Sample records for recession curve analysis

  1. Regionalization of subsurface stormflow parameters of hydrologic models: Derivation from regional analysis of streamflow recession curves

    SciTech Connect

    Ye, Sheng; Li, Hongyi; Huang, Maoyi; Ali, Melkamu; Leng, Guoyong; Leung, Lai-Yung R.; Wang, Shaowen; Sivapalan, Murugesu

    2014-07-21

    Subsurface stormflow is an important component of the rainfall–runoff response, especially in steep terrain. Its contribution to total runoff is, however, poorly represented in the current generation of land surface models. The lack of physical basis of these common parameterizations precludes a priori estimation of the stormflow (i.e. without calibration), which is a major drawback for prediction in ungauged basins, or for use in global land surface models. This paper is aimed at deriving regionalized parameterizations of the storage–discharge relationship relating to subsurface stormflow from a top–down empirical data analysis of streamflow recession curves extracted from 50 eastern United States catchments. Detailed regression analyses were performed between parameters of the empirical storage–discharge relationships and the controlling climate, soil and topographic characteristics. The regression analyses performed on empirical recession curves at catchment scale indicated that the coefficient of the power-law form storage–discharge relationship is closely related to the catchment hydrologic characteristics, which is consistent with the hydraulic theory derived mainly at the hillslope scale. As for the exponent, besides the role of field scale soil hydraulic properties as suggested by hydraulic theory, it is found to be more strongly affected by climate (aridity) at the catchment scale. At a fundamental level these results point to the need for more detailed exploration of the co-dependence of soil, vegetation and topography with climate.

  2. Regionalization of subsurface stormflow parameters of hydrologic models: Derivation from regional analysis of streamflow recession curves

    NASA Astrophysics Data System (ADS)

    Ye, Sheng; Li, Hong-Yi; Huang, Maoyi; Ali, Melkamu; Leng, Guoyong; Leung, L. Ruby; Wang, Shao-wen; Sivapalan, Murugesu

    2014-11-01

    Subsurface stormflow is an important component of the rainfall-runoff response, especially in steep terrain. Its contribution to total runoff is, however, poorly represented in the current generation of land surface models. The lack of physical basis of these common parameterizations precludes a priori estimation of the stormflow (i.e. without calibration), which is a major drawback for prediction in ungauged basins, or for use in global land surface models. This paper is aimed at deriving regionalized parameterizations of the storage-discharge relationship relating to subsurface stormflow from a top-down empirical data analysis of streamflow recession curves extracted from 50 eastern United States catchments. Detailed regression analyses were performed between parameters of the empirical storage-discharge relationships and the controlling climate, soil and topographic characteristics. The regression analyses performed on empirical recession curves at catchment scale indicated that the coefficient of the power-law form storage-discharge relationship is closely related to the catchment hydrologic characteristics, which is consistent with the hydraulic theory derived mainly at the hillslope scale. As for the exponent, besides the role of field scale soil hydraulic properties as suggested by hydraulic theory, it is found to be more strongly affected by climate (aridity) at the catchment scale. At a fundamental level these results point to the need for more detailed exploration of the co-dependence of soil, vegetation and topography with climate.

  3. Geomorphological origin of recession curves

    NASA Astrophysics Data System (ADS)

    Biswal, Basudev; Marani, Marco

    2010-12-01

    We identify a previously undetected link between the river network morphology and key recession curves properties through a conceptual-physical model of the drainage process of the riparian unconfined aquifer. We show that the power-law exponent, ?, of -dQ/dt vs. Q curves is related to the power-law exponent of N(l) vs. G(l) curves (which we show to be connected to Hack's law), where l is the downstream distance from the channel heads, N(l) is the number of channel reaches exactly located at a distance l from their channel head, and G(l) is the total length of the network located at a distance greater or equal to l from channel heads. Using Digital Terrain Models and daily discharge observations from 67 US basins we find that geomorphologic ? estimates match well the values obtained from recession curves analyses. Finally, we argue that the link between recession flows and network morphology points to an important role of low-flow discharges in shaping the channel network.

  4. ‘Universal’ recession curves and their geomorphological interpretation

    NASA Astrophysics Data System (ADS)

    Biswal, Basudev; Marani, Marco

    2014-03-01

    The study of recession flows offers fundamental insights into basin hydrological processes and, in particular, into the collective behavior of the governing dominant subsurface flows and properties. We use here an existing geomorphological interpretation of recession dynamics, which links the exponent in the classic recession curve -dQ/dt=kQ? to the geometric properties of the time-varying drainage network to study the general properties of recession curves across a wide variety of river basins. In particular, we show how the parameter k depends on the initial soil moisture state of the basin and can be made to explicitly depend on an index discharge, representative of initial sub-subsurface storage. Through this framework we obtain a non-dimensional, event-independent, recession curve. We subsequently quantify the variability of k across different basins on the basis of their geometry, and, by rescaling, collapse curves from different events and basins to obtain a generalized, or ‘universal’, recession curve. Finally, we analyze the resulting normalized recession curves and explain their universal characteristics, lending further support to the notion that the statistical properties of observed recession curves bear the signature of the geomorphological structure of the networks producing them.

  5. "Universal" Recession Curves and their Geomorphological Roots

    NASA Astrophysics Data System (ADS)

    Marani, M.; Biswal, B.

    2011-12-01

    The basic structural organization of channel networks, and of the connected hillslopes, have been shown to be intimately linked to basin responses to rainfall events, leading to geomorphological theories of the hydrologic response. Here, We identify a previously undetected link between the river network morphology and key recession curves properties. We show that the power-law exponent of -dQ/dt vs. Q curves is related to the power-law exponent of N(l) vs. G(l) curves (which we show to be connected to Hack's law), where l is the downstream distance from the channel heads, N(l) is the number of channel reaches exactly located at a distance l from their channel head, and G(l) is the total length of the network located at a distance greater or equal to l from channel heads. We then generalize the power-law expressions of recession curves, to identify "universal" curves, independent of the initial moisture conditions and of basin area, by making the -dQ/dt vs. Q curve non-dimensional using an index discharge representative of initial moisture conditions. We subsequently rescale the geomorphic recession curve, N(l) vs. G(l), producing a collapse of the geomorphic recession curves constructed from the DTM's of 67 US study basins. Finally, by use of the specific discharge u = Q/A, we link the two previous results and define the specific recession curves, whose collapse across basins within homogeneous geographical areas lends further, decisive, support to the notion that the statistical properties of observational recession curves bear the signature of the geomorphological structure of the networks producing them.

  6. An improved method for delineating source protection zones for karst springs based on analysis of recession curve data

    NASA Astrophysics Data System (ADS)

    Civita, Massimo V.

    2008-08-01

    A standard method for delineating source protection zones, particularly for karst and carbonate springs, has been improved. The method, based on recession curve analysis, defines four vulnerability scenarios with an evaluation of the appropriate dimensions of the protection areas, accommodating situations where field-test data are not available. The new approach makes it easier to separate the components of the spring discharge hydrograph. The objective is to achieve simplification, and an effective, more rigorous, procedure in the determination of the parameters used by Mangin’s model—Mangin A (1975) Contribution a l’étude hydrodynamique des aquifères karstiques-Troisieme partie: Constitution et fonctionnement des aquifères karstiques (Contribution to the hydrodynamic study of karst aquifers, part 3: formation and work of karst aquifers). Ann Speleol 30(1):21 124. The original procedure, plus the lack of sufficient data, was open to subjective interpretation. With the aid of modern technology, a very large quantity of data is now available and it is necessary to process it using denoise type computer-based filters before passing to interpretation. Working with discharge data series, a statistical approach is proposed to give an analytical solution for determining the values of fundamental parameters of the recession curve model. The new procedure is defined and compared with the original methodology. The new approach has been tested and applied to a number of karst springs in Italy. A case history for a spring located in the Piedmont region of the Maritime Alps, is presented. The proposed new procedure can be utilised to mark the limits of the protection zones of tapped groundwater supplied for potable use, as required by European and local legislation.

  7. The geomorphological origin of recession curves

    NASA Astrophysics Data System (ADS)

    Biswal, B.; Marani, M.

    2010-12-01

    We identify a previously undetected link between the river network morphology and key recession curves properties through a conceptual-physical model of the drainage process of the riparian unconfined aquifer. We show that the power-law exponent, ? of -dQ/dt vs Q curves is related to the power-law exponent of N(l) vs G(l) curves (which we show to be connected to Hack's law), where l is the downstream distance from the channel heads, N(l) is the number of channel reaches exactly located at a distance l from their channel head, and G(l) is the total length of the network located at a distance greater or equal to l from channel heads. Using Digital Terrain Models and daily discharge observations from 67 US basins we find that geomorphologic ? estimates match well the values obtained from recession curves analyses. Finally, we argue that the link between recession flows and network morphology points to an important role of low-flow discharges in shaping the channel network.

  8. Understanding Subsurface Flow Mechanisms by Studying Recession Flow Curves

    NASA Astrophysics Data System (ADS)

    patnaik, S.; Biswal, B.; D, N.

    2013-12-01

    The recession flows offer valuable information on the subsurface systems of the drainage which cannot be observed due to technological limitations. Many analytical frameworks have been proposed in the past to analyze recession flow curves assess. Among them the most widely used one is Brutsaert-Neiber method of expressing negative time derivative of Q (discharge at the basin outlet at time t), -dQ/dt, as a function of Q itself, which eliminates the need of finding a reference time. Typically, basins across geographical regions display a power law relationship of the type: -dQ/dt = kQ^?. For a particular basin, the exponent ? remains fairly constant recession events while the coefficient k varies greatly from one recession event to another, indicating the dynamic nature -dQ/dt-Q relationship. Recent observations show that subsurface storage in a basin mainly controls the dynamic parameter k. As subsurface water takes long time to fully drain, k of a recession event can also be influenced by the storage that occurred during the past rainfall events. We indirectly analyze the effect of past storage on recession flow by considering past streamflow as a proxy of past storage. A stronger relationship implies that the basin is able to store water for longer duration, and vice versa. In this study, we used streamflow data from 388 USGS basins that are relatively unaffected by human activities to find out the factors that affect the relationship between the power law correlation (R^2_PN) between past discharge and k, where the subscript N is the number of days of past streamflow observations considered for the recession event. For most of the basins R^2_PN decreases with N. We then selected 18 physical and climatological parameters for each study basin and investigated how they influence the value of R^2_PN for each N. We followed multiple linear regression method and found that R^2_PN is strongly influenced by the selected parameters (R^2 = 0.58) for N =30 days. We also employed principal component analysis to identify influence of individual parameters on R^2_PN. Our findings strongly indicate the possibility of understanding subsurface flow mechanism by merely analyzing recession flow curves.

  9. Baseflow Recession Analysis for Comparison of Drainage Basins and Geology

    Microsoft Academic Search

    Walter G. Knisel

    1963-01-01

    By means of baseflow recession analysis a method of comparing drainage basins and geologic formations with the aquifers at, maximum performance has been developed. With the technique it is possible to analyze data for perennial and intermittent streams. A minimum of subjective judgments is involved, so that comparable results can be obtained from inde- lendent investigations. The baseflow recession curve

  10. Recession, S-curves and Digital Equipment Corporation

    E-print Network

    Paris-Sud XI, Université de

    Recession, S-curves and Digital Equipment Corporation David T. Goodwin1 , Roger G. Johnson2 it conformed to this model in the first thirty years but missed out on the disruptive technology of PCs one of the first venture capital companies, led by General Georges Doriot. Olsen created the business

  11. Stream recession curves and storage variability in small watersheds

    NASA Astrophysics Data System (ADS)

    Krakauer, N. Y.; Temimi, M.

