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1

Geomorphological origin of recession curves  

NASA Astrophysics Data System (ADS)

We identify a previously undetected link between the river network morphology and key recession curves properties through a conceptual-physical model of the drainage process of the riparian unconfined aquifer. We show that the power-law exponent, ?, of -dQ/dt vs. Q curves is related to the power-law exponent of N(l) vs. G(l) curves (which we show to be connected to Hack's law), where l is the downstream distance from the channel heads, N(l) is the number of channel reaches exactly located at a distance l from their channel head, and G(l) is the total length of the network located at a distance greater or equal to l from channel heads. Using Digital Terrain Models and daily discharge observations from 67 US basins we find that geomorphologic ? estimates match well the values obtained from recession curves analyses. Finally, we argue that the link between recession flows and network morphology points to an important role of low-flow discharges in shaping the channel network.

Biswal, Basudev; Marani, Marco

2010-12-01

2

"Universal" Recession Curves and their Geomorphological Roots  

NASA Astrophysics Data System (ADS)

The basic structural organization of channel networks, and of the connected hillslopes, have been shown to be intimately linked to basin responses to rainfall events, leading to geomorphological theories of the hydrologic response. Here, We identify a previously undetected link between the river network morphology and key recession curves properties. We show that the power-law exponent of -dQ/dt vs. Q curves is related to the power-law exponent of N(l) vs. G(l) curves (which we show to be connected to Hack's law), where l is the downstream distance from the channel heads, N(l) is the number of channel reaches exactly located at a distance l from their channel head, and G(l) is the total length of the network located at a distance greater or equal to l from channel heads. We then generalize the power-law expressions of recession curves, to identify "universal" curves, independent of the initial moisture conditions and of basin area, by making the -dQ/dt vs. Q curve non-dimensional using an index discharge representative of initial moisture conditions. We subsequently rescale the geomorphic recession curve, N(l) vs. G(l), producing a collapse of the geomorphic recession curves constructed from the DTM's of 67 US study basins. Finally, by use of the specific discharge u = Q/A, we link the two previous results and define the specific recession curves, whose collapse across basins within homogeneous geographical areas lends further, decisive, support to the notion that the statistical properties of observational recession curves bear the signature of the geomorphological structure of the networks producing them.

Marani, M.; Biswal, B.

2011-12-01

3

The geomorphological origin of recession curves  

NASA Astrophysics Data System (ADS)

We identify a previously undetected link between the river network morphology and key recession curves properties through a conceptual-physical model of the drainage process of the riparian unconfined aquifer. We show that the power-law exponent, ? of -dQ/dt vs Q curves is related to the power-law exponent of N(l) vs G(l) curves (which we show to be connected to Hack's law), where l is the downstream distance from the channel heads, N(l) is the number of channel reaches exactly located at a distance l from their channel head, and G(l) is the total length of the network located at a distance greater or equal to l from channel heads. Using Digital Terrain Models and daily discharge observations from 67 US basins we find that geomorphologic ? estimates match well the values obtained from recession curves analyses. Finally, we argue that the link between recession flows and network morphology points to an important role of low-flow discharges in shaping the channel network.

Biswal, B.; Marani, M.

2010-12-01

4

Baseflow Recession Analysis for Comparison of Drainage Basins and Geology  

Microsoft Academic Search

By means of baseflow recession analysis a method of comparing drainage basins and geologic formations with the aquifers at, maximum performance has been developed. With the technique it is possible to analyze data for perennial and intermittent streams. A minimum of subjective judgments is involved, so that comparable results can be obtained from inde- lendent investigations. The baseflow recession curve

Walter G. Knisel

1963-01-01

5

Interpretation of karst spring recession curves by the series reservoir model  

NASA Astrophysics Data System (ADS)

The analysis of karst spring recession is a commonly used approach for understanding the aquifer structure or acquiring hydrodynamic parameters. An approach frequently applied for recession analysis is based on the several parallel, typically two or three, linear reservoirs each of which represents different part with different hydraulic conductivities, such as the conduit system and the fissure system. However, this parallel reservoir structure cannot accord with the relationship between the conduit system and fissure system, which is actually in series rather than parallel. We, therefore, examine the recession curve of two linear reservoirs in series (the conduit reservoir and fissure reservoir), representing the conduit and fissure system respectively, and make comparisons with two corresponding parallel linear reservoirs. Some interesting results are presented. If the storages of two series systems are close and the recession coefficient of the conduit reservoir is larger than the fissure reservoir, two overlapping exponential recession processes still exist. And yet, the recession coefficient of each exponential process is different from that of each single reservoir. One of recession coefficient is larger than the conduit reservoir owing to extra water participation from the fissure reservoir except the drainage of conduit reservoir, while the other recession coefficient is smaller than the fissure reservoir because the water flowing out from the fissure reservoir is regulated by the conduit reservoir again. When the recession coefficient of conduit reservoir is close or smaller than the fissure system, the recession curve is expressed only by an exponential function and the recession coefficient is between the conduit and fissure system. Commonly, the storage of the conduit system is much smaller than the fissure system and the conduit flow is turbulent. When ignoring the storage of the conduit system, the conduit reservoir can be substituted by a pipe, in which the turbulent pipe flow obeys Darcy-Weisbach formula, in two series reservoir model. In this new conceptual model, the initial recession process deviates from the exponential behavior. This non-exponential recession curve might disappear unless the pipe diameter is large or initial discharge is small. In late recession stage, the recession process is exponential which mainly controlled by the fissure reservoir. Acknowledgments This research was supported by National Natural Science Foundation of China (Grant No. 41030746, 41172207 and 41102147).

chang, Y.; Wu, J.

2013-12-01

6

Geomorphic Signatures on Brutsaert Base Flow Recession Analysis: case study of 27 Swiss Catchments  

NASA Astrophysics Data System (ADS)

Recession flow analysis are crucial in many areas of water resource management and useful to forecast base flow in gauged rivers. Moving from a classical recession curve analysis method, a large set of recession curves has been analyzed from Swiss streamflow data of 27 watersheds. For these catchments, digital elevation models have been precisely analyzed and a method aimed at the geomorphic origins of recession curves has been applied to the Swiss dataset. The method links river network morphology, epitomized by time-varying distribution of contributing channel sites, with the classic parametrization of recession events. This is done by assimilating two scaling exponents, ? and bG, with |dQ/dt|?Q? where Q is at-a-station gauged flow rate and N(l)?G(l)bG where l is the downstream distance from the channel heads receding in time at constant speed c, N(l) is the number of draining channel reaches located at distance l from their heads, and G(l) is the total drainage network length at a distance greater or equal to l. We find that the method provides good results in catchments where drainage density can be regarded as spatially constant. We propose several corrections to the method accounting for arbitrary local drainage densities affecting the local drainage inflow per unit channel length. In particular, we relax the assumption of uniform constant speed c. Such corrections properly vanish when the local drainage density become spatially constant. Overall, definite geomorphic signatures are recognizable for recession curves. In general, we suggest that this conceptual model might be useful to estimate the low flow regime of natural ungauged basins by predicting its features solely from information remotely acquired and objectively manipulated through DEM data.

Mutzner, R.; Bertuzzo, E.; Tarolli, P.; Weijs, S. V.; Nicotina, L.; Ceola, S.; Tomasic, N.; Rodriguez-Iturbe, I.; Parlange, M. B.; Rinaldo, A.

2013-12-01

7

Peak flow rate and recession-curve characteristics of a karst spring in the Inner Bluegrass, central Kentucky  

USGS Publications Warehouse

The flow rate at the terminal spring of a 1929 ha karst ground-water catchment has been continuously monitored for 2 years, and 108 identifiable events were analyzed. The peak flow rates followed a beta frequency distribution with parameters ?? = 0.365 and ?? = 1.135. Events were separated into high-flow and low-flow. High-flow events had characteristics attributable to pipe flow. Correlation and stepwise regression were used to develop peak flow rate prediction equations for the combined 108 events and for the 81 low-flow events. The portion of the recession curve identified as pipe flow was a watershed constant and time invariant. The base flow was seasonal, increasing in the winter to approximately 0.071 m3s-1 and decreasing in the summer to approximately 0.014 m3s-1. ?? 1994.

Felton, G.K.; Currens, J.C.

1994-01-01

8

Hydromorphologic Recession Analysis: Accounting for Human Influences in Watershed Behaviors  

NASA Astrophysics Data System (ADS)

Integrated management of ground and surface waters has generally relied on baseflow characterization to understand the temporal variability in the contribution of watershed storage to streamflow. Recent research, however, indicates that small disturbances attributed to humans can impact our ability to characterize baseflow behaviors. In this study, we present an approach to account for human impacts on the estimation of baseflow recession parameters in California's Central Valley. The framework assesses how baseflow characterization is impacted by the combination of groundwater abstractions and surface water management strategies used to meet both residential and agricultural water demands. The results highlight the importance of accounting for human influences to characterize watershed properties by evaluating traditional (i.e. natural) and human-corrected recession parameters. Such results can influence studies ranging from water resources management to stream restoration projects that rely on accurate accounting of baseflow, especially during low flows.

Thomas, B. F.; Famiglietti, J. S.

2013-12-01

9

Rapid multipoint linkage analysis of recessive traits in nuclear families, including homozygosity mapping  

Microsoft Academic Search

Homozygosity mapping is a powerful strategy for mapping rare recessive traits in children of consanguineous marriages. Practical applications of this strategy are currently limited by the inability of conventional linkage analysis software to compute, in reasonable time, multipoint LOD scores for pedigrees with inbreeding loops. We have developed a new algorithm for rapid multipoint likelihood calculations in small pedigrees, including

Leonid Kruglyak; Mark J. Daly; Eric S. Lander

1995-01-01

10

Sex-linked recessive  

MedlinePLUS

Inheritance - sex-linked recessive; Genetics - sex-linked recessive; X-linked recessive ... X-linked recessive diseases usually occur in males. Males have only one X chromosome. A single recessive ...

11

Numerical Analysis of Galactic Rotation Curves  

E-print Network

In this paper we present the discussion on the salient points of the computational analysis that are at the basis of the paper \\emph{Rotation Curves of Galaxies by Fourth Order Gravity} \\citep{StSc}. In fact in this paper any galactic component (bulge, disk and Dark matter component) required an onerous numerical computation since the Gauss theorem is not applicable in the Fourth Order Gravity. The computational and data analysis have been made with the software Mathematica$^\\circledR$.

Scelza, G

2015-01-01

12

Numerical Analysis of Galactic Rotation Curves  

E-print Network

In this paper we present the discussion on the salient points of the computational analysis that are at the basis of the paper \\emph{Rotation Curves of Galaxies by Fourth Order Gravity} \\citep{StSc}. In fact in this paper any galactic component (bulge, disk and Dark matter component) required an onerous numerical computation since the Gauss theorem is not applicable in the Fourth Order Gravity. The computational and data analysis have been made with the software Mathematica$^\\circledR$.

G. Scelza; A. Stabile

2015-02-01

13

Analysis of geometries with closed timelike curves  

NASA Astrophysics Data System (ADS)

This work deals with the analysis of cylindrically symmetric and stationary space-times mathcal{C}_{t} with closed timelike curves. The equation of motion describing the evolution of a massive scalar field in a mathcal{C}_{t} space-time is obtained. A class of space-times with closed timelike curves describing cosmic strings and cylinders is studied in detail. In such space-times, both massive particles as well as photons can reach the non-causal region. Geodesics and closed timelike curves are calculated and investigated. We have observed that massive particles and photons describe, essentially, two kinds of trajectories: confined orbits and scattering states. The analysis of the light cones show us clearly the intersection between future and past inside the non-causal region. Exact solutions for the equation of motion of massive scalar field propagating in cosmic strings and cylinder space-times are presented. Quasinormal modes for the scalar field have been calculated in static and rotating cosmic cylinders. We found unstable modes in the rotating cases. Rotating as well as static cosmic strings, i.e., without regular interior solutions, do not display quasinormal modes for the scalar field. We conclude presenting a conjecture relating closed timelike curves and space-time instability.

Pavan, A. B.

2010-05-01

14

Incorporating Experience Curves in Appliance Standards Analysis  

SciTech Connect

The technical analyses in support of U.S. energy conservation standards for residential appliances and commercial equipment have typically assumed that manufacturing costs and retail prices remain constant during the projected 30-year analysis period. There is, however, considerable evidence that this assumption does not reflect real market prices. Costs and prices generally fall in relation to cumulative production, a phenomenon known as experience and modeled by a fairly robust empirical experience curve. Using price data from the Bureau of Labor Statistics, and shipment data obtained as part of the standards analysis process, we present U.S. experience curves for room air conditioners, clothes dryers, central air conditioners, furnaces, and refrigerators and freezers. These allow us to develop more representative appliance price projections than the assumption-based approach of constant prices. These experience curves were incorporated into recent energy conservation standards for these products. The impact on the national modeling can be significant, often increasing the net present value of potential standard levels in the analysis. In some cases a previously cost-negative potential standard level demonstrates a benefit when incorporating experience. These results imply that past energy conservation standards analyses may have undervalued the economic benefits of potential standard levels.

Garbesi, Karina; Chan, Peter; Greenblatt, Jeffery; Kantner, Colleen; Lekov, Alex; Meyers, Stephen; Rosenquist, Gregory; Buskirk, Robert Van; Yang, Hung-Chia; Desroches, Louis-Benoit

2011-10-31

15

Whole Exome Analysis Identifies Frequent CNGA1 Mutations in Japanese Population with Autosomal Recessive Retinitis Pigmentosa  

PubMed Central

Objective The purpose of this study was to investigate frequent disease-causing gene mutations in autosomal recessive retinitis pigmentosa (arRP) in the Japanese population. Methods In total, 99 Japanese patients with non-syndromic and unrelated arRP or sporadic RP (spRP) were recruited in this study and ophthalmic examinations were conducted for the diagnosis of RP. Among these patients, whole exome sequencing analysis of 30 RP patients and direct sequencing screening of all CNGA1 exons of the other 69 RP patients were performed. Results Whole exome sequencing of 30 arRP/spRP patients identified disease-causing gene mutations of CNGA1 (four patients), EYS (three patients) and SAG (one patient) in eight patients and potential disease-causing gene variants of USH2A (two patients), EYS (one patient), TULP1 (one patient) and C2orf71 (one patient) in five patients. Screening of an additional 69 arRP/spRP patients for the CNGA1 gene mutation revealed one patient with a homozygous mutation. Conclusions This is the first identification of CNGA1 mutations in arRP Japanese patients. The frequency of CNGA1 gene mutation was 5.1% (5/99 patients). CNGA1 mutations are one of the most frequent arRP-causing mutations in Japanese patients. PMID:25268133

Katagiri, Satoshi; Akahori, Masakazu; Sergeev, Yuri; Yoshitake, Kazutoshi; Ikeo, Kazuho; Furuno, Masaaki; Hayashi, Takaaki; Kondo, Mineo; Ueno, Shinji; Tsunoda, Kazushige; Shinoda, Kei; Kuniyoshi, Kazuki; Tsurusaki, Yohinori; Matsumoto, Naomichi; Tsuneoka, Hiroshi; Iwata, Takeshi

2014-01-01

16

Genetic analysis of loci that contribute to recessive polycystic kidney disease in the mouse  

SciTech Connect

Identification of genes that play a role in the development of autosomal recessive polycystic kidney disease (ARPKD) is a key to the better understanding of this disorder. We have discovered a new mutation in the mouse we call juvenile cystic kidney (jck) which predisposes to the development of ARPKD and is not allelic with any previously described mutations. In an effort to map and positionally clone the jck gene, an intraspecific intercross between B6/DBA jck/+F1 mice was established and over 100 affected progeny were identified. Genotype analysis using microsatellite markers was employed and the jck mutation has been mapped to a 1 cM interval on mouse chromosome 11. Positional cloning of this mutant locus by employing a YAC contig is in progress. Narrowing the region of interest has been facilitated by the utilization of SSCP analysis to develop informative markers from YAC sequence. In addition, it was noted that severity of disease in the intercross progeny (as measured by the degree of kidney enlargement) was more variable than that observed in the parental B6 strain. This suggested that a modifier locus introduced form the DBA background affects the expression of the jck phenotype. We have determined that two additional regions - one from DBA on distal chromosome 10 and a second from B6 on chromosome 1 - are strongly associated with inheritance of a more severe polycystic kidney disease phenotype. The finding of a highly significant association of a B6-related locus with kidney enlargement was completely unexpected, since the PKD phenotype in the original B6 background is not severe. This finding is unambiguous, with a maximal quantitative trait locus (QTL) analysis LOD score of 15 for association with disease severity. We propose that it is the inheritance of both a homozygous B6 locus on chromosome 1 and a DBA gene that results in the severe phenotype, presumably as a consequence of an interaction between their protein products.

Beier, D.R.; Dushkin, H.; Tobin, D. [Harvard Medical School, Boston, MA (United States)] [and others

1994-09-01

17

Recession Rebound  

ERIC Educational Resources Information Center

A return to normal after a crisis is a good thing. Who doesn't want back what once seemed lost? The problem is it usually isn't a simple task figuring out how to patch together a scaled-back training program. When the recession hit in fall 2008, trainers were asked to scale down programming and make do with fewer resources. With a recovery in full…

Weinstein, Margery

2011-01-01

18

Gastrocnemius Recession.  

PubMed

The Grand Rapids Arch Collapse classifications create a novel system for categorizing and correlating numerous common foot and ankle conditions related to a falling arch. The algorithm for treating these conditions is exceptionally replicable and has excellent outcomes. Gastrocnemius equinus diagnosis plays a crucial role in the pathology of arch collapse. A contracture of the gastrocnemius muscle is increasingly recognized as the cause of several foot and ankle conditions. The authors have expanded their indications for gastrocnemius recession to include arch pain without radiographic abnormality, calcaneus apophysitis, plantar fasciitis/fibromas, Achilles tendonosis, early-onset diabetic Charcot arthropathy, and neuropathic forefoot ulcers. PMID:25456721

Anderson, John G; Bohay, Donald R; Eller, Erik B; Witt, Bryan L

2014-12-01

19

Linkage analysis of two families with X-linked recessive congenital motor nystagmus  

Microsoft Academic Search

X-linked recessive congenital motor nystagmus was identified in two Chinese families living in the Guangdong province of China. Nystagmus was noticed in early childhood. Only males in the families were affected and all obligate carriers did not have nystagmus. Linkage study was performed using microsatellite markers at about 10 cM intervals on the X chromosome. The nystagmus in these two families

Xiangming Guo; Shiqiang Li; Xiaoyun Jia; Xueshan Xiao; Panfeng Wang; Qingjiong Zhang

2006-01-01

20

Genetic analysis of autosomal recessive osteopetrosis in Chuvashiya: the unique splice site mutation in TCIRG1 gene spread by the founder effect  

PubMed Central

The rare malignant disorder autosomal recessive osteopetrosis (OPTB) is one of the most prevalent autosomal recessive diseases in the Chuvash Republic of Russia. The purpose of this study was to determine the underlying molecular cause of osteopetrosis in Chuvashiya and to reveal the factors causing the unusual high frequency of the disease in this region. Having assumed a founder effect, we performed linkage disequilibrium (LD) mapping of the OPTB locus at the TCIRG1 region and found a unique splice site mutation c.807+5G>A in all Chuvashian OPTB patients studied. We then analyzed the mutational change in mRNA and detected an intron insertion within the mutant transcript, resulting in a frameshift and premature stop-codon formation (p.Leu271AspfsX231). A decreased expression of the mutant transcript was also detected, which may have been the result of nonsense-mediated decay. Real-time qPCR and MLPA® melting curve analysis-based systems were designed and used for c.807+5G>A mutation screening. In addition to analyzing the gene frequency in Chuvashiya, we also estimated three other populations in the Volga-Ural region (Mari, Udmurt and Bashkir). We found a 1.68% prevalence in Chuvashiya (calculated disease frequency, 1/3500 newborns) and a 0.84% in the Mari population (1/14?000 newborns). The haplotype analysis revealed that all OPTB cases in Chuvashians and Marians originated from a single mutational event and the age of the mutation in Chuvashians was estimated to be approximately 890 years. PMID:19172990

Bliznetz, Elena A; Tverskaya, Svetlana M; Zinchenko, Rena A; Abrukova, Anna V; Savaskina, Ekaterina N; Nikulin, Maxim V; Kirillov, Alexander G; Ginter, Evgeny K; Polyakov, Alexander V

2009-01-01

21

The light curve analysis of MM Herculis  

NASA Astrophysics Data System (ADS)

The photoelectric light curves of MM Her obtained in 1983 and 1984 by Evren (1985, 1987) were analyzed by two different methods. Firstly, the effects of the wave-like distortions on the observations were removed from the observed magnitudes by obtaining its mathematical expression. The remaining light curves were analyzed by using Wood's approach. Later, the light curves of the same years were treated by the method of Wilson-Devinney and distortions seen in the light curves were thought to be explained by locating the spots on the surface of the cooler component. The results obtained by two different approaches are in good agreement.

Evren, S.

1987-10-01

22

Regional estimation of catchment-scale soil properties by means of streamflow recession analysis for use in distributed hydrological models  

NASA Astrophysics Data System (ADS)

The estimation of catchment-scale soil properties, such as water storage capacity and hydraulic conductivity, is of primary interest for the implementation of distributed hydrological models at the regional scale. This estimation is generally done on the basis of information provided by soil databases. However, such databases are often established for agronomic uses and generally do not document deep weathered rock horizons (i.e. pedologic horizons of type C and deeper), which can play a major role in water transfer and storages. Here we define the Drainable Storage Capacity Index (DSCI), an indicator that relies on the comparison of cumulated streamflow and precipitation to assess catchment-scale storage capacities. The DSCI is found to be reliable to detect underestimation of soil storage capacities in soil databases. We also use the streamflow recession analysis methodology defined by Brutsaert and Nieber (Water Resources Research 13(3), 1977) to estimate water storage capacities and lateral saturated hydraulic conductivities of the non-documented deep horizons. The analysis is applied to a sample of twenty-three catchments (0.2 km² - 291 km²) located in the Cévennes-Vivarais region (south of France). In a regionalisation purpose, the obtained results are compared to the dominant catchments geology. This highlights a clear hierarchy between the different geologies present in the area. Hard crystalline rocks are found to be associated to the thickest and less conductive deep soil horizons. Schist rocks present intermediate values of thickness and of saturated hydraulic conductivity, whereas sedimentary rocks and alluvium are found to be the less thick and the most conductive. Consequently, deep soil layers with thicknesses and hydraulic conductivities differing with the geology were added to a distributed hydrological model implemented over the Cévennes-Vivarais region. Preliminary simulations show a major improvement in terms of simulated discharge when compared to simulations done without deep soil layers. KEY WORDS: hydraulic soil properties, streamflow recession, deep soil horizons, soil databases, Boussinesq equation, storage capacity, regionalisation

Vannier, Olivier; Braud, Isabelle; Anquetin, Sandrine

2013-04-01

23

Exclusion of the locus for autosomal recessive pseudohypoaldosteronism type 1 from the mineralocorticoid receptor gene region on human chromosome 4q by linkage analysis  

SciTech Connect

Pseudohypoaldosteronism type 1 (PHA1) is an uncommon inherited disorder characterized by salt-wasting in infancy arising from target organ unresponsiveness to mineralocorticoids. Clinical expression of the disease varies from severely affected infants who may die to apparently asymptomatic individuals. Inheritance is Mendelian and may be either autosomal dominant or autosomal recessive. A defect in the mineralocortiocoid receptor has been implicated as a likely cause of PHA1. The gene for human mineralocorticoid receptor (MLR) has been cloned and physically mapped to human chromosome 4q31.1-31.2. The etiological role of MLR in autosomal recessive PHA1 was investigated by performing linkage analysis between PHA1 and three simple sequence length polymorphisms (D4S192, D4S1548, and D4S413) on chromosome 4q in 10 consanguineous families. Linkage analysis was carried out assuming autosomal recessive inheritance with full penetrance and zero phenocopy rate using the MLINK program for two-point analysis and the HOMOZ program for multipoint analysis. Lod scores of less than -2 were obtained over the whole region from D4S192 to D4S413 encompassing MLR. This provides evidence against MLR as the site of mutations causing PHA1 in the majority of autosomal recessive families. 34 refs., 3 figs., 2 tabs.

Chung, E.; Hanukoglu, A.; Rees, M.; Thompson, R.; Gardiner, R.M. [Univ. College London Medical School, London (United Kingdom)] [and others] [Univ. College London Medical School, London (United Kingdom); and others

1995-10-01

24

Scale Selection for the Analysis of Point-Sampled Curves  

E-print Network

Scale Selection for the Analysis of Point-Sampled Curves: Extended Report Ranjith Unnikrishnan Jean-Franc¸ois Lalonde Nicolas Vandapel Martial Hebert CMU-RI-TR-06-25 June 2006 Robotics Institute Carnegie Mellon

Gupta, Abhinav

25

Theoretical foundations for environmental Kuznets curve analysis  

NASA Astrophysics Data System (ADS)

This thesis provides a dynamic theory for analyzing the paths of aggregate output and pollution in a country over time. An infinite horizon, competitive growth-pollution model is explored in order to determine the role that economic scale, production techniques, and pollution regulations play in explaining the inverted U-shaped relationship between output and some forms of pollution (otherwise known as the Environmental Kuznets Curve, or EKC). Results indicate that the output-pollution relationship may follow a strictly increasing, strictly decreasing (but bounded), inverted U-shaped, or some combination of curves. While the 'scale' effect may cause output and pollution to exhibit a monotonic relationship, 'technique' and 'regulation' effects may ultimately cause a de-linking of these two variables. Pollution-minimizing energy regulation policies are also investigated within this framework. It is found that the EKC may be 'flattened' or even eliminated moving from a poorly-regulated economy to one that minimizes pollution. The model is calibrated to the US economy for output (gross national product, GNP) and two pollutants (sulfur dioxide, SO2, and carbon dioxide, CO2) over the period 1900 to 1990. Results indicate that the model replicates the observations quite well. The predominance of 'scale' effects cause aggregate SO2 and CO2 levels to increase with GNP in the early stages of development. Then, in the case of SO 2, 'technique' and 'regulation' effects may be the cause of falling SO2 levels with continued economic growth (establishing the EKC). CO2 continues to monotonically increase as output levels increase over time. The positive relationship may be due to the lack of regulations on this pollutant. If stricter regulation policies were instituted in the two case studies, an improved allocation of resources may result. While GNP may be 2.596 to 20% lower than what has been realized in the US economy (depending on the pollution variable analyzed), individual welfare may increase from lower pollution levels.

Lantz, Van

26

Straight thinking about groundwater recession  

NASA Astrophysics Data System (ADS)

in catchment and hillslope hydrology a more nuanced approach is now taken to streamflow recession analysis, in the context of major aquifers it is commonly still assumed that the groundwater head recession rate will take exponential form, an idea originally proposed in the 19th Century. However it is shown here that, in early times, the groundwater head recession in a major aquifer should take an almost straight line form with a rate approximately equal to the long-term recharge rate divided by the aquifer storage coefficient. The length of this phase can be estimated from an analytical expression derived in the paper which depends on the aquifer diffusivity, length scale, and the position of the monitoring point. A transitional phase then leads to an exponential phase after some critical time which is independent of the position of the monitoring point. Major aquifers in a state of periodic quasi-steady state are expected to have rates of groundwater flux recession which deviate little from the average rate of groundwater recharge. Where quasi-exponential groundwater declines are observed in nature, their form may be diagnostic of particular types of aquifer properties and/or boundary effects, such as proximity to drainage boundaries, variations in transmissivity with hydraulic head, storage changes due to pumping, nonequilibrium flow at a range of spatial and temporal scales, and variations in specific yield with depth. Recession analysis has applicability to a range of groundwater problems and is powerful way of gaining insight into the hydrologic functioning of an aquifer.

Cuthbert, M. O.

2014-03-01

27

Estimated hydrologic characteristics of shallow aquifer systems in the Valley and Ridge, the Blue Ridge, and the Piedmont physiographic provinces based on analysis of streamflow recession and base flow  

USGS Publications Warehouse

Inferences are drawn about properties of aquifer systems from the interpretation of streamflow records in the Appalachian Valley and Ridge, Piedmont, and Blue Ridge physiographic provinces. The analysis is divided into two parts--analysis of streamflow recession and base-flow analysis. Analysis of recession yields information about aquifer diffusivity and variation in specific yield. Base-flow analysis is used to develop water balances for representative basins in the study area.

Rutledge, A.T.; Mesko, T.O.

1996-01-01

28

Mapping autosomal recessive vitamin D dependency type I to chromosome 12q14 by linkage analysis.  

PubMed Central

Linkage analysis in French-Canadian families with vitamin D dependency type I (VDD1) demonstrated that the gene responsible for the disease is linked to polymorphic RFLP markers in the 12q14 region. We studied 76 subjects in 14 sibships which included 17 affected individuals and 17 obligate heterozygotes. Significant results for linkage were obtained with the D12S17 locus at the male recombination fraction (theta m) .018 (Z[theta m theta f] = 3.20) and with D126 at (theta m = .025 (Z[theta m theta f] = 3.07). Multipoint linkage analysis and studies of haplotypes and recombinants strongly suggest the localization of the VDD1 locus between the collagen type II alpha 1 (COL2A1) locus and clustered loci D12S14, D12S17, and D12S6, which segregate as a three-marker haplotype. Linkage disequilibrium between VDD1 and this three-marker haplotype supports the notion of a founder effect in the studied population. The current status of the localization of the disease allows for carrier detection in the families at risk. PMID:1971995

Labuda, M; Morgan, K; Glorieux, F H

1990-01-01

29

Testing Main Effects and Interactions in Latent Curve Analysis  

ERIC Educational Resources Information Center

A key strength of latent curve analysis (LCA) is the ability to model individual variability in rates of change as a function of 1 or more explanatory variables. The measurement of time plays a critical role because the explanatory variables multiplicatively interact with time in the prediction of the repeated measures. However, this interaction…

Curran, Patrick J.; Bauer, Daniel J.; Willoughby, Michael T.

2004-01-01

30

A regional panel data analysis of the Spanish Beveridge curve  

Microsoft Academic Search

Unemployment is one of the most important problems of the Spanish and European economies. A possible analysis, vastly extended in recent literature, focuses on mismatch problems between labour demand and supply. In this sense, the empirical relationship between the vacancy rate and the unemployment rate, the so-called Beveridge curve, offers a potential instrument to characterise the unemployment of the considered

Jordi Lopez-Tamayo

1998-01-01

31

Recess Makes Kids Smarter  

ERIC Educational Resources Information Center

Recess has been scaled back or cut altogether in a number of schools around the country. The trend can be traced back to the late eighties and was accelerated under No Child Left Behind. Districts under pressure to show academic progress began to squeeze as much instruction into the day as possible. Others eliminated recess because of concerns…

Adams, Caralee

2011-01-01

32

Light Curve and Analysis of the Eclipsing Binary BF Centauri  

NASA Astrophysics Data System (ADS)

The eclipsing binary star BF Centauri was observed photometrically by GWW in the uvby filter system from Mt. John Observatory in New Zealand during 1982, 1989 and 1998. It was also observed spectroscopically at 10 A/mm by W. A. Lawson in 1993 at Mt. Stromlo in Australia to obtain a radial velocity solution. The combined light curves and spectroscopic results have been analyzed using the 1998 version of Robert Wilson's WD light-curve programs. A consistent model for the system will be presented. This analysis was done as a part of a senior research project by MAM, who would like to acknowledge financial support from the Missouri Space Grant Consortium.

Morris, M. A.; Wolf, G. W.

2003-12-01

33

Estimating basin-wide hydraulic parameters of a semi-arid mountainous watershed by recession-flow analysis  

E-print Network

and in watersheds with low population densities because well-drilling to obtain the hydraulic data is expensive;Since well-drilling to estimate hydraulic parameters is often prohibitively expensive in developingEstimating basin-wide hydraulic parameters of a semi-arid mountainous watershed by recession

Walter, M.Todd

34

Bayesian Catch Curve Analysis Institute of Statistics Mimeo Series # 2615  

E-print Network

Catch curves have been used to estimate survival and instantaneous mortality for fish and wildlife populations for many years. In order to better analyze catch curve data from the Apostle Islands population lake trout Salvelinus namaycush in Lake Superior, we develop a Bayesian approach to catch curve analysis. First, the proposed Bayesian approach is illustrated for a single catch curve and then extended to multiple years of data. We also relax the model assumption of a stable age distribution to allow random effects across years. The proposed models are compared with the traditional methods using the focused DIC. There are many potential advantages to the Bayesian approach over the traditional methods such as least squares and maximum likelihood, based on large sample theory. Bayesian estimates are valid for finite samples, and efficient numerical methods can be used to obtain estimates of instantaneous mortality. We conclude that many benefits can be obtained from the Bayesian approach to a single catch curve and to multiple years of data, such as closed-form variance estimates and the ability to both model and estimate the process variation of survival rates.

Emily H. Griffith; Sujit K. Ghosh; Kenneth H. Pollock; Michael J

35

Outcome of ABCA4 disease-associated alleles in autosomal recessive Retinal Dystrophies: Retrospective analysis in 420 Spanish families  

PubMed Central

Objective To provide a comprehensive overview of all detected mutations in the ABCA4 gene in Spanish families with autosomal recessive retinal disorders, including Stargardt disease (arSTGD), cone-rod dystrophy (arCRD), and retinitis pigmentosa (arRP). Also, to assess genotype-phenotype correlation and disease progression in 10 years by considering type of variants and age of onset. Design Case series. Participants A total of 420 unrelated Spanish families: 259 arSTGD, 86 arCRD and 75 arRP. Methods Spanish families were analysed through a combination of ABCR400 genotyping microarray, denaturing High-Performance Liquid Chromatography (dHPLC) and High Resolution Melting (HRM) scanning. Direct sequencing was used as confirmation technique for the identified variants. Screening by Multiple Ligation Probe Analysis (MLPA) was used in order to detect possible large deletions or insertions in the ABCA4 gene. Selected families were further analysed by Next Generation Sequencing (NGS). Main Outcome Measures DNA sequence variants, mutation detection rates, haplotypes, age of onset, central or peripheral vision loss, night blindness. Results Overall, we detected 70.5% and 36.6% of all expected ABCA4 mutations in arSTGD and arCRD patient cohorts, respectively. In the fraction of the cohort where the ABCA4 gene was completely sequenced the detection rates reached 73.6% for STGD and 66.7% for CRD. However, the frequency of possibly pathogenic ABCA4 alleles in arRP families was only slightly higher to that in the general population. Moreover, in some families mutations in other known arRP genes segregated with the disease phenotype. Conclusions An increasing understanding of causal ABCA4 alleles in arSTGD and arCRD facilitates disease diagnosis and prognosis and is also paramount in selecting patients for emerging clinical trials of therapeutic interventions. As ABCA4-associated diseases are evolving retinal dystrophies, assessment of age of onset, accurate clinical diagnosis and genetic testing are crucial. We suggest that ABCA4 mutations may be associated with an RP-like phenotype often as a consequence of severe (null) mutations and/or in cases of long-term, advanced disease. Patients with “classical” arRP phenotypes, especially from the onset of the disease, should be first screened for mutations in known arRP genes and not ABCA4. PMID:23755871

Riveiro-Alvarez, Rosa; Lopez-Martinez, Miguel-Angel; Zernant, Jana; Aguirre-Lamban, Jana; Cantalapiedra, Diego; Avila-Fernandez, Almudena; Gimenez, A.; Lopez-Molina, Maria-Isabel; Garcia-Sandoval, Blanca; Blanco-Kelly, Fiona; Corton, Marta; Tatu, Sorina; Jose, Patricia Fernandez-San; Trujillo-Tiebas, Maria-Jose; Ramos, Carmen; Allikmets, Rando; Ayuso, Carmen

2013-01-01

36

What mainly controls recession flows in river basins?  

NASA Astrophysics Data System (ADS)

The ubiquity of the power law relationship between dQ/dt and Q for recession periods (-dQ/dt=kQ?,Q being discharge at the basin outlet at time t) clearly hints at the existence of a dominant recession flow process that is common to all real basins. It is commonly assumed that a basin, during recession events, functions as a single phreatic aquifer resting on a impermeable horizontal bed or the Dupuit-Boussinesq (DB) aquifer, and with time different aquifer geometric conditions arise that give different values of ? and k. The recently proposed alternative model, geomorphological recession flow model, however, suggests that recession flows are controlled primarily by the dynamics of the active drainage network (ADN). In this study we use data for several basins and compare the above two contrasting recession flow models in order to understand which of the above two factors dominates during recession periods in steep basins. Particularly, we do the comparison by selecting three key recession flow properties: (1) power law exponent ?, (2) dynamic dQ/dt-Q relationship (characterized by k) and (3) recession timescale (time period for which a recession event lasts). Our observations suggest that neither drainage from phreatic aquifers nor evapotranspiration significantly controls recession flows. Results show that the value of ? and recession timescale are not modeled well by DB aquifer model. However, the above mentioned three recession curve properties can be captured satisfactorily by considering the dynamics of the ADN as described by geomorphological recession flow model, possibly indicating that the ADN represents not just phreatic aquifers but the organization of various sub-surface storage systems within the basin.

Biswal, Basudev; Nagesh Kumar, D.

2014-03-01

37

Homozygosity Mapping on Homozygosity Haplotype Analysis to Detect Recessive Disease-Causing Genes from a Small Number of Unrelated, Outbred Patients  

PubMed Central

Genes involved in disease that are not common are often difficult to identify; a method that pinpoints them from a small number of unrelated patients will be of great help. In order to establish such a method that detects recessive genes identical-by-descent, we modified homozygosity mapping (HM) so that it is constructed on the basis of homozygosity haplotype (HM on HH) analysis. An analysis using 6 unrelated patients with Siiyama-type ?1-antitrypsin deficiency, a disease caused by a founder gene, the correct gene locus was pinpointed from data of any 2 patients (length: 1.2–21.8 centimorgans, median: 1.6 centimorgans). For a test population in which these 6 patients and 54 healthy subjects were scrambled, the approach accurately identified these 6 patients and pinpointed the locus to a 1.4-centimorgan fragment. Analyses using synthetic data revealed that the analysis works well for IBD fragment derived from a most recent common ancestor (MRCA) who existed less than 60 generations ago. The analysis is unsuitable for the genes with a frequency in general population more than 0.1. Thus, HM on HH analysis is a powerful technique, applicable to a small number of patients not known to be related, and will accelerate the identification of disease-causing genes for recessive conditions. PMID:21949849

Hagiwara, Koichi; Morino, Hiroyuki; Shiihara, Jun; Tanaka, Tomoaki; Miyazawa, Hitoshi; Suzuki, Tomoko; Kohda, Masakazu; Okazaki, Yasushi; Seyama, Kuniaki; Kawakami, Hideshi

2011-01-01

38

Non-isothermal elastoviscoplastic analysis of planar curved beams  

NASA Technical Reports Server (NTRS)

The development of a general mathematical model and solution methodologies, to examine the behavior of thin structural elements such as beams, rings, and arches, subjected to large nonisothermal elastoviscoplastic deformations is presented. Thus, geometric as well as material type nonlinearities of higher order are present in the analysis. For this purpose a complete true abinito rate theory of kinematics and kinetics for thin bodies, without any restriction on the magnitude of the transformation is presented. A previously formulated elasto-thermo-viscoplastic material constitutive law is employed in the analysis. The methodology is demonstrated through three different straight and curved beams problems.

Simitses, G. J.; Carlson, R. L.; Riff, R.

1988-01-01

39

Production data analysis type curves for the Devonian Shales  

E-print Network

on w: (rp ') A 2 (3) Equation (3) becomes valid in general cases for t & 100m r when 2 eD A?1 2 When (1 -m) 1 and r ?1, Eq. 3 can be approximated as eD Ar log q log ( eD ) ? At 2 (4) Analysis of a large number of Devonian Shale wells indicates... their practical ranges in the Devonian Shales. Varying k, h, 42, (p. -p f), )2, and r for a constant Ar results in a unique curve 2 1 wf e eD over time periods of interest (Figure 4). However, variations of w result in significant changes in curve shape (Figure...

Hazlett, William Gregory

1985-01-01

40

Multi-wavelength analysis of Ellerman Bomb Light Curves  

NASA Astrophysics Data System (ADS)

We present the results of a multi-wavelength photometric analysis of Ellerman Bomb (EB) observations obtained from the Dutch Open Telescope. In our data we have found 6 EBs located in the super-penumbra of the main spot in the active region NOAA 10781. We present light curves of EB observed in the H? line centre and wing +0.7 Å, in the Ca II H line centre and wing~+2.35 Å, in the G-band and in the TRACE 1600 Å filter. We have shown that EBs were visible in the G-band and moreover, there was a good correlation between the light curves in the G-band and in the H? line wings. We also found quasi-periodic oscillations of EBs brightness in the G-band, CaII H line and TRACE 1600 Å filter.

Herlender, M.; Berlicki, A.

41

An analysis of the shapes of ultraviolet extinction curves. III - An atlas of ultraviolet extinction curves  

NASA Technical Reports Server (NTRS)

The basic data needed to produce UV extinction curves for a sample of 78 stars, including spectral types, visual photometry, parameters used to produce fits to the UV extinction curves, distances to the program stars, and line-of-sight H I column densities, are presented. The observational and numerical techniques used to obtain the results are discussed in detail. The UV extinction curves and their analytic fits are shown graphically.

Fitzpatrick, Edward L.; Massa, Derck

1990-01-01

42

New method for calculating a mathematical expression for streamflow recession  

USGS Publications Warehouse

An empirical method has been devised to calculate the master recession curve, which is a mathematical expression for streamflow recession during times of negligible direct runoff. The method is based on the assumption that the storage-delay factor, which is the time per log cycle of streamflow recession, varies linearly with the logarithm of streamflow. The resulting master recession curve can be nonlinear. The method can be executed by a computer program that reads a data file of daily mean streamflow, then allows the user to select several near-linear segments of streamflow recession. The storage-delay factor for each segment is one of the coefficients of the equation that results from linear least-squares regression. Using results for each recession segment, a mathematical expression of the storage-delay factor as a function of the log of streamflow is determined by linear least-squares regression. The master recession curve, which is a second-order polynomial expression for time as a function of log of streamflow, is then derived using the coefficients of this function.

Rutledge, Albert T.

1991-01-01

43

Evaluating the influence of watershed moisture storage on variations in base flow recession rates during prolonged rain-free periods in medium-sized catchments in New York and Illinois, USA  

NASA Astrophysics Data System (ADS)

When dQ/dt-Q plots of stream recession are constructed for individual recession events, the slopes of the dQ/dt-Q curves are near constant in log space, but the intercepts vary seasonally. Because the intercepts increase during the summer (indicating an increase in the recession rate at a given discharge), it has often been assumed that increased evapotranspiration (ET) leads to increased recession rates. To test this assumption, we related the intercepts of dQ/dt-Q curves from 72 recession events to the concurrent ET and watershed moisture storage as determined from the National Center for Environmental Prediction (NCEP) North American Regional Reanalysis (NARR) data set. The analysis suggests that at least for the nine watersheds from Illinois and New York we studied, shifts in recession rate during prolonged rain-free periods had little linkage to concurrent ET. Instead, we observe that the shifting has a moderately strong linkage to watershed moisture storage during the recession event. While this seeming lack of dependence on ET during these prolonged rain-free periods is not necessarily reflective of more normal conditions, we suggest it provides some insight into underlying subsurface controls at the watershed scale. In particular, we hypothesize that the shift in intercept in dQ/dt-Q curves results from spatial heterogeneities in watershed surficial geology; under dryer conditions near-stream subsurface zones with high hydraulic conductivities contribute most streamflow but under wetter conditions subsurface zones in upland areas with lower hydraulic conductivities also contribute.

Shaw, Stephen B.; McHardy, Theodore M.; Riha, Susan J.

2013-09-01

44

Supervision + Recess = Injury Prevention.  

ERIC Educational Resources Information Center

As schools try to do more with less, many PTAs are working with school officials to help improve the school environment. Playground safety is one area where PTAs can make a difference. For example, PTAs can work with schools to schedule volunteers to help with recess supervision. They can also teach children the rules of the playground and how to…

Olsen, Heather M.; Hudson, Susan D.; Thompson, Donna

2002-01-01

45

Analysis of complete fold shape based on quadratic Bézier curves  

NASA Astrophysics Data System (ADS)

Six segments of quadratic Bézier curve are joined together according to some geometrical rules to approximate fold shape. In a classification of folds based on this method, an ideal fold shape is determined by two parameters. The first one, u c, termed the axial lift-up ratio of the central part, generates the folds within a broad spectrum of forms ranging from box folds to chevron folds. The other one, ?, is the interlimb angle. In the quantitative description of complete folds with multiple layers, three new parameters, ?, T and E are used to describe the deflection angle of the axial plane, the thickness increment of hinge zone and the limb elongation, respectively. Based on the modeling method, the program "Bézier Fold Profiler" has been developed, with which most types of folds can be simulated by varying thirteen parameters. Two description methods, complete fold description and individual layer description, can be used for the quantitative analysis of folds. The description methods are carried out by the visual matching of the fold profile displayed on-screen from an imported digital image. The layer curves of the model are displayed on the fold image. This method has the advantage of speed and simplicity.

Liu, Chun; Zhang, Yikun; Wang, Yuan

2009-06-01

46

Concentrated photovoltaics system costs and learning curve analysis  

NASA Astrophysics Data System (ADS)

An extensive set of costs in /W for the installed costs of CPV systems has been amassed from a range of public sources, including both individual company prices and market reports. Cost reductions over time are very evident, with current prices for 2012 in the range of 3.0 ± 0.7 /W and a predicted cost of 1.5 /W for 2020. Cost data is combined with deployment volumes in a learning curve analysis, providing a fitted learning rate of either 18.5% or 22.3% depending on the methodology. This learning rate is compared to that of PV modules and PV installed systems, and the influence of soft costs is discussed. Finally, if an annual growth rate of 39% is assumed for deployed volumes, then, using the learning rate of 20%, this would predict the achievement of a cost point of 1.5 /W by 2016.

Haysom, Joan E.; Jafarieh, Omid; Anis, Hanan; Hinzer, Karin

2013-09-01

47

Geometric nonlinear dynamic analysis of curved beams using curved beam element  

NASA Astrophysics Data System (ADS)

Instead of using the previous straight beam element to approximate the curved beam, in this paper, a curvilinear coordinate is employed to describe the deformations, and a new curved beam element is proposed to model the curved beam. Based on exact nonlinear strain-displacement relation, virtual work principle is used to derive dynamic equations for a rotating curved beam, with the effects of axial extensibility, shear deformation and rotary inertia taken into account. The constant matrices are solved numerically utilizing the Gauss quadrature integration method. Newmark and Newton-Raphson iteration methods are adopted to solve the differential equations of the rigid-flexible coupling system. The present results are compared with those obtained by commercial programs to validate the present finite method. In order to further illustrate the convergence and efficiency characteristics of the present modeling and computation formulation, comparison of the results of the present formulation with those of the ADAMS software are made. Furthermore, the present results obtained from linear formulation are compared with those from nonlinear formulation, and the special dynamic characteristics of the curved beam are concluded by comparison with those of the straight beam.

Pan, Ke-Qi; Liu, Jin-Yang

2011-12-01

48

Are we thinking straight about groundwater recession?  

NASA Astrophysics Data System (ADS)

By exploring what governs the form of groundwater head recession in idealised and real aquifers, it will be shown that the analysis of groundwater recessions is a powerful but underused way of gaining insight into the hydrologic functioning of an aquifer from local to regional scales. It is commonly assumed that groundwater head recession in aquifers will take exponential form. However, here it is demonstrated that ideal regional aquifers should, given enough time between recharge events, actually develop through three distinct phases of recession: (1) in early times the groundwater recession should take an almost straight line form with a rate approximately equal to the long term recharge rate divided by the specific yield. The length of this phase can be estimated from a new analytical expression, which depends on the aquifer diffusivity, length scale and the position of the monitoring point, (2) a transitional phase then leads to, (3) an exponential phase after some critical time which is described by an existing analytical expression which is independent of the position of the monitoring point. Further analysis reveals that major aquifers in a state of periodic quasi-steady state are expected to have rates of net groundwater drainage which deviate little from the average rate of groundwater recharge. To back up these theoretical considerations, a range of real groundwater hydrographs will be presented which demonstrate the characteristic behaviour and interactions of groundwater flow systems interacting at local to regional scales. Where groundwater declines are observed in nature to have a quasi-exponential form, this may be diagnostic of particular types of aquifer properties and/or boundary effects such as: storage changes due to pumping, proximity to drainage boundaries, variations in transmissivity with hydraulic head, and variations in specific yield with depth. Furthermore, 'non-equilibrium' flow at a range of spatial and temporal scales helps explain the recession behaviour of nested flow systems where local scale and regional scale recessions become superposed.

Cuthbert, M. O.

2013-12-01

49

A general geomorphological recession flow model for river basins  

NASA Astrophysics Data System (ADS)

Recession flows in a basin are controlled by the temporal evolution of its active drainage network (ADN). The geomorphological recession flow model (GRFM) assumes that both the rate of flow generation per unit ADN length (q) and the speed at which ADN heads move downstream (c) remain constant during a recession event. Thereby, it connects the power law exponent of -dQ/dt versus Q (discharge at the outlet at time t) curve, ?, with the structure of the drainage network, a fixed entity. In this study, we first reformulate the GRFM for Horton-Strahler networks and show that the geomorphic ? (?g) is equal to D/>(D-1>), where D is the fractal dimension of the drainage network. We then propose a more general recession flow model by expressing both q and c as functions of Horton-Strahler stream order. We show that it is possible to have ? =? g for a recession event even when q and c do not remain constant. The modified GRFM suggests that ? is controlled by the spatial distribution of subsurface storage within the basin. By analyzing streamflow data from 39 U.S. Geological Survey basins, we show that ? is having a power law relationship with recession curve peak, which indicates that the spatial distribution of subsurface storage varies across recession events.

Biswal, Basudev; Nagesh Kumar, D.

2013-08-01

50

Hybrid analytical technique for the nonlinear analysis of curved beams  

NASA Technical Reports Server (NTRS)

The application of a two-step hybrid technique to the geometrically nonlinear analysis of curved beams is used to demonstrate the potential of hybrid analytical techniques in nonlinear structural mechanics. The hybrid technique is based on successive use of the perturbation method and a classical direct variational procedure. The functions associated with the various-order terms in the perturbation expansion of the fundamental unknowns, and their sensitivity derivatives with respect to material and geometric parameters of the beam, are first obtained by using the perturbation method. These functions are selected as coordinate functions (or modes) and the classical direct variational technique is then used to compute their amplitudes. The potential of the proposed hybrid technique for nonlinear analysis of structures is discussed. The effectiveness of the hybrid technique is demonstrated by means of numerical examples. The symbolic computation system Mathematica is used in the present study. The tasks performed on Mathematica include: (1) generation of algebraic expressions for the perturbation functions of the different response quantities and their sensitivity derivatives: and (2) determination of the radius of convergence of the perturbation series.

Noor, A. K.; Andersen, C. M.

1992-01-01

51

Descriptive and Predictive Growth Curves in Energy System Analysis  

Microsoft Academic Search

This study reviews a variety of growth curve models and the theoretical frameworks that lay behind them. In many systems,\\u000a growth patterns are, or must, ultimately be subjected to some form of limitation. A number of curve models have been developed\\u000a to describe and predict such behaviours. Symmetric growth curves have frequently been used for forecasting fossil fuel production,\\u000a but

Mikael Höök; Junchen Li; Noriaki Oba; Simon Snowden

2011-01-01

52

Localized principal component analysis based curve evolution: A divide and conquer approach  

Microsoft Academic Search

We propose a novel localized principal component analysis (PCA) based curve evolution approach which evolves the segmenting curve semi-locally within various target regions (divisions) in an image and then combines these locally accurate segmentation curves to obtain a global segmentation. The training data for our approach consists of training shapes and associated auxiliary (target) masks. The masks indicate the various

Vikram Appia; Balaji Ganapathy; Anthony Yezzi; Tracy Faber

2011-01-01

53

Drainage-system development in consecutive melt seasons at a polythermal, Arctic glacier, evaluated by flow-recession analysis and linear-reservoir simulation  

PubMed Central

[1] The drainage systems of polythermal glaciers play an important role in high-latitude hydrology, and are determinants of ice flow rate. Flow-recession analysis and linear-reservoir simulation of runoff time series are here used to evaluate seasonal and inter-annual variability in the drainage system of the polythermal Finsterwalderbreen, Svalbard, in 1999 and 2000. Linear-flow recessions are pervasive, with mean coefficients of a fast reservoir varying from 16 (1999) to 41 h (2000), and mean coefficients of an intermittent, slow reservoir varying from 54 (1999) to 114 h (2000). Drainage-system efficiency is greater overall in the first of the two seasons, the simplest explanation of which is more rapid depletion of the snow cover. Reservoir coefficients generally decline during each season (at 0.22 h d?1 in 1999 and 0.52 h d?1 in 2000), denoting an increase in drainage efficiency. However, coefficients do not exhibit a consistent relationship with discharge. Finsterwalderbreen therefore appears to behave as an intermediate case between temperate glaciers and other polythermal glaciers with smaller proportions of temperate ice. Linear-reservoir runoff simulations exhibit limited sensitivity to a relatively wide range of reservoir coefficients, although the use of fixed coefficients in a spatially lumped model can generate significant subseasonal error. At Finsterwalderbreen, an ice-marginal channel with the characteristics of a fast reservoir, and a subglacial upwelling with the characteristics of a slow reservoir, both route meltwater to the terminus. This suggests that drainage-system components of significantly contrasting efficiencies can coexist spatially and temporally at polythermal glaciers.

Hodgkins, Richard; Cooper, Richard; Tranter, Martyn; Wadham, Jemma

2013-01-01

54

Growth curve analysis for plasma profiles using smoothing splines  

SciTech Connect

We are developing a profile analysis code for the statistical estimation of the parametric dependencies of the temperature and density profiles in tokamaks. Our code uses advanced statistical techniques to determine the optimal fit, i.e. the fit which minimized the predictive error. For a forty TFTR Ohmic profile dataset, our preliminary results indicate that the profile shape depends almost exclusively on q[sub a][prime] but that the shape dependencies are not Gaussian. We are now comparing various shape models on the TFTR data. In the first six months, we have completed the core modules of the code, including a B-spline package for variable knot locations, a data-based method to determine the optimal smoothing parameters, self-consistent estimation of the bias errors, and adaptive fitting near the plasma edge. Visualization graphics already include three dimensional surface plots, and discharge by discharge plots of the predicted curves with error bars together with the actual measurements values, and plots of the basis functions with errors.

Imre, K.

1993-05-01

55

Iceland Glacier Recession 1997 to 2000  

NSDL National Science Digital Library

This animation is a close up zoom into largest area of glacier recesion at the Breidamerkurjokull glacier in Iceland. The data from 1997 is taken from Landsat 5 and the 2000 data is from Landsat 7. The Breidamerkurjokull glacier in Iceland has been measured by Landsat to be receding since 1973. In 1997, Landsat 5 took several other images of the glacier. It was thought by some glacierologists that this particular glacier was receding quicker in the late 1990s than it did in the late 1980s or 1970s. After careful analysis Goddards Glacierologist, Dorothy Hall, concluded that the recession from 1997 to 2000 occurs at a similar rate to the recession between 1973 and 2000. It is extremely controversial whether or not this recession is caused by global warming.

