of applications of sEMG is limited. In this paper, we propose a flexible band-integrated, curved microneedle array electrode for robust long-term measurements, high selectivity, and easy applicability. Signal quality, in terms of long-term usability and sensitivity to perspiration, was investigated. Its motion-discriminating performance was also evaluated. The results show that the proposed electrode is robust to perspiration and can maintain a high-quality measuring ability for over 8 h. The proposed electrode also has high selectivity for motion compared with a commercial wet electrode and dry electrode. PMID:26153773

  18. Curved Microneedle Array-Based sEMG Electrode for Robust Long-Term Measurements and High Selectivity

    PubMed Central

    Kim, Minjae; Kim, Taewan; Kim, Dong Sung; Chung, Wan Kyun

    2015-01-01

    Surface electromyography is widely used in many fields to infer human intention. However, conventional electrodes are not appropriate for long-term measurements and are easily influenced by the environment, so the range of applications of sEMG is limited. In this paper, we propose a flexible band-integrated, curved microneedle array electrode for robust long-term measurements, high selectivity, and easy applicability. Signal quality, in terms of long-term usability and sensitivity to perspiration, was investigated. Its motion-discriminating performance was also evaluated. The results show that the proposed electrode is robust to perspiration and can maintain a high-quality measuring ability for over 8 h. The proposed electrode also has high selectivity for motion compared with a commercial wet electrode and dry electrode. PMID:26153773

  19. Manipulating location, polarity, and outgrowth length of neuron-like pheochromocytoma (PC-12) cells on patterned organic electrode arrays.

    PubMed

    Hsiao, Yu-Sheng; Lin, Chung-Chih; Hsieh, Hsin-Jui; Tsai, Shih-Min; Kuo, Chiung-Wen; Chu, Chih-Wei; Chen, Peilin

    2011-11-01

    In this manuscript, we describe a biocompatible organic electrode system, comprising poly(3,4-ethylenedioxythiophene) (PEDOT) microelectrode arrays on indium tin oxide (ITO) glass, that can be used to regulate the neuron type, location, polarity, and outgrown length of neuron-like cells (PC-12). We fabricated a PEDOT microelectrode array with four different sizes (flat; 20, 50, and 100 μm) through electrochemical polymerization. Extracellular matrix proteins absorbed well on these organic electrodes; cells absorbed selectively on the organic electrodes when we used polyethylene oxide/polypropylene oxide/polyethylene oxide triblock copolymers (PEO/PPO/PEO, Pluronic™ F108) as the anti-adhesive coating. In this system, the neurite polarities and neuron types could be manipulated by varying the width of the PEDOT microelectrode arrays. On the unpatterned PEDOT electrode, PC-12 cells were randomly polarized, with approximately 80% having multi-polar cell types. In contrast, when we cultured PC-12 cells on the 20 μm wide PEDOT line array, the neurites aligned along the direction of the organic electrodes, with the percentage of uni- and bipolar PC-12 cells increasing to greater than 90%. The outgrowth of neurites on the microelectrodes was promoted by ~60% with an applied electrical stimulation. Therefore, these electroactive PEDOT microelectrode arrays have potential for use in tissue engineering related to the development and regeneration of mammalian nervous systems. PMID:21922117

  20. An electrocorticographic electrode array for simultaneous recording from medial, lateral, and intrasulcal surface of the cortex in macaque monkeys

    PubMed Central

    Fukushima, Makoto; Saunders, Richard C.; Mullarkey, Matthew; Doyle, Alexandra M.; Mishkin, Mortimer; Fujii, Naotaka

    2014-01-01

    Background Electrocorticography (ECoG) permits recording electrical field potentials with high spatiotemporal resolution over a large part of the cerebral cortex. Application of chronically implanted ECoG arrays in animal models provides an opportunity to investigate global spatiotemporal neural patterns and functional connectivity systematically under various experimental conditions. Although ECoG is conventionally used to cover the gyral cortical surface, recent studies have shown the feasibility of intrasulcal ECoG recordings in macaque monkeys. New Method Here we developed a new ECoG array to record neural activity simultaneously from much of the medial and lateral cortical surface of a single hemisphere, together with the supratemporal plane (STP) of the lateral sulcus in macaque monkeys. The ECoG array consisted of 256 electrodes for bipolar recording at 128 sites. Results We successfully implanted the ECoG array in the left hemisphere of three rhesus monkeys. The electrodes in the auditory and visual cortex detected robust event related potentials to auditory and visual stimuli, respectively. Bipolar recording from adjacent electrode pairs effectively eliminated chewing artifacts evident in monopolar recording, demonstrating the advantage of using the ECoG array under conditions that generate significant movement artifacts. Comparison with Existing Methods Compared with bipolar ECoG arrays previously developed for macaque monkeys, this array significantly expands the number of cortical target areas in gyral and intralsulcal cortex. Conclusions This new ECoG array provides an opportunity to investigate global network interactions among gyral and intrasulcal cortical areas. PMID:24972186

  1. Recording sensory and motor information from peripheral nerves with Utah Slanted Electrode Arrays.

    PubMed

    Clark, Gregory A; Ledbetter, Noah M; Warren, David J; Harrison, Reid R

    2011-01-01

    Recording and stimulation via high-count penetrating microelectrode arrays implanted in peripheral nerves may help restore precise motor and sensory function after nervous system damage or disease. Although previous work has demonstrated safety and relatively successful stimulation for long-term implants of 100-electrode Utah Slanted Electrode Arrays (USEAs) in feline sciatic nerve [1], two major remaining challenges were 1) to maintain viable recordings of nerve action potentials long-term, and 2) to overcome contamination of unit recordings by myoelectric (EMG) activity in awake, moving animals. In conjunction with improvements to USEAs themselves, we have redesigned several aspects of our USEA containment and connector systems. Although further increases in unit yield and long-term stability remain desirable, here we report considerable progress toward meeting both of these goals: We have successfully recorded unit activity from USEAs implanted intrafascicularly in sciatic nerve for periods up to 4 months (the terminal experimental time point), and we have developed a containment system that effectively eliminates or substantially reduces EMG contamination of unit recordings in the moving animal. In addition, we used a 100-channel wireless recording integrated circuit attached to implanted USEAs to transmit broadband or spike-threshold data from nerve. Neural data thusly obtained during imposed limb movements were decoded blindly to drive a virtual prosthetic limb in real time. These results support the possibility of using USEAs in peripheral nerves to provide motor control and cutaneous or proprioceptive sensory feedback in individuals after limb loss or spinal cord injury. PMID:22255372

  2. Pt-Pb nanowire array electrode for enzyme-free glucose detection.

    PubMed

    Bai, Yu; Sun, Yingying; Sun, Changqing

    2008-12-01

    Pt-Pb nanowire array was directly synthesized by electrochemical deposition of Pt-Pb alloy into the pores of microporous polycarbonate template and subsequent chemical etching of the template. The morphology and the composition of the Pt-Pb nanowires were characterized by scanning electron microscopy (SEM) and X-ray photoelectron spectroscopy (XPS), respectively. Cyclic voltammetry (CV) was used to evaluate the electrochemical performance of the Pt-Pb nanowire array electrode (Pt-PbNAE). Direct glucose oxidation on Pt-PbNAE was investigated in detail by discussing the effect of the structure and materials of the electrode on electrocatalytic oxidation of glucose. As a result, we found that the Pt-PbNAE with a three-dimensional structure exhibited high electrocatalytic activity to glucose oxidation in neutral condition and could be used for the development of nonenzymatic glucose sensor. To effectively avoid the interference coming from ascorbic acid, a negative potential of -0.20V was chosen for glucose detection, and the sensitivity of the sensor to glucose oxidation was 11.25 microAmM(-1)cm(-2) with a linearity up to 11 mM, and a detection limit of 8 microM (signal-to-noise ratio of 3). PMID:18619831

  3. Wall-like hierarchical metal oxide nanosheet arrays grown on carbon cloth for excellent supercapacitor electrodes.

    PubMed

    Huang, Zongyu; Zhang, Zhen; Qi, Xiang; Ren, Xiaohui; Xu, Guanghua; Wan, Pengbo; Sun, Xiaoming; Zhang, Han

    2016-07-21

    Recently, considerable efforts have been made to satisfy the future requirements of electrochemical energy storage using novel functional electrode materials. Binary transition metal oxides (BTMOs) possess multiple oxidation states that enable multiple redox reactions, showing higher supercapacitive properties than single component metal oxides. In this work, a facile hydrothermal method is provided for the synthesis of wall-like hierarchical metal oxide MMoO4 (M = Ni, Co) nanosheet arrays, which are directly grown on flexible carbon cloth for use as advanced binder-free electrodes for supercapacitors. By virtue of their intriguing structure, the resulted active material nanosheets with a high specific surface area can provide a large electroactive region, which could facilitate easy accession of electrolyte ions and fast charge transport, resulting in an enhanced electrochemical performance. Separately, the as-synthesized MMoO4 (M = Ni, Co) samples have exhibited superior specific capacitances (1483 F g(-1) of NiMoO4 and 452 F g(-1) of CoMoO4 at a current density of 2 A g(-1)), as well as excellent cycling stability (93.1% capacitance retention of NiMoO4 and 95.9% capacitance retention of CoMoO4 after 2000 cycles). The results show that the binder-free electrodes constructed by deposition of MMoO4 (M = Ni, Co) nanosheets on carbon cloth are promising candidates for the application of supercapacitors. PMID:27336591

  4. Imaging of CO2 plume scenarios in saline reservoirs by (non) optimized crosshole electrode arrays

    NASA Astrophysics Data System (ADS)

    Al Hagrey, S. A.; Strahser, M. H.; Rabbel, W.

    2009-12-01

    In the scope of the research project “CO2 MoPa” (modeling and parameterization of CO2 storage in deep saline formations for dimensions and risk analysis), one main task is to study the efficiency of electrical resistivity tomography in boreholes (BRT) in monitoring the subsurface distribution of CO2 sequestrated in deep saline reservoirs. Similar to ground surveys, BRT ones between a pair of borehole electrode arrays can be conducted in the tripotential quadrupole configurations of α, β and γ in vertical, lateral and horizontal modes. The circulating vertical mode is carried out within the same borehole (inhole) and between two boreholes (crosshole). The comprehensive dataset results from excluding the less stable inversion configurations from the whole set (of all possible independent non-reciprocal configurations). It should result in the best possible resolution. An optimized dataset takes into account the trade-off between spatial and temporal resolution of targets and processes. It has far less data size than the comprehensive one but almost the same resolution. Hagrey (2009) and Loke (pers. com.) extended four published 2D optimization algorithms of electrode arrays for ground surveys into BRT ones. Using an initial base dataset of the dipole-dipole configuration, the new configurations (from the remaining comprehensive dataset) with the largest increase in the model resolution matrix is added to the base dataset. After each iteration the number of arrays in the optimized dataset is increased and the procedure is repeated iteratively until the required data size is achieved. For BRT surveys between two vertical boreholes, ten (non)-standard and optimized configurations have been examined as a function of the multiparameters of, CO2 plume scenarios, burial depths, electrode configurations, aspect ratios, and forward and inversion setup constraints. In these 2.5D modeling studies problems of sharp and gradual boundaries for plume scenarios and

  5. Microfabricated electrospray emitter arrays with integrated extractor and accelerator electrodes for the propulsion of small spacecraft

    NASA Astrophysics Data System (ADS)

    Dandavino, S.; Ataman, C.; Ryan, C. N.; Chakraborty, S.; Courtney, D.; Stark, J. P. W.; Shea, H.

    2014-07-01

    Microfabricated electrospray thrusters could revolutionize the spacecraft industry by providing efficient propulsion capabilities to micro and nano satellites (1-100 kg). We present the modeling, design, fabrication and characterization of a new generation of devices, for the first time integrating in the fabrication process individual accelerator electrodes capable of focusing and accelerating the emitted sprays. Integrating these electrodes is a key milestone in the development of this technology; in addition to increasing the critical performance metrics of thrust, specific impulse and propulsive efficiency, the accelerators enable a number of new system features such as power tuning and thrust vectoring and balancing. Through microfabrication, we produced high density arrays (213 emitters cm-2) of capillary emitters, assembling them at wafer-level with an extractor/accelerator electrode pair separated by micro-sandblasted glass. Through IV measurements, we could confirm that acceleration could be decoupled from the extraction of the spray—an important element towards the flexibility of this technology. We present the largest reported internally fed microfabricated arrays operation, with 127 emitters spraying in parallel, for a total beam of 10-30 µA composed by 95% of ions. Effective beam focusing was also demonstrated, with plume half-angles being reduced from approximately 30° to 15° with 2000 V acceleration. Based on these results, we predict, with 3000 V acceleration, thrust per emitter of 38.4 nN, specific impulse of 1103 s and a propulsive efficiency of 22% with <1 mW/emitter power consumption.

  6. Image sensors with electrically tunable spatial resolution based on liquid crystal microlens array with three-layered patterned electrode

    NASA Astrophysics Data System (ADS)

    Tong, Qing; Zhang, Xinyu; Sang, Hongshi; Zhang, Tianxu; Xie, Changsheng

    2013-10-01

    The liquid crystal (LC) device with the circle aperture electrode can be used as a convex lens. The index of refraction of the LC lens can be easily changed by the voltage signal; the arrayed LC lens can be used in the imaging sensors. Comparing with the traditional optical lens, the LC lens has a more effective architecture. In this paper, we present an imaging sensor with a new type LC structure composed of three layers of top electrodes and a joint bottom electrode, and simulating the tunable spatial resolution architecture carried out by applying voltage signal over different ITO electrode in LC lenses coupled with arrayed imaging sensors. From the result of the simulation, we can find that changing the spatial resolution by our architecture can be achieved.

  7. Enhancement of non-invasive recording of electroenterogram by means of a flexible array of concentric ring electrodes.

    PubMed

    Garcia-Casado, J; Zena-Gimenez, V; Prats-Boluda, G; Ye-Lin, Y

    2014-03-01

    Monitoring intestinal myoelectrical activity by electroenterogram (EEnG) would be of great clinical interest for diagnosing gastrointestinal pathologies and disorders. However, surface EEnG recordings are of very low amplitude and can be severely affected by baseline drifts and respiratory and electrocardiographic (ECG) interference. In this work, a flexible array of concentric ring electrodes was developed and tested to determine whether it can provide surface EEnG signals of better quality than bipolar recordings from conventional disc electrodes. With this aim, sixteen healthy subjects in a fasting state (>8 h) underwent recording. The capability of detecting intestinal pacemaker activity (slow wave) and the influence of physiological interferences were studied. The signals obtained from the concentric ring electrodes proved to be more robust to ECG and respiratory interference than those from conventional disc electrodes. The results also show that intestinal EEnG components such as the slow wave can be more easily identified by the proposed system based on a flexible array of concentric ring electrodes. The developed active electrode array could be a very valuable tool for non-invasive diagnosis of disease states such as ischemia and motility disorders of the small bowel which are known to alter the normal enteric slow wave activity. PMID:24232692

  8. Minimally invasive endovascular stent-electrode array for high-fidelity, chronic recordings of cortical neural activity.

    PubMed

    Oxley, Thomas J; Opie, Nicholas L; John, Sam E; Rind, Gil S; Ronayne, Stephen M; Wheeler, Tracey L; Judy, Jack W; McDonald, Alan J; Dornom, Anthony; Lovell, Timothy J H; Steward, Christopher; Garrett, David J; Moffat, Bradford A; Lui, Elaine H; Yassi, Nawaf; Campbell, Bruce C V; Wong, Yan T; Fox, Kate E; Nurse, Ewan S; Bennett, Iwan E; Bauquier, Sébastien H; Liyanage, Kishan A; van der Nagel, Nicole R; Perucca, Piero; Ahnood, Arman; Gill, Katherine P; Yan, Bernard; Churilov, Leonid; French, Christopher R; Desmond, Patricia M; Horne, Malcolm K; Kiers, Lynette; Prawer, Steven; Davis, Stephen M; Burkitt, Anthony N; Mitchell, Peter J; Grayden, David B; May, Clive N; O'Brien, Terence J

    2016-03-01

    High-fidelity intracranial electrode arrays for recording and stimulating brain activity have facilitated major advances in the treatment of neurological conditions over the past decade. Traditional arrays require direct implantation into the brain via open craniotomy, which can lead to inflammatory tissue responses, necessitating development of minimally invasive approaches that avoid brain trauma. Here we demonstrate the feasibility of chronically recording brain activity from within a vein using a passive stent-electrode recording array (stentrode). We achieved implantation into a superficial cortical vein overlying the motor cortex via catheter angiography and demonstrate neural recordings in freely moving sheep for up to 190 d. Spectral content and bandwidth of vascular electrocorticography were comparable to those of recordings from epidural surface arrays. Venous internal lumen patency was maintained for the duration of implantation. Stentrodes may have wide ranging applications as a neural interface for treatment of a range of neurological conditions. PMID:26854476

  9. Behavioral and cellular consequences of high-electrode count Utah Arrays chronically implanted in rat sciatic nerve

    NASA Astrophysics Data System (ADS)

    Wark, H. A. C.; Mathews, K. S.; Normann, R. A.; Fernandez, E.

    2014-08-01

    Objective. Before peripheral nerve electrodes can be used for the restoration of sensory and motor functions in patients with neurological disorders, the behavioral and histological consequences of these devices must be investigated. These indices of biocompatibility can be defined in terms of desired functional outcomes; for example, a device may be considered for use as a therapeutic intervention if the implanted subject retains functional neurons post-implantation even in the presence of a foreign body response. The consequences of an indwelling device may remain localized to cellular responses at the device-tissue interface, such as fibrotic encapsulation of the device, or they may affect the animal more globally, such as impacting behavioral or sensorimotor functions. The objective of this study was to investigate the overall consequences of implantation of high-electrode count intrafascicular peripheral nerve arrays, High Density Utah Slanted Electrode Arrays (HD-USEAs; 25 electrodes mm-2). Approach. HD-USEAs were implanted in rat sciatic nerves for one and two month periods. We monitored wheel running, noxious sensory paw withdrawal reflexes, footprints, nerve morphology and macrophage presence at the tissue-device interface. In addition, we used a novel approach to contain the arrays in actively behaving animals that consisted of an organic nerve wrap. A total of 500 electrodes were implanted across all ten animals. Main results. The results demonstrated that chronic implantation (⩽8 weeks) of HD-USEAs into peripheral nerves can evoke behavioral deficits that recover over time. Morphology of the nerve distal to the implantation site showed variable signs of nerve fiber degeneration and regeneration. Cytology adjacent to the device-tissue interface also showed a variable response, with some electrodes having many macrophages surrounding the electrodes, while other electrodes had few or no macrophages present. This variability was also seen along the length

  10. Performance assessments of vertically aligned carbon nanotubes multi-electrode arrays using Cath.a-differentiated (CAD) cells

    NASA Astrophysics Data System (ADS)

    Jeong, Du Won; Jung, Jongjin; Kim, Gook Hwa; Yang, Cheol-Soo; Kim, Ju Jin; Jung, Sang Don; Lee, Jeong-O.

    2015-08-01

    In this work, Cath.a-differentiated (CAD) cells were used in place of primary neuronal cells to assess the performance of vertically aligned carbon nanotubes (VACNTs) multi-electrode arrays (MEA). To fabricate high-performance MEA, VACNTs were directly grown on graphene/Pt electrodes via plasma enhanced chemical deposition technique. Here, graphene served as an intermediate layer lowering contact resistance between VACNTs and Pt electrode. In order to lower the electrode impedance and to enhance the cell adhesion, VACNTs-MEAs were treated with UV-ozone for 20 min. Impedance of VACNTs electrode at 1 kHz frequency exhibits a reasonable value (110 kΩ) for extracellular signal recording, and the signal to noise ratio the is good enough to measure low signal amplitude (15.7). Spontaneous firing events from CAD cells were successfully measured with VACNTs MEAs that were also found to be surprisingly robust toward the biological interactions.

  11. Performance assessments of vertically aligned carbon nanotubes multi-electrode arrays using Cath.a-differentiated (CAD) cells.

    PubMed

    Jeong, Du Won; Jung, Jongjin; Kim, Gook Hwa; Yang, Cheol-Soo; Kim, Ju Jin; Jung, Sang Don; Lee, Jeong-O

    2015-08-21

    In this work, Cath.a-differentiated (CAD) cells were used in place of primary neuronal cells to assess the performance of vertically aligned carbon nanotubes (VACNTs) multi-electrode arrays (MEA). To fabricate high-performance MEA, VACNTs were directly grown on graphene/Pt electrodes via plasma enhanced chemical deposition technique. Here, graphene served as an intermediate layer lowering contact resistance between VACNTs and Pt electrode. In order to lower the electrode impedance and to enhance the cell adhesion, VACNTs-MEAs were treated with UV-ozone for 20 min. Impedance of VACNTs electrode at 1 kHz frequency exhibits a reasonable value (110 kΩ) for extracellular signal recording, and the signal to noise ratio the is good enough to measure low signal amplitude (15.7). Spontaneous firing events from CAD cells were successfully measured with VACNTs MEAs that were also found to be surprisingly robust toward the biological interactions. PMID:26222018

  12. Ag nanoparticle-deposited TiO2 nanotube arrays for electrodes of Dye-sensitized solar cells

    NASA Astrophysics Data System (ADS)

    Kawamura, Go; Ohmi, Hayato; Tan, Wai Kian; Lockman, Zainovia; Muto, Hiroyuki; Matsuda, Atsunori

    2015-05-01

    Dye-sensitized solar cells composed of a photoanode of Ag nanoparticle (NP)-deposited TiO2 nanotube (TNT) arrays were fabricated. The TNT arrays were prepared by anodizing Ti films on fluorine-doped tin oxide (FTO)-coated glass substrates. Efficient charge transportation through the ordered nanostructure of TNT arrays should be carried out compared to conventional particulate TiO2 electrodes. However, it has been a big challenge to grow TNT arrays on FTO glass substrates with the lengths needed for sufficient light-harvesting (tens of micrometers). In this work, we deposited Ag nanoparticles (NPs) on the wall of TNT arrays to enhance light-harvesting property. Dye-sensitized solar cells with these Ag NP-deposited TNT arrays yielded a higher power conversion efficiency (2.03 %) than those without Ag NPs (1.39 %).

  13. Innervation zones of fasciculating motor units: observations by a linear electrode array

    PubMed Central

    Jahanmiri-Nezhad, Faezeh; Barkhaus, Paul E.; Rymer, William Z.; Zhou, Ping

    2015-01-01

    This study examines the innervation zone (IZ) in the biceps brachii muscle in healthy subjects and those with amyotrophic lateral sclerosis (ALS) using a 20-channel linear electromyogram (EMG) electrode array. Raster plots of individual waveform potentials were studied to estimate the motor unit IZ. While this work mainly focused on fasciculation potentials (FPs), a limited number of motor unit potentials (MUPs) from voluntary activity of 12 healthy and seven ALS subjects were also examined. Abnormal propagation of MUPs and scattered IZs were observed in fasciculating units, compared with voluntarily activated MUPs in healthy and ALS subjects. These findings can be related to muscle fiber reinnervation following motor neuron degeneration in ALS and the different origin sites of FPs compared with voluntary MUPs. PMID:26029076

  14. Simplified calibration of single-plunge bipolar electrode array for field measurement during defibrillation.

    PubMed

    Deale, O Carlton; Ng, Kwong T; Kim-Van Housen, Ellen J; Lerman, Bruce B

    2002-10-01

    In an earlier study, the authors presented a calibration technique for a triaxial bipolar electrode array (EA) that used 72 data points collected during a global sweep of the electric field vector relative to the EA axes. Although necessary for the initial characterization of the EAs, this data requirement has to be significantly reduced for the technique to become a practical tool. Therefore, in the present study, an analysis is performed to determine the relation between the number of data points used in the calibration and the mean root-mean-square error. The analysis shows that 18 data points can produce results nearly identical to those obtained with the 72-point calibration, thus reducing the required amount of data fourfold. PMID:12374347

  15. Wall-like hierarchical metal oxide nanosheet arrays grown on carbon cloth for excellent supercapacitor electrodes

    NASA Astrophysics Data System (ADS)

    Huang, Zongyu; Zhang, Zhen; Qi, Xiang; Ren, Xiaohui; Xu, Guanghua; Wan, Pengbo; Sun, Xiaoming; Zhang, Han

    2016-07-01

    Recently, considerable efforts have been made to satisfy the future requirements of electrochemical energy storage using novel functional electrode materials. Binary transition metal oxides (BTMOs) possess multiple oxidation states that enable multiple redox reactions, showing higher supercapacitive properties than single component metal oxides. In this work, a facile hydrothermal method is provided for the synthesis of wall-like hierarchical metal oxide MMoO4 (M = Ni, Co) nanosheet arrays, which are directly grown on flexible carbon cloth for use as advanced binder-free electrodes for supercapacitors. By virtue of their intriguing structure, the resulted active material nanosheets with a high specific surface area can provide a large electroactive region, which could facilitate easy accession of electrolyte ions and fast charge transport, resulting in an enhanced electrochemical performance. Separately, the as-synthesized MMoO4 (M = Ni, Co) samples have exhibited superior specific capacitances (1483 F g-1 of NiMoO4 and 452 F g-1 of CoMoO4 at a current density of 2 A g-1), as well as excellent cycling stability (93.1% capacitance retention of NiMoO4 and 95.9% capacitance retention of CoMoO4 after 2000 cycles). The results show that the binder-free electrodes constructed by deposition of MMoO4 (M = Ni, Co) nanosheets on carbon cloth are promising candidates for the application of supercapacitors.Recently, considerable efforts have been made to satisfy the future requirements of electrochemical energy storage using novel functional electrode materials. Binary transition metal oxides (BTMOs) possess multiple oxidation states that enable multiple redox reactions, showing higher supercapacitive properties than single component metal oxides. In this work, a facile hydrothermal method is provided for the synthesis of wall-like hierarchical metal oxide MMoO4 (M = Ni, Co) nanosheet arrays, which are directly grown on flexible carbon cloth for use as advanced binder

  16. Electrochemical signal amplification for immunosensor based on 3D interdigitated array electrodes.

    PubMed

    Han, Donghoon; Kim, Yang-Rae; Kang, Chung Mu; Chung, Taek Dong

    2014-06-17

    We devised an electrochemical redox cycling based on three-dimensional interdigitated array (3D IDA) electrodes for signal amplification to enhance the sensitivity of chip-based immunosensors. The 3D IDA consists of two closely spaced parallel indium tin oxide (ITO) electrodes that are positioned not only on the bottom but also the ceiling, facing each other along a microfluidic channel. We investigated the signal intensities from various geometric configurations: Open-2D IDA, Closed-2D IDA, and 3D IDA through electrochemical experiments and finite-element simulations. The 3D IDA among the four different systems exhibited the greatest signal amplification resulting from efficient redox cycling of electroactive species confined in the microchannel so that the faradaic current was augmented by a factor of ∼100. We exploited the enhanced sensitivity of the 3D IDA to build up a chronocoulometric immunosensing platform based on the sandwich enzyme-linked immunosorbent assay (ELISA) protocol. The mouse IgGs on the 3D IDA showed much lower detection limits than on the Closed-2D IDA. The detection limit for mouse IgG measured using the 3D IDA was ∼10 fg/mL, while it was ∼100 fg/mL for the Closed-2D IDA. Moreover, the proposed immunosensor system with the 3D IDA successfully worked for clinical analysis as shown by the sensitive detection of cardiac troponin I in human serum down to 100 fg/mL. PMID:24842332

  17. Hybrid tandem solar cell enhanced by a metallic hole-array as the intermediate electrode.

    PubMed

    Zhang, Xuanru; Huang, Qiuping; Hu, Jigang; Knize, Randy J; Lu, Yalin

    2014-10-20

    A metallic hole-array structure was inserted into a tandem solar cell structure as an intermediate electrode, which allows a further fabrication of a novel and efficient hybrid organic-inorganic tandem solar cell. The inserted hole-array layer reflects the higher-energy photons back to the top cell, and transmits lower-energy photons to the bottom cell via the extraordinary optical transmission (EOT) effect. In this case light absorption in both top and bottom subcells can be simultaneously enhanced via both structural and material optimizations. Importantly, this new design could remove the constraints of requiring lattice-matching and current-matching between the used two cascaded subcells in a conventional tandem cell structure, and therefore, the tunnel junction could be no longer required. As an example, a novel PCBM/CIGS tandem cell was designed and investigated. A systematic modeling study was made on the structural parameter tuning, with the period ranging from a few hundreds nanometers to over one micrometer. Surface plasmon polaritons, magnetic plasmon polaritons, localized surface plasmons, and optical waveguide modes were found to participate in the EOT and the light absorption enhancement. Impressively, more than 40% integrated power enhancement can be achieved in a variable structural parameter range. PMID:25607297

  18. Three-Dimensional Microcavity Array Electrodes for High-Capacitance All-Solid-State Flexible Microsupercapacitors.

    PubMed

    Maeng, Jimin; Kim, Young-Joon; Meng, Chuizhou; Irazoqui, Pedro P

    2016-06-01

    We report novel three-dimensional (3D) microcavity array electrodes for high-capacitance all-solid-state microsupercapactiors. The microcavity arrays are formed in a polymer substrate via a plasma-assisted reactive ion etching (RIE) process and provide extra sidewall surface areas on which the active materials are grown in the form of nanofibers. This 3D structure leads to an increase in the areal capacitance by a factor of 2.56 for a 15-μm-deep cavity etching, agreeing well with the prediction. The fabricated microsupercapactiors exhibit a maximum areal capacitance of 65.1 mF cm(-2) (a volumetric capacitance of 93.0 F cm(-3)) and an energy density of 0.011 mWh cm(-2) (a volumetric energy density of 16.4 mWh cm(-3)) which substantially surpass previously reported values for all-solid-state flexible microsupercapacitors. The devices show good electrochemical stability under extended voltammetry cycles and bending cycles. It is demonstrated that they can sustain a radio frequency (rf) microsystem in a temporary absence of a power supply. These results suggest the potential utility of our 3D microsupercapactiors as miniaturized power sources in wearable and implantable medical devices. PMID:27176134

  19. Multi-electrode Array Recordings of Human Epileptic Postoperative Cortical Tissue

    PubMed Central

    Dossi, Elena; Blauwblomme, Thomas; Nabbout, Rima; Huberfeld, Gilles; Rouach, Nathalie

    2014-01-01

    Epilepsy, affecting about 1% of the population, comprises a group of neurological disorders characterized by the periodic occurrence of seizures, which disrupt normal brain function. Despite treatment with currently available antiepileptic drugs targeting neuronal functions, one third of patients with epilepsy are pharmacoresistant. In this condition, surgical resection of the brain area generating seizures remains the only alternative treatment. Studying human epileptic tissues has contributed to understand new epileptogenic mechanisms during the last 10 years. Indeed, these tissues generate spontaneous interictal epileptic discharges as well as pharmacologically-induced ictal events which can be recorded with classical electrophysiology techniques. Remarkably, multi-electrode arrays (MEAs), which are microfabricated devices embedding an array of spatially arranged microelectrodes, provide the unique opportunity to simultaneously stimulate and record field potentials, as well as action potentials of multiple neurons from different areas of the tissue. Thus MEAs recordings offer an excellent approach to study the spatio-temporal patterns of spontaneous interictal and evoked seizure-like events and the mechanisms underlying seizure onset and propagation. Here we describe how to prepare human cortical slices from surgically resected tissue and to record with MEAs interictal and ictal-like events ex vivo. PMID:25407747

  20. Compliant bipolar electrostatic gripper with micropillar electrodes array for manipulation at macroscale

    NASA Astrophysics Data System (ADS)

    Dhelika, Radon; Hemthavy, Pasomphone; Takahashi, Kunio; Saito, Shigeki

    2016-05-01

    A compliant electrostatic gripper with bipolar voltage polarity for a pick-and-place manipulation is presented. The compliance, realized by the introduction of an array of micropillars which act as the electrode, extends the application of electrostatic-based gripper to manipulating fragile, rough-surfaced dielectric objects at macro scale. A prototype consisting of two arrays is developed by a chemical etching process. The experimental force is then compared with the theoretical force obtained from a simulation, showing a discrepancy between them. The sources of the discrepancy are analyzed to provide design insight for force improvement. To assess the reliability, the prototype is used for a manipulation demonstration of flat-surfaced paper. The result shows a good repeatability, and the necessary pick-up condition is confirmed. Subsequently, as the proof of the concept, another pick-up for rough-surfaced objects represented by a tissue paper with different roughness condition is also demonstrated. The effect of the rough surfaces to the generated forces is qualitatively discussed.

  1. A New Semi-Automatic Approach to Find Suitable Virtual Electrodes in Arrays Using an Interpolation Strategy

    PubMed Central

    Salchow, Christina; Valtin, Markus; Seel, Thomas; Schauer, Thomas

    2016-01-01

    Functional Electrical Stimulation via electrode arrays enables the user to form virtual electrodes (VEs) of dynamic shape, size, and position. We developed a feedback-control-assisted manual search strategy which allows the therapist to conveniently and continuously modify VEs to find a good stimulation area. This works for applications in which the desired movement consists of at least two degrees of freedom. The virtual electrode can be moved to arbitrary locations within the array, and each involved element is stimulated with an individual intensity. Meanwhile, the applied global stimulation intensity is controlled automatically to meet a predefined angle for one degree of freedom. This enables the therapist to concentrate on the remaining degree(s) of freedom while changing the VE position. This feedback-control-assisted approach aims to integrate the user’s opinion and the patient’s sensation. Therefore, our method bridges the gap between manual search and fully automatic identification procedures for array electrodes. Measurements in four healthy volunteers were performed to demonstrate the usefulness of our concept, using a 24-element array to generate wrist and hand extension. PMID:27478567

  2. Ultrasound in differential diagnosis of periapical radiolucencies: A radiohistopathological study

    PubMed Central

    Khambete, Neha; Kumar, Rahul

    2015-01-01

    Objectives: To evaluate the efficacy of ultrasound in differential diagnosis of periapical radiolucencies. Materials and Methods: Ten patients aged between 19 years and 40 years with periapical lesions associated with anterior maxillary or mandibular teeth were selected and consented for the study. Pre-operative periapical radiographs were obtained. Measurements and provisional diagnoses of the apical areas were made by two specialist observers on two separate occasions. Preoperative ultrasound examinations with Doppler flowmetry were then performed and the images assessed by two specialist observers for the size, contents, vascular supply and a provisional diagnosis made as to whether the lesion was a cyst or granuloma. Endodontic surgery was performed including curettage of the apical tissues to enable histopathological investigation, which provided the gold standard diagnosis. All measurements and findings were compared and statistically analyzed. Results: Total 10 lesions were identified in 10 patients. On periapical radiographs, lesions were readily identified but observers were unable to differentiate granuloma from cyst using either modality. Where sufficient buccal cortical bone had been resorbed, ultrasound imaging was simple but underestimated the size of the lesions compared with periapical radiographs. In all cases, the ultrasound diagnosis agreed with the histopathological gold standard. Conclusion: Ultrasonography (USG) can provide accurate information about the nature of intraosseous lesions of the jaws before any surgical procedure. It is proposed that USG with Doppler flowmetry can provide an additional diagnostic tool without invasive surgery, where treatment option is nonsurgical. PMID:25657525

  3. Electrochemical properties of high-power supercapacitors using ordered NiO coated Si nanowire array electrodes

    NASA Astrophysics Data System (ADS)

    Lu, Fang; Qiu, Mengchun; Qi, Xiang; Yang, Liwen; Yin, Jinjie; Hao, Guolin; Feng, Xiang; Li, Jun; Zhong, Jianxin

    2011-08-01

    Highly ordered NiO coated Si nanowire arrays are fabricated as electrode materials for electrochemical supercapacitors (ES) via depositing Ni on electroless-etched Si nanowires and subsequently annealing. The electrochemical tests reveal that the constructed electrode has superior electrical conductibility and more active sites per unit area for chemical reaction processes, thereby possessing good cycle stability, high specific capacity, and low internal resistance. The specific capacity is up to 787.5 F g-1 at a discharge current of 2.5 mA and decreases slightly with 4.039% loss after 500 cycles, while the equivalent internal resistance is ˜3.067 Ω. Owing to its favorable electrochemical performance, this ordered hybrid array nanostructure is a promising electrode material in future commercial ES.

  4. Microfluidic Device with Tunable Post Arrays and Integrated Electrodes for Studying Cellular Release

    PubMed Central

    Selimovic, Asmira; Erkal, Jayda L.; Spence, Dana M.; Martin, R. Scott

    2015-01-01

    In this paper, we describe the development of a planar, pillar array device that can be used to image either side of a tunable membrane, as well as sample and detect small molecules in a cell-free region of the microchip. The pores are created by sealing two parallel PDMS microchannels (a cell channel and a collector channel) over a gold pillar array (5 or 10 µm in height), with the device being characterized and optimized for small molecule cross-over while excluding a flowing cell line (here, red blood cells, RBCs). The device was characterized in terms of the flow rate dependence of cross-over of analyte and cell exclusion as well as the ability to perform amperometric detection of catechol and nitric oxide (NO) as they cross-over into the collector channel. Using catechol as the test analyte, the limits of detection (LOD) of the cross-over for the 10 µm and 5 µm pillar array heights were shown to be 50 nM and 106 nM, respectively. Detection of NO was made possible with a glassy carbon detection electrode (housed in the collector channel) modified with Pt-black and Nafion, to enhance sensitivity and selectivity, respectively. Reproducible cross-over of NO as a function of concentration resulted in a linear correlation (r2 = 0.995, 7.6 µM - 190 µM), with an LOD for NO of 230 nM on the glassy carbon-Pt-black-0.05% Nafion electrode. The applicability of the device was demonstrated by measuring the NO released from hypoxic RBCs, with the device allowing the released NO to cross-over into a cell free channel where it was detected in close to real-time. This type of device is an attractive alternative to the use of 3-dimensional devices with polycarbonate membranes, as either side of the membrane can be imaged and facile integration of electrochemical detection is possible. PMID:25105251

  5. Two-Point Stretchable Electrode Array for Endoluminal Electrochemical Impedance Spectroscopy Measurements of Lipid-Laden Atherosclerotic Plaques.

    PubMed

    Packard, René R Sevag; Zhang, XiaoXiao; Luo, Yuan; Ma, Teng; Jen, Nelson; Ma, Jianguo; Demer, Linda L; Zhou, Qifa; Sayre, James W; Li, Rongsong; Tai, Yu-Chong; Hsiai, Tzung K

    2016-09-01

    Four-point electrode systems are commonly used for electric impedance measurements of biomaterials and tissues. We introduce a 2-point system to reduce electrode polarization for heterogeneous measurements of vascular wall. Presence of endoluminal oxidized low density lipoprotein (oxLDL) and lipids alters the electrochemical impedance that can be measured by electrochemical impedance spectroscopy (EIS). We developed a catheter-based 2-point micro-electrode configuration for intravascular deployment in New Zealand White rabbits. An array of 2 flexible round electrodes, 240 µm in diameter and separated by 400 µm was microfabricated and mounted on an inflatable balloon catheter for EIS measurement of the oxLDL-rich lesions developed as a result of high-fat diet-induced hyperlipidemia. Upon balloon inflation, the 2-point electrode array conformed to the arterial wall to allow deep intraplaque penetration via alternating current (AC). The frequency sweep from 10 to 300 kHz generated an increase in capacitance, providing distinct changes in both impedance (Ω) and phase (ϕ) in relation to varying degrees of intraplaque lipid burden in the aorta. Aortic endoluminal EIS measurements were compared with epicardial fat tissue and validated by intravascular ultrasound and immunohistochemistry for plaque lipids and foam cells. Thus, we demonstrate a new approach to quantify endoluminal EIS via a 2-point stretchable electrode strategy. PMID:26857007

  6. Recording long-term potentiation of synaptic transmission by three-dimensional multi-electrode arrays

    PubMed Central

    Kopanitsa, Maksym V; Afinowi, Nurudeen O; Grant, Seth GN

    2006-01-01

    Background Multi-electrode arrays (MEAs) have become popular tools for recording spontaneous and evoked electrical activity of excitable tissues. The majority of previous studies of synaptic transmission in brain slices employed MEAs with planar electrodes that had limited ability to detect signals coming from deeper, healthier layers of the slice. To overcome this limitation, we used three-dimensional (3D) MEAs with tip-shaped electrodes to probe plasticity of field excitatory synaptic potentials (fEPSPs) in the CA1 area of hippocampal slices of 129S5/SvEvBrd and C57BL/6J-TyrC-Brd mice. Results Using 3D MEAs, we were able to record larger fEPSPs compared to signals measured by planar MEAs. Several stimulation protocols were used to induce long-term potentiation (LTP) of synaptic responses in the CA1 area recorded following excitation of Schäffer collateral/commissural fibres. Either two trains of high frequency tetanic stimulation or three trains of theta-burst stimulation caused a persistent, pathway specific enhancement of fEPSPs that remained significantly elevated for at least 60 min. A third LTP induction protocol that comprised 150 pulses delivered at 5 Hz, evoked moderate LTP if excitation strength was increased to 1.5× of the baseline stimulus. In all cases, we observed a clear spatial plasticity gradient with maximum LTP levels detected in proximal apical dendrites of pyramidal neurones. No significant differences in the manifestation of LTP were observed between 129S5/SvEvBrd and C57BL/6J-TyrC-Brd mice with the three protocols used. All forms of plasticity were sensitive to inhibition of N-methyl-D-aspartate (NMDA) receptors. Conclusion Principal features of LTP (magnitude, pathway specificity, NMDA receptor dependence) recorded in the hippocampal slices using MEAs were very similar to those seen in conventional glass electrode experiments. Advantages of using MEAs are the ability to record from different regions of the slice and the ease of conducting

  7. A new high-density (25 electrodes/mm2) penetrating microelectrode array for recording and stimulating sub-millimeter neuroanatomical structures

    NASA Astrophysics Data System (ADS)

    Wark, H. A. C.; Sharma, R.; Mathews, K. S.; Fernandez, E.; Yoo, J.; Christensen, B.; Tresco, P.; Rieth, L.; Solzbacher, F.; Normann, R. A.; Tathireddy, P.

    2013-08-01

    Objective. Among the currently available neural interface devices, there has been a need for a penetrating electrode array with a high electrode-count and high electrode-density (the number of electrodes/mm2) that can be used for electrophysiological studies of sub-millimeter neuroanatomical structures. We have developed such a penetrating microelectrode array with both a high electrode-density (25 electrodes/mm2) and high electrode-count (up to 96 electrodes) for small nervous system structures, based on the existing Utah Slanted Electrode Array (USEA). Such high electrode-density arrays are expected to provide greater access to nerve fibers than the conventionally spaced USEA especially in small diameter nerves. Approach. One concern for such high density microelectrode arrays is that they may cause a nerve crush-type injury upon implantation. We evaluated this possibility during acute (<10 h) in vivo experiments with electrode arrays implanted into small diameter peripheral nerves of anesthetized rats (sciatic nerve) and cats (pudendal nerve). Main results. Successful intrafascicular implantation and viable nerve function was demonstrated via microstimulation, single-unit recordings and histological analysis. Measurements of the electrode impedances and quantified electrode dimensions demonstrated fabrication quality. The results of these experiments show that such high density neural interfaces can be implanted acutely into neural tissue without causing a complete nerve crush injury, while mediating intrafascicular access to fibers in small diameter peripheral nerves. Significance. This new penetrating microelectrode array has characteristics un-matched by other neural interface devices currently available for peripheral nervous system neurophysiological research.

  8. Robust myoelectric signal detection based on stochastic resonance using multiple-surface-electrode array made of carbon nanotube composite paper

    NASA Astrophysics Data System (ADS)

    Shirata, Kento; Inden, Yuki; Kasai, Seiya; Oya, Takahide; Hagiwara, Yosuke; Kaeriyama, Shunichi; Nakamura, Hideyuki

    2016-04-01

    We investigated the robust detection of surface electromyogram (EMG) signals based on the stochastic resonance (SR) phenomenon, in which the response to weak signals is optimized by adding noise, combined with multiple surface electrodes. Flexible carbon nanotube composite paper (CNT-cp) was applied to the surface electrode, which showed good performance that is comparable to that of conventional Ag/AgCl electrodes. The SR-based EMG signal system integrating an 8-Schmitt-trigger network and the multiple-CNT-cp-electrode array successfully detected weak EMG signals even when the subject’s body is in the motion, which was difficult to achieve using the conventional technique. The feasibility of the SR-based EMG detection technique was confirmed by demonstrating its applicability to robot hand control.

  9. Unilocular radiolucencies of anterior mandible in young patients: A 10 year retrospective study

    PubMed Central

    Mohanty, Sujata; Gulati, Ujjwal; Mediratta, Akshat; Ghosh, Sujoy

    2013-01-01

    Introduction: Mandibular anterior region is an uncommon site for occurrence of intrabony pathologies. Unilocular presentation of a lesion is again less common than multilocular appearance. Demographically, most lesions occur in middle to elderly age group. The study is designed to review the pathologies manifesting a combination of these rare demographic and radiological criteria. Materials and Methods: A retrospective analysis of patients with anterior unilocular radiolucencies of mandible in young patients was done. Records of past 10 years were searched. There were a total of 17 patients. Their clinical history and radiographs were reviewed from the case files and correlated with histopathological examination of the lesion. Results: Nine different pathologies constituted the sample size of 17. A wide array of lesions was found to manifest similar signs and symptoms and radiographic findings namely ameloblastoma (three), adenomatoid odontogenic tumor (AOT, four), odontogenic keratocyst (OKC, three), ossifying fibroma (OF, two), idiopathic bone cavity (IBC, one), dentigerous cyst (DC, one), radicular cyst (RC, one), central giant cell granuloma (CGCG, one), and calcifying odontogenic cyst (COC, one). Conclusion: Anterior mandible is a rare site for occurrence of intrabony pathologies. Majority of patients are females. Lesions acquire large size before they are detected. Growth occurs more in length than in width. Root resorption is not uncommon and root displacement is almost a consistent feature. PMID:24163555

  10. Biaxially stretchable supercapacitors based on the buckled hybrid fiber electrode array

    NASA Astrophysics Data System (ADS)

    Zhang, Nan; Zhou, Weiya; Zhang, Qiang; Luan, Pingshan; Cai, Le; Yang, Feng; Zhang, Xiao; Fan, Qingxia; Zhou, Wenbin; Xiao, Zhuojian; Gu, Xiaogang; Chen, Huiliang; Li, Kewei; Xiao, Shiqi; Wang, Yanchun; Liu, Huaping; Xie, Sishen

    2015-07-01

    In order to meet the growing need for smart bionic devices and epidermal electronic systems, biaxial stretchability is essential for energy storage units. Based on porous single-walled carbon nanotube/poly(3,4-ethylenedioxythiophene) (SWCNT/PEDOT) hybrid fiber, we designed and fabricated a biaxially stretchable supercapacitor, which possesses a unique configuration of the parallel buckled hybrid fiber array. Owing to the reticulate SWCNT film and the improved fabrication technique, the hybrid fiber retained its porous architecture both outwardly and inwardly, manifesting a superior capacity of 215 F g-1. H3PO4-polyvinyl alcohol gel with an optimized component ratio was introduced as both binder and stretchable electrolyte, which contributed to the regularity and stability of the buckled fiber array. The buckled structure and the quasi one-dimensional character of the fibers endow the supercapacitor with 100% stretchability along all directions. In addition, the supercapacitor exhibited good transparency, as well as excellent electrochemical properties and stability after being stretched 5000 times.In order to meet the growing need for smart bionic devices and epidermal electronic systems, biaxial stretchability is essential for energy storage units. Based on porous single-walled carbon nanotube/poly(3,4-ethylenedioxythiophene) (SWCNT/PEDOT) hybrid fiber, we designed and fabricated a biaxially stretchable supercapacitor, which possesses a unique configuration of the parallel buckled hybrid fiber array. Owing to the reticulate SWCNT film and the improved fabrication technique, the hybrid fiber retained its porous architecture both outwardly and inwardly, manifesting a superior capacity of 215 F g-1. H3PO4-polyvinyl alcohol gel with an optimized component ratio was introduced as both binder and stretchable electrolyte, which contributed to the regularity and stability of the buckled fiber array. The buckled structure and the quasi one-dimensional character of the

  11. A new multi-electrode array design for chronic neural recording, with independent and automatic hydraulic positioning.

    PubMed

    Sato, T; Suzuki, T; Mabuchi, K

    2007-02-15

    We report on a new microdrive design, which enables the construction of multi-electrode arrays capable of chronically recording the multi-unit neural activity of waking animals. Our principal motivation for inventing this device was to simplify the task of positioning electrodes, which consumes a considerable amount of time and requires a high level of skill. With the new microdrives, each electrode is independently and automatically driven into place. A hydraulic drive system is adopted to reduce the size, weight, and cost of the structure. The hydraulic fluid is also used as a part of the electrical circuit, and facilitates the wiring of the electrodes. A routing system has been attached to reduce the number of tube connections. The microdrive is cylindrical, has a diameter of 23.5 mm, a height of 37 mm, and a weight of 15 g. It allows for up to 22 electrodes, which are arranged on a 0.35 mm grid. Each electrode can be positioned at any depth up to approximately 4mm. The microdrive was evaluated under acute and chronic recording experiments, and is shown to be capable of automatically positioning each electrode and successfully recording the neural signals of waking rats. PMID:16996616

  12. Barbed channels enhance unidirectional connectivity between neuronal networks cultured on multi electrode arrays

    PubMed Central

    le Feber, Joost; Postma, Wybren; de Weerd, Eddy; Weusthof, Marcel; Rutten, Wim L. C.

    2015-01-01

    Cultured neurons on multi electrode arrays (MEAs) have been widely used to study various aspects of neuronal (network) functioning. A possible drawback of this approach is the lack of structure in these networks. At the single cell level, several solutions have been proposed to enable directed connectivity, and promising results were obtained. At the level of connected sub-populations, a few attempts have been made with promising results. First assessment of the designs' functionality, however, suggested room for further improvement. We designed a two chamber MEA aiming to create a unidirectional connection between the networks in both chambers (“emitting” and “receiving”). To achieve this unidirectionality, all interconnecting channels contained barbs that hindered axon growth in the opposite direction (from receiving to emitting chamber). Visual inspection showed that axons predominantly grew through the channels in the promoted direction. This observation was confirmed by spontaneous activity recordings. Cross-correlation between the signals from two electrodes inside the channels suggested signal propagation at ≈2 m/s from emitting to receiving chamber. Cross-correlation between the firing patterns in both chambers indicated that most correlated activity was initiated in the emitting chamber, which was also reflected by a significantly lower fraction of partial bursts (i.e., a one-chamber-only burst) in the emitting chamber. Finally, electrical stimulation in the emitting chamber induced a fast response in that chamber, and a slower response in the receiving chamber. Stimulation in the receiving chamber evoked a fast response in that chamber, but no response in the emitting chamber. These results confirm the predominantly unidirectional nature of the connecting channels from emitting to receiving chamber. PMID:26578869

  13. Fabrication of nano-electrode arrays of free-standing carbon nanotubes on nano-patterned substrate by imprint method

    NASA Astrophysics Data System (ADS)

    Chang, W. S.; Kim, J. W.; Choi, D. G.; Han, C. S.

