Sample records for recession curve analysis

  1. Comparative analysis of base flow recession curves for different Andean catchments

    NASA Astrophysics Data System (ADS)

    Guzman, P.; Batelaan, O.; Wyseure, G.

    2012-04-01

    Little is known in the Paute River basin, Ecuador about the groundwater resources, the relation between aquifers and their recharge zones and interaction with rivers. The pressure from human activities in the river basin is increasing and impacting the surface water quality and quantity, therefore it becomes increasingly useful to estimate the potential of groundwater exploitation as an alternative resource. Due to the lack of specific groundwater data and information, assessment of suitable alternative methods for groundwater research at different scales is considered. In low flow hydrology literature it is noted that the majority of natural gains to streamflow during low-flow periods are derived from releases from groundwater storage, moreover baseflow is generally suggested to be an indicator of groundwater or other delayed sources. Analysis of flow recession curves allows the determination of characteristics of the groundwater reservoir, which is a prerequisite for the separation of baseflow from total discharge and the estimation of groundwater storage and recharge. The flow recession curve at a river cross section is defined as the discharge hydrograph of the basin during a rainless or dry period. Its analysis yields information on the retention characteristics of the basin and of groundwater storage and depletion. In the Paute River basin baseflows are assumed to be originating from Paramo storage, which is largely determined by the high water retention capacity of the soils in combination with their slopes. In the case of the sub-catchment of the Tarqui River, there are evidences based on topography, hydromorphology, discharges and soils that suggest the presence of a major aquifer in the valley. Hence, the goal of this contribution is the comparison and analysis of groundwater conditions based on baseflow recession analysis for the Tarqui and Yanuncay River sub-catchments. Baseflow analyses are translated in recharge and groundwater resources characteristics, as well as relationships with land cover, morphology, geology and rainfall are established and presented. The results are discussed within the framework of increasing pressures on the water system.

  2. Regionalization of subsurface stormflow parameters of hydrologic models: Derivation from regional analysis of streamflow recession curves

    SciTech Connect

    Ye, Sheng; Li, Hongyi; Huang, Maoyi; Ali, Melkamu; Leng, Guoyong; Leung, Lai-Yung R.; Wang, Shaowen; Sivapalan, Murugesu

    2014-07-21

    Subsurface stormflow is an important component of the rainfall–runoff response, especially in steep terrain. Its contribution to total runoff is, however, poorly represented in the current generation of land surface models. The lack of physical basis of these common parameterizations precludes a priori estimation of the stormflow (i.e. without calibration), which is a major drawback for prediction in ungauged basins, or for use in global land surface models. This paper is aimed at deriving regionalized parameterizations of the storage–discharge relationship relating to subsurface stormflow from a top–down empirical data analysis of streamflow recession curves extracted from 50 eastern United States catchments. Detailed regression analyses were performed between parameters of the empirical storage–discharge relationships and the controlling climate, soil and topographic characteristics. The regression analyses performed on empirical recession curves at catchment scale indicated that the coefficient of the power-law form storage–discharge relationship is closely related to the catchment hydrologic characteristics, which is consistent with the hydraulic theory derived mainly at the hillslope scale. As for the exponent, besides the role of field scale soil hydraulic properties as suggested by hydraulic theory, it is found to be more strongly affected by climate (aridity) at the catchment scale. At a fundamental level these results point to the need for more detailed exploration of the co-dependence of soil, vegetation and topography with climate.

  3. Objective hydrograph baseflow recession analysis

    NASA Astrophysics Data System (ADS)

    Thomas, Brian F.; Vogel, Richard M.; Famiglietti, James S.

    2015-06-01

    A streamflow hydrograph recession curve expresses the theoretical relationship between aquifer structure and groundwater outflow to a stream channel. That theoretical relationship is often portrayed empirically using a recession plot defined as a plot of ln(-dQ/dt) versus ln(Q), where Q is streamflow discharge. Such hydrograph recession plots are commonly used to estimate recession parameters, aquifer properties and for evaluating alternative hydrologic hypotheses. We introduce a comprehensive and objective approach to analyze baseflow recessions with innovations including the use of quantile regression, efficient and objective numerical estimation of dQ/dt, inclusion of groundwater withdrawals, and incorporation of seasonal effects. We document that these innovations when all combined, lead to significant improvements, over previous studies, in our ability to discern the theoretical behavior of stream aquifer systems. A case study reveals that our methodology enables us to reject the simple linear reservoir hypothesis of stream aquifer interactions for watersheds in New Jersey and results in improved correlations between low flow statistics and aquifer properties for those same watersheds.

  4. Synthesis of streamflow recession curves in dry environments

    NASA Astrophysics Data System (ADS)

    Arciniega, Saul; Breña-Naranjo, Agustín; Pedrozo-Acuña, Adrían

    2015-04-01

    The elucidation and predictability of hydrological systems can largely benefit by extracting observed patterns in processes, data and models. Such type of research framework in hydrology, also known as synthesis has gained significant attention over the last decade. For instance, hydrological synthesis implies that the identification of patterns in catchment behavior can enhance the extrapolation of hydrological signatures over large spatial and temporal scales. Hydrological signatures during dry periods such as streamflow recession curves (SRC) are of special interest in regions coping with water scarcity. Indeed, the study of SRCs from observed hydrographs allows to extract information about the storage-discharge relationship of a specific catchment and some of their groundwater hydraulic properties. This work aims at performing a synthesis work of SRCs in semi-arid & arid environments across Northern Mexico. Our dataset consisted in observed daily SRCs in 63 catchments with minima human interferences. Three streamflow recession extraction methods (Vogel, Brutsaert and Aksoy-Wittenberg) along with four recession models (Maillet, Boussinesq, Coutagne y Wittenberg) and three parameter estimation techniques (regressions, lower envelope y data binning) were used to determine the combination among different possible methods, processes and models that better describes SRCs in our study sites. Our results show that the extraction method proposed by Aksoy-Wittenberg along with Coutagne's nonlinear recession model provides a better approximation of SRCs across Northern Mexico, whereas regression was found to be the most adequate parameter estimation method. This study suggests that hydrological synthesis turned out to be an useful framework to identify similar patterns and model parameters during dry periods across Mexico's water-limited environments.

  5. Fully automated objective-based method for master recession curve separation.

    PubMed

    Posavec, Kristijan; Parlov, Jelena; Naki?, Zoran

    2010-01-01

    The fully automated objective-based method for master recession curve (MRC) separation was developed by using Microsoft Excel spreadsheet and Visual Basic for Applications (VBA) code. The core of the program code is used to construct an MRC by using the adapted matching strip method (Posavec et al. 2006). Criteria for separating the MRC into two or three segments are determined from the flow-duration curve and are represented as the probable range of percent of flow rate duration. Successive separations are performed automatically on two and three MRCs using sets of percent of flow rate duration from selected ranges and an optimal separation model scenario, having the highest average coefficient of determination R(2), is selected as the most appropriate one. The resulting separated master recession curves are presented graphically, whereas the statistics are presented numerically, all in separate sheets. Examples of field data obtained from two springs in Istria, Croatia, are used to illustrate its application. The freely available Excel spreadsheet and VBA program ensures the ease of use and applicability for larger data sets. PMID:20100291

  6. Recession analysis across scales: The impact of both random and nonrandom spatial variability on aggregated hydrologic response

    NASA Astrophysics Data System (ADS)

    Chen, Bo; Krajewski, Witold F.

    2015-04-01

    Recession analysis across scales can provide insight into the spatial aggregation of hydrologic processes. Accordingly, we analyzed individual late-time recession curves from 25 nested USGS stream gauges over a period of ?150 days with negligible precipitation during the 2012-2013 North American drought. These gauges are located in the Iowa and Cedar River basins and drain areas ranging from ?70 to 17,000 km2. Our data analyses show that these late-time recession processes can be represented by a linear reservoir model with a constant recession time scale of about 34 days, indicating linear and homogeneous recession behaviors at the large scales investigated. However, others have shown that the early-time recession process becomes more nonlinear as spatial scale and, thus, spatial variability increases. We developed a distributed drainage model as a diagnostic tool to understand these seemingly contradictory recession characteristics at multiple spatial scales and different stages. With a hierarchical description of the recession variability at the hillslope scale, our model can simultaneously produce the increasing nonlinear early-time and the linear and homogenous late-time recession behaviors at larger scales. The hierarchical representation classifies hillslopes according to the Strahler orders of the stream links into which they drain. We postulate that a larger difference in recession behaviors will occur between hillslopes from different orders than between those from the same order. Overall, this study shows how the spatial randomness and nonrandomness of small-scale process variability control the hydrologic responses at larger scales and suggests a combined (nonrandom-random) representation of watersheds for aggregating hydrologic processes.

  7. Shakedown Analysis of Curved Beams

    Microsoft Academic Search

    F. Tin Lol

    1984-01-01

    Shakedown analysis of fixed-ended elastoplastic curved beams is presented. Both nonlinear and piecewise linearized yield conditions are considered. It is shown that the former assumption requires the solution of a nonlinear programming problem, while the latter assumption leads to a linear programming problem. Although these formulations cover both cases when either incremental collapse or alternating plasticity governs the shakedown limit

  8. Technical Note: A measure of watershed nonlinearity II: re-introducing an IFP inverse fractional power transform for streamflow recession analysis

    NASA Astrophysics Data System (ADS)

    Ding, J. Y.

    2013-12-01

    This note illustrates, in the context of Brutsaert-Nieber (1977) model: -dQ/dt = aQb, the utility of a newly rediscovered inverse fractional power (IFP) transform of the flow rates. This method of streamflow recession analysis dates back a half-century. The IFP transform ?b on an operand Q is defined as ?b Q = 1/Qb-1. Brutsaert-Nieber model by IFP transform thus becomes: ?bQ(t) = ?bQ(0) + (b-1) at, if b ≠ 1. The IFP transformed recession curve appears as a straight line on a semi-IFP plot. The method has both the advantage of being independent of the size of computational time step, and the disadvantage of being depending on the parameter b value. This is used to calibrate the Brutsaert-Nieber recession flow model in which b is a slope (or shape) parameter, and a is an intercept (or a scale parameter). It is applied to four observed events on the Spoon River in Illinois (4237 km2). The results show that the IFP transform method gives a narrower range of parameter b values than the regression method in a recession plot. Theoretically, an IFP transformed recession curve for large watersheds falls between those performed by the reciprocal of the cubic root (RoCR) transform and the reciprocal of the square root (RoSR) one. In general, the forgotten IFP transform method merits a fresh look, especially for hillslopes and zero-order catchments, the building blocks of a watershed system. In particular, because of its origin in hillslope hydrology, the 1-parameter RoSR transform need be falsified or verified for application to headwater catchments.

  9. Decline curve analysis for horizontal wells

    E-print Network

    Shih, Min-Yu

    1994-01-01

    , Page vi vii CHAPTER 11 - THEORETICAL MODEL FOR A HORIZONTAL WELL. . . . . . . . . . . . . . . . 7 2. 1 Description, Assumptions, and Solution of the Horizontal Well Model . . . . . . 8 2. 2 Pseudoskin Function for Horizontal Well. 12 2. 3 Flow... III - DEVELOPMENT OF NEW TYPE CURVES FOR AN INFINITE-CONDUCTIVITY HORIZONTAL WELL MODEL . . . , . . . 31 3. 1 The Arps Empirical Equations for Decline Curve Analysis . . . . . . . . . ?. .. . . . . . . . . . . . 31 3, 2 Development of the Plotting...

  10. Wavelet Analysis of Galactic Rotation Curves

    E-print Network

    Kuassivi, M

    2011-01-01

    The spatial wavelet spectra of 73 published spiral galaxies's rotation curves are computed and their associated scaleograms are presented. Scaleograms are used to detect and isolate local features observed in spiral galaxies's rotation curves. Although wiggles and bumps are usually interpreted as signs of recent and on-going merging, the analysis of the scaleograms reveals regular patterns consistent with the presence of large-scale modes throughout the disk.

  11. Enjoying Recess.

    ERIC Educational Resources Information Center

    Corbin, C. B., Ed.

    1979-01-01

    Guidelines are offered to help make recess a more enjoyable and beneficial experience for all children. Physical educators may have to supervise inservice programs for other school personnel in this area. (JMF)

  12. Molecular and phenotypic analysis of 25 recessive, homozygous-viable alleles at the mouse agouti locus.

    PubMed

    Miltenberger, Rosalynn J; Wakamatsu, Kazumasa; Ito, Shosuke; Woychik, Richard P; Russell, Liane B; Michaud, Edward J

    2002-02-01

    Agouti is a paracrine-acting, transient antagonist of melanocortin 1 receptors that specifies the subapical band of yellow on otherwise black hairs of the wild-type coat. To better understand both agouti structure/function and the germline damage caused by chemicals and radiation, an allelic series of 25 recessive, homozygous-viable agouti mutations generated in specific-locus tests were characterized. Visual inspection of fur, augmented by quantifiable chemical analysis of hair melanins, suggested four phenotypic categories (mild, moderate, umbrous-like, severe) for the 18 hypomorphs and a single category for the 7 amorphs (null). Molecular analysis indicated protein-coding alterations in 8 hypomorphs and 6 amorphs, with mild-moderate phenotypes correlating with signal peptide or basic domain mutations, and more devastating phenotypes resulting from C-terminal lesions. Ten hypomorphs and one null demonstrated wild-type coding potential, suggesting that they contain mutations elsewhere in the > or = 125-kb agouti locus that either reduce the level or alter the temporal/spatial distribution of agouti transcripts. Beyond the notable contributions to the field of mouse germ cell mutagenesis, analysis of this allelic series illustrates that complete abrogation of agouti function in vivo occurs most often through protein-coding lesions, whereas partial loss of function occurs slightly more frequently at the level of gene expression control. PMID:11861569

  13. Molecular and phenotypic analysis of 25 recessive, homozygous-viable alleles at the mouse agouti locus.

    PubMed Central

    Miltenberger, Rosalynn J; Wakamatsu, Kazumasa; Ito, Shosuke; Woychik, Richard P; Russell, Liane B; Michaud, Edward J

    2002-01-01

    Agouti is a paracrine-acting, transient antagonist of melanocortin 1 receptors that specifies the subapical band of yellow on otherwise black hairs of the wild-type coat. To better understand both agouti structure/function and the germline damage caused by chemicals and radiation, an allelic series of 25 recessive, homozygous-viable agouti mutations generated in specific-locus tests were characterized. Visual inspection of fur, augmented by quantifiable chemical analysis of hair melanins, suggested four phenotypic categories (mild, moderate, umbrous-like, severe) for the 18 hypomorphs and a single category for the 7 amorphs (null). Molecular analysis indicated protein-coding alterations in 8 hypomorphs and 6 amorphs, with mild-moderate phenotypes correlating with signal peptide or basic domain mutations, and more devastating phenotypes resulting from C-terminal lesions. Ten hypomorphs and one null demonstrated wild-type coding potential, suggesting that they contain mutations elsewhere in the > or = 125-kb agouti locus that either reduce the level or alter the temporal/spatial distribution of agouti transcripts. Beyond the notable contributions to the field of mouse germ cell mutagenesis, analysis of this allelic series illustrates that complete abrogation of agouti function in vivo occurs most often through protein-coding lesions, whereas partial loss of function occurs slightly more frequently at the level of gene expression control. PMID:11861569

  14. ARMA Analysis of APT Light Curves

    NASA Astrophysics Data System (ADS)

    Nelson, E. R.

    Autoregressive Moving Average (ARMA) time series analysis, combined with a modified form of a linear Kalman filter, has been found to be a useful method for extracting trends and seasonal patterns in the data. UBV light curves for 3 sources (HK Lac, ? Gem and 93 Leo), observed with the Fairborn Observatories APT, were digitized with the Kalman filter and ARMA (n, n-1) models were fit to the redistributed data for n ranging from 2 to 4.

  15. Evaluating knickpoint recession along an active fault for paleoseismological analysis: The Huoshan Piedmont, Eastern China

    NASA Astrophysics Data System (ADS)

    Wei, Zhanyu; Bi, Lisi; Xu, Yueren; He, Honglin

    2015-04-01

    Ground-rupturing earthquakes can generate tectonic knickpoints within upstream reaches of streams across active fault zones. These knickpoints are characteristic of upstream propagation of time-related process once generated by an earthquake, so analysis of knickpoint series in streams which cross fault zones can be used to infer paleoearthquake events. We studied the knickpoints along the Huoshan Piedmont Fault (HPF), which is an active normal fault in the Shanxi Faulted Basin zone, China, and demonstrate that analysis of knickpoints shows evidence for two paleoearthquakes in the HPF. First, we identified knickpoints in bedrock reaches upstream of the HPF using high-resolution DEMs derived from IRS-P5 stereo images and the stream-gradient method. After excluding non-faulting knickpoints, 47 knickpoints were identified in 23 bedrock reaches upstream from the HPF. Analysis of the most recent knickpoints caused by the 1303 CE Hongdong Earthquake allowed for local calibration of the retreat rates. Applying these retreat rates across the study area allows for the estimation of the age of other knickpoints, and constrains the age ranges of two knickpoint groups to be 2269-3336 a BP and 4504-5618 a BP. These ages constrain the ages of two paleoearthquake events at 2710 ± 102 and 4980 ± 646 a BP. The knickpoints along the HPF obey the parallel retreating model in which knickpoint morphology was roughly maintained during retreat, so the heights of knickpoints represent the coseismic vertical displacements generated by the earthquakes along the HPF. The vertical offsets for these three earthquake events are similar and are approximately 4 m, which indicates that the ruptures on the HPF obey a characteristic slip model with a similar slip distribution for several successive earthquakes. These results provide additional evidence of paleoearthquakes on the HPF and show that analysis of knickpoint recession along an active fault is a valuable tool for paleoseismology.

  16. Determination of Radiation-induced Mutation Rates of Recessive Lethal Alleles in Saccharomyces

    Microsoft Academic Search

    W. Laskowski; K. Haefner

    1963-01-01

    COMPARING X-ray inactivation curves of haploid and diploid strains of Saccharomyces, Latarjet and Ephrussi1 were the first to suggest that radiation inactivation of yeast cells may be caused by an induction of recessive and dominant lethal mutations. The first evidence of X-ray-induced recessive and dominant lethal mutations was obtained by Mortimer2 by means of tetrad analysis and specific mating experiments

  17. Genetic analysis of autosomal recessive osteopetrosis in Chuvashiya: the unique splice site mutation in TCIRG1 gene spread by the founder effect

    PubMed Central

    Bliznetz, Elena A; Tverskaya, Svetlana M; Zinchenko, Rena A; Abrukova, Anna V; Savaskina, Ekaterina N; Nikulin, Maxim V; Kirillov, Alexander G; Ginter, Evgeny K; Polyakov, Alexander V

    2009-01-01

    The rare malignant disorder autosomal recessive osteopetrosis (OPTB) is one of the most prevalent autosomal recessive diseases in the Chuvash Republic of Russia. The purpose of this study was to determine the underlying molecular cause of osteopetrosis in Chuvashiya and to reveal the factors causing the unusual high frequency of the disease in this region. Having assumed a founder effect, we performed linkage disequilibrium (LD) mapping of the OPTB locus at the TCIRG1 region and found a unique splice site mutation c.807+5G>A in all Chuvashian OPTB patients studied. We then analyzed the mutational change in mRNA and detected an intron insertion within the mutant transcript, resulting in a frameshift and premature stop-codon formation (p.Leu271AspfsX231). A decreased expression of the mutant transcript was also detected, which may have been the result of nonsense-mediated decay. Real-time qPCR and MLPA® melting curve analysis-based systems were designed and used for c.807+5G>A mutation screening. In addition to analyzing the gene frequency in Chuvashiya, we also estimated three other populations in the Volga-Ural region (Mari, Udmurt and Bashkir). We found a 1.68% prevalence in Chuvashiya (calculated disease frequency, 1/3500 newborns) and a 0.84% in the Mari population (1/14?000 newborns). The haplotype analysis revealed that all OPTB cases in Chuvashians and Marians originated from a single mutational event and the age of the mutation in Chuvashians was estimated to be approximately 890 years. PMID:19172990

  18. Gastrocnemius recession.

    PubMed

    Anderson, John G; Bohay, Donald R; Eller, Erik B; Witt, Bryan L

    2014-12-01

    The Grand Rapids Arch Collapse classifications create a novel system for categorizing and correlating numerous common foot and ankle conditions related to a falling arch. The algorithm for treating these conditions is exceptionally replicable and has excellent outcomes. Gastrocnemius equinus diagnosis plays a crucial role in the pathology of arch collapse. A contracture of the gastrocnemius muscle is increasingly recognized as the cause of several foot and ankle conditions. The authors have expanded their indications for gastrocnemius recession to include arch pain without radiographic abnormality, calcaneus apophysitis, plantar fasciitis/fibromas, Achilles tendonosis, early-onset diabetic Charcot arthropathy, and neuropathic forefoot ulcers. PMID:25456721

  19. Physiological response curve analysis using nonlinear mixed models

    Microsoft Academic Search

    Michael S. Peek; Estelle Russek-Cohen; Alexander D. Wait; Irwin N. Forseth

    2002-01-01

    Nonlinear response curves are often used to model the physiological responses of plants. These models are preferable to polynomials because the coefficients fit to the curves have biological meaning. The response curves are often generated by repeated measurements on one subject, over a range of values for the environmental variable of interest. However, the typical analysis of differences in coefficients

  20. Statistical Analysis of Single-Molecule AFM Force Spectroscopy Curves

    E-print Network

    Schmidler, Scott

    Statistical Analysis of Single-Molecule AFM Force Spectroscopy Curves Alexei Valiaev1,2 , Stefan-extension curves obtained from single-molecule force spectroscopy (SMFS) measurements. We apply this methodology. The force-extension curves of such molecules are often well described by statistical mechanical polymer

  1. Analysis of exome sequence in 604 trios for recessive genotypes in schizophrenia.

    PubMed

    Rees, E; Kirov, G; Walters, J T; Richards, A L; Howrigan, D; Kavanagh, D H; Pocklington, A J; Fromer, M; Ruderfer, D M; Georgieva, L; Carrera, N; Gormley, P; Palta, P; Williams, H; Dwyer, S; Johnson, J S; Roussos, P; Barker, D D; Banks, E; Milanova, V; Rose, S A; Chambert, K; Mahajan, M; Scolnick, E M; Moran, J L; Tsuang, M T; Glatt, S J; Chen, W J; Hwu, H-G; Neale, B M; Palotie, A; Sklar, P; Purcell, S M; McCarroll, S A; Holmans, P; Owen, M J; O'Donovan, M C

    2015-01-01

    Genetic associations involving both rare and common alleles have been reported for schizophrenia but there have been no systematic scans for rare recessive genotypes using fully phased trio data. Here, we use exome sequencing in 604 schizophrenia proband-parent trios to investigate the role of recessive (homozygous or compound heterozygous) nonsynonymous genotypes in the disorder. The burden of recessive genotypes was not significantly increased in probands at either a genome-wide level or in any individual gene after adjustment for multiple testing. At a system level, probands had an excess of nonsynonymous compound heterozygous genotypes (minor allele frequency, MAF ?1%) in voltage-gated sodium channels (VGSCs; eight in probands and none in parents, P=1.5 × 10(-)(4)). Previous findings of multiple de novo loss-of-function mutations in this gene family, particularly SCN2A, in autism and intellectual disability provide biological and genetic plausibility for this finding. Pointing further to the involvement of VGSCs in schizophrenia, we found that these genes were enriched for nonsynonymous mutations (MAF ?0.1%) in cases genotyped using an exome array, (5585 schizophrenia cases and 8103 controls), and that in the trios data, synaptic proteins interacting with VGSCs were also enriched for both compound heterozygosity (P=0.018) and de novo mutations (P=0.04). However, we were unable to replicate the specific association with compound heterozygosity at VGSCs in an independent sample of Taiwanese schizophrenia trios (N=614). We conclude that recessive genotypes do not appear to make a substantial contribution to schizophrenia at a genome-wide level. Although multiple lines of evidence, including several from this study, suggest that rare mutations in VGSCs contribute to the disorder, in the absence of replication of the original findings regarding compound heterozygosity, this conclusion requires evaluation in a larger sample of trios. PMID:26196440

  2. Functional analysis of FOXE3 mutations causing dominant and recessive ocular anterior segment disease.

    PubMed

    Islam, Lily; Kelberman, Daniel; Williamson, Laura; Lewis, Nicola; Glindzicz, Maria Bitner; Nischal, Ken K; Sowden, Jane C

    2015-03-01

    Mutations in FOXE3 are associated with both recessive and dominant inheritance of severe anterior ocular malformations and glaucoma. However, functional analyses of putative pathogenic mutations have not been performed. We tested the hypothesis that variations in FOXE3 activity underlie the different modes of inheritance and disease phenotype. In band shift assays, three recessive mutants showed loss-of-function, one retained DNA binding activity, whereas two dominant mutants showed altered activity. All six mutants showed reduced transactivation function compared with wild-type, and modeling the heterozygous state resulted in an intermediate level of activity providing no evidence for dominant negative action. Our in vitro data are consistent with loss-of-function below a dosage sensitive threshold as a mechanism of action for recessive mutations, but indicate an altered mutant protein function rather than a haploinsufficient mechanism for dominant mutations. This study provides the first functional evidence demonstrating that FOXE3 mutations identified in patients impair protein function with differential effects. PMID:25504734

  3. Time delay analysis in high speed gate-recessed E-mode InAlN HEMTs

    NASA Astrophysics Data System (ADS)

    Sensale-Rodriguez, Berardi; Guo, Jia; Wang, Ronghua; Verma, Jai; Li, Guowang; Fang, Tian; Beam, Edward; Ketterson, Andrew; Schuette, Michael; Saunier, Paul; Gao, Xiang; Guo, Shiping; Snider, Gregory; Fay, Patrick; Jena, Debdeep; Xing, Huili Grace

    2013-02-01

    Delay analysis providing an alternative physical explanation on carrier transport, which may be more applicable to high electron mobility transistor (HEMT) channels with moderate carrier mobilities, has been applied to enhancement-mode (E-mode) and depletion-mode (D-mode) InAlN/AlN/GaN HEMTs with comparable fT at room and cryogenic temperatures. It was found that the speed of the E-mode HEMTs with 33-nm long T-gate is dominated by parasitic delays, >40% of the total delay; channel mobility might have degraded due to gate recess.

  4. Type-curve analysis: What it can and cannot do

    SciTech Connect

    Gringarten, A.C.

    1987-01-01

    Type-curve analysis has been used for more than 20 years in the oil industry and for more than 40 years in hydrogeology. Yet, what it involves and how useful it is in practice is still being debated within the oil industry. This paper attempts to answer some of the questions that are most commonly raised about type curves and type-curve analysis.

  5. Replication and Analysis of Ebbinghaus’ Forgetting Curve

    PubMed Central

    Murre, Jaap M. J.; Dros, Joeri

    2015-01-01

    We present a successful replication of Ebbinghaus’ classic forgetting curve from 1880 based on the method of savings. One subject spent 70 hours learning lists and relearning them after 20 min, 1 hour, 9 hours, 1 day, 2 days, or 31 days. The results are similar to Ebbinghaus' original data. We analyze the effects of serial position on forgetting and investigate what mathematical equations present a good fit to the Ebbinghaus forgetting curve and its replications. We conclude that the Ebbinghaus forgetting curve has indeed been replicated and that it is not completely smooth but most probably shows a jump upwards starting at the 24 hour data point. PMID:26148023

  6. Curving Analysis of Modified Designs of Passenger Railway Vehicle Trucks

    Microsoft Academic Search

    Rao V. Dukkipati; Srinivasan Narayanaswamy; Mohammad O. M. Osman

    2002-01-01

    In this paper, modified truck designs were studied with an objective to achieving better compatibility between high speed stability and curving behaviour compared to the conventional truck. The analysis has shown that USD truck can be designed to achieve better over all performance compared to other truck designs. The results of steady state curving program were validated using the commercial

  7. Analysis of exponential decay curves of mixtures

    E-print Network

    McGaughey, Robert Lee

    1967-01-01

    . Tommy Cobb who kept me on the straight and narrow during those first few trying weeks, and to Richard "Hoot" Gibson for his help with LP/90. TABLE OF CONTENTS Acknowledgments List of Tables CHAPTER Page lil Introduction III IV Linear... INTRODUCTION The object of this research was to determine the efficiency and accuracy of a method of analyzing exponential decay curves of radio- active mixtures by applying linear programming solutions to Prony's method. This research is an extension of a...

  8. Comprehensive clinical and molecular analysis of 12 families with type 1 recessive cutis laxa.

    PubMed

    Callewaert, Bert; Su, Chi-Ting; Van Damme, Tim; Vlummens, Philip; Malfait, Fransiska; Vanakker, Olivier; Schulz, Bianca; Mac Neal, Meghan; Davis, Elaine C; Lee, Joseph G H; Salhi, Aicha; Unger, Sheila; Heimdal, Ketil; De Almeida, Salome; Kornak, Uwe; Gaspar, Harald; Bresson, Jean-Luc; Prescott, Katrina; Gosendi, Maria E; Mansour, Sahar; Piérard, Gérald E; Madan-Khetarpal, Suneeta; Sciurba, Frank C; Symoens, Sofie; Coucke, Paul J; Van Maldergem, Lionel; Urban, Zsolt; De Paepe, Anne

    2013-01-01

    Autosomal recessive cutis laxa type I (ARCL type I) is characterized by generalized cutis laxa with pulmonary emphysema and/or vascular complications. Rarely, mutations can be identified in FBLN4 or FBLN5. Recently, LTBP4 mutations have been implicated in a similar phenotype. Studying FBLN4, FBLN5, and LTBP4 in 12 families with ARCL type I, we found bi-allelic FBLN5 mutations in two probands, whereas nine probands harbored biallelic mutations in LTBP4. FBLN5 and LTBP4 mutations cause a very similar phenotype associated with severe pulmonary emphysema, in the absence of vascular tortuosity or aneurysms. Gastrointestinal and genitourinary tract involvement seems to be more severe in patients with LTBP4 mutations. Functional studies showed that most premature termination mutations in LTBP4 result in severely reduced mRNA and protein levels. This correlated with increased transforming growth factor-beta (TGF?) activity. However, one mutation, c.4127dupC, escaped nonsense-mediated decay. The corresponding mutant protein (p.Arg1377Alafs(*) 27) showed reduced colocalization with fibronectin, leading to an abnormal morphology of microfibrils in fibroblast cultures, while retaining normal TGF? activity. We conclude that LTBP4 mutations cause disease through both loss of function and gain of function mechanisms. PMID:22829427

  9. Curving Analysis of Modified Designs of Passenger Railway Vehicle Trucks

    NASA Astrophysics Data System (ADS)

    Dukkipati, Rao V.; Narayanaswamy, Srinivasan; Osman, Mohammad O. M.

    In this paper, modified truck designs were studied with an objective to achieving better compatibility between high speed stability and curving behaviour compared to the conventional truck. The analysis has shown that USD truck can be designed to achieve better over all performance compared to other truck designs. The results of steady state curving program were validated using the commercial software package NUCARS. The comparison of steady state curving behaviour of different truck designs using NUCARS also showed that USD truck has the potential to achieve superior performance compared to other truck designs. The research reported in this paper has dealt with steady state curving behaviour. To look into the safety implications of the new designs, transient behaviour in curves must be studied. The response of the railway cars in entry and exit spirals should be evaluated. The effects of track irregularities on the response of these modified designs need to be analyzed.

  10. Clinical characterization, genetic mapping and whole-genome sequence analysis of a novel autosomal recessive intellectual disability syndrome.

    PubMed

    Kaasinen, Eevi; Rahikkala, Elisa; Koivunen, Peppi; Miettinen, Sirpa; Wamelink, Mirjam M C; Aavikko, Mervi; Palin, Kimmo; Myllyharju, Johanna; Moilanen, Jukka S; Pajunen, Leila; Karhu, Auli; Aaltonen, Lauri A

    2014-10-01

    We identified six patients presenting with a strikingly similar clinical phenotype of profound syndromic intellectual disability of unknown etiology. All patients lived in the same village. Extensive genealogical work revealed that the healthy parents of the patients were all distantly related to a common ancestor from the 17th century, suggesting autosomal recessive inheritance. In addition to intellectual disability, the clinical features included hypotonia, strabismus, difficulty to fix the eyes to an object, planovalgus in the feet, mild contractures in elbow joints, interphalangeal joint hypermobility and coarse facial features that develop gradually during childhood. The clinical phenotype did not fit any known syndrome. Genome-wide SNP genotyping of the patients and genetic mapping revealed the longest shared homozygosity at 3p22.1-3p21.1 encompassing 11.5 Mb, with no other credible candidate loci emerging. Single point parametric linkage analysis showed logarithm of the odds score of 11 for the homozygous region, thus identifying a novel intellectual disability predisposition locus. Whole-genome sequencing of one affected individual pinpointed three genes with potentially protein damaging homozygous sequence changes within the predisposition locus: transketolase (TKT), prolyl 4-hydroxylase transmembrane (P4HTM), and ubiquitin specific peptidase 4 (USP4). The changes were found in heterozygous form with 0.3-0.7% allele frequencies in 402 whole-genome sequenced controls from the north-east of Finland. No homozygotes were found in this nor additional control data sets. Our study facilitates clinical and molecular diagnosis of patients with this novel autosomal recessive intellectual disability syndrome. However, further studies are needed to unambiguously identify the underlying genetic defect. PMID:25078763

  11. Decline curve analysis for double-porosity systems

    SciTech Connect

    Sageev, A.; Da Prat, G.; Moore, J.B.; Ramey, H.J.

    1985-03-01

    A type curve matching method for analyzing constant pressure testing in a double-porosity system is presented. Both infinite systems and closed outer boundary systems are considered. Rate responses of constant pressure wells with and without wellbore skin are described. Five type curves are presented for the rate response of the constant pressure active well. The first four curves describe: An infinite system without wellbore skin, a closed outer boundary system without wellbore skin, an infinite system with wellbore skin, and a closed outer boundary system with wellbore skin. In the fifth type curve, the first four type curves are assembled into one. It is observed that the presence of wellbore skin has an important effect on the rate response of the double-porosity system. It is essential for the success of the analysis, especially in the determination of lambda and /tau//theta/D, to include wellbore skin. The presented analysis method is valid for transient interporosity flow with fracture skin greater than 0.33, with slab-shaped matrix. Three type curve matching examples are presented along with a discussion of the applicability and practicality of the analysis method.

  12. Examining individual recession events instead of a data cloud: Using a modified interpretation of dQ/dt-Q streamflow recession in glaciated watersheds to better inform models of low flow

    NASA Astrophysics Data System (ADS)

    Shaw, Stephen B.; Riha, Susan J.

    2012-04-01

    SummaryTo examine stream recession rates, hydrologists have plotted the rate of change in discharge (dQ/dt) versus the mean discharge (Q). Such plots typically result in a large cloud of data points where the slope of the lower bound of the cloud is often used to infer aquifer hydraulic properties as informed by certain interpretations of the Boussinesq Equation. For seven watersheds in New York State, USA ranging from 100 km2 to 6415 km2, we distinguish data points in the dQ/dt-Q plot belonging to individual recession events instead of looking at the entire data cloud. The recession curve of individual events consistently shifts upward during the summer and late fall (relative to spring and late fall curves) and much of the scatter in the data cloud appears to be due to seasonal variations in recession. We speculate that these seasonal variations in recession rate may be due to variations in watershed evapotranspiration (ET). Additionally, most individual recession events have slopes of approximately two when plotted as log dQ/dt versus log Q. Application of the Boussinesq Equation to watershed-scale recession date predicts slopes shifting from 3 to 3/2 as recession progresses, thus the observed slope of two casts doubt on whether it is appropriate to apply hydraulic aquifer theory to these types of watersheds to infer aquifer properties or predict low flows. As a further validation of the hydrologic information content of individual recession curves, the individual recession curves from time periods with minimal ET (early spring and late fall) were used to establish storage-discharge functions for two of the smaller watersheds. With these storage-discharge functions, a simple hydrologic model could reasonably simulate time series with minimal calibration (Nash-Sutcliffe R2 of 0.71 and 0.67 on log transformed discharge). Overall, this paper suggests that the analysis of individual event recession curves (particularly when compared among watersheds and seasons) can be a valuable tool for gaining insights into hydrological processes at the scale of large watersheds and can justify alternatives to current low flow models.

  13. Growth curve analysis of Rambouillet ewes

    E-print Network

    Mathenge, James Mwai

    1981-01-01

    for this study. However, most of the results were reported for 152 observations; a subset of the 283 records that contained the smst complete set of weighted' Type of birth and rearing was the single most significant source of variation for preweaning body... weights and growth rates. Estimation of mature weight obtained for 184 records was 59. 6 + . 77 kilograms. Based upon analysis of yearly weights, ewes had reached maturity by 42 months of age. Birth and 120-day weight were lower than those reported...

  14. Genetic Linkage Analysis of 15 DFNB Loci in a Group of Iranian Families with Autosomal Recessive Hearing Loss

    PubMed Central

    Tabatabaiefar, MA; Alasti, F; Zohour, M Montazer; Shariati, L; Farrokhi, E; Farhud, DD; Camp, GV; Noori-Daloii, MR; Chaleshtori, M Hashemzadeh

    2011-01-01

    Background: Hearing loss (HL) is the most frequent sensory birth defect in humans. Autosomal recessive non-syndromic HL (ARNSHL) is the most common type of hereditary HL. It is extremely heterogeneous and over 70 loci (known as DFNB) have been identified. This study was launched to determine the relative contribution of more frequent loci in a cohort of ARNSHL families. Methods: Thirty-seven Iranian families including 36 ARNSHL families and 1 family with Pendred syndrome each with ? 4 affected individuals, from seven provinces of Iran, were ascertained. DFNB1 contribution was initially studied by DNA sequencing of GJB2 and linkage analysis using the relative STR markers. The excluded families were then subjected to homozygosity mapping for fifteen ARNSHL loci. Results: Sixteen families were found to be linked to seven different known loci, including DFNB1 (6 families), DFNB4 (3 families +1 family with Pendred syndrome), DFNB63 (2 families), DFNB2 (1 family), DFNB7/11 (1 family), DFNB9 (1 family) and DFNB21 (1 family). DNA sequencing of the corresponding genes is in progress to identify the pathogenic mutations. Conclusion: The genetic causes were clarified in 43.2% of the studied families, giving an overview of the causes of ARNSHL in Iran. DFNB4 is ranked second after DFNB1 in the studied cohort. More genetic and epigenetic investigations will have to be done to reveal the causes in the remaining families. PMID:23113071

  15. Post buckling analysis of smart laminated doubly curved shells

    Microsoft Academic Search

    C. K. Kundu; D. K. Maiti; P. K. Sinha

    2007-01-01

    In the present investigation, the geometrically nonlinear post buckling analysis of piezoelectric laminated doubly curved shells is presented using finite element method. The piezoelectric material is used in the form of layers or patches embedded and\\/or surface bonded on laminated composite shells. The finite element model includes the general geometric nonlinearity due to large deflection. The shell geometry used in

  16. Resistance against Differential Power Analysis for Elliptic Curve Cryptosystems

    Microsoft Academic Search

    Jean-sébastien Coron; Ecole Normale; Superieure Gemplus

    1999-01-01

    . Differential Power Analysis, first introduced by Kocher etal. in [14], is a powerful technique allowing to recover secret smart cardinformation by monitoring power signals. In [14] a specific DPA attackagainst smart-cards running the DES algorithm was described. As few as1000 encryptions were sufficient to recover the secret key. In this paperwe generalize DPA attack to elliptic curve (EC) cryptosystems

  17. Statistical Analysis of Single-Molecule AFM Force Spectroscopy Curves

    E-print Network

    Schmidler, Scott

    Statistical Analysis of Single-Molecule AFM Force Spectroscopy Curves Alexei Valiaev1 , Stefan from single-molecule force spectroscopy (SMFS) measurements. We apply this methodology to force observed that arise from force-induced changes in the secondary and tertiary conformation of the molecule

  18. Genetic analysis and molecular mapping of a novel recessive gene xa34(t) for resistance against Xanthomonas oryzae pv. oryzae.

    PubMed

    Chen, Shen; Liu, Xinqiong; Zeng, Liexian; Ouyang, Dongmei; Yang, Jianyuan; Zhu, Xiaoyuan

    2011-05-01

    A new bacterial blight recessive resistance gene xa34(t) was identified from the descendant of somatic hybridization between an aus rice cultivar (cv.) BG1222 and susceptible cv. IR24 against Chinese race V (isolate 5226). The isolate was used to test the resistance or susceptibility of F(1) progenies and reciprocal crosses of the parents. The results showed that F(1) progenies appeared susceptibility there were 128R (resistant):378S (susceptible) and 119R:375S plants in F(2) populations derived from two crosses of BG1222/IR24 and IR24/BG1222, respectively, which both calculates into a 1R:3S ratio. 320 pairs of stochastically selected SSR primers were used for genes' initial mapping. The screened results showed that two SSR markers, RM493 and RM446, found on rice chromosome 1 linked to xa34(t). Linkage analysis showed that these two markers were on both sides of xa34(t) with the genetic distances 4.29 and 3.05 cM, respectively. The other 50 SSR markers in this region were used for genes' fine mapping. The further results indicated that xa34(t) was mapped to a 1.42 cM genetic region between RM10927 and RM10591. In order to further narrow down the genomic region of xa34(t), 43 of insertion/deletion (Indel) markers (BGID1-43) were designed according to the sequences comparison between japonica and indica rice. Parents' polymorphic detection and linkage assay showed that the Indel marker BGID25 came closer to the target gene with a 0.4 cM genetic distance. A contig map corresponding to the locus was constructed based on the reference sequences aligned by the xa34(t) linked markers. Consequently, the locus of xa34(t) was defined to a 204 kb interval flanked by markers RM10929 and BGID25. PMID:21274511

  19. Recess--It's Indispensable!

    ERIC Educational Resources Information Center

    Jarrett, Olga; Waite-Stupiansky, Sandra

    2009-01-01

    The demise of recess in many elementary schools--and of outdoor play in general--is an issue of great concern to many members of the Play, Policy, and Practice Interest Forum. Most people remember recess as an important part of the school day. It was a time to be outdoors; to organize games; to play on the swings, slides, and other playground…

  20. Recess Makes Kids Smarter

    ERIC Educational Resources Information Center

    Adams, Caralee

    2011-01-01

    Recess has been scaled back or cut altogether in a number of schools around the country. The trend can be traced back to the late eighties and was accelerated under No Child Left Behind. Districts under pressure to show academic progress began to squeeze as much instruction into the day as possible. Others eliminated recess because of concerns…

  1. Supplementary Analysis of Io's Disk-Integrated Solar Phase Curve

    Microsoft Academic Search

    Deborah L. Domingue; G. W. Lockwood; Amanda E. Kubala

    1998-01-01

    Analysis of the disk-integrated phase curves of Io's leading and trailing hemispheres, as derived from combined groundbased and Voyager spacecraft measurements, shows that Io's leading side is more porous than its trailing hemisphere (assuming a globally uniform particle grain size distribution) and that the material of the trailing side is more opaque at 0.47 and 0.55 ?m than the material

  2. Stress analysis in curved composites due to thermal loading

    NASA Astrophysics Data System (ADS)

    Polk, Jared Cornelius

    Many structures in aircraft, cars, trucks, ships, machines, tools, bridges, and buildings, consist of curved sections. These sections vary from straight line segments that have curvature at either one or both ends, segments with compound curvatures, segments with two mutually perpendicular curvatures or Gaussian curvatures, and segments with a simple curvature. With the advancements made in multi-purpose composites over the past 60 years, composites slowly but steadily have been appearing in these various vehicles, compound structures, and buildings. These composite sections provide added benefits over isotropic, polymeric, and ceramic materials by generally having a higher specific strength, higher specific stiffnesses, longer fatigue life, lower density, possibilities in reduction of life cycle and/or acquisition cost, and greater adaptability to intended function of structure via material composition and geometry. To be able to design and manufacture a safe composite laminate or structure, it is imperative that the stress distributions, their causes, and effects are thoroughly understood in order to successfully accomplish mission objectives and manufacture a safe and reliable composite. The objective of the thesis work is to expand upon the knowledge of simply curved composite structures by exploring and ascertaining all pertinent parameters, phenomenon, and trends in stress variations in curved laminates due to thermal loading. The simply curved composites consist of composites with one radius of curvature throughout the span of the specimen about only one axis. Analytical beam theory, classical lamination theory, and finite element analysis were used to ascertain stress variations in a flat, isotropic beam. An analytical method was developed to ascertain the stress variations in an isotropic, simply curved beam under thermal loading that is under both free-free and fixed-fixed constraint conditions. This is the first such solution to Author's best knowledge of such a problem. It was ascertained and proven that the general, non-modified (original) version of classical lamination theory cannot be used for an analytical solution for a simply curved beam or any other structure that would require rotations of laminates out their planes in space. Finite element analysis was used to ascertain stress variations in a simply curved beam. It was verified that these solutions reduce to the flat beam solutions as the radius of curvature of the beams tends to infinity. MATLAB was used to conduct the classical lamination theory numerical analysis. A MATLAB program was written to conduct the finite element analysis for the flat and curved beams, isotropic and composite. It does not require incompatibility techniques used in mechanics of isotropic materials for indeterminate structures that are equivalent to fixed-beam problems. Finally, it has the ability to enable the user to define and create unique elements not accessible in commercial software, and modify finite element procedures to take advantage of new paradigms.

  3. Dissection of the Hormetic Curve: Analysis of Components and Mechanisms

    PubMed Central

    Lushchak, Volodymyr I.

    2014-01-01

    The relationship between the dose of an effector and the biological response frequently is not described by a linear function and, moreover, in some cases the dose-response relationship may change from positive/adverse to adverse/positive with increasing dose. This complicated relationship is called “hormesis”. This paper provides a short analysis of the concept along with a description of used approaches to characterize hormetic relationships. The whole hormetic curve can be divided into three zones: I – a lag-zone where no changes are observed with increasing dose; II – a zone where beneficial/adverse effects are observed, and III – a zone where the effects are opposite to those seen in zone II. Some approaches are proposed to analyze the molecular components involved in the development of the hormetic character of dose-response relationships with the use of specific genetic lines or inhibitors of regulatory pathways. The discussion is then extended to suggest a new parameter (half-width of the hormetic curve at zone II) for quantitative characterization of the hormetic curve. The problems limiting progress in the development of the hormesis concept such as low reproducibility and predictability may be solved, at least partly, by deciphering the molecular mechanisms underlying the hormetic dose-effect relationship. PMID:25249836

  4. Stochastic analysis of the VEGF receptor response curve

    NASA Astrophysics Data System (ADS)

    MacNamara, Shev; Burrage, Kevin; Sidje, Roger B.

    2007-11-01

    Recently, an analysis of the response curve of the vascular endothelial growth factor (VEGF) receptor and its application to cancer therapy was described in [T. Alarcón, and K. Page, J. R. Soc. Lond. Interface 4, 283-304 (2007)]. The analysis is significantly extended here by demonstrating that an alternative computational strategy, namely the Krylov FSP algorithm for the direct solution of the chemical master equation, is feasible for the study of the receptor model. The new method allows us to further investigate the hypothesis of symmetry in the stochastic fluctuations of the response. Also, by augmenting the original model with a single reversible reaction we formulate a plausible mechanism capable of realizing a bimodal response, which is reported experimentally but which is not exhibited by the original model. The significance of these findings for mechanisms of tumour resistance to antiangiogenic therapy is discussed.

  5. Trends in population mental health before and after the 2008 recession: a repeat cross-sectional analysis of the 1991–2010 Health Surveys of England

    PubMed Central

    Katikireddi, Srinivasa Vittal; Niedzwiedz, Claire L; Popham, Frank

    2012-01-01

    Objective To assess short-term differences in population mental health before and after the 2008 recession and explore how and why these changes differ by gender, age and socio-economic position. Design Repeat cross-sectional analysis of survey data. Setting England. Participants Representative samples of the working age (25–64?years) general population participating in the Health Survey for England between 1991 and 2010 inclusive. Main outcome measures Prevalence of poor mental health (caseness) as measured by the general health questionnaire-12 (GHQ). Results Age–sex standardised prevalence of GHQ caseness increased from 13.7% (95% CI 12.9% to 14.5%) in 2008 to 16.4% (95% CI 14.9% to 17.9%) in 2009 and 15.5% (95% CI 14.4% to 16.7%) in 2010. Women had a consistently greater prevalence since 1991 until the current recession. However, compared to 2008, men experienced an increase in age-adjusted caseness of 5.1% (95% CI 2.6% to 7.6%, p<0.001) in 2009 and 3% (95% CI 1.2% to 4.9%, p=0.001) in 2010, while no statistically significant changes were seen in women. Adjustment for differences in employment status and education level did not account for the observed increase in men nor did they explain the differential gender patterning. Over the last decade, socio-economic inequalities showed a tendency to increase but no clear evidence for an increase in inequalities associated with the recession was found. Similarly, no evidence was found for a differential effect between age groups. Conclusions Population mental health in men has deteriorated within 2?years of the onset of the current recession. These changes, and their patterning by gender, could not be accounted for by differences in employment status. Further work is needed to monitor recessionary impacts on health inequalities in response to ongoing labour market and social policy changes. PMID:23075569

  6. Analysis of selected Kepler Mission planetary light curves

    E-print Network

    Rhodes, M D

    2014-01-01

    We have modified the graphical user interfaced close binary system analysis program CurveFit to the form WinKepler and applied it to 16 representative planetary candidate light curves found in the NASA Exoplanet Archive (NEA) at the Caltech website http://exoplanetarchive.ipac.caltech.edu, with an aim to compare different analytical approaches. WinKepler has parameter options for a realistic physical model, including gravity-brightening and structural parameters derived from the relevant Radau equation. We tested our best-fitting parameter-sets for formal determinacy and adequacy. A primary aim is to compare our parameters with those listed in the NEA. Although there are trends of agreement, small differences in the main parameter values are found in some cases, and there may be some relative bias towards a 90 degrees value for the NEA inclinations. These are assessed against realistic error estimates. Photometric variability from causes other than planetary transits affects at least 6 of the data-sets studie...

  7. An item response curves analysis of the Force Concept Inventory

    NASA Astrophysics Data System (ADS)

    Morris, Gary A.; Harshman, Nathan; Branum-Martin, Lee; Mazur, Eric; Mzoughi, Taha; Baker, Stephen D.

    2012-09-01

    Several years ago, we introduced the idea of item response curves (IRC), a simplistic form of item response theory (IRT), to the physics education research community as a way to examine item performance on diagnostic instruments such as the Force Concept Inventory (FCI). We noted that a full-blown analysis using IRT would be a next logical step, which several authors have since taken. In this paper, we show that our simple approach not only yields similar conclusions in the analysis of the performance of items on the FCI to the more sophisticated and complex IRT analyses but also permits additional insights by characterizing both the correct and incorrect answer choices. Our IRC approach can be applied to a variety of multiple-choice assessments but, as applied to a carefully designed instrument such as the FCI, allows us to probe student understanding as a function of ability level through an examination of each answer choice. We imagine that physics teachers could use IRC analysis to identify prominent misconceptions and tailor their instruction to combat those misconceptions, fulfilling the FCI authors' original intentions for its use. Furthermore, the IRC analysis can assist test designers to improve their assessments by identifying nonfunctioning distractors that can be replaced with distractors attractive to students at various ability levels.

  8. The Recess Renaissance

    ERIC Educational Resources Information Center

    Keeler, Rusty

    2015-01-01

    The author tells of his work around the country and world on transforming how schools do recess, free play, and outside time by transforming their outdoor spaces to match. Instead of a playground of fixed structures like traditional school grounds, newer spaces are filled with loose materials that children can use to build forts, dens, and tree…

  9. Descriptive and Predictive Growth Curves in Energy System Analysis

    Microsoft Academic Search

    Mikael Höök; Junchen Li; Noriaki Oba; Simon Snowden

    2011-01-01

    This study reviews a variety of growth curve models and the theoretical frameworks that lay behind them. In many systems,\\u000a growth patterns are, or must, ultimately be subjected to some form of limitation. A number of curve models have been developed\\u000a to describe and predict such behaviours. Symmetric growth curves have frequently been used for forecasting fossil fuel production,\\u000a but

  10. Bayesian classification and survival analysis with curve predictors

    E-print Network

    Wang, Xiaohui

    2009-05-15

    . . . . . . . . . . . . . . . . . . . . . . . . . . . . 54 15 Some examples of the functional covariates (serum bilirubin in mg/dl) curves over time in PBC data. The above plot contains curves from control group and the bottom one from drug group. . . . 69 16 The estimated trajectory of bilirubin levels... and the 90% credible bands. 70 17 Survival curves: Kaplan-Meier (dotted line), our estimated sur- vival curve based on bilirubin level (black solid line) and its 5th and 95th credible interval (black dash lines), and those estimations by Bayesian parametric...

  11. Growth curve analysis for plasma profiles using smoothing splines

    SciTech Connect

    Imre, K.

    1993-05-01

    We are developing a profile analysis code for the statistical estimation of the parametric dependencies of the temperature and density profiles in tokamaks. Our code uses advanced statistical techniques to determine the optimal fit, i.e. the fit which minimized the predictive error. For a forty TFTR Ohmic profile dataset, our preliminary results indicate that the profile shape depends almost exclusively on q[sub a][prime] but that the shape dependencies are not Gaussian. We are now comparing various shape models on the TFTR data. In the first six months, we have completed the core modules of the code, including a B-spline package for variable knot locations, a data-based method to determine the optimal smoothing parameters, self-consistent estimation of the bias errors, and adaptive fitting near the plasma edge. Visualization graphics already include three dimensional surface plots, and discharge by discharge plots of the predicted curves with error bars together with the actual measurements values, and plots of the basis functions with errors.

  12. Inverse Analysis of Multiple Indentation Unloading Curves for Thin Film Young's Modulus Evaluation

    E-print Network

    Paris-Sud XI, Université de

    Inverse Analysis of Multiple Indentation Unloading Curves for Thin Film Young's Modulus Evaluation the assumptions of an elastic unloading and small strains, Oliver and Pharr used Sneddon's closed form solution experiments. The idea is also based on the unloading curve combined with an inverse analysis of the data

  13. Comparison of Emperical Decline Curve Analysis for Shale Wells 

    E-print Network

    Kanfar, Mohammed Sami

    2013-07-13

    This study compares four recently developed decline curve methods and the traditional Arps or Fetkovich approach. The four methods which are empirically formulated for shale and tight gas wells are: 1. Power Law Exponential Decline (PLE). 2...

  14. FDTD analysis of dielectric resonators with curved surfaces

    Microsoft Academic Search

    Noriaki Kaneda; Bijan Houshmand; Tatsuo Itoh

    1997-01-01

    In this paper, the finite-difference time-domain (FDTD) method is applied to calculate the resonant frequency of dielectric resonators (DRs) with curved surface. The contour-path integral FDTD (CFDTD) is modified to deal with the curved surface of the dielectric body while the traditional rectangular cells are maintained. Results are compared with theoretical values and staircase approximation, and show that the present

  15. Automatic generation and analysis of solar cell IV curves

    SciTech Connect

    Kraft, Steven M.; Jones, Jason C.

    2014-06-03

    A photovoltaic system includes multiple strings of solar panels and a device presenting a DC load to the strings of solar panels. Output currents of the strings of solar panels may be sensed and provided to a computer that generates current-voltage (IV) curves of the strings of solar panels. Output voltages of the string of solar panels may be sensed at the string or at the device presenting the DC load. The DC load may be varied. Output currents of the strings of solar panels responsive to the variation of the DC load are sensed to generate IV curves of the strings of solar panels. IV curves may be compared and analyzed to evaluate performance of and detect problems with a string of solar panels.

  16. Spectral curve fitting for automatic hyperspectral data analysis

    Microsoft Academic Search

    Adrian Jon Brown

    2006-01-01

    Automatic discovery and curve fitting of absorption bands in hyperspectral data can enable the analyst to identify materials present in a scene by comparison with library spectra. This procedure is common in laboratory spectra, but is challenging for sparse hyperspectral data. A procedure for robust discovery of overlapping bands in hyperspectral data is described in this paper. The method is

  17. Selecting Elliptic Curves for Cryptography: An Efficiency and Security Analysis

    E-print Network

    Costello, Patrick Longa and Michael Naehrig Microsoft Research, USA Abstract. We select a set of elliptic shapes which allow faster modular arithmetic, #12;2 Joppe W. Bos, Craig Costello, Patrick Longa and Michael Naehrig and a larger set of curve models from which to choose. For example, in 2007, Edwards [22

  18. Bayesian Analysis of Longitudinal Data Using Growth Curve Models

    ERIC Educational Resources Information Center

    Zhang, Zhiyong; Hamagami, Fumiaki; Wang, Lijuan Lijuan; Nesselroade, John R.; Grimm, Kevin J.

    2007-01-01

    Bayesian methods for analyzing longitudinal data in social and behavioral research are recommended for their ability to incorporate prior information in estimating simple and complex models. We first summarize the basics of Bayesian methods before presenting an empirical example in which we fit a latent basis growth curve model to achievement data…

  19. Method of lines for the analysis of the propagation characteristics of curved optical rib waveguides

    Microsoft Academic Search

    Jing-Song Gu; P.-A. Besse; H. Melchior

    1991-01-01

    A numerical technique based on the method of lines is developed for the analysis of curved optical rib waveguides. The approach yields accurate solutions for the modes of both polarizations propagating along the curved waveguides. The values of the calculated bending losses are substantiated by experimental results. The method of lines has proven to be very efficient for the solution

  20. Inflation Dynamics and the Great Recession Laurence Ball and Sandeep Mazumder

    E-print Network

    Niebur, Ernst

    Inflation Dynamics and the Great Recession Laurence Ball and Sandeep Mazumder May 2011 Abstract This paper examines inflation dynamics in the Unites States since 1960, with a particular focus on the Great Recession. A puzzle emerges when Phillips curves estimated over 1960- 2007 are used to predict inflation

  1. The Study of SLC26A4 Gene Causing Autosomal Recessive Hearing Loss by Linkage Analysis in a Cohort of Iranian Populations

    PubMed Central

    Reiisi, Somayeh; Sanati, Mohammad Hosein; Tabatabaiefar, Mohammad Amin; Ahmadian, Shahla; Reiisi, Salimeh; Parchami, Shahrbanoo; Porjafari, Hamid; Shahi, Heshmat; Shavarzi, Afsaneh; Hashemzade Chaleshtori, Morteza

    2014-01-01

    Sensorineural non-syndromic hearing loss is the most common disorder which affects 1 in 500 newborns. Hearing loss is an extremely heterogeneous defect with more than 100 loci identified to date. According to the studies, mutations in GJB2 are estimated to be involved in 50- 80% of autosomal recessive non-syndromic hearing loss cases, but contribution of other loci in this disorder is yet ambiguous. With regard to studies, DFNB4 locus (SLC26A4) can be classified as the second cause of hearing loss. So, this study aimed to determine the contribution of this locus in hearing loss as well as the frequency of SLC26A4 gene mutations in a population in the west of Iran. In this descriptive laboratory study, we included 30 families from the west of Iran with no mutation in GJB2 gene. Linkage analysis was performed by DFNB4 (SLC26A4) molecular markers (STR). The families with hearing loss linked to this locus were further analyzed for mutation detection. SLC26A4 gene exons were amplified and analyzed using direct DNA sequencing. In studied families, 2 families displayed linkage to DFNB4 locus. Identified mutations include mutation in exon 5 (c.416 G>T) and in splicing site of exon 7 (IVS-2 A>G or c.919-2 A>G). PMID:25317404

  2. A penalty model for the analysis of curved composite beams

    NASA Astrophysics Data System (ADS)

    Ascione, L.; Fraternali, F.

    1992-12-01

    A simple one-dimensional mechanical model for curved laminated beams is presented. The laminate composing the beam are modeled as Timoshenko beams, perfectly bonded at the interfaces. Because the laminate can rotate differently from one to the other, the cross-sections of the composite beam can warp. The elasto-static problem of the beam is formulated through the principle of stationary potential energy, imposing constraint conditions between the displacements of adjacent laminate by a penalty technique. This approach produces an approximation of radial and tangential interactions between adjacent laminae. By using four-node isoparametric finite elements, numerical values of interlaminar stresses in straight and curved laminated beams are given. They are compared with the results obtained by other authors under different conditions.

  3. Automatic Segmentation of Scanned Human Body Using Curve Skeleton Analysis

    Microsoft Academic Search

    Christian Lovato; Umberto Castellani; Andrea Giachetti

    2009-01-01

    In this paper we present a method for the automatic processing of scanned human body data consisting of an algorithm for the\\u000a extraction of curve skeletons of the 3D models acquired and a procedure for the automatic segmentation of skeleton branches.\\u000a Models used in our experiments are obtained with a whole-body scanner based on structured light (Breuckmann bodySCAN, owned\\u000a by

  4. The icy Galilean satellites: ultraviolet phase curve analysis

    NASA Astrophysics Data System (ADS)

    Hendrix, Amanda R.; Domingue, Deborah L.; King, Kimberly

    2005-01-01

    Ultraviolet disk-integrated solar phase curves of the icy galilean satellites Europa, Ganymede, and Callisto are presented, using combined data sets from the International Ultraviolet Explorer (IUE), Hubble Space Telescope (HST), and the Galileo Ultraviolet Spectrometer. Global, disk-integrated solar phase curves for all three satellites, in addition to disk-integrated solar phase curves for Europa's leading, trailing, jovian, and anti-jovian hemispheres, are modeled using Hapke's equations for 7 broadband UV wavelengths between 260 and 320 nm. The sparse coverage in solar phase angle, particularly for Ganymede and Callisto, and the noise in the data sets poorly constrain some of the photometric parameter values in the model. However, the results are sufficient for forming a preliminary relationship between the effects of particle bombardment on icy surfaces and photometric scattering properties at ultraviolet wavelengths. Callisto exhibits a large UV opposition surge and a surface comprised of relatively low-backward scattering particles. Europa's surface displays a dichotomy between the jovian and anti-jovian hemispheres (the anti-jovian hemisphere is more backward scattering), while a less pronounced hemispherical variation was detected between the leading and trailing hemispheres. Europa's surface, with the exception of the trailing hemisphere region, appears to have become less backscattering between the late-1970s-early-1980s and the mid-1990s. These results are commensurate with the bombardment history of these surfaces by magnetospheric charged particles.