Perkins, Lori; Hall, Dorothy

2001-04-09

56

Who Suffers during Recessions? NBER Working Paper No. 17951  

ERIC Educational Resources Information Center

In this paper we examine how business cycles affect labor market outcomes in the United States. We conduct a detailed analysis of how cycles affect outcomes differentially across persons of differing age, education, race, and gender, and we compare the cyclical sensitivity during the Great Recession to that in the early 1980s recession. We present…

Hoynes, Hilary W.; Miller, Douglas L.; Schaller, Jessamyn

2012-01-01

57

Automatic generation and analysis of solar cell IV curves  

SciTech Connect

A photovoltaic system includes multiple strings of solar panels and a device presenting a DC load to the strings of solar panels. Output currents of the strings of solar panels may be sensed and provided to a computer that generates current-voltage (IV) curves of the strings of solar panels. Output voltages of the string of solar panels may be sensed at the string or at the device presenting the DC load. The DC load may be varied. Output currents of the strings of solar panels responsive to the variation of the DC load are sensed to generate IV curves of the strings of solar panels. IV curves may be compared and analyzed to evaluate performance of and detect problems with a string of solar panels.

Kraft, Steven M.; Jones, Jason C.

2014-06-03

58

The Study of SLC26A4 Gene Causing Autosomal Recessive Hearing Loss by Linkage Analysis in a Cohort of Iranian Populations  

PubMed Central

Sensorineural non-syndromic hearing loss is the most common disorder which affects 1 in 500 newborns. Hearing loss is an extremely heterogeneous defect with more than 100 loci identified to date. According to the studies, mutations in GJB2 are estimated to be involved in 50- 80% of autosomal recessive non-syndromic hearing loss cases, but contribution of other loci in this disorder is yet ambiguous. With regard to studies, DFNB4 locus (SLC26A4) can be classified as the second cause of hearing loss. So, this study aimed to determine the contribution of this locus in hearing loss as well as the frequency of SLC26A4 gene mutations in a population in the west of Iran. In this descriptive laboratory study, we included 30 families from the west of Iran with no mutation in GJB2 gene. Linkage analysis was performed by DFNB4 (SLC26A4) molecular markers (STR). The families with hearing loss linked to this locus were further analyzed for mutation detection. SLC26A4 gene exons were amplified and analyzed using direct DNA sequencing. In studied families, 2 families displayed linkage to DFNB4 locus. Identified mutations include mutation in exon 5 (c.416 G>T) and in splicing site of exon 7 (IVS-2 A>G or c.919-2 A>G). PMID:25317404

Reiisi, Somayeh; Sanati, Mohammad Hosein; Tabatabaiefar, Mohammad Amin; Ahmadian, Shahla; Reiisi, Salimeh; Parchami, Shahrbanoo; Porjafari, Hamid; Shahi, Heshmat; Shavarzi, Afsaneh; Hashemzade Chaleshtori, Morteza

2014-01-01

59

Fort Play Children Recreate Recess  

ERIC Educational Resources Information Center

Recess beckons well before it actually arrives. Its allure can be heard in children's lunchtime conversations as they discuss imaginary roles, plans, alliances and teams, with an obvious appetite for play and its unbounded possibility. For some children, recess provides the most important reasons to come to school. In team sports, games of chase…

Powell, Mark

2007-01-01

60

Analysis of saturation curves in liquid rare gases [scintillation chambers  

Microsoft Academic Search

A novel method of extrapolation of saturation curves to zero field is proposed. The fraction of electrons escaping from recombination (f o) is determined. On the basis of published experimental data, the fo-value is evaluated for tracks of relativistic electrons in liquid xenon and liquid argon. The fraction of electrons escaping from recombination at zero field is quite considerable. The

K. T. Ospanov; S. G. Pokachalov; I. M. Obodovski

1993-01-01

61

Multiresolution Analysis of UTAT B-spline Curves  

NASA Astrophysics Data System (ADS)

In this paper, we describe a multiresolution curve representation based on periodic uniform tension algebraic trigonometric (UTAT) spline wavelets of class ??? and order four. Then we determine the decomposition and the reconstruction vectors corresponding to UTAT-spline spaces. Finally, we give some applications in order to illustrate the efficiency of the proposed approach.

Lamnii, A.; Mraoui, H.; Sbibih, D.; Zidna, A.

2011-09-01

62

Analysis of Microtubule Dynamics Using Growth Curve Models  

E-print Network

, providing structural support as well as taking part in many of the cellular processes. A large body of data isoforms of a protein tau on micro- tubule dynamics using growth curve models. The results show of 3-repeat tau protein has a similar effect as a 4-repeat tau protein on microtubule dynamics

Jammalamadaka, S. Rao

63

Unsupervised Transient Light Curve Analysis via Hierarchical Bayesian Inference  

NASA Astrophysics Data System (ADS)

Historically, light curve studies of supernovae (SNe) and other transient classes have focused on individual objects with copious and high signal-to-noise observations. In the nascent era of wide field transient searches, objects with detailed observations are decreasing as a fraction of the overall known SN population, and this strategy sacrifices the majority of the information contained in the data about the underlying population of transients. A population level modeling approach, simultaneously fitting all available observations of objects in a transient sub-class of interest, fully mines the data to infer the properties of the population and avoids certain systematic biases. We present a novel hierarchical Bayesian statistical model for population level modeling of transient light curves, and discuss its implementation using an efficient Hamiltonian Monte Carlo technique. As a test case, we apply this model to the Type IIP SN sample from the Pan-STARRS1 Medium Deep Survey, consisting of 18,837 photometric observations of 76 SNe, corresponding to a joint posterior distribution with 9176 parameters under our model. Our hierarchical model fits provide improved constraints on light curve parameters relevant to the physical properties of their progenitor stars relative to modeling individual light curves alone. Moreover, we directly evaluate the probability for occurrence rates of unseen light curve characteristics from the model hyperparameters, addressing observational biases in survey methodology. We view this modeling framework as an unsupervised machine learning technique with the ability to maximize scientific returns from data to be collected by future wide field transient searches like LSST.

Sanders, N. E.; Betancourt, M.; Soderberg, A. M.

2015-02-01

64

Inflation Dynamics and the Great Recession Laurence Ball and Sandeep Mazumder  

E-print Network

Inflation Dynamics and the Great Recession Laurence Ball and Sandeep Mazumder May 2011 Abstract This paper examines inflation dynamics in the Unites States since 1960, with a particular focus on the Great Recession. A puzzle emerges when Phillips curves estimated over 1960- 2007 are used to predict inflation

Niebur, Ernst

65

Fourier techniques for an analysis of eclipsing binary light curves. VIb  

NASA Astrophysics Data System (ADS)

This is a continuation of a previous paper which appeared in this journal (Demircan, 1980b) and aims at ascertaining some other relations between the integral transforms of the light curves of eclipsing binary systems. The appropriate use of these relations should facilitate the numerical computations for an analysis of eclipsing binary light curves by different Fourier techniques

Demircan, O.

1980-10-01

66

Curved Thermopiezoelectric Shell Structures Modeled by Finite Element Analysis  

NASA Technical Reports Server (NTRS)

"Smart" structures composed of piezoelectric materials may significantly improve the performance of aeropropulsion systems through a variety of vibration, noise, and shape-control applications. The development of analytical models for piezoelectric smart structures is an ongoing, in-house activity at the NASA Glenn Research Center at Lewis Field focused toward the experimental characterization of these materials. Research efforts have been directed toward developing analytical models that account for the coupled mechanical, electrical, and thermal response of piezoelectric composite materials. Current work revolves around implementing thermal effects into a curvilinear-shell finite element code. This enhances capabilities to analyze curved structures and to account for coupling effects arising from thermal effects and the curved geometry. The current analytical model implements a unique mixed multi-field laminate theory to improve computational efficiency without sacrificing accuracy. The mechanics can model both the sensory and active behavior of piezoelectric composite shell structures. Finite element equations are being implemented for an eight-node curvilinear shell element, and numerical studies are being conducted to demonstrate capabilities to model the response of curved piezoelectric composite structures (see the figure).

Lee, Ho-Jun

2000-01-01

67

Thermoluminescence glow curve analysis of natural onyx from Turkey.  

PubMed

In this study, the thermoluminesce (TL) properties of natural onyx were determined after ?-irradiation ((9)(0)Sr/(90)Y) at room temperature. The effect of the additive dose and variable heating rate for TL glow peaks of the sample were investigated. Computerized glow curve deconvolution (CGCD) methods were used to determine the number of peaks and kinetic parameters related to the TL glow peaks in natural onyx from Turkey. It was also determined kinetic parameters of onyx by means of the variable heating rate (VHR) method. The sample was exposed to ?-irradiation between 2.4Gy and 2.457kGy. The CGCD methods showed that the glow curve of sample is the superposition of at least six first order components which were ascribed as P1-P6. The dose responses of some peaks have similar patterns and they follow linearity. The effect of heating rates on the response of dosimetric glow peaks of sample was studied. The maximum TL peak intensities of glow curve are decreasing with increasing heating rate and maximum TL peak intensities at 1°C/s drops to 20% of the initial value when the sample is read at 6°C/s. PMID:25474767

Dogan, Tamer; Toktam??, Hüseyin; Yüksel, Mehmet; Topaksu, Mustafa; Necmeddin Yazici, A

2015-02-01

68

Global Analysis of KOI-977: Spectroscopy, Asteroseismology, and Phase-curve Analysis  

NASA Astrophysics Data System (ADS)

We present a global analysis of KOI-977, one of the planet host candidates detected by Kepler. The Kepler Input Catalog (KIC) reports that KOI-977 is a red giant, for which few close-in planets have been discovered. Our global analysis involves spectroscopic and asteroseismic determinations of stellar parameters (e.g., mass and radius) and radial velocity (RV) measurements. Our analyses reveal that KOI-977 is indeed a red giant, possibly in the red clump, but its estimated radius (gsim 20 R ? = 0.093 AU) is much larger than KOI-977.01's orbital distance (~0.027 AU) estimated from its period (P orb ~ 1.35 days) and host star's mass. RV measurements show a small variation, which also contradicts the amplitude of ellipsoidal variations seen in the light curve folded with KOI-977.01's period. Therefore, we conclude that KOI-977.01 is a false positive, meaning that the red giant, for which we measured the radius and RVs, is different from the object that produces the transit-like signal (i.e., an eclipsing binary). On the basis of this assumption, we also perform a light curve analysis including the modeling of transits/eclipses and phase-curve variations, adopting various values for the dilution factor D, which is defined as the flux ratio between the red giant and eclipsing binary. Fitting the whole folded light curve as well as individual transits in the short cadence data simultaneously, we find that the estimated mass and radius ratios of the eclipsing binary are consistent with those of a solar-type star and a late-type star (e.g., an M dwarf) for D >~ 20.

Hirano, Teruyuki; Masuda, Kento; Sato, Bun'ei; Benomar, Othman; Takeda, Yoichi; Omiya, Masashi; Harakawa, Hiroki; Kobayashi, Atsushi

2015-01-01

69

Transit Light Curves with Finite Integration Time: Fisher Information Analysis  

NASA Astrophysics Data System (ADS)

Kepler has revolutionized the study of transiting planets with its unprecedented photometric precision on more than 150,000 target stars. Most of the transiting planet candidates detected by Kepler have been observed as long-cadence targets with 30 minute integration times, and the upcoming Transiting Exoplanet Survey Satellite will record full frame images with a similar integration time. Integrations of 30 minutes affect the transit shape, particularly for small planets and in cases of low signal to noise. Using the Fisher information matrix technique, we derive analytic approximations for the variances and covariances on the transit parameters obtained from fitting light curve photometry collected with a finite integration time. We find that binning the light curve can significantly increase the uncertainties and covariances on the inferred parameters when comparing scenarios with constant total signal to noise (constant total integration time in the absence of read noise). Uncertainties on the transit ingress/egress time increase by a factor of 34 for Earth-size planets and 3.4 for Jupiter-size planets around Sun-like stars for integration times of 30 minutes compared to instantaneously sampled light curves. Similarly, uncertainties on the mid-transit time for Earth and Jupiter-size planets increase by factors of 3.9 and 1.4. Uncertainties on the transit depth are largely unaffected by finite integration times. While correlations among the transit depth, ingress duration, and transit duration all increase in magnitude with longer integration times, the mid-transit time remains uncorrelated with the other parameters. We provide code in Python and Mathematica for predicting the variances and covariances at www.its.caltech.edu/~eprice.

Price, Ellen M.; Rogers, Leslie A.

2014-10-01

70

Determination of the optimum working range from a calibration curve for colorimetric analysis with an "autoanalyzer".  

PubMed

A study has been made of the types and distribution of errors in determining the optimum working range from a calibration curve for automated analysis. Three error equations are derived for the fitting of a linear, quadratic or cubic curve, involving a thorough statistical analysis of the data. The errors from a set of silica and alumina standards, requiring a quadratic and cubic fit respectively, compare favourably with replicate analyses of standard rocks done on a previous occasion. PMID:18961254

Whitehead, D

1973-02-01

71

Characterization of the mutation causative for autosomal recessive hereditary nephropathy in the english cocker spaniel and analysis of gene expression in multiple models of hereditary nephropathy  

E-print Network

syndrome (AS), a group of heterogeneous, hereditary renal diseases, is one example of such a human disease. The disease is transmitted in three fashions: X-linked, autosomal recessive, and autosomal dominant. AS is caused by mutations in COL4?3, COL4?4...

Davidson, Ashley Greene

2009-05-15

72

Spectral Curve Fitting for Automatic Hyperspectral Data Analysis  

E-print Network

Automatic discovery and curve fitting of absorption bands in hyperspectral data can enable the analyst to identify materials present in a scene by comparison with library spectra. This procedure is common in laboratory spectra, but is challenging for sparse hyperspectral data. A procedure for robust discovery of overlapping bands in hyperspectral data is described in this paper. The method is capable of automatically discovering and fitting symmetric absorption bands, can separate overlapping absorption bands in a stable manner, and has relatively low sensitivity to noise. A comparison with techniques already available in the literature is presented using simulated spectra. An application is demonstrated utilizing the shortwave infrared (2.0-2.5 micron or 5000-4000 cm-1) region. A small hyperspectral scene is processed to demonstrate the ability of the method to detect small shifts in absorption wavelength caused by varying white mica chemistry in a natural setting.

Brown, Adrian J

2014-01-01

73

Parent involvement and science achievement: A latent growth curve analysis  

NASA Astrophysics Data System (ADS)

This study examined science achievement growth across elementary and middle school and parent school involvement using the Early Childhood Longitudinal Study - Kindergarten Class of 1998--1999 (ECLS-K). The ECLS-K is a nationally representative kindergarten cohort of students from public and private schools who attended full-day or half-day kindergarten class in 1998--1999. The present study's sample (N = 8,070) was based on students that had a sampling weight available from the public-use data file. Students were assessed in science achievement at third, fifth, and eighth grades and parents of the students were surveyed at the same time points. Analyses using latent growth curve modeling with time invariant and varying covariates in an SEM framework revealed a positive relationship between science achievement and parent involvement at eighth grade. Furthermore, there were gender and racial/ethnic differences in parents' school involvement as a predictor of science achievement. Findings indicated that students with lower initial science achievement scores had a faster rate of growth across time. The achievement gap between low and high achievers in earth, space and life sciences lessened from elementary to middle school. Parents' involvement with school usually tapers off after elementary school, but due to parent school involvement being a significant predictor of eighth grade science achievement, later school involvement may need to be supported and better implemented in secondary schooling.

Johnson, Ursula Yvette

74

A light-curve distortion-wave analysis of eight RS Canum Venaticorum systems  

NASA Astrophysics Data System (ADS)

A program of differential U,B,V photometry of 14 RS CVn systems carried out at Rosemary Hill Observatory in 1978 - 1981 is described, and an analysis of the light curves for the characteristic distortion wave for eight of the systems is presented. The V light curves of the systems are shown. Significant waves were observed in RS CVn, RZ Eri, and RW UMa. No significant waves were found in UX Com, GK Hya, AR Lac, LX Per, or TY Pyx. Unusual light curve distortions were observed in UX Com and AR Lac.

Caton, D. B.

1986-01-01

75

Theoretical analysis of curved Bragg diffraction images from plane wave reference volume holograms.  

PubMed

We analyze the shape of Bragg diffraction images from plane wave reference volume holograms in a 4-f geometry. When the volume hologram is probed by out-of-plane probe beams, the diffraction images become curved lines. Exploiting the k-sphere formulation and Fourier optics analysis, we present both geometrical and analytical solutions of the curved shape, which are distorted ellipses. Parameters and conditions related to the curvature are characterized, and experimental evidence is presented. PMID:19881666

Oh, Se Baek; Watson, Jonathan M; Barbastathis, George

2009-11-01

76

Analysis, design and construction of curved composite girder bridges: State-of-the-art  

Microsoft Academic Search

The horizontally curved composite girder bridges have excellent properties, such as quick construction, good seismic performance,\\u000a saving construction formwork and convenience in spatial arrangement.etc, which have greatly promoted the application of such\\u000a bridges. The objective of this paper is to provide and summarize important references related to the analysis, design and\\u000a construction of curved composite girder bridges. Subjects discussed in

Weiwei Lin; Teruhiko Yoda

2010-01-01

77

Fourier analysis of the light curves of eclipsing variables, XIV  

Microsoft Academic Search

The aim of the present paper will be to utilize the results obtained in the preceding papers of this series for the development of practical procedures for obtaining the elements of any eclipsing system from the observed photometric data by their analysis in the frequency-domain, for any type of eclipses, any proximity of the two components, and any degree of

Zden?k Kopal; Osman Demircan

1978-01-01

78

Rapid genotyping of beak and feather disease virus using high-resolution DNA melt curve analysis.  

PubMed

Beak and feather disease virus (BFDV) is a significant pathogen both for wild and captive psittacine birds globally. Genotypic differentiation of BFDV isolates is crucial to establish effective control strategies for the conservation of endangered species and epidemiological investigations of disease outbreaks. The technique developed in this study is a simple, rapid and inexpensive genotyping method for BFDV using PCR and subsequent high-resolution melt (HRM) curve analysis. This was achieved using PCR amplification of the conserved Rep gene in the presence of a fluorescent DNA intercalating dye (SYTO9). HRM curve analysis of the resultant amplicon could readily differentiate between reference strain (92-SR14) and 18 other BFDV isolates used in this study. Analysis of the nucleotide sequences of the amplicon from each isolate revealed that each melt curve profile was related to a unique DNA sequence. The potential of the PCR-HRM curve analysis to differentiate inter-host genetic variation among critically endangered orange-bellied parrots, lorikeets and cockatoos was also evaluated. Phylogenetic tree topology based on partial Rep gene sequences used in this study showed that BFDV Rep gene sequence patterns were correlated with the results of HRM curve analysis. The results presented in this study indicate that this technique could be used in both clinical research and differentiation of BFDV isolates in a fraction of time without further nucleotide sequencing and provides a novel approach for the genetic screening of BFDV in clinical virology laboratories. PMID:25102431

Sarker, Subir; Ghorashi, Seyed A; Forwood, Jade K; Raidal, Shane R

2014-11-01

79

Horizontally Curved Steel I-Girders State-of-the-Art Analysis Methods  

Microsoft Academic Search

Current AASHTO specifications pertaining to the analysis and design of horizontally curved bridges are based upon research work conducted prior to 1978. Since then a significant amount of work has been conducted to further advance analysis methods and to better understand the behavior of these complex structural systems. Unfortunately, the results of these various research efforts are scattered and, in

A. Zureick; R. Naqib

1999-01-01

80

Gingival recession: prevalence and risk indicators among young greek adults  

PubMed Central

Objectives: The aim of the current research was to assess the prevalence of gingival recession and to investigate possible associations among this condition, periodontal and epidemiological variables in a sample of young Greek adults in a general dental practice. Material and Methods: A total of 1,430 young adults was examined clinically and interviewed regarding several periodontal and epidemiological variables. Collected data included demographic variables, oral hygiene habits and smoking status. Clinical examination included the recording of dental plaque, supragingival calculus presence, gingival status and buccal gingival recession. Multivariate logistic regression analysis model was performed to access the possible association between gingival recession and several periodontal and epidemiological variables as potential risk factors. Results: The overall prevalence of gingival recession was 63.9%. The statistical analysis indicated that higher educational level [OR= 2.12, 95% CI= 0.53-8.51], cigarette smoking [OR= 1.97, 95% CI= 1.48-7.91], frequent tooth brushing [OR= 0.98, 95% CI= 0.56-1.96], presence of oral piercing [OR= 0.92, 95% CI= 0.38-1.58], presence of gingival inflammation [OR= 4.54, 95% CI= 1.68-7.16], presence of dental plaque [OR= 1.67, 95% CI= 0.68-2.83] and presence of supragingival calculus [OR=1.34, 95% CI= 0.59-1.88], were the most important associated factors of gingival recession. Conclusions: The observations of the current research supported the results from previous authors that several periodontal factors, educational level and smoking were significantly associated with the presence of gingival recession, while presence of oral piercing was a new factor that was found to be associated with gingival recession. Key words:Gingival recession, prevalence, risk factors, young adults. PMID:25136424

2014-01-01

81

A new methodology for free wake analysis using curved vortex elements  

NASA Technical Reports Server (NTRS)

A method using curved vortex elements was developed for helicopter rotor free wake calculations. The Basic Curve Vortex Element (BCVE) is derived from the approximate Biot-Savart integration for a parabolic arc filament. When used in conjunction with a scheme to fit the elements along a vortex filament contour, this method has a significant advantage in overall accuracy and efficiency when compared to the traditional straight-line element approach. A theoretical and numerical analysis shows that free wake flows involving close interactions between filaments should utilize curved vortex elements in order to guarantee a consistent level of accuracy. The curved element method was implemented into a forward flight free wake analysis, featuring an adaptive far wake model that utilizes free wake information to extend the vortex filaments beyond the free wake regions. The curved vortex element free wake, coupled with this far wake model, exhibited rapid convergence, even in regions where the free wake and far wake turns are interlaced. Sample calculations are presented for tip vortex motion at various advance ratios for single and multiple blade rotors. Cross-flow plots reveal that the overall downstream wake flow resembles a trailing vortex pair. A preliminary assessment shows that the rotor downwash field is insensitive to element size, even for relatively large curved elements.

Bliss, Donald B.; Teske, Milton E.; Quackenbush, Todd R.

1987-01-01

82

Numerical analysis of curved frequency selective surface by finite-difference time-domain  

NASA Astrophysics Data System (ADS)

Frequency selective surface is a monolayer or multilayer 2D periodic structure which is composed of multiple resonance units scattering by a two-dimensional periodic array on dielectric layer. FSS can't absorb radio frequency energy, but can filter the frequency which is therefore applied in microwave technique or stealth technology. The relative research on curved FSS is relatively scarce since the curved FSS structure can be obtained only when FSS is attached on the materials surfaces of curved structures in engineering application. However, curved FSS is widely applied in practical engineering; therefore, the research on curved FSS structure has important significance. In this paper, a curved FSS structure model of Y-pore unit is established and numerical simulated by means of FDTD. The influence of curvature on FSS transmission characteristics is studied according to the analysis on the changing of radar cross section (RCS). The results show: the center frequency point of the plane band pass FSS structure drifts after the curve surface deformation of the structure; the center frequency point of the curved band pass FSS structure drifts with the changing of the curvature radius, i. e. with the decreasing of curvature radius, the frequency point drifts towards high points and the transmittance decreases. The design of FSS radome demands of accurate and stable center resonance frequency; therefore, the actual situation of curved surface should be considered in practical engineering application when band pass FSS is made into frequency selection filtering radome. The curvature radius should be long enough to avoid center frequency drifting and transmittance deceasing.

Chen, Xin-yi; Wang, Jian-bo; Chen, Gui-bo; Sun, Guan-cheng; Lu, Jun

2011-08-01

83

AtomicJ: an open source software for analysis of force curves.  

PubMed

We present an open source Java application for analysis of force curves and images recorded with the Atomic Force Microscope. AtomicJ supports a wide range of contact mechanics models and implements procedures that reduce the influence of deviations from the contact model. It generates maps of mechanical properties, including maps of Young's modulus, adhesion force, and sample height. It can also calculate stacks, which reveal how sample's response to deformation changes with indentation depth. AtomicJ analyzes force curves concurrently on multiple threads, which allows for high speed of analysis. It runs on all popular operating systems, including Windows, Linux, and Macintosh. PMID:24985823

Hermanowicz, Pawe?; Sarna, Micha?; Burda, Kvetoslava; Gabry?, Halina

2014-06-01

84

AtomicJ: An open source software for analysis of force curves  

NASA Astrophysics Data System (ADS)

We present an open source Java application for analysis of force curves and images recorded with the Atomic Force Microscope. AtomicJ supports a wide range of contact mechanics models and implements procedures that reduce the influence of deviations from the contact model. It generates maps of mechanical properties, including maps of Young's modulus, adhesion force, and sample height. It can also calculate stacks, which reveal how sample's response to deformation changes with indentation depth. AtomicJ analyzes force curves concurrently on multiple threads, which allows for high speed of analysis. It runs on all popular operating systems, including Windows, Linux, and Macintosh.

Hermanowicz, Pawe?; Sarna, Micha?; Burda, Kvetoslava; Gabry?, Halina

2014-06-01

85

Algebra, Home Mortgages, and Recessions  

ERIC Educational Resources Information Center

The current financial crisis and recession in the United States present an opportunity to discuss relevant applications of some topics in typical first-and second-year algebra and precalculus courses. Real-world applications of percent change, exponential functions, and sums of finite geometric sequences can help students understand the problems…

Mariner, Jean A. Miller; Miller, Richard A.

2009-01-01

86

Autosomal Recessive Osteopetrosis in Chuvashiya  

Microsoft Academic Search

A genetic epidemiological study of osteopetrosis was carried out in Chuvashiya. The major signs of this disorder are severe anemia developed in the prenatal or early postnatal life, hepatosplenomegaly, and a progressive loss of sight and hearing. Osteopetrosis showed the autosomal recessive inheritance with a somewhat increased proportion of affected patients in families. The lowest estimate of osteopetrosis frequency in

E. K. Ginter; A. G. Kirillov; E. I. Rogaev

2001-01-01

87

Taxometrics, Polytomous Constructs, and the Comparison Curve Fit Index: A Monte Carlo Analysis  

ERIC Educational Resources Information Center

The taxometric method effectively distinguishes between dimensional (1-class) and taxonic (2-class) latent structure, but there is virtually no information on how it responds to polytomous (3-class) latent structure. A Monte Carlo analysis showed that the mean comparison curve fit index (CCFI; Ruscio, Haslam, & Ruscio, 2006) obtained with 3…

Walters, Glenn D.; McGrath, Robert E.; Knight, Raymond A.

2010-01-01

88

Aptitude-Treatment Interaction Effects on Explicit Rule Learning: A Latent Growth Curve Analysis  

ERIC Educational Resources Information Center

Finding the match between individuals and educational treatments is the aim of both educators and the aptitude-treatment interaction research paradigm. Using the latent growth curve analysis, the present study investigates the interaction between the type of explicit instructional approaches (deductive vs. explicit-inductive) and the level of…

Hwu, Fenfang; Pan, Wei; Sun, Shuyan

2014-01-01

89

Calibration curves of a PGNAA system for cement raw material analysis using the MCNP code  

Microsoft Academic Search

In large samples, the ?-ray count rate of a prompt gamma neutron activation analysis system is a multi-variable function of the elemental dry composition, density, water content and thickness of the material. The experimental calibration curves require tremendous laboratory work, using a great number of standards with well-known compositions. Although a Monte Carlo simulation study does not avoid the experimental

Carlos Oliveira; José Salgado

1998-01-01

90

Computational Tools for Probing Interactions in Multiple Linear Regression, Multilevel Modeling, and Latent Curve Analysis  

ERIC Educational Resources Information Center

Simple slopes, regions of significance, and confidence bands are commonly used to evaluate interactions in multiple linear regression (MLR) models, and the use of these techniques has recently been extended to multilevel or hierarchical linear modeling (HLM) and latent curve analysis (LCA). However, conducting these tests and plotting the…

Preacher, Kristopher J.; Curran, Patrick J.; Bauer, Daniel J.

2006-01-01

91

Linearized limb-darkening coefficients for use in analysis of eclipsing binary light curves  

Microsoft Academic Search

Linear limb-darkening coefficientsu required in the analysis of eclipsing binary curves, are tabulated for a wide range of effective temperature (50 000° to 4000°), wavelength ? (0.2 µ=?=2.2 µ), and gravitiesg (2.0=logg=5.0). The computation is based on the comprehensive range of model atmospheres of Carbon and Gingerich (1969).

Hamid M. Al-Naimiy

1978-01-01

92

Moving Out the Learning Curve: An Analysis of Hard Clam, Mercenaria mercenaria,  

E-print Network

Moving Out the Learning Curve: An Analysis of Hard Clam, Mercenaria mercenaria, Nursery Operations clam mariculture in South Carolina. The cooperative agreement requires Trident Seafanns to provide analyses ofthe nursery phase ofa commercial- scale hard clam farming operation are pre- sented

93

A functional analysis of electrical load curve modelling for some households specific electricity end-uses  

E-print Network

A functional analysis of electrical load curve modelling for some households specific electricity a series of deep technical and behavioural breaks. Among them are : the integration of new electrical domestic end-uses, the development of plug-in hybrid and electric vehicles, the increase of heat pumps

Paris-Sud XI, Université de

94

Beamlet Pyramids: A New Form of Multiresolution Analysis, suited for Extracting Lines, Curves, and Objects  

E-print Network

Beamlet Pyramids: A New Form of Multiresolution Analysis, suited for Extracting Lines, Curves describe a multiscale pyramid of line segments and develop algorithms which exploit that pyramid to recover. The resulting information is stored in an beamlet pyramid. One can use this to rapidly calculate integrals of f

Huo, Xiaoming

95

Inversion Analysis on Surface Wave Dispersion Curves and H\\/V Spectra by Neighbourhood Algorithm  

Microsoft Academic Search

1. Abstract In order to predict strong earthquake ground motion, it is inevitable to construct a relevant subsurface structure model, especially S-wave velocity structure of the site of consideration. Inversion analysis with micro-tremor observation is frequently used to acquire S-wave velocity structure due to its conve- nience and inexpensiveness. Usually inversion analysis is carried out for either dispersion curves or

Eisuke Nagashima; Toshiro Maeda

96

Shape information from glucose curves: Functional data analysis compared with traditional summary measures  

PubMed Central

Background Plasma glucose levels are important measures in medical care and research, and are often obtained from oral glucose tolerance tests (OGTT) with repeated measurements over 2–3?hours. It is common practice to use simple summary measures of OGTT curves. However, different OGTT curves can yield similar summary measures, and information of physiological or clinical interest may be lost. Our mean aim was to extract information inherent in the shape of OGTT glucose curves, compare it with the information from simple summary measures, and explore the clinical usefulness of such information. Methods OGTTs with five glucose measurements over two hours were recorded for 974 healthy pregnant women in their first trimester. For each woman, the five measurements were transformed into smooth OGTT glucose curves by functional data analysis (FDA), a collection of statistical methods developed specifically to analyse curve data. The essential modes of temporal variation between OGTT glucose curves were extracted by functional principal component analysis. The resultant functional principal component (FPC) scores were compared with commonly used simple summary measures: fasting and two-hour (2-h) values, area under the curve (AUC) and simple shape index (2-h minus 90-min values, or 90-min minus 60-min values). Clinical usefulness of FDA was explored by regression analyses of glucose tolerance later in pregnancy. Results Over 99% of the variation between individually fitted curves was expressed in the first three FPCs, interpreted physiologically as “general level” (FPC1), “time to peak” (FPC2) and “oscillations” (FPC3). FPC1 scores correlated strongly with AUC (r=0.999), but less with the other simple summary measures (?0.42?r?0.79). FPC2 scores gave shape information not captured by simple summary measures (?0.12?r?0.40). FPC2 scores, but not FPC1 nor the simple summary measures, discriminated between women who did and did not develop gestational diabetes later in pregnancy. Conclusions FDA of OGTT glucose curves in early pregnancy extracted shape information that was not identified by commonly used simple summary measures. This information discriminated between women with and without gestational diabetes later in pregnancy. PMID:23327294

2013-01-01

97

Induction Motor Fault Diagnosis Using a Hilbert-Park Lissajou's Curve Analysis and Neural Network-Based Decision  

E-print Network

Induction Motor Fault Diagnosis Using a Hilbert-Park Lissajou's Curve Analysis and Neural Network propose an original fault signature based on the Hilbert-Park Lissajou's curve analysis. The performances used. The proposed fault signature does not require a long temporal recording, and their processing

Paris-Sud XI, Université de

98

Management of the Spring Snowmelt Recession in Regulated Systems  

NASA Astrophysics Data System (ADS)

In unregulated rivers in the Sierra Nevada mountains of California, the spring snowmelt recession links high winter flows to low summer baseflow and is a consistent and predictable portion of the annual hydrograph. Consequently, it is an important resource to both riverine ecosystems and California's water supply. In regulated river systems where the spring snowmelt recession is often captured behind dams or diverted for hydropower, restoration of a more natural spring flow regime can provide distinct ecological benefits, such as breeding and migration cues for native species, increased habitat availability, and greater hydraulic habitat diversity. However, knowledge of how to create and manage an ecologically beneficial spring snowmelt recession in a regulated river system has been lacking. This study defined a methodology by which spring flow regimes can be modeled in regulated systems from the quantifiable characteristics of spring snowmelt recessions in unregulated rivers. Using fundamental flow components such as magnitude, timing, and rate of change, the spring snowmelt recession in eight unregulated rivers across the Sierra Nevada range was quantified to gain a better understanding of the predictability and variability across watersheds. The analysis found that unregulated Sierran systems behaved similarly with respect to seasonal patterns and flow recession shape (i.e., recession limb curvature), and thus flows could be modeled in a manner that mimics those predictable characteristics. Using this methodology that quantifies spring recession flows in terms of a daily percent decrease in flow, a series of flow recession scenarios were then created for application on a regulated Sierran river. Four scenarios, ranging from a slow natural recession to a short fast recession typically observed in regulated rivers following cessation of high flow spills, were evaluated within a 2D hydrodynamic model. The effects of the flows on suitable habitat for Foothill yellow-legged frogs, a California species of special concern, were evaluated, and the distribution and diversity of hydraulic habitat through time was assessed. Using a spatial niche approach, the hydraulic habitat conditions were considered with regard to native aquatic species guilds, and the effects of each flow scenario on aquatic biodiversity were determined. The modeling results show that flow recessions with slow ramping rates similar to those observed in unregulated systems (less than 10% per day) were protective of frog egg masses, while flows that receded at rates greater than 10% per day resulted in desiccation of egg masses and potential stranding of newly hatched tadpoles. Furthermore, recession rates of less than 10% per day provided the most diverse hydraulic habitat for an appropriate duration in spring to support all native species guilds and maximize aquatic biodiversity. The predictive flow model described in this study has recently been applied within the Federal Energy Regulatory Commission hydropower relicensing process on the Yuba River to create flow recessions that more naturally transition from high spill flows to minimum instream flows, and is readily adaptable to other snowmelt regions with knowledge of regional unregulated flow characteristics.

Yarnell, S. M.; Lind, A.; Epke, G.; Viers, J. H.

2013-12-01

99

Eprobe Mediated Real-Time PCR Monitoring and Melting Curve Analysis  

PubMed Central

Real-time monitoring of PCR is one of the most important methods for DNA and RNA detection widely used in research and medical diagnostics. Here we describe a new approach for combined real-time PCR monitoring and melting curve analysis using a 3? end-blocked Exciton-Controlled Hybridization-sensitive fluorescent Oligonucleotide (ECHO) called Eprobe. Eprobes contain two dye moieties attached to the same nucleotide and their fluorescent signal is strongly suppressed as single-stranded oligonucleotides by an excitonic interaction between the dyes. Upon hybridization to a complementary DNA strand, the dyes are separated and intercalate into the double-strand leading to strong fluorescence signals. Intercalation of dyes can further stabilize the DNA/DNA hybrid and increase the melting temperature compared to standard DNA oligonucleotides. Eprobes allow for specific real-time monitoring of amplification reactions by hybridizing to the amplicon in a sequence-dependent manner. Similarly, Eprobes allow for analysis of reaction products by melting curve analysis. The function of different Eprobes was studied using the L858R mutation in the human epidermal growth factor receptor (EGFR) gene, and multiplex detection was demonstrated for the human EGFR and KRAS genes using Eprobes with two different dyes. Combining amplification and melting curve analysis in a single-tube reaction provides powerful means for new mutation detection assays. Functioning as “sequence-specific dyes”, Eprobes hold great promises for future applications not only in PCR but also as hybridization probes in other applications. PMID:23951046

Kanamori, Hajime; Tanaka, Yuki; Kimura, Yasumasa; Nakasone, Ayako; Soma, Takahiro; Hayashizaki, Yoshihide; Usui, Kengo; Harbers, Matthias

2013-01-01

100

Using Decline Curve Analysis, Volumetric Analysis, and Bayesian Methodology to Quantify Uncertainty in Shale Gas Reserve Estimates  

E-print Network

on the performance of PDCA methods when the available production data are limited. In addition, PDCA methods have often been coupled with Arp’s equations, which might not be the optimum decline curve analysis model (DCA) to use, as new DCA models for shale reservoirs...

Gonzalez Jimenez, Raul 1988-

2012-11-30

101

On the possibility of using commercial software packages for thermoluminescence glow curve deconvolution analysis.  

PubMed

This paper explores the possibility of using commercial software for thermoluminescence glow curve deconvolution (GCD) analysis. The program PEAKFIT has been used to perform GCD analysis of complex glow curves of quartz and dosimetric materials. First-order TL peaks were represented successfully using the Weibull distribution function. Second-order and general-order TL peaks were represented accurately by using the Logistic asymmetric functions with varying symmetry parameters. Analytical expressions were derived for determining the energy E from the parameters of the Logistic asymmetric functions. The accuracy of these analytical expressions for E was tested for a wide variety of kinetic parameters and was found to be comparable to the commonly used expressions in the TL literature. The effectiveness of fit of the analytical functions used here was tested using the figure of merit (FOM) and was found to be comparable to the accuracy of recently published GCD expressions for first- and general-order kinetics. PMID:12382713

Pagonis, V; Kitis, G

2002-01-01

102

Detection of antigenic variants of the influenza B virus by melting curve analysis with LCGreen  

Microsoft Academic Search

Automated, high-throughput detection methods for single-nucleotide polymorphisms have been applied to the routine genotyping of genetic polymorphisms influencing drug metabolism. Melting curve analysis with LCGreen was introduced recently as one such technique which can be performed rapidly and easily. This technique was used to detect antigenic variants of the influenza B virus. The antigenic variants and vaccine-type strains of the

Toshimasa Nakagawa; Natsumi Higashi; Naoko Nakagawa

2008-01-01

103

Application of progress curve analysis to in situ enzyme kinetics using 1H NMR spectroscopy.  

PubMed

The steady-state kinetics of enzymes in tissues, cells, and concentrated lysates can be characterized using high-resolution nuclear magnetic resonance spectroscopy; this is possible because almost invariably there are differences in the spectra of substrates and products of a reaction and these spectra are obtainable even from optically opaque samples. We used 1H spin-echo NMR spectroscopy to study the hydrolysis of alpha-L-glutamyl-L-alanine by cytosolic peptidases of lysed human erythrocytes. Nonlinear regression of the integrated Michaelis-Menten expression onto the progress-curve data yielded, directly, estimates of Vmax and Km for the hydrolase; a procedure for analyzing progress curves in this manner was adapted and compared with a commonly used procedure which employs the Newton-Raphson algorithm. We also performed a sensitivity analysis of the integrated Michaelis-Menten expression; this yielded equations that indicate under what conditions estimates of Km and Vmax are most sensitive to variations in experimental observables. Specifically, we showed that the most accurate estimates of the steady-state parameters from analysis of progress curves are obtained when the initial substrate concentration is much greater than Km. Furthermore, estimates of these parameters obtained by such an analysis are most sensitive to data obtained when the reaction is 60-80% complete, having started with the highest practicable initial substrate concentration. PMID:3013046

Vandenberg, J I; Kuchel, P W; King, G F

1986-05-15

104

6.RP Games at Recess  

NSDL National Science Digital Library

This is a task from the Illustrative Mathematics website that is one part of a complete illustration of the standard to which it is aligned. Each task has at least one solution and some commentary that addresses important asects of the task and its potential use. Here are the first few lines of the commentary for this task: The students in Mr. Hillâs class played games at recess. $\\hskip30pt$6 boys played soccer $\\hskip30pt$4 girls played soccer $\\hskip30pt$2 boys jumped r...

105

Prediction of Cooling Curves for Squeeze Cast Al/SiCp Composites Using Finite Element Analysis  

NASA Astrophysics Data System (ADS)

This paper reports the experimental and finite element analyses of the solidification behavior of Al/SiCp composites, fabricated by the squeeze casting technique. Experiments were carried out by varying the melt temperatures for cylindrical-shaped composite castings. The composite samples were produced at the following constant temperatures: melt—1023 K, 1073 K, 1123 K, and 1173 K (750 °C, 800 °C, 850 °C, and 900 °C); and die—673 K (400 °C). The pressure applied throughout the experiment is 100 MPa. The melt temperature shows significant influence on the solidification behavior of the metal matrix composite. It was observed that the solidification time was 40 seconds when the melt temperature was 1023 K (750 °C) but it increased to 51 seconds when the melt temperature was at 1173 K (900 °C). The results also showed that the cooling rate decreased on increasing the melt temperature. Cooling curves for our system, squeeze cast composites, were predicted using the finite element software ANSYS. K-type thermocouples were interfaced to the die and the microcomputer from which the experimental cooling curves were constructed. The experimental and predicted cooling curves were then compared. While both show similar trends, the finite element analysis consistently under-predicts the temperature. In addition, finite element stress analysis reveals that both radial and tangential thermal stresses increase with the melt temperature.

Gurusamy, P.; Balasivanandha Prabu, S.; Paskaramoorthy, R.

2015-01-01

106

A computerized glow curve analysis (GCA) method for WinREMS thermoluminescent dosimeter data using MATLAB.  

PubMed

A computerized glow curve analysis (GCA) program for handling of thermoluminescence data originating from WinREMS is presented. The MATLAB program fits the glow peaks using the first-order kinetics model. Tested materials are LiF:Mg,Ti, CaF(2):Dy, CaF(2):Tm, CaF(2):Mn, LiF:Mg,Cu,P, and CaSO(4):Dy, with most having an average figure of merit (FOM) of 1.3% or less, with CaSO(4):Dy 2.2% or less. Output is a list of fit parameters, peak areas, and graphs for each fit, evaluating each glow curve in 1.5 s or less. PMID:21561783

Harvey, John A; Rodrigues, Miesher L; Kearfott, Kimberlee J

2011-09-01

107

The First BVRI Light Curves and Analysis of the Short-period Algol-type Binary DI Hya  

NASA Astrophysics Data System (ADS)

Complete CCD BVRI light curves of the eclipsing binary DI Hya are symmetric, with the secondary minimum markedly deeper at longer wavelengths, indicating a large temperature difference between the components. Analysis of the light curves indicates a detached near-contact system with relatively unevolved members.

Manimanis, V. N.; Niarchos, P. G.

2007-12-01

108

Kinematic analysis of the technique for elite male long-distance speed skaters in curving.  

PubMed

The purpose of this study was to investigate technical factors for maintaining skating velocity by kinematic analysis of the skating motion for elite long-distance skaters during the curve phase in official championship races. Sixteen world-class elite male skaters who participated in the 5,000-m race were videotaped with two synchronized high-speed video cameras (250 Hz) in a curve lane by using a panning DLT technique. Three-dimensional coordinates of the body and blades during the first and second halves of the races were collected to calculate kinematic parameters. In the group that maintained greater skating velocity, the thigh angle during the gliding phase of the left stroke during the second half was greater than that during the first half, and the center of mass was located more forward during the second half. Thus, it was suggested that long-distance speed skaters should change the support leg position during the gliding phase in the left stroke of the curve phase under fatigued conditions so that they could extend the support leg with a forward rotation of the thigh and less shank backward rotation. PMID:17603132

Juda, Jun; Yuki, Masahiro; Aoyanagi, Toru; Fujii, Norihisa; Ae, Michiyoshi

2007-05-01

109

Image-plane Analysis of n-point-mass Lens Critical Curves and Caustics  

E-print Network

The interpretation of gravitational microlensing events caused by planetary systems or multiple stars is based on the n-point mass lens model. The first planets detected by microlensing were well described by the two-point-mass model of a star with one planet. By the end of 2014, four events involving three-point-mass lenses had been announced. Two of the lenses were stars with two planetary companions each; two were binary stars with a planet orbiting one component. While the two-point-mass model is well understood, the same cannot be said for lenses with three or more components. Even the range of possible critical-curve topologies and caustic geometries of the three-point-mass lens remains unknown. In this paper we provide new tools for mapping the critical-curve topology and caustic cusp number in the parameter space of n-point-mass lenses. We perform our analysis in the image plane of the lens. We show that all contours of the Jacobian are critical curves of re-scaled versions of the lens configuration. ...

Danek, Kamil

2015-01-01

110

STR melting curve analysis as a genetic screening tool for crime scene samples.  

PubMed

In this proof-of-concept study, high-resolution melt curve (HRMC) analysis was investigated as a postquantification screening tool to discriminate human CSF1PO and THO1 genotypes amplified with mini-STR primers in the presence of SYBR Green or LCGreen Plus dyes. A total of 12 CSF1PO and 11 HUMTHO1 genotypes were analyzed on the LightScanner HR96 and LS-32 systems and were correctly differentiated based upon their respective melt profiles. Short STR amplicon melt curves were affected by repeat number, and single-source and mixed DNA samples were additionally differentiated by the formation of heteroduplexes. Melting curves were shown to be unique and reproducible from DNA quantities ranging from 20 to 0.4 ng and distinguished identical from nonidentical genotypes from DNA derived from different biological fluids and compromised samples. Thus, a method is described which can assess both the quantity and the possible probative value of samples without full genotyping. PMID:22486563

Nguyen, Quang; McKinney, Jason; Johnson, Donald J; Roberts, Katherine A; Hardy, Winters R

2012-07-01

111

A rapid detection for ?-thalassemia by PCR combined with dissociation curve analysis.  

PubMed

Deletion mutations of 3.7 kb and 4.2 kb of ?-globin gene are the most common causes of ?-thalassemia (-?(3.7)/, -?(4.2)/). A simple, rapid assay by using a single-tube PCR to detect the two deletions has been needed. In this study, a pair of shared primers was designed for ?2 and ?1 gene but with length-different amplicons (159 bp and 409 bp). On the dissociation curve analysis profile after PCR, there shows two obvious peaks which represent the two different amplicons. Relative copy number of ?2 and ?1 gene can be deduced from the ratio of the two peaks. A comprehensive diagnosis for ?-thalassemia 10 genotypes of deletions can be achieved when combined with a single-tube duplex PCR for detecting --SEA and non-deletional alleles of ?? or ?(T)?. Besides, a single-tube multiplex PCR, which is a cost-effective version of dual-priming-oligonucleotide based system, was designed for two common mutations of ?-thalassemia in China (Hb Constant Spring and Hb Quong Sze), and these two mutations can be identified in samples by use of dissociation curve analysis. In all, using above three PCRs followed by dissociation curve analysis, three deletions and two mutations of ?-thalassemia in the populations of southern China and Southeast Asia can be detected for molecular diagnosis or prenatal diagnosis. A blinded study of 163 samples was performed using this new assay and it was concordant with the original methods. This comprehensive molecular assay is simple, rapid, automatic and cost-effective, and can be used to diagnose ?-thalassemia in this geographical area. PMID:21806986

Jia, Xingyuan; Liu, Jingzhong; Wang, Lirong; Yao, Limei; Tang, Ning; Cai, Ren; Xiao, Bai

2011-10-01

112

The Crucial Role of Recess in Schools  

ERIC Educational Resources Information Center

Background: Recess is at the heart of a vigorous debate over the role of schools in promoting optimal child development and well-being. Reallocating time to accentuate academic concerns is a growing trend and has put recess at risk. Conversely, pressure to increase activity in school has come from efforts to combat childhood obesity. The purpose…

Ramstetter, Catherine L.; Murray, Robert; Garner, Andrew S.

2010-01-01

113

On the Analysis and Construction of the Butterfly Curve Using "Mathematica"[R  

ERIC Educational Resources Information Center

The butterfly curve was introduced by Temple H. Fay in 1989 and defined by the polar curve r = e[superscript cos theta] minus 2 cos 4 theta plus sin[superscript 5] (theta divided by 12). In this article, we develop the mathematical model of the butterfly curve and analyse its geometric properties. In addition, we draw the butterfly curve and…

Geum, Y. H.; Kim, Y. I.

2008-01-01

114

Antigen-antibody biorecognition events as discriminated by noise analysis of force spectroscopy curves  

NASA Astrophysics Data System (ADS)

Atomic force spectroscopy is able to extract kinetic and thermodynamic parameters of biomolecular complexes provided that the registered unbinding force curves could be reliably attributed to the rupture of the specific complex interactions. To this aim, a commonly used strategy is based on the analysis of the stretching features of polymeric linkers which are suitably introduced in the biomolecule-substrate immobilization procedure. Alternatively, we present a method to select force curves corresponding to specific biorecognition events, which relies on a careful analysis of the force fluctuations of the biomolecule-functionalized cantilever tip during its approach to the partner molecules immobilized on a substrate. In the low frequency region, a characteristic 1/f ? noise with ? equal to one (flickering noise) is found to replace white noise in the cantilever fluctuation power spectrum when, and only when, a specific biorecognition process between the partners occurs. The method, which has been validated on a well-characterized antigen-antibody complex, represents a fast, yet reliable alternative to the use of linkers which may involve additional surface chemistry and reproducibility concerns.

Bizzarri, Anna Rita; Cannistraro, Salvatore

2014-08-01

115

Nonlinear Analysis and Post-Test Correlation for a Curved PRSEUS Panel  

NASA Technical Reports Server (NTRS)

The Pultruded Rod Stitched Efficient Unitized Structure (PRSEUS) concept, developed by The Boeing Company, has been extensively studied as part of the National Aeronautics and Space Administration's (NASA s) Environmentally Responsible Aviation (ERA) Program. The PRSEUS concept provides a light-weight alternative to aluminum or traditional composite design concepts and is applicable to traditional-shaped fuselage barrels and wings, as well as advanced configurations such as a hybrid wing body or truss braced wings. Therefore, NASA, the Federal Aviation Administration (FAA) and The Boeing Company partnered in an effort to assess the performance and damage arrestments capabilities of a PRSEUS concept panel using a full-scale curved panel in the FAA Full-Scale Aircraft Structural Test Evaluation and Research (FASTER) facility. Testing was conducted in the FASTER facility by subjecting the panel to axial tension loads applied to the ends of the panel, internal pressure, and combined axial tension and internal pressure loadings. Additionally, reactive hoop loads were applied to the skin and frames of the panel along its edges. The panel successfully supported the required design loads in the pristine condition and with a severed stiffener. The panel also demonstrated that the PRSEUS concept could arrest the progression of damage including crack arrestment and crack turning. This paper presents the nonlinear post-test analysis and correlation with test results for the curved PRSEUS panel. It is shown that nonlinear analysis can accurately calculate the behavior of a PRSEUS panel under tension, pressure and combined loading conditions.

Gould, Kevin; Lovejoy, Andrew E.; Jegley, Dawn; Neal, Albert L.; Linton, Kim, A.; Bergan, Andrew C.; Bakuckas, John G., Jr.

2013-01-01

116

Adhesive elements for stress analysis of bonded patch to curved thin-walled structures  

NASA Astrophysics Data System (ADS)

Bonded composite patching has been recognized as an efficient and economical method to extend the service life of cracked aluminum components. However, current analysis methods and empirical databases for designing composite bonded joint and patch repair are limited to flat plate and/or flat laminate geometries, and the effect of curvature on the performance and durability of composite bonded joints and repairs is not known. This paper presents a novel finite element formulation for developing adhesive elements for conducting quick stress analysis of bonded repairs to curved structures. Illustrative examples are presented to demonstrate the effect of curvature and the effect of patch location, i.e., internal and external patches, patch size and patch thickness on stresses in adhesive layer.

Tong, L.; Sun, X.

117

Cooling Curve Analysis as an Alternative to Dilatometry in Continuous Cooling Transformations  

NASA Astrophysics Data System (ADS)

Dilatometry and cooling curve analysis (CCA) are two methods of determining the evolution of a phase transformation with temperature. The two methods are similar conceptual in that they take an indirect measure of the transformation and extract phase fraction information from it; however, the differences between the two methods typically makes one method better suited to analyzing a given transformation. However, without a quantitative comparison between the two methods, it is difficult to use them interchangeably. We address this by presenting a quantitative comparison of CCA and dilatometry for a martensitic transformation in a 9Cr3W3CoVNb steel. The resulting phase fraction data matches very well, within 5 K (5 °C) for any given phase fraction. This paper also extends to the quantitative methodology of calorimetry to the analysis of dilatometric data, with results comparable to ASTM A1033-10, but with expected higher accuracy by accounting by variable thermal expansion coefficients.

Gibbs, John W.; Schlacher, Christian; Kamyabi-Gol, Ata; Mayr, Peter; Mendez, Patricio F.

2015-01-01

118

The composition-explicit distillation curve technique: Relating chemical analysis and physical properties of complex fluids.  

PubMed

The analysis of complex fluids such as crude oils, fuels, vegetable oils and mixed waste streams poses significant challenges arising primarily from the multiplicity of components, the different properties of the components (polarity, polarizability, etc.) and matrix properties. We have recently introduced an analytical strategy that simplifies many of these analyses, and provides the added potential of linking compositional information with physical property information. This aspect can be used to facilitate equation of state development for the complex fluids. In addition to chemical characterization, the approach provides the ability to calculate thermodynamic properties for such complex heterogeneous streams. The technique is based on the advanced distillation curve (ADC) metrology, which separates a complex fluid by distillation into fractions that are sampled, and for which thermodynamically consistent temperatures are measured at atmospheric pressure. The collected sample fractions can be analyzed by any method that is appropriate. The analytical methods we have applied include gas chromatography (with flame ionization, mass spectrometric and sulfur chemiluminescence detection), thin layer chromatography, FTIR, corrosivity analysis, neutron activation analysis and cold neutron prompt gamma activation analysis. By far, the most widely used analytical technique we have used with the ADC is gas chromatography. This has enabled us to study finished fuels (gasoline, diesel fuels, aviation fuels, rocket propellants), crude oils (including a crude oil made from swine manure) and waste oils streams (used automotive and transformer oils). In this special issue of the Journal of Chromatography, specifically dedicated to extraction technologies, we describe the essential features of the advanced distillation curve metrology as an analytical strategy for complex fluids. PMID:20004402

Bruno, Thomas J; Ott, Lisa S; Lovestead, Tara M; Huber, Marcia L

2010-04-16

119

Association of gingival recession and other factors with the presence of dentin hypersensitivity.  