    2011-01-01

    The synthesis of isolated carbon nanotubes with uniform outer diameters and ordered spacing over wafer-scale areas was investigated for fabrication of nano-electrode arrays on silicon wafers for field emission and sensor devices. Multi-walled carbon nanotubes (MWCNTs) were grown on TiN electrode layer with iron catalyst patterned by nano-imprint lithography (NIL), which allows the precise placement of individual CNTs on a substrate. The proposed techniques, including plasma-enhanced chemical vapor deposition (PECVD) and NIL, are simple, inexpensive, and reproducible methods for fabrication of nano-scale devices in large areas. The catalyst patterns were defined by an array of circles with 200 nm in diameter, and variable lengths of pitch. The nano-patterned master and Fe catalyst were observed with good pattern fidelity over a large area by atomic force microscope (AFM) and scanning electron microscopy (SEM). Nano-electrodes of MWCNTs had diameters ranging from 50 nm to 100 nm and lengths of about 300 nm. Field emission tests showed the reducing ignition voltage as the geometry of nanotube arrays was controlled by catalyst patterning. These results showed a wafer-scale approach to the control of the size, pitch, and position of nano-electrodes of nanotubes for various applications including electron field-emission sources, electrochemical probes, functionalized sensor elements, and so on.

  14. Investigation of the electroactive capability for the supercapacitor electrode with cobalt oxide rhombus nanopillar and nanobrush arrays

    NASA Astrophysics Data System (ADS)

    Liu, Yu-Bin; Lin, Lu-Yin; Huang, Ying-Yu; Tu, Chao-Chi

    2016-05-01

    Well-defined nanostructures of the cobalt oxide are designed intensively to pursue large surface area and high conductivity as the electroactive material for supercapacitors (SCs). Instead of merely fabricating effective electroactive materials, two kinds of the cobalt oxide nanostructures synthesized directly on nickel foam to achieve good contact between the material and the substrate are compared to clarify the growth mechanism and the structure-dependent SC performance. The nanobrushes are completely composed of nanoparticles while the rhombus nanopillars present integrated structure by the recrystallization of single nanopillars. A higher specific capacitance (CF) of 509 F/g is obtained for the SC electrode with CoO rhombus nanopillar array at a scan rate of 10 mV/s, comparing to that of 169 F/g for the CoO nanobrush array-based SC electrode, due to the larger electroactive surface area and less recombination sites for the former case. The CF value is enhanced by 38% as compared with the initial value after 3000 cycles of repeated charge/discharge process for the CoO rhombus nanopillar array-based SC electrode due to the activation of the material. The results provide a blue print for achieving highly efficient SC electrode by carefully designing the well-established electroactive material to attain facile and long-lasting faradic reactions.

  15. Combining Multiple Electrode Arrays for Two-Dimensional Electrical Resistivity Imaging Using the Unsupervised Classification Technique

    NASA Astrophysics Data System (ADS)

    Ishola, K. S.; Nawawi, M. N. M.; Abdullah, K.

    2015-06-01

    This article describes the use of k-means clustering, an unsupervised image classification technique, to help interpret subsurface targets. The k-means algorithm is employed to combine and classify the two-dimensional (2D) inverse resistivity models obtained from three different electrode arrays. The algorithm is initialized through the selection of the number of clusters, number of iterations and other parameters such as stopping criteria. Automatically, it seeks to find groups of closely related resistivity values that belong to the same cluster and are more similar to each other than resistivity values belonging to other clusters. The approach is applied to both synthetic and field data. The 2D postinversions of the resistivity data were preprocessed by resampling and interpolating to the same coordinate. Following the preprocessing, the three images are combined into a single classified image. All the image preprocessing, manipulation and analysis are performed using the PCI Geomatics software package. The results of the clustering and classification are presented as classified images. An assessment of the performance of the individual and combined images for the synthetic models is carried out using an error matrix, mean absolute error and mean absolute percent error. The estimated errors show that images obtained from maximum values of the reconstructed resistivity for the different models give the best representation of the true models. Additionally, the overall accuracy and kappa values show good agreement between the combined classified images and true models. Depending on the model, the overall accuracy ranges from 86 to 99 %, while the kappa coefficient is in the range of 54-98 %. Classified images with kappa coefficients greater than 0.8 show strong agreement, while images with kappa coefficients greater than 0.5 but less than 0.8 give moderate agreement. For the field data, the k-mean classifier produces images that incorporate structural features of

  16. Opto- μECoG array: a hybrid neural interface with transparent μECoG electrode array and integrated LEDs for optogenetics.

    PubMed

    Kwon, Ki Yong; Sirowatka, Brenton; Weber, Arthur; Li, Wen

    2013-10-01

    Electrocorticogram (ECoG) recordings, taken from electrodes placed on the surface of the cortex, have been successfully implemented for control of brain machine interfaces (BMIs). Optogenetics, direct optical stimulation of neurons in brain tissue genetically modified to express channelrhodopsin-2 (ChR2), enables targeting of specific types of neurons with sub-millisecond temporal precision. In this work, we developed a BMI device, called an Opto- μECoG array, which combines ECoG recording and optogenetics-based stimulation to enable multichannel, bi-directional interactions with neurons. The Opto- μECoG array comprises two sub-arrays, each containing a 4 × 4 distribution of micro-epidural transparent electrodes ( ∼ 200 μm diameter) and embedded light-emitting diodes (LEDs) for optical neural stimulation on a 2.5 × 2.5 mm² footprint to match the bilateral hemispherical area of the visual cortex in a rat. The transparent electrodes were fabricated with indium tin oxide (ITO). Parylene-C served as the main structural and packaging material for flexibility and biocompatibility. Optical, electrical, and thermal characteristics of the fabricated device were investigated and in vivo experiments were performed to evaluate the efficacy of the device. PMID:24144668

  17. Spontaneous complete resolution of a radiolucent shadow associated with an impacted mandibular third molar.

    PubMed

    Naqvi, Ambareen; Steel, Clare; Koshal, Sonita

    2016-02-01

    Impacted third molars are commonly associated with areas of radiolucency, and treatment can damage the adjacent structures, specifically the inferior alveolar nerve. We report a rare and interesting case of a large radiolucent area associated with an impacted mandibular wisdom tooth that resolved over 7 years with no intervention. We postulate that the unexpected movement of the tooth over this time caused spontaneous resolution of the cystic space, a natural decompression, which highlights the option of monitoring. PMID:26657717

  18. Method of interpreting impedance distribution of an earth formation obtained by a moving array using end emitting current electrodes sequentially activated and a series of potential electrodes

    SciTech Connect

    Chapman, C.W.; Angehrn, J.A.

    1987-06-30

    Method of synthesizing the true response characteristics of a combination of different hole-centered electric logging tools in a variety of difficult borehole conditions as provided by (1) determining impedance values of an earth formation penetrated by a borehole filled with a drilling mud of resistivity (Rm), and (2) selectively manipulating the impedance values as impedance entries of a matrix so as to synthesize operations of different hole-centered tools over an associated depth increment with surprising accuracy. Each of the impedance matrices is associated with a matrix gather indexed to one of series of finite, overlapping depth scan increments of the formation measured along the borehole. Each scan increment is dependent on the array length L of the electrode array to define shallow and deep depth markers as well as being centrally indexed to the depth in the borehole of a mid-central electrode assembly of the array at the time of data collection. This provides a true indication of the formation resistivity (Rt) even though the formation is interspaced from the borehole by an invaded zone of resistivity (Rxo) of unknown lateral extend due to drilling mud filtrate invasion.

  19. THE 4-AMINOPYRIDINE IN VITRO EPILEPSY MODEL ANALYZED WITH A PERFORATED MULTI-ELECTRODE ARRAY

    PubMed Central

    Gonzalez-Sulser, Alfredo; Wang, Jing; Motamedi, Gholam K.; Avoli, Massimo; Vicini, Stefano; Dzakpasu, Rhonda

    2010-01-01

    Epileptiform discharges recorded in the 4-aminopyridine (4-AP) in vitro epilepsy model are mediated by glutamatergic and GABAergic signaling. Using a 60-channel perforated multi-electrode array (pMEA) on corticohippocampal slices from 2 to 3 week old mice we recorded interictal- and ictal-like events. When glutamatergic transmission was blocked, interictal-like events events no longer initiated in the hilus or CA3/CA1 pyramidal layers but originated from the dentate gyrus granule and molecular layers. Furthermore, frequencies of interictal-like events were reduced and durations were increased in these regions while cortical discharges were completely blocked. Following GABAA receptor blockade interictal-like events no longer propagated to the dentate gyrus while their frequency in CA3 increased; in addition, ictal-like cortical events became shorter while increasing in frequency. Lastly, drugs that affect tonic and synaptic GABAergic conductance modulate the frequency, duration, initiation and propagation of interictal-like events. These findings confirm and expand on previous studies indicating that multiple synaptic mechanisms contribute to synchronize neuronal network activity in forebrain structures. PMID:20955719

  20. Evaluation of micro Electroretinograms Recorded with Multiple Electrode Array to Assess Focal Retinal Function

    PubMed Central

    Fujii, Momo; Sunagawa, Genshiro A.; Kondo, Mineo; Takahashi, Masayo; Mandai, Michiko

    2016-01-01

    Full-field electroretinograms (ERGs) are used to objectively assess the mass function of the retina, whereas focal ERGs are used to evaluate the focal retinal function. The purpose of this study was to determine the usefulness of a multiple electrode array (MEA) system for recording ex vivo micro ERGs (mERGs) together with multiunit spike responses of the retinal ganglion cells (RGCs) to assess focal retinal function in isolated mouse retinas. The a- and b-waves of the full-field ERGs were present in the mERG. The b-wave was blocked by L-AP4, an inhibitor of the mGluR6 receptor, and the OFF-component was blocked by exposure to PDA, an antagonist of ionotropic glutamate receptors, with a corresponding RGC responses. mERGs were also recorded from mice with progressive retinal degeneration, the C57BL/6J-Pde6brd1-2J/J (rd1) mice, from which conventional full-field ERGs are non-recordable. A blockade of the glutamate receptors indicated that the negative wave of rd1 mice do not originate from the photoreceptors but from the second or third order neurons. This technique of recording mERGs will be useful in assessing the focal properties of the retinas obtained from eyes with pathology and also to follow the recovery of the physiology of the retina in regenerative studies. PMID:27480484

  1. An integrated multi-electrode-optrode array for in vitro optogenetics

    PubMed Central

    Welkenhuysen, Marleen; Hoffman, Luis; Luo, Zhengxiang; De Proft, Anabel; Van den Haute, Chris; Baekelandt, Veerle; Debyser, Zeger; Gielen, Georges; Puers, Robert; Braeken, Dries

    2016-01-01

    Modulation of a group of cells or tissue needs to be very precise in order to exercise effective control over the cell population under investigation. Optogenetic tools have already demonstrated to be of great value in the study of neuronal circuits and in neuromodulation. Ideally, they should permit very accurate resolution, preferably down to the single cell level. Further, to address a spatially distributed sample, independently addressable multiple optical outputs should be present. In current techniques, at least one of these requirements is not fulfilled. In addition to this, it is interesting to directly monitor feedback of the modulation by electrical registration of the activity of the stimulated cells. Here, we present the fabrication and characterization of a fully integrated silicon-based multi-electrode-optrode array (MEOA) for in vitro optogenetics. We demonstrate that this device allows for artifact-free electrical recording. Moreover, the MEOA was used to reliably elicit spiking activity from ChR2-transduced neurons. Thanks to the single cell resolution stimulation capability, we could determine spatial and temporal activation patterns and spike latencies of the neuronal network. This integrated approach to multi-site combined optical stimulation and electrical recording significantly advances today’s tool set for neuroscientists in their search to unravel neuronal network dynamics. PMID:26832455

  2. All-carbon multi-electrode array for real-time in vitro measurements of oxidizable neurotransmitters.

    PubMed

    Picollo, Federico; Battiato, Alfio; Bernardi, Ettore; Plaitano, Marilena; Franchino, Claudio; Gosso, Sara; Pasquarelli, Alberto; Carbone, Emilio; Olivero, Paolo; Carabelli, Valentina

    2016-01-01

    We report on the ion beam fabrication of all-carbon multi electrode arrays (MEAs) based on 16 graphitic micro-channels embedded in single-crystal diamond (SCD) substrates. The fabricated SCD-MEAs are systematically employed for the in vitro simultaneous amperometric detection of the secretory activity from populations of chromaffin cells, demonstrating a new sensing approach with respect to standard techniques. The biochemical stability and biocompatibility of the SCD-based device combined with the parallel recording of multi-electrodes array allow: i) a significant time saving in data collection during drug screening and/or pharmacological tests over a large number of cells, ii) the possibility of comparing altered cell functionality among cell populations, and iii) the repeatition of acquisition runs over many cycles with a fully non-toxic and chemically robust bio-sensitive substrate. PMID:26857940

  3. All-carbon multi-electrode array for real-time in vitro measurements of oxidizable neurotransmitters

    PubMed Central

    Picollo, Federico; Battiato, Alfio; Bernardi, Ettore; Plaitano, Marilena; Franchino, Claudio; Gosso, Sara; Pasquarelli, Alberto; Carbone, Emilio; Olivero, Paolo; Carabelli, Valentina

    2016-01-01

    We report on the ion beam fabrication of all-carbon multi electrode arrays (MEAs) based on 16 graphitic micro-channels embedded in single-crystal diamond (SCD) substrates. The fabricated SCD-MEAs are systematically employed for the in vitro simultaneous amperometric detection of the secretory activity from populations of chromaffin cells, demonstrating a new sensing approach with respect to standard techniques. The biochemical stability and biocompatibility of the SCD-based device combined with the parallel recording of multi-electrodes array allow: i) a significant time saving in data collection during drug screening and/or pharmacological tests over a large number of cells, ii) the possibility of comparing altered cell functionality among cell populations, and iii) the repeatition of acquisition runs over many cycles with a fully non-toxic and chemically robust bio-sensitive substrate. PMID:26857940

  4. Numerically controlled atmospheric-pressure plasma sacrificial oxidation using electrode arrays for improving silicon-on-insulator layer uniformity

    NASA Astrophysics Data System (ADS)

    Takei, Hiroyasu; Yoshinaga, Keinosuke; Matsuyama, Satoshi; Yamauchi, Kazuto; Sano, Yasuhisa

    2015-01-01

    Silicon-on-insulator (SOI) wafers are important semiconductor substrates in high-performance devices. In accordance with device miniaturization requirements, ultrathin and highly uniform top silicon layers (SOI layers) are required. A novel method involving numerically controlled (NC) atmospheric-pressure plasma sacrificial oxidation using an electrode array system was developed for the effective fabrication of an ultrathin SOI layer with extremely high uniformity. Spatial resolution and oxidation properties are the key factors controlling ultraprecision machining. The controllability of plasma oxidation and the oxidation properties of the resulting experimental electrode array system were examined. The results demonstrated that the method improved the thickness uniformity of the SOI layer over one-sixth of the area of an 8-in. wafer area.

  5. All-carbon multi-electrode array for real-time in vitro measurements of oxidizable neurotransmitters

    NASA Astrophysics Data System (ADS)

    Picollo, Federico; Battiato, Alfio; Bernardi, Ettore; Plaitano, Marilena; Franchino, Claudio; Gosso, Sara; Pasquarelli, Alberto; Carbone, Emilio; Olivero, Paolo; Carabelli, Valentina

    2016-02-01

    We report on the ion beam fabrication of all-carbon multi electrode arrays (MEAs) based on 16 graphitic micro-channels embedded in single-crystal diamond (SCD) substrates. The fabricated SCD-MEAs are systematically employed for the in vitro simultaneous amperometric detection of the secretory activity from populations of chromaffin cells, demonstrating a new sensing approach with respect to standard techniques. The biochemical stability and biocompatibility of the SCD-based device combined with the parallel recording of multi-electrodes array allow: i) a significant time saving in data collection during drug screening and/or pharmacological tests over a large number of cells, ii) the possibility of comparing altered cell functionality among cell populations, and iii) the repeatition of acquisition runs over many cycles with a fully non-toxic and chemically robust bio-sensitive substrate.

  6. Collection, focusing, and metering of DNA in microchannels using addressable electrode arrays for portable low-power bioanalysis

    PubMed Central

    Shaikh, Faisal A.; Ugaz, Victor M.

    2006-01-01

    Although advances in microfluidic technology have enabled increasingly sophisticated biosensing and bioassay operations to be performed at the microscale, many of these applications employ such small amounts of charged biomolecules (DNA, proteins, and peptides) that they must first be preconcentrated to a detectable level. Efficient strategies for precisely handling minute quantities of biomolecules in microchannel geometries are critically needed; however, it has proven challenging to achieve simultaneous concentration, focusing, and metering capabilities with current-generation sample-injection technology. By using microfluidic chips incorporating arrays of individually addressable microfabricated electrodes, we demonstrate that DNA can be sequentially concentrated, focused into a narrow zone, metered, and injected into an analysis channel. This technique transports charged biomolecules between active electrodes upon application of a small potential difference (1 V) and is capable of achieving orders of magnitude concentration increases within a small device footprint. The collected samples are highly focused, with sample zone size and shape defined solely by electrode geometry. PMID:16551750

  7. Electrogenerated Chemiluminescence of BODIPY, Ru(bpy)32+, and 9,10-Diphenylanthracene Using Interdigitated Array Electrodes

    SciTech Connect

    Nepomnyashchii, Alexander B.; Kolesov, Grigory; Parkinson, Bruce A.

    2013-07-10

    Interdigitated array electrodes (IDAs) were used to produce steady-state electrogenerated chemiluminescence (ECL) by annihilation of oxidized and reduced forms of a substituted boron dipyrromethene (BODIPY) dye, 9,10-diphenylanthracene (DPA), and ruthenium(II) tris(bypiridine) (Ru-(bpy)32+). Digital simulations were in good agreement with the experimentally obtained currents and light outputs. Coreactant experiments, using tri-n-propylamine and benzoyl peroxide as a sacrificial homogeneous reductant or oxidant, show currents corresponding to electrode reactions of the dyes and not the oxidation or reduction of the coreactants. The results show that interdigitated arrays can produce stable ECL where the light intensity is magnified due to the larger currents as a consequence of feedback between generator and collector electrodes in the IDA. The light output for ECL is around 100 times higher than that obtained with regular planar electrodes with similar area. This material is based upon work supported as part of the Center of Molecular Electrocatalysis, an Energy Frontier Research Center funded by the U.S. Department of Energy, Office of Science, Office of Basic Energy Sciences.

  8. Determination of salbutamol in human plasma and urine by high-performance liquid chromatography with a coulometric electrode array system.

    PubMed

    Zhang, X Z; Gan, Y R; Zhao, F N

    2004-01-01

    A method is developed to determine salbutamol in human plasma and urine using high-performance liquid chromatography (HPLC) with a coulometric electrode array system, based on the electrochemical behavior of salbutamol at graphite electrode. The mobile phase component A is 30 mM sodium dihydroxy phosphate-30 mM triethylamine and is adjusted to pH 6.0 with 20% phosphate acid. The mobile phase component B is methanol. The optimized mobile phase composition was A and B in the proportion of 90:10 (v/v). Paracetamol is selected as the external standard. The human plasma and urine samples are pretreated using solid-phase extraction cartridges (Sep-Pak Silica), and the eluting solution is monitored by the coulometric electrode array system. The electrode potentials are set at 300, 400, 550, and 650 mV, respectively. Calibration curves show good linearity, and the recovery of salbutamol proves to be constant and unaffected by the concentration of the drug. This method, developed using HPLC-electrochemical detection, is reproducible and sensitive enough for the determination of salbutamol in human plasma and urine. PMID:15189600

  9. Electropolymerization of Uniform Polyaniline Nanorod Arrays on Conducting Oxides as Counter Electrodes in Dye-Sensitized Solar Cells.

    PubMed

    He, Ziming; Liu, Jing; Khoo, Si Yun; Tan, Timothy Thatt Yang

    2016-01-01

    Conventional techniques for the synthesis of oriented polyaniline (PANI) nanostructures are often complex or time consuming. Through an innovative reduced graphene oxide (rGO) modified FTO and a low-potential electropolymerization strategy, the rapid and template-free growth of a highly ordered PANI nanorod array on the FTO substrate is realized. The highly ordered nanostructure of the PANI array leads to a high electrocatalytic activity and chemical stability. The importance of the polymerization potential and rGO surface modification to achieve this nanostructure is revealed. Compared to platinum, the PANI nanorod array exhibits an enhanced performance and stability as counter electrodes in dye-sensitized solar cells, with a 17.6 % enhancement in power conversion efficiency. PMID:26732134

  10. Radiolucent rim as a possible diagnostic aid for differentiating jaw lesions.

    PubMed

    Mortazavi, Hamed; Baharvand, Maryam; Rahmani, Somayeh; Jafari, Soudeh; Parvaei, Parvin

    2015-12-01

    In this study, we formulate a new proposal that complements previous classifications in order to assist dental practitioners in performing a differential diagnosis based on patients' radiographs. We used general search engines and specialized databases such as Google Scholar, PubMed, PubMed Central, MedLine Plus, Science Direct, Scopus, and well-recognized textbooks to find relevant studies by using keywords such as "jaw disease," "jaw lesions," "radiolucent rim," "radiolucent border," and "radiolucent halo." More than 200 articles were found, of which 70 were broadly relevant to the topic. We ultimately included 50 articles that were closely related to the topic of interest. When the relevant data were compiled, the following eight lesions were identified as having a radiolucent rim: periapical cemento-osseous dysplasia, focal cemento-osseous dysplasia, florid cemento-osseous dysplasia, cemento-ossifying fibroma, osteoid osteoma, osteoblastoma, odontoma, and cementoblastoma. We propose a novel subcategory, jaw lesions with a radiolucent rim, which includes eight entities. The implementation of this new category can help improve the diagnoses that dental practitioners make based on patients' radiographs. PMID:26730374

  11. Radiolucent rim as a possible diagnostic aid for differentiating jaw lesions

    PubMed Central

    Mortazavi, Hamed; Rahmani, Somayeh; Jafari, Soudeh; Parvaei, Parvin

    2015-01-01

    In this study, we formulate a new proposal that complements previous classifications in order to assist dental practitioners in performing a differential diagnosis based on patients' radiographs. We used general search engines and specialized databases such as Google Scholar, PubMed, PubMed Central, MedLine Plus, Science Direct, Scopus, and well-recognized textbooks to find relevant studies by using keywords such as "jaw disease," "jaw lesions," "radiolucent rim," "radiolucent border," and "radiolucent halo." More than 200 articles were found, of which 70 were broadly relevant to the topic. We ultimately included 50 articles that were closely related to the topic of interest. When the relevant data were compiled, the following eight lesions were identified as having a radiolucent rim: periapical cemento-osseous dysplasia, focal cemento-osseous dysplasia, florid cemento-osseous dysplasia, cemento-ossifying fibroma, osteoid osteoma, osteoblastoma, odontoma, and cementoblastoma. We propose a novel subcategory, jaw lesions with a radiolucent rim, which includes eight entities. The implementation of this new category can help improve the diagnoses that dental practitioners make based on patients' radiographs. PMID:26730374

  12. Photoelectrochemical Activity of As-Grown, a-Fe2O3 Nanowire Array Electrodes for Water Splitting

    SciTech Connect

    Chernomordik, B. D.; Russell, H. B.; Cvelbar, U.; Jasinski, J. B.; Kumar, V.; Deutsch, T.; Sunkara, M. K.

    2012-05-17

    Undoped hematite nanowire arrays grown using plasma oxidation of iron foils show significant photoactivity ({approx}0.38 mA cm{sup -2} at 1.5 V versus reversible hydrogen electrode in 1 M KOH). In contrast, thermally oxidized nanowire arrays grown on iron exhibit no photoactivity due to the formation of a thick (>7 {micro}m Fe{sub 1-x}O) interfacial layer. An atmospheric plasma oxidation process required only a few minutes to synthesize hematite nanowire arrays with a 1-5 {micro}m interfacial layer of magnetite between the nanowire arrays and the iron substrate. An amorphous oxide surface layer on hematite nanowires, if present, is shown to decrease the resulting photoactivity of as-synthesized, plasma grown nanowire arrays. The photocurrent onset potential is improved after removing the amorphous surface on the nanowires using an acid etch. A two-step method involving high temperature nucleation followed by growth at low temperature is shown to produce a highly dense and uniform coverage of nanowire arrays.

  13. Metal-organic framework derived hybrid Co3O4-carbon porous nanowire arrays as reversible oxygen evolution electrodes.

    PubMed

    Ma, Tian Yi; Dai, Sheng; Jaroniec, Mietek; Qiao, Shi Zhang

    2014-10-01

    Hybrid porous nanowire arrays composed of strongly interacting Co3O4 and carbon were prepared by a facile carbonization of the metal-organic framework grown on Cu foil. The resulting material, possessing a high surface area of 251 m(2) g(-1) and a large carbon content of 52.1 wt %, can be directly used as the working electrode for oxygen evolution reaction without employing extra substrates or binders. This novel oxygen evolution electrode can smoothly operate in alkaline solutions (e.g., 0.1 and 1.0 M KOH), affording a low onset potential of 1.47 V (vs reversible hydrogen electrode) and a stable current density of 10.0 mA cm(-2) at 1.52 V in 0.1 M KOH solution for at least 30 h, associated with a high Faradaic efficiency of 99.3%. The achieved ultrahigh oxygen evolution activity and strong durability, with superior performance in comparison to the state-of-the-art noble-metal/transition-metal and nonmetal catalysts, originate from the unique nanowire array electrode configuration and in situ carbon incorporation, which lead to the large active surface area, enhanced mass/charge transport capability, easy release of oxygen gas bubbles, and strong structural stability. Furthermore, the hybrid Co3O4-carbon porous nanowire arrays can also efficiently catalyze oxygen reduction reaction, featuring a desirable four-electron pathway for reversible oxygen evolution and reduction, which is potentially useful for rechargeable metal-air batteries, regenerative fuel cells, and other important clean energy devices. PMID:25216300

  14. Supported noble metals on hydrogen-treated TiO2 nanotube arrays as highly ordered electrodes for fuel cells.

    PubMed

    Zhang, Changkun; Yu, Hongmei; Li, Yongkun; Gao, Yuan; Zhao, Yun; Song, Wei; Shao, Zhigang; Yi, Baolian

    2013-04-01

    Hydrogen-treated TiO2 nanotube (H-TNT) arrays serve as highly ordered nanostructured electrode supports, which are able to significantly improve the electrochemical performance and durability of fuel cells. The electrical conductivity of H-TNTs increases by approximately one order of magnitude in comparison to air-treated TNTs. The increase in the number of oxygen vacancies and hydroxyl groups on the H-TNTs help to anchor a greater number of Pt atoms during Pt electrodeposition. The H-TNTs are pretreated by using a successive ion adsorption and reaction (SIAR) method that enhances the loading and dispersion of Pt catalysts when electrodeposited. In the SIAR method a Pd activator can be used to provide uniform nucleation sites for Pt and leads to increased Pt loading on the H-TNTs. Furthermore, fabricated Pt nanoparticles with a diameter of 3.4 nm are located uniformly around the pretreated H-TNT support. The as-prepared and highly ordered electrodes exhibit excellent stability during accelerated durability tests, particularly for the H-TNT-loaded Pt catalysts that have been annealed in ultrahigh purity H2 for a second time. There is minimal decrease in the electrochemical surface area of the as-prepared electrode after 1000 cycles compared to a 68 % decrease for the commercial JM 20 % Pt/C electrode after 800 cycles. X-ray photoelectron spectroscopy shows that after the H-TNT-loaded Pt catalysts are annealed in H2 for the second time, the strong metal-support interaction between the H-TNTs and the Pt catalysts enhances the electrochemical stability of the electrodes. Fuel-cell testing shows that the power density reaches a maximum of 500 mWcm(-2) when this highly ordered electrode is used as the anode. When used as the cathode in a fuel cell with extra-low Pt loading, the new electrode generates a specific power density of 2.68 kWg(Pt) (-1) . It is indicated that H-TNT arrays, which have highly ordered nanostructures, could be used as ordered electrode supports

  15. Analytical and numerical solutions of the potential and electric field generated by different electrode arrays in a tumor tissue under electrotherapy

    PubMed Central

    2011-01-01

    Background Electrotherapy is a relatively well established and efficient method of tumor treatment. In this paper we focus on analytical and numerical calculations of the potential and electric field distributions inside a tumor tissue in a two-dimensional model (2D-model) generated by means of electrode arrays with shapes of different conic sections (ellipse, parabola and hyperbola). Methods Analytical calculations of the potential and electric field distributions based on 2D-models for different electrode arrays are performed by solving the Laplace equation, meanwhile the numerical solution is solved by means of finite element method in two dimensions. Results Both analytical and numerical solutions reveal significant differences between the electric field distributions generated by electrode arrays with shapes of circle and different conic sections (elliptic, parabolic and hyperbolic). Electrode arrays with circular, elliptical and hyperbolic shapes have the advantage of concentrating the electric field lines in the tumor. Conclusion The mathematical approach presented in this study provides a useful tool for the design of electrode arrays with different shapes of conic sections by means of the use of the unifying principle. At the same time, we verify the good correspondence between the analytical and numerical solutions for the potential and electric field distributions generated by the electrode array with different conic sections. PMID:21943385

  16. Cementless Oxford unicompartmental knee replacement shows reduced radiolucency at one year.

    PubMed

    Pandit, H; Jenkins, C; Beard, D J; Gallagher, J; Price, A J; Dodd, C A F; Goodfellow, J W; Murray, D W

    2009-02-01

    We randomised 62 knees to receive either cemented or cementless versions of the Oxford unicompartmental knee replacement. The implants used in both arms of the study were similar, except that the cementless components were coated with porous titanium and hydroxyapatite. The tibial interfaces were studied with fluoroscopically-aligned radiographs. At one year there was no difference in clinical outcome between the two groups. Narrow radiolucent lines were seen at the bone-implant interfaces in 75% of cemented tibial components. These were partial in 43%, and complete in 32%. In the cementless implants, partial radiolucencies were seen in 7% and complete radiolucencies in none. These differences are statistically significant (p < 0.0001) and imply satisfactory bone ingrowth into the cementless implants. PMID:19190051

  17. An array of highly flexible electrodes with a tailored configuration locked by gelatin during implantation—initial evaluation in cortex cerebri of awake rats

    PubMed Central

    Agorelius, Johan; Tsanakalis, Fotios; Friberg, Annika; Thorbergsson, Palmi T.; Pettersson, Lina M. E.; Schouenborg, Jens

    2015-01-01

    Background: A major challenge in the field of neural interfaces is to overcome the problem of poor stability of neuronal recordings, which impedes long-term studies of individual neurons in the brain. Conceivably, unstable recordings reflect relative movements between electrode and tissue. To address this challenge, we have developed a new ultra-flexible electrode array and evaluated its performance in awake non-restrained animals. Methods:An array of eight separated gold leads (4 × 10 μm), individually flexible in 3D, were cut from a gold sheet using laser milling and insulated with Parylene C. To provide structural support during implantation into rat cortex, the electrode array was embedded in a hard gelatin based material, which dissolves after implantation. Recordings were made during 3 weeks. At termination, the animals were perfused with fixative and frozen to prevent dislocation of the implanted electrodes. A thick slice of brain tissue, with the electrode array still in situ, was made transparent using methyl salicylate to evaluate the conformation of the implanted electrode array. Results: Median noise levels and signal/noise remained relatively stable during the 3 week observation period; 4.3–5.9 μV and 2.8–4.2, respectively. The spike amplitudes were often quite stable within recording sessions and for 15% of recordings where single-units were identified, the highest-SNR unit had an amplitude higher than 150 μV. In addition, high correlations (>0.96) between unit waveforms recorded at different time points were obtained for 58% of the electrode sites. The structure of the electrode array was well preserved 3 weeks after implantation. Conclusions: A new implantable multichannel neural interface, comprising electrodes individually flexible in 3D that retain its architecture and functionality after implantation has been developed. Since the new neural interface design is adaptable, it offers a versatile tool to explore the function of various brain

  18. Re-evaluation of EMG-torque relation in chronic stroke using linear electrode array EMG recordings.

    PubMed

    Bhadane, Minal; Liu, Jie; Rymer, W Zev; Zhou, Ping; Li, Sheng

    2016-01-01

    The objective was to re-evaluate the controversial reports of EMG-torque relation between impaired and non-impaired sides using linear electrode array EMG recordings. Ten subjects with chronic stroke performed a series of submaximal isometric elbow flexion tasks. A 20-channel linear array was used to record surface EMG of the biceps brachii muscles from both impaired and non-impaired sides. M-wave recordings for bilateral biceps brachii muscles were also made. Distribution of the slope of the EMG-torque relations for the individual channels showed a quasi-symmetrical "M" shaped pattern. The lowest value corresponded to the innervation zone (IZ) location. The highest value from the slope curve for each side was selected for comparison to minimize the effect of electrode placement and IZ asymmetry. The slope was greater on the impaired side in 4 of 10 subjects. There were a weak correlation between slope ratio and strength ratio and a moderate to high correlation between slope ratio and M-wave ratio between two sides. These findings suggest that the EMG-torque relations are likely mediated and influenced by multiple factors. Our findings emphasize the importance of electrode placement and suggest the primary role of peripheral adaptive changes in the EMG-torque relations in chronic stroke. PMID:27349938

  19. Signal Amplification in a Microchannel from Redox Cycling with Varied Electroactive Configurations of an Individually-Addressable Microband Electrode Array

    PubMed Central

    Lewis, Penny M.; Sheridan, Leah Bullard; Gawley, Robert E.; Fritsch, Ingrid

    2010-01-01

    Amperometric detection at microelectrodes in lab-on-a-chip (LOAC) devices lose advantages in signal-to-background ratio, reduced ohmic iR drop, and steady-state signal when volumes are so small that diffusion fields reach the walls before flux becomes fully radial. Redox-cycling of electroactive species between multiple, closely-spaced microelectrodes offsets that limitation and provides amplification capabilities. A device that integrates a microchannel with an individually-addressable microband electrode array has been used to study effects of signal amplification due to redox cycling in a confined, static solution with different configurations and numbers of active generators and collectors. The microfabricated device consists of a 22-μm high, 600-μm wide microchannel containing an array of 50-μm wide, 600-μm long gold microbands, separated by 25-μm gaps, interspersed with an 800-μm-wide counter electrode and 400-μm wide passive conductor, with a distant but on-chip 400-μm wide pseudoreference electrode. Investigations involve solutions of potassium chloride electrolyte containing potassium ferrocyanide. Amplification factors were as high as 7.60, even with these microelectrodes of fairly large dimensions (which are generally less expensive, easier, and more reproducible to fabricate), because of the significant role that passive and active (instrumentally induced) redox-cycling plays in confined volumes of enclosed microchannels. The studies are useful in optimizing designs for LOAC-devices. PMID:20108925

  20. Re-evaluation of EMG-torque relation in chronic stroke using linear electrode array EMG recordings

    PubMed Central

    Bhadane, Minal; Liu, Jie; Rymer, W. Zev; Zhou, Ping; Li, Sheng

    2016-01-01

    The objective was to re-evaluate the controversial reports of EMG-torque relation between impaired and non-impaired sides using linear electrode array EMG recordings. Ten subjects with chronic stroke performed a series of submaximal isometric elbow flexion tasks. A 20-channel linear array was used to record surface EMG of the biceps brachii muscles from both impaired and non-impaired sides. M-wave recordings for bilateral biceps brachii muscles were also made. Distribution of the slope of the EMG-torque relations for the individual channels showed a quasi-symmetrical “M” shaped pattern. The lowest value corresponded to the innervation zone (IZ) location. The highest value from the slope curve for each side was selected for comparison to minimize the effect of electrode placement and IZ asymmetry. The slope was greater on the impaired side in 4 of 10 subjects. There were a weak correlation between slope ratio and strength ratio and a moderate to high correlation between slope ratio and M-wave ratio between two sides. These findings suggest that the EMG-torque relations are likely mediated and influenced by multiple factors. Our findings emphasize the importance of electrode placement and suggest the primary role of peripheral adaptive changes in the EMG-torque relations in chronic stroke. PMID:27349938

  1. Electrode array-eluted dexamethasone protects against electrode insertion trauma induced hearing and hair cell losses, damage to neural elements, increases in impedance and fibrosis: A dose response study.

    PubMed

    Bas, Esperanza; Bohorquez, Jorge; Goncalves, Stefania; Perez, Enrique; Dinh, Christine T; Garnham, Carolyn; Hessler, Roland; Eshraghi, Adrien A; Van De Water, Thomas R

    2016-07-01

    We evaluated the effects of dexamethasone base (DXMb) containing electrode arrays in a guinea pig model of cochlear implantation to determine if eluted DXMb could protect the cochlea against electrode insertion trauma (EIT)-induced: 1) loss of hair cells; 2) disruption of neural elements; 3) increases in hearing thresholds; 4) increased electrical impedance and 5) fibrosis. A guinea pig model of EIT-induced hearing and hair cell losses was used to test silicone electrode arrays that contained either 10%, 1%, 0.1%, or 0% levels of micronized DXMb. These four types of electrode arrays were implanted into the scala tympani via basal turn cochleostomies and left in place for 3 months. Hearing thresholds were determined by ABR and CAP recordings in response to a series of defined pure tone stimuli (i.e. 16-0.5 kHz). Changes in impedance were measured between the implant electrode and a reference electrode. Hair cell counts and neural element integrity were determined by confocal microscopy analyses of stained organ of Corti whole mounts obtained from 90 day post-implantation animals. Fibrosis was measured in Masson trichrome stained cross-sections through the organ of Corti. The results showed that either 10% or 1.0% DXMb eluting electrode arrays protected; hearing thresholds, hair cells, and neural elements against EIT-induced losses and damage. Electrode arrays with 0.1% DXMb only partial protected against EIT-induced hearing loss and damage to the cochlea. Protection of hearing thresholds and organ of Corti sensory elements by electrode-eluted DXMb was still apparent at 3 months post-EIT. All three concentrations of DXMb in the electrode arrays prevented EIT-induced increases in impedance. EIT-initiated fibrosis was significantly reduced within the implanted cochlea of the two DXMb concentrations tested. In conclusion, DXMb eluting electrodes protected the cochlea against long term increases in hearing thresholds, loss of hair cells, damage to neural elements and

  2. Fabrication of Mesoporous CoS2 Nanotube Arrays as the Counter Electrodes of Dye-Sensitized Solar Cells.

    PubMed

    Tsai, Jung-Che; Hon, Min-Hsiung; Leu, Ing-Chi

    2015-09-01

    Mesoporous cobalt sulfide nanotube arrays on FTO-coated glass were synthesized by combining three simple technologies: the selective etching of ZnO sacrificial templates, mesoporous Co3 O4 formation from cobalt-chelated chitosan, and ion-exchange reaction (IER). The mesoporous Co3 O4 nanotubes composed of the Co3 O4 nanoparticles possess a high surface area and are taken advantage for further removal of templates and IER. The morphologies and crystal structures of the CoS2 nanotube arrays were characterized by SEM, TEM, and XRD analyses. Their electrocatalytic properties were determined by electrochemical analyses including cyclic voltammetry measurements and Tafel polarization. The DSSCs assembled with a CoS2 counter electrode achieved a power conversion efficiency of 6.13 %, which was comparable to that of the DSSC with the Pt counter electrode (6.04 %). This indicates that the mesoporous CoS2 nanotube array can be a low-cost and efficient alternative for the reduction of electrolytes in DSSCs. PMID:26154709

  3. Impedance biosensor based on interdigitated electrode array for detection of E.coli O157:H7 in food products

    NASA Astrophysics Data System (ADS)

    Ghosh Dastider, Shibajyoti; Barizuddin, Syed; Dweik, Majed; Almasri, Mahmoud F.

    2012-05-01

    An impedance biosensor was designed, fabricated and tested for detection of viable Escherichia coli O157:H7 in food samples. This device consists of interdigitated microelectrode array (IDEA) fabricated using thin layer of sputtered gold, embedded under a polydimethylsiloxane (PDMS) microchannel. The array of electrodes is designed to detect viable EColi in different food products. The active surface area of the detection array was modified using goat anti-E.coli polyclonal IgG antibody. Contaminated food samples were tested by infusing the supernatant containing bacteria over the IDEA's, through the microchannel. Antibody-antigen binding on the electrodes results in impedance change. Four serial concentrations of E.coli contaminated food samples (3x102 CFUmL-1 to 3x105 CFUmL-1) were tested. The biosensor successfully detected the E.coli samples, with the lower detection limit being 3x103 CFUmL-1 (up to 3cells/μl). Comparing the test results with an IDEA impedance biosensor without microchannel (published elsewhere) indicates that this biosensor have two order of magnitude times higher sensitivity. The proposed biosensor provides qualitative and quantitative detection, and potentially could be used for detection of other type of bacteria by immobilizing the specific type of antibody.

  4. Matrix-addressable, active electrode arrays for neural stimulation using organic semiconductors—cytotoxicity and pilot experiments in vivo

    NASA Astrophysics Data System (ADS)

    Feili, Dara; Schuettler, Martin; Stieglitz, Thomas

    2008-03-01

    Organic field effect transistors can be integrated into micromachined polyimide-based neural stimulation electrode arrays in order to build active switching matrices. With this approach, a matrix of N × M electrode contacts requires only N + M interconnects to a stimulator when active switching elements are used instead of N × M interconnects. In this paper, we demonstrated that pentacene-based organic field effect transistors (OFETs) can be used to drive stimulation currents through neural electrodes in a physiological-like environment. In order to prove the general applicability as an implant material, the cytotoxicity of pentacene was evaluated with respect to potential effects on cell viability. The results of these tests indicate that extracts from pentacene inhibit neither proliferation nor metabolism of the tested mouse fibroblasts. However, some effect on cell spreading was observed when cells were in direct contact to pentacene for 48 h. In pilot experiments it was demonstrated for the very first time that pentacene transistors can be used as switching elements, acting as voltage-controlled current sources, capable of driving currents suitable for electrical stimulation of a peripheral nerve via a tripolar cuff electrode.

  5. Reliability of signals from a chronically implanted, silicon-based electrode array in non-human primate primary motor cortex.

    PubMed

    Suner, Selim; Fellows, Matthew R; Vargas-Irwin, Carlos; Nakata, Gordon Kenji; Donoghue, John P

    2005-12-01

    Multiple-electrode arrays are valuable both as a research tool and as a sensor for neuromotor prosthetic devices, which could potentially restore voluntary motion and functional independence to paralyzed humans. Long-term array reliability is an important requirement for these applications. Here, we demonstrate the reliability of a regular array of 100 microelectrodes to obtain neural recordings from primary motor cortex (MI) of monkeys for at least three months and up to 1.5 years. We implanted Bionic (Cyberkinetics, Inc., Foxboro, MA) silicon probe arrays in MI of three Macaque monkeys. Neural signals were recorded during performance of an eight-direction, push-button task. Recording reliability was evaluated for 18, 35, or 51 sessions distributed over 83, 179, and 569 days after implantation, respectively, using qualitative and quantitative measures. A four-point signal quality scale was defined based on the waveform amplitude relative to noise. A single observer applied this scale to score signal quality for each electrode. A mean of 120 (+/- 17.6 SD), 146 (+/- 7.3), and 119 (+/- 16.9) neural-like waveforms were observed from 65-85 electrodes across subjects for all recording sessions of which over 80% were of high quality. Quantitative measures demonstrated that waveforms had signal-to-noise ratio (SNR) up to 20 with maximum peak-to-peak amplitude of over 1200 microv with a mean SNR of 4.8 for signals ranked as high quality. Mean signal quality did not change over the duration of the evaluation period (slope 0.001, 0.0068 and 0.03; NS). By contrast, neural waveform shape varied between, but not within days in all animals, suggesting a shifting population of recorded neurons over time. Arm-movement related modulation was common and 66% of all recorded neurons were tuned to reach direction. The ability for the array to record neural signals from parietal cortex was also established. These results demonstrate that neural recordings that can provide movement

  6. Non-invasive long-term and real-time analysis of endocrine cells on micro-electrode arrays

    PubMed Central

    Raoux, Matthieu; Bornat, Yannick; Quotb, Adam; Catargi, Bogdan; Renaud, Sylvie; Lang, Jochen

    2012-01-01

    Non-invasive high-throughput and long-term monitoring of endocrine cells is important for drug research, phenotyping, tissue engineering and pre-transplantation quality control. Here we report a novel approach to obtain simultaneous long-term electrical recordings of different islet cell types using multi-electrode arrays. We implemented wavelet transforms to resolve the low signal/noise ratio inherent to these measurements and extracted on-line a signature specific of cell activity. The architecture employed allows multiplexing a large number of electrodes for high-throughput screening. This method should be of considerable advantage in endocrine research and may be extended to other excitable cells previously not accessible to the technique. PMID:22199167

  7. Highly-active oxygen evolution electrocatalyzed by a Fe-doped NiSe nanoflake array electrode.

    PubMed

    Tang, Chun; Asiri, Abdullah M; Sun, Xuping

    2016-03-25

    Alkaline water electrolysis offers a simple method for mass production of hydrogen but suffers from the sluggish kinetics of the anodic oxygen evolution reaction (OER), calling for the development of low-cost and durable oxygen evolution electrocatalysts with high activity. In this communication, we report a highly-active robust oxygen evolution electrode, developed by in situ hydrothermal growth of an Fe-doped NiSe nanoflake array directly on a macroporous FeNi foam (Fe-NiSe/FeNi foam). This electrode catalyzes the OER with an onset overpotential as low as 200 mV and needs overpotentials of 245 and 264 mV to achieve 50 and 100 mA cm(-2), respectively, in 1.0 M KOH. Remarkably, it is also highly robust to drive 500 and 1000 mA cm(-2) at overpotentials of 246 and 263 mV, respectively, in 30 wt% KOH. PMID:26935420

  8. Conformable actively multiplexed high-density surface electrode array for brain interfacing

    DOEpatents

    Rogers, John; Kim, Dae-Hyeong; Litt, Brian; Viventi, Jonathan

    2015-01-13

    Provided are methods and devices for interfacing with brain tissue, specifically for monitoring and/or actuation of spatio-temporal electrical waveforms. The device is conformable having a high electrode density and high spatial and temporal resolution. A conformable substrate supports a conformable electronic circuit and a barrier layer. Electrodes are positioned to provide electrical contact with a brain tissue. A controller monitors or actuates the electrodes, thereby interfacing with the brain tissue. In an aspect, methods are provided to monitor or actuate spatio-temporal electrical waveform over large brain surface areas by any of the devices disclosed herein.

  9. Effective blockage of the interfacial recombination process at TiO(2) nanowire array electrodes in dye-sensitized solar cells.

    PubMed

    Jiang, Dianlu; Hao, Yuanqiang; Shen, Rujuan; Ghazarian, Sevak; Ramos, Angela; Zhou, Feimeng

    2013-11-27

    Effective blockage of recombination electron transfer of a fast electron transfer redox couple (ferrocenium/ferrocene or Fc(+)/Fc) at TiO2 nanowire array electrodes is achieved by silanization of the dye loaded TiO2 nanowire array. FT-IR clearly shows the formation of polysiloxane network at fluorine doped tin electrodes covered with TiO2 nanowire arrays and the dye molecules. Compared to the commonly used TiO2 nanoparticle film electrodes, the TiO2 nanowire array has a more spatially accessible structure, facilitating the formation of uniform polysiloxane films. Energy-dispersive X-ray spectroscopy (EDS) also reveals the presence of Si over multiple spots at the cross sections of the silanized TiO2 nanowire array electrodes. As a result, a rather high open-cell voltage Voc (0.69 V) and an enhanced efficiency (0.749 %) for DSSC with the Fc(+)/Fc couple were obtained. Contrary to the passivated TiO2 nanoparticle film electrodes at which a complex, biphasic dependence of electron lifetime on Voc was observed, we recorded a logarithm linear dependence of the lifetime on Voc after the silanization treatment. The nanowire arrays with optimal salinization treatments afford a useful surface for the study of electron recombination and photovoltaic generation in DSSCs. PMID:24191693

  10. Enhanced photoelectrochemical water splitting from Si quantum dots/TiO{sub 2} nanotube arrays composite electrodes

    SciTech Connect

    Li, Zhong; Cui, Xiaoli; Hao, Hongchen; Lu, Ming; Lin, Yuehe

    2015-06-15

    Graphical abstract: Si quantum dots were firstly applied to modify TiO{sub 2} nanotubes and enhanced visible light response was demonstrated for the resulted Si QDs/TiO{sub 2} nanocomposite. Si QDs are promising in photoelectrochemical water splitting and photocatalysis since their low cost, abundance and environmentally-friendliness. - Highlights: • A novel nanocomposite Si QDs/TiO{sub 2} nanotubes was fabricated and characterized. • Enhanced photoelectrochemical water splitting was firstly demonstrated for Si QDs/TiO{sub 2}. • The visible light response of TiO{sub 2} increased with the presence of Si QDs. - Abstract: This work firstly introduced Si quantum dots (QDs) to modify TiO{sub 2} nanotube arrays for photoelectrochemical water splitting. A systematic study using surface and optical characterization tools reveals the nature of the combination of Si QDs and TiO{sub 2} nanotube arrays. Scanning electron microscopy and X-ray photoelectron spectroscopy results show that Si QDs were assembled on the surface of vertically aligned TiO{sub 2} nanotube arrays. The UV–vis diffuse reflectance spectra indicate the improved visible light absorbance. The enhanced photoelectrochemical water splitting was demonstrated under visible light illumination and the photocurrent density was 1.6 times larger than that of pristine TiO{sub 2} electrodes. Electrochemical impedance behavior was measured for the electrodes and the impedance is slightly reduced for the nanocomposite electrode with the presence of Si QDs. This work demonstrated that Si QDs would be a novel and effective choice for improving the utilization of visible light for TiO{sub 2} nanotubes.