  5. Autosomal recessive congenital ichthyosis.

    PubMed

    Rodríguez-Pazos, L; Ginarte, M; Vega, A; Toribio, J

    2013-05-01

    The term autosomal recessive congenital ichthyosis (ARCI) refers to a group of rare disorders of keratinization classified as nonsyndromic forms of ichthyosis. This group was traditionally divided into lamellar ichthyosis (LI) and congenital ichthyosiform erythroderma (CIE) but today it also includes harlequin ichthyosis, self-healing collodion baby, acral self-healing collodion baby, and bathing suit ichthyosis. The combined prevalence of LI and CIE has been estimated at 1 case per 138 000 to 300 000 population. In some countries or regions, such as Norway and the coast of Galicia, the prevalence may be higher due to founder effects. ARCI is genetically highly heterogeneous and has been associated with 6 genes to date: TGM1, ALOXE3, ALOX12B, NIPAL4, CYP4F22, and ABCA12. In this article, we review the current knowledge on ARCI, with a focus on clinical, histological, ultrastructural, genetic, molecular, and treatment-related aspects. PMID:23562412

  6. A new explanation for recessive myotonia congenita

    PubMed Central

    Raja Rayan, D.L.; Haworth, A.; Sud, R.; Matthews, E.; Fialho, D.; Burge, J.; Portaro, S.; Schorge, S.; Tuin, K.; Lunt, P.; McEntagart, M.; Toscano, A.; Davis, M.B.

    2012-01-01

    Objective: To assess whether exon deletions or duplications in CLCN1 are associated with recessive myotonia congenita (MC). Methods: We performed detailed clinical and electrophysiologic characterization in 60 patients with phenotypes consistent with MC. DNA sequencing of CLCN1 followed by multiplex ligation-dependent probe amplification to screen for exon copy number variation was undertaken in all patients. Results: Exon deletions or duplications in CLCN1 were identified in 6% of patients with MC. Half had heterozygous exonic rearrangements. The other 2 patients (50%), with severe disabling infantile onset myotonia, were identified with both a homozygous mutation, Pro744Thr, which functional electrophysiology studies suggested was nonpathogenic, and a triplication/homozygous duplication involving exons 8–14, suggesting an explanation for the severe phenotype. Conclusions: These data indicate that copy number variation in CLCN1 may be an important cause of recessive MC. Our observations suggest that it is important to check for exon deletions and duplications as part of the genetic analysis of patients with recessive MC, especially in patients in whom sequencing identifies no mutations or only a single recessive mutation. These results also indicate that additional, as yet unidentified, genetic mechanisms account for cases not currently explained by either CLCN1 point mutations or exonic deletions or duplications. PMID:22649220

  7. Determination of the optimum working range from a calibration curve for colorimetric analysis with an "autoanalyzer".

    PubMed

    Whitehead, D

    1973-02-01

    A study has been made of the types and distribution of errors in determining the optimum working range from a calibration curve for automated analysis. Three error equations are derived for the fitting of a linear, quadratic or cubic curve, involving a thorough statistical analysis of the data. The errors from a set of silica and alumina standards, requiring a quadratic and cubic fit respectively, compare favourably with replicate analyses of standard rocks done on a previous occasion. PMID:18961254

  8. Estimation of isodose curves in radiation therapy and related response analysis

    E-print Network

    Goodlett, James Campbell

    1967-01-01

    ESTIMATION OF ISODOSE CURVES IN RADIATION THERAPY AND RELATED RESPONSE ANALYSIS A Thesis By JAMES CAMPBELL GOODLETT Submitted to the Graduate College oi' the Texas A@M University in partial fulfillment of the requirements for the degree... of MASTER OF SCIENCE May 1967 Major Subject: Statistic s ESTIMATION OF ISODOSE CURVES IN RADIATION THERAPY AND RELATED RESPONSE ANALYSIS A Thesis By JAMES CAMPBELL GOODLETT Approved as and content by: ( airm n of Committee) Ot~+ (Head...

  9. Effects of recess dimensions on performance of the recessed cathode dissolved oxygen sensor

    Microsoft Academic Search

    Tae-Sun Lim; Jin-Hwan Lee; Ian Papautsky

    2008-01-01

    This paper describes the effects of recess dimensions on performance of recessed cathode dissolved oxygen (DO) microelectrode sensors. Microelectrodes with different recess dimensions were fabricated and characterized to establish the relationship between recess dimensions and sensor performance. The square-ring type cathode geometry inside the recess was formed with the recess length ranging from 35 to 246 mum and the length

  10. Transit Light Curves with Finite Integration Time: Fisher Information Analysis

    NASA Astrophysics Data System (ADS)

    Price, Ellen M.; Rogers, Leslie A.

    2014-10-01

    Kepler has revolutionized the study of transiting planets with its unprecedented photometric precision on more than 150,000 target stars. Most of the transiting planet candidates detected by Kepler have been observed as long-cadence targets with 30 minute integration times, and the upcoming Transiting Exoplanet Survey Satellite will record full frame images with a similar integration time. Integrations of 30 minutes affect the transit shape, particularly for small planets and in cases of low signal to noise. Using the Fisher information matrix technique, we derive analytic approximations for the variances and covariances on the transit parameters obtained from fitting light curve photometry collected with a finite integration time. We find that binning the light curve can significantly increase the uncertainties and covariances on the inferred parameters when comparing scenarios with constant total signal to noise (constant total integration time in the absence of read noise). Uncertainties on the transit ingress/egress time increase by a factor of 34 for Earth-size planets and 3.4 for Jupiter-size planets around Sun-like stars for integration times of 30 minutes compared to instantaneously sampled light curves. Similarly, uncertainties on the mid-transit time for Earth and Jupiter-size planets increase by factors of 3.9 and 1.4. Uncertainties on the transit depth are largely unaffected by finite integration times. While correlations among the transit depth, ingress duration, and transit duration all increase in magnitude with longer integration times, the mid-transit time remains uncorrelated with the other parameters. We provide code in Python and Mathematica for predicting the variances and covariances at www.its.caltech.edu/~eprice.

  11. Type-curve analysis of pressure buildup from vertically fractured wells in low permeability reservoirs

    SciTech Connect

    Not Available

    1982-03-01

    Intercomp has developed a set of type curves for use in analyzing pressure buildup data from vertically fractured wells. The new curves account for the length of time the well was on production before it was shut-in for the buildup test. Estimates of permeability, fracture half-length, and fracture conductivity are given from pressure buildup analysis using the curves. We found that the results from Horner analysis of pressure buildup data from vertically fractured wells are affected by the length of time a well was on production prior to starting the buildup test. Long dimensionless flow times are needed for the Horner straight line to develop. This means that extremely long flow times are needed for Horner analysis to be used on pressure buildup data from massive hydraulic fractured wells in low permeability reservoirs. Several examples are given of analyzing pressure buildup data using the new type curves.

  12. Production data analysis type curves for the Devonian Shales 

    E-print Network

    Hazlett, William Gregory

    1985-01-01

    . : "Well Test Analysis for Devonian Shale Wells, " University of Tulsa Report, DOE Contract No. DE-AC21- 80MC14645, September 1981. 8. Kazemi, H. : "Pressure Transient Analysis of Naturally Fractured Reservoirs with UniPorm Fracture Distribution, " Soc...

  13. Fast and accurate analysis of 3-D curved optical waveguide couplers

    Microsoft Academic Search

    D. Z. Djurdjevic; T. M. Benson; P. Sewell; A. Vukovic

    2004-01-01

    The structure-related (SR) finite-difference beam-propagation method is applied to integrated optical couplers employing curved waveguide sections. A general nonorthogonal coordinate system is introduced that matches the local structure geometry, yielding a more accurate analysis with coarser meshes than standard schemes, thus providing significant computational resource savings. Furthermore, the algorithm is easily interfaced with conventional schemes. Examples of curved two-dimensional and

  14. Characterization of the mutation causative for autosomal recessive hereditary nephropathy in the english cocker spaniel and analysis of gene expression in multiple models of hereditary nephropathy 

    E-print Network

    Davidson, Ashley Greene

    2009-05-15

    syndrome (AS), a group of heterogeneous, hereditary renal diseases, is one example of such a human disease. The disease is transmitted in three fashions: X-linked, autosomal recessive, and autosomal dominant. AS is caused by mutations in COL4?3, COL4?4...

  15. Molecular Analysis of 250 Patients with Autosomal Recessive Congenital Ichthyosis: Evidence for Mutation Hotspots in ALOXE3 and Allelic Heterogeneity in ALOX12B

    Microsoft Academic Search

    Katja-Martina Eckl; Silvia de Juanes; Janine Kurtenbach; Marc Nätebus; Jenny Lugassy; Vinzenz Oji; Heiko Traupe; Marie-Luise Preil; Francisco Martínez; Josef Smolle; Avikam Harel; Peter Krieg; Eli Sprecher; Hans C Hennies

    2009-01-01

    In recent years several new genes for autosomal recessive congenital ichthyosis (ARCI) have been identified. However, little is known about the molecular epidemiology and pathophysiology of this genetically and clinically heterogeneous group of severe disorders of keratinization. ARCI is characterized by intense scaling of the whole integument often associated with erythema. We and others have shown that mutations in ALOX12B

  16. Characterization of the mutation causative for autosomal recessive hereditary nephropathy in the english cocker spaniel and analysis of gene expression in multiple models of hereditary nephropathy

    E-print Network

    Davidson, Ashley Greene

    2009-05-15

    syndrome (AS), a group of heterogeneous, hereditary renal diseases, is one example of such a human disease. The disease is transmitted in three fashions: X-linked, autosomal recessive, and autosomal dominant. AS is caused by mutations in COL4?3, COL4?4...

  17. The analysis of magnetization curves with skewed generalized Gaussian functions (SGG)

    Microsoft Academic Search

    E. Egli

    2003-01-01

    Induced and remanent (de)magnetization curves can be fitted using model functions, which are generally derived from logarithmic Gaussian distributions (LG). Each model function is interpreted as a magnetic component, and the procedure is called component analysis (Robertson and France, 1994). The success of component analysis is limited by two main factors: the ability of the model function to reproduce appropriately

  18. Application of the normalization data analysis technique for single specimen R-curve determination

    SciTech Connect

    Porr, W.C.; Mills, W.J.

    1999-03-01

    The authors conclude that the normalization technique for single specimen R-curve and J{sub IC} determination can be very effective. Much like EPD, this technique requires some user interpretation/judgement during data analysis and may be difficult to standardize or fully automate even with strict analysis rules.

  19. School Recess: Implications for Education and Development.

    ERIC Educational Resources Information Center

    Pellegrini, A. D.; Smith, Peter K.

    1993-01-01

    Empirical research on the role of school recess is reviewed. Effects of child-level and school-level variables on recess behavior and the impact of recess on classroom behavior and social and cognitive competence are discussed. It is concluded that recess has important educational and developmental implications. (SLD)

  20. The analysis of magnetization curves with skewed generalized Gaussian functions (SGG)

    NASA Astrophysics Data System (ADS)

    Egli, E.

    2003-04-01

    Induced and remanent (de)magnetization curves can be fitted using model functions, which are generally derived from logarithmic Gaussian distributions (LG). Each model function is interpreted as a magnetic component, and the procedure is called component analysis (Robertson and France, 1994). The success of component analysis is limited by two main factors: the ability of the model function to reproduce appropriately the magnetic properties of an individual component, and its extreme sensitivity to measurement errors. Both factors influence the number of components which are needed to fit a magnetization curve within the measurement error. The effect of measurement errors on the significance of a component analysis can be tested statistically (e.g. Kruiver et al., 2002). On the other hand, theoretical and experimental magnetization curves of single domain and multidomain particles cannot be modelled using a single LG function (Egli, 2003). Therefore, more general functions, called skewed generalized Gaussian functions (SGG), were introduced in order to model appropriately the four main parameters of a (de)magnetization curve: median acquisition/destructive field, dispersion parameter, skewness and kurtosis. Two computer programs were developed to analyze a (de)magnetization curve. The first calculates a coercivity distribution as the first derivative of the magnetization curve and removes the measurement errors. It also performs an error estimation and gives confidence limits for the resulting coercivity distribution. The second program performs a component analysis with SGG functions. Advantages and limitations of this new method are discussed using some examples of component analysis performed on a variety of sediment samples. Egli, R., Analysis of the field dependence of remanent magnetization curves, Journal of Geophysical Research, in press. Kruiver, P. P., M. J. Dekkers and D. Heslop, Quantification of magnetic coercivity components by the analysis of acquisition curves of isothermal remanent magnetization, Earth Planet. Sci. Lett., 189, 269-276, 2001. Robertson, D. J. and D. E. France, Discrimination of remanence-carrying minerals in mixtures, using isothermal remanent magnetisation acquisition curves, Phys. Earth Planet. Inter., 82, 223-234, 1994.

  1. Light curve morphology analysis of contact binaries observed with the Kepler satellite

    NASA Astrophysics Data System (ADS)

    Debski, Bart?omiej; Zo?a, Stanis?aw

    2014-09-01

    Light-curve morphology analysis of contact binaries provides model-independent insight into the short-term evolution of the system activity. Light-curve morphology applied to the Kepler data of contact binaries reveals directly the migration spot connection to the light curve's intrinsic rapid changes. Since the flat-bottom secondary minima cannot be studied in the way Tran et al. (2013) or Conroy et al. (2014) did, we measure the actual light-curve minimum, instead of the presumed mid-eclipse time. This, combined with the study of the minimum depth, allowed us to uncover the direction of the spot migration for particular binaries. At the same time, the O'Connell effect evolution and the maxima separation confronted with modeling based on the Wilson-Devinney code agree with polar dark spots. The combined results of this new approach offer constraints on the star spots size, temperature and latitude at high precision.

  2. AtomicJ: an open source software for analysis of force curves.

    PubMed

    Hermanowicz, Pawe?; Sarna, Micha?; Burda, Kvetoslava; Gabry?, Halina

    2014-06-01

    We present an open source Java application for analysis of force curves and images recorded with the Atomic Force Microscope. AtomicJ supports a wide range of contact mechanics models and implements procedures that reduce the influence of deviations from the contact model. It generates maps of mechanical properties, including maps of Young's modulus, adhesion force, and sample height. It can also calculate stacks, which reveal how sample's response to deformation changes with indentation depth. AtomicJ analyzes force curves concurrently on multiple threads, which allows for high speed of analysis. It runs on all popular operating systems, including Windows, Linux, and Macintosh. PMID:24985823

  3. AtomicJ: An open source software for analysis of force curves

    SciTech Connect

    Hermanowicz, Pawe?, E-mail: pawel.hermanowicz@uj.edu.pl; Gabry?, Halina [Department of Plant Biotechnology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Gronostajowa 7, 30–387 Kraków (Poland); Sarna, Micha?; Burda, Kvetoslava [Department of Medical Physics and Biophysics, Faculty of Physics and Applied Computer Science, AGH University of Science and Technology, al. Mickiewicza 30, 30-059 Kraków (Poland)

    2014-06-15

    We present an open source Java application for analysis of force curves and images recorded with the Atomic Force Microscope. AtomicJ supports a wide range of contact mechanics models and implements procedures that reduce the influence of deviations from the contact model. It generates maps of mechanical properties, including maps of Young's modulus, adhesion force, and sample height. It can also calculate stacks, which reveal how sample's response to deformation changes with indentation depth. AtomicJ analyzes force curves concurrently on multiple threads, which allows for high speed of analysis. It runs on all popular operating systems, including Windows, Linux, and Macintosh.

  4. IEEE TRANSACTIONS ON PATTERN ANALYSIS AND MACHINE INTELLIGENCE, VOL. ?, NO. ?, 2011 1 Curved Glide-Reflection Symmetry Detection

    E-print Network

    IEEE TRANSACTIONS ON PATTERN ANALYSIS AND MACHINE INTELLIGENCE, VOL. ?, NO. ?, 2011 1 Curved Glide-Reflection feature-based ap- proach for curved glide-reflection symmetry detection from real, unsegmented 2D images the concept of bilateral reflection symmetry to curved glide-reflection symmetry in 2-dimensional Euclidean

  5. Textural Analysis of Dipmeter Curves Using Multifractal Statistics

    NASA Astrophysics Data System (ADS)

    Muller, J.; Saucier, A.; Huseby, O. K.; Khue, P. N.

    High resolution microresistivity well logs contain valuable information not only on the dip angle of the stratigraphic layers, but also on the texture (variability) of the geological formations in petroleum reservoirs. In order to extract the textural information from well logs, it would be useful to have a way of compressing the detailed information of microresistivities i.e. to extract from consecutive segments of the signal a series of parameters describing its local variability. The major objective of this paper is to achieve a quantitative representation of multipoint correlations in the dipmeter microresistivity signal. For this purpose, we show how general multifractal analysis /1/ can be used to extract a compact representation of multipoint statistics for the purpose of characterisation of geological layers. Reference: /1/ A. Saucier and J. Muller A Generalization of Multifractal Analysis Based on Polynomial Expansions of the Generating Function Fractals: Theory and Applications in Engineering, ed. M. Dekking, J. Levy Vehel, E. Lutton and C. Tricot, Springer (1999) p. 81

  6. Testing and analysis of flat and curved panels with multiple cracks

    NASA Technical Reports Server (NTRS)

    Broek, David; Jeong, David Y.; Thomson, Douglas

    1994-01-01

    An experimental and analytical investigation of multiple cracking in various types of test specimens is described in this paper. The testing phase is comprised of a flat unstiffened panel series and curved stiffened and unstiffened panel series. The test specimens contained various configurations for initial damage. Static loading was applied to these specimens until ultimate failure, while loads and crack propagation were recorded. This data provides the basis for developing and validating methodologies for predicting linkup of multiple cracks, progression to failure, and overall residual strength. The results from twelve flat coupon and ten full scale curved panel tests are presented. In addition, an engineering analysis procedure was developed to predict multiple crack linkup. Reasonable agreement was found between predictions and actual test results for linkup and residual strength for both flat and curved panels. The results indicate that an engineering analysis approach has the potential to quantitatively assess the effect of multiple cracks in the arrest capability of an aircraft fuselage structure.

  7. On the use of Principal Component Analysis in analysing Cepheid light curves

    NASA Astrophysics Data System (ADS)

    Kanbur, S. M.; Iono, D.; Tanvir, N. R.; Hendry, M. A.

    2002-01-01

    We show how Principal Component Analysis can be used to analyse the structure of Cepheid light curves. This method is more efficient than Fourier analysis at bringing out changes in light curve shape as a function of period. Using this technique, we study the shape of fundamental and first-overtone mode Cepheid light curves in the Galaxy, LMC and SMC over a wide period range. For fundamentals, we find evidence for structural changes at logP~1.55,2.1. It is suggested that the feature at logP~2.1 is associated with a resonance in the Cepheid normal-mode spectrum. For overtones, we recover the Z shape in the R21 period plane and reproduce the metallicity dependence of this Z shape.

  8. TTF HOM Data Analysis with Curve Fitting Method

    SciTech Connect

    Pei, S.; Adolphsen, C.; Li, Z.; Bane, K.; Smith, J.; /SLAC

    2009-07-14

    To investigate the possibility of using HOM signals induced in SC cavities as beam and cavity diagnostics, narrow band (20 MHz) data was recorded around the strong TE111-6(6{pi}/9-like) dipole modes (1.7 GHz) in the 40 L-band (1.3 GHz) cavities at the DESY TTF facility. The analyses of these data have so far focused on using a Singular Value Decomposition (SVD) technique to correlate the signals with each other and data from conventional BPMs to show the dipole signals provide an alternate means of measuring the beam trajectory. However, these analyses do not extract the modal information (i.e., frequencies and Q's of the nearly degenerate horizontal and vertical modes). In this paper, we described a method to fit the signal frequency spectrum to obtain this information, and then use the resulting mode amplitudes and phases together with conventional BPM data to determine the mode polarizations and relative centers and tilts. Compared with the SVD analysis, this method is more physical, and can also be used to obtain the beam position and trajectory angle.

  9. Soil hydraulic properties estimate based on numerical analysis of disc infiltrometer three-dimensional infiltration curve

    NASA Astrophysics Data System (ADS)

    Latorre, Borja; Peña-Sancho, Carolina; Angulo-Jaramillo, Rafaël; Moret-Fernández, David

    2015-04-01

    Measurement of soil hydraulic properties is of paramount importance in fields such as agronomy, hydrology or soil science. Fundamented on the analysis of the Haverkamp et al. (1994) model, the aim of this paper is to explain a technique to estimate the soil hydraulic properties (sorptivity, S, and hydraulic conductivity, K) from the full-time cumulative infiltration curves. The method (NSH) was validated by means of 12 synthetic infiltration curves generated with HYDRUS-3D from known soil hydraulic properties. The K values used to simulate the synthetic curves were compared to those estimated with the proposed method. A procedure to identify and remove the effect of the contact sand layer on the cumulative infiltration curve was also developed. A sensitivity analysis was performed using the water level measurement as uncertainty source. Finally, the procedure was evaluated using different infiltration times and data noise. Since a good correlation between the K used in HYDRUS-3D to model the infiltration curves and those estimated by the NSH method was obtained, (R2 =0.98), it can be concluded that this technique is robust enough to estimate the soil hydraulic conductivity from complete infiltration curves. The numerical procedure to detect and remove the influence of the contact sand layer on the K and S estimates seemed to be robust and efficient. An effect of the curve infiltration noise on the K estimate was observed, which uncertainty increased with increasing noise. Finally, the results showed that infiltration time was an important factor to estimate K. Lower values of K or smaller uncertainty needed longer infiltration times.

  10. A functional analysis of electrical load curve modelling for some households specific electricity end-uses

    E-print Network

    Paris-Sud XI, Université de

    A functional analysis of electrical load curve modelling for some households specific electricity a series of deep technical and behavioural breaks. Among them are : the integration of new electrical domestic end-uses, the development of plug-in hybrid and electric vehicles, the increase of heat pumps

  11. Analysis of horizontally curved post-tensioned segmental concrete box girder bridges

    Microsoft Academic Search

    Rafael Manuel Rojas

    1993-01-01

    This report presents the background and details of a numerical procedure developed specifically for the longitudinal analysis of curved segmentally erected prestressed concrete box girder bridges. It is based on a skew ended thin-wall beam element including the modes of warping and distorsion of the cross section. The cross section must consist of a single cell, may have overhangs, and

  12. Nonlinear Analysis of the Light Curve of the Variable Star R Scuti

    Microsoft Academic Search

    J. R. Buchler; Z. Kollath; T. Serre; J. Mattei

    1996-01-01

    It is first shown that the observational light curve data of R Scuti, a star of the RV Tau type, is not multiperiodic and that it cannot have been generated by a linear stochastic (AR) process. By default, the signal must be a manifestation of deterministic chaos. We use a novel nonlinear time series analysis, the global flow reconstruction technique,

  13. In-plane vibration analysis of curved carbon nanotubes conveying fluid embedded in viscoelastic medium

    Microsoft Academic Search

    Esmaeal Ghavanloo; Masoud Rafiei; Farhang Daneshmand

    2011-01-01

    The effect of the induced vibrations in the carbon nanotubes (CNTs) arising from the internal fluid flow is a critical issue in the design of CNT-based fluidic devices. In this study, in-plane vibration analysis of curved CNTs conveying fluid embedded in viscoelastic medium is investigated. The CNT is modeled as a linear elastic cylindrical tube where the internal moving fluid

  14. Linearized limb-darkening coefficients for use in analysis of eclipsing binary light curves

    Microsoft Academic Search

    Hamid M. Al-Naimiy

    1978-01-01

    Linear limb-darkening coefficientsu required in the analysis of eclipsing binary curves, are tabulated for a wide range of effective temperature (50 000° to 4000°), wavelength ? (0.2 µ=?=2.2 µ), and gravitiesg (2.0=logg=5.0). The computation is based on the comprehensive range of model atmospheres of Carbon and Gingerich (1969).

  15. Genuine power curves in forgetting: A quantitative analysis of individual subject

    E-print Network

    Wixted, John T.

    Genuine power curves in forgetting: A quantitative analysis of individual subject forgetting described by the power function, at b, where a and b are free parameters. However, all of their analyses that the power law of forgetting may be an artifact of arithmetically averaging individual subject forgetting

  16. Aptitude-Treatment Interaction Effects on Explicit Rule Learning: A Latent Growth Curve Analysis

    ERIC Educational Resources Information Center

    Hwu, Fenfang; Pan, Wei; Sun, Shuyan

    2014-01-01

    Finding the match between individuals and educational treatments is the aim of both educators and the aptitude-treatment interaction research paradigm. Using the latent growth curve analysis, the present study investigates the interaction between the type of explicit instructional approaches (deductive vs. explicit-inductive) and the level of…

  17. Policy Effectiveness and the Slopes of IS and LM Curves: A Graphical Analysis.

    ERIC Educational Resources Information Center

    Revier, Charles F.

    2000-01-01

    Focuses on the IS-LM model providing a graphical analysis designed to clarify the confusion induced by misleading statements in several major macroeconomics textbooks concerning the connection between policy effectiveness and the slopes of the IS and LM curves. Includes references. (CMK)

  18. Taxometrics, Polytomous Constructs, and the Comparison Curve Fit Index: A Monte Carlo Analysis

    ERIC Educational Resources Information Center

    Walters, Glenn D.; McGrath, Robert E.; Knight, Raymond A.

    2010-01-01

    The taxometric method effectively distinguishes between dimensional (1-class) and taxonic (2-class) latent structure, but there is virtually no information on how it responds to polytomous (3-class) latent structure. A Monte Carlo analysis showed that the mean comparison curve fit index (CCFI; Ruscio, Haslam, & Ruscio, 2006) obtained with 3…

  19. Development of synthetic flood damage curve by explicit costs analysis

    NASA Astrophysics Data System (ADS)

    Martina, Mario; Molinari, Daniela; Dottori, Francesco; Scorzini, Annarita

    2015-04-01

    Damage modelling is a key component in flood risk assessments. A conventional approach for estimating direct flood damages is the use of depth-damage functions. However, at present, there are few studies that describe in detail the parameters involved in the models and the hypotheses used for the development of these functions based on synthetic approaches and/or actual flood damage data. In this work a synthetic approach was adopted for the development of a damage model for residential buildings. The approach follows the loss assessment procedure usually applied by the insurance loss adjusters. Required information consisted of all those variables that are necessary to define hazard characteristics at building location, compute the exposure value of the building and the replacement costs of its components. In detail, the model requires four input tables. The hazard module includes the variables describing the features of the flood event at building location (e.g. water depth outside the building, water depth inside the basement, maximum velocity of the flood, duration of the event, contaminant and sediment load). The exposure module includes both extensive variables (e.g. foot print area, number of floors) and "vulnerability" variables, where the latter affect damage estimation in two different ways: by changing the replacement value/unit prices of the building and its components (e.g. the finishing level, building type) or by modifying the function(s) describing damage mechanisms (e.g. building structure, plant distribution). The replacement values table and the unit-price table include respectively the replacement value of the building and the unitary replacement costs of the different building components (e.g. doors and pavement replacement per square meter). The final output of the model is represented by different sets of damage functions describing all the building components (e.g. plasters, plants), depending on hazard, exposure and vulnerability characteristics. Such functions were developed using a what-if analysis using data collected after the 2012 flood in the Umbria Region in Central Italy, as well as authors' experience, as reference to understand damage mechanisms. Observed damage data were also used to calibrate the functions.

  20. Receiver Operating Characteristic (ROC) Curve Analysis for Medical Diagnostic Test Evaluation

    PubMed Central

    Hajian-Tilaki, Karimollah

    2013-01-01

    This review provides the basic principle and rational for ROC analysis of rating and continuous diagnostic test results versus a gold standard. Derived indexes of accuracy, in particular area under the curve (AUC) has a meaningful interpretation for disease classification from healthy subjects. The methods of estimate of AUC and its testing in single diagnostic test and also comparative studies, the advantage of ROC curve to determine the optimal cut off values and the issues of bias and confounding have been discussed. PMID:24009950

  1. The Modal Analysis of a Motorcycle in Straight Running and on a Curve

    Microsoft Academic Search

    V. Cossalter; R. Lot; F. Maggio

    2004-01-01

    The vibrational modes (generalized) of a two-wheel vehicle are studied in several trim configurations. The modal analysis is carried out on a 3D non-linear mathematical model, developed using the natural coordinates approach. A special procedure for evaluating the steady state solutions in straight running and on a curve is proposed. The paper presents detailed results of the modal analysis for

  2. Image-plane Analysis of n-Point-mass Lens Critical Curves and Caustics

    NASA Astrophysics Data System (ADS)

    Dan?k, Kamil; Heyrovský, David

    2015-06-01

    The interpretation of gravitational microlensing events caused by planetary systems or multiple stars is based on the n-point-mass lens model. The first planets detected by microlensing were well described by the two-point-mass model of a star with one planet. By the end of 2014, four events involving three-point-mass lenses had been announced. Two of the lenses were stars with two planetary companions each; two were binary stars with a planet orbiting one component. While the two-point-mass model is well understood, the same cannot be said for lenses with three or more components. Even the range of possible critical-curve topologies and caustic geometries of the three-point-mass lens remains unknown. In this paper we provide new tools for mapping the critical-curve topology and caustic cusp number in the parameter space of n-point-mass lenses. We perform our analysis in the image plane of the lens. We show that all contours of the Jacobian are critical curves of re-scaled versions of the lens configuration. Utilizing this property further, we introduce the cusp curve to identify cusp-image positions on all contours simultaneously. In order to track cusp-number changes in caustic metamorphoses, we define the morph curve, which pinpoints the positions of metamorphosis-point images along the cusp curve. We demonstrate the usage of both curves on simple two- and three-point-mass lens examples. For the three simplest caustic metamorphoses we illustrate the local structure of the image and source planes.

  3. Effects of variable recruitment on catch-curve analysis for crappie populations

    USGS Publications Warehouse

    Allen, M.S.

    1997-01-01

    Catch-curve analysis is frequently used to estimate total annual mortality (A) of exploited fishes, but the method assumes constant recruitment. Because populations of crappie Pomoxis spp. have exhibited large fluctuations in recruitment, I conducted simulations to assess the amount of variability in recruitment that precludes the use of a catch curve and compared results to recruitment dynamics in six crappie populations. Coefficients of variation (CV = 100 ?? SD/mean) in recruitment to age 1 ranged from 55% to 84% among the six crappie populations. Simulations suggested that recruitment variability in these ranges would likely allow estimation of A within ?? 10%, but the probability of obtaining estimates of A that were ??5% or more of the true A would exceed 0.15. I suggest that catch curves may be used to approximate A in crappie populations but that managers should consider the effects on management recommendations if A were ??10% of the estimated A.

  4. Algebra, Home Mortgages, and Recessions

    ERIC Educational Resources Information Center

    Mariner, Jean A. Miller; Miller, Richard A.

    2009-01-01

    The current financial crisis and recession in the United States present an opportunity to discuss relevant applications of some topics in typical first-and second-year algebra and precalculus courses. Real-world applications of percent change, exponential functions, and sums of finite geometric sequences can help students understand the problems…

  5. Mixed models defined by stochastic differential equations 1 Bayesian analysis of growth curves using mixed models defined by stochastic

    E-print Network

    Paris-Sud XI, Université de

    Mixed models defined by stochastic differential equations 1 Bayesian analysis of growth curves a parametric growth function, such as the Gompertz, logistic, Richards or Weibull functions (Zimmerman and N. In animal genetics, a wrong modeling of these curves could affect the genetic analysis. In fetal growth

  6. Induction Motor Fault Diagnosis Using a Hilbert-Park Lissajou's Curve Analysis and Neural Network-Based Decision

    E-print Network

    Paris-Sud XI, Université de

    Induction Motor Fault Diagnosis Using a Hilbert-Park Lissajou's Curve Analysis and Neural Network propose an original fault signature based on the Hilbert-Park Lissajou's curve analysis. The performances used. The proposed fault signature does not require a long temporal recording, and their processing

  7. A Cognitive Approach to Elementary School Recess

    ERIC Educational Resources Information Center

    Jones, Rose B.

    2005-01-01

    This article talks about the Cognitive Recess Curriculum as a cognitive approach to elementary school recess. The concept of a cognitive recess curriculum is based on three research studies conducted by the author. The largest study involved over 1,564 educators (superintendents, principals, teachers K 12). It sought to determine the subjects'…

  8. Modeling the Newtonian dynamics for rotation curve analysis of thin-disk galaxies

    NASA Astrophysics Data System (ADS)

    Feng, James Q.; Gallo, C. F.

    2011-12-01

    We present an efficient, robust computational method for modeling the Newtonian dynamics for rotation curve analysis of thin-disk galaxies. With appropriate mathematical treatments, the apparent numerical difficulties associated with singularities in computing elliptic integrals are completely removed. Using a boundary element discretization procedure, the governing equations are transformed into a linear algebra matrix equation that can be solved by straightforward Gauss elimination in one step without further iterations. The numerical code implemented according to our algorithm can accurately determine the surface mass density distribution in a disk galaxy from a measured rotation curve (or vice versa). For a disk galaxy with a typical flat rotation curve, our modeling results show that the surface mass density monotonically decreases from the galactic center toward the periphery, according to Newtonian dynamics. In a large portion of the galaxy, the surface mass density follows an approximately exponential law of decay with respect to the galactic radial coordinate. Yet the radial scale length for the surface mass density seems to be generally larger than that of the measured brightness distribution, suggesting an increasing mass-to-light ratio with the radial distance in a disk galaxy. In a nondimensionalized form, our mathematical system contains a dimensionless parameter which we call the “galactic rotation number" that represents the gross ratio of centrifugal force and gravitational force. The value of this galactic rotation number is determined as part of the numerical solution. Through a systematic computational analysis, we have illustrated that the galactic rotation number remains within ±10% of 1.70 for a wide variety of rotation curves. This implies that the total mass in a disk galaxy is proportional to V02Rg, with V0 denoting the characteristic rotation velocity (such as the “flat" value in a typical rotation curve) and Rg the radius of the galactic disk. The predicted total galactic mass of the Milky Way is in good agreement with the star-count data.

  9. Two kinds of C 0-type elements for buckling analysis of thin-walled curved beams

    Microsoft Academic Search

    N. Hu; B. Hu; B. Yan; H. Fukunaga; H. Sekine

    1999-01-01

    This paper deals with the spatial buckling analysis of curved beams. First, a second-order expansion for the finite rigid-rotations in nonlinear strain expressions is derived and employed to produce the geometric stiffness matrix. This second-order accurate geometric stiffness matrix can ensure that all significant instability modes can be predicted. Furthermore, Timoshenko's and Vlasov's beam theories are combined to develop two

  10. A shear deformable, doubly curved finite element for the analysis of laminated composite structures

    E-print Network

    Fuehne, Joseph Patrick

    1988-01-01

    for the degree of MASTER OF SCIENCE May 1988 Major Subject: Mechanical Engineering A SHEAR DEFORMABLE, DOUBLY CURVED FINITE ELEMENT FOR THE ANALYSIS OF LAMINATED COMPOSITE STRUCTURES A Thesis by JOSEPH PATRICK FUEHNE Approved as to style and content by... structures with complex curvature such as rotor or stator blades in a jet engine compressor. In this formulation, the constitutive equations are utilized to obtain in-plane layer stresses. With the in- plane stress variation established, the transverse...

  11. Analysis of free energy versus temperature curves in protein folding and macromolecular interactions.

    PubMed

    LiCata, Vince J; Liu, Chin-Chi

    2011-01-01

    Plots of free energy versus temperature are commonly called stability curves or Gibbs-Helmholtz curves, and they have proven to be extremely useful in protein folding and ligand-binding studies. Curvature in a Gibbs-Helmholtz or stability plot is indicative of a heat capacity change, and some of their primary uses in biochemistry over the past few decades have included determining ?Cp values and comparing ?Cp values between two related processes. This chapter describes basic approaches for analyzing curved Gibbs-Helmholtz plots, along with two specific extensions of standard Gibbs-Helmholtz plot analysis: (1) translating ?G of folding versus temperature into ?H and ?S versus temperature for comparing mesophilic-thermophilic protein pairs, and (2) fitting Gibbs-Helmholtz plots to determine if ?Cp changes with temperature or not. Neither of these extensions is new, but they are infrequently used, and their use is particularly germane to certain molecular interpretations of thermodynamic information from ?G versus temperature curves. It is shown that translating ?G of folding into ?H and ?S of folding versus temperature for a mesophilic-thermophilic protein pair can immediately influence possible structural hypotheses for thermal stabilization of thermophilic proteins. It is also shown that very small temperature-dependent heat capacity changes (??Cp values) can be obtained from extended fits to ?G versus temperature plots, and that these very small ??Cp values can have serious consequences for any attempt to correlate ?Cp with ?ASA for some reactions. PMID:21195230

  12. Autosomal Recessive Polycystic Kidney Disease

    Microsoft Academic Search

    Jodi M. Smith; Ruth A. McDonald

    \\u000a Autosomal recessive polycystic kidney disease (ARPKD) is an inherited disorder involving cystic dilatation of the renal collecting\\u000a ducts as well as varying degrees of hepatic abnormalities consisting of cysts, fibrosis, and portal hypertension. The ARPKD\\u000a locus has been mapped to chromosome 6p21 and encodes a novel protein product named fibrocystin or polyductin. There are several\\u000a modes of presentation depending on

  13. Recession, Retrenchment, and Recovery: State Higher Education Funding & Student Financial Aid. Volume II: State Profiles

    ERIC Educational Resources Information Center

    Ambrose, Allison S.; Hines, Edward R.; Hodel, Ross A.; Kelly, Kathleen F.; Mushrush, Christopher E., Pruden, Sheila J.; Vogt, W. Paul

    2006-01-01

    This report is a companion to "Recession, Retrenchment and Recovery: Higher Education Funding and Student Financial Aid" (ED502180). It provides profiles of individual states and their performance on a variety of measures used in the economic and fiscal analysis of the Recession, Retrenchment and Recovery project. The profiles describe the results…

  14. Robust mean traveltime curves: a powerful tool for analysis in 2D transmission tomographic surveys

    NASA Astrophysics Data System (ADS)

    Fernandez Martinez, J.; Pedruelo Gonzalez, L.; Rector, J.

    2008-12-01

    Acoustic tomography methods belong to the class of non destructive inspection techniques and are widely used in engineering applications. One of the main issues for these methods is the direct arrivals, which can be noisy or affected by scattering or other propagation effects. Mean traveltime curves (mean and standard deviation) have been introduced by Fernández Martínez et al (2006), and describe the variation of the main statistical parameters of the traveltime distribution for the different gathering subsets as a function of the gather index. These curves constitute a simple methodology (Fernández Martínez et al., 2008) to analyze before inversion the traveltime quality in 2D acoustic transmission tomography experiments conducted in relatively homogeneous blocks. This analysis can help to discriminate the contribution of picking errors from that of geological heterogeneities. In this contribution we present the so-called robust mean traveltime curves, which refer to the variation of the different p-percentiles and related measures of dispersion (inter-quartile range and minimum absolute deviation) for the above mentioned gathering subsets. Together with the mean curve, the median and upper-quartile traveltime curves are very resistant to the presence of outliers, and thus, are preferred to infer a background velocity model, which is valid at experiment scale and honors the experimental traveltime distribution. This methodology is valid for 2D zonal isotropic or elliptical anisotropic media, explored via any arbitrary acquisition geometry. We show the application to a well-known granitic medium (Febex Project, Nagra, Switzerland). Fernández Martínez et al. 2006. Mathematical Geology:38-3.343-374 Fernández Martínez et al.2008. Computer and Geosciences:34-3,213-225, 2008.

  15. Analysis of physical quality of soil using the water retention curve: validity of the S-index

    E-print Network

    Paris-Sud XI, Université de

    1 Analysis of physical quality of soil using the water retention curve: validity of the S Among the various soil indicators established in order to discuss physical properties of soils is the S the physical properties of soil using a water retention curve plotted with an arithmetic expression of suction

  16. Heterospecies partition analysis reveals binding curve and stoichiometry of protein interactions in living cells

    PubMed Central

    Wu, Bin; Chen, Yan; Müller, Joachim D.

    2010-01-01

    Measuring the binding curve and stoichiometry of protein complexes in living cells is a prerequisite for quantitative modeling of cellular processes. Dual-color fluorescence fluctuation spectroscopy provides a general framework for detecting protein interactions, but lacks suitable methods for quantifying protein heterointeractions in the cell. We address this challenge by introducing heterospecies partition (HSP) analysis for protein heterointeractions of the type D + nA?DAn. HSP directly identifies the heterointeracting species from the sample mixture and determines the binding curve and stoichiometry of the protein complex. The HSP method is applied to provide the first direct characterization of the ligand-dependent binding of the retinoic X receptor to the coactivator transcription intermediate factor 2. A previous study based on protein fragments observed a higher binding stoichiometry than biologically expected. We address this difference in stoichiometry by measuring the binding curves of the full-length proteins in living cells. This study provides proof-of-principle experiments that illustrate the potential of HSP as a general and robust analysis tool for the quantitative characterization of protein heterointeractions by dual-color fluorescence fluctuation spectroscopy in living cells. PMID:20142515

  17. Prediction of Cooling Curves for Squeeze Cast Al/SiCp Composites Using Finite Element Analysis

    NASA Astrophysics Data System (ADS)

    Gurusamy, P.; Balasivanandha Prabu, S.; Paskaramoorthy, R.

    2015-04-01

    This paper reports the experimental and finite element analyses of the solidification behavior of Al/SiCp composites, fabricated by the squeeze casting technique. Experiments were carried out by varying the melt temperatures for cylindrical-shaped composite castings. The composite samples were produced at the following constant temperatures: melt—1023 K, 1073 K, 1123 K, and 1173 K (750 °C, 800 °C, 850 °C, and 900 °C); and die—673 K (400 °C). The pressure applied throughout the experiment is 100 MPa. The melt temperature shows significant influence on the solidification behavior of the metal matrix composite. It was observed that the solidification time was 40 seconds when the melt temperature was 1023 K (750 °C) but it increased to 51 seconds when the melt temperature was at 1173 K (900 °C). The results also showed that the cooling rate decreased on increasing the melt temperature. Cooling curves for our system, squeeze cast composites, were predicted using the finite element software ANSYS. K-type thermocouples were interfaced to the die and the microcomputer from which the experimental cooling curves were constructed. The experimental and predicted cooling curves were then compared. While both show similar trends, the finite element analysis consistently under-predicts the temperature. In addition, finite element stress analysis reveals that both radial and tangential thermal stresses increase with the melt temperature.

  18. An elastic-plastic finite-element analysis of the J-resistance curve using a CTOD criterion

    NASA Technical Reports Server (NTRS)

    Newman, J. C., Jr.; Booth, B. C.; Shivakumar, K. N.

    1988-01-01

    The fracture process in compact and bend specimens was simulated using a two-dimensional finite-element analysis of the J-resistance (J-R) curve and a CTOD criterion. The J-R curves were calculated from the numerical results for each specimen type using several different methods. In general, the J-R curves obtained for the bend specimens were found to be higher than those for the compact specimens, especially beyond maximum load. However, below the maximum load, the modified deformation theory of plasticity and the contour-integral J(r) method resulted in very similar J-R curves for both specimen types.

  19. Periodic phenomena in Ae/Be Herbig stars light curves. I - Light curves classification and digital analysis methods. II - Results and probable interpretation for selected stars

    NASA Astrophysics Data System (ADS)

    Shevchenko, V. S.; Grankin, K. N.; Ibragimov, M. A.; Mel'Nikov, S. Yu.; Yakubov, S. D.

    1993-04-01

    Digital analysis methods are used to study the light curves of 78 Herbig Ae/Be stars. The mean epoch for a star is 5 yr. A morphological classification of the light curves is proposed. The digital analysis method is briefly described. To estimate the reliability of the cyclic phenomena discovered in the present study, a large number of them are examined. Three types of cyclic phenomena are identified and discussed. These phenomena are interpreted in terms of Keplerian rotation of various structures in accretion disks and formations. The hypothesis of giant protocomets is suggested to explain P(0) periods. Short-period cyclicity is associated with the variation of hot compact shell shapes modulated by rotation.

  20. Improved protocol for rapid identification of certain spa types using high resolution melting curve analysis.

    PubMed

    Mayerhofer, Benjamin; Stöger, Anna; Pietzka, Ariane T; Fernandez, Haizpea Lasa; Prewein, Bernhard; Sorschag, Sieglinde; Kunert, Renate; Allerberger, Franz; Ruppitsch, Werner

    2015-01-01

    Methicillin-resistant Staphylococcus aureus is one of the most significant pathogens associated with health care. For efficient surveillance, control and outbreak investigation, S. aureus typing is essential. A high resolution melting curve analysis was developed and evaluated for rapid identification of the most frequent spa types found in an Austrian hospital consortium covering 2,435 beds. Among 557 methicillin-resistant Staphylococcus aureus isolates 38 different spa types were identified by sequence analysis of the hypervariable region X of the protein A gene (spa). Identification of spa types through their characteristic high resolution melting curve profiles was considerably improved by double spiking with genomic DNA from spa type t030 and spa type t003 and allowed unambiguous and fast identification of the ten most frequent spa types t001 (58%), t003 (12%), t190 (9%), t041 (5%), t022 (2%), t032 (2%), t008 (2%), t002 (1%), t5712 (1%) and t2203 (1%), representing 93% of all isolates within this hospital consortium. The performance of the assay was evaluated by testing samples with unknown spa types from the daily routine and by testing three different high resolution melting curve analysis real-time PCR instruments. The ten most frequent spa types were identified from all samples and on all instruments with 100% specificity and 100% sensitivity. Compared to classical spa typing by sequence analysis, this gene scanning assay is faster, cheaper and can be performed in a single closed tube assay format. Therefore it is an optimal screening tool to detect the most frequent endemic spa types and to exclude non-endemic spa types within a hospital. PMID:25768007

  1. Multivariate Analysis of the Ocular Response Analyzer's Corneal Deformation Response Curve for Early Keratoconus Detection

    PubMed Central

    Galletti, Jonatán D.; Ruiseñor Vázquez, Pablo R.; Fuentes Bonthoux, Fernando; Pförtner, Tomás; Galletti, Jeremías G.

    2015-01-01

    Purpose. To thoroughly analyze corneal deformation responses curves obtained by Ocular Response Analyzer (ORA) testing in order to improve subclinical keratoconus detection. Methods. Observational case series of 87 control and 73 subclinical keratoconus eyes. Examination included corneal topography, tomography, and biomechanical testing with ORA. Factor analysis, logistic regression, and receiver operating characteristic curves were used to extract combinations of 45 corneal waveform descriptors. Main outcome measures were corneal-thickness-corrected corneal resistance factor (ccCRF), combinations of corneal descriptors, and their diagnostic performance. Results. Thirty-seven descriptors differed significantly in means between groups, and among them ccCRF afforded the highest individual diagnostic performance. Factor analysis identified first- and second-peak related descriptors as the most variable one. However, conventional biomechanical descriptors corneal resistance factor and hysteresis differed the most between control and keratoconic eyes. A combination of three factors including several corneal descriptors did not show better diagnostic performance than a combination of conventional indices. Conclusion. Multivariate analysis of ORA signals did not surpass simpler models in subclinical keratoconus detection, and there is considerable overlap between normal and ectatic eyes irrespective of the analysis model. Conventional biomechanical indices seem to already provide the best performance when appropriately considered.

  2. Multivariate Analysis of the Ocular Response Analyzer's Corneal Deformation Response Curve for Early Keratoconus Detection.

    PubMed

    Galletti, Jonatán D; Ruiseñor Vázquez, Pablo R; Fuentes Bonthoux, Fernando; Pförtner, Tomás; Galletti, Jeremías G

    2015-01-01

    Purpose. To thoroughly analyze corneal deformation responses curves obtained by Ocular Response Analyzer (ORA) testing in order to improve subclinical keratoconus detection. Methods. Observational case series of 87 control and 73 subclinical keratoconus eyes. Examination included corneal topography, tomography, and biomechanical testing with ORA. Factor analysis, logistic regression, and receiver operating characteristic curves were used to extract combinations of 45 corneal waveform descriptors. Main outcome measures were corneal-thickness-corrected corneal resistance factor (ccCRF), combinations of corneal descriptors, and their diagnostic performance. Results. Thirty-seven descriptors differed significantly in means between groups, and among them ccCRF afforded the highest individual diagnostic performance. Factor analysis identified first- and second-peak related descriptors as the most variable one. However, conventional biomechanical descriptors corneal resistance factor and hysteresis differed the most between control and keratoconic eyes. A combination of three factors including several corneal descriptors did not show better diagnostic performance than a combination of conventional indices. Conclusion. Multivariate analysis of ORA signals did not surpass simpler models in subclinical keratoconus detection, and there is considerable overlap between normal and ectatic eyes irrespective of the analysis model. Conventional biomechanical indices seem to already provide the best performance when appropriately considered. PMID:26075085

  3. 3D combinational curves for accuracy and performance analysis of positive biometrics identification

    NASA Astrophysics Data System (ADS)

    Du, Yingzi; Chang, Chein-I.

    2008-06-01

    The receiver operating characteristic (ROC) curve has been widely used as an evaluation criterion to measure the accuracy of biometrics system. Unfortunately, such an ROC curve provides no indication of the optimum threshold and cost function. In this paper, two kinds of 3D combinational curves are proposed: the 3D combinational accuracy curve and the 3D combinational performance curve. The 3D combinational accuracy curve gives a balanced view of the relationships among FAR (false alarm rate), FRR (false rejection rate), threshold t, and Cost. Six 2D curves can be derived from the 3D combinational accuracy curve: the conventional 2D ROC curve, 2D curve of (FRR, t), 2D curve of (FAR, t), 2D curve of (FRR, Cost), 2D curve of (FAR, Cost), and 2D curve of ( t, Cost). The 3D combinational performance curve can be derived from the 3D combinational accuracy curve which can give a balanced view among Security, Convenience, threshold t, and Cost. The advantages of using the proposed 3D combinational curves are demonstrated by iris recognition systems where the experimental results show that the proposed 3D combinational curves can provide more comprehensive information of the system accuracy and performance.

  4. Spectrophotometric analysis of gamma-ray burst afterglow extinction curves with X-Shooter

    NASA Astrophysics Data System (ADS)

    Japelj, J.; Covino, S.; Gomboc, A.; Vergani, S. D.; Goldoni, P.; Selsing, J.; Cano, Z.; D'Elia, V.; Flores, H.; Fynbo, J. P. U.; Hammer, F.; Hjorth, J.; Jakobsson, P.; Kaper, L.; Kopa?, D.; Krühler, T.; Melandri, A.; Piranomonte, S.; Sánchez-Ramírez, R.; Tagliaferri, G.; Tanvir, N. R.; de Ugarte Postigo, A.; Watson, D.; Wijers, R. A. M. J.

    2015-07-01

    We use gamma-ray burst (GRB) afterglow spectra observed with the VLT/X-Shooter spectrograph to measure rest-frame extinction in GRB lines-of-sight by modelling the broadband near-infrared (NIR) to X-ray afterglow spectral energy distributions (SEDs). Our sample consists of nine Swift GRBs, of which eight belong to the long-duration and one to the short-duration class. Dust is modelled using the average extinction curves of the Milky Way and the two Magellanic Clouds. We derive the rest-frame extinction of the entire sample, which fall in the range 0 ? AV ? 1.2. Moreover, the SMC extinction curve is the preferred extinction curve template for the majority of our sample, a result that is in agreement with those commonly observed in GRB lines of sights. In one analysed case (GRB 120119A), the common extinction curve templates fail to reproduce the observed extinction. To illustrate the advantage of using the high-quality, X-Shooter afterglow SEDs over the photometric SEDs, we repeat the modelling using the broadband SEDs with the NIR-to-UV photometric measurements instead of the spectra. The main result is that the spectroscopic data, thanks to a combination of excellent resolution and coverage of the blue part of the SED, are more successful in constraining extinction curves and therefore dust properties in GRB hosts with respect to photometric measurements. In all cases but one the extinction curve of one template is preferred over the others. We show that themodelled values of the extinction AV and the spectral slope, obtained through spectroscopic and photometric SED analysis, can differ significantly for individual events, though no apparent trend in the differences is observed. Finally we stress that, regardless of the resolution of the optical-to-NIR data, the SED modelling gives reliable results only when the fit is performed on a SED covering a broader spectral region (in our case extending to X-rays). Based on observations collected at the European Southern Observatory, Paranal, Chile, under programs 084.A-0260(B), 085.A-0009(B), 088.A-0051(B), 089.A-0067(B) and 091.C-0934(C).Appendix A is available in electronic form at http://www.aanda.org

  5. Modeling and regression analysis of semiochemical dose-response curves of insect antennal reception and behavior.

    PubMed

    Byers, John A

    2013-08-01

    Dose-response curves of the effects of semiochemicals on neurophysiology and behavior are reported in many articles in insect chemical ecology. Most curves are shown in figures representing points connected by straight lines, in which the x-axis has order of magnitude increases in dosage vs. responses on the y-axis. The lack of regression curves indicates that the nature of the dose-response relationship is not well understood. Thus, a computer model was developed to simulate a flux of various numbers of pheromone molecules (10(3) to 5 × 10(6)) passing by 10(4) receptors distributed among 10(6) positions along an insect antenna. Each receptor was depolarized by at least one strike by a molecule, and subsequent strikes had no additional effect. The simulations showed that with an increase in pheromone release rate, the antennal response would increase in a convex fashion and not in a logarithmic relation as suggested previously. Non-linear regression showed that a family of kinetic formation functions fit the simulated data nearly perfectly (R(2) >0.999). This is reasonable because olfactory receptors have proteins that bind to the pheromone molecule and are expected to exhibit enzyme kinetics. Over 90 dose-response relationships reported in the literature of electroantennographic and behavioral bioassays in the laboratory and field were analyzed by the logarithmic and kinetic formation functions. This analysis showed that in 95% of the cases, the kinetic functions explained the relationships better than the logarithmic (mean of about 20% better). The kinetic curves become sigmoid when graphed on a log scale on the x-axis. Dose-catch relationships in the field are similar to dose-EAR (effective attraction radius, in which a spherical radius indicates the trapping effect of a lure) and the circular EARc in two dimensions used in mass trapping models. The use of kinetic formation functions for dose-response curves of attractants, and kinetic decay curves for inhibitors, will allow more accurate predictions of insect catch in monitoring and control programs. PMID:23897111

  6. 6.RP Games at Recess

    NSDL National Science Digital Library

    This is a task from the Illustrative Mathematics website that is one part of a complete illustration of the standard to which it is aligned. Each task has at least one solution and some commentary that addresses important asects of the task and its potential use. Here are the first few lines of the commentary for this task: The students in Mr. Hill’s class played games at recess. $\\hskip30pt$6 boys played soccer $\\hskip30pt$4 girls played soccer $\\hskip30pt$2 boys jumped r...

  7. Pg 1115+080: New Analysis of the Light Curves Confirms Old Time Delay Results

    NASA Astrophysics Data System (ADS)

    Artamonov, B.; Koptelova, E.; Oknyanskij, V.; Shimanovskaya, E.

    We analyze all publicly available long-term optical observations of the gravitationally lensed quasar PG1115+080 with the aim of measuring time delays between its four components. In particular, we present analysis of the Maidanak light curves of the PG1115+080 components obtained between 2001 and 2006 (Tsvetkova et al. 2010). We find that the light curves of the 2006 observational season show almost linear trend with some fast variations seen only in the A1 and C components. This can be as due to microlensing or observational errors. These fast variations can decrease statistical significance of the time delay estimates or even produce misleading results. Application of the MCCF technique (Oknyanskij 1993) to photometric data collected in the 2004-2005 seasons gives time delay values tBC = 22±3, tAC = 12±3, and tBA = 10±3 days, which are in agreement with previous results of Schechter et al. (1997) and Barkana (1997) reported for the 1995-1996 light curves analyzed using two different statistical methods. The ratio tAC/tBA between our intermediate delays is about 1.2 that is close to the value reported by Barkana ( ?1.13) and predicted by lens models (?1.4) unlike the Schechter's and Vakulik's (2009) values (? 0.7 and ?2.7).

  8. Image-plane Analysis of n-point-mass Lens Critical Curves and Caustics

    E-print Network

    Danek, Kamil

    2015-01-01

    The interpretation of gravitational microlensing events caused by planetary systems or multiple stars is based on the n-point mass lens model. The first planets detected by microlensing were well described by the two-point-mass model of a star with one planet. By the end of 2014, four events involving three-point-mass lenses had been announced. Two of the lenses were stars with two planetary companions each; two were binary stars with a planet orbiting one component. While the two-point-mass model is well understood, the same cannot be said for lenses with three or more components. Even the range of possible critical-curve topologies and caustic geometries of the three-point-mass lens remains unknown. In this paper we provide new tools for mapping the critical-curve topology and caustic cusp number in the parameter space of n-point-mass lenses. We perform our analysis in the image plane of the lens. We show that all contours of the Jacobian are critical curves of re-scaled versions of the lens configuration. ...

  9. Kinematic analysis of the technique for elite male long-distance speed skaters in curving.

    PubMed

    Juda, Jun; Yuki, Masahiro; Aoyanagi, Toru; Fujii, Norihisa; Ae, Michiyoshi

    2007-05-01

    The purpose of this study was to investigate technical factors for maintaining skating velocity by kinematic analysis of the skating motion for elite long-distance skaters during the curve phase in official championship races. Sixteen world-class elite male skaters who participated in the 5,000-m race were videotaped with two synchronized high-speed video cameras (250 Hz) in a curve lane by using a panning DLT technique. Three-dimensional coordinates of the body and blades during the first and second halves of the races were collected to calculate kinematic parameters. In the group that maintained greater skating velocity, the thigh angle during the gliding phase of the left stroke during the second half was greater than that during the first half, and the center of mass was located more forward during the second half. Thus, it was suggested that long-distance speed skaters should change the support leg position during the gliding phase in the left stroke of the curve phase under fatigued conditions so that they could extend the support leg with a forward rotation of the thigh and less shank backward rotation. PMID:17603132

  10. Analysis of a Curved Interfacial Crack Between Viscoelastic Foam and Anisotropic Composites Under Antiplane Shear

    NASA Astrophysics Data System (ADS)

    Chun, Heoung Jae; Park, Sang Hyun

    The analysis of curved interfacial crack between viscoelastic foam and anisotropic composites was conducted under antiplane shear loading applied at infinity. In the analysis, in order to represent viscoelastic behavior of foam, the Kelvin-Maxwell model was incorporated and Laplace transform was applied to treat the viscoelastic characteristics of foam. The curved interfacial crack problem was reduced to a Hilbert problem and a closed-form asymptotic solution was derived. The stress intensity factors in the vicinity of the interfacial crack tip were predicted by considering both anisotropic characteristics of composites and viscoelastic properties of foam. It was found from the analysis that the stress intensity factor was governed by material properties such as shear modulus and relaxation time, and increased with the increase in the curvature as well as the ratio of stiffness coefficients of composite materials. It was also observed that the effect of fiber orientation in the composite materials on the stress intensity factor decreased with the increase in the difference in stiffness coefficients between foam and composite.

  11. Optimized curve design for image analysis using localized geodesic distance transformations

    NASA Astrophysics Data System (ADS)

    Braithwaite, Billy; Niska, Harri; Pöllänen, Irene; Ikonen, Tiia; Haataja, Keijo; Toivanen, Pekka; Tolonen, Teemu

    2015-03-01

    We consider geodesic distance transformations for digital images. Given a M × N digital image, a distance image is produced by evaluating local pixel distances. Distance Transformation on Curved Space (DTOCS) evaluates shortest geodesics of a given pixel neighborhood by evaluating the height displacements between pixels. In this paper, we propose an optimization framework for geodesic distance transformations in a pattern recognition scheme, yielding more accurate machine learning based image analysis, exemplifying initial experiments using complex breast cancer images. Furthermore, we will outline future research work, which will complete the research work done for this paper.

  12. Determining the nucleation rate curve for lithium disilicate glass by differential thermal analysis

    NASA Technical Reports Server (NTRS)

    Ray, Chandra S.; Day, Delbert E.

    1990-01-01

    The crystallization of lithium disilicate (Li2O+2SiO2) glass nucleated at various temperatures was studied by differential thermal analysis (DTA). A plot of the DTA crystallization peak height versus nucleation temperature closely resembles the classical nucleation rate curve for lithium disilicate glass whose maximum is at 453 C. The glass becomes saturated with internal nuclei when heated at 453 C for 10 h. The activation energy for crystallization and the heat of crystallization are independent of the concentration of nuclei and are 249 + or - 10 and 67 + or - 3 kJ/mol, respectively. The Avrami exponent, n, depends strongly on the concentration of nuclei in the glass.

  13. Evaluation of the formation of a junctional DNA nanostructure through annealing curve analysis.

    PubMed

    Shin, Seung Won; Park, Kyung Soo; Um, Soong Ho

    2015-02-20

    During the self-assembly of different numbers of oligonucleotides comprising junctional DNA nanostructures, a change in environmental variables (e.g., temperature or salt concentration) has a substantial influence on the final products. Further, distinctive annealing temperatures of oligonucleotides are observed depending on the state of hybridization. Here, we present an evaluation of the annealing characteristics of oligonucleotides for the formation of a simple junctional DNA nanostructure using an annealing curve analysis. This method may be useful for analyzing the formation of complex junctional DNA nanostructures. PMID:25597993

  14. Recessively transmitted predominantly motor neuropathies.

    PubMed

    Parman, Ye?im; Battalo?lu, Esra

    2013-01-01

    Recessively transmitted predominantly motor neuropathies are rare and show a severe phenotype. They are frequently observed in populations with a high rate of consanguineous marriages. At least 15 genes and six loci have been found to be associated with autosomal recessive CMT (AR-CMT) and X-linked CMT (AR-CMTX) and also distal hereditary motor neuronopathy (AR-dHMN). These disorders are genetically heterogeneous but the clinical phenotype is relatively homogeneous. Distal muscle weakness and atrophy predominating in the lower extremities, diminished or absent deep tendon reflexes, distal sensory loss, and pes cavus are the main clinical features of this disorder with occasional cranial nerve involvement. Although genetic diagnosis of some of subtypes of AR-CMT are now available, rapid advances in the molecular genetics and cell biology show a great complexity. Animal models for the most common subtypes of human AR-CMT disease provide clues for understanding the pathogenesis of CMT and also help to reveal possible treatment strategies of inherited neuropathies. This chapter highlights the clinical features and the recent genetic and biological findings in these disorders based on the current classification. PMID:23931818

  15. On the Analysis and Construction of the Butterfly Curve Using "Mathematica"[R

    ERIC Educational Resources Information Center

    Geum, Y. H.; Kim, Y. I.

    2008-01-01

    The butterfly curve was introduced by Temple H. Fay in 1989 and defined by the polar curve r = e[superscript cos theta] minus 2 cos 4 theta plus sin[superscript 5] (theta divided by 12). In this article, we develop the mathematical model of the butterfly curve and analyse its geometric properties. In addition, we draw the butterfly curve and…

  16. Nonlinear Analysis and Post-Test Correlation for a Curved PRSEUS Panel

    NASA Technical Reports Server (NTRS)

    Gould, Kevin; Lovejoy, Andrew E.; Jegley, Dawn; Neal, Albert L.; Linton, Kim, A.; Bergan, Andrew C.; Bakuckas, John G., Jr.