    2011-07-01

    The pattern of streamflow recession after rain events offers clues about the relationship between watershed runoff (observable as river discharge) and water storage (not directly observable) and can help in water resource assessment and prediction. However, there have been few systematic assessments of how streamflow recession varies across flow rates and how it relates to independent assessments of terrestrial water storage. We characterized the streamflow recession pattern in 61 relatively undisturbed small watersheds (1-100 km2) across the coterminous United States with multiyear records of hourly streamflow from automated gauges. We used the North American Regional Reanalysis to help identify periods where precipitation, snowmelt, and evaporation were small compared to streamflow. The order of magnitude of the recession timescale increases from 1 day at high flow rates (~1 mm h-1) to 10 days at low flow rates (~0.01 mm h-1), leveling off at low flow rates. There is significant variability in the recession timescale at a given flow rate between basins, which correlates with climate and geomorphic variables such as the ratio of mean streamflow to precipitation and soil water infiltration capacity. Stepwise multiple regression was used to construct a six-variable predictive model that explained some 80 % of the variance in recession timescale at high flow rates and 30-50 % at low flow rates. Seasonal and interannual variability in inferred storage shows similar time evolution to regional-scale water storage variability estimated from GRACE satellite gravity data and from land surface modeling forced by observed meteorology, but is up to a factor of 10 smaller. Study of this discrepancy in the inferred storage amplitude may provide clues to the range of validity of the recession curve approach to relating runoff and storage.

  12. Effects of Antecedent Storage on Inter-Seasonal Recession Curve Variability

    NASA Astrophysics Data System (ADS)

    Bart, R. R.; Hope, A. S.

    2012-12-01

    Understanding the relation between streamflow recession rates and antecedent storage conditions is important for managing riparian ecosystems and forecasting low flows. This understanding is of particular interest in California watersheds where the climate regime is characterized by a large inter-seasonal contrast in precipitation that is out of phase with potential ET, leading to large differences in storage conditions between the beginning and the end of the winter wet season. The objective of this study was to investigate how streamflow recession rates in four watersheds located in the Santa Lucia Mountains of central California vary with antecedent streamflow, which was treated as an indicator of watershed storage conditions. Streamflow recession curves were grouped by antecedent streamflow and compared via examination of their recession slope curve on a log(-dQ/dt)-log(Q) plot. The results indicate that streamflow recession rates decrease with increasing antecedent streamflow. The relation between antecedent streamflow and recession rate follows a negative power law function, with a rapid decrease in recession rate following initial streamflow-producing events. This decrease is likely associated with a shift in the dominant source of recession flows from fast to slow stores as storage levels build up in slow parts of the watershed throughout the wet season. This paper concludes that evaluation of the effect inter-seasonal differences in storage conditions, not just evapotranspiration, is necessary for properly characterizing streamflow recession curves.

  13. Stream recession curves and storage variability in small watersheds

    NASA Astrophysics Data System (ADS)

    Krakauer, N. Y.; Temimi, M.

    2011-02-01

    The pattern of streamflow recession after rain events offers clues about the relationship between watershed runoff (observable as river discharge) and water storage (not directly observable) and can help in water resource assessment and prediction. However, it has not been systematically analyzed across flow rates or related to independent assessments of terrestrial water storage. We characterized the streamflow recession pattern in 61 relatively undisturbed small watersheds (1-100 km2) across the coterminous United States with multiyear records of hourly streamflow from automated gauges. We used the North American Regional Reanalysis (NARR) to help identify periods where precipitation, snowmelt, and evaporation were small compared to streamflow. The order of magnitude of the recession timescale increases from 1 day at high flow rates (~1 mm/h) to 10 days at low flow rates (~0.01 mm/h), leveling off at low flow rates. There is significant variability in the recession timescale at a given flow rate between basins, correlated with climate and geomorphic variables such as the ratio of mean streamflow to precipitation and soil water infiltration capacity. Stepwise multiple regression was used to construct a six-variable predictive model that explained some 80% of the variance in recession timescale at high flow rates and 30-50% at low flow rates. Seasonal and interannual variability in storage shows similar time evolution to but is up to a factor of 10 smaller than regional-scale water storage variability estimated from GRACE satellite gravity data and from land surface modeling forced by observed meteorology. The discrepancy may point to a "disconnection" between the conceptual pool that supplies streamflow during dry periods and other dynamic pools such as soil moisture and deep groundwater.

  14. Fully automated objective-based method for master recession curve separation.

    PubMed

    Posavec, Kristijan; Parlov, Jelena; Naki?, Zoran

    2010-01-01

    The fully automated objective-based method for master recession curve (MRC) separation was developed by using Microsoft Excel spreadsheet and Visual Basic for Applications (VBA) code. The core of the program code is used to construct an MRC by using the adapted matching strip method (Posavec et al. 2006). Criteria for separating the MRC into two or three segments are determined from the flow-duration curve and are represented as the probable range of percent of flow rate duration. Successive separations are performed automatically on two and three MRCs using sets of percent of flow rate duration from selected ranges and an optimal separation model scenario, having the highest average coefficient of determination R(2), is selected as the most appropriate one. The resulting separated master recession curves are presented graphically, whereas the statistics are presented numerically, all in separate sheets. Examples of field data obtained from two springs in Istria, Croatia, are used to illustrate its application. The freely available Excel spreadsheet and VBA program ensures the ease of use and applicability for larger data sets. PMID:20100291

  15. A computer program for predicting recharge with a master recession curve

    USGS Publications Warehouse

    Heppner, Christopher S.; Nimmo, John R.

    2005-01-01

    Water-table fluctuations occur in unconfined aquifers owing to ground-water recharge following precipitation and infiltration, and ground-water discharge to streams between storm events. Ground-water recharge can be estimated from well hydrograph data using the water-table fluctuation (WTF) principle, which states that recharge is equal to the product of the water-table rise and the specific yield of the subsurface porous medium. The water-table rise, however, must be expressed relative to the water level that would have occurred in the absence of recharge. This requires a means for estimating the recession pattern of the water-table at the site. For a given site there is often a characteristic relation between the water-table elevation and the water-table decline rate following a recharge event. A computer program was written which extracts the relation between decline rate and water-table elevation from well hydrograph data and uses it to construct a master recession curve (MRC). The MRC is a characteristic water-table recession hydrograph, representing the average behavior for a declining water-table at that site. The program then calculates recharge using the WTF method by comparing the measured well hydrograph with the hydrograph predicted by the MRC and multiplying the difference at each time step by the specific yield. This approach can be used to estimate recharge in a continuous fashion from long-term well records. Presented here is a description of the code including the WTF theory and instructions for running it to estimate recharge with continuous well hydrograph data.

  16. New baseflow separation and recession analysis approaches for streamflow

    NASA Astrophysics Data System (ADS)

    Stewart, M. K.

    2014-06-01

    Understanding and modelling the relationship between rainfall and runoff has been a driving force in hydrology for many years. Baseflow separation and recession analysis have been two of the main tools for understanding runoff generation in catchments, but there are many different methods for each and no consensus on how best to apply them. A new baseflow separation method is presented, which is justified by being based generally on the more objective tracer separation methods and by being optimised by fitting to the recession hydrograph. Using this baseflow separation method, the thesis is advanced that recession analysis should be applied to the separated components (quickflow and baseflow), because of their very different origins and characteristics, rather than to the streamflow itself because analysing the latter alone gives misleading results. Applying baseflow separation before recession analysis sheds new light on water storage in catchments and may resolve some current problems with recession analysis. It may also have implications for rainfall-runoff modelling. Among other things it shows that both quickflow and baseflow reservoirs have non-linear (quadratic) characteristics in the studied catchment (Glendhu, New Zealand).

  17. Using Hydrograph Recession Analysis for Linking Hydrology to Chemistry: A Flow Regime Approach

    NASA Astrophysics Data System (ADS)

    Doctor, D. H.

    2003-12-01

    Hydrograph recession analysis is of great utility for the interpretation of water quality data, particularly when examining the hydrological processes responsible for runoff generation and impacts of changing land use on water quality. The theoretical basis for hydrograph recession analysis is well known, however the technique has traditionally been under-utilized for studies in which water quality is linked to runoff. Here, a 3-step approach is outlined for such investigations. First, long-term flow recessions are compiled in order to construct a Master Recession Curve (MRC) at a particular point of discharge (e.g., a stream reach, spring, or weir), taking any major seasonal effects into account. Second, the MRC is subsequently divided into flow regimes (from peak flow to baseflow) based upon changes in the recession coefficients that arise from the hydrograph recession analysis. Finally, observed chemical data that fall within the identified flow regimes are statistically described and reduced through principle components analysis (PCA) or other means, allowing for more focused interpretation of water quality variability and prediction according to flow conditions. Characterization of the flow regimes is the crucial link between discharge and water quality for it grants the hydrologist the ability to look for patterns and trends within a reduced set of flow-dependent water quality variables. In conjunction with an end-member mixing model that utilizes solute and isotope tracer data, hydrograph separation and end-member mixing analysis (EMMA) can be performed individually on the identified flow regimes. This approach can provide quantitative information about contributions to discharge derived from chemically distinct water sources in accordance with the flow regimes of the system. Examples from a forested headwater watershed and spring flow from a karst region are presented.

  18. Statistical Decline Curve Analysis

    Microsoft Academic Search

    Robert McNulty; Roy Knapp

    1981-01-01

    The best hyberbolic curve is numerically fit to production decline data from selected oil wells. A non-linear optimization computer program finds the three best values of the general hyperbolic parameters using least squares regression. By using weighted residuals better history matching is obtained than with previous least squares methods. The future rate-time behavior of a well with only a few

  19. Aerodynamic Analysis of Simulated Heat Shield Recession for the Orion Command Module

    NASA Technical Reports Server (NTRS)

    Bibb, Karen L.; Alter, Stephen J.; Mcdaniel, Ryan D.

    2008-01-01

    The aerodynamic effects of the recession of the ablative thermal protection system for the Orion Command Module of the Crew Exploration Vehicle are important for the vehicle guidance. At the present time, the aerodynamic effects of recession being handled within the Orion aerodynamic database indirectly with an additional safety factor placed on the uncertainty bounds. This study is an initial attempt to quantify the effects for a particular set of recessed geometry shapes, in order to provide more rigorous analysis for managing recession effects within the aerodynamic database. The aerodynamic forces and moments for the baseline and recessed geometries were computed at several trajectory points using multiple CFD codes, both viscous and inviscid. The resulting aerodynamics for the baseline and recessed geometries were compared. The forces (lift, drag) show negligible differences between baseline and recessed geometries. Generally, the moments show a difference between baseline and recessed geometries that correlates with the maximum amount of recession of the geometry. The difference between the pitching moments for the baseline and recessed geometries increases as Mach number decreases (and the recession is greater), and reach a value of -0.0026 for the lowest Mach number. The change in trim angle of attack increases from approx. 0.5deg at M = 28.7 to approx. 1.3deg at M = 6, and is consistent with a previous analysis with a lower fidelity engineering tool. This correlation of the present results with the engineering tool results supports the continued use of the engineering tool for future work. The present analysis suggests there does not need to be an uncertainty due to recession in the Orion aerodynamic database for the force quantities. The magnitude of the change in pitching moment due to recession is large enough to warrant inclusion in the aerodynamic database. An increment in the uncertainty for pitching moment could be calculated from these results and included in the development of the aerodynamic database uncertainty for pitching moment.

  20. Estimating parental relationship in linkage analysis of recessive traits

    SciTech Connect

    Merette, C. [Universite Laval Robert-Giffard, Beauport, Quebec (Canada)] [Universite Laval Robert-Giffard, Beauport, Quebec (Canada); Ott, J. [Columbia Univ., New York, NY (United States)] [Columbia Univ., New York, NY (United States)

    1996-05-17

    In linkage analysis of recessive traits, parental relationship is important. For the case that it is unknown, the question is investigated as to whether estimating parental relationship and using the estimated relationship in linkage analysis is beneficial. Results show that estimating parental relationship can reliably be carried out on the basis of 50-100 genetic marker loci (analysis based on theory by Thompson). Misspecification of parental relationship leads to a loss of linkage informativeness, but not to false-positive evidence for linkage. An asymptotic bias in the recombination fraction estimate occurs when parents are unrelated and falsely taken to be related, but no such bias is seen when related parents are taken to be unrelated. Results from this investigation suggest that an estimated parental relationship may be used in linkage analysis as if it were the correct relationship, when evidence for the estimated relationship is supported by a likelihood ratio of at least 10:1 against the parents being unrelated. 9 refs., 2 figs., 5 tabs.