PubMed

Dentin hypersensitivity (DH) may be present in association with gingival recession. The aim of this study was to determine quantitatively the association of gingival recession and other factors with the presence of DH. One hundred and four Japanese subjects with or without gingival recession were randomly selected. Intact canines and/or first premolars in both maxillary and mandibular quadrants were analyzed. Gingival recession was measured as a vertical length at the buccal site of the teeth. DH was recorded as an ordered categorical variable registering four increasing levels of pain after cold stimulation; from no discomfort to severe pain during and after stimulation (DH1, 2, 3, and 4). Association of DH with periodontal parameters and daily lifestyle was also investigated. Tooth-based analysis of 446 teeth from 104 subjects revealed that DH level was significantly higher in recessive teeth (1, 2, 3, and 4-8 mm) than in non-recessive teeth (0 mm). DH-positive rate in non-recessive teeth was only 18 % (DH1; 14 %, DH2; 3 %, and DH3; 1 %). Highest DH level was observed in teeth with severe recession (4-8 mm), showing DH0; 21 %, DH1; 33 %, DH2; 31 %, and DH3; 15 %. Recession-dependent increase in DH was observed, showing 18, 49, 52, 60, and 79 % DH-positive in teeth with 0, 1, 2, 3, and 4-8 mm recession, respectively. Plaque-free teeth showed a higher DH level than plaque-stained teeth, suggesting that good plaque control may be associated with the presence of DH. There were no significant differences in DH of teeth on the basis of smoking, probing depth, and bleeding on probing. Multiple logistic regression analysis revealed that gingival recession [odds ratio (OR) = 10.2, 95 % confidence interval (CI) = 5.5-18.9] and plaque deposition (OR = 0.3, 95 % CI = 0.2-0.5) were significant contributors to DH. Multilevel modeling analysis revealed that not only gingival recession and plaque deposition but also V-shaped cervical notch and tooth brushing frequency were associated with DH. These results demonstrate that the progression of gingival recession, plaque-free teeth, V-shaped cervical notch, and frequent brushing may be significant predictors of DH in canines and first premolars. PMID:23283584

Fukumoto, Yoshikazu; Horibe, Masumi; Inagaki, Yuji; Oishi, Keiji; Tamaki, Naofumi; Ito, Hiro-O; Nagata, Toshihiko

2014-01-01

120

Light Iceland Glacier Recession 1973 to 2000  

NSDL National Science Digital Library

This animation shows glacier recesion at the Breidamerkurjokull glacier in Iceland. The data from 1973 is taken from Landsat 1 and the 2000 data is from Landsat 7. The Breidamerkurjokull glacier in Iceland has been measured by Landsat to be receding since 1973. The glacierologists in Iceland and here at NASAs Goddard Space Flight Center have measured the recession throughout the entire glacier and found different rates of recession in different areas. In genral, the glacier seems to be receding at about 2% annually. It is extremely controversial whether or not this recession is caused by global warming.

Perkins, Lori; Hall, Dorothy

2001-04-09

121

In vitro and in vivo analysis of differential gene expression between normal norfolk terrier dogs and those with an autosomal recessive mutation in KRT10  

E-print Network

that the differentiation program in vitro underwent significant alterations. A diagnostic PCR assay was established for detection of the carrier state. Global analysis of gene expression between normal, carrier and affected dogs was performed with DermArray c...

Barnhart, Kirstin Faye

2005-11-01

122

High-throughput analysis of molecular orientation on surfaces by NEXAFS imaging of curved sample arrays.  

PubMed

Near-edge X-ray absorption fine structure (NEXAFS) spectroscopy provides detailed information about the orientation and alignment of thin films. NEXAFS is a synchrotron-based technique-the availability of beam-time per user is typically limited to no more than a few weeks per year. The limited availability is currently a true barrier for using NEXAFS in combinatorial studies of molecular alignment. We have recently demonstrated how large area full field NEXAFS imaging allows users to pursue combinatorial studies of surface chemistry. Now we report an extension of this approach which allows the acquisition of orientation information from a single NEXAFS image. An array with 80 elements (samples), containing eight series of different surface modifications, was mounted on a curved substrate allowing the collection of NEXAFS spectra with a range of orientations with respect to the X-ray beam. Images collected from this array show how hyperspectral NEXAFS data collected from curved surfaces can be used for high-throughput molecular orientation analysis. PMID:25046426

Baio, Joe E; Jaye, Cherno; Fischer, Daniel A; Weidner, Tobias

2014-09-01

123

Texture analysis and segmentation using modulation features, generative models, and weighted curve evolution.  

PubMed

In this work we approach the analysis and segmentation of natural textured images by combining ideas from image analysis and probabilistic modeling. We rely on AM-FM texture models and specifically on the Dominant Component Analysis (DCA) paradigm for feature extraction. This method provides a low-dimensional, dense and smooth descriptor, capturing essential aspects of texture, namely scale, orientation, and contrast. Our contributions are at three levels of the texture analysis and segmentation problems: First, at the feature extraction stage we propose a Regularized Demodulation Algorithm that provides more robust texture features and explore the merits of modifying the channel selection criterion of DCA. Second, we propose a probabilistic interpretation of DCA and Gabor filtering in general, in terms of Local Generative Models. Extending this point of view to edge detection facilitates the estimation of posterior probabilities for the edge and texture classes. Third, we propose the Weighted Curve Evolution scheme that enhances the Region Competition/ Geodesic Active Regions methods by allowing for the locally adaptive fusion of heterogeneous cues. Our segmentation results are evaluated on the Berkeley Segmentation Benchmark, and compare favorably to current state-of-the-art methods. PMID:19029552

Kokkinos, Iasonas; Evangelopoulos, Georgios; Maragos, Petros

2009-01-01

124

BLOT: A mesh and curve plot program for the output of a finite element analysis  

SciTech Connect

BLOT is a graphics program for post-processing of finite element analysis output that is presented in the EXODUS database format. It is command driven with free-format input and can drive any graphics device supported by the Sandia Virtual Device Interface. BLOT produces mesh plots with various representations of the analysis output variables. The major mesh plot capabilities are deformed mesh plots, line contours, banded contours, vector plots of two or three variables (e.g., velocity vectors), and symbol plots of scalar variables (e.g., temperature). Pathlines of analysis variables can also be drawn on the mesh. BLOT's features include element selection by material, element birth and death, multiple views for combining several displays on each plot, symmetry mirroring, and node and element numbering. BLOT can also produce X-Y curve plots of the analysis variables. BLOT generates time-versus-variable plots or variable-versus-variable plots. It also generates distance versus-variable plots at selected time steps where the distance is the accumulated distance between pairs of nodes or element centers. 14 refs.

Gilkey, A.P.; Glick, J.H.

1989-06-01

125

Design, analysis and test of composite curved frames for helicopter fuselage structure  

NASA Technical Reports Server (NTRS)

Curved beam effects in composite frame structures representative of a light helicopter airframe are examined, and currently available analytical methods for studying these effects are briefly reviewed. A finite element study of curved composite frames is then reported, and it is shown that the curved frame effects must be accurately accounted for to avoid premature fracture. The finite element method is shown to be accurate to within 10 percent in accounting for the curved beam effects in composite structures.

Rich, M. J.; Lowry, D. W.

1983-01-01

126

Development and analysis of vehicle trajectories and speed profiles along horizontal curves  

Microsoft Academic Search

Vehicle crashes at horizontal curves account for 42 percent of lane departure crashes on roadways. The risks of crashes on horizontal curves have been reported to be about 1.4 to 5 times greater than that for tangent sections. Twenty-five percent of the total number of fatal crashes in the United States occurred on horizontal curves. Driver error due to situational

Eric John Fitzsimmons

2011-01-01

127

Rapid prototyping and performance analysis of elliptic curve cryptographic algorithms using Java and Maple  

Microsoft Academic Search

Elliptic Curve Cryptography is an increasingly popular method of public key cryptography. It is important that these systems are made as secure as possible to known attacks. The determination of the number of points on a given elliptic curve is central to establishing whether it i s an appropriately secure curve to use. This paper describes the design, implementation and

Andrew Burnett; Tom Dowling

2004-01-01

128

Genetics Home Reference: Autosomal recessive hypotrichosis  

MedlinePLUS

... can compensate for the function of the missing protein, so not all areas with hair are affected ... condition is inherited in an autosomal recessive pattern, which means both copies of the gene in ...

129

Correlation Analysis of Optical and Radio Light Curves for a Large Sample of Active Galactic Nuclei  

NASA Astrophysics Data System (ADS)

The Rosemary Hill Observatory has accumulated internally consistent light curves extending over as much as 26 years for a large sample of active galactic nuclei. Forty-six of these optical records have been compared with similar radio records from the University of Michigan Radio Astronomy Observatory and the Algonquin Radio Observatory. For 18 objects, pairs of records were sufficiently long and unconfused to allow reliable application of the Discrete Correlation Function analysis; this group included 8 BL Lacertids, 8 quasars, and 2 Seyfert galaxies. Nine of the 18 sources showed positive radio-optical correlations, with the radio events lagging the optical by intervals ranging from 0 to 14 months. Consistent with the relativistic beaming model of the BL Lacertids, the group displaying correlations was dominated by this type of object.

Clements, S. D.; Smith, A. G.; Aller, H. D.; Aller, M. F.

1995-08-01

130

Wave propagation analysis in nonlinear curved single-walled carbon nanotubes based on nonlocal elasticity theory  

NASA Astrophysics Data System (ADS)

Theoretical predictions are presented for wave propagation in nonlinear curved single-walled carbon nanotubes (SWCNTs). Based on the nonlocal theory of elasticity, the computational model is established, combined with the effects of geometrical nonlinearity and imperfection. In order to use the wave analysis method on this topic, a linearization method is employed. Thus, the analytical expresses of the shear frequency and flexural frequency are obtained. The effects of the geometrical nonlinearity, the initial geometrical imperfection, temperature change and magnetic field on the flexural and shear wave frequencies are investigated. Numerical results indicate that the contribution of the higher-order small scale effect on the shear deformation and the rotary inertia can lead to a reduction in the frequencies compared with results reported in the published literature. The theoretical model derived in this study should be useful for characterizing the mechanical properties of carbon nanotubes and applications of nano-devices.

Wang, Bo; Deng, Zichen; Ouyang, Huajiang; Zhou, Jiaxi

2015-02-01

131

Evaluation of drug-polymer solubility curves through formal statistical analysis: comparison of preparation techniques.  

PubMed

In this study, the influence of the preparation technique (ball milling, spray drying, and film casting) of a supersaturated amorphous dispersion on the quality of solubility determinations of indomethacin in polyvinylpyrrolidone was investigated by means of statistical analysis. After annealing of the amorphous dispersions above the crystallization temperature for 2 h, the solubility curve was derived from the glass transition temperature of the demixed material using the Gordon-Taylor relationship and fitting with the Flory-Huggins model. The study showed that the predicted solubility from the ball-milled mixtures was not consistent with those from spray drying and film casting, indicating fundamental differences between the preparation techniques. Through formal statistical analysis, the best combination of fit to the Flory-Huggins model and reproducibility of the measurements was analyzed. Ball milling provided the best reproducibility of the three preparation techniques; however, an analysis of residuals revealed a systematic error. In contrast, film casting demonstrated a good fit to the model but poor reproducibility of the measurements. Therefore, this study recommends that techniques such as spray drying or potentially film casting (if experimental reproducibility can be improved) should be used to prepare the amorphous dispersions when performing solubility measurements of this kind. PMID:25363890

Knopp, Matthias Manne; Olesen, Niels Erik; Holm, Per; LÖBmann, Korbinian; Holm, RenÉ; Langguth, Peter; Rades, Thomas

2015-01-01

132

Global analysis of steady-state polarized fluorescence spectra using trilinear curve resolution.  

PubMed Central

Global analysis using trilinear curve resolution is described and shown to be a powerful method for the resolution of polarized fluorescence data arrays, in which the measured fluorescence intensity is a separable function of polarization orientation, excitation wavelength, and emission wavelength. This methodology is applicable to mixtures the components of which have linearly independent excitation and emission spectra and distinct anisotropies. Normalized excitation and emission spectra of individual components can be uniquely determined without prior assumptions concerning spectral shapes (e.g., sum of Gaussians) and without the uncertainties inherent in bilinear techniques such as principal component analysis or factor analysis. The normalized excitation and emission vectors are combined with the total absorption spectrum of the multicomponent mixture to compute absolute absorption and emission spectra. The precision of this methodology is evaluated as a function of noise, overlap, relative intensity, and anisotropy difference between components using simulated mixtures of the DNA bases. The ability of this method to extract individual spectra from steady-state fluorescence data arrays is illustrated for mixtures containing two and three components. PMID:8218915

Phillips, G R; Georghiou, S

1993-01-01

133

MOST light-curve analysis of the ? Doradus pulsator HR 8799, showing resonances and amplitude variations  

NASA Astrophysics Data System (ADS)

Context. The central star of the HR 8799 system is a ? Doradus-type pulsator. The system harbours four planetary-mass companions detected by direct imaging, and is a good solar system analogue. The masses of the companions are not accurately known because the estimation depends greatly on the age of the system, which is also not known with sufficient accuracy. Asteroseismic studies of the star might help to better constrain the age of HR 8799. We organized an extensive photometric and multi-site spectroscopic observing campaign to study the pulsations of the central star. Aims: The aim of the present study is to investigate the pulsation properties of HR 8799 in detail via the ultra-precise 47 d nearly continuous photometry obtained with the Microvariability and Oscillations in STars (MOST) space telescope, and to find as many independent pulsation modes as possible, which is the prerequisite for an asteroseismic age determination. Methods: We carried out Fourier analysis of the wide-band photometric time series. Results: We find that resonance and sudden amplitude changes characterize the pulsation of HR 8799. The dominant frequency is always at f1 = 1.978 d-1.Many multiples of one-ninth of the dominant frequency appear in the Fourier spectrum of the MOST data: n/9 f1, where n = {1,2,3,4,5,6,7,8,9,10,13,14,17,18}. Our analysis also reveals that many of these peaks show strong amplitude decrease and phase variations even on the 47 d time scale. The dependencies between the pulsation frequencies of HR 8799 make the planned subsequent asteroseismic analysis rather difficult. We point out some resemblance between the light curve of HR 8799 and the modulated pulsation light curves of Blazhko RR Lyrae stars. Based on data from the MOST satellite, a Canadian Space Agency mission, jointly operated by Dynacon Inc., the University of Toronto Institute for Aerospace Studies and the University of British Columbia, with the assistance of the University of Vienna.

Sódor, Á.; Chené, A.-N.; De Cat, P.; Bognár, Zs.; Wright, D. J.; Marois, C.; Walker, G. A. H.; Matthews, J. M.; Kallinger, T.; Rowe, J. F.; Kuschnig, R.; Guenther, D. B.; Moffat, A. F. J.; Rucinski, S. M.; Sasselov, D.; Weiss, W. W.

2014-08-01

134

Effect of recess pressure ratio on the characteristics of a hybrid bearing  

E-print Network

, recess pressure ratio, and recess to land area ratio while holding the other parameters constant. This thesis presents the theoretical and experimental characteristics for an orifice- compensated, annulus-fed hybrid water journal bearing for variation... EXPERIMEAKAL TEST FACILITY DESCRIPTION EXPE~AL PROCEDURE AND ANALYSIS . EXPERIME&KAL OBSERVATIONS 12 Prediction of Orifice Diameter Rotor Taper Frequency-Response Function RESULTS OF VARIATION IN PRESSURE RATIO 12 14 15 18 Significance of Performance...

Ingram, Michael William

2012-06-07

135

High-Resolution Melting Curve Analysis for Rapid Detection of Rifampin and Isoniazid Resistance in Mycobacterium tuberculosis Clinical Isolates ?  

PubMed Central

We evaluated high-resolution melting (HRM) curve analysis as a tool for detecting rifampin (RIF) and isoniazid (INH) resistance in Mycobacterium tuberculosis in an accurate, affordable, and rapid manner. Two hundred seventeen M. tuberculosis clinical isolates of known resistance phenotype were used. Twenty-nine known rpoB mutant DNAs, including rare mutations, were also included. Four pairs of primers were designed: rpoB-F/R (for codons 516 to 539 of rpoB), rpoB-516F/R (for codons 508 to 536 of rpoB), katG-F/R (for the codon 315 region of katG), and inhA-F/R (for the nucleotide substitution of C to T at position ?15 of inhA). An HRM curve was generated for each isolate after real-time PCR differentiated the mutant from the wild-type strains. DNA sequencing of the target regions was performed to confirm the results of the HRM curve analysis. All but one of the 73 RIF-resistant (RIF-R) strains and all 124 RIF-susceptible (RIF-S) isolates were correctly identified by HRM curve analysis of rpoB. Twenty-seven of 29 known rpoB mutants were detected. In HRM curve analysis of katG and inhA, 90 INH-R strains that harbored katG or inhA mutations, or both, and all INH-S strains were correctly identified. Ten phenotypically INH-R strains not harboring katG or inhA mutations were not detected. The HRM curve analysis will be a useful method for detection of RIF and INH resistance in M. tuberculosis in a rapid, accurate, simple, and cost-effective manner. PMID:20844231

Choi, Go Eun; Lee, Sun Min; Yi, Jongyoun; Hwang, Sang Hyun; Kim, Hyung Hoi; Lee, Eun Yup; Cho, Eun Hae; Kim, Jee Hee; Kim, Hwa-Jung; Chang, Chulhun L.

2010-01-01

136

Aetiology and Severity of Gingival Recession in an Adult Population Sample in Greece  

PubMed Central

Background: Gingival recession is the most common and undesirable condition of the gingiva. The aim of study was to investigate the aetiology and severity of gingival recession in a Greek adult population sample. Methods: The study was performed on 165 males and 179 females, 18-68 years old who sought dental treatment in a private dental practice and showed gingival recession. All subjects were clinically examined and answered questions regarding their oral hygiene habits such as the type of toothbrush, frequency of brushing and method of brushing. The association between gingival recession and the following parameters was assessed: plaque score, gingival score and tooth position. Statistical analysis of the results was accomplished using chi-square test (? = 0.05). Results: The majority (79.4%) of the patients showed grade I gingival recession and 15.3% showed grade II gingival recession. The maxillary 1st and 2nd molars (35.3%) and the mandibular 1st and 2nd molars (28.7%) were the teeth most frequently affected by root surface exposure. Patients with sub-gingival calculus, bacterial plaque and gingival inflammation (P <60; 0.05), malpositioned teeth (P <60; 0.001), horizontal brushing method, medium type of toothbrush (P <60; 0.001) and brushing once daily (P <60; 0.001) appeared to be the most common precipitating aetiological factor for gingival recession. Conclusion: According to the results of the present study, gingival recession was the result of more than one factor acting together. Horizontal brushing method, usage of medium type toothbrush and tooth brushing once daily were found to be more associated with gingival recession. PMID:22013465

Chrysanthakopoulos, Nikolaos Andreas

2011-01-01

137

Analysis and forecasting of gas well performanc: a rigorous approach using decline curve analysis  

E-print Network

, " and the application of these pseudovariables yields a rigorous equivalent solution. Presently, the analysis of gas production data is such that we must make overidealized assumptions of a constant bottomhole pressure or a constant rate. These assumptions allow us... to match the rate-time data to a theoretical model. The use of pseudovariables and, specifically, the use of pseudotime, requires knowledge of the gas- in-place, G. Without knowledge of the gas-in-place, G, we are left with a tedious and troublesome...

Palacio Uran, Juan Carlos

2012-06-07

138

Qualitative and quantitative analysis of complex temperature-programmed desorption data by multivariate curve resolution  

NASA Astrophysics Data System (ADS)

The substantial amount of information carried in temperature-programmed desorption (TPD) experiments is often difficult to mine due to the occurrence of competing reaction pathways that produce compounds with similar mass spectrometric features. Multivariate curve resolution (MCR) is introduced as a tool capable of overcoming this problem by mathematically detecting spectral variations and correlations between several m/z traces, which is later translated into the extraction of the cracking pattern and the desorption profile for each desorbate. Different from the elegant (though complex) methods currently available to analyze TPD data, MCR analysis is applicable even when no information regarding the specific surface reaction/desorption process or the nature of the desorbing species is available. However, when available, any information can be used as constraints that guide the outcome, increasing the accuracy of the resolution. This approach is especially valuable when the compounds desorbing are different from what would be expected based on a chemical intuition, when the cracking pattern of the model test compound is difficult or impossible to obtain (because it could be unstable or very rare), and when knowing major components desorbing from the surface could in more traditional methods actually bias the quantification of minor components. The enhanced level of understanding of thermal processes achieved through MCR analysis is demonstrated by analyzing three phenomena: i) the cryogenic desorption of vinyltrimethylsilane from silicon, an introductory system where the known multilayer and monolayer components are resolved; ii) acrolein hydrogenation on a bimetallic Pt-Ni-Pt catalyst, where a rapid identification of hydrogenated products as well as other desorbing species is achieved, and iii) the thermal reaction of Ti[N(CH 3) 2] 4 on Si(100), where the products of surface decomposition are identified and an estimation of the surface composition after the thermal reaction is afforded. Since this work constitutes, to the best of our knowledge, the first effort to introduce multivariate analysis to TPD data, the procedures, algorithms and strategies employed are described in full detail.

Rodríguez-Reyes, Juan Carlos F.; Teplyakov, Andrew V.; Brown, Steven D.

2010-10-01

139

International Planetary Patrol observations of Saturn's rings. II. Four color phase curves and their analysis  

Microsoft Academic Search

New phase curves for Saturn's rings at an intermediate tilt angle B approx.17 ° are presented. Quantitative results for each of the A and B rings are reported in terms of the opposition effect, phase coefficient, and best logarithmic fit to the phase curve. In each of the four colors, there is no significant difference between the shape of the

L. W. Esposito; K. Lumme; W. D. Benton; L. J. Martin; H. M. Ferguson; D. T. Thompson; S. E. Jones

1979-01-01

140

Product Differentiation by Analysis of DNA Melting Curves during the Polymerase Chain Reaction  

Microsoft Academic Search

A microvolume fluorometer integrated with a thermal cycler was used to acquire DNA melting curves during polymerase chain reaction by fluorescence monitoring of the double-stranded DNA specific dye SYBR Green I. Plotting fluorescence as a function of temperature as the thermal cycler heats through the dissociation temperature of the product gives a DNA melting curve. The shape and position of

Kirk M. Ririe; Randy P. Rasmussen; Carl T. Wittwer

1997-01-01

141

Dynamic Beveridge and Phillips curves: A macroeconometric analysis of the US labor market  

Microsoft Academic Search

This paper addresses the question how monetary policy shocks and technology shocks affect the US labor market. Focus is on the dynamics of conditional Beveridge and Phillips curves. Conditional correlations reveal that it is mainly the monetary shock that generates the negative slopes of the Beveridge and Phillips curves. The technology shock adds somewhat to the slope of the Beveridge

Sebastian Watzka

142

The Obsessive Compulsive Scale of the Child Behavior Checklist Predicts Obsessive-Compulsive Disorder: A Receiver Operating Characteristic Curve Analysis  

ERIC Educational Resources Information Center

Background: The purpose of this study was to determine a score on the Obsessive Compulsive Scale (OCS) from the Child Behavior Checklist (CBCL) to screen for obsessive compulsive disorder (OCD) in children and to rigorously test the specificity and sensitivity of a single cutpoint. Methods: A receiver operating characteristic (ROC) curve analysis

Hudziak, James J.; Althoff, Robert R.; Stanger, Catherine; van Beijsterveldt, C. E. M.; Nelson, Elliot C.; Hanna, Gregory L.; Boomsma, Dorret I.; Todd, Richard D.

2006-01-01

143

The Obsessive Compulsive Scale of the Child Behavior Checklist predicts obsessive-compulsive disorder: a receiver operating characteristic curve analysis  

Microsoft Academic Search

Background: The purpose of this study was to determine a score on the Obsessive Compulsive Scale (OCS) from the Child Behavior Checklist (CBCL) to screen for obsessive compulsive disorder (OCD) in children and to rigorously test the specificity and sensitivity of a single cutpoint. Methods: A receiver operating characteristic (ROC) curve analysis was applied to data from 61 patients with

James J. Hudziak; Robert R. Althoff; Catherine Stanger; Beijsterveldt van C. E. M; Elliot C. Nelson; Gregory L. Hanna; Dorret I. Boomsma; Richard D. Todd

2006-01-01

144

Mixed models defined by stochastic differential equations 1 Bayesian analysis of growth curves using mixed models defined by stochastic  

E-print Network

Mixed models defined by stochastic differential equations 1 Bayesian analysis of growth curves using mixed models defined by stochastic differential equations Sophie Donnet1 Ceremade, Universite are classically analyzed by nonlinear mixed models. However, the standard growth functions used in this context

Paris-Sud XI, Université de

145

Development of synthetic velocity - depth damage curves using a Weighted Monte Carlo method and Logistic Regression analysis  

NASA Astrophysics Data System (ADS)

Damage curves are the most significant component of the flood loss estimation models. Their development is quite complex. Two types of damage curves exist, historical and synthetic curves. Historical curves are developed from historical loss data from actual flood events. However, due to the scarcity of historical data, synthetic damage curves can be alternatively developed. Synthetic curves rely on the analysis of expected damage under certain hypothetical flooding conditions. A synthetic approach was developed and presented in this work for the development of damage curves, which are subsequently used as the basic input to a flood loss estimation model. A questionnaire-based survey took place among practicing and research agronomists, in order to generate rural loss data based on the responders' loss estimates, for several flood condition scenarios. In addition, a similar questionnaire-based survey took place among building experts, i.e. civil engineers and architects, in order to generate loss data for the urban sector. By answering the questionnaire, the experts were in essence expressing their opinion on how damage to various crop types or building types is related to a range of values of flood inundation parameters, such as floodwater depth and velocity. However, the loss data compiled from the completed questionnaires were not sufficient for the construction of workable damage curves; to overcome this problem, a Weighted Monte Carlo method was implemented, in order to generate extra synthetic datasets with statistical properties identical to those of the questionnaire-based data. The data generated by the Weighted Monte Carlo method were processed via Logistic Regression techniques in order to develop accurate logistic damage curves for the rural and the urban sectors. A Python-based code was developed, which combines the Weighted Monte Carlo method and the Logistic Regression analysis into a single code (WMCLR Python code). Each WMCLR code execution provided a flow velocity-depth damage curve for a specific land use. More specifically, each WMCLR code execution for the agricultural sector generated a damage curve for a specific crop and for every month of the year, thus relating the damage to any crop with floodwater depth, flow velocity and the growth phase of the crop at the time of flooding. Respectively, each WMCLR code execution for the urban sector developed a damage curve for a specific building type, relating structural damage with floodwater depth and velocity. Furthermore, two techno-economic models were developed in Python programming language, in order to estimate monetary values of flood damages to the rural and the urban sector, respectively. A new Monte Carlo simulation was performed, consisting of multiple executions of the techno-economic code, which generated multiple damage cost estimates. Each execution used the proper WMCLR simulated damage curve. The uncertainty analysis of the damage estimates established the accuracy and reliability of the proposed methodology for the synthetic damage curves' development.

Vozinaki, Anthi Eirini K.; Karatzas, George P.; Sibetheros, Ioannis A.; Varouchakis, Emmanouil A.

2014-05-01

146

Growth curve analysis for plasma profiles using smoothing splines. Annual progress report, June 1992--June 1993  

SciTech Connect

We are developing a profile analysis code for the statistical estimation of the parametric dependencies of the temperature and density profiles in tokamaks. Our code uses advanced statistical techniques to determine the optimal fit, i.e. the fit which minimized the predictive error. For a forty TFTR Ohmic profile dataset, our preliminary results indicate that the profile shape depends almost exclusively on q{sub a}{prime} but that the shape dependencies are not Gaussian. We are now comparing various shape models on the TFTR data. In the first six months, we have completed the core modules of the code, including a B-spline package for variable knot locations, a data-based method to determine the optimal smoothing parameters, self-consistent estimation of the bias errors, and adaptive fitting near the plasma edge. Visualization graphics already include three dimensional surface plots, and discharge by discharge plots of the predicted curves with error bars together with the actual measurements values, and plots of the basis functions with errors.

Imre, K.

1993-05-01

147

Cognitive Vulnerabilities and Depression in Young Adults: An ROC Curves Analysis.  

PubMed

Objectives and Methods. The aim of the present study was to evaluate, by means of receiver operating characteristic (ROC) curves, whether cognitive vulnerabilities (CV), as measured by three well-known instruments (the Beck Hopelessness Scale, BHS; the Life Orientation Test-Revised, LOT-R; and the Attitudes Toward Self-Revised, ATS-R), independently discriminate between subjects with different severities of depression. Participants were 467 young adults (336 females and 131 males), recruited from the general population. The subjects were also administered the Beck Depression Inventory-II (BDI-II). Results. Four first-order (BHS Optimism/Low Standard; BHS Pessimism; Generalized Self-Criticism; and LOT Optimism) and two higher-order factors (Pessimism/Negative Attitudes Toward Self, Optimism) were extracted using Principal Axis Factoring analysis. Although all first-order and second-order factors were able to discriminate individuals with different depression severities, the Pessimism factor had the best performance in discriminating individuals with moderate to severe depression from those with lower depression severity. Conclusion. In the screening of young adults at risk of depression, clinicians have to pay particular attention to the expression of pessimism about the future. PMID:24058734

Balsamo, Michela; Imperatori, Claudio; Sergi, Maria Rita; Belvederi Murri, Martino; Continisio, Massimo; Tamburello, Antonino; Innamorati, Marco; Saggino, Aristide

2013-01-01

148

Cognitive Vulnerabilities and Depression in Young Adults: An ROC Curves Analysis  

PubMed Central

Objectives and Methods. The aim of the present study was to evaluate, by means of receiver operating characteristic (ROC) curves, whether cognitive vulnerabilities (CV), as measured by three well-known instruments (the Beck Hopelessness Scale, BHS; the Life Orientation Test-Revised, LOT-R; and the Attitudes Toward Self-Revised, ATS-R), independently discriminate between subjects with different severities of depression. Participants were 467 young adults (336 females and 131 males), recruited from the general population. The subjects were also administered the Beck Depression Inventory-II (BDI-II). Results. Four first-order (BHS Optimism/Low Standard; BHS Pessimism; Generalized Self-Criticism; and LOT Optimism) and two higher-order factors (Pessimism/Negative Attitudes Toward Self, Optimism) were extracted using Principal Axis Factoring analysis. Although all first-order and second-order factors were able to discriminate individuals with different depression severities, the Pessimism factor had the best performance in discriminating individuals with moderate to severe depression from those with lower depression severity. Conclusion. In the screening of young adults at risk of depression, clinicians have to pay particular attention to the expression of pessimism about the future. PMID:24058734

Sergi, Maria Rita; Continisio, Massimo; Tamburello, Antonino; Innamorati, Marco; Saggino, Aristide

2013-01-01

149

Analysis of Curved Sandwich Panels Subjected to Combined Temperature Gradient and Mechanical Loads  

NASA Technical Reports Server (NTRS)

The results of a detailed study of the nonlinear response of curved sandwich panels with composite face sheets and subjected to a temperature gradient through-the-thickness combined with mechanical loadings are presented. The analysis is based on a first-order shear-deformation Sanders-Budiansky type theory with the effects of large displacements, moderate rotations, transverse shear deformation and laminated anisotropic material behavior included. A mixed formulation is used with the fundamental unknowns consisting of the generalized displacements and the stress resultants of the panel. The nonlinear displacements, strain energy, principal strains, transverse shear stresses, transverse shear strain energy density, and their hierarchical sensitivity coefficients are evaluated. The hierarchical sensitivity coefficients measure the sensitivity of the nonlinear response to variations in the panel parameters, the effective properties of the face sheet layers and the core, and the micromechanical parameters. Numerical results are presented for cylindrical panels subjected to combined pressure loading, edge shortening or extension, edge shear and a temperature gradient through the thickness. The results show the effects of variations in the loading and the panel aspect ratio, on the nonlinear response and its sensitivity to changes in the various panel, effective layer and micromechanical parameters.

Noor, Ahmed K.; Starnes, James H., Jr.; Peters, Jeanne M.

1998-01-01

150

M DWARFS IN SLOAN DIGITAL SKY SURVEY STRIPE 82: PHOTOMETRIC LIGHT CURVES AND FLARE RATE ANALYSIS  

SciTech Connect

We present a flare rate analysis of 50,130 M dwarf light curves in Sloan Digital Sky Survey Stripe 82. We identified 271 flares using a customized variability index to search {approx}2.5 million photometric observations for flux increases in the u and g bands. Every image of a flaring observation was examined by eye and with a point-spread function-matching and image subtraction tool to guard against false positives. Flaring is found to be strongly correlated with the appearance of H{alpha} in emission in the quiet spectrum. Of the 99 flare stars that have spectra, we classify eight as relatively inactive. The flaring fraction is found to increase strongly in stars with redder colors during quiescence, which can be attributed to the increasing flare visibility and increasing active fraction for redder stars. The flaring fraction is strongly correlated with |Z| distance such that most stars that flare are within 300 pc of the Galactic plane. We derive flare u-band luminosities and find that the most luminous flares occur on the earlier-type m dwarfs. Our best estimate of the lower limit on the flaring rate (averaged over Stripe 82) for flares with {delta}u {>=} 0.7 mag on stars with u < 22 is 1.3 flares hr{sup -1} deg{sup -2} but can vary significantly with the line of sight.

Kowalski, Adam F.; Hawley, Suzanne L.; Hilton, Eric J.; Becker, Andrew C.; Sesar, Branimir [Astronomy Department, University of Washington, Box 351580, Seattle, WA 98195 (United States); West, Andrew A.; Bochanski, John J. [MIT Kavli Institute for Astrophysics and Space Research, 77 Massachusetts Avenue, Building 37, Cambridge, MA 02139 (United States)], E-mail: kowalski@astro.washington.edu

2009-08-15

151

Unsteady incompressible flow analysis using C-type grid with a curved branch cut  

NASA Astrophysics Data System (ADS)

For an unsteady viscous flow simulation on a two-dimensional body at high angle of attack, the calculation of unsteady aerodynamic forces acting on the body is influenced not only by the unsteady separated flow near the body but also by the unsteady wake behind the body. To resolve the wake flow behind the trailing edge, an orthogonal C-grid topology with a curved branch cut aligned with the inviscid stagnation streamline is generated using a conformal mapping technique. This permits the desired grid clustering in the wake region and leads to better flow results in that region. The conformal mapping technique also provides analytical Jacobian metrics for the coordinate transformation and an inviscid solution which is useful in initiating the viscous flow of the impulsively started motion. The use of analytical metric coefficients facilitates the direct determination of part of the coefficients in the governing equations without introducing numerical errors. The unsteady two-dimensional incompressible Navier-Stokes equations in generalized orthogonal coordinates are solved using a vorticity-stream function formulation. The analysis also requires coupling of flow circulation in the far field. As a result, the vorticity-stream function formulation introduced in the present study contains the spatially elliptic equation for the disturbance stream function coupled with the temporally parabolic vorticity transport equation. An efficient direct Block-Gaussian Elimination (BGE) technique is used to solve the stream function Poisson problem subject to Neumann and Dirichlet boundary conditions. The vorticity transport equation is solved using the Alternating Direct Implicit (ADI) method. In addition, the Jacobian at the grid points along the curved branch cut is multi-valued and the metric coefficients are found to be discontinuous across the branch cut. Hence, a special finite element interpolation is implemented in the governing equations at those points in order to overcome this discontinuity. To achieve the objective stated above, the unsteady flow over a stationary NACA 0015 airfoil at various angles of attack is selected in the present study.

Fang, Kuan-Chieh

2000-08-01

152

Re-Analysis of the Solar Phase Curves of the Icy Galilean Satellites  

NASA Technical Reports Server (NTRS)

Re-analysis of the solar phase curves of the icy Galilean satellites demonstrates that the quantitative results are dependent on the single particle scattering function incorporated into the photometric model; however, the qualitative properties are independent. The results presented here show that the general physical characteristics predicted by a Hapke model (B. Hapke, 1986, Icarus 67, 264-280) incorporating a two parameter double Henyey-Greenstein scattering function are similar to the predictions given by the same model incorporating a three parameter double Henyey-Greenstein scattering function as long as the data set being modeled has adequate coverage in phase angle. Conflicting results occur when the large phase angle coverage is inadequate. Analysis of the role of isotropic versus anisotropic multiple scattering shows that for surfaces as bright as Europa the two models predict very similar results over phase angles covered by the data. Differences arise only at those phase angles for which there are no data. The single particle scattering behavior between the leading and trailing hemispheres of Europa and Ganymede is commensurate with magnetospheric alterations of their surfaces. Ion bombardment will produce more forward scattering single scattering functions due to annealing of potential scattering centers within regolith particles (N. J. Sack et al., 1992, Icarus 100, 534-540). Both leading and trailing hemispheres of Europa are consistent with a high porosity model and commensurate with a frost surface. There are no strong differences in predicted porosity between the two hemispheres of Callisto, both are consistent with model porosities midway between that deduced for Europa and the Moon. Surface roughness model estimates predict that surface roughness increases with satellite distance from Jupiter, with lunar surface roughness values falling midway between those measured for Ganymede and Callisto. There is no obvious variation in predicted surface roughness with hemisphere for any of the Galilean satellites.

Domingue, Deborah; Verbiscer, Anne

1997-01-01

153

Spectral variations and a classical curve-of-growth analysis of HDE 226868 (Cyg X-1).  

NASA Astrophysics Data System (ADS)

The authors present an analysis of high resolution (R ˜ 17000) echelle spectra in the wavelength range 3200 to 6800 Å obtained at the Observatorio Astronómico Nacional at San Pedro Mártir, of HDE 226868, the optical component of the Cyg X-1 binary system. Empirical radial velocity vs. excitation (RV vs. E) relations are obtained from the spectra at 7 orbital phases and the slope (A) of these relations is found to vary, having two extrema: -0.30 km s-1eV-1 near phase 0.5 (collapsed object "in front") and -0.22 km s-1eV-1 near phase 0.0. At other phases the value is A = -0.13 km s-1eV-1. This variability in the slope of the RV vs. E relation is in very good agreement with the theoretically predicted anisotropic mass-loss rates resulting from the modified gravitational potential of the system (Friend and Castor, 1982) for the case in which the primary star fills its Roche lobe. Variations at the 25% level in the shapes and strengths of H? and He I photospheric absorption lines are detected. The variability of the absorption line profiles appears to correlate with the H? and the He II 4686 Å emission line variations, suggesting that the absorption lines are contaminated by variable emission components. From a classical curve-of-growth analysis HDE 226868 is found to have Texc = 32100±1600° K, and to be overabundant in He and underabundant in C with respect to the B0 Ia supergiant ? Ori.

Canalizo, G.; Koenigsberger, G.; Peña, D.; Ruiz, E.

1995-04-01

154

Glacier recession in Iceland and Austria  

SciTech Connect

It has been possible to measure glacier recession on the basis of Landsat data, in conjunction with comparisons of the magnitude of recession of a glacier margin with in situ measurements at fixed points along the same margin. Attention is presently given to the cases of Vatnajokull ice cap, in Iceland, and the Pasterze Glacier, in Austria, on the basis of satellite data from 1973-1987 and 1984-1990, respectively. Indications of a trend toward negative mass balance are noted. Nevertheless, while most of the world's small glaciers have been receding, some are advancing either due to local climate or the tidewater glacier cycle. 21 refs.

Hall, D.K.; Williams, R.S. Jr.; Bayr, K.J. (NASA, Goddard Space Flight Center, Greenbelt, MD (United States) USGS, Reston, VA (United States) Keene State College, NH (United States))

1992-03-01

155

Glacier recession in Iceland and Austria  

NASA Technical Reports Server (NTRS)

It has been possible to measure glacier recession on the basis of Landsat data, in conjunction with comparisons of the magnitude of recession of a glacier margin with in situ measurements at fixed points along the same margin. Attention is presently given to the cases of Vatnajokull ice cap, in Iceland, and the Pasterze Glacier, in Austria, on the basis of satellite data from 1973-1987 and 1984-1990, respectively. Indications of a trend toward negative mass balance are noted. Nevertheless, while most of the world's small glaciers have been receding, some are advancing either due to local climate or the tidewater glacier cycle.

Hall, Dorothy K.; Williams, Richard S., Jr.; Bayr, Klaus J.

1992-01-01

156

BEER Analysis of Kepler and CoRoT Light Curves. II. Evidence for Superrotation in the Phase Curves of Three Kepler Hot Jupiters  

NASA Astrophysics Data System (ADS)

We analyzed the Kepler light curves of four transiting hot Jupiter systems—KOI-13, HAT-P-7, TrES-2, and Kepler-76, which show BEaming, Ellipsoidal, and Reflection (BEER) phase modulations. The mass of the four planets can be estimated from either the beaming or the ellipsoidal amplitude, given the mass and radius of their parent stars. For KOI-13, HAT-P-7, and Kepler-76 we find that the beaming-based planetary mass estimate is larger than the mass estimated from the ellipsoidal amplitude, consistent with previous studies. This apparent discrepancy may be explained by equatorial superrotation of the planet atmosphere, which induces an angle shift of the planet reflection/emission phase modulation, as was suggested for Kepler-76 in the first paper of this series. We propose a modified BEER model that supports superrotation, assuming either a Lambertian or geometric reflection/emission phase function, and provides a photometry-consistent estimate of the planetary mass. Our analysis shows that for Kepler-76 and HAT-P-7, the Lambertian superrotation BEER model is highly preferable over an unshifted null model, while for KOI-13 it is preferable only at a 1.4? level. For TrES-2 we do not find such preference. For all four systems the Lambertian superrotation model mass estimates are in excellent agreement with the planetary masses derived from, or constrained by, radial velocity measurements. This makes the Lambertian superrotation BEER model a viable tool for estimating the masses of hot Jupiters from photometry alone. We conclude that hot Jupiter superrotation may be a common phenomenon that can be detected in the visual light curves of Kepler.

Faigler, S.; Mazeh, T.

2015-02-01

157

Application of multivariate curve resolution alternating least squares (MCR-ALS) to the quantitative analysis of pharmaceutical and agricultural samples  

Microsoft Academic Search

Application of multivariate curve resolution alternating least squares (MCR-ALS), for the resolution and quantification of different analytes in different type of pharmaceutical and agricultural samples is shown. In particular, MCR-ALS is applied first to the UV spectrophotometric quantitative analysis of mixtures of commercial steroid drugs, and second to the near-infrared (NIR) spectrophotometric quantitative analysis of humidity and protein contents in

T. Azzouz; R. Tauler

2008-01-01

158

Detecting molecular separation in nano-fluidic channels through velocity analysis of temporal image sequences by multivariate curve resolution  

Microsoft Academic Search

In this study, we report on a method of determining individual velocities of molecular species being separated in a fluid\\u000a medium within array of nanofluidic channels that can be useful in the detection of molecular species. The method is based\\u000a on the application of multivariate image analysis methods, in this case principal component analysis and multivariate curve\\u000a resolution, to temporal

Kateryna ArtyushkovaAnthony; Anthony L. Garcia; Gabriel P. Lõpez

2010-01-01

159

Evaluation of qPCR curve analysis methods for reliable biomarker discovery: bias, resolution, precision, and implications.  

PubMed

RNA transcripts such as mRNA or microRNA are frequently used as biomarkers to determine disease state or response to therapy. Reverse transcription (RT) in combination with quantitative PCR (qPCR) has become the method of choice to quantify small amounts of such RNA molecules. In parallel with the democratization of RT-qPCR and its increasing use in biomedical research or biomarker discovery, we witnessed a growth in the number of gene expression data analysis methods. Most of these methods are based on the principle that the position of the amplification curve with respect to the cycle-axis is a measure for the initial target quantity: the later the curve, the lower the target quantity. However, most methods differ in the mathematical algorithms used to determine this position, as well as in the way the efficiency of the PCR reaction (the fold increase of product per cycle) is determined and applied in the calculations. Moreover, there is dispute about whether the PCR efficiency is constant or continuously decreasing. Together this has lead to the development of different methods to analyze amplification curves. In published comparisons of these methods, available algorithms were typically applied in a restricted or outdated way, which does not do them justice. Therefore, we aimed at development of a framework for robust and unbiased assessment of curve analysis performance whereby various publicly available curve analysis methods were thoroughly compared using a previously published large clinical data set (Vermeulen et al., 2009) [11]. The original developers of these methods applied their algorithms and are co-author on this study. We assessed the curve analysis methods' impact on transcriptional biomarker identification in terms of expression level, statistical significance, and patient-classification accuracy. The concentration series per gene, together with data sets from unpublished technical performance experiments, were analyzed in order to assess the algorithms' precision, bias, and resolution. While large differences exist between methods when considering the technical performance experiments, most methods perform relatively well on the biomarker data. The data and the analysis results per method are made available to serve as benchmark for further development and evaluation of qPCR curve analysis methods (http://qPCRDataMethods.hfrc.nl). PMID:22975077

Ruijter, Jan M; Pfaffl, Michael W; Zhao, Sheng; Spiess, Andrej N; Boggy, Gregory; Blom, Jochen; Rutledge, Robert G; Sisti, Davide; Lievens, Antoon; De Preter, Katleen; Derveaux, Stefaan; Hellemans, Jan; Vandesompele, Jo

2013-01-01

160

Ogive Curves  

NSDL National Science Digital Library

This page contains a discussion of ogive curves, logistic regression curves, and architecture. Nice photographs of architectural applications are included. The classic Birthday Problems is included as an example of an ogive curve.

2008-01-01

161

Combined statistical analysis of vasodilation and flow curves in brachial ultrasonography: technique and its connection to cardiovascular risk factors  

NASA Astrophysics Data System (ADS)

Clinical studies report that impaired endothelial function is associated with Cardio-Vascular Diseases (CVD) and their risk factors. One commonly used mean for assessing endothelial function is Flow-Mediated Dilation (FMD). Classically, FMD is quantified using local indexes e.g. maximum peak dilation. Although such parameters have been successfully linked to CVD risk factors and other clinical variables, this description does not consider all the information contained in the complete vasodilation curve. Moreover, the relation between flow impulse and the vessel vasodilation response to this stimulus, although not clearly known, seems to be important and is not taken into account in the majority of studies. In this paper we propose a novel global parameterization for the vasodilation and the flow curves of a FMD test. This parameterization uses Principal Component Analysis (PCA) to describe independently and jointly the variability of flow and FMD curves. These curves are obtained using computerized techniques (based on edge detection and image registration, respectively) to analyze the ultrasound image sequences. The global description obtained through PCA yields a detailed characterization of the morphology of such curves allowing the extraction of intuitive quantitative information of the vasodilation process and its interplay with flow changes. This parameterization is consistent with traditional measurements and, in a database of 177 subjects, seems to correlate more strongly (and with more clinical parameters) than classical measures to CVD risk factors and clinical parameters such as LDL- and HDL-Cholesterol.

Boisrobert, Loic; Laclaustra, Martin; Bossa, Matias; Frangi, Andres G.; Frangi, Alejandro F.

2005-04-01

162

International planetary patrol observations of Saturn's rings. II - Four color phase curves and their analysis  

NASA Technical Reports Server (NTRS)

New phase curves for Saturn's rings at an intermediate tilt angle B of about 17 deg are presented. Quantitative results for each of the A and B rings are reported in terms of the opposition effect, phase coefficient, and best logarithmic fit to the phase curve. There was no significant difference between the shape of the phase curves for the two rings in each of the four colors, and a four-parameter multiple scattering model of the rings was consistent with the observations. In this model, the difference in the phase curves for different colors can be explained by a variation in the single scattering albedo with wavelength. The observations allow the particles to have the same composition in the A and B rings, so that their different photometric behavior is explained by differences in optical depth and volume density in the two rings.

Esposito, L. W.; Lumme, K.; Benton, W. D.; Martin, L. J.; Ferguson, H. M.; Thompson, D. T.; Jones, S. E.

1979-01-01

163

High-Throughput Genome Editing and Phenotyping Facilitated by High Resolution Melting Curve Analysis  

PubMed Central

With the goal to generate and characterize the phenotypes of null alleles in all genes within an organism and the recent advances in custom nucleases, genome editing limitations have moved from mutation generation to mutation detection. We previously demonstrated that High Resolution Melting (HRM) analysis is a rapid and efficient means of genotyping known zebrafish mutants. Here we establish optimized conditions for HRM based detection of novel mutant alleles. Using these conditions, we demonstrate that HRM is highly efficient at mutation detection across multiple genome editing platforms (ZFNs, TALENs, and CRISPRs); we observed nuclease generated HRM positive targeting in 1 of 6 (16%) open pool derived ZFNs, 14 of 23 (60%) TALENs, and 58 of 77 (75%) CRISPR nucleases. Successful targeting, based on HRM of G0 embryos correlates well with successful germline transmission (46 of 47 nucleases); yet, surprisingly mutations in the somatic tail DNA weakly correlate with mutations in the germline F1 progeny DNA. This suggests that analysis of G0 tail DNA is a good indicator of the efficiency of the nuclease, but not necessarily a good indicator of germline alleles that will be present in the F1s. However, we demonstrate that small amplicon HRM curve profiles of F1 progeny DNA can be used to differentiate between specific mutant alleles, facilitating rare allele identification and isolation; and that HRM is a powerful technique for screening possible off-target mutations that may be generated by the nucleases. Our data suggest that micro-homology based alternative NHEJ repair is primarily utilized in the generation of CRISPR mutant alleles and allows us to predict likelihood of generating a null allele. Lastly, we demonstrate that HRM can be used to quickly distinguish genotype-phenotype correlations within F1 embryos derived from G0 intercrosses. Together these data indicate that custom nucleases, in conjunction with the ease and speed of HRM, will facilitate future high-throughput mutation generation and analysis needed to establish mutants in all genes of an organism. PMID:25503746

Thomas, Holly R.; Percival, Stefanie M.; Yoder, Bradley K.; Parant, John M.

2014-01-01

164

Curved Glide-Reflection Symmetry Detection,” Transactions on Pattern Analysis and  

E-print Network

Abstract—We generalize the concept of bilateral reflection symmetry to curved glide-reflection symmetry in 2D euclidean space, such that classic reflection symmetry becomes one of its six special cases. We propose a local feature-based approach for curved glidereflection symmetry detection from real, unsegmented 2D images. Furthermore, we apply curved glide-reflection axis detection for curved reflection surface detection in 3D images. Our method discovers, groups, and connects statistically dominant local glidereflection axes in an Axis-Parameter-Space (APS) without preassumptions on the types of reflection symmetries. Quantitative evaluations and comparisons against state-of-the-art algorithms on a diverse 64-test-image set and 1,125 Swedish leaf-data images show a promising average detection rate of the proposed algorithm at 80 and 40 percent, respectively, and superior performance over existing reflection symmetry detection algorithms. Potential applications in computer vision, particularly biomedical imaging, include saliency detection from unsegmented images and quantification of deviations from normality. We make our 64-test-image set publicly available. Index Terms—Symmetry, glide reflection, curved axis, curved surface. Ç 1

Seungkyu Lee; Yanxi Liu; Senior Member

2012-01-01

165

Analysis of Late--time Light Curves of Type IIb, Ib and Ic Supernovae  

E-print Network

The shape of the light curve peak of radioactive-powered core-collapse "stripped-envelope," supernovae constrains the ejecta mass, nickel mass, and kinetic energy by the brightness and diffusion time for a given opacity and observed expansion velocity. Late-time light curves give constraints on the same parameters, given the gamma-ray opacity. Previous work has shown that the principal light curve peaks for SN IIb with small amounts of hydrogen and for hydrogen/helium-deficient SN Ib/c are often rather similar near maximum light, suggesting similar ejecta masses and kinetic energies, but that late-time light curves show a wide dispersion, suggesting a dispersion in ejecta masses and kinetic energies. It was also shown that SN IIb and SN Ib/c can have very similar late-time light curves, but different ejecta velocities demanding significantly different ejecta masses and kinetic energies. We revisit these topics by collecting and analyzing well-sampled single color and quasi-bolometric light curves from the lit...

Wheeler, J Craig; Clocchiatti, A

2014-01-01

166

Radial recession osteotomy for early Kienböck's disease  

Microsoft Academic Search

Between 1995 and 1999, ten patients with Lichtman stage II and III Kienböck's disease with negative ulnar variance underwent a joint-levelling radial recession osteotomy in our unit. The procedure was performed by the senior author in all cases. Eight patients were available for follow-up (average 31 months). Based on the Mayo Clinic modification of the Green wrist score, there were

A. J. Laing; B. Lenehan; T. Oh; M. O'Sullivan

2002-01-01

167

Weathering the Recession in College Health  

ERIC Educational Resources Information Center

The current global recession has increased personal stress levels throughout our society. With dwindling resources, institutions of higher learning are especially prone to budgetary cutbacks during such periods. Based on 22 years of experience as a health service director, the author offers some personal insights in the hope that they will help…

Christmas, William A.

2010-01-01

168

Nevada, the Great Recession, and Education  

ERIC Educational Resources Information Center

The impact of the Great Recession and its aftermath has been devastating in Nevada, especially for public education. This article discusses the budget shortfalls and the impact of the economic crisis in Nevada using case study methodology. It provides a review of documents, including Governor Gibbon's proposals for the public K-12 education system…

Verstegen, Deborah A.

2013-01-01

169

Drilldown on Poverty and the Recession  

E-print Network

Drilldown on Poverty and the Recession Working Paper Prepared by Lois M. Quinn Employment analyzes recently released 1-year estimates of poverty and economic conditions data from the U.S. Census bases to help residents and public officials address concerns related to poverty, employment

Saldin, Dilano

170

The Recession and Education: Seize New Opportunities!  

ERIC Educational Resources Information Center

The teaching profession has long been thought of as recession proof. Indeed, that may have been one of the reasons why teachers took far lower starting salaries right out of college. Perhaps the greatest common feature of teachers, besides their desire to serve society in a humanitarian way, may be the lack of risk-taking the occupation previously…

Haskvitz, Alan

2011-01-01

171

Reclaiming Recess: Learning the Language of Persuasion  

ERIC Educational Resources Information Center

Using a case study approach, the authors describe how a teacher used the tools of systemic functional linguistics (SFL) to teach her fifth grade English Language Learners how to use academic language to challenge school policies regarding recess. In reflecting on these data, we discuss the potential of SFL to support teachers in responding to…

Gebhard, Meg; Harman, Ruth; Seger, Wendy

2007-01-01

172

Analysis of tracer tomography using temporal moments of tracer breakthrough curves  

NASA Astrophysics Data System (ADS)

Hydraulic/partitioning tracer tomography (HPTT) was recently developed by Yeh and Zhu [Yeh T-CJ, Zhu J. Hydraulic/partitioning tracer tomography for characterization of dense nonaqueous phase liquid source zones, Water Resour Res 2007;43:W06435. doi:10.1029/2006WR004877.] for estimating spatial distribution of dense nonaqueous phase liquids (DNAPLs) in the subsurface. Since discrete tracer concentration data are directly utilized for the estimation of DNAPLs, this approach solves the hyperbolic convection-dispersion equation. Solution to the convection-dispersion equation however demands fine temporal and spatial discretization, resulting in high computational cost for an HPTT analysis. In this work, we use temporal moments of tracer breakthrough curves instead of discrete concentration data to estimate DNAPL distribution. This approach solves time independent partial differential equations of the temporal moments, and therefore avoids solving the convection-dispersion equation using a time marching scheme, resulting in a dramatic reduction of computational cost. To reduce numerical oscillations associated with convection dominated transport problems such as in inter-well tracer tests, the approach uses a finite element solver adopting the streamline upwind Petrov-Galerkin method to calculate moments and sensitivities. We test the temporal moment approach through numerical simulations. Comparing the computational costs between utilizing moments and discrete concentrations, we find that temporal moments significantly reduce the computation time. We also find that tracer moment data collected through a tomographic survey alone are able to yield reasonable estimates of hydraulic conductivity, as indicated by a correlation of 0.588 between estimated and true hydraulic conductivity fields in the synthetic case study.