    2013-01-01

    The Pultruded Rod Stitched Efficient Unitized Structure (PRSEUS) concept, developed by The Boeing Company, has been extensively studied as part of the National Aeronautics and Space Administration's (NASA s) Environmentally Responsible Aviation (ERA) Program. The PRSEUS concept provides a light-weight alternative to aluminum or traditional composite design concepts and is applicable to traditional-shaped fuselage barrels and wings, as well as advanced configurations such as a hybrid wing body or truss braced wings. Therefore, NASA, the Federal Aviation Administration (FAA) and The Boeing Company partnered in an effort to assess the performance and damage arrestments capabilities of a PRSEUS concept panel using a full-scale curved panel in the FAA Full-Scale Aircraft Structural Test Evaluation and Research (FASTER) facility. Testing was conducted in the FASTER facility by subjecting the panel to axial tension loads applied to the ends of the panel, internal pressure, and combined axial tension and internal pressure loadings. Additionally, reactive hoop loads were applied to the skin and frames of the panel along its edges. The panel successfully supported the required design loads in the pristine condition and with a severed stiffener. The panel also demonstrated that the PRSEUS concept could arrest the progression of damage including crack arrestment and crack turning. This paper presents the nonlinear post-test analysis and correlation with test results for the curved PRSEUS panel. It is shown that nonlinear analysis can accurately calculate the behavior of a PRSEUS panel under tension, pressure and combined loading conditions.

  17. Antigen-antibody biorecognition events as discriminated by noise analysis of force spectroscopy curves

    NASA Astrophysics Data System (ADS)

    Bizzarri, Anna Rita; Cannistraro, Salvatore

    2014-08-01

    Atomic force spectroscopy is able to extract kinetic and thermodynamic parameters of biomolecular complexes provided that the registered unbinding force curves could be reliably attributed to the rupture of the specific complex interactions. To this aim, a commonly used strategy is based on the analysis of the stretching features of polymeric linkers which are suitably introduced in the biomolecule-substrate immobilization procedure. Alternatively, we present a method to select force curves corresponding to specific biorecognition events, which relies on a careful analysis of the force fluctuations of the biomolecule-functionalized cantilever tip during its approach to the partner molecules immobilized on a substrate. In the low frequency region, a characteristic 1/f ? noise with ? equal to one (flickering noise) is found to replace white noise in the cantilever fluctuation power spectrum when, and only when, a specific biorecognition process between the partners occurs. The method, which has been validated on a well-characterized antigen-antibody complex, represents a fast, yet reliable alternative to the use of linkers which may involve additional surface chemistry and reproducibility concerns.

  18. Recess physical activity and perceived school environment among elementary school children.

    PubMed

    Ishii, Kaori; Shibata, Ai; Sato, Mai; Oka, Koichiro

    2014-07-01

    Differences in recess physical activity (PA) according to perceived school environment among elementary school children were examined. Participants were 103 children from two schools in Japan. PA was measured using accelerometry for seven consecutive days. Time spent in sedentary or PA (light, moderate, or vigorous) during their morning recess (25 min) and lunch recess (15 min) was determined. The School Physical Activity Environment Scale (three factors: equipment, facility, and safety) was used to investigate perceived school environment. Environmental factor scores were assigned to low or high groups for each factor by median. An analysis of covariance, with grade as the covariate, was conducted separately by gender to examine differences in PA between two groups. During lunch recess, boys in the high-equipment group spent significantly more time in moderate PA (high: 1.5; low: 0.8 min) whereas girls in this group spent less time in light PA (9.3, 11.0). Boys in the high-facility group spent significantly less time in sedentary (2.3, 3.9) and more time in vigorous PA (2.4, 1.4) during lunch recess, and girls spent more time in moderate (2.1, 1.2) and vigorous PA (1.9, 1.3) during morning recess. Differences were observed in recess PA according to school environment perceptions. The present study may be useful for further intervention studies for the promotion of PA during recess. PMID:25029495

  19. Buckling analysis of curved composite sandwich panels subjected to inplane loadings

    NASA Technical Reports Server (NTRS)

    Cruz, Juan R.

    1993-01-01

    Composite sandwich structures are being considered for primary structure in aircraft such as subsonic and high speed civil transports. The response of sandwich structures must be understood and predictable to use such structures effectively. Buckling is one of the most important response mechanisms of sandwich structures. A simple buckling analysis is derived for sandwich structures. This analysis is limited to flat, rectangular sandwich panels loaded by uniaxial compression (N(sub x)) and having simply supported edges. In most aerospace applications, however, the structure's geometry, boundary conditions, and loading are usually very complex. Thus, a general capability for analyzing the buckling behavior of sandwich structures is needed. The present paper describes and evaluates an improved buckling analysis for cylindrically curved composite sandwich panels. This analysis includes orthotropic facesheets and first-order transverse shearing effects. Both simple support and clamped boundary conditions are also included in the analysis. The panels can be subjected to linearly varying normal loads N(sub x) and N(sub y) in addition to a constant shear load N(sub xy). The analysis is based on the modified Donnell's equations for shallow shells. The governing equations are solved by direct application of Galerkin's method. The accuracy of the present analysis is verified by comparing results with those obtained from finite element analysis for a variety of geometries, loads, and boundary conditions. The limitations of the present analysis are investigated, in particular those related to the shallow shell assumptions in the governing equations. Finally, the computational efficiency of the present analysis is considered.

  20. Cooling Curve Analysis as an Alternative to Dilatometry in Continuous Cooling Transformations

    NASA Astrophysics Data System (ADS)

    Gibbs, John W.; Schlacher, Christian; Kamyabi-Gol, Ata; Mayr, Peter; Mendez, Patricio F.

    2015-01-01

    Dilatometry and cooling curve analysis (CCA) are two methods of determining the evolution of a phase transformation with temperature. The two methods are similar conceptual in that they take an indirect measure of the transformation and extract phase fraction information from it; however, the differences between the two methods typically makes one method better suited to analyzing a given transformation. However, without a quantitative comparison between the two methods, it is difficult to use them interchangeably. We address this by presenting a quantitative comparison of CCA and dilatometry for a martensitic transformation in a 9Cr3W3CoVNb steel. The resulting phase fraction data matches very well, within 5 K (5 °C) for any given phase fraction. This paper also extends to the quantitative methodology of calorimetry to the analysis of dilatometric data, with results comparable to ASTM A1033-10, but with expected higher accuracy by accounting by variable thermal expansion coefficients.

  1. Recess for Elementary School Students. Position Statement

    ERIC Educational Resources Information Center

    National Association for Sport and Physical Education, 2006

    2006-01-01

    It is the position of the National Association for Sport and Physical Education (NASPE) that all elementary school children should be provided with at least one daily period of recess of at least 20 minutes in length. Recess is an essential component of a comprehensive school physical activity program and of the total education experience for…

  2. Precession and Recession of the Rock'n'roller

    E-print Network

    Peter Lynch; Miguel D. Bustamante

    2009-07-09

    We study the dynamics of a spherical rigid body that rocks and rolls on a plane under the effect of gravity. The distribution of mass is non-uniform and the centre of mass does not coincide with the geometric centre. The symmetric case, with moments of inertia I_1=I_2, is integrable and the motion is completely regular. Three known conservation laws are the total energy E, Jellett's quantity Q_J and Routh's quantity Q_R. When the inertial symmetry I_1=I_2 is broken, even slightly, the character of the solutions is profoundly changed and new types of motion become possible. We derive the equations governing the general motion and present analytical and numerical evidence of the recession, or reversal of precession, that has been observed in physical experiments. We present an analysis of recession in terms of critical lines dividing the (Q_R,Q_J) plane into four dynamically disjoint zones. We prove that recession implies the lack of conservation of Jellett's and Routh's quantities, by identifying individual reversals as crossings of the orbit (Q_R(t),Q_J(t)) through the critical lines. Consequently, a method is found to produce a large number of initial conditions so that the system will exhibit recession.

  3. Free vibration analysis of point-supported laminated composite doubly curved shells—A finite element approach

    Microsoft Academic Search

    D. Chakravorty; J. N. Bandyopadhyay; P. K. Sinha

    1995-01-01

    A finite element analysis for studying the free vibration behaviour of generalized doubly curved laminated composite shells is presented using eight-noded curved quadrilateral isoparametric finite elements. The formulation assumes first-order shear deformation theory for thin and shallow shells, and also considers the two principal radii of curvature and the radius of cross-curvature. Some of the results obtained are compared with

  4. Genetics Home Reference: Autosomal recessive axonal neuropathy with neuromyotonia

    MedlinePLUS

    ... OMIM Genetic disorder catalog Conditions > Autosomal recessive axonal neuropathy with neuromyotonia On this page: Description Genetic changes ... Reviewed September 2014 What is autosomal recessive axonal neuropathy with neuromyotonia? Autosomal recessive axonal neuropathy with neuromyotonia ...

  5. High-throughput analysis of molecular orientation on surfaces by NEXAFS imaging of curved sample arrays.

    PubMed

    Baio, Joe E; Jaye, Cherno; Fischer, Daniel A; Weidner, Tobias

    2014-09-01

    Near-edge X-ray absorption fine structure (NEXAFS) spectroscopy provides detailed information about the orientation and alignment of thin films. NEXAFS is a synchrotron-based technique-the availability of beam-time per user is typically limited to no more than a few weeks per year. The limited availability is currently a true barrier for using NEXAFS in combinatorial studies of molecular alignment. We have recently demonstrated how large area full field NEXAFS imaging allows users to pursue combinatorial studies of surface chemistry. Now we report an extension of this approach which allows the acquisition of orientation information from a single NEXAFS image. An array with 80 elements (samples), containing eight series of different surface modifications, was mounted on a curved substrate allowing the collection of NEXAFS spectra with a range of orientations with respect to the X-ray beam. Images collected from this array show how hyperspectral NEXAFS data collected from curved surfaces can be used for high-throughput molecular orientation analysis. PMID:25046426

  6. Prevalence of Helicobacter pylori in symptomatic patients and detection of clarithromycin resistance using melting curve analysis

    PubMed Central

    Kaya, Ayse Demet; Öztürk, C. Elif; Akcan, Yusuf; Behçet, Mustafa; Karakoç, A. Esra; Yücel, Mihriban; M?s?rl?oglu, Müge; Tuncer, Serdar

    2007-01-01

    Abstract Background: Clarithromycin is often a component of combination therapies for Helicobacter pylori eradication; however, increases in resistance rates have decreased the success of the treatment. Objective: This study was designed to determine the prevalence of H pylori infection in symptomatic patients and to detect clarithromycin resistance rates using melting curve analysis. Methods: Patients scheduled for upper endoscopy at the Endoscopy Unit of the Department of Gastroenterology, Duzce University, Medical Faculty Hospital, Konuralp/Duzce, Turkey, were assessed for enrollment in the study. Two pairs of gastric biopsy specimens (antrum and corpus) were obtained from each study patient. Histopathologic examination, rapid urease test, culture, and polymerase chain reaction (PCR) of the specimens were used to identify H pylori infection. Clarithromycin resistance was detected using melting curve analysis. Results: Seventy-five patients (41 women, 34 men; mean [SD]age, 42.6 [14.5] years [range, 17–70 years]) were included in the study. Using histopathology and rapid urease test, H pylori was detected in 40 (53.3%) of the 75 specimens. H pylori was detected using PCR in 40 (53.3%) specimens and by culture in 10 (13.3%) specimens. The specificity and sensitivity of PCR and culture were interpreted by comparing them with the results of histopathologic examination and urease tests. The specificity and sensitivity of PCR were 68.6% and 72.5%, respectively, and the specificity and sensitivity of culture were 97.1% and 22.5%, respectively. Of the 40 isolates, 21 (52.5%) were susceptible to clarithromycin, 12 (30.0%) were resistant, and a mixed susceptibility pattern was detected in 7 (17.5%) specimens. H pylori isolates from 19 (79.2%) of the 24 patients who had formerly used clarithromycin showed clarithromycin resistance. Conclusions: The prevalence of H pylori infection was 53.3% for the symptomatic patients in this study, and 47.5% of the isolates showed clarithromycin resistance using melting curve analysis. The PCR-based system used in this study was accurate for the detection of H pylori infection as well as clarithromycin susceptibility testing directly in biopsy specimens. PMID:24683206

  7. [Application of calibration curve method and partial least squares regression analysis to quantitative analysis of nephrite samples using XRF].

    PubMed

    Liu, Song; Su, Bo-min; Li, Qing-hui; Gan, Fu-xi

    2015-01-01

    The authors tried to find a method for quantitative analysis using pXRF without solid bulk stone/jade reference samples. 24 nephrite samples were selected, 17 samples were calibration samples and the other 7 are test samples. All the nephrite samples were analyzed by Proton induced X-ray emission spectroscopy (PIXE) quantitatively. Based on the PIXE results of calibration samples, calibration curves were created for the interested components/elements and used to analyze the test samples quantitatively; then, the qualitative spectrum of all nephrite samples were obtained by pXRF. According to the PIXE results and qualitative spectrum of calibration samples, partial least square method (PLS) was used for quantitative analysis of test samples. Finally, the results of test samples obtained by calibration method, PLS method and PIXE were compared to each other. The accuracy of calibration curve method and PLS method was estimated. The result indicates that the PLS method is the alternate method for quantitative analysis of stone/jade samples. PMID:25993858

  8. Multivariate curve resolution for hyperspectral image analysis :applications to microarray technology.

    SciTech Connect

    Van Benthem, Mark Hilary; Sinclair, Michael B.; Haaland, David Michael; Martinez, M. Juanita (University of New Mexico, Albuquerque, NM); Timlin, Jerilyn Ann; Werner-Washburne, Margaret C. (University of New Mexico, Albuquerque, NM); Aragon, Anthony D. (University of New Mexico, Albuquerque, NM)

    2003-01-01

    Multivariate curve resolution (MCR) using constrained alternating least squares algorithms represents a powerful analysis capability for a quantitative analysis of hyperspectral image data. We will demonstrate the application of MCR using data from a new hyperspectral fluorescence imaging microarray scanner for monitoring gene expression in cells from thousands of genes on the array. The new scanner collects the entire fluorescence spectrum from each pixel of the scanned microarray. Application of MCR with nonnegativity and equality constraints reveals several sources of undesired fluorescence that emit in the same wavelength range as the reporter fluorphores. MCR analysis of the hyperspectral images confirms that one of the sources of fluorescence is due to contaminant fluorescence under the printed DNA spots that is spot localized. Thus, traditional background subtraction methods used with data collected from the current commercial microarray scanners will lead to errors in determining the relative expression of low-expressed genes. With the new scanner and MCR analysis, we generate relative concentration maps of the background, impurity, and fluorescent labels over the entire image. Since the concentration maps of the fluorescent labels are relatively unaffected by the presence of background and impurity emissions, the accuracy and useful dynamic range of the gene expression data are both greatly improved over those obtained by commercial microarray scanners.

  9. Single-channel multiplexing without melting curve analysis in real-time PCR

    PubMed Central

    Lee, Young-Jo; Kim, Daeyoung; Lee, Kihoon; Chun, Jong-Yoon

    2014-01-01

    Multiplex real-time PCR with quantification of targets in a single fluorescence channel has been the demand in biotechnology industry. Here, we develop a novel analytical real-time PCR technique to detect multiple targets in a single fluorescence channel without melting curve analysis. In this technique, we show the intensity of the fluorescence signals of two discrete Tm targets is different at certain temperatures called detection temperatures, by which a high Tm target can be detected regardless of a low Tm target. We then identify the low Tm target by utilizing a change of the fluorescence signals between two different detection temperatures. Furthermore, it enables us to determine quantification of each target in a single channel, possibly facilitating convenient patient care for drug treatment in clinics. PMID:25501038

  10. Wave propagation analysis in nonlinear curved single-walled carbon nanotubes based on nonlocal elasticity theory

    NASA Astrophysics Data System (ADS)

    Wang, Bo; Deng, Zichen; Ouyang, Huajiang; Zhou, Jiaxi

    2015-02-01

    Theoretical predictions are presented for wave propagation in nonlinear curved single-walled carbon nanotubes (SWCNTs). Based on the nonlocal theory of elasticity, the computational model is established, combined with the effects of geometrical nonlinearity and imperfection. In order to use the wave analysis method on this topic, a linearization method is employed. Thus, the analytical expresses of the shear frequency and flexural frequency are obtained. The effects of the geometrical nonlinearity, the initial geometrical imperfection, temperature change and magnetic field on the flexural and shear wave frequencies are investigated. Numerical results indicate that the contribution of the higher-order small scale effect on the shear deformation and the rotary inertia can lead to a reduction in the frequencies compared with results reported in the published literature. The theoretical model derived in this study should be useful for characterizing the mechanical properties of carbon nanotubes and applications of nano-devices.

  11. Characterization of the magnetic interactions of multiphase magnetocaloric materials using first-order reversal curve analysis

    NASA Astrophysics Data System (ADS)

    Franco, V.; Béron, F.; Pirota, K. R.; Knobel, M.; Willard, M. A.

    2015-05-01

    In order to understand the magnetocaloric response of materials, it is important to analyze the interactions between the different phases present in them. Recent models have analyzed the influence of these interactions on the magnetocaloric response of composites, providing an estimate value of the interaction field that is consistent with experimental results. This paper analyzes to which extent magnetization first-order reversal curve (FORC) method can be used to calculate these interactions. It is shown that the different field ranges that are explored using these techniques (inside the hysteretic region for FORC; close to magnetic saturation for magnetocaloric effect) produce interaction field values that differ in order of magnitude, with FORC being sensitive to the lower values of the interaction field and magnetocaloric analysis accounting for the larger interactions.

  12. Predictive mapping of seabed cover types using angular response curves of multibeam backscatter data: Testing different feature analysis approaches

    NASA Astrophysics Data System (ADS)

    Huang, Zhi; Siwabessy, Justy; Nichol, Scott; Anderson, Tara; Brooke, Brendan

    2013-07-01

    Angular response curves of multibeam backscatter data are used to predict the distributions of seven seabed cover types in an acoustically-complex area of the continental shelf of Western Australia. Several feature analysis approaches on the angular response curves are examined. A Probability Neural Network model was chosen for the predictive mapping, which accuracy measurement is given by a statistical coefficient Kappa. The prediction results have demonstrated the value of angular response curves for seabed mapping with Kappa=0.59 and a reasonable spatial prediction based on a visual assessment. This study also demonstrates the potential of various feature analysis approaches to improve seabed mapping. The approach to derive statistical parameters from the curves achieved significant feature reduction and some gain in statistical performance (e.g., Kappa=0.62). Its prediction map also represents a notable improvement. The first derivative analysis approach achieved the best overall statistical performance (e.g., Kappa=0.84); while the approach to remove the global slope produced the best overall prediction map as well as a significant gain in statistical performance (e.g., Kappa=0.74). We therefore recommend these three feature analysis approaches, along with the original angular response curves, for future seabed classification studies.

  13. Predicting U.S. Recessions: Financial Variables As Leading Indicators

    Microsoft Academic Search

    Arturo Estrella; Frederic S. Mishkin

    1998-01-01

    This paper examines the out-of-sample performance of various financial variables as predictors of U.S. recessions. Series such as interest rates and spreads, stock prices, and monetary aggregates are evaluated individually and in comparison with other financial and nonfinancial indicators. The analysis focuses on out-of-sample performance from one to eight quarters ahead. Results show that stock prices are useful with one-

  14. High-throughput gender identification of penguin species using melting curve analysis.

    PubMed

    Tseng, Chao-Neng; Chang, Yung-Ting; Chiu, Hui-Tzu; Chou, Yii-Cheng; Huang, Hurng-Wern; Cheng, Chien-Chung; Liao, Ming-Hui; Chang, Hsueh-Wei

    2014-04-01

    Most species of penguins are sexual monomorphic and therefore it is difficult to visually identify their genders for monitoring population stability in terms of sex ratio analysis. In this study, we evaluated the suitability using melting curve analysis (MCA) for high-throughput gender identification of penguins. Preliminary test indicated that the Griffiths's P2/P8 primers were not suitable for MCA analysis. Based on sequence alignment of Chromo-Helicase-DNA binding protein (CHD)-W and CHD-Z genes from four species of penguins (Pygoscelis papua, Aptenodytes patagonicus, Spheniscus magellanicus, and Eudyptes chrysocome), we redesigned forward primers for the CHD-W/CHD-Z-common region (PGU-ZW2) and the CHD-W-specific region (PGU-W2) to be used in combination with the reverse Griffiths's P2 primer. When tested with P. papua samples, PCR using P2/PGU-ZW2 and P2/PGU-W2 primer sets generated two amplicons of 148- and 356-bp, respectively, which were easily resolved in 1.5% agarose gels. MCA analysis indicated the melting temperature (Tm) values for P2/PGU-ZW2 and P2/PGU-W2 amplicons of P. papua samples were 79.75°C-80.5°C and 81.0°C-81.5°C, respectively. Females displayed both ZW-common and W-specific Tm peaks, whereas male was positive only for ZW-common peak. Taken together, our redesigned primers coupled with MCA analysis allows precise high throughput gender identification for P. papua, and potentially for other penguin species such as A. patagonicus, S. magellanicus, and E. chrysocome as well. PMID:24555797

  15. Analysis of the deviations from the "average" curve of sediment transport vs water flow

    NASA Astrophysics Data System (ADS)

    Nones, Michael; di Silvio, Giampaolo; Bisiacco, Mauro

    2010-05-01

    Recent studies about analytical solutions of the 1-D morphodynamic model (Fasolato et al., 2009) have shown that any river reach maintains an equilibrium configuration (namely a stationary morphological situation) under the hypothesis that the boundaries of the river reach are in equilibrium as far as solid and liquid inputs are concerned. This hypothesis means that the bottom profile of the river and the grainsize composition of the bed should, in principle, remain constant in time, provided that sediments and water entering the reach are related by an equilibrium relation (transport formula). Obviously, this condition is not always satisfied, especially in the mountain rivers, as the formation mechanisms of water and sediment inputs are quite different and seasonally delayed. These initial perturbations give place to important deviations from the "average" curve of sediment transport vs water flow, namely from the curve calculated in equilibrium conditions. This study presents a general approach that can be used to explain and possibly predict these deviations. The approach is based on the deterministic analytical solution of the harmonic river (Fasolato et al., 2009), combined with a recursive model of ARMA type, with unknown parameters, which can be estimated by minimizing a suitable mean square error, in order to obtain the best ARMA model from two different points of view: its performances both in fitting the available (measured) data and in providing a prediction algorithm for the future evolutions. The recursive model for a synthetic river reach will provide the instantaneous sediment discharge as a function of the instantaneous water flow (namely equilibrium conditions) and the water flow measured at one or more previous time (non-equilibrium conditions). This model is calibrated against a relatively small dataset of measurements about an important Italian water course: the Adige River, which flows from the Alps to the Adriatic Sea south of Venice. The analysis is limited to two gauge stations: Trento (typical mountain river reach) and Boara Pisani (typical lowland river reach).

  16. Systematic review of suicide in economic recession

    PubMed Central

    Oyesanya, Mayowa; Lopez-Morinigo, Javier; Dutta, Rina

    2015-01-01

    AIM: To provide a systematic update of the evidence concerning the relationship between economic recession and suicide. METHODS: A keyword search of Ovid Medline, Embase, Embase Classic, PsycINFO and PsycARTICLES was performed to identify studies that had investigated the association between economic recession and suicide. RESULTS: Thirty-eight studies met predetermined selection criteria and 31 of them found a positive association between economic recession and increased suicide rates. Two studies reported a negative association, two articles failed to find such an association, and three studies were inconclusive. CONCLUSION: Economic recession periods appear to increase overall suicide rates, although further research is warranted in this area, particularly in low income countries.

  17. A Melting Curve Analysis–Based PCR Assay for One-Step Genotyping of ?-Thalassemia Mutations

    PubMed Central

    Xiong, Fu; Huang, Qiuying; Chen, Xiaoyun; Zhou, Yuqiu; Zhang, Xinhua; Cai, Ren; Chen, Yajun; Xie, Jiansheng; Feng, Shanwei; Wei, Xiaofeng; Xiao, Qizhi; Zhang, Tianlang; Luo, Shiqiang; Yang, Xuehuang; Hao, Ying; Qu, Yanxia; Li, Qingge; Xu, Xiangmin

    2011-01-01

    The increasing number of disease-causing mutations demands a simple, direct, and cost-effective diagnostic genotyping technique capable of detecting multiple mutations. This study validated the efficacy of a novel melting curve analysis–based genotyping assay (MeltPro HBB assay) for 24 ?-thalassemia mutations in the Chinese population. The diagnostic potential of this assay was evaluated in 1022 pretyped genomic DNA samples, including 909 clinical cases of ?-thalassemia minor or major, using a double-blind analysis in a multicenter validation study. Reproducibility of the assay was 100%, and the limit of detection was 10 pg per reaction. All 24 ?-thalassemia mutations were accurately genotyped, and ?-thalassemia genotypes were correctly determined in all 1022 samples, yielding overall sensitivity and specificity of 100%. The concordance rate was 99.4% between this assay and the reference method. It was concluded that the MeltPro HBB assay is useful for reliable genotyping of multiple ?-thalassemia mutations in clinical settings and may have potential as a versatile method for rapid genotyping of known mutations because of its high throughput, accuracy, ease of use, and low cost. PMID:21704277

  18. A uniform analysis of HD 209458b Spitzer/IRAC light curves with Gaussian process models

    NASA Astrophysics Data System (ADS)

    Evans, Thomas M.; Aigrain, Suzanne; Gibson, Neale; Barstow, Joanna K.; Amundsen, David S.; Tremblin, Pascal; Mourier, Pierre

    2015-07-01

    We present an analysis of Spitzer/Infrared Array Camera primary transit and secondary eclipse light curves measured for HD 209458b, using Gaussian process models to marginalize over the intrapixel sensitivity variations in the 3.6 and 4.5 ?m channels and the ramp effect in the 5.8 and 8.0 ?m channels. The main advantage of this approach is that we can account for a broad range of degeneracies between the planet signal and systematics without actually having to specify a deterministic functional form for the latter. Our results do not confirm a previous claim of water absorption in transmission. Instead, our results are more consistent with a featureless transmission spectrum, possibly due to a cloud deck obscuring molecular absorption bands. For the emission data, our values are not consistent with the thermal inversion in the dayside atmosphere that was originally inferred from these data. Instead, we agree with another re-analysis of these same data, which concluded a non-inverted atmosphere provides a better fit. We find that a solar-abundance clear-atmosphere model without a thermal inversion underpredicts the measured emission in the 4.5 ?m channel, which may suggest the atmosphere is depleted in carbon monoxide. An acceptable fit to the emission data can be achieved by assuming that the planet radiates as an isothermal blackbody with a temperature of 1484 ± 18 K.

  19. Flow Curve Analysis of 17-4 PH Stainless Steel under Hot Compression Test

    NASA Astrophysics Data System (ADS)

    Mirzadeh, Hamed; Najafizadeh, Abbas; Moazeny, Mohammad

    2009-12-01

    The hot compression behavior of a 17-4 PH stainless steel (AISI 630) has been investigated at temperatures of 950 °C to 1150 °C and strain rates of 10-3 to 10 s-1. Glass powder in the Rastegaev reservoirs of the specimen was used as a lubricant material. A step-by-step procedure for data analysis in the hot compression test was given. The work hardening rate analysis was performed to reveal if dynamic recrystallization (DRX) occurred. Many samples exhibited typical DRX stress-strain curves with a single peak stress followed by a gradual fall toward the steady-state stress. At low Zener-Hollomon ( Z) parameter, this material showed a new DRX flow behavior, which was called multiple transient steady state (MTSS). At high Z, as a result of adiabatic deformation heating, a drop in flow stress was observed. The general constitutive equations were used to determine the hot working constants of this material. Moreover, after a critical discussion, the deformation activation energy of 17-4 PH stainless steel was determined as 337 kJ/mol.

  20. Biological analysis of Jeffrey nanofluid in a curved channel with heat dissipation.

    PubMed

    Maraj, E N; Akbar, Noreen Sher; Nadeem, S

    2014-12-01

    This study examines the peristaltic flow of Jeffrey nanofluid in a curved channel. The governing equations of Jeffrey nanofluid model for curved channel are derived including the effects of curvature. The highly nonlinear partial differential equations are simplified by using the long wave length and low Reynolds number assumptions. The reduced nonlinear partial differential equations are solved analytically with the help of homotopy perturbation method. The expression for pressure rise is computed through numerical integration. The physical features of pertinent parameters have been discussed by plotting the graphs of pressure rise, velocity, temperature, nanoparticle volume fraction and stream functions. It is observed that the curve-ness of the channel decreases the pressure rise in the peristaltic pumping region. Moreover, curve-ness of the channel effects the fluid flow by decreasing the fluid velocity near inner wall and increasing the velocity near the outer wall of the channel. PMID:25122841

  1. Aspects of alluvial river bank recession: some examples from the Niger delta

    Microsoft Academic Search

    T. K. S. Abam

    1997-01-01

    The recession of alluvial channel banks occurs as a sequence of mass movements or by gradual dissolution of bank materials.\\u000a Criteria for recognizing and interpreting bank recessions due to mass movement and\\/or erosion are presented. Using back analysis\\u000a technique, slope development processes are reconstructed as a sequence of bank failure episodes and erosional events. Various\\u000a mechanisms of mass bank failure

  2. Integrated analysis on static/dynamic aeroelasticity of curved panels based on a modified local piston theory

    NASA Astrophysics Data System (ADS)

    Yang, Zhichun; Zhou, Jian; Gu, Yingsong

    2014-10-01

    A flow field modified local piston theory, which is applied to the integrated analysis on static/dynamic aeroelastic behaviors of curved panels, is proposed in this paper. The local flow field parameters used in the modification are obtained by CFD technique which has the advantage to simulate the steady flow field accurately. This flow field modified local piston theory for aerodynamic loading is applied to the analysis of static aeroelastic deformation and flutter stabilities of curved panels in hypersonic flow. In addition, comparisons are made between results obtained by using the present method and curvature modified method. It shows that when the curvature of the curved panel is relatively small, the static aeroelastic deformations and flutter stability boundaries obtained by these two methods have little difference, while for curved panels with larger curvatures, the static aeroelastic deformation obtained by the present method is larger and the flutter stability boundary is smaller compared with those obtained by the curvature modified method, and the discrepancy increases with the increasing of curvature of panels. Therefore, the existing curvature modified method is non-conservative compared to the proposed flow field modified method based on the consideration of hypersonic flight vehicle safety, and the proposed flow field modified local piston theory for curved panels enlarges the application range of piston theory.

  3. Estimation of aquifer parameters from the recession of spring hydrographs - Influence of flow geometry

    NASA Astrophysics Data System (ADS)

    Birk, S.; Hergarten, S.

    2012-04-01

    The recession of spring hydrographs can be used to infer information about hydraulic aquifer properties, such as hydraulic conductivity and storage coefficient, at the catchment scale . Frequently, the approach by Rorabaugh (IAHS Publ. 63, 432-441, 1964) is employed for this purpose. Since this approach was derived for parallel flow from the aquifer to a stream, Sahuquillo and Gomez-Hernandez (Water Resour. Res. 39(6), 2003) questioned its applicability to springs with radial flow geometry. The objective of this work is to assess the influence of the flow geometry on the parameter estimates resulting from the evaluation of recession hydrographs. To this end, the radial flow equation is solved using a finite-difference model and the resulting recession curves are compared to the analytical solution by Rorabaugh. We found that the hydrograph of a homogeneous spring catchment with radial flow approaches the long-term exponential recession much more rapidly than that with parallel flow. But even more important, the recession coefficient itself strongly depends on the flow geometry: In case of radial flow the recession is significantly slower and thus the recession coefficient is lower than that predicted by the parallel flow model. As a consequence, the application of the parallel flow model to observed recession curves results in an underestimation of the hydraulic conductivity (given a constant storage) by an order of magnitude if flow to the spring is actually radial. However, the assumption of a homogeneous radial flow domain may be inappropriate at least in the case of karst catchments where the spring is fed by highly conductive karst conduits: Results from karst evolution models (e.g. Liedl et al., Water Resour. Res. 39(3), 2003) suggest that the hydraulic conductivity of the conduit system increases towards the spring. An increase inversely proportional to the distance from the spring compensates the effect of the decrease in flow cross-section towards the spring. In this case, the recession coefficient is similar to that of a homogeneous model with parallel flow geometry. Thus, the parallel flow approach by Rorabaugh indeed might be suitable for obtaining rough estimates of the hydraulic conductivity of karst aquifers at catchment scale.

  4. Enhancing the Psychological Well-Being of Elderly Individuals through Tai Chi Exercise: A Latent Growth Curve Analysis.

    ERIC Educational Resources Information Center

    Li, Fuzhong; Duncan, Terry E.; Duncan, Susan C.; McAuley, Edward; Chaumeton, Nigel R.; Harmer, Peter

    2001-01-01

    Examined whether a Tai Chi exercise program enhanced the psychological well-being of 98 elderly individuals. Analyzed repeated measures data about participants using latent growth curve analysis. Results indicate the beneficial effects of participation in the Tai Chi program. Discusses implications related to the exercise-psychological health…

  5. The Obsessive Compulsive Scale of the Child Behavior Checklist predicts obsessive-compulsive disorder: a receiver operating characteristic curve analysis

    Microsoft Academic Search

    James J. Hudziak; Robert R. Althoff; Catherine Stanger; Beijsterveldt van C. E. M; Elliot C. Nelson; Gregory L. Hanna; Dorret I. Boomsma; Richard D. Todd

    2006-01-01

    Background: The purpose of this study was to determine a score on the Obsessive Compulsive Scale (OCS) from the Child Behavior Checklist (CBCL) to screen for obsessive compulsive disorder (OCD) in children and to rigorously test the specificity and sensitivity of a single cutpoint. Methods: A receiver operating characteristic (ROC) curve analysis was applied to data from 61 patients with

  6. Analysis of Post-Kyoto CO2 Emissions Trading Using Marginal Abatement Curves A. Denny Ellerman and Annelne Decaux

    E-print Network

    Analysis of Post-Kyoto CO2 Emissions Trading Using Marginal Abatement Curves A. Denny Ellerman the advantages of emissions trading. In this paper, the authors derive MACs from EPPA, the MIT Joint Program the benefits of emissions trading in achieving the emission reduction targets implied by the Kyoto Protocol

  7. Case studies in the use of ROC curve analysis for sensor-based estimates in human computer interaction

    Microsoft Academic Search

    James Fogarty; Ryan S. Baker; Scott E. Hudson

    2005-01-01

    Applications that use sensor-based estimates face a fundamental tradeoff between true positives and false positives when examining the reliability of these estimates, one that is inadequately described by the straightforward notion of accuracy. To address this tradeoff, this paper examines the use of Receiver Operating Characteristic (ROC) curve analysis, a method that has a long history but is under-appreciated in

  8. The Obsessive Compulsive Scale of the Child Behavior Checklist Predicts Obsessive-Compulsive Disorder: A Receiver Operating Characteristic Curve Analysis

    ERIC Educational Resources Information Center

    Hudziak, James J.; Althoff, Robert R.; Stanger, Catherine; van Beijsterveldt, C. E. M.; Nelson, Elliot C.; Hanna, Gregory L.; Boomsma, Dorret I.; Todd, Richard D.

    2006-01-01

    Background: The purpose of this study was to determine a score on the Obsessive Compulsive Scale (OCS) from the Child Behavior Checklist (CBCL) to screen for obsessive compulsive disorder (OCD) in children and to rigorously test the specificity and sensitivity of a single cutpoint. Methods: A receiver operating characteristic (ROC) curve analysis…

  9. Development of a viability standard curve for microencapsulated probiotic bacteria using confocal microscopy and image analysis software.

    PubMed

    Moore, Sarah; Kailasapathy, Kasipathy; Phillips, Michael; Jones, Mark R

    2015-07-01

    Microencapsulation is proposed to protect probiotic strains from food processing procedures and to maintain probiotic viability. Little research has described the in situ viability of microencapsulated probiotics. This study successfully developed a real-time viability standard curve for microencapsulated bacteria using confocal microscopy, fluorescent dyes and image analysis software. PMID:25887694

  10. Qualitative and quantitative analysis of complex temperature-programmed desorption data by multivariate curve resolution

    NASA Astrophysics Data System (ADS)

    Rodríguez-Reyes, Juan Carlos F.; Teplyakov, Andrew V.; Brown, Steven D.

    2010-10-01

    The substantial amount of information carried in temperature-programmed desorption (TPD) experiments is often difficult to mine due to the occurrence of competing reaction pathways that produce compounds with similar mass spectrometric features. Multivariate curve resolution (MCR) is introduced as a tool capable of overcoming this problem by mathematically detecting spectral variations and correlations between several m/z traces, which is later translated into the extraction of the cracking pattern and the desorption profile for each desorbate. Different from the elegant (though complex) methods currently available to analyze TPD data, MCR analysis is applicable even when no information regarding the specific surface reaction/desorption process or the nature of the desorbing species is available. However, when available, any information can be used as constraints that guide the outcome, increasing the accuracy of the resolution. This approach is especially valuable when the compounds desorbing are different from what would be expected based on a chemical intuition, when the cracking pattern of the model test compound is difficult or impossible to obtain (because it could be unstable or very rare), and when knowing major components desorbing from the surface could in more traditional methods actually bias the quantification of minor components. The enhanced level of understanding of thermal processes achieved through MCR analysis is demonstrated by analyzing three phenomena: i) the cryogenic desorption of vinyltrimethylsilane from silicon, an introductory system where the known multilayer and monolayer components are resolved; ii) acrolein hydrogenation on a bimetallic Pt-Ni-Pt catalyst, where a rapid identification of hydrogenated products as well as other desorbing species is achieved, and iii) the thermal reaction of Ti[N(CH 3) 2] 4 on Si(100), where the products of surface decomposition are identified and an estimation of the surface composition after the thermal reaction is afforded. Since this work constitutes, to the best of our knowledge, the first effort to introduce multivariate analysis to TPD data, the procedures, algorithms and strategies employed are described in full detail.

  11. Modeling and regression analysis of semiochemical dose-response curves of insect antennal reception and behavior

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Dose-response curves with semiochemicals are reported in many articles in insect chemical ecology regarding neurophysiology and behavioral bioassays. Most such curves are shown in figures where the x-axis has order of magnitude increases in dosages versus responses on the y-axis represented by point...

  12. International Planetary Patrol observations of Saturn's rings. II. Four color phase curves and their analysis

    Microsoft Academic Search

    L. W. Esposito; K. Lumme; W. D. Benton; L. J. Martin; H. M. Ferguson; D. T. Thompson; S. E. Jones

    1979-01-01

    New phase curves for Saturn's rings at an intermediate tilt angle B approx.17 ° are presented. Quantitative results for each of the A and B rings are reported in terms of the opposition effect, phase coefficient, and best logarithmic fit to the phase curve. In each of the four colors, there is no significant difference between the shape of the

  13. Structural analysis of a curved beam element defined in global coordinates

    Microsoft Academic Search

    L. Gimena; F. N. Gimena; P. Gonzaga

    2008-01-01

    In this article, a system of twelve differential equations expressed in the global Cartesian coordinate system to simulate the structural behavior of a general curved beam element, is presented. Different shape geometry of the curved centroid line, shearing deformations, varying cross section area, non-symmetric section and generalized loads are taken into account. The lower-triangular form of the system of equations

  14. Frequency upconversion in Pr3+-Li2O-TeO2 binary glass by decay curve analysis.

    PubMed

    Rai, Vineet Kumar; Rai, S B

    2007-11-01

    Using the decay curve analysis frequency upconversion under continuous wave NIR laser radiation ( approximately 890 nm) following the non-resonant excitation at higher energies than 1G4 level has been reported. The decay curve of the antistokes emission (3P0-->3H4) shows similar behavior as that of the stokes emission (3P0-->3H4) and does not show any rise time attributing to the excited state antistokes absorption assisted by phonon emission. The covalency, bonding parameters and nephalauxetic effect for the present system has also been determined. PMID:17327145

  15. Analysis of growth curve parameters of Gobra zebu females in Senegal.

    PubMed

    Abassa, K P

    1987-11-01

    Analysis of growth curve parameters was performed using body weight data collected from 1968 through 1980 at Dahra Research Station, Senegal. Month of birth had little or no effect on mature size and maturing rate. Females born from mid-wet through mid-dry seasons were likely to reach lighter mature weights than those born from mid-dry through mid-wet seasons. Year of birth affected both mature weight and maturing rate (P less than 0.01 and P less than 0.001 respectively). Sire had effects (P less than 0.05) on maturing rate and no effect on mature size. Genetic correlations between maturing rate and body weights at birth, weaning, 12 and 18 months were 0.45 +/- 0.51, -0.21 +/- 0.52, -0.61 +/- 0.57 and -0.76 +/- 0.51 respectively. Selection for maturing rate in Gobra females would be expected to decrease weaning and post-weaning weights. The least squares means of mature size and maturing rate were 398.83 +/- 45.81 kg and 0.187% per day respectively. Gobra zebu females were about 50 and 99% mature at about 12 and 87.6 months respectively. PMID:3424450

  16. Evaluating predictors of apple scab with receiver operating characteristic curve analysis.

    PubMed

    Turechek, William W; Wilcox, Wayne F

    2005-06-01

    ABSTRACT Apple scab (Venturia inaequalis) is a perennial threat to apple production in temperate climates throughout the world. In the eastern United States, apple scab is managed almost exclusively through the regular application of fungicides. Management of the primary phase of disease is focused on preventing infection by ascospores. Management of secondary cycles of infection is largely dependent on how well primary infections were controlled. In this study, we used receiver operating characteristic curve analysis to evaluate how well mid-season assessments of the incidence of apple scab on cluster leaves, clusters (i.e., the whorl of cluster leaves), or immature fruit can serve as predictors of apple scab on harvested fruit (harvest scab) and whether these mid-season assessments of scab could be used reliably to manage scab under various damage thresholds. Results showed that assessment of scab on immature fruit was superior at predicting harvest scab than were assessments made on clusters or cluster leaves at all damage thresholds evaluated. A management action threshold of 7% scab incidence on immature fruit was identified by Youden's index as the optimal action threshold to prevent harvest scab incidence from exceeding 5%. Action thresholds could be higher or lower than 7% when economic assumptions were factored in to the decision process. The utility of such a predictor is discussed. PMID:18943785

  17. Growth curve analysis for plasma profiles using smoothing splines. Annual progress report, June 1992--June 1993

    SciTech Connect

    Imre, K.

    1993-05-01

    We are developing a profile analysis code for the statistical estimation of the parametric dependencies of the temperature and density profiles in tokamaks. Our code uses advanced statistical techniques to determine the optimal fit, i.e. the fit which minimized the predictive error. For a forty TFTR Ohmic profile dataset, our preliminary results indicate that the profile shape depends almost exclusively on q{sub a}{prime} but that the shape dependencies are not Gaussian. We are now comparing various shape models on the TFTR data. In the first six months, we have completed the core modules of the code, including a B-spline package for variable knot locations, a data-based method to determine the optimal smoothing parameters, self-consistent estimation of the bias errors, and adaptive fitting near the plasma edge. Visualization graphics already include three dimensional surface plots, and discharge by discharge plots of the predicted curves with error bars together with the actual measurements values, and plots of the basis functions with errors.

  18. Cognitive Vulnerabilities and Depression in Young Adults: An ROC Curves Analysis

    PubMed Central

    Sergi, Maria Rita; Continisio, Massimo; Tamburello, Antonino; Innamorati, Marco; Saggino, Aristide

    2013-01-01

    Objectives and Methods. The aim of the present study was to evaluate, by means of receiver operating characteristic (ROC) curves, whether cognitive vulnerabilities (CV), as measured by three well-known instruments (the Beck Hopelessness Scale, BHS; the Life Orientation Test-Revised, LOT-R; and the Attitudes Toward Self-Revised, ATS-R), independently discriminate between subjects with different severities of depression. Participants were 467 young adults (336 females and 131 males), recruited from the general population. The subjects were also administered the Beck Depression Inventory-II (BDI-II). Results. Four first-order (BHS Optimism/Low Standard; BHS Pessimism; Generalized Self-Criticism; and LOT Optimism) and two higher-order factors (Pessimism/Negative Attitudes Toward Self, Optimism) were extracted using Principal Axis Factoring analysis. Although all first-order and second-order factors were able to discriminate individuals with different depression severities, the Pessimism factor had the best performance in discriminating individuals with moderate to severe depression from those with lower depression severity. Conclusion. In the screening of young adults at risk of depression, clinicians have to pay particular attention to the expression of pessimism about the future. PMID:24058734

  19. A historical perspective of the effect of the great recession on hospitals.

    PubMed

    Shortt, Janet

    2014-08-01

    At 18 months, the Great Recession of December 2007 to June 2009 is the longest recession since World War II. The recession led to soaring unemployment, resulting in loss of employment-based health insurance for millions of people. In addition to seeing increases in uninsured patients, hospitals experienced losses in their investment portfolios, which in turn increased bad debt, charity care, and uncompensated care nationwide. Hospital executives began to devise cost-cutting strategies to balance the rising debt, such as standardizing medical equipment, cutting staff positions, and delaying construction projects and capital expenditures as well as implementing value analysis strategies. The recession is officially over, and, although economic recovery has been slow and unemployment continues to be an issue, hospitals' net revenue started improving as of 2009 and hospital construction started increasing in 2010. Still, caution is warranted in the postrecession climate, because it is unknown what effects will be seen when the Baby Boomer generation begins using Medicare. PMID:25080418

  20. Exponential Decay Nonlinear Regression Analysis of Patient Survival Curves: Preliminary Assessment in Non-Small Cell Lung Cancer

    PubMed Central

    Stewart, David J.; Behrens, Carmen; Roth, Jack; Wistuba, Ignacio I.

    2010-01-01

    Background For processes that follow first order kinetics, exponential decay nonlinear regression analysis (EDNRA) may delineate curve characteristics and suggest processes affecting curve shape. We conducted a preliminary feasibility assessment of EDNRA of patient survival curves. Methods EDNRA was performed on Kaplan-Meier overall survival (OS) and time-to-relapse (TTR) curves for 323 patients with resected NSCLC and on OS and progression-free survival (PFS) curves from selected publications. Results and Conclusions In our resected patients, TTR curves were triphasic with a “cured” fraction of 60.7% (half-life [t1/2] >100,000 months), a rapidly-relapsing group (7.4%, t1/2=5.9 months) and a slowly-relapsing group (31.9%, t1/2=23.6 months). OS was uniphasic (t1/2=74.3 months), suggesting an impact of co-morbidities; hence, tumor molecular characteristics would more likely predict TTR than OS. Of 172 published curves analyzed, 72 (42%) were uniphasic, 92 (53%) were biphasic, 8 (5%) were triphasic. With first-line chemotherapy in advanced NSCLC, 87.5% of curves from 2-3 drug regimens were uniphasic vs only 20% of those with best supportive care or 1 drug (p<0.001). 54% of curves from 2-3 drug regimens had convex rapid-decay phases vs 0% with fewer agents (p<0.001). Curve convexities suggest that discontinuing chemotherapy after 3-6 cycles “synchronizes” patient progression and death. With postoperative adjuvant chemotherapy, the PFS rapid-decay phase accounted for a smaller proportion of the population than in controls (p=0.02) with no significant difference in rapid-decay t1/2, suggesting adjuvant chemotherapy may move a subpopulation of patients with sensitive tumors from the relapsing group to the cured group, with minimal impact on time to relapse for a larger group of patients with resistant tumors. In untreated patients, the proportion of patients in the rapid-decay phase increased (p=0.04) while rapid-decay t1/2 decreased (p=0.0004) with increasing stage, suggesting that higher stage may be associated with tumor cells that both grow more rapidly and have a higher probability of surviving metastatic processes than in early stage tumors. This preliminary assessment of EDNRA suggests that it may be worth exploring this approach further using more sophisticated, statistically rigorous nonlinear modelling approaches. Using such approaches to supplement standard survival analyses could suggest or support specific testable hypotheses. PMID:20627364

  1. Light Curves and Analysis of the Overcontact Binaries GN Boo, V608 Cas and V789 Cyg

    NASA Astrophysics Data System (ADS)

    Sanders, S. J.; Bradstreet, D. H.; Hargis, J. R.

    2005-12-01

    New precision V & Rc light curves of the eclipsing overcontact binaries GN Boo, V608 Cas and V789 Cyg have been obtained using the 41-cm telescope at the Eastern University Observatory equipped with an SBIG ST-10XME CCD. GN Boo (P = 0.3016 days, m = 10.8) has only one published light curve (Blattler & Diethelm 2001a) which is noisy and had no subsequent analysis. The system was observed on 5 nights from 3 - 14 Mar 2005, accumulating approximately 750 observations in both V and Rc. Because the previously published light curve had rather large excursions in light, it was hoped that GN Boo would display total eclipses, which in fact it does. Preliminary analysis indicates that it has a mass ratio of q = 0.33, a temperature difference of 360 K between the two components, and a fillout f = 0.21. The maxima are markedly asymmetric which was modeled with a cool spot region. V608 Cas (P = 0.3804 days, m = 12.0) was observed by Blattler & Diethelm (2001b) who published a complete but noisy light curve. Although chosen for study because its published light curve suggested possible totality in the eclipses, this did not turn out to be the case. V608 Cas was observed on 3 nights from 18 Oct - 7 Nov 2004, accumulating approximately 560 observations in both V and Rc. Preliminary light curve models indicate an overcontact system with a small temperature difference between the two stars of approximately 200 K and a fillout f = 0.25. V789 Cyg (P = 0.4483, m = 13.3) is classified in the GCVS as an RR Lyrae variable, and the system was presented as such by Ponce & Sharp (2000). However their light curve looked to us very much like a W UMa light curve folded upon itself with half the true period, and so this system was observed in V and Rc on 8 nights from 27 Jun - 21 Jul 2004. The resulting light curves confirmed the overcontact nature of the system, and the modeling is still in progress. The final results of the analyses of these systems will be presented.

  2. Recalcitrant vulnerability curves: methods of analysis and the concept of fibre bridges for enhanced cavitation resistance.

    PubMed

    Cai, Jing; Li, Shan; Zhang, Haixin; Zhang, Shuoxin; Tyree, Melvin T

    2014-01-01

    Vulnerability curves (VCs) generally can be fitted to the Weibull equation; however, a growing number of VCs appear to be recalcitrant, that is, deviate from a Weibull but seem to fit dual Weibull curves. We hypothesize that dual Weibull curves in Hippophae rhamnoides L. are due to different vessel diameter classes, inter-vessel hydraulic connections or vessels versus fibre tracheids. We used dye staining techniques, hydraulic measurements and quantitative anatomy measurements to test these hypotheses. The fibres contribute 1.3% of the total stem conductivity, which eliminates the hypothesis that fibre tracheids account for the second Weibull curve. Nevertheless, the staining pattern of vessels and fibre tracheids suggested that fibres might function as a hydraulic bridge between adjacent vessels. We also argue that fibre bridges are safer than vessel-to-vessel pits and put forward the concept as a new paradigm. Hence, we tentatively propose that the first Weibull curve may be accounted by vessels connected to each other directly by pit fields, while the second Weibull curve is associated with vessels that are connected almost exclusively by fibre bridges. Further research is needed to test the concept of fibre bridge safety in species that have recalcitrant or normal Weibull curves. PMID:23600520

  3. Interactome analysis reveals that FAM161A, deficient in recessive retinitis pigmentosa, is a component of the Golgi-centrosomal network.

    PubMed

    Di Gioia, Silvio Alessandro; Farinelli, Pietro; Letteboer, Stef J F; Arsenijevic, Yvan; Sharon, Dror; Roepman, Ronald; Rivolta, Carlo

    2015-06-15

    Defects in FAM161A, a protein of unknown function localized at the cilium of retinal photoreceptor cells, cause retinitis pigmentosa, a form of hereditary blindness. By using different fragments of this protein as baits to screen cDNA libraries of human and bovine retinas, we defined a yeast two-hybrid-based FAM161A interactome, identifying 53 bona fide partners. In addition to statistically significant enrichment in ciliary proteins, as expected, this interactome revealed a substantial bias towards proteins from the Golgi apparatus, the centrosome and the microtubule network. Validation of interaction with key partners by co-immunoprecipitation and proximity ligation assay confirmed that FAM161A is a member of the recently recognized Golgi-centrosomal interactome, a network of proteins interconnecting Golgi maintenance, intracellular transport and centrosome organization. Notable FAM161A interactors included AKAP9, FIP3, GOLGA3, KIFC3, KLC2, PDE4DIP, NIN and TRIP11. Furthermore, analysis of FAM161A localization during the cell cycle revealed that this protein followed the centrosome during all stages of mitosis, likely reflecting a specific compartmentalization related to its role at the ciliary basal body during the G0 phase. Altogether, these findings suggest that FAM161A's activities are probably not limited to ciliary tasks but also extend to more general cellular functions, highlighting possible novel mechanisms for the molecular pathology of retinal disease. PMID:25749990

  4. Increasing Children’s Physical Activity During School Recess Periods

    PubMed Central

    Ludwig, David

    2013-01-01

    Objectives. We examined whether schools’ participation in the Recess Enhancement Program (REP) in the spring of 2011 was associated with higher rates of children’s vigorous physical activity. Methods. In REP, a coach guides children through age-appropriate games aimed at increasing their physical activity. During recess at 25 New York City public elementary schools (15 REP, 10 non-REP), researchers visually scanned predetermined areas (n?=?1339 scans), recording the number of sedentary, walking, and very active children. Results. Multivariate statistical analysis found that participation in REP was a significant predictor (P?=?.027) of the rate of vigorous physical activity (percentage very active in scan area) whose least-squares means were 41% in REP schools and 27% in non-REP schools. A significantly higher rate in REP schools persisted when the coach was not in the scan area, suggesting a change in the recess culture of REP schools. Conclusions. The rate of vigorous physical activity in REP schools was 14 percentage points, or 52%, higher than the rate in non-REP schools. This low-cost intervention might be a valuable addition to the tools for combating childhood obesity and worth replicating elsewhere. PMID:23678902

  5. NEW BEST1 MUTATIONS IN AUTOSOMAL RECESSIVE BESTROPHINOPATHY

    PubMed Central

    FUNG, ADRIAN T.; YZER, SUZANNE; GOLDBERG, NAOMI; WANG, HAO; NISSEN, MICHAEL; GIOVANNINI, ALFONSO; MERRIAM, JOANNA E.; BUKANOVA, ELENA N.; CAI, CAROLYN; YANNUZZI, LAWRENCE A.; TSANG, STEPHEN H.; ALLIKMETS, RANDO

    2015-01-01

    Purpose To report the ocular phenotype in patients with autosomal recessive bestrophinopathy and carriers, and to describe novel BEST1 mutations. Methods Patients with clinically suspected and subsequently genetically proven autosomal recessive bestrophinopathy underwent full ophthalmic examination and investigation with fundus autofluorescence imaging, spectral domain optical coherence tomography, electroretinography, and electrooculography. Mutation analysis of the BEST1 gene was performed through direct Sanger sequencing. Results Five affected patients from four families were identified. Mean age was 16 years (range, 6–42 years). All affected patients presented with reduced visual acuity and bilateral, hyperautofluorescent subretinal yellowish deposits within the posterior pole. Spectral domain optical coherence tomography demonstrated submacular fluid and subretinal vitelliform material in all patients. A cystoid maculopathy was seen in all but one patient. In 1 patient, the location of the vitelliform material was seen to change over a follow-up period of 3 years despite relatively stable vision. Visual acuity and fundus changes were unresponsive to topical and systemic carbonic anhydrase inhibitors and systemic steroids. Carriers had normal ocular examinations including normal fundus autofluorescence. Three novel mutations were detected. Conclusion Three novel BEST1 mutations are described, suggesting that many deleterious variants in BEST1 resulting in haploinsufficiency are still unknown. Mutations causing autosomal recessive bestrophinopathy are mostly located outside of the exons that usually harbor vitelliform macular dystrophy–associated dominant mutations. PMID:25545482

  6. Recession and Divorce in the United States, 2008-2011

    PubMed Central

    Cohen, Philip N.

    2015-01-01

    Recession may increase divorce through a stress mechanism, or reduce divorce by exacerbating cost barriers or strengthening family bonds. After establishing an individual-level model predicting U.S. women's divorce, the paper tests period effects, and whether unemployment and foreclosures are associated with the odds of divorce using the 2008-2011 American Community Survey. Results show a downward spike in the divorce rate after 2008, almost recovering to the expected level by 2011, which suggests a negative recession effect. On the other hand, state foreclosure rates are positively associated with the odds of divorce with individual controls, although this effect is not significant when state fixed effects are introduced. State unemployment rates show no effect on odds of divorce. Future research will have to determine why national divorce odds fell during the recession while state-level economic indicators were not strongly associated with divorce. Exploratory analysis which shows unemployment decreasing divorce odds for those with college degrees, while foreclosures have the opposite effect, provides one possible avenue for such research. PMID:26023246

  7. Analysis of light curves and apsidal motion of neglected southern eclipsing binary V399 Pup

    NASA Astrophysics Data System (ADS)

    Bulut, ?.; Bulut, A.; Çiçek, C.

    2014-10-01

    In this study, the Hipparcos and ASAS light curves of the eclipsing binary V399 Pup have been analyzed using the Wilson-Devinney program. The light curve analyses have found that V399 Pup is a detached binary system with eccentric orbit. The apsidal motion parameters of the system have been obtained from the O-C curve analyses. The system has been revealed to have an orbital eccentricity of e = 0.145 ± 0.006, the apsidal motion rate has been obtained ? ? = 0.0385 ± 0.0069 deg cycle-1, and it corresponds to an apsidal motion period of U = 100.2 ± 18.0 years.

  8. Ogive Curves

    NSDL National Science Digital Library

    2008-01-01

    This page contains a discussion of ogive curves, logistic regression curves, and architecture. Nice photographs of architectural applications are included. The classic Birthday Problems is included as an example of an ogive curve.

  9. Analysis of post-Kyoto CO? emissions trading using marginal abatement curves

    E-print Network

    Ellerman, A. Denny.; Decaux, Annelène.

    Marginal abatement curves (MACs) are often used heuristically to demonstrate the advantages of emissions trading. In this paper, the authors derive MACs from EPPA, the MIT Joint Program's computable general equilibrium ...

  10. High-Throughput Genome Editing and Phenotyping Facilitated by High Resolution Melting Curve Analysis

    PubMed Central

    Thomas, Holly R.; Percival, Stefanie M.; Yoder, Bradley K.; Parant, John M.

    2014-01-01

    With the goal to generate and characterize the phenotypes of null alleles in all genes within an organism and the recent advances in custom nucleases, genome editing limitations have moved from mutation generation to mutation detection. We previously demonstrated that High Resolution Melting (HRM) analysis is a rapid and efficient means of genotyping known zebrafish mutants. Here we establish optimized conditions for HRM based detection of novel mutant alleles. Using these conditions, we demonstrate that HRM is highly efficient at mutation detection across multiple genome editing platforms (ZFNs, TALENs, and CRISPRs); we observed nuclease generated HRM positive targeting in 1 of 6 (16%) open pool derived ZFNs, 14 of 23 (60%) TALENs, and 58 of 77 (75%) CRISPR nucleases. Successful targeting, based on HRM of G0 embryos correlates well with successful germline transmission (46 of 47 nucleases); yet, surprisingly mutations in the somatic tail DNA weakly correlate with mutations in the germline F1 progeny DNA. This suggests that analysis of G0 tail DNA is a good indicator of the efficiency of the nuclease, but not necessarily a good indicator of germline alleles that will be present in the F1s. However, we demonstrate that small amplicon HRM curve profiles of F1 progeny DNA can be used to differentiate between specific mutant alleles, facilitating rare allele identification and isolation; and that HRM is a powerful technique for screening possible off-target mutations that may be generated by the nucleases. Our data suggest that micro-homology based alternative NHEJ repair is primarily utilized in the generation of CRISPR mutant alleles and allows us to predict likelihood of generating a null allele. Lastly, we demonstrate that HRM can be used to quickly distinguish genotype-phenotype correlations within F1 embryos derived from G0 intercrosses. Together these data indicate that custom nucleases, in conjunction with the ease and speed of HRM, will facilitate future high-throughput mutation generation and analysis needed to establish mutants in all genes of an organism. PMID:25503746

  11. Assessing catchment hydrological functioning using discharge recession analysis based on the Kirchner's method. A case study in the Ardèche catchment (France)

    NASA Astrophysics Data System (ADS)

    Adamovic, Marko; Braud, Isabelle; Branger, Flora; Krier, Robert

    2013-04-01

    Catchments show a high degree of heterogeneity and variability, both in space and time. In order to deal with spatial heterogeneity and process variability in more efficient and more "natural and realistic" manner, model simplifications are needed. Governing equations such as the Darcy or Richards' equation, which are inherent in many hydrological models, are suitable for local scales. However, their application at much larger scales (e.g. catchment scale) remains problematic. The linear reservoir is a well-known and common approach in many catchment-based hydrological models. However, reality shows that those linear equations might not be representative enough for describing hydrological catchment behavior. Kirchner (2009), proposed a simple approach representing catchment behavior as a non-linear reservoir model, assuming that discharge at the outlet is only a function of catchment storage. He also proposed a method to determine non-linear reservoir parameters for this simple bucket model. The objective of this study is to investigate whether this approach is applicable to the Ardèche catchment (2355 km2), located in the southern part of France. The catchment is influenced by a Mediterranean climate with seasonal heavy rainfall events during autumn. The northern and north-western part of the catchment is characterized by steep slopes and igneous and metamorphic rock formations. A further objective is to relate the estimated parameters of the first-order dynamical system to catchment characteristics, in order to be able to develop a distributed model, adapted to the catchment response variability. The challenge for the Kirchner's method is the high geological and pedological heterogeneity of the Ardèche basin. We apply the Kirchner's method to 6 sub-catchments of the Ardèche ranging from 3.9 to 200 km2 using hourly rainfall and discharge data, in order to identify the discharge sensitivity function. We use the obtained corresponding parameters in a simple bucket model similar to the one proposed by Kirchner (2009). To have more representative potential evapotranspiration data used in the model, we introduce crop coefficient seasonality to better represent the data. Performance measurements with the Nash-Sutcliffe coefficient show performances above 80 %. These results clearly indicate that timing and magnitude of simulated discharge is correctly reproduced by the model. Additionally we assess the impact of the seasonality on the model parameterization yielding similar results in the discharge analysis. Our work shows that Kirchner's method can be applied successfully in the Ardèche catchment. Eventually, we observe that geology may be highlighted as a predictor that dominates the overall hydrological response in the basin. Kirchner, J. W. (2009), Catchments as simple dynamical systems: Catchment characterization, rainfall-runoff modeling, and doing hydrology backward, Water Resour. Res., 45, W02429, doi:10.1029/2008WR006912

  12. Comparative analysis of quantitative gastric emptying indices and power-exponential modelling of gastric emptying curves

    Microsoft Academic Search

    K. Jonderko

    1989-01-01

    A comparative study was undertaken on the problems of choosing a reliable measure of gastric emptying (GE). The study was based on 218 GE measurements of a radiolabelled solid meal. Power-exponential fitting of GE curves was shown to provide an excellent mathematical approximation to experimental data-a coefficient of determination r2>or=0.90 was obtained in the case of 96.3% GE curves. A

  13. Performance analysis of CNC interpolators for time-dependent feedrates along PH curves

    Microsoft Academic Search

    Yi-feng Tsai; Rida T. Farouki; Bryan Feldman

    2001-01-01

    Virtually any desired time variation V(t) of the feedrate along a curved path can be realized by real-time CNC interpolator algorithms for the Pythagorean-hodograph (PH) curves: the only stipulation is that V(t) should admit a closed-form indefinite integral F(t). Different feedrate variations V(t) can be accommodated with minimal modifications to the core algorithm by employing a modular function call to

  14. Allowables-Based Flow Curves for Nonlinear Finite-Element Analysis

    Microsoft Academic Search

    J. D. Pratt

    2007-01-01

    A methodology for developing allowables-based stress versus strain relationships for metal alloys is presented. The approach\\u000a incorporates Federal Aviation Administration\\/Department of Defense (FAA\\/DoD) Metallic Materials Property Development and Standardization\\u000a (MMPDS) statistically derived material properties for tensile yield and ultimate strengths to derive flow curves at room or\\u000a elevated temperature with an A-, B-, or S-Basis probability. The resulting flow curves

  15. A Bayesian analysis of the effect of selection for growth rate on growth curves in rabbits

    PubMed Central

    Blasco, Agustín; Piles, Miriam; Varona, Luis

    2003-01-01

    Gompertz growth curves were fitted to the data of 137 rabbits from control (C) and selected (S) lines. The animals came from a synthetic rabbit line selected for an increased growth rate. The embryos from generations 3 and 4 were frozen and thawed to be contemporary of rabbits born in generation 10. Group C was the offspring of generations 3 and 4, and group S was the contemporary offspring of generation 10. The animals were weighed individually twice a week during the first four weeks of life, and once a week thereafter, until 20 weeks of age. Subsequently, the males were weighed weekly until 40 weeks of age. The random samples of the posterior distributions of the growth curve parameters were drawn by using Markov Chain Monte Carlo (MCMC) methods. As a consequence of selection, the selected animals were heavier than the C animals throughout the entire growth curve. Adult body weight, estimated as a parameter of the Gompertz curve, was 7% higher in the selected line. The other parameters of the Gompertz curve were scarcely affected by selection. When selected and control growth curves are represented in a metabolic scale, all differences disappear. PMID:12605849

  16. A recessive genetic model and runs of homozygosity in major depressive disorder

    PubMed Central

    Power, Robert A.; Keller, Matthew C.; Ripke, Stephan; Abdellaoui, Abdel; Wray, Naomi R.; Sullivan, Patrick F; Breen, Gerome

    2014-01-01

    Genome-wide association studies (GWASs) of major depressive disorder (MDD) have yet to identify variants that surpass the threshold for genome-wide significance. A recent study reported that runs of homozygosity (ROH) are associated with schizophrenia, reflecting a novel genetic risk factor resulting from increased parental relatedness and recessive genetic effects. Here we undertake an analysis of ROH for MDD using the 9,238 MDD cases and 9,521 controls reported in a recent mega-analysis of 9 GWAS. Since evidence for association with ROH could reflect a recessive mode of action at loci, we also conducted a genome-wide association analyses under a recessive model. The genome-wide association analysis using a recessive model found no significant associations. Our analysis of ROH suggested that there was significant heterogeneity of effect across studies in effect (p=0.001), and it was associated with genotyping platform and country of origin. The results of the ROH analysis show that differences across studies can lead to conflicting systematic genome-wide differences between cases and controls that are unaccounted for by traditional covariates. They highlight the sensitivity of the ROH method to spurious associations, and the need to carefully control for potential confounds in such analyses. We found no strong evidence for a recessive model underlying MDD. PMID:24482242

  17. Analysis of late-time light curves of Type IIb, Ib and Ic supernovae

    NASA Astrophysics Data System (ADS)

    Wheeler, J. Craig; Johnson, V.; Clocchiatti, A.