  1. Decline curve analysis using type curves: Case histories

    Microsoft Academic Search

    M. J. Fetkovich; M. D. Bradley; U. G. Kiesow; M. E. Vienot

    1984-01-01

    The purpose of this paper is to present case history studies that demonstrate methods of analyzing rate-time data to predict future production and to determine reservoir variables. Constant wellbore pressure analysis techniques are demonstrated, using existing q \\/SUB Dd\\/ - t \\/SUB Dd\\/ type curves along with developing new q \\/SUB Dd\\/ - t \\/SUB Dd\\/ type curves from actual

  2. Hydromorphologic Recession Analysis: Accounting for Human Influences in Watershed Behaviors

    NASA Astrophysics Data System (ADS)

    Thomas, B. F.; Famiglietti, J. S.

    2013-12-01

    Integrated management of ground and surface waters has generally relied on baseflow characterization to understand the temporal variability in the contribution of watershed storage to streamflow. Recent research, however, indicates that small disturbances attributed to humans can impact our ability to characterize baseflow behaviors. In this study, we present an approach to account for human impacts on the estimation of baseflow recession parameters in California's Central Valley. The framework assesses how baseflow characterization is impacted by the combination of groundwater abstractions and surface water management strategies used to meet both residential and agricultural water demands. The results highlight the importance of accounting for human influences to characterize watershed properties by evaluating traditional (i.e. natural) and human-corrected recession parameters. Such results can influence studies ranging from water resources management to stream restoration projects that rely on accurate accounting of baseflow, especially during low flows.

  3. Comparative analysis between analytical approximations and numerical solutions describing recession flow in unconfined hillslope aquifers

    Microsoft Academic Search

    David Rocha; Jan Feyen; Alain Dassargues

    2007-01-01

    Recession flow of aquifers from a hillslope can be described by the non-linear Boussinesq equation. Under strong assumptions\\u000a and for specific conceptual formulations, different authors derived analytical approximations or linearized versions to this\\u000a partial differential equation. A comparative analysis between some analytical approximations of the Boussinesq equation and\\u000a the numerical solution of the recession flow of an unconfined homogeneous aquifer

  4. Analysis of Curve Reconstruction by Meshless Parameterization

    E-print Network

    Floater, Michael S.

    Analysis of Curve Reconstruction by Meshless Parameterization Michael S. Floater Abstract: This paper proposes and analyzes a method called meshless parameterization for reconstructing curves from they are visited by c. We propose here a new method of curve reconstruction, called meshless parameteri- zation

  5. Technical Note: A measure of watershed nonlinearity II: re-introducing an IFP inverse fractional power transform for streamflow recession analysis

    NASA Astrophysics Data System (ADS)

    Ding, J. Y.

    2013-12-01

    This note illustrates, in the context of Brutsaert-Nieber (1977) model: -dQ/dt = aQb, the utility of a newly rediscovered inverse fractional power (IFP) transform of the flow rates. This method of streamflow recession analysis dates back a half-century. The IFP transform ?b on an operand Q is defined as ?b Q = 1/Qb-1. Brutsaert-Nieber model by IFP transform thus becomes: ?bQ(t) = ?bQ(0) + (b-1) at, if b ≠ 1. The IFP transformed recession curve appears as a straight line on a semi-IFP plot. The method has both the advantage of being independent of the size of computational time step, and the disadvantage of being depending on the parameter b value. This is used to calibrate the Brutsaert-Nieber recession flow model in which b is a slope (or shape) parameter, and a is an intercept (or a scale parameter). It is applied to four observed events on the Spoon River in Illinois (4237 km2). The results show that the IFP transform method gives a narrower range of parameter b values than the regression method in a recession plot. Theoretically, an IFP transformed recession curve for large watersheds falls between those performed by the reciprocal of the cubic root (RoCR) transform and the reciprocal of the square root (RoSR) one. In general, the forgotten IFP transform method merits a fresh look, especially for hillslopes and zero-order catchments, the building blocks of a watershed system. In particular, because of its origin in hillslope hydrology, the 1-parameter RoSR transform need be falsified or verified for application to headwater catchments.

  6. OIL PRODUCTION FORECASTING BY DECLINE CURVE ANALYSIS

    Microsoft Academic Search

    Robert Mannon

    1965-01-01

    The subject of analyzing oil-well production-decline curves is examined in detail. The problem is approached from the standpoints of raw data validity, techniques of data handling, modes of graphic representation, and final interpretation procedures. Forms of analysis based on mathematical treatments, factors of analogy and experience, and predicted reservoir behavior efforts are discussed. It is evident that all of the

  7. Numerical Analysis of Galactic Rotation Curves

    E-print Network

    Scelza, G

    2015-01-01

    In this paper we present the discussion on the salient points of the computational analysis that are at the basis of the paper \\emph{Rotation Curves of Galaxies by Fourth Order Gravity} \\citep{StSc}. In fact in this paper any galactic component (bulge, disk and Dark matter component) required an onerous numerical computation since the Gauss theorem is not applicable in the Fourth Order Gravity. The computational and data analysis have been made with the software Mathematica$^\\circledR$.

  8. What Is a Recessive Allele?

    ERIC Educational Resources Information Center

    American Biology Teacher, 1991

    1991-01-01

    Presents four misconceptions students have concerning the concepts of recessive and dominant alleles. Discusses the spectrum of dominant-recessive relationships, different levels of analysis between phenotype and genotype, possible causes of dominance, and an example involving wrinkled peas. (MDH)

  9. Complex Fluid Analysis with the Advanced Distillation Curve Approach

    E-print Network

    Complex Fluid Analysis with the Advanced Distillation Curve Approach Thomas J. Bruno, Lisa S. Ott for measuring distillation curves reveals the physicochemical properties of complex fluids such as fuels distillation curves of complex fluids. The distillation curve provides the only practical avenue to assess

  10. Similarity Analysis between near surface soil moisture and streamflow during recession events in an alpine catchment

    NASA Astrophysics Data System (ADS)

    Mutzner, Raphael; Weijs, Steven V.; Rinaldo, Andrea; Parlange, Marc B.

    2013-04-01

    Spatial and temporal variability of near surface soil moisture is important for understanding streamflow generation in high altitude mountain catchments since antecedent soil moisture plays an important role in the timing of runoff. For relatively small to medium sized catchments, the spatial variability of near surface soil moisture is hard to capture with remote sensing techniques and distributed point measurements are needed. Linking local measurements of soil moisture with integrating catchment scale streamflow measurements remains a great challenge in hydrological modeling. Since 2008, an alpine watershed of 20.4 km2 has been intensively monitored in the Swiss Alps, with a deployment of a network of wireless meteorological stations, measuring soil moisture along with other meteorological forcings. The discharge is monitored at three different sites. We present some preliminary results from a statistical analysis linking the spatial variation of the soil moisture, measured at 20 and 40 cm, with the variation of the streamflow in the particular case of recession events. A classic parameterization of recession events relating the variation of the discharge dQ-dt to the discharge Q by |dQ-dt|? Q? is used and transposed to soil moisture data. The parameterized soil moisture variation is then partitioned into runoff and evapotranspiration leading to better knowledge of local processes at the hillslope scale.

  11. Rapid multipoint linkage analysis of recessive traits in nuclear families, including homozygosity mapping

    SciTech Connect

    Kruglyak, L.; Daly, M.J. [Whitehead Institute for Biomedical Research, Cambridge, MA (United States); Lander, E.S. [Whitehead Institute for Biomedical Research, Cambridge, MA (United States)]|[Massachusetts Institute of Technology, Cambridge, MA (United States)

    1995-02-01

    Homozygosity mapping is a powerful strategy for mapping rare recessive traits in children of consanguineous marriages. Practical applications of this strategy are currently limited by the inability of conventional linkage analysis software to compute, in reasonable time, multipoint LOD scores for pedigrees with inbreeding loops. We have developed a new algorithm for rapid multipoint likelihood calculations in small pedigrees, including those with inbreeding loops. The running time of the algorithm grows, at most, linearly with the number of loci considered simultaneously. The running time is not sensitive to the presence of inbreeding loops, missing genotype information, and highly polymorphic loci. We have incorporated this algorithm into a software package, MAPMAKER/HOMOZ, that allows very rapid multipoint mapping of disease genes in nuclear families, including homozygosity mapping. Multipoint analysis with dozens of markers can be carried out in minutes on a personal workstation. 23 refs., 4 figs., 1 tab.

  12. Statistical Analysis of Single-Molecule AFM Force Spectroscopy Curves

    E-print Network

    Schmidler, Scott

    Statistical Analysis of Single-Molecule AFM Force Spectroscopy Curves Alexei Valiaev1,2 , Stefan-extension curves obtained from single-molecule force spectroscopy (SMFS) measurements. We apply this methodology: Statistical Analysis of AFM Curves Keywords: atomic force microscopy, freely-jointed chain, worm-like chain

  13. Autosomal recessive

    MedlinePLUS

    ... and the other gene comes from the father. Recessive inheritance means both genes in a pair must be abnormal to cause ... born to parents who carry the same autosomal recessive change ... abnormal gene from both parents and developing the disease. You ...

  14. Analysis of Data When the Response is a Curve

    Microsoft Academic Search

    Alonzo Church

    1966-01-01

    A method is presented for reducing a curvilinear response to a set of numbers which describe the curve. An analysis of such numbers including reconstruction of the curves is presented. A numerical example is used to illustrate the entire procedure.

  15. Estimating basin-wide hydraulic parameters of a semi-arid mountainous watershed by recession-flow analysis

    Microsoft Academic Search

    Guillermo F. Mendoza; Tammo S. Steenhuis; M. Todd Walter; J.-Yves Parlange

    2003-01-01

    Insufficient sub-surface hydraulic data from watersheds often hinders design of water resources structures. This is particularly true in developing countries and in watersheds with low population densities because well-drilling to obtain the hydraulic data is expensive. The objective of this study was to evaluate the applicability of ‘Brutsaert’ recession flow analysis to steeper and more arid watersheds than those that

  16. Selecting Elliptic Curves for Cryptography: An Efficiency and Security Analysis

    E-print Network

    Selecting Elliptic Curves for Cryptography: An Efficiency and Security Analysis Joppe W. Bos, Craig related to both efficiency and security since the initial standardiza- tion of elliptic curve cryptography curves for cryptography and analyze our selection from a performance and security perspective

  17. The Informative Analysis of Individual Trend Curves

    ERIC Educational Resources Information Center

    McDonald, Roderick P.

    2004-01-01

    Additive and non-additive models for an individual trend curve are examined, and five methods for fitting these to a set of individuals are described. It is suggested that classical fitting methods are more informative than latent curve methods, and commonly preferable. A limited study of the effect of time-structure is reported, and results on…

  18. Phenomenological analysis of the clotting curve

    Microsoft Academic Search

    Raimondo De Cristofaro; Enrico Di Cera

    1991-01-01

    A model-independent (phenomenological) characterization of the clotting curve is proposed. Three parameters are used to encapsulate the main features of the increase in absorbance observed at 350 nm due to the reaction of thrombin with fibrinogen that leads to clot formation: (1) the maximum increase in absorbance per unit time, ?Am, at the inflection point of the clotting curve; (2)

  19. Mutation analysis of 272 Spanish families affected by autosomal recessive retinitis pigmentosa using a genotyping microarray

    PubMed Central

    Ávila-Fernández, Almudena; Cantalapiedra, Diego; Aller, Elena; Vallespín, Elena; Aguirre-Lambán, Jana; Blanco-Kelly, Fiona; Corton, M.; Riveiro-Álvarez, Rosa; Allikmets, Rando; Trujillo-Tiebas, María José; Millán, José M.; Cremers, Frans P.M.