  11. Hybrid core-shell nanowire electrodes utilizing vertically aligned carbon nanofiber arrays for high-performance energy storage

    NASA Astrophysics Data System (ADS)

    Klankowski, Steven Arnold

    Nanostructured electrode materials for electrochemical energy storage systems have been shown to improve both rate performance and capacity retention, while allowing considerably longer cycling lifetime. The nano-architectures provide enhanced kinetics by means of larger surface area, higher porosity, better material interconnectivity, shorter diffusion lengths, and overall mechanical stability. Meanwhile, active materials that once were excluded from use due to bulk property issues are now being examined in new nanoarchitecture. Silicon was such a material, desired for its large lithium-ion storage capacity of 4,200 mAh g-1 and low redox potential of 0.4 V vs. Li/Li+; however, a ˜300% volume expansion and increased resistivity upon lithiation limited its broader applications. In the first study, the silicon-coated vertically aligned carbon nanofiber (VACNF) array presents a unique core-shell nanowire (NW) architecture that demonstrates both good capacity and high rate performance. In follow-up, the Si-VACNFs NW electrode demonstrates enhanced power rate capabilities as it shows excellent storage capacity at high rates, attributed to the unique nanoneedle structure that high vacuum sputtering produces on the three-dimensional array. Following silicon's success, titanium dioxide has been explored as an alternative high-rate electrode material by utilizing the dual storage mechanisms of Li+ insertion and pseudocapacitance. The TiO 2-coated VACNFs shows improved electrochemical activity that delivers near theoretical capacity at larger currents due to shorter Li+ diffusion lengths and highly effective electron transport. A unique cell is formed with the Si-coated and TiO2-coated electrodes place counter to one another, creating the hybrid of lithium ion battery-pseudocapacitor that demonstrated both high power and high energy densities. The hybrid cell operates like a battery at lower current rates, achieving larger discharge capacity, while retaining one-third of

  12. A Spherical Electrode Array for the Detection of Stretched Induced Arrhythmias

    NASA Astrophysics Data System (ADS)

    Kieron, M. E.; Parker, K. P.; Wikswo, J. W.

    1997-11-01

    A heart tank containing electrodes positioned at the vertices of a icosahedron was built to measure the epicardial potentials from a perfused rabbit heart. From the isopotential maps, the electrical source can be deduced. In addition, an inverse calculation can be performed to determine the multipole components and, thus, the dipole origin via a least squares method. It is hypothesized that stretched induced foci are located in the Purkinje conductive system. To find these foci, we are developing a LabVIEW based data acquisition system and a spherical heart tank consisting of 126 electrodes to record the potentials around a rabbit heart. The unipolar electrodes are fabricated from 26 AWG Cu magnet wire on which Ag was plated then chlorided to produce nonpolarizable electrodes required for the low level signals. The signals are amplified and filtered prior to A/D conversion and subsequent source analysis with MATLAB. Biocompatibility, EM interference, grounding, and other design considerations will be addressed.

  13. High performance binderless TiO2 nanowire arrays electrode for lithium-ion battery

    NASA Astrophysics Data System (ADS)

    Li, Yueming; Lv, Xiaojun; Li, Jinghong

    2009-09-01

    Binderless lithium ion battery electrode fabricated by anodizing Ti foil, in which TiO2 nanowire serves as active materials and unreacted Ti foil as the current collector, exhibited high electrochemical performance.

  14. Planar multi-electrode array sensor for localized electrochemical corrosion detection

    DOEpatents

    Tormoen, Garth William; Brossia, Christopher Sean

    2014-01-07

    A planarized type of coupled multi-electrode corrosion sensing device. Electrode pads are fabricated on a thin backing, such as a thin film. Each pad has an associated electrical lead for connection to auxiliary electronic circuitry, which may include a resistor associated with each electrical pad. The design permits the device to be easily placed in small crevices or under coatings such as paint.

  15. Design and modeling of the trapezoidal electrodes array for electrets energy harvester

    NASA Astrophysics Data System (ADS)

    Ahmad, M. R.; Md Khir, M. H.; Dennis, J. O.

    2013-05-01

    Electrets-based electrostatic energy harvester for harvesting electrical energy from the ambient vibration is introduced and described in this paper. A new design of electrode structure called the trapezoidal electrodes and its electrets counterpart are designed, modeled and analyzed thoroughly to evaluate its performance. First, the theory is explained and the mathematical analysis is performed using Matlab/Simulink tool. Results of the analysis shows that the average output power harvested from the trapezoidal electrodes is ~1 mW from 20 Hz at 1 g inputs. Then, the 3D model of the electrodes and electrets structures are constructed, simulated and analyzed with Finite Element Modeling/Analysis (FEM/FEA) tool. Further, mechanical analysis carried out on the trapezoidal electrodes model indicates that it displaces laterally at 94 μm and resonates at 113 Hz whereas the electrostatic analysis unveils 1895 pC of charge density induced on the trapezoidal electrodes from 450 VDC electrets potential. The optimized parameters derive from the analyses are used as a reference for fabrication of MEMS (Micro Electro-Mechanical System) physical device on a standard CMOS process technology.

  16. Binary cobalt ferrite nanomesh arrays as the advanced binder-free electrode for applications in oxygen evolution reaction and supercapacitors

    NASA Astrophysics Data System (ADS)

    Liu, Li; Zhang, Huijuan; Mu, Yanping; Bai, Yuanjuan; Wang, Yu

    2016-09-01

    The porous CoFe2O4nanomesh arrays are successfully synthesized on nickel foam substrate through a high temperature and pressure hydrothermal method, following by the thermal post-treatment in air. The CoFe2O4 nanomesh arrays own numerous pores and large specific surface area, which is in favor of exposing more active sites. In consideration of the structural preponderances and versatility of the materials, the CoFe2O4 nanomesh arrays have been researched as the binder-free electrode materials for electrocatalysis and supercapacitors. When the CoFe2O4nanomesh arrays on nickel foam (CoFe2O4 NM-As/Ni) directly act as the free-binder catalyst toward catalyzing the oxygen evolution reaction (OER) of electrochemical water splitting, CoFe2O4 NM-As/Ni exhibits an admirable OER property with a low onset potential of 1.47 V(corresponding to the onset overpotential of 240 mV), a minimal overpotential (η10 = 253 mV), a small Tafel slope (44 mV dec-1), large anodic currents and long-term durability for 35 h in alkaline media. In addition, as an electrode of supercapacitors, CoFe2O4 NM-As/Ni obtains a desired specific capacitance (1426 F/g at the current density of 1 A/g), remarkable rate capability (1024 F/g at the current density of 20 A/g) and eminent capacitance retention (92.6% after 3000 cycles). The above results demonstrate the CoFe2O4 NM-As/Ni possesses great potential application in electrocatalysis and supercapacitors.

  17. α-Fe2O3@PANI Core-Shell Nanowire Arrays as Negative Electrodes for Asymmetric Supercapacitors.

    PubMed

    Lu, Xue-Feng; Chen, Xiao-Yan; Zhou, Wen; Tong, Ye-Xiang; Li, Gao-Ren

    2015-07-15

    Highly ordered three-dimensional α-Fe2O3@PANI core-shell nanowire arrays with enhanced specific areal capacity and rate performance are fabricated by a simple and cost-effective electrodeposition method. The α-Fe2O3@PANI core-shell nanowire arrays provide a large reaction surface area, fast ion and electron transfer, and good structure stability, which all are beneficial for improving the electrochemical performance. Here, high-performance asymmetric supercapacitors (ASCs) are designed using α-Fe2O3@PANI core-shell nanowire arrays as anode and PANI nanorods grown on carbon cloth as cathode, and they display a high volumetric capacitance of 2.02 mF/cm3 based on the volume of device, a high energy density of 0.35 mWh/cm3 at a power density of 120.51 mW/cm3, and very good cycling stability with capacitance retention of 95.77% after 10,000 cycles. These findings will promote the application of α-Fe2O3@PANI core-shell nanowire arrays as advanced negative electrodes for ASCs. PMID:26090902

  18. Generation of large-scale, barrier-free diffuse plasmas in air at atmospheric pressure using array wire electrodes and nanosecond high-voltage pulses

    SciTech Connect

    Teng, Yun; Li, Lee Liu, Yun-Long; Liu, Lun; Liu, Minghai

    2014-10-15

    This paper introduces a method to generate large-scale diffuse plasmas by using a repetition nanosecond pulse generator and a parallel array wire-electrode configuration. We investigated barrier-free diffuse plasmas produced in the open air in parallel and cross-parallel array line-line electrode configurations. We found that, when the distance between the wire-electrode pair is small, the discharges were almost extinguished. Also, glow-like diffuse plasmas with little discharge weakening were obtained in an appropriate range of line-line distances and with a cathode-grounding cross-electrode configuration. As an example, we produced a large-scale, stable diffuse plasma with volumes as large as 18 × 15 × 15 cm{sup 3}, and this discharge region can be further expanded. Additionally, using optical and electrical measurements, we showed that the electron temperature was higher than the gas temperature, which was almost the same as room temperature. Also, an array of electrode configuration with more wire electrodes had helped to prevent the transition from diffuse discharge to arc discharge. Comparing the current waveforms of configurations with 1 cell and 9 cells, we found that adding cells significantly increased the conduction current and the electrical energy delivered in the electrode gaps.

  19. Generation of large-scale, barrier-free diffuse plasmas in air at atmospheric pressure using array wire electrodes and nanosecond high-voltage pulses

    NASA Astrophysics Data System (ADS)

    Teng, Yun; Li, Lee; Liu, Yun-Long; Liu, Lun; Liu, Minghai

    2014-10-01

    This paper introduces a method to generate large-scale diffuse plasmas by using a repetition nanosecond pulse generator and a parallel array wire-electrode configuration. We investigated barrier-free diffuse plasmas produced in the open air in parallel and cross-parallel array line-line electrode configurations. We found that, when the distance between the wire-electrode pair is small, the discharges were almost extinguished. Also, glow-like diffuse plasmas with little discharge weakening were obtained in an appropriate range of line-line distances and with a cathode-grounding cross-electrode configuration. As an example, we produced a large-scale, stable diffuse plasma with volumes as large as 18 × 15 × 15 cm3, and this discharge region can be further expanded. Additionally, using optical and electrical measurements, we showed that the electron temperature was higher than the gas temperature, which was almost the same as room temperature. Also, an array of electrode configuration with more wire electrodes had helped to prevent the transition from diffuse discharge to arc discharge. Comparing the current waveforms of configurations with 1 cell and 9 cells, we found that adding cells significantly increased the conduction current and the electrical energy delivered in the electrode gaps.

  20. Branched zinc oxide nanorods arrays modified paper electrode for electrochemical immunosensing by combining biocatalytic precipitation reaction and competitive immunoassay mode.

    PubMed

    Sun, Guoqiang; Yang, Hongmei; Zhang, Yan; Yu, Jinghua; Ge, Shenguang; Yan, Mei; Song, Xianrang

    2015-12-15

    Branched zinc oxide nanorods (BZR) arrays, an array with high charge carries collection efficiency and specific surface area, are grown on the reduced graphene oxide-paper working electrode for the first time to construct a paper-based electrochemical (EC) immunosensor. Typically, the BZR are fabricated via a simple hydrothermal process, which can provide abundant sites for antibodies loading. By combining the large surface area of porous zinc oxide (PZS) and good biocompatibility of gold nanoparticles (AuNPs), PZS-AuNPs (PZS@Au) nanocomposites are designed to label horseradish peroxide (HRP) and antigens. After a competitive reaction between antigens and PZS@Au nanocomposites labeled antigens, the signal labels are introduced into the immunosensor, in which, HRP participate in biocatalytic precipitation process. The produced precipitate reduces the electrode surface area and hinders the electron transfer. With the increase of concentration of antigens, the signal labels introduced into the sensor decrease, thus, a signal-on immunoassay for α-fetoprotein detection is constructed. The proposed paper-based EC immunosensor combines enzymatic biocatalytic precipitation reaction and competitive immunoassay mode for the first time, and possesses a wide linear range from 0.2 pg mL(-1) to 500 ng mL(-1) with a detection limit of 0.08 pg mL(-1). In addition, the proposed method is simple, sensitive and specific and can be a promising platform for other protein detection. PMID:26232677

  1. Virus enabled 3d nano-array electrodes for integrated Lithium/Sodium-ion microbatteries

    NASA Astrophysics Data System (ADS)

    Liu, Yihang

    Multilayers of functional materials (carbon/electrode/nickel) were hierarchically architectured over tobacco mosaic virus (TMV) templates that were genetically modified to self-assemble in a vertical manner on current-collectors for battery applications. The spaces formed between individual rods effectively accommodated the volume expansion and contraction of electrodes during charge/discharge, while surface carbon coating engineered over these nanorods further enhance the electronic conductivity. The microbattery based on self aligned nanoforests with precise arrangement of various auxiliary material layers including a central nanometric metal core as direct electronic pathway to current collector, can deliver high energy density and stable cycling stability. C/LiFePO4/Ni/TMV nanoforest cathodes for Li-ion batteries and C/Sn/Ni/TMV nanoforest anodes for Na-ion batteries were assembled using physical sputtering deposition. Both 3D nanoforest electrodes show exceptional cycling stability and rate capability.

  2. Lift-Off Free Fabrication Approach for Periodic Structures with Tunable Nano Gaps for Interdigitated Electrode Arrays.

    PubMed

    Partel, Stefan; Dincer, Can; Kasemann, Stephan; Kieninger, Jochen; Edlinger, Johannes; Urban, Gerald

    2016-01-26

    We report a simple, low-cost and lift-off free fabrication approach for periodic structures with adjustable nanometer gaps for interdigitated electrode arrays (IDAs). It combines an initial structure and two deposition process steps; first a dielectric layer is deposited, followed by a metal evaporation. The initial structure can be realized by lithography or any other structuring technique (e.g., nano imprint, hot embossing or injection molding). This method allows the fabrication of nanometer sized gaps and completely eliminates the need for a lift-off process. Different substrate materials like silicon, Pyrex or polymers can be used. The electrode gap is controlled primarily by sputter deposition of the initial structure, and thus, adjustable gaps in the nanometer range can be realized independently of the mask or stamp pattern. Electrochemical characterizations using redox cycling in ferrocenemethanol (FcMeOH) demonstrate signal amplification factors of more than 110 together with collection factors higher than 99%. Furthermore, the correlation between the gap width and the amplification factor was studied to obtain an electrochemical performance assessment of the nano gap electrodes. The results demonstrate an exponential relationship between amplification factor and gap width. PMID:26625012

  3. Flexible, high-density microphotodiode array with integrated sputtered iridium oxide electrodes for retinal stimulation

    NASA Astrophysics Data System (ADS)

    Yang, Frank; Chang, Mao-Yen; Yang, Chung-Hua; Teng, Chih-Ciao; Fan, Long-Sheng

    2016-01-01

    To assess the charge-injection capacity of the sputtered iridium oxide film (SIROF) electrode on the retinal CMOS image sensor (CIS) chip, a polyimide-based flex device was designed and fabricated to package the retinal CIS chip. The polyimide-flex-based packaging process keeps the surface of photosensors clean, and the measured connection resistance meets the packaging requirement of the low-power retinal CIS chip. The in vitro experimental results show that the small SIROF electrodes can provide a biphasic charge injection per phase of 3.9 nC/ph to achieve the stimulation threshold at a polarization potential of -0.44 V.

  4. Optimization of interdigitated electrode (IDE) arrays for impedance based evaluation of Hs 578T cancer cells

    NASA Astrophysics Data System (ADS)

    Alexander, Frank, Jr.; Price, Dorielle T.; Bhansali, Shekhar

    2010-04-01

    This paper examines the effect of electrode width and spacing of interdigitated electrodes (IDEs) for impedance-based cancer detection and characterization. IDEs are desired for bioimpedance measurements because their fabrication process is simple and inexpensive, and the geometry presents a potential for improved sensitivity over other microelectrode designs. Optimizing the geometry will eliminate this problem and increase the sensitivity of these devices for bioimpedance measurement applications. This paper evaluates the effect of IDE geometry on the sensitivity of breast cancer cell impedance measurements. Equivalent circuit data analysis was conducted to quantify and characterize the cells.

  5. Fabrication of Carbon-Platinum Interdigitated Array Electrodes and Their Application for Investigating Homogeneous Hydrogen Evolution Catalysis

    SciTech Connect

    Liu, Fei; Divan, Ralu; Parkinson, Bruce A.

    2015-06-29

    Carbon interdigitated array (IDA) electrodes have been applied to study the homogeneous hydrogen evolution electrocatalyst [Ni(PPh2NBn2)2]2+ (where PPh2NBn2 is 1,5-dibenzyl-3,7-diphenyl-1,5-diaza-3,7-diphosphacyclooctane). The existence of reaction intermediates in the catalytic cycle is inferred from the electrochemical behavior of a glassy carbon disk electrodes and carbon IDA electrodes. The currents on IDA electrodes for an EC’ (electron transfer reaction followed by a catalytic reaction) mechanism are derived from the number of redox cycles and the contribution of non-catalytic currents. The catalytic reaction rate constant was then extracted from the IDA current equations. Applying the IDA current and kinetic equations to the electrochemical response of the [Ni(PPh2NBn2)2]2+ catalyst yielded a rate constant of 0.10 s-1 for the hydrogen evolution reaction that agrees with the literature value. The quantitative analysis of IDA cyclic voltammetry can be used as a simple and straightforward method for determining rate constants in other catalytic systems. This work was supported as part of the Center for Molecular Electrocatalysis, an Energy Frontier Research Center funded by the Department of Energy, Office of Science, Office of Basic Energy Sciences. Pacific Northwest National Laboratory is operated by Battelle for DOE. Use of the Center for Nanoscale Materials was supported by the U.S. Department of Energy, Office of Science, Office of Basic Energy Sciences, under Contract No. DE-AC02-06CH11357.

  6. Tungsten trioxide nanoplate array supported platinum as a highly efficient counter electrode for dye-sensitized solar cells.

    PubMed

    Song, Dandan; Cui, Peng; Zhao, Xing; Li, Meicheng; Chu, Lihua; Wang, Tianyue; Jiang, Bing

    2015-03-19

    A tungsten trioxide (WO₃) nanoplate array is fabricated directly on the FTO/glass substrate and used as a platinum (Pt) nanoscale supporter for a highly efficient and low Pt-consumption counter electrode (CE) in dye-sensitized solar cells (DSCs). A Pt/WO₃ composite structure, with Pt nanoparticles having a diameter of 2-3 nm, increases the electrochemical catalytic activity in catalyzing the reduction of triiodide. Accordingly, the power conversion efficiency is increased from less than 1% for WO₃ CE and 8.1% for Pt CE, respectively, to 8.9% for Pt/WO₃ CE. Moreover, the use of Pt/WO₃ CE can dramatically reduce the consumption of scarce Pt material, with a relatively low Pt-loading of ∼2 μg cm(-2), while maintaining a much better performance. The excellent performance of Pt/WO₃ CE is attributed to the efficient electron injection and transport via WO₃ supporters, as well as the nanostructure array morphology of WO₃ for deposition of fine Pt nanoparticles. This work provides an approach for developing highly catalytic and low-cost Pt based CEs, which also has implications for the development of Pt/WO₃ nanoplate arrays for other applications. PMID:25743611

  7. Flexible coaxial-type fiber solid-state asymmetrical supercapacitor based on Ni3S2 nanorod array and pen ink electrodes

    NASA Astrophysics Data System (ADS)

    Wen, Jian; Li, Songzhan; Zhou, Kai; Song, Zengcai; Li, Borui; Chen, Zhao; Chen, Tian; Guo, Yaxiong; Fang, Guojia

    2016-08-01

    Fiber supercapacitors have attracted public attentions because of their merits of relatively high capacitance density, flexibility and easy integration with various electronic devices. In this work, a flexible coaxial-type fiber solid-state asymmetrical supercapacitor (ASC) based on Ni3S2 nanorod array electrode and pen ink electrode was successfully fabricated. The Ni3S2 nanorod array electrode was synthesized by directly growing Ni3S2 nanorod arrays on a nickel wire through a facile hydrothermal method and the pen ink electrode as negative electrode was synthesized by a simple dip-coating method. The solid-state ASC device presents a stable voltage window of 1.4 V and behaves a high specific capacitance of 34.9 F g-1 (87.25 F cm-1) at a scan rate of 10 mV s-1. Compared with the symmetric supercapacitor (SSC) based on Ni3S2 electrodes, the ASC device provide an increased energy density of 8.2 Wh kg-1 (0.81 mWh cm-3) at the power density of 214.6 W kg-1 (21.12 mW cm-3). In addition, the ASC device also exhibits excellent electrochemical stability with 93.1% of initial specific capacitance after 3000 consecutive cycles and good mechanical stability. These encouraging results present its great potential in flexible solid-state energy storage devices.

  8. Biocompatible MEMS electrode array for determination of three-dimensional strain.

    PubMed

    Evans, Boyd M; Mahfouz, Mohamed R; Pritchard, Emily R

    2006-01-01

    Sensor arrays for the measurement of the load condition of polyethylene spacers in the total knee arthroplasty (TKA) prosthesis have been developed. Arrays of capacitive sensors are used to determine the three-dimensional strain within the polyethylene prosthesis component. Data from these sensors can be used to give researchers better understanding of component motion, loading, and wear phenomena for a large range of activities. These sensors implemented on a large scale will give clinicians feedback for individual patient biomechanics without the requirement for patient exposure to X-ray radiation. Patients will benefit from smart prosthetic components which allow clinicians monitor biomechanics and loading by applying noninvasive remedies such as orthotics or physical therapy for patients exhibiting poor biomechanics before wear or component failure become issues. In this paper, we present research regarding the design of a biocompatible strain sensor and the fabrication of microelectrode arrays on biocompatible polymer materials. PMID:17946223

  9. Flexible gold electrode array for multiplexed immunoelectrochemical measurement of three protein biomarkers for prostate cancer.

    PubMed

    Liu, Jing; Lu, Cai-Yu; Zhou, Hong; Xu, Jing-Juan; Chen, Hong-Yuan

    2014-11-26

    In this work, we report a simple and novel electrochemical multiplexed immunosensor on a flexible polydimethylsiloxane (PDMS) slice deposited with 8 × 8 nano-Au film electrodes for simultaneous detection of prostate specific antigen (PSA), prostate specific membrane antigen (PSMA), and interleukin-6 (IL-6). Primary antibodies linked with magnetic beads (Ab1-MBs) were modified on the nano-Au film electrodes via magnetic force. In the presence of corresponding antigen, horse radish peroxidase-secondary antibody-conjugated gold nanorods (HRP-Ab2-gold NRs) were brought into the surface of electrodes, generating obvious electrochemical signals of H2O2 reduction reactions. Based on this, the designed immunosensor provide good performance in sensitivity and specificity during the detection of above three biomarkers for prostate cancer. The electrochemical multiplexed immunosensor was verified for selective and accurate detection of complex samples in human serum. Data suggested that the reported multiplexed immunosensing strategy holds great promise for applications in clinical assay and diseases diagnosis. PMID:25333408

  10. Carbon nanotube array based sensor

    DOEpatents

    Lee, Christopher L.; Noy, Aleksandr; Swierkowski, Stephan P.; Fisher, Karl A.; Woods, Bruce W.

    2005-09-20

    A sensor system comprising a first electrode with an array of carbon nanotubes and a second electrode. The first electrode with an array of carbon nanotubes and the second electrode are positioned to produce an air gap between the first electrode with an array of carbon nanotubes and the second electrode. A measuring device is provided for sensing changes in electrical capacitance between the first electrode with an array of carbon nanotubes and the second electrode.

  11. Insertion of linear 8.4 μm diameter 16 channel carbon fiber electrode arrays for single unit recordings

    NASA Astrophysics Data System (ADS)

    Patel, Paras R.; Na, Kyounghwan; Zhang, Huanan; Kozai, Takashi D. Y.; Kotov, Nicholas A.; Yoon, Euisik; Chestek, Cynthia A.

    2015-08-01

    Objective. Single carbon fiber electrodes (d = 8.4 μm) insulated with parylene-c and functionalized with PEDOT:pTS have been shown to record single unit activity but manual implantation of these devices with forceps can be difficult. Without an improvement in the insertion method any increase in the channel count by fabricating carbon fiber arrays would be impractical. In this study, we utilize a water soluble coating and structural backbones that allow us to create, implant, and record from fully functionalized arrays of carbon fibers with ˜150 μm pitch. Approach. Two approaches were tested for the insertion of carbon fiber arrays. The first method used a poly(ethylene glycol) (PEG) coating that temporarily stiffened the fibers while leaving a small portion at the tip exposed. The small exposed portion (500 μm-1 mm) readily penetrated the brain allowing for an insertion that did not require the handling of each fiber by forceps. The second method involved the fabrication of silicon support structures with individual shanks spaced 150 μm apart. Each shank consisted of a small groove that held an individual carbon fiber. Main results. Our results showed that the PEG coating allowed for the chronic implantation of carbon fiber arrays in five rats with unit activity detected at 31 days post-implant. The silicon support structures recorded single unit activity in three acute rat surgeries. In one of those surgeries a stacked device with three layers of silicon support structures and carbon fibers was built and shown to readily insert into the brain with unit activity on select sites. Significance. From these studies we have found that carbon fibers spaced at ˜150 μm readily insert into the brain. This greatly increases the recording density of chronic neural probes and paves the way for even higher density devices that have a minimal scarring response.

  12. Insertion of linear 8.4 μm diameter 16 channel carbon fiber electrode arrays for single unit recordings

    PubMed Central

    Patel, Paras R.; Na, Kyounghwan; Zhang, Huanan; Kozai, Takashi D. Y.; Kotov, Nicholas A.; Yoon, Euisik; Chestek, Cynthia A.

    2016-01-01

    Objective Single carbon fiber electrodes (d=8.4 μm) insulated with parylene-c and functionalized with PEDOT:pTS have been shown to record single unit activity but manual implantation of these devices with forceps can be difficult. Without an improvement in the insertion method any increase in the channel count by fabricating carbon fiber arrays would be impractical. In this study, we utilize a water soluble coating and structural backbones that allow us to create, implant, and record from fully functionalized arrays of carbon fibers with ~150 μm pitch. Approach Two approaches were tested for the insertion of carbon fiber arrays. The first method used a PEG coating that temporarily stiffened the fibers while leaving a small portion at the tip exposed. The small exposed portion (500 μm – 1 mm) readily penetrated the brain allowing for an insertion that did not require the handling of each fiber by forceps. The second method involved the fabrication of silicon support structures with individual shanks spaced 150 μm apart. Each shank consisted of a small groove that held an individual carbon fiber. Main results Our results showed that the PEG coating allowed for the chronic implantation of carbon fiber arrays in 5 rats with unit activity detected at 31 days post-implant. The silicon support structures recorded single unit activity in 3 acute rat surgeries. In one of those surgeries a stacked device with 3 layers of silicon support structures and carbon fibers was built and shown to readily insert into the brain with unit activity on select sites. Significance From these studies we have found that carbon fibers spaced at ~150 μm readily insert into the brain. This greatly increases the recording density of chronic neural probes and paves the way for even higher density devices that have a minimal scarring response. PMID:26035638

  13. High-performance supercapacitor electrodes based on hierarchical Ti@MnO(2) nanowire arrays.

    PubMed

    Zhu, Dongdong; Wang, Yadong; Yuan, Guoliang; Xia, Hui

    2014-03-18

    Ti nanowire arrays (NAs) prepared by a facile and template-free hydrothermal method were used as three-dimensional (3D) current collectors for the electrodeposition of MnO2. The resulting Ti@MnO2 NAs exhibit remarkable electrochemical behavior with high specific capacitance, good rate performance and desired cycling stability. PMID:24488182

  14. Automated lettuce nutrient solution management using an array of ion-selective electrodes

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Automated sensing and control of macronutrients in hydroponic solutions would allow more efficient management of nutrients for crop growth in closed systems. This paper describes the development and evaluation of a computer-controlled nutrient management system with an array of ion-selective electro...

  15. Percutaneous retrieval of a radiolucent anchoring sleeve embolized in pulmonary artery during pacemaker implantation.

    PubMed

    Tokuda, Michifumi; Yamane, Teiichi; Sadaoka, Shunichi; Tokutake, Kenichi; Yokoyama, Kenichi; Hioki, Mika; Narui, Ryohsuke; Tanigawa, Shinichi; Inada, Keiichi; Matsuo, Seiichiro; Yoshimura, Michihiro

    2016-08-01

    An 85-year-old female presented to our institution with symptomatic sick sinus syndrome. During pacemaker implantation, an anchoring sleeve in the right ventricular lead was embolized in the left pulmonary artery. Although the anchoring sleeve was radiolucent, digital subtraction angiography revealed an angiographic filling defect in the lower branch of the left pulmonary artery, and a snare catheter enabled the anchoring sleeve to be grasped and extracted. PMID:26391679

  16. Percutaneous Retrieval of a Radiolucent Foreign Body from an EVAR Device by Combining Different Image Modalities

    SciTech Connect

    Barbiero, Giulio; Cognolato, Diego; Polverosi, Roberta; Guarise, Alessandro

    2009-07-15

    Percutaneous extraction techniques are an established method for removing endovascular foreign bodies. Generally, the foreign body to be removed is radiopaque (i.e., catheter and guidewire fragments, vena cava filters, embolization coils, endovascular stents). We propose an application of these techniques to remove a radiolucent foreign body (i.e., pigtail cover) by means of a combination of different imaging techniques (fluoroscopy, digital subtraction angiography, ultrasound, and computed axial tomography).

  17. Observation of initial postoperative radiolucent lines using a modern pegged-glenoid design

    PubMed Central

    Everding, Nathan G.; Levy, Jonathan C.; Formaini, Nathan T.; Blum, Sara; Gil, Carlos C.; Verde, Kevin

    2016-01-01

    Purpose: Glenoid component loosening remains a common mode of failure for total shoulder arthroplasty and has inspired improvements in implant design, instrumentation, and surgical technique. The purpose of this manuscript was to evaluate the incidence of radiolucent lines and glenoid seating on initial postoperative radiographs using a modern pegged-glenoid design, instrumentation, and surgical technique. Materials and Methods: We performed a retrospective analysis of a consecutive series of 100 pegged-glenoid total shoulder replacements. In cases of excessive glenoid version, the glenoid was asymmetrically reamed to recreate more normal version. Initial postoperative radiographs were evaluated for the presence of radiolucent lines and completeness of glenoid seating. The preoperative glenoid version measured on axial computed tomography (CT) scans was used to compare differences in version among those with complete and incompletely seated glenoids. Results: The rate of radiolucent lines observed on postoperative radiographs was 0%. Complete glenoid seating (Grade A) was observed in 81 patients (observer 1) and 82 patients (observer 2). Measurements of preoperative CT scans found a higher percentage of abnormal glenoid version for incompletely seated glenoids (47%) than completely seated glenoids (34%) but no significant difference (P = 0.327). The mean preoperative glenoid retroversion for incompletely seated glenoids was 12.1° and 9.1° for completely seated glenoids (P = 0.263). Conclusions: Modern surgical techniques, surgical instrumentation, and peg glenoid design have facilitated the ability to eliminate radiolucent lines on initial postoperative radiographs with high rates of complete seating of glenoid components. Incomplete seating may be related to incomplete correction of glenoid version. PMID:27186058

  18. Laser Doppler flowmetry: an aid in differential diagnosis of apical radiolucencies.

    PubMed

    Chandler, N P; Love, R M; Sundqvist, G

    1999-05-01

    The case of a patient having 2 teeth with associated apical radiolucencies that responded to conventional pulp tests is presented. A decision was made to reexamine the patient at intervals rather than perform root canal treatment. During a recall visit, use of an available laser Doppler flowmeter allowed detection of blood flow within the affected teeth. A diagnosis of periapical cemental dysplasia (cementoma) was made. PMID:10348523

  19. Ordered Polypyrrole Nanowire Arrays Grown on a Carbon Cloth Substrate for a High-Performance Pseudocapacitor Electrode.

    PubMed

    Huang, Zi-Hang; Song, Yu; Xu, Xin-Xin; Liu, Xiao-Xia

    2015-11-18

    Highly aligned nanoarchitecture arrays directly grown on conducting substrates open up a new direction to accelerate Faradaic reactions for charge storage as well as address "dead volume" limitations for high-performance pseudocapacitor electrodes. Here we reported the electrochemical fabrication of well-ordered polypyrrole (PPy) nanowire arrays (NWAs) on surfaces of carbon fibers in an untreated carbon cloth to construct hierarchical structures constituted by the three-dimensional conductive carbon fiber skeleton and the atop well-ordered electroactive polymer nanowires. The morphologies, wetting behaviors, and charge-storage performances of the polymer were investigated by scanning electron microscopy, transmission electron microscopy, contact-angle measurement, cyclic voltammetry, galvanostatic charge-discharge, and electrochemical impedance spectroscopy. The well-ordered PPy NWA electrode exhibited a high specific capacitance of 699 F/g at 1 A/g with excellent rate capability, and 92.4% and 81.5% of its capacitance could be retained at 10 and 20 A/g, respectively. An extremely high energy density of 164.07 Wh/kg could be achieved by the PPy NWAs at a power density of 0.65 kW/kg. It also displayed a quite high energy density of 133.79 Wh/kg at a high power density of 13 kW/kg. The assembled symmetric supercapacitor of PPy NWAs//PPy NWAs also exhibited excellent rate capability, and only 19% of its energy density decreased when the power density increased 20 times from 0.65 to 13 kW/kg. PMID:26509281

  20. Development and Characterization of a Diamond-Insulated Graphitic Multi Electrode Array Realized with Ion Beam Lithography

    PubMed Central

    Picollo, Federico; Battiato, Alfio; Carbone, Emilio; Croin, Luca; Enrico, Emanuele; Forneris, Jacopo; Gosso, Sara; Olivero, Paolo; Pasquarelli, Alberto; Carabelli, Valentina

    2015-01-01

    The detection of quantal exocytic events from neurons and neuroendocrine cells is a challenging task in neuroscience. One of the most promising platforms for the development of a new generation of biosensors is diamond, due to its biocompatibility, transparency and chemical inertness. Moreover, the electrical properties of diamond can be turned from a perfect insulator into a conductive material (resistivity ∼mΩ·cm) by exploiting the metastable nature of this allotropic form of carbon. A 16-channels MEA (Multi Electrode Array) suitable for cell culture growing has been fabricated by means of ion implantation. A focused 1.2 MeV He+ beam was scanned on a IIa single-crystal diamond sample (4.5 × 4.5 × 0.5 mm3) to cause highly damaged sub-superficial structures that were defined with micrometric spatial resolution. After implantation, the sample was annealed. This process provides the conversion of the sub-superficial highly damaged regions to a graphitic phase embedded in a highly insulating diamond matrix. Thanks to a three-dimensional masking technique, the endpoints of the sub-superficial channels emerge in contact with the sample surface, therefore being available as sensing electrodes. Cyclic voltammetry and amperometry measurements of solutions with increasing concentrations of adrenaline were performed to characterize the biosensor sensitivity. The reported results demonstrate that this new type of biosensor is suitable for in vitro detection of catecholamine release. PMID:25558992

  1. Commercialisation of CMOS Integrated Circuit Technology in Multi-Electrode Arrays for Neuroscience and Cell-Based Biosensors

    PubMed Central

    Graham, Anthony H. D.; Robbins, Jon; Bowen, Chris R.; Taylor, John

    2011-01-01

    The adaptation of standard integrated circuit (IC) technology as a transducer in cell-based biosensors in drug discovery pharmacology, neural interface systems and electrophysiology requires electrodes that are electrochemically stable, biocompatible and affordable. Unfortunately, the ubiquitous Complementary Metal Oxide Semiconductor (CMOS) IC technology does not meet the first of these requirements. For devices intended only for research, modification of CMOS by post-processing using cleanroom facilities has been achieved. However, to enable adoption of CMOS as a basis for commercial biosensors, the economies of scale of CMOS fabrication must be maintained by using only low-cost post-processing techniques. This review highlights the methodologies employed in cell-based biosensor design where CMOS-based integrated circuits (ICs) form an integral part of the transducer system. Particular emphasis will be placed on the application of multi-electrode arrays for in vitro neuroscience applications. Identifying suitable IC packaging methods presents further significant challenges when considering specific applications. The various challenges and difficulties are reviewed and some potential solutions are presented. PMID:22163884

  2. Development and characterization of a diamond-insulated graphitic multi electrode array realized with ion beam lithography.

    PubMed

    Picollo, Federico; Battiato, Alfio; Carbone, Emilio; Croin, Luca; Enrico, Emanuele; Forneris, Jacopo; Gosso, Sara; Olivero, Paolo; Pasquarelli, Alberto; Carabelli, Valentina

    2015-01-01

    The detection of quantal exocytic events from neurons and neuroendocrine cells is a challenging task in neuroscience. One of the most promising platforms for the development of a new generation of biosensors is diamond, due to its biocompatibility, transparency and chemical inertness. Moreover, the electrical properties of diamond can be turned from a perfect insulator into a conductive material (resistivity ~mΩ·cm) by exploiting the metastable nature of this allotropic form of carbon. A 16‑channels MEA (Multi Electrode Array) suitable for cell culture growing has been fabricated by means of ion implantation. A focused 1.2 MeV He+ beam was scanned on a IIa single-crystal diamond sample (4.5 × 4.5 × 0.5 mm3) to cause highly damaged sub-superficial structures that were defined with micrometric spatial resolution. After implantation, the sample was annealed. This process provides the conversion of the sub-superficial highly damaged regions to a graphitic phase embedded in a highly insulating diamond matrix. Thanks to a three-dimensional masking technique, the endpoints of the sub-superficial channels emerge in contact with the sample surface, therefore being available as sensing electrodes. Cyclic voltammetry and amperometry measurements of solutions with increasing concentrations of adrenaline were performed to characterize the biosensor sensitivity. The reported results demonstrate that this new type of biosensor is suitable for in vitro detection of catecholamine release. PMID:25558992

  3. Carbon nanotube multi-electrode array chips for noninvasive real-time measurement of dopamine, action potentials, and postsynaptic potentials.

    PubMed

    Suzuki, Ikuro; Fukuda, Mao; Shirakawa, Keiichi; Jiko, Hideyasu; Gotoh, Masao

    2013-11-15

    Multi-electrode arrays (MEAs) can be used for noninvasive, real-time, and long-term recording of electrophysiological activity and changes in the extracellular chemical microenvironment. Neural network organization, neuronal excitability, synaptic and phenotypic plasticity, and drug responses may be monitored by MEAs, but it is still difficult to measure presynaptic activity, such as neurotransmitter release, from the presynaptic bouton. In this study, we describe the development of planar carbon nanotube (CNT)-MEA chips that can measure both the release of the neurotransmitter dopamine as well as electrophysiological responses such as field postsynaptic potentials (fPSPs) and action potentials (APs). These CNT-MEA chips were fabricated by electroplating the indium-tin oxide (ITO) microelectrode surfaces. The CNT-plated ITO electrode exhibited electrochemical response, having much higher current density compared with the bare ITO electrode. Chronoamperometric measurements using these CNT-MEA chips detected dopamine at nanomolar concentrations. By placing mouse striatal brain slices on the CNT-MEA chip, we successfully measured synaptic dopamine release from spontaneous firings with a high S/N ratio of 62. Furthermore, APs and fPSPs were measured from cultured hippocampal neurons and slices with high temporal resolution and a 100-fold greater S/N ratio. Our CNT-MEA chips made it possible to measure neurotransmitter dopamine (presynaptic activities), postsynaptic potentials, and action potentials, which have a central role in information processing in the neuronal network. CNT-MEA chips could prove useful for in vitro studies of stem cell differentiation, drug screening and toxicity, synaptic plasticity, and pathogenic processes involved in epilepsy, stroke, and neurodegenerative diseases. PMID:23774164

  4. Carbon nanotube-based multi electrode arrays for neuronal interfacing: progress and prospects

    PubMed Central

    Bareket-Keren, Lilach; Hanein, Yael

    2013-01-01

    Carbon nanotube (CNT) coatings have been demonstrated over the past several years as a promising material for neuronal interfacing applications. In particular, in the realm of neuronal implants, CNTs have major advantages owing to their unique mechanical and electrical properties. Here we review recent investigations utilizing CNTs in neuro-interfacing applications. Cell adhesion, neuronal engineering and multi electrode recordings with CNTs are described. We also highlight prospective advances in this field, in particular, progress toward flexible, bio-compatible CNT-based technology. PMID:23316141

  5. Analysis of neuronal cells of dissociated primary culture on high-density CMOS electrode array.

    PubMed

    Matsuda, Eiko; Mita, Takeshi; Hubert, Julien; Bakkum, Douglas; Frey, Urs; Hierlemann, Andreas; Takahashi, Hirokazu; Ikegami, Takashi

    2013-01-01

    Spontaneous development of neuronal cells was recorded around 4-34 days in vitro (DIV) with high-density CMOS array, which enables detailed study of the spatio-temporal activity of neuronal culture. We used the CMOS array to characterize the evolution of the inter-spike interval (ISI) distribution from putative single neurons, and estimate the network structure based on transfer entropy analysis, where each node corresponds to a single neuron. We observed that the ISI distributions gradually obeyed the power law with maturation of the network. The amount of information transferred between neurons increased at the early stage of development, but decreased as the network matured. These results suggest that both ISI and transfer entropy were very useful for characterizing the dynamic development of cultured neural cells over a few weeks. PMID:24109870

  6. Performance and Durability of Thin Film Thermocouple Array on a Porous Electrode.

    PubMed

    Guk, Erdogan; Ranaweera, Manoj; Venkatesan, Vijay; Kim, Jung-Sik

    2016-01-01

    Management of solid oxide fuel cell (SOFC) thermal gradients is vital to limit thermal expansion mismatch and thermal stress. However, owing to harsh operation conditions of SOFCs and limited available space in stack configuration, the number of techniques available to obtain temperature distribution from the cell surface is limited. The authors previously developed and studied a thermocouple array pattern to detect surface temperature distribution on an SOFC in open circuit conditions. In this study, the performance in terms of mechanical durability and oxidation state of the thin film thermoelements of the thermocouple array on the porous SOFC cathode is investigated. A thin-film multi-junction thermocouple array was sputter deposited using a magnetron sputter coater. Scanning electron microscopy (SEM) and X-ray photoelectron spectroscopy (XPS) characterisation techniques were carried out to understand characteristics of the thin film before and after temperature (20 °C-800 °C) measurement. Temperature readings from the sensor agreed well with the closely placed commercial thermocouple during heating segments. However, a sensor failure occurred at around 350 °C during the cooling segment. The SEM and XPS tests revealed cracks on the thin film thermoelements and oxidation to the film thickness direction. PMID:27563893

  7. Backside illuminated dye-sensitized solar cells based on titania nanotube array electrodes

    NASA Astrophysics Data System (ADS)

    Paulose, Maggie; Shankar, Karthik; Varghese, Oomman K.; Mor, Gopal K.; Hardin, Brian; Grimes, Craig A.

    2006-03-01

    Backside illuminated solar cells based on 6 µm long highly-ordered nanotube-array films sensitized by a self-assembled monolayer of bis(tetrabutylammonium)-cis-(dithiocyanato)- N,N'-bis(4-carboxylato-4'-carboxylic acid-2, 2'-bipyridine)ruthenium(II) (commonly called 'N719') show a short-circuit current density of 8.79 mA cm-2, 841 mV open circuit potential and a 0.57 fill factor yielding a power conversion efficiency of 4.24% under AM 1.5 sun. The solvent used to infiltrate the dye into the nanotube arrays, made by potentiostatic anodization of a titanium foil, was found to significantly influence the electrical characteristics of the resulting solar cell. A superior photoresponse was obtained with acetonitrile as the dye solvent. This is attributed to the improved wetting characteristics of the dye solution in acetonitrile enabling self-assembled monolayers with higher surface coverage to be formed inside the nanotubes. In comparison to nanocrystalline films, the nanotube-array films consistently exhibit larger open circuit photovoltage values; the origins of this enhancement are discussed.

  8. Gold-coated carbon nanotube electrode arrays: Immunosensors for impedimetric detection of bone biomarkers.

    PubMed

    Ramanathan, Madhumati; Patil, Mitali; Epur, Rigved; Yun, Yeoheung; Shanov, Vasselin; Schulz, Mark; Heineman, William R; Datta, Moni K; Kumta, Prashant N

    2016-03-15

    C-terminal telopeptide (cTx), a fragment generated during collagen degradation, is a key biomarker of bone resorption during the bone remodeling process. The presence of varying levels of cTx in the bloodstream can hence be indicative of abnormal bone metabolism. This study focuses on the development of an immunosensor utilizing carbon nanotube (CNT) electrodes coated with gold nanoparticles for the detection of cTx, which could ultimately lead to the development of an inexpensive and rapid point-of-care (POC) tool for bone metabolism detection and prognostics. Electrochemical impedance spectroscopy (EIS) was implemented to monitor and detect the antigen-antibody binding events occurring on the surface of the gold-deposited CNT electrode. Type I cTx was used as the model protein to test the developed sensor. The sensor was accordingly characterized at various stages of development for evaluation of the optimal sensor performance. The biosensor could detect cTx levels as low as 0.05 ng/mL. The feasibility of the sensor for point-of-care (POC) applications was further demonstrated by determining the single frequency showing maximum changes in impedance, which was determined to be 18.75 Hz. PMID:26476598

  9. Preparation of CuInS{sub 2}/TiO{sub 2} nanotube heterojunction arrays electrode and investigation of its photoelectrochemical properties

    SciTech Connect

    Li, Tingting; Li, Xinyong; Zhao, Qidong; Teng, Wei

    2014-11-15

    Graphical abstract: Schematic illustration of the synthesis steps of CuInS{sub 2}/TiO{sub 2} heterojunction arrays electrode. - Highlights: • CuInS{sub 2}/TiO{sub 2} nanotube heterojunction arrays electrode was successfully fabricated via a modified SILAR method. • Morphology, chemical compositions and the photoelectrochemical properties were studied. • The formed heterojunction structure is demonstrated as n–n type heterojunction. - Abstract: CuInS{sub 2}/TiO{sub 2} nanotube heterojunction arrays electrode was synthesized via a modified successive ionic layer adsorption and reaction (SILAR) method. The morphology, crystalline structure and chemical composition of the composite electrode were characterized with field-emission scanning electron microscopy (SEM), X-ray diffraction (XRD) and X-ray photoelectron spectra (XPS), respectively. The optical properties were investigated by UV–vis diffusion reflection spectra (DRS) and photoluminescence (PL) spectra as well as the photoelectrochemical measurements. Significantly enhanced photoelectrochemical properties of CuInS{sub 2}/TiO{sub 2} NTs electrode were observed under visible light irradiation, which could be attributed to the high absorption coefficient of CuInS{sub 2} in visible region and the heterostructure formed between CuInS{sub 2} and TiO{sub 2}.

  10. Effects of Nanowire Length and Surface Roughness on the Electrochemical Sensor Properties of Nafion-Free, Vertically Aligned Pt Nanowire Array Electrodes.

    PubMed

    Li, Zhiyang; Leung, Calvin; Gao, Fan; Gu, Zhiyong

    2015-01-01

    In this paper, vertically aligned Pt nanowire arrays (PtNWA) with different lengths and surface roughnesses were fabricated and their electrochemical performance toward hydrogen peroxide (H₂O₂) detection was studied. The nanowire arrays were synthesized by electroplating Pt in nanopores of anodic aluminum oxide (AAO) template. Different parameters, such as current density and deposition time, were precisely controlled to synthesize nanowires with different surface roughnesses and various lengths from 3 μm to 12 μm. The PtNWA electrodes showed better performance than the conventional electrodes modified by Pt nanowires randomly dispersed on the electrode surface. The results indicate that both the length and surface roughness can affect the sensing performance of vertically aligned Pt nanowire array electrodes. Generally, longer nanowires with rougher surfaces showed better electrochemical sensing performance. The 12 μm rough surface PtNWA presented the largest sensitivity (654 μA·mM⁻¹·cm⁻²) among all the nanowires studied, and showed a limit of detection of 2.4 μM. The 12 μm rough surface PtNWA electrode also showed good anti-interference property from chemicals that are typically present in the biological samples such as ascorbic, uric acid, citric acid, and glucose. The sensing performance in real samples (river water) was tested and good recovery was observed. These Nafion-free, vertically aligned Pt nanowires with surface roughness control show great promise as versatile electrochemical sensors and biosensors. PMID:26404303

  11. Effects of Nanowire Length and Surface Roughness on the Electrochemical Sensor Properties of Nafion-Free, Vertically Aligned Pt Nanowire Array Electrodes

    PubMed Central

    Li, Zhiyang; Leung, Calvin; Gao, Fan; Gu, Zhiyong

    2015-01-01

    In this paper, vertically aligned Pt nanowire arrays (PtNWA) with different lengths and surface roughnesses were fabricated and their electrochemical performance toward hydrogen peroxide (H2O2) detection was studied. The nanowire arrays were synthesized by electroplating Pt in nanopores of anodic aluminum oxide (AAO) template. Different parameters, such as current density and deposition time, were precisely controlled to synthesize nanowires with different surface roughnesses and various lengths from 3 μm to 12 μm. The PtNWA electrodes showed better performance than the conventional electrodes modified by Pt nanowires randomly dispersed on the electrode surface. The results indicate that both the length and surface roughness can affect the sensing performance of vertically aligned Pt nanowire array electrodes. Generally, longer nanowires with rougher surfaces showed better electrochemical sensing performance. The 12 μm rough surface PtNWA presented the largest sensitivity (654 μA·mM−1·cm−2) among all the nanowires studied, and showed a limit of detection of 2.4 μM. The 12 μm rough surface PtNWA electrode also showed good anti-interference property from chemicals that are typically present in the biological samples such as ascorbic, uric acid, citric acid, and glucose. The sensing performance in real samples (river water) was tested and good recovery was observed. These Nafion-free, vertically aligned Pt nanowires with surface roughness control show great promise as versatile electrochemical sensors and biosensors. PMID:26404303

  12. ITO@Cu2S tunnel junction nanowire arrays as efficient counter electrode for quantum-dot-sensitized solar cells.

    PubMed

    Jiang, Yan; Zhang, Xing; Ge, Qian-Qing; Yu, Bin-Bin; Zou, Yu-Gang; Jiang, Wen-Jie; Song, Wei-Guo; Wan, Li-Jun; Hu, Jin-Song

    2014-01-01

    Quantum-dot-sensitized solar cell (QDSSC) has been considered as an alternative to new generation photovoltaics, but it still presents very low power conversion efficiency. Besides the continuous effort on improving photoanodes and electrolytes, the focused investigation on charge transfer at interfaces and the rational design for counter electrodes (CEs) are recently receiving much attention. Herein, core-shell nanowire arrays with tin-doped indium oxide (ITO) nanowire core and Cu2S nanocrystal shell (ITO@Cu2S) were dedicatedly designed and fabricated as new efficient CEs for QDSSCs in order to improve charge collection and transport and to avoid the intrinsic issue of copper dissolution in popular and most efficient Cu/Cu2S CEs. The high-quality tunnel junctions formed between n-type ITO nanowires and p-type Cu2S nanocrystals led to the considerable decrease in sheet resistance and charge transfer resistance and thus facilitated the electron transport during the operation of QDSSCs. The three-dimensional structure of nanowire arrays provided high surface area for more active catalytic sites and easy accessibility for an electrolyte. As a result, the power conversion efficiency of QDSSCs with the designed ITO@Cu2S CEs increased by 84.5 and 33.5% compared to that with planar Au and Cu2S CEs, respectively. PMID:24350879

  13. A flexible microneedle array as low-voltage electroporation electrodes for in vivo DNA and siRNA delivery.

    PubMed

    Wei, Zewen; Zheng, Shuquan; Wang, Renxin; Bu, Xiangli; Ma, Huailei; Wu, Yidi; Zhu, Ling; Hu, Zhiyuan; Liang, Zicai; Li, Zhihong

    2014-10-21

    In vivo electroporation is an appealing method to deliver nucleic acid into living tissues, but the clinical application of such a method was limited due to severe tissue damage and poor coverage of the tissue surface. Here we present the validation of a novel flexible microneedle array electrode (MNAE) chip, in which the microneedle array and the flexible substrate are integrated together to simultaneously facilitate low-voltage electroporation and accomplish good coverage of the tissue surface. The efficient delivery of both DNA and siRNA was demonstrated on mice. Upon penetrating the high-resistance stratum corneum, the electroporation voltage was reduced to about 35 V, which was generally recognized safe for humans. Also, a pathological analysis of the microneedle-electroporated tissues was carried out to thoroughly assess the skin damage, which is an important consideration in pre-clinical studies of electroporation devices. This MNAE constitutes a novel way of in vivo delivery of siRNA and DNA to certain tissues or organs with satisfactory efficiency and good adaptation to the tissue surface profile as well as minimum tissue damage, thus avoiding the disadvantages of existing electroporation methods. PMID:25182174

  14. Algorithm for real-time detection of signal patterns using phase synchrony: an application to an electrode array

    NASA Astrophysics Data System (ADS)

    Sadeghi, Saman; MacKay, William A.; van Dam, R. Michael; Thompson, Michael

    2011-02-01

    Real-time analysis of multi-channel spatio-temporal sensor data presents a considerable technical challenge for a number of applications. For example, in brain-computer interfaces, signal patterns originating on a time-dependent basis from an array of electrodes on the scalp (i.e. electroencephalography) must be analyzed in real time to recognize mental states and translate these to commands which control operations in a machine. In this paper we describe a new technique for recognition of spatio-temporal patterns based on performing online discrimination of time-resolved events through the use of correlation of phase dynamics between various channels in a multi-channel system. The algorithm extracts unique sensor signature patterns associated with each event during a training period and ranks importance of sensor pairs in order to distinguish between time-resolved stimuli to which the system may be exposed during real-time operation. We apply the algorithm to electroencephalographic signals obtained from subjects tested in the neurophysiology laboratories at the University of Toronto. The extension of this algorithm for rapid detection of patterns in other sensing applications, including chemical identification via chemical or bio-chemical sensor arrays, is also discussed.