    2015-06-01

    The shape of the light-curve peak of radioactive-powered core-collapse `stripped-envelope' supernovae constrains the ejecta mass, nickel mass and kinetic energy by the brightness and diffusion time for a given opacity and observed expansion velocity. Late-time light curves give constraints on the ejecta mass and energy, given the gamma-ray opacity. Previous work has shown that the principal light-curve peaks for SN IIb with small amounts of hydrogen and for hydrogen/helium-deficient SN Ib/c are often rather similar near maximum light, suggesting similar ejecta masses and kinetic energies, but that late-time light curves show a wide dispersion, suggesting a dispersion in ejecta masses and kinetic energies. It was also shown that SN IIb and SN Ib/c can have very similar late-time light curves, but different ejecta velocities demanding significantly different ejecta masses and kinetic energies. We revisit these topics by collecting and analysing well-sampled single-band and quasi-bolometric light curves from the literature. We find that the late-time light curves of stripped-envelope core-collapse supernovae are heterogeneous. We also show that the observed properties, the photospheric velocity at peak, the rise time and the late decay time, can be used to determine the mean opacity appropriate to the peak. The opacity determined in this way is considerably smaller than common estimates. We discuss how the small effective opacity may result from recombination and asymmetries in the ejecta.

  18. Fourier Analysis of Gamma-Ray Burst Light Curves: Searching for Direct Signature of Cosmological Time Dilation

    E-print Network

    Heon-Young Chang

    2001-07-17

    We study the power density spectrum (PDS) of light curves of the observed gamma-ray bursts (GRBs) to search for a direct signature for cosmological time dilation in the PDS statistics with the GRBs whose redshifts $z$'s are known. The anticorrelation of a timescale measure and a brightness measure is indirect evidence of its effect. On the other hand, we directly demonstrate that a time dilation effect can be seen in GRB light curves. We find that timescales tend to be shorter in bursts with small redshift, as expected from cosmological time-dilation effects, and we also find that there may be non-cosmological effects constituting to this correlation. We discuss its implication on interpretations of the PDS analysis results. We put forward another caution to this kind of analysis when we statistically exercise with GRBs whose $z$ is unknown.

  19. Multiresolution curves

    Microsoft Academic Search

    Adam Finkelstein; David H. Salesin

    1994-01-01

    We describe a multiresolution curve representation, based on wavelets, that conveniently supports a variety of operations: smoothing a curve; editing the overall form of a curve while preserving its details; and approximating a curve within any given error tolerance for scan conversion. We present methods to support continuous levels of smoothing as well as direct manipulation of an arbitrary portion

  20. Frequency curves

    USGS Publications Warehouse

    Riggs, H.C.

    1968-01-01

    This manual describes graphical and mathematical procedures for preparing frequency curves from samples of hydrologic data. It also discusses the theory of frequency curves, compares advantages of graphical and mathematical fitting, suggests methods of describing graphically defined frequency curves analytically, and emphasizes the correct interpretations of a frequency curve.

  1. An analysis of calibration curve models for solid-state heat-flow calorimeters

    SciTech Connect

    Hypes, P. A. (Philip A.); Bracken, D. S. (David S.); McCabe, G. (George)

    2001-01-01

    Various calibration curve models for solid-state calorimeters are compared to determine which model best fits the calibration data. The calibration data are discussed. The criteria used to select the best model are explained. A conclusion regarding the best model for the calibration curve is presented. These results can also be used to evaluate the random and systematic error of a calorimetric measurement. A linear/quadratic model has been used for decades to fit the calibration curves for wheatstone bridge calorimeters. Excellent results have been obtained using this calibration curve model. The Multical software package uses this model for the calibration curve. The choice of this model is supported by 40 years [1] of calorimeter data. There is good empirical support for the linear/quadratic model. Calorimeter response is strongly linear. Calorimeter sensitivity is slightly lower at higher powers; the negative coefficient of the x{sup 2} term accounts for this. The solid-state calorimeter is operated using the Multical [2] software package. An investigation was undertaken to determine if the linear/quadratic model is the best model for the new sensor technology used in the solid-state calorimeter.

  2. Analysis of a New Variational Model to Restore Point-Like and Curve-Like Singularities in Imaging

    SciTech Connect

    Aubert, Gilles, E-mail: gaubert@unice.fr [Universite de Nice Sophia Antipolis, Laboratoire J.A. Dieudonne (France)] [Universite de Nice Sophia Antipolis, Laboratoire J.A. Dieudonne (France); Blanc-Feraud, Laure, E-mail: Laure.Blanc-Feraud@inria.fr; Graziani, Daniele, E-mail: Daniele.Graziani@inria.fr [Inria, Morpheme CNRS/INRIA/UNSA Sophia Antipolis (France)] [Inria, Morpheme CNRS/INRIA/UNSA Sophia Antipolis (France)

    2013-02-15

    The paper is concerned with the analysis of a new variational model to restore point-like and curve-like singularities in biological images. To this aim we investigate the variational properties of a suitable energy which governs these pathologies. Finally in order to realize numerical experiments we minimize, in the discrete setting, a regularized version of this functional by fast descent gradient scheme.

  3. NEW REACTOR DESIGN AND ANALYSIS OF NON LINEAR VIBRATIONS OF DOUBLY CURVED SHALLOW SHELL UNDER A THERMAL GRADIENT

    SciTech Connect

    Chanda, S.

    2004-10-06

    The present study concerns with the effects of material orthotropy,curvature, shear ratio and circumferential modulus under the influence of a temperature distribution throughout the shell structure. Here analysis is restricted to the study of nonlinear vibration of a doubly curved shell structure considering the periodic response of a simple bending mode due to curtailment of pages. Solutions of the problems with suitable illustrations are also presented.

  4. Determination of sulphate in water and biodiesel samples by a sequential injection analysis—Multivariate curve resolution method

    Microsoft Academic Search

    Vanessa del Río; M. Soledad Larrechi; M. Pilar Callao

    2010-01-01

    A spectrophotometric sequential injection analysis (SIA-DAD) method linked to multivariate curve resolution-alternating least squares (MCR-ALS) has been developed for sulphate determination. This method involves the reaction, inside the tubes of the SIA system, of sulphate with barium-dimethylsulphonazo (III) complex, Ba-DMSA (III), displacing Ba2+ from the complex and forming DMSA (III). When the reaction products reach the detector a data matrix

  5. The Global Picture. Recession to Recovery

    ERIC Educational Resources Information Center

    Universities UK, 2010

    2010-01-01

    The objectives of this study were to: (1) document government and HE (higher education) sector responses to the recession within a select number of key countries which compete with the UK; and (2) compare these responses and analyse them by theme to draw out any common patterns. The focus of the work was to find, where possible, an evidence base…

  6. Recession curbs gas pipeline construction costs

    SciTech Connect

    Morgan, J.M.

    1983-01-24

    This paper shows how after 5 yrs. of inflation, gas pipeline construction costs have finally felt the effects of a severe building recession. First quarter (1982) construction activity, compressor equipment and drive units, and high-pressure gas-station piping are discussed. Graphs of OGJ-Morgan composite gas pipeline cost, and gas pipeline cost component indexes are presented.

  7. Gender Differences during Recess in Elementary Schools.

    ERIC Educational Resources Information Center

    Twarek, Linda S.; George, Halley S.

    A study examined the differences in what boys and girls choose, or are free to choose, to do on the playground during recess. Given the apparent problem that boys dominate the playground area, leaving girls on the perimeter, it was hypothesized that girls engage in passive, non-competitive, small group activities, whereas boys engage in…

  8. Welfare Caseloads and the 2001 Recession

    Microsoft Academic Search

    Andrew Goodman-Bacon

    2005-01-01

    This paper investigates the effects of welfare reform policies on the number of families receiving welfare (caseloads) since the 2001 recession. 1996's welfare reform legislation was passed amidst the longest economic expansion in US history, making it hard for researchers to estimate the role of policy. Furthermore, caseload research has not sufficiently explored the effects of specific policy choices within

  9. Welfare Caseloads and the 2001 Recession

    Microsoft Academic Search

    Andrew Goodman-Bacon

    2005-01-01

    This paper investigates the effects of welfare reform policies on the number of families receiving welfare (caseloads) since the 2001 recession. 1996’s welfare reform legislation was passed amidst the longest economic expansion in US history, making it hard for researchers to estimate the role of policy. Furthermore, caseload research has not sufficiently explored the effects of specific policy choices within

  10. Autosomal recessive polymicrogyria with infantile spasms and limb deformities.

    PubMed

    Ciardo, F; Zamponi, N; Specchio, N; Parmeggiani, L; Guerrini, R

    2001-12-01

    We describe two siblings, a girl and a boy, aged 4 and 2 years and 10 months respectively, born from non-consanguineous parents,with diffuse polymicrogyria, lower limb deformities, infantile spasms and developmental delay. Spasms had a good outcome under antiepileptic drug treatment. Clinical and imaging features were of identical severity in both siblings. Muscle biopsy,creatine kinase, metabolic investigations and chromosomal analysis were normal. This combination of anatomo-clinical features and their occurrence in siblings of both sexes suggests an autosomal recessive malformation syndrome. PMID:11870589

  11. Evaluating energy and non-energy impacts of energy conservation programs: A supply curve framework of analysis

    SciTech Connect

    Vine, E.; Harris, J.

    1989-06-01

    Historically, the evaluation of energy conservation programs has focused primarily on energy savings and costs. The recent, increased interest in global environmental problems (e.g., acid rain, ozone depletion, and the greenhouse effect), has made decision makers, as well as program evaluators, sensitive to the environmental impacts of all programs, including energy conservation programs. Economic impacts of programs remain important policy concerns. Many state and local jurisdictions are concerned with the net effects of energy policies on economic growth, jobs, and tax revenues, as well as the impacts of growth and development on local energy issues (e.g., construction of new power plants). Consequently, policy makers need a methodology to compare easily the energy and non-energy impacts of a specific program in a consistent way, for both retrospective analysis and for prospective planning. We present the general concepts of a proposed new approach to multi-attribute analysis, as an extension of the concept of ''supply curves of conserved energy.'' In their simplest form, energy conservation supply curves rank and display the savings from conservation measures in order of their cost-effectiveness. This simple concept is extended to reflect multiple decision criteria and some important linkages between energy and non-energy policy decisions (e.g., a ''supply curve of reduced carbon emissions, ''or a ''supply curve of net local job-creation''). The framework is flexible enough, so that policy makers can weigh and compare each of the impacts to reflect their concerns, and see the results in terms of program rankings. The advantages of this analysis framework are that it is simple to use, flexible, and replicable. 15 refs., 6 figs.

  12. Parent Involvement and Science Achievement: A Cross-Classified Multilevel Latent Growth Curve Analysis

    ERIC Educational Resources Information Center

    Johnson, Ursula Y.; Hull, Darrell M.

    2014-01-01

    The authors examined science achievement growth at Grades 3, 5, and 8 and parent school involvement at the same time points using the Early Childhood Longitudinal Study-Kindergarten Class of 1998-1999. Data were analyzed using cross-classified multilevel latent growth curve modeling with time invariant and varying covariates. School-based…

  13. Development of Oral Reading Fluency in Children with Speech or Language Impairments: A Growth Curve Analysis

    ERIC Educational Resources Information Center

    Puranik, Cynthia S.; Petscher, Yaacov; Al Otaiba, Stephanie; Catts, Hugh W.; Lonigan, Christopher J.

    2008-01-01

    This longitudinal study used piece-wise growth curve analyses to examine growth patterns in oral reading fluency for 1,991 students with speech impairments (SI) or language impairments (LI) from first through third grade. The main finding of this study was that a diagnosis of SI or LI can have a detrimental and persistent effect on early reading…

  14. The Dynamics of Self-Esteem: A Growth-Curve Analysis.

    ERIC Educational Resources Information Center

    Baldwin, Scott A.; Hoffmann, John P.

    2002-01-01

    Using 7 years of sequential data from the Family Health Study for 762 subjects aged 11 to 16 years in year 1, estimated a hierarchical growth curve model that emphasized the effects of age, life events, gender, and family cohesion on self-esteem. Results show a curvilinear relationship between age and self-esteem, suggesting that self-esteem is a…

  15. A Study of Decline Curve Analysis in the Elm Coulee Field

    E-print Network

    Harris, Seth C

    2013-08-22

    , and Niobrara. New decline curve methods have been developed to replace the standard Arps model for use in shale gas wells, but much less study has been done to verify the accuracy of these methods in shale oil wells. The examples that I investigated were Arps...

  16. The Latent Curve ARMA (P, Q) Panel Model: Longitudinal Data Analysis in Educational Research and Evaluation

    ERIC Educational Resources Information Center

    Sivo, Stephen; Fan, Xitao

    2008-01-01

    Autocorrelated residuals in longitudinal data are widely reported as common to longitudinal data. Yet few, if any, researchers modeling growth processes evaluate a priori whether their data have this feature. Sivo, Fan, and Witta (2005) found that not modeling autocorrelated residuals present in longitudinal data severely biases latent curve…

  17. Acoustic emission analysis of full-scale honeycomb sandwich composite curved fuselage panels

    Microsoft Academic Search

    Frank A. Leone Jr.; Didem Ozevin; Valery Godinez; Bao Mosinyi; John G. Bakuckas Jr.; Jonathan Awerbuch; Alan Lau; Tein-Min Tan

    2008-01-01

    Acoustic emission (AE) was monitored in notched full-scale honeycomb sandwich composite curved fuselage panels during loading. The purpose of the study was to evaluate the AE technique as a tool for detecting notch tip damage initiation and evaluating damage severity in such structures. This evaluation was a part of a more general study on the damage tolerance of six honeycomb

  18. Statistical Method for Analysis of the Disease Curve in Animals with Experimental Autoimmune Encephalomyelitis

    Microsoft Academic Search

    Yonghee Lee; Bin Zhu; Claudine Pulicicchio; Kathleen McMonagle-Strucko; Joseph G. Wettstein; Dennis Cosmatos

    2003-01-01

    Experimental autoimmune encephalomyelitis (EAE) is a procedure used in the laboratory to examine drugs that may have utility in treating multiple sclerosis (MS). The problem of modeling the disease curve in animals with EAE is studied. The classification of animals after each experiment is considered and the chi-square test is proposed to test a homogeneity between treatment groups. A mixture

  19. Type curve analysis for naturally fractured reservoirs (infinite-acting reservoir case): a new approach

    E-print Network

    Angel Restrepo, Juan Alejandro

    2000-01-01

    . The early time trend along with the late time semilog straight-line, is required in order to appropriately characterize the naturally fractured (dual porosity) system. This situation was remedied to a large degree by using log-log methods (i.e., type curves...

  20. Global heat transfer analysis in Czochralski silicon furnace with radiation on curved specular surfaces

    E-print Network

    Guo, Zhixiong "James"

    with coupled thermal radiation and heat conduction is inves- tigated in Czochralski silicon crystal growth temperature at melting point of silicon V pulling velocity Greek symbols e emissivity k thermal conductivity q radiation, and the surface of metal liquid is specular and curved. A perusal of the rel- evant literature

  1. Genetics Home Reference: Autosomal recessive cerebellar ataxia type 1

    MedlinePLUS

    ... disorder catalog Conditions > Autosomal recessive cerebellar ataxia type 1 (often shortened to ARCA1 ) On this page: Description ... What is ARCA1? Autosomal recessive cerebellar ataxia type 1 (ARCA1) is a condition characterized by progressive problems ...

  2. A breakthrough curve analysis of unstable density-driven flow and transport in homogeneous porous media

    NASA Astrophysics Data System (ADS)

    Wood, M.; Simmons, C. T.; Hutson, J. L.

    2004-03-01

    In certain hydrogeological situations, density variations occur because of changes in solute concentration, temperature, and pressure of the fluid. These include seawater intrusion, high-level radioactive waste disposal, groundwater contamination, and geothermal energy production. Under certain conditions, when the density of the invading fluid is greater than that of the ambient one, gravitational instabilities or fingers may lead to transport over larger spatial scales and significantly shorter timescales than compared with diffusion alone. This study has two key objectives: (1) to explore how the nature of a breakthrough curve changes as the density of the invading fluid changes and there is a subsequent transition from stable to unstable behavior and (2) to examine the feasibility of using 1-D advection-dispersion fitting models to fit the experimental data as the density of the invading fluid increases. Thirty-six breakthrough curve experiments were carried out in fully saturated, homogeneous sand columns. Results show that an increase in the density of the source solutions leads to breakthrough curves with lower peak concentrations at breakthrough, earlier peak breakthrough pore volume and time, and an increase in positive skewness of the breakthrough curve. Visual experiments conducted in transparent columns confirm that a transition from stable to unstable behavior occurs as the density of the injectant increases and that backward convective reflux in the high-density cases leads to dilution of the trailing edge of the pulse as evidenced by positively skewed breakthrough curves. These mixed convective systems (controlled by both forced and free convection) are characterized by a mixed convective ratio. Parameter estimation using a 1-D advection-dispersion fitting model suggests that unstable plume migration can be fitted with an apparent pore flow velocity and dispersivity at low-density gradients. However, as the density of the injectant increases, it becomes progressively difficult to estimate parameters that fit the experimental curves with a model that does not explicitly account for density effects. Significantly poorer matches are obtained when the invading solution concentration is equal to, or exceeds, the solution concentration denoted by ML (the medium- to low-density solution), i.e., invading solutions greater than approximately 13,000 mg/L in this study. Care must therefore be taken in applying standard advection-dispersion models to breakthrough curve analyses where even modest density differences are encountered.

  3. A Light Curve Analysis of Classical Novae: Free-free Emission versus Photospheric Emission

    NASA Astrophysics Data System (ADS)

    Hachisu, Izumi; Kato, Mariko

    2015-01-01

    We analyzed light curves of seven relatively slower novae, PW Vul, V705 Cas, GQ Mus, RR Pic, V5558 Sgr, HR Del, and V723 Cas, based on an optically thick wind theory of nova outbursts. For fast novae, free-free emission dominates the spectrum in optical bands rather than photospheric emission, and nova optical light curves follow the universal decline law. Faster novae blow stronger winds with larger mass-loss rates. Because the brightness of free-free emission depends directly on the wind mass-loss rate, faster novae show brighter optical maxima. In slower novae, however, we must take into account photospheric emission because of their lower wind mass-loss rates. We calculated three model light curves of free-free emission, photospheric emission, and their sum for various white dwarf (WD) masses with various chemical compositions of their envelopes and fitted reasonably with observational data of optical, near-IR (NIR), and UV bands. From light curve fittings of the seven novae, we estimated their absolute magnitudes, distances, and WD masses. In PW Vul and V705 Cas, free-free emission still dominates the spectrum in the optical and NIR bands. In the very slow novae, RR Pic, V5558 Sgr, HR Del, and V723 Cas, photospheric emission dominates the spectrum rather than free-free emission, which makes a deviation from the universal decline law. We have confirmed that the absolute brightnesses of our model light curves are consistent with the distance moduli of four classical novae with known distances (GK Per, V603 Aql, RR Pic, and DQ Her). We also discussed the reason why the very slow novae are about ~1 mag brighter than the proposed maximum magnitude versus rate of decline relation.

  4. Barcoding Melting Curve Analysis for Rapid, Sensitive, and Discriminating Authentication of Saffron (Crocus sativus L.) from Its Adulterants

    PubMed Central

    Cao, Liang; Yuan, Yuan; Chen, Min; Jin, Yan; Huang, Luqi

    2014-01-01

    Saffron (Crocus sativus L.) is one of the most important and expensive medicinal spice products in the world. Because of its high market value and premium price, saffron is often adulterated through the incorporation of other materials, such as Carthamus tinctorius L. and Calendula officinalis L. flowers, Hemerocallis L. petals, Daucus carota L. fleshy root, Curcuma longa L. rhizomes, Zea may L., and Nelumbo nucifera Gaertn. stigmas. To develop a straightforward, nonsequencing method for rapid, sensitive, and discriminating detection of these adulterants in traded saffron, we report here the application of a barcoding melting curve analysis method (Bar-MCA) that uses the universal chloroplast plant DNA barcoding region trnH-psbA to identify adulterants. When amplified at DNA concentrations and annealing temperatures optimized for the curve analysis, peaks were formed at specific locations for saffron (81.92°C) and the adulterants: D. carota (81.60°C), C. tinctorius (80.10°C), C. officinalis (79.92°C), Dendranthema morifolium (Ramat.) Tzvel. (79.62°C), N. nucifera (80.58°C), Hemerocallis fulva (L.) L. (84.78°C), and Z. mays (84.33°C). The constructed melting curves for saffron and its adulterants have significantly different peak locations or shapes. In conclusion, Bar-MCA could be a faster and more cost-effective method to authenticate saffron and detect its adulterants. PMID:25548775

  5. Large linkage analysis in 100 families with autosomal recessive spinal muscular atrophy (SMA) and 11 EPH families using 15 polymorphic loci in the region 5q11. 2-q13. 3

    Microsoft Academic Search

    B. Wirth; E. Pick; A. Leutner; A. Dadze; B. Voosen; B. Piechaczek-Wappenschmidt; S. Rudnik-Schoeneborn; J. Schoenling; K. Zerres; M. Knapp

    1994-01-01

    The autosomal recessive proximal spinal muscular atrophy (SMA) gene was mapped to the region 5q11.2-q.13.3 in 1990. Here, the authors present a large genetic linkage study of 100 SMA families and 11 CEPH families using 14 polymorphic simple sequence repeats (SSRs) and one RFLP in the region 5q11.2-q.13.3. The genetic interval between the closest SMA flanking loci D5S435 and D5S557

  6. Quantum curves

    E-print Network

    Albert Schwarz

    2014-08-16

    One says that a pair (P,Q) of ordinary differential operators specify a quantum curve if [P,Q]=const. If a pair of difference operators (K,L) obey the relation KL=const LK we say that they specify a discrete quantum curve. This terminology is prompted by well known results about commuting differential and difference operators, relating pairs of such operators with pairs of meromorphic functions on algebraic curves obeying some conditions. The goal of this paper is to study the moduli spaces of quantum curves. We will show how to quantize a pair of commuting differential or difference operators (i.e. to construct the corresponding quantum curve or discrete quantum curve). The KP-hierarchy acts on the moduli space of quantum curves; we prove that similarly the discrete KP-hierarchy acts on the moduli space of discrete quantum curves.

  7. Eigen analysis of tree-ring records: Part 1, a limited representativeness of regional curve

    NASA Astrophysics Data System (ADS)

    Yang, Bao; Sonechkin, Dmitry M.; Datsenko, Nina M.; Ivashchenko, Nadezda N.; Liu, Jingjing; Qin, Chun

    2011-12-01

    Based on a set of very long-living (2,000 years) Qilian junipers ( Sabina przewalskii Kom.) from the north-eastern part of the Tibetan Plateau (the region of Dulan), we carefully consider the regional curve standardization (RCS) technique. For this goal, we correlate deviations of individual tree-ring width records from their regional mean age-dependent curve (RC). It turns out that these correlations keep their positivity for almost all shifts between ages compared (up to 500 years and even more) evidencing each Dulan juniper to be a unique "thermometer". Just the unification of these "thermometers" in the form RC creates a spurious positive trend in the Dulan chronology. We modify the RCS technique to closer attach RC to these "thermometers" in order to construct a new chronology in which the trend is absent.

  8. Fitting sediment rating curves using regression analysis: a case study of Russian Arctic rivers

    NASA Astrophysics Data System (ADS)

    Tananaev, N. I.

    2015-03-01

    Published suspended sediment data for Arctic rivers is scarce. Suspended sediment rating curves for three medium to large rivers of the Russian Arctic were obtained using various curve-fitting techniques. Due to the biased sampling strategy, the raw datasets do not exhibit log-normal distribution, which restricts the applicability of a log-transformed linear fit. Non-linear (power) model coefficients were estimated using the Levenberg-Marquardt, Nelder-Mead and Hooke-Jeeves algorithms, all of which generally showed close agreement. A non-linear power model employing the Levenberg-Marquardt parameter evaluation algorithm was identified as an optimal statistical solution of the problem. Long-term annual suspended sediment loads estimated using the non-linear power model are, in general, consistent with previously published results.

  9. Analysis of error in using fractured gas well type curves for constant pressure production 

    E-print Network

    Schkade, David Wayne

    1987-01-01

    /xf for Case 4 r e 8 Effect of Gas Specific Gravity 9 Effect of Reservoir Temperature 10 Effect of Porosity 11 Effect of Reservoir Thickness 12 Effect of Permeability 13 Effect of Fracture Half-Length 14 Effect of Normalized Time 15 Comparison...) Constant fluid viscosity; 4) Reservoir initially at uniform pressure, p. ; 1 5) Negligible gravity forces; and 6) Small pressure gradients in the reservoir, In applying type curves to gas wells, a number of these assumptions are v io lated...

  10. Limit analysis of masonry vaults by means of curved shell finite elements and homogenization

    Microsoft Academic Search

    Enrico Milani; Gabriele Milani; Antonio Tralli

    2008-01-01

    The study of masonry vaults should take into account the essentials of the material “masonry” – i.e. heterogeneity, almost no resistance to tension combined with a good compressive strength and a high friction coefficient, as well as the overall importance of the geometry for achieving the equilibrium.In this paper, a new six-noded triangular curved element, specifically developed for the kinematic

  11. LOXL3, encoding lysyl oxidase-like 3, is mutated in a family with autosomal recessive Stickler syndrome.

    PubMed

    Alzahrani, Fatema; Al Hazzaa, Selwa A; Tayeb, Hamsa; Alkuraya, Fowzan S

    2015-04-01

    Stickler syndrome (SS) is a collagenopathy characterized by arthropathy and vitreoretinopathy with high myopia and cleft palate as common features. In a family with an autosomal recessive SS that does not map to genes known to cause autosomal recessive forms of SS, we combined autozygome and exome analysis to identify a novel missense variant in LOXL3 as the likely candidate cause. LOXL3 cross-links collagen II and its morphants phenocopy the craniofacial defects characteristic of collagen XI deficiency. We propose LOXL3 as a novel candidate gene for autosomal recessive SS. PMID:25663169

  12. Champely, S., B. Guinand, J. Thioulouse, and A. Clermidy. 1997. Functional data analysis of curve asymmetry with application to the color pattern of Hydropsyche contubernalis head capsule. Biometrics 53:294-305.

    E-print Network

    Thioulouse, Jean

    Champely, S., B. Guinand, J. Thioulouse, and A. Clermidy. 1997. Functional data analysis of curve:294-305. #12;Champely, S., B. Guinand, J. Thioulouse, and A. Clermidy. 1997. Functional data analysis of curve:294-305. #12;Champely, S., B. Guinand, J. Thioulouse, and A. Clermidy. 1997. Functional data analysis of curve

  13. Magnetic unmixing of first-order reversal curve diagrams using principal component analysis

    NASA Astrophysics Data System (ADS)

    Lascu, Ioan; Harrison, Richard; Li, Yuting; Piotrowski, Alexander; Channell, James; Muraszko, Joy; Hodell, David

    2015-04-01

    We have developed a magnetic unmixing method based on principal component analysis (PCA) of entire first-order reversal curve (FORC) diagrams. FORC diagrams are an advanced hysteresis technique that allows the quantitative characterisation of magnetic grain size, domain state, coercivity and spatial distribution of ensembles of particles within a sample. PCA has been previously applied on extracted central ridges from FORC diagrams of sediment samples containing single domain (SD) magnetite produced by magnetotactic bacteria (Heslop et al., 2014). We extend this methodology to the entire FORC space, which incorporates additional SD signatures, pseudo-single domain (PSD) and multi domain (MD) magnetite signatures, as well as fingerprints of other minerals, such as hematite (HEM). We apply the PCA by resampling the FORC distribution on a regular grid designed to encompass all significant features. Typically 80-90% of the variability within the FORC dataset is described by one or two principal components. Individual FORCs are recast as linear combinations of physically distinct end-member FORCs defined using the principal components and constraints derived from physical modelling. In a first case study we quantify the spatial variation of end-member components in surficial sediments along the North Atlantic Deep Water (NADW) from Iceland to Newfoundland. The samples have been physically separated into granulometric fractions, which added a further constraint in determining three end members used to model the magnetic ensemble, namely a coarse silt-sized MD component, a fine silt-sized PSD component, and a mixed clay-sized component containing both SD magnetite and hematite (SD+HEM). Sediments from core tops proximal to Iceland are dominated by the SD+HEM component, whereas those closer to Greenland and Canada are increasingly dominated by MD grains. Iceland sediments follow a PSD to SD+HEM trend with increasing grain-size fraction, whereas the Greenland and North America sediments follow a distinct PSD to MD trend. The PCA suggests that fine Icelandic sediments are being transported by NADW flow westward. The presence of the SD+HEM component in all size fractions of the Iceland sediment implies that this fine-grained component is not physically separable from the coarser detrital grains. This is consistent with hematite-coated sediment grains derived from European red sandstones being advected to Iceland. In a second case study we investigate temporal variations of end-member components in binary mixtures from North Atlantic sediment cores collected from the Rockall Basin and the Iberian Margin. Both these locations are characterised by sediments containing magnetosomes and fine detrital PSD grains. For the Rockall Basin samples PCA unmixing was compared to the central ridge extraction quantification method (Egli et al., 2010), yielding quantitatively similar results, whereby the detrital input decreases with time from the Last Glacial Maximum to the Holocene, superimposed on a relatively constant bacterial input. Recent Iberian Margin sediments offer insight into fine-scale variations of detrital PSD and interacting magnetosomes along a redox gradient.

  14. Effects of Tip Clearance and Casing Recess on Heat Transfer and Stage Efficiency in Axial Turbines

    NASA Technical Reports Server (NTRS)

    Ameri, A. A.; Steinthorsson, E.; Rigby, David L.

    1998-01-01

    Calculations were performed to assess the effect of the tip leakage flow on the rate of heat transfer to blade, blade tip and casing. The effect on exit angle and efficiency was also examined. Passage geometries with and without casing recess were considered. The geometry and the flow conditions of the GE-E 3 first stage turbine, which represents a modem gas turbine blade were used for the analysis. Clearance heights of 0%, 1%, 1.5% and 3% of the passage height were considered. For the two largest clearance heights considered, different recess depths were studied. There was an increase in the thermal load on all the heat transfer surfaces considered due to enlargement of the clearance gap. Introduction of recessed casing resulted in a drop in the rate of heat transfer on the pressure side but the picture on the suction side was found to be more complex for the smaller tip clearance height considered. For the larger tip clearance height the effect of casing recess was an orderly reduction in the suction side heat transfer as the casing recess height was increased. There was a marked reduction of heat load and peak values on the blade tip upon introduction of casing recess, however only a small reduction was observed on the casing itself. It was reconfirmed that there is a linear relationship between the efficiency and the tip gap height. It was also observed that the recess casing has a small effect on the efficiency but can have a moderating effect on the flow underturning at smaller tip clearances.

  15. Recession trims third-quarter building costs

    SciTech Connect

    Morgan, J.M.

    1983-05-09

    The composite cost index for building oil pipelines during the third quarter of 1982 showed a decrease of 0.96%. This decrease was due to a steady drop in the rate of inflation for most pipeline construction materials during the first 9 months of the year. The major thrust behind the pipeline materials decline was a sharp 5.3% drop in the average price of steel line pipe. However, the pipeline construction recession has failed to deter escalating pipeline labor rates.

  16. Autosomal recessive cutis laxa syndrome revisited

    PubMed Central

    Morava, Éva; Guillard, Maïlys; Lefeber, Dirk J; Wevers, Ron A

    2009-01-01

    The clinical spectrum of the autosomal recessive cutis laxa syndromes is highly heterogeneous with respect to organ involvement and severity. One of the major diagnostic criteria is to detect abnormal elastin fibers. In several other clinically similar autosomal recessive syndromes, however, the classic histological anomalies are absent, and the definite diagnosis remains uncertain. In cutis laxa patients mutations have been demonstrated in elastin or fibulin genes, but in the majority of patients the underlying genetic etiology remains unknown. Recently, we found mutations in the ATP6V0A2 gene in families with autosomal recessive cutis laxa. This genetic defect is associated with abnormal glycosylation leading to a distinct combined disorder of the biosynthesis of N- and O-linked glycans. Interestingly, similar mutations have been found in patients with wrinkly skin syndrome, without the presence of severe skin symptoms of elastin deficiency. These findings suggest that the cutis laxa and wrinkly skin syndromes are phenotypic variants of the same disorder. Interestingly many phenotypically similar patients carry no mutations in the ATP6V0A2 gene. The variable presence of protein glycosylation abnormalities in the diverse clinical forms of the wrinkled skin-cutis laxa syndrome spectrum necessitates revisiting the diagnostic criteria to be able to offer adequate prognosis assessment and counseling. This paper aims at describing the spectrum of clinical features of the various forms of autosomal recessive cutis laxa syndromes. Based on the recently unraveled novel genetic entity we also review the genetic aspects in cutis laxa syndromes including genotype–phenotype correlations and suggest a practical diagnostic approach. PMID:19401719

  17. Periosteoplasty for covering gingival recessions: Clinical results

    PubMed Central

    Virnik, Sascha; Chiari, Friedrich Michael; Gaggl, Alexander

    2009-01-01

    This is a case series in which a new technique for the surgical treatment of periodontal recessions is presented along with the results of the first clinical trial. A new technique of periodontal flap surgery was performed on 30 patients with severe periodontal recessions of the upper or lower front teeth. Root and soft tissue scaling was carried out with an open approach, then the periosteum was incised and mobilized at the apical part of the mucoperiosteum flap to cover the defect before the mucoperiosteum was reattached and fixed by sutures. Sulcus bleeding, periodontal probing depths, attachment loss and the length of the attached gingiva of the affected teeth were recorded preoperatively and at 3, 6, and 12 months postoperatively. Every clinical parameter was improved by surgery. No sulcus bleeding was observed at any time during the postoperative follow-up. A mean reattachment of 5.5 mm was noticed 12 months postoperatively at a mean probing depth of 0.3 mm. The mean height of the attached gingiva was 0 mm before surgery, 2.3 mm at three and six months postoperatively, and 2.2 mm at 12 months. The periosteum eversion technique is suitable for the treatment of gingival recessions resulting in good gingival function and a clear improvement in aesthetics. PMID:23674900

  18. Digital analysis of power systems dynamic oscillation using a curve fitting technique

    SciTech Connect

    Soliman, S.A. (Electric Power and Machines Dept., Faculty of Engineering, Ain Shams Univ., Cairo (EG)); Christensen, G.S. (Electric Engineering Dept., Univ. of Alberta, Edmonton, Alberta (CA))

    1992-01-01

    This paper discusses an application to the least error squares (LES) curve fitting technique, for analyzing the power systems dynamic oscillation, to determine the damping constant and oscillation magnitude. Unlike the other available techniques, the damping constant and oscillation magnitude can be obtained directly from the digitized samples of the swings. It is assumed that the frequency components of the power system swings are identified in the frequency spectrum. The results obtained using the proposed technique showed a good agreement with the actual values of a given example.

  19. A statistical model for the effect of casing treatment recesses on compressor rotor performance

    SciTech Connect

    Nezym, Vitaliy [National Polytechnic Institute, Mexico DF, Av. Santa Ana, 1000, CP 04430 (Mexico)

    2007-08-15

    The tip clearance between a compressor's rotating blades and its casing has an unfavorable influence on performance. By applying an abradable coating (insert) to the casing over the rotating blades, this tip clearance can be reduced to practically zero. A rather frequent variant is for the rotor blade tips to carve an entire annular recess in this coating. Rectangular recesses of various configurations have been tested in several different researches. The results of these investigations are processed using the Group Method of Data Handling. A statistical model is developed that predicts the influence of rectangular recesses on a compressor stage's efficiency and stable operating (flow) range. The model takes into account the six principal geometric parameters of a rectangular recess, as well as the Lieblein rotor diffusion factor. Analysis of the derived model has also determined which of these parameters are the most influential. Rectangular entire annular recesses are one of the simplest and most progressive types of casing treatment, and this paper concludes with an overview of existing research that supports this claim. (author)

  20. Comparative study of two surgical techniques for root coverage of large recessions in heavy smokers.

    PubMed

    Reino, Danilo M; Maia, Luciana P; Novaes, Arthur B; Souza, Sérgio L S

    2015-01-01

    Reduced root coverage due to diminished periodontal vascularity can be expected in heavy smokers. The aim of this study was to evaluate the root coverage obtained for large gingival recessions in heavy smokers using two different surgical techniques. Twenty heavy smokers were selected. Each patient had large, bilateral Miller class I or II gingival recessions (Control Group (CG): 3.30 ± 1.29; Test Group (TG): 3.45 ± 0.80) on nonmolar teeth. Clinical measurements of probing pocket depth (PPD), clinical attachment level (CAL), recession height (RH), keratinized mucosa height (KMH), and keratinized mucosa thickness (KMT) were determined at baseline and after 12 months. One side received a coronally positioned flap (CPF), while the contralateral side received the extended flap technique (EFT), both procedures carried out in conjunction with a subepithelial connective tissue graft (SCTG). Saliva samples to measure cotinine levels were taken at baseline and after 12 months as an indicator of the level of exposure to nicotine. Intergroup and intragroup analysis showed no statistical differences for the evaluated clinical parameters. Patients maintained the same exposure to smoke during the evaluation period. Both techniques resulted in low root coverage (CPF: 48.60%; EFT: 54.28%), but both techniques were effective in decreasing the gingival recessions (P ? 0.01). The variables smoke exposure, root coverage, and the thickness and height of keratinized tissue were subjected to linear regression. Regardless of the surgical technique used, heavy smoking strongly limits root coverage, especially for large recessions. PMID:26171447

  1. Maternal uniparental isodisomy causing autosomal recessive GM1 gangliosidosis: a clinical report.

    PubMed

    King, Jessica E; Dexter, Amy; Gadi, Inder; Zvereff, Val; Martin, Meaghan; Bloom, Miriam; Vanderver, Adeline; Pizzino, Amy; Schmidt, Johanna L

    2014-10-01

    Uniparental disomy is a genetic cause of disease that may result in the inheritance of an autosomal recessive condition. A child with developmental delay and hypotonia was seen and found to have severely abnormal myelination. Lysosomal enzyme testing identified an isolated deficiency of beta-galactosidase. Subsequently, homozygous missense mutations in the galactosidase, beta 1 (GLB1) gene on chromosome 3 were found. Parental testing confirmed inheritance of two copies of the same mutated maternal GLB1 gene, and no paternal copy. SNP analysis was also done to confirm paternity. The patient was ultimately diagnosed with autosomal recessive GM1 gangliosidosis caused by maternal uniparental isodisomy. We provide a review of this patient and others in which uniparental disomy (UPD) of a non-imprinted chromosome unexpectedly caused an autosomal recessive condition. This is the first case of GM1 gangliosidosis reported in the literature to have been caused by UPD. It is important for genetic counselors and other health care providers to be aware of the possibility of autosomal recessive disease caused by UPD. UPD as a cause of autosomal recessive disease drastically changes the recurrence risk for families, and discussions surrounding UPD can be complex. Working with families to understand UPD when it occurs requires a secure and trusting counselor-family relationship. PMID:24777551

  2. Skin Expression of Metalloproteinases and Tissue Inhibitor of Metalloproteinases in Sibling Patients with Recessive Dystrophic Epidermolysis and Intrafamilial Phenotypic Variation

    Microsoft Academic Search

    Christine Bodemer; Sylvie Igondjo Tchen; Sabah Ghomrasseni; Sylvie Séguier; Frédérick Gaultier; Sylvie Fraitag; Yves de Prost; Gaston Godeau

    2003-01-01

    A number of COL7A1 mutations have now been reported in recessive dystrophic epidermolysis bullosa patients, and the analysis of phenotype?genotype correlations showed evidence for interfamilial and intrafamilial phenotypic variability, occurring for the same mutation. Collagenase and stromelysin activities have been found to be overexpressed in skin cultures of some recessive dystrophic epidermolysis bullosa patients, and tissue destruction in the disease

  3. Up-to-date survival curves of children with cancer by period analysis

    Microsoft Academic Search

    H Brenner

    2003-01-01

    Survival rates of children with cancer have strongly improved during the past decades, but much of this improvement has been disclosed with substantial delay by traditional methods of survival analysis, which reflect survival experience of patients diagnosed many years ago. In this paper, the use of a new method of survival analysis, denoted period analysis, for providing more up-to-date estimates

  4. NRCS CURVE NUMBER EMPLOYED HYDROLOGIC HOMOGENEOUS REGIONALIZATION IN REGIONAL FLOOD FREQUENCY ANALYSIS

    Microsoft Academic Search

    Binaya Kumar Mishra; Kaoru Takara; Yasuto Tachikawa

    Estimation of extreme flood for different return period is required in design of various hydraulic structures. Regional flood frequency analysis is an effective method for estimating such extreme flood. Delineation of hydrologic homogeneous regions is key step in success of regional flood frequency analysis. This study deals hydrologic regionalization of Nepalese territory. Cluster analysis, a multivariate technique, is generally used

  5. Evaluation of pollutant loads from stormwater BMPs to receiving water using load frequency curves with uncertainty analysis.

    PubMed

    Park, Daeryong; Roesner, Larry A

    2012-12-15

    This study examined pollutant loads released to receiving water from a typical urban watershed in the Los Angeles (LA) Basin of California by applying a best management practice (BMP) performance model that includes uncertainty. This BMP performance model uses the k-C model and incorporates uncertainty analysis and the first-order second-moment (FOSM) method to assess the effectiveness of BMPs for removing stormwater pollutants. Uncertainties were considered for the influent event mean concentration (EMC) and the aerial removal rate constant of the k-C model. The storage treatment overflow and runoff model (STORM) was used to simulate the flow volume from watershed, the bypass flow volume and the flow volume that passes through the BMP. Detention basins and total suspended solids (TSS) were chosen as representatives of stormwater BMP and pollutant, respectively. This paper applies load frequency curves (LFCs), which replace the exceedance percentage with an exceedance frequency as an alternative to load duration curves (LDCs), to evaluate the effectiveness of BMPs. An evaluation method based on uncertainty analysis is suggested because it applies a water quality standard exceedance based on frequency and magnitude. As a result, the incorporation of uncertainty in the estimates of pollutant loads can assist stormwater managers in determining the degree of total daily maximum load (TMDL) compliance that could be expected from a given BMP in a watershed. PMID:22578429

  6. Characterization of data error in time-domain induced polarization tomography based on the analysis of decay curves

    NASA Astrophysics Data System (ADS)

    Gallistl, Jakob; Flores-Orozco, Adrián; Bücker, Matthias; Williams, Kenneth H.

    2015-04-01

    Time-domain induced polarization (TDIP) measurements are based on the recording of remnant voltages after current switch off and thus typically suffer from low signal-to-noise ratios. The analysis of the discrepancy between normal and reciprocal measurements has demonstrated to be a suitable method to quantify the data error in TDIP data sets, permitting to compute images with enhanced resolution. However, due to time constraints, it is not always possible to collect reciprocal measurements. Hence, we propose an alternative methodology to quantify data error in TDIP, which is based on fitting model curves to the measured IP decay. Based on the goodness of the fit, we can identify outliers and derive error parameters for the inversion of the tomographic TDIP data. In order to assess the practicability of our approach, we present a comparison of imaging results obtained based on the fitting of decay curves with those obtained based on the analysis of repeated measurements and normal-reciprocal measurements. Inversion results presented here were computed for extensive field data sets collected at the Rifle (CO) and Shiprock (NM) test sites. These data sets include TDIP data collected with different devices and using different IP windows.

  7. Is the Elimination of Recess in School a Violation of a Child's Basic Human Rights?

    ERIC Educational Resources Information Center

    Dubroc, Alicia M.

    2007-01-01

    The elimination of recess in schools across the country is becoming a normal occurrence in many communities, large and small. In each study presented in this content analysis, we find that free time and unstructured play is indeed essential to a child's healthy cognitive development. Article 31 of the United Nations Convention on the Rights of…

  8. Citizen Support for Northern Ohio Community College Funding Initiatives during an Economic Recession Recovery

    ERIC Educational Resources Information Center

    Flores, Patricia

    2013-01-01

    The current research, "Citizen Support for Northern Ohio Community College Funding Initiatives during an Economic Recession Recovery", asks the question: Do the citizens of Northern Ohio support community college funding during difficult economic times? Based on the theory of Stakeholder Analysis, the purpose of this concurrent,…

  9. Quantitative Vibrational Imaging by Hyperspectral Stimulated Raman Scattering Microscopy and Multivariate Curve Resolution Analysis

    PubMed Central

    Zhang, Delong; Wang, Ping; Slipchenko, Mikhail N.; Ben-Amotz, Dor; Weiner, Andrew M.; Cheng, Ji-Xin

    2013-01-01

    Spectroscopic imaging has been an increasingly critical approach for unveiling specific molecules in biological environments. Towards this goal, we demonstrate hyperspectral stimulated Raman loss (SRL) imaging by intra-pulse spectral scanning through a femtosecond pulse shaper. The hyperspectral stack of SRL images is further analyzed by a multivariate curve resolution (MCR) method to reconstruct quantitative concentration images for each individual component and retrieve the corresponding vibrational Raman spectra. Using these methods, we demonstrate quantitative mapping of dimethyl sulfoxide concentration in aqueous solutions and in fat tissue. Moreover, MCR is performed on SRL images of breast cancer cells to generate maps of principal chemical components along with their respective vibrational spectra. These results show the great capability and potential of hyperspectral SRL microscopy for quantitative imaging of complicated biomolecule mixtures through resolving overlapped Raman bands. PMID:23198914

  10. Quantifying differences in the epidemic curves from three influenza surveillance systems: a nonlinear regression analysis.

    PubMed

    Thomas, E G; McCAW, J M; Kelly, H A; Grant, K A; McVERNON, J

    2015-01-01

    Influenza surveillance enables systematic collection of data on spatially and demographically heterogeneous epidemics. Different data collection mechanisms record different aspects of the underlying epidemic with varying bias and noise. We aimed to characterize key differences in weekly incidence data from three influenza surveillance systems in Melbourne, Australia, from 2009 to 2012: laboratory-confirmed influenza notified to the Victorian Department of Health, influenza-like illness (ILI) reported through the Victorian General Practice Sentinel Surveillance scheme, and ILI cases presenting to the Melbourne Medical Deputising Service. Using nonlinear regression, we found that after adjusting for the effects of geographical region and age group, characteristics of the epidemic curve (including season length, timing of peak incidence and constant baseline activity) varied across the systems. We conclude that unmeasured factors endogenous to each surveillance system cause differences in the disease patterns recorded. Future research, particularly data synthesis studies, could benefit from accounting for these differences. PMID:24759447

  11. Modal analysis using a Fourier analyzer, curve-fitting, and modal tuning

    NASA Technical Reports Server (NTRS)

    Craig, R. R., Jr.; Chung, Y. T.

    1981-01-01

    The proposed modal test program differs from single-input methods in that preliminary data may be acquired using multiple inputs, and modal tuning procedures may be employed to define closely spaced frquency modes more accurately or to make use of frequency response functions (FRF's) which are based on several input locations. In some respects the proposed modal test proram resembles earlier sine-sweep and sine-dwell testing in that broadband FRF's are acquired using several input locations, and tuning is employed to refine the modal parameter estimates. The major tasks performed in the proposed modal test program are outlined. Data acquisition and FFT processing, curve fitting, and modal tuning phases are described and examples are given to illustrate and evaluate them.

  12. Feasibility analysis on integration of luminous environment measuring and design based on exposure curve calibration

    NASA Astrophysics Data System (ADS)

    Zou, Yuan; Shen, Tianxing

    2013-03-01

    Besides illumination calculating during architecture and luminous environment design, to provide more varieties of photometric data, the paper presents combining relation between luminous environment design and SM light environment measuring system, which contains a set of experiment devices including light information collecting and processing modules, and can offer us various types of photometric data. During the research process, we introduced a simulation method for calibration, which mainly includes rebuilding experiment scenes in 3ds Max Design, calibrating this computer aid design software in simulated environment under conditions of various typical light sources, and fitting the exposure curves of rendered images. As analytical research went on, the operation sequence and points for attention during the simulated calibration were concluded, connections between Mental Ray renderer and SM light environment measuring system were established as well. From the paper, valuable reference conception for coordination between luminous environment design and SM light environment measuring system was pointed out.

  13. Single Cell Wall Nonlinear Mechanics Revealed by a Multiscale Analysis of AFM Force-Indentation Curves.

    PubMed

    Digiuni, Simona; Berne-Dedieu, Annik; Martinez-Torres, Cristina; Szecsi, Judit; Bendahmane, Mohammed; Arneodo, Alain; Argoul, Françoise

    2015-05-01

    Individual plant cells are rather complex mechanical objects. Despite the fact that their wall mechanical strength may be weakened by comparison with their original tissue template, they nevertheless retain some generic properties of the mother tissue, namely the viscoelasticity and the shape of their walls, which are driven by their internal hydrostatic turgor pressure. This viscoelastic behavior, which affects the power-law response of these cells when indented by an atomic force cantilever with a pyramidal tip, is also very sensitive to the culture media. To our knowledge, we develop here an original analyzing method, based on a multiscale decomposition of force-indentation curves, that reveals and quantifies for the first time the nonlinearity of the mechanical response of living single plant cells upon mechanical deformation. Further comparing the nonlinear strain responses of these isolated cells in three different media, we reveal an alteration of their linear bending elastic regime in both hyper- and hypotonic conditions. PMID:25954881

  14. Type curve analysis of inertial effects in the response of a well to a slug test.

    USGS Publications Warehouse

    Kipp, K.L., Jr.

    1985-01-01

    The water level response to a slug or bailer test in a well completed in a confined aquifer, has been evaluated taking into account well-bore storage and inertial effects of the water column in the well. The response range, from overdamped with negligible inertial effects to damped oscillations, was covered employing numerical inversions of the Laplace-transform solution. By scaling the time with respect to the undamped natural period of the well-aquifer system and by using the damping parameter for a second-order damped, inertial-elastic system, a set of type curves was constructed that enables water level response data from a slug or bailer test to be analyzed under conditions where the inertial parameter is large.-from Author

  15. Acoustic emission analysis of full-scale honeycomb sandwich composite curved fuselage panels

    NASA Astrophysics Data System (ADS)

    Leone, Frank A., Jr.; Ozevin, Didem; Godinez, Valery; Mosinyi, Bao; Bakuckas, John G., Jr.; Awerbuch, Jonathan; Lau, Alan; Tan, Tein-Min

    2008-03-01

    Acoustic emission (AE) was monitored in notched full-scale honeycomb sandwich composite curved fuselage panels during loading. The purpose of the study was to evaluate the AE technique as a tool for detecting notch tip damage initiation and evaluating damage severity in such structures. This evaluation was a part of a more general study on the damage tolerance of six honeycomb sandwich composite curved panels, each containing a different damage scenario. The overall program objective was to investigate the effects of holes and notches on residual strength. The investigation was conducted using the Full-Scale Aircraft Structural Test Evaluation and Research (FASTER) facility located at the Federal Aviation Administration William J. Hughes Technical Center, Atlantic City International Airport, NJ. This paper reports on the AE results recorded during the loading to failure of two selected panels. The results show that damage initiation at the tips of the notches, and its progression along the panel, could be detected and located. These AE results were correlated with the deformation and strain fields measured through strain photogrammetry, throughout loading, at the vicinity of these notches. This correlation aided in interpreting the AE results. While the fretting among the newly created fracture surfaces generated a large number of low-intensity AE signals, the high-intensity signals generated at high load levels provided a good measure for anticipating incipient fracture. Further, the AE results located internal disbonding caused during panel fabrication. The large number of low-intensity AE signals generated from the disbonded regions was associated with the fretting among the disbonded surfaces.

  16. High resolution melting curve analysis as a new tool for rapid identification of canine parvovirus type 2 strains.

    PubMed

    Bingga, Gali; Liu, Zhicheng; Zhang, Jianfeng; Zhu, Yujun; Lin, Lifeng; Ding, Shuangyang; Guo, Pengju

    2014-01-01

    A high resolution melting (HRM) curve method was developed to identify canine parvovirus type 2 (CPV-2) strains by nested PCR. Two sets of primers, CPV-426F/426R and CPV-87R/87F, were designed that amplified a 52 bp and 53 bp product from the viral VP2 capsid gene. The region amplified by CPV-426F/426R included the A4062G and T4064A mutations in CPV-2a, CPV-2b and CPV-2c. The region amplified by CPV-87F/87R included the A3045T mutation in the vaccine strains of CPV-2 and CPV-2a, CPV-2b and CPV-2c. Faecal samples were obtained from 30 dogs that were CPV antigen-positive. The DNA was isolated from the faecal samples and PCR-amplified using the two sets of primers, and genotyped by HRM curve analysis. The PCR-HRM assay was able to distinguish single nucleotide polymorphisms between CPV-2a, CPV-2b and CPV-2c using CPV-426F/426R. CPV-2a was distinguished from CPV-2b and CPV-2c by differences in the melting temperature. CPV-2b and CPV-2c could be distinguished based on the shape of the melting curve after generating heteroduplexes using a CPV-2b reference sample. The vaccine strains of CPV-2 were identified using CPV-87F/87R. Conventional methods for genotyping CPV strains are labor intensive, expensive or time consuming; the present PCR-based HRM assay might be an attractive alternative. PMID:25159576

  17. Is AGN Variability Correlated with Other AGN Properties? ZDCF Analysis of Small Samples of Sparse Light Curves

    NASA Astrophysics Data System (ADS)

    Alexander, Tal

    The origin of AGN variability is still unknown. One approach to this problem is to look for possible correlations between the properties of the variability, such as the typical variability time-scale, and other properties of the AGN, such as luminosity or redshift. This raises the problem of quantifying the variability timescale of AGN light curves, which are often sparse and unevenly sampled. I present here a method that is particularly useful for the exploratory study of such correlations in small samples, and is based on the z-transformed discrete correlation function (ZDCF). The ZDCF is a statistical algorithm for estimating the cross-correlation function of time series. Its relative strength lies in the analysis of sparse, unevenly sampled light curves. This algorithm differs from the discrete correlation function (DCF) of Edelson \\& Krolik, from which it evolved, in that it bins the data points into equal population bins and uses Fisher's z-transform to stabilize the highly skewed distribution of the correlation coefficient. Simulations show that according to various criteria, these modifications improve the ZDCF performance over that of the DCF in the low sampling rate limit. I propose a simple measure for the variability time scale, the zero-crossing time of the ZDCF auto-correlation function. I then proceed to demonstrate the ZDCF's strength when employed together with non-parametric estimators, by using it to uncover a correlation between AGN variability time scale and luminosity properties in a small (30) simulated sample of unevenly sampled and sparse (15 observations) light curves. I show that the ZDCF is 6 times more likely than the DCF to detect the hidden correlation at the 99\\% confidence level and 3 times more likely to do so at the 90\\% confidence level.

  18. ATWS Analysis with an Advanced Boiling Curve Approach within COBRA 3CP

    Microsoft Academic Search

    A. Gensler; A. Knoll; K. Kuehnel

    2007-01-01

    In 2005 the German Reactor Safety Commission issued specific requirements on core coolability demonstration for PWR ATWS (anticipated transients without scram). Thereupon AREVA NP performed detailed analyses for all German PWRs. For a German KONVOI plant the results of an ATWS licensing analysis are presented. The plant dynamic behavior is calculated with NLOOP, while the hot channel analysis is performed

  19. The dose-response curve of the gravitropic reaction: a re-analysis.

    PubMed

    Perbal, Gérald; Jeune, Bernard; Lefranc, Agnès; Carnero-Diaz, Eugénie; Driss-Ecole, Dominique

    2002-03-01

    The dose-response curve of the gravitropic reaction is often used to evaluate the gravisensing of plant organs. It has been proposed (Larsen 1957) that the response (curvature) varies linearly as a function of the logarithm of the dose of gravistimulus. As this model fitted correctly most of the data obtained in the literature, the presentation time (tp, minimal duration of stimulation in the gravitational field to induce a response) or the presentation dose (dp, minimal quantity in g.s of stimulation to induce a response) were estimated by extrapolating down to zero curvature the straight line representing the response as a function of the logarithm of the stimulus. This method was preferred to a direct measurement of dp or tp with minute stimulations, since very slight gravitropic response cannot be distinguished from the background oscillations of the extremity of the organs. In the present review, it is shown that generally the logarithmic model (L) does not fit the experimental data published in the literature as well as the hyperbolic model (H). The H model in its simplest form is related to a response in which a ligand-receptor system is the limiting phase in the cascade of events leading to the response (Weyers et al. 1987). However, it is demonstrated that the differential growth, responsible for the curvature (and the angle of curvature), would vary as a hyperbolic function of the dose of stimulation, even if several steps involving ligand-receptor systems are responsible for the gravitropic curvature. In the H model, there is theoretically no presentation time (or presentation dose) since the curve passes through the origin. The value of the derivative of the H function equals a/b and represents the slope of the cune at the origin. It could be therefore used to estimate gravisensitivity. This provides a measurement of graviresponsiveness for threshold doses of stimulation. These results imply that the presentation time (or presentation dose) derived from the L model cannot be used anymore as an estimate of gravisensitivity. On the contrary, the perception time (minimal duration of a repeated stimulation which induces a response), which is less than 1 s, should be related to the perception of gravity. The consequences of these results on the mode of action and the nature of graviperception are discussed. PMID:12060255

  20. A rare case of respiratory disorders associated with two autosomal recessive diseases and male infertility.

    PubMed

    Mendeluk, Gabriela Ruth; Costa, Sergio López; Scigliano, Sergio; Menga, Guillermo; Demiceu, Sergio; Palaoro, Luis Alberto

    2013-01-01

    The study of nasal ciliary beat frequency (CBF) and ultrastructure may contribute to the understanding of pathognomonic cases of male infertility associated with defects in sperm motility. This study was designed to report a particular case of male infertility, characterized by the association of two respiratory autosomal recessive genetic diseases (alpha-1-antitrypsin deficiency [AAT-D] and primary ciliary dyskinesia [PCD]). A 39-year-old patient with complete sperm immotility, AAT-D, and bronchiectasis was studied in the Laboratory of Male Fertility, the Department of Urology, the Respiratory Center of a Pediatric Hospital, and in the Department of Clinical Medicine of a Rehabilitation Respiratory Hospital. Family history, physical examination, hormonal analysis, microbial assays, semen analysis, nasal ciliary function, and structure study by digital high-speed video photography and transmission electron microscopy are described. A noninvasive nasal biopsy to retrieve ciliated epithelium lining the inferior surface of the inferior nasal turbinates was performed and CBF was determined. Beat pattern was slightly curved and rigid, not wide, and metacronic in all the observed fields analyzed. CBF was 8.2 Hz in average (reference value, 10-15 Hz) Ultrastructural assay revealed absence of the inner dynein arms in 97% of the cilia observed. The final infertility accurate diagnosis was achieved by the study of nasal CBF and ultrastructure contributing to the patient health management and genetic counseling while deciding fatherhood. Beyond this particular case, the present report may open a new field of studies in male infertility, mainly in cases of asthenozoospermia. PMID:23772318

  1. A rare case of respiratory disorders associated with two autosomal recessive diseases and male infertility

    PubMed Central

    Costa, Sergio López; Scigliano, Sergio; Menga, Guillermo; Demiceu, Sergio; Palaoro, Luis Alberto

    2013-01-01

    The study of nasal ciliary beat frequency (CBF) and ultrastructure may contribute to the understanding of pathognomonic cases of male infertility associated with defects in sperm motility. This study was designed to report a particular case of male infertility, characterized by the association of two respiratory autosomal recessive genetic diseases (alpha-1-antitrypsin deficiency [AAT-D] and primary ciliary dyskinesia [PCD]). A 39-year-old patient with complete sperm immotility, AAT-D, and bronchiectasis was studied in the Laboratory of Male Fertility, the Department of Urology, the Respiratory Center of a Pediatric Hospital, and in the Department of Clinical Medicine of a Rehabilitation Respiratory Hospital. Family history, physical examination, hormonal analysis, microbial assays, semen analysis, nasal ciliary function, and structure study by digital high-speed video photography and transmission electron microscopy are described. A noninvasive nasal biopsy to retrieve ciliated epithelium lining the inferior surface of the inferior nasal turbinates was performed and CBF was determined. Beat pattern was slightly curved and rigid, not wide, and metacronic in all the observed fields analyzed. CBF was 8.2 Hz in average (reference value, 10–15 Hz) Ultrastructural assay revealed absence of the inner dynein arms in 97% of the cilia observed. The final infertility accurate diagnosis was achieved by the study of nasal CBF and ultrastructure contributing to the patient health management and genetic counseling while deciding fatherhood. Beyond this particular case, the present report may open a new field of studies in male infertility, mainly in cases of asthenozoospermia. PMID:23772318

  2. Numerical analysis of thermal creep flow in curved channels for designing a prototype of Knudsen micropump

    NASA Astrophysics Data System (ADS)

    Leontidis, V.; Brandner, J. J.; Baldas, L.; Colin, S.