    2010-01-01

    Purpose Retinitis pigmentosa (RP) is a genetically heterogeneous disorder characterized by progressive loss of vision. The aim of this study was to identify the causative mutations in 272 Spanish families using a genotyping microarray. Methods 272 unrelated Spanish families, 107 with autosomal recessive RP (arRP) and 165 with sporadic RP (sRP), were studied using the APEX genotyping microarray. The families were also classified by clinical criteria: 86 juveniles and 186 typical RP families. Haplotype and sequence analysis were performed to identify the second mutated allele. Results At least one-gene variant was found in 14% and 16% of the juvenile and typical RP groups respectively. Further study identified four new mutations, providing both causative changes in 11% of the families. Retinol Dehydrogenase 12 (RDH12) was the most frequently mutated gene in the juvenile RP group, and Usher Syndrome 2A (USH2A) and Ceramide Kinase-Like (CERKL) were the most frequently mutated genes in the typical RP group. The only variant found in CERKL was p.Arg257Stop, the most frequent mutation. Conclusions The genotyping microarray combined with segregation and sequence analysis allowed us to identify the causative mutations in 11% of the families. Due to the low number of characterized families, this approach should be used in tandem with other techniques. PMID:21151602

  20. Stochastic Analysis of Wind Turbine Power Curves Edgar Anahua

    E-print Network

    Peinke, Joachim

    of the wind turbine to its desired power production; and ii) the stochastic force (noise), whichStochastic Analysis of Wind Turbine Power Curves Edgar Anahua Oldenburg 2007 Zur Homepage der Dissertation #12;#12;Stochastic Analysis of Wind Turbine Power Curves Edgar Anahua Von der Fakult¨at f

  1. Statistical Analysis of Single-Molecule AFM Force Spectroscopy Curves

    E-print Network

    Schmidler, Scott

    Statistical Analysis of Single-Molecule AFM Force Spectroscopy Curves Alexei Valiaev1 , Stefan from single-molecule force spectroscopy (SMFS) measurements. We apply this methodology to force. Running title: Statistical Analysis of AFM Curves Keywords: atomic force microscopy, freely-jointed chain

  2. Whole Exome Analysis Identifies Frequent CNGA1 Mutations in Japanese Population with Autosomal Recessive Retinitis Pigmentosa

    PubMed Central

    Katagiri, Satoshi; Akahori, Masakazu; Sergeev, Yuri; Yoshitake, Kazutoshi; Ikeo, Kazuho; Furuno, Masaaki; Hayashi, Takaaki; Kondo, Mineo; Ueno, Shinji; Tsunoda, Kazushige; Shinoda, Kei; Kuniyoshi, Kazuki; Tsurusaki, Yohinori; Matsumoto, Naomichi; Tsuneoka, Hiroshi; Iwata, Takeshi

    2014-01-01

    Objective The purpose of this study was to investigate frequent disease-causing gene mutations in autosomal recessive retinitis pigmentosa (arRP) in the Japanese population. Methods In total, 99 Japanese patients with non-syndromic and unrelated arRP or sporadic RP (spRP) were recruited in this study and ophthalmic examinations were conducted for the diagnosis of RP. Among these patients, whole exome sequencing analysis of 30 RP patients and direct sequencing screening of all CNGA1 exons of the other 69 RP patients were performed. Results Whole exome sequencing of 30 arRP/spRP patients identified disease-causing gene mutations of CNGA1 (four patients), EYS (three patients) and SAG (one patient) in eight patients and potential disease-causing gene variants of USH2A (two patients), EYS (one patient), TULP1 (one patient) and C2orf71 (one patient) in five patients. Screening of an additional 69 arRP/spRP patients for the CNGA1 gene mutation revealed one patient with a homozygous mutation. Conclusions This is the first identification of CNGA1 mutations in arRP Japanese patients. The frequency of CNGA1 gene mutation was 5.1% (5/99 patients). CNGA1 mutations are one of the most frequent arRP-causing mutations in Japanese patients. PMID:25268133

  3. Genetic analysis of loci that contribute to recessive polycystic kidney disease in the mouse

    SciTech Connect

    Beier, D.R.; Dushkin, H.; Tobin, D. [Harvard Medical School, Boston, MA (United States)] [and others

    1994-09-01

    Identification of genes that play a role in the development of autosomal recessive polycystic kidney disease (ARPKD) is a key to the better understanding of this disorder. We have discovered a new mutation in the mouse we call juvenile cystic kidney (jck) which predisposes to the development of ARPKD and is not allelic with any previously described mutations. In an effort to map and positionally clone the jck gene, an intraspecific intercross between B6/DBA jck/+F1 mice was established and over 100 affected progeny were identified. Genotype analysis using microsatellite markers was employed and the jck mutation has been mapped to a 1 cM interval on mouse chromosome 11. Positional cloning of this mutant locus by employing a YAC contig is in progress. Narrowing the region of interest has been facilitated by the utilization of SSCP analysis to develop informative markers from YAC sequence. In addition, it was noted that severity of disease in the intercross progeny (as measured by the degree of kidney enlargement) was more variable than that observed in the parental B6 strain. This suggested that a modifier locus introduced form the DBA background affects the expression of the jck phenotype. We have determined that two additional regions - one from DBA on distal chromosome 10 and a second from B6 on chromosome 1 - are strongly associated with inheritance of a more severe polycystic kidney disease phenotype. The finding of a highly significant association of a B6-related locus with kidney enlargement was completely unexpected, since the PKD phenotype in the original B6 background is not severe. This finding is unambiguous, with a maximal quantitative trait locus (QTL) analysis LOD score of 15 for association with disease severity. We propose that it is the inheritance of both a homozygous B6 locus on chromosome 1 and a DBA gene that results in the severe phenotype, presumably as a consequence of an interaction between their protein products.

  4. Linkage and sequence analysis indicate that CCBE1 is mutated in recessively inherited generalised lymphatic dysplasia.

    PubMed

    Connell, Fiona; Kalidas, Kamini; Ostergaard, Pia; Brice, Glen; Homfray, Tessa; Roberts, Lesley; Bunyan, David J; Mitton, Sally; Mansour, Sahar; Mortimer, Peter; Jeffery, Steve

    2010-02-01

    Generalised lymphatic dysplasia (GLD) is characterised by extensive peripheral lymphoedema with visceral involvement. In some cases, it presents in utero with hydrops fetalis. Autosomal dominant and recessive inheritance has been reported. A large, non-consanguineous family with three affected siblings with generalised lymphatic dysplasia is presented. One child died aged 5 months, one spontaneously miscarried at 17 weeks gestation, and the third has survived with extensive lymphoedema. All three presented with hydrops fetalis. There are seven other siblings who are clinically unaffected. Linkage analysis produced two loci on chromosome 18, covering 22 Mb and containing 150 genes, one of which is CCBE1. A homozygous cysteine to serine change in CCBE1 has been identified in the proband, in a residue that is conserved across species. High density SNP analysis revealed homozygosity (a region of 900 kb) around the locus for CCBE1 in all three affected cases. This indicates a likely ancestral mutation that is common to both parents; an example of a homozygous mutation representing Identity by Descent (IBD) in this pedigree. Recent studies in zebrafish have shown this gene to be required for lymphangiogenesis and venous sprouting and are therefore supportive of our findings. In view of the conserved nature of the cysteine, the nature of the amino acid change, the occurrence of a homozygous region around the locus, the segregation within the family, and the evidence from zebrafish, we propose that this mutation is causative for the generalised lymphatic dysplasia in this family, and may be of relevance in cases of non-immune hydrops fetalis. PMID:19911200

  5. Tearing instability analysis handbook. Formulas and curves

    SciTech Connect

    Tada, H,; Paris, P.C.

    1980-01-01

    Handbook style information is presented for tearing instability formulas on typical test configuration. It is the J-integral resistance (J-R) curve that forms the basis of the tearing stability concept. Stability of crack growth is judged by the tearing modulus criterion.

  6. Decline curve analysis for horizontal wells

    E-print Network

    Shih, Min-Yu

    1994-01-01

    DW XeD 10 XeD 20 fDA pwD pwD this study ref. 6 pw pwD this study ref. a pwD this study pwD ref. 6 pwD pwD this study ref. 6 t. SE~ 2. 0 E~ 3. 0 E-02 4. 0 E-02 S. OE~ 6. 0 E~ S. OE-02 1. 0 E-01 1. 5E-01 2. 0 E-01 3. 0 E-01 4. 0 E-01 S. OE... Example (Well S-48) Using Horizontal Well Type Curve 87 LIST OF FIGURES FIGURE 1. 1 1. 2 2. 1 2. 2 2. 3. a 2. 3. b 2. 3. c 2. 4 2. 5 2. 6 2. 7 2. 8 2. 9 2. 10 2. 11 2. 12 2. 13 3. 1 3. 2 Fetkovich Type Curve for Radial Flow, Circular...

  7. Delamination Analysis Of Composite Curved Bars

    NASA Technical Reports Server (NTRS)

    Ko, William L.; Jackson, Raymond H.

    1990-01-01

    Classical anisotropic elasticity theory used to construct "multilayer" composite semicircular curved bar subjected to end forces and end moments. Radial location and intensity of open-mode delamination stress calculated and compared with results obtained from anisotropic continuum theory and from finite element method. Multilayer theory gave more accurate predictions of location and intensity of open-mode delamination stress. Currently being applied to predict open-mode delamination stress concentrations in horse-shoe-shaped composite test coupons.

  8. Analysis of exponential decay curves of mixtures

    E-print Network

    McGaughey, Robert Lee

    1967-01-01

    INTRODUCTION The object of this research was to determine the efficiency and accuracy of a method of analyzing exponential decay curves of radio- active mixtures by applying linear programming solutions to Prony's method. This research is an extension of a... programs were written to utilize the RAND X028 SIMPLEX subroutine and the CEIR LP/90 system in solving the problem. CHAPTER I I LINEAR PROGRAMMING The general linear programming problem is to minimize some linear objective function, subject to a set...

  9. Mutation analysis of 272 Spanish families affected by autosomal recessive retinitis pigmentosa using a genotyping microarray

    Microsoft Academic Search

    A. Avila-Fernandez; D. Cantalapiedra; E. Aller; E. Vallespin; J. Aguirre-Lamban; F. Blanco-Kelly; M. Corton; R. Riveiro-Alvarez; R. Allikmets; M. J. Trujillo-Tiebas; J. M. Millan; F. P. M. Cremers; C. Ayuso

    2010-01-01

    PURPOSE: Retinitis pigmentosa (RP) is a genetically heterogeneous disorder characterized by progressive loss of vision. The aim of this study was to identify the causative mutations in 272 Spanish families using a genotyping microarray. METHODS: 272 unrelated Spanish families, 107 with autosomal recessive RP (arRP) and 165 with sporadic RP (sRP), were studied using the APEX genotyping microarray. The families

  10. Recession Rebound

    ERIC Educational Resources Information Center

    Weinstein, Margery

    2011-01-01

    A return to normal after a crisis is a good thing. Who doesn't want back what once seemed lost? The problem is it usually isn't a simple task figuring out how to patch together a scaled-back training program. When the recession hit in fall 2008, trainers were asked to scale down programming and make do with fewer resources. With a recovery in full…

  11. Genetic analysis of autosomal recessive osteopetrosis in Chuvashiya: the unique splice site mutation in TCIRG1 gene spread by the founder effect

    PubMed Central

    Bliznetz, Elena A; Tverskaya, Svetlana M; Zinchenko, Rena A; Abrukova, Anna V; Savaskina, Ekaterina N; Nikulin, Maxim V; Kirillov, Alexander G; Ginter, Evgeny K; Polyakov, Alexander V

    2009-01-01

    The rare malignant disorder autosomal recessive osteopetrosis (OPTB) is one of the most prevalent autosomal recessive diseases in the Chuvash Republic of Russia. The purpose of this study was to determine the underlying molecular cause of osteopetrosis in Chuvashiya and to reveal the factors causing the unusual high frequency of the disease in this region. Having assumed a founder effect, we performed linkage disequilibrium (LD) mapping of the OPTB locus at the TCIRG1 region and found a unique splice site mutation c.807+5G>A in all Chuvashian OPTB patients studied. We then analyzed the mutational change in mRNA and detected an intron insertion within the mutant transcript, resulting in a frameshift and premature stop-codon formation (p.Leu271AspfsX231). A decreased expression of the mutant transcript was also detected, which may have been the result of nonsense-mediated decay. Real-time qPCR and MLPA® melting curve analysis-based systems were designed and used for c.807+5G>A mutation screening. In addition to analyzing the gene frequency in Chuvashiya, we also estimated three other populations in the Volga-Ural region (Mari, Udmurt and Bashkir). We found a 1.68% prevalence in Chuvashiya (calculated disease frequency, 1/3500 newborns) and a 0.84% in the Mari population (1/14?000 newborns). The haplotype analysis revealed that all OPTB cases in Chuvashians and Marians originated from a single mutational event and the age of the mutation in Chuvashians was estimated to be approximately 890 years. PMID:19172990

  12. Evaluation of root coverage with and without connective tissue graft for the treatment of single maxillary gingival recession using an image analysis system: a randomized controlled clinical trial.