  15. Fabrication process for CMUT arrays with polysilicon electrodes, nanometre precision cavity gaps and through-silicon vias

    NASA Astrophysics Data System (ADS)

    Due-Hansen, J.; Midtbø, K.; Poppe, E.; Summanwar, A.; Jensen, G. U.; Breivik, L.; Wang, D. T.; Schjølberg-Henriksen, K.

    2012-07-01

    Capacitive micromachined ultrasound transducers (CMUTs) can be used to realize miniature ultrasound probes. Through-silicon vias (TSVs) allow for close integration of the CMUT and read-out electronics. A fabrication process enabling the realization of a CMUT array with TSVs is being developed. The integrated process requires the formation of highly doped polysilicon electrodes with low surface roughness. A process for polysilicon film deposition, doping, CMP, RIE and thermal annealing that resulted in a film with sheet resistance of 4.0 Ω/□ and a surface roughness of 1 nm rms has been developed. The surface roughness of the polysilicon film was found to increase with higher phosphorus concentrations. The surface roughness also increased when oxygen was present in the thermal annealing ambient. The RIE process for etching CMUT cavities in the doped polysilicon gave a mean etch depth of 59.2 ± 3.9 nm and a uniformity across the wafer ranging from 1.0 to 4.7%. The two presented processes are key processes that enable the fabrication of CMUT arrays suitable for applications in for instance intravascular cardiology and gastrointestinal imaging.

  16. Sensitive high-performance liquid chromatographic method for profiling phytoestrogens using coulometric electrode array detection: application to plasma analysis.

    PubMed

    Nurmi, T; Adlercreutz, H

    1999-10-01

    An HPLC method for profiling 13 phytoestrogens and their metabolites using coulometric electrode array detection was developed. Sensitivity of the method was slightly less than that of our GC-MS method, but significantly higher compared to the HPLC methods using diode-array or UV detection. Detection limits varied from 3.4 (secoisolariciresinol) to 40.3 (genistin) pg on column. Signal linearities ranged from the detection limits to 61 ng on column. Resolution values for the peak pairs varied from 1.1 (O-desmethylangolensin-anhydrosecoisolariciresinol) to 16 (daidzin-genistin). Intra- and interassay retention time variations were negligible and detector response variation was eliminated by frequent calibration. Chromatographic method was applied to plasma analyses and 6 of the 13 compounds were detected. Method accuracy for those six analytes varied from 69% (enterodiol) to 118% (genistein). Intraassay precision CVs ranged from 1.5% (enterolactone, 12.4 nmol/liter) to 14% (genistein, 245 nmol/liter) and interassay precision CVs ranged from 9.9% (daidzein, 67.4 nmol/liter) to 44% (enterodiol, 1.20 nmol/liter). PMID:10527503

  17. Radiolucent lines in low-contact-stress mobile-bearing total knee arthroplasty: a blinded and matched case control study

    PubMed Central

    2011-01-01

    Background Low-contact-stress (LCS) mobile-bearing total knee arthroplasty (TKA) (Johnson & Johnson, New Brunswick, NJ; previously: DePuy, Warsawa, USA) provides excellent functional results and wear rates in long-term follow-up analyses. Radiological analysis shows radiolucent lines (RLL) appearing immediately or two years after primary implantation, indicative of poor seat. Investigations proved RLL to be more frequent in uncemented TKA, resulting in a consensus to cement the tibial plateau, but their association with clinical findings and patients discomfort and knee pain is still unknown. Methods 553 patients with 566 low-contact-stress (LCS) total knee prostheses were screened for continuous moderate knee pain. We compared tibial stress shielding classified by Ewald in patients suffering from pain with a matched, pain-free control group on blinded X-rays. We hypothesized a positive correlation between pain and radiolucency and higher frequency of such radiolucent lines in the most medial and most lateral zones of the tibial plateau. Results Twenty-eight patients suffered from knee pain in total. Radiolucencies were detected in 27 of these cases and in six out of 28 matched controls without knee pain. We could demonstrate a significant correlation of knee pain and radiolucencies, which appeared significantly more frequently in the outermost zones of the tibial plateau. Conclusion Our findings suggest that radiolucent lines, representing poor implant seat, about the tibial plateau are associated with knee pain in LCS patients. Radiolucencies are observed more often in noncemented LCS, and cementing the tibial plateau might improve implant seat and reduce both radiolucent lines and associated knee pain. PMID:21714916

  18. Conservative management of dens evaginatus and attached supernumerary tooth/odontome in mandibular premolar with dual radiolucencies

    PubMed Central

    Shah, Naseem; Jadhav, Ganesh Ranganath; Mittal, Priya; Logani, Ajay

    2015-01-01

    Recently, an innovative, nonsurgical regenerative endodontic treatment protocol “SealBio” was introduced to manage mature nonvital permanent teeth with periapical lesions. This paper explains the management of an unusual case of dens evaginatus and an attached supernumerary tooth/an odontome associated with two distinct radiolucencies in a mandibular premolar with “SealBio” technique and discusses the various hypotheses on the pathogenesis of unusual malformation and associated pericervical cyst-like radiolucency in the involved tooth. PMID:26604586

  19. Effect of matrix on the electrochemical characteristics of TiO₂ nanotube array-based PbO₂ electrode for pollutant degradation.

    PubMed

    Hu, Zhongxin; Zhou, Minghua; Zhou, Lei; Li, Yunlin; Zhang, Chao

    2014-01-01

    A series of lead dioxide electrodes developed on titania nanotube arrays with different matrix were fabricated by electrodeposition. Before the deposition of PbO₂, the matrix of this anode was electrochemically reduced in (NH₄)₂SO₄ solution and/or pre-deposited with certain amounts of copper. To gain insight into these pretreatments, the PbO₂ electrodes were characterized by SEM, LSV, and XRD, and their electrocatalytic activities for pollutant degradation were compared using p-nitrophenol (p-NP) as a model. It was confirmed that the electrochemical reduction with (NH4)₂SO₄ resulted in the partial conversion of TiO₂ into Ti₄O₇ and Ti₅O₉, which increased the conductivity of PbO₂ anode, but decreased its electrochemical activity, while the Ti/TNTs*-Cu/PbO₂ electrode with both pretreatments possessed the highest oxygen evolution overpotential of 2.5 V (vs. SCE) and low substrate resistance. After a 180-min treatment on this electrode, the removal efficiency of p-NP reached 82.5% and the COD removal achieved 42.5% with the energy consumption of 9.45 kWh m(-3), demonstrating the best performance among these electrodes with different matrices. Therefore, this titania nanotube array-based PbO₂ electrode has a promising application in the industrial wastewater treatment. PMID:24687791

  20. Study on the distortion of apparent resistivity curves caused by the 'infinite' electrode space of a Pole-Pole array and its correction

    NASA Astrophysics Data System (ADS)

    Xiao, Le-Le; Wei, Jiu-Chuan; Niu, Chao; Shi, Long-Qing; Zhai, Pei-He; Yin, Hui-Yong; Xie, Dao-Lei

    2015-07-01

    The Pole-Pole (PP) array is widely used for measurements that incorporate two-dimensional (2-D) and three-dimensional (3-D) multi-electrode electrical resistivity surveys, although an effective equilibrium has not yet been achieved between two factors, the location of 'infinite' electrodes and the data utilisation of the effective resistivity, which affects the detection accuracy; thus, the data collected under the conditions of 'infinite' electrodes that are as finite as possible are maximally effective. Studies have shown that the optimum 'infinite' electrode distance must be greater than 20 times the current-potential electrode distance AM; this value is much greater than the currently used value of 5 to 10 times AM. However, limitations imposed by landforms and topographic conditions, such as mountainous areas and coal mine roadways, often prevent the 'infinite' condition from being satisfied. In this study, a field test was designed and performed by adopting a particular PP array to collect sounding data under different 'infinite' electrode distances, and the differences were analysed in the apparent resistivity curves calculated with different geometric coefficients. The results reveal that when the 'infinite' electrode space is finite relative to AM, significant distortion may occur, and a minimum inflection point may appear in the sounding curve of apparent resistivity that is calculated with the geometric coefficient Kpp. Although the data past the minimum inflection point of ρs-mpp curve lose their value for the sounding application, a portion of the first segment of the distorted curve can be used, therefore, a correction formula under the condition of non-infinite electrode (Bing and Greenhalgh, 1998) space in a PP array is derived based on traditional electric field theories and formulas of apparent resistivity under different electrode arrays. The error analysis after correction indicates that the data utilisation ratio in the corrected effective

  1. A new method for fabricating a CuO/TiO2 nanotube arrays electrode and its application as a sensitive nonenzymatic glucose sensor.

    PubMed

    Luo, Shenglian; Su, Fang; Liu, Chengbin; Li, Juanxiu; Liu, Ronghua; Xiao, Yan; Li, Yue; Liu, Xuanneng; Cai, Qingyun

    2011-10-30

    In this report, we presented a new method to fabricate TiO(2) nanotube (TiO(2) NT) arrays modified with cupric oxide (CuO) nanofibers, getting a novel TiO(2) NT arrays composition electrode for sensitive nonenzymatic glucose detection. For the preparation of CuO nanofibers, Cu nanoparticles were firstly electrodeposited onto the TiO(2) NT arrays, and then oxidized to CuO nanofibers followed by annealing in air. The CuO nanofibers modified TiO(2) NT (CuO/TiO(2) NT) arrays electrode for electrocatalytic detection of glucose was investigated by cyclic voltammetry and chronoamperometry in 0.10 M NaOH solution. The linear range of detection of glucose extended up to 2.0mM (R=0.997, n=10) at a potential of 0.50 V (vs. SCE). The sensitivity was 79.79 μA cm(-2)mM(-1), and the detection limit was 1 μM (S/N=3). Significantly, the poisoning by chloride ion and the interferences from ascorbic acid, uric acid, lactose, sucrose, fructose and dopamine were negligible. Particularly, the CuO/TiO(2) NT arrays electrode showed excellent stability and repeatability over 1 month. The sensor was also investigated detecting glucose in human blood serum samples. PMID:22063525

  2. A flexible electrode array for muscle impedance measurements in the mouse hind limb: A tool to speed research in neuromuscular disease

    NASA Astrophysics Data System (ADS)

    Li, J.; Rutkove, S. B.

    2013-04-01

    Electrical impedance myography (EIM) is a bioelectrical impedance technique focused on the assessment of neuromuscular diseases using tetrapolar surface arrays. Recently, we have shown that reproducible and sensitive EIM measurements can be made on the gastrocnemius muscle of the mouse hind limb and that these are sensitive to disease alterations. A dedicated array would help speed data acquisition and provide additional sensitivity to disease-induced alterations. A flexible electrode array was developed with electrode sizes of 1mm × 1mm by Parlex, Inc. Tetrapolar electrode sets were arranged both parallel to (longitudinal) and orthogonally to (transverse) the major muscle fiber direction of the gastrocnemius muscle. Measurements were made with a dedicated EIM system. A total of 11 healthy animals and 7 animals with spinal muscular atrophy (a form of motor neuron disease) were evaluated after the fur was completely removed with a depilatory agent from the hind limb. Standard electrophysiologic testing (compound motor action potential amplitude and motor unit number estimation) was also performed. The flexible electrode array demonstrated high repeatability in both the longitudinal and transverse directions in the healthy and diseased animals (with intraclass correlation coefficients of 0.94 and 0.89, respectively, for phase angle measured transversely). In addition, differences between healthy and diseased animals were identifiable. For example, the 50 kHz transverse phase angle was higher in the healthy as compared to the SMA animals (16.8° ± 0.5 vs. 14.3° ± 0.7, respectively) at 21 weeks of age (p = 0.01). Differences in anisotropy were also identifiable. Correlations to several standard neurophysiologic parameters also appeared promising. This novel flexible tetrapolar electrode array can be used on the mouse hind limb and provides multidirectional data that can be used to assess muscle health. This technique has the potential of finding widespread use in

  3. Enhanced light emission in vertical-structured GaN-based light-emitting diodes with trench etching and arrayed p-electrodes

    NASA Astrophysics Data System (ADS)

    Lin, Tseng-Hsing; Wang, Shui-Jinn; Tu, Yung-Chun; Hung, Chien-Hsiung; Lin, Che-An; Lin, Yung-Cheng; You, Zong-Sian

    2015-05-01

    We investigate the effect of trench etching and arrayed p-electrodes in improving current spreading and the efficiency of light extraction of GaN-based vertical-structured light-emitting diodes (VLEDs). Both simulated and experimental results on the uniformities of current distribution and light emission are presented and discussed. For a 2 × 2 array VLED with a die size of 1020 × 1020 μm2, enhancements in light output power by 0.38% (6.03%) and wall-plug efficiency by 2.79% (2.32%) at 364.4 mA/mm2 (728.9 mA/mm2) as compared with that of regular VLED are achieved experimentally, which are attributed to improved current spreading from the arrayed p-electrode and trench designs as well as enhanced light emission from the trench region.

  4. Biaxially stretchable supercapacitors based on the buckled hybrid fiber electrode array.

    PubMed

    Zhang, Nan; Zhou, Weiya; Zhang, Qiang; Luan, Pingshan; Cai, Le; Yang, Feng; Zhang, Xiao; Fan, Qingxia; Zhou, Wenbin; Xiao, Zhuojian; Gu, Xiaogang; Chen, Huiliang; Li, Kewei; Xiao, Shiqi; Wang, Yanchun; Liu, Huaping; Xie, Sishen

    2015-08-01

    In order to meet the growing need for smart bionic devices and epidermal electronic systems, biaxial stretchability is essential for energy storage units. Based on porous single-walled carbon nanotube/poly(3,4-ethylenedioxythiophene) (SWCNT/PEDOT) hybrid fiber, we designed and fabricated a biaxially stretchable supercapacitor, which possesses a unique configuration of the parallel buckled hybrid fiber array. Owing to the reticulate SWCNT film and the improved fabrication technique, the hybrid fiber retained its porous architecture both outwardly and inwardly, manifesting a superior capacity of 215 F g(-1). H3PO4-polyvinyl alcohol gel with an optimized component ratio was introduced as both binder and stretchable electrolyte, which contributed to the regularity and stability of the buckled fiber array. The buckled structure and the quasi one-dimensional character of the fibers endow the supercapacitor with 100% stretchability along all directions. In addition, the supercapacitor exhibited good transparency, as well as excellent electrochemical properties and stability after being stretched 5000 times. PMID:26136109

  5. Decoding continuous limb movements from high-density epidural electrode arrays using custom spatial filters

    NASA Astrophysics Data System (ADS)

    Marathe, A. R.; Taylor, D. M.

    2013-06-01

    Objective. Our goal was to identify spatial filtering methods that would improve decoding of continuous arm movements from epidural field potentials as well as demonstrate the use of the epidural signals in a closed-loop brain-machine interface (BMI) system in monkeys. Approach. Eleven spatial filtering options were compared offline using field potentials collected from 64-channel high-density epidural arrays in monkeys. Arrays were placed over arm/hand motor cortex in which intracortical microelectrodes had previously been implanted and removed leaving focal cortical damage but no lasting motor deficits. Spatial filters tested included: no filtering, common average referencing (CAR), principle component analysis, and eight novel modifications of the common spatial pattern (CSP) algorithm. The spatial filtering method and decoder combination that performed the best offline was then used online where monkeys controlled cursor velocity using continuous wrist position decoded from epidural field potentials in real time. Main results. Optimized CSP methods improved continuous wrist position decoding accuracy by 69% over CAR and by 80% compared to no filtering. Kalman decoders performed better than linear regression decoders and benefitted from including more spatially-filtered signals but not from pre-smoothing the calculated power spectra. Conversely, linear regression decoders required fewer spatially-filtered signals and were improved by pre-smoothing the power values. The ‘position-to-velocity’ transformation used during online control enabled the animals to generate smooth closed-loop movement trajectories using the somewhat limited position information available in the epidural signals. The monkeys’ online performance significantly improved across days of closed-loop training. Significance. Most published BMI studies that use electrocorticographic signals to decode continuous limb movements either use no spatial filtering or CAR. This study suggests a

  6. Decoding continuous limb movements from high-density epidural electrode arrays using custom spatial filters

    PubMed Central

    Marathe, A R.; Taylor, D M

    2013-01-01

    Objective Our goal was to identify spatial filtering methods that would improve decoding of continuous arm movements from epidural field potentials as well as demonstrate the use of the epidural signals in a closed-loop brain-machine interface (BMI) system in monkeys. Approach Eleven spatial filtering options were compared offline using field potentials collected from 64-channel high-density epidural arrays in monkeys. Arrays were placed over arm/hand motor cortex in which intracortical microelectrodes had previously been implanted and removed leaving focal cortical damage but no lasting motor deficits. Spatial filters tested included: no filtering, common average referencing (CAR), principle component analysis (PCA), and eight novel modifications of the common spatial pattern (CSP) algorithm. The spatial filtering method and decoder combination that performed the best offline was then used online where monkeys controlled cursor velocity using continuous wrist position decoded from epidural field potentials in real time. Main results Optimized CSP methods improved continuous wrist position decoding accuracy by 69% over CAR and by 80% compared to no filtering. Kalman decoders performed better than linear regression decoders and benefitted from including more spatially-filtered signals but not from pre-smoothing the calculated power spectra. Conversely, linear regression decoders required fewer spatially-filtered signals and were improved by pre-smoothing the power values. The ‘position-to-velocity’ transformation used during online control enabled the animals to generate smooth closed-loop movement trajectories using the somewhat limited position information available in the epidural signals. The monkeys’ online performance significantly improved across days of closed-loop training. Significance Most published BMI studies that use electrocortographic signals to decode continuous limb movements either use no spatial filtering or CAR. This study suggests a

  7. Multi-electrode Array Recordings of Neuronal Avalanches in Organotypic Cultures

    PubMed Central

    Plenz, Dietmar; Stewart, Craig V.; Shew, Woodrow; Yang, Hongdian; Klaus, Andreas; Bellay, Tim

    2011-01-01

    The cortex is spontaneously active, even in the absence of any particular input or motor output. During development, this activity is important for the migration and differentiation of cortex cell types and the formation of neuronal connections1. In the mature animal, ongoing activity reflects the past and the present state of an animal into which sensory stimuli are seamlessly integrated to compute future actions. Thus, a clear understanding of the organization of ongoing i.e. spontaneous activity is a prerequisite to understand cortex function. Numerous recording techniques revealed that ongoing activity in cortex is comprised of many neurons whose individual activities transiently sum to larger events that can be detected in the local field potential (LFP) with extracellular microelectrodes, or in the electroencephalogram (EEG), the magnetoencephalogram (MEG), and the BOLD signal from functional magnetic resonance imaging (fMRI). The LFP is currently the method of choice when studying neuronal population activity with high temporal and spatial resolution at the mesoscopic scale (several thousands of neurons). At the extracellular microelectrode, locally synchronized activities of spatially neighbored neurons result in rapid deflections in the LFP up to several hundreds of microvolts. When using an array of microelectrodes, the organizations of such deflections can be conveniently monitored in space and time. Neuronal avalanches describe the scale-invariant spatiotemporal organization of ongoing neuronal activity in the brain2,3. They are specific to the superficial layers of cortex as established in vitro4,5, in vivo in the anesthetized rat 6, and in the awake monkey7. Importantly, both theoretical and empirical studies2,8-10 suggest that neuronal avalanches indicate an exquisitely balanced critical state dynamics of cortex that optimizes information transfer and information processing. In order to study the mechanisms of neuronal avalanche development

  8. Co(OH)2/RGO/NiO sandwich-structured nanotube arrays with special surface and synergistic effects as high-performance positive electrodes for asymmetric supercapacitors.

    PubMed

    Xu, Han; Zhang, Chi; Zhou, Wen; Li, Gao-Ren

    2015-10-28

    High power density, high energy density and excellent cycling stability are the main requirements for high-performance supercapacitors (SCs) that will be widely used for portable consumer electronics and hybrid electric vehicles. Here we investigate novel types of hybrid Co(OH)2/reduced graphene oxide (RGO)/NiO sandwich-structured nanotube arrays (SNTAs) as positive electrodes for asymmetric supercapacitors (ASCs). The synthesized Co(OH)2/RGO/NiO SNTAs exhibit a significantly improved specific capacity (∼1470 F g(-1) at 5 mV s(-1)) and excellent cycling stability with ∼98% Csp retention after 10 000 cycles because of the fast transport and short diffusion paths for electroactive species, the high utilization rate of electrode materials, and special synergistic effects among Co(OH)2, RGO, and NiO. The high-performance ASCs are assembled using Co(OH)2/RGO/NiO SNTAs as positive electrodes and active carbon (AC) as negative electrodes, and they exhibit a high energy density (115 Wh kg(-1)), a high power density (27.5 kW kg(-1)) and an excellent cycling stability (less 5% Csp loss after 10 000 cycles). This study shows an important breakthrough in the design and fabrication of multi-walled hybrid nanotube arrays as positive electrodes for ASCs. PMID:26416358

  9. Synthesis of visible-light absorbing CoFe{sub 2}O{sub 4} sensitized TiO{sub 2} nanotube arrays electrode with enhanced photoelectrochemical performance

    SciTech Connect

    Lei, Bing-Xin; Sun, Wei; Sun, Zhen-Fan

    2013-09-01

    Graphical abstract: - Highlights: • TiO{sub 2} nanotube sensitized with CoFe{sub 2}O{sub 4} nanocrystals was synthesized by a facile hydrothermal method. • CoFe{sub 2}O{sub 4} nanocrystals were loaded to the outer and inner surface of TiO{sub 2} nanotube. • The CoFe{sub 2}O{sub 4} sensitized TiO{sub 2} nanotube electrode has a strong photoresponse to the light. - Abstract: TiO{sub 2} nanotube arrays sensitized with CoFe{sub 2}O{sub 4} nanocrystals were successfully synthesized via a facile hydrothermal method. The as-prepared sample was studied by X-ray diffraction (XRD), field emission scanning electron microscopy (SEM), transmission electron microscopy (TEM), and energy-dispersive X-ray spectroscopy (EDX) to characterize its phase structure, morphology and chemical composition. Enhanced absorption in both UV and visible-light regions was observed for the CoFe{sub 2}O{sub 4} sensitized TiO{sub 2} nanotube arrays. The photocurrent density of CoFe{sub 2}O{sub 4} sensitized TiO{sub 2} nanotube arrays electrode was 30 times as great as that of bare TiO{sub 2} nanotube arrays electrode.

  10. Calibrated single-plunge bipolar electrode array for mapping myocardial vector fields in three dimensions during high-voltage transthoracic defibrillation.

    PubMed

    Deale, O C; Ng, K T; Kim-Van Housen, E J; Lerman, B B

    2001-08-01

    Mapping of the myocardial scalar electric potential during defibrillation is normally performed with unipolar electrodes connected to voltage dividers and a global potential reference. Unfortunately, vector potential gradients that are calculated from these data tend to exhibit a high sensitivity to measurement errors. This paper presents a calibrated single-plunge bipolar electrode array (EA) that avoids the error sensitivity of unipolar electrodes. The EA is triaxial, uses a local potential reference, and simultaneously measures all three components of the myocardial electric field vector. An electrode spacing of approximately 500 microm allows the EA to be direct-coupled to high-input-impedance, isolated, differential amplifiers and eliminates the need for voltage dividers. Calibration is performed with an electrolytic tank in which an accurately measured, uniform electric field is produced. For each EA, unique calibration matrices are determined which transform potential difference readings from the EA to orthogonal components of the electric field vector. Elements of the matrices are evaluated by least squares multiple regression analysis of data recorded during rotation of the electric field. The design of the electrolytic tank and electrode holder allows the electric field vector to be rotated globally with respect to the electrode axes. The calibration technique corrects for both field perturbation by the plunge electrode body and deviations from orthogonality of the electrode axes. A unique feature of this technique is that it eliminates the need for mechanical measurement of the electrode spacing. During calibration, only angular settings and voltages are recorded. For this study, ten EAs were calibrated and their root-mean-square (rms) errors evaluated. The mean of the vector magnitude rms errors over the set of ten EAs was 0.40% and the standard deviation 0.07%. Calibrated EAs were also tested for multisite mapping in four dogs during high

  11. Improvement of Electrical Stimulation Protocol for Simultaneous Measurement of Extracellular Potential with On-Chip Multi-Electrode Array System

    NASA Astrophysics Data System (ADS)

    Kaneko, Tomoyuki; Nomura, Fumimasa; Hattori, Akihiro; Yasuda, Kenji

    2012-06-01

    Cardiotoxicity testing with a multi-electrode array (MEA) system requires the stable beating of cardiomyocytes for the measurement of the field potential duration (FPD), because different spontaneous beating rates cause different responses of FPD prolongation induced by drugs, and the beating rate change effected by drugs complicates the FPD prolongation assessment. We have developed an on-chip MEA system with electrical stimulation for the measurement of the FPD during the stable beating of human embryonic stem (ES) cell-derived cardiomyocyte clusters. Using a conventional bipolar stimulation protocol, we observed such large artifacts in electrical stimulation that we could not estimate the FPD quantitatively. Therefore, we improved the stimulation protocol by using sequential rectangular pulses in which the positive and negative stimulation voltages and number of pulses could be changed flexibly. The balanced voltages and number of pulses for sequential rectangular pulses enabled the recording of small negative artifacts only, which hardly affected the FPD measurement of human-ES-cell-derived cardiomyocyte clusters. These conditions of electrical stimulation are expected to find applications for the control of constant beating for cardiotoxicity testing.

  12. Direct-current Stimulation and Multi-electrode Array Recording of Seizure-like Activity in Mice Brain Slice Preparation.

    PubMed

    Lu, Hsiang-Chin; Chang, Wei-Jen; Chang, Wei-Pang; Shyu, Bai-Chuang

    2016-01-01

    Cathodal transcranial direct-current stimulation (tDCS) induces suppressive effects on drug-resistant seizures. To perform effective actions, the stimulation parameters (e.g., orientation, field strength, and stimulation duration) need to be examined in mice brain slice preparations. Testing and arranging the orientation of the electrode relative to the position of the mice brain slice are feasible. The present method preserves the thalamocingulate pathway to evaluate the effect of DCS on anterior cingulate cortex seizure-like activities. The results of the multichannel array recordings indicated that cathodal DCS significantly decreased the amplitude of the stimulation-evoked responses and duration of 4-aminopyridine and bicuculline-induced seizure-like activity. This study also found that cathodal DCS applications at 15 min caused long-term depression in the thalamocingulate pathway. The present study investigates the effects of DCS on thalamocingulate synaptic plasticity and acute seizure-like activities. The current procedure can test the optimal stimulation parameters including orientation, field strength, and stimulation duration in an in vitro mouse model. Also, the method can evaluate the effects of DCS on cortical seizure-like activities at both the cellular and network levels. PMID:27341682

  13. Upper-limb stroke rehabilitation using electrode-array based functional electrical stimulation with sensing and control innovations.

    PubMed

    Kutlu, M; Freeman, C T; Hallewell, E; Hughes, A-M; Laila, D S

    2016-04-01

    Functional electrical stimulation (FES) has shown effectiveness in restoring upper-limb movement post-stroke when applied to assist participants' voluntary intention during repeated, motivating tasks. Recent clinical trials have used advanced controllers that precisely adjust FES to assist functional reach and grasp tasks with FES applied to three muscle groups, showing significant reduction in impairment. The system reported in this paper advances the state-of-the-art by: (1) integrating an FES electrode array on the forearm to assist complex hand and wrist gestures; (2) utilising non-contact depth cameras to accurately record the arm, hand and wrist position in 3D; and (3) employing an interactive touch table to present motivating virtual reality (VR) tasks. The system also uses iterative learning control (ILC), a model-based control strategy which adjusts the applied FES based on the tracking error recorded on previous task attempts. Feasibility of the system has been evaluated in experimental trials with 2 unimpaired participants and clinical trials with 4 hemiparetic, chronic stroke participants. The stroke participants attended 17, 1 hour training sessions in which they performed functional tasks, such as button pressing using the touch table and closing a drawer. Stroke participant results show that the joint angle error norm reduced by an average of 50.3% over 6 attempts at each task when assisted by FES. PMID:26947097

  14. CUSTOM-FIT RADIOLUCENT CRANIAL IMPLANTS FOR NEUROPHYSIOLOGICAL RECORDING AND STIMULATION

    PubMed Central

    Mulliken, Grant H; Bichot, Narcisse P; Ghadooshahy, Azriel; Sharma, Jitendra; Kornblith, Simon; Philcock, Michael; Desimone, Robert

    2015-01-01

    Background Recording and manipulating neural activity in awake behaving animal models requires long-term implantation of cranial implants that must address a variety of design considerations, which include preventing infection, minimizing tissue damage, mechanical strength of the implant, and MRI compatibility. New Method Here we address these issues by designing legless, custom-fit cranial implants using structural MRI-based reconstruction of the skull and that are made from carbon-reinforced PEEK. Results We report several novel custom-fit radiolucent implant designs, which include a legless recording chamber, a legless stimulation chamber, a multi-channel microdrive and a head post. The fit to the skull was excellent in all cases, with no visible gaps between the base of the implants and the skull. The wound margin was minimal in size and showed no sign of infection or skin recession. Comparison with Existing Methods Cranial implants used for neurophysiological investigation in awake behaving animals often employ methyl methacrylate (MMA) to serve as a bonding agent to secure the implant to the skull. Other designs rely on radially extending legs to secure the implant. Both of these methods have significant drawbacks. MMA is toxic to bone and frequently leads to infection while radially extending legs cause the skin to recede away from the implant, ultimately exposing bone and proliferating granulation tissue. Conclusions These radiolucent implants constitute a set of technologies suitable for reliable long-term recording, which minimize infection and tissue damage. PMID:25542350

  15. Radiolucent hair accessories causing depressed skull fracture following blunt cranial trauma.

    PubMed

    Syed, Omar N; Hankinson, Todd C; Mack, William J; Feldstein, Neil A; Anderson, Richard C E

    2008-12-01

    Pediatric neurosurgeons frequently care for children with traumatic scalp and skull injury. Foreign objects are often observed on imaging and may influence the clinician's decision-making process. The authors report on 2 cases of poorly visualized hair beads that had become embedded into the skull during blunt trauma. In both cases, skull radiography and CT scanning demonstrated depressed, comminuted fractures with poorly demonstrated spherical radiolucencies in the overlying scalp. The nature of these objects was initially unclear, and they could have represented air that entered the scalp during trauma. In one case, scalp inspection demonstrated no evidence of the bead. In the other case, a second bead was observed at the site of scalp laceration. In both cases, the beads were surgically removed, the fractures were elevated, and the patients recovered uneventfully. Radiolucent fashion accessories, such as hair beads, may be difficult to appreciate on clinical examination and may masquerade as clinically insignificant air following cranial trauma. If they are not removed, these foreign bodies may pose the risk of an infection. Pediatric neurosurgeons should consider hair accessories in the differential diagnosis of foreign bodies that may produce skull fracture following blunt trauma. PMID:19035690

  16. Identification of radiolucent foreign bodies in tissue using optoacoustic spectroscopic imaging

    NASA Astrophysics Data System (ADS)

    Page, Leland; Maswadi, Saher; Glickman, Randolph D.

    2011-03-01

    One of the leading causes of medical malpractice claims in emergency medicine is the misdiagnosis of the presence of foreign bodies. Radiolucent foreign bodies are especially difficult to differentiate from surrounding soft tissue, gas, and bone using existing clinical imaging modalities. Because many radiolucent foreign bodies have sufficient contrast for imaging in the optical domain, we are exploring the use of laser-induced optoacoustic imaging for the detection of foreign bodies, especially in orbital and craniofacial injuries, in which the foreign bodies are likely to lie within the penetration depth of visible and near infrared wavelengths. In order to evaluate the performance of optoacoustic imaging for clinical detection and characterization, common foreign bodies have been scanned over a range of visible and near infrared wavelengths to obtain the spectroscopic properties of the materials commonly associated with these foreign bodies. The foreign bodies are also being embedded in realistic ex vivo tissue phantoms to evaluate the changes that may occur in the spectroscopic absorption of the materials due to the interaction with tissue absorbers. Ultimately, we anticipate that spectroscopic characterization will help identify specific wavelengths to be used for imaging foreign bodies that will provide useful diagnostic data about the material properties of the object, thereby enabling the characterization, as well as the location, of the objects. This information will aid the clinician in choosing the optimal treatment course for the patient.

  17. Model-Based Comparison of Deep Brain Stimulation Array Functionality with Varying Number of Radial Electrodes and Machine Learning Feature Sets

    PubMed Central

    Teplitzky, Benjamin A.; Zitella, Laura M.; Xiao, YiZi; Johnson, Matthew D.

    2016-01-01

    electrodes minimally improved in the ability to steer, shift, and sculpt axonal activation around a DBS lead and a simple feature set consisting of the RoA center of mass and orientation enabled robust machine learning classification. These results provide important design constraints for future development of high-density DBS arrays. PMID:27375470

  18. Model-Based Comparison of Deep Brain Stimulation Array Functionality with Varying Number of Radial Electrodes and Machine Learning Feature Sets.

    PubMed

    Teplitzky, Benjamin A; Zitella, Laura M; Xiao, YiZi; Johnson, Matthew D

    2016-01-01

    electrodes minimally improved in the ability to steer, shift, and sculpt axonal activation around a DBS lead and a simple feature set consisting of the RoA center of mass and orientation enabled robust machine learning classification. These results provide important design constraints for future development of high-density DBS arrays. PMID:27375470

  19. Design, simulation and characterization of a MEMS inertia switch with flexible CNTs/Cu composite array layer between electrodes for prolonging contact time

    NASA Astrophysics Data System (ADS)

    Wang, Yang; Yang, Zhuoqing; Xu, Qiu; Chen, Wenguo; Ding, Guifu; Zhao, Xiaolin

    2015-08-01

    This paper reports an inertia switch with a flexible carbon nanotubes/copper (CNTs/Cu) composite array layer between movable and fixed electrodes, which achieves a longer contact time compared to the traditional design using rigid-to-rigid impact between electrodes. The CNTs/Cu layer is fabricated using the composite electroplating method, and the whole device is completed by multi-layer metal electroplating based on the micro-electro-mechanical systems (MEMS) process. The dynamic responses of the designed inertia switch and the contact impact between a single CNT and a fixed electrode/another CNT have both been simulated by the ANSYS finite-element-method (FEM). It is shown that the contact time of the designed inertia switch is about 100 µs under the applied 80 g half-sine-shaped acceleration in the sensing direction. Finally, the fabricated MEMS inertia switch with the flexible CNTs/Cu composite array layer between electrodes has been evaluated by a dropping hammer system. The test contact time is about112 µs, which has a good agreement with the simulation and is much longer than that of the traditional design.

  20. Effect of synthetic cannabinoids on spontaneous neuronal activity: Evaluation using Ca(2+) spiking and multi-electrode arrays.

    PubMed

    Tauskela, Joseph S; Comas, Tanya; Hewitt, Melissa; Aylsworth, Amy; Zhao, Xigeng; Martina, Marzia; Costain, Willard J

    2016-09-01

    Activation of cannabinoid receptor 1 (CB1) inhibits synaptic transmission in hippocampal neurons. The goal of this study was to evaluate the ability of benchmark and emerging synthetic cannabinoids to suppress neuronal activity in vitro using two complementary techniques, Ca(2+) spiking and multi-electrode arrays (MEAs). Neuron culture and fluorescence imaging conditions were extensively optimized to provide maximum sensitivity for detection of suppression of neural activity by cannabinoids. The neuronal Ca(2+) spiking frequency was significantly suppressed within 10min by the prototypic aminoalkylindole cannabinoid, WIN 55,212-2 (10µM). Suppression by WIN 55,212-2 was not improved by pharmacological intervention with signaling pathways known to interfere with CB1 signaling. The naphthoylindole CB1 agonist, JWH-018 suppressed Ca(2+) spiking at a lower concentration (2.5µM), and the CB1 antagonist rimonabant (5µM), reversed this suppression. In the MEA assay, the ability of synthetic CB1 agonists to suppress spontaneous electrical activity of hippocampal neurons was evaluated over 80min sessions. All benchmark (WIN 55,212-2, HU-210, CP 55,940 and JWH-018) and emerging synthetic cannabinoids (XLR-11, JWH-250, 5F-PB-22, AB-PINACA and MAM-2201) suppressed neural activity at a concentration of 10µM; furthermore, several of these compounds also significantly suppressed activity at 1µM concentrations. Rimonabant partially reversed spiking suppression of 5F-PB-22 and, to a lesser extent, of MAM-2201, supporting CB1-mediated involvement, although the inactive WIN 55,212-3 also partially suppressed activity. Taken together, synthetic cannabinoid CB1-mediated suppression of neuronal activity was detected using Ca(2+) spiking and MEAs. PMID:27262380

  1. Micro-electrode array recordings reveal reductions in both excitation and inhibition in cultured cortical neuron networks lacking Shank3.

    PubMed

    Lu, C; Chen, Q; Zhou, T; Bozic, D; Fu, Z; Pan, J Q; Feng, G

    2016-02-01

    Numerous risk genes have recently been implicated in susceptibility to autism and schizophrenia. Translating such genetic findings into disease-relevant neurobiological mechanisms is challenging due to the lack of throughput assays that can be used to assess their functions on an appropriate scale. To address this issue, we explored the feasibility of using a micro-electrode array (MEA) as a potentially scalable assay to identify the electrical network phenotypes associated with risk genes. We first characterized local and global network firing in cortical neurons with MEAs, and then developed methods to analyze the alternation between the network active period (NAP) and the network inactive period (NIP), each of which lasts tens of seconds. We then evaluated the electric phenotypes of neurons derived from Shank3 knockout (KO) mice. Cortical neurons cultured on MEAs displayed a rich repertoire of spontaneous firing, and Shank3 deletion led to reduced firing activity. Enhancing excitation with CX546 rescued the deficit in the spike rate in the Shank3 KO network. In addition, the Shank3 KO network produced a shorter NIP, and this altered network firing pattern was normalized by clonazepam, a positive modulator of the GABAA receptor. MEA recordings revealed electric phenotypes that displayed altered excitation and inhibition in the network lacking Shank3. Thus, our study highlights MEAs as an experimental framework for measuring multiple robust neurobiological end points in dynamic networks and as an assay system that could be used to identify electric phenotypes in cultured neuronal networks and to analyze additional risk genes identified in psychiatric genetics. PMID:26598066

  2. Feasibility of anomaly detection and characterization using trans-admittance mammography with 60 × 60 electrode array

    NASA Astrophysics Data System (ADS)

    Zhao, Mingkang; Wi, Hun; Lee, Eun Jung; Woo, Eung Je; In Oh, Tong

    2014-10-01

    Electrical impedance imaging has the potential to detect an early stage of breast cancer due to higher admittivity values compared with those of normal breast tissues. The tumor size and extent of axillary lymph node involvement are important parameters to evaluate the breast cancer survival rate. Additionally, the anomaly characterization is required to distinguish a malignant tumor from a benign tumor. In order to overcome the limitation of breast cancer detection using impedance measurement probes, we developed the high density trans-admittance mammography (TAM) system with 60 × 60 electrode array and produced trans-admittance maps obtained at several frequency pairs. We applied the anomaly detection algorithm to the high density TAM system for estimating the volume and position of breast tumor. We tested four different sizes of anomaly with three different conductivity contrasts at four different depths. From multifrequency trans-admittance maps, we can readily observe the transversal position and estimate its volume and depth. Specially, the depth estimated values were obtained accurately, which were independent to the size and conductivity contrast when applying the new formula using Laplacian of trans-admittance map. The volume estimation was dependent on the conductivity contrast between anomaly and background in the breast phantom. We characterized two testing anomalies using frequency difference trans-admittance data to eliminate the dependency of anomaly position and size. We confirmed the anomaly detection and characterization algorithm with the high density TAM system on bovine breast tissue. Both results showed the feasibility of detecting the size and position of anomaly and tissue characterization for screening the breast cancer.

  3. Hierarchical 3-dimensional nickel-iron nanosheet arrays on carbon fiber paper as a novel electrode for non-enzymatic glucose sensing.

    PubMed

    Kannan, Palanisamy; Maiyalagan, Thandavarayan; Marsili, Enrico; Ghosh, Srabanti; Niedziolka-Jönsson, Joanna; Jönsson-Niedziolka, Martin

    2016-01-14

    Three-dimensional nickel-iron (3-D/Ni-Fe) nanostructures are exciting candidates for various applications because they produce more reaction-active sites than 1-D and 2-D nanostructured materials and exhibit attractive optical, electrical and catalytic properties. In this work, freestanding 3-D/Ni-Fe interconnected hierarchical nanosheets, hierarchical nanospheres, and porous nanospheres are directly grown on a flexible carbon fiber paper (CFP) substrate by a single-step hydrothermal process. Among the nanostructures, 3-D/Ni-Fe interconnected hierarchical nanosheets show excellent electrochemical properties because of its high conductivity, large specific active surface area, and mesopores on its walls (vide infra). The 3-D/Ni-Fe hierarchical nanosheet array modified CFP substrate is further explored as a novel electrode for electrochemical non-enzymatic glucose sensor application. The 3-D/Ni-Fe hierarchical nanosheet arrays exhibit significant catalytic activity towards the electrochemical oxidation of glucose, as compared to the 3-D/Ni-Fe hierarchical nanospheres, and porous nanospheres. The 3-D/Ni-Fe hierarchical nanosheet arrays can access a large amount of glucose molecules on their surface (mesopore walls) for an efficient electrocatalytic oxidation process. Moreover, 3-D/Ni-Fe hierarchical nanosheet arrays showed higher sensitivity (7.90 μA μM(-1) cm(-2)) with wide linear glucose concentration ranging from 0.05 μM to 0.2 mM, and the low detection limit (LOD) of 0.031 μM (S/N = 3) is achieved by the amperometry method. Further, the 3-D/Ni-Fe hierarchical nanosheet array modified CFP electrode can be demonstrated to have excellent selectivity towards the detection of glucose in the presence of 500-fold excess of major important interferents. All these results indicate that 3-D/Ni-Fe hierarchical nanosheet arrays are promising candidates for non-enzymatic glucose sensing. PMID:26578259

  4. Co(OH)2/RGO/NiO sandwich-structured nanotube arrays with special surface and synergistic effects as high-performance positive electrodes for asymmetric supercapacitors

    NASA Astrophysics Data System (ADS)

    Xu, Han; Zhang, Chi; Zhou, Wen; Li, Gao-Ren

    2015-10-01

    High power density, high energy density and excellent cycling stability are the main requirements for high-performance supercapacitors (SCs) that will be widely used for portable consumer electronics and hybrid electric vehicles. Here we investigate novel types of hybrid Co(OH)2/reduced graphene oxide (RGO)/NiO sandwich-structured nanotube arrays (SNTAs) as positive electrodes for asymmetric supercapacitors (ASCs). The synthesized Co(OH)2/RGO/NiO SNTAs exhibit a significantly improved specific capacity (~1470 F g-1 at 5 mV s-1) and excellent cycling stability with ~98% Csp retention after 10 000 cycles because of the fast transport and short diffusion paths for electroactive species, the high utilization rate of electrode materials, and special synergistic effects among Co(OH)2, RGO, and NiO. The high-performance ASCs are assembled using Co(OH)2/RGO/NiO SNTAs as positive electrodes and active carbon (AC) as negative electrodes, and they exhibit a high energy density (115 Wh kg-1), a high power density (27.5 kW kg-1) and an excellent cycling stability (less 5% Csp loss after 10 000 cycles). This study shows an important breakthrough in the design and fabrication of multi-walled hybrid nanotube arrays as positive electrodes for ASCs.High power density, high energy density and excellent cycling stability are the main requirements for high-performance supercapacitors (SCs) that will be widely used for portable consumer electronics and hybrid electric vehicles. Here we investigate novel types of hybrid Co(OH)2/reduced graphene oxide (RGO)/NiO sandwich-structured nanotube arrays (SNTAs) as positive electrodes for asymmetric supercapacitors (ASCs). The synthesized Co(OH)2/RGO/NiO SNTAs exhibit a significantly improved specific capacity (~1470 F g-1 at 5 mV s-1) and excellent cycling stability with ~98% Csp retention after 10 000 cycles because of the fast transport and short diffusion paths for electroactive species, the high utilization rate of electrode materials, and

  5. Multiple Apical Radiolucencies and External Cervical Resorption Associated with Varicella Zoster Virus: A Case Report.

    PubMed

    Patel, Kreena; Schirru, Elia; Niazi, Sadia; Mitchell, Philip; Mannocci, Francesco

    2016-06-01

    Varicella zoster virus (VZV) is responsible for the primary infection chickenpox. After the initial infection, it remains latent but can reactivate, resulting in shingles (herpes zoster). Previous reports have implicated VZV in the pathogenesis of apical periodontitis, but the involvement of the virus has not been investigated fully. The present case describes a patient who suffered from a severe episode of shingles and subsequently developed periapical radiolucencies of all the teeth in the affected nerve distribution. Molecular and culture techniques showed the presence of VZV DNA in the root canal system in the absence of bacteria. This confirms that VZV can cause localized pulp necrosis and apical periodontitis. The lesions healed after endodontic treatment, implying chemomechanical debridement using sodium hypochlorite irrigation and a calcium hydroxide interim dressing may be effective against the virus. PMID:27133503

  6. Enhanced Sensitivity for Electrochemical Detection Using Screen-Printed Diamond Electrodes via the Random Microelectrode Array Effect.

    PubMed

    Kondo, Takeshi; Udagawa, Ikuto; Aikawa, Tatsuo; Sakamoto, Hironori; Shitanda, Isao; Hoshi, Yoshinao; Itagaki, Masayuki; Yuasa, Makoto

    2016-02-01

    The electrochemical properties of screen-printed diamond electrodes with various insulating polyester (PES) resin binder/boron-doped diamond powder (BDDP) ratios were investigated for high sensitivity electrochemical detection. For PES/BDDP weight ratios in the range of 0.3-0.5, the BDDP-printed electrodes exhibited cyclic voltammetry (CV) characteristics for Fe(CN)6(3-/4-) that are typical of a planar electrode, whereas microelectrode-like characteristics with sigmoidal CV curves were observed for PES/BDDP ratios of 1.0-2.0. Cu elemental mapping images of copper-electrodeposited BDDP-printed electrodes indicated the formation of island structures with conductive BDDP domains surrounded by an insulating PES matrix for large PES/BDDP ratios. The electrochemical detection of ascorbic acid (AA) and 8-hydroxy-2'-deoxyguanosine (8-OHdG) was also investigated using polycrystalline BDD thin-film and BDDP-printed electrodes (PES/BDDP ratio = 0.3 and 1.0). As a result, the signal-to-background (S/B) ratios for the voltammetric detection of AA and 8-OHdG were in the order BDDP-printed electrode (PES/BDDP = 1.0) > BDDP-printed electrode (PES/BDDP = 0.3) > polycrystalline BDD thin film electrode, based on the large faradaic current with respect to the background current. Therefore, the BDDP-printed electrode with a large insulating binder/BDDP ratio has the potential for use as a disposable electrode for electrochemical detection. The electrode is cheaper, lighter and more sensitive than conventional BDD electrodes. PMID:26750090

  7. Novel molecularly imprinted stir bar sorptive extraction based on an 8-electrode array for preconcentration of trace exogenous estrogens in meat.