Zhu, Junfeng; Cai, Xing; Jim Yeh, Tian-Chyi

2009-03-01

173

SACCHAROMYCES CEREVISIAE Recessive Suppressor That Circumvents Phosphatidylserine Deficiency  

PubMed Central

Phenotypic reversion of six independent Saccharomyces cerevisiae cho1 mutants was shown to be due predominantly to mutation of an unlinked gene, eam1. The eam1 gene was located very close to ino1 on chromosome X by meiotic tetrad analysis. Recessive eam1 mutations did not correct the primary cho1 defect in phosphatidylserine synthesis but made endogenous ethanolamine available for sustained nitrogenous phospholipid synthesis. A novel biochemical contribution to nitrogenous lipid synthesis is indicated by the eam1 mutants. PMID:17246236

Atkinson, Katharine D.

1984-01-01

174

An analysis of the shapes of ultraviolet extinction curves. II - The far-UV extinction  

NASA Technical Reports Server (NTRS)

In this paper the properties of interstellar extinction in the far-ultraviolet region are examined utilizing IUE extinction curves for a primary data sample of 45 reddened Milky Way OB stars. These results are combined with those derived for the 2175 A bump in a previous study. It is found that IUE extinction curves can be represented by linear combinations of a Lorentzian-like 2175 A bump profile, a well-determined FUV curvature term, and an underlying linear component. The parameters of the linear component are strongly correlated and therefore only five free parameters are required to fit all of the curves in our sample. Three parameters describe the 2175 A bump, one parameter describes the linear background, and one parameter describes the strength of the FUV curvature term. The shape of the FUV curvature is found to be identical, to within the observational errors, for all the curves in the sample - which spans virtually the entire range of extinction curve morphologies observed in the Milky Way.

Fitzpatrick, Edward L.; Massa, Derck

1988-01-01

175

Instructions for Glacier Recession Lesson Objective: Students will learn  

E-print Network

Instructions for Glacier Recession Lesson Objective: Students will learn: - about the connection between glaciers and climate, - why glacial studies are important, - how glacier recession affects humanity, and - how humans are affecting glaciers. Materials: Movie ­ Inconvenient Truth For Exercise

176

A linear analysis of the transition curve for the baroclinic annulus  

NASA Technical Reports Server (NTRS)

A primitive equation linear model is shown to be capable of quantitatively predicting the neutral curve for a baroclinic annulus. Flows unstable to small nonaxisymmetric perturbations are assumed to lie on the nonaxisymmetric side of a transition curve, while the stable flows are on the axisymmetric side. The stability in the presence of perturbations is tested with linearized hydrostatic primitive equations. Attention is given to the fastest growing eigenmodes, demonstrating that the linear and nonlinear wave have similar structures at a particular point in the nonaxisymmetric regime. All the waves are similar to the Eddy wave except at the extreme to the transition curve, where the waves maintain little structure with height. The eddy kinetic energy is baroclinic with a potential energy suppresed by the large static stability of the basic state. Eddy dissipation is noted to be significant near all boundaries.

Miller, T. L.; Gall, R. L.

1983-01-01

177

Fourier Analysis of Gamma-Ray Burst Light Curves: Searching for Direct Signature of Cosmological Time Dilation  

E-print Network

We study the power density spectrum (PDS) of light curves of the observed gamma-ray bursts (GRBs) to search for a direct signature for cosmological time dilation in the PDS statistics with the GRBs whose redshifts $z$'s are known. The anticorrelation of a timescale measure and a brightness measure is indirect evidence of its effect. On the other hand, we directly demonstrate that a time dilation effect can be seen in GRB light curves. We find that timescales tend to be shorter in bursts with small redshift, as expected from cosmological time-dilation effects, and we also find that there may be non-cosmological effects constituting to this correlation. We discuss its implication on interpretations of the PDS analysis results. We put forward another caution to this kind of analysis when we statistically exercise with GRBs whose $z$ is unknown.

Heon-Young Chang

2001-06-13

178

Generalized semi-analytical finite difference method for dispersion curves calculation and numerical dispersion analysis for Lamb waves.  

PubMed

The paper presents an efficient and accurate method for dispersion curve calculation and analysis of numerical models for guided waves. The method can be used for any arbitrarily selected anisotropic material. The proposed approach utilizes the wave equation and through-thickness-only discretization of anisotropic, layered plates to obtain the Lamb wave characteristics. Thus, layered structures, such as composites, can be analyzed in a straightforward manner. A general framework for the proposed analysis is given, along with application examples. Although these examples are based on the local interaction simulation approach for elastic waves propagation, the proposed methodology can be easily adopted for other methods (e.g., finite elements). The method can be also used to study the influence of discretization parameters on dispersion curves estimates. PMID:25190375

Packo, Pawel; Uhl, Tadeusz; Staszewski, Wieslaw J

2014-09-01

179

The Mathematical Analysis for Peristaltic Flow of Hyperbolic Tangent Fluid in a Curved Channel  

NASA Astrophysics Data System (ADS)

In the present paper, we have investigated the peristaltic flow of hyperbolic tangent fluid in a curved channel. The governing equations of hyperbolic tangent fluid model for curved channel are derived including the effects of curvature. The highly nonlinear partial differential equations are simplified by using the wave frame transformation, long wave length and low Reynolds number assumptions. The reduced nonlinear partial differential equation is solved analytically with the help of homotopy perturbation method (HPM). The physical features of pertinent parameters have been discussed by plotting the graphs of pressure rise and stream functions.

Nadeem, S.; E. N., Maraj

2013-06-01

180

The mathematical analysis for peristaltic flow of nano fluid in a curved channel with compliant walls  

NASA Astrophysics Data System (ADS)

In the present paper, we have investigated the peristaltic flow of nano fluid in a curved channel with compliant walls. The governing equations of nano fluid model for curved channel are derived including the effects of curvature. The highly nonlinear partial differential equations are simplified using the long wave length and low Reynolds number assumptions. The reduced nonlinear partial differential equation is solved analytically with the help of homotopy perturbation method. The physical features of pertinent parameters have been discussed by plotting the graphs of pressure rise, velocity, temperature, nano particle volume fraction and stream functions.

Nadeem, S.; Maraj, E. N.

2014-01-01

181

Radial velocity-acceleration curve analysis of the spectroscopic binary stars by the nonlinear regression  

E-print Network

We will introduce a new method to derive the orbital elements of the spectroscopic binary stars. Fitting the adopted radial velocity curves on the measured experimental data, the corresponding radial acceleration data are obtained. The orbital parameters are estimated by the nonlinear least squares of the radial velocity-acceleration curves. This method is implemented for the three double line spectroscopic binary systems RZ CAS, CC Cas and V1130 Tau. Numerical calculations show that the result are in good agreement with the those obtained by others using the method of Lehmann-Filh\\'{e}s.

K. Karami; H. Teimoorinia

2011-01-31

182

High-Resolution Melting Curve Analysis, a Rapid and Affordable Method for Mutation Analysis in Childhood Acute Myeloid Leukemia  

PubMed Central

Background: Molecular genetic alterations with prognostic significance have been described in childhood acute myeloid leukemia (AML). The aim of this study was to establish cost-effective techniques to detect mutations of FMS-like tyrosine kinase 3 (FLT3), nucleophosmin 1 (NPM1), and a partial tandem duplication within the mixed-lineage leukemia (MLL-PTD) genes in childhood AML. Procedure: Ninety-nine children with newly diagnosed AML were included in this study. We developed a fluorescent dye SYTO-82 based high-resolution melting (HRM) curve analysis to detect FLT3 internal tandem duplication (FLT3-ITD), FLT3 tyrosine kinase domain (FLT3-TKD), and NPM1 mutations. MLL-PTD was screened by real-time quantitative PCR. Results: The HRM methodology correlated well with gold standard Sanger sequencing with less cost. Among the 99 patients studied, the FLT3-ITD mutation was associated with significantly worse event-free survival (EFS). Patients with the NPM1 mutation had significantly better EFS and overall survival. However, HRM was not sensitive enough for minimal residual disease monitoring. Conclusion: High-resolution melting was a rapid and efficient method for screening of FLT3 and NPM1 gene mutations. It was both affordable and accurate, especially in resource underprivileged regions. Our results indicated that HRM could be a useful clinical tool for rapid and cost-effective screening of the FLT3 and NPM1 mutations in AML patients. PMID:25250304

Liu, Yin; Tang, Jingyan; Wakamatsu, Peter; Xue, Huiliang; Chen, Jing; Gaynon, Paul S.; Shen, Shuhong; Sun, Weili

2014-01-01

183

Analysis of a New Variational Model to Restore Point-Like and Curve-Like Singularities in Imaging  

SciTech Connect

The paper is concerned with the analysis of a new variational model to restore point-like and curve-like singularities in biological images. To this aim we investigate the variational properties of a suitable energy which governs these pathologies. Finally in order to realize numerical experiments we minimize, in the discrete setting, a regularized version of this functional by fast descent gradient scheme.

Aubert, Gilles, E-mail: gaubert@unice.fr [Universite de Nice Sophia Antipolis, Laboratoire J.A. Dieudonne (France)] [Universite de Nice Sophia Antipolis, Laboratoire J.A. Dieudonne (France); Blanc-Feraud, Laure, E-mail: Laure.Blanc-Feraud@inria.fr; Graziani, Daniele, E-mail: Daniele.Graziani@inria.fr [Inria, Morpheme CNRS/INRIA/UNSA Sophia Antipolis (France)] [Inria, Morpheme CNRS/INRIA/UNSA Sophia Antipolis (France)

2013-02-15

184

The data mining: An analysis of 20 eclipsing binary light-curves observed by the INTEGRAL/OMC  

E-print Network

Twenty eclipsing binaries were selected for an analysis from a huge database of observations made by the INTEGRAL/OMC camera. The photometric data were processed and analyzed, resulting in a first light-curve study of these neglected eclipsing binaries. Most of the selected systems are the detached ones. The system ET Vel was discovered to be an eccentric one. Due to missing spectroscopic study of these stars, further detailed analyses are still needed.

P. Zasche

2008-11-11

185

NEW REACTOR DESIGN AND ANALYSIS OF NON LINEAR VIBRATIONS OF DOUBLY CURVED SHALLOW SHELL UNDER A THERMAL GRADIENT  

SciTech Connect

The present study concerns with the effects of material orthotropy,curvature, shear ratio and circumferential modulus under the influence of a temperature distribution throughout the shell structure. Here analysis is restricted to the study of nonlinear vibration of a doubly curved shell structure considering the periodic response of a simple bending mode due to curtailment of pages. Solutions of the problems with suitable illustrations are also presented.

Chanda, S.

2004-10-06

186

Higher order finite-difference frequency domain analysis of 2-D photonic crystals with curved dielectric interfaces.  

PubMed

A high-order finite-difference frequency domain method is proposed for the analysis of the band diagrams of two-dimensional photonic crystals. This improved formulation is based on Taylor series expansion, local coordinate transformation, boundary conditions matching, and the generalized Douglas scheme. The nine-point second-order formulas are extended to fourth-order accuracy. This proposed scheme can deal with piecewise homogeneous structures with curved dielectric interfaces. PMID:19259167

Chiang, Yen-Chung

2009-03-01

187

Understanding High Recession Rates of Carbon Ablators Seen in Shear Tests in an Arc Jet  

NASA Technical Reports Server (NTRS)

High rates of recession in arc jet shear tests of Phenolic Impregnated Carbon Ablator (PICA) inspired a series of tests and analysis on FiberForm (a carbon preform used in the fabrication of PICA). Arc jet tests were performed on FiberForm in both air and pure nitrogen for stagnation and shear configurations. The nitrogen tests showed little or no recession, while the air tests of FiberForm showed recession rates similar to that of PICA (when adjusted for the difference in density). While mechanical erosion can not be ruled out, this is the first step in doing so. Analysis using a carbon oxidation boundary condition within DPLR was used to predict the recession rate of FiberForm. The analysis indicates that much of the anomalous recession behavior seen in shear tests may simply be an artifact of the non-flight like test configuration (copper upstream of the test article) a result of dissimilar enthalpy and oxygen concentration profiles on the copper. Shape change effects were also investigated and shown to be relatively small.

Driver, David M.; Olson, Michael W.; Barnhardt, Michael D.; MacLean, Matthew

2010-01-01

188

Analysis of a Kepler Light Curve of the Novalike Cataclysmic Variable KIC 8751494  

NASA Astrophysics Data System (ADS)

We analyzed a Kepler light curve of KIC 8751494, a recently recognized novalike cataclysmic variable in the Kepler field. We detected a stable periodicity of 0.114379(1) d, which we identified as being the binary's orbital period. The stronger photometric period at around 0.12245 d, which had been detected from a ground-based observation, was found to be variable, and we identified this period as the positive-superhump period. This superhump period showed short-term (10-20 d) strong variations in period most unexpectedly when the object entered a slightly faint state. The fractional superhump excess varied by as much large as ˜ 30%. The variation of the period very well traced the variation of the brightness of the system. The time-scale of this variation of superhump periods was too slow to be interpreted as a variation caused by a change of the disk radius due to thermal disk instability. We interpreted the cause of the period variation as a varying pressure effect on the period of positive superhumps. This finding suggests that the pressure effect, in at least novalike systems, plays a very important (up to ˜ 30% in the precession rate) role in producing the period of positive superhumps. We also described a possible detection of negative superhumps with a varying period of 0.1071-0.1081 d in the Q14 run of the Kepler data, and found that the variation of frequency of negative superhumps followed that of positive superhumps. The relation between the fractional superhump excesses of negative and positive superhumps can be understood if the angular frequency of positive superhumps is decreased by a pressure effect. We also found that the phase of the variation in the velocity of the emission lines reported in the earlier study is compatible with the SW Sex-type classification. Further, we introduced a new two-dimentional period analysis using least absolute shrinkage and selection operator (Lasso), and showed superior advantages of this method.

Kato, Taichi; Maehara, Hiroyuki

2013-08-01

189

Open-Mode Debonding Analysis of Curved Sandwich Panels Subjected to Heating and Cryogenic Cooling on Opposite Faces  

NASA Technical Reports Server (NTRS)

Increasing use of curved sandwich panels as aerospace structure components makes it vital to fully understand their thermostructural behavior and identify key factors affecting the open-mode debonding failure. Open-mode debonding analysis is performed on a family of curved honeycomb-core sandwich panels with different radii of curvature. The curved sandwich panels are either simply supported or clamped, and are subjected to uniform heating on the convex side and uniform cryogenic cooling on the concave side. The finite-element method was used to study the effects of panel curvature and boundary condition on the open-mode stress (radial tensile stress) and displacement fields in the curved sandwich panels. The critical stress point, where potential debonding failure could initiate, was found to be at the midspan (or outer span) of the inner bonding interface between the sandwich core and face sheet on the concave side, depending on the boundary condition and panel curvature. Open-mode stress increases with increasing panel curvature, reaching a maximum value at certain high curvature, and then decreases slightly as the panel curvature continues to increase and approach that of quarter circle. Changing the boundary condition from simply supported to clamped reduces the magnitudes of open-mode stresses and the associated sandwich core depth stretching.

Ko, William L.

1999-01-01

190

Cautionary notes on the descriptive analysis of performance curves in reptiles  

Microsoft Academic Search

Organismal performance curves are important functions for the study of reptilian ecology and evolution, but their interpretation can be affected strongly by the choice of analytical approach. We first use an example from the literature to demonstrate that excluding biologically meaningful data alters the description of performance and leads to non-sensical inferences. We then use fictional data to show that

Grégory Bulté; Gabriel Blouin-Demers

2006-01-01

191

Progress-curve analysis in enzyme kinetics. Numerical solution of integrated rate equations.  

PubMed Central

Progress curves of enzyme-catalysed reactions are described by equations of a type that precludes direct calculation of the extent of reaction at any time. Previously, such equations have been solved by the Newton-Raphson method, but this procedure may fail when based upon the usual formulae. An alternative formulation is proposed that is both quicker and more robust. PMID:3741409

Duggleby, R G

1986-01-01

192

A Study of Decline Curve Analysis in the Elm Coulee Field  

E-print Network

, and Niobrara. New decline curve methods have been developed to replace the standard Arps model for use in shale gas wells, but much less study has been done to verify the accuracy of these methods in shale oil wells. The examples that I investigated were Arps...

Harris, Seth C

2013-08-22

193

The Latent Curve ARMA (P, Q) Panel Model: Longitudinal Data Analysis in Educational Research and Evaluation  

ERIC Educational Resources Information Center

Autocorrelated residuals in longitudinal data are widely reported as common to longitudinal data. Yet few, if any, researchers modeling growth processes evaluate a priori whether their data have this feature. Sivo, Fan, and Witta (2005) found that not modeling autocorrelated residuals present in longitudinal data severely biases latent curve

Sivo, Stephen; Fan, Xitao

2008-01-01

194

Receiver Operating Characteristic Curve Analysis of Wechsler Memory Scale-Revised Scores in Epilepsy Surgery Candidates.  

ERIC Educational Resources Information Center

Wechsler Memory Scale-Revised (WMS-R) scores were analyzed for 82 epilepsy surgery candidates and used in combination with receiver operating characteristic curves to classify patients with left (LTL) and right (RTL) temporal lobe seizure onset. Results indicate that WMS-R scores used alone or in combination provide relatively poor discrimination…

Barr, William B.

1997-01-01

195

Growth curves of deviant behavior in early adolescence: A multilevel analysis  

Microsoft Academic Search

Multilevel growth curve models provide a means of analyzing individual differences in the growth of deviance, allow a number of theories to be integrated in a single model, and can help to unify research on deviant\\/delinquent\\/criminal careers at different stages of the life cycle. Building on the distinction between “population heterogeneity” and “state dependence” as alternative explanations of persistent individual

Robert A. Johnson; John P. Hoffmann; S. Susan Su; Dean R. Gerstein

1997-01-01

196

Parent Involvement and Science Achievement: A Cross-Classified Multilevel Latent Growth Curve Analysis  

ERIC Educational Resources Information Center

The authors examined science achievement growth at Grades 3, 5, and 8 and parent school involvement at the same time points using the Early Childhood Longitudinal Study-Kindergarten Class of 1998-1999. Data were analyzed using cross-classified multilevel latent growth curve modeling with time invariant and varying covariates. School-based…

Johnson, Ursula Y.; Hull, Darrell M.

2014-01-01

197

Analysis of progress curves. Rate law of pyruvate kinase type I from Escherichia coli.  

PubMed Central

Progress curves of the reaction catalysed by pyruvate kinase from Escherichia coli K12, designed to cover the four-dimensional concentration space of phosphoenolpyruvate, ADP, Mg2+ and ATP in the regulatory region, were recorded with the pH-stat method (pH 7.0 and 25 degrees C). Additional initial-rate measurement were performed to assess specific points. Two methods for the evaluation of progress curves were used: fitting the rate law to the rates obtained from the tangents of the progress curves and fitting the integrated rate law directly to the curves. Two models, both extensions of the concerted model given by Monod, Wyman & Changeux [(1965) J. Mol. Biol. 12, 88--118] with four protomers, could be fitted to the data within the experimental error. Model discrimination in favour of one of these models was possible by proper experimental design. In the selected model one conformational state of the enzyme forms the active complex. The active site of a second conformational state forms abortive complexes with Mg2+, causing strong inhibition at high Mg2+ concentrations. In the absence of ligands, most of the enzyme is in a third state that binds ATP at an allosteric site. PMID:7011316

Markus, M; Plesser, T; Boiteux, A; Hess, B; Malcovati, M

1980-01-01

198

A Light Curve Analysis of Classical Novae: Free-free Emission versus Photospheric Emission  

NASA Astrophysics Data System (ADS)

We analyzed light curves of seven relatively slower novae, PW Vul, V705 Cas, GQ Mus, RR Pic, V5558 Sgr, HR Del, and V723 Cas, based on an optically thick wind theory of nova outbursts. For fast novae, free-free emission dominates the spectrum in optical bands rather than photospheric emission, and nova optical light curves follow the universal decline law. Faster novae blow stronger winds with larger mass-loss rates. Because the brightness of free-free emission depends directly on the wind mass-loss rate, faster novae show brighter optical maxima. In slower novae, however, we must take into account photospheric emission because of their lower wind mass-loss rates. We calculated three model light curves of free-free emission, photospheric emission, and their sum for various white dwarf (WD) masses with various chemical compositions of their envelopes and fitted reasonably with observational data of optical, near-IR (NIR), and UV bands. From light curve fittings of the seven novae, we estimated their absolute magnitudes, distances, and WD masses. In PW Vul and V705 Cas, free-free emission still dominates the spectrum in the optical and NIR bands. In the very slow novae, RR Pic, V5558 Sgr, HR Del, and V723 Cas, photospheric emission dominates the spectrum rather than free-free emission, which makes a deviation from the universal decline law. We have confirmed that the absolute brightnesses of our model light curves are consistent with the distance moduli of four classical novae with known distances (GK Per, V603 Aql, RR Pic, and DQ Her). We also discussed the reason why the very slow novae are about ~1 mag brighter than the proposed maximum magnitude versus rate of decline relation.

Hachisu, Izumi; Kato, Mariko

2015-01-01

199

Cutting Symmetrical Recesses In Soft Ceramic Tiles  

NASA Technical Reports Server (NTRS)

Simple tool cuts hemispherical recesses in soft ceramic tiles. Designed to expose wires of thermocouples embedded in tiles without damaging leads. Creates neat, precise holes around wires. End mill includes axial hole to accommodate thermocouple wires embedded in material to be cut. Wires pass into hole without being bent or broken. Dimensions in inches. Used in place of such tools as dental picks, tweezers, spatulas, and putty knives.

Nesotas, Tony C.; Tyler, Brent

1989-01-01

200

Recovering From Recession - With Far Less Pain  

NSDL National Science Digital Library

Thirty-seventh monthly installment of our "What A Year!" website project, introducing life science breakthroughs to middle and high school students and their teachers. Gum recession is both aesthetically unpleasant and medically risky. At risk are the patient's teeth and oral health. But the traditional treatment has been painful and not completely satisfactory. Now there is a new treatment that works better and reduces pain and discomfort.

2010-05-04

201

Recessive mutations in CAKUT and VACTERL association.  

PubMed

Understanding the complex genetic makeup underlying congenital anomalies of the kidney and urinary tract (CAKUT) is of primary importance to improve diagnosis, stratify risk for later-onset complications, and develop therapeutic strategies. Saisawat et al. used homozygosity mapping coupled with next-generation sequencing to identify recessive mutations in TRAP1 in families with isolated CAKUT and with VACTERL association. This study points to a novel player in kidney development, possibly affecting apoptosis and endoplasmic reticulum stress signaling. PMID:24875543

Westland, Rik; Sanna-Cherchi, Simone

2014-06-01

202

The Great Recession, unemployment and suicide  

PubMed Central

Background How have suicide rates responded to the marked increase in unemployment spurred by the Great Recession? Our paper puts this issue into a wider perspective by assessing (1) whether the unemployment-suicide link is modified by the degree of unemployment protection, and (2) whether the effect on suicide of the present crisis differs from the effects of previous economic downturns. Methods We analysed the unemployment-suicide link using time-series data for 30 countries spanning the period 1960–2012. Separate fixed-effects models were estimated for each of five welfare state regimes with different levels of unemployment protection (Eastern, Southern, Anglo-Saxon, Bismarckian and Scandinavian). We included an interaction term to capture the possible excess effect of unemployment during the Great Recession. Results The largest unemployment increases occurred in the welfare state regimes with the least generous unemployment protection. The unemployment effect on male suicides was statistically significant in all welfare regimes, except the Scandinavian one. The effect on female suicides was significant only in the eastern European country group. There was a significant gradient in the effects, being stronger the less generous the unemployment protection. The interaction term capturing the possible excess effect of unemployment during the financial crisis was not significant. Conclusions Our findings suggest that the more generous the unemployment protection the weaker the detrimental impact on suicide of the increasing unemployment during the Great Recession. PMID:25339416

Norström, Thor; Grönqvist, Hans

2015-01-01

203

Barcoding Melting Curve Analysis for Rapid, Sensitive, and Discriminating Authentication of Saffron (Crocus sativus L.) from Its Adulterants.  

PubMed

Saffron (Crocus sativus L.) is one of the most important and expensive medicinal spice products in the world. Because of its high market value and premium price, saffron is often adulterated through the incorporation of other materials, such as Carthamus tinctorius L. and Calendula officinalis L. flowers, Hemerocallis L. petals, Daucus carota L. fleshy root, Curcuma longa L. rhizomes, Zea may L., and Nelumbo nucifera Gaertn. stigmas. To develop a straightforward, nonsequencing method for rapid, sensitive, and discriminating detection of these adulterants in traded saffron, we report here the application of a barcoding melting curve analysis method (Bar-MCA) that uses the universal chloroplast plant DNA barcoding region trnH-psbA to identify adulterants. When amplified at DNA concentrations and annealing temperatures optimized for the curve analysis, peaks were formed at specific locations for saffron (81.92°C) and the adulterants: D. carota (81.60°C), C. tinctorius (80.10°C), C. officinalis (79.92°C), Dendranthema morifolium (Ramat.) Tzvel. (79.62°C), N. nucifera (80.58°C), Hemerocallis fulva (L.) L. (84.78°C), and Z. mays (84.33°C). The constructed melting curves for saffron and its adulterants have significantly different peak locations or shapes. In conclusion, Bar-MCA could be a faster and more cost-effective method to authenticate saffron and detect its adulterants. PMID:25548775

Jiang, Chao; Cao, Liang; Yuan, Yuan; Chen, Min; Jin, Yan; Huang, Luqi

2014-01-01

204

Barcoding Melting Curve Analysis for Rapid, Sensitive, and Discriminating Authentication of Saffron (Crocus sativus L.) from Its Adulterants  

PubMed Central

Saffron (Crocus sativus L.) is one of the most important and expensive medicinal spice products in the world. Because of its high market value and premium price, saffron is often adulterated through the incorporation of other materials, such as Carthamus tinctorius L. and Calendula officinalis L. flowers, Hemerocallis L. petals, Daucus carota L. fleshy root, Curcuma longa L. rhizomes, Zea may L., and Nelumbo nucifera Gaertn. stigmas. To develop a straightforward, nonsequencing method for rapid, sensitive, and discriminating detection of these adulterants in traded saffron, we report here the application of a barcoding melting curve analysis method (Bar-MCA) that uses the universal chloroplast plant DNA barcoding region trnH-psbA to identify adulterants. When amplified at DNA concentrations and annealing temperatures optimized for the curve analysis, peaks were formed at specific locations for saffron (81.92°C) and the adulterants: D. carota (81.60°C), C. tinctorius (80.10°C), C. officinalis (79.92°C), Dendranthema morifolium (Ramat.) Tzvel. (79.62°C), N. nucifera (80.58°C), Hemerocallis fulva (L.) L. (84.78°C), and Z. mays (84.33°C). The constructed melting curves for saffron and its adulterants have significantly different peak locations or shapes. In conclusion, Bar-MCA could be a faster and more cost-effective method to authenticate saffron and detect its adulterants.

Cao, Liang; Yuan, Yuan; Chen, Min; Jin, Yan; Huang, Luqi

2014-01-01

205

A New Derivative Type-Curve for Pressure Buildup Analysis with Boundary Effects  

SciTech Connect

This study investigates pressure buildup behavior of wells with wellbore storage and skin in bounded circular reservoirs, when inner and outer boundary effects interact to fully or partially dominate the well pressure response. Using dimensionless pressure derivative as the dependent variable, we show that early time response is governed by C{sub D}e{sup 2S} and late time response by r{sub eD}{sup 2}/C{sub D}. Equations are provided to estimate the limits of the intermediate time period, which corresponds to infinite acting radial flow and a semi-log straight line on a pressure-time graph. We present a new buildup derivative type curve, incorporating inner boundary (early-time) and outer boundary (late-time) effects. Applications of this type curve in buildup test design and interpretation are discussed. 2 figs., 8 refs.

Mishra, S.; Ramey, H.J. Jr.

1987-01-20

206

Limit analysis of masonry vaults by means of curved shell finite elements and homogenization  

Microsoft Academic Search

The study of masonry vaults should take into account the essentials of the material “masonry” – i.e. heterogeneity, almost no resistance to tension combined with a good compressive strength and a high friction coefficient, as well as the overall importance of the geometry for achieving the equilibrium.In this paper, a new six-noded triangular curved element, specifically developed for the kinematic

Enrico Milani; Gabriele Milani; Antonio Tralli

2008-01-01

207

New light curve analysis and period changes of the overcontact binary XY Leonis  

NASA Astrophysics Data System (ADS)

Light curves and photometric solutions of the contact binary XY Leo are presented. The UBVR light curves appear to be almost symmetric. The B and V light curves were analysed with the Wilson-Devinney code and the orbital parameters of the system were obtained and compared with those obtained in previous studies. All the times of minimum light were collected and combined with the new ones obtained in this study. The orbital period of the system oscillates with a period of 19.6 years and a semi-amplitude of 0.023 day. This regular change was analysed under the assumption of the third body hypothesis. The time delay and advance due to the orbit of the eclipsing pair around the third component were computed and subtracted from the original residuals obtained with the linear light elements. The remaining residuals also show a parabolic change. Therefore, we assumed that the orbital period of the system changes with time due to at least two different causes. The parabolic change of the period may be attributed to either mass transfer from less massive component to the more massive one, or an additional component bounded to the double binary system with a longer period.

Yakut, K.; ?bano?lu, C.; Kalomeni, B.; De?irmenci, Ö. L.

2003-04-01

208

CONFIRMATION OF HOT JUPITER KEPLER-41b VIA PHASE CURVE ANALYSIS  

SciTech Connect

We present high precision photometry of Kepler-41, a giant planet in a 1.86 day orbit around a G6V star that was recently confirmed through radial velocity measurements. We have developed a new method to confirm giant planets solely from the photometric light curve, and we apply this method herein to Kepler-41 to establish the validity of this technique. We generate a full phase photometric model by including the primary and secondary transits, ellipsoidal variations, Doppler beaming, and reflected/emitted light from the planet. Third light contamination scenarios that can mimic a planetary transit signal are simulated by injecting a full range of dilution values into the model, and we re-fit each diluted light curve model to the light curve. The resulting constraints on the maximum occultation depth and stellar density combined with stellar evolution models rules out stellar blends and provides a measurement of the planet's mass, size, and temperature. We expect about two dozen Kepler giant planets can be confirmed via this method.

Quintana, Elisa V.; Rowe, Jason F.; Caldwell, Douglas A.; Christiansen, Jessie L.; Jenkins, Jon M.; Morris, Robert L.; Smith, Jeffrey C.; Thompson, Susan E. [SETI Institute, 189 Bernardo Ave, Suite 100, Mountain View, CA 94043 (United States); Barclay, Thomas [Bay Area Environmental Research Institute/NASA Ames Research Center, Moffett Field, CA 94035 (United States); Howell, Steve B.; Borucki, William J.; Sanderfer, Dwight T.; Still, Martin [NASA Ames Research Center, Moffett Field, CA 94035 (United States); Ciardi, David R. [NASA Exoplanet Science Institute/Caltech, 770 South Wilson Ave., MC 100-2, Pasadena, CA 91125 (United States); Demory, Brice-Olivier [Department of Earth, Atmospheric and Planetary Sciences, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139 (United States); Klaus, Todd C. [Orbital Sciences Corporation/NASA Ames Research Center, Moffett Field, CA 94035 (United States); Fulton, Benjamin J.; Shporer, Avi, E-mail: elisa.quintana@nasa.gov [Las Cumbres Observatory Global Telescope Network, 6740 Cortona Drive, Suite 102, Santa Barbara, CA 93117 (United States)

2013-04-20

209

Statistically generated weighted curve fit of residual functions for modal analysis of structures  

NASA Technical Reports Server (NTRS)

A statistically generated weighting function for a second-order polynomial curve fit of residual functions has been developed. The residual flexibility test method, from which a residual function is generated, is a procedure for modal testing large structures in an external constraint-free environment to measure the effects of higher order modes and interface stiffness. This test method is applicable to structures with distinct degree-of-freedom interfaces to other system components. A theoretical residual function in the displacement/force domain has the characteristics of a relatively flat line in the lower frequencies and a slight upward curvature in the higher frequency range. In the test residual function, the above-mentioned characteristics can be seen in the data, but due to the present limitations in the modal parameter evaluation (natural frequencies and mode shapes) of test data, the residual function has regions of ragged data. A second order polynomial curve fit is required to obtain the residual flexibility term. A weighting function of the data is generated by examining the variances between neighboring data points. From a weighted second-order polynomial curve fit, an accurate residual flexibility value can be obtained. The residual flexibility value and free-free modes from testing are used to improve a mathematical model of the structure. The residual flexibility modal test method is applied to a straight beam with a trunnion appendage and a space shuttle payload pallet simulator.

Bookout, P. S.

1995-01-01

210

Curved Mirrors  

NSDL National Science Digital Library

This inquiry activity will be used before discussing curved mirrors in class. Students will discover how curved mirrors act and how the size and the orientation of the image are related to the distance from the mirror. Ray diagrams for curved mirrors are

Horton, Michael

2009-05-30

211

Mutations of the tyrosinase gene produce autosomal recessive ocular albinism  

SciTech Connect

Albinism has historically been divided into ocular (OA) and oculocutaneous (OCA) types based on the presence or absence of clinically apparent skin and hair involvement in an individual with the ocular features of albinism. The major genes for OCA include the tyrosinase gene in OCA1 and the P gene in OCA2. X-linked and autosomal recessive OA have been described and the responsible genes have not been identified. We now present six Caucasian individuals who have the phenotype of autosomal recessive OA but who have OCA1 as shown by the presence of mutations of the tyrosinase. They had white or very light hair and white skin at birth, and cutaneous pigment developed in the first decade of life. At ages ranging from 1.5-23 years, hair color was dark blond to light brown. The skin had generalized pigment and well developed tan was present on the exposed arm and face skin of four. Iris pigment was present and iris translucency varied. Molecular analysis of the tyrosinase gene, using PCR amplification and direct di-deoxy sequencing showed the following mutations: E398Z/E398Q, P406S/g346a, R402E/T373K, ?/D383N, and H211N/T373K. The homozygous individual was not from a known consanguineous mating. T373K is the most common tyrosinase gene mutation in our laboratory. Three of these mutations are associated with a total loss of tyrosinase activity (g346a splice-site, T373K, and D383N), while four are associated with residual enzyme activity (H211N, R402E, E398Q, and P406S). These studies show that mutations of the tyrosinase gene can produce the phenotype of autosomal recessive OA in an individual who has normal amounts of cutaneous pigment and the ability to tan after birth. This extends the phenotypic range of OCA1 to normal cutaneous pigment after early childhood, and suggest that mutations of the tyrosinase gene account for a significant number of individuals with autosomal recessive OA.

King, R.A.; Summers, C.G.; Oetting, W.S. [Univ. of Minnesota, Minneapolis, MN (United States)] [and others

1994-09-01

212

Tests of a Simulated Annealing Program for Eclipsing Binary Light Curve Analysis  

NASA Astrophysics Data System (ADS)

Numerical experiments have been carried out with a Simulated Annealing program incorporated into the light curve modeling package WD2007, the latest version of this package initially called WD95, developed and maintained by JK. Simulated annealing (SA) is one a number of metaheuristic methods that have been used in various scientific, economic, and business applications, to seek the absolute minimum of functions in multi-dimensional parameter space. SA draws on an analogue from metallurgy that makes use of an optimum cooling process. The search is conducted, as with other optimization procedures, by following a course toward the deepest minimum, but permits jumps to less optimum solutions by a quasi-random procedure using the "Metropolis criterion," involving a probability that decreases with the 'temperature," a quantity that describes the annealing state over time. It is this capability of escaping from a local minimum that allows wider sampling of parameter solution space. We used as test data a simulated light-curve, based loosely on light curves of the over-contact system V781 Tau. In this work we tested the goodness of fit and the efficiency of the SA algorithm we employed, against our damped least squares and simplex programs, also located in WD2007. Although we find that SA as coded here, is far less efficient than DLS (a purely-down-hill gradient program) and simplex, it appears sufficiently robust to avoid getting stuck in a local minimum, for the most part, if the initial "temperature" is high enough. It is, however, hardly fool-proof. Nevertheless, for initial model exploration, and as a check on solutions found by the other methods, simulated annealing appears to offer another useful test in the search for true global minima. This work was supported in part by grants to EFM from the Canadian Natural Sciences and Engineering Research Council.

Milone, Eugene F.; Kallrath, J.

2007-05-01

213

Progress curve analysis for enzyme and microbial kinetic reactions using explicit solutions based on the Lambert W function.  

PubMed

We present a simple method for estimating kinetic parameters from progress curve analysis of biologically catalyzed reactions that reduce to forms analogous to the Michaelis-Menten equation. Specifically, the Lambert W function is used to obtain explicit, closed-form solutions to differential rate expressions that describe the dynamics of substrate depletion. The explicit nature of the new solutions greatly simplifies nonlinear estimation of the kinetic parameters since numerical techniques such as the Runge-Kutta and Newton-Raphson methods used to solve the differential and integral forms of the kinetic equations, respectively, are replaced with a simple algebraic expression. The applicability of this approach for estimating Vmax and Km in the Michaelis-Menten equation was verified using a combination of simulated and experimental progress curve data. For simulated data, final estimates of Vmax and Km were close to the actual values of 1 microM/h and 1 microM, respectively, while the standard errors for these parameter estimates were proportional to the error level in the simulated data sets. The method was also applied to hydrogen depletion experiments by mixed cultures of bacteria in activated sludge resulting in Vmax and Km estimates of 6.531 microM/h and 2.136 microM, respectively. The algebraic nature of this solution, coupled with its relatively high accuracy, makes it an attractive candidate for kinetic parameter estimation from progress curve data. PMID:15488275

Goudar, Chetan T; Harris, Steve K; McInerney, Michael J; Suflita, Joseph M

2004-12-01

214

Self-modeling curve resolution techniques applied to comparative analysis of volatile components of Iranian saffron from different regions.  

PubMed

Volatile components of saffron from different regions of Iran were extracted by ultrasonic-assisted solvent extraction (USE) and were analyzed by gas chromatography-mass spectrometry (GC-MS). Self-modeling curve resolution (SMCR) was proposed for resolving the co-eluted GC-MS peak clusters into pure chromatograms and mass spectra. Multivariate curve resolution-objective function minimization (MCR-FMIN) and multivariate curve resolution-alternating least square (MCR-ALS) were successfully used for this purpose. The accuracy of the qualitative and quantitative results was improved considerably using SMCR techniques. Comparison of the results of saffron from different regions of Iran showed that their volatile components are different from chemical components and relative percentages points of view. Safranal is the main component of all samples. In addition, 4-hydroxy-2,6,6-trimethyl-1-cyclohexene-1-carboxaldehyde (HTCC), 2(5H)-furanone, 2,4,4-trimethyl-3-carboxaldehyde-5-hydroxy-2,5-cyclohexadien-1-one and 2(3H)-furanone, dihydro-4-hydroxy were common in all samples with high percentages. The results proved that combining of SMCR techniques with USE-GC-MS produces a powerful tool for the analysis of the complex samples. PMID:20171313

Jalali-Heravi, Mehdi; Parastar, Hadi; Ebrahimi-Najafabadi, Heshmatollah

2010-03-10

215

The analysis of dose-response curves--a practical approach.  

PubMed Central

The rationale for the objective assessment of dose-response curves (DRCs) is presented. Using data derived from isoprenaline/heart rate responses studies, two new statistical methods of objectively defining the terminal linear segment of an incomplete DRC are presented. Using data derived from phenylephrine/diastolic blood pressure response studies, the parallel shift quadratic model of Sumner et al. (1982) has been extended to include a measure of the suitability of the quadratic model for each individual data set using the Akaike information criterion. A parallel shift Emax model is proposed for complete DRCs. PMID:3828197

Jackson, S H; Jamieson, M J; Johnston, A; Shepherd, A M

1987-01-01

216

Buckling Analysis of Anisotropic Curved Panels and Shells with Variable Curvature  

NASA Technical Reports Server (NTRS)

A buckling formulation for anisotropic curved panels with variable curvature is presented in this paper. The variable curvature panel is assumed to consists of two or more panels of constant but different curvatures. Bezier functions are used as Ritz functions Displacement (C(sup 0)), and slope (C(sup 1)) continuities between segments are imposed by manipulation of the Bezier control points. A first-order shear-deformation theory is used in the buckling formulation. Results obtained from the present formulation are compared with those from finite element simulations and are found to be in good agreement.

Jaunky, Navin; Knight, Norman F., Jr.; Ambur, Damodar R.

1998-01-01

217

Zirconium determination by cooling curve analysis during the pyroprocessing of used nuclear fuel  

NASA Astrophysics Data System (ADS)

An alternative method to sampling and chemical analyses has been developed to monitor the concentration of zirconium in real-time during the casting of uranium products from the pyroprocessing of used nuclear fuel. The method utilizes the solidification characteristics of the uranium products to determine zirconium levels based on standard cooling curve analyses and established binary phase diagram data. Numerous uranium products have been analyzed for their zirconium content and compared against measured zirconium data. From this data, the following equation was derived for the zirconium content of uranium products:

Westphal, B. R.; Price, J. C.; Bateman, K. J.; Marsden, K. C.

2015-02-01

218

Detection and differentiation of avian reoviruses using SYBR-Green I-based two-step real-time reverse transcription PCR with melting curve analysis.  

PubMed

A two-step SYBR-Green I-based real-time PCR with melting curve analysis was developed to detect and differentiate the avian reovirus (ARV) sigmaC gene in field and vaccine ARVs. Three primer sets were used to amplify the sigmaC gene from its 5', center, and 3' regions and analyze the melting point temperatures of nine ARVs. By combining the melting curves of the three ARV sigmaC gene regions, melting curve analysis could accurately distinguish the ARVs of different subtypes, and the results were consistent with phylogenetic analysis. The ARV sigmaC gene polymorphisms from different strains were also used to explain the differences in melting point temperatures. Compared with traditional subtyping methods, the current melting curve analysis provided an accurate test for separating ARVs, thereby making it a useful method for the improved selection of ARV vaccines. PMID:22856196

Guo, Kejun; Dormitorio, Teresa; Ou, Shan-Cia; Giambrone, Joseph

2012-06-01

219

Tails of Lorenz curves  

Microsoft Academic Search

The Lorenz dominance criterion is the centre piece of inequality analysis. Yet, the appeal of this criterion, which requires considering Lorenz curves in their entirety, is undermined by the practical problem that many sample Lorenz curves intersect in the tails. The commonly used inferential methods, based on central limit theorem arguments, do not apply to the tails since these contain

Christian Schluter; Mark Trede

2002-01-01

220

Abnormal melt curve profile during prothrombin 20210G --> A analysis due to the 20209C --> T variant.  

PubMed

The common factor II 20210G --> A mutation, located in the 3'-untranslated region, is an important risk factor for the development of thromboembolic disorders, especially in Caucasians. A number of methods are employed for clinical laboratory diagnosis of this mutation, some of which are capable of detecting adjacent 3'-end sequence variations. We present results from an African deep vein thrombosis patient tested for the 20210G --> A mutation by real-time polymerase chain reaction and melt-curve analysis using hybridization probes that incidentally detected an adjacent 3'-untranslated region variant. The patient sample was tested using the Factor II (Prothromobin) G20210A Kit (Roche Diagnostics, Indianapolis, Indiana, USA), in conjunction with the Roche LightCycler. A polymerase chain reaction fragment from the 3'-end of the F2 gene was subsequently sequenced for identification of the variant. Melt-curve analysis revealed a normal 20210*G peak and an unknown aberrant allelic peak. Following sequence analysis, the patient was determined to be heterozygous for 20209C --> T. The presence of the 20209C --> T variant in the current patient and in eight other reported individuals of African descent, most with thrombosis-associated complaints, suggests that this rare variant poses a potential increased risk for thromboembolic disease in this ethnic group. PMID:16988559

Dunn, S Terence; Allen, Richard A; Bates, Francesca; McNamara, Victoria; Comp, Philip

2006-10-01

221

Simultaneous detection of Fusarium culmorum and F. graminearum in plant material by duplex PCR with melting curve analysis  

PubMed Central

Background Fusarium head blight (FHB) is a disease of cereal crops, which has a severe impact on wheat and barley production worldwide. Apart from reducing the yield and impairing grain quality, FHB leads to contamination of grain with toxic secondary metabolites (mycotoxins), which pose a health risk to humans and livestock. The Fusarium species primarily involved in FHB are F. graminearum and F. culmorum. A key prerequisite for a reduction in the incidence of FHB is an understanding of its epidemiology. Results We describe a duplex-PCR-based method for the simultaneous detection of F. culmorum and F. graminearum in plant material. Species-specific PCR products are identified by melting curve analysis performed in a real-time thermocycler in the presence of the fluorescent dye SYBR Green I. In contrast to multiplex real-time PCR assays, the method does not use doubly labeled hybridization probes. Conclusion PCR with product differentiation by melting curve analysis offers a cost-effective means of qualitative analysis for the presence of F. culmorum and F. graminearum in plant material. This method is particularly suitable for epidemiological studies involving a large number of samples. PMID:16430784

Brandfass, Christoph; Karlovsky, Petr

2006-01-01

222

The Application of the Principal Curve Analysis Technique to Smooth Beam Lines  

SciTech Connect

The smoothness of a beam line refers to the quality of the relative positioning of a number of adjacent beam guiding components. The fact that smoothness is of highest priority when positioning magnets can be seen in the local tolerances imposed by the beam optics. In the past, smoothing has been done by separating horizontal and vertical misalignments and then applying some sort of analytical or manual ''feathering'' technique. The Stanford Linear Collider (SLC) did not easily lend itself to this sort of smoothing because of the highly coupled nature of its pitched and rolled beam line. This paper will discuss an attempt to develop a repeatable method which is independent of the inconsistencies of human judgment and can simultaneously smooth in two or more dimensions. Four major goals were defined for the smoothing algorithm used on the SLC alignment. The first, was to simultaneously model errors for both horizontal and vertical directions. Secondly, a smooth curve whose shape was suggested by the data and not by a predetermined model was implied by the fact that unknown systematic errors were being eliminated. Thirdly, this curve must be a reproducibly fit, independent of the inconsistent nature of human judgment. Fourth, the result of the procedure was to minimize the number and size of magnet movements to reach the final alignment criteria.

Friedsam, H.; Oren, W.; /SLAC

2005-08-12

223

Is the Elimination of Recess in School a Violation of a Child's Basic Human Rights?  

ERIC Educational Resources Information Center

The elimination of recess in schools across the country is becoming a normal occurrence in many communities, large and small. In each study presented in this content analysis, we find that free time and unstructured play is indeed essential to a child's healthy cognitive development. Article 31 of the United Nations Convention on the Rights of…

Dubroc, Alicia M.

2007-01-01

224

A Synthetic Spectrum and Light Curve Analysis of the Cataclysmic Variable IX Velorum  

E-print Network

Spectrum synthesis analysis of FUSE and STIS spectra of the cataclysmic variable IX Velorum successfully produces a system model. Light synthesis analysis of K band photometry shows that the accretion disk rim is vertically extended beyond the gravitational equilibrium value.

Albert P. Linnell; Patrick Godon; Ivan Hubeny; Edward M. Sion; Paula Szkody

2007-03-15

225

A Synthetic Spectrum and Light Curve Analysis of the Cataclysmic Variable IX Velorum  

E-print Network

Spectrum synthesis analysis of FUSE and STIS spectra of the cataclysmic variable IX Velorum successfully produces a system model. Light synthesis analysis of K band photometry shows that the accretion disk rim is vertically extended beyond the gravitational equilibrium value.

Linnell, A P; Hubeny, I; Sion, E M; Szkody, P; Linnell, Albert P.; Godon, Patrick; Hubeny, Ivan; Sion, Edward M.; Szkody, Paula

2006-01-01

226

A TRANSIT TIMING ANALYSIS OF NINE RISE LIGHT CURVES OF THE EXOPLANET SYSTEM TrES-3  

SciTech Connect

We present nine newly observed transits of TrES-3, taken as part of a transit timing program using the RISE instrument on the Liverpool Telescope. A Markov-Chain Monte Carlo analysis was used to determine the planet-star radius ratio and inclination of the system, which were found to be R{sub p} /R {sub *} = 0.1664{sup +0.0011} {sub -0.0018} and i = 81.73{sup +0.13} {sub -0.04}, respectively, consistent with previous results. The central transit times and uncertainties were also calculated, using a residual-permutation algorithm as an independent check on the errors. A re-analysis of eight previously published TrES-3 light curves was conducted to determine the transit times and uncertainties using consistent techniques. Whilst the transit times were not found to be in agreement with a linear ephemeris, giving {chi}{sup 2} = 35.07 for 15 degrees of freedom, we interpret this to be the result of systematics in the light curves rather than a real transit timing variation. This is because the light curves that show the largest deviation from a constant period either have relatively little out-of-transit coverage or have clear systematics. A new ephemeris was calculated using the transit times and was found to be T{sub c} (0) = 2454632.62610 {+-} 0.00006 HJD and P = 1.3061864 {+-} 0.0000005 days. The transit times were then used to place upper mass limits as a function of the period ratio of a potential perturbing planet, showing that our data are sufficiently sensitive to have probed sub-Earth mass planets in both interior and exterior 2:1 resonances, assuming that the additional planet is in an initially circular orbit.

Gibson, N. P.; Pollacco, D.; Simpson, E. K.; Barros, S.; Joshi, Y. C.; Todd, I.; Keenan, F. P. [Astrophysics Research Centre, School of Mathematics and Physics, Queen's University, University Road, Belfast, BT7 1NN (United Kingdom); Skillen, I.; Benn, C. [Isaac Newton Group of Telescopes, Apartado de Correos 321, E-38700 Santa Cruz de la Palma, Tenerife (Spain); Christian, D. [Physics and Astronomy Department, California State University Northridge, Northridge, California 91330-8268 (United States); Hrudkova, M. [Astronomical Institute, Charles University Prague, V Holesovickach 2, CZ-180 00 Praha (Czech Republic); Steele, I. A. [Astrophysics Research Institute, Liverpool John Moores University, CH61 4UA (United Kingdom)], E-mail: ngibson07@qub.ac.uk

2009-08-01

227

Feasibility analysis on integration of luminous environment measuring and design based on exposure curve calibration  

NASA Astrophysics Data System (ADS)

Besides illumination calculating during architecture and luminous environment design, to provide more varieties of photometric data, the paper presents combining relation between luminous environment design and SM light environment measuring system, which contains a set of experiment devices including light information collecting and processing modules, and can offer us various types of photometric data. During the research process, we introduced a simulation method for calibration, which mainly includes rebuilding experiment scenes in 3ds Max Design, calibrating this computer aid design software in simulated environment under conditions of various typical light sources, and fitting the exposure curves of rendered images. As analytical research went on, the operation sequence and points for attention during the simulated calibration were concluded, connections between Mental Ray renderer and SM light environment measuring system were established as well. From the paper, valuable reference conception for coordination between luminous environment design and SM light environment measuring system was pointed out.

Zou, Yuan; Shen, Tianxing

2013-03-01

228

Light Curve Analysis for W UMa-Type Eclipsing Binary Star Systems  

NASA Astrophysics Data System (ADS)

We report results from summer 2006 in an ongoing study of eclipsing binary stars. Our investigations have focused on the measurement and interpretation of light curves for W UMa-type systems 44i Boötis and VW Cephei. These contact binaries have component stars of spectral type G, and revolve with periods of 6.43 and 6.67 hours. Dome automation and scripting capabilities introduced this summer have significantly reduced experimental uncertainties in our data. In support of previous findings we continue to observe an increase in the orbital period of 44i Boo at a rate of 10.4 µs/epoch or 14.2 ms/yr. Residuals computed after incorporating the increasing period suggest an underlying sinusoidal oscillation with a 61.5 year period and amplitude of 648 seconds. AAPT Member Thomas Olsen is sponsoring the lead presenter, SPS Member Scott Henderson, and the co-presenter, SPS Member Nick Peach.

Henderson, Scott; Peach, N.; Olsen, T.

2006-12-01

229

p-Version curved shell element for geometrically nonlinear analysis of laminated composite plates and shells  

SciTech Connect

This paper presents a p-version geometrically nonlinear formulation for laminated composites based on the total Lagrangian approach for a nine node three dimensional curved shell element. The element displacement approximation can be of arbitrary and different polynomial orders in the plane of the element and in the transverse direction. The element approximation functions are derived from the Lagrange family of interpolation functions and ensure C{degree} continuity. The lamina properties are incorporated by numerically integrating the element stiffness matrix for each lamina. Complete three dimensional stresses and strains are considered. Incremental equations of equilibrium are derived and solved using the standard Newton-Raphson method. Numerical examples are presented to show the accuracy, efficiency and advantages of the present formulation.

Sorem, R.M.; Surana, K.S. [Univ. of Kansas, Lawrence, KS (United States). Dept. of Mechanical Engineering

1997-07-01

230

Quantitative Vibrational Imaging by Hyperspectral Stimulated Raman Scattering Microscopy and Multivariate Curve Resolution Analysis  

PubMed Central

Spectroscopic imaging has been an increasingly critical approach for unveiling specific molecules in biological environments. Towards this goal, we demonstrate hyperspectral stimulated Raman loss (SRL) imaging by intra-pulse spectral scanning through a femtosecond pulse shaper. The hyperspectral stack of SRL images is further analyzed by a multivariate curve resolution (MCR) method to reconstruct quantitative concentration images for each individual component and retrieve the corresponding vibrational Raman spectra. Using these methods, we demonstrate quantitative mapping of dimethyl sulfoxide concentration in aqueous solutions and in fat tissue. Moreover, MCR is performed on SRL images of breast cancer cells to generate maps of principal chemical components along with their respective vibrational spectra. These results show the great capability and potential of hyperspectral SRL microscopy for quantitative imaging of complicated biomolecule mixtures through resolving overlapped Raman bands. PMID:23198914

Zhang, Delong; Wang, Ping; Slipchenko, Mikhail N.; Ben-Amotz, Dor; Weiner, Andrew M.; Cheng, Ji-Xin

2013-01-01

231

Determination of ethanol and specific gravity in gasoline by distillation curves and multivariate analysis.  