    PubMed

    Lops, Diego; Gobbato, Luca; Nart, Jose; Guazzo, Riccardo; Ho, Daniel K; Bressan, Eriberto

    2015-01-01

    The aim of this prospective randomized clinical study was to evaluate, by means of an image analysis system, the efficacy of two different surgical procedures for the treatment of Miller Class I and II maxillary gingival recession. Patients treated for maxillary gingival recession were recruited and randomly divided into two groups: patients who received a coronally advanced flap with connective tissue graft (CAF + CTG) or CAF alone. Outcome parameters included complete root coverage, recession reduction, and keratinized tissue amount. Twenty-five patients completed the 12-month follow-up period. Patients in the CAF + CTG group showed a better primary outcome- gingival recession at 12 months-than CAF patients (P = .0001). Gingival recession at 12 months had a median of 0.5 (interquartile range [IQR] 0.5 to 0.6) in the CAF + CTG group and a median of 1.0 (IQR 0.9 to 1.1) in the CAF group. CAF + CTG and CAF groups had similar complete root coverage at 6 and 12 months. Recession and keratinized tissue width significantly decreased over time (P < .0001), with no effect of treatment or of treatment over time. Buccal probing depth had similar values over time (P = .28) and in the two groups (P = .52). Buccal clinical attachment level had similar values in the two groups (P = .87); moreover, mesial and distal clinical attachment levels did not show any variation over time (P = .88 and P = .68, respectively). By means of a computerized image analysis system better outcomes in terms of recession reduction after 12 months of follow-up were measured for maxillary gingival recessions treated with CAF and CTG. Adjunctive application of a CTG under a CAF increased the probability of achieving complete root coverage in maxillary Miller Class I and II defects (61.5% versus 83.3%; P = .38). Both treatments were equally effective in providing a consistent reduction of the baseline recession. PMID:25738345

  13. Theoretical foundations for environmental Kuznets curve analysis

    NASA Astrophysics Data System (ADS)

    Lantz, Van

    This thesis provides a dynamic theory for analyzing the paths of aggregate output and pollution in a country over time. An infinite horizon, competitive growth-pollution model is explored in order to determine the role that economic scale, production techniques, and pollution regulations play in explaining the inverted U-shaped relationship between output and some forms of pollution (otherwise known as the Environmental Kuznets Curve, or EKC). Results indicate that the output-pollution relationship may follow a strictly increasing, strictly decreasing (but bounded), inverted U-shaped, or some combination of curves. While the 'scale' effect may cause output and pollution to exhibit a monotonic relationship, 'technique' and 'regulation' effects may ultimately cause a de-linking of these two variables. Pollution-minimizing energy regulation policies are also investigated within this framework. It is found that the EKC may be 'flattened' or even eliminated moving from a poorly-regulated economy to one that minimizes pollution. The model is calibrated to the US economy for output (gross national product, GNP) and two pollutants (sulfur dioxide, SO2, and carbon dioxide, CO2) over the period 1900 to 1990. Results indicate that the model replicates the observations quite well. The predominance of 'scale' effects cause aggregate SO2 and CO2 levels to increase with GNP in the early stages of development. Then, in the case of SO 2, 'technique' and 'regulation' effects may be the cause of falling SO2 levels with continued economic growth (establishing the EKC). CO2 continues to monotonically increase as output levels increase over time. The positive relationship may be due to the lack of regulations on this pollutant. If stricter regulation policies were instituted in the two case studies, an improved allocation of resources may result. While GNP may be 2.596 to 20% lower than what has been realized in the US economy (depending on the pollution variable analyzed), individual welfare may increase from lower pollution levels.

  14. Gastrocnemius recession.

    PubMed

    Anderson, John G; Bohay, Donald R; Eller, Erik B; Witt, Bryan L

    2014-12-01

    The Grand Rapids Arch Collapse classifications create a novel system for categorizing and correlating numerous common foot and ankle conditions related to a falling arch. The algorithm for treating these conditions is exceptionally replicable and has excellent outcomes. Gastrocnemius equinus diagnosis plays a crucial role in the pathology of arch collapse. A contracture of the gastrocnemius muscle is increasingly recognized as the cause of several foot and ankle conditions. The authors have expanded their indications for gastrocnemius recession to include arch pain without radiographic abnormality, calcaneus apophysitis, plantar fasciitis/fibromas, Achilles tendonosis, early-onset diabetic Charcot arthropathy, and neuropathic forefoot ulcers. PMID:25456721

  15. Time delay analysis in high speed gate-recessed E-mode InAlN HEMTs

    NASA Astrophysics Data System (ADS)

    Sensale-Rodriguez, Berardi; Guo, Jia; Wang, Ronghua; Verma, Jai; Li, Guowang; Fang, Tian; Beam, Edward; Ketterson, Andrew; Schuette, Michael; Saunier, Paul; Gao, Xiang; Guo, Shiping; Snider, Gregory; Fay, Patrick; Jena, Debdeep; Xing, Huili Grace

    2013-02-01

    Delay analysis providing an alternative physical explanation on carrier transport, which may be more applicable to high electron mobility transistor (HEMT) channels with moderate carrier mobilities, has been applied to enhancement-mode (E-mode) and depletion-mode (D-mode) InAlN/AlN/GaN HEMTs with comparable fT at room and cryogenic temperatures. It was found that the speed of the E-mode HEMTs with 33-nm long T-gate is dominated by parasitic delays, >40% of the total delay; channel mobility might have degraded due to gate recess.

  16. Protections against Differential Analysis for Elliptic Curve Cryptography

    Microsoft Academic Search

    Marc Joye; Christophe Tymen

    2001-01-01

    We propose several new methods to protect the scalar multi- plication on an elliptic curve against Dieren tial Analysis. The basic idea consists in transforming the curve through various random morphisms to provide a non-deterministic execution of the algorithm. The solutions we suggest complement and improve the state-of-the-art, but also provide a practical toolbox of ecien t countermeasures. These should

  17. Analysis of radiation embrittlement reference toughness curves. Final report

    Microsoft Academic Search

    W. L. Server; R. A. Wullaert; G. R. Odette; W. Oldfield

    1981-01-01

    Three major tasks were performed: (1) statistial analysis and development of reference fracture toughness curves, (2) evaluation of fracture toughness data from surveillance (small) specimens, and (3) radiation damage analysis and modeling. Results from the first task provided techniques for statistical experimental design of radiation embrittlement programs and proper collection and qualification of experimental mechanical property data. The main accomplishment

  18. Incorporating Experience Curves in Appliance Standards Analysis

    Microsoft Academic Search

    Karina Garbesi; Peter Chan; Jeffery Greenblatt; Colleen Kantner; Alex Lekov; Stephen Meyers; Gregory Rosenquist; Robert Van Buskirk; Hung-Chia Yang; Louis-Benoit Desroches

    2011-01-01

    The technical analyses in support of U.S. energy conservation standards for residential appliances and commercial equipment have typically assumed that manufacturing costs and retail prices remain constant during the projected 30-year analysis period. There is, however, considerable evidence that this assumption does not reflect real market prices. Costs and prices generally fall in relation to cumulative production, a phenomenon known

  19. The great recession of 2007 and California nurses: a descriptive analysis.

    PubMed

    Tellez, Michelle Sardenberg-Hersh; Neronde, Pamela; Wong, Sherly

    2013-05-01

    This study investigates the effect of the Recession of 2007 on nurses' wages, demographics, human capital, and work environment characteristics using data from the California Board of Registered Nursing Surveys of 2006, 2008 and 2010. Findings suggest that the labor force is maximized, with nurses working as much as they can on their primary nursing positions (51 weeks a year). As the economy recovers, the nurse shortage will resurge. Intense focus in three policy areas is recommended: education, faculty training, and recruitment and retention of African Americans, Hispanics, and older nurses. PMID:24036699

  20. Band analysis by spectral curve fitting

    NASA Technical Reports Server (NTRS)

    Lin, C. L.; Shaw, J. H.; Calvert, J. G.

    1980-01-01

    A method of estimating the values of the parameters in the models describing the positions, widths, and intensities of the lines in rotation-vibration bands of gases, without the need for line by line analysis, is described. To illustrate the technique, portions of the 1-0 bands of HCl and CO have been analyzed. The values of up to 27 parameters, their standard deviations, and the correlations between the parameters required to describe the spectra have been obtained.

  1. An analysis of trends in baseflow recession and low-flows in rain-dominated coastal streams of the pacific coast

    NASA Astrophysics Data System (ADS)

    Sawaske, Spencer R.; Freyberg, David L.

    2014-11-01

    The work presented here centers on the identification and calculation of indices representative of annual low-flow conditions and baseflow recession form, and the evaluation of trends in these indices with time for rain-dominated streams of the Pacific coastal mountain ranges. Two different baseflow recession analysis techniques are employed, which when combined are capable of modeling the varied dry-season flow conditions that exist over the broad range of catchments included in the study area. Results indicate that over the past 40-80 years widespread trends of increasing rates of baseflow recession and decreasing annual low-flow conditions exist throughout the region. Of streamgages analyzed, 44% were identified as having a statistically significant trend in either low-flow conditions or recession form with time. While spring flow conditions show little change over the study period, trends of decreasing late-summer flow conditions and increasing rates of recession are particularly common. Northern California and Oregon are especially impacted locations, with upwards of 60% of study gages exhibiting decreasing trends in late summer flow conditions. Detailed conceptual explanations for the connections between trends in recession form and indices of low-flow are also presented.

  2. Baseflow recession analysis in the inland Pacific Northwest of the United States

    NASA Astrophysics Data System (ADS)

    Sánchez-Murillo, R.; Brooks, E. S.; Elliot, W. J.; Gazel, E.; Boll, J.

    2015-03-01

    The storage-discharge relationships of 26 watersheds in the inland Pacific Northwest of the United States were analyzed. Four fitting methods were used to obtain the baseflow coefficients: lower envelope, organic correlation, and ordinary and inverse least squares. Several climatic and terrain attributes were evaluated as predictors of baseflow coefficients. Watersheds dominated by basalt and flatter landscapes exhibited the smallest recession time scales ( K) (12.5-20.0 days). Greater K values (33.3-66.7 days) were obtained over catchments dominated by metamorphic and sedimentary rocks. Mean basin slope and the aridity index were found to be the best estimators of baseflow coefficients. Baseflow in flat basalt landscapes, located in dry warm climates, decrease rapidly during summer months and are most sensitive to future droughts and warming climates. Groundwater systems feeding streams during the driest months can drop to less than 1 mm of effective storage in these sensitive systems. In contrast, the minimum annual storage in mountainous systems can have greater than 10 mm effective storage. By understanding the main factors controlling baseflow recession characteristics, environmental agencies could prioritize efforts in areas where future droughts and land use changes may affect ecological assemblages and socio-economic activities.

  3. Analysis of subthreshold conduction in short-channel recessed source/drain UTB SOI MOSFETs

    NASA Astrophysics Data System (ADS)

    Svili?i?, B.; Jovanovi?, V.; Suligoj, T.