    PubMed

    Qiao, Li; Gan, Ning; Wang, Jiayu; Gao, Huiju; Hu, Futao; Wang, Hongfei; Li, Tianhua

    2015-01-01

    A novel 8-electrode array as stir bar was designed for selective extraction of trace level exogenous estrogens from food samples, followed by liquid desorption and HPLC-photodiode array detection. The array consisted of 8 screen-printed electrodes and each electrode was modified with Fe3O4@meso-/macroporous TiO2 microspheres and molecularly imprinted film (m-TiMIF). The fabrication of the imprinted film coating was very simple without organic solvents and chemical grafting. Both bisphenol A (BPA) and diethylstilbestrol (DES) were employed as templates in m-TiMIF fabrication in order to enrich both targets simultaneously. Interestingly, the imprinted stir bar array showed higher extraction capacity and selectivity for BPA and DES than the non-imprinted counterpart. Meanwhile, it exhibited fast adsorption and desorption kinetics due to increased mass transport in the ultra-thin film. Importantly, the m-TiMIF coating was robust enough for at least 20 uses without obvious alteration in extraction performance. The main parameters affecting the extraction efficiency, including stir speeding, sample pH, ionic strength, extraction time, desorption solvent and time, were optimized. Under optimal experimental conditions, the limits of detection (S/N=3) of the developed method were 0.28 and 0.47 μg L(-1) for BPA and DES respectively, with enrichment factors of 32.6 and 52.8-fold. The linear ranges were 3.0-1500 μg L(-1) and 4.0-1500 μg L(-1) for BPA and DES, respectively. The m-TiMIF-coating conferred better recovery and selectivity, compared with the commercial stir bar coating. The new method was successfully applied to assess BPA and DES in pork and chicken samples with satisfactory recovery. PMID:25467478

  8. Review of machine learning and signal processing techniques for automated electrode selection in high-density microelectrode arrays.

    PubMed

    Van Dijck, Gert; Van Hulle, Marc M

    2014-08-01

    Recently developed CMOS-based microprobes contain hundreds of electrodes on a single shaft with interelectrode distances as small as 30 µm. So far, neuroscientists manually select a subset of those electrodes depending on their appraisal of the "usefulness" of the recorded signals, which makes the process subjective but more importantly too time consuming to be useable in practice. The ever-increasing number of recording electrodes on microelectrode probes calls for an automated selection of electrodes containing "good quality signals" or "signals of interest." This article reviews the different criteria for electrode selection as well as the basic signal processing steps to prepare the data to compute those criteria. We discuss three of them. The first two select the electrodes based on "signal quality." The first criterion computes the penalized signal-to-noise ratio (SNR); the second criterion models the neuroscientist's appraisal of signal quality. Last, our most recent work allows the selection of electrodes that capture particular anatomical cell types. The discussed algorithms perform what is called in the literature "electronic depth control" in contrast to the mechanical repositioning of the electrode shafts in search of "good quality signals" or "signals of interest." PMID:24231119

  9. Advanced LSI-based amperometric sensor array with light-shielding structure for effective removal of photocurrent and mode selectable function for individual operation of 400 electrodes.

    PubMed

    Inoue, Kumi Y; Matsudaira, Masahki; Nakano, Masanori; Ino, Kosuke; Sakamoto, Chika; Kanno, Yusuke; Kubo, Reyushi; Kunikata, Ryota; Kira, Atsushi; Suda, Atsushi; Tsurumi, Ryota; Shioya, Toshihito; Yoshida, Shinya; Muroyama, Masanori; Ishikawa, Tomohiro; Shiku, Hitoshi; Satoh, Shiro; Esashi, Masayoshi; Matsue, Tomokazu

    2015-02-01

    We have developed a large-scale integrated (LSI) complementary metal-oxide semiconductor (CMOS)-based amperometric sensor array system called "Bio-LSI" as a platform for electrochemical bio-imaging and multi-point biosensing with 400 measurement points. In this study, we newly developed a Bio-LSI chip with a light-shield structure and a mode-selectable function with the aim of extending the application range of Bio-LSI. The light shield created by the top metal layer of the LSI chip significantly reduces the noise generated by the photocurrent, whose value is less than 1% of the previous Bio-LSI without the light shield. The mode-selectable function enables the individual operation of 400 electrodes in off, electrometer, V1, and V2 mode. The off-mode cuts the electrode from the electric circuit. The electrometer-mode reads out the electrode potential. The V1-mode and the V2-mode set the selected sensor electrode at two different independent voltages and read out the current. We demonstrated the usefulness of the mode-selectable function. First, we displayed a dot picture based on the redox reactions of 2.0 mM ferrocenemethanol at 400 electrodes by applying two different independent voltages using the V1 and V2 modes. Second, we carried out a simultaneous detection of O2 and H2O2 using the V1 and V2 modes. Third, we used the off and V1 modes for the modification of the osmium-polyvinylpyridine gel polymer containing horseradish peroxidase (Os-HRP) at the selected electrodes, which act as sensors for H2O2. These results confirm that the advanced version of Bio-LSI is a promising tool that can be applied to a wide range of analytical fields. PMID:25483361

  10. Development of Micro-Electrode Array Based Tests for Neurotoxicity: Assessment of Interlaboratory Reproducibility with Neuroactive Chemicals

    PubMed Central

    Novellino, A.; Scelfo, Bibiana; Palosaari, T.; Price, A.; Sobanski, Tomasz; Shafer, T. J.; Johnstone, A. F. M.; Gross, G. W.; Gramowski, A.; Schroeder, O.; Jügelt, K.; Chiappalone, M.; Benfenati, F.; Martinoia, S.; Tedesco, M. T.; Defranchi, E.; D’Angelo, P.; Whelan, M.

    2011-01-01

    Neuronal assemblies within the nervous system produce electrical activity that can be recorded in terms of action potential patterns. Such patterns provide a sensitive endpoint to detect effects of a variety of chemical and physical perturbations. They are a function of synaptic changes and do not necessarily involve structural alterations. In vitro neuronal networks (NNs) grown on micro-electrode arrays (MEAs) respond to neuroactive substances as well as the in vivo brain. As such, they constitute a valuable tool for investigating changes in the electrophysiological activity of the neurons in response to chemical exposures. However, the reproducibility of NN responses to chemical exposure has not been systematically documented. To this purpose six independent laboratories (in Europe and in USA) evaluated the response to the same pharmacological compounds (Fluoxetine, Muscimol, and Verapamil) in primary neuronal cultures. Common standardization principles and acceptance criteria for the quality of the cultures have been established to compare the obtained results. These studies involved more than 100 experiments before the final conclusions have been drawn that MEA technology has a potential for standard in vitro neurotoxicity/neuropharmacology evaluation. The obtained results show good intra- and inter-laboratory reproducibility of the responses. The consistent inhibitory effects of the compounds were observed in all the laboratories with the 50% Inhibiting Concentrations (IC50s) ranging from: (mean ± SEM, in μM) 1.53 ± 0.17 to 5.4 ± 0.7 (n = 35) for Fluoxetine, 0.16 ± 0.03 to 0.38 ± 0.16 μM (n = 35) for Muscimol, and 2.68 ± 0.32 to 5.23 ± 1.7 (n = 32) for Verapamil. The outcome of this study indicates that the MEA approach is a robust tool leading to reproducible results. The future direction will be to extend the set of testing compounds and to propose the MEA approach as a standard screen for identification and

  11. Endogenous cholinergic tone modulates spontaneous network level neuronal activity in primary cortical cultures grown on multi-electrode arrays

    PubMed Central

    2013-01-01

    Background Cortical cultures grown long-term on multi-electrode arrays (MEAs) are frequently and extensively used as models of cortical networks in studies of neuronal firing activity, neuropharmacology, toxicology and mechanisms underlying synaptic plasticity. However, in contrast to the predominantly asynchronous neuronal firing activity exhibited by intact cortex, electrophysiological activity of mature cortical cultures is dominated by spontaneous epileptiform-like global burst events which hinders their effective use in network-level studies, particularly for neurally-controlled animat (‘artificial animal’) applications. Thus, the identification of culture features that can be exploited to produce neuronal activity more representative of that seen in vivo could increase the utility and relevance of studies that employ these preparations. Acetylcholine has a recognised neuromodulatory role affecting excitability, rhythmicity, plasticity and information flow in vivo although its endogenous production by cortical cultures and subsequent functional influence upon neuronal excitability remains unknown. Results Consequently, using MEA electrophysiological recording supported by immunohistochemical and RT-qPCR methods, we demonstrate for the first time, the presence of intrinsic cholinergic neurons and significant, endogenous cholinergic tone in cortical cultures with a characterisation of the muscarinic and nicotinic components that underlie modulation of spontaneous neuronal activity. We found that tonic muscarinic ACh receptor (mAChR) activation affects global excitability and burst event regularity in a culture age-dependent manner whilst, in contrast, tonic nicotinic ACh receptor (nAChR) activation can modulate burst duration and the proportion of spikes occurring within bursts in a spatio-temporal fashion. Conclusions We suggest that the presence of significant endogenous cholinergic tone in cortical cultures and the comparability of its modulatory effects

  12. Carbon- and Binder-Free NiCo2O4 Nanoneedle Array Electrode for Sodium-Ion Batteries: Electrochemical Performance and Insight into Sodium Storage Reaction

    NASA Astrophysics Data System (ADS)

    Lee, Jong-Won; Shin, Hyun-Sup; Lee, Chan-Woo; Jung, Kyu-Nam

    2016-02-01

    Sodium (Na)-ion batteries (NIBs) have attracted significant interest as an alternative chemistry to lithium (Li)-ion batteries for large-scale stationary energy storage systems. Discovering high-performance anode materials is a great challenge for the commercial success of NIB technology. Transition metal oxides with tailored nanoarchitectures have been considered as promising anodes for NIBs due to their high capacity. Here, we demonstrate the fabrication of a nanostructured oxide-only electrode, i.e., carbon- and binder-free NiCo2O4 nanoneedle array (NCO-NNA), and its feasibility as an anode for NIBs. Furthermore, we provide an in-depth experimental study of the Na storage reaction (sodiation and desodiation) in NCO-NNA. The NCO-NNA electrode is fabricated on a conducting substrate by a hydrothermal method with subsequent heat treatment. When tested in an electrochemical Na half-cell, the NCO-NNA electrode exhibits excellent Na storage capability: a charge capacity as high as 400 mAh g-1 is achieved at a current density of 50 mA g-1. It also shows a greatly improved cycle life (~215 mAh g-1 after 50 cycles) in comparison to a conventional powder-type electrode (~30 mAh g-1). However, the Na storage performance is still inferior to that of Li, which is mainly due to sluggish kinetics of sodiation-desodiation accompanied by severe volume change.

  13. Long term in vitro functional stability and recording longevity of fully integrated wireless neural interfaces based on the Utah Slant Electrode Array.

    PubMed

    Sharma, Asha; Rieth, Loren; Tathireddy, Prashant; Harrison, Reid; Oppermann, Hermann; Klein, Matthias; Töpper, Michael; Jung, Erik; Normann, Richard; Clark, Gregory; Solzbacher, Florian

    2011-08-01

    We evaluate the encapsulation and packaging reliability of a fully integrated wireless neural interface based on a Utah Slant Electrode Array/integrated neural interface-recording version 5 (USEA/INI-R5) system by monitoring the long term in vitro functional stability and recording longevity. The INI encapsulated with 6 µm Parylene-C was immersed in phosphate buffered saline (PBS) for a period of over 276 days (with the monitoring of the functional device still ongoing). The full functionality (wireless radio-frequency power, command and signal transmission) and the ability of the electrodes to record artificial neural signals even after 276 days of PBS soaking with little change (within 14%) in signal/noise amplitude constitute a major milestone in long term stability and allow us to study and evaluate the encapsulation reliability, functional stability and its potential usefulness for a wireless neural interface for future chronic implants. PMID:21775785

  14. Single-pulse driven, large-aperture 2×1 array plasma-electrodes optical switch for SG-II upgrading facility

    NASA Astrophysics Data System (ADS)

    Zhang, Jun; Wu, Dengsheng; Zheng, Jiangang; Zheng, Kuixing; Zhu, Qihua; Zhang, Xiongjun

    2014-12-01

    We demonstrate the design and performance of an optical switch that has been constructed for the SG-II upgrading facility. The device is a longitudinal, potassium di-hydrogen phosphate (KDP), 360 mm×360 mm aperture, and 2×1 array electro-optical switch driven by a 20 kV output switching-voltage pulse generator through two plasma electrodes produced at the rise edge of the switching-voltage pulse. The results show that the temporal responses and the spatial performance of the optical switch fulfill the operation requirements of the SG-II upgrading facility.

  15. Comprehensive Chronic Laminar Single-Unit, Multi-Unit, and Local Field Potential Recording Performance With Planar Single Shank Electrode Arrays

    PubMed Central

    Kozai, Takashi D. Y.; Du, Zhanhong; Gugel, Zhannetta V.; Smith, Matthew A.; Chase, Steven M.; Bodily, Lance M; Caparosa, Ellen M.; Friedlander, Robert M.; Cui, X. Tracy

    2015-01-01

    Background Intracortical electrode arrays that can record extracellular action potentials from small, targeted groups of neurons are critical for basic neuroscience research and emerging clinical applications. In general, these electrode devices suffer from reliability and variability issues, which have led to comparative studies of existing and emerging electrode designs to optimize performance. Comparisons of different chronic recording devices have been limited to single-unit (SU) activity and employed a bulk averaging approach treating brain architecture as homogeneous with respect to electrode distribution. New Method In this study, we optimize the methods and parameters to quantify evoked multi-unit (MU) and local field potential (LFP) recordings in 8 mice visual cortices. Results These findings quantify the large recording differences stemming from anatomical differences in depth and the layer dependent relative changes to SU and MU recording performance over 6-months. For example, performance metrics in Layer V and stratum pyramidale were initially higher than Layer II/III, but decrease more rapidly. On the other hand, Layer II/III maintained recording metrics longer. In addition, chronic changes at the level of layer IV are evaluated using visually evoked current source density. Comparison with Existing Method(s) The use of MU and LFP activity for evaluation and tracking biological depth provides a more comprehensive characterization of the electrophysiological performance landscape of microelectrodes. Conclusions A more extensive spatial and temporal insight into the chronic electrophysiological performance over time will help uncover the biological and mechanical failure mechanisms of the neural electrodes and direct future research toward the elucidation of design optimization for specific applications. PMID:25542351

  16. Conveniently fabricated heterojunction ZnO/TiO2 electrodes using TiO2 nanotube arrays for dye-sensitized solar cells

    NASA Astrophysics Data System (ADS)

    Liu, Rui; Yang, Wein-Duo; Qiang, Liang-Sheng; Liu, Hsin-Yi

    2012-12-01

    TiO2 nanotube arrays with an inner average pore diameter of 83 nm and a length of 14 μm are grown on Ti foils by electrochemical anodization in ammonium fluoride-water-glycerol solution. ZnO is introduced into the TiO2 nanotube arrays by a convenient electrodeposition technique. ZnO/TiO2 nanocomposites supported on Ti substrate are used as the photo-anode electrode for dye-sensitized solar cells (DSSCs). The morphology, structure and electrochemical properties are investigated using field-emission scanning electron microscopy, transmission electron microscopy, X-ray diffraction, UV-vis diffusion reflection spectroscopy, X-ray photoelectron spectroscopy and cyclic voltammetry measurements. It is found that ZnO have been embedded in the TiO2 nanotube arrays, and changed some photoelectric properties. The conversion efficiency of the dye-sensitized solar cells is more than doubled, compared with that of bare TiO2 nanotube arrays with deposited 60 min. This improvement comes from the synergetic effect between ZnO and TiO2, which increases dye absorption, electron transport and electron lifetime.

  17. Ni foam supported three-dimensional vertically aligned and networked layered CoO nanosheet/graphene hybrid array as a high-performance oxygen evolution electrode

    NASA Astrophysics Data System (ADS)

    Yuan, Weiyong; Zhao, Ming; Yuan, Jia; Li, Chang Ming

    2016-07-01

    The sluggish oxygen evolution reaction (OER) represents a major kinetic bottleneck in water splitting. Herein we report the synthesis of a novel Ni foam (NF) supported 3-D vertically aligned and interconnected layered CoO nanosheet array with controlled density, layer thickness, and interlayer spacing, and the conformal self-assembly of graphene on this nanosheet array. The obtained CoO layered nanosheet/graphene hybrid nanoarray was directly used as an OER electrode, showing a current density of 10 mA cm-2 at an overpotential of 330 mV and a Tafel slope of 79 mV dec-1, both of which are much lower than pristine NF and the nanosheet array without graphene, and are among the lowest reported for Co-based OER catalysts and transition metal oxide-based ones measured under the same conditions. In addition, it can retain 92.4% of the current density after 66 h of chronoamperometry testing at a potential of 1.0 V vs. SCE, and 94.3% of the current density at 1.0 V vs. SCE after 200 cyclic voltammetry cycles (0-1.0 V vs. SCE). The excellent catalytic activity and stability toward OER are ascribed to the 3-D NF supported robustly grown networked layered nanosheet array structure and the synergistic effects between CoO layered nanosheets and graphene.

  18. Effects of dose reduction on the detectability of standardized radiolucent lesions in digital panoramic radiography.

    PubMed

    Dula, K; Sanderink, G; van der Stelt, P F; Mini, R; Buser, D

    1998-08-01

    Dose reduction in digital panoramic radiography was studied. Intentional underexposure was performed with the Orthophos DS while six different human mandibles were radiographed. Exposure settings were 69 kV/15 mA (standard), 64 kV/16 mA, and 60 kV/16 mA. Standardized spherical defects, each either 1 or 1.25 mm in diameter, were simulated in 288 of 432 images, and seven observers decided whether defects were present or not. Areas under the receiver operating characteristics curves were calculated. They showed no significant differences in the detectability of the 1-mm defect at 69, 64, or 60 kV. For the 1.25-mm defect, no difference was found between the 69 and 60 kV images, but a statistically significant different detectability was found for 64 kV images in comparison with both 69 and 60 kV images. A dose reduction of up to 43% was ascertained with a Pedo-RT-Humanoid phantom when panoramic radiography was performed at 60 kV/16 mA. The conclusion is that with the Orthophos DS, it seems possible to reduce the dose rate of x-rays without loss of diagnostic quality in the case of radiolucent changes. PMID:9720100

  19. Multilayer TiO2 nanorod cloth/nanorod array electrode for dye-sensitized solar cells and self-powered UV detectors.

    PubMed

    Wang, Zhuoran; Ran, Sihan; Liu, Bin; Chen, Di; Shen, Guozhen

    2012-06-01

    A multilayer TiO(2) nanorod-assembled cloth/nanorod array based electrode was fabricated by transferring different layers of TiO(2) nanorod-assembled cloth (TNRC) onto nanorod array grown on the conducting FTO substrate (titania nanorod, TNR). Combining the superior electron transport characteristics of TNR and outstanding optical properties of TNRC, the nanostructured electrode composed of two layers of TNRC meets the optimized design for high quality dye-sensitized solar cells (DSCs) and self-powered UV detectors. The highest efficiency of 4.02% for DSC under AM 1.5 was achieved with a high short circuit current density of 9.81 mA cm(-2), which was proved to be owing to the enhanced dye anchoring, light scattering and reduced charge recombination. For the photoelectrochemical (PEC) UV detector, the highest quantum efficiency of over 46% was obtained and a high photocurrent response of 0.271 mA cm(-2) was observed, together with the excellent self-powered, fast response and "visible blind" characteristics. A perfect linear response to the changed low-power signal indicates great potential for practical applications. PMID:22549639

  20. Study of Interdigitated Electrode Arrays Using Experiments and Finite Element Models for the Evaluation of Sterilization Processes

    PubMed Central

    Oberländer, Jan; Jildeh, Zaid B.; Kirchner, Patrick; Wendeler, Luisa; Bromm, Alexander; Iken, Heiko; Wagner, Patrick; Keusgen, Michael; Schöning, Michael J.

    2015-01-01

    In this work, a sensor to evaluate sterilization processes with hydrogen peroxide vapor has been characterized. Experimental, analytical and numerical methods were applied to evaluate and study the sensor behavior. The sensor set-up is based on planar interdigitated electrodes. The interdigitated electrode structure consists of 614 electrode fingers spanning over a total sensing area of 20 mm2. Sensor measurements were conducted with and without microbiological spores as well as after an industrial sterilization protocol. The measurements were verified using an analytical expression based on a first-order elliptical integral. A model based on the finite element method with periodic boundary conditions in two dimensions was developed and utilized to validate the experimental findings. PMID:26473883

  1. Study of interdigitated electrode arrays using experiments and finite element models for the evaluation of sterilization processes.

    PubMed

    Oberländer, Jan; Jildeh, Zaid B; Kirchner, Patrick; Wendeler, Luisa; Bromm, Alexander; Iken, Heiko; Wagner, Patrick; Keusgen, Michael; Schöning, Michael J

    2015-01-01

    In this work, a sensor to evaluate sterilization processes with hydrogen peroxide vapor has been characterized. Experimental, analytical and numerical methods were applied to evaluate and study the sensor behavior. The sensor set-up is based on planar interdigitated electrodes. The interdigitated electrode structure consists of 614 electrode fingers spanning over a total sensing area of 20 mm². Sensor measurements were conducted with and without microbiological spores as well as after an industrial sterilization protocol. The measurements were verified using an analytical expression based on a first-order elliptical integral. A model based on the finite element method with periodic boundary conditions in two dimensions was developed and utilized to validate the experimental findings. PMID:26473883

  2. Freestanding one-dimensional manganese dioxide nanoflakes-titanium cabide/carbon core/double shell arrays as ultra-high performance supercapacitor electrode

    NASA Astrophysics Data System (ADS)

    Kong, Shuying; Cheng, Kui; Ouyang, Tian; Ye, Ke; Gao, Yinyi; Wang, Guiling; Cao, Dianxue

    2015-10-01

    In this paper, freestanding one-dimensional MnO2 nanoflakes are successful prepared through a simple hydrothermal reaction by using the carbon shell of TiC/C core/shell arrays as the sacrificial template. Its structure and morphology are characterized by X-ray diffractometer, X-ray photoelectron spectroscopy, Raman spectroscopy, scanning electron microscopy, energy dispersive X-ray spectrometer and transmission electron microscopy. Results show that the thickness of the carbon shell decreased but also remained and the ultrathin MnO2 nanoflakes with thickness less than 5 nm uniformly grow on the surfaces of the TiC/C nanowire to form a core/double shell structure after the hydrothermal reaction. The electrochemical performance of the as-prepared electrode is evaluated by cyclic voltammetrys, galvanostatic charging-discharging tests and electrochemical impedance spectroscopy, and high capacities, excellent rate capabilities and exemplary cycling performance is obtained. The as-prepared electrode shows a high specific capacitance of 598.8 F g-1 and 85.8% of its initial capacitance is retained after 10,000 cycles at a high discharge current density of 10 A g-1, suggesting that this structure has a promising future as high-performance supercapacitor electrode.

  3. Improved electrochemical performances of binder-free CoMoO4 nanoplate arrays@Ni foam electrode using redox additive electrolyte

    NASA Astrophysics Data System (ADS)

    Veerasubramani, Ganesh Kumar; Krishnamoorthy, Karthikeyan; Kim, Sang Jae

    2016-02-01

    Herein, we are successfully prepared cobalt molybdate (CoMoO4) grown on nickel foam as a binder free electrode by hydrothermal approach for supercapacitors and improved their electrochemical performances using potassium ferricyanide (K3Fe(CN)6) as redox additive. The formation of CoMoO4 on Ni foam with high crystallinity is confirmed using XRD, Raman, and XPS measurements. The nanoplate arrays (NPAs) of CoMoO4 are uniformly grown on Ni foam which is confirmed by FE-SEM analysis. The prepared binder-free CoMoO4 NPAs achieved maximum areal capacity of 227 μAh cm-2 with KOH electrolyte at 2.5 mA cm-2. This achieved areal capacity is further improved about three times using the addition of K3Fe(CN)6 as redox additive. The increased electrochemical performances of CoMoO4 NPAs on Ni foam electrode via redox additive are discussed in detail and the mechanism has been explored. Moreover, the assembled CoMoO4 NPAs on Ni foam//activated carbon asymmetric supercapacitor device with an extended operating voltage window of 1.5 V exhibits an excellent performances such as high energy density and cyclic stability. The overall performances of binder-free CoMoO4 NPAs on Ni foam with redox additives suggesting their potential use as positive electrode material for high performance supercapacitors.

  4. Unique Core-Shell Nanorod Arrays with Polyaniline Deposited into Mesoporous NiCo2O4 Support for High-Performance Supercapacitor Electrodes.

    PubMed

    Jabeen, Nawishta; Xia, Qiuying; Yang, Mei; Xia, Hui

    2016-03-01

    Polyaniline (PANI), one of the most attractive conducting polymers for supercapacitors, demonstrates a great potential as high performance pseudocapacitor materials. However, the poor cycle life owing to structural instability remains as the major hurdle for its practical application; hence, making the structure-to-performance design on the PANI-based supercapacitors is highly desirable. In this work, unique core-shell NiCo2O4@PANI nanorod arrays (NRAs) are rationally designed and employed as the electrode material for supercapacitors. With highly porous NiCo2O4 as the conductive core and strain buffer support and nanoscale PANI layer as the electrochemically active component, such a heterostructure achieves favorably high capacitance while maintaining good cycling stability and rate capability. By adopting the optimally uniform and intimate coating of PANI, the fabricated electrode exhibits a high specific capacitance of 901 F g(-1) at 1 A g(-1) in 1 M H2SO4 electrolyte and outstanding capacitance retention of ∼91% after 3000 cycles at a high current density of 10 A g(-1), which is superior to the electrochemical performance of most reported PANI-based pseudocapacitors in literature. The enhanced electrochemical performance demonstrates the complementary contributions of both componential structures in the hybrid electrode design. Also, this work propels a new direction of utilizing porous matrix as the highly effective support for polymers toward efficient energy storage. PMID:26889785

  5. Electrochemically assisted photocatalytic degradation of 4-chlorophenol by ZnFe2O4-modified TiO2 nanotube array electrode under visible light irradiation.

    PubMed

    Hou, Yang; Li, Xinyong; Zhao, Qidong; Quan, Xie; Chen, Guohua

    2010-07-01

    A well-aligned ZnFe(2)O(4)/TiO(2) composite nanotube array (ZnFe(2)O(4)/TiO(2)-NTs) electrode with visible-light activity was successfully prepared using a two-step electrochemical process of anodization and a novel cathodic electrodeposition method followed by annealing. The ZnFe(2)O(4) nanoparticles were highly dispersed inside the TiO(2)-NTs but minimized at the tube entrances. The structure and optical properties of the TiO(2) nanotubes and the derived composites have been well characterized. The composites displayed a strong photo response in the visible region and low recombination rate of the electron-hole pairs. In addition, the synthesized ZnFe(2)O(4)/TiO(2)-NTs electrode showed much higher photocurrent density in the visible region than pure TiO(2)-NTs electrode. The dramatically enhanced electrochemically assisted photocatalytic activity of the composite electrode was evaluated in the decomposition of 4-chlorophenol and dichloroacetate under visible light irradiation (420 nm < lambda < 600 nm). The improved photoelectrocatalytic (PEC) activity is derived from the synergetic effect between ZnFe(2)O(4) and TiO(2), which promoted the migration efficiency of photogenerated carriers at the interface of the composite and enhanced the efficiency of photon harvesting in the visible region. The degradation of 4-chlorophenol was monitored by measuring Cl(-) concentrations and analyzing reaction intermediates by high-performance liquid chromatography-mass spectroscopy (HPLC-MS). PMID:20527761

  6. Carbon- and Binder-Free NiCo2O4 Nanoneedle Array Electrode for Sodium-Ion Batteries: Electrochemical Performance and Insight into Sodium Storage Reaction.

    PubMed

    Lee, Jong-Won; Shin, Hyun-Sup; Lee, Chan-Woo; Jung, Kyu-Nam

    2016-12-01

    Sodium (Na)-ion batteries (NIBs) have attracted significant interest as an alternative chemistry to lithium (Li)-ion batteries for large-scale stationary energy storage systems. Discovering high-performance anode materials is a great challenge for the commercial success of NIB technology. Transition metal oxides with tailored nanoarchitectures have been considered as promising anodes for NIBs due to their high capacity. Here, we demonstrate the fabrication of a nanostructured oxide-only electrode, i.e., carbon- and binder-free NiCo2O4 nanoneedle array (NCO-NNA), and its feasibility as an anode for NIBs. Furthermore, we provide an in-depth experimental study of the Na storage reaction (sodiation and desodiation) in NCO-NNA. The NCO-NNA electrode is fabricated on a conducting substrate by a hydrothermal method with subsequent heat treatment. When tested in an electrochemical Na half-cell, the NCO-NNA electrode exhibits excellent Na storage capability: a charge capacity as high as 400 mAh g(-1) is achieved at a current density of 50 mA g(-1). It also shows a greatly improved cycle life (~215 mAh g(-1) after 50 cycles) in comparison to a conventional powder-type electrode (~30 mAh g(-1)). However, the Na storage performance is still inferior to that of Li, which is mainly due to sluggish kinetics of sodiation-desodiation accompanied by severe volume change. PMID:26831683

  7. Sputtered highly ordered TiO2 nanorod arrays and their applications as the electrode in dye-sensitized solar cells.

    PubMed

    Meng, Lijian; Ma, Aifeng; Ying, Pinliang; Feng, Zhaochi; Li, Can

    2011-02-01

    For the first time, the TiO2 nanorod arrays have been prepared on ITO substrates at room temperature by dc reactive magnetron sputtering technique. These TiO2 nanorods have a preferred orientation along the (220) direction and are perpendicular to the ITO substrate. Both the X-ray diffraction and Raman scattering measurements show that the highly ordered TiO2 nanorod arrays have an anatase crystal structure. The diameter of the nanorod varies from 30 nm to 100 nm and the nanorod length can be varied from several hundred nanometers to several micrometers depending on the deposition time. The TiO2 nanorod arrays with about 3 micrometers length have been used as an electrode for dye-sensitized solar cell (DSSC). Short-circuit photocurrent density, open-circuit voltage, fill factor and light-to-electricity conversion efficiency at 100 mW/cm2 light intensity are estimated to be 12.76 mA/cm2, 0.65 V, 0.63 and 5.25%, respectively, for the DSSC made of the TiO2 nanorods. PMID:21456121

  8. Hierarchical 3-dimensional nickel-iron nanosheet arrays on carbon fiber paper as a novel electrode for non-enzymatic glucose sensing

    NASA Astrophysics Data System (ADS)

    Kannan, Palanisamy; Maiyalagan, Thandavarayan; Marsili, Enrico; Ghosh, Srabanti; Niedziolka-Jönsson, Joanna; Jönsson-Niedziolka, Martin

    2015-12-01

    Three-dimensional nickel-iron (3-D/Ni-Fe) nanostructures are exciting candidates for various applications because they produce more reaction-active sites than 1-D and 2-D nanostructured materials and exhibit attractive optical, electrical and catalytic properties. In this work, freestanding 3-D/Ni-Fe interconnected hierarchical nanosheets, hierarchical nanospheres, and porous nanospheres are directly grown on a flexible carbon fiber paper (CFP) substrate by a single-step hydrothermal process. Among the nanostructures, 3-D/Ni-Fe interconnected hierarchical nanosheets show excellent electrochemical properties because of its high conductivity, large specific active surface area, and mesopores on its walls (vide infra). The 3-D/Ni-Fe hierarchical nanosheet array modified CFP substrate is further explored as a novel electrode for electrochemical non-enzymatic glucose sensor application. The 3-D/Ni-Fe hierarchical nanosheet arrays exhibit significant catalytic activity towards the electrochemical oxidation of glucose, as compared to the 3-D/Ni-Fe hierarchical nanospheres, and porous nanospheres. The 3-D/Ni-Fe hierarchical nanosheet arrays can access a large amount of glucose molecules on their surface (mesopore walls) for an efficient electrocatalytic oxidation process. Moreover, 3-D/Ni-Fe hierarchical nanosheet arrays showed higher sensitivity (7.90 μA μM-1 cm-2) with wide linear glucose concentration ranging from 0.05 μM to 0.2 mM, and the low detection limit (LOD) of 0.031 μM (S/N = 3) is achieved by the amperometry method. Further, the 3-D/Ni-Fe hierarchical nanosheet array modified CFP electrode can be demonstrated to have excellent selectivity towards the detection of glucose in the presence of 500-fold excess of major important interferents. All these results indicate that 3-D/Ni-Fe hierarchical nanosheet arrays are promising candidates for non-enzymatic glucose sensing.Three-dimensional nickel-iron (3-D/Ni-Fe) nanostructures are exciting candidates for

  9. Evaluation of juxta-apical radiolucency in cone beam CT images

    PubMed Central

    Harada, N; Araki, K; Sano, T; Goto, T K

    2014-01-01

    Objectives: The aim of this study was to analyse the position and relationship of juxta-apical radiolucency (JAR) to the mandibular canal and buccal and/or lingual cortical plates using cone beam CT (CBCT). Methods: A retrospective study was carried out to analyse the JAR on CBCT for 27 patients. These findings were compared with 27 age- and sex-matched patients without the presence of JAR, which acted as the control group. The CBCT images were analysed according to a checklist, to evaluate the position of the JAR and its relationship to the mandibular canal. Then, any thinning or perforation of either the buccal or lingual cortical plate due to JAR was noted, and a classification to quantify the thinning of cortical plates was proposed. The findings in the two groups were analysed using a paired comparison by McNemar test. Results: A statistical increased thinning of cortical plates was seen in the JAR group compared with the control group, and most of the cases were in the J3 group. None of the patients in either the JAR or the control group showed perforation of the buccal and/or lingual cortical plate on CBCT images. Conclusions: A classification to quantify the thinning of cortical plates was proposed, which may be used for objective evaluation of the thinning of the cortical plates in future studies. The present study gives an insight into the relationship of the juxta-apical area with the mandibular canal and cortical plates in the mandible using CBCT. PMID:24694213

  10. Evaluation of adhesive-free crossed-electrode poly(vinylidene fluoride) copolymer array transducers for high frequency imaging

    NASA Astrophysics Data System (ADS)

    Wagle, Sanat; Decharat, Adit; Habib, Anowarul; Ahluwalia, Balpreet S.; Melandsø, Frank

    2016-07-01

    High frequency crossed-electrode transducers have been investigated, both as single and dual layer transducers. Prototypes of these transducers were developed for 4 crossed lines (yielding 16 square elements) on a polymer substrate, using a layer-by-layer deposition method for poly(vinylidene fluoride–trifluoroethylene) [P(VDF–TrFE)] with intermediate sputtered electrodes. The transducer was characterized using various methods [LCR analyzer, a pulse–echo experimental setup, and a numerical Finite element method (FEM) model] and evaluated in terms of uniformity of bandwidth and acoustical energy output. All 16 transducer elements produced broad-banded ultrasonic spectra with small variation in central frequency and ‑6 dB bandwidth. The frequency responses obtained experimentally were verified using a numerical model.

  11. Ultramicroband array electrode. 1. Analysis of mercury in contaminated soils and flue gas exposed samples using a gold-plated iridium portable system by anodic stripping voltammetry

    SciTech Connect

    Xiao, L.; Dietze, W.; Nyasulu, F.; Mibeck, B.A.F.

    2006-07-15

    The applicability of a gold-plated iridium Nano-Band array ultramicroelectrode (6 {mu}m by 0.2 {mu}m, 64-{mu}m interspacing, 100 electrode bands) in the analysis of mercury using a portable system is demonstrated by anodic stripping voltammetry in real-life samples. Optimized measurement parameters, 0.1 M HCl electrolyte, plating potential of 0 mV, and staircase scan mode were identified. The dynamic linear range is 10-180 ppb at 5-s deposition time with 1.5 {mu}C of gold plated. The experimental detection limit for Hg{sup 2+} in 0.1 M HCl was 0.5 ppb at a deposition time of 4 min and a scan rate of 10 V/s. Real-life samples, such as flue gas exposed samples from flue gas simulators could be analyzed within 5 min using the method of standard additions. We identified a field-portable extraction procedure for soil samples using 1:1 concentrated HNO{sub 3}/30% H{sub 2}O{sub 2} mixture, compatible with ASV and the iridium electrode. The detection limit for soils is 1 ppm. The results obtained using ASV are in good agreement with reference values using cold vapor atomic absorption for the sample matrixes studied here. To our knowledge, this is the first mercury application using a reusable iridium array ultramicroelectrode. The portable potentiostat is less than 500 g, and together with the portable digestion method, makes the Nano-Band Explorer system field applicable.

  12. Evaluation of the packaging and encapsulation reliability in fully integrated, fully wireless 100 channel Utah Slant Electrode Array (USEA): Implications for long term functionality

    PubMed Central

    Sharma, A.; Rieth, L.; Tathireddy, P.; Harrison, R.; Oppermann, H.; Klein, M.; Töpper, M.; Jung, E.; Normann, R.; Clark, G.; Solzbacher, F.

    2011-01-01

    The encapsulation and packaging reliability in fully integrated, fully wireless 100 channel Utah Slant Electrode Array (USEA)/integrated neural interface-recording version 5 (INI-R5) has been evaluated by monitoring the extended long term in-vitro functional stability and recording longevity. The INI encapsulated with 6-μm Parylene-C was immersed in phosphate buffer saline (PBS) at room temperature for a period of over 12 months. The USEA/INI-R5, while being soaked was powered and configured wirelessly through 2.765 MHz inductive link and the transmitted frequency shift keying (FSK) modulated radio-frequency (RF) (900 MHz Industrial, scientific, medical-ISM band) signal was also recorded wirelessly as a function of soak time. In order to test the long term recording ability, in-vitro wireless recording was performed in agarose for few channels. The full functionality and the ability of the electrodes to record artificial neural signals even after 12 months of PBS soak provides a measure of encapsulation reliability, the functional and recording stability in fully integrated wireless neural interface and potential usefulness for future chronic implants. PMID:23288983

  13. Determination of four water-soluble compounds in Salvia miltiorrhiza Bunge by high-performance liquid chromatography with a coulometric electrode array system.

    PubMed

    Ma, Lijuan; Zhang, Xuezhu; Guo, Hui; Gan, Yiru

    2006-04-01

    A method has been developed to determine the four water-soluble components-Danshensu (I), protocatechuic acid (II), protocatechuic aldehyde (III) and salvianolic acid B (IV) in Chinese medicine plant Salvia miltiorrhiza Bunge using high-performance liquid chromatography with a coulometric electrode array detection (HPLC-CEAD) system. Heat reflux extraction was used to pretreat the sample. This analysis was carried on a column of Hypersil C18 (250 mm x 4.6 mm, 5 microm) with a mobile phase of sodium acetate (pH 2.5, 50 mM) and acetonitrile in gradient mode. An ESA electrochemical detector monitored the four compounds. Potentials of four electrodes in series were set at 100, 150, 200 and 250 mV, respectively. Optimization of the pH of mobile phase and the proportion of acetonitrile were also performed. Calibration curve showed good linearity with correlation coefficients (r) more than 0.9937. Average recoveries of the four compounds were more than 92% and relative standard deviations were less than 6.6%. This method appeared to be stable, sensitive and reproducible for determination of the four water-soluble compounds in Chinese medicine plant S. miltiorrhiza Bunge. PMID:16500160

  14. Spatio-temporal mapping of variation potentials in leaves of Helianthus annuus L. seedlings in situ using multi-electrode array.

    PubMed

    Zhao, Dong-Jie; Wang, Zhong-Yi; Huang, Lan; Jia, Yong-Peng; Leng, John Q

    2014-01-01

    Damaging thermal stimuli trigger long-lasting variation potentials (VPs) in higher plants. Owing to limitations in conventional plant electrophysiological recording techniques, recorded signals are composed of signals originating from all of the cells that are connected to an electrode. This limitation does not enable detailed spatio-temporal distributions of transmission and electrical activities in plants to be visualised. Multi-electrode array (MEA) enables the recording and imaging of dynamic spatio-temporal electrical activities in higher plants. Here, we used an 8 × 8 MEA with a polar distance of 450 μm to measure electrical activities from numerous cells simultaneously. The mapping of the data that were recorded from the MEA revealed the transfer mode of the thermally induced VPs in the leaves of Helianthus annuus L. seedlings in situ. These results suggest that MEA can enable recordings with high spatio-temporal resolution that facilitate the determination of the bioelectrical response mode of higher plants under stress. PMID:24961469

  15. TiO2 nanotube array photoelectrocatalyst and Ni-Sb-SnO2 electrocatalyst bifacial electrodes: a new type of bifunctional hybrid platform for water treatment.

    PubMed

    Yang, So Young; Choi, Wonyong; Park, Hyunwoong

    2015-01-28

    Bifunctional hybrid electrodes capable of generating various reactive oxygen species (ROS) over a wide range of potentials were developed by coupling electrocatalysts and photoelectrocatalysts. To achieve this, Ni-doped Sb-SnO2 (NSS) was deposited on one side of a titanium (Ti) foil while the other side was anodized to grow a TiO2 nanotube array (TNA) for electrochemical ozone generation and photoelectrochemical hydroxyl radical generation, respectively. Surface characterization indicated that NSS and TNA were formed and spatially separated yet electrically connected through the Ti substrate. While each catalyst possessed unique electrochemical properties, the coupling of both catalysts resulted in mixed electrochemical properties that drove electrocatalysis at high potentials and photoelectrocatalysis at low potentials. The performance of the NSS/TNA electrode for phenol decomposition was ∼3 times greater than that of single-layer catalysts and ∼1.5 times greater than the combined catalytic performances of the individual NSS and TNA catalysts. This synergistic effect was attributed partly to the simultaneous generation of hydroxyl radicals and ozone, followed by the production of other ROS. A mechanism for the generation of ROS was discussed. PMID:25561436

  16. A Wireless and Batteryless Microsystem with Implantable Grid Electrode/3-Dimensional Probe Array for ECoG and Extracellular Neural Recording in Rats

    PubMed Central

    Chang, Chih-Wei; Chiou, Jin-Chern

    2013-01-01

    This paper presents the design and implementation of an integrated wireless microsystem platform that provides the possibility to support versatile implantable neural sensing devices in free laboratory rats. Inductive coupled coils with low dropout regulator design allows true long-term recording without limitation of battery capacity. A 16-channel analog front end chip located on the headstage is designed for high channel account neural signal conditioning with low current consumption and noise. Two types of implantable electrodes including grid electrode and 3D probe array are also presented for brain surface recording and 3D biopotential acquisition in the implanted target volume of tissue. The overall system consumes less than 20 mA with small form factor, 3.9 × 3.9 cm2 mainboard and 1.8 × 3.4 cm2 headstage, is packaged into a backpack for rats. Practical in vivo recordings including auditory response, brain resection tissue and PZT-induced seizures recording demonstrate the correct function of the proposed microsystem. Presented achievements addressed the aforementioned properties by combining MEMS neural sensors, low-power circuit designs and commercial chips into system-level integration. PMID:23567528

  17. Atmospheric air diffuse array-needles dielectric barrier discharge excited by positive, negative, and bipolar nanosecond pulses in large electrode gap

    NASA Astrophysics Data System (ADS)

    Zhang, Li; Yang, De-zheng; Wang, Wen-chun; Liu, Zhi-jie; Wang, Sen; Jiang, Peng-chao; Zhang, Shuai

    2014-09-01

    In this paper, positive, negative, and bipolar nanosecond pulses are employed to generate stable and diffuse discharge plasma using array needles-plate electrode configuration at atmospheric pressure. A comparison study of discharge images, electrical characteristics, optical emission spectra, and plasma vibrational temperature and rotational temperatures in three pulsed polarity discharges is carried on under different discharge conditions. It is found that bipolar pulse is beneficial to the excitation of diffuse dielectric barrier discharge, which can generate a room temperature plasma with more homogeneous and higher discharge intensity compared with unipolar discharges. Under the condition of 6 mm electrode gap distance, 26 kV pulse peak voltage, and 150 Hz pulse repetition rate, the emission intensity of N2 (C3Πu → B3Πg) of the bipolar pulsed discharge is 4 times higher than the unipolar discharge (both positive and negative), while the plasma gas temperature is kept at 300 K, which is about 10-20 K lower than the unipolar discharge plasma.

  18. Boosting the Open Circuit Voltage and Fill Factor of QDSSCs Using Hierarchically Assembled ITO@Cu2S Nanowire Array Counter Electrodes.

    PubMed

    Jiang, Yan; Yu, Bin-Bin; Liu, Jie; Li, Zhi-Hua; Sun, Jian-Kun; Zhong, Xin-Hua; Hu, Jin-Song; Song, Wei-Guo; Wan, Li-Jun

    2015-05-13

    The key challenges in enhancing the power conversion efficiency (PCE) of a quantum dot-sensitized solar cell (QDSSC) are efficiently achieving charge separation at the photoanode and improving the charge transfer, which is limited by the interface between the electrolyte and the counter electrode (CE). Here, hierarchically assembled ITO@Cu2S nanowire arrays with conductive single-crystalline ITO cores and Cu2S nanocrystal shells were designed as efficient QDSSCs CEs. These arrays not only provided an efficient three-dimensional charge transport network but also allowed for the effective deposition of more Cu2S nanocrystals as active sites to catalyze the electrolyte reaction. This design considerably reduced the sheet and charge transfer resistance of the CE, thus decreasing the series resistance and increasing the shunt resistance of the QDSSC. As a result, QDSSCs with this CE exhibited an unprecedentedly high Voc of 0.688 V, a fill factor of 58.39%, and a PCE of 6.12%, which is 21.2% higher than that of the conventional brass/Cu2S CE. PMID:25929671

  19. Fabrication of electrodes with ultralow platinum loading by RF plasma processing of self-assembled arrays of Au@Pt nanoparticles

    NASA Astrophysics Data System (ADS)

    Banerjee, Ipshita; Kumaran, V.; Santhanam, Venugopal

    2016-07-01

    Conductive, carbon-free, electrocatalytically active, nanostructured electrodes with ultra-low platinum loading were fabricated using self-assembly of octadecanethiol-coated Au@Pt nanoparticles followed by RF plasma treatment. Bilayer arrays of Au@Pt nanoparticles with platinum loadings of 0.50, 1.04, 1.44, and 1.75 μg cm‑2 (corresponding to 0.5, 1, 1.5 and 2 atomic layer coverage of platinum on nominally 5 nm gold core) were subjected to RF argon plasma treatment for various durations and their electrical conductivity, morphological evolution, and electrocatalytic activity characterized. Samples with monolayer and above platinum coverages exhibit maximum electrochemically active surface areas values of ∼100 m2/gpt and specific activities that are ∼4× to 6× of a reference platinum nanoparticle bilayer array. The underlying gold core influences the structural evolution of the samples upon RF plasma treatment and leads to the formation of highly active Pt(110) facets on the surface at an optimal plasma treatment duration, which also corresponds to the onset of a sharp decline in lateral sheet resistance. The sample having a two atom thick platinum coating has the highest total mass activity of 48 ± 3 m2/g(pt+au), corresponding to 44% Pt atom utilization, while also exhibiting enhanced CO tolerance as well as high methanol oxidation reaction and oxygen reduction reaction activity.

  20. Fabrication of electrodes with ultralow platinum loading by RF plasma processing of self-assembled arrays of Au@Pt nanoparticles.

    PubMed

    Banerjee, Ipshita; Kumaran, V; Santhanam, Venugopal

    2016-07-29

    Conductive, carbon-free, electrocatalytically active, nanostructured electrodes with ultra-low platinum loading were fabricated using self-assembly of octadecanethiol-coated Au@Pt nanoparticles followed by RF plasma treatment. Bilayer arrays of Au@Pt nanoparticles with platinum loadings of 0.50, 1.04, 1.44, and 1.75 μg cm(-2) (corresponding to 0.5, 1, 1.5 and 2 atomic layer coverage of platinum on nominally 5 nm gold core) were subjected to RF argon plasma treatment for various durations and their electrical conductivity, morphological evolution, and electrocatalytic activity characterized. Samples with monolayer and above platinum coverages exhibit maximum electrochemically active surface areas values of ∼100 m(2)/gpt and specific activities that are ∼4× to 6× of a reference platinum nanoparticle bilayer array. The underlying gold core influences the structural evolution of the samples upon RF plasma treatment and leads to the formation of highly active Pt(110) facets on the surface at an optimal plasma treatment duration, which also corresponds to the onset of a sharp decline in lateral sheet resistance. The sample having a two atom thick platinum coating has the highest total mass activity of 48 ± 3 m(2)/g(pt+au), corresponding to 44% Pt atom utilization, while also exhibiting enhanced CO tolerance as well as high methanol oxidation reaction and oxygen reduction reaction activity. PMID:27302373

  1. High optical switching speed and flexible electrochromic display based on WO3 nanoparticles with ZnO nanorod arrays' supported electrode

    NASA Astrophysics Data System (ADS)

    Wang, Mingjun; Fang, Guojia; Yuan, Longyan; Huang, Huihui; Sun, Zhenhua; Liu, Nishuang; Xia, Shanhong; Zhao, Xingzhong

    2009-05-01

    The electrochromic (EC) property of WO3 nanoparticles grown on vertically self-aligned ZnO nanorods (ZNRs) is reported. An electrochromic character display based on WO3 nanoparticle-modified ZnO nanorod arrays on a flexible substrate has been fabricated and demonstrated. The ZNRs were first synthesized on ZnO-seed-coated In2O3:Sn (ITO) glass (1 cm2 cell) and polyethylene terephthalate (PET) (4 cm2 cell) substrates by a low temperature hydrothermal method, and then amorphous WO3 nanoparticles were grown directly on the surface of the ZNRs by the pulsed laser deposition (PLD) method. The ZNR-based EC device shows high transparence, good electrochromic stability and fast switching speed (4.2 and 4 s for coloration and bleaching, respectively, for a 1 cm2 cell). The good performance of the ZNR electrode-based EC display can be attributed to the large surface area, high crystallinity and good electron transport properties of the ZNR arrays. Its high contrast, fast switching, good memory and flexible characteristics indicate it is a promising candidate for flexible electrochromic displays or electronic paper.

  2. Spatial and Temporal Properties of Radiation for Various Electrode Configurations in Arrays of Glass Microchannel Plasma Devices

    NASA Astrophysics Data System (ADS)

    Sung, S. H.; Lee, H. C.; Berger, A. G.; Park, S.-J.; Eden, J. G.