    2012-05-01

    The possibility to generate a gas flow inside a channel just by imposing a tangential temperature gradient along the walls without the existence of an initial pressure difference is well known. The gas must be under rarefied conditions, meaning that the system must operate between the slip and the free molecular flow regimes, either at low pressure or/and at micro/nano-scale dimensions. This phenomenon is at the basis of the operation principle of Knudsen pumps, which are actually compressors without any moving parts. Nowadays, gas flows in the slip flow regime through microchannels can be modeled using commercial Computational Fluid Dynamics softwares, because in this regime the compressible Navier-Stokes equations with appropriate boundary conditions are still valid. A simulation procedure has been developed for the modeling of thermal creep flow using ANSYS Fluent®. The implementation of the boundary conditions is achieved by developing User Defined Functions (UDFs) by means of C++ routines. The complete first order velocity slip boundary condition, including the thermal creep effects due to the axial temperature gradient and the effect of the wall curvature, and the temperature jump boundary condition are applied. The developed simulation tool is used for the preliminary design of Knudsen micropumps consisting of a sequence of curved and straight channels.

  3. Magnetic interaction in exchange-biased bilayers: a first-order reversal curve analysis

    NASA Astrophysics Data System (ADS)

    Alonso, L.; Peixoto, T. R. F.; Cornejo, D. R.

    2010-11-01

    The distributions of coercivities and magnetic interactions in a set of polycrystalline Ni0.8Fe0.2/FeMn bilayers have been determined using the first-order reversal curve (FORC) formalism. The thickness of the permalloy (Py) film was fixed at 10 nm (nominal), while that of the FeMn film varied within the range 0-20 nm. The FORC diagrams of each bilayer displayed two clearly distinguishable regions. The main region was generated by Py particles whose coercivities were enhanced in comparison with those in which the FeMn film was absent (sample O). The minor region was produced by Py particles with coercivities similar to or slightly higher than those of particles in the Py film of sample O. Each sample presented two distributions of interaction fields, one for each region, and both were centred slightly below the exchange-bias field, thus indicating a prevalence of magnetizing interactions. These results are consistent with a grain size distribution in the Py layer and the presence of uncompensated antiferromagnetic moments.

  4. Vertically stratified two-phase flow in a curved channel: Insights from a domain perturbation analysis

    NASA Astrophysics Data System (ADS)

    Garg, P.; Picardo, J. R.; Pushpavanam, S.

    2014-07-01

    In this work, we investigate the fully developed flow field of two vertically stratified fluids (one phase flowing above the other) in a curved channel of rectangular cross section. The domain perturbation technique is applied to obtain an analytical solution in the asymptotic limit of low Reynolds numbers and small curvature ratios (the ratio of the width of the channel to its radius of curvature). The accuracy of this solution is verified by comparison with numerical simulations of the nonlinear equations. The flow is characterized by helical vortices within each fluid, which are driven by centrifugal forces. The number of vortices and their direction of circulation varies with the parameters of the system (the volume fraction, viscosity ratio, and Reynolds numbers). We identify nine distinct flow patterns and organize the parameter space into corresponding flow regimes. We show that the fully developed interface between the fluids is not horizontal, in general, but is deformed by normal stresses associated with the circulatory flow. The results are especially significant for flows in microchannels, where the Reynolds numbers are small. The mathematical results in this paper include an analytical solution to two coupled biharmonic partial differential equations; these equations arise in two-phase, two-dimensional Stokes flows.

  5. Vertically stratified two-phase flow in a curved channel: Insights from a domain perturbation analysis

    SciTech Connect

    Garg, P. [Department of Chemical Engineering, Indian Institute of Technology Roorkee, Roorkee 247 667 (India); Picardo, J. R.; Pushpavanam, S., E-mail: spush@iitm.ac.in [Department of Chemical Engineering, Indian Institute of Technology Madras, Chennai 600 036 (India)

    2014-07-15

    In this work, we investigate the fully developed flow field of two vertically stratified fluids (one phase flowing above the other) in a curved channel of rectangular cross section. The domain perturbation technique is applied to obtain an analytical solution in the asymptotic limit of low Reynolds numbers and small curvature ratios (the ratio of the width of the channel to its radius of curvature). The accuracy of this solution is verified by comparison with numerical simulations of the nonlinear equations. The flow is characterized by helical vortices within each fluid, which are driven by centrifugal forces. The number of vortices and their direction of circulation varies with the parameters of the system (the volume fraction, viscosity ratio, and Reynolds numbers). We identify nine distinct flow patterns and organize the parameter space into corresponding flow regimes. We show that the fully developed interface between the fluids is not horizontal, in general, but is deformed by normal stresses associated with the circulatory flow. The results are especially significant for flows in microchannels, where the Reynolds numbers are small. The mathematical results in this paper include an analytical solution to two coupled biharmonic partial differential equations; these equations arise in two-phase, two-dimensional Stokes flows.

  6. Bayesian analysis for nonlinear regression model under skewed errors, with application in growth curves.

    PubMed

    De la Cruz, Rolando; Branco, Márcia D

    2009-08-01

    We have considered a Bayesian approach for the nonlinear regression model by replacing the normal distribution on the error term by some skewed distributions, which account for both skewness and heavy tails or skewness alone. The type of data considered in this paper concerns repeated measurements taken in time on a set of individuals. Such multiple observations on the same individual generally produce serially correlated outcomes. Thus, additionally, our model does allow for a correlation between observations made from the same individual. We have illustrated the procedure using a data set to study the growth curves of a clinic measurement of a group of pregnant women from an obstetrics clinic in Santiago, Chile. Parameter estimation and prediction were carried out using appropriate posterior simulation schemes based in Markov Chain Monte Carlo methods. Besides the deviance information criterion (DIC) and the conditional predictive ordinate (CPO), we suggest the use of proper scoring rules based on the posterior predictive distribution for comparing models. For our data set, all these criteria chose the skew-t model as the best model for the errors. These DIC and CPO criteria are also validated, for the model proposed here, through a simulation study. As a conclusion of this study, the DIC criterion is not trustful for this kind of complex model. PMID:19629998

  7. Multivariate curve resolution for the analysis of remotely sensed thermal infrared hyperspectral images.

    SciTech Connect

    Haaland, David Michael; Stork, Christopher Lyle; Keenan, Michael Robert

    2004-07-01

    While hyperspectral imaging systems are increasingly used in remote sensing and offer enhanced scene characterization relative to univariate and multispectral technologies, it has proven difficult in practice to extract all of the useful information from these systems due to overwhelming data volume, confounding atmospheric effects, and the limited a priori knowledge regarding the scene. The need exists for the ability to perform rapid and comprehensive data exploitation of remotely sensed hyperspectral imagery. To address this need, this paper describes the application of a fast and rigorous multivariate curve resolution (MCR) algorithm to remotely sensed thermal infrared hyperspectral images. Employing minimal a priori knowledge, notably non-negativity constraints on the extracted endmember profiles and a constant abundance constraint for the atmospheric upwelling component, it is demonstrated that MCR can successfully compensate thermal infrared hyperspectral images for atmospheric upwelling and, thereby, transmittance effects. We take a semi-synthetic approach to obtaining image data containing gas plumes by adding emission gas signals onto real hyperspectral images. MCR can accurately estimate the relative spectral absorption coefficients and thermal contrast distribution of an ammonia gas plume component added near the minimum detectable quantity.

  8. Evaluation of alternative model selection criteria in the analysis of unimodal response curves using CART

    USGS Publications Warehouse

    Ribic, C.A.; Miller, T.W.

    1998-01-01

    We investigated CART performance with a unimodal response curve for one continuous response and four continuous explanatory variables, where two variables were important (ie directly related to the response) and the other two were not. We explored performance under three relationship strengths and two explanatory variable conditions: equal importance and one variable four times as important as the other. We compared CART variable selection performance using three tree-selection rules ('minimum risk', 'minimum risk complexity', 'one standard error') to stepwise polynomial ordinary least squares (OLS) under four sample size conditions. The one-standard-error and minimum-risk-complexity methods performed about as well as stepwise OLS with large sample sizes when the relationship was strong. With weaker relationships, equally important explanatory variables and larger sample sizes, the one-standard-error and minimum-risk-complexity rules performed better than stepwise OLS. With weaker relationships and explanatory variables of unequal importance, tree-structured methods did not perform as well as stepwise OLS. Comparing performance within tree-structured methods, with a strong relationship and equally important explanatory variables, the one-standard-error-rule was more likely to choose the correct model than were the other tree-selection rules 1) with weaker relationships and equally important explanatory variables; and 2) under all relationship strengths when explanatory variables were of unequal importance and sample sizes were lower.

  9. Recess and the Importance of Play. A Position Statement on Young Children and Recess.

    ERIC Educational Resources Information Center

    National Association of Early Childhood Specialists in State Departments of Education.

    In this position statement, the National Association of Early Childhood Specialists in State Departments of Education asserts that recess is an essential component of education and that preschool and elementary school children must have the opportunity to participate in regular periods of active, free play with peers. The statement summarizes…

  10. From principal curves to granular principal curves.

    PubMed

    Zhang, Hongyun; Pedrycz, Witold; Miao, Duoqian; Wei, Zhihua

    2014-06-01

    Principal curves arising as an essential construct in dimensionality reduction and data analysis have recently attracted much attention from theoretical as well as practical perspective. In many real-world situations, however, the efficiency of existing principal curves algorithms is often arguable, in particular when dealing with massive data owing to the associated high computational complexity. A certain drawback of these constructs stems from the fact that in several applications principal curves cannot fully capture some essential problem-oriented facets of the data dealing with width, aspect ratio, width change, etc. Information granulation is a powerful tool supporting processing and interpreting massive data. In this paper, invoking the underlying ideas of information granulation, we propose a granular principal curves approach, regarded as an extension of principal curves algorithms, to improve efficiency and achieve a sound accuracy-efficiency tradeoff. First, large amounts of numerical data are granulated into C intervals-information granules developed with the use of fuzzy C-means clustering and the two criteria of information granulation, which significantly reduce the amount of data to be processed at the later phase of the overall design. Granular principal curves are then constructed by determining the upper and the lower bounds of the interval data. Finally, we develop an objective function using the criteria of information confidence and specificity to evaluate the granular output formed by the principal curves. We also optimize the granular principal curves by adjusting the level of information granularity (the number of clusters), which is realized with the aid of the particle swarm optimization. A number of numeric studies completed for synthetic and real-world datasets provide a useful quantifiable insight into the effectiveness of the proposed algorithm. PMID:23996588

  11. Molecular component distribution imaging of living cells by multivariate curve resolution analysis of space-resolved Raman spectra

    NASA Astrophysics Data System (ADS)

    Ando, Masahiro; Hamaguchi, Hiro-o.

    2014-01-01

    Label-free Raman microspectroscopy combined with a multivariate curve resolution (MCR) analysis can be a powerful tool for studying a wide range of biomedical molecular systems. The MCR with the alternating least squares (MCR-ALS) technique, which retrieves the pure component spectra from complicatedly overlapped spectra, has been successfully applied to in vivo and molecular-level analysis of living cells. The principles of the MCR-ALS analysis are reviewed with a model system of titanium oxide crystal polymorphs, followed by two examples of in vivo Raman imaging studies of living yeast cells, fission yeast, and budding yeast. Due to the non-negative matrix factorization algorithm used in the MCR-ALS analysis, the spectral information derived from this technique is just ready for physical and/or chemical interpretations. The corresponding concentration profiles provide the molecular component distribution images (MCDIs) that are vitally important for elucidating life at the molecular level, as stated by Schroedinger in his famous book, "What is life?" Without any a priori knowledge about spectral profiles, time- and space-resolved Raman measurements of a dividing fission yeast cell with the MCR-ALS elucidate the dynamic changes of major cellular components (lipids, proteins, and polysaccharides) during the cell cycle. The MCR-ALS technique also resolves broadly overlapped OH stretch Raman bands of water, clearly indicating the existence of organelle-specific water structures in a living budding yeast cell.

  12. Autosomal recessive nonsyndromic deafness genes: a review

    PubMed Central

    Duman, Duygu; Tekin, Mustafa

    2013-01-01

    More than 50 percent of prelingual hearing loss is genetic in origin, and of these up to 93 percent are monogenic autosomal recessive traits. Some forms of genetic deafness can be recognized by their associated syndromic features, but in most cases, hearing loss is the only finding and is referred to as nonsyndromic deafness. To date, more than 700 different mutations have been identified in one of 42 genes in individuals with autosomal recessive nonsyndromic hearing loss (ARNSHL). Reported mutations in GJB2, encoding connexin 26, makes this gene the most common cause of hearing loss in many populations. Other relatively common deafness genes include SLC26A4, MYO15A, OTOF, TMC1, CDH23, and TMPRSS3. In this report we summarize genes and mutations reported in families with ARNSHL. Founder effects were demonstrated for some recurrent mutations but the most significant findings are the extreme locus and allelic heterogeneity and different spectrum of genes and mutations in each population. PMID:22652773

  13. VSX2 mutations in autosomal recessive microphthalmia

    PubMed Central

    Reis, Linda M.; Khan, Ayesha; Kariminejad, Ariana; Ebadi, Farhad; Tyler, Rebecca C.

    2011-01-01

    Purpose To further explore the spectrum of mutations in the Visual System Homeobox 2 (VSX2/CHX10) gene previously found to be associated with autosomal recessive microphthalmia. Methods We screened 95 probands with syndromic or isolated developmental ocular conditions (including 55 with anophthalmia/microphthalmia) for mutations in VSX2. Results Homozygous mutations in VSX2 were identified in two out of five consanguineous families with isolated microphthalmia. A novel missense mutation, c.668G>C (p.G223A), was identified in a large Pakistani family with multiple sibships affected with bilateral microphthalmia. This p.G223A mutation affects the conserved CVC motif that was shown to be important for DNA binding and repression activities of VSX2. The second mutation, c.249delG (p.Leu84SerfsX57), was identified in an Iranian family with microphthalmia; this mutation has been previously reported and is predicted to generate a severely truncated mutant protein completely lacking the VSX2 homeodomain, CVC domain and COOH-terminal regions. Conclusions Mutations in VSX2 represent an important cause of autosomal recessive microphthalmia in consanguineous pedigrees. Identification of a second missense mutation in the CVC motif emphasizes the importance of this region for normal VSX2 function. PMID:21976963

  14. Statistical signal analysis of the Phanerozoic ð13C curve: implications for Earth system evolution

    NASA Astrophysics Data System (ADS)

    Bachan, A.; Kump, L. R.; Payne, J.; Saltzman, M.; Thomas, E.

    2014-12-01

    In recent years, vast amounts of carbon isotopic data have been collected allowing the construction of the Phanerozoic ?13C curve in unprecedented detail. Our dataset comprises 8143 points spanning the last 541 m.y., with a mean spacing of 66 k.y. The average ?13C of Phanerozoic carbonate is 1 ‰ ± 2 ‰, in accordance with the canonical values measured in the past. However, the record also shows numerous, highly resolved, large (± 6 ‰) excursions whose magnitude declines through time, especially going into the late Mesozoic and Cenozoic. When the magnitude - distribution of the excursions is tabulated we find that it follows a power law: plotting the min-max differences vs. number of bins in which a particular value occurs reveals that the data fall on a semilogarithmic line with a slope of -0.23 and R2 = 0.99. The result is insensitive to outliers: smoothing the data with lowess, spline, Savitzky-Golay, and Butterworth filters yields similar results. The continuity from small variation to large perturbations, both positive and negative, suggests that, despite the numerous proposed causes for individual carbon isotopic evens, there is likely an underlying mechanism which governs the magnitude of ?13C response to perturbations. We suggest that a mechanism acting to amplify carbon cycle perturbations is the key to explaining the power-law distribution, and identify the anoxia-productivity feedback as the most likely candidate. Establishment of sulfidic conditions is accompanied by increased release of phosphate to the water column, which allows for further productivity, and thus acts as a destabilizing, positive, feedback. This feedback would act to increase carbon cycle swings irrespective of their proximal trigger. The decline in frequency of anoxic-sulfidic bottom waters in the world's oceans, and potential disappearance in the Late Mesozoic-Cenozoic, may account for a reduction in the Earth system's gain and increase in its resilience.

  15. Light Curves

    NSDL National Science Digital Library

    2013-02-12

    This is a game about light curves that will test your ability to figure out things about an asteroid from just a graph of its brightness. Astronomers use telescopes to collect light curves - measurements of the brightness of distant asteroids over time. It is part of the Killer Asteroids Web Site. The site also features a background overview of the differences between asteroids and comets, information on different types of asteroids (rubble piles vs monoliths), a discussion of how at risk Earth really is to an asteroid or comet impact, and background information on light curves.

  16. Climatic Drivers of Tropical Andean Glacier Recession, c1987 - c2006

    NASA Astrophysics Data System (ADS)

    Slayback, D. A.; Tucker, C. J.

    2011-12-01

    We report on the climatic trends associated with glacier recession in the tropical Andes from the mid-1980s to the mid-2000s. These glaciers comprise 99% of the world's tropical glaciers and occur in Bolivia, Peru, Ecuador, Colombia, and Venezuela. We previously reported on our comprehensive analysis of Landsat imagery of these glaciers, which indicated an overall recession of approximately 30% in glacierized area between c1987 and c2006, or a drop from ~2500 km2 to ~1800 km2 in total glacier area. In the current work, we have examined trends in temperature, cloud cover, and precipitation and compared these trends with those in glacier recession. For temperature and cloud cover, we use the MERRA reanalysis datasets (Modern Era Retrospective-Analysis for Research and Applications) produced by the NASA Goddard's GMAO (Global Modeling and Assimilation Office), which are based on satellite observations. For precipitation, we use the GPCP (Glocal Precipitation Climatology Project) datasets, which are based on both ground and satellite observations. We find that over the glacierized zones, the only significant trends are those in temperature, which show increases of up to 0.5 degree C per decade over some glacierized areas. Trends in cloud cover and precipitation are not generally significant. We discuss these trends in relation to glacier recession trends for each of the major glacierized areas of the tropical Andes.

  17. High-throughput real-time PCR and melt curve analysis for sexing Southern Ocean seabirds using fecal samples.

    PubMed

    Faux, Cassandra E; McInnes, Julie C; Jarman, Simon N

    2014-04-01

    Sex identification of birds is of great interest in ecological studies, however this can be very difficult in many species because their external features are almost monomorphic between the sexes. Molecular methodology has simplified this process but limitations still occur with widely accepted methods using polymerase chain reaction and gel electrophoresis, especially when applied to degraded DNA. Real-time polymerase chain reaction assays are emerging as a more efficient, sensitive, and higher throughput means of identification, but there are very few techniques validated using fecal samples and small target sizes. We present a real-time melt curve analysis assay targeting a small region of the CHD-1 gene allowing for high-throughput, sensitive, specific, and easy-to-interpret sexing results for a variety of Southern Ocean seabirds using fecal and tissue samples. PMID:24507073

  18. First-order-reversal-curve analysis of exchange-coupled SmCo/NdFeB nanocomposite alloys

    NASA Astrophysics Data System (ADS)

    Pan, Mingxiang; Zhang, Pengyue; Ge, Hongliang; Yu, Nengjun; Wu, Qiong

    2014-06-01

    Exchange-coupled SmCo5/Nd2Fe14B nanocomposite magnets have been fabricated by ball milling of the micrometer sized SmCo5 and Nd2Fe14B powders. The influence of Nd2Fe14B content on the microstructure and magnetic properties of these hybrid alloys was investigated. The alloys that show strong intergrain exchange-coupling behavior with (BH)max=2.95 MGOe was obtained when the two hard phases are well coupled. A first-order-reversal-curve (FORC) analysis was performed for both SmCo5 single-phase magnet and SmCo5/Nd2Fe14B hybrid magnet; the FORC diagrams results show two major peaks for the hybrid magnets. In both cases, the magnetization reversal behaviors for these alloys were discussed in detail and are consistent with the results of ?M plots.

  19. A Latent Growth Curve Analysis of Early and Increasing Peer Victimization as Predictors of Mental Health Across Elementary School

    PubMed Central

    Rudolph, Karen D.; Troop-Gordon, Wendy; Hessel, Elenda T.; Schmidt, Jennifer D.

    2011-01-01

    Peer victimization has been implicated as a traumatic stressor that compromises children’s long-term mental health, yet a dearth of prospective research specifically demonstrates lasting effects of early victimization. This research examined whether early (2nd grade) victimization and increasing (2nd – 5th grade) victimization independently predicted depressive symptoms and aggressive behavior (overt and relational) in 5th grade. Participants included 433 children (238 girls, 195 boys). Children reported on peer victimization and depressive symptoms; teachers reported on peer victimization and aggressive behavior. Latent growth curve analysis revealed that both early and increasing victimization made unique contributions to subsequent depressive symptoms and aggressive behavior. Relational aggression was particularly likely to follow victimization in girls. PMID:21229448

  20. A latent growth curve analysis of early and increasing peer victimization as predictors of mental health across elementary school.

    PubMed

    Rudolph, Karen D; Troop-Gordon, Wendy; Hessel, Elenda T; Schmidt, Jennifer D

    2011-01-01

    Peer victimization has been implicated as a traumatic stressor that compromises children's long-term mental health, yet a dearth of prospective research documents lasting effects of early victimization. This study examined whether early (2nd grade) and increasing (2nd-5th grade) victimization predicted 5th grade depressive symptoms and aggressive behavior. Children (238 girls, 195 boys) reported on victimization and depressive symptoms; teachers reported on victimization and aggressive behavior. Latent growth curve analysis revealed that early and increasing victimization made unique contributions to depressive symptoms and aggressive behavior. Relational aggression was particularly likely to follow victimization in girls. This study reveals that victimization contributes to mental health over an extended period and elucidates the role of early versus increasing victimization, supporting the need for programs to prevent the pernicious mental health consequences of victimization. PMID:21229448

  1. Statistical methods for pavement performance curve building, historical analysis, data sampling and storage. Final report, May 1997--July 1998

    SciTech Connect

    Zimmerman, K.A.; Bahulkar, A.M.

    1998-08-01

    The use of a pavement management system provides a state highway agency with the tools necessary to conduct a multi-year analysis of the maintenance and rehabilitation needs within the state based on both current needs and expected future conditions. In order to adequately predict future conditions, pavement performance models must be developed to reflect the deterioration trends of the agency`s pavements. At the time the SDDOT pavement management system was implemented in 1994, the Department developed a new condition rating system to evaluate the existing conditions of the state maintained pavements. At the same time, expert-based pavement performance models were developed to approximate the deterioration patterns of the highways based on pavement families (groupings of pavements with similar characteristics). A recommendation from that study (SD93-14) was to update the curves based on historical performance once sufficient data had been collected.

  2. A Global Approach to Accurate and Automatic Quantitative Analysis of NMR Spectra by Complex Least-Squares Curve Fitting

    NASA Astrophysics Data System (ADS)

    Martin, Y. L.

    The performance of quantitative analysis of 1D NMR spectra depends greatly on the choice of the NMR signal model. Complex least-squares analysis is well suited for optimizing the quantitative determination of spectra containing a limited number of signals (<30) obtained under satisfactory conditions of signal-to-noise ratio (>20). From a general point of view it is concluded, on the basis of mathematical considerations and numerical simulations, that, in the absence of truncation of the free-induction decay, complex least-squares curve fitting either in the time or in the frequency domain and linear-prediction methods are in fact nearly equivalent and give identical results. However, in the situation considered, complex least-squares analysis in the frequency domain is more flexible since it enables the quality of convergence to be appraised at every resonance position. An efficient data-processing strategy has been developed which makes use of an approximate conjugate-gradient algorithm. All spectral parameters (frequency, damping factors, amplitudes, phases, initial delay associated with intensity, and phase parameters of a baseline correction) are simultaneously managed in an integrated approach which is fully automatable. The behavior of the error as a function of the signal-to-noise ratio is theoretically estimated, and the influence of apodization is discussed. The least-squares curve fitting is theoretically proved to be the most accurate approach for quantitative analysis of 1D NMR data acquired with reasonable signal-to-noise ratio. The method enables complex spectral residuals to be sorted out. These residuals, which can be cumulated thanks to the possibility of correcting for frequency shifts and phase errors, extract systematic components, such as isotopic satellite lines, and characterize the shape and the intensity of the spectral distortion with respect to the Lorentzian model. This distortion is shown to be nearly independent of the chemical species, of the nature of the molecular site, and of the type of nucleus, but to vary significantly with the spectrometer. The potential of the method for accurate fast and fully automatic quantitative analysis is illustrated in the case of natural-abundance deuterium NMR spectra such as those of linalool and ethyl mandelate.

  3. Adolescents' physical activity at recess and actions to promote a physically active school day in four Finnish schools.

    PubMed

    Haapala, H L; Hirvensalo, M H; Laine, K; Laakso, L; Hakonen, H; Lintunen, T; Tammelin, T H

    2014-10-01

    The national Finnish Schools on the Move programme support schools with their individual plans to promote school-based physical activity (PA). We examined the changes in adolescents' recess and overall PA in four lower secondary schools and described the school actions to promote students' PA and the local contact persons' perceptions of the effects. Recess and overall PA were assessed four times by anonymous questionnaires from students in grades 7-9 (n = 789) in 2010-12, and local contact persons (n = 7) provided information on school actions with diaries, interviews and surveys. Student data were analysed with descriptive statistics and chi-square tests, and school actions data were analysed with quantitative content analysis. The proportion of students who participated in physical activities at recess at least sometimes increased from 30% to 49% in physically active play and from 33% to 42% in ball games, mostly due to improvements in males' participation. Females' participation in recess activities increased in two schools with gender-specific physical activities or facilities. Overall PA levels declined slightly. Organized recess activities, student recess activators and equipment provision and sports facilities development were considered to have affected students' PA positively. Solutions for getting females more physically active in the school setting are needed. PMID:24906635

  4. Adolescents’ physical activity at recess and actions to promote a physically active school day in four Finnish schools

    PubMed Central

    Haapala, H. L.; Hirvensalo, M. H.; Laine, K.; Laakso, L.; Hakonen, H.; Lintunen, T.; Tammelin, T. H.

    2014-01-01

    The national Finnish Schools on the Move programme support schools with their individual plans to promote school-based physical activity (PA). We examined the changes in adolescents’ recess and overall PA in four lower secondary schools and described the school actions to promote students’ PA and the local contact persons’ perceptions of the effects. Recess and overall PA were assessed four times by anonymous questionnaires from students in grades 7–9 (n = 789) in 2010–12, and local contact persons (n = 7) provided information on school actions with diaries, interviews and surveys. Student data were analysed with descriptive statistics and chi-square tests, and school actions data were analysed with quantitative content analysis. The proportion of students who participated in physical activities at recess at least sometimes increased from 30% to 49% in physically active play and from 33% to 42% in ball games, mostly due to improvements in males’ participation. Females’ participation in recess activities increased in two schools with gender-specific physical activities or facilities. Overall PA levels declined slightly. Organized recess activities, student recess activators and equipment provision and sports facilities development were considered to have affected students’ PA positively. Solutions for getting females more physically active in the school setting are needed. PMID:24906635

  5. New approaches to direct gradient analysis using environmental scalars and statistical curve-fitting procedures

    Microsoft Academic Search

    M. P. Austin; R. B. Cunningham; P. M. Fleming

    1984-01-01

    The conceptual framework of direct gradient analysis (DGA) is discussed in relation to the functional, factorial approach to vegetation. Both approaches use abstract simplified environment gradients with which to correlate vegetation response. Environmental scalars based on physical process models of environment and\\/or known biological growth processes can be incorporated to make analyses less location specific. An example of an environmental

  6. THE XMM-NEWTON /EPIC X-RAY LIGHT CURVE ANALYSIS OF WR 6

    E-print Network

    Ignace, R.

    We obtained four pointings of over 100 ks each of the well-studied Wolf-Rayet star WR 6 with the XMM-Newton satellite. With a first paper emphasizing the results of spectral analysis, this follow-up highlights the X-ray ...

  7. Analytical solutions for recession analyses of sloping aquifers in alpine catchments

    NASA Astrophysics Data System (ADS)

    Pauritsch, Marcus; Hergarten, Stefan; Winkler, Gerfried; Birk, Steffen

    2015-04-01

    Analytical solutions for the discharge recession of sloping aquifers are commonly used to simulate the runoff of shallow aquifers with slope angles of a few degrees and in particular hillslopes. However, in alpine catchments, potentially deeper aquifers represented by debris accumulations such as relict rock glaciers can be found in areas with much steeper slope angles. These aquifers might be important for flood reduction and drought prevention and the discharged water can be used for drinking water supply and small hydroelectric power plants. Here it is attempted to reproduce the recession behavior of such highly inclined aquifers by applying existing analytical solutions for sloping aquifers. More specifically, an analytical solution for the discharge recession of a sloping aquifer is compared to a numerical model (MODFLOW) for a variety of slope angles. In addition a sensitivity analysis is made to reveal the effects of the various approximations introduced in the analytical solution, such as homogeneity, parallel side boundaries and a straight profile. The results show that the deviation between the analytical solution and the numerical model depends on the hydraulic properties and is in general acceptable for all tested slope angles. However, the sensitivity analysis shows that the simplifying assumptions and especially the initial condition have great impact on the discharge recession. Therefore, only the long-term behavior of the analytical solution should be considered if the model is employed for aquifer characterization. In summary, the combined use of analytical solutions and simple numerical models helps to better understand the opportunities and limitations of the recession analysis of sloping aquifers.

  8. Bluff formation and long-term recession rates, southwestern Lake Michigan

    SciTech Connect

    Rovey, C.W. II (Southwest Missouri State Univ., Springfield, MO (United States))

    1992-01-01

    Where eroding cohesive sediments are present, Lake Michigan bluffs range up to 140 ft. in height and expose multiple stratigraphic units. According to the model presented here, bluffs form as a wave cut terrace erodes inland from a point near the original shoreline. The erosion plane is nearly horizontal, in contrast with the eastward dip of the glacial units inherited from underlying bedrock. Therefore, terraces eroding inland (west) produce progressively higher bluffs and expose successively older units at the toe and beneath the lake. This process repeated several times as lake levels sequentially dropped to their modern stage. The initial modern shoreline, and hence the width of the wave cut terrace, was determined from 4 offshore seismic profiles. It is picked as an inflection point in the slope of the lake bed, occurring offshore of dipping reflectors intersecting the lake bottom. The calculated average recession rate over the 2,500 year duration of the modern stage is 5 ft/yr in contrast to average rates of 2 ft/yr measured over the last century. Thus rates decrease through time as the terrace widens and wave energy is damped. By correlating bluff height to amount of recession of modern bluffs, a third rate of 12 ft/yr of the first 800 years of a recession is calculated for relict bluffs formed at the Nipissing II level. The 3 rates define a steeply decaying exponential curve in early stages of bluff retreat, flattening into a nearly linear function after 1,000 years.

  9. Bluff evolution and long-term recession rates, southwestern Lake Michigan

    NASA Astrophysics Data System (ADS)

    Rovey, C. W.; Borucki, M. K.

    1994-06-01

    Where eroding cohesive sediments are present, Lake Michigan bluffs range up to 40 m in height, exposing multiple glacial stratigraphic units. Following the model presented here, bluffs form as a wave-cut terrace erodes inland from a point near the original shoreline. The erosion plane is nearly horizontal, in contrast with the eastward dip of the glacial units inherited from underlying bedrock. Therefore, terraces eroding inland produce progressively higher bluffs and expose successively older units at the toe and beneath the lake. This process was repeated several times as lake levels sequentially dropped to their modern stage. The initial modern shoreline, and hence the width of the wave-cut terrace, was determined from four offshore seismic and bottom-sampling profiles. It was picked as an inflection point in the lake bed, occurring offshore of dipping reflectors intersecting the lake bottom. The calculated average recession rate over a 2500-year duration of the modern stage is 1.5 m/yr in contrast to average rates of approximately 0.6 m/yr measured over the last century. Thus rates decrease through time as the terrace widens and wave energy is dampened. By correlating bluff height to recession distance, a third rate of approximately 2.7 m/yr for the first 940 years of recession is calculated from relict Nipissing bluffs. The three rates define a steeply decaying exponential curve in early stages of bluff retreat, flattening into a nearly linear function after 1000 years.

  10. A Novel Mutation in the Transglutaminase-1 Gene in an Autosomal Recessive Congenital Ichthyosis Patient

    PubMed Central

    Vaigundan, D.; Kalmankar, Neha V.; Krishnappa, J.; Gowda, N. Yellappa; Kutty, A. V. M.; Krishnaswamy, Patnam R.

    2014-01-01

    Structure-function implication on a novel homozygous Trp250/Gly mutation of transglutaminase-1 (TGM1) observed in a patient of autosomal recessive congenital ichthyosis is invoked from a bioinformatics analysis. Structural consequences of this mutation are hypothesized in comparison to homologous enzyme human factor XIIIA accepted as valid in similar structural analysis and are projected as guidelines for future studies at an experimental level on TGM1 thus mutated. PMID:25180191

  11. A novel mutation in the transglutaminase-1 gene in an autosomal recessive congenital ichthyosis patient.

    PubMed

    Vaigundan, D; Kalmankar, Neha V; Krishnappa, J; Gowda, N Yellappa; Kutty, A V M; Krishnaswamy, Patnam R

    2014-01-01

    Structure-function implication on a novel homozygous Trp250/Gly mutation of transglutaminase-1 (TGM1) observed in a patient of autosomal recessive congenital ichthyosis is invoked from a bioinformatics analysis. Structural consequences of this mutation are hypothesized in comparison to homologous enzyme human factor XIIIA accepted as valid in similar structural analysis and are projected as guidelines for future studies at an experimental level on TGM1 thus mutated. PMID:25180191

  12. Autosomal recessive Duchenne-like muscular dystrophy: molecular and histochemical results.

    PubMed

    McGuire, S A; Fischbeck, K H

    1991-12-01

    An autosomal recessive disorder which mimics Duchenne muscular dystrophy has long been suspected as a cause of muscular dystrophy in karyotypically normal girls and in both boys and girls with consanguineous parents. Analysis of dystrophin now allows confirmation of the existence of this disorder. We report the results of this analysis in a brother and sister who have the typical clinical features of Duchenne muscular dystrophy, but no demonstrable abnormality in dystrophin or its gene. PMID:1766451

  13. CASE REPORT Open Access Autosomal recessive cerebellar ataxia caused

    E-print Network

    Paris-Sud XI, Université de

    (ARCA) include Friedreich ataxia, ataxia telangiectasia and oculomotor apraxia type 1 and 2 [1CASE REPORT Open Access Autosomal recessive cerebellar ataxia caused by mutations in the PEX2 gene Objective: To expand the spectrum of genetic causes of autosomal recessive cerebellar ataxia (ARCA). Case

  14. Children at Play--Behavior of Children at Recess.

    ERIC Educational Resources Information Center

    Kraft, Robert E.

    1989-01-01

    Data from a study involving 369 children (K-3) suggests that the activity patterns during recess and physical education classes are similar. Children do not voluntarily engage in sufficient aerobic activity during recess, nor do physical education programs provide sufficient appropriate activities to adequately promote fitness. (IAH)

  15. Mechanisms of Disease: autosomal dominant and recessive polycystic kidney diseases

    Microsoft Academic Search

    Peter C Harris; Vicente E Torres

    2006-01-01

    Autosomal dominant polycystic kidney disease and autosomal recessive polycystic kidney disease are the best known of a large family of inherited diseases characterized by the development of renal cysts of tubular epithelial cell origin. Autosomal dominant and recessive polycystic kidney diseases have overlapping but distinct pathogeneses. Identification of the causative mutated genes and elucidation of the function of their encoded

  16. Effects of gate recess etching on source resistance

    Microsoft Academic Search

    G. T. Cibuzar

    1995-01-01

    Recessed gate microwave MESFET's and MODFET's have a recessed but unmetallized length L? of the channel adjacent to the gate, whose resistance R? can significantly contribute to the source resistance Rs. The ratio R?\\/R s can be determined using common test structures

  17. An exome sequencing strategy to diagnose lethal autosomal recessive disorders.

    PubMed

    Ellard, Sian; Kivuva, Emma; Turnpenny, Peter; Stals, Karen; Johnson, Matthew; Xie, Weijia; Caswell, Richard; Lango Allen, Hana

    2015-03-01

    Rare disorders resulting in prenatal or neonatal death are genetically heterogeneous. For some conditions, affected fetuses can be diagnosed by ultrasound scan, but this is not usually possible until mid-gestation. There is often limited fetal DNA available for investigation. We investigated a strategy for diagnosing autosomal recessive lethal disorders in non-consanguineous pedigrees with multiple affected fetuses. Exome sequencing was performed to identify genes where each parent is heterozygous for a rare non-synonymous-coding or splicing variant. Putative pathogenic variants were tested for cosegregation in affected fetuses and unaffected siblings. In eight couples of European ancestry, we found on average 1.75 genes (range 0-4) where both parents were heterozygous for rare potentially deleterious variants. A proof-of-principle study detected heterozygous DYNC2H1 variants in a couple whose five fetuses had short-rib polydactyly. Prospective analysis of two couples with multiple pregnancy terminations for fetal akinesia syndrome was performed and a diagnosis was obtained in both the families. The first couple were each heterozygous for a previously reported GLE1 variant, p.Arg569His or p.Val617Met; both were inherited by their two affected fetuses. The second couple were each heterozygous for a novel RYR1 variant, c.14130-2A>G or p.Ser3074Phe; both were inherited by their three affected fetuses but not by their unaffected child. Biallelic GLE1 and RYR1 disease-causing variants have been described in other cases with fetal akinesia syndrome. We conclude that exome sequencing of parental samples can be an effective tool for diagnosing lethal recessive disorders in outbred couples. This permits early prenatal diagnosis in future pregnancies. PMID:24961629

  18. Curve-based multivariate distance matrix regression analysis: application to genetic association analyses involving repeated measures

    PubMed Central

    Salem, Rany M.; O'Connor, Daniel T.

    2010-01-01

    Most, if not all, human phenotypes exhibit a temporal, dosage-dependent, or age effect. Despite this fact, it is rare that data are collected over time or in sequence in relevant studies of the determinants of these phenotypes. The costs and organizational sophistication necessary to collect repeated measurements or longitudinal data for a given phenotype are clearly impediments to this, but greater efforts in this area are needed if insights into human phenotypic expression are to be obtained. Appropriate data analysis methods for genetic association studies involving repeated or longitudinal measures are also needed. We consider the use of longitudinal profiles obtained from fitted functions on repeated data collections from a set of individuals whose similarities are contrasted between sets of individuals with different genotypes to test hypotheses about genetic influences on time-dependent phenotype expression. The proposed approach can accommodate uncertainty of the fitted functions, as well as weighting factors across the time points, and is easily extended to a wide variety of complex analysis settings. We showcase the proposed approach with data from a clinical study investigating human blood vessel response to tyramine. We also compare the proposed approach with standard analytic procedures and investigate its robustness and power via simulation studies. The proposed approach is found to be quite flexible and performs either as well or better than traditional statistical methods. PMID:20423962

  19. Cone-beam computed tomography analysis of curved root canals after mechanical preparation with three nickel-titanium rotary instruments.

    PubMed

    Elsherief, Samia M; Zayet, Mohamed K; Hamouda, Ibrahim M

    2013-07-01

    Cone beam computed tomography is a 3-dimensional high resolution imaging method. The purpose of this study was to compare the effects of 3 different NiTi rotary instruments used to prepare curved root canals on the final shape of the curved canals and total amount of root canal transportation by using cone-beam computed tomography. A total of 81 mesial root canals from 42 extracted human mandibular molars, with a curvature ranging from 15 to 45 degrees, were selected. Canals were randomly divided into 3 groups of 27 each. After preparation with Protaper, Revo-S and Hero Shaper, the amount of transportation and centering ability that occurred were assessed by using cone beam computed tomography. Utilizing pre- and post-instrumentation radiographs, straightening of the canal curvatures was determined with a computer image analysis program. Canals were metrically assessed for changes (surface area, changes in curvature and transportation) during canal preparation by using software SimPlant; instrument failures were also recorded. Mean total widths and outer and inner width measurements were determined on each central canal path and differences were statistically analyzed. The results showed that all instruments maintained the original canal curvature well with no significant differences between the different files (P = 0.226). During preparation there was failure of only one file (the protaper group). In conclusion, under the conditions of this study, all instruments maintained the original canal curvature well and were safe to use. Areas of uninstrumented root canal wall were left in all regions using the various systems. PMID:23885273

  20. Spatial variation of storage capacity and winter recession in the alpine Poschiavino catchment / Switzerland

    NASA Astrophysics Data System (ADS)

    Floriancic, Marius; Smoorenburg, Maarten; Margreth, Michael; Naef, Felix

    2015-04-01

    Better understanding of the spatial variability of recession and storage dynamics in alpine catchments may improve low flow estimation. Especially in areas with little gauging information, mapping water storing sediments and rocks may help identifying areas responsible for sustaining baseflow during low flow periods. In alpine catchments, low flow occurs during winter, because groundwater recharge from precipitation or snowmelt is limited. This provides good opportunities for research on storage behavior. We present a dataset of winter discharge measurements and water chemistry analyses in the alpine Poschiavino River, a 14km² watershed in southeast Switzerland with strongly contrasting subcatchments. To explore how low flow recession relates to the spatial organization of storage potential, geomorphology and sediment type were mapped. From 7 measurement campaigns throughout winter season 2013/14 we derived recession curves for various nested subcatchments. To identify different contributing sources, the discharge measurements were complemented with ion composition analyses of stream water and continuous hourly electric conductivity measurements. This dataset allowed identifying areas contributing during low flow periods and estimating the storage potential of different subcatchments. We found substantial variation in the contribution of different subcatchments from 54mm to 200mm in four months. The spatial variation of discharge and different drainage time scales in the various subcatchments could be attributed to storage properties like thickness of the sediment deposits. Contribution from areas with thick sediment cover is significantly higher than from parts with less deep deposits. However the spatial resolution of research was limited because of complicated subsurface flow paths. Topographic catchment borders did not always correspond to the hydrological ones. This first study on the relation of low flow recession and storage potential represents an essential basis for developing and adopting storage-based low flow prediction models.

  1. Blast response of curved carbon/epoxy composite panels: Experimental study and finite-element analysis

    NASA Astrophysics Data System (ADS)

    Phadnis, V. A.; Kumar, P.; Shukla, A.; Roy, A.; Silberschmidt, V. V.

    2013-07-01

    Experimental and numerical studies were conducted to understand the effect of plate curvature on blast response of carbon/epoxy composite panels. A shock-tube system was utilized to impart controlled shock loading to quasi-isotropic composite panels with differing range of radii of curvatures. A 3D Digital Image Correlation (DIC) technique coupled with high-speed photography was used to obtain out-of-plane deflection and velocity, as well as in-plane strain on the back face of the panels. Macroscopic post-mortem analysis was performed to compare yielding and deformation in these panels. A dynamic computational simulation that integrates fluid-structure interaction was conducted to evaluate the panel response in general purpose finite-element software ABAQUS/Explicit. The obtained numerical results were compared to the experimental data and showed a good correlation.

  2. What can we learn from the Fourier analysis of blazar light curves?

    NASA Astrophysics Data System (ADS)

    Finke, Justin; Becker, Peter A.

    2014-08-01

    Blazars display strong variability on multiple timescales and in multiple radiation bands. Their variability can be characterized by power spectral densities (PSDs) and time lags as a function of Fourier frequency. We develop a new theoretical model based on analysis of the electron continuity equation carried out in the Fourier domain. This model predicts features in the synchrotron, synchrotron self-Compton (SSC), and external Compton (EC) PSDs and time lags associated with electron cooling, escape, and light travel time effects across the electromagnetic spectrum, from sub-mm to gamma-rays. We also find that FSRQs should have steeper PSD power-law indices than BL Lac objects at low Fourier frequencies if FSRQs produce gamma-rays by EC and BL Lac objects by SSC emission, in qualitative agreement with reported observations by the Fermi Large Area Telescope.

  3. New data analysis of probabilistic stress-life ( P– S– N) curve and its application for structural materials

    Microsoft Academic Search

    Shigeo Shimizu; Katsuji Tosha; Kazuo Tsuchiya

    2010-01-01

    Conventional S–N fatigue curves, the so-called Wöhler curves are generally considered as the experimental fatigue life plots for several stress amplitudes. The curves are usually expressed as median ranks and each life distribution is supposed to follow the log-normal distributions. Therefore, it can be said that not enough work on the theoretical relationship between the life distributions and the S–N

  4. Detection of monoclonal immunoglobulin heavy chain gene rearrangement (FR3) in Thai malignant lymphoma by High Resolution Melting curve analysis

    PubMed Central

    2010-01-01

    Abstract Malignant lymphoma, especially non-Hodgkin lymphoma, is one of the most common hematologic malignancies in Thailand. The diagnosis of malignant lymphoma is often problematic, especially in early stages of the disease. Detection of antigen receptor gene rearrangement including T cell receptor (TCR) and immunoglobulin heavy chain (IgH) by polymerase chain reaction followed by heteroduplex has currently become standard whereas fluorescent fragment analysis (GeneScan) has been used for confirmation test. In this study, three techniques had been compared: thermocycler polymerase chain reaction (PCR) followed by heteroduplex and polyacrylamide gel electrophoresis, GeneScan analysis, and real time PCR with High Resolution Melting curve analysis (HRM). The comparison was carried out with DNA extracted from paraffin embedded tissues diagnosed as B- cell non-Hodgkin lymphoma. Specific PCR primers sequences for IgH gene variable region 3, including fluorescence labeled IgH primers were used and results were compared with HRM. In conclusion, the detection IgH gene rearrangement by HRM in the LightCycler System showed potential for distinguishing monoclonality from polyclonality in B-cell non-Hodgkin lymphoma. Introduction Malignant lymphoma, especially non-Hodgkin lymphoma, is one of the most common hematologic malignancies in Thailand. The incidence rate as reported by Ministry of Public Health is 3.1 per 100,000 population in female whereas the rate in male is 4.5 per 100,000 population [1]. At Siriraj Hospital, the new cases diagnosed as malignant lymphoma were 214.6 cases/year [2]. The diagnosis of malignant lymphoma is often problematic, especially in early stages of the disease. Therefore, detection of antigen receptor gene rearrangement including T cell receptor (TCR) and immunoglobulin heavy chain (IgH) by polymerase chain reaction (PCR) assay has recently become a standard laboratory test for discrimination of reactive from malignant clonal lymphoproliferation [3,4]. Analyzing DNA extracted from formalin-fixed, paraffin-embedded tissues by multiplex PCR techniques is more rapid, accurate and highly sensitive. Measuring the size of the amplicon from PCR analysis could be used to diagnose malignant lymphoma with monoclonal pattern showing specific and distinct bands detected on acrylamide gel electrophoresis. However, this technique has some limitations and some patients might require a further confirmation test such as GeneScan or fragment analysis [5,6]. GeneScan technique or fragment analysis reflects size and peak of DNA by using capillary gel electrophoresis. This technique is highly sensitive and can detect 0.5-1% of clonal lymphoid cells. It measures the amplicons by using various fluorescently labeled primers at forward or reverse sides and a specific size standard. Using a Genetic Analyzer machine and GeneMapper software (Applied Bioscience, USA), the monoclonal pattern revealed one single, sharp and high peak at the specific size corresponding to acrylamide gel pattern, whereas the polyclonal pattern showed multiple and small peak condensed at the same size standard. This technique is the most sensitive and accurate technique; however, it usually requires high technical experience and is also of high cost [7]. Therefore, rapid and more cost effective technique are being sought. LightCycler PCR performs the diagnostic detection of amplicon via melting curve analysis within 2 hours with the use of a specific dye [8,9]. This dye consists of two types: one known as SYBR-Green I which is non specific and the other named as High Resolution Melting analysis (HRM) which is highly sensitive, more accurate and stable. Several reports demonstrated that this new instrument combined with DNA intercalating dyes can be used to discriminate sequence changes in PCR amplicon without manual handling of PCR product [10,11]. Therefore, current investigations using melting curve analysis are being developed [12,13]. In this study, three different techniques were compared to evaluate the suitability of LightCycler PCR with HRM as

  5. Single nucleotide polymorphism genotyping by two colour melting curve analysis using the MGB Eclipse™ Probe System in challenging sequence environment

    PubMed Central

    2004-01-01

    Probe and primer design for single nucleotide polymorphism (SNP) detection can be very challenging for A-T DNA-rich targets, requiring long sequences with lower specificity and stability, while G-C-rich DNA targets present limited design options to lower GC-content sequences only. We have developed the MGB Eclipsee™ Probe System, which is composed of the following elements: MGB Eclipse probes and primers, specially developed software for the design of probes and primers, a unique set of modified bases and a Microsoft Excel macro for automated genotyping, which ably solves, in large part, this challenge. Fluorogenic MGB Eclipse probes are modified oligo-nucleotides containing covalently attached duplex-stabilising dihydrocyclopyrroloindole tripeptide (DPI3), the MGB ligand (MGB™ is a trademark of Epoch Biosciences, Bothell, WA), which has the combined properties of allowing the use of short sequences and providing great mismatch discrimination. The MGB moiety prevents probe degradation during polymerase chain reaction (PCR), allowing the researcher to use real time data; alternatively, hybridisation can be accurately measured by a post-PCR two-colour melt curve analysis. Using MGB Eclipse probes and primers containing modified bases further enhances the analysis of difficult SNP targets. G- or C-rich sequences can be refractory to analysis due to Hoogsteen base pairing. Substitution of normal G with Epoch's modified G prevents Hoogsteen base pairing, allowing both superior PCR and probe-based analysis of GC-rich targets. The use of modified A and T bases allows better stabilisation by significantly increasing the Tm of the oligonucleotides. Modified A creates A-T base pairs that have a stability slightly lower than a G-C base pair, and modified T creates T-A base pairs that have a stability about 30 per cent higher than the unmodified base pair. Together, the modified bases permit the use of short probes, providing good mismatch discrimination and primers that allow PCR of refractory targets. The combination of MGB Eclipse probes and primers enriched with the MGB ligand and modified bases has allowed the analysis of refractory SNPs, where other methods have failed. PMID:15588480

  6. A Biometric Latent Curve Analysis of Memory Decline in Older Men of the NAS-NRC Twin Registry

    PubMed Central

    McArdle, John J.; Plassman, Brenda L.

    2010-01-01

    Previous research has shown cognitive abilities to have different biometric patterns of age-changes. Here we examined the variation in episodic memory (Words Recalled) for over 6,000 twin pairs who were initially aged 59-75, and were subsequently re-assessed up to three more times over 12 years. In cross-sectional analyses, variation in Education was explained by strong additive genetic influences (~43%) together with shared family influences (~35%) that were independent of age. The longitudinal phenotypic analysis of the Word Recall task showed systematic linear declines over age, but with positive influences of Education and Retesting. The longitudinal biometric estimation yielded: (a) A separation of non-shared environmental influences and transient measurement error (~50%): (b) Strong additive genetic components of this latent curve (~70% at age 60) with increases over age that reach about 90% by age 90. (c) The minor influences of shared family environment (~17% at age 60) were effectively eliminated by age 75. (d) Non-shared environmental effects play an important role over most of the life-span (peak of 42% at age 70) but their relative role diminishes after age 75. PMID:19404731

  7. Validation of Kepler's multiple planet candidates. III. Light curve analysis and announcement of hundreds of new multi-planet systems

    SciTech Connect

    Rowe, Jason F.; Bryson, Stephen T.; Lissauer, Jack J.; Jontof-Hutter, Daniel; Mullally, Fergal; Howell, Steve B.; Borucki, William J.; Haas, Michael; Huber, Daniel; Thompson, Susan E.; Quintana, Elisa; Barclay, Thomas; Still, Martin [NASA Ames Research Center, Moffett Field, CA 94035 (United States); Marcy, Geoffrey W.; Issacson, Howard [University of California, Berkeley, CA 94720 (United States); Gilliland, Ronald L. [Center for Exoplanets and Habitable Worlds, The Pennsylvania State University, University Park, PA 16802 (United States); Ford, Eric [Pennsylvania State University, PA 16801 (United States); Steffen, Jason H. [Northwestern University, Department of Physics and Astronomy/CIERA, 2145 Sheridan Road, Evanston, IL 60208 (United States); Fortney, Jonathan [Department of Astronomy and Astrophysics, University of California, Santa Cruz, CA 95064 (United States); Gautier, T. N. III, E-mail: Jason.Rowe@nasa.gov [Jet Propulsion Laboratory, California Institute of Technology (United States); and others

    2014-03-20

    The Kepler mission has discovered more than 2500 exoplanet candidates in the first two years of spacecraft data, with approximately 40% of those in candidate multi-planet systems. The high rate of multiplicity combined with the low rate of identified false positives indicates that the multiplanet systems contain very few false positive signals due to other systems not gravitationally bound to the target star. False positives in the multi-planet systems are identified and removed, leaving behind a residual population of candidate multi-planet transiting systems expected to have a false positive rate less than 1%. We present a sample of 340 planetary systems that contain 851 planets that are validated to substantially better than the 99% confidence level; the vast majority of these have not been previously verified as planets. We expect ?two unidentified false positives making our sample of planet very reliable. We present fundamental planetary properties of our sample based on a comprehensive analysis of Kepler light curves, ground-based spectroscopy, and high-resolution imaging. Since we do not require spectroscopy or high-resolution imaging for validation, some of our derived parameters for a planetary system may be systematically incorrect due to dilution from light due to additional stars in the photometric aperture. Nonetheless, our result nearly doubles the number verified exoplanets.

  8. Development and analysis of regional curves for streams in the non-urban valley and ridge physiographic province, Maryland, Virginia, and West Virginia

    USGS Publications Warehouse

    Keaton, Jefferson N.; Messinger, Terence; Doheny, Edward J.

    2005-01-01

    Regression relations for bankfull stream characteristics based on drainage area (often called 'regional curves') are used in natural stream channel design to verify field determinations of bankfull discharge and stream channel characteristics. Bankfull stream characteristics were assessed for stream reaches at 41 streamflow-gaging stations in the Valley and Ridge Physiographic Province in Maryland, Virginia, and West Virginia. Data collected included bankfull cross-sectional geometry, flood plain geometry, and longitudinal profile data. In addition, particle-size distributions of streambed material were determined and data on basin characteristics were compiled for each reach. Regional curves were developed for bankfull cross-sectional area, width, and discharge with R2 values of 0.95, 0.89, 0.87, and 0.91, respectively. Examination of the regional curves residuals indicates that there is more variability in bankfull cross-sectional area, width, and discharge for smaller streams than for larger streams. In contrast, there is more variability for bankfull mean depth for larger streams than for smaller streams. Geographic analysis of regional curve residuals indicated that there were no further subdivisions within the Valley and Ridge Physiographic Province in the three-state study area for which individual sets of regional curves should be developed. In addition, two separate sets of regional curves were developed with data from the 41 sites to examine potential differences in the relations between the southern (n = 9) and central (n = 32) sections of the province. There were differences in slope and intercept between the two bankfull discharge test relations and a difference in intercept for the width test relations at the 95-percent confidence level. However, the results of this analysis were inconclusive and therefore one set of regional curves for the study area is presented in this report. The regional curves were compared to regression models developed from similar data collected in the Pennsylvania and Maryland portions of the province. No statistical difference in the slope or intercept of regression lines of the three data sets was detected for any of the four bankfull parameters at the 95-percent confidence level. Basin characteristics such as percentage of basin forested (percent forested) and percentage of basin underlain by carbonate bedrock (percent carbonate) were analyzed to evaluate variability among regression points. Multivariate regression relations including explanatory terms for percent carbonate and drainage area produced higher R2 values than the regional curves for bankfull cross-sectional area (R2 = 0.95), bankfull width (R2 = 0.92), and bankfull discharge (R2 = 0.93). There was no improvement for the bankfull mean depth relation from adding the additional term. Inclusion of the other basin characteristics in multivariate relations did not improve the regression models. Regression models developed for the 1.5-year discharge for all streamflow-gaging stations with peak discharge data throughout Virginia (n = 486) and throughout the Valley and Ridge Physiographic Province in Virginia (n = 147) were compared to the regional curve relating bankfull discharge to drainage area. A similar trend in decreasing variability with increasing drainage area was observed for the 1.5-year discharge for all stations in Virginia . This indicates that the change in variability observed in the discharge regional curve likely would exist with a larger data set. There was no statistical difference at the 95-percent confidence level between regression relations for the southern section of the province (n = 40) and the central section (n = 107). This finding supports maintaining only one set of regional curves for the study area. Not all of the variability in the regional curves is explained by drainage area alone. Causes of the remaining variability likely vary among study sites. Users of the regional curves de

  9. Mitotic recombination in Candida albicans : Recessive lethal alleles linked to a gene required for methionine biosynthesis

    Microsoft Academic Search

    William L. Whelan; David R. Soll

    1982-01-01

    Genetic analysis by ultraviolet-induced mitotic segregation indicated that Candida albicans wild-type strain Ca526 was heterozygous at a gene (MET) required for biosynthesis of methionine. The MET gene was shown to be linked to two other genes (LET1, LET2) whose recessive alleles (let1, let2) each determined lethality when homozygous. The phenotype determined by let1 was temperaturesensitive. The inferred genotype of strain

  10. Detecting differential allelic expression using high-resolution melting curve analysis: application to the breast cancer susceptibility gene CHEK2

    PubMed Central

    2011-01-01

    Background The gene CHEK2 encodes a checkpoint kinase playing a key role in the DNA damage pathway. Though CHEK2 has been identified as an intermediate breast cancer susceptibility gene, only a small proportion of high-risk families have been explained by genetic variants located in its coding region. Alteration in gene expression regulation provides a potential mechanism for generating disease susceptibility. The detection of differential allelic expression (DAE) represents a sensitive assay to direct the search for a functional sequence variant within the transcriptional regulatory elements of a candidate gene. We aimed to assess whether CHEK2 was subject to DAE in lymphoblastoid cell lines (LCLs) from high-risk breast cancer patients for whom no mutation in BRCA1 or BRCA2 had been identified. Methods We implemented an assay based on high-resolution melting (HRM) curve analysis and developed an analysis tool for DAE assessment. Results We observed allelic expression imbalance in 4 of the 41 LCLs examined. All four were carriers of the truncating mutation 1100delC. We confirmed previous findings that this mutation induces non-sense mediated mRNA decay. In our series, we ruled out the possibility of a functional sequence variant located in the promoter region or in a regulatory element of CHEK2 that would lead to DAE in the transcriptional regulatory milieu of freely proliferating LCLs. Conclusions Our results support that HRM is a sensitive and accurate method for DAE assessment. This approach would be of great interest for high-throughput mutation screening projects aiming to identify genes carrying functional regulatory polymorphisms. PMID:21569354

  11. Other autosomal recessive and childhood ataxias.

    PubMed

    De Michele, Giuseppe; Filla, Alessandro

    2012-01-01

    The label of "early-onset cerebellar ataxia with retained tendon reflexes" (EOCA) has been created to differentiate it from Friedreich ataxia (FRDA) patients with preserved knee jerks and absence of cardiomyopathy, optic atrophy, and diabetes mellitus. However, EOCA is a heterogeneous syndrome and several FRDA patients present with an EOCA-like phenotype. Cerebellar ataxia with hypogonadism is another heterogeneous syndrome for which no locus has been mapped yet. Two peculiar ataxic syndromes have been identified in genetically isolated populations: autosomal recessive ataxia of Charlevoix-Saguenay (ARSACS) in Quebec and infantile-onset spinocerebellar ataxia (IOSCA) in Finland. Both conditions present usually within the second year of life. ARSACS is characterized by marked spasticity and IOSCA by a complex phenotype which includes, besides ataxia, epilepsy, optic atrophy, ophthalmoplegia, hearing loss, and areflexia. The responsible genes are SACS, encoding sacsin, a protein which may act as a chaperone, and C10orf2, encoding Twinkle, a mitochondrial DNA-specific helicase. Marinesco-Sjögren syndrome, clinically characterized by cerebellar ataxia, cataracts, myopathy, and mental retardation, is genetically heterogeneous. One gene, SIL1, encodes a nucleotide exchange factor for the heat-shock protein 70 chaperone HSPA5. Five conditions account for most cases of progressive myoclonic ataxia: Unverricht-Lundborg disease, Lafora disease, myoclonic epilepsy with ragged-red fibers, neuronal ceroid lipofuscinoses, and sialidoses. PMID:21827899

  12. Clarifications regarding the use of model-fitting methods of kinetic analysis for determining the activation energy from a single non-isothermal curve

    PubMed Central

    2013-01-01

    Background This paper provides some clarifications regarding the use of model-fitting methods of kinetic analysis for estimating the activation energy of a process, in response to some results recently published in Chemistry Central journal. Findings The model fitting methods of Arrhenius and Savata are used to determine the activation energy of a single simulated curve. It is shown that most kinetic models correctly fit the data, each providing a different value for the activation energy. Therefore it is not really possible to determine the correct activation energy from a single non-isothermal curve. On the other hand, when a set of curves are recorded under different heating schedules are used, the correct kinetic parameters can be clearly discerned. Conclusions Here, it is shown that the activation energy and the kinetic model cannot be unambiguously determined from a single experimental curve recorded under non isothermal conditions. Thus, the use of a set of curves recorded under different heating schedules is mandatory if model-fitting methods are employed. PMID:23383684

  13. Recess: an Essential Part of The School Day

    MedlinePLUS

    Recess: An Essential Part of the School Day Study shows supervised play boosts teamwork, friendships and positive attitudes To use the sharing features on this page, please enable JavaScript. (*this news ...