    2010-05-01

    The subthreshold conduction regime in short-channel recessed source/drain (ReS/D) ultra-thin body (UTB) silicon-on-insulator (SOI) MOSFETs is studied. A physics-based model for the subthreshold slope of ReS/D UTB SOI MOSFETs is developed, based on an analytical solution of 2-D Poisson's equation for the front-gate and back-gate potential distributions. In order to verify the accuracy of the model, the calculated subthreshold slope values are compared with the results obtained by Medici 2-D numerical device simulator over a wide range of different device structures, and very good agreement is obtained down to channel lengths of sub-30 nm. The model is given in explicit form without any fitting parameters and requires no iterative calculation, thus making it ideally suitable for fast prediction and evaluation of device design criteria for optimal scaling of the ReS/D UTB SOI MOSFETs.

  4. Useful Concepts for Decline Curve Forecasting, Reserve Estimation, and Analysis

    Microsoft Academic Search

    M. J. Fetkovich; E. J. Fetkovich; M. D. Fetkovich

    1996-01-01

    Decline-curve analysis, based on the Arps equations, has always been considered to be purely empirical with no basis on physical laws governing the flow of oil and gas through the formation. The purpose of this paper is to give engineers responsible for making forecasts and determining reserves for numerous operated or nonoperated wells some guidelines and fundamental concepts to allow

  5. A non-iterative method of decline curve analysis

    Microsoft Academic Search

    Hamid Hosseinzade Khanamiri

    2010-01-01

    Decline curve analysis is one of the reserve estimation methods. It is widely used by companies and engineers. The oldest and most popular method is Arp's empirical equation. There is no theoretical basis for Arp's equations. Exponential equation almost always underestimates the flow rate and cumulative production and on the other hand harmonic decline overestimates. Also the parameters of hyperbolic

  6. Polarization curve analysis of all-vanadium redox flow batteries

    Microsoft Academic Search

    Doug Aaron; Zhijiang Tang; Alexander B. Papandrew; Thomas A. Zawodzinski

    We outline the analysis of performance of redox flow batteries (RFBs) using polarization curves. This method allows the researcher\\u000a immediate access to sources of performance losses in flow batteries operating at steady state. We provide guidance on ‘best\\u000a practices’ for use of this tool, illustrated using examples from single cells operating as vanadium redox batteries.

  7. Extended kindred with recessive late-onset Alzheimer disease maps to locus 8p22-p21.2: a genome-wide linkage analysis.

    PubMed

    Baron, Manuel; Gomez-Tortosa, Estrella; Bochdanovits, Zoltan; Gobernado, Isabel; Rabano, Alberto; Munoz, David G; Heutink, Peter; Jimenez-Escrig, Adriano

    2012-01-01

    Late-onset Alzheimer disease (LOAD) is a complex genetic disorder. Although genes involved in early-onset forms were discovered more than a decade ago, LOAD research has only been able to point out small effect loci, with the exception of APOE. We mapped the gene predisposing to LOAD in an extended inbred family coming from a genetically isolated region (24 sampled individuals, 12 of whom are affected), completing a genome-wide screen with an Affymetrix10 K single nucleotide polymorphism microarray. Genotyping results were evaluated under model-dependent (dominant and recessive) and model-free analysis. We obtained a maximum nonparametric linkage score of 3.24 (P=0.00006) on chromosome 8p22-p21.2. The same genomic position also yielded the highest multipoint heterogeneity LOD (HLOD) under a recessive model (HLOD=3.04). When we compared the results of the model-dependent analysis, a higher score was obtained in the recessive model (3.04) than in the dominant model (1.0). This is a new locus identified in LOAD, in chromosome 8p22-p21.2 and encompassing several candidate genes, among them CLU and PPP3CC that were excluded by sequencing. The finding of a recessive model of inheritance, consistent with the assumption of inbreeding as a morbidity factor in this population, supports the notion of a role of recessive genes in LOAD. PMID:22354140

  8. Molecular Analysis of DMP1 Mutants Causing Autosomal Recessive Hypophosphatemic Rickets

    PubMed Central

    Farrow, Emily G.; Davis, Siobhan I.; Ward, Leanne M.; Summers, Lelia J.; Bubbear, Judith S.; Keen, Richard; Stamp, Trevor C.B.; Baker, Laurence R. I.; Bonewald, Lynda F.; White, Kenneth E.

    2009-01-01

    We previously demonstrated that the mutations Met1Val (M1V) and the deletion of nucleotides 1484-1490 (1484-1490del) in Dentin matrix protein-1 (DMP1) cause the novel disorder autosomal recessive hypophosphatemic rickets (ARHR), which is associated with elevated Fibroblast growth factor-23 (FGF23). To further understand the role of DMP1 in ARHR, we undertook molecular genetic and in vitro expression studies. First, we examined a kindred with a severe hypophosphatemic rickets phenotype and recessive inheritance. Analyses of this family demonstrated that the affected members had elevated serum FGF23 and carried a large, biallelic deletion that removed the majority of DMP1. At a minimum, this deletion encompassed 49 kb between DMP1 exon 3 and an intergenic region 5? to the next telomeric gene, integrin-binding sialoprotein (IBSP). We next performed immunofluorescent studies in cells to understand the effects of the known ARHR mutations on DMP1 cellular processing. These analyses showed that the M1V DMP1 mutant was not sorted to the trans-Golgi network (TGN) and secretory pathway, but filled the entire cytoplasm. In contrast, the 1484-1490del mutant localized to the TGN and was secreted, similar to wild type DMP1. The 1484-1490del mutation replaces the DMP1 18 C-terminal amino acids with 33 non-native residues. Truncation of wild type DMP1 by these native 18 residues followed by Western blot and confocal microscopic analyses demonstrated a wild type expression pattern when compared with the 1484-1490del mutant, indicating that the last 18 residues are not critical for cellular trafficking, but that the 33 additional residues arising from the 1484-1490del mutation likely compromise DMP1 processing. The relationship between DMP1 and FGF23 is unclear. To test endogenous DMP1 response to serum metabolites that also regulate FGF23, UMR-106 cells were treated with 1,25(OH)2 vitamin D (1×10?7M) and showed a 12-fold increase in DMP1 mRNA and protein at 24 hr. In summary, we have identified a novel DMP1 deletion as the cause of ARHR, as well as demonstrated that the ARHR mutations alter DMP1 cellular processing, and that DMP1 can be regulated by vitamin D. Taken together, this work expands our understanding of the genetic and molecular mechanisms associated with DMP1 alterations causing ARHR. PMID:19007919

  9. Comparative proteomic analysis suggests that mitochondria are involved in autosomal recessive polycystic kidney disease.

    PubMed

    Li, Qing-Wei; Lu, Xiao-Yan; You, Yong; Sun, Huan; Liu, Xin-Yu; Ai, Jian-Zhong; Tan, Rui-Zhi; Chen, Tie-Lin; Chen, Mian-Zhi; Wang, Hong-Lian; Wei, Yu-Quan; Zhou, Qin

    2012-08-01

    Autosomal recessive polycystic kidney disease (ARPKD), characterized by ectatic collecting duct, is an infantile form of PKD occurring in 1 in 20 000 births. Despite having been studied for many years, little is known about the underlying mechanisms. In the current study, we employed, for the first time, a MS-based comparative proteomics approach to investigate the differently expressed proteins between kidney tissue samples of four ARPKD and five control individuals. Thirty two differently expressed proteins were identified and six of the identified protein encoding genes performed on an independent group (three ARPKD subjects, four control subjects) were verified by semi-quantitative RT-PCR, and part of them were further validated by Western blot and immunohistochemistry. Moreover, similar alteration tendency was detected after downregulation of PKHD1 by small interfering RNA in HEK293T cell. Interestingly, most of the identified proteins are associated with mitochondria. This implies that mitochondria may be implicated in ARPKD. Furthermore, the String software was utilized to investigate the biological association network, which is based on known and predicted protein interactions. In conclusion, our findings depicted a global understanding of ARPKD progression and provided a promising resource of targeting protein, and shed some light further investigation of ARPKD. PMID:22718539

  10. Linkage analysis of er-1 , a recessive Pisum sativum gene for resistance to powdery mildew fungus ( Erysiphe pisi D.C.)

    Microsoft Academic Search

    G. M. Timmerman; T. J. Frew; N. F. Weeden; A. L. Miller; D. S. Goulden

    1994-01-01

    Linkage analysis was used to determine the genetic map location of er-1, a recessive gene conditioning resistance to powdery mildew, on the Pisum sativum genome. Genetic linkage was demonstrated between er-1 and linkage group 6 markers after analyzing the progeny of two crosses, an F2 population and a set of recombinant inbred lines. The classes of genetic markers surrounding er-1

  11. Exclusion of the locus for autosomal recessive pseudohypoaldosteronism type 1 from the mineralocorticoid receptor gene region on human chromosome 4q by linkage analysis

    SciTech Connect

    Chung, E.; Hanukoglu, A.; Rees, M.; Thompson, R.; Gardiner, R.M. [Univ. College London Medical School, London (United Kingdom)] [and others] [Univ. College London Medical School, London (United Kingdom); and others

    1995-10-01

    Pseudohypoaldosteronism type 1 (PHA1) is an uncommon inherited disorder characterized by salt-wasting in infancy arising from target organ unresponsiveness to mineralocorticoids. Clinical expression of the disease varies from severely affected infants who may die to apparently asymptomatic individuals. Inheritance is Mendelian and may be either autosomal dominant or autosomal recessive. A defect in the mineralocortiocoid receptor has been implicated as a likely cause of PHA1. The gene for human mineralocorticoid receptor (MLR) has been cloned and physically mapped to human chromosome 4q31.1-31.2. The etiological role of MLR in autosomal recessive PHA1 was investigated by performing linkage analysis between PHA1 and three simple sequence length polymorphisms (D4S192, D4S1548, and D4S413) on chromosome 4q in 10 consanguineous families. Linkage analysis was carried out assuming autosomal recessive inheritance with full penetrance and zero phenocopy rate using the MLINK program for two-point analysis and the HOMOZ program for multipoint analysis. Lod scores of less than -2 were obtained over the whole region from D4S192 to D4S413 encompassing MLR. This provides evidence against MLR as the site of mutations causing PHA1 in the majority of autosomal recessive families. 34 refs., 3 figs., 2 tabs.

  12. Stress analysis in curved composites due to thermal loading

    NASA Astrophysics Data System (ADS)

    Polk, Jared Cornelius

    Many structures in aircraft, cars, trucks, ships, machines, tools, bridges, and buildings, consist of curved sections. These sections vary from straight line segments that have curvature at either one or both ends, segments with compound curvatures, segments with two mutually perpendicular curvatures or Gaussian curvatures, and segments with a simple curvature. With the advancements made in multi-purpose composites over the past 60 years, composites slowly but steadily have been appearing in these various vehicles, compound structures, and buildings. These composite sections provide added benefits over isotropic, polymeric, and ceramic materials by generally having a higher specific strength, higher specific stiffnesses, longer fatigue life, lower density, possibilities in reduction of life cycle and/or acquisition cost, and greater adaptability to intended function of structure via material composition and geometry. To be able to design and manufacture a safe composite laminate or structure, it is imperative that the stress distributions, their causes, and effects are thoroughly understood in order to successfully accomplish mission objectives and manufacture a safe and reliable composite. The objective of the thesis work is to expand upon the knowledge of simply curved composite structures by exploring and ascertaining all pertinent parameters, phenomenon, and trends in stress variations in curved laminates due to thermal loading. The simply curved composites consist of composites with one radius of curvature throughout the span of the specimen about only one axis. Analytical beam theory, classical lamination theory, and finite element analysis were used to ascertain stress variations in a flat, isotropic beam. An analytical method was developed to ascertain the stress variations in an isotropic, simply curved beam under thermal loading that is under both free-free and fixed-fixed constraint conditions. This is the first such solution to Author's best knowledge of such a problem. It was ascertained and proven that the general, non-modified (original) version of classical lamination theory cannot be used for an analytical solution for a simply curved beam or any other structure that would require rotations of laminates out their planes in space. Finite element analysis was used to ascertain stress variations in a simply curved beam. It was verified that these solutions reduce to the flat beam solutions as the radius of curvature of the beams tends to infinity. MATLAB was used to conduct the classical lamination theory numerical analysis. A MATLAB program was written to conduct the finite element analysis for the flat and curved beams, isotropic and composite. It does not require incompatibility techniques used in mechanics of isotropic materials for indeterminate structures that are equivalent to fixed-beam problems. Finally, it has the ability to enable the user to define and create unique elements not accessible in commercial software, and modify finite element procedures to take advantage of new paradigms.