    2009-10-01

    Asymmetric and symmetric structures of microchannel plasma devices having different channel width of 50 -- 200 μm are fabricated on 0.4 mm thick sodalime glass substrate. The aspect ratio -- channel length to width -- has been obtained up to 500. All microplasmas are stable and well confined for several gas pressures of 200 -- 700 Torr, and gas mixtures including ambient air. The examination for spatially-resolved emission shows the tendency that peak intensity increases with increasing pressure. The peak emission intensity for 100 μm wide channel plasmas is doubled while increasing pressure from 200 to 600 Torr, but it also depends on geometrical factors. The temporal radiation in 300 -- 800 nm for various pressures also shows different feature when the microdischarge is driven by AC source. It will be reported that the effect of electrode configuration on the properties of microplasmas.

  3. Hierarchical NiO Nanoflake Arrays on Nickel Foam as a Supercapacitor Electrode with High Capacitance and High Rate Capability.

    PubMed

    Yang, Guangwu; He, Bing; Guo, Wenyue; Zhao, Lianming; Xue, Qingzhong; Li, Hulin

    2016-04-01

    In this paper, we report a simple and cost-effective method for fabricating hierarchical NiO nanoflake arrays on nickel foam. X-ray diffraction, scanning electron microscope and transmission electron microscope are employed to study the morphology and structure of the as-synthesized NiO materials. Galvanostatic charge/discharge measurements demonstrate that the hierarchical NiO nanocomposite displays excellent capacitive behavior between the potential range of -0.1-0.5 V, and a maximum specific capacitance as high as 823 F g-1 can be achieved at a charge/discharge current density of 4 A g-1, and it only decreases by 20% when the current density increases to 12 A g-1. The remarkable electrochemical performance of this hierarchical NiO nanocomposite indicates the areat application potential in supercapacitors. PMID:27451782

  4. Excimer laser deinsulation of Parylene-C on iridium for use in an activated iridium oxide film-coated Utah electrode array

    PubMed Central

    Yoo, Je-Min; Negi, Sandeep; Tathireddy, Prashant; Solzbacher, Florian; Song, Jong-In; Rieth, Loren W.

    2013-01-01

    Implantable microelectrodes provide a measure to electrically stimulate neurons in the brain and spinal cord and record their electrophysiological activity. A material with a high charge capacity such as activated or sputter-deposited iridium oxide film (AIROF or SIROF) is used as an interface. The Utah electrode array (UEA) uses SIROF for its interface material with neural tissue and oxygen plasma etching (OPE) with an aluminium foil mask to expose the active area, where the interface between the electrode and neural tissue is formed. However, deinsulation of Parylene-C using OPE has limitations, including the lack of uniformity in the exposed area and reproducibility. While the deinsulation of Parylene-C using an excimer laser is proven to be an alternative for overcoming the limitations, the iridium oxide (IrOx) suffers from fracture when high laser fluence (>1000 mJ/cm2) is used. Iridium (Ir), which has a much higher fracture resistance than IrOx, can be deposited before excimer laser deinsulation and then the exposed Ir film area can be activated by electrochemical treatment to acquire the AIROF. Characterisation of the laser-ablated Ir film and AIROF by surface analysis (X-ray photoelectron spectroscopy, scanning electron microscope, and atomic force microscope) and electrochemical analysis (electrochemical impedance spectroscopy, and cyclic voltammetry) shows that the damage on the Ir film induced by laser irradiation is significantly less than that on SIROF, and the AIROF has a high charge storage capacity. The results show the potential of the laser deinsulation technique for use in high performance AIROF-coated UEA fabrication. PMID:23458659

  5. LONG-TERM RELIABILITY OF AL2O3 AND PARYLENE C BILAYER ENCAPSULATED UTAH ELECTRODE ARRAY BASED NEURAL INTERFACES FOR CHRONIC IMPLANTATION

    PubMed Central

    Xie, Xianzong; Rieth, Loren; Williams, Layne; Negi, Sandeep; Bhandari, Rajmohan; Caldwell, Ryan; Sharma, Rohit; Tathireddy, Prashant; Solzbacher, Florian

    2014-01-01

    Objective We focus on improving the long-term stability and functionality of neural interfaces for chronic implantation by using bilayer encapsulation. Approach We evaluated the long-term reliability of Utah electrode array (UEA) based neural interfaces encapsulated by 52 nm of atomic layer deposited (ALD) Al2O3 and 6 μm of Parylene C bilayer, and compared these to devices with the baseline Parylene-only encapsulation. Three variants of arrays including wired, wireless, and active UEAs were used to evaluate this bilayer encapsulation scheme, and were immersed in phosphate buffered saline (PBS) at 57 °C for accelerated lifetime testing. Main results The median tip impedance of the bilayer encapsulated wired UEAs increased from 60 kΩ to 160 kΩ during the 960 days of equivalent soak testing at 37 °C, the opposite trend as typically observed for Parylene encapsulated devices. The loss of the iridium oxide tip metallization and etching of the silicon tip in PBS solution contributed to the increase of impedance. The lifetime of fully integrated wireless UEAs was also tested using accelerated lifetime measurement techniques. The bilayer coated devices had stable power-up frequencies at ~910 MHz and constant RF signal strength of -50 dBm during up to 1044 days (still under testing) of equivalent soaking time at 37 °C. This is a significant improvement over the lifetime of ~ 100 days achieved with Parylene-only encapsulation at 37 °C. The preliminary samples of bilayer coated active UEAs with a flip-chip bonded ASIC chip had a steady current draw of ~ 3 mA during 228 days of soak testing at 37 °C. An increase in current draw has been consistently correlated to device failures, so is a sensitive metric for their lifetime. Significance The trends of increasing electrode impedance of wired devices and performance stability of wireless and active devices support the significantly greater encapsulation performance of this bilayer encapsulation compared with Parylene

  6. Long-term reliability of Al2O3 and Parylene C bilayer encapsulated Utah electrode array based neural interfaces for chronic implantation

    NASA Astrophysics Data System (ADS)

    Xie, Xianzong; Rieth, Loren; Williams, Layne; Negi, Sandeep; Bhandari, Rajmohan; Caldwell, Ryan; Sharma, Rohit; Tathireddy, Prashant; Solzbacher, Florian

    2014-04-01

    Objective. We focus on improving the long-term stability and functionality of neural interfaces for chronic implantation by using bilayer encapsulation. Approach. We evaluated the long-term reliability of Utah electrode array (UEA) based neural interfaces encapsulated by 52 nm of atomic layer deposited Al2O3 and 6 µm of Parylene C bilayer, and compared these to devices with the baseline Parylene-only encapsulation. Three variants of arrays including wired, wireless, and active UEAs were used to evaluate this bilayer encapsulation scheme, and were immersed in phosphate buffered saline (PBS) at 57 °C for accelerated lifetime testing. Main results. The median tip impedance of the bilayer encapsulated wired UEAs increased from 60 to 160 kΩ during the 960 days of equivalent soak testing at 37 °C, the opposite trend to that typically observed for Parylene encapsulated devices. The loss of the iridium oxide tip metallization and etching of the silicon tip in PBS solution contributed to the increase of impedance. The lifetime of fully integrated wireless UEAs was also tested using accelerated lifetime measurement techniques. The bilayer coated devices had stable power-up frequencies at ˜910 MHz and constant radio-frequency signal strength of -50 dBm during up to 1044 days (still under testing) of equivalent soaking time at 37 °C. This is a significant improvement over the lifetime of ˜100 days achieved with Parylene-only encapsulation at 37 °C. The preliminary samples of bilayer coated active UEAs with a flip-chip bonded ASIC chip had a steady current draw of ˜3 mA during 228 days of soak testing at 37 °C. An increase in the current draw has been consistently correlated to device failures, so is a sensitive metric for their lifetime. Significance. The trends of increasing electrode impedance of wired devices and performance stability of wireless and active devices support the significantly greater encapsulation performance of this bilayer encapsulation compared

  7. High-performance liquid chromatography and coulometric electrode array detector in serum 25-hydroxyvitamin D(3) and 25-hydroxyvitamin D(2) analyses.

    PubMed

    Nurmi, Tarja; Tuomainen, Tomi-Pekka; Virtanen, Jyrki; Mursu, Jaakko; Voutilainen, Sari

    2013-04-01

    The diode array detector in our high-performance liquid chromatography (HPLC) method for 25-hydroxyvitamin D(3) (25OHD(3)) and 25-hydroxyvitamin D(2) (25OHD(2)) did not perform satisfactorily for measuring human serum concentrations below 30nM. Because of a need for a reliable self-managed method in ongoing and starting vitamin D studies of the laboratory, we decided to develop a chromatographic method applying coulometric electrode array detector (CEAD) and evaluate reliability of the method by participating in the Vitamin D External Quality Assessment Scheme (DEQAS). The limit of quantification for 25OHD(3) and 25OHD(2) of the new method was 0.36pmol on column (3.6nM), and linearity ranged from 5 to 2400nM. Accuracy of the method was 90% for 25OHD(3) and 69% for 25OHD(2). The HPLC-CEAD results from five DEQAS rounds were in line with those of the other participating laboratories using HPLC methods. The HPLC-CEAD results for 25OHD(3) also corresponded to the results obtained with the Chromsystems HPLC method in a certified laboratory. The long-term coefficients of variation for 25OHD(3) were 6.2%, 7.8%, 5.2%, 6.7%, and 7.3% in concentrations of 27.5, 38.7, 48.4, 78.4, and 88.0nM, respectively. The developed HPLC-CEAD method was shown to be applicable for determining 25OHD(3) and 25OHD(2) in human serum samples. PMID:23274364

  8. Self-aligned tip deinsulation of atomic layer deposited Al2O3 and parylene C coated Utah electrode array based neural interfaces

    NASA Astrophysics Data System (ADS)

    Xie, Xianzong; Rieth, Loren; Negi, Sandeep; Bhandari, Rajmohan; Caldwell, Ryan; Sharma, Rohit; Tathireddy, Prashant; Solzbacher, Florian

    2014-03-01

    The recently developed alumina and parylene C bilayer encapsulation improved the lifetime of neural interfaces. Tip deinsulation of Utah electrode array based neural interfaces is challenging due to the complex 3D geometries and high aspect ratios of the devices. A three-step self-aligned process was developed for tip deinsulation of bilayer encapsulated arrays. The deinsulation process utilizes laser ablation to remove parylene C, O2 reactive ion etching to remove carbon and parylene residues, and buffered oxide etch to remove alumina deposited by atomic layer deposition, and expose the IrOx tip metallization. The deinsulated iridium oxide area was characterized by scanning electron microscopy, atomic force microscopy, x-ray photoelectron spectroscopy, and electrochemical impedance spectroscopy to determine the morphology, surface morphology, composition, and electrical properties of the deposited layers and deinsulated tips. The alumina layer was found to prevent the formation of micro cracks on iridium oxide during the laser ablation process, which has been previously reported as a challenge for laser deinsulation of parylene films. The charge injection capacity, charge storage capacity, and impedance of deinsulated iridium oxide were characterized to determine the deinsulation efficacy compared to parylene-only insulation. Deinsulated iridium oxide with bilayer encapsulation had higher charge injection capacity (240 versus 320 nC) and similar electrochemical impedance (2.5 versus 2.5 kΩ) compared to deinsulated iridium oxide with only parylene coating for an area of 2 × 10-4 cm2. Tip impedances were in the range of 20-50 kΩ, with a median of 32 kΩ and a standard deviation of 30 kΩ, showing the effectiveness of the self-aligned deinsulation process for alumina and parylene C bilayer encapsulation. The relatively uniform tip impedance values demonstrated the consistency of tip exposures.

  9. SELF ALIGNED TIP DEINSULATION OF ATOMIC LAYER DEPOSITED AL2O3 AND PARYLENE C COATED UTAH ELECTRODE ARRAY BASED NEURAL INTERFACES

    PubMed Central

    Xie, Xianzong; Rieth, Loren; Negi, Sandeep; Bhandari, Rajmohan; Caldwell, Ryan; Sharma, Rohit; Tathireddy, Prashant; Solzbacher, Florian

    2014-01-01

    The recently developed alumina and Parylene C bi-layer encapsulation improved the lifetime of neural interfaces. Tip deinsulation of Utah electrode array based neural interfaces is challenging due to the complex 3D geometries and high aspect ratios of the devices. A three-step self-aligned process was developed for tip deinsulation of bilayer encapsulated arrays. The deinsulation process utilizes laser ablation to remove Parylene C, O2 reactive ion etching to remove carbon and Parylene residues, and buffered oxide etch to remove alumina deposited by atomic layer deposition, and expose the IrOx tip metallization. The deinsulated iridium oxide area was characterized by scanning electron microscopy, atomic force microscopy, X-ray photoelectron spectroscopy, and electrochemical impedance spectroscopy to determine the morphology, surface morphology, composition, and electrical properties of the deposited layers and deinsulated tips. The alumina layer was found to prevent the formation of micro cracks on iridium oxide during the laser ablation process, which has been previously reported as a challenge for laser deinsulation of Parylene films. The charge injection capacity, charge storage capacity, and impedance of deinsulated iridium oxide were characterized to determine the deinsulation efficacy compared to Parylene-only insulation. Deinsulated iridium oxide with bilayer encapsulation had higher charge injection capacity (240 vs 320 nC) and similar electrochemical impedance (2.5 vs 2.5 kΩ) compared to deinsulated iridium oxide with only Parylene coating for an area of 2 × 10−4 cm2. Tip impedances were in the ranges of 20 to 50 kΩ, with median of 32 KΩ and standard deviation of 30 kΩ, showing the effectiveness of the self-aligned deinsulation process for alumina and Parylene C bi-layer encapsulation. The relatively uniform tip impedance values demonstrated the consistency of tip exposures. PMID:24771981

  10. Optogenetic Mapping of Functional Connectivity in Freely Moving Mice via Insertable Wrapping Electrode Array Beneath the Skull.

    PubMed

    Park, Ah Hyung; Lee, Seung Hyun; Lee, Changju; Kim, Jeongjin; Lee, Han Eol; Paik, Se-Bum; Lee, Keon Jae; Kim, Daesoo

    2016-02-23

    Spatiotemporal mapping of neural interactions through electrocorticography (ECoG) is the key to understanding brain functions and disorders. For the entire brain cortical areas, this approach has been challenging, especially in freely moving states, owing to the need for extensive craniotomy. Here, we introduce a flexible microelectrode array system, termed iWEBS, which can be inserted through a small cranial slit and stably wrap onto the curved cortical surface. Using iWEBS, we measured dynamic changes of signals across major cortical domains, namely, somatosensory, motor, visual and retrosplenial areas, in freely moving mice. iWEBS robustly displayed somatosensory evoked potentials (SEPs) in corresponding cortical areas to specific somatosensory stimuli. We also used iWEBS for mapping functional interactions between cortical areas in the propagation of spike-and-wave discharges (SWDs), the neurological marker of absence seizures, triggered by optogenetic inhibition of a specific thalamic nucleus. This demonstrates that iWEBS represents a significant improvement over conventional ECoG recording methodologies and, therefore, is a competitive recording system for mapping wide-range brain connectivity under various behavioral conditions. PMID:26735496

  11. Design, Fabrication and Characterization of a Low-Impedance 3D Electrode Array System for Neuro-Electrophysiology

    PubMed Central

    Kusko, Mihaela; Craciunoiu, Florea; Amuzescu, Bogdan; Halitzchi, Ferdinand; Selescu, Tudor; Radoi, Antonio; Popescu, Marian; Simion, Monica; Bragaru, Adina; Ignat, Teodora

    2012-01-01

    Recent progress in patterned microelectrode manufacturing technology and microfluidics has opened the way to a large variety of cellular and molecular biosensor-based applications. In this extremely diverse and rapidly expanding landscape, silicon-based technologies occupy a special position, given their statute of mature, consolidated, and highly accessible areas of development. Within the present work we report microfabrication procedures and workflows for 3D patterned gold-plated microelectrode arrays (MEA) of different shapes (pyramidal, conical and high aspect ratio), and we provide a detailed characterization of their physical features during all the fabrication steps to have in the end a reliable technology. Moreover, the electrical performances of MEA silicon chips mounted on standardized connector boards via ultrasound wire-bonding have been tested using non-destructive electrochemical methods: linear sweep and cyclic voltammetry, impedance spectroscopy. Further, an experimental recording chamber package suitable for in vitro electrophysiology experiments has been realized using custom-design electronics for electrical stimulus delivery and local field potential recording, included in a complete electrophysiology setup, and the experimental structures have been tested on newborn rat hippocampal slices, yielding similar performance compared to commercially available MEA equipments. PMID:23208555

  12. A modular 256-channel micro electrode array platform for in vitro and in vivo neural stimulation and recording: BioMEA.

    PubMed

    Charvet, G; Billoint, O; Gharbi, S; Heuschkel, M; Georges, C; Kauffmann, T; Pellissier, A; Yvert, B; Guillemaud, R

    2010-01-01

    In order to understand the dynamics of large neural networks, where information is widely distributed over thousands of cells, one of today's challenges is to successfully monitor the simultaneous activity of as many neurons as possible. This is made possible by using the Micro-Electrode Array (MEA) technology allowing neural cell culture and/or tissue slice experimentation in vitro. Thanks to development of microelectronics' technologies, a novel data acquisition system based on MEA technology has been developed, the BioMEA™. It combines the most advanced MEA biochips with integrated electronics, and a novel user-friendly software interface. To move from prototype (result of the RMNT research project NEUROCOM) to manufactured product, a number of changes have been made. Here, we present a 256-channel MEA data acquisition system with integrated electronics (BioMEA™) allowing simultaneous recording and stimulation of neural networks for in vitro and in vivo applications. This integration is a first step towards an implantable device for BCI (Brain Computer Interface) studies and neural prosthesis. PMID:21095937

  13. In-Vivo Characterization of Glassy Carbon Micro-Electrode Arrays for Neural Applications and Histological Analysis of the Brain Tissue

    NASA Astrophysics Data System (ADS)

    Vomero, Maria

    The aim of this work is to fabricate and characterize glassy carbon Microelectrode Arrays (MEAs) for sensing and stimulating neural activity, and conduct histological analysis of the brain tissue after the implant to determine long-term performance. Neural applications often require robust electrical and electrochemical response over a long period of time, and for those applications we propose to replace the commonly used noble metals like platinum, gold and iridium with glassy carbon. We submit that such material has the potential to improve the performances of traditional neural prostheses, thanks to better charge transfer capabilities and higher electrochemical stability. Great interest and attention is given in this work, in particular, to the investigation of tissue response after several weeks of implants in rodents' brain motor cortex and the associated materials degradation. As part of this work, a new set of devices for Electrocorticography (ECoG) has been designed and fabricated to improve durability and quality of the previous generation of devices, designed and manufactured by the same research group in 2014. In-vivo long-term impedance measurements and brain activity recordings were performed to test the functionality of the neural devices. In-vitro electrical characterization of the carbon electrodes, as well as the study of the adhesion mechanisms between glassy carbon and different substrates is also part of the research described in this book.

  14. Assessment of neurovascular dynamics during transient ischemic attack by the novel integration of micro-electrocorticography electrode array with functional photoacoustic microscopy.

    PubMed

    Liu, Yu-Hang; Liao, Lun-De; Tan, Stacey Sze Hui; Kwon, Ki Yong; Ling, Ji Min; Bandla, Aishwarya; Shih, Yen-Yu Ian; Tan, Eddie Tung Wee; Li, Wen; Ng, Wai Hoe; Lai, Hsin-Yi; Chen, You-Yin; Thakor, Nitish V

    2015-10-01

    This study developed a novel system combining a 16-channel micro-electrocorticography (μECoG) electrode array and functional photoacoustic microscopy (fPAM) to examine changes in neurovascular functions following transient ischemic attack (TIA) in rats. To mimic the pathophysiology of TIA, a modified photothrombotic ischemic model was developed by using 3 min illumination of 5 mW continuous-wave (CW) green laser light focusing on a distal branch of the middle cerebral artery (MCA). Cerebral blood volume (CBV), hemoglobin oxygen saturation (SO2), somatosensory evoked potentials (SSEPs) and alpha-to-delta ratio (ADR) were measured pre- and post-ischemia over a focal cortical region (i.e., 1.5×1.5 mm(2)). Unexpectedly, the SO2, peak-to-peak amplitude (PPA) of SSEPs and ADR recovered and achieved levels greater than the baseline values at the 4th hour post-ischemia induction without any intervention, whereas the CBV value only partially recovered. In other words, transient ischemia led to increased neural activity when the relative CBV was reduced, which may further compromise neural integrity or lead to subsequent vascular disease. This novel μECoG-fPAM system complements currently available imaging techniques and represents a promising technology for studying neurovascular coupling in animal models. PMID:26149348

  15. Vertically aligned ZnO@CuS@PEDOT core@shell nanorod arrays decorated with MnO₂ nanoparticles for a high-performance and semi-transparent supercapacitor electrode.

    PubMed

    Rodríguez-Moreno, Jorge; Navarrete-Astorga, Elena; Dalchiele, Enrique A; Schrebler, Ricardo; Ramos-Barrado, José R; Martín, Francisco

    2014-05-30

    Hybrid nano-architectures with high electrochemical performance for supercapacitors have been designed by growing hierarchical ZnO NRs@CuS@PEDOT@MnO2 core@shell heterostructured nanorod arrays on ITO/glass substrates. This hybrid nano-structured electrode exhibits excellent electrochemical performance, with a high specific areal capacitance of 19.85 mF cm(-2), good rate capability, cycling stability and diffused coloured transparency. PMID:24756158

  16. Electrical Responses and Spontaneous Activity of Human iPS-Derived Neuronal Networks Characterized for 3-month Culture with 4096-Electrode Arrays

    PubMed Central

    Amin, Hayder; Maccione, Alessandro; Marinaro, Federica; Zordan, Stefano; Nieus, Thierry; Berdondini, Luca

    2016-01-01

    The recent availability of human induced pluripotent stem cells (hiPSCs) holds great promise as a novel source of human-derived neurons for cell and tissue therapies as well as for in vitro drug screenings that might replace the use of animal models. However, there is still a considerable lack of knowledge on the functional properties of hiPSC-derived neuronal networks, thus limiting their application. Here, upon optimization of cell culture protocols, we demonstrate that both spontaneous and evoked electrical spiking activities of these networks can be characterized on-chip by taking advantage of the resolution provided by CMOS multielectrode arrays (CMOS-MEAs). These devices feature a large and closely-spaced array of 4096 simultaneously recording electrodes and multi-site on-chip electrical stimulation. Our results show that networks of human-derived neurons can respond to electrical stimulation with a physiological repertoire of spike waveforms after 3 months of cell culture, a period of time during which the network undergoes the expression of developing patterns of spontaneous spiking activity. To achieve this, we have investigated the impact on the network formation and on the emerging network-wide functional properties induced by different biochemical substrates, i.e., poly-dl-ornithine (PDLO), poly-l-ornithine (PLO), and polyethylenimine (PEI), that were used as adhesion promoters for the cell culture. Interestingly, we found that neuronal networks grown on PDLO coated substrates show significantly higher spontaneous firing activity, reliable responses to low-frequency electrical stimuli, and an appropriate level of PSD-95 that may denote a physiological neuronal maturation profile and synapse stabilization. However, our results also suggest that even 3-month culture might not be sufficient for human-derived neuronal network maturation. Taken together, our results highlight the tight relationship existing between substrate coatings and emerging network

  17. High-resolution extracellular stimulation of dispersed hippocampal culture with high-density CMOS multielectrode array based on non-Faradaic electrodes.

    PubMed

    Lei, N; Ramakrishnan, S; Shi, P; Orcutt, J S; Yuste, R; Kam, L C; Shepard, K L

    2011-08-01

    We introduce a method to electrically stimulate individual neurons at single-cell resolution in arbitrary spatiotemporal patterns with precise control over stimulation thresholds. By exploiting a custom microelectronic chip, up to 65,000 non-Faradaic electrodes can be uniquely addressed with electrode density exceeding 6500 electrodes mm(-2). We demonstrate extracellular stimulation of dispersed primary hippocampal neuronal cultures using the chip at single-cell resolution. PMID:21725154

  18. VFSARES-a very fast simulated annealing FORTRAN program for interpretation of 1-D DC resistivity sounding data from various electrode arrays

    NASA Astrophysics Data System (ADS)

    Sharma, Shashi Prakash

    2012-05-01

    Employing the very fast simulated annealing (VFSA) global optimization technique, a FORTRAN program is developed for the interpretation of one-dimensional direct current resistivity sounding data from various electrode arrays. The VFSA optimization depicts various good fitting solutions (models) after analyzing a large number of models within a predefined model space. Various models that yield reasonably well fitting responses with the observed response lie along a narrow elongated region of the model space. Therefore, instead of selecting the global model on the basis of the lowest misfit error, it is better to analyze histograms and probability density functions (PDFs) of such models for depicting the global model. In a multidimensional model space, the most appropriate region to select suitable models to compute the mean model is the one in which the PDF is larger in comparison to the other regions of the model space. Initially, accepted models with misfit errors less than the predefined threshold value are selected and lognormal PDFs for each model parameter are computed. Subsequently, mean model and uncertainties are computed using the models in which each model parameter has a PDF more than the defined threshold value (>68.2%). The mean model computed from such models is very close to the actual subsurface structure (global model). It is observed that the mean model computed using models with a PDF more than 95% for each model parameters yields the actual model. Moreover uncertainty computed using models with such a high PDF and lying in a small model space will be small and it will not be considered as the actual global uncertainty. Resistivity sounding (synthetic and field) data over different subsurface structures are optimized using the VFSA program developed in the present study. Optimization results reveal that the actual model always locates within the estimated uncertainty in the mean model. Since the approach requires much less computing time (a few

  19. Nociception-induced spatial and temporal plasticity of synaptic connection and function in the hippocampal formation of rats: a multi-electrode array recording

    PubMed Central

    Zhao, Xiao-Yan; Liu, Ming-Gang; Yuan, Dong-Liang; Wang, Yan; He, Ying; Wang, Dan-Dan; Chen, Xue-Feng; Zhang, Fu-Kang; Li, Hua; He, Xiao-Sheng; Chen, Jun

    2009-01-01

    Background Pain is known to be processed by a complex neural network (neuromatrix) in the brain. It is hypothesized that under pathological state, persistent or chronic pain can affect various higher brain functions through ascending pathways, leading to co-morbidities or mental disability of pain. However, so far the influences of pathological pain on the higher brain functions are less clear and this may hinder the advances in pain therapy. In the current study, we studied spatiotemporal plasticity of synaptic connection and function in the hippocampal formation (HF) in response to persistent nociception. Results On the hippocampal slices of rats which had suffered from persistent nociception for 2 h by receiving subcutaneous bee venom (BV) or formalin injection into one hand paw, multisite recordings were performed by an 8 × 8 multi-electrode array probe. The waveform of the field excitatory postsynaptic potential (fEPSP), induced by perforant path electrical stimulation and pharmacologically identified as being activity-dependent and mediated by ionotropic glutamate receptors, was consistently positive-going in the dentate gyrus (DG), while that in the CA1 was negative-going in shape in naïve and saline control groups. For the spatial characteristics of synaptic plasticity, BV- or formalin-induced persistent pain significantly increased the number of detectable fEPSP in both DG and CA1 area, implicating enlargement of the synaptic connection size by the injury or acute inflammation. Moreover, the input-output function of synaptic efficacy was shown to be distinctly enhanced by the injury with the stimulus-response curve being moved leftward compared to the control. For the temporal plasticity, long-term potentiation produced by theta burst stimulation (TBS) conditioning was also remarkably enhanced by pain. Moreover, it is strikingly noted that the shape of fEPSP waveform was drastically deformed or split by a TBS conditioning under the condition of

  20. Free standing TiO2 nanotube array electrodes with an ultra-thin Al2O3 barrier layer and TiCl4 surface modification for highly efficient dye sensitized solar cells

    NASA Astrophysics Data System (ADS)

    Gao, Xianfeng; Guan, Dongsheng; Huo, Jingwan; Chen, Junhong; Yuan, Chris

    2013-10-01

    Dye sensitized solar cells were fabricated with free standing TiO2 nanotube (TNT) array films, which were prepared by template assisted atomic layer deposition (ALD) with precise wall thickness control. Efforts to improve the photovoltaic performance were made by using Al2O3 barrier layer coating in conjunction with TiCl4 surface modification. An Al2O3 thin layer was deposited on the TNT electrode by ALD to serve as the charge recombination barrier, but it suffers from the drawback of decreasing the photoelectron injection from dye into TiO2 when the barrier layer became too thick. With the TiCl4 treatment in combination with optimal thickness coating, this problem could be avoided. The co-surface treated electrode presents superior surface property with low recombination rate and good electron transport property. A high conversion efficiency of 8.62% is obtained, which is about 1.8 times that of the device without surface modifications.Dye sensitized solar cells were fabricated with free standing TiO2 nanotube (TNT) array films, which were prepared by template assisted atomic layer deposition (ALD) with precise wall thickness control. Efforts to improve the photovoltaic performance were made by using Al2O3 barrier layer coating in conjunction with TiCl4 surface modification. An Al2O3 thin layer was deposited on the TNT electrode by ALD to serve as the charge recombination barrier, but it suffers from the drawback of decreasing the photoelectron injection from dye into TiO2 when the barrier layer became too thick. With the TiCl4 treatment in combination with optimal thickness coating, this problem could be avoided. The co-surface treated electrode presents superior surface property with low recombination rate and good electron transport property. A high conversion efficiency of 8.62% is obtained, which is about 1.8 times that of the device without surface modifications. Electronic supplementary information (ESI) available: UV-Vis spectra of desorbed N719 dyes from

  1. Fabrication of high performance flexible micro-supercapacitor arrays with hybrid electrodes of MWNT/V2O5 nanowires integrated with a SnO2 nanowire UV sensor

    NASA Astrophysics Data System (ADS)

    Kim, Daeil; Yun, Junyeong; Lee, Geumbee; Ha, Jeong Sook

    2014-09-01

    We report on the on-chip fabrication of high performance flexible micro-supercapacitor (MSC) arrays with hybrid electrodes of multi-walled carbon nanotube (MWNT)/V2O5 nanowire (NW) composites and a solid electrolyte, which could power the SnO2 NW UV sensor integrated on the same flexible substrate. The patterned MSC using hybrid electrodes of MWNT/V2O5 NW composites with 10 vol% of V2O5 NWs exhibited excellent electrochemical performance with a high volume capacitance of 80 F cm-3 at a scan rate of 10 mV s-1 in a PVA-LiCl electrolyte and good cycle performance to maintain 82% of the capacitance after 10 000 cycles at a current density of 11.6 A cm-3. The patterned MSC also showed an excellent energy density of 6.8 mW h cm-3, comparable to that of a Li-thin film battery (1-10 mW h cm-3), and a power density of 80.8 W cm-3 comparable to that of state-of-the-art MSCs. In addition, the flexible MSC array on a PET substrate showed mechanical stability over bending with a bending radius down to 1.5 mm under both compressive and tensile stress. Even after 1000 bending cycles at a bending radius of 7 mm, 94% of the initial capacitance was maintained. Furthermore, we have shown the operation of a SnO2 NW UV sensor using such a fabricated MSC array integrated into the same circuit on the PET substrate.We report on the on-chip fabrication of high performance flexible micro-supercapacitor (MSC) arrays with hybrid electrodes of multi-walled carbon nanotube (MWNT)/V2O5 nanowire (NW) composites and a solid electrolyte, which could power the SnO2 NW UV sensor integrated on the same flexible substrate. The patterned MSC using hybrid electrodes of MWNT/V2O5 NW composites with 10 vol% of V2O5 NWs exhibited excellent electrochemical performance with a high volume capacitance of 80 F cm-3 at a scan rate of 10 mV s-1 in a PVA-LiCl electrolyte and good cycle performance to maintain 82% of the capacitance after 10 000 cycles at a current density of 11.6 A cm-3. The patterned MSC also

  2. Fabrication of high performance flexible micro-supercapacitor arrays with hybrid electrodes of MWNT/V2O5 nanowires integrated with a SnO2 nanowire UV sensor.

    PubMed

    Kim, Daeil; Yun, Junyeong; Lee, Geumbee; Ha, Jeong Sook

    2014-10-21

    We report on the on-chip fabrication of high performance flexible micro-supercapacitor (MSC) arrays with hybrid electrodes of multi-walled carbon nanotube (MWNT)/V2O5 nanowire (NW) composites and a solid electrolyte, which could power the SnO2 NW UV sensor integrated on the same flexible substrate. The patterned MSC using hybrid electrodes of MWNT/V2O5 NW composites with 10 vol% of V2O5 NWs exhibited excellent electrochemical performance with a high volume capacitance of 80 F cm(-3) at a scan rate of 10 mV s(-1) in a PVA-LiCl electrolyte and good cycle performance to maintain 82% of the capacitance after 10,000 cycles at a current density of 11.6 A cm(-3). The patterned MSC also showed an excellent energy density of 6.8 mW h cm(-3), comparable to that of a Li-thin film battery (1-10 mW h cm(-3)), and a power density of 80.8 W cm(-3) comparable to that of state-of-the-art MSCs. In addition, the flexible MSC array on a PET substrate showed mechanical stability over bending with a bending radius down to 1.5 mm under both compressive and tensile stress. Even after 1000 bending cycles at a bending radius of 7 mm, 94% of the initial capacitance was maintained. Furthermore, we have shown the operation of a SnO2 NW UV sensor using such a fabricated MSC array integrated into the same circuit on the PET substrate. PMID:25184811

  3. \\documentclass[12pt]{minimal} \\usepackage{amsmath} \\usepackage{wasysym} \\usepackage{amsfonts} \\usepackage{amssymb} \\usepackage{amsbsy} \\usepackage{upgreek} \\usepackage{mathrsfs} \\setlength{\\oddsidemargin}{-69pt} \\begin{document} }{}${\\mbi{\\mu }}$\\end{document}-Foil Polymer Electrode Array for Intracortical Neural Recordings

    PubMed Central

    Köhler, Per; Granmo, Marcus; Schouenborg, Jens; Bengtsson, Martin; Wallman, Lars

    2014-01-01

    We have developed a multichannel electrode array—termed \\documentclass[12pt]{minimal} \\usepackage{amsmath} \\usepackage{wasysym} \\usepackage{amsfonts} \\usepackage{amssymb} \\usepackage{amsbsy} \\usepackage{upgreek} \\usepackage{mathrsfs} \\setlength{\\oddsidemargin}{-69pt} \\begin{document} }{}\\(\\mu \\) \\end{document}-foil—that comprises ultrathin and flexible electrodes protruding from a thin foil at fixed distances. In addition to allowing some of the active sites to reach less compromised tissue, the barb-like protrusions that also serves the purpose of anchoring the electrode array into the tissue. This paper is an early evaluation of technical aspects and performance of this electrode array in acute in vitro/in vivo experiments. The interface impedance was reduced by up to two decades by electroplating the active sites with platinum black. The platinum black also allowed for a reduced phase lag for higher frequency components. The distance between the protrusions of the electrode array was tailored to match the architecture of the rat cerebral cortex. In vivo acute measurements confirmed a high signal-to-noise ratio for the neural recordings, and no significant crosstalk between recording channels. PMID:27170864

  4. Electrode compositions

    DOEpatents

    Block, J.; Fan, X.

    1998-10-27

    An electrode composition is described for use as an electrode in a non-aqueous battery system. The electrode composition contains an electrically active powder in a solid polymer and, as a dispersant, a C{sub 8}-C{sub 15} alkyl capped oligomer of a hexanoic acid that is electrochemically inert at 2.5--4.5 volts.

  5. Electrode compositions

    DOEpatents

    Block, Jacob; Fan, Xiyun

    1998-01-01

    An electrode composition for use as an electrode in a non-aqueous battery system. The electrode composition contains an electrically active powder in a solid polymer and, as a dispersant, a C.sub.8 -C.sub.15 alkyl capped oligomer of a hexanoic acid that is electrochemically inert at 2.5-4.5 volts.

  6. Magnetohydrodynamic electrode

    DOEpatents

    Boquist, Carl W.; Marchant, David D.

    1978-01-01

    A ceramic-metal composite suitable for use in a high-temperature environment consists of a refractory ceramic matrix containing 10 to 50 volume percent of a continuous high-temperature metal reinforcement. In a specific application of the composite, as an electrode in a magnetohydrodynamic generator, the one surface of the electrode which contacts the MHD fluid may have a layer of varying thickness of nonreinforced refractory ceramic for electrode temperature control. The side walls of the electrode may be coated with a refractory ceramic insulator. Also described is an electrode-insulator system for a MHD channel.

  7. Double-layer electrode based on TiO2 nanotubes arrays for enhancing photovoltaic properties in dye-sensitized solar cells.

    PubMed

    He, Zuoli; Que, Wenxiu; Sun, Peng; Ren, Jiangbo

    2013-12-26

    The present work reports a rapid and facile method to fabricate a novel double-layer TiO2 photoanode, which is based on highly ordered TiO2 nanotube arrays and monodispersive scattering microspheres. This double-layer TiO2 sphere/TNTA photoanode have got many unique structural and optical properties from TiO2 scattering microspheres, such as high specific surface area, multiple interparticle scattering, and efficient light-harvesting. Results indicate that this as-fabricated double-layer TiO2 sphere/TNTA front-illumination dye-sensitized solar cell, which is fabricated from the TiO2 nanotube arrays with a 17.4 μm length after TiCl4 treatment, exhibits a pronounced power conversion efficiency of 7.24% under an AM1.5 G irradiation, which can be attributed to the increased incident photon-to-current conversion and light-harvesting efficiency. PMID:24304127

  8. Working Electrodes

    NASA Astrophysics Data System (ADS)

    Komorsky-Lovrić, Šebojka

    In electrochemistry an electrode is an electronic conductor in contact with an ionic conductor. The electronic conductor can be a metal, or a semiconductor, or a mixed electronic and ionic conductor. The ionic conductor is usually an electrolyte solution; however, solid electrolytes and ionic melts can be used as well. The term "electrode" is also used in a technical sense, meaning the electronic conductor only. If not specified otherwise, this meaning of the term "electrode" is the subject of the present chapter. In the simplest case the electrode is a metallic conductor immersed in an electrolyte solution. At the surface of the electrode, dissolved electroactive ions change their charges by exchanging one or more electrons with the conductor. In this electrochemical reaction both the reduced and oxidized ions remain in solution, while the conductor is chemically inert and serves only as a source and sink of electrons. The technical term "electrode" usually also includes all mechanical parts supporting the conductor (e.g., a rotating disk electrode or a static mercury drop electrode). Furthermore, it includes all chemical and physical modifications of the conductor, or its surface (e.g., a mercury film electrode, an enzyme electrode, and a carbon paste electrode). However, this term does not cover the electrolyte solution and the ionic part of a double layer at the electrode/solution interface. Ion-selective electrodes, which are used in potentiometry, will not be considered in this chapter. Theoretical and practical aspects of electrodes are covered in various books and reviews [1-9].

  9. Double interconnection fuel cell array

    DOEpatents

    Draper, Robert; Zymboly, Gregory E.

    1993-01-01

    A fuel cell array (10) is made, containing number of tubular, elongated fuel cells (12) which are placed next to each other in rows (A, B, C, D), where each cell contains inner electrodes (14) and outer electrodes (18 and 18'), with solid electrolyte (16 and 16') between the electrodes, where the electrolyte and outer electrode are discontinuous, having two portions, and providing at least two opposed discontinuities which contain at least two oppositely opposed interconnections (20 and 20') contacting the inner electrode (14), each cell (12) having only three metallic felt electrical connectors (22) which contact surrounding cells, where each row is electrically connected to the other.

  10. Statistical generation of training sets for measuring NO3(-), NH4(+) and major ions in natural waters using an ion selective electrode array.

    PubMed

    Mueller, Amy V; Hemond, Harold F

    2016-05-18

    Knowledge of ionic concentrations in natural waters is essential to understand watershed processes. Inorganic nitrogen, in the form of nitrate and ammonium ions, is a key nutrient as well as a participant in redox, acid-base, and photochemical processes of natural waters, leading to spatiotemporal patterns of ion concentrations at scales as small as meters or hours. Current options for measurement in situ are costly, relying primarily on instruments adapted from laboratory methods (e.g., colorimetric, UV absorption); free-standing and inexpensive ISE sensors for NO3(-) and NH4(+) could be attractive alternatives if interferences from other constituents were overcome. Multi-sensor arrays, coupled with appropriate non-linear signal processing, offer promise in this capacity but have not yet successfully achieved signal separation for NO3(-) and NH4(+)in situ at naturally occurring levels in unprocessed water samples. A novel signal processor, underpinned by an appropriate sensor array, is proposed that overcomes previous limitations by explicitly integrating basic chemical constraints (e.g., charge balance). This work further presents a rationalized process for the development of such in situ instrumentation for NO3(-) and NH4(+), including a statistical-modeling strategy for instrument design, training/calibration, and validation. Statistical analysis reveals that historical concentrations of major ionic constituents in natural waters across New England strongly covary and are multi-modal. This informs the design of a statistically appropriate training set, suggesting that the strong covariance of constituents across environmental samples can be exploited through appropriate signal processing mechanisms to further improve estimates of minor constituents. Two artificial neural network architectures, one expanded to incorporate knowledge of basic chemical constraints, were tested to process outputs of a multi-sensor array, trained using datasets of varying degrees of

  11. Study on dynamics of photoexcited charge injection and trapping in CdS quantum dots sensitized TiO2 nanowire array film electrodes

    NASA Astrophysics Data System (ADS)

    Pang, Shan; Cheng, Ke; Yuan, Zhanqiang; Xu, Suyun; Cheng, Gang; Du, Zuliang

    2014-05-01

    The photoexcited electrons transfer dynamics of the CdS quantum dots (QDs) deposited in TiO2 nanowire array films are studied using surface photovoltage (SPV) and transient photovoltage (TPV) techniques. By comparing the SPV results with different thicknesses of QDs layers, we can separate the dynamic characteristics of photoexcited electrons injection and trapping. It is found that the TPV signals of photoexcited electrons trapped in the CdS QDs occur at timescales of about 2 × 10-8 s, which is faster than that of the photoexcited electrons injected from CdS into TiO2. More than 90 nm of the thickness of the CdS QDs layer will seriously affect the photoexcited electrons transfer and injection.

  12. Study on dynamics of photoexcited charge injection and trapping in CdS quantum dots sensitized TiO{sub 2} nanowire array film electrodes

    SciTech Connect

    Pang, Shan; Cheng, Ke; Yuan, Zhanqiang; Xu, Suyun; Cheng, Gang; Du, Zuliang

    2014-05-19

    The photoexcited electrons transfer dynamics of the CdS quantum dots (QDs) deposited in TiO{sub 2} nanowire array films are studied using surface photovoltage (SPV) and transient photovoltage (TPV) techniques. By comparing the SPV results with different thicknesses of QDs layers, we can separate the dynamic characteristics of photoexcited electrons injection and trapping. It is found that the TPV signals of photoexcited electrons trapped in the CdS QDs occur at timescales of about 2 × 10{sup −8} s, which is faster than that of the photoexcited electrons injected from CdS into TiO{sub 2}. More than 90 nm of the thickness of the CdS QDs layer will seriously affect the photoexcited electrons transfer and injection.

  13. Liquid electrode

    DOEpatents

    Ekechukwu, Amy A.

    1994-01-01

    A dropping electrolyte electrode for use in electrochemical analysis of non-polar sample solutions, such as benzene or cyclohexane. The liquid electrode, preferably an aqueous salt solution immiscible in the sample solution, is introduced into the solution in dropwise fashion from a capillary. The electrolyte is introduced at a known rate, thus, the droplets each have the same volume and surface area. The electrode is used in making standard electrochemical measurements in order to determine properties of non-polar sample solutions.

  14. A new strategy for achieving vertically-erected and hierarchical TiO2 nanosheets array/carbon cloth as a binder-free electrode for protein impregnation, direct electrochemistry and mediator-free glucose sensing.

    PubMed

    Liu, Jing; He, Ziming; Khoo, Si Yun; Tan, Timothy Thatt Yang

    2016-03-15

    We present a new approach to directly grow uniform and highly-ordered TiO2 nanosheets array (NSA) on a low-cost flexible carbon cloth substrate while simultaneously fulfill precise TiO2 nanostructure tailoring and crystal phase control. The unique vertically-erected TiO2 NSA/carbon cloth with hierarchical structures was directly explored as electrode for enzyme immobilization and biosensing applications without suffering any influences of insulating binders usually used to fix nanomaterials on conductive substrates during sensor fabrications. Efficient direct electron transfer was successfully achieved for glucose oxidase (GOx) immobilized on the TiO2 NSA/carbon cloth, which produces a stable, mediator-free glucose sensor with good selectivity, high-sensitivity (52 μA mM(-1)cm(-2)), low response time (<5s) and low detection limit (23.4 μM, S/N=3). The mechanism of the superior direct electrochemical properties and sensing performance was investigated in detail, and discussed from the aspects of material nanostructure and crystalline form of TiO2 NSA, and an intimate contact between TiO2 and carbon cloth resulted from direct crystallization and growth of TiO2 nanosheets on the substrate. PMID:26528809

  15. Microfabricated ion trap array

    DOEpatents

    Blain, Matthew G.; Fleming, James G.

    2006-12-26

    A microfabricated ion trap array, comprising a plurality of ion traps having an inner radius of order one micron, can be fabricated using surface micromachining techniques and materials known to the integrated circuits manufacturing and microelectromechanical systems industries. Micromachining methods enable batch fabrication, reduced manufacturing costs, dimensional and positional precision, and monolithic integration of massive arrays of ion traps with microscale ion generation and detection devices. Massive arraying enables the microscale ion traps to retain the resolution, sensitivity, and mass range advantages necessary for high chemical selectivity. The reduced electrode voltage enables integration of the microfabricated ion trap array with on-chip circuit-based rf operation and detection electronics (i.e., cell phone electronics). Therefore, the full performance advantages of the microfabricated ion trap array can be realized in truly field portable, handheld microanalysis systems.

  16. Liquid electrode

    DOEpatents

    Ekechukwu, A.A.

    1994-07-05

    A dropping electrolyte electrode is described for use in electrochemical analysis of non-polar sample solutions, such as benzene or cyclohexane. The liquid electrode, preferably an aqueous salt solution immiscible in the sample solution, is introduced into the solution in dropwise fashion from a capillary. The electrolyte is introduced at a known rate, thus, the droplets each have the same volume and surface area. The electrode is used in making standard electrochemical measurements in order to determine properties of non-polar sample solutions. 2 figures.

  17. Pyroelectric detector arrays

    NASA Technical Reports Server (NTRS)

    Fripp, A. L.; Robertson, J. B.; Breckenridge, R. (Inventor)

    1982-01-01

    A pyroelectric detector array and the method for using it are described. A series of holes formed through a silicon dioxide layer on the surface of a silicon substrate forms the mounting fixture for the pyroelectric detector array. A series of nontouching strips of indium are formed around the holes to make contact with the backside electrodes and form the output terminals for individual detectors. A pyroelectric detector strip with front and back electrodes, respectively, is mounted over the strips. Biasing resistors are formed on the surface of the silicon dioxide layer and connected to the strips. A metallized pad formed on the surface of layer is connected to each of the biasing resistors and to the film to provide the ground for the pyroelectric detector array.

  18. Pyroelectric detector arrays

    NASA Technical Reports Server (NTRS)

    Fripp, A. L.; Robertson, J. B.; Breckenridge, R. A. (Inventor)

    1982-01-01

    A pryoelectric detector array and the method for making it are described. A series of holes formed through a silicon dioxide layer on the surface of a silicon substrate forms the mounting fixture for the pyroelectric detector array. A series of nontouching strips of indium are formed around the holes to make contact with the backside electrodes and form the output terminals for individual detectors. A pyroelectric detector strip with front and back electrodes, respectively, is mounted over the strip. Biasing resistors are formed on the surface of the silicon dioxide layer and connected to the strips. A metallized pad formed on the surface of the layer is connected to each of the biasing resistors and to the film to provide the ground for the pyroelectric detector array.

  19. Flexible carbon nanotubes electrode for neural recording.

    PubMed

    Lin, Chia-Min; Lee, Yu-Tao; Yeh, Shih-Rung; Fang, Weileun

    2009-05-15

    This paper demonstrates a novel flexible carbon nanotubes (CNTs) electrode array for neural recording. In this device, the CNTs electrode arrays are partially embedded into the flexible Parylene-C film using a batch microfabrication process. Through this fabrication process, the CNTs can be exposed to increase the total sensing area of an electrode. Thus, the flexible CNTs electrode of low impedance is realized. In application, the flexible CNTs electrode has been employed to record the neural signal of a crayfish nerve cord for in vitro recording. The measurements demonstrate the superior performance of the presented flexible CNTs electrode with low impedance (11.07 kohms at 1 kHz) and high peak-to-peak amplitude action potential (about 410 microV). In addition, the signal-to-noise ratio (SNR) of the presented flexible CNTs electrode is about 257, whereas the SNR of the reference (a pair of Teflon-coated silver wires) is only 79. The simultaneous recording of the flexible CNTs electrode array is also demonstrated. Moreover, the flexible CNTs electrode has been employed to successfully record the spontaneous spikes from the crayfish nerve cord. The amplitude of the spontaneous peak-to-peak response is about 25 microV. PMID:19272765

  20. Oriented nanotube electrodes for lithium ion batteries and supercapacitors

    DOEpatents

    Frank, Arthur J.; Zhu, Kai; Wang, Qing

    2013-03-05

    An electrode having an oriented array of multiple nanotubes is disclosed. Individual nanotubes have a lengthwise inner pore defined by interior tube walls which extends at least partially through the length of the nanotube. The nanotubes of the array may be oriented according to any identifiable pattern. Also disclosed is a device featuring an electrode and methods of fabrication.

  1. Optimal electrode diameter in relation to volume of the cochlea.

    PubMed

    Gnansia, D; Demarcy, T; Vandersteen, C; Raffaelli, C; Guevara, N; Delingette, H; Ayache, N

    2016-06-01

    The volume of the cochlea is a key parameter for electrode-array design. Indeed, it constrains the diameter of the electrode-array for low-traumatic positioning in the scala timpani. The present report shows a model of scala timpani volume extraction from temporal bones images in order to estimate a maximum diameter of an electrode-array. Nine temporal bones were used, and passed to high-resolution computed tomography scan. Using image-processing techniques, scala timpani were extracted from images, and cross-section areas were estimated along cochlear turns. Cochlear implant electrode-array was fitted in these cross-sections. Results show that the electrode-array diameter is small enough to fit in the scala timpani, however the diameter is restricted at the apical part. PMID:27246746

  2. Size-variable droplet actuation by interdigitated electrowetting electrode

    NASA Astrophysics Data System (ADS)

    Chen, Jianfeng; Yu, Yuhua; Li, Jia; Lai, Yongjun; Zhou, Jia

    2012-12-01

    We propose electrowetting on dielectric (EWOD) electrodes to actuate size-variable droplets. By using interdigitated fingers and maximizing them in optimized construction, we can control droplets in different sizes with the same electrode array automatically. We both do the theory calculation and experiment verification to study the electrode with rectangular fingers. It is found that the electrode with triangle fingers can actuate droplets as small as 1/36 of that actuated by conventional square electrode array. It can actuate large droplets more efficiently than rectangular fingers. This work provides an approach to achieve multifunctional EWOD devices in the future.