PubMed

The partial least-squares regression method (PLS) was employed to predict the amount of ethanol and specific gravity in automotive gasoline using distillation curves (ASTM-D86). Additionally, a comparison was made between regression coefficients of all the algorithms, after selecting the number of latent variables. The low values obtained for RMSEC and RMSEP, associated with high accuracy when compared to the standard methodologies (NBR-13992, ASTM-D4052 and D1298) showed that PLS was efficient to determine the ethanol content and specific gravity in gasoline, since the model contains samples of different gasoline compositions, thus reflecting the variety of fuel in the Brazilian market. In addition, the proposed method is low cost, time reducing and easy to implement, as it utilizes the results of a routine assay carried out to evaluate the quality of automotive fuel. PMID:19362211

Aleme, Helga G; Costa, Letícia M; Barbeira, Paulo J S

2009-06-15

232

Quantifying differences in the epidemic curves from three influenza surveillance systems: a nonlinear regression analysis.  

PubMed

SUMMARY Influenza surveillance enables systematic collection of data on spatially and demographically heterogeneous epidemics. Different data collection mechanisms record different aspects of the underlying epidemic with varying bias and noise. We aimed to characterize key differences in weekly incidence data from three influenza surveillance systems in Melbourne, Australia, from 2009 to 2012: laboratory-confirmed influenza notified to the Victorian Department of Health, influenza-like illness (ILI) reported through the Victorian General Practice Sentinel Surveillance scheme, and ILI cases presenting to the Melbourne Medical Deputising Service. Using nonlinear regression, we found that after adjusting for the effects of geographical region and age group, characteristics of the epidemic curve (including season length, timing of peak incidence and constant baseline activity) varied across the systems. We conclude that unmeasured factors endogenous to each surveillance system cause differences in the disease patterns recorded. Future research, particularly data synthesis studies, could benefit from accounting for these differences. PMID:24759447

Thomas, E G; McCAW, J M; Kelly, H A; Grant, K A; McVERNON, J

2015-01-01

233

VSX2 mutations in autosomal recessive microphthalmia  

PubMed Central

Purpose To further explore the spectrum of mutations in the Visual System Homeobox 2 (VSX2/CHX10) gene previously found to be associated with autosomal recessive microphthalmia. Methods We screened 95 probands with syndromic or isolated developmental ocular conditions (including 55 with anophthalmia/microphthalmia) for mutations in VSX2. Results Homozygous mutations in VSX2 were identified in two out of five consanguineous families with isolated microphthalmia. A novel missense mutation, c.668G>C (p.G223A), was identified in a large Pakistani family with multiple sibships affected with bilateral microphthalmia. This p.G223A mutation affects the conserved CVC motif that was shown to be important for DNA binding and repression activities of VSX2. The second mutation, c.249delG (p.Leu84SerfsX57), was identified in an Iranian family with microphthalmia; this mutation has been previously reported and is predicted to generate a severely truncated mutant protein completely lacking the VSX2 homeodomain, CVC domain and COOH-terminal regions. Conclusions Mutations in VSX2 represent an important cause of autosomal recessive microphthalmia in consanguineous pedigrees. Identification of a second missense mutation in the CVC motif emphasizes the importance of this region for normal VSX2 function. PMID:21976963

Reis, Linda M.; Khan, Ayesha; Kariminejad, Ariana; Ebadi, Farhad; Tyler, Rebecca C.

2011-01-01

234

Evaluation of pollutant loads from stormwater BMPs to receiving water using load frequency curves with uncertainty analysis.  

PubMed

This study examined pollutant loads released to receiving water from a typical urban watershed in the Los Angeles (LA) Basin of California by applying a best management practice (BMP) performance model that includes uncertainty. This BMP performance model uses the k-C model and incorporates uncertainty analysis and the first-order second-moment (FOSM) method to assess the effectiveness of BMPs for removing stormwater pollutants. Uncertainties were considered for the influent event mean concentration (EMC) and the aerial removal rate constant of the k-C model. The storage treatment overflow and runoff model (STORM) was used to simulate the flow volume from watershed, the bypass flow volume and the flow volume that passes through the BMP. Detention basins and total suspended solids (TSS) were chosen as representatives of stormwater BMP and pollutant, respectively. This paper applies load frequency curves (LFCs), which replace the exceedance percentage with an exceedance frequency as an alternative to load duration curves (LDCs), to evaluate the effectiveness of BMPs. An evaluation method based on uncertainty analysis is suggested because it applies a water quality standard exceedance based on frequency and magnitude. As a result, the incorporation of uncertainty in the estimates of pollutant loads can assist stormwater managers in determining the degree of total daily maximum load (TMDL) compliance that could be expected from a given BMP in a watershed. PMID:22578429

Park, Daeryong; Roesner, Larry A

2012-12-15

235

Scaling and disorder analysis of local I-V curves from ferroelectric thin films of lead zirconate titanate.  

PubMed

Differential analysis of current-voltage characteristics, obtained on the surface of epitaxial films of ferroelectric lead zirconate titanate (Pb(Zr(0.2)Ti(0.8))O(3)) using scanning probe microscopy, was combined with spatially resolved mapping of variations in local conductance to differentiate between candidate mechanisms of local electronic transport and the origin of disorder. Within the assumed approximations, electron transport was inferred to be determined by two mechanisms depending on the magnitude of applied bias, with the low-bias range dominated by the trap-assisted Fowler-Nordheim tunneling through the interface and the high-bias range limited by the hopping conduction through the bulk. Phenomenological analysis of the I-V curves has further revealed that the transition between the low- and high-bias regimes is manifested both in the strength of variations within the I-V curves sampled across the surface, as well as the spatial distribution of conductance. Spatial variations were concluded to originate primarily from the heterogeneity of the interfacial electronic barrier height with an additional small contribution from random changes in the tip-contact geometry. PMID:21572199

Maksymovych, Peter; Pan, Minghu; Yu, Pu; Ramesh, Ramamoorthy; Baddorf, Arthur P; Kalinin, Sergei V

2011-06-24

236

Development of Curved-Plate Elements for the Exact Buckling Analysis of Composite Plate Assemblies Including Transverse Shear Effects  

NASA Technical Reports Server (NTRS)

The analytical formulation of curved-plate non-linear equilibrium equations that include transverse-shear-deformation effects is presented. A unified set of non-linear strains that contains terms from both physical and tensorial strain measures is used. Using several simplifying assumptions, linearized, stability equations are derived that describe the response of the plate just after bifurcation buckling occurs. These equations are then modified to allow the plate reference surface to be located a distance z(c), from the centroid surface which is convenient for modeling stiffened-plate assemblies. The implementation of the new theory into the VICONOPT buckling and vibration analysis and optimum design program code is described. Either classical plate theory (CPT) or first-order shear-deformation plate theory (SDPT) may be selected in VICONOPT. Comparisons of numerical results for several example problems with different loading states are made. Results from the new curved-plate analysis compare well with closed-form solution results and with results from known example problems in the literature. Finally, a design-optimization study of two different cylindrical shells subject to uniform axial compression is presented.

McGowan, David M.; Anderson, Melvin S.

1998-01-01

237

The last recession was good for life expectancy.  

PubMed

Most people think that economic growth and a good economy are prerequisites for good health and high life expectancy. As such, a recession should decrease life expectancy or stop it from rising. In fact, recessions can boost life expectancy. This was the case during the Great Depression in the United States from 1929 to 1932 and during the recession in the European Union in 2009. In 2009, life expectancy increased most rapidly in European countries where the decrease in gross domestic product was greatest-Estonia, Latvia, and Lithuania. Studies of life expectancy increasing during recessions can yield valuable information regarding extending average life expectancy without essential costs. PMID:22533416

Kristjuhan, Ulo; Taidre, Erika

2012-04-01

238

Multivariate curve resolution for the analysis of remotely sensed thermal infrared hyperspectral images.  

SciTech Connect

While hyperspectral imaging systems are increasingly used in remote sensing and offer enhanced scene characterization relative to univariate and multispectral technologies, it has proven difficult in practice to extract all of the useful information from these systems due to overwhelming data volume, confounding atmospheric effects, and the limited a priori knowledge regarding the scene. The need exists for the ability to perform rapid and comprehensive data exploitation of remotely sensed hyperspectral imagery. To address this need, this paper describes the application of a fast and rigorous multivariate curve resolution (MCR) algorithm to remotely sensed thermal infrared hyperspectral images. Employing minimal a priori knowledge, notably non-negativity constraints on the extracted endmember profiles and a constant abundance constraint for the atmospheric upwelling component, it is demonstrated that MCR can successfully compensate thermal infrared hyperspectral images for atmospheric upwelling and, thereby, transmittance effects. We take a semi-synthetic approach to obtaining image data containing gas plumes by adding emission gas signals onto real hyperspectral images. MCR can accurately estimate the relative spectral absorption coefficients and thermal contrast distribution of an ammonia gas plume component added near the minimum detectable quantity.

Haaland, David Michael; Stork, Christopher Lyle; Keenan, Michael Robert

2004-07-01

239

Vertically stratified two-phase flow in a curved channel: Insights from a domain perturbation analysis  

NASA Astrophysics Data System (ADS)

In this work, we investigate the fully developed flow field of two vertically stratified fluids (one phase flowing above the other) in a curved channel of rectangular cross section. The domain perturbation technique is applied to obtain an analytical solution in the asymptotic limit of low Reynolds numbers and small curvature ratios (the ratio of the width of the channel to its radius of curvature). The accuracy of this solution is verified by comparison with numerical simulations of the nonlinear equations. The flow is characterized by helical vortices within each fluid, which are driven by centrifugal forces. The number of vortices and their direction of circulation varies with the parameters of the system (the volume fraction, viscosity ratio, and Reynolds numbers). We identify nine distinct flow patterns and organize the parameter space into corresponding flow regimes. We show that the fully developed interface between the fluids is not horizontal, in general, but is deformed by normal stresses associated with the circulatory flow. The results are especially significant for flows in microchannels, where the Reynolds numbers are small. The mathematical results in this paper include an analytical solution to two coupled biharmonic partial differential equations; these equations arise in two-phase, two-dimensional Stokes flows.

Garg, P.; Picardo, J. R.; Pushpavanam, S.

2014-07-01

240

Numerical analysis of thermal creep flow in curved channels for designing a prototype of Knudsen micropump  

NASA Astrophysics Data System (ADS)

The possibility to generate a gas flow inside a channel just by imposing a tangential temperature gradient along the walls without the existence of an initial pressure difference is well known. The gas must be under rarefied conditions, meaning that the system must operate between the slip and the free molecular flow regimes, either at low pressure or/and at micro/nano-scale dimensions. This phenomenon is at the basis of the operation principle of Knudsen pumps, which are actually compressors without any moving parts. Nowadays, gas flows in the slip flow regime through microchannels can be modeled using commercial Computational Fluid Dynamics softwares, because in this regime the compressible Navier-Stokes equations with appropriate boundary conditions are still valid. A simulation procedure has been developed for the modeling of thermal creep flow using ANSYS Fluent®. The implementation of the boundary conditions is achieved by developing User Defined Functions (UDFs) by means of C++ routines. The complete first order velocity slip boundary condition, including the thermal creep effects due to the axial temperature gradient and the effect of the wall curvature, and the temperature jump boundary condition are applied. The developed simulation tool is used for the preliminary design of Knudsen micropumps consisting of a sequence of curved and straight channels.

Leontidis, V.; Brandner, J. J.; Baldas, L.; Colin, S.

2012-05-01

241

Bayesian Analysis of Multivariate Latent Curve Models With Nonlinear Longitudinal Latent Effects  

PubMed Central

In longitudinal studies, investigators often measure multiple variables at multiple time points and are interested in investigating individual differences in patterns of change on those variables. Furthermore, in behavioral, social, psychological, and medical research, investigators often deal with latent variables that cannot be observed directly and should be measured by 2 or more manifest variables. Longitudinal latent variables occur when the corresponding manifest variables are measured at multiple time points. Our primary interests are in studying the dynamic change of longitudinal latent variables and exploring the possible interactive effect among the latent variables. Much of the existing research in longitudinal studies focuses on studying change in a single observed variable at different time points. In this article, we propose a novel latent curve model (LCM) for studying the dynamic change of multivariate manifest and latent variables and their linear and interaction relationships. The proposed LCM has the following useful features: First, it can handle multivariate variables for exploring the dynamic change of their relationships, whereas conventional LCMs usually consider change in a univariate variable. Second, it accommodates both first- and second-order latent variables and their interactions to explore how changes in latent attributes interact to produce a joint effect on the growth of an outcome variable. Third, it accommodates both continuous and ordered categorical data, and missing data. PMID:20016757

Song, Xin-Yuan; Lee, Sik-Yum; Hser, Yih-Ing

2009-01-01

242

Gene Scanning of an Internalin B Gene Fragment Using High-Resolution Melting Curve Analysis as a Tool for Rapid Typing of Listeria monocytogenes  

PubMed Central

The ability to accurately track Listeria monocytogenes strains involved in outbreaks is essential for control and prevention of listeriosis. Because current typing techniques are time-consuming, cost-intensive, technically demanding, and difficult to standardize, we developed a rapid and cost-effective method for typing of L. monocytogenes. In all, 172 clinical L. monocytogenes isolates and 20 isolates from culture collections were typed by high-resolution melting (HRM) curve analysis of a specific locus of the internalin B gene (inlB). All obtained HRM curve profiles were verified by sequence analysis. The 192 tested L. monocytogenes isolates yielded 15 specific HRM curve profiles. Sequence analysis revealed that these 15 HRM curve profiles correspond to 18 distinct inlB sequence types. The HRM curve profiles obtained correlated with the five phylogenetic groups I.1, I.2, II.1, II.2, and III. Thus, HRM curve analysis constitutes an inexpensive assay and represents an improvement in typing relative to classical serotyping or multiplex PCR typing protocols. This method provides a rapid and powerful screening tool for simultaneous preliminary typing of up to 384 samples in approximately 2 hours. PMID:21227395

Pietzka, Ariane T.; Stöger, Anna; Huhulescu, Steliana; Allerberger, Franz; Ruppitsch, Werner

2011-01-01

243

A/C(i) curve analysis across a range of woody plant species: influence of regression analysis parameters and mesophyll conductance.  

PubMed

The analysis and interpretation of A/C(i) curves (net CO(2) assimilation rate, A, versus calculated substomatal CO(2) concentration, C(i)) is dependent upon a number of underlying assumptions. The influence of the C(i) value at which the A/C(i) curve switches between the Rubisco- and electron transport-limited portions of the curve was examined on A/C(i) curve parameter estimates, as well as the effect of mesophyll CO(2) conductance (g(m)) values on estimates of the maximum rate of Rubisco-mediated carboxylation (V(cmax)). Based on an analysis using 19 woody species from the Pacific Northwest, significant variation occurred in the C(i) value where the Rubisco- and electron transport-limited portions of the curve intersect (C(i_t)), ranging from 20 Pa to 152 Pa and averaging c. 71 Pa and 37 Pa for conifer and broadleaf species, respectively. Significant effects on estimated A/C(i) parameters (e.g. V(cmax)) may arise when preliminary estimates of C(i_t), necessary for the multiple regression analyses, are set either too high or too low. However, when the appropriate threshold is used, a significant relationship between A/C(i) and chlorophyll fluorescence estimates of carboxylation is achieved. The use of the V(cmax) parameter to describe accurately the Rubisco activity from the A/C(i) curve analysis is also dependent upon the assumption that C(i) is approximately equal to chloroplast CO(2) concentrations (C(c)). If leaf mesophyll conductance is low, C(c) will be much lower than C(i) and will result in an underestimation of V(cmax) from A/C(i) curves. A large range of mesophyll conductance (g(m)) values was observed across the 19 species (0.005+/-0.002 to 0.189+/-0.011 mol m(-2) s(-1) for Tsuga heterophylla and Quercus garryana, respectively) and, on average, g(m) was 1.9 times lower for the conifer species (0.058+/-0.017 mol m(-2) s(-1) for conifers versus 0.112+/-0.020 mol m(-2) s(-1) for broadleaves). When this mesophyll limitation was accounted for in V(cmax) estimates, considerable variation still existed between species, but the difference in V(cmax) between conifer and broadleaf species was reduced from c. 11 micromol m(-2) s(-1) to 4 micromol m(-2) s(-1). For example, A/C(i) curve estimates of V(cmax) were 31.2+/-6.2 and 42.2+/-4.4 micromol m(-2) s(-1), and A/C(c) curve estimates were 41.2+/-7.1 micromol m(-2) s(-1) and 45.0+/-4.8 micromol m(-2) s(-1), for the conifer and broadleaf species, respectively. PMID:15501912

Manter, Daniel K; Kerrigan, Julia

2004-12-01

244

Observations, light curves analysis and pulsation behavior of the Algol-type eclipsing binary system XX Cep  

NASA Astrophysics Data System (ADS)

We present the long term photometric variations of the classical Algol type binary XX Cep with a ? Scuti type pulsating component. Modeling of the system shows that the secondary component fills its Roche lobe. The derived physical and geometrical parameters of the system are M1=1.92M?, M2=0.36M?, R1=2.08R?, R2=2.39R?, L1=19.8L?, L2=2.1L?, a=9.8R? and the distance of the system as 312(18) pc. We obtained five new times of minima. Analysis of the mid-eclipse times indicate a period decrease of dP/dt=-1.9(2)×10-8 days/yr that can be interpreted in terms of a mass transfer rate (dM/dt=-1.2(3)×10-9M?/yr) from the secondary to primary component. The O-C diagram formed from all available timings, and thus the orbital period of the system, can be partly represented as a beat effect between two cyclical variations with different periods (P1 = 48(1) yr, P2 = 81(4) yr). We used PHOEBE program for light curves analysis and after modeling, the eclipse and proximity effects were removed from the light curves to analyze intrinsic variations caused by components of the system. Frequency analysis was done by Period04 and the residuals represent the pulsation of a more massive component of the system XX Cep with a period of 0.031 days, confirming the results of Lee et al. (2007).

Hosseinzadeh, B.; Pazhouhesh, R.; Yakut, K.

2014-02-01

245

Recessive Mutations in LEPREL1 Underlie a Recognizable Lens Subluxation Phenotype.  

PubMed

Abstract Purpose: To uncover the homozygous recessive gene mutation underlying familial lens subluxation and/or juvenile lens opacities in four sisters from a consanguineous family. Methods: Prospective family study (clinical phenotyping; homozygosity-analysis-guided candidate gene testing). Results: The proband was a 14-year-old girl with long-standing poor vision, bilateral temporal lens subluxation, lens opacities, and axial high myopia. There were no syndromic findings, and fibrillin-1 sequencing was normal. Three sisters, also non-syndromic, had undergone bilateral juvenile lens surgery (two for juvenile cataract, 1 for lens subluxation) within the first two decades of life. Both sisters who had cataract surgery developed bilateral post-operative retinal detachments and one had documented lens instability during cataract surgery. Genetic analysis revealed the phenotype to segregate with a novel homozygous recessive mutation in LEPREL1 (c.292delC; p.Gly100Alafs*104). Recessive mutations in this gene were recently highlighted as a cause for axial myopia and early-onset cataract in two families for whom some affected members also had ectopia lentis and/or post-operative retinal detachments. Conclusions: Recessive LEPREL1 mutations should be recognized as part of the differential diagnosis of lens subluxation. The associated phenotype is non-syndromic and distinguishable from other causes of ectopia lentis in the context of its additional features: juvenile lens opacities, axial myopia, and a predisposition to retinal tears/detachment following intraocular surgery. PMID:25469533

Khan, Arif O; Aldahmesh, Mohammed A; Alsharif, Hadeel; Alkuraya, Fowzan S

2014-12-01

246

Analysis of stellar occultation data - Effects of photon noise and initial conditions. [planetary atmosphere temperature, pressure and density profiles from occultation light curve  

NASA Technical Reports Server (NTRS)

An occultation light curve can be analyzed to provide information about a planetary atmosphere. Temperature, pressure, and number density profiles for the atmosphere of Mars are derived from a series of boundary layer equations, which invert equal increments of altitude (as opposed to time) in order to predict the noise quality of the occultation. Numerical results are given for a noisy isothermal light curve, with special attention to error analysis.

French, R. G.; Elliot, J. L.; Gierasch, P. J.

1978-01-01

247

Light Curves  

NSDL National Science Digital Library

This is a game about light curves that will test your ability to figure out things about an asteroid from just a graph of its brightness. Astronomers use telescopes to collect light curves - measurements of the brightness of distant asteroids over time. It is part of the Killer Asteroids Web Site. The site also features a background overview of the differences between asteroids and comets, information on different types of asteroids (rubble piles vs monoliths), a discussion of how at risk Earth really is to an asteroid or comet impact, and background information on light curves.

248

Vibrational spectroscopic image analysis of biological material using multivariate curve resolution-alternating least squares (MCR-ALS).  

PubMed

Raman and Fourier transform IR (FTIR) microspectroscopic images of biological material (tissue sections) contain detailed information about their chemical composition. The challenge lies in identifying changes in chemical composition, as well as locating and assigning these changes to different conditions (pathology, anatomy, environmental or genetic factors). Multivariate data analysis techniques are ideal for decrypting such information from the data. This protocol provides a user-friendly pipeline and graphical user interface (GUI) for data pre-processing and unmixing of pixel spectra into their contributing pure components by multivariate curve resolution-alternating least squares (MCR-ALS) analysis. The analysis considers the full spectral profile in order to identify the chemical compounds and to visualize their distribution across the sample to categorize chemically distinct areas. Results are rapidly achieved (usually <30-60 min per image), and they are easy to interpret and evaluate both in terms of chemistry and biology, making the method generally more powerful than principal component analysis (PCA) or heat maps of single-band intensities. In addition, chemical and biological evaluation of the results by means of reference matching and segmentation maps (based on k-means clustering) is possible. PMID:25569330

Felten, Judith; Hall, Hardy; Jaumot, Joaquim; Tauler, Romà; de Juan, Anna; Gorzsás, András

2015-02-01

249

Heptaplex PCR melting curve analysis for rapid detection of plasmid-mediated AmpC ?-lactamase genes.  

PubMed

Antimicrobial resistance mediated by plasmid-borne AmpC ?-lactamase in Gram-negative bacteria is an emerging event of significant clinical importance. Rapid and reliable detection of ampC is in urgent need for appropriate infection control. We described the development and evaluation of a heptaplex PCR melting curve analysis that could identify six groups of ampC, i.e., CIT, EBC, DHA, ACC, MOX and FOX, through predefined melting temperatures. The entire analysis could be finished within 2h for 96 samples after template DNA was prepared. We first evaluated the assay with 176 AmpC-producing isolates of Escherichia coli and Klebsiella pneumoniae, and the results showed that 36 isolates were positive for ampC, including 18 positive for DHA, 12 for CIT, 5 for EBC, and one for both DHA and EBC. These results were fully concordant with sequencing analysis whereas the comparison method, an electrophoresis-based singleplex PCR assay, missed four isolates. The assay was also used to analyze 429 randomly selected clinically relevant Gram-negative isolates involving 22 different species, and 34 isolates were found to be ampC-positive. The results again fully agreed with the sequencing analysis. We conclude that the established assay could be used for rapid and reliable detection of ampC. PMID:25546843

Liu, Zanzan; Zhang, Jiaqin; Rao, Shitao; Sun, Li; Zhang, Jie; Liu, Ran; Zheng, Gangsen; Ma, Xiaobo; Hou, Shuyi; Zhuang, Xinguo; Song, Xiuyu; Li, Qingge

2015-03-01

250

Extraction of a plasma time-activity curve from dynamic brain PET images based on independent component analysis.  

PubMed

A compartment model has been used for kinetic analysis of dynamic positron emission tomography (PET) data [e.g., 2-deoxy-2-18F-fluoro-D-glucose (FDG)]. The input function of the model [the plasma time-activity curve (pTAC)] was obtained by serial arterial blood sampling. It is of clinical interest to develop a method for PET studies that estimates the pTAC without needing serial arterial blood sampling. For this purpose, we propose a new method to extract the pTAC from the dynamic brain PET images using a modified independent component analysis [extraction of the pTAC using independent component analysis (EPICA). Source codes of EPICA are freely available at http://www5f.biglobe.ne.jp/?kimura/Software/top.html]. EPICA performs the appropriate preprocessing and independent component analysis (ICA) using an objective function that takes the various properties of the pTAC into account. After validation of EPICA by computer simulation, EPICA was applied to human brain FDG-PET studies. The results imply that the EPICA-estimated pTAC was similar to the actual measured pTAC, and that the estimated blood volume image was highly correlated with the blood volume image measured using 15O-CO inhalation. These results demonstrated that EPICA is useful for extracting the pTAC from dynamic PET images without the necessity of serial arterial blood sampling. PMID:15709657

Naganawa, Mika; Kimura, Yuichi; Ishii, Kenji; Oda, Keiichi; Ishiwata, Kiichi; Matani, Ayumu

2005-02-01

251

Children's Recess Physical Activity: Movement Patterns and Preferences  

ERIC Educational Resources Information Center

The benefits of recess can be reaped by all students regardless of socioeconomic status, race, or gender and at relatively little cost. The purpose of this study was to examine physical activity (PA) variables related to the recess PA patterns of third and fourth grade children and the social preferences and individuals influencing their PA…

Woods, Amelia Mays; Graber, Kim C.; Daum, David Newman

2012-01-01

252

Mountain Monitor Tracking Economic Recession and Recovery in  

E-print Network

Mountain Monitor Tracking Economic Recession and Recovery in the Intermountain West's Metropolitan in the major metropolitan areas of the Mountain West in the fourth quarter of 2012. The region's employment;MOUNTAIN MONITOR: 4TH QUARTER 2012 2 Introduction The national recession officially ended in June 2009, yet

Hemmers, Oliver

253

Selecting a Linear Mixed Model for Longitudinal Data: Repeated Measures Analysis of Variance, Covariance Pattern Model, and Growth Curve Approaches  

Microsoft Academic Search

With increasing popularity, growth curve modeling is more and more often considered as the 1st choice for analyzing longitudinal data. Although the growth curve approach is often a good choice, other modeling strategies may more directly answer questions of interest. It is common to see researchers fit growth curve models without considering alterative modeling strategies. In this article we compare

Siwei Liu; Michael J. Rovine; Peter C. M. Molenaar

2012-01-01

254

Adolescents’ physical activity at recess and actions to promote a physically active school day in four Finnish schools  

PubMed Central

The national Finnish Schools on the Move programme support schools with their individual plans to promote school-based physical activity (PA). We examined the changes in adolescents’ recess and overall PA in four lower secondary schools and described the school actions to promote students’ PA and the local contact persons’ perceptions of the effects. Recess and overall PA were assessed four times by anonymous questionnaires from students in grades 7–9 (n = 789) in 2010–12, and local contact persons (n = 7) provided information on school actions with diaries, interviews and surveys. Student data were analysed with descriptive statistics and chi-square tests, and school actions data were analysed with quantitative content analysis. The proportion of students who participated in physical activities at recess at least sometimes increased from 30% to 49% in physically active play and from 33% to 42% in ball games, mostly due to improvements in males’ participation. Females’ participation in recess activities increased in two schools with gender-specific physical activities or facilities. Overall PA levels declined slightly. Organized recess activities, student recess activators and equipment provision and sports facilities development were considered to have affected students’ PA positively. Solutions for getting females more physically active in the school setting are needed. PMID:24906635

Haapala, H. L.; Hirvensalo, M. H.; Laine, K.; Laakso, L.; Hakonen, H.; Lintunen, T.; Tammelin, T. H.

2014-01-01

255

New approaches to direct gradient analysis using environmental scalars and statistical curve-fitting procedures  

Microsoft Academic Search

The conceptual framework of direct gradient analysis (DGA) is discussed in relation to the functional, factorial approach to vegetation. Both approaches use abstract simplified environment gradients with which to correlate vegetation response. Environmental scalars based on physical process models of environment and\\/or known biological growth processes can be incorporated to make analyses less location specific. An example of an environmental

M. P. Austin; R. B. Cunningham; P. M. Fleming

1984-01-01

256

Applying Decline Curve Analysis in the Liquid-rich Shales: Eagle Ford Shale Study  

E-print Network

, it is essential to identify or to estimate the time to reach BDF and to discontinue use of transient flow models after BDF appears or is expected. We validated our methodology using “hindcast analysis”; that is, matching the first half of production history...

Indras, Purvi

2014-01-09

257

COLD-PCR enhanced melting curve analysis improves diagnostic accuracy for KRAS mutations in colorectal carcinoma  

Microsoft Academic Search

BACKGROUND: KRAS mutational analysis is the standard of care prior to initiation of treatments targeting the epidermal growth factor receptor (EGFR) in patients with metastatic colorectal cancer. Sensitive methods are required to reliably detect KRAS mutations in tumor samples due to admixture with non-mutated cells. Many laboratories have implemented sensitive tests for KRAS mutations, but the methods often require expensive

Colin C Pritchard; Laura Akagi; Poluru L Reddy; Loren Joseph; Jonathan F Tait

2010-01-01

258

High-throughput real-time PCR and melt curve analysis for sexing Southern Ocean seabirds using fecal samples.  

PubMed

Sex identification of birds is of great interest in ecological studies, however this can be very difficult in many species because their external features are almost monomorphic between the sexes. Molecular methodology has simplified this process but limitations still occur with widely accepted methods using polymerase chain reaction and gel electrophoresis, especially when applied to degraded DNA. Real-time polymerase chain reaction assays are emerging as a more efficient, sensitive, and higher throughput means of identification, but there are very few techniques validated using fecal samples and small target sizes. We present a real-time melt curve analysis assay targeting a small region of the CHD-1 gene allowing for high-throughput, sensitive, specific, and easy-to-interpret sexing results for a variety of Southern Ocean seabirds using fecal and tissue samples. PMID:24507073

Faux, Cassandra E; McInnes, Julie C; Jarman, Simon N

2014-04-01

259

Statistical methods for pavement performance curve building, historical analysis, data sampling and storage. Final report, May 1997--July 1998  

SciTech Connect

The use of a pavement management system provides a state highway agency with the tools necessary to conduct a multi-year analysis of the maintenance and rehabilitation needs within the state based on both current needs and expected future conditions. In order to adequately predict future conditions, pavement performance models must be developed to reflect the deterioration trends of the agency`s pavements. At the time the SDDOT pavement management system was implemented in 1994, the Department developed a new condition rating system to evaluate the existing conditions of the state maintained pavements. At the same time, expert-based pavement performance models were developed to approximate the deterioration patterns of the highways based on pavement families (groupings of pavements with similar characteristics). A recommendation from that study (SD93-14) was to update the curves based on historical performance once sufficient data had been collected.

Zimmerman, K.A.; Bahulkar, A.M.

1998-08-01

260

An exome sequencing strategy to diagnose lethal autosomal recessive disorders.  

PubMed

Rare disorders resulting in prenatal or neonatal death are genetically heterogeneous. For some conditions, affected fetuses can be diagnosed by ultrasound scan, but this is not usually possible until mid-gestation. There is often limited fetal DNA available for investigation. We investigated a strategy for diagnosing autosomal recessive lethal disorders in non-consanguineous pedigrees with multiple affected fetuses. Exome sequencing was performed to identify genes where each parent is heterozygous for a rare non-synonymous-coding or splicing variant. Putative pathogenic variants were tested for cosegregation in affected fetuses and unaffected siblings. In eight couples of European ancestry, we found on average 1.75 genes (range 0-4) where both parents were heterozygous for rare potentially deleterious variants. A proof-of-principle study detected heterozygous DYNC2H1 variants in a couple whose five fetuses had short-rib polydactyly. Prospective analysis of two couples with multiple pregnancy terminations for fetal akinesia syndrome was performed and a diagnosis was obtained in both the families. The first couple were each heterozygous for a previously reported GLE1 variant, p.Arg569His or p.Val617Met; both were inherited by their two affected fetuses. The second couple were each heterozygous for a novel RYR1 variant, c.14130-2A>G or p.Ser3074Phe; both were inherited by their three affected fetuses but not by their unaffected child. Biallelic GLE1 and RYR1 disease-causing variants have been described in other cases with fetal akinesia syndrome. We conclude that exome sequencing of parental samples can be an effective tool for diagnosing lethal recessive disorders in outbred couples. This permits early prenatal diagnosis in future pregnancies. PMID:24961629

Ellard, Sian; Kivuva, Emma; Turnpenny, Peter; Stals, Karen; Johnson, Matthew; Xie, Weijia; Caswell, Richard; Lango Allen, Hana

2015-03-01

261

New light curves and analysis of the short-period Algol XZ Canis Minoris  

NASA Astrophysics Data System (ADS)

We present new observations of the short-period Algol XZ Canis Minoris made between 25 Dec. 1992 and 1 Mar. 1993. Two new epochs of minimum light were determined and an improved ephemeris is given. Analysis of the observations with the latest version of the Wilson-Devinney program shows that the system is semidetached. Our solution does not indicate the presence of third light, whereas some previously published solutions required large amounts of third light.

Terrell, Dirk; Gunn, J. B.; Kaiser, Daniel H.

1994-02-01

262

InTube DNA Methylation Profiling by Fluorescence Melting Curve Analysis  

Microsoft Academic Search

Background: Most PCR assays for detection of 5-meth- ylcytosine in genomic DNA entail a two-step procedure, comprising initial PCR amplification and subsequent product analysis in separate operations that usually require manual transfer. These methods generally pro- vide information about methylation of only a few CpG dinucleotides within the target sequence. Methods: An in-tube methylation assay is described that integrates amplification

Jesper Worm; Anni Aggerholm; Per Guldberg

2001-01-01

263

BAYESIAN WAVELET-BASED CURVE CLASSIFICATION VIA DISCRIMINANT ANALYSIS WITH MARKOV RANDOM TREE PRIORS  

PubMed Central

Discriminant analysis is an effective tool for the classification of experimental units into groups. When the number of variables is much larger than the number of observations it is necessary to include a dimension reduction procedure into the inferential process. Here we present a typical example from chemometrics that deals with the classification of different types of food into species via near infrared spectroscopy. We take a nonparametric approach by modeling the functional predictors via wavelet transforms and then apply discriminant analysis in the wavelet domain. We consider a Bayesian conjugate normal discriminant model, either linear or quadratic, that avoids independence assumptions among the wavelet coefficients. We introduce latent binary indicators for the selection of the discriminatory wavelet coefficients and propose prior formulations that use Markov random tree (MRT) priors to map scale-location connections among wavelets coefficients. We conduct posterior inference via MCMC methods, we show performances on our case study on food authenticity and compare results to several other procedures.. PMID:24761126

Stingo, Francesco C.; Vannucci, Marina; Downey, Gerard

2014-01-01

264

What can we learn from the Fourier analysis of blazar light curves?  

NASA Astrophysics Data System (ADS)

Blazars display strong variability on multiple timescales and in multiple radiation bands. Their variability can be characterized by power spectral densities (PSDs) and time lags as a function of Fourier frequency. We develop a new theoretical model based on analysis of the electron continuity equation carried out in the Fourier domain. This model predicts features in the synchrotron, synchrotron self-Compton (SSC), and external Compton (EC) PSDs and time lags associated with electron cooling, escape, and light travel time effects across the electromagnetic spectrum, from sub-mm to gamma-rays. We also find that FSRQs should have steeper PSD power-law indices than BL Lac objects at low Fourier frequencies if FSRQs produce gamma-rays by EC and BL Lac objects by SSC emission, in qualitative agreement with reported observations by the Fermi Large Area Telescope.

Finke, Justin

2015-01-01

265

What can we learn from the Fourier analysis of blazar light curves?  

NASA Astrophysics Data System (ADS)

Blazars display strong variability on multiple timescales and in multiple radiation bands. Their variability can be characterized by power spectral densities (PSDs) and time lags as a function of Fourier frequency. We develop a new theoretical model based on analysis of the electron continuity equation carried out in the Fourier domain. This model predicts features in the synchrotron, synchrotron self-Compton (SSC), and external Compton (EC) PSDs and time lags associated with electron cooling, escape, and light travel time effects across the electromagnetic spectrum, from sub-mm to gamma-rays. We also find that FSRQs should have steeper PSD power-law indices than BL Lac objects at low Fourier frequencies if FSRQs produce gamma-rays by EC and BL Lac objects by SSC emission, in qualitative agreement with reported observations by the Fermi Large Area Telescope.

Finke, Justin; Becker, Peter A.

2014-08-01

266

Cone-beam computed tomography analysis of curved root canals after mechanical preparation with three nickel-titanium rotary instruments  

PubMed Central

Cone beam computed tomography is a 3-dimensional high resolution imaging method. The purpose of this study was to compare the effects of 3 different NiTi rotary instruments used to prepare curved root canals on the final shape of the curved canals and total amount of root canal transportation by using cone-beam computed tomography. A total of 81 mesial root canals from 42 extracted human mandibular molars, with a curvature ranging from 15 to 45 degrees, were selected. Canals were randomly divided into 3 groups of 27 each. After preparation with Protaper, Revo-S and Hero Shaper, the amount of transportation and centering ability that occurred were assessed by using cone beam computed tomography. Utilizing pre- and post-instrumentation radiographs, straightening of the canal curvatures was determined with a computer image analysis program. Canals were metrically assessed for changes (surface area, changes in curvature and transportation) during canal preparation by using software SimPlant; instrument failures were also recorded. Mean total widths and outer and inner width measurements were determined on each central canal path and differences were statistically analyzed. The results showed that all instruments maintained the original canal curvature well with no significant differences between the different files (P = 0.226). During preparation there was failure of only one file (the protaper group). In conclusion, under the conditions of this study, all instruments maintained the original canal curvature well and were safe to use. Areas of uninstrumented root canal wall were left in all regions using the various systems. PMID:23885273

Elsherief, Samia M.; Zayet, Mohamed K.; Hamouda, Ibrahim M.

2013-01-01

267

Urbanization and the global malaria recession  

PubMed Central

Background The past century has seen a significant contraction in the global extent of malaria transmission, resulting in over 50 countries being declared malaria free, and many regions of currently endemic countries eliminating the disease. Moreover, substantial reductions in transmission have been seen since 1900 in those areas that remain endemic today. Recent work showed that this malaria recession was unlikely to have been driven by climatic factors, and that control measures likely played a significant role. It has long been considered, however, that economic development, and particularly urbanization, has also been a causal factor. The urbanization process results in profound socio-economic and landscape changes that reduce malaria transmission, but the magnitude and extent of these effects on global endemicity reductions are poorly understood. Methods Global data at subnational spatial resolution on changes in malaria transmission intensity and urbanization trends over the past century were combined to examine the relationships seen over a range of spatial and temporal scales. Results/Conclusions A consistent pattern of increased urbanization coincident with decreasing malaria transmission and elimination over the past century was found. Whilst it remains challenging to untangle whether this increased urbanization resulted in decreased transmission, or that malaria reductions promoted development, the results point to a close relationship between the two, irrespective of national wealth. The continuing rapid urbanization in malaria-endemic regions suggests that such malaria declines are likely to continue, particularly catalyzed by increasing levels of direct malaria control. PMID:23594701

2013-01-01

268

Other autosomal recessive and childhood ataxias.  

PubMed

The label of "early-onset cerebellar ataxia with retained tendon reflexes" (EOCA) has been created to differentiate it from Friedreich ataxia (FRDA) patients with preserved knee jerks and absence of cardiomyopathy, optic atrophy, and diabetes mellitus. However, EOCA is a heterogeneous syndrome and several FRDA patients present with an EOCA-like phenotype. Cerebellar ataxia with hypogonadism is another heterogeneous syndrome for which no locus has been mapped yet. Two peculiar ataxic syndromes have been identified in genetically isolated populations: autosomal recessive ataxia of Charlevoix-Saguenay (ARSACS) in Quebec and infantile-onset spinocerebellar ataxia (IOSCA) in Finland. Both conditions present usually within the second year of life. ARSACS is characterized by marked spasticity and IOSCA by a complex phenotype which includes, besides ataxia, epilepsy, optic atrophy, ophthalmoplegia, hearing loss, and areflexia. The responsible genes are SACS, encoding sacsin, a protein which may act as a chaperone, and C10orf2, encoding Twinkle, a mitochondrial DNA-specific helicase. Marinesco-Sjögren syndrome, clinically characterized by cerebellar ataxia, cataracts, myopathy, and mental retardation, is genetically heterogeneous. One gene, SIL1, encodes a nucleotide exchange factor for the heat-shock protein 70 chaperone HSPA5. Five conditions account for most cases of progressive myoclonic ataxia: Unverricht-Lundborg disease, Lafora disease, myoclonic epilepsy with ragged-red fibers, neuronal ceroid lipofuscinoses, and sialidoses. PMID:21827899

De Michele, Giuseppe; Filla, Alessandro

2012-01-01

269

Economic recession and mental health: an overview.  

PubMed

Effects of the current global economic downturn on population mental health will emerge in the years ahead. Judging from earlier experience of financial crises in various parts of the world, stresses associated with rising unemployment, poverty and social insecurity will lead to upward trends in many national suicide rates, as well as to less readily charted increase in the prevalence of psychiatric illness, alcohol-related disorders and illicit drug use. At the same time, mental health services are being cut back as part of government austerity programs. Budget cuts will thus affect psychiatric services adversely just when economic stressors are raising the levels of need and demand in affected populations. Proactive fiscal and social policies could, however, help to mitigate the health consequences of recession. Evidence- based preventive measures include active labor market and family support programs, regulation of alcohol prices and availability, community care for known high-risk groups, and debt relief projects. Economic mental health care could best be achieved, not by decimating services but by planning and deploying these to meet the needs of defined area populations. PMID:21968374

Cooper, Brian

2011-01-01

270

Mixed models and reduced/selective integration displacement models for nonlinear analysis of curved beams  

NASA Technical Reports Server (NTRS)

Simple mixed models are developed for use in the geometrically nonlinear analysis of deep arches. A total Lagrangian description of the arch deformation is used, the analytical formulation being based on a form of the nonlinear deep arch theory with the effects of transverse shear deformation included. The fundamental unknowns comprise the six internal forces and generalized displacements of the arch, and the element characteristic arrays are obtained by using Hellinger-Reissner mixed variational principle. The polynomial interpolation functions employed in approximating the forces are one degree lower than those used in approximating the displacements, and the forces are discontinuous at the interelement boundaries. Attention is given to the equivalence between the mixed models developed herein and displacement models based on reduced integration of both the transverse shear and extensional energy terms. The advantages of mixed models over equivalent displacement models are summarized. Numerical results are presented to demonstrate the high accuracy and effectiveness of the mixed models developed and to permit a comparison of their performance with that of other mixed models reported in the literature.

Noor, A. K.; Peters, J. M.

1981-01-01

271

Detection of Diarrheagenic Escherichia coli by Use of Melting-Curve Analysis and Real-Time Multiplex PCR ?  

PubMed Central

Diarrheagenic Escherichia coli strains are important causes of diarrhea in children from the developing world and are now being recognized as emerging enteropathogens in the developed world. Current methods of detection are too expensive and labor-intensive for routine detection of these organisms to be practical. We developed a real-time fluorescence-based multiplex PCR for the detection of all six of the currently recognized classes of diarrheagenic E. coli. The primers were designed to specifically amplify eight different virulence genes in the same reaction: aggR for enteroaggregative E. coli, stIa/stIb and lt for enterotoxigenic E. coli, eaeA for enteropathogenic E. coli and Shiga toxin-producing E. coli (STEC), stx1 and stx2 for STEC, ipaH for enteroinvasive E. coli, and daaD for diffusely adherent E. coli (DAEC). Eighty-nine of ninety diarrheagenic E. coli and 36/36 nonpathogenic E. coli strains were correctly identified using this approach (specificity, 1.00; sensitivity, 0.99). The single false negative was a DAEC strain. The total time between preparation of DNA from E. coli colonies on agar plates and completion of PCR and melting-curve analysis was less than 90 min. The cost of materials was low. Melting-point analysis of real-time multiplex PCR is a rapid, sensitive, specific, and inexpensive method for detection of diarrheagenic E. coli. PMID:18322059

Guion, Chase E.; Ochoa, Theresa J.; Walker, Christopher M.; Barletta, Francesca; Cleary, Thomas G.

2008-01-01

272

Iceland Glacier Recession 1973 to 2000, Glacier Terminus contrast emphasized  

NSDL National Science Digital Library

This animation shows glacier recesion at the Breidamerkurjokull glacier in Iceland. The data from 1973 is taken from Landsat 1 and the 2000 data is from Landsat 7. The Breidamerkurjokull glacier in Iceland has been measured by Landsat to be receding since 1973. The glacierologists in Iceland and here at Nasas Goddard Space Flight Center have measured the recession throughout the entire glacier and found different rates of recession in different areas. In genral, the glacier seems to be receding at about 2% annually. It is extremely controversial whether this recession is caused by global warming.

Perkins, Lori; Hall, Dorothy

2001-04-09

273

Economic recession and headache-related hospital admissions.  

PubMed

Incidence of headaches across different regions and its relationship to unemployment rates in the United States before and during an economic recession was evaluated. Years 2008 and 2009 were determined as recessionary period. Headache-related admissions, particularly the uncomplicated headaches, increased significantly during recession. Proportion of women with headaches has increased and the age group of 25-54 years was the most affected during the recession. The hospital charges have increased even though the average length and charge of stay decreased. These findings are consistent with our understanding of effects of stress and unemployment on psychological and physical health. PMID:23822548

Chinta, Ravi; Rao, M B; Narendran, Vivek; Malla, Ganesh; Joshi, Hem

2013-01-01

274

Detection, measurement and prediction of shoreline recession in Accra, Ghana  

NASA Astrophysics Data System (ADS)

Coastal mapping, using various data capture and feature extraction techniques, has furthered understanding of trends in shoreline evolution by allowing calculation of accurate historic rates of change that subsequently enable the prediction of future shoreline positions through different modelling procedures. The results have helped influence coastal policy formulation and promoted the development of sustainable management practices in coastal regions throughout the developed world. However, sustainable coastal management is rarely practiced in developing countries, one of the fundamental reasons for this being a general lack of reliable and accurate historic data on shoreline position. Previous studies on the Ghanaian coastal region of Accra, where accurate and reliable geospatial data for analysis is scarce, have reported erosion rates of anything between two and eight metres per year. This high level of inconsistency in reported rates has hindered effective and sustainable coastal management. The research reported in this paper addresses this issue, using mapping data from 1904, 1974, 1996 and 2002 to estimate, by linear regression, shoreline recession in the Accra region. Predictions for the next 250 yr were then undertaken using a variety of techniques ranging from a process-based numerical model, SCAPE, to geometric approaches including historical trend analysis, the modified Bruun model and Sunamura's shore platform model. Uncertainties in the various input data were accounted for, including historic recession rates, rock strength, sediment content and, importantly, future sea-level rise under different climate change scenarios. The mean historic rate of erosion in the Accra region was found to be 1.13 m/yr(±0.17 m/yr), significantly less than previously reported, though still very high. Subsequent predictions were used to identify a series of significant economic, ecological and social features at risk, and to estimate when they will most likely be lost to erosion if left unprotected. The case study illustrates that, provided suitable predictive models are selected and the uncertainties involved in working with limited data sets are dealt with appropriately, it is possible to provide statistical information in support of sustainable coastal management for developing countries in the face of a changing climate.

Appeaning Addo, K.; Walkden, M.; Mills, J. P.

275

Quantitative Fundus Autofluorescence in Recessive Stargardt Disease  

PubMed Central

Purpose. To quantify fundus autofluorescence (qAF) in patients with recessive Stargardt disease (STGD1). Methods. A total of 42 STGD1 patients (ages: 7–52 years) with at least one confirmed disease-associated ABCA4 mutation were studied. Fundus AF images (488-nm excitation) were acquired with a confocal scanning laser ophthalmoscope equipped with an internal fluorescent reference to account for variable laser power and detector sensitivity. The gray levels (GLs) of each image were calibrated to the reference, zero GL, magnification, and normative optical media density to yield qAF. Texture factor (TF) was calculated to characterize inhomogeneities in the AF image and patients were assigned to the phenotypes of Fishman I through III. Results. Quantified fundus autofluorescence in 36 of 42 patients and TF in 27 of 42 patients were above normal limits for age. Young patients exhibited the relatively highest qAF, with levels up to 8-fold higher than healthy eyes. Quantified fundus autofluorescence and TF were higher in Fishman II and III than Fishman I, who had higher qAF and TF than healthy eyes. Patients carrying the G1916E mutation had lower qAF and TF than most other patients, even in the presence of a second allele associated with severe disease. Conclusions. Quantified fundus autofluorescence is an indirect approach to measuring RPE lipofuscin in vivo. We report that ABCA4 mutations cause significantly elevated qAF, consistent with previous reports indicating that increased RPE lipofuscin is a hallmark of STGD1. Even when qualitative differences in fundus AF images are not evident, qAF can elucidate phenotypic variation. Quantified fundus autofluorescence will serve to establish genotype-phenotype correlations and as an outcome measure in clinical trials. PMID:24677105

Burke, Tomas R.; Duncker, Tobias; Woods, Russell L.; Greenberg, Jonathan P.; Zernant, Jana; Tsang, Stephen H.; Smith, R. Theodore; Allikmets, Rando; Sparrow, Janet R.; Delori, François C.

2014-01-01

276

Molecular mechanisms of autosomal recessive hypercholesterolemia.  

PubMed

Mutations in the phosphotyrosine-binding domain protein ARH cause autosomal recessive hypercholesterolemia (ARH), an inherited form of hypercholesterolemia due to a tissue-specific defect in the removal of low density lipoproteins (LDL) from the circulation. LDL uptake by the LDL receptor (LDLR) is markedly reduced in the liver but is normal or only moderately impaired in cultured fibroblasts of ARH patients. To define the molecular mechanism underlying ARH we examined ARH mRNA and protein in fibroblasts and lymphocytes from six probands with different ARH mutations. None of the probands had detectable full-length ARH protein in fibroblasts or lymphoblasts. Five probands were homozygous for mutations that introduced premature termination codons. No relationship was apparent between the site of the mutation in ARH and the amount of mRNA. The only mutation identified in the remaining proband was a SINE VNTR Alu (SVA) retroposon insertion in intron 1, which was associated with no detectable ARH mRNA. (125)I-LDL degradation was normal in ARH fibroblasts, as previously reported. In contrast, LDLR function was markedly reduced in ARH lymphoblasts, despite a 2-fold increase in LDL cell surface binding in these cells. These data indicate that all ARH mutations characterized to date preclude the synthesis of full-length ARH and that ARH is required for normal LDLR function in lymphocytes and hepatocytes, but not in fibroblasts. Residual LDLR function in cells that do not require ARH may explain why ARH patients have lower plasma LDL levels than do patients with homozygous familial hypercholesterolemia who have no functional LDLRs. PMID:12417523

Wilund, Kenneth R; Yi, Ming; Campagna, Filomena; Arca, Marcello; Zuliani, Giovanni; Fellin, Renato; Ho, Yiu-Kee; Garcia, J Victor; Hobbs, Helen H; Cohen, Jonathan C

2002-11-15

277

Common Autosomal Recessive Diseases in Oman Derived from a Hospital-Based Registry  

Microsoft Academic Search

Objectives: The local frequencies of genetic disorders in Oman apart from hemoglobinopathies are largely unknown. The aim of the present study was to evaluate birth prevalence of commonly diagnosed autosomal recessive diseases and to estimate needs and priorities of genetic services. Methods: Analysis of the years 1993–2002 using a hospital-based registry of genetic diseases was attempted. More than 3,000 records

A. Rajab; B. Bappal; H. Al-Shaikh; S. Al-Khusaibi; A. J. Mohammed

2005-01-01

278

Example of application of response history analysis for seismically isolated curved bridges on drilled shaft with springs representing soil  

Microsoft Academic Search

The main objective of this study is to perform a parametrical study associated with the effects of the earthquake ground motions on the seismic response of isolated curved bridges including soil–structure interaction.For the isolated bridge system, double concave friction pendulum bearings are placed between the deck and the piers, the abutments as isolation devices. A curved bridge is selected to

Sevket Ates; Michael C. Constantinou

2011-01-01

279

Ecology and Management of the Spring Snowmelt Recession  

NSDL National Science Digital Library

We present a conceptual model for the ecology of the spring snowmelt recession based on the natural flow regime that relates the quantifiable components of magnitude, timing, and rate of change to abiotic and biotic factors that govern riverine processes. We find that shifts in the magnitude of the recession largely affect abiotic channel conditions, whereas shifts in the timing of the snowmelt primarily affect biotic conditions. Shifts in the rate of change affect both abiotic and biotic conditions, creating the largest observed changes to the stream ecosystem. We discuss these components with regard to the success of riverine species in California's Mediterranean-montane environment. We then present two scenarios of change to the spring snowmelt recessionâÂÂeffects of flow regulation and climate warmingâÂÂand discuss their potential implications for riverine ecology. Our conceptual model can help guide watershed stakeholders toward a better understanding of the impacts of changing spring recession conditions on stream ecosystems.

Sarah Yarnell (University of California, Davis;Center for Watershed Studies)

2010-02-01

280

Chemical-mechanical polishing of recessed microelectromechanical devices  

DOEpatents

A method is disclosed for micromachining recessed layers (e.g. sacrificial layers) of a microelectromechanical system (MEMS) device formed in a cavity etched into a semiconductor substrate. The method uses chemical-mechanical polishing (CMP) with a resilient polishing pad to locally planarize one or more of the recessed layers within the substrate cavity. Such local planarization using the method of the present invention is advantageous for improving the patterning of subsequently deposited layers, for eliminating mechanical interferences between functional elements (e.g. linkages) of the MEMS device, and for eliminating the formation of stringers. After the local planarization of one or more of the recessed layers, another CMP step can be provided for globally planarizing the semiconductor substrate to form a recessed MEMS device which can be integrated with electronic circuitry (e.g., CMOS, BiCMOS or bipolar circuitry) formed on the surface of the substrate. 23 figs.

Barron, C.C.; Hetherington, D.L.; Montague, S.

1999-07-06

281

Chemical-mechanical polishing of recessed microelectromechanical devices  

DOEpatents

A method is disclosed for micromachining recessed layers (e.g. sacrificial layers) of a microelectromechanical system (MEMS) device formed in a cavity etched into a semiconductor substrate. The method uses chemical-mechanical polishing (CMP) with a resilient polishing pad to locally planarize one or more of the recessed layers within the substrate cavity. Such local planarization using the method of the present invention is advantageous for improving the patterning of subsequently deposited layers, for eliminating mechanical interferences between functional elements (e.g. linkages) of the MEMS device, and for eliminating the formation of stringers. After the local planarization of one or more of the recessed layers, another CMP step can be provided for globally planarizing the semiconductor substrate to form a recessed MEMS device which can be integrated with electronic circuitry (e.g. CMOS, BiCMOS or bipolar circuitry) formed on the surface of the substrate.

Barron, Carole C. (Albuquerque, NM); Hetherington, Dale L. (Albuquerque, NM); Montague, Stephen (Albuquerque, NM)

1999-01-01

282

38. RECESSED ARCH DETAIL WITH STONE SCONCE ON FRONT OF ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

38. RECESSED ARCH DETAIL WITH STONE SCONCE ON FRONT OF 1931 SECTION, PROJECTING SIDE BAY, TAKEN FROM THE NORTH. - James Russell Lowell Elementary School, 4501 Crittenden Drive, Louisville, Jefferson County, KY

283

Genetics Home Reference: Autosomal recessive axonal neuropathy with neuromyotonia  

MedlinePLUS

... Patients and Families Resources for Health Professionals What glossary definitions help with understanding autosomal recessive axonal neuropathy ... many other terms in the Genetics Home Reference Glossary . See also Understanding Medical Terminology . References (4 links) ...