  13. Estimated hydrologic characteristics of shallow aquifer systems in the Valley and Ridge, the Blue Ridge, and the Piedmont physiographic provinces based on analysis of streamflow recession and base flow

    USGS Publications Warehouse

    Rutledge, A.T.; Mesko, T.O.

    1996-01-01

    Inferences are drawn about properties of aquifer systems from the interpretation of streamflow records in the Appalachian Valley and Ridge, Piedmont, and Blue Ridge physiographic provinces. The analysis is divided into two parts--analysis of streamflow recession and base-flow analysis. Analysis of recession yields information about aquifer diffusivity and variation in specific yield. Base-flow analysis is used to develop water balances for representative basins in the study area.

  14. Dissection of the Hormetic Curve: Analysis of Components and Mechanisms

    PubMed Central

    Lushchak, Volodymyr I.

    2014-01-01

    The relationship between the dose of an effector and the biological response frequently is not described by a linear function and, moreover, in some cases the dose-response relationship may change from positive/adverse to adverse/positive with increasing dose. This complicated relationship is called “hormesis”. This paper provides a short analysis of the concept along with a description of used approaches to characterize hormetic relationships. The whole hormetic curve can be divided into three zones: I – a lag-zone where no changes are observed with increasing dose; II – a zone where beneficial/adverse effects are observed, and III – a zone where the effects are opposite to those seen in zone II. Some approaches are proposed to analyze the molecular components involved in the development of the hormetic character of dose-response relationships with the use of specific genetic lines or inhibitors of regulatory pathways. The discussion is then extended to suggest a new parameter (half-width of the hormetic curve at zone II) for quantitative characterization of the hormetic curve. The problems limiting progress in the development of the hormesis concept such as low reproducibility and predictability may be solved, at least partly, by deciphering the molecular mechanisms underlying the hormetic dose-effect relationship. PMID:25249836

  15. An analysis of the shapes of ultraviolet extinction curves. III - An atlas of ultraviolet extinction curves

    NASA Technical Reports Server (NTRS)

    Fitzpatrick, Edward L.; Massa, Derck

    1990-01-01

    The basic data needed to produce UV extinction curves for a sample of 78 stars, including spectral types, visual photometry, parameters used to produce fits to the UV extinction curves, distances to the program stars, and line-of-sight H I column densities, are presented. The observational and numerical techniques used to obtain the results are discussed in detail. The UV extinction curves and their analytic fits are shown graphically.

  16. Comparison of Simple Power Analysis Attack Resistant Algorithms for an Elliptic Curve

    E-print Network

    Paris-Sud XI, Université de

    -- Cryptography, ellitipic curves, side channel attacks, scheduling techniques I. INTRODUCTION Elliptic curve in the difficulty of an encryption schemes inverse operation. Elliptic curve cryptography provides relatively betterComparison of Simple Power Analysis Attack Resistant Algorithms for an Elliptic Curve Cryptosystem

  17. Tradeoff analysis of FPGA based elliptic curve cryptography

    Microsoft Academic Search

    Marcus Bednara; M. Daldrup; Jürgen Teich; Joachim Von Zur Gathen; Jamshid Shokrollahi

    2002-01-01

    FPGAs are an attractive platform for elliptic curve cryptography hardware. Since field multiplication is the most critical operation in elliptic curve cryptography, we have studied how efficient sev- eral field multipliers can be mapped to lookup table based FPGAs. Furthermore we have compared different curve coordinate repre- sentations with respect to the number of required field operations, and show how

  18. Concentrated photovoltaics system costs and learning curve analysis

    NASA Astrophysics Data System (ADS)

    Haysom, Joan E.; Jafarieh, Omid; Anis, Hanan; Hinzer, Karin

    2013-09-01

    An extensive set of costs in /W for the installed costs of CPV systems has been amassed from a range of public sources, including both individual company prices and market reports. Cost reductions over time are very evident, with current prices for 2012 in the range of 3.0 ± 0.7 /W and a predicted cost of 1.5 /W for 2020. Cost data is combined with deployment volumes in a learning curve analysis, providing a fitted learning rate of either 18.5% or 22.3% depending on the methodology. This learning rate is compared to that of PV modules and PV installed systems, and the influence of soft costs is discussed. Finally, if an annual growth rate of 39% is assumed for deployed volumes, then, using the learning rate of 20%, this would predict the achievement of a cost point of 1.5 /W by 2016.

  19. Three-dimensional forward solver and its performance analysis for magnetic resonance electrical impedance tomography (MREIT) using recessed electrodes

    Microsoft Academic Search

    Byung Il Lee; Suk Hoon Oh; Eung Je Woo; Soo Yeol Lee; Min Hyoung Cho; Ohin Kwon; Jin Keun Seo; June-Yub Lee; Woon Sik Baek

    2003-01-01

    In magnetic resonance electrical impedance tomography (MREIT), we try to reconstruct a cross-sectional resistivity (or conductivity) image of a subject. When we inject a current through surface electrodes, it generates a magnetic field. Using a magnetic resonance imaging (MRI) scanner, we can obtain the induced magnetic flux density from MR phase images of the subject. We use recessed electrodes to

  20. Estimating basin-wide hydraulic parameters of a semi-arid mountainous watershed by recession-flow analysis

    E-print Network

    Walter, M.Todd

    Estimating basin-wide hydraulic parameters of a semi-arid mountainous watershed by recession 2002; accepted 23 April 2003 Abstract Insufficient sub-surface hydraulic data from watersheds often and in watersheds with low population densities because well-drilling to obtain the hydraulic data is expensive

  1. On the Design and Analysis of Modified Koch Curve Fractal Antenna

    NASA Astrophysics Data System (ADS)

    Rani, S.; Singh, A. P.

    2013-12-01

    A comparative study of the conventional and modified Koch curve antennas has been analyzed. The geometries of the antennas are obtained by an iterative function system algorithm for fractal curve generation. It has been observed that by keeping height and width of curve constant the modified Koch curve antenna provide more resonant frequencies with better return loss in comparison with conventional Koch curve antenna. The presented analysis quantifies the advantages provided by the modified Koch curve antenna and is validated by simulations and experimental results.

  2. Hybrid analytical technique for the nonlinear analysis of curved beams

    NASA Technical Reports Server (NTRS)

    Noor, A. K.; Andersen, C. M.

    1992-01-01

    The application of a two-step hybrid technique to the geometrically nonlinear analysis of curved beams is used to demonstrate the potential of hybrid analytical techniques in nonlinear structural mechanics. The hybrid technique is based on successive use of the perturbation method and a classical direct variational procedure. The functions associated with the various-order terms in the perturbation expansion of the fundamental unknowns, and their sensitivity derivatives with respect to material and geometric parameters of the beam, are first obtained by using the perturbation method. These functions are selected as coordinate functions (or modes) and the classical direct variational technique is then used to compute their amplitudes. The potential of the proposed hybrid technique for nonlinear analysis of structures is discussed. The effectiveness of the hybrid technique is demonstrated by means of numerical examples. The symbolic computation system Mathematica is used in the present study. The tasks performed on Mathematica include: (1) generation of algebraic expressions for the perturbation functions of the different response quantities and their sensitivity derivatives: and (2) determination of the radius of convergence of the perturbation series.

  3. Descriptive and Predictive Growth Curves in Energy System Analysis

    Microsoft Academic Search

    Mikael Höök; Junchen Li; Noriaki Oba; Simon Snowden

    2011-01-01

    This study reviews a variety of growth curve models and the theoretical frameworks that lay behind them. In many systems,\\u000a growth patterns are, or must, ultimately be subjected to some form of limitation. A number of curve models have been developed\\u000a to describe and predict such behaviours. Symmetric growth curves have frequently been used for forecasting fossil fuel production,\\u000a but

  4. Recess Makes Kids Smarter

    ERIC Educational Resources Information Center

    Adams, Caralee

    2011-01-01

    Recess has been scaled back or cut altogether in a number of schools around the country. The trend can be traced back to the late eighties and was accelerated under No Child Left Behind. Districts under pressure to show academic progress began to squeeze as much instruction into the day as possible. Others eliminated recess because of concerns…

  5. Recess--It's Indispensable!

    ERIC Educational Resources Information Center

    Jarrett, Olga; Waite-Stupiansky, Sandra

    2009-01-01

    The demise of recess in many elementary schools--and of outdoor play in general--is an issue of great concern to many members of the Play, Policy, and Practice Interest Forum. Most people remember recess as an important part of the school day. It was a time to be outdoors; to organize games; to play on the swings, slides, and other playground…

  6. Straight thinking about groundwater recession

    NASA Astrophysics Data System (ADS)

    Cuthbert, M. O.

    2014-03-01

    While in catchment and hillslope hydrology a more nuanced approach is now taken to streamflow recession analysis, in the context of major aquifers it is commonly still assumed that the groundwater head recession rate will take exponential form, an idea originally proposed in the 19th Century. However it is shown here that, in early times, the groundwater head recession in a major aquifer should take an almost straight line form with a rate approximately equal to the long-term recharge rate divided by the aquifer storage coefficient. The length of this phase can be estimated from an analytical expression derived in the paper which depends on the aquifer diffusivity, length scale, and the position of the monitoring point. A transitional phase then leads to an exponential phase after some critical time which is independent of the position of the monitoring point. Major aquifers in a state of periodic quasi-steady state are expected to have rates of groundwater flux recession which deviate little from the average rate of groundwater recharge. Where quasi-exponential groundwater declines are observed in nature, their form may be diagnostic of particular types of aquifer properties and/or boundary effects, such as proximity to drainage boundaries, variations in transmissivity with hydraulic head, storage changes due to pumping, nonequilibrium flow at a range of spatial and temporal scales, and variations in specific yield with depth. Recession analysis has applicability to a range of groundwater problems and is powerful way of gaining insight into the hydrologic functioning of an aquifer.

  7. Outcome of ABCA4 disease-associated alleles in autosomal recessive Retinal Dystrophies: Retrospective analysis in 420 Spanish families

    PubMed Central

    Riveiro-Alvarez, Rosa; Lopez-Martinez, Miguel-Angel; Zernant, Jana; Aguirre-Lamban, Jana; Cantalapiedra, Diego; Avila-Fernandez, Almudena; Gimenez, A.; Lopez-Molina, Maria-Isabel; Garcia-Sandoval, Blanca; Blanco-Kelly, Fiona; Corton, Marta; Tatu, Sorina; Jose, Patricia Fernandez-San; Trujillo-Tiebas, Maria-Jose; Ramos, Carmen; Allikmets, Rando; Ayuso, Carmen

    2013-01-01

    Objective To provide a comprehensive overview of all detected mutations in the ABCA4 gene in Spanish families with autosomal recessive retinal disorders, including Stargardt disease (arSTGD), cone-rod dystrophy (arCRD), and retinitis pigmentosa (arRP). Also, to assess genotype-phenotype correlation and disease progression in 10 years by considering type of variants and age of onset. Design Case series. Participants A total of 420 unrelated Spanish families: 259 arSTGD, 86 arCRD and 75 arRP. Methods Spanish families were analysed through a combination of ABCR400 genotyping microarray, denaturing High-Performance Liquid Chromatography (dHPLC) and High Resolution Melting (HRM) scanning. Direct sequencing was used as confirmation technique for the identified variants. Screening by Multiple Ligation Probe Analysis (MLPA) was used in order to detect possible large deletions or insertions in the ABCA4 gene. Selected families were further analysed by Next Generation Sequencing (NGS). Main Outcome Measures DNA sequence variants, mutation detection rates, haplotypes, age of onset, central or peripheral vision loss, night blindness. Results Overall, we detected 70.5% and 36.6% of all expected ABCA4 mutations in arSTGD and arCRD patient cohorts, respectively. In the fraction of the cohort where the ABCA4 gene was completely sequenced the detection rates reached 73.6% for STGD and 66.7% for CRD. However, the frequency of possibly pathogenic ABCA4 alleles in arRP families was only slightly higher to that in the general population. Moreover, in some families mutations in other known arRP genes segregated with the disease phenotype. Conclusions An increasing understanding of causal ABCA4 alleles in arSTGD and arCRD facilitates disease diagnosis and prognosis and is also paramount in selecting patients for emerging clinical trials of therapeutic interventions. As ABCA4-associated diseases are evolving retinal dystrophies, assessment of age of onset, accurate clinical diagnosis and genetic testing are crucial. We suggest that ABCA4 mutations may be associated with an RP-like phenotype often as a consequence of severe (null) mutations and/or in cases of long-term, advanced disease. Patients with “classical” arRP phenotypes, especially from the onset of the disease, should be first screened for mutations in known arRP genes and not ABCA4. PMID:23755871

  8. Decline curve analysis predicts oil recovery from horizontal wells

    Microsoft Academic Search

    P. N. Mutalik; S. D. Joshi

    1992-01-01

    This paper reports that for the transient and post-transient decline periods of a horizontal well in a bounded reservoir, an analytical model has been developed that can forecast recoverable reserves. This decline curve method predicts future performance of both new and existing horizontal wells. The model can also be used to develop horizontal well type curves. Two key issues in

  9. What mainly controls recession flows in river basins?

    NASA Astrophysics Data System (ADS)

    Biswal, Basudev; Nagesh Kumar, D.