  14. Chemical-mechanical polishing of recessed microelectromechanical devices

    DOEpatents

    Barron, C.C.; Hetherington, D.L.; Montague, S.

    1999-07-06

    A method is disclosed for micromachining recessed layers (e.g. sacrificial layers) of a microelectromechanical system (MEMS) device formed in a cavity etched into a semiconductor substrate. The method uses chemical-mechanical polishing (CMP) with a resilient polishing pad to locally planarize one or more of the recessed layers within the substrate cavity. Such local planarization using the method of the present invention is advantageous for improving the patterning of subsequently deposited layers, for eliminating mechanical interferences between functional elements (e.g. linkages) of the MEMS device, and for eliminating the formation of stringers. After the local planarization of one or more of the recessed layers, another CMP step can be provided for globally planarizing the semiconductor substrate to form a recessed MEMS device which can be integrated with electronic circuitry (e.g., CMOS, BiCMOS or bipolar circuitry) formed on the surface of the substrate. 23 figs.

  15. Large linkage analysis in 100 families with autosomal recessive spinal muscular atrophy (SMA) and 11 EPH families using 15 polymorphic loci in the region 5q11. 2-q13. 3

    SciTech Connect

    Wirth, B.; Pick, E.; Leutner, A.; Dadze, A.; Voosen, B.; Piechaczek-Wappenschmidt, B.; Rudnik-Schoeneborn, S.; Schoenling, J.; Zerres, K. (Institute of Human Genetics, Bonn (Germany)); Knapp, M. (Institute of Medical Statistics, Bonn (Germany)) (and others)

    1994-03-01

    The autosomal recessive proximal spinal muscular atrophy (SMA) gene was mapped to the region 5q11.2-q.13.3 in 1990. Here, the authors present a large genetic linkage study of 100 SMA families and 11 CEPH families using 14 polymorphic simple sequence repeats (SSRs) and one RFLP in the region 5q11.2-q.13.3. The genetic interval between the closest SMA flanking loci D5S435 and D5S557 comprises 1 cM at z[sub max] = 27.94. Two recombinants were identified between the SMA gene and the closest telomeric marker D5S557. The first places the SMA gene centromeric to this marker; the second suggests a double recombinant at D5S557, which is very unlikely. More likely explanations are discussed in the paper. No recombinant was found between D5S435 and the SMA gene. They localized a recently described polymorphic marker, D5S351, close to the SMA. Due to its high PIC value of 0.70, it represents a very useful marker for prenatal diagnosis. In addition, they developed a new reverse primer for the nearest centromeric locus D5S435, a useful marker for prenatal diagnosis, which has been very difficult to amplify in the past. Three of the markers presented here are newly developed polymorphic SSRs (one tetranucleotide repeat, D5s507/W15CATT, and two dinucleotide repeats, D5S544/C88.2GT and D5S682/C88.3GT). These markers are too far from the SMA gene to be relevant for cloning; nevertheless, as part of the human genome project, they are contributing to the fine genetic mapping of the region 5q11.2-q.13.3. The most likely order of the loci based on two-point and multipoint linkage analyses as well as on specific recombination events and physical mapping studies is D5S76-D5S507-D5S6-D5S125-D5S680-D5S435-SMA-D5S557-D5S35 -15[prime]MAP1B-3[prime]MAP1B-JK53CA1/2-(D5S127-D5S39)-(D5S544-D5S682). In general, the genetic distances obtained from the SMA and CEPH families are comparable. 25 refs., 4 figs., 5 tabs.

  16. Children's Physical Activity during Recess and Outside of School

    ERIC Educational Resources Information Center

    Beighle, Aaron; Morgan, Charles F.; Le Masurier, Guy; Pangrazi, Robert P.

    2006-01-01

    The purpose of this study was to examine children's physical activity during recess and outside of school. Third-, fourth-, and fifth-grade students (N = 270; 121 boys, age = 9.5 plus or minus 0.9 years; 150 girls, age = 9.6 plus or minus 0.9 years) wore sealed pedometers during a 15-minute recess period and outside of school for 4 consecutive…

  17. Recession of the inferior rectus muscle in Graves’ orbitopathy

    Microsoft Academic Search

    J De Hoog; S Stravers; R Kalmann

    2010-01-01

    PurposeTo identify the predictive factors for overcorrection and depression impairment after recession of the inferior rectus muscle (IRM) in patients with Graves’ orbitopathy.DesignRetrospective cohort study, single institution.MethodsThe charts of 124 consecutive patients who underwent recession of the IRM were retrospectively examined, as well as all literature with regard to the subject until January 2008. Ductions measurements, computed tomography (CT) appearance,

  18. Production Recesses for Replaceable Cutting Inserts of Milling Tools

    NASA Astrophysics Data System (ADS)

    Kousal, Lukáš; Sadílek, Marek

    2014-12-01

    This article describes the production of recesses for replaceable cutting inserts of milling tools. The recess manufacture is exemplified on a D20 shanktype milling cutter with three replaceable cutting inserts. A new production technology and its operating cycle are demonstrated. A com-parison of the old and the new technologies shows the percentage saving of change cycles and used tools, including overall evaluation of the tech-nology.

  19. Experts offer differing views on the impact of a recession.

    PubMed

    Anderson, H J

    1990-12-01

    What are the risks of a prolonged recession for hospitals? Although health care would probably not be hurt as much as other industries by a lengthy downturn, financial experts are saying a continuation of the current soft economy would add to hospitals' already long list of financial woes. The coming recession "will exacerbate the problems for hospitals already facing fiscal stress," says Glenn Wagner, an investment banking consultant based in New York City. PMID:2242892

  20. Gas insulated transmission line with insulators having field controlling recesses

    DOEpatents

    Cookson, Alan H. (Pittsburgh, PA); Pederson, Bjorn O. (Chelmsford, MA)

    1984-01-01

    A gas insulated transmission line having a novel insulator for supporting an inner conductor concentrically within an outer sheath. The insulator has a recess contiguous with the periphery of one of the outer and inner conductors. The recess is disposed to a depth equal to an optimum gap for the dielectric insulating fluid used for the high voltage insulation or alternately disposed to a large depth so as to reduce the field at the critical conductor/insulator interface.

  1. Recessive resistance genes against potyviruses are localized in colinear genomic regions of the tomato ( Lycopersicon spp.) and pepper ( Capsicum spp.) genomes

    Microsoft Academic Search

    G. Parrella; S. Ruffel; A. Moretti; C. Morel; A. Palloix; C. Caranta

    2002-01-01

    Resistance against both Potato virus Y (PVY) and Tobacco etch virus (TEV) was identified in the wild tomato relative Lycopersicon hirsutum PI247087. Analysis of the segregation ratio in F2\\/F3 and BC1 interspecific progenies indicated that a single recessive gene, or two very tightly linked recessive loci, are involved in resistance to both potyviruses. This locus was named pot-1. Using amplified

  2. Quantitative Fundus Autofluorescence in Recessive Stargardt Disease

    PubMed Central

    Burke, Tomas R.; Duncker, Tobias; Woods, Russell L.; Greenberg, Jonathan P.; Zernant, Jana; Tsang, Stephen H.; Smith, R. Theodore; Allikmets, Rando; Sparrow, Janet R.; Delori, François C.

    2014-01-01

    Purpose. To quantify fundus autofluorescence (qAF) in patients with recessive Stargardt disease (STGD1). Methods. A total of 42 STGD1 patients (ages: 7–52 years) with at least one confirmed disease-associated ABCA4 mutation were studied. Fundus AF images (488-nm excitation) were acquired with a confocal scanning laser ophthalmoscope equipped with an internal fluorescent reference to account for variable laser power and detector sensitivity. The gray levels (GLs) of each image were calibrated to the reference, zero GL, magnification, and normative optical media density to yield qAF. Texture factor (TF) was calculated to characterize inhomogeneities in the AF image and patients were assigned to the phenotypes of Fishman I through III. Results. Quantified fundus autofluorescence in 36 of 42 patients and TF in 27 of 42 patients were above normal limits for age. Young patients exhibited the relatively highest qAF, with levels up to 8-fold higher than healthy eyes. Quantified fundus autofluorescence and TF were higher in Fishman II and III than Fishman I, who had higher qAF and TF than healthy eyes. Patients carrying the G1916E mutation had lower qAF and TF than most other patients, even in the presence of a second allele associated with severe disease. Conclusions. Quantified fundus autofluorescence is an indirect approach to measuring RPE lipofuscin in vivo. We report that ABCA4 mutations cause significantly elevated qAF, consistent with previous reports indicating that increased RPE lipofuscin is a hallmark of STGD1. Even when qualitative differences in fundus AF images are not evident, qAF can elucidate phenotypic variation. Quantified fundus autofluorescence will serve to establish genotype-phenotype correlations and as an outcome measure in clinical trials. PMID:24677105

  3. High-throughput avian molecular sexing by SYBR green-based real-time PCR combined with melting curve analysis

    PubMed Central

    Chang, Hsueh-Wei; Cheng, Chun-An; Gu, De-Leung; Chang, Chia-Che; Su, San-Hua; Wen, Cheng-Hao; Chou, Yii-Cheng; Chou, Ta-Ching; Yao, Cheng-Te; Tsai, Chi-Li; Cheng, Chien-Chung

    2008-01-01

    Background Combination of CHD (chromo-helicase-DNA binding protein)-specific polymerase chain reaction (PCR) with electrophoresis (PCR/electrophoresis) is the most common avian molecular sexing technique but it is lab-intensive and gel-required. Gender determination often fails when the difference in length between the PCR products of CHD-Z and CHD-W genes is too short to be resolved. Results Here, we are the first to introduce a PCR-melting curve analysis (PCR/MCA) to identify the gender of birds by genomic DNA, which is gel-free, quick, and inexpensive. Spilornis cheela hoya (S. c. hoya) and Pycnonotus sinensis (P. sinensis) were used to illustrate this novel molecular sexing technique. The difference in the length of CHD genes in S. c. hoya and P. sinensis is 13-, and 52-bp, respectively. Using Griffiths' P2/P8 primers, molecular sexing failed both in PCR/electrophoresis of S. c. hoya and in PCR/MCA of S. c. hoya and P. sinensis. In contrast, we redesigned sex-specific primers to yield 185- and 112-bp PCR products for the CHD-Z and CHD-W genes of S. c. hoya, respectively, using PCR/MCA. Using this specific primer set, at least 13 samples of S. c. hoya were examined simultaneously and the Tm peaks of CHD-Z and CHD-W PCR products were distinguished. Conclusion In this study, we introduced a high-throughput avian molecular sexing technique and successfully applied it to two species. This new method holds a great potential for use in high throughput sexing of other avian species, as well. PMID:18269737

  4. Recessive mutations in EPG5 cause Vici syndrome, a multisystem disorder with defective autophagy

    PubMed Central

    Cullup, Thomas; Kho, Ay L.; Dionisi-Vici, Carlo; Brandmeier, Birgit; Smith, Frances; Urry, Zoe; Simpson, Michael A.; Yau, Shu; Bertini, Enrico; McClelland, Verity; Al-Owain, Mohammed; Koelker, Stefan; Koerner, Christian; Hoffmann, Georg F.; Wijburg, Frits A.; Hoedt, Amber E. ten; Rogers, Curtis; Manchester, David; Miyata, Rie; Hayashi, Masaharu; Said, Elizabeth; Soler, Doriette; Kroisel, Peter M.; Windpassinger, Christian; Filloux, Francis M.; Al-Kaabi, Salwa; Hertecant, Jozef; Del Campo, Miguel; Buk, Stefan; Bodi, Istvan; Goebel, Hans-Hilmar; Sewry, Caroline A.; Abbs, Stephen; Mohammed, Shehla; Josifova, Dragana; Gautel, Mathias; Jungbluth, Heinz

    2012-01-01

    Vici syndrome is a recessively inherited multisystem disorder characterized by callosal agenesis, cataracts, cardiomyopathy, combined immunodeficiency and hypopigmentation. To investigate the molecular basis of Vici syndrome, we carried out exome and Sanger sequence analysis in a cohort of 18 patients. We identified recessive mutations in EPG5 (previously KIAA1632), indicating a causative role in Vici syndrome. EPG5 is the human homologue of the metazoan-specific autophagy gene epg-5, encoding a key autophagy regulator (ectopic P-granules autophagy protein 5) implicated in the formation of autolysosomes. Further studies demonstrated a severe block of autophagosomal clearance in muscle and fibroblasts from EPG5 mutant patients, resulting in autophagic cargo accumulation in autophagosomes. These findings indicate Vici syndrome as a paradigm of a human multisystem disorder associated with defective autophagy, and suggest a fundamental role of the autophagy pathway in the anatomical and functional formation of organs such as the brain, the heart and the immune system. PMID:23222957

  5. Introduction Elliptic curves

    E-print Network

    Kwak, Do Young

    Introduction Elliptic curves Modular curves Elliptic curves and modular forms Application to number theory y-coordinates of elliptic curves Dong Hwa Shin Department of Mathematical Sciences KAIST January 11, 2010 #12;Introduction Elliptic curves Modular curves Elliptic curves and modular forms

  6. Rapid Detection of Isoniazid Resistance in Mycobacterium tuberculosis Isolates by Use of Real-Time-PCR-Based Melting Curve Analysis

    PubMed Central

    Hu, Siyu; Li, Guoli; Li, Hui; Liu, Xiaoli; Niu, Jianjun; Quan, Shengmao; Wang, Feng; Wen, Huixin

    2014-01-01

    The MeltPro TB/INH assay, recently approved by the Chinese Food and Drug Administration, is a closed-tube, dual-color, melting curve analysis-based, real-time PCR test specially designed to detect 30 isoniazid (INH) resistance mutations in katG position 315 (katG 315), the inhA promoter (positions ?17 to ?8), inhA position 94, and the ahpC promoter (positions ?44 to ?30 and ?15 to 3) of Mycobacterium tuberculosis. Here we evaluated both the analytical performance and clinical performance of this assay. Analytical studies with corresponding panels demonstrated that the accuracy for detection of different mutation types (10 wild-type samples and 12 mutant type samples), the limit of detection (2 × 103 to 2 × 104 bacilli/ml), reproducibility (standard deviation [SD], <0.4°C), and the lowest heteroresistance level (40%) all met the parameters preset by the kit. The assay could be run on five types of real-time PCR machines, with the shortest running time (105 min) obtained with the LightCycler 480 II. Clinical studies enrolled 1,096 clinical isolates collected from three geographically different tuberculosis centers, including 437 INH-resistant isolates and 659 INH-susceptible isolates characterized by traditional drug susceptibility testing on Löwenstein-Jensen solid medium. The clinical sensitivity and specificity of the MeltPro TB/INH assay were 90.8% and 96.4%, respectively. DNA sequencing analysis showed that, except for the 5 mutants outside the detection range of the MeltPro assay, a concordance rate between the two methods of 99.1% (457/461) was obtained. Among the 26 mutation types detected, katG S315T (AGC?ACC), inhA ?15C?T, katG S315N (AGC?AAC), and ahpC promoter ?10C?T accounted for more than 90%. Overall, the MeltPro TB/INH assay represents a reliable and rapid tool for the detection of INH resistance in clinical isolates. PMID:24599986

  7. Recessive truncating titin gene, TTN, mutations presenting as centronuclear myopathy

    PubMed Central

    Ceyhan-Birsoy, Ozge; Agrawal, Pankaj B.; Hidalgo, Carlos; Schmitz-Abe, Klaus; DeChene, Elizabeth T.; Swanson, Lindsay C.; Soemedi, Rachel; Vasli, Nasim; Iannaccone, Susan T.; Shieh, Perry B.; Shur, Natasha; Dennison, Jane M.; Lawlor, Michael W.; Laporte, Jocelyn; Markianos, Kyriacos; Fairbrother, William G.; Granzier, Henk

    2013-01-01

    Objective: To identify causative genes for centronuclear myopathies (CNM), a heterogeneous group of rare inherited muscle disorders that often present in infancy or early life with weakness and hypotonia, using next-generation sequencing of whole exomes and genomes. Methods: Whole-exome or -genome sequencing was performed in a cohort of 29 unrelated patients with clinicopathologic diagnoses of CNM or related myopathy depleted for cases with mutations of MTM1, DNM2, and BIN1. Immunofluorescence analyses on muscle biopsies, splicing assays, and gel electrophoresis of patient muscle proteins were performed to determine the molecular consequences of mutations of interest. Results: Autosomal recessive compound heterozygous truncating mutations of the titin gene, TTN, were identified in 5 individuals. Biochemical analyses demonstrated increased titin degradation and truncated titin proteins in patient muscles, establishing the impact of the mutations. Conclusions: Our study identifies truncating TTN mutations as a cause of congenital myopathy that is reported as CNM. Unlike the classic CNM genes that are all involved in excitation-contraction coupling at the triad, TTN encodes the giant sarcomeric protein titin, which forms a myofibrillar backbone for the components of the contractile machinery. This study expands the phenotypic spectrum associated with TTN mutations and indicates that TTN mutation analysis should be considered in cases of possible CNM without mutations in the classic CNM genes. PMID:23975875

  8. Superroot, a recessive mutation in Arabidopsis, confers auxin overproduction.

    PubMed Central

    Boerjan, W; Cervera, M T; Delarue, M; Beeckman, T; Dewitte, W; Bellini, C; Caboche, M; Van Onckelen, H; Van Montagu, M; Inzé, D

    1995-01-01

    We have isolated seven allelic recessive Arabidopsis mutants, designated superroot (sur1-1 to sur1-7), displaying several abnormalities reminiscent of auxin effects. These characteristics include small and epinastic cotyledons, an elongated hypocotyl in which the connection between the stele and cortical and epidermal cells disintegrates, the development of excess adventitious and lateral roots, a reduced number of leaves, and the absence of an inflorescence. When germinated in the dark, sur1 mutants did not develop the apical hook characteristic of etiolated seedlings. We were able to phenocopy the Sur1- phenotype by supplying auxin to wild-type seedlings, to propagate sur1 explants on phytohormone-deficient medium, and to regenerate shoots from these explants by the addition of cytokinins alone to the culture medium. Analysis by gas chromatography coupled to mass spectrometry indicated increased levels of both free and conjugated indole-3-acetic acid. sur1 was crossed to the mutant axr2 and the altered-auxin response mutant ctr1. The phenotype of both double mutants was additive. The sur1 gene was mapped on chromosome 2 at 0.5 centimorgans from the gene encoding phytochrome B. PMID:8589625

  9. Evidence for genetic homogeneity in autosomal recessive generalised myotonia (Becker).

    PubMed Central

    Koch, M C; Ricker, K; Otto, M; Wolf, F; Zoll, B; Lorenz, C; Steinmeyer, K; Jentsch, T J

    1993-01-01

    Generalised myotonia Becker (GM) is an autosomal recessively inherited muscle disorder. Affected subjects exhibit myotonic muscle stiffness in all skeletal muscles with marked hypertrophy in the legs. A transient muscle weakness is particularly pronounced in the arms and hands and is a typical symptom of the disorder. Recently, we showed complete linkage of the disorder GM to the gene (CLCN1) coding for the skeletal muscle chloride channel CLC-1 and the TCRB gene on chromosome 7 in German families. In the study presented here we performed linkage analysis on 14 new GM families. The GM locus was again completely linked to both the CLCN1 and the TCRB gene in all families with a combined lod score of Z = 9.26 at a recombination fraction of theta = 0.00. This confirms our previous data and supports the hypothesis that GM is a genetically homogeneous disorder. The previously detected T to G missense mutation is found on 15% of the 66 GM chromosomes counted so far. PMID:8301644

  10. Assessing resistance types and levels to epidemic diseases from the analysis of disease progress curves: Principles and application to potato late blight

    Microsoft Academic Search

    D. Andrivon; R. Pellé; D. Ellissèche

    2006-01-01

    Both race-specific (RS) and race-non-specific (RNS) resistances exist in potato against the late blight pathogenPhytophthora infestans. Because these resistance types do not have the same epidemiological effects, their presence, alone or combined, in potato\\u000a genotypes can be deduced from the analysis of disease progress curves from field experiments, a type of data commonly available\\u000a to potato breeders, and their comparison

  11. Effect of recess dimensions on performance of the needle-type dissolved oxygen microelectrode sensor

    Microsoft Academic Search

    Tae-Sun Lim; Jin-Hwan Lee; Ian Papautsky

    2009-01-01

    In this work, needle-type recessed dissolved oxygen (DO) microelectrode sensors with different recess dimensions were fabricated and characterized to investigate the relationship between recess dimensions and sensor performance. The square-ring type cathode geometry inside the recess was formed by wet etching, with the recess length ranging from ?35 to ?247?m and the average length to hydraulic diameter (Lave\\/Dh) ratio ranging

  12. Synthetic light-curve analysis of the very short period binaries TY Bootis, AD Cancri, and V523 Cassiopeiae

    SciTech Connect

    Samec, R.G.; Van Hamme, W.; Bookmyer, B.B. (Butler Univ., Indianapolis, IN (USA) Clemson Univ., SC (USA) South Carolina Univ., Conway (USA) Florida International Univ., Miami (USA))

    1989-12-01

    New photometric observations of TY Boo, AD Cnc, and V523 Cas are subjected to synthetic light-curve analyses using the Wilson-Devinney code. Solutions for each of the systems, and the several competing theories of contact binary structure are discussed in light of the results. Both AD Cnc and V523 Cas are modeled with subluminous regions, and the resulting starspot parameters are reported. A simultaneous solution of the B, V light curves and the radial-velocity curves of V523 Cas is presented. Spectroscopic and photometric mass ratios were found to be discordant for both TY Boo and V523 Cas. However, recent spectroscopic work by Groissman seems to remove the discordancy for TY Boo. Absolute parameters are derived for V523 Cas. 43 refs.

  13. Detector response and intensity cross-contribution as contributing factors to the observed non-linear calibration curves in mass spectrometric analysis.

    PubMed

    Sie, Meng-Jie; Chen, Bud-Gen; Chang, Chiung Dan; Lin, Chia-Han; Liu, Ray H

    2011-01-21

    It is a common knowledge that detector fatigue causes a calibration curve to deviate from the preferred linear relationship at the higher concentration end. With the adaptation of an isotopically labeled analog of the analyte as the internal standard (IS), cross-contribution (CC) of the intensities monitored for the ions designating the analyte and the IS can also result in a non-linear relationship at both ends. A novel approach developed to assess 'the extent and the effect of [CC]… in quantitative GC-MS analysis' can be extended (a) to examine whether a specific set of CC values is accurate; and (b) to differentiate whether the observed non-linear calibration curve is caused by detector fatigue or the CC phenomenon. Data derived from the exemplar secobarbital (SB)/SB-d(5) system (as di-butyl-derivatives) are used to illustrate this novel approach. Comparing the non-linear nature of calibration data that are empirically observed to that derived from theoretical calculation (with the incorporation of adjustment resulting from the ion CC phenomenon), supports the conclusions that (a) both CC and detector fatigue contribute significantly to the observed non-linear nature of the calibration curve based on ion-pair m/z 207/212; and (b) detector fatigue is the dominating contributor when the calibration curve is based on ion-pair m/z 263/268. PMID:21049098

  14. Identification of CHIP as a Novel Causative Gene for Autosomal Recessive Cerebellar Ataxia

    PubMed Central

    Shi, Yuting; Wang, Junling; Li, Jia-Da; Ren, Haigang; Guan, Wenjuan; He, Miao; Yan, Weiqian; Zhou, Ying; Hu, Zhengmao; Zhang, Jianguo; Xiao, Jingjing; Su, Zheng; Dai, Meizhi; Wang, Jun; Jiang, Hong; Guo, Jifeng; Zhou, Yafang; Zhang, Fufeng; Li, Nan; Du, Juan; Xu, Qian; Hu, Yacen; Pan, Qian; Shen, Lu; Wang, Guanghui; Xia, Kun; Zhang, Zhuohua; Tang, Beisha

    2013-01-01

    Autosomal recessive cerebellar ataxias are a group of neurodegenerative disorders that are characterized by complex clinical and genetic heterogeneity. Although more than 20 disease-causing genes have been identified, many patients are still currently without a molecular diagnosis. In a two-generation autosomal recessive cerebellar ataxia family, we mapped a linkage to a minimal candidate region on chromosome 16p13.3 flanked by single-nucleotide polymorphism markers rs11248850 and rs1218762. By combining the defined linkage region with the whole-exome sequencing results, we identified a homozygous mutation (c.493CT) in CHIP (NM_005861) in this family. Using Sanger sequencing, we also identified two compound heterozygous mutations (c.389AT/c.441GT; c.621C>G/c.707GC) in CHIP gene in two additional kindreds. These mutations co-segregated exactly with the disease in these families and were not observed in 500 control subjects with matched ancestry. CHIP colocalized with NR2A, a subunit of the N-methyl-D-aspartate receptor, in the cerebellum, pons, medulla oblongata, hippocampus and cerebral cortex. Wild-type, but not disease-associated mutant CHIPs promoted the degradation of NR2A, which may underlie the pathogenesis of ataxia. In conclusion, using a combination of whole-exome sequencing and linkage analysis, we identified CHIP, encoding a U-box containing ubiquitin E3 ligase, as a novel causative gene for autosomal recessive cerebellar ataxia. PMID:24312598

  15. Complete association between a retroviral insertion in the tyrosinase gene and the recessive white mutation in chickens

    PubMed Central

    Chang, Chung-Ming; Coville, Jean-Luc; Coquerelle, Gérard; Gourichon, David; Oulmouden, Ahmad; Tixier-Boichard, Michèle

    2006-01-01

    Background In chickens, three mutant alleles have been reported at the C locus, including the albino mutation, and the recessive white mutation, which is characterized by white plumage and pigmented eyes. The albino mutation was found to be a 6 bp deletion in the tyrosinase (TYR) gene. The present work describes an approach to identify the structural rearrangement in the TYR gene associated with the recessive white mutation. Results Molecular analysis of the chicken TYR gene has revealed a major structural difference (Restriction Fragment Length Polymorphism, RFLP) in the genomic DNA of the recessive white chicken. A major size difference of 7.7 kb was found in intron 4 of the TYR gene by long-range PCR. Molecular cloning and sequencing results showed the insertion of a complete avian retroviral sequence of the Avian Leukosis Virus (ALV) family. Several aberrant transcripts of the tyrosinase gene were found in 10 week old recessive white chickens but not in the homozygous wild type colored chicken. We established a rapid genotyping diagnostic test based on the discovery of this retroviral insertion. It shows that all homozygous carriers of this insertion had a white plumage in various chicken strains. Furthermore, it was possible to distinguish heterozygous carriers from homozygous normal chickens in a segregating line. Conclusion In this study, we conclude that the insertion of a complete avian retroviral sequence in intron 4 of the tyrosinase gene is diagnostic of the recessive white mutation in chickens. This insertion causes aberrant transcripts lacking exon 5, and we propose that this insertion is the causal mutation for the recessive white allele in the chicken. PMID:16457736

  16. Evaluation of the Capacity of PCR and High-Resolution Melt Curve Analysis for Identification of Mixed Infection with Mycoplasma gallisepticum Strains.

    PubMed

    Ghorashi, Seyed A; Kanci, Anna; Noormohammadi, Amir H

    2015-01-01

    Pathogenicity and presentation of Mycoplasma gallisepticum (MG) infection may differ from one strain to another and this may have implications on control measures. Infection of individual birds with more than one MG strain has been reported. A PCR followed by high resolution melt (HRM) curve analysis has been developed in our laboratory and routinely used for detection and differentiation of MG strains. However the potential of this test for identification of MG strains in a mixed specimen has not been evaluated. In the present study, the capability of PCR-HRM curve analysis technique, targeting vlhA and pvpA genes was assessed for identification of individual MG strains in a mixed population. Different DNA ratios of two MG strains from 1 to 10-4 ng were tested with some generated conventional and normalized curves distinct from those of individual strains alone. Using genotype confidence percentages (GCP) generated from HRM curve analysis, it was found that vlhA PCR-HRM was more consistent than pvpA PCR-HRM for the detection of MG ts-11 vaccine strain mixed with any of the MG strains 6/85, F, S6 or a field isolate. The potential of vlhA PCR-HRM to detect mixed MG strains in a specimen was found to be primarily dependent on quantity and proportion of the target DNAs in the mixture. This is the first study examining the capacity of PCR-HRM technique for identification of individual MG strains in a mixed strain population. PMID:25970590

  17. Growth curve analysis of placental and fetal growth influenced by adjacent fetal sex status under crowded uterine conditions in pigs

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Intrauterine position and sex of adjacent fetuses in litter bearing species have been implicated in physiological and behavioral differences in males and females. Our objective was to establish growth curves for fetal and placental weight gain as influenced by sex status of flanking fetuses under cr...

  18. The WEBT BL Lacertae Campaign 2001 and its extension. Optical light curves and colour analysis 1994-2002

    Microsoft Academic Search

    M. Villata; C. M. Raiteri; O. M. Kurtanidze; M. G. Nikolashvili; M. A. Ibrahimov; I. E. Papadakis; G. Tosti; F. Hroch; L. O. Takalo; A. Sillanpää; V. A. Hagen-Thorn; V. M. Larionov; R. D. Schwartz; J. Basler; L. F. Brown; T. J. Balonek; E. Benítez; A. Ramírez; A. C. Sadun; P. Boltwood; M. T. Carini; D. Barnaby; J. M. Coloma; J. A. Ros; B. Z. Dai; G. Z. Xie; J. R. Mattox; D. Rodriguez; I. M. Asfandiyarov; A. Atkerson; J. L. Beem; S. D. Bloom; S. M. Chanturiya; S. Ciprini; S. Crapanzano; J. A. de Diego; N. V. Efimova; D. Gardiol; J. C. Guerra; B. B. Kahharov; B. Z. Kapanadze; H. Karttunen; T. Kato; G. N. Kimeridze; N. A. Kudryavtseva; M. Lainela; L. Lanteri; E. G. Larionova; M. Maesano; N. Marchili; G. Massone; T. Monroe; F. Montagni; R. Nesci; K. Nilsson; J. C. Noble; G. Nucciarelli; L. Ostorero; J. Papamastorakis; M. Pasanen; C. S. Peters; T. Pursimo; P. Reig; W. Ryle; S. Sclavi; L. A. Sigua; M. Uemura; W. Wills

    2004-01-01

    BL Lacertae has been the target of four observing campaigns by the Whole Earth Blazar Telescope (WEBT) collaboration. In this paper we present UBVRI light curves obtained by the WEBT from 1994 to 2002, including the last, extended BL Lac 2001 campaign. A total of about 7500 optical observations performed by 31 telescopes from Japan to Mexico have been collected,

  19. Computational Analysis of Flow in a Curved Tube Model of the Coronary Arteries: Effects of Time-varying Curvature

    Microsoft Academic Search

    Aland Santamarina; Erlend Weydahl

    1998-01-01

    The flow through a curved tube whose radius of curvature varies with time was studied in order to better understand flow patterns in coronary arteries. A computational flow model was constructed using commercially available software. The artery model featured a uniform circular cross section, and the curvature was assumed to be constant along the tube, and in one plane. The

  20. A Unified Latent Curve, Latent State-Trait Analysis of the Developmental Trajectories and Correlates of Positive Orientation

    Microsoft Academic Search

    Guido Alessandri; Gian Vittorio Caprara; John Tisak

    2012-01-01

    Literature documents that the judgments people hold about themselves, their life, and their future are important ingredients of their psychological functioning and well-being and are commonly related to each other. In this article, results from a longitudinal study (N = 298, 45% males) are presented. Using an integrative Latent Curve, Latent State-Trait Model (Tisak & Tisak, 2000), results corroborated (a)

  1. A numerical analysis of heat and fluid flow with a deformable curved free surface in a laser melting process

    Microsoft Academic Search

    Young-Deuk Kim; Woo-Seung Kim

    2008-01-01

    In this study, a numerical investigation was performed to examine the effects of curved surface shapes, laser power intensity, and the thermophysical properties of a material such as Reynolds and Capillary numbers on the shape, size, and surface topography of the melt pool. This investigation was completed via two-dimensional axisymmetric thermocapillary convection analyses during laser melting processes with deformable free

  2. Statistical methods for pavement performance curve building, historical analysis, data sampling and storage: Appendix D. Final report

    SciTech Connect

    NONE

    1998-08-01

    The technical memorandum is intended to discuss the detailed procedure required for carrying out the statistical analyses of historical pavement condition data for building pavement performance curves. This chapter assumes the availability of the historical data in a spreadsheet format (Microsoft{trademark} Excel) that has been retrieved from the master (pavement management system) database.

  3. Effect of modal overlap factor on the ray tracing analysis of the curved beam structure: A computational study

    Microsoft Academic Search

    Cheol-Ho Jeong; Jeong-Guon Ih

    2003-01-01

    Ray tracing method (RTM) of the geometrical acoustics area is recently known to be useful for the evaluation of spatial distribution of energy density and power flow of vibrating structures at high frequencies. In this study, the spatial distribution of vibrational energy and power flow of curved beam and its connected structures are of interest. Longitudinal, flexural, and torsional waves

  4. Mixed models defined by stochastic differential equations 1 Bayesian analysis of growth curves using mixed models defined by stochastic

    E-print Network

    Samson, Adeline

    of repeated measurements of a continuous growth process over time in a population of individuals. These data curve data consist of repeated measurements of a growth process over time among a population are classically analyzed by nonlinear mixed models. However, the standard growth functions used in this context

  5. Determination of magnetic properties of rocks by analysis of demagnetization curves: Hematite-ilmenite bearing rocks from SW Sweden

    Microsoft Academic Search

    Erik Eneroth; Leif Johansson

    2008-01-01

    Granulites from the high-grade Sveconorwegian (corresponding to Grenvillian) gneiss terrane of SW Sweden were investigated in order to relate magnetic properties to the granulite facies mineralogy and the amphibolite facies retrograde mineralogy. We used standard paleomagnetic techniques, susceptibility measurements, electron and optical microscopy, and a new way to analyze demagnetization curves based on vector difference sums. The new technique allowed

  6. NMR for direct determination of K(m) and V(max) of enzyme reactions based on the Lambert W function-analysis of progress curves.

    PubMed

    Exnowitz, Franziska; Meyer, Bernd; Hackl, Thomas

    2012-03-01

    (1)H NMR spectroscopy was used to follow the cleavage of sucrose by invertase. The parameters of the enzyme's kinetics, K(m) and V(max), were directly determined from progress curves at only one concentration of the substrate. For comparison with the classical Michaelis-Menten analysis, the reaction progress was also monitored at various initial concentrations of 3.5 to 41.8mM. Using the Lambert W function the parameters K(m) and V(max) were fitted to obtain the experimental progress curve and resulted in K(m)=28mM and V(max)=13?M/s. The result is almost identical to an initial rate analysis that, however, costs much more time and experimental effort. The effect of product inhibition was also investigated. Furthermore, we analyzed a much more complex reaction, the conversion of farnesyl diphosphate into (+)-germacrene D by the enzyme germacrene D synthase, yielding K(m)=379?M and k(cat)=0.04s(-1). The reaction involves an amphiphilic substrate forming micelles and a water insoluble product; using proper controls, the conversion can well be analyzed by the progress curve approach using the Lambert W function. PMID:22079737

  7. A model of light-curve synthesizing for dwarf novae and the analysis of the OY CAR observations by application of the inverse-problem method

    NASA Astrophysics Data System (ADS)

    Djuraševi?, Gojko

    1996-09-01

    The paper contains a model synthesizing the light curves of novae and novae-like stars, as well as of active close binaries (CB) in the phase of an intensive matter exchange between the components with accretion onto a white dwarf. The model considers the radial and azimuthal temperature distributions in the disk enabling a successful interpretation of asymmetrically deformed light curves characteristic for these systems. The analysis of the observed light curves is performed by using the inverse-problem method (Djuraševi?, 1992b) adapted to this model. In the particular case the parameters for the dwarf-novaOY Car are estimated on the basis of the U and B observations (Woodet al., 1989). The synthetic light curves obtained through the inverse-problem solving, as a whole, fit the observations well which indicates that it is possible to estimate the system parameters on the basis of the model proposed here. The obtained results indicate a complex hot-spot structure approximated in the model with two components—a central part and a surrounding spot larger in size. The central hot-spot part (temperature about 10000 K is surrounded asymmetrically by the larger spot lower in temperature (about 7000 K). The radiation of the central hot spot is ‘beamed’ forward by about 20°. The angular size of the hot-spot central part is about 5°, the centre longitude is 322°, whereas for the surrounding spot the size is about 33° and the longitude of the centre about 300°. For the mass ratio of the componentsq=0.102 one finds for the orbit inclination about 83°.8. The analysis shows that the disk radius is about 51% of the corresponding Roche lobe radius. Based on the U and B light curves the quiescent disk-edge temperature is estimated to about 5500 K (U), i.e. 4400 K (B). The disk-radial-temperature profile is much flatter than in the steady-state-approximation case. Beginning from the edge towards the disk centre the temperature slowly increases attaining about 7200 K (U), i.e. 5700 K (B) near the white dwarf. The differences in the solutions for the U and B light curves can be due to deviations in the disk radiation from the black-body approximation assumed in the present model. Expressed in the units of the distance between the component centres [D=1] the disk size is estimated to about 0.304 [D=1], its thickness to 0.014 [D=1], and the white-dwarf radius to about 0.02 [D=1]. The white-dwarf temperature is about 15000 K. The obtained results are in a relatively good agreement with the system parameters estimated earlier (Woodet al., 1989). This indicates that the proposed model of the system and the corresponding inverse-problem method briefly presented here are fully applicable to the analysis of active CB light curves in this evolutionary phase. Though the model given here includes a number of approximations, it enables an independent procedure in the observational-material analysis based on the light-curve synthesis and on the application of the inverse-problem method. Results obtained by applying such an independent method can also serve as a reasonable way in testing the solutions obtained by utilising the earlier approaches.

  8. The Great Recession and the risk for child maltreatment.

    PubMed

    Brooks-Gunn, Jeanne; Schneider, William; Waldfogel, Jane

    2013-10-01

    This study draws on the Fragile Families and Child Wellbeing Study (N=2,032), a birth cohort study of families with children from 20 U.S. cities. Interviews occurred between August 2007, and February 2010, when the children were approximately 9 years old. Macro-economic indicators of the Great Recession such as the Consumer Sentiment Index and unemployment and home foreclosure rates were matched to the data to estimate the links between different measures of the Great Recession and high frequency maternal spanking. We find that the large decline in consumer confidence during the Great Recession, as measured by the Consumer Sentiment Index, was associated with worse parenting behavior. In particular, lower levels of consumer confidence were associated with increased levels of high frequency spanking, a parenting behavior that is associated with greater likelihood of being contacted by child protective services. PMID:24045057

  9. The Great Recession and the Risk for Child Maltreatment

    PubMed Central

    Brooks-Gunn, Jeanne; Schneider, William; Waldfogel, Jane

    2013-01-01

    This study draws on the Fragile Families and Child Wellbeing Study (N = 2,032), a birth cohort study of families with children from 20 U.S. cities. Interviews occurred between August 2007, and February 2010, when the children were approximately 9 years old. Macro-economic indicators of the Great Recession such as the Consumer Sentiment Index and unemployment and home foreclosure rates were matched to the data to estimate the links between different measures of the Great Recession and high frequency maternal spanking. We find that the large decline in consumer confidence during the Great Recession, as measured by the Consumer Sentiment Index, was associated with worse parenting behavior. In particular, lower levels of consumer confidence were associated with increased levels of high frequency spanking, a parenting behavior that is associated with greater likelihood of being contacted by child protective services. PMID:24045057

  10. Analysis of MOST light curves of five young stars in Taurus-Auriga and Lupus~3 Star Forming Regions

    E-print Network

    Siwak, Michal; Matthews, Jaymie M; Kuschnig, Rainer; Guenther, David B; Moffat, Anthony F J; Sasselov, Dimitar; Weiss, Werner W

    2011-01-01

    Continuous photometric observations of five young stars obtained by the MOST satellite in 2009 and 2010 in the Taurus and Lupus star formation regions are presented. Using light curve modelling under the assumption of internal invariability of spots, we obtained small values of the solar-type differential-rotation parameter (k=0.0005-0.009) for three spotted weak-line T Tau stars, V410 Tau, V987 Tau and Lupus 3-14; for another spotted WTTS, Lupus 3-48, the data are consistent with a rigidly rotating surface (k=0). Three flares of similar rise (4 min 30 sec) and decay (1 h 45 min) times were detected in the light curve of Lupus 3-14. The brightness of the classical T Tau star RY Tau continuously decreased over 3 weeks of its observations with a variable modulation not showing any obvious periodic signal.

  11. Analysis of the Effect of Light and Temperature on the Fluence Response Curves for Germination of Rumex obtusifolius

    PubMed Central

    Takaki, Massanori; Heeringa, Gerda H.; Cone, John W.; Kendrick, Richard E.

    1985-01-01

    Both red light (10 minutes) and 35°C treatment (60 minutes) stimulate the germination of seeds of Rumex obtusifolius otherwise maintained in darkness at 25°C. Fluence response curves were determined for the effect of red light to stimulate germination of seeds with and without 35°C treatment. The endogenous far-red absorbing form (Pfr) level in the seeds was determined using short saturating fluences of wavelengths of light which maintain different proportions of phytochrome as Pfr at equilibrium. In the seed batches investigated, the endogenous Pfr level was found to be 4% or less of the total phytochrome. High dark germination after 35°C treatment does not result from an increase in sensitivity of the whole population to Pfr. Calculated fluence response curves for germination which best fit the experimental data suggest that seeds germinate in darkness after 35°C treatment because of a nonphytochrome-related process (overriding factor). PMID:16664125

  12. Synthetic light-curve analysis of the very short period binaries TY Bootis, AD Cancri, and V523 Cassiopeiae

    Microsoft Academic Search

    Ronald G. Samec; Walter van Hamme; Beverly B. Bookmyer

    1989-01-01

    New photometric observations of TY Boo, AD Cnc, and V523 Cas are subjected to synthetic light-curve analyses using the Wilson-Devinney code. Solutions for each of the systems, and the several competing theories of contact binary structure are discussed in light of the results. Both AD Cnc and V523 Cas are modeled with subluminous regions, and the resulting starspot parameters are

  13. Television Viewing and Adolescents’ Judgment of Sexual Request Scripts: A Latent Growth Curve Analysis in Early and Middle Adolescence

    Microsoft Academic Search

    Steven Eggermont

    2006-01-01

    A longitudinal study was conducted to explore the relationship between television viewing and beliefs about expressing sexual\\u000a desire in dating situations. In three consecutive years, a panel of early adolescents (N?=?883) and a panel of middle adolescents (N?=?651) rated the effectiveness of a sexual approach and a romantic approach. Latent growth curve analyses indicate that between\\u000a the ages of 12

  14. THE URANIUM HEXAFLUORIDE-HYDROGEN FLUORIDE FREEZING POINT CURVE AND ITS APPLICATION TO A METHOD OF ANALYSIS

    Microsoft Academic Search

    R. J. Wertz; W. D. Hedge

    1960-01-01

    The freezing point curve for the system uranium hexafluoride--hydrogen ; fluoride was determined over the range 0.0 to 0.6 wt% hydrogen fluoride and is ; represented by the equation wt% HF = 0.0841 DELTA t + 0.1020 DELTA t² -- ; 0.1046 DELTA t³ + 0.0363 DELTA t⁴ where DELTA t is the depression ; of the freezing point of

  15. Developmental changes in group climate in two types of group therapy for binge-eating disorder: A growth curve analysis

    Microsoft Academic Search

    Giorgio A. Tasca; Louise Balfour; Kerri Ritchie; Hany Bissada

    2006-01-01

    The development of group climate across 16 sessions of group psychodynamic–interpersonal psychotherapy (GPIP) and group cognitive–behavioral therapy (GCBT) for 65 female treatment completers with binge-eating disorder (BED) was assessed. Engaged scale growth for GPIP patients varied across sessions and was best represented by a cubic growth curve. This suggested that GPIP progressed in definable phases that reflected a rupture and

  16. Evaluation of hemoglobin performance in the assessment of iron stores in feto-maternal pairs in a high-risk population: receiver operating characteristic curve analysis

    PubMed Central

    Jaime-Pérez, José Carlos; García-Arellano, Gisela; Méndez-Ramírez, Nereida; González-Llano, Óscar; Gómez-Almaguer, David

    2015-01-01

    Objective By applying receiver operating characteristic curve analysis, the objective of this study was to see whether hemoglobin levels reflect body iron stores in a group of pregnant women at term who, by using serum ferritin as the reference test, had a high pre-test probability of having iron deficiency anemia. Likewise, we evaluated the ability of hemoglobin and maternal serum ferritin levels to predict iron deficiency anemia in newborns. Methods Hemoglobin and serum ferritin were measured in 187 pregnant women at term belonging to a group with a high pre-test probability of iron deficiency anemia and their newborns. Women with Hb <11.0 g/dL and newborns with cord Hb <13.0 g/dL were classified as anemic. A serum ferritin <12.0 ?g/L in women and a cord blood serum ferritin <35.0 ?g/L were considered to reflect empty iron stores. Receiver operating characteristic curve analysis was applied to select the cut-off points that better reflected iron stores. Results The Hb cut-off point selected by receiver operating characteristic curve analysis in women was <11.5 g/dL (sensitivity: 60.82, specificity: 53.33%, Youden Index: 0.450). Most of the newborns had normal Hb which precluded this analysis. Maternal Hb <11.0 g/dL was the cut-off point that best reflected iron deficiency anemia in newborns (sensitivity: 55.88%, specificity: 57.24%, Youden Index: 0.217). The best cut-off point of maternal serum ferritin to reflect empty iron stores in newborns was <6.0 ?g/L (sensitivity: 76.47%, specificity: 31.58%, Youden Index: 0.200). Conclusion Hemoglobin concentration performed poorly to detect iron deficiency anemia in women at term with high risk for iron deficiency and their newborns. PMID:26041420

  17. Fourier Descriptors for Plane Closed Curves

    Microsoft Academic Search

    Charles T. Zahn; Ralph Z. Roskies

    1972-01-01

    A method for the analysis and synthesis of closed curves in the plane is developed using the Fourier descriptors FD's of Cosgriff [1]. A curve is represented parametrically as a function of arc length by the accumulated change in direction of the curve since the starting point. This function is expanded in a Fourier series and the coefficients are arranged

  18. A Quarter-Century of Glacier Recession in the Tropical Andes from Landsat: c1987 - c2013

    NASA Astrophysics Data System (ADS)

    Slayback, D. A.; Tucker, C. J.

    2014-12-01

    The glaciers of the tropical Andes constitute 99% of the world's tropical glaciers. They primarily occur in Peru and Bolivia (90%) with smaller glaciers scattered across the peaks in Ecuador, Colombia, and Venezuela. Specific glaciers in the range have been studied in great detail, such as Bolivia's Zongo glacier and Peru's Quelccaya Ice Cap, but few studies of glacier recession across the full range have been published. We previously assessed glacier recession between c1987 and c2006 using manual classification techniques on Landsat imagery. We have now updated that study to the present (2013/2014), and and have incorporated automated techniques using support vector machines. The update to present allows us to examine both the variability in recession rates, and the current state of overall recession. The primary issues in completing this analysis are accounting for snow cover (which can otherwise be easily misidentified as glacier), and developing a robust and semi-automated methodology to process the large number of individual images required. To avoid confusion with transient snow, we analysed 2-3 clear images at each epoch, with minimal visually apparent snow or glacier, and only labelled as glacier those pixels that were classified as glacier in the clear portions of each image. To automate the processing, we used support vector machines, trained with the extensive data we have available from our previous manual classification work.Our previous work indicated an overall recession of approximately 30% (or 700 km2 of glacier area loss) between c1987 and c2006. We will present updated figures from our new analysis, extending to 2013/2014.

  19. 3. VIEW LOOKING EAST AT UPPER GATE RECESS FROM THE ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    3. VIEW LOOKING EAST AT UPPER GATE RECESS FROM THE OHIO RIVER. (NOTE: REMAINS OF TRACKS FROM ROLLING LOCK GATE, PARTIALLY SUBMERGED.) - Ohio Slack Water Dams, Lock & Dam No. 4, East bank of Ohio River at mile point 18.6, along State Route 65, Ambridge, Beaver County, PA

  20. 1. VIEW LOOKING EAST AT LOWER GATE RECESS AND LOWER ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. VIEW LOOKING EAST AT LOWER GATE RECESS AND LOWER GUIDE WALL FROM THE OHIO RIVER. - Ohio Slack Water Dams, Lock & Dam No. 4, East bank of Ohio River at mile point 18.6, along State Route 65, Ambridge, Beaver County, PA

  1. Does it take an economic recession to advance social entrepreneurship?

    Microsoft Academic Search

    Paul van Putten II; Robert D. Green

    More than 4 billion people in the world live on less than $2 per day, and they are not just in developing countries. In recent years, there is a trend of greater interest of entrepreneurs in social causes. However, people have experienced an economic recession since December 2007 that is expected to last into 2010, the longest since the Great

  2. Rural Studies Program Hunger in Oregon Since the Great Recession

    E-print Network

    Escher, Christine

    Rural Studies Program Hunger in Oregon Since the Great Recession Snehalatha Gantla and Mark Edwards School of Public Policy and the Rural Studies Program Oregon State University February 2014 Rural Studies,018 n=132,018 Geography Oregon's rural and urban hunger rates appear to be about the same right after

  3. Evidence for the Recessive Nature of Cellular Immortality

    Microsoft Academic Search

    O. M. Pereira-Smith; J. R. Smith

    1983-01-01

    Fusion of immortal cell lines with normal human fibroblasts or certain other immortal cell lines yields hybrids having limited division potential. Cellular immortality was found to be a recessive phenotype in hybrids. It was also found that at least two separate events in the normal cell genome can result in immortality. In fusions involving certain immortal parent cells, these events

  4. Reporting of haplotypes with recessive effects on fertility

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Genomic discovery of five haplotypes with recessive effects on fertility requires new automated tracking methods for QTL causing embryo loss in breeding programs. Most of the losses are early in gestation. Approximate locations of the five QTL were refined using crossovers detected within the pedigr...

  5. Evidence for genetic homogeneity in autosomal recessive generalised myotonia (Becker)

    Microsoft Academic Search

    M C Koch; K Ricker; M Otto; F Wolf; B Zoll; C Lorenz; K Steinmeyer; T J Jentsch

    1993-01-01

    Generalised myotonia Becker (GM) is an autosomal recessively inherited muscle disorder. Affected subjects exhibit myotonic muscle stiffness in all skeletal muscles with marked hypertrophy in the legs. A transient muscle weakness is particularly pronounced in the arms and hands and is a typical symptom of the disorder. Recently, we showed complete linkage of the disorder GM to the gene (CLCN1)

  6. 11. VIEW WEST, RECESS AREA WITH PORTION OF MITER SILL ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    11. VIEW WEST, RECESS AREA WITH PORTION OF MITER SILL (Numbers painted on stones for reconstruction purposes) - Bald Eagle Cross-Cut Canal Lock, North of Water Street along West Branch of Susquehanna River South bank, 500 feet East of Jay Street Bridge, Lock Haven, Clinton County, PA

  7. Applications to One Business School Skyrocketed Despite Recession

    ERIC Educational Resources Information Center

    Tao, Sharon

    2010-01-01

    In the past two years, the global financial crisis has wreaked havoc on businesses in America and abroad. But the gloom and doom seems to have had the opposite effect on business schools. The reason is that a recession often signals the perfect time for proactive students to sharpen their skill sets, shift their career goals (whether toward a…

  8. Intrinsically Motivated, Free-Time Physical Activity: Considerations for Recess

    ERIC Educational Resources Information Center

    Stellino, Megan Babkes; Sinclair, Christina D.

    2008-01-01

    The current childhood obesity rates raise concern about youths' health and the role that a sedentary lifestyle plays in this growing trend. Focusing on how children choose to spend their free time is one approach that may yield ideas for reducing childhood obesity. Recess is a regularly occurring "free time" period in elementary schools. It is,…

  9. College Costs, Prices and the Great Recession. Lumina Issue Papers

    ERIC Educational Resources Information Center

    Johnson, Nate

    2014-01-01

    As states and families begin to recover from the effects of the Great Recession, some of the urgency about college affordability may start to ease. The most recent "Trends in College Pricing" report shows tuition rising more slowly than in recent years (Baum and Ma 2013). Growth in Pell grant applications is also expected to slow as…

  10. 13. DETAIL VIEW, OF TAINTER GATE PIER, SHOWING RECESSES FOR ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    13. DETAIL VIEW, OF TAINTER GATE PIER, SHOWING RECESSES FOR EMERGENCY BULKHEADS AND DOGGING DEVICES, LOOKING SOUTHEAST (DOWN FACE). UPSTREAM FACE OF TAINTER GATE IS VISIBLE IN UPPER RIGHT CORNER - Upper Mississippi River 9-Foot Channel Project, Lock & Dam 26R, Alton, Madison County, IL

  11. Spectrum of ABCR gene mutations in autosomal recessive macular dystrophies

    Microsoft Academic Search

    Jean-Michel Rozet; Sylvie Gerber; Eric Souied; Isabelle Perrault; Sophie Châtelin; Imad Ghazi; Corinne Leowski; Jean-Louis Dufier; Arnold Munnich; Josseline Kaplan; J-M Rozet

    1998-01-01

    Stargardt disease (STGD) and late-onset fundus flavimaculatus (FFM) are autosomal recessive conditions leading to macular degenerations in childhood and adulthood, respectively. Recently, mutations of the photoreceptor cell-specific ATP binding transporter gene (ABCR) have been reported in Stargardt disease. Here, we report on the screening of the whole coding sequence of the ABCR gene in 40 unrelated STGD and 15 FFM

  12. 7. Detail of east wall on ground level showing recessed ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    7. Detail of east wall on ground level showing recessed doors and elliptical louvered transoms. - New York, New Haven, & Hartford Railroad, Shell Interlocking Tower, New Haven Milepost 16, approximately 100 feel east of New Rochelle Junction, New Rochelle, Westchester County, NY

  13. The Post-Recession Employment Situation: A Comparative Perspective

    ERIC Educational Resources Information Center

    Couch, Kenneth A.

    2012-01-01

    Slow economic growth since the end of the U.S. recession in June of 2009 has not yet translated into increases in employment large enough to meaningfully reduce the rate of unemployment. Because expansionary macroeconomic policy has been pursued on both the fiscal and monetary fronts, it appears at first glance that the hands of government at this…

  14. Instructions for Glacier Recession Lesson Objective: Students will learn

    E-print Network

    Instructions for Glacier Recession Lesson Objective: Students will learn: - about the connection post-discussion) The movie or some other type of lesson relating glaciers to climate change should amount of ice and multiply by 100. If using Option 3 (GIS lesson on computers): #12;

  15. Hard Times. The Recession Imperils School Reforms and Teachers' Jobs.

    ERIC Educational Resources Information Center

    Harp, Lonnie

    1991-01-01

    The current recession in the United States imperils teachers' jobs and school reform. States are prioritizing increased spending in such areas as health care and transportation rather than educational improvement. The article discusses specific educational hard times in several states and counties. (SM)

  16. EDS IV (acrogeria): new autosomal dominant and recessive types.

    PubMed

    Pope, F M; Nicholls, A C; Jones, P M; Wells, R S; Lawrence, D

    1980-03-01

    Evidence is presented that type IV of the Ehlers-Danlos syndrome (EDS IV) is genetically variable. A benign autosomal dominant form and two autosomal recessive variants are described with clinical and biochemical features that are distinct from classical acrogeria. PMID:7230200

  17. Recess, Physical Education, and Elementary School Student Outcomes

    ERIC Educational Resources Information Center

    Dills, Angela K.; Morgan, Hillary N.; Rotthoff, Kurt W.

    2011-01-01

    Today's children experience a decreased amount of time at recess and fewer physical education (PE) classes throughout the school day. Breaks for physical activity limit class time for academics, potentially reducing learning. However, breaks may improve alertness and achievement. Using the Early Childhood Longitudinal Survey Kindergarten Class of…

  18. Permanent prostate brachytherapy: Dosimetric results and analysis of a learning curve with a dynamic dose-feedback technique

    SciTech Connect

    Acher, Peter [Department of Urology, Guy's and St. Thomas' NHS Foundation Trust, London (United Kingdom)]. E-mail: peter.acher@gstt.nhs.uk; Popert, Rick [Department of Urology, Guy's and St. Thomas' NHS Foundation Trust, London (United Kingdom); Nichol, Janette [Department of Urology, Guy's Hospital, London (United Kingdom); Potters, Louis [New York Prostate Institute, South Nassau Communities Hospital, Oceanside, NY (United States); Morris, Stephen [Department of Clinical Oncology, Guy's and St. Thomas' NHS Foundation Trust, London (United Kingdom); Beaney, Ronald [Department of Clinical Oncology, Guy's and St. Thomas' NHS Foundation Trust, London (United Kingdom)

    2006-07-01

    Purpose: A permanent prostate brachytherapy (PPB) program utilizing intraoperative inverse-planned dynamic dose-feedback was initiated without prior firsthand experience of alternative techniques. The purpose of this study is to assess the dosimetric learning curve associated with this approach. Methods and Materials: A total of 77 patients underwent PPB implants as monotherapy for localized prostate cancer to a prescription dose of 145 Gy with loose 125I seeds between December 2003 and June 2004. Intraoperative and postoperative dosimetric values, total implanted radioactivity, and operating room (OR) times were compared by sequential case number for all cases. Results: The median intraoperative dosimetric values were: D90 (the minimum dose to 90% of the prostate) = 170 Gy (range, 135-203 Gy), V100 (the volume of the prostate that receives 100% of the prescription dose) = 96% (range, 86-100), V150 = 66% (range, 34-86). Median postoperative dosimetric values were as follows: D90 = 168 Gy (range, 132-197 Gy), V100 = 95% (range, 86-99), V150 = 74% (range, 51-84). Median implanted activity was 0.79 mCi per cubic centimeter of prostate (range, 0.541-1.13). There was no significant correlation by case number on any postoperative dosimetric parameter studied. Door-to-door OR time was reduced from median 138 to 97.5 min per case at the end of the series with a correlation coefficient of -0.76 for the initial 28 cases. Conclusion: Satisfactory dosimetric parameters can be achieved from the outset without a learning curve effect in an appropriately trained environment. The learning curve for dynamic dose-feedback PPB in a clinic naive to other techniques is apparent in terms of OR time.

  19. Direct Analysis of JV-Curves Applied to an Outdoor-Degrading CdTe Module (Presentation)

    SciTech Connect

    Jordan, D; Kurtz, S.; Ulbrich, C.; Gerber, A.; Rau, U.

    2014-03-01

    We present the application of a phenomenological four parameter equation to fit and analyze regularly measured current density-voltage JV curves of a CdTe module during 2.5 years of outdoor operation. The parameters are physically meaningful, i.e. the short circuit current density Jsc, open circuit voltage Voc and differential resistances Rsc, and Roc. For the chosen module, the fill factor FF degradation overweighs the degradation of Jsc and Voc. Interestingly, with outdoor exposure, not only the conductance at short circuit, Gsc, increases but also the Gsc(Jsc)-dependence. This is well explained with an increase in voltage dependent charge carrier collection in CdTe.

  20. Comparison of environmental TLD (thermoluminescent dosimeter) results obtained using glow curve deconvolution and region of interest analysis

    SciTech Connect

    Not Available

    1987-01-01

    We tested a Harshaw Model 4000 TLD Reader in the Sandia Environmental TLD Program. An extra set of LiF TLD-700 chips were prepared for each field location and calibration level. At the end of quarter one, half of the TLDs were read on the Model 4000 and the other half were read on our standard Harshaw Model 2000. This presentation compares the results of the two systems. The Model 4000 results are reported for two regions of interest and for background subtraction using Harshaw Glow Curve Deconvolution Software.

  1. Effect of recess pressure ratio on the characteristics of a hybrid bearing

    E-print Network

    Ingram, Michael William

    1994-01-01

    for a variation in the design parameters of radial clearance, recess pressure ratio, and recess to land area ratio while holding the other parameters constant. This thesis presents the theoretical and experimental characteristics...

  2. An Exploratory Analysis of Personality, Attitudes, and Study Skills on the Learning Curve within a Team-based Learning Environment

    PubMed Central

    Henry, Teague; Campbell, Ashley

    2015-01-01

    Objective. To examine factors that determine the interindividual variability of learning within a team-based learning environment. Methods. Students in a pharmacokinetics course were given 4 interim, low-stakes cumulative assessments throughout the semester and a cumulative final examination. Students’ Myers-Briggs personality type was assessed, as well as their study skills, motivations, and attitudes towards team-learning. A latent curve model (LCM) was applied and various covariates were assessed to improve the regression model. Results. A quadratic LCM was applied for the first 4 assessments to predict final examination performance. None of the covariates examined significantly impacted the regression model fit except metacognitive self-regulation, which explained some of the variability in the rate of learning. There were some correlations between personality type and attitudes towards team learning, with introverts having a lower opinion of team-learning than extroverts. Conclusion. The LCM could readily describe the learning curve. Extroverted and introverted personality types had the same learning performance even though preference for team-learning was lower in introverts. Other personality traits, study skills, or practice did not significantly contribute to the learning variability in this course. PMID:25861101

  3. Comparison of models for describing the lactation curve of latxa sheep and an analysis of factors affecting milk yield.