284

Remote Recession Sensing of Ablative Heat Shield Materials  

NASA Technical Reports Server (NTRS)

Material recession and charring are two major processes determining the performance of ablative heat shield materials. Even in ground testing, the characterization of these two mechanisms relies on measurements of material thickness before and after testing, thus providing only information integrated over the test time. For recession measurements, optical methods such as imaging the sample surface during testing are under investigation but require high alignment and instrument effort, therefore being not established as a standard measurement method. For char depth measurements, the most common method so far consists in investigation of sectioned samples after testing or in the case of Stardust where core extractions were performed to determine char information. In flight, no reliable recession measurements are available, except total recession after recovering the heat shield on ground. Developments of mechanical recession sensors have been started but require substantial on board instrumentation adding mass and complexity. In this work, preliminary experiments to evaluate the feasibility of remote sensing of material recession and possibly char depth through optically observing the emission signatures of seeding materials in the post shock plasma is investigated. It is shown that this method can provide time resolved recession measurements without the necessity of accurate alignment procedures of the optical set-up and without any instrumentation on board of a spacecraft. Furthermore, recession data can be obtained without recovering flight hardware which would be a huge benefit for inexpensive heat shield material testing on board of small re-entry probes, e.g. on new micro-satellite re-entry probes as a possible future application of Cubesats or RBR

Winter, Michael W.; Stackpoole, Margaret; Nawaz, Anuscheh; Gonzales, Gregory Lewis; Ho, Thanh

2014-01-01

285

Children's Physical Activity during Recess and Outside of School  

ERIC Educational Resources Information Center

The purpose of this study was to examine children's physical activity during recess and outside of school. Third-, fourth-, and fifth-grade students (N = 270; 121 boys, age = 9.5 plus or minus 0.9 years; 150 girls, age = 9.6 plus or minus 0.9 years) wore sealed pedometers during a 15-minute recess period and outside of school for 4 consecutive…

Beighle, Aaron; Morgan, Charles F.; Le Masurier, Guy; Pangrazi, Robert P.

2006-01-01

286

Self-modeling curve resolution (SMCR) analysis of near-infrared (NIR) imaging data of pharmaceutical tablets.  

PubMed

The idea of quality by design (QbD) has been proposed in pharmaceutical field. QbD is a systematic approach to control the product performance based on the scientific understanding of the product quality and its manufacturing process. In the present study, near-infrared (NIR) imaging is utilized as a tool to achieve this concept. A practical use of a chemometrics technique called self-modeling curve resolution (SMCR) is demonstrated with NIR imaging analysis of pharmaceutical tablets containing two ingredients, a soluble active ingredient, pentoxifylline (PTX), and an insoluble excipient, palmitic acid. Concentration profiles obtained by SMCR reveal that the homogenous distribution of chemical ingredients strongly depends on the grinding time and that its process plays a central role in quantitative control, say sustained-release of PTX. In addition, pure component spectra by SMCR indicate a sequential change of specific NIR peak intensities following the increase of the grinding time. The spectra change shows a molecular structure change related to its crystallinity during grinding process. Accordingly, this study clearly demonstrates that NIR imaging combined with SMCR can be a powerful tool to reveal chemical or physical mechanism induced by the manufacturing process of pharmaceutical products and that it may be a solid solution for QbD of pharmaceutical products. PMID:18539178

Awa, Kimie; Okumura, Takehiro; Shinzawa, Hideyuki; Otsuka, Makoto; Ozaki, Yukihiro

2008-06-30

287

A Biometric Latent Curve Analysis of Memory Decline in Older Men of the NAS-NRC Twin Registry  

PubMed Central

Previous research has shown cognitive abilities to have different biometric patterns of age-changes. Here we examined the variation in episodic memory (Words Recalled) for over 6,000 twin pairs who were initially aged 59-75, and were subsequently re-assessed up to three more times over 12 years. In cross-sectional analyses, variation in Education was explained by strong additive genetic influences (~43%) together with shared family influences (~35%) that were independent of age. The longitudinal phenotypic analysis of the Word Recall task showed systematic linear declines over age, but with positive influences of Education and Retesting. The longitudinal biometric estimation yielded: (a) A separation of non-shared environmental influences and transient measurement error (~50%): (b) Strong additive genetic components of this latent curve (~70% at age 60) with increases over age that reach about 90% by age 90. (c) The minor influences of shared family environment (~17% at age 60) were effectively eliminated by age 75. (d) Non-shared environmental effects play an important role over most of the life-span (peak of 42% at age 70) but their relative role diminishes after age 75. PMID:19404731

McArdle, John J.; Plassman, Brenda L.

2010-01-01

288

Validation of Kepler's Multiple Planet Candidates. III. Light Curve Analysis and Announcement of Hundreds of New Multi-planet Systems  

NASA Astrophysics Data System (ADS)

The Kepler mission has discovered more than 2500 exoplanet candidates in the first two years of spacecraft data, with approximately 40% of those in candidate multi-planet systems. The high rate of multiplicity combined with the low rate of identified false positives indicates that the multiplanet systems contain very few false positive signals due to other systems not gravitationally bound to the target star. False positives in the multi-planet systems are identified and removed, leaving behind a residual population of candidate multi-planet transiting systems expected to have a false positive rate less than 1%. We present a sample of 340 planetary systems that contain 851 planets that are validated to substantially better than the 99% confidence level; the vast majority of these have not been previously verified as planets. We expect ~two unidentified false positives making our sample of planet very reliable. We present fundamental planetary properties of our sample based on a comprehensive analysis of Kepler light curves, ground-based spectroscopy, and high-resolution imaging. Since we do not require spectroscopy or high-resolution imaging for validation, some of our derived parameters for a planetary system may be systematically incorrect due to dilution from light due to additional stars in the photometric aperture. Nonetheless, our result nearly doubles the number verified exoplanets.

Rowe, Jason F.; Bryson, Stephen T.; Marcy, Geoffrey W.; Lissauer, Jack J.; Jontof-Hutter, Daniel; Mullally, Fergal; Gilliland, Ronald L.; Issacson, Howard; Ford, Eric; Howell, Steve B.; Borucki, William J.; Haas, Michael; Huber, Daniel; Steffen, Jason H.; Thompson, Susan E.; Quintana, Elisa; Barclay, Thomas; Still, Martin; Fortney, Jonathan; Gautier, T. N., III; Hunter, Roger; Caldwell, Douglas A.; Ciardi, David R.; Devore, Edna; Cochran, William; Jenkins, Jon; Agol, Eric; Carter, Joshua A.; Geary, John

2014-03-01

289

Entrepreneurship, Economic Conditions, and the Great Recession  

E-print Network

African-American Owned Business: An Analysis of the DynamicsSelf-Employment: A Dynamic Analysis of Business Ownership,"Business Start-Ups: Deutschmarks versus Dollars," Berkeley Electronic Journals, Contributions to Economic Analysis &

Fairlie, Rob

2011-01-01

290

Detecting differential allelic expression using high-resolution melting curve analysis: application to the breast cancer susceptibility gene CHEK2  

PubMed Central

Background The gene CHEK2 encodes a checkpoint kinase playing a key role in the DNA damage pathway. Though CHEK2 has been identified as an intermediate breast cancer susceptibility gene, only a small proportion of high-risk families have been explained by genetic variants located in its coding region. Alteration in gene expression regulation provides a potential mechanism for generating disease susceptibility. The detection of differential allelic expression (DAE) represents a sensitive assay to direct the search for a functional sequence variant within the transcriptional regulatory elements of a candidate gene. We aimed to assess whether CHEK2 was subject to DAE in lymphoblastoid cell lines (LCLs) from high-risk breast cancer patients for whom no mutation in BRCA1 or BRCA2 had been identified. Methods We implemented an assay based on high-resolution melting (HRM) curve analysis and developed an analysis tool for DAE assessment. Results We observed allelic expression imbalance in 4 of the 41 LCLs examined. All four were carriers of the truncating mutation 1100delC. We confirmed previous findings that this mutation induces non-sense mediated mRNA decay. In our series, we ruled out the possibility of a functional sequence variant located in the promoter region or in a regulatory element of CHEK2 that would lead to DAE in the transcriptional regulatory milieu of freely proliferating LCLs. Conclusions Our results support that HRM is a sensitive and accurate method for DAE assessment. This approach would be of great interest for high-throughput mutation screening projects aiming to identify genes carrying functional regulatory polymorphisms. PMID:21569354

2011-01-01

291

Development and analysis of regional curves for streams in the non-urban valley and ridge physiographic province, Maryland, Virginia, and West Virginia  

USGS Publications Warehouse

Regression relations for bankfull stream characteristics based on drainage area (often called 'regional curves') are used in natural stream channel design to verify field determinations of bankfull discharge and stream channel characteristics. Bankfull stream characteristics were assessed for stream reaches at 41 streamflow-gaging stations in the Valley and Ridge Physiographic Province in Maryland, Virginia, and West Virginia. Data collected included bankfull cross-sectional geometry, flood plain geometry, and longitudinal profile data. In addition, particle-size distributions of streambed material were determined and data on basin characteristics were compiled for each reach. Regional curves were developed for bankfull cross-sectional area, width, and discharge with R2 values of 0.95, 0.89, 0.87, and 0.91, respectively. Examination of the regional curves residuals indicates that there is more variability in bankfull cross-sectional area, width, and discharge for smaller streams than for larger streams. In contrast, there is more variability for bankfull mean depth for larger streams than for smaller streams. Geographic analysis of regional curve residuals indicated that there were no further subdivisions within the Valley and Ridge Physiographic Province in the three-state study area for which individual sets of regional curves should be developed. In addition, two separate sets of regional curves were developed with data from the 41 sites to examine potential differences in the relations between the southern (n = 9) and central (n = 32) sections of the province. There were differences in slope and intercept between the two bankfull discharge test relations and a difference in intercept for the width test relations at the 95-percent confidence level. However, the results of this analysis were inconclusive and therefore one set of regional curves for the study area is presented in this report. The regional curves were compared to regression models developed from similar data collected in the Pennsylvania and Maryland portions of the province. No statistical difference in the slope or intercept of regression lines of the three data sets was detected for any of the four bankfull parameters at the 95-percent confidence level. Basin characteristics such as percentage of basin forested (percent forested) and percentage of basin underlain by carbonate bedrock (percent carbonate) were analyzed to evaluate variability among regression points. Multivariate regression relations including explanatory terms for percent carbonate and drainage area produced higher R2 values than the regional curves for bankfull cross-sectional area (R2 = 0.95), bankfull width (R2 = 0.92), and bankfull discharge (R2 = 0.93). There was no improvement for the bankfull mean depth relation from adding the additional term. Inclusion of the other basin characteristics in multivariate relations did not improve the regression models. Regression models developed for the 1.5-year discharge for all streamflow-gaging stations with peak discharge data throughout Virginia (n = 486) and throughout the Valley and Ridge Physiographic Province in Virginia (n = 147) were compared to the regional curve relating bankfull discharge to drainage area. A similar trend in decreasing variability with increasing drainage area was observed for the 1.5-year discharge for all stations in Virginia . This indicates that the change in variability observed in the discharge regional curve likely would exist with a larger data set. There was no statistical difference at the 95-percent confidence level between regression relations for the southern section of the province (n = 40) and the central section (n = 107). This finding supports maintaining only one set of regional curves for the study area. Not all of the variability in the regional curves is explained by drainage area alone. Causes of the remaining variability likely vary among study sites. Users of the regional curves de

Keaton, Jefferson N.; Messinger, Terence; Doheny, Edward J.

2005-01-01

292

On the use of spring baseflow recession for a more accurate parameterization of aquifer transit time distribution functions  

NASA Astrophysics Data System (ADS)

Baseflow recession analysis and groundwater dating have up to now developed as two distinct branches of hydrogeology and were used to solve entirely different problems. We show that by combining two classical models, namely Boussinesq's Equation describing spring baseflow recession and the exponential piston-flow model used in groundwater dating studies, the parameters describing the transit time distribution of an aquifer can be in some cases estimated to a far more accurate degree than with the latter alone. Under the assumption that the aquifer basis is sub-horizontal, the mean residence time of water in the saturated zone can be estimated from spring baseflow recession. This provides an independent estimate of groundwater residence time that can refine those obtained from tritium measurements. This approach is demonstrated in a case study predicting atrazine concentration trend in a series of springs draining the fractured-rock aquifer known as the Luxembourg Sandstone. A transport model calibrated on tritium measurements alone predicted different times to trend reversal following the nationwide ban on atrazine in 2005 with different rates of decrease. For some of the springs, the best agreement between observed and predicted time of trend reversal was reached for the model calibrated using both tritium measurements and the recession of spring discharge during the dry season. The agreement between predicted and observed values was however poorer for the springs displaying the most gentle recessions, possibly indicating the stronger influence of continuous groundwater recharge during the dry period.

Farlin, J.; Maloszewski, P.

2012-12-01

293

On the use of spring baseflow recession for a more accurate parameterization of aquifer transit time distribution functions  

NASA Astrophysics Data System (ADS)

Baseflow recession analysis and groundwater dating have up to now developed as two distinct branches of hydrogeology and have been used to solve entirely different problems. We show that by combining two classical models, namely the Boussinesq equation describing spring baseflow recession, and the exponential piston-flow model used in groundwater dating studies, the parameters describing the transit time distribution of an aquifer can be in some cases estimated to a far more accurate degree than with the latter alone. Under the assumption that the aquifer basis is sub-horizontal, the mean transit time of water in the saturated zone can be estimated from spring baseflow recession. This provides an independent estimate of groundwater transit time that can refine those obtained from tritium measurements. The approach is illustrated in a case study predicting atrazine concentration trend in a series of springs draining the fractured-rock aquifer known as the Luxembourg Sandstone. A transport model calibrated on tritium measurements alone predicted different times to trend reversal following the nationwide ban on atrazine in 2005 with different rates of decrease. For some of the springs, the actual time of trend reversal and the rate of change agreed extremely well with the model calibrated using both tritium measurements and the recession of spring discharge during the dry season. The agreement between predicted and observed values was however poorer for the springs displaying the most gentle recessions, possibly indicating a stronger influence of continuous groundwater recharge during the summer months.

Farlin, J.; Maloszewski, P.

2013-05-01

294

A review of component analysis based on magnetization curves: state-of-the art and future developments.  

NASA Astrophysics Data System (ADS)

Rocks and sediments inevitably contain mixtures of magnetic minerals, grain sizes, and weathering states. Most rock magnetic interpretation techniques rely on a set of value parameters, such as susceptibility and isothermal/anhysteretic remanent magnetization (ARM or IRM). These parameters are usually interpreted in terms of mineralogy and domain state of the magnetic particles. In some cases, such interpretation of natural samples can be misleading or inconclusive. A less constrained approach to magnetic mineralogy models is based on the analysis of magnetization curves, which are decomposed into a set of elementary contributions. Each contribution is called a magnetic component, and characterizes a specific set of magnetic grains with a unimodal distribution of physical and chemical properties. Magnetic components are related to specific biogeochemical signatures rather than representing traditional categories, such as SD magnetite. This unconventional approach gives a direct link to the interpretation of natural processes on a multidisciplinary level. Despite the aforementioned advantages, component analysis is not yet come into wide use for three reasons: 1) the lack of quantitative magnetic models for natural, non-ideal magnetic grains and/or the statistical distribution of their properties, 2) the intrinsic mathematical complexity of unmixing problems, and 3) the need of accurate measurements that are beyond the usual standards. Since magnetic components rarely occur alone in natural samples, unmixing techniques and rock magnetic models are interdependent. A big effort has been recently undertaken to verify the basic properties of magnetization curves and obtain useful and reliable solutions of the unmixing problem. The result of this experience is a collection of a few hundred magnetic components identified in various natural environments. The properties of these components are controlled by their biogeochemical history, regardless of the provenance of the hosting sediment. For example, the coercivity of all detrital magnetites is tuned by the transport mechanism (air/water), and the ARM of biogenic magnetites is controlled by the (paleo)redox conditions of the sediment. The consistency of these results supports the linear additivity principle upon which all current magnetic unmixing methods are based. Once the rock magnetic properties of individual components and their statistical distribution is known, the solution of unmixing problems provides important benefits including a great simplification which makes it accessible to non-specialized users. Simplified unmixing algorithms are robust and deliver reliable results based on relatively fast measurements. Two key examples will be presented. In the first example, the magnetic composition of lake sediments is used to develop a model that describes the nonlinear response of a lake to environmental changes. The response function can be used to deconvolute magnetic measurements for paleoclimatology reconstructions. The second example deals with an application of component analysis to obtain a low-cost and fast assessment of the air quality in urban areas. A community effort in setting up a database of magnetic components occurring in the most varied environments will provide us with a new, powerful tool for rock- paleo- and environmental magnetism research.

Egli, R.

2005-05-01

295

Superroot, a recessive mutation in Arabidopsis, confers auxin overproduction.  

PubMed Central

We have isolated seven allelic recessive Arabidopsis mutants, designated superroot (sur1-1 to sur1-7), displaying several abnormalities reminiscent of auxin effects. These characteristics include small and epinastic cotyledons, an elongated hypocotyl in which the connection between the stele and cortical and epidermal cells disintegrates, the development of excess adventitious and lateral roots, a reduced number of leaves, and the absence of an inflorescence. When germinated in the dark, sur1 mutants did not develop the apical hook characteristic of etiolated seedlings. We were able to phenocopy the Sur1- phenotype by supplying auxin to wild-type seedlings, to propagate sur1 explants on phytohormone-deficient medium, and to regenerate shoots from these explants by the addition of cytokinins alone to the culture medium. Analysis by gas chromatography coupled to mass spectrometry indicated increased levels of both free and conjugated indole-3-acetic acid. sur1 was crossed to the mutant axr2 and the altered-auxin response mutant ctr1. The phenotype of both double mutants was additive. The sur1 gene was mapped on chromosome 2 at 0.5 centimorgans from the gene encoding phytochrome B. PMID:8589625

Boerjan, W; Cervera, M T; Delarue, M; Beeckman, T; Dewitte, W; Bellini, C; Caboche, M; Van Onckelen, H; Van Montagu, M; Inzé, D

1995-01-01

296

Linkage of autosomal recessive lamellar ichthyosis to chromosome 14q  

SciTech Connect

The authors have mapped the locus for lamellar ichthyosis (LI), an autosomal recessive skin disease characterized by abnormal cornification of the epidermis. Analysis using both inbred and outbred families manifesting severe LI showed complete linkage to several markers within a 9.3-cM region on chromosome 14q11. Affected individuals in inbred families were also found to have striking homozygosity for markers in this region. Linkage-based genetic counseling and prenatal diagnosis is now available for informative at-risk families. Several transcribed genes have been mapped to the chromosome 14 region containing the LI gene. The transglutaminase 1 gene (TGM1), which encodes one of the enzymes responsible for cross-linking epidermal proteins during formation of the stratum corneum, maps to this interval. The TGM1 locus was completely linked to LI (Z = 9.11), suggesting that TGM1 is a good candidate for further investigation of this disorder. The genes for four serine proteases also map to this region but are expressed only in hematopoietic or mast cells, making them less likely candidates.

Russell, L.J.; Compton, J.G.; Bale, S.J. [National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, MD (United States); DiGiovanna, J.J. [National Cancer Institute, Bethesda, MD (United States); Hashem, N. [Ains-Shams Univ. Medical Genetics Center, Cairo (Egypt)

1994-12-01

297

Oxidative Recession, Sulfur Release, and Al203 Spallation for Y-Doped Alloys  

NASA Technical Reports Server (NTRS)

Second-order spallation phenomena have been noted for Y-doped Rene'N5 after long term oxidation at 1150 degrees C. The reason for this behavior has not been conclusively identified. A mass equivalence analysis has shown that the surface recession resulting from oxidation has the potential of releasing about 0.15 monolayer of sulfur for every 1 mg/sq cm of oxygen reacted for an alloy containing 5 ppmw of sulfur. This amount is significant in comparison to levels that have been shown to result in first-order spallation behavior for undoped alloys. Oxidative recession is therefore speculated to be a contributing source of sulfur and second-order spallation for Y-doped alloys.

Smialek, James L.

2001-01-01

298

Curved Space or Curved Vacuum?  

E-print Network

While the simple picture of a spatially flat, matter plus cosmological constant universe fits current observation of the accelerated expansion, strong consideration has also been given to models with dynamical vacuum energy. We examine the tradeoff of ``curving'' the vacuum but retaining spatial flatness, vs. curving space but retaining the cosmological constant. These different breakdowns in the simple picture could readily be distinguished by combined high accuracy supernovae and cosmic microwave background distance measurements. If we allow the uneasy situation of both breakdowns, the curvature can still be measured to 1%, but at the price of degrading estimation of the equation of state time variation by 60% or more, unless additional information (such as weak lensing data or a tight matter density prior) is included.

Eric V. Linder

2005-08-15

299

Removing Shape-Preserving Transformations in Square-Root Elastic (SRE) Framework for Shape Analysis of Curves  

PubMed Central

This paper illustrates and extends an efficient framework, called the square-root-elastic (SRE) framework, for studying shapes of closed curves, that was first introduced in [2]. This framework combines the strengths of two important ideas - elastic shape metric and path-straightening methods - for finding geodesics in shape spaces of curves. The elastic metric allows for optimal matching of features between curves while path-straightening ensures that the algorithm results in geodesic paths. This paper extends this framework by removing two important shape preserving transformations: rotations and re-parameterizations, by forming quotient spaces and constructing geodesics on these quotient spaces. These ideas are demonstrated using experiments involving 2D and 3D curves. PMID:21738385

Joshi, Shantanu H.; Klassen, Eric; Srivastava, Anuj; Jermyn, Ian

2011-01-01

300

Timing of Holocene Glacier Recessions in the Swiss Alps  

NASA Astrophysics Data System (ADS)

Alpine glaciers are sensitive climate indicators on time scales as short as decades to centuries. Periods of cold and wet climatic conditions cause glacial advances and deposition of moraines. Subsequent change to warmer and drier conditions cause glacial recessions. Since the cold event of the Little Ice Age glaciers in the Swiss Alps have retreated substantially exposing high walls of lateral moraines which consist of a stack of overlying till units. Previous work focused on such stacked moraines and the related glacial advances. However, such paleoclimatic reconstructions based only on moraines are incomplete, in particular for periods of glacial recession. This study examines Holocene glacier recessions based on pieces of wood and peat occurring in glaciofluvial deposits of outburst flood events. These subfossil remains indicate that (i) glaciers were once smaller than present, (ii) climate conditions allowed vegetation growth and a higher treeline elevation than today, (iii) sequences of glaciofluvial gravels and lodgement tills accumulated in now glaciated basins. We focus in this study on three climaticly different re-gions: i.e. Unteraar Glacier (Central Alps), Tschierva Glacier (Eastern Alps) and Ried Glacier (South Central Alps). The conventional radiocarbon and AMS dating was used to determine the age of more than 140 samples of wood and peat fragments. The results show that glacier recessions occurred in distinct phases throughout the Holocene, synchronously in different Alpine regions. The total duration of recession phases is longer than 5500 yr or > 50 % of the Holocene epoch. The glacial recessions are separated by glacial advances, which occurred in time periods shorter than 400 yr. A comparison of our Holocene record of glacier length variations with the ice rafted debris events in the North Atlantic, the Be-10 record of ice cores and atmospheric ? 14C suggest a combination of solar and North Atlantic forcing. Thus, situations of glacial recession, to the extent of smaller glaciers than present, occurred throughout the Holocene.

Joerin, U. E.; Stocker, T. F.; Schluechter, C.

2004-12-01

301

Multivariate curve resolution of pH gradient flow injection mixture analysis with correction of the Schlieren effect.  

PubMed

Multivariate curve resolution using alternating least squares (MCR-ALS) was used to quantify ascorbic (AA) and acetylsalicylic (ASA) acids in four pharmaceutical samples using a flow injection analysis (FIA) system with pH gradient and a diode array (DAD) spectrometer as a detector. Four different pharmaceutical drugs were analyzed, giving a data array of dimensions 51 x 291 x 61, corresponding respectively to number of samples, FIA times and spectral wavelengths. MCR-ALS was applied to these large data sets using different constraints to have optimal resolution and optimal quantitative estimations of the two analytes (AA and ASA). Since both analytes give an acid-basic pair of species contributing to the UV recorded signal, at least four components sholuld be proposed to model AA and ASA in synthetic mixture samples. Moreover, one additional component was needed to resolve accurately the Schlieren effect and another additional component was also needed to model the presence of possible interferences (like caffeine) in the commercial drugs tablets, giving therefore a total number of 6 independent components needed. The best quantification relative errors were around 2% compared to the reference values obtained by HPLC and by the oxidation-reduction titrimetric method, for ASA and AA respectively. In this work, the application of MCR-ALS allowed for the first time the full resolution of the FIA diffusion profile due to the Schlieren effect as an independent signal contribution, suggesting that the proposed MCR-ALS method allows for its accurate correction in FIA-DAD systems. PMID:18493679

Carneiro, Renato L; Braga, Jez Willian B; Poppi, Ronei J; Tauler, Romà

2008-06-01

302

High-resolution DNA melt-curve analysis for cost-effective mass screening of pairwise species interactions.  

PubMed

Ecological studies of pairwise interactions are constrained by the methods available for rapid species identification of the interacting organisms. The resolution of data required to characterize species interaction networks at multiple spatio-temporal scales can be intensive, and therefore laborious and costly to collect. We explore the utility of high-resolution DNA melt-curve analysis (HRM) as a rapid species identification method. An approach was developed to identify organisms at the pairwise interaction level, with particular application to cryptic species interactions that are traditionally difficult to study. Here, we selected a challenging application; to identify the presence/absence of pathogenic fungi (Sporothrix inflata, Ophiostoma nigrocarpum and Ophiostoma galeiforme) transported by bark beetle vectors (Hylastes ater and Hylurgus ligniperda). The technique was able to distinguish between different species of DNA within a single, pooled sample. In test applications, HRM was effective in the mass screening and identification of pathogenic fungal species carried by many individual bark beetle vectors (n = 455 beetles screened) across large geographic scales. For two of the fungal species, there was no difference in the frequency of association with either of their vectors, but for the third fungal species there was a shift in vector-pathogen associations across locations. This technique allows rapid, mass screening and characterization of species interactions at a fraction of the time and cost of traditional methods. It is anticipated that this method can be readily applied to explore other cryptic species interactions, or other studies requiring rapid generation of large data sets and/or high-throughput efficiency. PMID:23875939

McCarthy, James K; Didham, Raphael K; Brockerhoff, Eckehard G; van Bysterveldt, Katherine A; Varsani, Arvind

2013-09-01

303

Analysis of nucleotide distribution in the genome of Streptomyces coelicolor A3(2) using the Z curve method.  

PubMed

The nucleotide distribution of all 33,527 open reading frames (ORFs) (> or =300 bp) in the genome of Streptomyces coelicolor A3(2) has been analyzed using the Z curve method. Each ORF is mapped onto a point in a 9-dimensional space. To visualize the distribution of mapping points, the points are projected onto the principal plane based on principal component analysis. Consequently, the distribution pattern of the 33,527 points in the principal plane shows a flower-like shape, in which there are seven distinct regions. In addition to the central region, there are six petal-like regions around the center, one of which corresponds to 7172 coding sequences. The central region and the remaining five petal-like regions correspond to the intergenic sequences and out-of-frame non-coding ORFs, respectively. It is shown that selective pressure produces a remarkable bias of the G+C content among three codon positions, resulting in the interesting phenomenon observed. A similar phenomenon is also observed for other bacterial genomes with high genomic G+C content, such as Pseudomonas aeruginosa PA01 (G+C = 66.6%). However, for the genomes of Bacillus subtilis (G+C = 43.5%) and Clostridium perfringens (G+C = 28.6%), no similar phenomenon was observed. The finding presented here may be useful to improve the gene-finding algorithms for genomes with high G+C content. A set of supplementary materials including the plots displaying the base distribution patterns of ORFs in 12 prokaryotes is provided on the website http://tubic.tju.edu.cn/highGC/. PMID:12681506

Ou, Hong-Yu; Guo, Feng-Biao; Zhang, Chun-Ting

2003-04-10

304

Analysis of tipping-curve measurements performed at the DSS-13 beam-waveguide antenna at 32.0 and 8.45 GigaHertz  

NASA Technical Reports Server (NTRS)

This article reports on the analysis of the Ka-band Antenna Performance Experiment tipping-curve data acquired at the DSS-13 research and development beam-waveguide (BWG) antenna. By measuring the operating system temperatures as the antenna is moved form zenith to low-elevation angles and fitting a model to the data, one can obtain information on how well the overall temperature model behaves at zenith and approximate the contribution due to the atmosphere. The atmospheric contribution estimated from the data can be expressed in the form of (1) atmospheric noise temperatures that can provide weather statistic information and be compared against those estimated from other methods and (2) the atmospheric loss factor used to refer efficiency measurements to zero atmosphere. This article reports on an analysis performed on a set of 68 8.4-GHz and 67 32-GHz tipping-curve data sets acquired between December 1993 and May 1995 and compares the results with those inferred from a surface model using input meteorological data and from water vapor radiometer (WVR) data. The general results are that, for a selected subset of tip curves, (1) the BWG tipping-curve atmospheric temperatures are in good agreement with those determined from WVR data (the average difference is 0.06 +/- 0.64 K at 32 GHz) and (2) the surface model average values are biased 3.6 K below those of the BWG and WVR at 32 GHz.

Morabito, D. D.; Skjerve, L.

1995-01-01

305

Inference and analysis of xenon outflow curves under multi-pulse injection in two-dimensional chromatography.  

PubMed

Multidimensional gas chromatography is widely applied to atmospheric xenon monitoring for the Comprehensive Nuclear-Test-Ban Treaty (CTBT). To improve the capability for xenon sampling from the atmosphere, sampling techniques have been investigated in detail. The sampling techniques are designed by xenon outflow curves which are influenced by many factors, and the injecting condition is one of the key factors that could influence the xenon outflow curves. In this paper, the xenon outflow curves of single-pulse injection in two-dimensional gas chromatography has been tested and fitted as a function of exponential modified Gaussian distribution. An inference formula of the xenon outflow curve for six-pulse injection is derived, and the inference formula is also tested to compare with its fitting formula of the xenon outflow curve. As a result, the curves of both the one-pulse and six-pulse injections obey the exponential modified Gaussian distribution when the temperature of the activated carbon column's temperature is 26°C and the flow rate of the carrier gas is 35.6mLmin(-1). The retention time of the xenon peak for one-pulse injection is 215min, and the peak width is 138min. For the six-pulse injection, however, the retention time is delayed to 255min, and the peak width broadens to 222min. According to the inferred formula of the xenon outflow curve for the six-pulse injection, the inferred retention time is 243min, the relative deviation of the retention time is 4.7%, and the inferred peak width is 225min, with a relative deviation of 1.3%. PMID:24007686

Shu-Jiang, Liu; Zhan-Ying, Chen; Yin-Zhong, Chang; Shi-Lian, Wang; Qi, Li; Yuan-Qing, Fan

2013-10-11

306

Rapid Detection of Isoniazid Resistance in Mycobacterium tuberculosis Isolates by Use of Real-Time-PCR-Based Melting Curve Analysis  

PubMed Central

The MeltPro TB/INH assay, recently approved by the Chinese Food and Drug Administration, is a closed-tube, dual-color, melting curve analysis-based, real-time PCR test specially designed to detect 30 isoniazid (INH) resistance mutations in katG position 315 (katG 315), the inhA promoter (positions ?17 to ?8), inhA position 94, and the ahpC promoter (positions ?44 to ?30 and ?15 to 3) of Mycobacterium tuberculosis. Here we evaluated both the analytical performance and clinical performance of this assay. Analytical studies with corresponding panels demonstrated that the accuracy for detection of different mutation types (10 wild-type samples and 12 mutant type samples), the limit of detection (2 × 103 to 2 × 104 bacilli/ml), reproducibility (standard deviation [SD], <0.4°C), and the lowest heteroresistance level (40%) all met the parameters preset by the kit. The assay could be run on five types of real-time PCR machines, with the shortest running time (105 min) obtained with the LightCycler 480 II. Clinical studies enrolled 1,096 clinical isolates collected from three geographically different tuberculosis centers, including 437 INH-resistant isolates and 659 INH-susceptible isolates characterized by traditional drug susceptibility testing on Löwenstein-Jensen solid medium. The clinical sensitivity and specificity of the MeltPro TB/INH assay were 90.8% and 96.4%, respectively. DNA sequencing analysis showed that, except for the 5 mutants outside the detection range of the MeltPro assay, a concordance rate between the two methods of 99.1% (457/461) was obtained. Among the 26 mutation types detected, katG S315T (AGC?ACC), inhA ?15C?T, katG S315N (AGC?AAC), and ahpC promoter ?10C?T accounted for more than 90%. Overall, the MeltPro TB/INH assay represents a reliable and rapid tool for the detection of INH resistance in clinical isolates. PMID:24599986

Hu, Siyu; Li, Guoli; Li, Hui; Liu, Xiaoli; Niu, Jianjun; Quan, Shengmao; Wang, Feng; Wen, Huixin

2014-01-01

307

Identification of CHIP as a Novel Causative Gene for Autosomal Recessive Cerebellar Ataxia  

PubMed Central

Autosomal recessive cerebellar ataxias are a group of neurodegenerative disorders that are characterized by complex clinical and genetic heterogeneity. Although more than 20 disease-causing genes have been identified, many patients are still currently without a molecular diagnosis. In a two-generation autosomal recessive cerebellar ataxia family, we mapped a linkage to a minimal candidate region on chromosome 16p13.3 flanked by single-nucleotide polymorphism markers rs11248850 and rs1218762. By combining the defined linkage region with the whole-exome sequencing results, we identified a homozygous mutation (c.493CT) in CHIP (NM_005861) in this family. Using Sanger sequencing, we also identified two compound heterozygous mutations (c.389AT/c.441GT; c.621C>G/c.707GC) in CHIP gene in two additional kindreds. These mutations co-segregated exactly with the disease in these families and were not observed in 500 control subjects with matched ancestry. CHIP colocalized with NR2A, a subunit of the N-methyl-D-aspartate receptor, in the cerebellum, pons, medulla oblongata, hippocampus and cerebral cortex. Wild-type, but not disease-associated mutant CHIPs promoted the degradation of NR2A, which may underlie the pathogenesis of ataxia. In conclusion, using a combination of whole-exome sequencing and linkage analysis, we identified CHIP, encoding a U-box containing ubiquitin E3 ligase, as a novel causative gene for autosomal recessive cerebellar ataxia. PMID:24312598

Shi, Yuting; Wang, Junling; Li, Jia-Da; Ren, Haigang; Guan, Wenjuan; He, Miao; Yan, Weiqian; Zhou, Ying; Hu, Zhengmao; Zhang, Jianguo; Xiao, Jingjing; Su, Zheng; Dai, Meizhi; Wang, Jun; Jiang, Hong; Guo, Jifeng; Zhou, Yafang; Zhang, Fufeng; Li, Nan; Du, Juan; Xu, Qian; Hu, Yacen; Pan, Qian; Shen, Lu; Wang, Guanghui; Xia, Kun; Zhang, Zhuohua; Tang, Beisha

2013-01-01

308

AIPL1 implicated in the pathogenesis of two cases of autosomal recessive retinal degeneration  

PubMed Central

Purpose To localize and identify the gene and mutations causing autosomal recessive retinal dystrophy in two consanguineous Pakistani families. Methods Consanguineous families from Pakistan were ascertained to be affected with autosomal recessive retinal degeneration. All affected individuals underwent thorough ophthalmologic examinations. Blood samples were collected, and genomic DNA was extracted using a salting out procedure. Genotyping was performed using microsatellite markers spaced at approximately 10 cM intervals. Two-point linkage analysis was performed with the lod score method. Direct DNA sequencing of amplified genomic DNA was performed for mutation screening of candidate genes. Results Genome-wide linkage scans yielded a lod score of 3.05 at ?=0 for D17S1832 and 3.82 at ?=0 for D17S938, localizing the disease gene to a 12.22 cM (6.64 Mb) region flanked by D17S1828 and D17S1852 for family 61032 and family 61227, which contains aryl hydrocarbon receptor interacting protein-like 1 (AIPL1), a gene previously implicated in recessive Leber congenital amaurosis and autosomal dominant cone-rod dystrophy. Sequencing of AIPL1 showed a homozygous c.773G>C (p.Arg258Pro) sequence change in all affected individuals of family 61032 and a homozygous c.465G>T (p.(H93_Q155del)) change in all affected members of family 61227. Conclusions The results strongly suggest that the c.773G>C (p.R258P) and c.465G>T (p.(H93_Q155del)) mutations in AIPL1 cause autosomal recessive retinal degeneration in these consanguineous Pakistani families. PMID:24426771

Li, David; Jin, Chongfei; Jiao, Xiaodong; Li, Lin; Bushra, Tahmina; Naeem, Muhammad Asif; Butt, Nadeem H.; Husnain, Tayyab; Sieving, Paul A.; Riazuddin, Sheikh; Riazuddin, S. Amer

2014-01-01

309

Multilayer theory for delamination analysis of a composite curved bar subjected to end forces and end moments  

NASA Technical Reports Server (NTRS)

A composite test specimen in the shape of a semicircular curved bar subjected to bending offers an excellent stress field for studying the open-mode delamination behavior of laminated composite materials. This is because the open-mode delamination nucleates at the midspan of the curved bar. The classical anisotropic elasticity theory was used to construct a multilayer theory for the calculations of the stress and deformation fields induced in the multilayered composite semicircular curved bar subjected to end forces and end moments. The radial location and intensity of the open-mode delamination stress were calculated and were compared with the results obtained from the anisotropic continuum theory and from the finite element method. The multilayer theory gave more accurate predictions of the location and the intensity of the open-mode delamination stress than those calculated from the anisotropic continuum theory.

Ko, William L.; Jackson, Raymond H.

1989-01-01

310

BVRcIc Light Curve Analysis of the Shallow Contact Extreme Mass Ratio W UMa Binary, HR Boo  

NASA Astrophysics Data System (ADS)

HR Boo [? (2000) = 14h 48m 33.015s, ? (2000) = +21° 44 ?01.09"] is an NSVS variable first observed in 1999 and listed in the 79th name list (Kazarovets, 2008). It was identified as a W UMa variable and first characterized by the period 0.27289 d. This was later corrected to 0.31587 d. Various observers have reported ~20 timings of minimum light over the past ~4000 orbital epochs. Our 2012 curve is of high precision, with probable errors averaging 5 mmag. The curves have shallow amplitudes, averaging 0.4 magnitudes, yet apparently exhibit total eclipses. J-K observations yield a G6V type for the system. A linear period determination of 0.31596785(7) d was computed with the available timings of minimum light. When the NSVS light curve is considered in the period study, it indicates that the period has been clearly decreasing over the past 15,000 orbits. The quadratic term from this period study is statistically significant at 5 ?. This indicates that the binary is evidently undergoing magnetic breaking due to enhanced magnetic solar activity.The light curve solution reveals that HR Boo is a shallow contact system with a Roche-lobe fill-out of ~4% and a mass ratio of q= 0.25. This is exceedingly rare, since extreme mass ratio binaries usually have high fill-outs. In addition, an unusually dark 13 degree radius cool spot with a T-factor of ~50% was computed near the L1 Point of the primary component. A 32 minute duration of constant light is seen in the secondary eclipse indicating the occurrence of a total eclipse. This was confirmed in the light curve solution. Although the secondary component has a slightly higher temperature than the primary component, some 30 K, the light curves have the appearance of an A-type W UMa system. The system may have come into contact recently.

Faulkner, Danny R.; Samec, Ronald G.; Shebs, Travis; Benkendorf, Barry

2014-06-01

311

The Great Recession and the Risk for Child Maltreatment  

PubMed Central

This study draws on the Fragile Families and Child Wellbeing Study (N = 2,032), a birth cohort study of families with children from 20 U.S. cities. Interviews occurred between August 2007, and February 2010, when the children were approximately 9 years old. Macro-economic indicators of the Great Recession such as the Consumer Sentiment Index and unemployment and home foreclosure rates were matched to the data to estimate the links between different measures of the Great Recession and high frequency maternal spanking. We find that the large decline in consumer confidence during the Great Recession, as measured by the Consumer Sentiment Index, was associated with worse parenting behavior. In particular, lower levels of consumer confidence were associated with increased levels of high frequency spanking, a parenting behavior that is associated with greater likelihood of being contacted by child protective services. PMID:24045057

Brooks-Gunn, Jeanne; Schneider, William; Waldfogel, Jane

2013-01-01

312

On the correctness of methods for the determination of the darkening coefficient from atmospheric models and the analysis of the light curves of classical eclipsing systems  

NASA Astrophysics Data System (ADS)

It is shown that the determination of darkening coefficients from atmosphere models must be made under the condition of conservation of the full radiative flux when replacing the model intensity distribution by the linear law. An analysis of series of new methods of darkening coefficient determination was made from the solution of classical eclipsing systems' light curves. It was concluded that darkening coefficient determination by Lavrov's method for total and annular eclipses leads to the best result.

Rubashevskii, A. A.

313

Economic recession and fertility in the developed world.  

PubMed

This article reviews research on the effects of economic recessions on fertility in the developed world. We study how economic downturns, as measured by various indicators, especially by declining GDP levels, falling consumer confidence, and rising unemployment, were found to affect fertility. We also discuss particular mechanisms through which the recession may have influenced fertility behavior, including the effects of economic uncertainty, falling income, changes in the housing market, and rising enrollment in higher education, and also factors that influence fertility indirectly such as declining marriage rates. Most studies find that fertility tends to be pro-cyclical and often rises and declines with the ups and downs of the business cycle. Usually, these aggregate effects are relatively small (typically, a few percentage points) and of short durations; in addition they often influence especially the timing of childbearing and in most cases do not leave an imprint on cohort fertility levels. Therefore, major long-term fertility shifts often continue seemingly uninterrupted during the recession—including the fertility declines before and during the Great Depression of the 1930s and before and during the oil shock crises of the 1970s. Changes in the opportunity costs of childbearing and fertility behavior during economic downturn vary by sex, age, social status, and number of children; childless young adults are usually most affected. Furthermore, various policies and institutions may modify or even reverse the relationship between recessions and fertility. The first evidence pertaining to the recent recession falls in line with these findings. In most countries, the recession has brought a decline in the number of births and fertility rates, often marking a sharp halt to the previous decade of rising fertility rates. PMID:22066128

Sobotka, Tomáš; Skirbekk, Vegard; Philipov, Dimiter

2011-01-01

314

Detection of Ehrlichia canis in canine blood samples by real-time fluorescence resonance energy transfer (FRET) PCR and melting curve analysis.  

PubMed

Ehrlichia canis is a small pleomorphic gram-negative, coccoid, obligatory intracellular bacterium and the cause of canine monocytic ehrlichiosis. A real-time fluorescence resonance energy transfer polymerase chain reaction (real-time FRET PCR) coupled with melting curve analysis was established for detection of E. canis infection in canine blood samples. The VirB9 gene was amplified using one pair of primers and the melting curve analysis was generated by heating the hybridizing probes and amplified products. Eight E. canis-infected dog blood samples were initially identified using the Giemsa staining/microscopic method followed by conventional PCR (cPCR)/Sanger sequencing for confirmation. The sensitivity and specificity of the real-time FRET PCR detection were 87.5% and 100%, respectively and the limit of detection was 6.6 x 10(3) copies of positive E. canis control plasmids. The real-time FRET PCR with melting curve analysis reported here is better than microscopic visualization or cPCR because the method is not affected by the false bias inherent in the microscopic method. Furthermore, many samples can be processed rapidly at the same time. This convenient tool is beneficial as an alternative assay for the epidemiologic study of canine ehrlichiosis as well as for eradication of these organisms in prevention and control programs in endemic areas. PMID:25507246

Kongklieng, Amornmas; Thanchomnang, Tongjit; Intapan, Pewpan M; Boonmars, Thidarut; Janwan, Penchom; Sanpool, Oranuch; Lulitanond, Viraphong; Taweethavonsawat, Piyanan; Chungpivat, Sudchit; Morakote, Nimit; Maleewong, Wanchai

2014-09-01

315

Detection of Ehrlichia canis in canine blood samples by real-time fluorescence resonance energy transfer (FRET) PCR and melting curve analysis.  

PubMed

Ehrlichia canis is a small pleomorphic gram-negative, coccoid, obligatory intracellular bacterium and the cause of canine monocytic ehrlichiosis. A real-time fluorescence resonance energy transfer polymerase chain reaction (real-time FRET PCR) coupled with melting curve analysis was established for detection of E. canis infection in canine blood samples. The VirB9 gene was amplified using one pair of primers and the melting curve analysis was generated by heating the hybridizing probes and amplified products. Eight E. canis-infected dog blood samples were initially identified using the Giemsa staining/microscopic method followed by conventional PCR (cPCR)/Sanger sequencing for confirmation. The sensitivity and specificity of the real-time FRET PCR detection were 87.5% and 100%, respectively and the limit of detection was 6.6 x 10(3) copies of positive E. canis control plasmids. The real-time FRET PCR with melting curve analysis reported here is better than microscopic visualization or cPCR because the method is not affected by the false bias inherent in the microscopic method. Furthermore, many samples can be processed rapidly at the same time. This convenient tool is beneficial as an alternative assay for the epidemiologic study of canine ehrlichiosis as well as for eradication of these organisms in prevention and control programs in endemic areas. PMID:25417518

Kongklieng, Amornmas; Thanchomnang, Tongjit; Intapan, Pewpan M; Boonmars, Thidarut; Janwan, Penchom; Sanpool, Oranuch; Lulitanond, Viraphong; Taweethavonsawat, Piyanan; Chungpivat, Sudchit; Morakote, Nimit; Maleewong, Wanchai

2014-09-01

316

The autosomal recessively inherited progressive myoclonus epilepsies and their genes.  

PubMed

Autosomal recessively inherited progressive myoclonus epilepsies (PMEs) include Lafora disease, Unverricht-Lundborg disease, the neuronal ceroid lipofuscinoses, type I sialidosis (cherry-red spot myoclonus), action myoclonus-renal failure syndrome, and type III Gaucher disease. Almost all the autosomal recessively inherited PMEs are lysosomal diseases, with the exception of Lafora disease in which neither the accumulating material nor the gene products are in lysosomes. Progress in identifying the causative defects of PME is near-complete. Much work lies ahead to resolve the pathobiology and neurophysiology of this group of devastating disorders. PMID:19469843

Ramachandran, Nivetha; Girard, Jean-Marie; Turnbull, Julie; Minassian, Berge A

2009-05-01

317

Computational Analysis of Flow in a Curved Tube Model of the Coronary Arteries: Effects of Time-varying Curvature  

Microsoft Academic Search

The flow through a curved tube whose radius of curvature varies with time was studied in order to better understand flow patterns in coronary arteries. A computational flow model was constructed using commercially available software. The artery model featured a uniform circular cross section, and the curvature was assumed to be constant along the tube, and in one plane. The

Aland Santamarina; Erlend Weydahl

1998-01-01

318

Statistical methods for pavement performance curve building, historical analysis, data sampling and storage: Appendix D. Final report  

SciTech Connect

The technical memorandum is intended to discuss the detailed procedure required for carrying out the statistical analyses of historical pavement condition data for building pavement performance curves. This chapter assumes the availability of the historical data in a spreadsheet format (Microsoft{trademark} Excel) that has been retrieved from the master (pavement management system) database.

NONE

1998-08-01

319

A Unified Latent Curve, Latent State-Trait Analysis of the Developmental Trajectories and Correlates of Positive Orientation  

ERIC Educational Resources Information Center

Literature documents that the judgments people hold about themselves, their life, and their future are important ingredients of their psychological functioning and well-being and are commonly related to each other. In this article, results from a longitudinal study (N = 298, 45% males) are presented. Using an integrative Latent Curve, Latent…

Alessandri, Guido; Caprara, Gian Vittorio; Tisak, John

2012-01-01

320

A numerical analysis of heat and fluid flow with a deformable curved free surface in a laser melting process  

Microsoft Academic Search

In this study, a numerical investigation was performed to examine the effects of curved surface shapes, laser power intensity, and the thermophysical properties of a material such as Reynolds and Capillary numbers on the shape, size, and surface topography of the melt pool. This investigation was completed via two-dimensional axisymmetric thermocapillary convection analyses during laser melting processes with deformable free

Young-Deuk Kim; Woo-Seung Kim

2008-01-01

321

A Unified Latent Curve, Latent State-Trait Analysis of the Developmental Trajectories and Correlates of Positive Orientation  

Microsoft Academic Search

Literature documents that the judgments people hold about themselves, their life, and their future are important ingredients of their psychological functioning and well-being and are commonly related to each other. In this article, results from a longitudinal study (N = 298, 45% males) are presented. Using an integrative Latent Curve, Latent State-Trait Model (Tisak & Tisak, 2000), results corroborated (a)

Guido Alessandri; Gian Vittorio Caprara; John Tisak

2012-01-01

322

Rational Curves 598 CHAPTER 22. RATIONAL CURVES  

E-print Network

Chapter 22 Rational Curves 597 #12;598 CHAPTER 22. RATIONAL CURVES 22.1 Rational Curves and Multiprojective Maps In this chapter, rational curves are investigated. After a quick review of the traditional parametric definition in terms of homogeneous polynomials, we explore the possibility of defining rational

Gallier, Jean

323

Quantitative analysis of electrophoresis data: novel curve fitting methodology and its application to the determination of a protein-DNA binding constant.  

PubMed Central

A computer program, GelExplorer, which uses a new methodology for obtaining quantitative information about electrophoresis has been developed. It provides a straightforward, easy-to-use graphical interface, and includes a number of features which offer significant advantages over existing methods for quantitative gel analysis. The method uses curve fitting with a nonlinear least-squares optimization to deconvolute overlapping bands. Unlike most curve fitting approaches, the data is treated in two dimensions, fitting all the data across the entire width of the lane. This allows for accurate determination of the intensities of individual, overlapping bands, and in particular allows imperfectly shaped bands to be accurately modeled. Experiments described in this paper demonstrate empirically that the Lorentzian lineshape reproduces the contours of an individual gel band and provides a better model than the Gaussian function for curve fitting of electrophoresis bands. Results from several fitting applications are presented and a discussion of the sources and magnitudes of uncertainties in the results is included. Finally, the method is applied to the quantitative analysis of a hydroxyl radical footprint titration experiment to obtain the free energy of binding of the lambda repressor protein to the OR1 operator DNA sequence. PMID:9016637

Shadle, S E; Allen, D F; Guo, H; Pogozelski, W K; Bashkin, J S; Tullius, T D

1997-01-01

324

Lateral sphenoid sinus recess cerebrospinal fluid leak: a case series.  

PubMed

The lateral recess of the sphenoid sinus is one of the most common sites of meningocele and spontaneous cerebrospinal fluid (CSF) leak. Despite the availability of several techniques for closure of skull base defects occurring in this location, recurrence still poses a major challenge. This report reviews the experience of surgical repair of lateral sphenoid sinus recess CSF leak at a tertiary referral center and provides a brief discussion of this rare lesion. Nine surgeries were performed for six cases of spontaneous lateral sphenoid sinus recess CSF leak (two revisions and one repair of a new defect). Two patients presented with intracranial hypertension (ICH) and four with meningocele or meningoencephalocele. The transpterygoid approach was used in two procedures. A multilayer graft was used in seven cases and a nasoseptal flap in two. Three patients received lumbar or ventricular shunts, and one received acetazolamide for ICH management. Two minor complications were recorded, and the overall surgical success rate was 78 %. We conclude that nasoseptal flaps are a valid option for repair of recurrent CSF leaks, particularly in the lateral sphenoid sinus recess. Furthermore, identification and correction of ICH plays an essential role in the success of treatment in this patient population. PMID:24748381

Melo, Nelson Almeida d'Ávila; Borges, Bruno Barros Pinto; Magliarelli Filho, Pedro Augusto; Godoy, Maria Dantas Costa Lima; Pereira, Larissa Vilela; Pinna, Fabio de Rezende; Voegels, Richard Louis

2014-09-01

325

CLOSE UP OF THE RECESSED MAIN ENTRY OF THE UNIT ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

CLOSE UP OF THE RECESSED MAIN ENTRY OF THE UNIT - Camp H.M. Smith and Navy Public Works Center Manana Title VII (Capehart) Housing, U-Shaped Two-Bedroom Single-Family Type 6, Birch Circle, Elm Drive, Elm Circle, and Date Drive, Pearl City, Honolulu County, HI

326

DINING ROOM. NOTE THE RECESSED PULLS ON THE SLIDING DOORS. ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

DINING ROOM. NOTE THE RECESSED PULLS ON THE SLIDING DOORS. VIEW FACING EAST - Camp H.M. Smith and Navy Public Works Center Manana Title VII (Capehart) Housing, U-Shaped Two-Bedroom Single-Family Type 6, Birch Circle, Elm Drive, Elm Circle, and Date Drive, Pearl City, Honolulu County, HI

327

Spectrum of ABCR gene mutations in autosomal recessive macular dystrophies  

Microsoft Academic Search

Stargardt disease (STGD) and late-onset fundus flavimaculatus (FFM) are autosomal recessive conditions leading to macular degenerations in childhood and adulthood, respectively. Recently, mutations of the photoreceptor cell-specific ATP binding transporter gene (ABCR) have been reported in Stargardt disease. Here, we report on the screening of the whole coding sequence of the ABCR gene in 40 unrelated STGD and 15 FFM

Jean-Michel Rozet; Sylvie Gerber; Eric Souied; Isabelle Perrault; Sophie Châtelin; Imad Ghazi; Corinne Leowski; Jean-Louis Dufier; Arnold Munnich; Josseline Kaplan; J-M Rozet

1998-01-01

328

Pseudoxanthoma Elasticum Is a Recessive Disease Characterized by Compound Heterozygosity  

Microsoft Academic Search

Pseudoxanthoma elasticum (PXE) is caused by mutations in the ABCC6 gene. Historically, PXE has been suggested to be inherited either in an autosomal dominant or autosomal recessive manner. To determine the exact mode of inheritance of PXE and to address the question of phenotypic expression in mutation carriers, we identified seven pedigrees with affected individuals in two different generations and

Franziska Ringpfeil; Kelly McGuigan; Lauren Fuchsel; Heidi Kozic; Margarita Larralde; Mark Lebwohl; Jouni Uitto

2006-01-01

329

Mountain Monitor Tracking Economic Recession and Recovery in  

E-print Network

Mountain Monitor Tracking Economic Recession and Recovery in the Intermountain West's Metropolitan metropolitan areas of the Mountain region were undergoing some of both the strongest and weakest economic graphics across each indicator at www.brookings.edu/metromonitor . #12;MOUNTAIN MONITOR: 2ND QUARTER 2012 2

Hemmers, Oliver

330

Mountain Monitor Tracking Economic Recession and Recovery in  

E-print Network

Mountain Monitor Tracking Economic Recession and Recovery in the Intermountain West's Metropolitan of the Mountain West in the first quarter of 2013. Multiple metro areas achieved long-awaited full employment throughout the region. Despite progress on multiple fronts, though, many Mountain metro areas remain scarred

Hemmers, Oliver

331

Mountain Monitor Tracking Economic Recession and Recovery in  

E-print Network

Mountain Monitor Tracking Economic Recession and Recovery in the Intermountain West's Metropolitan Areas Kenan Fikri and Mark Muro December 2013 The quarter's Mountain Monitor marks the four-year anniversary of Brookings Mountain West's quarterly tracking of the uneven pace of recovery across the major

Hemmers, Oliver

332

Mountain Monitor Tracking Economic Recession and Recovery in  

E-print Network

Mountain Monitor Tracking Economic Recession and Recovery in the Intermountain West's Metropolitan graphics across each indicator at www.brookings.edu/metromonitor . #12;MOUNTAIN MONITOR: 3RD QUARTER 2012 2 the quarter with a familiar cloud of uncertainty hanging over it about the contours of the emerging Mountain

Hemmers, Oliver

333

Mountain Monitor Tracking Economic Recession and Recovery in  

E-print Network

Mountain Monitor Tracking Economic Recession and Recovery in : Las Vegas December 2010 Due://globalmetrosummit.net), the usual Mountain Monitor will not appear this quarter but will return in its full depth and entirety in March 2011. In its place, and to commemorate the one-year anniversary of the Mountain Monitor, gress

Hemmers, Oliver

334

13. DETAIL VIEW, OF TAINTER GATE PIER, SHOWING RECESSES FOR ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

13. DETAIL VIEW, OF TAINTER GATE PIER, SHOWING RECESSES FOR EMERGENCY BULKHEADS AND DOGGING DEVICES, LOOKING SOUTHEAST (DOWN FACE). UPSTREAM FACE OF TAINTER GATE IS VISIBLE IN UPPER RIGHT CORNER - Upper Mississippi River 9-Foot Channel Project, Lock & Dam 26R, Alton, Madison County, IL

335

Problems on the Playground: A Different Approach to Recess  

ERIC Educational Resources Information Center

Today's school administrators and counselors recognize the continuing problem of aggression at recess, but struggle with how to respond to it. Given the wide range of possibilities, what can schools do to improve the playground environment? This article addresses that question and also offers a specific disciplinary model that can be applied to…

Levine, James E.