  3. Nanopillar array structures for enhancing biosensing performance

    PubMed Central

    Anandan, Venkataramani; Rao, Yeswanth L; Zhang, Guigen

    2006-01-01

    Fabrication of metallic nanopillar array structures and their application as electrodes in electrochemical-based biosensors are discussed in this report. Vertically standing nanopillar array structures were fabricated using an electrodeposition technique and their electrochemical characteristics were evaluated. For possible use in biosensing applications, these standing nanopillars should have sufficient mechanical stability to sustain the capillary forces caused by the nanopillar – liquid interactions in aqueous environment and should provide increased signal response in an electrochemical process. Our results showed that the developed nanopillar arrays were mechanically stable in aqueous environments and the nanostructured electrodes exhibited increased electrochemical response compared with flat electrodes. PMID:17722264

  4. Cermet electrode

    DOEpatents

    Maskalick, Nicholas J.

    1988-08-30

    Disclosed is a cermet electrode consisting of metal particles of nickel, cobalt, iron, or alloys or mixtures thereof immobilized by zirconia stabilized in cubic form which contains discrete deposits of about 0.1 to about 5% by weight of praseodymium, dysprosium, terbium, or a mixture thereof. The solid oxide electrode can be made by covering a substrate with particles of nickel, cobalt, iron, or mixtures thereof, growing a stabilized zirconia solid oxide skeleton around the particles thereby immobilizing them, contacting the skeleton with a compound of praseodymium, dysprosium, terbium, or a mixture thereof, and heating the skeleton to a temperature of at least 500.degree. C. The electrode can also be made by preparing a slurry of nickel, cobalt, iron, or mixture and a compound of praseodymium, dysprosium, terbium, or a mixture thereof, depositing the slurry on a substrate, heating the slurry to dryness, and growing a stabilized zirconia skeleton around the metal particles.

  5. Magnetohydrodynamic electrode

    DOEpatents

    Marchant, David D.; Killpatrick, Don H.

    1978-01-01

    An electrode capable of withstanding high temperatures and suitable for use as a current collector in the channel of a magnetohydrodynamic (MHD) generator consists of a sintered powdered metal base portion, the upper surface of the base being coated with a first layer of nickel aluminide, an intermediate layer of a mixture of nickel aluminide - refractory ceramic on the first layer and a third or outer layer of a refractory ceramic material on the intermediate layer. The sintered powdered metal base resists spalling by the ceramic coatings and permits greater electrode compliance to thermal shock. The density of the powdered metal base can be varied to allow optimization of the thermal conductivity of the electrode and prevent excess heat loss from the channel.

  6. Photoelectrochemical electrodes

    NASA Technical Reports Server (NTRS)

    Williams, R. M.; Rembaum, A. (Inventor)

    1983-01-01

    The surface of a moderate band gap semiconductor such as p-type molybdenum sulfide is modified to contain an adherent film of charge mediating ionene polymer containing an electroactive unit such as bipyridimium. Electron transport between the electrode and the mediator film is favorable and photocorrosion and recombination processes are suppressed. Incorporation of particles of catalyst such as platinum within the film provides a reduction in overvoltage. The polymer film is readily deposited on the electrode surface and can be rendered stable by ionic or addition crosslinking. Catalyst can be predispersed in the polymer film or a salt can be impregnated into the film and reduced therein.

  7. Nanoelectrode array for electrochemical analysis

    DOEpatents

    Yelton, William G.; Siegal, Michael P.

    2009-12-01

    A nanoelectrode array comprises a plurality of nanoelectrodes wherein the geometric dimensions of the electrode controls the electrochemical response, and the current density is independent of time. By combining a massive array of nanoelectrodes in parallel, the current signal can be amplified while still retaining the beneficial geometric advantages of nanoelectrodes. Such nanoelectrode arrays can be used in a sensor system for rapid, non-contaminating field analysis. For example, an array of suitably functionalized nanoelectrodes can be incorporated into a small, integrated sensor system that can identify many species rapidly and simultaneously under field conditions in high-resistivity water, without the need for chemical addition to increase conductivity.

  8. Fabrication of an optoelectrochemical microring array.

    PubMed

    Szunerits, Sabine; Walt, David R

    2002-04-01

    In this paper, we describe a novel approach for fabricating an optoelectrochemical microring array. The array was fabricated by coating individual optical fibers of 25-microm diameter with a 1-microm layer of gold nanoparticles via electroless gold deposition. A SAM layer around the individual gold-coated imaging fibers prevented electrical contact with neighboring ring electrodes. To achieve better mechanical stability and to make the device more practical, the electrode/fiber bundle comprising approximately 600 individual gold-coated optical fibers was dipped into epoxy. By polishing the ends of such a device, a ring microelectrode array comprising 600 individual and insulated ring electrodes was formed. To limit diffusional overlap of current, only 20-30% of the microring fiber/electrodes were wired. The inner diameter of the ring electrode is fixed by the diameter of the individual optical fibers (25 microm), while the outer radius is determined by the thickness of the deposited gold. The array was characterized using ferrocyanide in aqueous solution as a model electroactive species to demonstrate that this microelectrode array format exhibits steady-state currents at short response times. In addition, cyclic voltammetry experiments were performed using conventional potentiostats due to the amplification of current inherent in the array format. Finally, electrochemiluminescence at the ring electrode array was demonstrated through the oxidation of Ru(bpy)3(2+) in tri-n-propylamide in a pH 7 phosphate buffer solution, where the light generated was collected and detected via the fiber bundle. PMID:12033265

  9. Dielectrophoretic systems without embedded electrodes

    DOEpatents

    Cummings, Eric B.; Singh, Anup K.

    2006-03-21

    Method and apparatus for dielectrophoretic separation of particles in a fluid based using array of insulating structures arranged in a fluid flow channel. By utilizing an array of insulating structures, a spatially inhomogeneous electric field is created without the use of the embedded electrodes conventionally employed for dielectrophoretic separations. Moreover, by using these insulating structures a steady applied electric field has been shown to provide for dielectrophoresis in contrast to the conventional use of an alternating electric field. In a uniform array of posts, dielectrophoretic effects have been produced flows having significant pressure-driven and electrokinetic transport. Above a threshold applied electric field, filaments of concentrated and rarefied particles appear in the flow as a result of dielectrophoresis. Above a higher threshold applied voltage, dielectrophoresis produces zones of highly concentrated and immobilized particles. These patterns are strongly influenced by the angle of the array of insulating structures with respect to the mean applied electric field and the shape of the insulating structures.

  10. Flexible ultrasonic array sensors for health monitoring

    NASA Astrophysics Data System (ADS)

    Kobayashi, M.; Wu, K.-T.; Song, L.; Liu, Q.; Jen, C.-K.

    2007-04-01

    Flexible ultrasonic array transducers which can be attached to the desired structures or materials for nondestructive testing and structural health monitoring applications at room and elevated temperatures are developed. These flexible ultrasonic transducers (UTs) arrays consist of a thin polyimide membrane with a bottom electrode or stainless steel foil, a piezoelectric lead-zirconate-titanate (PZT) composite film and top electrodes. The flexibility is realized owing to the porosity of piezoelectric film and the thinness of substrate and electrodes. Top and bottom electrode materials are silver paste, silver paint or electroless plated nickel alloys. The UT array is configured by the several top electrodes. The flexible UT has been successfully tested at 150°C and also immersed into water as immersion ultrasonic probe operated in the pulse-echo mode with good signal to noise ratio.

  11. Fracture characterisation using geoelectric null-arrays

    NASA Astrophysics Data System (ADS)

    Falco, Pierik; Negro, François; Szalai, Sándor; Milnes, Ellen

    2013-06-01

    The term "geoelectric null-array" is used for direct current electrode configurations yielding a potential difference of zero above a homogeneous half-space. This paper presents a comparative study of the behaviour of three null-arrays, midpoint null-array (MAN), Wenner-γ null-array and Schlumberger null-array in response to a fracture, both in profiling and in azimuthal mode. The main objective is to determine which array(s) best localise fractures or best identify their orientation. Forward modelling of the three null-arrays revealed that the Wenner-γ and Schlumberger null-arrays localise vertical fractures the most accurately, whilst the midpoint null-array combined with the Schlumberger null-array allows accurate orientation of a fracture. Numerical analysis then served as a basis to interpret the field results. Field test measurements were carried out above a quarry in Les Breuleux (Switzerland) with the three null-arrays and classical arrays. The results were cross-validated with quarry-wall geological mapping. In real field circumstances, the Wenner-γ null-array proved to be the most efficient and accurate in localising fractures. The orientations of the fractures according to the numerical results were most efficiently determined with the midpoint null-array, whilst the Schlumberger null-array adds accuracy to the results. This study shows that geoelectrical null-arrays are more suitable than classical arrays for the characterisation of fracture geometry.

  12. Self-guarding Schottky barrier infrared detector array

    NASA Astrophysics Data System (ADS)

    Shepherd, F. D., Jr.; Pellegrini, P. W.; Ludington, C. E.; Weeks, M. M.

    1985-07-01

    A two dimensional focal plane array of Schottky photodiodes on a silicon substrate for infrared imaging is presented. The array is designed for mating with multiplexing circuitry and has a self-guarding feature wherein adjacent Schottky electrodes act as guard electrodes. This feature allows a substantial increase of the focal plane area coverage ratio.

  13. Magnetic arrays

    DOEpatents

    Trumper, D.L.; Kim, W.; Williams, M.E.

    1997-05-20

    Electromagnet arrays are disclosed which can provide selected field patterns in either two or three dimensions, and in particular, which can provide single-sided field patterns in two or three dimensions. These features are achieved by providing arrays which have current densities that vary in the windings both parallel to the array and in the direction of array thickness. 12 figs.

  14. Magnetic arrays

    SciTech Connect

    Trumper, David L.; Kim, Won-jong; Williams, Mark E.

    1997-05-20

    Electromagnet arrays which can provide selected field patterns in either two or three dimensions, and in particular, which can provide single-sided field patterns in two or three dimensions. These features are achieved by providing arrays which have current densities that vary in the windings both parallel to the array and in the direction of array thickness.

  15. Thin-Film Microelectrode Arrays for Biomedical Applications

    NASA Astrophysics Data System (ADS)

    Cheung, Karen C.

    Microfabrication offers many advantages for the batch manufacture of reliable, microscale electrode arrays. Such arrays have been used for highly localized recording and stimulation of neural tissue. This chapter gives a survey of the most commonly used materials and methods in the fabrication of microelectrodes, including planar silicon-based electrodes, three-dimensional silicon-based electrodes, sieve electrodes, and polymer-based structures. Several techniques for electrode modification with nanostructures are described, including carbon nanotube and conductive polymer nanotube coatings. Biocompatibility is described in the context of central nervous system response to chronically implanted devices, which leads to the eventual development of a glial scar.

  16. Electrostatic coalescence system with independent AC and DC hydrophilic electrodes

    DOEpatents

    Hovarongkura, A. David; Henry, Jr., Joseph D.

    1981-01-01

    An improved electrostatic coalescence system is provided in which independent AC and DC hydrophilic electrodes are employed to provide more complete dehydration of an oil emulsion. The AC field is produced between an AC electrode array and the water-oil interface wherein the AC electrode array is positioned parallel to the interface which acts as a grounded electrode. The emulsion is introduced into the AC field in an evenly distributed manner at the interface. The AC field promotes drop-drop and drop-interface coalescence of the water phase in the entering emulsion. The continuous oil phase passes upward through the perforated AC electrode array and enters a strong DC field produced between closely spaced DC electrodes in which small dispersed droplets of water entrained in the continuous phase are removed primarily by collection at hydrophilic DC electrodes. Large droplets of water collected by the electrodes migrate downward through the AC electrode array to the interface. All phase separation mechanisms are utilized to accomplish more complete phase separation.

  17. Injector-concentrator electrodes for microchannel electrophoresis

    DOEpatents

    Swierkowski, Stefan P.

    2003-05-06

    An input port geometry, with injector-concentrator electrodes, for planar microchannel array for electrophoresis. This input port geometry enables efficient extraction and injection of the DNA sample from a single input port. The geometry, which utilizes injector-concentrator electrodes, allows simultaneous concentration, in different channels, of the sample into a longitudinally narrow strip just before releasing it for a run with enhanced injection spatial resolution, and time resolution. Optional multiple electrodes, at a different bias than the concentrator electrodes, may be used to discriminate against sample impurity ions. Electrode passivation can be utilized to prevent electrolysis. An additional electrode in or on the input hole can better define the initial loading. The injector-concentrator electrodes are positioned so that they cross the drift channel in a narrow strip at the bond plane between the top and bottom plates of the instrument and are located close to the inlet hole. The optional sample purification electrodes are located at a greater distance from the input hole than the injector-concentrate electrodes.

  18. Focused shock spark discharge drill using multiple electrodes

    DOEpatents

    Moeny, William M.; Small, James G.

    1988-01-01

    A spark discharge focused drill provided with one pulse forming line or a number of pulse forming lines. The pulse forming line is connected to an array of electrodes which would form a spark array. One of the electrodes of each of the array is connected to the high voltage side of the pulse forming line and the other electrodes are at ground potential. When discharged in a liquid, these electrodes produce intense focused shock waves that can pulverize or fracture rock. By delaying the firing of each group of electrodes, the drill can be steered within the earth. Power can be fed to the pulse forming line either downhole or from the surface area. A high voltage source, such as a Marx generator, is suitable for pulse charging the lines.

  19. sensor electrodes

    NASA Astrophysics Data System (ADS)

    Zhang, Zhiqiang; Ma, Congcong; He, Lian; Zhu, Shijin; Hao, Xiaodong; Xie, Wanyi; Zhang, Wei; Zhang, Yuxin

    2014-11-01

    In this work, an ultrafast and facile method is developed to synthesize Au(I)-dodecanethiolate nanotubes (Au(I)NTs) with the assistance of glycyl-glycyl-glycine (G-G-G). Transmission electron microscopy (TEM) images reveal that the as-prepared Au(I)NTs can be obtained in a 2-h reaction instead of a previous 24-h reaction and are uniform with a hollow structure and smooth surface by virtue of the G-G-G peptide tubular template. According to structural analysis, a possible preparative mechanism is proposed that the G-G-G peptide could help to curl into tube-like morphology in alkaline situation spontaneously to accelerate the formation of Au(I)NTs. Meanwhile, PVDF-stabilized Au(I)NT-modified glassy carbon electrodes present their promising potential for Hg2+ detection.

  20. Electrode migration after cochlear implant surgery: more common than expected?

    PubMed

    Dietz, Aarno; Wennström, Minna; Lehtimäki, Antti; Löppönen, Heikki; Valtonen, Hannu

    2016-06-01

    The overall complication rate of cochlear implant surgery is low and so-called electrode failures (electrode migration, misplacement, etc.,) account for only a minority of all complications. The aim of this study was to explore the prevalence of electrode migration as the cause for increased impedance values and non-auditory stimulation in the basal channels. Within the scope of a quality control process, the cochlear implant database of the Kuopio University Hospital (Finland) was reviewed. Patients with gradual elevation of impedance values and/or non-auditory stimulation of the basal electrode channels were re-examined and cone-beam computed tomography was administered. There were 162 cochlear implant recipients and 201 implanted devices registered in the database. A total of 18 patients (18 devices) were identified having significantly increased impedance values or non-auditory stimulation of the basal electrodes. Cone-beam computed tomography revealed extra-cochlear electrodes in 12 of these patients due to the migration of the electrode array. All extruded electrodes were lateral wall electrodes, i.e., straight electrode arrays (Cochlear CI422 and Med-El devices). The most common feature of electrode migration was the gradual increase of the impedance values in the basal electrodes, even though telemetry could also be unsuspicious. Electrode migration after cochlear implant surgery may be more common than previously reported. At surgery, special attention should be paid to the reliable fixation of the electrode array. This study underlines the importance of postoperative imaging after cochlear implant surgery. PMID:26164294

  1. Kokkos Array

    Energy Science and Technology Software Center (ESTSC)

    2012-09-12

    The Kokkos Array library implements shared-memory array data structures and parallel task dispatch interfaces for data-parallel computational kernels that are performance-portable to multicore-CPU and manycore-accelerator (e.g., GPGPU) devices.

  2. An Integrated ISFET Sensor Array

    PubMed Central

    Nakazato, Kazuo

    2009-01-01

    A monolithically integrated ISFET sensor array and interface circuit are described. A new high-density, low-power source-drain follower was developed for the sensor array. ISFETs were formed by depositing Au/Ti extended-gate electrodes on standard MOSFETs, then thin silicon nitride layers using catalytic chemical vapor deposition and/or SU-8 protective layers were formed on the extended-gate electrodes. Applications for the array include: (1) pH detection by statistical distribution observing time and space fluctuations; (2) DNA detection using thiol-modified or silane-coupled oligonucleotides; (3) bio-image sensing by converting photons to electrons using Photosystem I of Thermosynechococcus elongatus, and sensing the converted electric charges by ISFETs. PMID:22291539

  3. Systolic arrays

    SciTech Connect

    Moore, W.R.; McCabe, A.P.H.; Vrquhart, R.B.

    1987-01-01

    Selected Contents of this book are: Efficient Systolic Arrays for the Solution of Toeplitz Systems, The Derivation and Utilization of Bit Level Systolic Array Architectures, an Efficient Systolic Array for Distance Computation Required in a Video-Codec Based Motion-Detection, On Realizations of Least-Squares Estimation and Kalman Filtering by Systolic Arrays, and Comparison of Systolic and SIMD Architectures for Computer Vision Computations.

  4. Nanocylinder arrays

    DOEpatents

    Tuominen, Mark; Schotter, Joerg; Thurn-Albrecht, Thomas; Russell, Thomas P.

    2007-03-13

    Pathways to rapid and reliable fabrication of nanocylinder arrays are provided. Simple methods are described for the production of well-ordered arrays of nanopores, nanowires, and other materials. This is accomplished by orienting copolymer films and removing a component from the film to produce nanopores, that in turn, can be filled with materials to produce the arrays. The resulting arrays can be used to produce nanoscale media, devices, and systems.

  5. Nanocylinder arrays

    DOEpatents

    Tuominen, Mark; Schotter, Joerg; Thurn-Albrecht, Thomas; Russell, Thomas P.

    2009-08-11

    Pathways to rapid and reliable fabrication of nanocylinder arrays are provided. Simple methods are described for the production of well-ordered arrays of nanopores, nanowires, and other materials. This is accomplished by orienting copolymer films and removing a component from the film to produce nanopores, that in turn, can be filled with materials to produce the arrays. The resulting arrays can be used to produce nanoscale media, devices, and systems.

  6. Extraordinary enhancement of porphyrin photocurrent utilizing plasmonic silver arrays.

    PubMed

    Sugawa, Kosuke; Uchida, Koji; Takeshima, Naoto; Jin, Shota; Tsunenari, Natsumi; Takeda, Hideyuki; Kida, Yuki; Akiyama, Tsuyoshi; Otsuki, Joe; Takase, Kouichi; Yamada, Sunao

    2016-08-25

    We demonstrate up to ∼630-fold enhancement of the photocurrent from a porphyrin monolayer on a plasmonic Ag-array electrode showing plasmon absorption in the Q-band region relative to that on a planar Ag electrode. The photocurrent obtained by the Q-band excitation in the plasmonic electrodes even exceeded that obtained by the Soret-band excitation in a normal, nonplasmonic electrode. PMID:27420651

  7. Neonatal Auditory Brainstem Responses Recorded from Four Electrode Montages.

    ERIC Educational Resources Information Center

    Stuart, Andrew; And Others

    1996-01-01

    Simultaneous auditory brainstem responses (ABRs) to click stimuli at 30 and 60 decibels were recorded from 16 full-term neonates with 4 different electrode arrays. Results indicated that ABR waveforms were morphologically similar to those recorded in adults. Waveform expression was variable with different electrode recording montages. (Author/DB)

  8. resterilizable electrode for electrosurgery

    NASA Technical Reports Server (NTRS)

    Engstrom, E. R.; Houge, J. C.

    1979-01-01

    Required properties of flexibility, electrical conductivity, tensile strength, and tear resistance of electrosurgical electrodes is retained through utilization of flexible-polymer/conductive particle composites for electrodes.

  9. A comparative study of supercapacitive performances of nickel cobalt layered double hydroxides coated on ZnO nanostructured arrays on textile fibre as electrodes for wearable energy storage devices

    NASA Astrophysics Data System (ADS)

    Trang, Nguyen Thi Hong; Ngoc, Huynh Van; Lingappan, Niranjanmurthi; Kang, Dae Joon

    2014-01-01

    We demonstrated an efficient method for the fabrication of novel, flexible electrodes based on ZnO nanoflakes and nickel-cobalt layered double hydroxides (denoted as ZnONF/NiCoLDH) as a core-shell nanostructure on textile substrates for wearable energy storage devices. NiCoLDH coated ZnO nanowire (denoted as ZnONW/NiCoLDH) flexible electrodes are also prepared for comparison. As an electrode for supercapacitors, ZnONF/NiCoLDH exhibits a high specific capacitance of 1624 F g-1, which is nearly 1.6 times greater than ZnONW/NiCoLDH counterparts. It also shows a maximum energy density of 48.32 W h kg-1 at a power density of 27.53 kW kg-1, and an excellent cycling stability with capacitance retention of 94% and a Coulombic efficiency of 93% over 2000 cycles. We believe that the superior performance of the ZnONF/NiCoLDH hybrids is due primarily to the large surface area of the nanoflake structure and the open spaces between nanoflakes, both of which provide a large space for the deposition of NiCoLDH, resulting in reduced internal resistance and improved capacitance performance. Our results are significant for the development of electrode materials for high-performance wearable energy storage devices.We demonstrated an efficient method for the fabrication of novel, flexible electrodes based on ZnO nanoflakes and nickel-cobalt layered double hydroxides (denoted as ZnONF/NiCoLDH) as a core-shell nanostructure on textile substrates for wearable energy storage devices. NiCoLDH coated ZnO nanowire (denoted as ZnONW/NiCoLDH) flexible electrodes are also prepared for comparison. As an electrode for supercapacitors, ZnONF/NiCoLDH exhibits a high specific capacitance of 1624 F g-1, which is nearly 1.6 times greater than ZnONW/NiCoLDH counterparts. It also shows a maximum energy density of 48.32 W h kg-1 at a power density of 27.53 kW kg-1, and an excellent cycling stability with capacitance retention of 94% and a Coulombic efficiency of 93% over 2000 cycles. We believe that the

  10. Bioanalysis with Potentiometric Membrane Electrodes.

    ERIC Educational Resources Information Center

    Rechnitz, G. A.

    1982-01-01

    Discusses major themes and interrelationships common to bioselective potentiometric membrane electrodes including the nature of bioselective electrodes, applications, and future prospects. Includes tables on traditional ion-selective membrane electrodes, nontraditional electrodes, and typical biocatalytic potentiometric electrodes. (Author/JN)

  11. The in-capillary DPPH-capillary electrophoresis-the diode array detector combined with reversed-electrode polarity stacking mode for screening and quantifying major antioxidants in Cuscuta chinensis Lam.

    PubMed

    Liu, Jiao; Tian, Ji; Li, Jin; Azietaku, John Teye; Zhang, Bo-Li; Gao, Xiu-Mei; Chang, Yan-Xu

    2016-07-01

    An in-capillary 2, 2-diphenyl-1-picrylhydrazyl (DPPH)-CE-the DAD (in-capillary DPPH-CE-DAD) combined with reversed-electrode polarity stacking mode has been developed to screen and quantify the active antioxidant components of Cuscuta chinensis Lam. The operation parameters were optimized with regard to the pH and concentration of buffer solution, SDS, β-CDs, organic modifier, as well as separation voltage and temperature. Six antioxidants including chlorogenic acid, p-coumaric acid, rutin, hyperin, isoquercitrin, and astragalin were screened and the total antioxidant activity of the complex matrix was successfully evaluated based on the decreased peak area of DPPH by the established DPPH-CE-DAD method. Sensitivity was enhanced under reversed-electrode polarity stacking mode and 10- to 31-fold of magnitude improvement in detection sensitivity for each analyte was attained. The results demonstrated that the newly established in-capillary DPPH-CE-DAD method combined with reversed-electrode polarity stacking mode could integrate sample concentration, the oxidizing reaction, separation, and detection into one capillary to fully automate the system. It was considered a suitable technique for the separation, screening, and determination of trace antioxidants in natural products. PMID:26955793

  12. Synthesis, characterization and application of electrode materials

    SciTech Connect

    He, L.

    1995-07-07

    It has been known that significant advances in electrochemistry really depend on improvements in the sensitivity, selectivity, convenience, and/or economy of working electrodes, especially through the development of new working electrode materials. The advancement of solid state chemistry and materials science makes it possible to provide the materials which may be required as satisfactory electrode materials. The combination of solid state techniques with electrochemistry expands the applications of solid state materials and leads to the improvement of electrocatalysis. The study of Ru-Ti{sub 4}O{sub 7} and Pt-Ti{sub 4}O{sub 7} microelectrode arrays as introduced in paper 1 and paper 4, respectively, focuses on their synthesis and characterization. The synthesis is described by high temperature techniques for Ru or Pt microelectrode arrays within a conductive Ti{sub 4}O{sub 7} ceramic matrix. The characterization is based on the data obtained by x-ray diffractometry, scanning electron microscopy, voltammetry and amperometry. These microelectrode arrays show significant enhancement in current densities in comparison to solid Ru and Pt electrodes. Electrocatalysis at pyrochlore oxide Bi{sub 2}Ru{sub 2}O{sub 7.3} and Bi{sub 2}Ir{sub 2}O{sub 7} electrodes are described in paper 2 and paper 3, respectively. Details are reported for the synthesis and characterization of composite Bi{sub 2}Ru{sub 2}O{sub 7.3} electrodes. Voltammetric data are examined for evidence that oxidation can occur with transfer of oxygen to the oxidation products in the potential region corresponding to anodic discharge of H{sub 2}O with simultaneous evolution of O{sub 2}. Paper 3 includes electrocatalytic activities of composite Bi{sub 2}Ir{sub 2}O{sub 7} disk electrodes for the oxidation of I{sup -} and the reduction of IO{sub 3}{sup -}.

  13. Ion-Selective Electrodes.

    ERIC Educational Resources Information Center

    Arnold, Mark A.; Meyerhoff, Mark E.

    1984-01-01

    Literature on ion-selective electrodes (ISEs) is reviewed in seven sections: books, conferences, reviews; potentiometric membrane electrodes; glass and solid-state membrane electrodes; liquid and polymer membrane ISEs; coated wire electrodes, ion-selective field effect transistors, and microelectrodes; gas sensors and selective bioelectrode…

  14. Fundamental electrode kinetics

    NASA Technical Reports Server (NTRS)

    Elder, J. P.

    1968-01-01

    Report presents the fundamentals of electrode kinetics and the methods used in evaluating the characteristic parameters of rapid-charge transfer processes at electrode-electrolyte interfaces. The concept of electrode kinetics is outlined, followed by the principles underlying the experimental techniques for the investigation of electrode kinetics.

  15. Diagnostics for the Biased Electrode Experiment on NSTX

    SciTech Connect

    A.L. Roquemore, S.J. Zweben, C.E. Bush, R. Kaita, R. J. Marsalsa, and R.J. Maqueda

    2009-03-20

    A linear array of four small biased electrodes was installed in NSTX in an attempt to control the width of the scrape-off layer (SOL) by creating a strong local poloidal electric field. The set of electrodes were separated poloidally by a 1 cm gap between electrodes and were located slightly below the midplane of NSTX, 1 cm behind the RF antenna and oriented so that each electrode is facing approximately normal to the magnetic field. Each electrode can be independently biased to ±100 volts. Present power supplies limit the current on two electrodes to 30 amps the other two to 10 amps each. The effect of local biasing was measured with a set of Langmuir probes placed between the electrodes and another set extending radially outward from the electrodes, and also by the gas puff imaging diagnostic (GPI) located 1 m away along the magnetic field lines intersecting the electrodes. Two fast cameras were also aimed directly at the electrode array. The hardware and controls of the biasing experiment will be presented and the initial effects on local plasma parameters will be discussed.

  16. A flat laser array aperture

    NASA Astrophysics Data System (ADS)

    Papadakis, Stergios J.; Ricciardi, Gerald F.; Gross, Michael C.; Krill, Jerry A.

    2010-04-01

    We describe a design concept for a flat (or conformal) thin-plate laser phased-array aperture. The aperture consists of a substrate supporting a grid of single-mode optical waveguides fabricated from a linear electro-optic material. The waveguides are coupled to a single laser source or detector. An arrangement of electrodes provides for two-dimensional beam steering by controlling the phase of the light entering the grid. The electrodes can also be modulated to simultaneously provide atmospheric turbulence modulation for long-range free-space optical communication. An approach for fabrication is also outlined.

  17. High power density fuel cell comprising an array of microchannels

    SciTech Connect

    Morse, Jeffrey D.; Upadhye, Ravindra S.; Spadaccini, Christopher M.; Park, Hyung Gyu

    2013-10-15

    A fuel cell according to one embodiment includes a porous electrolyte support structure defining an array of microchannels, the microchannels including fuel and oxidant microchannels; fuel electrodes formed along some of the microchannels; and oxidant electrodes formed along other of the microchannels. A method of making a fuel cell according to one embodiment includes forming an array of walls defining microchannels therebetween using at least one of molding, stamping, extrusion, injection and electrodeposition; processing the walls to make the walls porous, thereby creating a porous electrolyte support structure; forming anode electrodes along some of the microchannels; and forming cathode electrodes along other of the microchannels. Additional embodiments are also disclosed.

  18. Variability of electrode positions using electrode caps.

    PubMed

    Atcherson, Samuel R; Gould, Herbert Jay; Pousson, Monique A; Prout, Tina M

    2007-01-01

    We investigated the variability of electrode positions for a multi-channel, custom electrode cap placed onto participants' heads without taking scalp measurements. The electrode positions were digitized in a three-dimensional space for 10 young adult participants on three separate occasions. Positional variability was determined for 15 selected electrodes within the three-dimensional preauricular-nasion (PAN) coordinate system and from this system, angular coordinate variability was also determined. The standard deviations of the 15 selected electrodes ranged from 3.0 to 12.7 mm in the PAN system. These data resulted in a variability of 2.0 degrees to 10.4 degrees among the angular coordinates. The measurements indicated slightly greater variability of electrode positions compared to studies when electrodes were placed using scalp measurements. The implication of this study is that the use of electrode caps may not be appropriate when electroencephalographic (EEG) or evoked potential (EP) techniques depend on accurate electrode placement. Additionally, if a longitudinal study is performed, electrode locations should be checked to ensure that they conform with previous sessions. PMID:17929157

  19. HSPES membrane electrode assembly

    NASA Technical Reports Server (NTRS)

    Kindler, Andrew (Inventor); Yen, Shiao-Ping (Inventor)

    2000-01-01

    An improved fuel cell electrode, as well as fuel cells and membrane electrode assemblies that include such an electrode, in which the electrode includes a backing layer having a sintered layer thereon, and a non-sintered free-catalyst layer. The invention also features a method of forming the electrode by sintering a backing material with a catalyst material and then applying a free-catalyst layer.

  20. Using a cut paste method to prepare a carbon nanotube fur electrode

    NASA Astrophysics Data System (ADS)

    Zhang, H.; Cao, G. P.; Yang, Y. S.

    2007-05-01

    We describe and realize an aligned carbon nanotube array based 'carbon nanotube fur (CNTF)' electrode. We removed an 800 µm long aligned carbon nanotube array from the silica substrate, and then pasted the array on a nickel foam current collector to obtain a CNTF electrode. CNTF's characteristics and electrochemical properties were studied systemically in this paper. The cut-paste method is simple, and does not damage the microstructure of the aligned carbon nanotube array. The CNTF electrode obtained a specific capacitance of 14.1 F g-1 and excellent rate capability.

  1. Nanoelectrode array formation by electrolytic nanoparticle impacts

    NASA Astrophysics Data System (ADS)

    Bartlett, T. R.; Holter, J.; Young, N.; Compton, R. G.

    2016-07-01

    We report the fabrication of functional nanoelectrode arrays by the electrolysis of AgBr nanoparticles (NPs) impacting on a glassy carbon electrode from suspension in aqueous solution. The impacted NPs result in Ag NP deposits of similar size to the originating NP, with the coverage of these arrays easily controlled by the time of the deposition step. The NPs constituting the array are deposited randomly across the surface with little aggregation or agglomeration. The fabricated arrays are themselves electrochemically active, mediating the reduction of hydrogen peroxide, H2O2.

  2. Nanoelectrode array formation by electrolytic nanoparticle impacts.

    PubMed

    Bartlett, T R; Holter, J; Young, N; Compton, R G

    2016-07-21

    We report the fabrication of functional nanoelectrode arrays by the electrolysis of AgBr nanoparticles (NPs) impacting on a glassy carbon electrode from suspension in aqueous solution. The impacted NPs result in Ag NP deposits of similar size to the originating NP, with the coverage of these arrays easily controlled by the time of the deposition step. The NPs constituting the array are deposited randomly across the surface with little aggregation or agglomeration. The fabricated arrays are themselves electrochemically active, mediating the reduction of hydrogen peroxide, H2O2. PMID:26758943

  3. MnO 2 nanotube and nanowire arrays by electrochemical deposition for supercapacitors

    NASA Astrophysics Data System (ADS)

    Xia, Hui; Feng, Jinkui; Wang, Hailong; Lai, Man On; Lu, Li

    Highly ordered MnO 2 nanotube and nanowire arrays are successfully synthesized via a electrochemical deposition technique using porous alumina templates. The morphologies and microstructures of the MnO 2 nanotube and nanowire arrays are investigated by field emission scanning electron microscopy and transmission electron microscopy. Electrochemical characterization demonstrates that the MnO 2 nanotube array electrode has superior capacitive behaviour to that of the MnO 2 nanowire array electrode. In addition to high specific capacitance, the MnO 2 nanotube array electrode also exhibits good rate capability and good cycling stability, which makes it promising candidate for supercapacitors.

  4. High frequency reference electrode

    DOEpatents

    Kronberg, J.W.

    1994-05-31

    A high frequency reference electrode for electrochemical experiments comprises a mercury-calomel or silver-silver chloride reference electrode with a layer of platinum around it and a layer of a chemically and electrically resistant material such as TEFLON around the platinum covering all but a small ring or halo' at the tip of the reference electrode, adjacent to the active portion of the reference electrode. The voltage output of the platinum layer, which serves as a redox electrode, and that of the reference electrode are coupled by a capacitor or a set of capacitors and the coupled output transmitted to a standard laboratory potentiostat. The platinum may be applied by thermal decomposition to the surface of the reference electrode. The electrode provides superior high-frequency response over conventional electrodes. 4 figs.

  5. Controlled porosity in electrodes

    SciTech Connect

    Chiang, Yet-Ming; Bae, Chang-Jun; Halloran, John William; Fu, Qiang; Tomsia, Antoni P.; Erdonmez, Can K.

    2015-06-23

    Porous electrodes in which the porosity has a low tortuosity are generally provided. In some embodiments, the porous electrodes can be designed to be filled with electrolyte and used in batteries, and can include low tortuosity in the primary direction of ion transport during charge and discharge of the battery. In some embodiments, the electrodes can have a high volume fraction of electrode active material (i.e., low porosity). The attributes outlined above can allow the electrodes to be fabricated with a higher energy density, higher capacity per unit area of electrode (mAh/cm.sup.2), and greater thickness than comparable electrodes while still providing high utilization of the active material in the battery during use. Accordingly, the electrodes can be used to produce batteries with high energy densities, high power, or both compared to batteries using electrodes of conventional design with relatively highly tortuous pores.

  6. High frequency reference electrode

    DOEpatents

    Kronberg, James W.

    1994-01-01

    A high frequency reference electrode for electrochemical experiments comprises a mercury-calomel or silver-silver chloride reference electrode with a layer of platinum around it and a layer of a chemically and electrically resistant material such as TEFLON around the platinum covering all but a small ring or "halo" at the tip of the reference electrode, adjacent to the active portion of the reference electrode. The voltage output of the platinum layer, which serves as a redox electrode, and that of the reference electrode are coupled by a capacitor or a set of capacitors and the coupled output transmitted to a standard laboratory potentiostat. The platinum may be applied by thermal decomposition to the surface of the reference electrode. The electrode provides superior high-frequency response over conventional electrodes.

  7. Phase-locked laser array

    NASA Technical Reports Server (NTRS)

    Botez, Dan (Inventor)

    1987-01-01

    A phase-locked laser array comprises a body of semiconductor material having means for defining a plurality of substantially parallel lasing zones which are spaced an effective distance apart so that the modes of the adjacent lasing zones are phase-locked to one another. One of the array electrodes comprises a plurality of electrical contacts to the body between the lasing zones. These contacts provide an enhanced current density profile and thus an increase in the gain in the regions between the lasing zones so that zero degree phase-shift operation between adjacent lasing zones is achievable.

  8. On Using Residual Voltage to Estimate Electrode Model Parameters for Damage Detection

    PubMed Central

    Krishnan, Ashwati; Kelly, Shawn K.

    2016-01-01

    Current technology has enabled a significant increase in the number of electrodes for electrical stimulation. For large arrays of electrodes, it becomes increasingly difficult to monitor and detect failures at the stimulation site. In this paper, we propose the idea that the residual voltage from a biphasic electrical stimulation pulse can serve to recognize damage at the electrode-tissue interface. We use a simple switch circuit approach to estimate the relaxation time constant of the electrode model, which essentially models the residual voltage in biphasic electrical stimulation, and compare it with standard electrode characterization techniques. Out of 15 electrodes in a polyimide-based SIROF array, our approach highlights 3 damaged electrodes, consistent with measurements made using cyclic voltammetry and electrode impedance spectroscopy.

  9. High voltage load resistor array

    DOEpatents

    Lehmann, Monty Ray

    2005-01-18

    A high voltage resistor comprising an array of a plurality of parallel electrically connected resistor elements each containing a resistive solution, attached at each end thereof to an end plate, and about the circumference of each of the end plates, a corona reduction ring. Each of the resistor elements comprises an insulating tube having an electrode inserted into each end thereof and held in position by one or more hose clamps about the outer periphery of the insulating tube. According to a preferred embodiment, the electrode is fabricated from stainless steel and has a mushroom shape at one end, that inserted into the tube, and a flat end for engagement with the end plates that provides connection of the resistor array and with a load.

  10. High performance cermet electrodes

    DOEpatents

    Isenberg, Arnold O.; Zymboly, Gregory E.

    1986-01-01

    Disclosed is a method of increasing the operating cell voltage of a solid oxide electrochemical cell having metal electrode particles in contact with an oxygen-transporting ceramic electrolyte. The metal electrode is heated with the cell, and oxygen is passed through the oxygen-transporting ceramic electrolyte to the surface of the metal electrode particles so that the metal electrode particles are oxidized to form a metal oxide layer between the metal electrode particles and the electrolyte. The metal oxide layer is then reduced to form porous metal between the metal electrode particles and the ceramic electrolyte.

  11. Spatially extended atmospheric plasma arrays

    NASA Astrophysics Data System (ADS)

    Cao, Z.; Nie, Q.; Bayliss, D. L.; Walsh, J. L.; Ren, C. S.; Wang, D. Z.; Kong, M. G.

    2010-04-01

    This paper reports a systematic study of spatially extended atmospheric plasma (SEAP) arrays employing many parallel plasma jets packed densely and arranged in an honeycomb configuration. The work is motivated by the challenge of using inherently small atmospheric plasmas to address many large-scale processing applications including plasma medicine. The first part of the study considers a capillary-ring electrode configuration as the elemental jet with which to construct a 2D SEAP array. It is shown that its plasma dynamics is characterized by strong interaction between two plasmas initially generated near the two electrodes. Its plume length increases considerably when the plasma evolves into a high-current continuous mode from the usual bullet mode. Its electron density is estimated to be at the order of 3.7 × 1012 cm-3. The second part of the study considers 2D SEAP arrays constructed from parallelization of identical capillary-ring plasma jets with very high jet density of 0.47-0.6. Strong jet-jet interactions of a 7-jet 2D array are found to depend on the excitation frequency, and are effectively mitigated with the jet-array structure that acts as an effective ballast. The impact range of the reaction chemistry of the array exceeds considerably the cross-sectional dimension of the array itself, and the physical reach of reactive species generated by any single jet exceeds significantly the jet-jet distance. As a result, the jet array can treat a large sample surface without relative sample-array movement. A 37-channel SEAP array is used to indicate the scalability with an impact range of up to 48.6 mm in diameter, a step change in capability from previously reported SEAP arrays. 2D SEAP arrays represent one of few current options as large-scale low-temperature atmospheric plasma technologies with distinct capability of directed delivery of reactive species and effective control of the jet-jet and jet-sample interactions.

  12. Pitch ranking, electrode discrimination, and physiological spread-of-excitation using Cochlear's dual-electrode mode.

    PubMed

    Goehring, Jenny L; Neff, Donna L; Baudhuin, Jacquelyn L; Hughes, Michelle L

    2014-08-01

    This study compared pitch ranking, electrode discrimination, and electrically evoked compound action potential (ECAP) spatial excitation patterns for adjacent physical electrodes (PEs) and the corresponding dual electrodes (DEs) for newer-generation Cochlear devices (Cochlear Ltd., Macquarie, New South Wales, Australia). The first goal was to determine whether pitch ranking and electrode discrimination yield similar outcomes for PEs and DEs. The second goal was to determine if the amount of spatial separation among ECAP excitation patterns (separation index, Σ) between adjacent PEs and the PE-DE pairs can predict performance on the psychophysical tasks. Using non-adaptive procedures, 13 subjects completed pitch ranking and electrode discrimination for adjacent PEs and the corresponding PE-DE pairs (DE versus each flanking PE) from the basal, middle, and apical electrode regions. Analysis of d' scores indicated that pitch-ranking and electrode-discrimination scores were not significantly different, but rather produced similar levels of performance. As expected, accuracy was significantly better for the PE-PE comparison than either PE-DE comparison. Correlations of the psychophysical versus ECAP Σ measures were positive; however, not all test/region correlations were significant across the array. Thus, the ECAP separation index is not sensitive enough to predict performance on behavioral tasks of pitch ranking or electrode discrimination for adjacent PEs or corresponding DEs. PMID:25096106

  13. Diffusion-bonded electrodes for chronic neural stimulation.

    PubMed

    Shah, Kedar G; Lee, Kye Young; Tolosa, Vanessa; Tooker, Angela; Felix, Sarah; Pannu, Satinderpall

    2014-01-01

    We report a novel method to fabricate chronic neural interfaces with the intent to combine the reliability and lifetime of bulk metal electrodes, with the miniaturization and mechanical flexibility of thin-film polymer microelectrode arrays. 10 μm thick platinum discs were laser cut from a foil into the shape of individual electrodes, and coated with gold on the backside. The discs were bonded to a microelectrode array with gold bond pads via gold-gold inter-diffusion using a flipchip bonder. Electrode bonding and adhesion was characterized using mechanical shear testing and electrical testing. Electrode performance was characterized in vitro using electrochemical impedance spectroscopy and cyclic voltammetry. Biphasic electrical pulsing experiments were conducted on the bonded electrodes to study degradation of the electrode; the preliminary results show that the electrodes can withstand at least 4,900 million pulses with no adverse electrochemical or visual degradation. Overall, this is a promising new method for fabricating chronic neural electrodes for stimulation or recording that combines the reliability of commercial bulk electrodes with the miniaturization and versatility of microfabricated technologies. PMID:25569992

  14. Integrated uncooled array IR sensors

    NASA Astrophysics Data System (ADS)

    Pevtsov, Eugeny P.; Elkin, Eugeny G.; Pospelova, Marina A.

    1997-08-01

    Technologies enabling low-dissipation designs for uncooled array IR sensors are offered. The technique involves the etching of special buffer layers from under a 1-micrometers membrane followed by deposition of an IR-sensitive film and electrode structure. The electrical and physical properties of plumbum-zirconate-titanate, barium titanate, tetraaminodiphenyl, polyvinylidene fluoride pyroelectric films are compared. A circuit for sensing pyroelectric signals in a CCD is considered.

  15. Interagency arraying

    NASA Astrophysics Data System (ADS)

    Cox, Henry G.

    Activities performed to match ground aperture requirements for the Neptune encounter in August 1989 with the expected capabilities of the JPL Deep Space Network (DSN) are discussed. Ground aperture requirements, DSN capabilities, and the capabilities of other agencies are reviewed. The design and configurations of the receiver subsystem, combiner subsystem, monitor and control subsystem, recording subsystem, and supporting subsystems are described. The implementation of the Very Large Array-Goldstone Telemetry Array is discussed, and the differences involved with the Parkes-Canberra Telemetry Array implementation are highlighted. The operational concept is addressed.

  16. Highly sensitive detection of nitroaromatic explosives at discrete nanowire arrays.

    PubMed

    Barry, Sean; Dawson, Karen; Correa, Elon; Goodacre, Royston; O'Riordan, Alan

    2013-01-01

    We show a photolithography technique that permits gold nanowire array electrodes to be routinely fabricated at reasonable cost. Nanowire electrode arrays offer the potential for enhancements in electroanalysis such as increased signal-to-noise ratio and increased sensitivity while also allowing quantitative detection at much lower concentrations. We explore application of nanowire array electrodes to the detection of different nitroaromatic species. Characteristic reduction peaks of nitro groups are not observed at nanowire array electrodes using sweep voltammetric methods. By contrast, clear and well-defined reduction peaks are resolved using potential step square wave voltammetry. A Principle Component Analysis technique is employed to discriminate between nitroaromatic species including structural isomers of DNT. The analysis indicates that all compounds are successfully discriminated by unsupervised cluster analysis. Finally, the magnitude of the reduction peak at -671 mV for different concentrations of TNT exhibited excellent linearity with increasing concentrations enabling sub-150 ng mL(-1) limits of detection. PMID:24466670

  17. Corneal-shaping electrode

    DOEpatents

    Doss, James D.; Hutson, Richard L.

    1982-01-01

    The disclosure relates to a circulating saline electrode for changing corneal shape in eyes. The electrode comprises a tubular nonconductive electrode housing having an annular expanded base which has a surface substantially matched to a subject corneal surface. A tubular conductive electrode connected to a radiofrequency generating source is disposed within the electrode housing and longitudinally aligned therewith. The electrode has a generally hemispherical head having at least one orifice. Saline solution is circulated through the apparatus and over the cornea to cool the corneal surface while radiofrequency electric current emitted from the electrode flows therefrom through the cornea to a second electrode, on the rear of the head. This current heats the deep corneal stroma and thereby effects corneal reshaping as a biological response to the heat.

  18. Improved biomedical electrode

    NASA Technical Reports Server (NTRS)

    Frost, J. D., Jr.

    1972-01-01

    Newly designed electrode is prefilled, disposable, electrolyte-saturated spong. New design permits longe periods of storage without deterioration, and readiness in matter of seconds. Electrodes supply signals for electroencephalogram, electro-oculogram, and electrocardiogram.

  19. Compartmented electrode structure

    DOEpatents

    Vissers, Donald R.; Shimotake, Hiroshi; Gay, Eddie C.; Martino, Fredric J.

    1977-06-14

    Electrodes for secondary electrochemical cells are provided with compartments for containing particles of the electrode reactant. The compartments are defined by partitions that are generally impenetrable to the particles of reactant and, in some instances, to the liquid electrolyte used in the cell. During cycling of the cell, reactant material initially loaded into a particular compartment is prevented from migrating and concentrating within the lower portion of the electrode or those portions of the electrode that exhibit reduced electrical resistance.

  20. Arrays of Coplanar Eletrode Microplasma Devices

    NASA Astrophysics Data System (ADS)

    Meng, L. G.; Xing, J. P.; Liang, Z. H.; Liu, C. L.; Lin, Z. J.

    We introduce a novel microplasma device with coplanar electrodes (Coplanar Eletrode Microplasma Devices, CEMPD). The microcavities of the proposed device compose of two coplanar electrodes instead of dielectric or single cathode, which can enhance the density of microcavities. The devices are fabricated by only one wet lithography process, which can simplify the fabrication processes and develop the fabrication uniformity. Two kinds of prototype have been fabricated, line array of CEMPD and arrays of CEMPD. The experiments show that the power loading of each microcavity could reach several kW cm-3. In neon, the luminance of the line array of CEMPD with 12 microcavities driven by AC sinusoidal voltage reaches 2500 cd m-2. The multidischarge phenomenon and a Pressure-Independent Point (PIP) in a group of current-voltage (I-V) curves for the line array of CEMPD have been investigated. The details of these phenomena should be investigated in detail.

  1. Enthalpy arrays

    NASA Astrophysics Data System (ADS)

    Torres, Francisco E.; Kuhn, Peter; de Bruyker, Dirk; Bell, Alan G.; Wolkin, Michal V.; Peeters, Eric; Williamson, James R.; Anderson, Gregory B.; Schmitz, Gregory P.; Recht, Michael I.; Schweizer, Sandra; Scott, Lincoln G.; Ho, Jackson H.; Elrod, Scott A.; Schultz, Peter G.; Lerner, Richard A.; Bruce, Richard H.

    2004-06-01

    We report the fabrication of enthalpy arrays and their use to detect molecular interactions, including protein-ligand binding, enzymatic turnover, and mitochondrial respiration. Enthalpy arrays provide a universal assay methodology with no need for specific assay development such as fluorescent labeling or immobilization of reagents, which can adversely affect the interaction. Microscale technology enables the fabrication of 96-detector enthalpy arrays on large substrates. The reduction in scale results in large decreases in both the sample quantity and the measurement time compared with conventional microcalorimetry. We demonstrate the utility of the enthalpy arrays by showing measurements for two protein-ligand binding interactions (RNase A + cytidine 2'-monophosphate and streptavidin + biotin), phosphorylation of glucose by hexokinase, and respiration of mitochondria in the presence of 2,4-dinitrophenol uncoupler.