    PubMed

    Ruiz, R; Oregui, L M; Herrero, M

    2000-11-01

    The objectives of this work were 1) to compare the goodness-of-fit of empirical models of the lactation curve and 2) to analyze the factors affecting the shapes of the lactation curves, the parameters describing them, and the overall milk yield of Latxa dairy sheep. A total of 14,699 records from 2711 ewes, collected during three consecutive years (1995 to 1997) by the milk recording program of the Latxa ewe of the Basque Country (Spain), were used. Six mathematical models and three fitting procedures were compared. The estimation of model parameters by nonlinear fitting procedures was superior to that by linear regression methods. A nonlinear variable decay model fitted the data better than the other models, as judged by lower mean square prediction error, residual sums of squares, and a lack of first-order positive autocorrelation as assessed by the Durbin Watson coefficient. The effects of the flock, flock-year interaction, month of lambing, length of lactation nested within month of lambing, parity, and number of live lambs born had significant effects on the parameters of the model and the total milk yield (P < 0.01). The prediction of milk yield from the selected model was similar to the estimates obtained with the Fleischmann method currently used by the national breeding program for the Latxa breed. PMID:11104292

  4. Radiation Hydrodynamics of SN 1987A. I. Global Analysis of the Light Curve for the First 4 Months

    NASA Astrophysics Data System (ADS)

    Blinnikov, Sergei; Lundqvist, Peter; Bartunov, Oleg; Nomoto, Ken'ichi; Iwamoto, Koichi

    2000-04-01

    The optical/UV light curves of SN 1987A are analyzed with the multienergy group radiation hydrodynamics code STELLA. The calculated monochromatic and bolometric light curves are compared with observations shortly after shock breakout, during the early plateau, through the broad second maximum, and during the earliest phase of the radioactive tail. We have concentrated on a progenitor model calculated by Nomoto & Hashimoto and Saio, Nomoto, & Kato, which assumes that 14 Msolar of the stellar mass is ejected. Using this model, we have updated constraints on the explosion energy and the extent of mixing in the ejecta. In particular, we determine the most likely range of E/M (explosion energy over ejecta mass) and R0 (radius of the progenitor). In general, our best models have energies in the range E=(1.1+/-0.3)x1051 ergs, and the agreement is better than in earlier, flux-limited diffusion calculations for the same explosion energy. Our modeled B and V fluxes compare well with observations, while the flux in U undershoots after ~10 days by a factor of a few, presumably owing to NLTE and line transfer effects. We also compare our results with IUE observations, and a very good quantitative agreement is found for the first days, and for one IUE band (2500-3000 Å) as long as for 3 months. We point out that the V flux estimated by McNaught & Zoltowski should probably be revised to a lower value.

  5. Automatic Classification of X-rated Videos using Obscene Sound Analysis based on a Repeated Curve-like Spectrum Feature

    E-print Network

    Lim, JaeDeok; Han, SeungWan; Lee, ChoelHoon

    2011-01-01

    This paper addresses the automatic classification of X-rated videos by analyzing its obscene sounds. In this paper, obscene sounds refer to audio signals generated from sexual moans and screams during sexual scenes. By analyzing various sound samples, we determined the distinguishable characteristics of obscene sounds and propose a repeated curve-like spectrum feature that represents the characteristics of such sounds. We constructed 6,269 audio clips to evaluate the proposed feature, and separately constructed 1,200 X-rated and general videos for classification. The proposed feature has an F1-score, precision, and recall rate of 96.6%, 98.2%, and 95.2%, respectively, for the original dataset, and 92.6%, 97.6%, and 88.0% for a noisy dataset of 5dB SNR. And, in classifying videos, the feature has more than a 90% F1-score, 97% precision, and an 84% recall rate. From the measured performance, X-rated videos can be classified with only the audio features and the repeated curve-like spectrum feature is suitable to...

  6. Root systems, spectral curves, and analysis of a Chern-Simons matrix model for Seifert fibered spaces

    E-print Network

    Gaëtan Borot; Bertrand Eynard; Alexander Weiße

    2014-07-16

    We study a class of scalar, linear, non-local Riemann-Hilbert problems (RHP) involving finite subgroups of PSL(2,C). We associate to such problems a (maybe infinite) root system and describe the relevance of the orbits of the Weyl group in the construction of its solutions. As an application, we study in detail the large N expansion of SU(N) or SO(N) or Sp(2N) Chern-Simons partition function Z_N(M) of 3-manifolds M that are either rational homology spheres or more generally Seifert fibered spaces. It has a matrix model-like representation, whose spectral curve can be characterized in terms of a RHP as above. When pi_1(M) is finite (i.e. for manifolds M that are quotients of \\mathbb{S}_{3} by a finite isometry group of type ADE), the Weyl group associated to the RHP is finite and the spectral curve is algebraic and can be in principle computed. We then show that the large $N$ expansion of Z_N(M) is computed by the topological recursion. This has consequences for the analyticity properties of SU/SO/Sp perturbative invariants of knots along fibers in $M$.

  7. The 2003 Nov 14 occultation by Titan of TYC 1343-1865-1. II. Analysis of light curves

    E-print Network

    Zalucha, A; Elliot, J L; Thomas-Osip, J; Hammel, H B; Dhillon, V S; Marsh, T R; Taylor, F W; Irwin, P G J

    2007-01-01

    We observed a stellar occultation by Titan on 2003 November 14 from La Palma Observatory using ULTRACAM with three Sloan filters: u', g', and i' (358, 487, and 758 nm, respectively). The occultation probed latitudes 2 degrees S and 1 degrees N during immersion and emersion, respectively. A prominent central flash was present in only the i' filter, indicating wavelength-dependent atmospheric extinction. We inverted the light curves to obtain six lower-limit temperature profiles between 335 and 485 km (0.04 and 0.003 mb) altitude. The i' profiles agreed with the temperature measured by the Huygens Atmospheric Structure Instrument [Fulchignoni, M. et al., 2005. Nature 438, 785-791] above 415 km (0.01 mb). The profiles obtained from different wavelength filters systematically diverge as altitude decreases, which implies significant extinction in the light curves. Applying an extinction model [Elliot, J.L., Young, L.A., 1992. Astron. J. 103, 991-1015] gave the altitudes of line of sight optical depth equal to unit...

  8. Factoring integers with elliptic curves

    Microsoft Academic Search

    H. W. Lenstra

    1987-01-01

    Abstract This paper is devoted to the description and analysis of a new algorithm to factor positive integers. It depends on the use of elliptic curves. The new method is obtained from,Pollard's (p — l)-method (Proc. Cambridge,Philos. Soc. 76 (1974), 521-528) by replacing the multiplicative group by the group of points on a random,elliptic curve. It is conjectured,that the algorithm,determines,a

  9. Recess Activity and General Health Status among Iranian Elementary Schools’ Pupils

    PubMed Central

    Shaghaghi, Abdolreza; Piri, Massumeh; Allahverdipour, Hamid; Asghari- Jafarabadi, Mohammad

    2013-01-01

    Background: Regular and daily physical activity during childhood and at school is one of the important part of requirements of normal growth, development and well-being. To achieve physical activity promotion among school child aged population recess as outside of class time efforts is scheduled and allows students to engage in physical and social activities. The purpose of the present study was to assess recess activities as well as status of physical activities among a sample of Iranian students at the primary schools. Methods: This cross-sectional study was performed in four randomly selected schools from a list of 26 elementary schools in March, 2012 in the city of Shahindej, located in North-west of Iran. Participants were 439 (10–12 years) elementary schools’. Physical activity level by self-reporting, mental health using the parent-completed Child Health Questionnaire, and happiness was assessed using a Persian translated version of the Subjective Happiness Scale. Hierarchical logistic regression analysis was applied in two steps using the enter method to analyze data in the SPSS version 17. Results: Backward logistic regression analysis showed that gender of the parent who answered the study questions, father’s education, educational grade of children, BMI, physical function, physical health, health status of the children and family function were significantly related to the children’s physical activity level. Conclusion: Promoting parents’ awareness and schools’ staff about importance of physical activities especially in recess times must be an important part of school and community mental health promotion programs. PMID:24688952

  10. Prediction of landslide velocity at given cumulated rainfall values based on analysis of continuous monitoring data using ROC curves: application to the Piagneto landslide (Northern Apennine, Italy)

    NASA Astrophysics Data System (ADS)

    Corsini, Alessandro; Mulas, Marco; Petitta, Marcello; Bonacini, Francesco; Ronchetti, Francesco; Caputo, Giuseppe; Truffelli, Giovanni

    2015-04-01

    A novel approach to predict landslide velocity at given cumulated rainfall values based on the analysis of continuous displacement and rainfall monitoring data by using ROC curves has been developed and tested in the Piagneto landslide (northern Apennines, Italy). It is an active rock slide for which a velocity dataset covering the period October 2009 to December 2014 is available thanks to a total station that has been monitoring tens of prisms at duty cycles of 2 hours. Over the same time frame, an hourly rainfall dataset is available from rain gauges located just a few km away from the landslide. The ROC curve (Receiver Operating Characteristic) is a well-known and widely used method to assess the efficiency of a binary classifier. In this case, it is used to assess the efficiency of different values of cumulated rainfall to determine a given value of velocity in the landslide. Operatively, the daily velocity distributions of selected monitoring prisms is plotted in order to assess upper values at given levels of occurrence probability, i.e. velocity values at the upper 1st,2nd, 3rd quartile and 2 sigma. These velocity values are then classified with respect to daily rainfall cumulated over different time windows (from 1 to 120 days), that are considered singularly or in combination one another. The area under the ROC curves, as well as the max distance from the random line, is used as indicator of performance in order to assess the cumulated rainfall (in terms of amount and duration) showing the higher performance in predicting a defined landslide velocity level. The values obtained with the retrospective analysis of monitoring data, can then be used for prediction of expected velocity levels. This has been verified by using the conventional approach of dividing the dataset in a training and a validation subsets. Results underline the added value of the analysis of long time-series of continuous landslide monitoring data by mean of operational research tools, such as in this case the ROC curves, for extracting information useful for improving the comprehension and the prediction of slope dynamics that, in specific cases, can be of great support to risk management.

  11. Pole tip recession studies of thin-film rigid disk head sliders I. Mechanisms of pole tip recession growth

    Microsoft Academic Search

    Junguo Xu; Bharat Bhushan

    1998-01-01

    Pole tip recession (PTR) results in an increase in spacing between recording elements and magnetic media which is undesirable for high magnetic recording. A methodology for an accurate measurement of PTR using an atomic force microscopy (AFM) was developed. A reliable measurement of PTR with AFM consists of: (1) mounting the sample such that air bearing surface (ABS) is as

  12. Can we differentiate alpine groundwater storages regarding volume and residence time by recession observations, ion composition and tracer balance?

    NASA Astrophysics Data System (ADS)

    Floriancic, Marius; Smoorenburg, Maarten; Margreth, Michael; Naef, Felix

    2015-04-01

    Research on how catchments store and release water is essential to improve flood and low flow prediction in (un)gauged watersheds. Despite their importance for catchment scale assessments on runoff generation, knowledge on storage properties and residence times is still limited. Here we present some approaches to separate different storage types regarding their residence time and a quantification of the volumes of these storages based on a dataset of winter recession observation in the alpine Poschiavino headwater area. This spatially highly resolved dataset of discharge, electric conductivity and ion composition from a watershed with strongly contrasting storage properties, allowed separating three main contributing sources: continuous discharge from bedrock cracks, strongly delayed discharge from thick sediment deposits and fractured rock and rapid discharge from shallow layers. The gradients of the recession curves, the variation of electric conductivity in the river network and calculated tracer balance were used to separate contribution from different sources. Additionally contribution from sedimentary rocks and crystalline layers could be separated based on the variation of ion composition in the water samples. We derived recession curves for a period of four months for the separated storages in different parts of the catchment allowing estimation of the contributed volumes in this time period. Finally the spatial distribution of the storage types could be mapped throughout the catchment based on information like geo(morpho)logical maps, aerial photographs, DEM and field observations. We found significant variation comparing the discharged volume and specific discharge throughout the winter season in the different subcatchments. Constant discharge from bedrock cracks is similar in all catchment parts. Storage in the shallow deposits depleted quickly. High winter discharge could be attributed to thick quaternary deposits contributing during the whole observation period. The western part of the watershed covered by these thick deposits showed the highest contribution throughout the low flow measurement campaign. High contribution was also measured from the sedimentary rocks, covering 7% of the area but contributing 14% to total discharge.

  13. 40 CFR 798.5275 - Sex-linked recessive lethal test in drosophila melanogaster.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ...2014-07-01 2014-07-01 false Sex-linked recessive lethal test in drosophila...GUIDELINES Genetic Toxicity § 798.5275 Sex-linked recessive lethal test in drosophila melanogaster. (a) Purpose. The sex-linked recessive lethal (SLRL)...

  14. 40 CFR 798.5275 - Sex-linked recessive lethal test in drosophila melanogaster.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ...2013-07-01 2013-07-01 false Sex-linked recessive lethal test in drosophila...GUIDELINES Genetic Toxicity § 798.5275 Sex-linked recessive lethal test in drosophila melanogaster. (a) Purpose. The sex-linked recessive lethal (SLRL)...

  15. 40 CFR 798.5275 - Sex-linked recessive lethal test in drosophila melanogaster.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ...2012-07-01 2012-07-01 false Sex-linked recessive lethal test in drosophila...GUIDELINES Genetic Toxicity § 798.5275 Sex-linked recessive lethal test in drosophila melanogaster. (a) Purpose. The sex-linked recessive lethal (SLRL)...

  16. Ready for Recess: A Pilot Study to Increase Physical Activity in Elementary School Children

    ERIC Educational Resources Information Center

    Huberty, Jennifer L.; Siahpush, Mohammad; Beighle, Aaron; Fuhrmeister, Erin; Silva, Pedro; Welk, Greg

    2011-01-01

    Background: Creating an optimal environment at recess may be necessary to maximize physical activity (PA) participation in youth. The purpose of this study was to determine the initial effectiveness of an elementary school recess intervention on the amount of moderate PA (MPA) and vigorous PA (VPA) during recess and the school day. Methods: This…

  17. Conspicuous consumption in a recession: Toning it down or turning it up?

    Microsoft Academic Search

    Joseph C. Nunes; Xavier Drèze; Young Jee Han

    2011-01-01

    The 2008 recession reportedly led to the demise of conspicuous consumption with wealthy consumers abandoning luxury goods that prominently display their brands for more subdued designs. Utilizing data collected before and in the midst of the recession from designer handbag manufacturers, Louis Vuitton and Gucci, we find products introduced during the recession actually display the brand far more prominently than

  18. Accounting for the Great Recession in the UK: Real Business Cycles and Financial Frictions

    Microsoft Academic Search

    Jagjit S. Chadha; James Warren

    2012-01-01

    Using the business cycle accounting (BCA) framework pioneered by Chari, Kehoe and McGratten (2006) we examine the 2008-09 recession in the UK. There has been much commentary on the financial causes of this recession, which we might have expected to shock the equation governing the intertemporal rate of substitution in consumption. However, the recession appears to have been mostly driven

  19. Non-Overweight and Overweight Children's Physical Activity during School Recess

    ERIC Educational Resources Information Center

    Ridgers, Nicola D.; Saint-Maurice, Pedro F.; Welk, Gregory J.; Siahpush, Mohammad; Huberty, Jennifer L.

    2014-01-01

    Objective: Little research has investigated children's physical activity levels during school recess and the contribution of recess to school day physical activity levels by weight status. The aims of this study were to examine non-overweight and overweight children's physical activity levels during school recess, and examine the…

  20. Recessive RYR1 mutations cause unusual congenital myopathy with prominent nuclear internalization and

    E-print Network

    Recessive RYR1 mutations cause unusual congenital myopathy with prominent nuclear internalization Neurobiology 37, 271­284 Recessive RYR1 mutations cause unusual congenital myopathy with prominent nuclear due to recessive mutations in the gene encoding the type 1 muscle ryanodine receptor channel (RYR1

  1. Proposed Strategy for Selection Against Recessive Genetic Defects Through a Combination of Inbreeding and DNA Markers

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Recessive genetic defects are currently on the minds of many cattle breeders. The relatively rapid development of diagnostic DNA tests for recessive defects appears to be a major recent technological advancement. However, the attitude of breeders and breed associations toward recessive defects seems...

  2. Facts and Challenges from the Great Recession for Forecasting and Macroeconomic Modeling

    E-print Network

    Weaver, Harold A. "Hal"

    time series are difference stationary, and occasional mean shifts, parameter instability, stochasticFacts and Challenges from the Great Recession for Forecasting and Macroeconomic Modeling Serena Ng-war recessions in the US in being driven by deleveraging and financial market factors. We document how recessions

  3. Composition-explicit distillation curves of diesel fuel with glycol ether and glycol ester oxygenates: fuel analysis metrology to enable decreased particulate emissions.

    PubMed

    Smith, Beverly L; Ott, Lisa S; Bruno, Thomas J

    2008-10-15

    We recently introduced several important improvements in the measurement of distillation curves of complex fluids. The modifications to the classical measurement provide for (1) a composition-explicit data channel for each distillate fraction (for both qualitative and quantitative analysis), (2) temperature measurements that are true thermodynamic state points that can be modeled with an equation of state, (3) temperature, volume, and pressure measurements of low uncertainty suitable for equation of state development, (4) consistency with a century of historical data, (5) an assessment of the energy content of each distillate fraction, (6) trace chemical analysis of each distillate fraction, and (7) corrosivity assessment of each distillate fraction. We have applied the new method to the measurement of rocket propellant, gasolines, jet fuels, and hydrocarbon crude oils. In this paper we presentthe application of the technique to representative diesel fuel and mixtures of diesel fuel with some of the more promising oxygenating agents; namely, the glycol ethers and glycol esters: tri(propylene glycol) methyl ether (TPM), dibutyl maleate (DBM), and an 80/ 20 (vol/vol) mixture of diethylene glycol methyl ether (DGME) + 1,2-dimethoxyethane (DME) a mixture often referred to as Cetaner. We present not only the distillation curves but also a chemical characterization of each fraction, and discuss the contrasts between the various mixtures. The measurements are significant as an environmental design tool for decreased particulate emissions. PMID:18983093

  4. Isolated Curves for Hyperelliptic Curve Cryptography

    E-print Network

    Wang, Wenhan

    2012-01-01

    We introduce the notion of isolated genus two curves. As there is no known efficient algorithm to explicitly construct isogenies between two genus two curves with large conductor gap, the discrete log problem (DLP) cannot be efficiently carried over from an isolated curve to a large set of isogenous curves. Thus isolated genus two curves might be more secure for DLP based hyperelliptic curve cryptography. We establish results on explicit expressions for the index of an endomorphism ring in the maximal CM order, and give conditions under which the index is a prime number or an almost prime number for three different categories of quartic CM fields. We also derived heuristic asymptotic results on the densities and distributions of isolated genus two curves with CM by any fixed quartic CM field. Computational results, which are also shown for three explicit examples, agree with heuristic prediction with errors within a tolerable range.

  5. Do Trajectories of At-Home Dementia Caregiving Account for Burden After Nursing Home Placement? A Growth Curve Analysis

    PubMed Central

    Newcomer, Robert; Gaugler, Joseph E.

    2010-01-01

    Transitioning to the nursing home setting is a complex process for family caregivers of older adults with dementia. While nursing home placement (NHP) can alleviate certain caregiving responsibilities, new stressors can also emerge. In the present study, the researchers examined how care-related factors can change leading up to NHP and how these factors influence caregiver outcomes following NHP. A sample of 634 family dementia caregivers (N = 634) were surveyed at three six-month intervals prior to NHP and once during the 12 month period following institutionalization. Growth curve modeling revealed dynamic changes in certain factors leading up to NHP (e.g., caregivers’ perceived health), while other factors remained stable (e.g., caregiver burden). Several factors emerged as significant predictors of caregiver burden following NHP, including pre-placement burden and adult day service utilization. For geriatric social workers, these findings may be useful in assessing family caregivers, and in the development and utilization of appropriate interventions. PMID:20853212

  6. Mechanical and optical analysis of large-aperture optics mounted on a frame with a curved surface

    NASA Astrophysics Data System (ADS)

    Su, Ruifeng; Liu, Haitao; Liang, Yingchun; Lu, Lihua; Sun, Fuzhong; Cao, Yongzhi

    2014-03-01

    Motivated by the need to decrease gravitational sag and stress and increase the frequency conversion efficiency of large-aperture optics, a novel mounting configuration in which a set of optics is mechanically mounted to a frame with a curved surface was developed and mechanically and optically analyzed. The effects of an external load on distortion, stress and the induced frequency conversion efficiency were studied, and the changes in these values with varying external load were assessed to determine the optimum mounting configuration. Additionally, the effects of the frame surface topography on distortion, stress and the induced frequency conversion efficiency were studied. The optimum values for distortion, stress and the induced frequency conversion efficiency were determined for different topographies.

  7. Analysis of noise produced by jet impingement near the trailing edge of a flat and a curved plate

    NASA Technical Reports Server (NTRS)

    Mckinzie, D. J., Jr.; Burns, R. J.

    1975-01-01

    The sound fields produced by the interaction of a subsonic cold gas jet with the trailing edge of a large flat plate and a curved plate were analyzed. The analyses were performed to obtain a better understanding of the dominant noise source and the mechanism governing the peak sound-pressure-level frequencies of the broadband spectra. An analytical expression incorporating an available theory and experimental data predicts sound field data over an arc of approximately 105 deg measured from the upstream jet axis for the two independent sets of data. The dominant noise as detected on the impingement side of either plate results from the jet impact (eighth power of the velocity dependence) rather than a trailing-edge disturbance (fifth or sixth power of the velocity dependence). Also, the frequency of the peak SPL may be governed by a phenomenon which produces periodic formation and shedding of ring vortices from the nozzle lip.

  8. Analysis of First Order Reversal Curves in the Thermal Hysteresis of Spin-crossover Nanoparticles within the Mechanoelastic Model

    E-print Network

    Stoleriu, Laurentiu; Chakraborty, Pradip; Hauser, Andreas; Enachescu, Cristian

    2015-01-01

    The recently obtained spin-crossover nanoparticles are possible candidates for applications in the recording media industry as materials for data storage, or as pressure and temperature sensors. For these applications the intermolecular interactions and interactions between spin-crossover nanoparticles are extremely important, as they may be essential factors in triggering the transition between the two stable phases: the high-spin and low-spin ones. In order to find correlations between the distributions in size and interactions and the transition temperatures distribution, we apply the FORC (First Order Reversal Curves) method, using simulations based on a mechanoelastic model applied to 2D triangular lattices composed of molecules linked by springs and embedded in a surfactant. We consider two Gaussian distributions: one of the size of the nanoparticles and one of the elastic interactions between edge spin-crossover molecules and the surfactant molecules. In order to disentangle the kinetic and non-kinetic...

  9. Variability in Proto-planetary Nebulae. IV. Light Curve Analysis of Four Oxygen-rich, F Spectral Type Objects

    NASA Astrophysics Data System (ADS)

    Hrivnak, Bruce J.; Lu, Wenxian; Nault, Kristie A.

    2015-06-01

    We present new light curves covering 14–19 years of observations of four bright proto-planetary nebulae (PPNs), all oxygen-rich and of F spectral type. They each display cyclical light curves with significant variations in amplitude. All four were previously known to vary in light. Our data were combined with published data and searched for periodicity. The results are as follows: IRAS 19475+3119 (HD 331319; 41.0 days), 17436+5003 (HD 161796; 45.2 days), 19386+0155 (101.8 days), and 18095+2704 (113.3 days). The two longer periods are in agreement with previous studies while the two shorter periods each reveal for the first time a dominant period over these long observing intervals. Multiple periods were also found for each object. The secondary periods were all close to the dominant periods, with P2/P1 ranging from 0.86 to 1.06. The variations in color reveal maximum variations in Teff of 400–770 K. These variations are due to pulsations in these post-asymptotic giant branch objects. Maximum seasonal light variations are all less than 0.23 mag (V), consistent for their temperatures and periods with the results of Hrivnak et al. for 12 C-rich PPNs. For all of these PPNs, there is an inverse relationship between period and temperature; however, there is a suggestion that the period–temperature relationship may be somewhat steeper for the O-rich than for the C-rich PPNs.

  10. Mapping of a locus for a familial autosomal recessive idiopathic myoclonic epilepsy of infancy to chromosome 16p13.

    PubMed Central

    Zara, F; Gennaro, E; Stabile, M; Carbone, I; Malacarne, M; Majello, L; Santangelo, R; de Falco, F A; Bricarelli, F D

    2000-01-01

    Myoclonic epilepsies with onset in infancy and childhood are clinically and etiologically heterogeneous. Although genetic factors are thought to play an important role, to date very little is known about the etiology of these disorders. We ascertained a large Italian pedigree segregating a recessive idiopathic myoclonic epilepsy that starts in early infancy as myoclonic seizures, febrile convulsions, and tonic-clonic seizures. We typed 304 microsatellite markers spanning the 22 autosomes and mapped the locus on chromosome 16p13 by linkage analysis. A maximum LOD score of 4.48 was obtained for marker D16S3027 at recombination fraction 0. Haplotype analysis placed the critical region within a 3.4-cM interval between D16S3024 and D16S423. The present report constitutes the first example of an idiopathic epilepsy that is inherited as an autosomal recessive trait. PMID:10741954

  11. Anatomical curve identification

    PubMed Central

    Bowman, Adrian W.; Katina, Stanislav; Smith, Joanna; Brown, Denise

    2015-01-01

    Methods for capturing images in three dimensions are now widely available, with stereo-photogrammetry and laser scanning being two common approaches. In anatomical studies, a number of landmarks are usually identified manually from each of these images and these form the basis of subsequent statistical analysis. However, landmarks express only a very small proportion of the information available from the images. Anatomically defined curves have the advantage of providing a much richer expression of shape. This is explored in the context of identifying the boundary of breasts from an image of the female torso and the boundary of the lips from a facial image. The curves of interest are characterised by ridges or valleys. Key issues in estimation are the ability to navigate across the anatomical surface in three-dimensions, the ability to recognise the relevant boundary and the need to assess the evidence for the presence of the surface feature of interest. The first issue is addressed by the use of principal curves, as an extension of principal components, the second by suitable assessment of curvature and the third by change-point detection. P-spline smoothing is used as an integral part of the methods but adaptations are made to the specific anatomical features of interest. After estimation of the boundary curves, the intermediate surfaces of the anatomical feature of interest can be characterised by surface interpolation. This allows shape variation to be explored using standard methods such as principal components. These tools are applied to a collection of images of women where one breast has been reconstructed after mastectomy and where interest lies in shape differences between the reconstructed and unreconstructed breasts. They are also applied to a collection of lip images where possible differences in shape between males and females are of interest. PMID:26041943

  12. Mutations in EOGT Confirm the Genetic Heterogeneity of Autosomal-Recessive Adams-Oliver Syndrome

    PubMed Central

    Shaheen, Ranad; Aglan, Mona; Keppler-Noreuil, Kim; Faqeih, Eissa; Ansari, Shinu; Horton, Kim; Ashour, Adel; Zaki, Maha S.; Al-Zahrani, Fatema; Cueto-González, Anna M.; Abdel-Salam, Ghada; Temtamy, Samia; Alkuraya, Fowzan S.

    2013-01-01

    Adams-Oliver syndrome (AOS) is a rare, autosomal-dominant or -recessive disorder characterized primarily by aplasia cutis congenita and terminal transverse limb defects. Recently, we demonstrated that homozygous mutations in DOCK6 cause an autosomal-recessive form of AOS. In this study, we sought to determine the contribution of DOCK6 mutations to the etiology of AOS in several consanguineous families. In two of the five families studied, we identified two homozygous truncating mutations (a splice-site mutation and a frameshift duplication). DOCK6 sequencing revealed no mutation in the remaining three families, consistent with their autozygosity mapping and linkage-analysis results, which revealed a single candidate locus in 3p14.1 on three different haplotype backgrounds in the three families. Indeed, exome sequencing in one family revealed one missense mutation in EOGT (C3orf64), and subsequent targeted sequencing of this gene revealed a homozygous missense mutation and a homozygous frameshift deletion mutation in the other two families. EOGT encodes EGF-domain-specific O-linked N-acetylglucosamine (O-GlcNAc) transferase, which is involved in the O-GlcNAcylation (attachment of O-GlcNAc to serine and threonine residues) of a subset of extracellular EGF-domain-containing proteins. It has a documented role in epithelial-cell-matrix interactions in Drosophila, in which deficiency of its ortholog causes wing blistering. Our findings highlight a developmental role of O-GlcNAcylation in humans and expand the genetic heterogeneity of autosomal-recessive AOS. PMID:23522784

  13. Health in financial crises: economic recession and tuberculosis in Central and Eastern Europe.

    PubMed

    Arinaminpathy, Nimalan; Dye, Christopher

    2010-11-01

    The ongoing global financial crisis, which began in 2007, has drawn attention to the effect of declining economic conditions on public health. A quantitative analysis of previous events can offer insights into the potential health effects of economic decline. In the early 1990s, widespread recession across Central and Eastern Europe accompanied the collapse of the Soviet Union. At the same time, despite previously falling tuberculosis (TB) incidence in most countries, there was an upsurge of TB cases and deaths throughout the region. Here, we study the quantitative relationship between the lost economic productivity and excess TB cases and mortality. We use the data of the World Health Organization for TB notifications and deaths from 1980 to 2006, and World Bank data for gross domestic product. Comparing 15 countries for which sufficient data exist, we find strong linear associations between the lost economic productivity over the period of recession for each country and excess numbers of TB cases (r(2) = 0.94, p < 0.001) and deaths (r(2) = 0.94, p < 0.001) over the same period. If TB epidemiology and control are linked to economies in 2009 as they were in 1991 then the Baltic states, particularly Latvia, are now vulnerable to another upturn in TB cases and deaths. These projections are in accordance with emerging data on drug consumption, which indicate that these countries have undergone the greatest reductions since the beginning of 2008. We recommend close surveillance and monitoring during the current recession, especially in the Baltic states. PMID:20427332

  14. Mutations in CERS3 Cause Autosomal Recessive Congenital Ichthyosis in Humans

    PubMed Central

    Marrakchi, Slaheddine; Ribierre, Florence; Kamoun, Bourane; Abid, Leila; Leipoldt, Michael; Turki, Hamida; Schempp, Werner; Heilig, Roland; Lathrop, Mark; Fischer, Judith

    2013-01-01

    Autosomal recessive congenital ichthyosis (ARCI) is a rare genetic disorder of the skin characterized by abnormal desquamation over the whole body. In this study we report four patients from three consanguineous Tunisian families with skin, eye, heart, and skeletal anomalies, who harbor a homozygous contiguous gene deletion syndrome on chromosome 15q26.3. Genome-wide SNP-genotyping revealed a homozygous region in all affected individuals, including the same microdeletion that partially affects two coding genes (ADAMTS17, CERS3) and abolishes a sequence for a long non-coding RNA (FLJ42289). Whereas mutations in ADAMTS17 have recently been identified in autosomal recessive Weill-Marchesani-like syndrome in humans and dogs presenting with ophthalmologic, cardiac, and skeletal abnormalities, no disease associations have been described for CERS3 (ceramide synthase 3) and FLJ42289 so far. However, analysis of additional patients with non-syndromic ARCI revealed a splice site mutation in CERS3 indicating that a defect in ceramide synthesis is causative for the present skin phenotype of our patients. Functional analysis of patient skin and in vitro differentiated keratinocytes demonstrated that mutations in CERS3 lead to a disturbed sphingolipid profile with reduced levels of epidermis-specific very long-chain ceramides that interferes with epidermal differentiation. Taken together, these data present a novel pathway involved in ARCI development and, moreover, provide the first evidence that CERS3 plays an essential role in human sphingolipid metabolism for the maintenance of epidermal lipid homeostasis. PMID:23754960

  15. S-shaped learning curves.

    PubMed

    Murre, Jaap M J

    2014-04-01

    In this article, learning curves for foreign vocabulary words are investigated, distinguishing between a subject-specific learning rate and a material-specific parameter that is related to the complexity of the items, such as the number of syllables. Two experiments are described, one with Turkish words and one with Italian words. In both, S-shaped learning curves were observed, which were most obvious if the subjects were not very familiar with the materials and if they were slow learners. With prolonged learning, the S shapes disappeared. Three different mathematical functions are proposed to explain these S-shaped curves. A further analysis clarifies why S-shaped learning curves may go unnoticed in many experiments. PMID:24065285

  16. Autosomal recessive spino-olivo-cerebellar degeneration without ataxia.

    PubMed Central

    Staal, A; Stefanko, S Z; Jennekens, F G; Vries-Bos, L H; van Gijn, J

    1983-01-01

    Five adult siblings from a sibship of ten suffering from an external ophthalmoplegia with a spastic paraplegia are reported. In addition, optic nerve atrophy was present in three of the patients and dementia in two; extrapyramidal signs and cerebellar ataxia were found only in one patient. Contrary to earlier studies of patients with comparable neurological signs the pattern of inheritance was autosomal recessive. Neuropathological investigation of the index case, who had never shown ataxia, nevertheless showed demyelination of the spinocerebellar and the olivocerebellar pathways, and also a severe loss of Purkinje cells, of cells in Clarke's column and in the inferior olives. The dentate nucleus was severely gliotic but showed no cell loss. Earlier neuropathological investigations of this disorder, but with an autosomal dominant heredity, were incomplete. It is concluded that the five siblings of this family have a unique autosomal recessive disorder, which should be considered a distinct entity. Images PMID:6886703

  17. The Great Recession, Public Transfers, and Material Hardship

    PubMed Central

    Pilkauskas, Natasha V.; Currie, Janet; Garfinkel, Irwin

    2013-01-01

    Economic downturns lead to lost income and increased poverty. Although high unemployment almost certainly also increases material hardship, and government transfers likely decrease hardship, the first relationship has not yet been documented and the second is poorly understood. We use data from five waves of the Fragile Families and Child Well-being Study to study the relationships between unemployment, government transfers, and material hardship. The latest wave of data was collected during the Great Recession, the worst recession since the Great Depression, providing a unique opportunity to look at how high unemployment rates affect the well-being of low income families. We find that the unemployment rate is associated with increased overall material hardship, difficulty paying bills, having utilities disconnected, and with increased usage of TANF, SNAP, UI and Medicaid. If not for SNAP, food hardship might have increased by twice the amount actually observed. PMID:24379487

  18. Gingival Veneer: A Novel Technique of Masking Gingival Recession

    PubMed Central

    Pillai, Arpita; Zade, R.; Amirishetty, Ramesh; Shetty, Sunaina

    2015-01-01

    One of the most distressing aspects of periodontitis is the unesthetic appearance of maxillary and mandibular anteriors. The elongation of the crowns due to root exposure and increased interdental spacing results in unesthetic appearance. Surgical procedures for gingival recession coverage do not have acceptable results in cases of severe gingival recession. So nonsurgical methods like gingival veneers should be considered as a treatment modality in such cases. This article aims to revisit the gingival veneer: its uses, advantages, disadvantages, and its fabrication. The case discussed here highlight clinical situation where the gingival veneer prosthesis helped in achieving optimum esthetics and patient satisfaction thus proving to be a feasible and simple treatment modality in certain clinical cases. This may offer a good interim solution for patients who may wish to have time to consider their options of more advanced and complex treatment. PMID:25738090

  19. A case report on autosomal recessive total congenital anonychia.

    PubMed

    Balta, Ilknur; Kalkan, Goknur

    2013-01-01

    A 21-year-old woman presented with a history of the absence of the nails of all her fingers and toes since birth. Her grandfathers were first degree relatives. Her two brothers (26 and 28 years old) had the same anomalies. Autosomal recessive inheritance of this disease was supported in our cases because the parents were consanguineous and the disease occurred in two brothers and a sister. PMID:23679125

  20. De Barsy syndrome--an autosomal recessive, progeroid syndrome.

    PubMed

    Kunze, J; Majewski, F; Montgomery, P; Hockey, A; Karkut, I; Riebel, T

    1985-11-01

    We report two families with seven siblings with de Barsy syndrome. Characteristic features include severe mental retardation, hypermobility with athetoid movements, grimacing, muscular hypotonia, laxity of small joints and brisk deep tendon reflexes, progeroid aspect with cutis laxa, atrophy of skin with hyperpigmentation, isolated depigmentations, reduction of subcutaneous fatty tissue, translucent vein pattern, short stature, frontal bossing in the young child, large prominent ears with dysplastic helices and corneal clouding or cataracts. The syndrome probably has autosomal recessive inheritance. PMID:4076251

  1. Unusual molecular findings in autosomal recessive spinal muscular atrophy

    Microsoft Academic Search

    G Matthijs; E Schollen; E Legius; K Devriendt; N Goemans; H Kayserili; M Y Apäk; J J Cassiman

    1996-01-01

    All three types of autosomal recessive spinal muscular atrophy map to chromosome 5q11.2-q13.3 and are associated with deletions or mutations of the SMN (survival motor neurone) gene. The availability of a test to distinguish between the SMN gene and its nearly identical centromeric copy cBCD541 allows molecular diagnosis. We have analysed patients from 24 Belgian and 34 Turkish families for

  2. Autosomal recessive renal proximal tubulopathy and hypercalciuria: a new syndrome

    Microsoft Academic Search

    Daniella Magen; Lior Adler; Hana Mandel; Edna Efrati; Israel Zelikovic

    2004-01-01

    Background: The best described primary inherited proximal tubulopathies include X-linked hypercalciuric nephrolithiasis (XLHN), caused by a mutation in the chloride channel gene CLCN5, and classic Fanconi’s syndrome, the genetic basis of which is unknown. The aim of this study is to examine the clinical, biochemical, and genetic characteristics of a highly consanguineous Druze family with autosomal recessive proximal tubulopathy and

  3. Novel ABCA-12 mutations leading to recessive congenital ichthyosis.

    PubMed

    Peterson, Haley; Lofgren, Sabra; Bremmer, Samuel; Krol, Alfons

    2013-01-01

    Mutations in the keratinocyte lipid transporter adenosine triphosphate-binding cassette A12 (ABCA12) are known to cause harlequin ichthyosis. More recently, mutations in this gene have been demonstrated to cause other phenotypes within the spectrum of recessive congenital ichthyosis. We report the case of an infant with novel heterozygous mutations in ABCA12 who exhibited features and a clinical course more consistent with congenital ichthyosiform erythroderma than harlequin ichthyosis. PMID:22299640

  4. Job Loss and Infrastructure Job Creation Spending During the Recession

    Microsoft Academic Search

    Linda Levine

    2009-01-01

    [Excerpt] After the long economic expansion that characterized much of the current decade, the nation entered its eleventh postwar recession in December 2007. The unemployment rate, which is a lagging economic indicator, did not start to rise until May 2008 when it jumped 0.5 percentage points to 5.5%. By December 2008, the unemployment rate exceeded 7.0% and well over 600,000

  5. Melting Curve Analysis after T Allele Enrichment (MelcaTle) as a Highly Sensitive and Reliable Method for Detecting the JAK2V617F Mutation

    PubMed Central

    Morishita, Soji; Takahashi, Kochi; Araki, Marito; Hironaka, Yumi; Sunami, Yoshitaka; Edahiro, Yoko; Tsutsui, Miyuki; Ohsaka, Akimichi; Tsuneda, Satoshi; Komatsu, Norio

    2015-01-01

    Detection of the JAK2V617F mutation is essential for diagnosing patients with classical myeloproliferative neoplasms (MPNs). However, detection of the low-frequency JAK2V617F mutation is a challenging task due to the necessity of discriminating between true-positive and false-positive results. Here, we have developed a highly sensitive and accurate assay for the detection of JAK2V617F and named it melting curve analysis after T allele enrichment (MelcaTle). MelcaTle comprises three steps: 1) two cycles of JAK2V617F allele enrichment by PCR amplification followed by BsaXI digestion, 2) selective amplification of the JAK2V617F allele in the presence of a bridged nucleic acid (BNA) probe, and 3) a melting curve assay using a BODIPY-FL-labeled oligonucleotide. Using this assay, we successfully detected nearly a single copy of the JAK2V617F allele, without false-positive signals, using 10 ng of genomic DNA standard. Furthermore, MelcaTle showed no positive signals in 90 assays screening healthy individuals for JAK2V617F. When applying MelcaTle to 27 patients who were initially classified as JAK2V617F-positive on the basis of allele-specific PCR analysis and were thus suspected as having MPNs, we found that two of the patients were actually JAK2V617F-negative. A more careful clinical data analysis revealed that these two patients had developed transient erythrocytosis of unknown etiology but not polycythemia vera, a subtype of MPNs. These findings indicate that the newly developed MelcaTle assay should markedly improve the diagnosis of JAK2V617F-positive MPNs. PMID:25794279

  6. Understanding curved detonation waves

    SciTech Connect

    Bukiet, B.G. (New Jersey Inst. of Tech., Newark, NJ (United States). Dept. of Mathematics); Menikoff, R. (Los Alamos National Lab., NM (United States))

    1992-01-01

    A wave curve is the set of final states to which an initial state may be connected by a traveling wave. In gas dynamics, for example, the wave curve consists of the shock Hugoniot curve for compressive waves and the rarefaction curve for expansive waves. In this paper, we discuss the wave curve for an undriven planar detonation and for general planar detonations. We then extend the wave curve concept to detonations in converging and diverging geometry. We also discuss the application of these wave curves to the numerical computation of detonation problems.

  7. Understanding curved detonation waves

    SciTech Connect

    Bukiet, B.G. [New Jersey Inst. of Tech., Newark, NJ (United States). Dept. of Mathematics; Menikoff, R. [Los Alamos National Lab., NM (United States)

    1992-10-01

    A wave curve is the set of final states to which an initial state may be connected by a traveling wave. In gas dynamics, for example, the wave curve consists of the shock Hugoniot curve for compressive waves and the rarefaction curve for expansive waves. In this paper, we discuss the wave curve for an undriven planar detonation and for general planar detonations. We then extend the wave curve concept to detonations in converging and diverging geometry. We also discuss the application of these wave curves to the numerical computation of detonation problems.

  8. Growth Curve Models for the Analysis of Phenotype Arrays for a Systems Biology Overview of Yersinia pestis

    SciTech Connect

    Fodor, I K; Holtz-Morris, A E; McCutchen-Maloney, S L

    2005-09-08

    The Phenotype MicroArray technology of Biolog, Inc. (Hayward, CA) measures the respiration of cells as a function of time in thousands of microwells simultaneously, and thus provides a high-throughput means of studying cellular phenotypes. The microwells contain compounds involved in a number of biochemical pathways, as well as chemicals that test the sensitivity of cells against antibiotics and stress. While the PM experimental workflow is completely automated, statistical methods to analyze and interpret the data are lagging behind. To take full advantage of the technology, it is essential to develop efficient analytical methods to quantify the information in the complex datasets resulting from PM experiments. We propose the use of statistical growth-curve models to rigorously quantify observed differences in PM experiments, in the context of the growth and metabolism of Yersinia pestis cells grown under different physiological conditions. The information from PM experiments complement genomic and proteomic results and can be used to identify gene function and in drug development. Successful coupling of phenomics results with genomics and proteomics will lead to an unprecedented ability to characterize bacterial function at a systems biology level.

  9. Design, analysis, and fabrication of a pressure box test fixture for tension damage tolerance testing of curved fuselage panels

    NASA Technical Reports Server (NTRS)

    Smith, P. J.; Bodine, J. B.; Preuss, C. H.; Koch, W. J.

    1993-01-01

    A pressure box test fixture was designed and fabricated to evaluate the effects of internal pressure, biaxial tension loads, curvature, and damage on the fracture response of composite fuselage structure. Previous work in composite fuselage tension damage tolerance, performed during NASA contract NAS1-17740, evaluated the above effects on unstiffened panels only. This work extends the tension damage tolerance testing to curved stiffened fuselage crown structure that contains longitudinal stringers and circumferential frame elements. The pressure box fixture was designed to apply internal pressure up to 20 psi, and axial tension loads up to 5000 lb/in, either separately or simultaneously. A NASTRAN finite element model of the pressure box fixture and composite stiffened panel was used to help design the test fixture, and was compared to a finite element model of a full composite stiffened fuselage shell. This was done to ensure that the test panel was loaded in a similar way to a panel in the full fuselage shell, and that the fixture and its attachment plates did not adversely affect the panel.

  10. FOXE3 plays a significant role in autosomal recessive microphthalmia

    PubMed Central

    Reis, Linda M.; Tyler, Rebecca C.; Schneider, Adele; Bardakjian, Tanya; Stoler, Joan M.; Melancon, Serge B.; Semina, Elena V.

    2010-01-01

    FOXE3 forkhead transcription factor is essential to lens development in vertebrates. The eyes of Foxe3/foxe3-deficient mice and zebrafish fail to develop normally. In humans, autosomal dominant and recessive mutations in FOXE3 have been associated with variable phenotypes including anterior segment anomalies, cataract and microphthalmia. We undertook sequencing of FOXE3 in 116 probands with a spectrum of ocular defects ranging from anterior segment dysgenesis and cataract to anophthalmia/microphthalmia. Recessive mutations in FOXE3 were found in four of 26 probands affected with bilateral microphthalmia (15% of all bilateral microphthalmia and 100% of consanguineous families with this phenotype). FOXE3-positive microphthalmia was accompanied by aphakia and/or corneal defects; no other associated systemic anomalies were observed in FOXE3-positive families. The previously reported c.720C>A (p.C240X) nonsense mutation was identified in two additional families in our sample and therefore appears to be recurrent, now reported in three independent microphthalmia families of varied ethnic backgrounds. Several missense variants were identified at varying frequencies in patient and control groups with some apparently being race-specific, which underscores the importance of utilizing race/ethnicity-matched control populations in evaluating the relevance of genetic screening results. In conclusion, FOXE3 mutations represent an important cause of nonsyndromic autosomal recessive bilateral microphthalmia. PMID:20140963

  11. Correlation between PLD repair capacity and the survival curve of human fibroblasts in exponential growth phase: analysis in terms of several parameters

    SciTech Connect

    Fertil, B.; Deschavanne, P.J.; Debieu, D.; Malaise, E.P.

    1988-10-01

    Published data on the in vitro radiosensitivity of 46 nontransformed fibroblasts of different genetic origins studied in plateau phase with immediate or delayed plating were used to investigate to what extent potentially lethal damage repair capacity is related to intrinsic radiosensitivity (i.e., irradiated in exponential growth phase). While most of the survival curve analysis is conducted in terms of D0, Dq, and the mean inactivation dose D, some of the data are also discussed in terms of the linear-quadratic model parameter alpha. Using D it is shown that: (i) the radiosensitivity of human fibroblasts in exponential growth phase does not significantly differ from that of plateau-phase fibroblasts with immediate plating; (ii) the radiosensitivity of plateau-phase cells with delayed plating is correlated to the radiosensitivity of cells with immediate plating: the more radioresistant the cell strain in exponential growth phase, the higher its repair capacity; (iii) the repair capacity of the cell strains is related to their genetic origin. In conclusion, we suggest that the survival curve of growing cells depends on the repair capacity of the cells.

  12. Analytical solutions for recession analyses of sloping aquifers - applicability on relict rock glaciers in alpine catchments

    NASA Astrophysics Data System (ADS)

    Pauritsch, Marcus; Birk, Steffen; Hergarten, Stefan; Kellerer-Pirklbauer, Andreas; Winkler, Gerfried

    2014-05-01

    Rock glaciers as aquifer systems in alpine catchments may strongly influence the hydrological characteristics of these catchments. Thus, they have a high impact on the ecosystem and potential natural hazards such as for example debris flow. Therefore, knowledge of the hydrodynamic processes, internal structure and properties of these aquifers is important for resource management and risk assessment. The investigation of such aquifers often turns out to be expensive and technically complicated because of their strongly limited accessibility. Analytical solutions of discharge recession provide a quick and easy way to estimate aquifer parameters. However, due to simplifying assumptions the validity of the interpretation is often questionable. In this study we compared results of an analytical solution of discharge recessions with results based on a numerical model. This was done in order to analyse the range of uncertainties and the applicability of the analytical method in alpine catchment areas. The research area is a 0.76 km² large catchment in the Seckauer Tauern Range, Austria. The dominant aquifer in this catchment is a rock glacier, namely the Schöneben Rock Glacier. This relict rock glacier (i.e. containing no permafrost at present) covers an area of 0.11 km² and is drained by one spring at the rock glacier front. The rock glacier consists predominantly of gneissic sediments (mainly coarse-grained, blocky at the surface) and extends from 1720 to 1905 m a.s.l.. Discharge of the rock glacier spring is automatically measured since 2002. Electric conductivity and water temperature is monitored since 2008. An automatic weather station was installed in 2011 in the central part of the catchment. Additionally data of geophysical surveys (refraction seismic and ground penetrating radar) have been used to analyse the base slope and inner structure of the rock glacier. The measured data are incorporated into a numerical model implemented in MODFLOW. The numerical model was then compared to the analytical solution based on the one dimensional Boussinesq equation for unconfined flow in sloping aquifers. Field observations as well as results from the numerical model suggest that the rock glacier has a complex internal structure with zones of low hydraulic conductivity and a high conductive layer on top. The analytical solution attempts to represent this heterogeneous aquifer by an equivalent homogeneous medium. However, as the relative contribution of the different aquifer components varies throughout the recession, the parameter estimates are not easily interpreted in terms of actual aquifer properties. Employing analytical solutions for recession analysis in this type of setting therefore requires a sound understanding of the internal structure and its influence on the flow and storage processes within the rock glacier.

  13. Analysis of the width-[Formula: see text] non-adjacent form in conjunction with hyperelliptic curve cryptography and with lattices.

    PubMed

    Krenn, Daniel

    2013-06-17

    In this work the number of occurrences of a fixed non-zero digit in the width-[Formula: see text] non-adjacent forms of all elements of a lattice in some region (e.g. a ball) is analysed. As bases, expanding endomorphisms with eigenvalues of the same absolute value are allowed. Applications of the main result are on numeral systems with an algebraic integer as base. Those come from efficient scalar multiplication methods (Frobenius-and-add methods) in hyperelliptic curves cryptography, and the result is needed for analysing the running time of such algorithms. The counting result itself is an asymptotic formula, where its main term coincides with the full block length analysis. In its second order term a periodic fluctuation is exhibited. The proof follows Delange's method. PMID:23805020

  14. Computerised curve deconvolution of TL/OSL curves using a popular spreadsheet program.

    PubMed

    Afouxenidis, D; Polymeris, G S; Tsirliganis, N C; Kitis, G

    2012-05-01

    This paper exploits the possibility of using commercial software for thermoluminescence and optically stimulated luminescence curve deconvolution analysis. The widely used software package Microsoft Excel, with the Solver utility has been used to perform deconvolution analysis to both experimental and reference glow curves resulted from the GLOw Curve ANalysis INtercomparison project. The simple interface of this programme combined with the powerful Solver utility, allows the analysis of complex stimulated luminescence curves into their components and the evaluation of the associated luminescence parameters. PMID:21765155

  15. Identification of Two Novel Compound Heterozygous PTPRQ Mutations Associated with Autosomal Recessive Hearing Loss in a Chinese Family

    PubMed Central

    Han, Ming-Yu; Yuan, Yong-Yi; Xu, Jin-Cao; Xin, Feng; Zhang, Mei-Guang; Huang, Sha-Sha; Wang, Guo-Jian; Kang, Dong-Yang; Guan, Li-Ping; Zhang, Jian-Guo; Dai, Pu

    2015-01-01

    Mutations in PTPRQ are associated with deafness in humans due to defects of stereocilia in hair cells. Using whole exome sequencing, we identified responsible gene of family 1572 with autosomal recessively non-syndromic hearing loss (ARNSHL). We also used DNA from 74 familial patients with ARNSHL and 656 ethnically matched control chromosomes to perform extended variant analysis. We identified two novel compound heterozygous missense mutations, c. 3125 A>G p.D1042G (maternal allele) and c.5981 A>G p.E1994G (paternal allele), in the PTPRQ gene, as the cause of recessively inherited sensorineural hearing loss in family 1572. Both variants co-segregated with hearing loss phenotype in family 1572, but were absent in 74 familial patients. Heterozygosity for c. 3125 A>G was identified in two samples from unaffected Chinese individuals (656 chromosomes). Therefore, the hearing loss in this family was caused by two novel compound heterozygous mutations in PTPRQ. PMID:25919374

  16. Two sisters reveal autosomal recessive inheritance of epidermodysplasia verruciformis: a case report

    PubMed Central

    2014-01-01

    Background Epidermodysplasia verruciformis is a rare genodermatosis characterized by a unique susceptibility to cutaneous human papillomaviruses infection. Most patients show autosomal recessive patterns of inheritance. Case presentation We report a case of two sisters with clinically epidermodysplasia verruciformis specific lesions on the face, neck, trunk, and extremities. PCR analysis indicated the presence of human papillomavirus type 5 in the lesions. Electron microscopic examination showed viral-like particles in keratinocyte nuclei and the stratum corneum of the epidermodysplasia verruciformis lesions. In addition, we examined the EVER1 and EVER2 genes using eight different primer pairs without finding any nonsense or frameshift mutations in the gDNA from lymphocytes of the elder sister. Conclusions In this report, the patient’s parents did not have epidermodysplasia verruciformis lesions or a consanguineous marriage. EV did not develop in the elder sister until five years of age, so the parents did not perceive EV as an inherited disease. The probability that EV developed in both sisters was only 6.25%. Thus, it is rare for both sisters to develop epidermodysplasia verruciformis lesions considering that the parents were presumed to be carriers and the disease reveal an autosomal recessive pattern of inheritance. PMID:25048734

  17. Autosomal Recessive Dilated Cardiomyopathy due to DOLK Mutations Results from Abnormal Dystroglycan O-Mannosylation

    PubMed Central

    Morava, Eva; Riemersma, Moniek; Schuurs-Hoeijmakers, Janneke H. M.; Absmanner, Birgit; Verrijp, Kiek; van den Akker, Willem M. R.; Huijben, Karin; Steenbergen, Gerry; van Reeuwijk, Jeroen; Jozwiak, Adam; Zucker, Nili; Lorber, Avraham; Lammens, Martin; Knopf, Carlos; van Bokhoven, Hans; Grünewald, Stephanie; Lehle, Ludwig; Kapusta, Livia; Mandel, Hanna; Wevers, Ron A.

    2011-01-01

    Genetic causes for autosomal recessive forms of dilated cardiomyopathy (DCM) are only rarely identified, although they are thought to contribute considerably to sudden cardiac death and heart failure, especially in young children. Here, we describe 11 young patients (5–13 years) with a predominant presentation of dilated cardiomyopathy (DCM). Metabolic investigations showed deficient protein N-glycosylation, leading to a diagnosis of Congenital Disorders of Glycosylation (CDG). Homozygosity mapping in the consanguineous families showed a locus with two known genes in the N-glycosylation pathway. In all individuals, pathogenic mutations were identified in DOLK, encoding the dolichol kinase responsible for formation of dolichol-phosphate. Enzyme analysis in patients' fibroblasts confirmed a dolichol kinase deficiency in all families. In comparison with the generally multisystem presentation in CDG, the nonsyndromic DCM in several individuals was remarkable. Investigation of other dolichol-phosphate dependent glycosylation pathways in biopsied heart tissue indicated reduced O-mannosylation of alpha-dystroglycan with concomitant functional loss of its laminin-binding capacity, which has been linked to DCM. We thus identified a combined deficiency of protein N-glycosylation and alpha-dystroglycan O-mannosylation in patients with nonsyndromic DCM due to autosomal recessive DOLK mutations. PMID:22242004

  18. Autosomal recessive dilated cardiomyopathy due to DOLK mutations results from abnormal dystroglycan O-mannosylation.

    PubMed

    Lefeber, Dirk J; de Brouwer, Arjan P M; Morava, Eva; Riemersma, Moniek; Schuurs-Hoeijmakers, Janneke H M; Absmanner, Birgit; Verrijp, Kiek; van den Akker, Willem M R; Huijben, Karin; Steenbergen, Gerry; van Reeuwijk, Jeroen; Jozwiak, Adam; Zucker, Nili; Lorber, Avraham; Lammens, Martin; Knopf, Carlos; van Bokhoven, Hans; Grünewald, Stephanie; Lehle, Ludwig; Kapusta, Livia; Mandel, Hanna; Wevers, Ron A

    2011-12-01

    Genetic causes for autosomal recessive forms of dilated cardiomyopathy (DCM) are only rarely identified, although they are thought to contribute considerably to sudden cardiac death and heart failure, especially in young children. Here, we describe 11 young patients (5-13 years) with a predominant presentation of dilated cardiomyopathy (DCM). Metabolic investigations showed deficient protein N-glycosylation, leading to a diagnosis of Congenital Disorders of Glycosylation (CDG). Homozygosity mapping in the consanguineous families showed a locus with two known genes in the N-glycosylation pathway. In all individuals, pathogenic mutations were identified in DOLK, encoding the dolichol kinase responsible for formation of dolichol-phosphate. Enzyme analysis in patients' fibroblasts confirmed a dolichol kinase deficiency in all families. In comparison with the generally multisystem presentation in CDG, the nonsyndromic DCM in several individuals was remarkable. Investigation of other dolichol-phosphate dependent glycosylation pathways in biopsied heart tissue indicated reduced O-mannosylation of alpha-dystroglycan with concomitant functional loss of its laminin-binding capacity, which has been linked to DCM. We thus identified a combined deficiency of protein N-glycosylation and alpha-dystroglycan O-mannosylation in patients with nonsyndromic DCM due to autosomal recessive DOLK mutations. PMID:22242004

  19. AAV-mediated gene therapy in mouse models of recessive retinal degeneration

    PubMed Central

    Pang, Ji-jing; Lei, Lei; Dai, Xufeng; Shi, Wei; Liu, Xuan; Dinculescu, Astra; McDowell, J. Hugh

    2013-01-01

    In recent years, more and more mutant genes that cause retinal diseases have been detected. At the same time, many naturally occurring mouse models of retinal degeneration have also been found, which show similar changes to human retinal diseases. These, together with improved viral vector quality allow more and more traditionally incurable inherited retinal disorders to become potential candidates for gene therapy. Currently, the most common vehicle to deliver the therapeutic gene into target retinal cells is the adeno-associated viral vector (AAV). Following delivery to the immuno-priviledged subretinal space, AAV-vectors can efficiently target both retinal pigment epithelium and photoreceptor cells, the origin of most retinal degenerations. This review focuses on the AAV-based gene therapy in mouse models of recessive retinal degenerations, especially those in which delivery of the correct copy of the wild-type gene has led to significant beneficial effects on visual function, as determined by morphological, biochemical, electroretinographic and behavioral analysis. The past studies in animal models and ongoing successful LCA2 clinical trials, predict a bright future for AAV gene replacement treatment for inherited recessive retinal diseases. PMID:22300136

  20. A dimensional analysis interpretation to grain size and loading frequency dependencies of the Paris and Wöhler curves

    Microsoft Academic Search

    O. Plekhov; M. Paggi; O. Naimark; A. Carpinteri

    2011-01-01

    In this paper, a mathematical model based on dimensional analysis and incomplete self-similarity is proposed for the interpretation of the grain size and loading frequency effects on the Paris and Wöhler regimes in metals. In particular, it is demonstrated that these effects correspond to a violation of the physical similitude hypothesis underlying the simplest Paris’ and Wöhler power-law fatigue relationships.

  1. A statistical model for the analysis and prediction of the effect of neutron irradiation on Charpy impact energy curves

    Microsoft Academic Search

    P. L. Windle; M. Crowder; R. Moskovic

    1996-01-01

    The structural integrity safety assessments of nuclear reactor pressure vessels are based, in part, on a prediction of the effect of neutron irradiation on material properties. Databases which monitor this effect are often made up of Charpy absorbed energy measurements. This article presents a generally applicable, new and statistically rigorous method of analysis in which any prior belief as to

  2. Assessing the Impact of Family Process on Rural African American Adolescents' Competence and Behavior Using Latent Growth Curve Analysis

    ERIC Educational Resources Information Center

    Toldson, Ivory A.

    2006-01-01

    A study examines the long-term effects of a family process program on social and cognitive competence and aggressive and deviant behavior among rural African American adolescents. Results suggest that family processes influence the status and changes in adolescent competence and behavior, while analysis of covariant structures suggest that…

  3. N=1 Curve

    E-print Network

    Dan Xie

    2014-09-29

    N=1 curve is defined for four dimensional class S theory using Cayley-Hamilton theorem for two commuting matrices. The curve consists of three ingredients: 1: A set of N+1 degree N equations defining a curve; 2: a set of constraints relating the coefficients in the curve; 3: a canonically defined differential. We then extract from spectral curve various physical information such as the space of moduli fields, chiral ring relations, full moduli space, etc. Many examples are discussed, and the curve recovers the intricate vacua structure which often involves highly non-trivial field theory dynamics such as monopole condensation, dynamical generated superpotential, Seiberg duality, etc.

  4. Development of a high-resolution melting curve analysis screening test for SRSF2 splicing factor gene mutations in myelodysplastic syndromes.

    PubMed

    Garza, Eduardo; Fabiani, Emiliano; Noguera, Nelida; Panetta, Paola; Piredda, Maria L; Borgia, Loredana; Maurillo, Luca; Catalano, Gianfranco; Voso, Maria T; Lo-Coco, Francesco

    2015-01-01

    Somatic mutations of the spliceosome machinery have been recently identified by whole genome analysis in hematologic diseases, such as myelodysplastic syndrome, chronic lymphocytic leukemia, myeloproliferative neoplasms, acute myeloid leukemia, and advanced forms of mastocytosis, and also in nonhematologic conditions. SRSF2 is a member of the serine/arginine-rich family pre-mRNA splicing factors that plays a role in mRNA export from the nucleus and translation. We describe a high-resolution melting (HRM) curve analysis to screen for SRSF2 hotspot mutations in a fast, sensitive, and reliable way. Fifty bone marrow samples from patients with myelodysplastic syndrome were analyzed by the HRM assay and by direct sequencing. HRM screening identified four melting patterns corresponding to a negative (wild-type) group and three different mutated groups. Each mutated group was identified according to the positive control used: P95H, P95L, and P95R, respectively. An HRM mutated pattern was identified in seven patients. Positive and negative results from HRM were compared with direct sequencing results with a sensitivity and specificity of 100% (95% CI, 0.56-1, and 95% CI, 0.89-1, respectively). Analytical sensitivity analysis revealed a detection threshold of up to 1:9 (mutated/wild type) dilution. This rapid screening method may provide useful information for clinical decision making and be helpful to optimize laboratory resources and reduce turnaround time. PMID:25445211

  5. Contemplation of the Surgical Normogram of Lateral Rectus Recession for Exotropia Associated with Superior Oblique Palsy

    PubMed Central

    Lee, Joo-Yeon; Yi, Sung-Tae; Lee, Tae-Eun; Cho, Yoonae A.