2012-01-01

336

Exterior building details of Building A; east façade: recessed panel ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Exterior building details of Building A; east façade: recessed panel inscribed "1859", historic window opening with concrete sill above door, cement plaster dentil course and cornice, truncated wood beam ends, plaster finished brick wall, granite base; westerly view - San Quentin State Prison, Building 22, Point San Quentin, San Quentin, Marin County, CA

337

Tag, Catch, and Other Unnatural Acts at Recess (Circa 2014)  

ERIC Educational Resources Information Center

This commentary details a news event in which Carrie Weber Middle School in Port Washington, NY, supposedly banned students from using balls, playing tag, and doing cartwheels during recess. Public reaction in the form of news items, tweets, blogs, and commentary is sampled, and news releases from the Weber Middle School that were barely covered…

Sydnor, Synthia

2014-01-01

338

Results of Singular Neurectomy in the Posterior Ampullary Recess  

Microsoft Academic Search

Objective: To determine the effect on hearing and balance symptoms following singular neurectomy (SN) for benign paroxysmal positional vertigo (BPPV) in the ampullary recess of the posterior semicircular canal. Research Design: The charts of 242 patients with chronic disabling BPPV who were treated with SN over a 29-year period (1972–2001) were reviewed. The results on relief of BPPV and hearing

Richard R. Gacek; Mark R. Gacek

2002-01-01

339

Applications to One Business School Skyrocketed Despite Recession  

ERIC Educational Resources Information Center

In the past two years, the global financial crisis has wreaked havoc on businesses in America and abroad. But the gloom and doom seems to have had the opposite effect on business schools. The reason is that a recession often signals the perfect time for proactive students to sharpen their skill sets, shift their career goals (whether toward a…

Tao, Sharon

2010-01-01

340

Employment of Ex-Offenders during the Recession  

ERIC Educational Resources Information Center

Researchers have rarely examined post-release employment among offenders during a period of economic recession. However, studies on employment issues among post-release offenders have showed that released offenders would likely have a higher unemployment rate due to their inadequate education and job skills (Batiuk, 1997; Harlow, 2003; Vacca,…

Nally, John M.; Lockwood, Susan R.; Ho, Taiping

2011-01-01

341

3. EXTERIOR OF FRONT ENTRY SHOWING GABLE OVER RECESSED PORCH ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

3. EXTERIOR OF FRONT ENTRY SHOWING GABLE OVER RECESSED PORCH WITH RUSTIC STYLE DECORATIVE TREATMENT. WELDED STEEL PORCH RAILING ADDED IN 1972 IS VISIBLE AT PHOTO CENTER. VIEW TO SOUTHWEST. - Rush Creek Hydroelectric System, Worker Cottage, Rush Creek, June Lake, Mono County, CA

342

The Post-Recession Employment Situation: A Comparative Perspective  

ERIC Educational Resources Information Center

Slow economic growth since the end of the U.S. recession in June of 2009 has not yet translated into increases in employment large enough to meaningfully reduce the rate of unemployment. Because expansionary macroeconomic policy has been pursued on both the fiscal and monetary fronts, it appears at first glance that the hands of government at this…

Couch, Kenneth A.

2012-01-01

343

Recession Amnesia and the Prospects for New England's Institutions  

ERIC Educational Resources Information Center

Among the little truly predictable, the author suggests three truths. First is the inevitability of recessions. Second is the belief that, in prosperity, these good times will just keep on rolling. Third is the fall. Bubbles will burst, myths shatter, plans unravel and pain sadly borne unjustly by those who didn't have a hand in the decisions that…

Halfond, Jay A.

2010-01-01

344

Glacier recession and hydrologic change in the tropics  

E-print Network

as a buffer during the tropical dry sea- son and drought years, accelerating glacial recession and its impacts by the Intergovernmental Panel on Cli- mate Change (Raupach et al 2007) and that abrupt and irreversible impacts from with potentially grave consequences for the people of the region (Bradley et al 2006). Human vulnerability

Howat, Ian M.

345

Children Most Impacted by the Economic Recession Prepared by the  

E-print Network

will hold. -- President-elect Barack Obama, January 8, 2009 The United States was formally declared to be in an economic recession in late 2008, but the effects of child poverty were seen far earlier in Milwaukee Public levels of income by neighborhood for employed parents and analyzes levels of child poverty among schools

Saldin, Dilano

346

Analysis of the Effect of Light and Temperature on the Fluence Response Curves for Germination of Rumex obtusifolius  

PubMed Central

Both red light (10 minutes) and 35°C treatment (60 minutes) stimulate the germination of seeds of Rumex obtusifolius otherwise maintained in darkness at 25°C. Fluence response curves were determined for the effect of red light to stimulate germination of seeds with and without 35°C treatment. The endogenous far-red absorbing form (Pfr) level in the seeds was determined using short saturating fluences of wavelengths of light which maintain different proportions of phytochrome as Pfr at equilibrium. In the seed batches investigated, the endogenous Pfr level was found to be 4% or less of the total phytochrome. High dark germination after 35°C treatment does not result from an increase in sensitivity of the whole population to Pfr. Calculated fluence response curves for germination which best fit the experimental data suggest that seeds germinate in darkness after 35°C treatment because of a nonphytochrome-related process (overriding factor). PMID:16664125

Takaki, Massanori; Heeringa, Gerda H.; Cone, John W.; Kendrick, Richard E.

1985-01-01

347

Analysis of the Effect of Light and Temperature on the Fluence Response Curves for Germination of Rumex obtusifolius.  

PubMed

Both red light (10 minutes) and 35 degrees C treatment (60 minutes) stimulate the germination of seeds of Rumex obtusifolius otherwise maintained in darkness at 25 degrees C. Fluence response curves were determined for the effect of red light to stimulate germination of seeds with and without 35 degrees C treatment. The endogenous far-red absorbing form (Pfr) level in the seeds was determined using short saturating fluences of wavelengths of light which maintain different proportions of phytochrome as Pfr at equilibrium. In the seed batches investigated, the endogenous Pfr level was found to be 4% or less of the total phytochrome. High dark germination after 35 degrees C treatment does not result from an increase in sensitivity of the whole population to Pfr. Calculated fluence response curves for germination which best fit the experimental data suggest that seeds germinate in darkness after 35 degrees C treatment because of a nonphytochrome-related process (overriding factor). PMID:16664125

Takaki, M; Heeringa, G H; Cone, J W; Kendrick, R E

1985-03-01

348

Analysis of MOST light curves of five young stars in Taurus-Auriga and Lupus~3 Star Forming Regions  

E-print Network

Continuous photometric observations of five young stars obtained by the MOST satellite in 2009 and 2010 in the Taurus and Lupus star formation regions are presented. Using light curve modelling under the assumption of internal invariability of spots, we obtained small values of the solar-type differential-rotation parameter (k=0.0005-0.009) for three spotted weak-line T Tau stars, V410 Tau, V987 Tau and Lupus 3-14; for another spotted WTTS, Lupus 3-48, the data are consistent with a rigidly rotating surface (k=0). Three flares of similar rise (4 min 30 sec) and decay (1 h 45 min) times were detected in the light curve of Lupus 3-14. The brightness of the classical T Tau star RY Tau continuously decreased over 3 weeks of its observations with a variable modulation not showing any obvious periodic signal.

Siwak, Michal; Matthews, Jaymie M; Kuschnig, Rainer; Guenther, David B; Moffat, Anthony F J; Sasselov, Dimitar; Weiss, Werner W

2011-01-01

349

Human Capital, Social Support, and Economic Well-being among Rural, Low-income Mothers: A Latent Growth Curve Analysis  

Microsoft Academic Search

The purpose of this study was to better understand human capital and social support in the long-term economic well-being of\\u000a rural, low-income mothers in the US. Three waves of data from a multi-state, longitudinal investigation tracking the well-being\\u000a of rural families, known as “Rural Families Speak,” were used to test two latent growth curve models of economic well-being.\\u000a Results indicated

Leigh Ann Simmons; Bonnie Braun; David W. Wright; Scott R. Miller

2007-01-01

350

Flow Curve Determination at Large Plastic Strain Levels: Limitations of the Membrane Theory in the Analysis of the Hydraulic Bulge Test  

NASA Astrophysics Data System (ADS)

Nowadays, an accurate determination of the true stress-strain curve is a key-element for all finite element (FE) forming predictions. Since the introduction of Advanced High Strength Steels (AHSS) for the automotive market, the standard uniaxial tension test suffers the drawback of relatively low uniform elongations. The extrapolation of the uniaxial stress-strain curve up to large strains is not without consequence in forming predictions—especially formability and springback. One of the means to solve this problem is to use experimental tests where large plastic strain levels can be reached. The hydraulic bulge test is one of these tests. The effective plastic strain levels reached in the bulge test are of about 0.7. From an experimental standpoint, the biaxial flow stress is estimated using measurement of fluid pressure, and calculation of thickness and curvature at the pole, via appropriate measurements and assumptions. The biaxial stress at the pole is determined using the membrane equilibrium equation. The analysis proposed in this paper consists of performing "virtual experiments" where the results obtained by means of FE calculations are used as input data for determining the biaxial stress-strain law in agreement with the experimental procedure. In this way, a critical discussion of the experimental procedure can be made, by comparing the "experimental" stress-strain curve (Membrane theory curve) with the "reference" one introduced in the simulations. In particular, the influences of the "(die diameter)/thickness" ratio and of the plastic anisotropy are studied, and limitations of the hydraulic bulge test analysis are discussed.

Lemoine, X.; Iancu, A.; Ferron, G.

2011-05-01

351

Maternal uniparental isodisomy of chromosome 14: association with autosomal recessive rod monochromacy.  

PubMed Central

Rod monochromacy (complete congenital achromatopsia) is inherited as an autosomal recessive trait of unknown genetic location. The disorder is characterized by total absence of color discrimination because retinal cone photoreceptors do not develop; systemic features do not occur. A 20-year-old white female with rod monochromacy presented with short stature (less than 5th percentile), mild developmental delay, premature puberty, small hands and feet (length less than 5th percentile), minimal dysmorphism, and a reproductive history of three consecutive first-trimester miscarriages. Cytogenetic analysis showed 45,XX,rob(14;14) in all 30 cells examined. Southern analysis of DNA from the patient and her phenotypically normal mother and two brothers (her father is deceased) ascertained the parental origin of the 14;14 Robertsonian translocation. Analysis of RFLPs associated with nine VNTR probes and two dinucleotide repeat polymorphisms from chromosome 14 demonstrated that the patient had inherited two copies of a single allele, each of which was maternally derived. A fully informative RFLP analysis of three probes from chromosome 14 enabled reconstruction of the paternal haplotype and showed the lack of any paternal contribution to the subject. These data are consistent with maternal isodisomy for all portions of chromosome 14 tested by these markers. This finding suggests that rod monochromacy maps to chromosome 14, and it emphasizes the importance of uniparental isodisomy to provide a putative chromosomal assignment of a gene for a rare autosomal recessive disorder. Images Figure 1 Figure 3 Figure 4 Figure 5 PMID:1347967

Pentao, L; Lewis, R A; Ledbetter, D H; Patel, P I; Lupski, J R

1992-01-01

352

Detection of a Knockdown Resistance Mutation Associated with Permethrin Resistance in the Body Louse Pediculus humanus corporis by Use of Melting Curve Analysis Genotyping  

PubMed Central

Louse-borne diseases are prevalent in the homeless, and body louse eradication has thus far been unsuccessful in this population. We aim to develop a rapid and robust genotyping method usable in large field-based clinical studies to monitor permethrin resistance in the human body louse Pediculus humanus corporis. We assessed a melting curve analysis genotyping method based on real-time PCR using hybridization probes to detect the M815I-T917I-L920F knockdown resistance (kdr) mutation in the paraorthologous voltage-sensitive sodium channel (VSSC) ? subunit gene, which is associated with permethrin resistance. The 908-bp DNA fragment of the VSSC gene, encoding the ? subunit of the sodium channel and encompassing the three mutation sites, was PCR sequenced from 65 lice collected from a homeless population. We noted a high prevalence of the 3 indicated mutations in the body lice collected from homeless people (100% for the M815I and L920F mutations and 56.73% for the T917I mutation). These results were confirmed by melting curve analysis genotyping, which had a calculated sensitivity of 100% for the M815I and T917I mutations and of 98% for the L920F mutation. The specificity was 100% for M815I and L920F and 96% for T917I. Melting curve analysis genotyping is a fast, sensitive, and specific tool that is fully compatible with the analysis of a large number of samples in epidemiological surveys, allowing the simultaneous genotyping of 96 samples in just over an hour (75 min). Thus, it is perfectly suited for the epidemiological monitoring of permethrin resistance in human body lice in large-scale clinical studies. PMID:22573588

Drali, Rezak; Benkouiten, Samir; Badiaga, Sékéné; Bitam, Idir

2012-01-01

353

JiTT - Fighting Recession: 2009  

NSDL National Science Digital Library

This is a JiTT exercise in which students apply introductory-level macroeconomic analysis to the question of how large the stimulus package put forward to Congress in early 2009 needed to be to close the recessionary gap facing the U.S. economy at that time. In particular, this exercise asks students to bring together the concepts of potential and actual GDP, recessionary gaps, fiscal policy, spending and taxing multipliers, and effects of changes in aggregate spending on employment and output.

Scott Simkins

354

Direct Analysis of JV-Curves Applied to an Outdoor-Degrading CdTe Module (Presentation)  

SciTech Connect

We present the application of a phenomenological four parameter equation to fit and analyze regularly measured current density-voltage JV curves of a CdTe module during 2.5 years of outdoor operation. The parameters are physically meaningful, i.e. the short circuit current density Jsc, open circuit voltage Voc and differential resistances Rsc, and Roc. For the chosen module, the fill factor FF degradation overweighs the degradation of Jsc and Voc. Interestingly, with outdoor exposure, not only the conductance at short circuit, Gsc, increases but also the Gsc(Jsc)-dependence. This is well explained with an increase in voltage dependent charge carrier collection in CdTe.

Jordan, D; Kurtz, S.; Ulbrich, C.; Gerber, A.; Rau, U.

2014-03-01

355

Investigation on non-exchange spring behaviour and exchange spring behaviour: A first order reversal curve analysis  

NASA Astrophysics Data System (ADS)

The First Order Reversal Curve (FORC) method has been utilised to understand the magnetization reversal and the extent of the irreversible magnetization of the soft CoFe2O4-hard SrFe12O19 nanocomposite in the nonexchange spring and the exchange spring regime. The single peak switching behaviour in the FORC distribution of the exchange spring composite confirms the coherent reversal of the soft and hard phases. The onset of the nucleation field and the magnetization reversal by domain wall movement are also evident from the FORC measurements.

Roy, Debangsu; Sreenivasulu, K. V.; Anil Kumar, P. S.

2013-11-01

356

Elementary School Recess: Selected Readings, Games, and Activities for Teachers and Parents.  

ERIC Educational Resources Information Center

Based upon the principle that all children have a right to play and to experience the benefits of recess, this book assists elementary school teachers and parents in offering children in preschool through Grade 6 appropriate recess games and activities and provides a variety of readings that support the need for recess activities. The book is…

Clements, Rhonda L., Ed.

357

Did Cuts in State Aid during the Great Recession Lead to Changes in Local Property Taxes?  

ERIC Educational Resources Information Center

The Great Recession led to marked declines in state revenue. In this paper we investigate whether (and how) local school districts modified their funding and taxing decisions in response to state aid declines in the post-recession period. Our results reveal school districts responded to state aid cuts in the post-recession period by countering…

Chakrabarti, Rajashri; Livingston, Max; Roy, Joydeep

2014-01-01

358

Climatic and basin factors affecting the flood frequency curve: PART I - A simple sensitivity analysis based on the continuous simulation approach  

NASA Astrophysics Data System (ADS)

Regionalized and at-site flood frequency curves exhibit considerable variability in their shapes, but the factors controlling the variability (other than sampling effects) are not well understood. An application of the Monte Carlo simulation-based derived distribution approach is presented in this two-part paper to explore the influence of climate, described by simulated rainfall and evapotranspiration time series, and basin factors on the flood frequency curve (ffc). The sensitivity analysis conducted in the paper should not be interpreted as reflecting possible climate changes, but the results can provide an indication of the changes to which the flood frequency curve might be sensitive. A single site Neyman Scott point process model of rainfall, with convective and stratiform cells (Cowpertwait, 1994; 1995), has been employed to generate synthetic rainfall inputs to a rainfall runoff model. The time series of the potential evapotranspiration (ETp) demand has been represented through an AR(n) model with seasonal component, while a simplified version of the ARNO rainfall-runoff model (Todini, 1996) has been employed to simulate the continuous discharge time series. All these models have been parameterised in a realistic manner using observed data and results from previous applications, to obtain ‘reference’ parameter sets for a synthetic case study. Subsequently, perturbations to the model parameters have been made one-at-a-time and the sensitivities of the generated annual maximum rainfall and flood frequency curves (unstandardised, and standardised by the mean) have been assessed. Overall, the sensitivity analysis described in this paper suggests that the soil moisture regime, and, in particular, the probability distribution of soil moisture content at the storm arrival time, can be considered as a unifying link between the perturbations to the several parameters and their effects on the standardised and unstandardised ffcs, thus revealing the physical mechanism through which their influence is exercised. However, perturbations to the parameters of the linear routing component affect only the unstandardised ffc. In Franchini et al. (2000), the sensitivity analysis of the model parameters has been assessed through an analysis of variance (ANOVA) of the results obtained from a formal experimental design, where all the parameters are allowed to vary simultaneously, thus providing deeper insight into the interactions between the different factors. This approach allows a wider range of climatic and basin conditions to be analysed and reinforces the results presented in this paper, which provide valuable new insight into the climatic and basin factors controlling the ffc.

Hashemi, A. M.; Franchini, M.; O'Connell, P. E.

359

Estimation of the initial velocity of enzyme-catalysed reactions by non-linear regression analysis of progress curves.  

PubMed Central

Most methods for studying the kinetic properties of an enzyme involve the determination of initial velocities. When the reaction progress curve shows significant curvature due to depletion of the substrate, accumulation of inhibitory products or instability of the enzyme, estimation of the initial velocity is a subjective and inexact process. Two methods have been suggested [Cornish-Bowden (1975) Biochem. J. 144, 305-312; Boeker (1982) Biochem J. 203, 117-123] that attempt to eliminate this subjective element. The present study offers a third alternative, which is based on fitting a reparameterized form of the integrated Michaelis-Menten equation to the progress curves by non-linear regression. This method yields estimates and standard errors of the initial velocity and of the time to reach 50% reaction. No prior knowledge of the apparent product concentration at zero time or infinite time is required, since both of these quantities are also estimated from the data. It is shown that this method yields reliable estimates of the initial velocity under a wide range of circumstances, including those where the two previously published methods perform poorly. PMID:4004816

Duggleby, R G

1985-01-01

360

Radiation Hydrodynamics of SN 1987A. I. Global Analysis of the Light Curve for the First 4 Months  

NASA Astrophysics Data System (ADS)

The optical/UV light curves of SN 1987A are analyzed with the multienergy group radiation hydrodynamics code STELLA. The calculated monochromatic and bolometric light curves are compared with observations shortly after shock breakout, during the early plateau, through the broad second maximum, and during the earliest phase of the radioactive tail. We have concentrated on a progenitor model calculated by Nomoto & Hashimoto and Saio, Nomoto, & Kato, which assumes that 14 Msolar of the stellar mass is ejected. Using this model, we have updated constraints on the explosion energy and the extent of mixing in the ejecta. In particular, we determine the most likely range of E/M (explosion energy over ejecta mass) and R0 (radius of the progenitor). In general, our best models have energies in the range E=(1.1+/-0.3)x1051 ergs, and the agreement is better than in earlier, flux-limited diffusion calculations for the same explosion energy. Our modeled B and V fluxes compare well with observations, while the flux in U undershoots after ~10 days by a factor of a few, presumably owing to NLTE and line transfer effects. We also compare our results with IUE observations, and a very good quantitative agreement is found for the first days, and for one IUE band (2500-3000 Å) as long as for 3 months. We point out that the V flux estimated by McNaught & Zoltowski should probably be revised to a lower value.

Blinnikov, Sergei; Lundqvist, Peter; Bartunov, Oleg; Nomoto, Ken'ichi; Iwamoto, Koichi

2000-04-01

361

Mutations of ESPN cause autosomal recessive deafness and vestibular dysfunction  

PubMed Central

We mapped a human deafness locus DFNB36 to chromosome 1p36.3 in two consanguineous families segregating recessively inherited deafness and vestibular areflexia. This phenotype co-segregates with either of two frameshift mutations, 1988delAGAG and 2469delGTCA, in ESPN, which encodes a calcium-insensitive actin-bundling protein called espin. A recessive mutation of ESPN is known to cause hearing loss and vestibular dysfunction in the jerker mouse. Our results establish espin as an essential protein for hearing and vestibular function in humans. The abnormal vestibular phenotype associated with ESPN mutations will be a useful clinical marker for refining the differential diagnosis of non-syndromic deafness. PMID:15286153

Naz, S; Griffith, A; Riazuddin, S; Hampton, L; Battey, J; Khan, S; Riazuddin, S; Wilcox, E; Friedman, T

2004-01-01

362

Pseudoxanthoma elasticum is a recessive disease characterized by compound heterozygosity.  

PubMed

Pseudoxanthoma elasticum (PXE) is caused by mutations in the ABCC6 gene. Historically, PXE has been suggested to be inherited either in an autosomal dominant or autosomal recessive manner. To determine the exact mode of inheritance of PXE and to address the question of phenotypic expression in mutation carriers, we identified seven pedigrees with affected individuals in two different generations and sequenced the entire coding region of ABCC6 in affected individuals, presumed carriers with a limited phenotype and unaffected family members. Two allelic mutations were identified in each individual with unambiguous diagnosis of PXE, as well as in those with only minimal clinical signs suggestive of PXE but with positive skin biopsy. Missense mutations were frequently detected in the latter cases. In conclusion, PXE is inherited in an autosomal recessive manner and presence of disease in two generations is due to pseudodominance. PMID:16410789

Ringpfeil, Franziska; McGuigan, Kelly; Fuchsel, Lauren; Kozic, Heidi; Larralde, Margarita; Lebwohl, Mark; Uitto, Jouni

2006-04-01

363

Effective Motivation during Recessions in the IT Client Services Industry  

E-print Network

to Y2K. Since the effects in the IT industry are felt second hand, the industry started taking cost cutting measures by generally reducing their staffs. Recessions or downturns in the economy are difficult for everyone because they are full... method to determine the factors that create job satisfaction and motivate. The results of hygiene factors and motivators from the IT industry within ABC Company are listed below. Hygine Factors Dedication and loyalty to employer Enjoyment of Work...

Wootton, Paul

2005-12-16

364

A probably distinct autosomal recessive thoraco-limb dysplasia.  

PubMed Central

A Mexican mestizo family is reported in which two opposite sexed sibs, born to consanguineous parents, had a skeletal dysplasia. The salient features were a bell shaped thorax owing to short ribs, short limbed dwarfism, pelvic hypoplasia, dislocatable radial heads, elongated distal fibulae, and improvement with age. It is concluded that the present observation probably represents a distinct autosomal recessive thoraco-limb dysplasia identifiable at birth. Images PMID:3184141

Rivera, H; Perez-Salas, J M; Nazara, Z; Ramirez, M L

1988-01-01

365

Martian North Polar Cap Recession: 2000 Mars Orbiter Camera Observations  

Microsoft Academic Search

The wide-angle cameras of the Mars Orbiter Camera (MOC) on the Mars Global Surveyor have recorded the 2000 recession of the seasonal CO2 cap in the north polar region from LS=330° to 90°. In stark contrast to the asymmetric behavior of the south seasonal cap, the seasonal north cap remains relatively circular and uniform until mid-spring when the retreat reaches

Philip B James; Bruce A Cantor

2001-01-01

366

Operating temperatures of recessed fluorescent fixtures with thermal insulation  

SciTech Connect

Tests were performed to determine steady state surface temperatures for recessed fluorescent fixtures operated with and without thermal insulation on the top side of the fixture and to identify potential problems associated with the installation of thermal insulation. In addition to measuring temperatures, means were sought by which the fixtures can be thermally insulated and operated without fire hazards or damage to the fixture. (MCW)

Yarbrough, D.W.; Toor, I.A.

1981-05-01

367

Composite curved frames for helicopter fuselage structure  

NASA Technical Reports Server (NTRS)

This paper presents the results of analysis and testing of composite curved frames. A major frame was selected from the UH-60 Black Hawk helicopter and designed as a composite structure. The curved beam effects were expected to increase flange axial stresses and induce transverse bending. A NASTRAN finite element analysis was conducted and the results were used in the design of composite curved frame specimens. Three specimens were fabricated and five static tests were conducted. The NASTRAN analysis and test results are compared for axial, transverse, and Web strains. Results show the curved beam effects are closely predicted by a NASTRAN analysis and the effects increase with loading on the composite frames.

Rich, M. J.; Lowry, D. W.

1984-01-01

368

Autosomal recessive disorders among Arabs: an overview from Kuwait.  

PubMed Central

Kuwait has a cosmopolitan population of 1.7 million, mostly Arabs. This population is a mosaic of large and small minorities representing most Arab communities. In general, Kuwait's population is characterized by a rapid rate of growth, large family size, high rates of consanguineous marriages within the Arab communities with low frequency of intermarriage between them, and the presence of genetic isolates and semi-isolates in some extended families and Bedouin tribes. Genetic services have been available in Kuwait for over a decade. During this time it has become clear that Arabs have a high frequency of genetic disorders, and in particular autosomal recessive traits. Their pattern is unique and some disorders are relatively common. Examples are Bardet-Biedl and Meckel syndromes, phenylketonuria, and familial Mediterranean fever. A relatively large number of new syndromes and variants have been delineated in Kuwait's population, many being the result of homozygosity for autosomal recessive genes that occurred because of inbreeding. Some of these syndromes have subsequently been found in other parts of the world, negating the concept of the private syndrome. This paper provides an overview of autosomal recessive disorders among the Arabs in Kuwait from a personal perspective and published studies, and highlights the need for genetic services in Arab countries with the goal of prevention and treatment of genetic disorders. PMID:8014972

Teebi, A S

1994-01-01

369

Isolated Curves for Hyperelliptic Curve Cryptography  

E-print Network

We introduce the notion of isolated genus two curves. As there is no known efficient algorithm to explicitly construct isogenies between two genus two curves with large conductor gap, the discrete log problem (DLP) cannot be efficiently carried over from an isolated curve to a large set of isogenous curves. Thus isolated genus two curves might be more secure for DLP based hyperelliptic curve cryptography. We establish results on explicit expressions for the index of an endomorphism ring in the maximal CM order, and give conditions under which the index is a prime number or an almost prime number for three different categories of quartic CM fields. We also derived heuristic asymptotic results on the densities and distributions of isolated genus two curves with CM by any fixed quartic CM field. Computational results, which are also shown for three explicit examples, agree with heuristic prediction with errors within a tolerable range.

Wang, Wenhan

2012-01-01

370

Analysis of progress curves for a highly concentrated Michaelian enzyme in the presence or absence of product inhibition.  

PubMed Central

Methods are given for analysing the time course of an enzyme-catalysed reaction when the concentration of the enzyme itself is high, a situation which is often found in vivo. (1) The integrated form of the kinetic equation for a concentrated Michaelian enzyme in absence of product inhibition is given. Parameters are shown to be calculated easily using non-linear fitting procedures. (2) A general algorithm to analyse progress-curve data in more complex cases (i.e. when the analytical form of the integrated rate equation is not known or is exceedingly complex) is proposed. This algorithm may be used for any enzyme mechanism for which the differential form of the kinetic equation may be written analytically. We show that the method allows differentiation between the main types of product inhibition which may occur in the case of a highly concentrated Michaelian enzyme. PMID:4062893

Kellershohn, N; Laurent, M

1985-01-01

371

Mutations induced in Tradescantia by small doses of X-rays and neutrons - Analysis of dose-response curves.  

NASA Technical Reports Server (NTRS)

Dose-response curves for pink somatic mutations in Tradescantia stamen hairs were analyzed after neutron and X-ray irradiation with doses ranging from a fraction of a rad to the region of saturation. The dose-effect relation for neutrons indicates a linear dependence from 0.01 to 8 rads; between 0.25 and 5 rads, a linear dependence is indicated for X-rays also. As a consequence the relative biological effectiveness reaches a constant value (about 50) at low doses. The observations are in good agreement with the predictions of the theory of dual radiation action and support its interpretation of the effects of radiation on higher organisms. The doubling dose of X-rays was found to be nearly 1 rad.

Sparrow, A. H.; Underbrink, A. G.; Rossi, H. H.

1972-01-01

372

Analysis of the long-term behavior of solute transport with nonlinear equilibrium sorption using breakthrough curves and temporal moments  

NASA Astrophysics Data System (ADS)

We analyzed the long-term behavior of breakthrough curves (BTCs) and temporal moments of a solute subjected to Freundlich equilibrium sorption ( s= kcn). For one-dimensional transport in a homogeneous porous medium, we derived a power-law relation between travel time, ?, and solute displacement, x¯, with the exponent being equal to the Freundlich n exponent. The mean solute velocity, derived from the first time moment, was found to change as ?n-1 . For n values larger than 0.66, the second time moment could be related to cx¯2/ n, where c is a constant. An approach based on the use of a critical concentration was developed to estimate the presence of the asymptotic regime in the tail of the BTC. This approach was tested successfully using numerical case studies. One-dimensional numerical simulations with varying values of k, n and initial mass were run to verify the closed form analytical expressions for the large time behavior of temporal moments and the tailing part of breakthrough curves. Good agreement between the slope of the tailing part of log-log transformed BTCs and the predicted slope using asymptotic theory was found. Asymptotic theory in general underestimated the magnitude of the concentration in the tail. The quality of the estimated concentrations in the tail improved for small values of the dispersivity. Experimental BTCs of uranin and benazolin were analyzed in combination with sorption/desorption batch experiments using asymptotic theory. A good agreement between the value of n parameter derived from desorption experiment with benazolin and the value of the n parameter derived from the tail of the BTC was found.

Vereecken, H.; Jaekel, U.; Schwarze, H.

2002-06-01

373

Analysis of the long-term behavior of solute transport with nonlinear equilibrium sorption using breakthrough curves and temporal moments.  

PubMed

We analyzed the long-term behavior of breakthrough curves (BTCs) and temporal moments of a solute subjected to Freundlich equilibrium sorption (s = kc(n)). For one-dimensional transport in a homogeneous porous medium, we derived a power-law relation between travel time, tau, and solute displacement, chi, with the exponent being equal to the Freundlich n exponent. The mean solute velocity, derived from the first time moment, was found to change as tau(n-1). For n values larger than 0.66, the second time moment could be related to c chi(2/n), where c is a constant. An approach based on the use of a critical concentration was developed to estimate the presence of the asymptotic regime in the tail of the BTC. This approach was tested successfully using numerical case studies. One-dimensional numerical simulations with varying values of k, n and initial mass were run to verify the closed form analytical expressions for the large time behavior of temporal moments and the tailing part of breakthrough curves. Good agreement between the slope of the tailing part of log-log transformed BTCs and the predicted slope using asymptotic theory was found. Asymptotic theory in general underestimated the magnitude of the concentration in the tail. The quality of the estimated concentrations in the tail improved for small values of the dispersivity. Experimental BTCs of uranin and benazolin were analyzed in combination with sorption/desorption batch experiments using asymptotic theory. A good agreement between the value of n parameter derived from desorption experiment with benazolin and the value of the n parameter derived from the tail of the BTC was found. PMID:12102322

Vereecken, H; Jaekel, U; Schwarze, H

2002-06-01

374

Mutations in connexin31 underlie recessive as well as dominant non-syndromic hearing loss.  

PubMed

Mutations in the GJB3 gene encoding connexin31 (Cx31) can cause a dominant non-syndromic form of hearing loss (DFNA2). To determine whether mutations at this locus can also cause recessive non-syndromic deafness, we screened 25 Chinese families with recessive deafness and identified in two families affected individuals who were compound heterozygotes for Cx31 mutations. The three affected individuals in the two families were born to non-consanguineous parents and had an early onset bilateral sensorineural hearing loss. In both families, differing SSCP patterns were observed in affected and unaffected individuals. Sequence analysis in both families demonstrated an in-frame 3 bp deletion (423-425delATT) in one allele, which leads to the loss of an isoleucine residue at codon 141, and a 423A-->G transversion in the other allele, which creates an Ile-->Val substitution at codon 141 (I141V). Neither of these two mutations was detected in DNA from 100 unrelated control subjects. The altered isoleucine residue lies within the third conserved alpha-helical transmembrane domain (M3), which is critical for the formation of the wall of the gap junction pore. Both the deletion of the isoleucine residue 141 and its substitution to valine in the two families could alter the structure of M3, and impair the function of the gap junction. The present data demonstrate that, like mutations in connexin26, mutations in Cx31 can lead to both recessive and dominant forms of non-syndromic deafness. PMID:10587579

Liu, X Z; Xia, X J; Xu, L R; Pandya, A; Liang, C Y; Blanton, S H; Brown, S D; Steel, K P; Nance, W E

2000-01-01

375

Comparison of Coronally Advanced and Semilunar Coronally Repositioned Flap for the Treatment of Gingival Recession  

PubMed Central

Background: Gingival Recession (GR) occurs in population with low oral hygiene levels. Root coverage may be achieved by a number of surgical techniques, including pedicle gingival grafts, free grafts, connective tissue grafts, gtr may also be used. The objective of the present study is to compare the clinical outcomes of the Semilunar Coronally Repositioned Flap (SCRF) and Coronally Advanced Flap (CAF) procedure in the treatment of miller’s class I gingival recession defects in maxillary teeth. Materials and Methods: Twenty systemically healthy patients, with isolated miller’s class 1 gingival recessions, were selected and allocated randomly into two groups, Group I and Group II with 10 patients in each. In Group I, the patients were treated with coronally advanced flap procedure with sling sutures, whereas in Group II, patients were treated with semilunar coronally repositioned flap without sutures. Results: Descriptive statistical analysis has been carried out in the present study. Results on continuous measurements are presented on Mean ± SD. Significance is assessed at 5 % level of significance. Student t-test (two tailed, dependent) has been used to find the significance of study parameters between baseline - 3 months and baseline - 6 months, 90% Confidence interval for mean has been computed. Conclusion: CAF provides consistently better results than SCRF With all other parameters, such as clinical attachment levels, percentage of root coverage and complete root coverage and esthetics were taken into account, caf was found to be superior. In contrary to this, there is significant increase in width of keratinized tissue in scrf group. PMID:25121054

Moka, Leela Rani; M, Srinivas; D, Narasimha swamy; Swarna, Chakrapani; Putcha, Madhusudhan

2014-01-01

376

A novel splice site mutation in the EDAR gene underlies autosomal recessive hypohidrotic ectodermal dysplasia in a Pakistani family.  

PubMed

Hypohidrotic ectodermal dysplasia is a rare congenital disorder that results in abnormalities in the structures of ectodermal origin: hair, teeth, and eccrine sweat glands. DNA sequence analysis of EDAR gene in a Pakistani family, demonstrating autosomal recessive form of hypohidrotic ectodermal dysplasia, identified a novel homozygous mutation affecting splice donor site of exon 5 [IVS5+1G > or = C] of the gene. PMID:20199431

Wasif, Naveed; Tariq, Muhammad; Ali, Ghazanfar; Hassan, Muhammad Jawad; Ahmad, Wasim

2010-01-01

377

A New Type Curve Analysis for Shale Gas/Oil Reservoir Production Performance with Dual Porosity Linear System.  

E-print Network

??With increase of interest in exploiting shale gas/oil reservoirs with multiple stage fractured horizontal wells, complexity of production analysis and reservoir description have also increased.… (more)

Abdulal, Haider Jaffar

2012-01-01

378

The application of non-linear curve fitting routines to the analysis of mid-infrared images obtained from single polymeric microparticles.  

PubMed

For the first time, we report a series of time resolved images of a single PLGA microparticle undergoing hydrolysis at 70 °C that have been obtained using attenuated total reflectance-Fourier transform infrared spectroscopic (ATR-FTIR) imaging. A novel partially supervised non-linear curve fitting (NLCF) tool was developed to identify and fit peaks to the infrared spectrum obtained from each pixel within the 64 × 64 array. The output from the NLCF was evaluated by comparison with a traditional peak height (PH) data analysis approach and multivariate curve resolution alternating least squares (MCR-ALS) analysis for the same images, in order to understand the limitations and advantages of the NLCF methodology. The NLCF method was shown to facilitate consistent spatial resolution enhancement as defined using the step-edge approach on dry microparticle images when compared to images derived from both PH measurements and MCR-ALS. The NLCF method was shown to improve both the S/N and sharpness of images obtained during an evolving experiment, providing a better insight into the magnitude of hydration layers and particle dimension changes during hydrolysis. The NLCF approach facilitated the calculation of hydrolysis rate constants for both the glycolic (kG) and lactic (kL) acid segments of the PLGA copolymer. This represents a real advantage over MCR-ALS which could not distinguish between the two segments due to colinearity within the data. The NLCF approach made it possible to calculate the hydrolysis rate constants from a single pixel, unlike the peak height data analysis approach which suffered from poor S/N at each pixel. These findings show the potential value of applying NLCF to the study of real-time chemical processes at the micron scale, assisting in the understanding of the mechanisms of chemical processes that occur within microparticles and enhancing the value of the mid-IR ATR analysis. PMID:24665462

Keles, Hakan; Naylor, Andrew; Clegg, Francis; Sammon, Chris

2014-05-21

379

Analytical solutions for recession analyses of sloping aquifers - applicability on relict rock glaciers in alpine catchments  

NASA Astrophysics Data System (ADS)

Rock glaciers as aquifer systems in alpine catchments may strongly influence the hydrological characteristics of these catchments. Thus, they have a high impact on the ecosystem and potential natural hazards such as for example debris flow. Therefore, knowledge of the hydrodynamic processes, internal structure and properties of these aquifers is important for resource management and risk assessment. The investigation of such aquifers often turns out to be expensive and technically complicated because of their strongly limited accessibility. Analytical solutions of discharge recession provide a quick and easy way to estimate aquifer parameters. However, due to simplifying assumptions the validity of the interpretation is often questionable. In this study we compared results of an analytical solution of discharge recessions with results based on a numerical model. This was done in order to analyse the range of uncertainties and the applicability of the analytical method in alpine catchment areas. The research area is a 0.76 km² large catchment in the Seckauer Tauern Range, Austria. The dominant aquifer in this catchment is a rock glacier, namely the Schöneben Rock Glacier. This relict rock glacier (i.e. containing no permafrost at present) covers an area of 0.11 km² and is drained by one spring at the rock glacier front. The rock glacier consists predominantly of gneissic sediments (mainly coarse-grained, blocky at the surface) and extends from 1720 to 1905 m a.s.l.. Discharge of the rock glacier spring is automatically measured since 2002. Electric conductivity and water temperature is monitored since 2008. An automatic weather station was installed in 2011 in the central part of the catchment. Additionally data of geophysical surveys (refraction seismic and ground penetrating radar) have been used to analyse the base slope and inner structure of the rock glacier. The measured data are incorporated into a numerical model implemented in MODFLOW. The numerical model was then compared to the analytical solution based on the one dimensional Boussinesq equation for unconfined flow in sloping aquifers. Field observations as well as results from the numerical model suggest that the rock glacier has a complex internal structure with zones of low hydraulic conductivity and a high conductive layer on top. The analytical solution attempts to represent this heterogeneous aquifer by an equivalent homogeneous medium. However, as the relative contribution of the different aquifer components varies throughout the recession, the parameter estimates are not easily interpreted in terms of actual aquifer properties. Employing analytical solutions for recession analysis in this type of setting therefore requires a sound understanding of the internal structure and its influence on the flow and storage processes within the rock glacier.

Pauritsch, Marcus; Birk, Steffen; Hergarten, Stefan; Kellerer-Pirklbauer, Andreas; Winkler, Gerfried

2014-05-01

380

Growth Curve Models for the Analysis of Phenotype Arrays for a Systems Biology Overview of Yersinia pestis  

SciTech Connect

The Phenotype MicroArray technology of Biolog, Inc. (Hayward, CA) measures the respiration of cells as a function of time in thousands of microwells simultaneously, and thus provides a high-throughput means of studying cellular phenotypes. The microwells contain compounds involved in a number of biochemical pathways, as well as chemicals that test the sensitivity of cells against antibiotics and stress. While the PM experimental workflow is completely automated, statistical methods to analyze and interpret the data are lagging behind. To take full advantage of the technology, it is essential to develop efficient analytical methods to quantify the information in the complex datasets resulting from PM experiments. We propose the use of statistical growth-curve models to rigorously quantify observed differences in PM experiments, in the context of the growth and metabolism of Yersinia pestis cells grown under different physiological conditions. The information from PM experiments complement genomic and proteomic results and can be used to identify gene function and in drug development. Successful coupling of phenomics results with genomics and proteomics will lead to an unprecedented ability to characterize bacterial function at a systems biology level.

Fodor, I K; Holtz-Morris, A E; McCutchen-Maloney, S L

2005-09-08

381

Comparative Analysis of the Volatile Components of Agrimonia eupatoria from Leaves and Roots by Gas Chromatography-Mass Spectrometry and Multivariate Curve Resolution.  

PubMed

Gas chromatography-mass spectrometry and multivariate curve resolution were applied to the differential analysis of the volatile components in Agrimonia eupatoria specimens from different plant parts. After extracted with water distillation method, the volatile components in Agrimonia eupatoria from leaves and roots were detected by GC-MS. Then the qualitative and quantitative analysis of the volatile components in the main root of Agrimonia eupatoria was completed with the help of subwindow factor analysis resolving two-dimensional original data into mass spectra and chromatograms. 68 of 87 separated constituents in the total ion chromatogram of the volatile components were identified and quantified, accounting for about 87.03% of the total content. Then, the common peaks in leaf were extracted with orthogonal projection resolution method. Among the components determined, there were 52 components coexisting in the studied samples although the relative content of each component showed difference to some extent. The results showed a fair consistency in their GC-MS fingerprint. It was the first time to apply orthogonal projection method to compare different plant parts of Agrimonia eupatoria, and it reduced the burden of qualitative analysis as well as the subjectivity. The obtained results proved the combined approach powerful for the analysis of complex Agrimonia eupatoria samples. The developed method can be used to further study and quality control of Agrimonia eupatoria. PMID:24286016

Feng, Xiao-Liang; He, Yun-Biao; Liang, Yi-Zeng; Wang, Yu-Lin; Huang, Lan-Fang; Xie, Jian-Wei

2013-01-01

382

Comparative Analysis of the Volatile Components of Agrimonia eupatoria from Leaves and Roots by Gas Chromatography-Mass Spectrometry and Multivariate Curve Resolution  

PubMed Central

Gas chromatography-mass spectrometry and multivariate curve resolution were applied to the differential analysis of the volatile components in Agrimonia eupatoria specimens from different plant parts. After extracted with water distillation method, the volatile components in Agrimonia eupatoria from leaves and roots were detected by GC-MS. Then the qualitative and quantitative analysis of the volatile components in the main root of Agrimonia eupatoria was completed with the help of subwindow factor analysis resolving two-dimensional original data into mass spectra and chromatograms. 68 of 87 separated constituents in the total ion chromatogram of the volatile components were identified and quantified, accounting for about 87.03% of the total content. Then, the common peaks in leaf were extracted with orthogonal projection resolution method. Among the components determined, there were 52 components coexisting in the studied samples although the relative content of each component showed difference to some extent. The results showed a fair consistency in their GC-MS fingerprint. It was the first time to apply orthogonal projection method to compare different plant parts of Agrimonia eupatoria, and it reduced the burden of qualitative analysis as well as the subjectivity. The obtained results proved the combined approach powerful for the analysis of complex Agrimonia eupatoria samples. The developed method can be used to further study and quality control of Agrimonia eupatoria. PMID:24286016

Feng, Xiao-Liang; He, Yun-biao; Liang, Yi-Zeng; Wang, Yu-Lin; Huang, Lan-Fang; Xie, Jian-Wei

2013-01-01

383

Autosomal Recessive Dilated Cardiomyopathy due to DOLK Mutations Results from Abnormal Dystroglycan O-Mannosylation  

PubMed Central

Genetic causes for autosomal recessive forms of dilated cardiomyopathy (DCM) are only rarely identified, although they are thought to contribute considerably to sudden cardiac death and heart failure, especially in young children. Here, we describe 11 young patients (5–13 years) with a predominant presentation of dilated cardiomyopathy (DCM). Metabolic investigations showed deficient protein N-glycosylation, leading to a diagnosis of Congenital Disorders of Glycosylation (CDG). Homozygosity mapping in the consanguineous families showed a locus with two known genes in the N-glycosylation pathway. In all individuals, pathogenic mutations were identified in DOLK, encoding the dolichol kinase responsible for formation of dolichol-phosphate. Enzyme analysis in patients' fibroblasts confirmed a dolichol kinase deficiency in all families. In comparison with the generally multisystem presentation in CDG, the nonsyndromic DCM in several individuals was remarkable. Investigation of other dolichol-phosphate dependent glycosylation pathways in biopsied heart tissue indicated reduced O-mannosylation of alpha-dystroglycan with concomitant functional loss of its laminin-binding capacity, which has been linked to DCM. We thus identified a combined deficiency of protein N-glycosylation and alpha-dystroglycan O-mannosylation in patients with nonsyndromic DCM due to autosomal recessive DOLK mutations. PMID:22242004

Morava, Eva; Riemersma, Moniek; Schuurs-Hoeijmakers, Janneke H. M.; Absmanner, Birgit; Verrijp, Kiek; van den Akker, Willem M. R.; Huijben, Karin; Steenbergen, Gerry; van Reeuwijk, Jeroen; Jozwiak, Adam; Zucker, Nili; Lorber, Avraham; Lammens, Martin; Knopf, Carlos; van Bokhoven, Hans; Grünewald, Stephanie; Lehle, Ludwig; Kapusta, Livia; Mandel, Hanna; Wevers, Ron A.

2011-01-01

384

AAV-mediated gene therapy in mouse models of recessive retinal degeneration  

PubMed Central

In recent years, more and more mutant genes that cause retinal diseases have been detected. At the same time, many naturally occurring mouse models of retinal degeneration have also been found, which show similar changes to human retinal diseases. These, together with improved viral vector quality allow more and more traditionally incurable inherited retinal disorders to become potential candidates for gene therapy. Currently, the most common vehicle to deliver the therapeutic gene into target retinal cells is the adeno-associated viral vector (AAV). Following delivery to the immuno-priviledged subretinal space, AAV-vectors can efficiently target both retinal pigment epithelium and photoreceptor cells, the origin of most retinal degenerations. This review focuses on the AAV-based gene therapy in mouse models of recessive retinal degenerations, especially those in which delivery of the correct copy of the wild-type gene has led to significant beneficial effects on visual function, as determined by morphological, biochemical, electroretinographic and behavioral analysis. The past studies in animal models and ongoing successful LCA2 clinical trials, predict a bright future for AAV gene replacement treatment for inherited recessive retinal diseases. PMID:22300136

Pang, Ji-jing; Lei, Lei; Dai, Xufeng; Shi, Wei; Liu, Xuan; Dinculescu, Astra; McDowell, J. Hugh

2013-01-01

385

Two sisters reveal autosomal recessive inheritance of epidermodysplasia verruciformis: a case report  

PubMed Central

Background Epidermodysplasia verruciformis is a rare genodermatosis characterized by a unique susceptibility to cutaneous human papillomaviruses infection. Most patients show autosomal recessive patterns of inheritance. Case presentation We report a case of two sisters with clinically epidermodysplasia verruciformis specific lesions on the face, neck, trunk, and extremities. PCR analysis indicated the presence of human papillomavirus type 5 in the lesions. Electron microscopic examination showed viral-like particles in keratinocyte nuclei and the stratum corneum of the epidermodysplasia verruciformis lesions. In addition, we examined the EVER1 and EVER2 genes using eight different primer pairs without finding any nonsense or frameshift mutations in the gDNA from lymphocytes of the elder sister. Conclusions In this report, the patient’s parents did not have epidermodysplasia verruciformis lesions or a consanguineous marriage. EV did not develop in the elder sister until five years of age, so the parents did not perceive EV as an inherited disease. The probability that EV developed in both sisters was only 6.25%. Thus, it is rare for both sisters to develop epidermodysplasia verruciformis lesions considering that the parents were presumed to be carriers and the disease reveal an autosomal recessive pattern of inheritance. PMID:25048734

2014-01-01

386

A novel deletion mutation involving TMEM38B in a patient with autosomal recessive osteogenesis imperfecta.  

PubMed

Osteogenesis imperfecta (OI) is a hereditary bone disease characterized by decreased bone density and multiple fractures, usually inherited in an autosomal dominant manner. Several gene encoding proteins related to collagen metabolism have been described in some cases of autosomal recessive OI (including CRTAP, LEPRE1, PPIB, FKBP65, SERPINF1, BMP1, WNT1, FKBP10). Recently, TMEM38B, a gene that encodes TRIC-B, a monovalent cation-specific channel involved in calcium flux from intracellular stores and in cell differentiation, has been associated with autosomal recessive OI. Here, we describe the second deletion-mutation involving the TMEM38B gene in an 11 year-old Albanian female with a clinical phenotype of OI, born to parents with suspected consanguinity. SNP array analysis revealed a homozygous region larger than 2 Mb that overlapped with the TMEM38B locus and was characterized by a 35 kb homozygous deletion involving exons 1 and 2 of TMEM38B gene. PMID:24835313

Rubinato, Elisa; Morgan, Anna; D'Eustacchio, Angela; Pecile, Vanna; Gortani, Giulia; Gasparini, Paolo; Faletra, Flavio

2014-07-25

387

Mapping of both autosomal recessive and dominant variants of pseudoxanthoma elasticum to chromosome 16p13.1.  

PubMed

Pseudoxanthoma elasticum (PXE) is a classic inherited disorder of the elastic tissue characterized by progressive calcification of elastic fibers with a pathognomonic histological appearance. The clinical manifestations of PXE typically involve the skin, the eye and the cardiovascular system, resulting in skin lesions, decreased vision and vascular disease. Clinically, a more common autosomal recessive and a less common autosomal dominant pattern of inheritance, with high penetrance, have been described; the estimated prevalence of the disease is 1 in 70,000-100,000. Previous failure to link the disease to any of several candidate genes prompted us to conduct a genome-wide screen on a collection of 38 families with two or more affected siblings, using allele sharing algorithms. Excess allele sharing was found on the short arm of chromosome 16 and confirmed by conventional linkage analysis, localizing the disease gene under a recessive model with a maximum two point lod score of 21.27 on chromosome 16p13.1, an area so far devoid of any obvious candidate genes. Under a dominant transmission pattern linkage with a maximum two point lod score of 14.53 was observed to the same region. Linkage heterogeneity analysis predicted the presence of allelic heterogeneity with different variants of a single gene that resides in this chromosomal region accounting for recessive and dominant forms of PXE. PMID:9302259

Struk, B; Neldner, K H; Rao, V S; St Jean, P; Lindpaintner, K

1997-10-01

388

Numerical simulation of flows in curved diffusers with cross-sectional transitioning using a three-dimensional viscous analysis  

NASA Technical Reports Server (NTRS)

A three dimensional analysis for fully viscous, subsonic, compressible flow is evaluated. An approximate form of the Navier Stokes equations is solved by an implicit spatial marching technique. Calculations were made for flow in a circular S duct and in the F 16 inlet duct. The computed total pressure contours and secondary flow velocity vectors are presented. Qualitative comparisons with experiment are shown for both ducts. The analysis is used to show how the cross section transitioning in the F 16 inlet suppresses the development of a secondary flow vortex.

Towne, C. E.; Anderson, B. H.

1981-01-01

389

Analysis of Pure Tar Substances (Polycyclic Aromatic Hydrocarbons) in the Gas Stream Using Ultraviolet Visible (UV-Vis) Spectroscopy and Multivariate Curve Resolution (MCR).  