  2. PEDOT polymer coatings facilitate smaller neural recording electrodes

    PubMed Central

    Ludwig, Kip A.; Langhals, Nicholas B.; Joseph, Mike D.; Richardson-Burns, Sarah M.; Hendricks, Jeffrey L.; Kipke, Daryl R.

    2012-01-01

    We investigated using poly(3,4-ethylenedioxythiophene) (PEDOT) to lower the impedance of small, gold recording electrodes with initial impedances outside of the effective recording range. Smaller electrode sites enable more densely packed arrays, increasing the number of input and output channels to and from the brain. Moreover, smaller electrode sizes promote smaller probe designs; decreasing the dimensions of the implanted probe has been demonstrated to decrease the inherent immune response, a known contributor to the failure of long-term implants. As expected, chronically implanted control electrodes were unable to record well-isolated unit activity, primarily as a result of a dramatically increased noise floor. Conversely, electrodes coated with PEDOT consistently recorded high-quality neural activity, and exhibited a much lower noise floor than controls. These results demonstrate that PEDOT coatings enable electrode designs 15 microns in diameter. PMID:21245527

  3. Electrostatic quadrupole array for focusing parallel beams of charged particles

    DOEpatents

    Brodowski, John

    1982-11-23

    An array of electrostatic quadrupoles, capable of providing strong electrostatic focusing simultaneously on multiple beams, is easily fabricated from a single array element comprising a support rod and multiple electrodes spaced at intervals along the rod. The rods are secured to four terminals which are isolated by only four insulators. This structure requires bias voltage to be supplied to only two terminals and eliminates the need for individual electrode bias and insulators, as well as increases life by eliminating beam plating of insulators.

  4. Dielectrophoresis device and method having nonuniform arrays for manipulating particles

    SciTech Connect

    Cummings, Eric B.; Fintschenko, Yolanda; Simmons, Blake A.

    2012-09-04

    Microfluidic devices according to embodiments of the present invention include an inlet port, an outlet port, and a channel or chamber having a non-uniform array of insulating features on one or more surfaces. Electrodes are provided for generation of a spatially non-uniform electric field across the array. A voltage source, which may be an A.C. and/or a D.C. voltage source may be coupled to the electrodes for the generation of the electric field.

  5. Insulated ECG electrodes

    NASA Technical Reports Server (NTRS)

    Portnoy, W. M.; David, R. M.

    1973-01-01

    Insulated, capacitively coupled electrode does not require electrolyte paste for attachment. Other features of electrode include wide range of nontoxic material that may be employed for dielectric because of sputtering technique used. Also, electrode size is reduced because there is no need for external compensating networks with FET operational amplifier.

  6. Longitudinal discharge laser electrodes

    DOEpatents

    Warner, B.E.; Miller, J.L.; Ault, E.R.

    1994-08-23

    The improved longitudinal discharge laser electrode with IR baffle includes an electrode made up of washers spaced along the laser axis in order to form inter-washer spaces for hollow cathode discharge to take place and for IR radiation to be trapped. Additional IR baffles can be placed between the electrode ann the window. 2 figs.

  7. Longitudinal discharge laser electrodes

    DOEpatents

    Warner, Bruce E.; Miller, John L.; Ault, Earl R.

    1994-01-01

    The improved longitudinal discharge laser electrode with IR baffle includes an electrode made up of washers spaced along the laser axis in order to form inter-washer spaces for hollow cathode discharge to take place and for IR radiation to be trapped. Additional IR baffles can be placed between the electrode ann the window.

  8. A Simple Hydrogen Electrode

    ERIC Educational Resources Information Center

    Eggen, Per-Odd

    2009-01-01

    This article describes the construction of an inexpensive, robust, and simple hydrogen electrode, as well as the use of this electrode to measure "standard" potentials. In the experiment described here the students can measure the reduction potentials of metal-metal ion pairs directly, without using a secondary reference electrode. Measurements…

  9. Near-electrode imager

    DOEpatents

    Rathke, Jerome W.; Klingler, Robert J.; Woelk, Klaus; Gerald, II, Rex E.

    2000-01-01

    An apparatus, near-electrode imager, for employing nuclear magnetic resonance imaging to provide in situ measurements of electrochemical properties of a sample as a function of distance from a working electrode. The near-electrode imager uses the radio frequency field gradient within a cylindrical toroid cavity resonator to provide high-resolution nuclear magnetic resonance spectral information on electrolyte materials.

  10. Fuel cell electrodes

    DOEpatents

    Strmcnik, Dusan; Cuesta, Angel; Stamenkovic, Vojislav; Markovic, Nenad

    2015-06-23

    A process includes patterning a surface of a platinum group metal-based electrode by contacting the electrode with an adsorbate to form a patterned platinum group metal-based electrode including platinum group metal sites blocked with adsorbate molecules and platinum group metal sites which are not blocked.

  11. Electrically conductive diamond electrodes

    DOEpatents

    Swain, Greg; Fischer, Anne ,; Bennett, Jason; Lowe, Michael

    2009-05-19

    An electrically conductive diamond electrode and process for preparation thereof is described. The electrode comprises diamond particles coated with electrically conductive doped diamond preferably by chemical vapor deposition which are held together with a binder. The electrodes are useful for oxidation reduction in gas, such as hydrogen generation by electrolysis.

  12. Microresonator electrode design

    DOEpatents

    Olsson, III, Roy H.; Wojciechowski, Kenneth; Branch, Darren W.

    2016-05-10

    A microresonator with an input electrode and an output electrode patterned thereon is described. The input electrode includes a series of stubs that are configured to isolate acoustic waves, such that the waves are not reflected into the microresonator. Such design results in reduction of spurious modes corresponding to the microresonator.

  13. Near-Electrode Imager

    SciTech Connect

    Rathke, Jerome W.; Klingler, Robert J.; Woelk, Klaus; Gerald, Rex E.,II

    1999-05-01

    An apparatus, near-electrode imager, for employing nuclear magnetic resonance imaging to provide in situ measurements of electrochemical properties of a sample as a function of distance from a working electrode. The near-electrode imager use the radio frequency field gradient within a cylindrical toroid cavity resonator to provide high-resolution nuclear magnetic resonance spectral information on electrolyte materials.

  14. Aerospace electrode line

    NASA Technical Reports Server (NTRS)

    Miller, L.

    1980-01-01

    A facility which produces electrodes for spacecraft power supplies is described. The electrode assembly procedures are discussed. A number of design features in the production process are reported including a batch operation mode and an independent equipment module design approach for transfering the electrode materials from process tank to process tank.

  15. Array tomography: production of arrays.

    PubMed

    Micheva, Kristina D; O'Rourke, Nancy; Busse, Brad; Smith, Stephen J

    2010-11-01

    Array tomography is a volumetric microscopy method based on physical serial sectioning. Ultrathin sections of a plastic-embedded tissue are cut using an ultramicrotome, bonded in an ordered array to a glass coverslip, stained as desired, and imaged. The resulting two-dimensional image tiles can then be reconstructed computationally into three-dimensional volume images for visualization and quantitative analysis. The minimal thickness of individual sections permits high-quality rapid staining and imaging, whereas the array format allows reliable and convenient section handling, staining, and automated imaging. Also, the physical stability of the arrays permits images to be acquired and registered from repeated cycles of staining, imaging, and stain elution, as well as from imaging using multiple modalities (e.g., fluorescence and electron microscopy). Array tomography makes it possible to visualize and quantify previously inaccessible features of tissue structure and molecular architecture. However, careful preparation of the tissue is essential for successful array tomography; these steps can be time consuming and require some practice to perfect. This protocol describes the sectioning of embedded tissues and the mounting of the serial arrays. The procedures require some familiarity with the techniques used for ultramicrotome sectioning for electron microscopy. PMID:21041397

  16. Array tomography: imaging stained arrays.

    PubMed

    Micheva, Kristina D; O'Rourke, Nancy; Busse, Brad; Smith, Stephen J

    2010-11-01

    Array tomography is a volumetric microscopy method based on physical serial sectioning. Ultrathin sections of a plastic-embedded tissue are cut using an ultramicrotome, bonded in an ordered array to a glass coverslip, stained as desired, and imaged. The resulting two-dimensional image tiles can then be reconstructed computationally into three-dimensional volume images for visualization and quantitative analysis. The minimal thickness of individual sections permits high-quality rapid staining and imaging, whereas the array format allows reliable and convenient section handling, staining, and automated imaging. Also, the physical stability of the arrays permits images to be acquired and registered from repeated cycles of staining, imaging, and stain elution, as well as from imaging using multiple modalities (e.g., fluorescence and electron microscopy). Array tomography makes it possible to visualize and quantify previously inaccessible features of tissue structure and molecular architecture. However, careful preparation of the tissue is essential for successful array tomography; these steps can be time-consuming and require some practice to perfect. In this protocol, tissue arrays are imaged using conventional wide-field fluorescence microscopy. Images can be captured manually or, with the appropriate software and hardware, the process can be automated. PMID:21041399

  17. Neurotoxicity testing using Microelectrode Arrays (MEAs): a growing trend

    EPA Science Inventory

    Microelectrode arrays (MEAs) are groups of extracellular electrodes that are 10-30 microns in diameter and can be utilized in vivo or in vitro. For in vitro uses, an MEA typically contains up to 64 electrodes and can be utilized to measure the activity of cells and tissues that a...

  18. Access resistance of stimulation electrodes as a function of electrode proximity to the retina

    NASA Astrophysics Data System (ADS)

    Majdi, Joseph A.; Minnikanti, Saugandhika; Peixoto, Nathalia; Agrawal, Anant; Cohen, Ethan D.

    2015-02-01

    Objective. Epiretinal prostheses seek to effectively stimulate the retina by positioning electrode arrays close to its surface so current pulses generate narrow retinal electric fields. Our objective was to evaluate the use of the electrical impedance of insulated platinum electrodes as a measure of the proximity of insulated platinum electrodes to the inner surface of the retina. Approach. We examined the impedance of platinum disk electrodes, 0.25 mm in diameter, insulated with two widths (0.8 and 1.6 mm outer diameter) of transparent fluoropolymer in a rabbit retinal eyecup preparation. Optical coherence tomography measured the electrode’s proximity to the retinal surface which was correlated with changes in the voltage waveform at the electrode. Electrode impedance changes during retinal deformation were also studied. Main results. When the 1.6 mm diameter insulated electrodes advanced towards the retinal surface from 1000 μm, their voltage step at current pulse onset increased, reflecting an access resistance increase of 3880 ± 630 Ω, with the 50% midpoint averaging 30 μm, while thin 0.8 mm insulated electrode advancement showed an access resistance increase 50% midpoint averaging 16 μm. Using impedance spectroscopy, electrode-retina proximity differences were seen in the 1.6 mm insulated electrode impedance modulus between 1 and 100 kHz and the waveform phase angle at 0.3-10 kHz, while thin 0.8 mm insulated electrode advancement produced smaller impedance modulus changes with retinal proximity between 3 and 100 kHz. These impedance changes with retinal proximity may reflect different sized zones of eye wall being coupled in series with the insulated platinum electrode. Significance. The proximity of stimulus electrodes to neural tissue in fluid-filled spaces can be estimated from access resistance changes in the stimulus pulse waveform. Because many prosthetic devices allow back telemetry communication of the stimulus electrode waveform, it is possible

  19. Programmable Aperture with MEMS Microshutter Arrays

    NASA Technical Reports Server (NTRS)

    Moseley, Samuel; Li, Mary; Kutyrev, Alexander; Kletetschka, Gunther; Fettig, Rainer

    2011-01-01

    A microshutter array (MSA) has been developed for use as an aperture array for multi-object selections in James Webb Space Telescope (JWST) technology. Light shields, molybdenum nitride (MoN) coating on shutters, and aluminum/aluminum oxide coatings on interior walls are put on each shutter for light leak prevention, and to enhance optical contrast. Individual shutters are patterned with a torsion flexure that permits shutters to open 90 deg. with a minimized mechanical stress concentration. The shutters are actuated magnetically, latched, and addressed electrostatically. Also, micromechanical features are tailored onto individual shutters to prevent stiction. An individual shutter consists of a torsion hinge, a shutter blade, a front electrode that is coated on the shutter blade, a backside electrode that is coated on the interior walls, and a magnetic cobalt-iron coating. The magnetic coating is patterned into stripes on microshutters so that shutters can respond to an external magnetic field for the magnetic actuation. A set of column electrodes is placed on top of shutters, and a set of row electrodes on sidewalls is underneath the shutters so that they can be electrostatically latched open. A linear permanent magnet is aligned with the shutter rows and is positioned above a flipped upside-down array, and sweeps across the array in a direction parallel to shutter columns. As the magnet sweeps across the array, sequential rows of shutters are rotated from their natural horizontal orientation to a vertical open position, where they approach vertical electrodes on the sidewalls. When the electrodes are biased with a sufficient electrostatic force to overcome the mechanical restoring force of torsion bars, shutters remain latched to vertical electrodes in their open state. When the bias is removed, or is insufficient, the shutters return to their horizontal, closed positions. To release a shutter, both the electrode on the shutter and the one on the back wall where

  20. Spark gap electrode erosion

    NASA Astrophysics Data System (ADS)

    Krompholz, H.; Kristiansen, M.

    1984-12-01

    The results of a one-year contract on electrode erosion phenomena are summarized. The arc voltage drop in a spark gap was measured for various electrode, gas, and pressure combinations. A previously developed model of self breakdown voltage distribution was extended. A jet model for electrode erosion was proposed and an experimental arrangement for testing the model was constructed. The effects of inhomogeneities and impurities in the electrodes were investigated. Some of the work described here is scheduled for completion in 1985 under a current grant (AFOSR 84-0032). The areas of investigation described here include: (1) Self breakdown voltage distributions; (2) Electrode erosion; (3) Spark gap voltage recovery.

  1. Negative electrode composition

    DOEpatents

    Kaun, Thomas D.; Chilenskas, Albert A.

    1982-01-01

    A secondary electrochemical cell and a negative electrode composition for use therewith comprising a positive electrode containing an active material of a chalcogen or a transiton metal chalcogenide, a negative electrode containing a lithium-aluminum alloy and an amount of a ternary alloy sufficient to provide at least about 5 percent overcharge capacity relative to a negative electrode solely of the lithium-aluminum alloy, the ternary alloy comprising lithium, aluminum, and iron or cobalt, and an electrolyte containing lithium ions in contact with both of the positive and the negative electrodes. The ternary alloy is present in the electrode in the range of from about 5 percent to about 50 percent by weight of the electrode composition and may include lithium-aluminum-nickel alloy in combination with either the ternary iron or cobalt alloys. A plurality of series connected cells having overcharge capacity can be equalized on the discharge side without expensive electrical equipment.

  2. High voltage solar array experiments

    NASA Technical Reports Server (NTRS)

    Kennerud, K. L.

    1974-01-01

    The interaction between the components of a high voltage solar array and a simulated space plasma is studied to obtain data for the design of a high voltage solar array capable of 15kW at 2 to 16kV. Testing was conducted in a vacuum chamber 1.5-m long by 1.5-m diameter having a plasma source which simulated the plasma conditions existing in earth orbit between 400 nautical miles and synchronous altitude. Test samples included solar array segments pinholes in insulation covering high voltage electrodes, and plain dielectric samples. Quantitative data are presented in the areas of plasma power losses, plasma and high voltage induced damage, and dielectric properties. Limitations of the investigation are described.

  3. Virtual electrode design for increasing spatial resolution in retinal prosthesis.

    PubMed

    Loizos, Kyle; Cela, Carlos; Marc, Robert; Lazzi, Gianluca

    2016-06-01

    Retinal prostheses systems are currently used to restore partial vision to patients blinded by degenerative diseases by electrically stimulating surviving retinal cells. To obtain likely maximum resolution, electrode size is minimised, allowing for a large quantity on an array and localised stimulation regions. Besides the small size leading to fabrication difficulties and higher electrochemical charge density, there are challenges associated with the number of drivers needed for a large electrode count as well as the strategies to deliver sufficient power to these drivers wirelessly. In hopes to increase electrode resolution while avoiding these issues, the authors propose a new 'virtual electrode' design to increase locations of likely stimulation. Passive metallisation strategically placed between disk electrodes, combined with alternating surrounding stimuli, channel current into a location between electrodes, producing a virtual stimulation site. A computational study was conducted to optimise the passive metal element geometry, quantify the expected current density output, and simulate retinal ganglion cell activity due to virtual electrode stimulation. Results show that this procedure leads to array geometry that focuses injected current and achieves retinal ganglion cell stimulation in a region beneath the 'virtual electrode,' creating an alternate stimulation site without additional drivers. PMID:27382477

  4. Normalized ion distribution function in expanding sheaths of 2D grid electrodes

    NASA Astrophysics Data System (ADS)

    Yi, Changho; Namkung, Won; Cho, Moohyun

    2016-04-01

    Ion distributions in expanding collisionless sheaths of two-dimensional (2D) grid electrodes were studied by using XOOPIC (particle-in-cell) simulations when short pulses of negative high-voltage were applied to electrodes immersed in plasmas. 2D grid electrodes consist of a periodic array of cylindrical electrodes, and the opening ratio of the grid electrodes is defined by the ratio of the spacing between cylindrical electrodes to the periodic length of the grid electrodes. In this paper, we introduce a normalized ion distribution function in normalized coordinates, and it is shown by simulation that the normalized ion distribution function depends only on the opening ratio of the grid electrodes. When the opening ratio of the grid electrodes is fixed, the ion distribution in expanding sheaths can be easily found in various conditions using only a single run of a PIC simulation, and the computation time can be significantly reduced.

  5. Microlens arrays

    NASA Astrophysics Data System (ADS)

    Hutley, Michael C.; Stevens, Richard F.; Daly, Daniel J.

    1992-04-01

    Microlenses have been with us for a long time as indeed the very word lens reminds us. Many early lenses,including those made by Hooke and Leeuwenhoek in the 17th century were small and resembled lentils. Many languages use the same word for both (French tilentillelt and German "Linse") and the connection is only obscure in English because we use the French word for the vegetable and the German for the optic. Many of the applications for arrays of inicrolenses are also well established. Lippmann's work on integral photography at the turn of the century required lens arrays and stimulated an interest that is very much alive today. At one stage, lens arrays played an important part in high speed photography and various schemes have been put forward to take advantage of the compact imaging properties of combinations of lens arrays. The fact that many of these ingenious schemes have not been developed to their full potential has to a large degree been due to the absence of lens arrays of a suitable quality and cost.

  6. Advanced Materials for Neural Surface Electrodes

    PubMed Central

    Schendel, Amelia A.; Eliceiri, Kevin W.; Williams, Justin C.

    2015-01-01

    Designing electrodes for neural interfacing applications requires deep consideration of a multitude of materials factors. These factors include, but are not limited to, the stiffness, biocompatibility, biostability, dielectric, and conductivity properties of the materials involved. The combination of materials properties chosen not only determines the ability of the device to perform its intended function, but also the extent to which the body reacts to the presence of the device after implantation. Advances in the field of materials science continue to yield new and improved materials with properties well-suited for neural applications. Although many of these materials have been well-established for non-biological applications, their use in medical devices is still relatively novel. The intention of this review is to outline new material advances for neural electrode arrays, in particular those that interface with the surface of the nervous tissue, as well as to propose future directions for neural surface electrode development. PMID:26392802

  7. Highly stretchable resistive pressure sensors using a conductive elastomeric composite on a micropyramid array.

    PubMed

    Choong, Chwee-Lin; Shim, Mun-Bo; Lee, Byoung-Sun; Jeon, Sanghun; Ko, Dong-Su; Kang, Tae-Hyung; Bae, Jihyun; Lee, Sung Hoon; Byun, Kyung-Eun; Im, Jungkyun; Jeong, Yong Jin; Park, Chan Eon; Park, Jong-Jin; Chung, U-In

    2014-06-01

    A stretchable resistive pressure sensor is achieved by coating a compressible substrate with a highly stretchable electrode. The substrate contains an array of microscale pyramidal features, and the electrode comprises a polymer composite. When the pressure-induced geometrical change experienced by the electrode is maximized at 40% elongation, a sensitivity of 10.3 kPa(-1) is achieved. PMID:24536023

  8. Electroretinographic wet electrode.

    PubMed

    Carpi, Federico; Benini, Gabriella; Tomei, Franca; Figliuzzi, Rosa Maria; De Napoli, Alberto

    2009-10-01

    This paper presents the first systematic characterisation of a new electroretinographic (ERG) electrode, recently described. The new 'wet' electrode uses a conducting liquid as a distributed electrical interface between the eye and a solid electronic conductor; the latter detects the ERG potential without any direct contact with the ocular surface. This technique avoids the contact-induced discomfort of both corneal and conjunctival standard electrodes. The wet electrode was tested on 10 volunteers, in comparison with a conjunctival electrode (HK loop), as the most comfortable standard. It was also compared with a cutaneous (cup) electrode, which is even more comfortable, although not standard. Results showed the efficacy of the wet electrode for detecting morphologically accurate ERG responses, with amplitudes respectively analogous and higher of those measured by the conjunctival and cutaneous electrodes. Properties of wet electrodes include: no solid interface with the eye, no need for anaesthesia, intrinsic safety, mechanical and electrical stability against ocular movements, tolerance to misplacements and immunity to lacrimation. As a drawback, the liquid can still be a source of discomfort for some patients and it requires care against possible leakage. All these features suggest a possible use of wet electrodes as an additional tool for ERG procedures, although limited to tests of short duration. PMID:19501539

  9. Amplified Thermionic Cooling Using Arrays of Nanowires

    NASA Technical Reports Server (NTRS)

    Yang, Eui-Hyeok; Choi, Daniel; Shcheglov, Kirill; Hishinuma, Yoshikazu

    2007-01-01

    A class of proposed thermionic cooling devices would incorporate precise arrays of metal nanowires as electron emitters. The proposed devices could be highly miniaturized, enabling removal of heat from locations, very close to electronic devices, that have previously been inaccessible for heat-removal purposes. The resulting enhancement of removal of heat would enable operation of the devices at higher power levels and higher clock speeds. Moreover, the mass, complexity, and bulk of electronic circuitry incorporating these highly miniaturized cooling devices could be considerably reduced, relative to otherwise equivalent circuitry cooled by conventional electromechanical, thermoelectric, and fluidic means. In thermionic cooling, one exploits the fact that because only the highest-energy electrons are thermionically emitted, collecting those electrons to prevent their return to the emitting electrode results in the net removal of heat from that electrode. Collection is effected by applying an appropriate positive bias potential to another electrode placed near the emitting electrode. The concept underlying the proposal is that the thermionic-emission current and, hence, the cooling effect attainable by use of an array of nanowires could be significantly greater than that attainable by use of a single emitting electrode or other electron- emitting surface. The wires in an array according to the proposal would protrude perpendicularly from a planar surface and their heights would be made uniform to within a sub-nanometer level of precision

  10. Computation of optimized arrays for 3-D electrical imaging surveys

    NASA Astrophysics Data System (ADS)

    Loke, M. H.; Wilkinson, P. B.; Uhlemann, S. S.; Chambers, J. E.; Oxby, L. S.

    2014-12-01

    3-D electrical resistivity surveys and inversion models are required to accurately resolve structures in areas with very complex geology where 2-D models might suffer from artefacts. Many 3-D surveys use a grid where the number of electrodes along one direction (x) is much greater than in the perpendicular direction (y). Frequently, due to limitations in the number of independent electrodes in the multi-electrode system, the surveys use a roll-along system with a small number of parallel survey lines aligned along the x-direction. The `Compare R' array optimization method previously used for 2-D surveys is adapted for such 3-D surveys. Offset versions of the inline arrays used in 2-D surveys are included in the number of possible arrays (the comprehensive data set) to improve the sensitivity to structures in between the lines. The array geometric factor and its relative error are used to filter out potentially unstable arrays in the construction of the comprehensive data set. Comparisons of the conventional (consisting of dipole-dipole and Wenner-Schlumberger arrays) and optimized arrays are made using a synthetic model and experimental measurements in a tank. The tests show that structures located between the lines are better resolved with the optimized arrays. The optimized arrays also have significantly better depth resolution compared to the conventional arrays.

  11. Photoresponse in arrays of thermoelectric nanowire junctions

    NASA Astrophysics Data System (ADS)

    Huber, T. E.; Scott, R.; Johnson, S.; Brower, T.; Belk, J. H.; Hunt, J. H.

    2013-07-01

    We report the first demonstration of optical detection by thermoelectric nanowire junctions. We employed devices composed of bismuth nanowire arrays which are capped with a transparent indium tin oxide electrode. The incident surface features very low optical reflectivity and enhanced light trapping. The unique attributes of the thermoelectric arrays are the combination of strong temporal and optical wavelength dependences of the photocurrent. Under infrared illumination, the signal can be completely described by thermoelectric effects considering cooling rates given by heat diffusion through the array. In addition, under visible illumination, we observe a photovoltaic response.

  12. Thermoelectric Nanowire Arrays Response to Illumination

    NASA Astrophysics Data System (ADS)

    Huber, Tito; Scott, Reum; Johnson, Scott; Brower, Tina; Nikolaeva, Albina; Konopko, Leonid

    Bismuth nanowire arrays configured on devices where they are capped with a transparent indium tin oxide electrode generate electric power when exposed to light. The arrays feature poor optical reflectivity and, possibly, light trapping. We show experimental results that indicate that the arrays respond to illumination owing to the thermoelectric conversion of heat absorbed at the surface. The unique features of the energy pathway are manifested through a strong temporal and photon wavelength dependence of the photoresponse. Energy conversion in thermoelectrics with light trapping surfaces is a path to fast infrared light detection and across-the-spectrum solar energy harvesting.

  13. Integrated field emission array for ion desorption

    DOEpatents

    Resnick, Paul J; Hertz, Kristin L; Holland, Christopher; Chichester, David; Schwoebel, Paul

    2013-09-17

    An integrated field emission array for ion desorption includes an electrically conductive substrate; a dielectric layer lying over the electrically conductive substrate comprising a plurality of laterally separated cavities extending through the dielectric layer; a like plurality of conically-shaped emitter tips on posts, each emitter tip/post disposed concentrically within a laterally separated cavity and electrically contacting the substrate; and a gate electrode structure lying over the dielectric layer, including a like plurality of circular gate apertures, each gate aperture disposed concentrically above an emitter tip/post to provide a like plurality of annular gate electrodes and wherein the lower edge of each annular gate electrode proximate the like emitter tip/post is rounded. Also disclosed herein are methods for fabricating an integrated field emission array.

  14. Integrated field emission array for ion desorption

    DOEpatents

    Resnick, Paul J; Hertz, Kristin L.; Holland, Christopher; Chichester, David

    2016-08-23

    An integrated field emission array for ion desorption includes an electrically conductive substrate; a dielectric layer lying over the electrically conductive substrate comprising a plurality of laterally separated cavities extending through the dielectric layer; a like plurality of conically-shaped emitter tips on posts, each emitter tip/post disposed concentrically within a laterally separated cavity and electrically contacting the substrate; and a gate electrode structure lying over the dielectric layer, including a like plurality of circular gate apertures, each gate aperture disposed concentrically above an emitter tip/post to provide a like plurality of annular gate electrodes and wherein the lower edge of each annular gate electrode proximate the like emitter tip/post is rounded. Also disclosed herein are methods for fabricating an integrated field emission array.

  15. Global Arrays

    SciTech Connect

    2006-02-23

    The Global Arrays (GA) toolkit provides an efficient and portable “shared-memory” programming interface for distributed-memory computers. Each process in a MIMD parallel program can asynchronously access logical blocks of physically distributed dense multi-dimensional arrays, without need for explicit cooperation by other processes. Unlike other shared-memory environments, the GA model exposes to the programmer the non-uniform memory access (NUMA) characteristics of the high performance computers and acknowledges that access to a remote portion of the shared data is slower than to the local portion. The locality information for the shared data is available, and a direct access to the local portions of shared data is provided. Global Arrays have been designed to complement rather than substitute for the message-passing programming model. The programmer is free to use both the shared-memory and message-passing paradigms in the same program, and to take advantage of existing message-passing software libraries. Global Arrays are compatible with the Message Passing Interface (MPI).

  16. Pacific Array

    NASA Astrophysics Data System (ADS)

    Kawakatsu, H.; Takeo, A.; Isse, T.; Nishida, K.; Shiobara, H.; Suetsugu, D.

    2014-12-01

    Based on our recent results on broadband ocean bottom seismometry, we propose a next generation large-scale array experiment in the ocean. Recent advances in ocean bottom broadband seismometry (e.g., Suetsugu & Shiobara, 2014, Annual Review EPS), together with advances in the seismic analysis methodology, have now enabled us to resolve the regional 1-D structure of the entire lithosphere/asthenosphere system, including seismic anisotropy (both radial and azimuthal), with deployments of ~10-15 broadband ocean bottom seismometers (BBOBSs) (namely "ocean-bottom broadband dispersion survey"; Takeo et al., 2013, JGR; Kawakatsu et al., 2013, AGU; Takeo, 2014, Ph.D. Thesis; Takeo et al., 2014, JpGU). Having ~15 BBOBSs as an array unit for 2-year deployment, and repeating such deployments in a leap-frog way (an array of arrays) for a decade or so would enable us to cover a large portion of the Pacific basin. Such efforts, not only by giving regional constraints on the 1-D structure, but also by sharing waveform data for global scale waveform tomography, would drastically increase our knowledge of how plate tectonics works on this planet, as well as how it worked for the past 150 million years. International collaborations might be sought.

  17. Global Arrays

    Energy Science and Technology Software Center (ESTSC)

    2006-02-23

    The Global Arrays (GA) toolkit provides an efficient and portable “shared-memory” programming interface for distributed-memory computers. Each process in a MIMD parallel program can asynchronously access logical blocks of physically distributed dense multi-dimensional arrays, without need for explicit cooperation by other processes. Unlike other shared-memory environments, the GA model exposes to the programmer the non-uniform memory access (NUMA) characteristics of the high performance computers and acknowledges that access to a remote portion of the sharedmore » data is slower than to the local portion. The locality information for the shared data is available, and a direct access to the local portions of shared data is provided. Global Arrays have been designed to complement rather than substitute for the message-passing programming model. The programmer is free to use both the shared-memory and message-passing paradigms in the same program, and to take advantage of existing message-passing software libraries. Global Arrays are compatible with the Message Passing Interface (MPI).« less

  18. Uncharged positive electrode composition

    DOEpatents

    Kaun, Thomas D.; Vissers, Donald R.; Shimotake, Hiroshi

    1977-03-08

    An uncharged positive-electrode composition contains particulate lithium sulfide, another alkali metal or alkaline earth metal compound other than sulfide, e.g., lithium carbide, and a transition metal powder. The composition along with a binder, such as electrolytic salt or a thermosetting resin is applied onto an electrically conductive substrate to form a plaque. The plaque is assembled as a positive electrode within an electrochemical cell opposite to a negative electrode containing a material such as aluminum or silicon for alloying with lithium. During charging, lithium alloy is formed within the negative electrode and transition metal sulfide such as iron sulfide is produced within the positive electrode. Excess negative electrode capacity over that from the transition metal sulfide is provided due to the electrochemical reaction of the other than sulfide alkali metal or alkaline earth metal compound.

  19. Bifunctional alkaline oxygen electrodes

    NASA Technical Reports Server (NTRS)

    Swette, L.; Kackley, N.; Mccatty, S. A.

    1991-01-01

    The authors describe the identification and testing of electrocatalysts and supports for the positive electrode of moderate-temperature, single-unit, rechargeable alkaline fuel cells. Recent work on Na(x)Pt3O4, a potential bifunctional catalyst, is described, as well as the application of novel approaches to the development of more efficient bifunctional electrode structures. The three dual-character electrodes considered here showed similar superior performance; the Pt/RhO2 and Rh/RhO2 electrodes showed slightly better performance than the Pt/IrO2 electrode. It is concluded that Na(x)Pt3O4 continues to be a promising bifunctional oxygen electrode catalyst but requires further investigation and development.

  20. Bioselective Membrane Electrode Probes

    NASA Astrophysics Data System (ADS)

    Rechnitz, Garry A.

    1981-10-01

    The use of intact bacterial cells or tissue slices of plant and animal origin as immobilized biocatalysts has extended the possible range of potentiometric bioselective membrane electrodes beyond that of conventional enzyme electrodes. The use of such materials as biocatalysts offers advantages in situations where isolated enzymes are not available or where multistep reaction paths are required. The resulting bioselective electrodes also offer exceptional ease of preparation, time stability, and low cost.

  1. Nanoscopic electrode molecular probes

    DOEpatents

    Krstic, Predrag S.; Meunier, Vincent

    2012-05-22

    The present invention relates to a method and apparatus for enhancing the electron transport property measurements of a molecule when the molecule is placed between chemically functionalized carbon-based nanoscopic electrodes to which a suitable voltage bias is applied. The invention includes selecting a dopant atom for the nanoscopic electrodes, the dopant atoms being chemically similar to atoms present in the molecule, and functionalizing the outer surface and terminations of the electrodes with the dopant atoms.

  2. Compound liquid crystal microlens array with convergent and divergent functions.

    PubMed

    Kang, Shengwu; Zhang, Xinyu

    2016-04-20

    Based on the common liquid crystal microlens, a new compound structure for a liquid crystal (LC) microlens array is proposed. The structure consists of two sub LC microlens arrays with properties of light divergence and convergence. The structure has two LC layers: one to form the positive sub lens, one for the negative. The patterned electrode and plane electrode are used in both sub microlens arrays. When two sub microlens arrays are electrically controlled separately, they can diverge or converge the incident light, respectively. As two sub microlens arrays are both applied on the voltage, the focal length of the compound LC microlens becomes larger than that of the LC microlens with a single LC layer. Another feature of a compound LC microlens array is that it can make the target contour become visible under intense light. The mechanisms are described in detail, and the experimental data are given. PMID:27140107

  3. Pocket ECG electrode

    NASA Technical Reports Server (NTRS)

    Lund, Gordon F. (Inventor)

    1982-01-01

    A low-noise electrode suited for sensing electrocardiograms when chronically and subcutaneously implanted in a free-ranging subject. The electrode comprises a pocket-shaped electrically conductive member with a single entrance adapted to receive body fluids. The exterior of the member and the entrance region is coated with electrical insulation so that the only electrolyte/electrode interface is within the member remote from artifact-generating tissue. Cloth straps are bonded to the member to permit the electrode to be sutured to tissue and to provide electrical lead flexure relief.

  4. Pocket ECG electrode

    NASA Technical Reports Server (NTRS)

    Lund, G. F. (Inventor)

    1980-01-01

    A low noise electrode suited for sensing electrocardiograms when chronically and subcutaneously implanted in a free ranging subject is described. The electrode comprises a pocket shaped electrically conductive member with a single entrance adapted to receive body fluids. The exterior of the member and the entrance region is coated with electrical insulation so that the only electrolyte/electrode interface is within the member, remote from artifact-generating tissue. Cloth straps are bonded to the member to permit the electrode to be sutured to tissue and to provide electrical lead flexure relief.

  5. Highly compliant transparent electrodes

    NASA Astrophysics Data System (ADS)

    Shian, Samuel; Diebold, Roger M.; McNamara, Alena; Clarke, David R.

    2012-08-01

    Adaptive optical devices based on electric field induced deformation of dielectric elastomers require transparent and highly compliant electrodes to conform to large shape changes. Electrical, optical, and actuation properties of acrylic elastomer electrodes fabricated with single-walled carbon nanotubes (SWCNTs) and silver nanowires (AgNWs) have been evaluated. Based on these properties, a figure of merit is introduced for evaluating the overall performance of deformable transparent electrodes. This clearly indicates that SWCNTs outperform AgNWs. Under optimal conditions, optical transparency as high as 91% at 190% maximum actuation strain is readily achievable using SWCNT electrodes.

  6. Microelectrode arrays fabricated using a novel hybrid microfabrication method.

    PubMed

    Merlo, Mark W; Snyder, Russell L; Middlebrooks, John C; Bachman, Mark

    2012-02-01

    We present novel hybrid microfabrication methods for microelectrode arrays that combine microwire assembly, microelectromechanical systems (MEMS) manufacturing techniques and precision tool-based micromachining. This combination enables hybrid microfabrication to produce complex geometries and structures, increase material selection, and improve integration. A 32-channel shank microelectrode array was fabricated to highlight the hybrid microfabrication techniques. The electrode shank was 130 μm at its narrowest, had a 127 μm thickness and had iridium oxide electrode sites that were 25 μm in diameter with 150 μm spacing. Techniques used to fabricate this electrode include microassembly of insulated gold wires into a micromold, micromolding the microelectrode shank, post molding machining, sacrificial release of the microelectrode and electrodeposition of iridium oxide onto the microelectrode sites. Electrode site position accuracy was shown to have a standard deviation of less than 4 μm. Acute in vivo recordings with the 32-channel shank microelectrode array demonstrated comparable performance to that obtained with commercial microelectrode arrays. This new approach to microelectrode array fabrication will enable new microelectrodes, such as multi-sided arrays, drug eluding electrodes and biodegradable shanks. PMID:21979567

  7. Microelectrode arrays fabricated using a novel hybrid microfabrication method

    PubMed Central

    Merlo, Mark W.; Snyder, Russell L.; Middlebrooks, John C.; Bachman, Mark

    2011-01-01

    We present novel hybrid microfabrication methods for microelectrode arrays that combine microwire assembly, microelectromechanical systems (MEMS) manufacturing techniques and precision tool-based micromachining. This combination enables hybrid microfabrication to produce complex geometries and structures, increase material selection, and improve integration. A 32-channel shank microelectrode array was fabricated to highlight the hybrid microfabrication techniques. The electrode shank was 130 μm at its narrowest, had a 127 μm thickness and had iridium oxide electrode sites that were 25 μm in diameter with 150 μm spacing. Techniques used to fabricate this electrode include microassembly of insulated gold wires into a micromold, micromolding the microelectrode shank, post molding machining, sacrificial release of the microelectrode and electrodeposition of iridium oxide onto the microelectrode sites. Electrode site position accuracy was shown to have a standard deviation of less than 4 μm. Acute in vivo recordings with the 32-channel shank microelectrode array demonstrated comparable performance to that obtained with commercial microelectrode arrays . This new approach to microelectrode array fabrication will enable new microelectrodes, such as multi-sided arrays, drug eluding electrodes and biodegradable shanks. PMID:21979567

  8. A Multiplexed, Two-Electrode Platform for Biosensing Based on DNA-Mediated Charge Transport.

    PubMed

    Furst, Ariel L; Hill, Michael G; Barton, Jacqueline K

    2015-06-16

    We have developed a thin layer, multiplexed biosensing platform that features two working-electrode arrays for detecting small molecules, nucleic acid sequences, and DNA-binding proteins. DNA duplexes are patterned onto the primary electrode array, while a secondary electrode array is used both to initiate DNA monolayer formation and for electrochemical readout via DNA-mediated charge transport (DNA CT) chemistry. Electrochemical reduction of Cu(phendione)2(2+) (phendione is 1,10-phenanthroline-5,6-dione) at the secondary electrodes induces covalent attachment via click chemistry of ethynyl-labeled DNA probe duplexes onto the primary electrodes that have been treated with azide-terminated alkylthiols. Electrochemical impedance spectroscopy and cyclic voltammetry confirm that catalyst activation at the secondary electrode is essential to maintain the integrity of the DNA monolayer. Electrochemical readout of DNA CT processes that occur at the primary electrode is accomplished also at the secondary electrode. The two-electrode system enables the platform to function as a collector-generator using either ferrocyanide or ferricyanide as mediators with methylene blue and DNA charge transport. Electrochemical measurements at the secondary electrode eliminate the need for large background corrections. The resulting sensitivity of this platform enables the reliable and simultaneous detection of femtomoles of the transcription factors TATA-binding protein and CopG on a single multiplexed device. PMID:26042916

  9. A Multiplexed, Two-Electrode Platform for Biosensing based on DNA-Mediated Charge Transport

    PubMed Central

    Furst, Ariel L.; Hill, Michael G.; Barton, Jacqueline K.

    2015-01-01

    We have developed a thin layer, multiplexed biosensing platform that features two working-electrode arrays for detecting small molecules, nucleic acid sequences, and DNA-binding proteins. DNA duplexes are patterned onto the primary electrode array, while a secondary electrode array is used both to initiate DNA monolayer formation, and for electrochemical readout via DNA-mediated charge transport (DNA CT) chemistry. Electrochemical reduction of Cu(phendione)22+ (phendione is 1,10-phenanthroline-5,6-dione) at the secondary electrodes induces covalent attachment via click chemistry of ethynyl-labeled DNA probe duplexes onto the primary electrodes that have been treated with azide-terminated alkythiols. Electrochemical impedance spectroscopy and cyclic voltammetry confirm that catalyst activation at the secondary electrode is essential to maintain the integrity of the DNA monolayer. Electrochemical readout of DNA CT processes that occur at the primary electrode is accomplished at the secondary electrode. The two-electrode system enables the platform to function as a collector-generator using either ferrocyanide or ferricyanide as mediators with methylene blue and DNA charge transport. Electrochemical measurements at the secondary electrode eliminate the need for large background corrections. The resulting sensitivity of this platform enables the reliable and simultaneous detection of femtomoles of the transcription factors TATA-binding protein and CopG on a single multiplexed device. PMID:26042916

  10. A technique to prevent dural adhesions to chronically implanted microelectrode arrays.

    PubMed

    Maynard, E M; Fernandez, E; Normann, R A

    2000-04-15

    Minimizing relative movements between neural tissues and arrays of microelectrodes chronically implanted into them is expected to greatly enhance the capacity of the microelectrodes to record from single cortical neurons on a long-term basis. We describe a new surgical technique to minimize the formation of adhesions between the dura and an implanted electrode array using a 12 microm (0.5 mil) thick sheet of Teflon film positioned between the array and the dura. A total of 15 cats were implanted using this technique. Gross examination of 12 implant sites at the time of sacrifice failed to find evidence of adhesions between the arrays and the dura when the Teflon(R) film remained in its initial position. In six implants from which recordings were made, an average of nine of the 11 (81%) connected electrodes in each array recorded evoked neural activity after 180 days post implantation. Further, on average, two separable units were identified on each of the implanted electrodes in these arrays. No significant change was found in the density of cell bodies around implanted electrodes of four of the implanted electrode arrays. However, histological evaluation of the implant sites revealed evidence of meningeal proliferation beneath the arrays. The technique described is shown to be effective at preventing adhesions between implanted electrode arrays and improve the characteristics of chronic recordings obtained with these structures. PMID:10788663

  11. Membrane Bioprobe Electrodes

    ERIC Educational Resources Information Center

    Rechnitz, Garry A.

    1975-01-01

    Describes the design of ion selective electrodes coupled with immobilized enzymes which operate either continuously or on drop-sized samples. Cites techniques for urea, L-phenylalanine and amygdalin. Micro size electrodes for use in single cells are discussed. (GH)

  12. Long term flight electrodes

    NASA Technical Reports Server (NTRS)

    Mosier, B.

    1975-01-01

    The reproducibility, stability, and methods of preparation for the various types and forms of biomedical electrodes are discussed. A critical and selective compilation of information on biological and/or physiological electrodes is presented. A discussion of plant hydrocolloids, clays, hydrophyllic colloids, synthetic waxes, and acrylic polymers is included.

  13. Disposable biomedical electrode

    NASA Technical Reports Server (NTRS)

    Frost, J. D., Jr.; Hillman, C. E., Jr.

    1977-01-01

    Reusable recording cap equipped with compressible snap-on bioelectronic electrodes is worn by patient to allow remote monitoring of electroencephalogram and electro-oculogram waveforms. Electrodes can be attached to inside surface of stretch-textile cap at twelve monitoring positions and at one or two ground positions.

  14. Multilayer Ferritin Array for Bionanobattery

    NASA Technical Reports Server (NTRS)

    Chu, Sang-Hyon (Inventor); Choi, Sang H. (Inventor); Kim, Jae-Woo (Inventor); Lillehei, Peter T. (Inventor); Park, Yeonjoon (Inventor); King, Glen C. (Inventor); Elliott, James R., Jr. (Inventor)

    2009-01-01

    A thin-film electrode for a bio-nanobattery is produced by consecutively depositing arrays of a ferritin protein on a substrate, employing a spin self-assembly procedure. By this procedure, a first ferritin layer is first formed on the substrate, followed by building a second, oppositely-charged ferritin layer on the top of the first ferritin layer to form a bilayer structure. Oppositely-charged ferritin layers are subsequently deposited on top of each other until a desired number of bilayer structures is produced. An ordered, uniform, stable and robust, thin-film electrode material of enhanced packing density is presented, which provides optimal charge density for the bio-nanobattery.

  15. Electrodes for microfluidic applications

    DOEpatents

    Crocker, Robert W.; Harnett, Cindy K.; Rognlien, Judith L.

    2006-08-22

    An electrode device for high pressure applications. These electrodes, designed to withstand pressure of greater than 10,000 psi, are adapted for use in microfluidic devices that employ electrokinetic or electrophoretic flow. The electrode is composed, generally, of an outer electrically insulating tubular body having a porous ceramic frit material disposed in one end of the outer body. The pores of the porous ceramic material are filled with an ion conductive polymer resin. A conductive material situated on the upper surface of the porous ceramic frit material and, thus isolated from direct contact with the electrolyte, forms a gas diffusion electrode. A metal current collector, in contact with the gas diffusion electrode, provides connection to a voltage source.

  16. HIGH VOLTAGE ELECTRODES

    DOEpatents

    Murray, J.J.

    1963-04-23

    S>This patent relates to electrode structure for creating an intense direct current electric field which may have a field strength of the order of two to three times that heretofore obtained, with automatic suppression of arcing. The positive electrode is a conventional conductive material such as copper while the negative electrode is made from a special material having a resistivity greater than that of good conductors and less than that of good insulators. When an incipient arc occurs, the moderate resistivity of the negative electrode causes a momentary, localized decrease in the electric field intensity, thus suppressing the flow of electrons and avoiding arcing. Heated glass may be utilized for the negative electrode, since it provides the desired combination of resistivity, capacity, dielectric strength, mechani-cal strength, and thermal stability. (AEC)

  17. Bifunctional catalytic electrode

    NASA Technical Reports Server (NTRS)

    Cisar, Alan (Inventor); Murphy, Oliver J. (Inventor); Clarke, Eric (Inventor)

    2005-01-01

    The present invention relates to an oxygen electrode for a unitized regenerative hydrogen-oxygen fuel cell and the unitized regenerative fuel cell having the oxygen electrode. The oxygen electrode contains components electrocatalytically active for the evolution of oxygen from water and the reduction of oxygen to water, and has a structure that supports the flow of both water and gases between the catalytically active surface and a flow field or electrode chamber for bulk flow of the fluids. The electrode has an electrocatalyst layer and a diffusion backing layer interspersed with hydrophilic and hydrophobic regions. The diffusion backing layer consists of a metal core having gas diffusion structures bonded to the metal core.

  18. A Gold Sensors Array for Imaging The Real Tissue Phantom in Electrical Impedance Tomography

    NASA Astrophysics Data System (ADS)

    Kanti Bera, Tushar; Nagaraju, J.

    2015-02-01

    Surface electrodes in Electrical Impedance Tomography (EIT) phantoms usually reduce the SNR of the boundary potential data due to their design and development errors. A novel gold sensors array with high geometric precision is developed for EIT phantoms to improve the resistivity image quality. Gold thin films are deposited on a flexible FR4 sheet using electro-deposition process to make a sixteen electrode array with electrodes of identical geometry. A real tissue gold electrode phantom is developed with chicken tissue paste and the fat cylinders as the inhomogeneity. Boundary data are collected using a USB based high speed data acquisition system in a LabVIEW platform for different inhomogeneity positions. Resistivity images are reconstructed using EIDORS and compared with identical stainless steel electrode systems. Image contrast parameters are calculated from the resistivity matrix and the reconstructed images are evaluated for both the phantoms. Image contrast and image resolution of resistivity images are improved with gold electrode array.

  19. Bipolar battery with array of sealed cells

    DOEpatents

    Kaun, Thomas D.; Smaga, John A.

    1987-01-01

    A lithium alloy/metal sulfide battery as a dipolar battery is disclosed with an array of stacked cells with the anode and cathode electrode materials in each cell sealed in a confining structure and separated from one another except across separator material interposed therebetween. The separator material is contained in a module having separate perforated metallic sheets that sandwich opposite sides of the separator material for the cell and an annular insulating spacer that surrounds the separator material beyond the perforations and is also sandwiched between and sealed to the sheets. The peripheral edges of the sheets project outwardly beyond the spacer, traverse the side edges of the adjacent electrode material to form cup-like electrode holders, and are fused to the adjacent current collector or end face members of the array. Electrolyte is infused into the electrolyte cavity through the perforations of one of the metallic sheets with the perforations also functioning to allow ionic conductance across the separator material between the adjacent electrodes. A gas-tight housing provides an enclosure of the array.

  20. Nanocrystalline diamond nanoelectrode arrays and ensembles.

    PubMed

    Hees, Jakob; Hoffmann, René; Kriele, Armin; Smirnov, Waldemar; Obloh, Harald; Glorer, Karlheinz; Raynor, Brian; Driad, Rachid; Yang, Nianjun; Williams, Oliver A; Nebel, Christoph E

    2011-04-26

    In this report, the fabrication of all-nanocrystalline diamond (NCD) nanoelectrode arrays (NEAs) by e-beam lithography as well as of all-diamond nanoelectrode ensembles (NEEs) using nanosphere lithography is presented. In this way, nanostructuring techniques are combined with the excellent properties of diamond that are desirable for electrochemical sensor devices. Arrays and ensembles of recessed disk electrodes with radii ranging from 150 to 250 nm and a spacing of 10 μm have been fabricated. Electrochemical impedance spectroscopy as well as cyclic voltammetry was conducted to characterize arrays and ensembles with respect to different diffusion regimes. One outstanding advantage of diamond as an electrode material is the stability of specific surface terminations influencing the electron transfer kinetics. On changing the termination from hydrogen- to oxygen-terminated diamond electrode surface, we observe a dependence of the electron transfer rate constant on the charge of the analyte molecule. Ru(NH(3))(6)(+2/+3) shows faster electron transfer on oxygen than on hydrogen-terminated surfaces, while the anion IrCl(6)(-2/-3) exhibits faster electron transfer on hydrogen-terminated surfaces correlating with the surface dipole layer. This effect cannot be observed on macroscopic planar diamond electrodes and emphasizes the sensitivity of the all-diamond NEAs and NEEs. Thus, the NEAs and NEEs in combination with the efficiency and suitability of the selective electrochemical surface termination offer a new versatile system for electrochemical sensing. PMID:21413786