    2012-01-01

    Purpose To suggest a surgical normogram for lateral rectus recession in exotropia associated with unilateral or bilateral superior oblique muscle palsy (SOP). Methods We retrospectively reviewed the charts of 71 patients with exotropia who were successfully corrected over one year. Each patient had undergone unilateral or bilateral rectus recession associated with uni- or bilateral inferior oblique (IO) 14 mm recession, using a modified surgical normogram for lateral rectus (LR) recession, which resulted in 1 to 2 mm of reduction of LR recession. We divided all patients into 2 groups, the 34 patients who had undergone LR recession with unilateral IO (UIO) recession group and the remaining 37 patients who had undergone LR recession with bilateral IO (BIO) recession group. Lateral incomitancy was defined when the exoangle was reduced by more than 20% compared to the primary gaze angle. The surgical effects (prism diopters [PD]/mm) of LR recession were compared between the two groups using the previous surgical normogram as a reference (Parks' normogram). Results The mean preoperative exodeviation was 20.4 PD in the UIO group and 26.4 PD in the BIO group. The recession amount of the lateral rectus muscle ranged from 4 to 8.5 mm in the UIO group and 5 to 9 mm in the BIO group. Lateral incomitancy was noted as 36.4% and 70.3% in both groups, respectively (p = 0.02). The effect of LR recession was 3.23 ± 0.84 PD/mm in the UIO group and 2.98 ± 0.62 PD/mm in the BIO group and there was no statistically significant difference between two the groups (p = 0.15). Conclusions Reduction of the LR recession by about 1 to 2 mm was successful and safe to prevent overcorrection when using on IO weakening procedure, irrespective of the laterality of SOP. PMID:22670076

  6. Analysis of heterologous interacting systems by sedimentation velocity: curve fitting algorithms for estimation of sedimentation coefficients, equilibrium and kinetic constants

    Microsoft Academic Search

    Walter F. Stafford; Peter J. Sherwood

    2004-01-01

    Analytical ultracentrifugation (AUC) has played and will continue to play an important role in the investigation of protein–protein, protein–DNA and protein–ligand interactions. A major advantage of AUC over other methods is that it allows the analysis of systems free in solution in nearly any buffer without worry about spurious interactions with a supporting matrix. Large amounts of high-quality data can

  7. High-Resolution DNA Melt Curve Analysis of the Clustered, Regularly Interspaced Short-Palindromic-Repeat Locus of Campylobacter jejuni

    Microsoft Academic Search

    Erin P. Price; Helen Smith; Flavia Huygens; Philip M. Giffard

    2007-01-01

    A novel method for genotyping the clustered, regularly interspaced short-palindromic-repeat (CRISPR) locus of Campylobacter jejuni is described. Following real-time PCR, CRISPR products were subjected to high-resolution melt (HRM) analysis, a new technology that allows precise melt profile determination of amplicons. This investigation shows that the CRISPR HRM assay provides a powerful addition to existing C. jejuni genotyping methods and emphasizes

  8. Pricing Options With Curved Boundaries

    Microsoft Academic Search

    Naoto Kunitomo; Masayuki Ikeda

    1992-01-01

    This paper provides a general valuation method for the European options whose payoff is restricted by curved boundaries contractually set on the underlying asset price process when it follows the geometric Brownian motion. Our result is based on the generalization of the Levy formula on the Brownian motion by T. W. Anderson in sequential analysis. We give the explicit probability

  9. An extraordinary origami curve

    Microsoft Academic Search

    Frank Herrlich; Gabriela Schmithusen

    2008-01-01

    We study a special Teichmueller curve in the moduli space of curves of genus\\u000a3 that is intersected by infinitely many other Teichmueller curves. The Veech\\u000agroup of the underlying translation surface is SL_2(Z). All occurring\\u000aTeichmueller curves are induced by origamis, i.e. unramified coverings of the\\u000aonce punctured torus.

  10. Size determination of superconducting MgB2 powder from magnetization curve, image analysis and surface area measurements

    NASA Astrophysics Data System (ADS)

    Vignolo, M.; Bovone, G.; Bellingeri, E.; Bernini, C.; Romano, G.; Buscaglia, M. T.; Buscaglia, V.; Siri, A. S.

    2014-06-01

    This paper reports on a method for estimating the average grain size of superconducting nanoparticles through their magnetic properties. The use of SQUID magnetometry to determine the average MgB2 particle size was investigated and the results were compared with those of several different techniques. In particular, the data obtained from zero field cooled magnetization measurements as a function of the temperature were compared with the results obtained by the scanning electron microscopy and Brunauer-Emmett-Teller techniques. The particle magnetization was measured by a commercial SQUID magnetometer in a magnetic field (10 G) and at temperatures ranging from 5 to 50 K by dispersing the powders in a grease medium. The grain size was obtained by fitting the data taking into account the Ginzburg-Landau temperature dependence of the London penetration depth. Variations in typical modeling parameters were explored in order to gain a better picture of the average grain size and the effectiveness of various measurement techniques. We find that it is possible to use the magnetization measurements to determine the average grain size, even though an SEM analysis coupled to the image analysis allows the extraction of more information about the grain-size distribution. Furthermore, a Matlab routine has been developed in order to automatically analyze several SEM images.

  11. The Prompt-afterglow Connection in Gamma-ray Bursts: a Comprehensive Statistical Analysis of Swift X-ray Light-curves

    NASA Technical Reports Server (NTRS)

    Margutti, R.; Zaninoni, E.; Bernardini, M. G.; Chincarini, G.; Pasotti, F.; Guidorzi, C.; Angelini, Lorella; Burrows, D. N.; Capalbi, M.; Evans, P. A.; Gehrels, Neil; Kennea, J.; Mangano, V.; Moretti, A.; Nousek, J.; Osborne, J. P.; Page, K. L.; Perri, M.; Racusin, Judith Lea; Romano, P.; Sbarufatti, B.; Stafford, M.; Stamatikos, Michael

    2012-01-01

    We present a comprehensive statistical analysis of Swift X-ray light-curves of Gamma- Ray Bursts (GRBs) collecting data from more than 650 GRBs discovered by Swift and other facilities. The unprecedented sample size allows us to constrain the rest-frame X-ray properties of GRBs from a statistical perspective, with particular reference to intrinsic time scales and the energetics of the different light-curve phases in a common rest-frame 0.3-30 keV energy band. Temporal variability episodes are also studied and their properties constrained. Two fundamental questions drive this effort: i) Does the X-ray emission retain any kind of "memory" of the prompt ?-ray phase? ii) Where is the dividing line between long and short GRB X-ray properties? We show that short GRBs decay faster, are less luminous and less energetic than long GRBs in the X-rays, but are interestingly characterized by similar intrinsic absorption. We furthermore reveal the existence of a number of statistically significant relations that link the X-ray to prompt ?-ray parameters in long GRBs; short GRBs are outliers of the majority of these 2-parameter relations. However and more importantly, we report on the existence of a universal 3-parameter scaling that links the X-ray and the ?-ray energy to the prompt spectral peak energy of both long and short GRBs: E(sub X,iso)? E(sup 1.00+/-0.06)(sub ?,iso) /E(sup 0.60+/-0.10)(sub pk).

  12. Unusual autosomal recessive lymphatic anomalies in two unrelated Amish families.

    PubMed

    Williams, M S; Josephson, K D

    1997-12-19

    We report on two unrelated Amish families with familial occurrence of unusual lymphatic anomalies. The first family had two children, a boy and a girl, with congenital chylothorax both of whom died as a consequence of this condition (one prenatally and one neonatally). The second family has two brothers with isolated cystic hygroma. Neither family has any other individuals affected with any type of lymphatic anomaly. Differential diagnosis and presumed autosomal recessive inheritance pattern will be discussed. Familial cystic hygroma not associated with hydrops fetalis and neonatal death has not been reported previously. PMID:9415686

  13. Mars: South Polar Spring Recession as observed by CRISM

    NASA Astrophysics Data System (ADS)

    Brown, A.; Roush, T. L.; Wiseman, S.; McGuire, P.; Wolff, M.; Smith, M.

    2007-12-01

    We are creating a seasonal mosaic of CRISM multispectral data for each MSP (multispectral) image obtained in the south polar region (all regions poleward of 55 deg S) since the start of the MRO primary mission. This effort compliments high resolution targeted observations of the South Polar Cryptic Region (Titus et al., 2007) and OMEGA observations of the south polar cap during spring recession (Langevin et al., 2007). Langevin et al. presented similar maps at 1-10km/pixel - CRISM multispectral observations used here have a nominal resolution of 200m (Seelos, 2007). A similar CRISM multispectral mosaic has been constructed for the north polar region by Seelos et al. (Seelos et al., 2007). Science objectives of this investigation include: 1. High resolution (200m/pixel) multispectral observations of CO2 and H2O seasonal distribution, 2. Observing the point where Cap Recession Observations indicate CO2 has Ultimately Sublimated (CROCUS) line (Kieffer et al., 2000) as a function of solar longitude (ls), 3. Observations of changes in CO2 grain size linked to seasonal brightening of the polar high latitude areas (Langevin et al., 2007), and 200m/pixel observations of dust cover linked to cold jets in the Cyptic Region (Kieffer et al., 2000; Langevin et al., 2007), 4. Observations of small water ice patches in late southern spring (Langevin et al., 2007), 5. Development of climate-based atmospheric correction for use with multispectral data based on TES climatology and DISORT. We will report on the progress of our investigation and present high resolution multispectral mosaics of the south polar cap during spring recession and compare them to data from previous years. References Kieffer, H., et al., 2000. Mars south polar spring and summer behavior observed by TES: Seasonal cap evolution controlled by frost grain size. JGR 105, 9653-9700. Langevin, Y., et al., 2007. Observations of the south seasonal cap of Mars during recession in 2004-2006 by the OMEGA visible/near-infrared imaging spectrometer on board Mars Express. JGR 112, 10.1029/2006JE002841. Seelos, F. P., et al., 2007. CRISM Multispectral Survey Campaign - Status and Initial Mosaics. LPSC XXXVIII, Abstract 2336. Titus, T. N., et al., 2007. MRO CRISM observations of the South Polar Cryptic Region. 7th International Conference on Mars, Abstract 3275.

  14. Root numbers of curves

    Microsoft Academic Search

    MARIA SABITOVA

    2004-01-01

    We generalize a theorem of D. Rohrlich concerning root numbers of elliptic curves over the field of rational numbers. Our result applies to curves of all higher genera over number fields. Namely, under certain conditions which naturally extend the conditions used by D. Rohrlich, we show that the root number associated to a smooth projective curve over a number field

  15. Generating Resources Supply Curves.

    SciTech Connect

    United States. Bonneville Power Administration. Division of Power Resources Planning.

    1985-07-01

    This report documents Pacific Northwest supply curve information for both renewable and other generating resources. Resources are characterized as ''Renewable'' and ''Other'' as defined in section 3 or the Pacific Northwest Electric Power Planning and Conservation Act. The following resources are described: renewable: (cogeneration; geothermal; hydroelectric (new); hydroelectric (efficiency improvement); solar; and wind); other (nonrenewable generation resources: coal; combustion turbines; and nuclear. Each resource has the following information documented in tabular format: (1) Technical Characteristics; (2) Costs (capital and O and M); (3) Energy Distribution by Month; and (4) Supply Forecast (energy). Combustion turbine (CT) energy supply is not forecasted because of CT's typical peaking application. Their supply is therefore unconstrained in order to facilitate analysis of their operation in the regional electrical supply system. The generic nuclear resource is considered unavailable to the region over the planning horizon.

  16. The efficacy of microarray screening for autosomal recessive retinitis pigmentosa in routine clinical practice

    PubMed Central

    van Huet, Ramon A. C.; Pierrache, Laurence H.M.; Meester-Smoor, Magda A.; Klaver, Caroline C.W.; van den Born, L. Ingeborgh; Hoyng, Carel B.; de Wijs, Ilse J.; Collin, Rob W. J.; Hoefsloot, Lies H.

    2015-01-01

    Purpose To determine the efficacy of multiple versions of a commercially available arrayed primer extension (APEX) microarray chip for autosomal recessive retinitis pigmentosa (arRP). Methods We included 250 probands suspected of arRP who were genetically analyzed with the APEX microarray between January 2008 and November 2013. The mode of inheritance had to be autosomal recessive according to the pedigree (including isolated cases). If the microarray identified a heterozygous mutation, we performed Sanger sequencing of exons and exon–intron boundaries of that specific gene. The efficacy of this microarray chip with the additional Sanger sequencing approach was determined by the percentage of patients that received a molecular diagnosis. We also collected data from genetic tests other than the APEX analysis for arRP to provide a detailed description of the molecular diagnoses in our study cohort. Results The APEX microarray chip for arRP identified the molecular diagnosis in 21 (8.5%) of the patients in our cohort. Additional Sanger sequencing yielded a second mutation in 17 patients (6.8%), thereby establishing the molecular diagnosis. In total, 38 patients (15.2%) received a molecular diagnosis after analysis using the microarray and additional Sanger sequencing approach. Further genetic analyses after a negative result of the arRP microarray (n = 107) resulted in a molecular diagnosis of arRP (n = 23), autosomal dominant RP (n = 5), X-linked RP (n = 2), and choroideremia (n = 1). Conclusions The efficacy of the commercially available APEX microarray chips for arRP appears to be low, most likely caused by the limitations of this technique and the genetic and allelic heterogeneity of RP. Diagnostic yields up to 40% have been reported for next-generation sequencing (NGS) techniques that, as expected, thereby outperform targeted APEX analysis. PMID:25999674

  17. A novel HSF4 gene mutation (p.R405X) causing autosomal recessive congenital cataracts in a large consanguineous family from Pakistan

    PubMed Central

    Sajjad, Naheed; Goebel, Ingrid; Kakar, Naseebullah; Cheema, Abdul Majeed; Kubisch, Christian; Ahmad, Jamil

    2008-01-01

    Background Hereditary cataracts are most frequently inherited as autosomal dominant traits, but can also be inherited in an autosomal recessive or X-linked fashion. To date, 12 loci for autosomal recessive cataracts have been mapped including a locus on chromosome 16q22 containing the disease-causing gene HSF4 (Genbank accession number NM_001040667). Here, we describe a family from Pakistan with the first nonsense mutation in HSF4 thus expanding the mutational spectrum of this heat shock transcription factor gene. Methods A large consanguineous Pakistani family with autosomal recessive cataracts was collected from Quetta. Genetic linkage analysis was performed for the common known autosomal recessive cataracts loci and linkage to a locus containing HSF4 (OMIM 602438) was found. All exons and adjacent splice sites of the heat shock transcription factor 4 gene (HSF4) were sequenced. A mutation-specific restriction enzyme digest (HphI) was performed for all family members and unrelated controls. Results The disease phenotype perfectly co-segregated with markers flanking the known cataract gene HSF4, whereas other autosomal recessive loci were excluded. A maximum two-point LOD score with a Zmax = 5.6 at ? = 0 was obtained for D16S421. Direct sequencing of HSF4 revealed the nucleotide exchange c.1213C > T in this family predicting an arginine to stop codon exchange (p.R405X). Conclusion We identified the first nonsense mutation (p.R405X) in exon 11 of HSF4 in a large consanguineous Pakistani family with autosomal recessive cataract. PMID:19014451

  18. Deletions of recessive disease genes: CNV contribution to carrier states and disease-causing alleles

    PubMed Central

    Boone, Philip M.; Campbell, Ian M.; Baggett, Brett C.; Soens, Zachry T.; Rao, Mitchell M.; Hixson, Patricia M.; Patel, Ankita; Bi, Weimin; Cheung, Sau Wai; Lalani, Seema R.; Beaudet, Arthur L.; Stankiewicz, Pawel; Shaw, Chad A.; Lupski, James R.

    2013-01-01

    Over 1200 recessive disease genes have been described in humans. The prevalence, allelic architecture, and per-genome load of pathogenic alleles in these genes remain to be fully elucidated, as does the contribution of DNA copy-number variants (CNVs) to carrier status and recessive disease. We mined CNV data from 21,470 individuals obtained by array-comparative genomic hybridization in a clinical diagnostic setting to identify deletions encompassing or disrupting recessive disease genes. We identified 3212 heterozygous potential carrier deletions affecting 419 unique recessive disease genes. Deletion frequency of these genes ranged from one occurrence to 1.5%. When compared with recessive disease genes never deleted in our cohort, the 419 recessive disease genes affected by at least one carrier deletion were longer and located farther from known dominant disease genes, suggesting that the formation and/or prevalence of carrier CNVs may be affected by both local and adjacent genomic features and by selection. Some subjects had multiple carrier CNVs (307 subjects) and/or carrier deletions encompassing more than one recessive disease gene (206 deletions). Heterozygous deletions spanning multiple recessive disease genes may confer carrier status for multiple single-gene disorders, for complex syndromes resulting from the combination of two or more recessive conditions, or may potentially cause clinical phenotypes due to a multiply heterozygous state. In addition to carrier mutations, we identified homozygous and hemizygous deletions potentially causative for recessive disease. We provide further evidence that CNVs contribute to the allelic architecture of both carrier and recessive disease-causing mutations. Thus, a complete recessive carrier screening method or diagnostic test should detect CNV alleles. PMID:23685542

  19. Relative Locality in Curved Spacetime

    NASA Astrophysics Data System (ADS)

    Kowalski-Glikman, Jerzy; Rosati, Giacomo

    2013-07-01

    In this paper we construct the action describing dynamics of the particle moving in curved spacetime, with a nontrivial momentum space geometry. Curved momentum space is the core feature of theories where relative locality effects are present. So far aspects of nonlinearities in momentum space have been studied only for flat or constantly expanding (de Sitter) spacetimes, relying on their maximally symmetric nature. The extension of curved momentum space frameworks to arbitrary spacetime geometries could be relevant for the opportunities to test Planck-scale curvature/deformation of particles momentum space. As a first example of this construction we describe the particle with ?-Poincaré momentum space on a circular orbit in Schwarzschild spacetime, where the contributes of momentum space curvature turn out to be negligible. The analysis of this problem relies crucially on the solution of the soccer ball problem.

  20. Light Curves of Type IIL Supernovae

    NASA Astrophysics Data System (ADS)

    Richardson, Dean Leon; Benner, Aaron; Babyak, Zachary; Moore, Benjamin John

    2014-06-01

    The absolute-magnitude light curves of 17 Type IIL supernovae are studied. A light curve model is used in the analysis. From the model, we are able to make estimates of the progenitor radius, the kinetic energy in the explosion, the total ejected mass and nickel mass in the explosion as well as the rise time for each supernova.

  1. Detection of outliers in growth curve models

    Microsoft Academic Search

    Madhusudan Bhandary

    1995-01-01

    The growth curve model introduced by Potthoff and Roy (1964) is a general statistical model which includes as special cases regression models and both univariate and multivariate analysis of variance models. In this paper, we discuss procedures for detection of outliers in growth curve models for mean-slippage and dispersion-slippage outlier model. The distributions of the test statistics are discussed and

  2. Gender Differences in Mental Health Outcomes before, during, and after the Great Recession

    PubMed Central

    Dagher, Rada K.; Chen, Jie; Thomas, Stephen B.

    2015-01-01

    We examined gender differences in mental health outcomes during and post-recession versus pre-recession. We utilized 2005-2006, 2008-2009, and 2010-2011 data from the Medical Expenditure Panel Survey. Females had lower odds of depression diagnoses during and post-recession and better mental health during the recession, but higher odds of anxiety diagnoses post-recession. Males had lower odds of depression diagnoses and better mental health during and post-recession and lower Kessler 6 scores post-recession. We conducted stratified analyses, which confirmed that the aforementioned findings were consistent across the four different regions of the U.S., by employment status, income and health care utilization. Importantly, we found that the higher odds of anxiety diagnoses among females after the recession were mainly prominent among specific subgroups of females: those who lived in the Northeast or the Midwest, the unemployed, and those with low household income. Gender differences in mental health in association with the economic recession highlight the importance of policymakers taking these differences into consideration when designing economic and social policies to address economic downturns. Future research should examine the reasons behind the decreased depression diagnoses among both genders, and whether they signify decreased mental healthcare utilization or increased social support and more time for exercise and leisure activities. PMID:25970634

  3. The occultation of Epsilon Geminorum by Mars - Analysis of McDonald data. [turbulent scintillation in light curves

    NASA Technical Reports Server (NTRS)

    Africano, J.; De Vaucouleurs, G.; Evans, D. S.; Finkel, B. E.; Nather, R. E.; Palm, C.; Silverberg, E.; Wiant, J.; Hubbard, W. B.; Jokipii, J. R.

    1977-01-01

    An analysis of observations of the occultation of Epsilon Gem by Mars on April 8, 1976, is presented. The data were obtained by three neighboring telescopes at McDonald Observatory. Intensity fluctuations on time scales of the order of 100 ms were observed simultaneously at the three telescopes. As the observations compare well with predictions of turbulent scintillation theory, it is concluded that such fluctuations were probably largely the effect of stellar scintillations in the Martian atmosphere. The stellar diameter is included as a parameter in the theory but in a way which differs from previously published interpretations of occultations of extended sources by planetary atmospheres. Scintillations govern the experimental uncertainty in the deduction of the scale height of the high Martian atmosphere. A density scale height of 9.9 + or - 2.5 km is obtained at an altitude of 74 + or - 8 km above the mean surface. For CO 2 gas, this result corresponds to a temperature of 190 + or - 50 K.

  4. Evidence of Recessive Alzheimer Disease Loci in a Caribbean Hispanic Data Set

    PubMed Central

    Ghani, Mahdi; Sato, Christine; Lee, Joseph H.; Reitz, Christiane; Moreno, Danielle; Mayeux, Richard; St George-Hyslop, Peter; Rogaeva, Ekaterina

    2014-01-01

    IMPORTANCE The search for novel Alzheimer disease (AD) genes or pathologic mutations within known AD loci is ongoing. The development of array technologies has helped to identify rare recessive mutations among long runs of homozygosity (ROHs), in which both parental alleles are identical. Caribbean Hispanics are known to have an elevated risk for AD and tend to have large families with evidence of inbreeding. OBJECTIVE To test the hypothesis that the late-onset AD in a Caribbean Hispanic population might be explained in part by the homozygosity of unknown loci that could harbor recessive AD risk haplotypes or pathologic mutations. DESIGN We used genome-wide array data to identify ROHs (>1 megabase) and conducted global burden and locus-specific ROH analyses. SETTING A whole-genome case-control ROH study. PARTICIPANTS A Caribbean Hispanic data set of 547 unrelated cases (48.8% with familial AD) and 542 controls collected from a population known to have a 3-fold higher risk of AD vs non-Hispanics in the same community. Based on a Structure program analysis, our data set consisted of African Hispanic (207 cases and 192 controls) and European Hispanic (329 cases and 326 controls) participants. EXPOSURE Alzheimer disease risk genes. MAIN OUTCOMES AND MEASURES We calculated the total and mean lengths of the ROHs per sample. Global burden measurements among autosomal chromosomes were investigated in cases vs controls. Pools of overlapping ROH segments (consensus regions) were identified, and the case to control ratio was calculated for each consensus region. We formulated the tested hypothesis before data collection. RESULTS In total, we identified 17 137 autosomal regions with ROHs. The mean length of the ROH per person was significantly greater in cases vs controls (P = .0039), and this association was stronger with familial AD (P = .0005). Among the European Hispanics, a consensus region at the EXOC4 locus was significantly associated with AD even after correction for multiple testing (empirical P value 1 [EMP1], .0001; EMP2, .002; 21 AD cases vs 2 controls). Among the African Hispanic subset, the most significant but nominal association was observed for CTNNA3, a well-known AD gene candidate (EMP1, .002; 10 AD cases vs 0 controls). CONCLUSIONS AND RELEVANCE Our results show that ROHs could significantly contribute to the etiology of AD. Future studies would require the analysis of larger, relatively inbred data sets that might reveal novel recessive AD genes. The next step is to conduct sequencing of top significant loci in a subset of samples with overlapping ROHs. PMID:23978990

  5. Finding outlier light curves in catalogues of periodic variable stars

    Microsoft Academic Search

    P. Protopapas; J. M. Giammarco; L. Faccioli; M. F. Struble; R. Dave; C. Alcock

    2006-01-01

    We present a methodology to discover outliers in catalogues of periodic light curves. We use a cross-correlation as the measure of `similarity' between two individual light curves, and then classify light curves with lowest average `similarity' as outliers. We performed the analysis on catalogues of periodic variable stars of known type from the MACHO and OGLE projects. This analysis was

  6. Observing the yield curve of compacted pack ice

    Microsoft Academic Search

    Keguang Wang

    2007-01-01

    A method for observing the yield curve of compacted pack ice is developed based on the characteristic analysis of the stress field within the pack ice. The analysis shows that the slope of the yield curve is associated with the angle between intersecting linear kinematic features; thus by measuring the intersection angles we can inversely estimate the yield curve. Applying

  7. Simulation of carbon gasification kinetics using an edge recession model

    SciTech Connect

    Takashi Kyotani; Leon y Leon, C.A.L.; Radovic, L.R. (Pennsylvania State Univ., University Park, PA (United States))

    1993-07-01

    An edge recession modeling method is proposed as a new approach to the prediction of carbon gasification kinetics. Using this method, the variations in reactive surface area (RSA) and specific reactivity (R) with conversion were simulated for several polynuclear aromatic molecules adopted as models of carbon crystallites. The effects of crystallite size and shape, edge site reactivity and vacancies on the changes in RSA and R with conversion were investigated. As a result, RSA and R were found to be essentially independent of crystallite shape, but to depend on crystallite size and the presence of vacancies. Good agreement was obtained between model predictions and experimental data for several kinds of model carbon crystallites. In the case of structurally disordered carbons (such as chars), simultaneous gasification of model crystallites of two different sizes gave better predictions than that of single-size crystallites. The edge recession model is proposed as an alternative, or at least complementary, approach to the more conventional (and, arguably, less physically meaningful) pore structure development models.

  8. A kill curve for Phanerozoic marine species

    NASA Technical Reports Server (NTRS)

    Raup, D. M.

    1991-01-01

    A kill curve for Phanerozoic species is developed from an analysis of the stratigraphic ranges of 17,621 genera, as compiled by Sepkoski. The kill curve shows that a typical species' risk of extinction varies greatly, with most time intervals being characterized by very low risk. The mean extinction rate of 0.25/m.y. is thus a mixture of long periods of negligible extinction and occasional pulses of much higher rate. Because the kill curve is merely a description of the fossil record, it does not speak directly to the causes of extinction. The kill curve may be useful, however, to li inverted question markmit choices of extinction mechanisms.

  9. Reductions in nitrogen oxides over Europe driven by environmental policy and economic recession

    PubMed Central

    Castellanos, Patricia; Boersma, K. Folkert

    2012-01-01

    Fuel combustion is a significant source of numerous air pollutants, which reduce local air quality, and affect global tropospheric chemistry. Satellite observations of nitrogen dioxide, emitted by combustion processes, allow for robust monitoring of atmospheric concentrations at high spatial resolution on continental scales. Here we evaluate changes in tropospheric NO2 concentrations over Europe between 2004 and 2010. We isolate long-term (timescales greater than one year) variability in the daily NO2 observations from the Ozone Monitoring Instrument (OMI) using a spectral analysis. In 2010, we find substantial reductions in NO2 concentrations of at least 20% throughout Europe. These reductions are as much the result of temporary reductions prompted by the 2008–2009 global economic recession, as of European NOx emission controls. Our results demonstrate that realistic concentration pathways of NO2 do not follow simple linear trends, but reflect a compilation of environmental policy and economic activity. PMID:22355777

  10. Friedreich's Ataxia (FRDA) is an extremely rare cause of autosomal recessive ataxia in Chinese Han population.

    PubMed

    Zeng, Junsheng; Wang, Junling; Zeng, Sheng; He, Miao; Zeng, Xianfeng; Zhou, Yao; Liu, Zhen; Jiang, Hong; Tang, Beisha

    2015-04-15

    Friedreich's Ataxia (FRDA) is a very common cause of hereditary autosomal recessive ataxia among western Europeans. We aim to define the frequency of FRDA in Chinese Han population due to the lack of reports of FRDA in China. The GAA trinucleotide repeats in the FXN gene were analyzed by triplet repeat-primed PCR (TP-PCR) in 122 unrelated hereditary ataxia (HA) and 114 unrelated hereditary spastic paraplegia (HSP) patients. The GAA copy numbers in the FXN gene of all the subjects ranged from 5 to 16. There were no FRDA patients that could be diagnosed base on the results of TP-PCR. It suggests that FRDA is a very rare cause of inheritance ataxia and FRDA genetic analysis should not be used as a routine genetic diagnosis test in China. PMID:25765228

  11. Recessive Mutations in COL25A1 Are a Cause of Congenital Cranial Dysinnervation Disorder

    PubMed Central

    Shinwari, Jameela M.A.; Khan, Arif; Awad, Salma; Shinwari, Zakia; Alaiya, Ayodele; Alanazi, Mohamad; Tahir, Asma; Poizat, Coralie; Al Tassan, Nada

    2015-01-01

    Abnormal ocular motility is a common clinical feature in congenital cranial dysinnervation disorder (CCDD). To date, eight genes related to neuronal development have been associated with different CCDD phenotypes. By using linkage analysis, candidate gene screening, and exome sequencing, we identified three mutations in collagen, type XXV, alpha 1 (COL25A1) in individuals with autosomal-recessive inheritance of CCDD ophthalmic phenotypes. These mutations affected either stability or levels of the protein. We further detected altered levels of sAPP (neuronal protein involved in axon guidance and synaptogenesis) and TUBB3 (encoded by TUBB3, which is mutated in CFEOM3) as a result of null mutations in COL25A1. Our data suggest that lack of COL25A1 might interfere with molecular pathways involved in oculomotor neuron development, leading to CCDD phenotypes. PMID:25500261

  12. New Recessive Syndrome of Microcephaly, Cerebellar Hypoplasia, and Congenital Heart Conduction Defect

    PubMed Central

    Zaki, Maha S; Salam, Ghada M H Abdel; Saleem, Sahar N; Dobyns, William B; Issa, Mahmoud Y; Sattar, Shifteh; Gleeson, Joseph G

    2011-01-01

    We identified a two-branch consanguineous family in which four affected members (three females and one male) presented with constitutive growth delay, severe psychomotor retardation, microcephaly, cerebellar hypoplasia, and second-degree heart block. They also shared distinct facial features and similar appearance of their hands and feet. Childhood-onset insulin-dependent diabetes mellitus developed in one affected child around the age of 9 years. Molecular analysis excluded mutations in potentially related genes such as PTF1A, EIF2AK3, EOMES, and WDR62. This condition appears to be unique of other known conditions, suggesting a unique clinical entity of autosomal recessive mode of inheritance. © 2011 Wiley Periodicals, Inc. PMID:22002884

  13. Recessive mutations in COL25A1 are a cause of congenital cranial dysinnervation disorder.

    PubMed

    Shinwari, Jameela M A; Khan, Arif; Awad, Salma; Shinwari, Zakia; Alaiya, Ayodele; Alanazi, Mohamad; Tahir, Asma; Poizat, Coralie; Al Tassan, Nada

    2015-01-01

    Abnormal ocular motility is a common clinical feature in congenital cranial dysinnervation disorder (CCDD). To date, eight genes related to neuronal development have been associated with different CCDD phenotypes. By using linkage analysis, candidate gene screening, and exome sequencing, we identified three mutations in collagen, type XXV, alpha 1 (COL25A1) in individuals with autosomal-recessive inheritance of CCDD ophthalmic phenotypes. These mutations affected either stability or levels of the protein. We further detected altered levels of sAPP (neuronal protein involved in axon guidance and synaptogenesis) and TUBB3 (encoded by TUBB3, which is mutated in CFEOM3) as a result of null mutations in COL25A1. Our data suggest that lack of COL25A1 might interfere with molecular pathways involved in oculomotor neuron development, leading to CCDD phenotypes. PMID:25500261

  14. Whole-Exome Sequencing Identifies Mutated C12orf57 in Recessive Corpus Callosum Hypoplasia

    PubMed Central

    Akizu, Naiara; Shembesh, Nuri M.; Ben-Omran, Tawfeg; Bastaki, Laila; Al-Tawari, Asma; Zaki, Maha S.; Koul, Roshan; Spencer, Emily; Rosti, Rasim Ozgur; Scott, Eric; Nickerson, Elizabeth; Gabriel, Stacey; da Gente, Gilberto; Li, Jiang; Deardorff, Matthew A.; Conlin, Laura K.; Horton, Margaret A.; Zackai, Elaine H.; Sherr, Elliott H.; Gleeson, Joseph G.

    2013-01-01

    The corpus callosum is the principal cerebral commissure connecting the right and left hemispheres. The development of the corpus callosum is under tight genetic control, as demonstrated by abnormalities in its development in more than 1,000 genetic syndromes. We recruited more than 25 families in which members affected with corpus callosum hypoplasia (CCH) lacked syndromic features and had consanguineous parents, suggesting recessive causes. Exome sequence analysis identified C12orf57 mutations at the initiator methionine codon in four different families. C12orf57 is ubiquitously expressed and encodes a poorly annotated 126 amino acid protein of unknown function. This protein is without significant paralogs but has been tightly conserved across evolution. Our data suggest that this conserved gene is required for development of the human corpus callosum. PMID:23453666

  15. Prognostic utility of serum CRP levels in combination with CURB-65 in patients with clinically suspected sepsis: a decision curve analysis

    PubMed Central

    Yamamoto, Shungo; Yamazaki, Shin; Shimizu, Tsunehiro; Takeshima, Taro; Fukuma, Shingo; Yamamoto, Yosuke; Tochitani, Kentaro; Tsuchido, Yasuhiro; Shinohara, Koh; Fukuhara, Shunichi

    2015-01-01

    Objectives The prognostic utility of serum C reactive protein (CRP) alone in sepsis is controversial. We used decision curve analysis (DCA) to evaluate the clinical usefulness of combining serum CRP levels with the CUBR-65 score in patients with suspected sepsis. Design Retrospective cohort study. Setting Emergency department (ED) of an urban teaching hospital in Japan. Participants Consecutive ED patients over 15?years of age who were admitted to the hospital after having a blood culture taken in the ED between 1 January 2010 and 31 December 2012. Main outcome measures 30-day in-hospital mortality. Results Data from 1262 patients were analysed for score evaluation. The 30-day in-hospital mortality was 8.4%. Multivariable analysis showed that serum CRP ?150?mg/L was an independent predictor of death (adjusted OR 2.0; 95% CI 1.3 to 3.1). We compared the predictive performance of CURB-65 with the performance of a modified CURB-65 with that included CRP (?150?mg/L) to quantify the clinical usefulness of combining serum CRP with CURB-65. The areas under the receiver operating characteristics curves of CURB-65 and a modified CURB-65 were 0.76 (95% CI 0.72 to 0.80) and 0.77 (95% CI 0.72 to 0.81), respectively. Both models had good calibration for mortality and were useful among threshold probabilities from 0% to 30%. However, while incorporating CRP into CURB-65 yielded a significant category-free net reclassification improvement of 0.387 (95% CI 0.193 to 0.582) and integrated discrimination improvement of 0.015 (95% CI 0.004 to 0.027), DCA showed that CURB-65 and the modified CURB-65 score had comparable net benefits for prediction of mortality. Conclusions Measurement of serum CRP added limited clinical usefulness to CURB-65 in predicting mortality in patients with clinically suspected sepsis, regardless of the source. PMID:25922102

  16. Physical Activity During Recess Outdoors and Indoors Among Urban Public School Students, St. Louis, Missouri, 2010–2011

    PubMed Central

    Tran, Irene; Clark, B. Ruth

    2013-01-01

    We measured the quantity and intensity of physical activity in 106 urban public school students during recess outdoors, recess indoors in the gym, and recess indoors in the classroom. Students in grades 2 through 5 wore accelerometer pedometers for an average of 6.2 (standard deviation [SD], 1.4) recess periods over 8 weeks; a subsample of 26 also wore heart rate monitors. We determined, on the basis of 655 recess observations, that outdoor recess enabled more total steps per recess period (P < .0001), more steps in moderate-to-vigorous physical activity (P < .0001), and higher heart rates than recess in the gym or classroom. To maximize physical activity quantity and intensity, school policies should promote outdoor recess. PMID:24262028

  17. Bayesian bootstrap estimation of ROC curve.

    PubMed

    Gu, Jiezhun; Ghosal, Subhashis; Roy, Anindya

    2008-11-20

    Receiver operating characteristic (ROC) curve is widely applied in measuring discriminatory ability of diagnostic or prognostic tests. This makes the ROC analysis one of the most active research areas in medical statistics. Many parametric and semiparametric estimation methods have been proposed for estimating the ROC curve and its functionals. In this paper, we propose the Bayesian bootstrap (BB), a fully nonparametric estimation method, for the ROC curve and its functionals, such as the area under the curve (AUC). The BB method offers a bandwidth-free smoothing approach to the empirical estimate, and gives credible bounds. The accuracy of the estimate of the ROC curve in the simulation studies is examined by the integrated absolute error. In comparison with other existing curve estimation methods, the BB method performs well in terms of accuracy, robustness and simplicity. We also propose a procedure based on the BB approach to test the binormality assumption. PMID:18613217

  18. Melting curve analysis of a groEL PCR fragment for the rapid genotyping of strains belonging to the Lactobacillus casei group of species.

    PubMed

    Koirala, Ranjan; Taverniti, Valentina; Balzaretti, Silvia; Ricci, Giovanni; Fortina, Maria Grazia; Guglielmetti, Simone

    2015-04-01

    Lactobacillus casei group (Lcs) consists of three phylogenetically closely related species (L. casei, L. paracasei, and L. rhamnosus), which are widely used in the dairy and probiotic industrial sectors. Strategies to easily and rapidly characterize Lcs are therefore of interest. To this aim, we developed a method according to a technique known as high resolution melting analysis (HRMa), which was applied to a 150 bp groEL gene fragment. The analysis was performed on 53 Lcs strains and 29 strains representatives of species that are commonly present in dairy and probiotic products and can be most probably co-isolated with Lcs strains. DNA amplification was obtained only from Lcs strains, demonstrating the specificity of the groEL primers designed in this study. The HRMa clustered Lcs strains in three groups that exactly corresponded to the species of the L. casei group. A following HRMa separated the 39 L. paracasei strains in two well distinct intraspecific groups, indicating the possible existence of at least two distinct genotypes inside the species. Nonetheless, the phenotypic characterization demonstrated that the genotypes do not correspond to the two L. paracasei subspecies, namely paracasei and tolerans. In conclusion, the melting curve analysis developed in this study is demonstrably a simple, labor-saving, and rapid strategy obtain the genotyping of a bacterial isolate and simultaneously potentially confirm its affiliation to the L. casei group of species. The application of this method to a larger collection of strains may validate the possibility to use the proposed HRMa protocol for the taxonomic discrimination of L. casei group of species. In general, this study suggests that HRMa can be a suitable technique for the genetic typization of Lactobacillus strains. PMID:25801971

  19. Automated Forensic Animal Family Identification by Nested PCR and Melt Curve Analysis on an Off-the-Shelf Thermocycler Augmented with a Centrifugal Microfluidic Disk Segment

    PubMed Central

    Zengerle, Roland; von Stetten, Felix; Schmidt, Ulrike

    2015-01-01

    Nested PCR remains a labor-intensive and error-prone biomolecular analysis. Laboratory workflow automation by precise control of minute liquid volumes in centrifugal microfluidic Lab-on-a-Chip systems holds great potential for such applications. However, the majority of these systems require costly custom-made processing devices. Our idea is to augment a standard laboratory device, here a centrifugal real-time PCR thermocycler, with inbuilt liquid handling capabilities for automation. We have developed a microfluidic disk segment enabling an automated nested real-time PCR assay for identification of common European animal groups adapted to forensic standards. For the first time we utilize a novel combination of fluidic elements, including pre-storage of reagents, to automate the assay at constant rotational frequency of an off-the-shelf thermocycler. It provides a universal duplex pre-amplification of short fragments of the mitochondrial 12S rRNA and cytochrome b genes, animal-group-specific main-amplifications, and melting curve analysis for differentiation. The system was characterized with respect to assay sensitivity, specificity, risk of cross-contamination, and detection of minor components in mixtures. 92.2% of the performed tests were recognized as fluidically failure-free sample handling and used for evaluation. Altogether, augmentation of the standard real-time thermocycler with a self-contained centrifugal microfluidic disk segment resulted in an accelerated and automated analysis reducing hands-on time, and circumventing the risk of contamination associated with regular nested PCR protocols. PMID:26147196

  20. Recessive Mutations in SPTBN2 Implicate ?-III Spectrin in Both Cognitive and Motor Development

    PubMed Central

    Kwasniewska, Alexandra; Sadighi Akha, Elham; Parolin Schnekenberg, Ricardo; Suminaite, Daumante; Hope, Jilly; Baker, Ian; Gregory, Lorna; Green, Angie; Allan, Chris; Lamble, Sarah; Jayawant, Sandeep; Quaghebeur, Gerardine; Cader, M. Zameel; Hughes, Sarah; Armstrong, Richard J. E.; Kanapin, Alexander; Rimmer, Andrew; Lunter, Gerton; Mathieson, Iain; Cazier, Jean-Baptiste; Buck, David; Taylor, Jenny C.; Bentley, David; McVean, Gilean; Donnelly, Peter; Knight, Samantha J. L.; Jackson, Mandy; Ragoussis, Jiannis; Németh, Andrea H.

    2012-01-01

    ?-III spectrin is present in the brain and is known to be important in the function of the cerebellum. Heterozygous mutations in SPTBN2, the gene encoding ?-III spectrin, cause Spinocerebellar Ataxia Type 5 (SCA5), an adult-onset, slowly progressive, autosomal-dominant pure cerebellar ataxia. SCA5 is sometimes known as “Lincoln ataxia,” because the largest known family is descended from relatives of the United States President Abraham Lincoln. Using targeted capture and next-generation sequencing, we identified a homozygous stop codon in SPTBN2 in a consanguineous family in which childhood developmental ataxia co-segregates with cognitive impairment. The cognitive impairment could result from mutations in a second gene, but further analysis using whole-genome sequencing combined with SNP array analysis did not reveal any evidence of other mutations. We also examined a mouse knockout of ?-III spectrin in which ataxia and progressive degeneration of cerebellar Purkinje cells has been previously reported and found morphological abnormalities in neurons from prefrontal cortex and deficits in object recognition tasks, consistent with the human cognitive phenotype. These data provide the first evidence that ?-III spectrin plays an important role in cortical brain development and cognition, in addition to its function in the cerebellum; and we conclude that cognitive impairment is an integral part of this novel recessive ataxic syndrome, Spectrin-associated Autosomal Recessive Cerebellar Ataxia type 1 (SPARCA1). In addition, the identification of SPARCA1 and normal heterozygous carriers of the stop codon in SPTBN2 provides insights into the mechanism of molecular dominance in SCA5 and demonstrates that the cell-specific repertoire of spectrin subunits underlies a novel group of disorders, the neuronal spectrinopathies, which includes SCA5, SPARCA1, and a form of West syndrome. PMID:23236289

  1. Recessive mutations in SPTBN2 implicate ?-III spectrin in both cognitive and motor development.

    PubMed

    Lise, Stefano; Clarkson, Yvonne; Perkins, Emma; Kwasniewska, Alexandra; Sadighi Akha, Elham; Schnekenberg, Ricardo Parolin; Suminaite, Daumante; Hope, Jilly; Baker, Ian; Gregory, Lorna; Green, Angie; Allan, Chris; Lamble, Sarah; Jayawant, Sandeep; Quaghebeur, Gerardine; Cader, M Zameel; Hughes, Sarah; Armstrong, Richard J E; Kanapin, Alexander; Rimmer, Andrew; Lunter, Gerton; Mathieson, Iain; Cazier, Jean-Baptiste; Buck, David; Taylor, Jenny C; Bentley, David; McVean, Gilean; Donnelly, Peter; Knight, Samantha J L; Jackson, Mandy; Ragoussis, Jiannis; Németh, Andrea H

    2012-01-01

    ?-III spectrin is present in the brain and is known to be important in the function of the cerebellum. Heterozygous mutations in SPTBN2, the gene encoding ?-III spectrin, cause Spinocerebellar Ataxia Type 5 (SCA5), an adult-onset, slowly progressive, autosomal-dominant pure cerebellar ataxia. SCA5 is sometimes known as "Lincoln ataxia," because the largest known family is descended from relatives of the United States President Abraham Lincoln. Using targeted capture and next-generation sequencing, we identified a homozygous stop codon in SPTBN2 in a consanguineous family in which childhood developmental ataxia co-segregates with cognitive impairment. The cognitive impairment could result from mutations in a second gene, but further analysis using whole-genome sequencing combined with SNP array analysis did not reveal any evidence of other mutations. We also examined a mouse knockout of ?-III spectrin in which ataxia and progressive degeneration of cerebellar Purkinje cells has been previously reported and found morphological abnormalities in neurons from prefrontal cortex and deficits in object recognition tasks, consistent with the human cognitive phenotype. These data provide the first evidence that ?-III spectrin plays an important role in cortical brain development and cognition, in addition to its function in the cerebellum; and we conclude that cognitive impairment is an integral part of this novel recessive ataxic syndrome, Spectrin-associated Autosomal Recessive Cerebellar Ataxia type 1 (SPARCA1). In addition, the identification of SPARCA1 and normal heterozygous carriers of the stop codon in SPTBN2 provides insights into the mechanism of molecular dominance in SCA5 and demonstrates that the cell-specific repertoire of spectrin subunits underlies a novel group of disorders, the neuronal spectrinopathies, which includes SCA5, SPARCA1, and a form of West syndrome. PMID:23236289

  2. Production of F 1 and F 2 diploid gynogenetic tilapias and analysis of the “Hertwig curve” obtained using ultraviolet irradiated sperm

    Microsoft Academic Search

    J. Don; R. R. Avtalion

    1988-01-01

    In this study, a Hertwig effect with a non-typical biphasic curve was obtained using sperm irradiated with increasing intensities of UV. The first phase of the UV curve appeared to be quite different from that normally demonstrated using ? or x-ray irradiation. This difference is characterised throughout the length of the first phase by (1) low and stable embryo hatching

  3. Analytical model for flow duration curves in seasonally dry climates

    NASA Astrophysics Data System (ADS)

    Müller, Marc F.; Dralle, David N.; Thompson, Sally E.

    2014-07-01

    Flow duration curves (FDC) display streamflow values against their relative exceedance time. They provide critical information for watershed management by representing the variation in the availability and reliability of surface water to supply ecosystem services and satisfy anthropogenic needs. FDCs are particularly revealing in seasonally dry climates, where surface water supplies are highly variable. While useful, the empirical computation of FDCs is data intensive and challenging in sparsely gauged regions, meaning that there is a need for robust, predictive models to evaluate FDCs with simple parameterization. Here, we derive a process-based analytical expression for FDCs in seasonally dry climates. During the wet season, streamflow is modeled as a stochastic variable driven by rainfall, following the stochastic analytical model of Botter et al. (2007a). During the dry season, streamflow is modeled as a deterministic recession with a stochastic initial condition that accounts for the carryover of catchment storage across seasons. The resulting FDC model is applied to 38 catchments in Nepal, coastal California, and Western Australia, where FDCs are successfully modeled using five physically meaningful parameters with minimal calibration. A Monte Carlo analysis revealed that the model is robust to deviations from its assumptions of Poissonian rainfall, exponentially distributed response times and constant seasonal timing. The approach successfully models period-of-record FDCs and allows interannual and intra-annual sources of variations in dry season streamflow to be separated. The resulting median annual FDCs and confidence intervals allow the simulation of the consequences of interannual flow variations for infrastructure projects. We present an example using run-of-river hydropower in Nepal as a case study.

  4. Fluorescence melting curve analysis using self-quenching dual-labeled peptide nucleic acid probes for simultaneously identifying multiple DNA sequences.

    PubMed

    Ahn, Jeong Jin; Kim, Youngjoo; Lee, Seung Yong; Hong, Ji Young; Kim, Gi Won; Hwang, Seung Yong

    2015-09-01

    Previous fluorescence melting curve analysis (FMCA) used intercalating dyes, and this method has restricted application. Therefore, FMCA methods such as probe-based FMCA and molecular beacons were studied. However, the usual dual-labeled probes do not possess adequate fluorescence quenching ability and sufficient specificity, and molecular beacons with the necessary stem structures are hard to design. Therefore, we have developed a peptide nucleic acid (PNA)-based FMCA method. PNA oligonucleotide can have a much higher melting temperature (Tm) value than DNA. Therefore, short PNA probes can have adequate Tm values for FMCA, and short probes can have higher specificity and accuracy in FMCA. Moreover, dual-labeled PNA probes have self-quenching ability via single-strand base stacking, which makes PNA more favorable. In addition, this method can facilitate simultaneous identification of multiple DNA templates. In conventional real-time polymerase chain reaction (PCR), one fluorescence channel can identify only one DNA template. However, this method uses two fluorescence channels to detect three types of DNA. Experiments were performed with one to three different DNA sequences mixed in a single tube. This method can be used to identify multiple DNA sequences in a single tube with high specificity and high clarity. PMID:26049100

  5. Detection of BRAF V600E activating mutation in papillary thyroid carcinoma using PCR with allele?specific fluorescent probe melting curve analysis

    PubMed Central

    Rowe, Leslie R; Bentz, Brandon G; Bentz, Joel S

    2007-01-01

    Background A single hotspot mutation at nucleotide 1799 of the BRAF gene has been identified as the most common genetic event in papillary thyroid carcinoma (PTC), with a prevalence of 29–83%. Aims To use a PCR assay to molecularly characterise the BRAF activating point mutation in a series of PTC and benign thyroid cases and correlate the mutation results with histological findings. Methods Formalin?fixed paraffin?embedded (FFPE) sections were evaluated for the BRAF V600E mutation using LightCycler PCR with allele?specific fluorescent probe melting curve analysis (LCPCR). Results 42 (37 PTC; 5 benign) surgical tissue samples were analysed for the BRAF V600E activating point mutation. Using LCPCR and direct DNA sequencing, the BRAF mutation was identified in 23/37 (62.2%) PTC FFPE samples. DNA sequencing results demonstrated confirmation of the mutation. Conclusions Detection of BRAF?activating mutations in PTC suggests new approaches to management and treatment of this disease that may prove worthwhile. Identification of the BRAF V600E activating mutation in routine FFPE pathology samples by a rapid laboratory method such as LCPCR could have significant value. PMID:17298986

  6. Application of a qPCR Assay with Melting Curve Analysis for Detection and Differentiation of Protozoan Oocysts in Human Fecal Samples from Dominican Republic

    PubMed Central

    Lalonde, Laura F.; Reyes, Julissa; Gajadhar, Alvin A.

    2013-01-01

    A quantitative polymerase chain reaction assay with melt curve analysis (qPCR-MCA) was applied for the detection of protozoan oocysts in 501 human fecal samples collected in Dominican Republic. Samples were subjected to qPCR using universal coccidia primers targeting 18S rDNA to detect oocysts followed by MCA to identify oocyst species based on amplicon melting temperature. Putative positive samples were also tested by conventional PCR and microscopy. Cystoisospora belli (×3), Cryptosporidium parvum (×3), Cryptosporidium hominis (×5), Cryptosporidium meleagridis (×1), Cryptosporidium canis (×1), and Cyclospora cayetanensis (×9) were detected by qPCR-MCA and confirmed by sequencing. This assay consistently detected 10 copies of the cloned target fragment and can be considered more efficient and sensitive than microscopy flotation methods for detecting multiple species of oocysts in human feces. The qPCR-MCA is a reliable protozoan oocyst screening assay for use on clinical and environmental samples in public health, food safety and veterinary programs. PMID:24019437

  7. Application of a qPCR assay with melting curve analysis for detection and differentiation of protozoan oocysts in human fecal samples from Dominican Republic.

    PubMed

    Lalonde, Laura F; Reyes, Julissa; Gajadhar, Alvin A

    2013-11-01

    A quantitative polymerase chain reaction assay with melt curve analysis (qPCR-MCA) was applied for the detection of protozoan oocysts in 501 human fecal samples collected in Dominican Republic. Samples were subjected to qPCR using universal coccidia primers targeting 18S rDNA to detect oocysts followed by MCA to identify oocyst species based on amplicon melting temperature. Putative positive samples were also tested by conventional PCR and microscopy. Cystoisospora belli (×3), Cryptosporidium parvum (×3), Cryptosporidium hominis (×5), Cryptosporidium meleagridis (×1), Cryptosporidium canis (×1), and Cyclospora cayetanensis (×9) were detected by qPCR-MCA and confirmed by sequencing. This assay consistently detected 10 copies of the cloned target fragment and can be considered more efficient and sensitive than microscopy flotation methods for detecting multiple species of oocysts in human feces. The qPCR-MCA is a reliable protozoan oocyst screening assay for use on clinical and environmental samples in public health, food safety and veterinary programs. PMID:24019437

  8. Hierarchical Bayesian analysis to incorporate age uncertainty in growth curve analysis and estimates of age from length: Florida manatee (Trichechus manatus) carcasses

    USGS Publications Warehouse

    Schwarz, L.K.; Runge, M.C.

    2009-01-01

    Age estimation of individuals is often an integral part of species management research, and a number of ageestimation techniques are commonly employed. Often, the error in these techniques is not quantified or accounted for in other analyses, particularly in growth curve models used to describe physiological responses to environment and human impacts. Also, noninvasive, quick, and inexpensive methods to estimate age are needed. This research aims to provide two Bayesian methods to (i) incorporate age uncertainty into an age-length Schnute growth model and (ii) produce a method from the growth model to estimate age from length. The methods are then employed for Florida manatee (Trichechus manatus) carcasses. After quantifying the uncertainty in the aging technique (counts of ear bone growth layers), we fit age-length data to the Schnute growth model separately by sex and season. Independent prior information about population age structure and the results of the Schnute model are then combined to estimate age from length. Results describing the age-length relationship agree with our understanding of manatee biology. The new methods allow us to estimate age, with quantified uncertainty, for 98% of collected carcasses: 36% from ear bones, 62% from length.

  9. The Nuclear Zone of a Leimkuhler Curve.

    ERIC Educational Resources Information Center

    Rousseau, Ronald

    1987-01-01

    Proposes a new definition of the nuclear zone of a Bradford or Leimkuhler curve. The mathematical rationale is outlined, and examples of the application of this technique to citation analysis are given. (15 references) (CLB)

  10. SMOOTHING SPLINE GROWTH CURVES WITH COVARIATES

    E-print Network

    ; 2 is replaced by its unbiased esti- mate. #3; Permanent address: College of Staten Island, C.U.N.Y., Staten Island 1 #12; I. INTRODUCTION Growth curve analysis is used to parameterize a family of temporal

  11. Are Driving and Overtaking on Right Curves More Dangerous than on Left Curves?

    PubMed Central

    Othman, Sarbaz; Thomson, Robert; Lannér, Gunnar

    2010-01-01

    It is well known that crashes on horizontal curves are a cause for concern in all countries due to the frequency and severity of crashes at curves compared to road tangents. A recent study of crashes in western Sweden reported a higher rate of crashes in right curves than left curves. To further understand this result, this paper reports the results of novel analyses of the responses of vehicles and drivers during negotiating and overtaking maneuvers on curves for right hand traffic. The overall objectives of the study were to find road parameters for curves that affect vehicle dynamic responses, to analyze these responses during overtaking maneuvers on curves, and to link the results with driver behavior for different curve directions. The studied road features were speed, super-elevation, radius and friction including their interactions, while the analyzed vehicle dynamic factors were lateral acceleration and yaw angular velocity. A simulation program, PC-Crash, has been used to simulate road parameters and vehicle response interaction in curves. Overtaking maneuvers have been simulated for all road feature combinations in a total of 108 runs. Analysis of variances (ANOVA) was performed, using two sided randomized block design, to find differences in vehicle responses for the curve parameters. To study driver response, a field test using an instrumented vehicle and 32 participants was reviewed as it contained longitudinal speed and acceleration data for analysis. The simulation results showed that road features affect overtaking performance in right and left curves differently. Overtaking on right curves was sensitive to radius and the interaction of radius with road condition; while overtaking on left curves was more sensitive to super-elevation. Comparisons of lateral acceleration and yaw angular velocity during these maneuvers showed different vehicle response configurations depending on curve direction and maneuver path. The field test experiments also showed that drivers behave differently depending on the curve direction where both speed and acceleration were higher on right than left curves. The implication of this study is that curve direction should be taken into consideration to a greater extent when designing and redesigning curves. It appears that the driver and the vehicle are influenced by different infrastructure factors depending on the curve direction. In addition, the results suggest that the vehicle dynamics response alone cannot explain the higher crash risk in right curves. Further studies of the links between driver, vehicle, and highway characteristics are needed, such as naturalistic driving studies, to identify the key safety indicators for highway safety. PMID:21050608

  12. Are driving and overtaking on right curves more dangerous than on left curves?

    PubMed

    Othman, Sarbaz; Thomson, Robert; Lannér, Gunnar

    2010-01-01

    It is well known that crashes on horizontal curves are a cause for concern in all countries due to the frequency and severity of crashes at curves compared to road tangents. A recent study of crashes in western Sweden reported a higher rate of crashes in right curves than left curves. To further understand this result, this paper reports the results of novel analyses of the responses of vehicles and drivers during negotiating and overtaking maneuvers on curves for right hand traffic. The overall objectives of the study were to find road parameters for curves that affect vehicle dynamic responses, to analyze these responses during overtaking maneuvers on curves, and to link the results with driver behavior for different curve directions. The studied road features were speed, super-elevation, radius and friction including their interactions, while the analyzed vehicle dynamic factors were lateral acceleration and yaw angular velocity. A simulation program, PC-Crash, has been used to simulate road parameters and vehicle response interaction in curves. Overtaking maneuvers have been simulated for all road feature combinations in a total of 108 runs. Analysis of variances (ANOVA) was performed, using two sided randomized block design, to find differences in vehicle responses for the curve parameters. To study driver response, a field test using an instrumented vehicle and 32 participants was reviewed as it contained longitudinal speed and acceleration data for analysis. The simulation results showed that road features affect overtaking performance in right and left curves differently. Overtaking on right curves was sensitive to radius and the interaction of radius with road condition; while overtaking on left curves was more sensitive to super-elevation. Comparisons of lateral acceleration and yaw angular velocity during these maneuvers showed different vehicle response configurations depending on curve direction and maneuver path. The field test experiments also showed that drivers behave differently depending on the curve direction where both speed and acceleration were higher on right than left curves. The implication of this study is that curve direction should be taken into consideration to a greater extent when designing and redesigning curves. It appears that the driver and the vehicle are influenced by different infrastructure factors depending on the curve direction. In addition, the results suggest that the vehicle dynamics response alone cannot explain the higher crash risk in right curves. Further studies of the links between driver, vehicle, and highway characteristics are needed, such as naturalistic driving studies, to identify the key safety indicators for highway safety. PMID:21050608

  13. Playground Designs to Increase Physical Activity Levels during School Recess: A Systematic Review

    ERIC Educational Resources Information Center

    Escalante, Yolanda; García-Hermoso, Antonio; Backx, Karianne; Saavedra, Jose M.

    2014-01-01

    School recess provides a major opportunity to increase children's physical activity levels. Various studies have described strategies to increase levels of physical activity. The purpose of this systematic review is therefore to examine the interventions proposed as forms of increasing children's physical activity levels during recess. A…

  14. Recess in Elementary School: What Does the Research Say? ERIC Digest.

    ERIC Educational Resources Information Center

    Jarrett, Olga S.

    Compared to the rest of the school day, recess is a time when children have more freedom to choose what they want to do and with whom. In light of the current climate of school accountability, this digest discusses research on recess and its relationship to learning, social development, and child health, as well as research on related topics that…

  15. A fascination with chromosome rescue in uniparental disomy: Mendelian recessive outlaws and imprinting copyrights infringements

    Microsoft Academic Search

    Eric Engel

    2006-01-01

    With uniparental disomy (UPD), the presence in a diploid genome of a chromosome pair derived from one genitor carries two main types of developmental risk: the inheritance of a recessive trait or the occurrence of an imprinting disorder. When the uniparentally derived pair carries two homozygous sequences (isodisomy) with a duplicated mutant, this ‘reduction to homozygosity’ determines a recessive phenotype

  16. The Recess Period: A Key Moment of Prepubescent Children's Daily Physical Activity?

    ERIC Educational Resources Information Center

    Guinhouya, Comlavi B.; Hubert, Herve; Dupont, Gregory; Durocher, Alain

    2005-01-01

    This study was designed to analyze the significance of the recess period and "the effect of its duration" on children's daily physical activity. Thirteen pupils attending school in a rural area were monitored with accelerometers during the study weeks. The intervention consisted of modifying regularly scheduled recess period for a month. Data from…

  17. Understanding the cellular and molecular mechanisms of dominant and recessive inheritance in genetics course.

    PubMed

    Wanjin, Xing; Morigen, Morigen

    2015-01-01

    In Mendellian genetics, the dominance and recessiveness are used to describe the functional relationship between two alleles of one gene in a heterozygote. The allele which constitutes a phenotypical character over the other is named dominant and the one functionally masked is called recessive. The definitions thereby led to the creation of Mendel's laws on segregation and independent assortment and subsequent classic genetics. The discrimination of dominance and recessiveness originally is a requirement for Mendel's logical reasoning, but now it should be explained by cellular and molecular principles in the modern genetics. To answer the question raised by students of how the dominance and recessiveness are controlled, we reviewed the recent articles and tried to summarize the cellular and molecular basis of dominant and recessive inheritance. Clearly, understanding the essences of dominant and recessive inheritance requires us to know the dissimilarity of the alleles and their products (RNA and/or proteins), and the way of their function in cells. The alleles spatio-temporally play different roles on offering cells, tissues or organs with discernible phenotypes, namely dominant or recessive. Here, we discuss the changes of allele dominance and recessiveness at the cellular and molecular levels based on the variation of gene structure, gene regulation, function and types of gene products, in order to make students understand gene mutation and function more comprehensively and concretely. PMID:25608820

  18. The contribution of preschool playground factors in explaining children's physical activity during recess

    Microsoft Academic Search

    Greet Cardon; Eveline Van Cauwenberghe; Valery Labarque; Leen Haerens; Ilse De Bourdeaudhuij

    2008-01-01

    BACKGROUND: Low levels of physical activity are characteristic in preschoolers. To effectively promote physical activity, it is necessary to understand factors that influence young children's physical activity. The present study aimed to investigate how physical activity levels are influenced by environmental factors during recess in preschool. METHODS: Preschool playground observations and pedometry during recess were carried out in 39 randomly

  19. Recess before Lunch Programs in Elementary Schools: Perceptions and Practices of School Professionals

    ERIC Educational Resources Information Center

    Bounds, Wendy; Nettles, Mary Frances; Johnson, James T.

    2009-01-01

    Purpose/Objectives: The objectives of this study were to examine the perceptions of school nutrition directors, principals/assistant principals, and teachers regarding issues important to consider when scheduling recess in relation to lunch, and to describe practices related to successfully implementing a recess before lunch program. Methods: A…

  20. A Screen for Recessive Speciation Genes Expressed in the Gametes of F1 Hybrid Yeast

    E-print Network

    Nachman, Michael

    A Screen for Recessive Speciation Genes Expressed in the Gametes of F1 Hybrid Yeast Duncan Greig not play a major role in yeast speciation. Citation: Greig D (2007) A screen for recessive speciation genes expressed in the gametes of F1 hybrid yeast. PLoS Genet 3(2): e21. doi:10.1371/journal.pgen.0030021