PubMed

The analysis of tar, mostly characterized as polycyclic aromatic hydrocarbons (PAHs), describes a topic that has been researched for years. An online analysis of tar in the gas stream in particular is needed to characterize the tar conversion or formation in the biomass gasification process. The online analysis in the gas is carried out with ultraviolet-visible (UV-Vis) spectroscopy (190-720 nm). This online analysis is performed with a measuring cell developed by the Fraunhofer Institute for Chemical Technology (ICT). To this day, online tar measurements using UV-Vis spectroscopy have not been carried out in detail. Therefore, PAHs are analyzed as follows. The measurements are split into different steps. The first step to prove the online method is to vaporize single tar substances. These experiments show that a qualitative analysis of PAHs in the gas stream with the used measurement setup is possible. Furthermore, it is shown that the method provides very exact results, so that a differentiation of various PAHs is possible. The next step is to vaporize a PAH mixture. This step consists of vaporizing five pure substances almost simultaneously. The interpretation of the resulting data is made using a chemometric interpretation method, the multivariate curve resolution (MCR). The verification of the calculated results is the main aim of this experiment. It has been shown that the tar mixture can be analyzed qualitatively and quantitatively (in arbitrary units) in detail using the MCR. Finally it is the main goal of this paper to show the first steps in the applicability of the UV-Vis spectroscopy and the measurement setup on online tar analysis in view of characterizing the biomass gasification process. Due to that, the gasification plant (at the laboratory scale), developed and constructed by the Fraunhofer ICT, has been used to vaporize these substances. Using this gasification plant for the experiments enables the usage of the measurement setup also for the spectroscopic analysis of the tar formation during the biomass gasification. PMID:25588231

Weide, Tobias; Guschin, Viktor; Becker, Wolfgang; Koelle, Sabine; Maier, Simon; Seidelt, Stephan

2015-01-01

390

Lateral epitaxial overgrowth of silicon over recessed oxide  

NASA Astrophysics Data System (ADS)

A silicon-on-insulator (SOI) technique, lateral epitaxial overgrowth (LEO), which has applications in VSLI and which provides material for 3-D circuits is described. It is shown that LEO of silicon in a recessed oxide structure results in a lateral to vertical growth ratio greater than five. The technique is particularly applicable if the application of SOI is for dielectric isolation and radiation hardness. Initial experiments with Rutherford backscattering spectrometry show that LEO-SOI films obtained by this technique have very good crystallinity.

Jayadev, T. S.; Okazaki, E.; Petersen, H.; Millman, M.

1985-04-01

391

STIL mutation causes autosomal recessive microcephalic lobar holoprosencephaly.  

PubMed

Holoprosencephaly is a clinically and genetically heterogeneous midline brain malformation associated with neurologic manifestations including developmental delay, intellectual disability and seizures. Although mutations in the sonic hedgehog gene SHH and more than 10 other genes are known to cause holoprosencephaly, many patients remain without a molecular diagnosis. Here we show that a homozygous truncating mutation of STIL not only causes severe autosomal recessive microcephaly, but also lobar holoprosencephaly in an extended consanguineous Pakistani family. STIL mutations have previously been linked to centrosomal defects in primary microcephaly at the MCPH7 locus. Our results thus expand the clinical phenotypes associated with biallellic STIL mutations to include holoprosencephaly. PMID:25218063

Kakar, Naseebullah; Ahmad, Jamil; Morris-Rosendahl, Deborah J; Altmüller, Janine; Friedrich, Katrin; Barbi, Gotthold; Nürnberg, Peter; Kubisch, Christian; Dobyns, William B; Borck, Guntram

2015-01-01

392

The Great Recession, genetic sensitivity, and maternal harsh parenting  

PubMed Central

Using data from the Fragile Families and Child Wellbeing Study, this study examined the effects of the Great Recession on maternal harsh parenting. We found that changes in macroeconomic conditions, rather than current conditions, affected harsh parenting, that declines in macroeconomic conditions had a stronger impact on harsh parenting than improvements in conditions, and that mothers’ responses to adverse economic conditions were moderated by the DRD2 Taq1A genotype. We found no evidence of a moderating effect for two other, less well-studied SNPs from the DRD4 and DAT1 genes. PMID:23918380

Lee, Dohoon; Brooks-Gunn, Jeanne; McLanahan, Sara S.; Notterman, Daniel; Garfinkel, Irwin

2013-01-01

393

Truncating neurotrypsin mutation in autosomal recessive nonsyndromic mental retardation.  

PubMed

A 4-base pair deletion in the neuronal serine protease neurotrypsin gene was associated with autosomal recessive nonsyndromic mental retardation (MR). In situ hybridization experiments on human fetal brains showed that neurotrypsin was highly expressed in brain structures involved in learning and memory. Immuno-electron microscopy on adult human brain sections revealed that neurotrypsin is located in presynaptic nerve endings, particularly over the presynaptic membrane lining the synaptic cleft. These findings suggest that neurotrypsin-mediated proteolysis is required for normal synaptic function and suggest potential insights into the pathophysiological bases of mental retardation. PMID:12459588

Molinari, Florence; Rio, Marlene; Meskenaite, Virginia; Encha-Razavi, Férechté; Augé, Joelle; Bacq, Delphine; Briault, Sylvain; Vekemans, Michel; Munnich, Arnold; Attié-Bitach, Tania; Sonderegger, Peter; Colleaux, Laurence

2002-11-29

394

A statistical model for the analysis and prediction of the effect of neutron irradiation on Charpy impact energy curves  

Microsoft Academic Search

The structural integrity safety assessments of nuclear reactor pressure vessels are based, in part, on a prediction of the effect of neutron irradiation on material properties. Databases which monitor this effect are often made up of Charpy absorbed energy measurements. This article presents a generally applicable, new and statistically rigorous method of analysis in which any prior belief as to

P. L. Windle; M. Crowder; R. Moskovic

1996-01-01

395

Assessing the Impact of Family Process on Rural African American Adolescents' Competence and Behavior Using Latent Growth Curve Analysis  

ERIC Educational Resources Information Center

A study examines the long-term effects of a family process program on social and cognitive competence and aggressive and deviant behavior among rural African American adolescents. Results suggest that family processes influence the status and changes in adolescent competence and behavior, while analysis of covariant structures suggest that…

Toldson, Ivory A.

2006-01-01

396

Severity of Prenatal Cocaine Exposure and Child Language Functioning Through Age Seven Years: A Longitudinal Latent Growth Curve Analysis  

PubMed Central

The current study estimates the longitudinal effects of severity of prenatal cocaine exposure on language functioning in an urban sample of full-term African-American children (200 cocaine-exposed, 176 noncocaine-exposed) through age 7 years. The Miami Prenatal Cocaine Study sample was enrolled prospectively at birth, with documentation of prenatal drug exposure status through maternal interview and toxicology assays of maternal and infant urine and infant meconium. Language functioning was measured at ages 3 and 5 years using the Clinical Evaluation of Language Fundamentals–Preschool (CELF-P) and at age 7 years using the Core Language Domain of the NEPSY: A Developmental Neuropsychological Assessment. Longitudinal latent growth curve analyses were used to examine two components of language functioning, a more stable aptitude for language performance and a time-varying trajectory of language development, across the three time points and their relationship to varying levels of prenatal cocaine exposure. Severity of prenatal cocaine exposure was characterized using a latent construct combining maternal self-report of cocaine use during pregnancy by trimesters and maternal and infant bioassays, allowing all available information to be taken into account. The association between severity of exposure and language functioning was examined within a model including factors for fetal growth, gestational age, and IQ as intercorrelated response variables and child’s age, gender, and prenatal alcohol, tobacco, and marijuana exposure as covariates. Results indicated that greater severity of prenatal cocaine exposure was associated with greater deficits within the more stable aptitude for language performance (D = ?0.071, 95% CI = ?0.133, ?0.009; p = 0.026). There was no relationship between severity of prenatal cocaine exposure and the time-varying trajectory of language development. The observed cocaine-associated deficit was independent of multiple alternative suspected sources of variation in language performance, including other potential responses to prenatal cocaine exposure, such as child’s intellectual functioning, and other birth and postnatal influences, including language stimulation in the home environment. PMID:15002943

Bandstra, Emmalee S.; Vogel, April L.; Morrow, Connie E.; Xue, Lihua; Anthony, James C.

2009-01-01

397

Atmospheric Stability Impacts on Power Curves of Tall Wind Turbines - An Analysis of a West Coast North American Wind Farm  

SciTech Connect

Tall wind turbines, with hub heights at 80 m or above, can extract large amounts of energy from the atmosphere because they are likely to encounter higher wind speeds, but they face challenges given the complex nature of wind flow and turbulence at these heights in the boundary layer. Depending on whether the boundary layer is stable, neutral, or convective, the mean wind speed, direction, and turbulence properties may vary greatly across the tall turbine swept area (40 to 120 m AGL). This variability can cause tall turbines to produce difference amounts of power during time periods with identical hub height wind speeds. Using meteorological and power generation data from a West Coast North American wind farm over a one-year period, our study synthesizes standard wind park observations, such as wind speed from turbine nacelles and sparse meteorological tower observations, with high-resolution profiles of wind speed and turbulence from a remote sensing platform, to quantify the impact of atmospheric stability on power output. We first compare approaches to defining atmospheric stability. The standard, limited, wind farm operations enable the calculation only of a wind shear exponent ({alpha}) or turbulence intensity (I{sub U}) from cup anemometers, while the presence at this wind farm of a SODAR enables the direct observation of turbulent kinetic energy (TKE) throughout the turbine rotor disk. Additionally, a nearby research meteorological station provided observations of the Obukhov length, L, a direct measure of atmospheric stability. In general, the stability parameters {alpha}, I{sub U}, and TKE are in high agreement with the more physically-robust L, with TKE exhibiting the best agreement with L. Using these metrics, data periods are segregated by stability class to investigate power performance dependencies. Power output at this wind farm is highly correlated with atmospheric stability during the spring and summer months, while atmospheric stability exerts little impact on power output during the winter and autumn periods. During the spring and summer seasons, power output for a given wind speed was significantly higher during stable conditions and significantly lower during strongly convective conditions: power output differences approached 20% between stable and convective regimes. The dependency of stability on power output was apparent only when both turbulence and the shape of the wind speed profile were considered. Turbulence is one of the mechanisms by which atmospheric stability affects a turbine's power curve at this particular site, and measurements of turbulence can yield actionable insights into wind turbine behavior.

Wharton, S; Lundquist, J K

2010-02-22

398

Quantitative analysis of biodiesel in blends of biodiesel and conventional diesel by comprehensive two-dimensional gas chromatography and multivariate curve resolution.  

PubMed

In this paper, a method to determine the composition of blends of biodiesel with mineral diesel (BXX) by multivariate curve resolution with Alternating Least Squares (MRC-ALS) combined to comprehensive two-dimensional gas chromatography with Flame Ionization Detection (GC×GC-FID) is presented. Chromatographic profiles of BXX blends produced with biodiesels from different sources were used as input data. An initial evaluation carried out after multiway principal component analysis (MPCA) was used to reveal regions of the chromatograms were the signal was likely to be dependent on the concentration of biodiesel, regardless its vegetable source. After this preliminary step MCR-ALS modeling was carried out only using relevant parts of the chromatograms. The resulting procedure was able to predict accurately the concentration of biodiesel in the BXX samples regardless of its origin. PMID:24016593

Mogollon, Noroska Gabriela Salazar; Ribeiro, Fabiana Alves de Lima; Lopez, Monica Mamian; Hantao, Leandro Wang; Poppi, Ronei Jesus; Augusto, Fabio

2013-09-24

399

Analysis of the width-[Formula: see text] non-adjacent form in conjunction with hyperelliptic curve cryptography and with lattices.  

PubMed

In this work the number of occurrences of a fixed non-zero digit in the width-[Formula: see text] non-adjacent forms of all elements of a lattice in some region (e.g. a ball) is analysed. As bases, expanding endomorphisms with eigenvalues of the same absolute value are allowed. Applications of the main result are on numeral systems with an algebraic integer as base. Those come from efficient scalar multiplication methods (Frobenius-and-add methods) in hyperelliptic curves cryptography, and the result is needed for analysing the running time of such algorithms. The counting result itself is an asymptotic formula, where its main term coincides with the full block length analysis. In its second order term a periodic fluctuation is exhibited. The proof follows Delange's method. PMID:23805020

Krenn, Daniel

2013-06-17

400

Rapid genotyping of Achromobacter xylosoxidans, Acinetobacter baumannii, Klebsiella pneumoniae, Pseudomonas aeruginosa and Stenotrophomonas maltophilia isolates using melting curve analysis of RAPD-generated DNA fragments (McRAPD).  

PubMed

Typing of bacteria is important for monitoring newly emerging pathogens and for examining local outbreaks. We evaluated the randomly amplified polymorphic DNA technique in combination with melting curve analysis (McRAPD) of the amplified DNA fragments to genotype isolates from five Gram-negative species, i.e. Achromobacter xylosoxidans, Acinetobacter baumannii, Klebsiella pneumoniae, Pseudomonas aeruginosa and Stenotrophomonas maltophilia. By determining the melting temperature peaks of the amplified DNA fragments, we were able to distinguish the different genotypes of isolates, as they had been assessed by other genotyping techniques, i.e. agarose gel electrophoresis of RAPD fragments, multilocus sequence typing and/or AFLP™. According to our results, McRAPD may offer the possibility of genotyping a limited number of bacterial isolates, e.g. in case of suspicion of hospital outbreak, via a less costly, more rapid, less laborious and more user-friendly technique than RAPD followed by electrophoresis. PMID:21320595

Deschaght, Pieter; Van Simaey, Leen; Decat, Ellen; Van Mechelen, Els; Brisse, Sylvain; Vaneechoutte, Mario

2011-05-01

401

Diagnosis and identification of Leishmania spp. from Giemsa-stained slides, by real-time PCR and melting curve analysis in south-west of Iran  

PubMed Central

Background: The aim of present study was describing a real-time PCR assay for the diagnosis and direct identification of Leishmania species on Giemsa-stained slides in south-west of Iran. Materials and methods: Altogether, 102 Giemsa-stained slides were collected from different part of south-west of Iran between 2008 and 2011. All the Giemsa-stained slides were examined under light microscope. After DNA extraction, real-time PCR amplification and detection were conducted with fluorescent SYBR Green I. For identification, PCR products were analysed with melting curve analysis. Results: One hundred and two archived slides from suspected lesion examined by microscopy and real-time PCR. The sensitivity of the real-time PCR on Giemsa-stained slid was 98% (96/102). The melting curve analysis (Tm) were 88.3±0.2°C for L. tropica (MHOM/IR/02/Mash10), 86.5±0.2°C for L. major (MHOM/IR/75/ER) and 89.4±0.3°C for L. infantum (MCAN/IR/97/LON 49), respectively. Conclusion: This study is first report in use of real-time PCR for diagnosis and identification of Leishmania spp. in Iran. Up to now, in Iran, the majority of identification of Leishmania species is restriction fragment length polymorphism (PCR-RFLP) of ITS1 and kinetoplast DNA. Our data showed that Giemsa-stained slides that were stored more than 3 years, can be use for Leishmania DNA extraction and amplification by real-time PCR. Compared to conventional PCR-based methods, the real-time PCR is extremely rapid with results and more samples can be processed at one time. PMID:22325815

Khademvatan, S; Neisi, N; Maraghi, S; Saki, J

2011-01-01

402

Buckling of a Longitudinally Jointed Curved Composite Panel Arc Segment for Next Generation of Composite Heavy Lift Launch Vehicles: Verification Testing Analysis  

NASA Technical Reports Server (NTRS)

In this work, an all-bonded out-of-autoclave (OoA) curved longitudinal composite joint concept, intended for use in the next generation of composite heavy lift launch vehicles, was evaluated and verified through finite element (FE) analysis, fabrication, testing, and post-test inspection. The joint was used to connect two curved, segmented, honeycomb sandwich panels representative of a Space Launch System (SLS) fairing design. The overall size of the resultant panel was 1.37 m by 0.74 m (54 in by 29 in), of which the joint comprised a 10.2 cm (4 in) wide longitudinal strip at the center. NASTRAN and ABAQUS were used to perform linear and non-linear analyses of the buckling and strength performance of the jointed panel. Geometric non-uniformities (i.e., surface contour imperfections) were measured and incorporated into the FE model and analysis. In addition, a sensitivity study of the specimens end condition showed that bonding face-sheet doublers to the panel's end, coupled with some stress relief features at corner-edges, can significantly reduce the stress concentrations near the load application points. Ultimately, the jointed panel was subjected to a compressive load. Load application was interrupted at the onset of buckling (at 356 kN 80 kips). A post-test non-destructive evaluation (NDE) showed that, as designed, buckling occurred without introducing any damage into the panel or the joint. The jointed panel was further capable of tolerating an impact damage to the same buckling load with no evidence of damage propagation. The OoA cured all-composite joint shows promise as a low mass factory joint for segmented barrels.

Farrokh, Babak; Segal, Kenneth N.; Akkerman, Michael; Glenn, Ronald L.; Rodini, Benjamin T.; Fan, Wei-Ming; Kellas, Sortiris; Pineda, Evan J.

2014-01-01

403

High-Resolution DNA Melt Curve Analysis of the Clustered, Regularly Interspaced Short-Palindromic-Repeat Locus of Campylobacter jejuni  

Microsoft Academic Search

A novel method for genotyping the clustered, regularly interspaced short-palindromic-repeat (CRISPR) locus of Campylobacter jejuni is described. Following real-time PCR, CRISPR products were subjected to high-resolution melt (HRM) analysis, a new technology that allows precise melt profile determination of amplicons. This investigation shows that the CRISPR HRM assay provides a powerful addition to existing C. jejuni genotyping methods and emphasizes

Erin P. Price; Helen Smith; Flavia Huygens; Philip M. Giffard

2007-01-01

404

Tag, catch, and other unnatural acts at recess (Circa 2014).  

PubMed

This commentary details a news event in which Carrie Weber Middle School in Port Washington, NY, supposedly banned students from using balls, playing tag, and doing cartwheels during recess. Public reaction in the form of news items, tweets, blogs, and commentary is sampled, and news releases from the Weber Middle School that were barely covered by the media and explain their decision to ban hardballs from 20-min recess are brought to light. The commentary then goes on to argue that such trending news events can be interpreted in terms of complex cultural histories, including in the case of Weber Middle School, much intellectual thought pioneered by human movement scholarship. Ideas about social nostalgia and memory, play, hegemony, invention of tradition, and cultural context are overviewed in light of their use in human movement studies and in interpreting the Weber Middle School issue. It is argued that current issues and initiatives surrounding obesity and sport for peace and development are, like the trending Weber Middle School news, sometimes not mapped or critiqued (terms coined by Markula-Denison and Silk in 2011) in the profound ways that cultural studies urge. The commentary ends in a call to scholars and practitioners of human movement studies for self-reflexivity and purposeful awareness of changing social definitions of the "unnatural." PMID:24749229

Sydnor, Synthia

2014-03-01

405

Chemical carcinogens transform BHK cells by inducing a recessive mutation.  

PubMed Central

Treatment of BHK cells with mutagenic carcinogens induced neoplastic transformation in a single step. This transformation displayed the characteristics expected for a recessive mutation. Increasing doses of carcinogens induced transformants with kinetics similar to the kinetics with which they induced 6-thioguanine-resistant or ouabain-resistant mutants in the same population of cells. Transformants with temperature-restricted phenotypes were easily induced by carcinogens which cause mutations by base changes, but when ICR frameshift mutagens were used, the proportion of temperature-limited transformants was inversely related to the frequency with which a particular mutagen induced frameshift mutations. In hybrids between pseudodiploid isogenic strains of normal and transformed BHK cells, transformation was expressed as a dominant trait when the transformed parent was induced by a papovavirus, but was suppressed as a recessive trait when the transformed parent arose spontaneously or was chemically induced. Segregation of transformation was observed upon growth of suppressed normal hybrids, and the transformed phenotype which was reexpressed was in most cases characteristics of the original transformed parent. PMID:6810094

Bouck, N; di Mayorca, G

1982-01-01

406

NDST1 missense mutations in autosomal recessive intellectual disability.  

PubMed

NDST1 was recently proposed as a candidate gene for autosomal recessive intellectual disability in two families. It encodes a bifunctional GlcNAc N-deacetylase/N-sulfotransferase with important functions in heparan sulfate biosynthesis. In mice, Ndst1 is crucial for embryonic development and homozygous null mutations are perinatally lethal. We now report on two additional unrelated families with homozygous missense NDST1 mutations. All mutations described to date predict the substitution of conserved amino acids in the sulfotransferase domain, and mutation modeling predicts drastic alterations in the local protein conformation. Comparing the four families, we noticed significant overlap in the clinical features, including both demonstrated and apparent intellectual disability, muscular hypotonia, epilepsy, and postnatal growth deficiency. Furthermore, in Drosophila, knockdown of sulfateless, the NDST ortholog, impairs long-term memory, highlighting its function in cognition. Our data confirm NDST1 mutations as a cause of autosomal recessive intellectual disability with a distinctive phenotype, and support an important function of NDST1 in human development. PMID:25125150

Reuter, Miriam S; Musante, Luciana; Hu, Hao; Diederich, Stefan; Sticht, Heinrich; Ekici, Arif B; Uebe, Steffen; Wienker, Thomas F; Bartsch, Oliver; Zechner, Ulrich; Oppitz, Cornelia; Keleman, Krystyna; Jamra, Rami Abou; Najmabadi, Hossein; Schweiger, Susann; Reis, André; Kahrizi, Kimia

2014-11-01

407

Development of a High-Resolution Melting Curve Analysis Screening Test for SRSF2 Splicing Factor Gene Mutations in Myelodysplastic Syndromes.  

PubMed

Somatic mutations of the spliceosome machinery have been recently identified by whole genome analysis in hematologic diseases, such as myelodysplastic syndrome, chronic lymphocytic leukemia, myeloproliferative neoplasms, acute myeloid leukemia, and advanced forms of mastocytosis, and also in nonhematologic conditions. SRSF2 is a member of the serine/arginine-rich family pre-mRNA splicing factors that plays a role in mRNA export from the nucleus and translation. We describe a high-resolution melting (HRM) curve analysis to screen for SRSF2 hotspot mutations in a fast, sensitive, and reliable way. Fifty bone marrow samples from patients with myelodysplastic syndrome were analyzed by the HRM assay and by direct sequencing. HRM screening identified four melting patterns corresponding to a negative (wild-type) group and three different mutated groups. Each mutated group was identified according to the positive control used: P95H, P95L, and P95R, respectively. An HRM mutated pattern was identified in seven patients. Positive and negative results from HRM were compared with direct sequencing results with a sensitivity and specificity of 100% (95% CI, 0.56-1, and 95% CI, 0.89-1, respectively). Analytical sensitivity analysis revealed a detection threshold of up to 1:9 (mutated/wild type) dilution. This rapid screening method may provide useful information for clinical decision making and be helpful to optimize laboratory resources and reduce turnaround time. PMID:25445211

Garza, Eduardo; Fabiani, Emiliano; Noguera, Nelida; Panetta, Paola; Piredda, Maria L; Borgia, Loredana; Maurillo, Luca; Catalano, Gianfranco; Voso, Maria T; Lo-Coco, Francesco

2015-01-01

408

Deletions of recessive disease genes: CNV contribution to carrier states and disease-causing alleles  

PubMed Central

Over 1200 recessive disease genes have been described in humans. The prevalence, allelic architecture, and per-genome load of pathogenic alleles in these genes remain to be fully elucidated, as does the contribution of DNA copy-number variants (CNVs) to carrier status and recessive disease. We mined CNV data from 21,470 individuals obtained by array-comparative genomic hybridization in a clinical diagnostic setting to identify deletions encompassing or disrupting recessive disease genes. We identified 3212 heterozygous potential carrier deletions affecting 419 unique recessive disease genes. Deletion frequency of these genes ranged from one occurrence to 1.5%. When compared with recessive disease genes never deleted in our cohort, the 419 recessive disease genes affected by at least one carrier deletion were longer and located farther from known dominant disease genes, suggesting that the formation and/or prevalence of carrier CNVs may be affected by both local and adjacent genomic features and by selection. Some subjects had multiple carrier CNVs (307 subjects) and/or carrier deletions encompassing more than one recessive disease gene (206 deletions). Heterozygous deletions spanning multiple recessive disease genes may confer carrier status for multiple single-gene disorders, for complex syndromes resulting from the combination of two or more recessive conditions, or may potentially cause clinical phenotypes due to a multiply heterozygous state. In addition to carrier mutations, we identified homozygous and hemizygous deletions potentially causative for recessive disease. We provide further evidence that CNVs contribute to the allelic architecture of both carrier and recessive disease-causing mutations. Thus, a complete recessive carrier screening method or diagnostic test should detect CNV alleles. PMID:23685542

Boone, Philip M.; Campbell, Ian M.; Baggett, Brett C.; Soens, Zachry T.; Rao, Mitchell M.; Hixson, Patricia M.; Patel, Ankita; Bi, Weimin; Cheung, Sau Wai; Lalani, Seema R.; Beaudet, Arthur L.; Stankiewicz, Pawel; Shaw, Chad A.; Lupski, James R.

2013-01-01

409

Identification of novel GDAP1 mutations causing autosomal recessive Charcot-Marie-Tooth disease  

Microsoft Academic Search

Mutations in the ganglioside-induced differentiation-associated protein 1 gene cause either autosomal recessive demyelinating Charcot-Marie-Tooth disease type 4A or autosomal recessive axonal Charcot-Marie-Tooth disease with vocal cord paresis. We sequenced the ganglioside-induced differentiation-associated protein 1 gene in 138 patients from 119 unrelated families diagnosed with either demyelinating or axonal autosomal recessive Charcot-Marie-Tooth disease. We detected six distinct mutant alleles in four

Nadia Ammar; Eva Nelis; Luciano Merlini; Nina Bariši?; Rim Amouri; Chantal Ceuterick; Jean-Jacques Martin; Vincent Timmerman; Fayçal Hentati; Peter De Jonghe

2003-01-01

410

Spatially distributed characterization of hyporheic solute transport during baseflow recession in a headwater mountain stream using electrical geophysical imaging  

NASA Astrophysics Data System (ADS)

The transport of solutes along hyporheic flowpaths is recognized as central to numerous biogeochemical cycles, yet our understanding of how this transport changes with baseflow recession, particularly in a spatially distributed manner, is limited. We conducted four steady-state solute tracer injections and collected electrical resistivity data to characterize hyporheic transport during seasonal baseflow recession in the H.J. Andrews Experimental Forest (Oregon, USA). We used temporal moment analysis of pixels generated from inversion of electrical resistivity data to compress time-lapse data into descriptive statistics (mean arrival time, temporal variance, and temporal skewness) for each pixel. A spatial visualization of these temporal moments in the subsurface at each of five 2-D transects perpendicular to the stream was interpreted to inform transport processes. As baseflow recession progressed we found increasing first arrival times, persistence, mean arrival time, temporal variance, and coefficient of variation, and decreasing skewness. These trends suggest that changes in hydrologic forcing alter the relative influence of transport phenomena (e.g., advection vs. other transport processes such as dispersion) along flowpaths. Spatial coverage obtained from electrical resistivity images allowed for qualitative comparison of spatial patterns in temporal moments both at an individual cross-section as well as between cross sections. We found that geomorphologic controls (e.g., bedrock confinement vs. gravel wedge deposits) resulted in different distributions and metrics of hyporheic transport. Results of this study provide further evidence that hyporheic transport is highly variable both in space and through the baseflow recession period. Geophysical images differentiate advection-dominated flowpaths from those that are more affected by other transport processes (e.g., dispersion, mobile-immobile exchange).

Ward, Adam S.; Gooseff, Michael N.; Fitzgerald, Michael; Voltz, Thomas J.; Singha, Kamini

2014-09-01

411

Evidence of Recessive Alzheimer Disease Loci in a Caribbean Hispanic Data Set  

PubMed Central

IMPORTANCE The search for novel Alzheimer disease (AD) genes or pathologic mutations within known AD loci is ongoing. The development of array technologies has helped to identify rare recessive mutations among long runs of homozygosity (ROHs), in which both parental alleles are identical. Caribbean Hispanics are known to have an elevated risk for AD and tend to have large families with evidence of inbreeding. OBJECTIVE To test the hypothesis that the late-onset AD in a Caribbean Hispanic population might be explained in part by the homozygosity of unknown loci that could harbor recessive AD risk haplotypes or pathologic mutations. DESIGN We used genome-wide array data to identify ROHs (>1 megabase) and conducted global burden and locus-specific ROH analyses. SETTING A whole-genome case-control ROH study. PARTICIPANTS A Caribbean Hispanic data set of 547 unrelated cases (48.8% with familial AD) and 542 controls collected from a population known to have a 3-fold higher risk of AD vs non-Hispanics in the same community. Based on a Structure program analysis, our data set consisted of African Hispanic (207 cases and 192 controls) and European Hispanic (329 cases and 326 controls) participants. EXPOSURE Alzheimer disease risk genes. MAIN OUTCOMES AND MEASURES We calculated the total and mean lengths of the ROHs per sample. Global burden measurements among autosomal chromosomes were investigated in cases vs controls. Pools of overlapping ROH segments (consensus regions) were identified, and the case to control ratio was calculated for each consensus region. We formulated the tested hypothesis before data collection. RESULTS In total, we identified 17 137 autosomal regions with ROHs. The mean length of the ROH per person was significantly greater in cases vs controls (P = .0039), and this association was stronger with familial AD (P = .0005). Among the European Hispanics, a consensus region at the EXOC4 locus was significantly associated with AD even after correction for multiple testing (empirical P value 1 [EMP1], .0001; EMP2, .002; 21 AD cases vs 2 controls). Among the African Hispanic subset, the most significant but nominal association was observed for CTNNA3, a well-known AD gene candidate (EMP1, .002; 10 AD cases vs 0 controls). CONCLUSIONS AND RELEVANCE Our results show that ROHs could significantly contribute to the etiology of AD. Future studies would require the analysis of larger, relatively inbred data sets that might reveal novel recessive AD genes. The next step is to conduct sequencing of top significant loci in a subset of samples with overlapping ROHs. PMID:23978990

Ghani, Mahdi; Sato, Christine; Lee, Joseph H.; Reitz, Christiane; Moreno, Danielle; Mayeux, Richard; St George-Hyslop, Peter; Rogaeva, Ekaterina

2014-01-01

412

On nondegeneracy of curves  

Microsoft Academic Search

A curve is called nondegenerate if it can be modeled by a Laurent polynomial\\u000athat is nondegenerate with respect to its Newton polytope. We show that up to\\u000agenus 4, every curve is nondegenerate. We also prove that the locus of\\u000anondegenerate curves inside the moduli space of curves of fixed genus g > 1 is\\u000amin(2g+1,3g-3)-dimensional, except in case

Wouter Castryck; John Voight

2009-01-01

413

Characterization of a new full length TMPRSS3 isoform and identification of mutant alleles responsible for nonsyndromic recessive deafness in Newfoundland and Pakistan  

PubMed Central

Background Mutant alleles of TMPRSS3 are associated with nonsyndromic recessive deafness (DFNB8/B10). TMPRSS3 encodes a predicted secreted serine protease, although the deduced amino acid sequence has no signal peptide. In this study, we searched for mutant alleles of TMPRSS3 in families from Pakistan and Newfoundland with recessive deafness co-segregating with DFNB8/B10 linked haplotypes and also more thoroughly characterized the genomic structure of TMPRSS3. Methods We enrolled families segregating recessive hearing loss from Pakistan and Newfoundland. Microsatellite markers flanking the TMPRSS3 locus were used for linkage analysis. DNA samples from participating individuals were sequenced for TMPRSS3. The structure of TMPRSS3 was characterized bioinformatically and experimentally by sequencing novel cDNA clones of TMPRSS3. Results We identified mutations in TMPRSS3 in four Pakistani families with recessive, nonsyndromic congenital deafness. We also identified two recessive mutations, one of which is novel, of TMPRSS3 segregating in a six-generation extended family from Newfoundland. The spectrum of TMPRSS3 mutations is reviewed in the context of a genotype-phenotype correlation. Our study also revealed a longer isoform of TMPRSS3 with a hitherto unidentified exon encoding a signal peptide, which is expressed in several tissues. Conclusion Mutations of TMPRSS3 contribute to hearing loss in many communities worldwide and account for 1.8% (8 of 449) of Pakistani families segregating congenital deafness as an autosomal recessive trait. The newly identified TMPRSS3 isoform e will be helpful in the functional characterization of the full length protein. PMID:15447792

Ahmed, Zubair M; Cindy Li, Xiaoyan; Powell, Shontell D; Riazuddin, Saima; Young, Terry-Lynn; Ramzan, Khushnooda; Ahmad, Zahoor; Luscombe, Sandra; Dhillon, Kiran; MacLaren, Linda; Ploplis, Barbara; Shotland, Lawrence I; Ives, Elizabeth; Riazuddin, Sheikh; Friedman, Thomas B; Morell, Robert J; Wilcox, Edward R

2004-01-01

414

X-linked recessive panhypopituitarism associated with a regional duplication in Xq25-q26.  

PubMed Central

We present a linkage analysis and a clinical update on a previously reported family with X-linked recessive panhypopituitarism, now in its fourth generation. Affected members exhibit variable degrees of hypopituitarism and mental retardation. The markers DXS737 and DXS1187 in the q25-q26 region of the X chromosome showed evidence for linkage with a peak LOD score (Zmax) of 4.12 at zero recombination fraction (theta(max) = 0). An apparent extra copy of the marker DXS102, observed in the region of the disease gene in affected males and heterozygous carrier females, suggests that a segment including this marker is duplicated. The gene causing this disorder appears to code for a dosage-sensitive protein central to development of the pituitary. Images Figure 2 PMID:9106538

Lagerström-Fermér, M; Sundvall, M; Johnsen, E; Warne, G L; Forrest, S M; Zajac, J D; Rickards, A; Ravine, D; Landegren, U; Pettersson, U

1997-01-01

415

Recessive Mutations in COL25A1 Are a Cause of Congenital Cranial Dysinnervation Disorder.  

PubMed

Abnormal ocular motility is a common clinical feature in congenital cranial dysinnervation disorder (CCDD). To date, eight genes related to neuronal development have been associated with different CCDD phenotypes. By using linkage analysis, candidate gene screening, and exome sequencing, we identified three mutations in collagen, type XXV, alpha 1 (COL25A1) in individuals with autosomal-recessive inheritance of CCDD ophthalmic phenotypes. These mutations affected either stability or levels of the protein. We further detected altered levels of sAPP (neuronal protein involved in axon guidance and synaptogenesis) and TUBB3 (encoded by TUBB3, which is mutated in CFEOM3) as a result of null mutations in COL25A1. Our data suggest that lack of COL25A1 might interfere with molecular pathways involved in oculomotor neuron development, leading to CCDD phenotypes. PMID:25500261

Shinwari, Jameela M A; Khan, Arif; Awad, Salma; Shinwari, Zakia; Alaiya, Ayodele; Alanazi, Mohamad; Tahir, Asma; Poizat, Coralie; Al Tassan, Nada

2015-01-01

416

New Recessive Syndrome of Microcephaly, Cerebellar Hypoplasia, and Congenital Heart Conduction Defect  

PubMed Central

We identified a two-branch consanguineous family in which four affected members (three females and one male) presented with constitutive growth delay, severe psychomotor retardation, microcephaly, cerebellar hypoplasia, and second-degree heart block. They also shared distinct facial features and similar appearance of their hands and feet. Childhood-onset insulin-dependent diabetes mellitus developed in one affected child around the age of 9 years. Molecular analysis excluded mutations in potentially related genes such as PTF1A, EIF2AK3, EOMES, and WDR62. This condition appears to be unique of other known conditions, suggesting a unique clinical entity of autosomal recessive mode of inheritance. © 2011 Wiley Periodicals, Inc. PMID:22002884

Zaki, Maha S; Salam, Ghada M H Abdel; Saleem, Sahar N; Dobyns, William B; Issa, Mahmoud Y; Sattar, Shifteh; Gleeson, Joseph G

2011-01-01

417

A gene for congenital, recessive deafness DFNB3 maps to the pericentromeric region of chromosome 17.  

PubMed

Two percent of the residents of Bengkala, Bali, have profound, congenital, neurosensory, nonsyndromal deafness due to an autosomal recessive mutation at the DFNB3 locus. We have employed a direct genome-wide disequilibrium search strategy, allele-frequency-dependent homozygosity mapping (AHM), and an analysis of historical recombinants to map DFNB3 and position the locus relative to flanking markers. DFNB3 maps to chromosome 17, closest to D17S261, pRM7-GT and D17S805. In individuals homozygous for DFNB3, historical recombinant genotypes for the flanking markers, D17S122 and D17S783, place DFNB3 in a 5.3 cM interval of the pericentromeric region of chromosome 17 on a refined linkage map of 17p-17q12. Based on conserved synteny, the murine sh2 gene may be the homologue of DFNB3. PMID:7704031

Friedman, T B; Liang, Y; Weber, J L; Hinnant, J T; Barber, T D; Winata, S; Arhya, I N; Asher, J H

1995-01-01

418

The Prompt-afterglow Connection in Gamma-ray Bursts: a Comprehensive Statistical Analysis of Swift X-ray Light-curves  

NASA Technical Reports Server (NTRS)

We present a comprehensive statistical analysis of Swift X-ray light-curves of Gamma- Ray Bursts (GRBs) collecting data from more than 650 GRBs discovered by Swift and other facilities. The unprecedented sample size allows us to constrain the rest-frame X-ray properties of GRBs from a statistical perspective, with particular reference to intrinsic time scales and the energetics of the different light-curve phases in a common rest-frame 0.3-30 keV energy band. Temporal variability episodes are also studied and their properties constrained. Two fundamental questions drive this effort: i) Does the X-ray emission retain any kind of "memory" of the prompt ?-ray phase? ii) Where is the dividing line between long and short GRB X-ray properties? We show that short GRBs decay faster, are less luminous and less energetic than long GRBs in the X-rays, but are interestingly characterized by similar intrinsic absorption. We furthermore reveal the existence of a number of statistically significant relations that link the X-ray to prompt ?-ray parameters in long GRBs; short GRBs are outliers of the majority of these 2-parameter relations. However and more importantly, we report on the existence of a universal 3-parameter scaling that links the X-ray and the ?-ray energy to the prompt spectral peak energy of both long and short GRBs: E(sub X,iso)? E(sup 1.00+/-0.06)(sub ?,iso) /E(sup 0.60+/-0.10)(sub pk).

Margutti, R.; Zaninoni, E.; Bernardini, M. G.; Chincarini, G.; Pasotti, F.; Guidorzi, C.; Angelini, Lorella; Burrows, D. N.; Capalbi, M.; Evans, P. A.; Gehrels, Neil; Kennea, J.; Mangano, V.; Moretti, A.; Nousek, J.; Osborne, J. P.; Page, K. L.; Perri, M.; Racusin, Judith Lea; Romano, P.; Sbarufatti, B.; Stafford, M.; Stamatikos, Michael

2012-01-01

419

Sex differences in the prediction of the effectiveness of paroxetine for patients with major depressive disorder identified using a receiver operating characteristic curve analysis for early response  

PubMed Central

Background We investigated cutoff values for the early response of patients with major depressive disorder to paroxetine and their sex differences by using a receiver operating characteristic (ROC) curve analysis to predict the effectiveness of paroxetine. Methods In total, 120 patients with major depressive disorder were enrolled and treated with 10–40 mg/day paroxetine for 6 weeks; 89 patients completed the protocol. A clinical evaluation using the Montgomery–Asberg Depression Rating Scale (MADRS) was performed at weeks 0, 1, 2, 4, and 6. Results In male subjects, the cutoff values for MADRS improvement rating in week 1, week 2, and week 4 were 20.9%, 34.9%, and 33.3%, respectively. The sensitivities and the specificities were 83.3% and 80.0%, 83.3% and 80.0%, and 100% and 90%, respectively. The areas under the curve (AUC) were 0.908, 0.821, and 0.979, respectively. In female subjects, the cutoff values for the MADRS improvement rating in week 1, week 2, and week 4 were 21.4%, 35.7%, and 32.3%, respectively. The sensitivities and the specificities were 71.4% and 84.6%, 73.8% and 76.9%, and 90.5% and 76.9%, respectively. The AUCs were 0.781, 0.735, and 0.904, respectively. Conclusion Early improvement with paroxetine may predict the long-term response. The accuracy of the prediction for the response is higher in male subjects. PMID:24748795

Tomita, Tetsu; Norio, Yasui-Furukori; Sato, Yasushi; Nakagami, Taku; Tsuchimine, Shoko; Kaneda, Ayako; Kaneko, Sunao

2014-01-01

420

Trends in electric utility load duration curves  

SciTech Connect

This report documents the development and analysis of annual and quarterly load duration curves for each of the 10 Federal regions. The report describes analyses performed to test for changes in load duration curve shapes over time. These analyses are intended to aid the electric utility analyses and modeling activities of the Energy Information Administration (EIA) by expanding the understanding of current and expected load duration curve shapes. 7 figs., 13 tabs.

Not Available

1984-12-01

421

Recessive mutations in SPTBN2 implicate ?-III spectrin in both cognitive and motor development.  

PubMed

?-III spectrin is present in the brain and is known to be important in the function of the cerebellum. Heterozygous mutations in SPTBN2, the gene encoding ?-III spectrin, cause Spinocerebellar Ataxia Type 5 (SCA5), an adult-onset, slowly progressive, autosomal-dominant pure cerebellar ataxia. SCA5 is sometimes known as "Lincoln ataxia," because the largest known family is descended from relatives of the United States President Abraham Lincoln. Using targeted capture and next-generation sequencing, we identified a homozygous stop codon in SPTBN2 in a consanguineous family in which childhood developmental ataxia co-segregates with cognitive impairment. The cognitive impairment could result from mutations in a second gene, but further analysis using whole-genome sequencing combined with SNP array analysis did not reveal any evidence of other mutations. We also examined a mouse knockout of ?-III spectrin in which ataxia and progressive degeneration of cerebellar Purkinje cells has been previously reported and found morphological abnormalities in neurons from prefrontal cortex and deficits in object recognition tasks, consistent with the human cognitive phenotype. These data provide the first evidence that ?-III spectrin plays an important role in cortical brain development and cognition, in addition to its function in the cerebellum; and we conclude that cognitive impairment is an integral part of this novel recessive ataxic syndrome, Spectrin-associated Autosomal Recessive Cerebellar Ataxia type 1 (SPARCA1). In addition, the identification of SPARCA1 and normal heterozygous carriers of the stop codon in SPTBN2 provides insights into the mechanism of molecular dominance in SCA5 and demonstrates that the cell-specific repertoire of spectrin subunits underlies a novel group of disorders, the neuronal spectrinopathies, which includes SCA5, SPARCA1, and a form of West syndrome. PMID:23236289

Lise, Stefano; Clarkson, Yvonne; Perkins, Emma; Kwasniewska, Alexandra; Sadighi Akha, Elham; Schnekenberg, Ricardo Parolin; Suminaite, Daumante; Hope, Jilly; Baker, Ian; Gregory, Lorna; Green, Angie; Allan, Chris; Lamble, Sarah; Jayawant, Sandeep; Quaghebeur, Gerardine; Cader, M Zameel; Hughes, Sarah; Armstrong, Richard J E; Kanapin, Alexander; Rimmer, Andrew; Lunter, Gerton; Mathieson, Iain; Cazier, Jean-Baptiste; Buck, David; Taylor, Jenny C; Bentley, David; McVean, Gilean; Donnelly, Peter; Knight, Samantha J L; Jackson, Mandy; Ragoussis, Jiannis; Németh, Andrea H

2012-01-01

422

Climatic and basin factors affecting the flood frequency curve: PART II - A full sensitivity analysis based on the continuous simulation approach combined with a factorial experimental design  

NASA Astrophysics Data System (ADS)

The sensitivity analysis described in Hashemi et al. (2000) is based on one-at-a-time perturbations to the model parameters. This type of analysis cannot highlight the presence of parameter interactions which might indeed affect the characteristics of the flood frequency curve (ffc) even more than the individual parameters. For this reason, the effects of the parameters of the rainfall, rainfall runoff models and of the potential evapotranspiration demand on the ffc are investigated here through an analysis of the results obtained from a factorial experimental design, where all the parameters are allowed to vary simultaneously. This latter, more complex, analysis confirms the results obtained in Hashemi et al. (2000) thus making the conclusions drawn there of wider validity and not related strictly to the reference set selected. However, it is shown that two-factor interactions are present not only between different pairs of parameters of an individual model, but also between pairs of parameters of different models, such as rainfall and rainfall-runoff models, thus demonstrating the complex interaction between climate and basin characteristics affecting the ffc and in particular its curvature. Furthermore, the wider range of climatic regime behaviour produced within the factorial experimental design shows that the probability distribution of soil moisture content at the storm arrival time is no longer sufficient to explain the link between the perturbations to the parameters and their effects on the ffc, as was suggested in Hashemi et al. (2000). Other factors have to be considered, such as the probability distribution of the soil moisture capacity, and the rainfall regime, expressed through the annual maximum rainfalls over different durations.

Franchini, M.; Hashemi, A. M.; O'Connell, P. E.

423

Endovascular image-guided treatment of in-vivo model aneurysms with asymmetric vascular stents (AVS): evaluation with time-density curve angiographic analysis and histology  

NASA Astrophysics Data System (ADS)

In this study, we compare the results obtained from Time-Density Curve (TDC) analysis of angiographic imaging sequences with histological evaluation for a rabbit aneurysm model treated with standard stents and new asymmetric vascular stents (AVS) placed by image-guided endovascular deployment. AVSs are stents having a low-porosity patch region designed to cover the aneurysm neck and occlude blood flow inside. To evaluate the AVSs, rabbits with elastase-induced aneurysm models (n=20) were divided into three groups: the first (n=10) was treated with an AVS, the second (n=5) with a non-patch standard coronary stent, and third was untreated as a control (n=5). We used TDC analysis to measure how much contrast media entered the aneurysm before and after treatment. TDCs track contrast-media-density changes as a function of time over the region of interest in x-ray DSA cine-sequences. After 28 days, the animals were sacrificed and the explanted specimens were histologically evaluated. The first group showed an average reduction of contrast flow into the aneurysm of 95% after treatment with an AVS with fully developed thrombus at 28 days follow-up. The rabbits treated with standard stents showed an increase in TDC residency time after treatment and partial-thrombogenesis. The untreated control aneurysms displayed no reduction in flow and were still patent at follow-up. The quantitative TDC analysis findings were confirmed by histological evaluation suggesting that the new AVS has great potential as a definitive treatment for cerebro-vascular aneurysms and that angiographic TDC analysis can provide in-vivo verification.

Dohatcu, A.; Ionita, C. N.; Paciorek, A.; Bednarek, D. R.; Hoffmann, K. R.; Rudin, S.

2008-03-01

424

Multivariate Curve Resolution Analysis for Interpretation of Dynamic Cu K-Edge X-ray Absorption Spectroscopy Spectra for a Cu Doped V2O5 Lithium Battery  

SciTech Connect

Vanadium pentoxide materials prepared through sol-gel processes act as excellent intercalation hosts for lithium as well as polyvalent cations. A chemometric approach has been applied to study the X-ray absorption near-edge structure (XANES) evolution during in situ scanning of the Cu{sub 0.1}V{sub 2}O{sub 5} xerogel/Li ions battery. Among the more common techniques, the fixed size windows evolving factor analysis (FSWEFA) permits the number of species involved in the experiment to be determined and the range of existence of each of them. This result, combined with the constraints of the invariance of the total concentration and non-negativity of both concentrations and spectra, enabled us to obtain the spectra of the pure components using a multivariate curve resolution refined by an alternate least squares fitting procedure. This allowed the normalized concentration profile to be understood. This data treatment evidenced the occurrence, for the first time, of three species during the battery charging. This fact finds confirmation by comparison of the pure spectra with the experimental ones. Extended X-ray absorption fine structure (EXAFS) analysis confirms the occurrence of three different chemical environments of Cu during battery charging.

Conti, P.; Zamponi, S; Giorgetti, M; Berrettoni, M; Smyrl, W

2010-01-01

425

Chemometric processing of second-order liquid chromatographic data with UV-vis and fluorescence detection. A comparison of multivariate curve resolution and parallel factor analysis 2.  

PubMed

Second-order liquid chromatographic data with multivariate spectral (UV-vis or fluorescence) detection usually show changes in elution time profiles from sample to sample, causing a loss of trilinearity in the data. In order to analyze them with an appropriate model, the latter should permit a given component to have different time profiles in different samples. Two popular models in this regard are multivariate curve resolution-alternating least-squares (MCR-ALS) and parallel factor analysis 2 (PARAFAC2). The conditions to be fulfilled for successful application of the latter model are discussed on the basis of simple chromatographic concepts. An exhaustive analysis of the multivariate calibration models is carried out, employing both simulated and experimental chromatographic data sets. The latter involve the quantitation of benzimidazolic and carbamate pesticides in fruit and juice samples using liquid chromatography with diode array detection, and of polycyclic aromatic hydrocarbons in water samples, in both cases in the presence of potential interferents using liquid chromatography with fluorescence spectral detection, thereby achieving the second-order advantage. The overall results seem to favor MCR-ALS over PARAFAC2, especially in the presence of potential interferents. PMID:25127646

Bortolato, Santiago A; Olivieri, Alejandro C

2014-09-01

426

Diencephalic-mesencephalic junction dysplasia: a novel recessive brain malformation.  

PubMed

We describe six cases from three unrelated consanguineous Egyptian families with a novel characteristic brain malformation at the level of the diencephalic-mesencephalic junction. Brain magnetic resonance imaging demonstrated a dysplasia of the diencephalic-mesencephalic junction with a characteristic 'butterfly'-like contour of the midbrain on axial sections. Additional imaging features included variable degrees of supratentorial ventricular dilatation and hypoplasia to complete agenesis of the corpus callosum. Diffusion tensor imaging showed diffuse hypomyelination and lack of an identifiable corticospinal tract. All patients displayed severe cognitive impairment, post-natal progressive microcephaly, axial hypotonia, spastic quadriparesis and seizures. Autistic features were noted in older cases. Talipes equinovarus, non-obstructive cardiomyopathy and persistent hyperplastic primary vitreous were additional findings in two families. One of the patients required shunting for hydrocephalus; however, this yielded no change in ventricular size suggestive of dysplasia rather than obstruction. We propose the term 'diencephalic-mesencephalic junction dysplasia' to characterize this autosomal recessive malformation. PMID:22822038

Zaki, Maha S; Saleem, Sahar N; Dobyns, William B; Barkovich, A James; Bartsch, Hauke; Dale, Anders M; Ashtari, Manzar; Akizu, Naiara; Gleeson, Joseph G; Grijalvo-Perez, Ana Maria

2012-08-01

427

Molecular and Cellular Basis of Autosomal Recessive Primary Microcephaly  

PubMed Central

Autosomal recessive primary microcephaly (MCPH) is a rare hereditary neurodevelopmental disorder characterized by a marked reduction in brain size and intellectual disability. MCPH is genetically heterogeneous and can exhibit additional clinical features that overlap with related disorders including Seckel syndrome, Meier-Gorlin syndrome, and microcephalic osteodysplastic dwarfism. In this review, we discuss the key proteins mutated in MCPH. To date, MCPH-causing mutations have been identified in twelve different genes, many of which encode proteins that are involved in cell cycle regulation or are present at the centrosome, an organelle crucial for mitotic spindle assembly and cell division. We highlight recent findings on MCPH proteins with regard to their role in cell cycle progression, centrosome function, and early brain development. PMID:25548773

2014-01-01

428

Germinal mosaicism for LMNA mimics autosomal recessive congenital muscular dystrophy.  

PubMed

Life-threatening cardiac and respiratory complications are common in LMNA-related myopathies and early diagnosis is important for optimal patient care. Lamin A/C related congenital muscular dystrophy (L-CMD) is often caused by de novo mutation in LMNA, affecting a single child in a family. Germinal mosaicism is a rarer variant that can lead to two children inheriting the same new heterozygous mutation from a clinically unaffected parent. Both patterns mimic autosomal recessive (AR) inheritance and the possibility of de novo L-CMD may be forgotten since most causes of congenital muscular dystrophy follow AR inheritance. To illustrate the challenge of diagnosing L-CMD, we present a consanguineous family in which two children have early onset LMNA-related myopathy likely due to paternal germinal mosaicism. This emphasises that germinal mosaicism (and de novo mutations) for LMNA can arise in any family and direct gene sequencing is required to confirm or exclude the diagnosis. PMID:19084400

Makri, Samira; Clarke, Nigel F; Richard, Pascale; Maugenre, Svetlana; Demay, Laurence; Bonne, Gisèle; Guicheney, Pascale

2009-01-01

429

Diencephalic–mesencephalic junction dysplasia: a novel recessive brain malformation  

PubMed Central

We describe six cases from three unrelated consanguineous Egyptian families with a novel characteristic brain malformation at the level of the diencephalic–mesencephalic junction. Brain magnetic resonance imaging demonstrated a dysplasia of the diencephalic–mesencephalic junction with a characteristic ‘butterfly’-like contour of the midbrain on axial sections. Additional imaging features included variable degrees of supratentorial ventricular dilatation and hypoplasia to complete agenesis of the corpus callosum. Diffusion tensor imaging showed diffuse hypomyelination and lack of an identifiable corticospinal tract. All patients displayed severe cognitive impairment, post-natal progressive microcephaly, axial hypotonia, spastic quadriparesis and seizures. Autistic features were noted in older cases. Talipes equinovarus, non-obstructive cardiomyopathy and persistent hyperplastic primary vitreous were additional findings in two families. One of the patients required shunting for hydrocephalus; however, this yielded no change in ventricular size suggestive of dysplasia rather than obstruction. We propose the term ‘diencephalic–mesencephalic junction dysplasia’ to characterize this autosomal recessive malformation. PMID:22822038

Saleem, Sahar N.; Dobyns, William B.; Barkovich, A. James; Bartsch, Hauke; Dale, Anders M.; Ashtari, Manzar; Akizu, Naiara; Gleeson, Joseph G.; Grijalvo-Perez, Ana Maria

2012-01-01

430

Operating temperatures for a convectively cooled recessed incandescent light fixture  

SciTech Connect

Test results are given for the operation of a recessed incandescent light fixture intended for residential use. The fixture is labeled for use in direct contact with attic thermal insulation. Temperature control of the powered fixture is provided by convective heat transfer from the ceiling side of the fixture. The fixture was operated at power levels up to two times the rated power of 75 watts and under thermal insulations up to R-40. In all operating configurations tested the fixture surface in contact with attic insulation was found to be less than 175/sup 0/C. The observed surface temperatures are judged to be safe for operation in contact with loose-fill or batt-type insulations. It was observed that the power leads inside one fixture configuration are exposed to temperatures as high as 168/sup 0/C. The electrical insulation could, therefore, have a limited life. The properties of the internal fixture wiring were not, however, studied in detail.

Yarbrough, D.W.; Toor, I.

1980-12-01

431

Parallel Curves: Getting There and Getting Back  

ERIC Educational Resources Information Center

This note takes up the issue of parallel curves while illustrating the utility of "Mathematica" in computations. This work complements results presented earlier. The presented treatment, considering the more general case of parametric curves, provides an analysis of the appearance of cusp singularities, and emphasizes the utility of symbolic…

Agnew, A. F.; Mathews, J. H.

2006-01-01

432

Weathering the Storm: Generating Revenues for Higher Education during a Recession.  

ERIC Educational Resources Information Center

Reviews some recent financial trends in higher education and provides a brief overview of the current recession in the United States. Offers some views on how this recession might affect the major revenue sources that institutions of higher education rely on to fund their operations. (SLD)

Toutkoushian, Robert K.

2003-01-01

433

The State of Play: Gallup Survey of Principals on School Recess  

ERIC Educational Resources Information Center

When most people talk about how to improve education, they tend to focus only on what happens in the classroom. But the most unexpected opportunity to boost learning lies outside the classroom: on the playground at recess. A new, first-of-its-kind Gallup poll reveals that elementary school principals overwhelmingly believe recess has a positive…

Robert Wood Johnson Foundation, 2010

2010-01-01