    2014-03-01

    The ubiquity of the power law relationship between dQ/dt and Q for recession periods (-dQ/dt=kQ?,Q being discharge at the basin outlet at time t) clearly hints at the existence of a dominant recession flow process that is common to all real basins. It is commonly assumed that a basin, during recession events, functions as a single phreatic aquifer resting on a impermeable horizontal bed or the Dupuit-Boussinesq (DB) aquifer, and with time different aquifer geometric conditions arise that give different values of ? and k. The recently proposed alternative model, geomorphological recession flow model, however, suggests that recession flows are controlled primarily by the dynamics of the active drainage network (ADN). In this study we use data for several basins and compare the above two contrasting recession flow models in order to understand which of the above two factors dominates during recession periods in steep basins. Particularly, we do the comparison by selecting three key recession flow properties: (1) power law exponent ?, (2) dynamic dQ/dt-Q relationship (characterized by k) and (3) recession timescale (time period for which a recession event lasts). Our observations suggest that neither drainage from phreatic aquifers nor evapotranspiration significantly controls recession flows. Results show that the value of ? and recession timescale are not modeled well by DB aquifer model. However, the above mentioned three recession curve properties can be captured satisfactorily by considering the dynamics of the ADN as described by geomorphological recession flow model, possibly indicating that the ADN represents not just phreatic aquifers but the organization of various sub-surface storage systems within the basin.

  10. Location of the recessive gene ym (yellow margin) on chromosome 12 of diploid Solatium tuberosum by means of trisomic analysis

    Microsoft Academic Search

    M. Wagenvoort

    1982-01-01

    Ten out of twelve primary trisomics of dip-loid S. tuberosum were crossed as females with a recessive mutant for yellow margin (ym ym) obtained from S. phureja. All primary trisomics used proved to be homozygous dominant. Trisomic plants from all ten F1's were backcrossed with the mutant and trisomics from eight F1's were crossed also with a disomic heterozygous f1

  11. Analysis of patient acceptance following treatment of Miller's class II gingival recession with acellular dermal matrix and connective tissue graft

    PubMed Central

    Goyal, Niti; Gupta, Rajan; Pandit, Nymphea; Dahiya, Parveen

    2014-01-01

    Objective: Obtaining predictable and aesthetic root coverage has become an important part of periodontal therapy. The search for the appropriate root coverage techniques has resulted in many different approaches. The goal of this study was to evaluate the degree of patient acceptance with acellular dermal matrix (ADM) allograft in the treatment of buccal gingival recession and to compare it with subepithelial connective tissue graft. Materials and Methods: Thirty patients with Miller's class II recessions were treated and randomly assigned to the test group (ADM) and control group (subepithelial connective tissue graft). All patients underwent full periodontal evaluation and pre-surgical preparation, including oral hygiene instructions and scaling and root planing. The exposed roots were thoroughly planed and covered by a graft without any further root treatment. Results were evaluated based on the parameters measuring patient satisfaction and clinical outcome after 6 months of the surgical procedure. Results: Postoperatively, significant root coverage, reduction in probing depth, gain in clinical attachment level, and increase in widths of keratinized tissue and attached gingiva were observed on intra-group comparison. There was no significant difference in any of the parameters between test and control groups. Conclusion: The subepithelial connective tissue graft and ADM graft were able to successfully treat gingival recession defects; however, the ADM showed better patient acceptance than the connective tissue graft. PMID:25024550

  12. Three-Dimensional Postbuckling Analysis of Curved Beams

    NASA Technical Reports Server (NTRS)

    Pai, P. Frank; Lee, Seung-Yoon

    2002-01-01

    Presented here is a method of solving highly flexible curved beam undergoing huge static or quasi-static deformations. A geometrically exact beam theory based on the use of Jaumann stresses and strains and exact coordinate transformation is presented in terms of 17 first-order ordinary differential equations, and a multiple shooting method is used to solve the corresponding nonlinear two-point boundary value problems. The geometrically exact beam theory accounts far large rotations, large displacements, initial curvatures, extensionality, and transverse shear strains. Four examples are used to demonstrate this method, including a rotating clamped-free beam under the influence of gravity and centrifugal forces, an L-frame subjected to an in-plane tip load, a circular arch subjected to a concentrated load, and a clamped-hinged helical spring subjected to an axial displacement. Results show that the combination of the multiple shooting method and the geometrically exact beam theory works very well. Moreover, the obtained numerically exact solutions can be used to verify the accuracy of nonlinear finite element codes for nonlinear analysis of complex structures.

  13. [Analysis of dominant and recessive sex-linked lethal mutations induced by low radiation doses in genetically different strains of Drosophila melanogaster w and MS].

    PubMed

    Aslanian, M M; Kim, A I; Magomedova, M A; Fatkulbaianova, N L

    1994-09-01

    Frequencies of induced recessive sex-linked lethal mutations (RSLLM) and dominant lethal mutations (DLM) were analyzed in genetically different Drosophila melanogaster strains w and ms after their exposure to radiation on radioactive soil in laboratory conditions. The RSLLM test applied to males after their 14-day radiation exposure yielded controversial results. An analysis of induced and spontaneous DLM demonstrated an increase in the frequency of early embryonic lethal mutations in the experiment (radiation exposure) in comparison with the control (spontaneous mutation rate) in both strains examined. PMID:8001805

  14. Comparison of Emperical Decline Curve Analysis for Shale Wells

    E-print Network

    Kanfar, Mohammed Sami

    2013-07-13

    This study compares four recently developed decline curve methods and the traditional Arps or Fetkovich approach. The four methods which are empirically formulated for shale and tight gas wells are: 1. Power Law Exponential Decline (PLE). 2...

  15. Automatic generation and analysis of solar cell IV curves

    SciTech Connect

    Kraft, Steven M.; Jones, Jason C.

    2014-06-03

    A photovoltaic system includes multiple strings of solar panels and a device presenting a DC load to the strings of solar panels. Output currents of the strings of solar panels may be sensed and provided to a computer that generates current-voltage (IV) curves of the strings of solar panels. Output voltages of the string of solar panels may be sensed at the string or at the device presenting the DC load. The DC load may be varied. Output currents of the strings of solar panels responsive to the variation of the DC load are sensed to generate IV curves of the strings of solar panels. IV curves may be compared and analyzed to evaluate performance of and detect problems with a string of solar panels.

  16. New method for calculating a mathematical expression for streamflow recession

    USGS Publications Warehouse

    Rutledge, Albert T.

    1991-01-01

    An empirical method has been devised to calculate the master recession curve, which is a mathematical expression for streamflow recession during times of negligible direct runoff. The method is based on the assumption that the storage-delay factor, which is the time per log cycle of streamflow recession, varies linearly with the logarithm of streamflow. The resulting master recession curve can be nonlinear. The method can be executed by a computer program that reads a data file of daily mean streamflow, then allows the user to select several near-linear segments of streamflow recession. The storage-delay factor for each segment is one of the coefficients of the equation that results from linear least-squares regression. Using results for each recession segment, a mathematical expression of the storage-delay factor as a function of the log of streamflow is determined by linear least-squares regression. The master recession curve, which is a second-order polynomial expression for time as a function of log of streamflow, is then derived using the coefficients of this function.

  17. Trends in population mental health before and after the 2008 recession: a repeat cross-sectional analysis of the 1991–2010 Health Surveys of England

    PubMed Central

    Katikireddi, Srinivasa Vittal; Niedzwiedz, Claire L; Popham, Frank

    2012-01-01

    Objective To assess short-term differences in population mental health before and after the 2008 recession and explore how and why these changes differ by gender, age and socio-economic position. Design Repeat cross-sectional analysis of survey data. Setting England. Participants Representative samples of the working age (25–64?years) general population participating in the Health Survey for England between 1991 and 2010 inclusive. Main outcome measures Prevalence of poor mental health (caseness) as measured by the general health questionnaire-12 (GHQ). Results Age–sex standardised prevalence of GHQ caseness increased from 13.7% (95% CI 12.9% to 14.5%) in 2008 to 16.4% (95% CI 14.9% to 17.9%) in 2009 and 15.5% (95% CI 14.4% to 16.7%) in 2010. Women had a consistently greater prevalence since 1991 until the current recession. However, compared to 2008, men experienced an increase in age-adjusted caseness of 5.1% (95% CI 2.6% to 7.6%, p<0.001) in 2009 and 3% (95% CI 1.2% to 4.9%, p=0.001) in 2010, while no statistically significant changes were seen in women. Adjustment for differences in employment status and education level did not account for the observed increase in men nor did they explain the differential gender patterning. Over the last decade, socio-economic inequalities showed a tendency to increase but no clear evidence for an increase in inequalities associated with the recession was found. Similarly, no evidence was found for a differential effect between age groups. Conclusions Population mental health in men has deteriorated within 2?years of the onset of the current recession. These changes, and their patterning by gender, could not be accounted for by differences in employment status. Further work is needed to monitor recessionary impacts on health inequalities in response to ongoing labour market and social policy changes. PMID:23075569

  18. Performance curves of a series DC motor predicted using parametric finite element analysis

    SciTech Connect

    Ebben, R.N. (Milwaukee Electric Tool Corp., Brookfield, WI (United States)); Brauer, J.R.; Lizalek, G.C.; Cendes, Z.J. (Ansoft Corp., Pittsburgh, PA (United States))

    1999-05-01

    Direct-current motors with brushes are commonly used for portable tools and other appliances. A procedure is derived that uses finite element analysis to predict the performance curves of a typical series dc motor. A number of different analyses are made with parametric variations of current and rotor position. The computed torque-speed and current-speed curves are shown to agree closely with the measured curves.

  19. Performance analysis of elliptic curve cryptography for SSL

    Microsoft Academic Search

    Vipul Gupta; Sumit Gupta; Sheueling Chang; Douglas Stebila

    2002-01-01

    Elliptic Curve Cryptography (ECC) is emerging as an attractive public-key cryptosystem for mobile\\/wireless environments. Compared to traditional cryptosystems like RSA, ECC offers equivalent security with smaller key sizes, which results in faster computations, lower power consumption, as well as memory and bandwidth savings. This is especially useful for mobile devices which are typically limited in terms of their CPU, power

  20. Nonlinear thermoelastic stress analysis of spherically curved solar panels

    Microsoft Academic Search

    C. V. G. Vallabhan; K. Vungutur; R. P. Selvam

    1984-01-01

    Spherically curved glass panels are used to concentrate solar energy onto a line focus in fixed mirror distributed focus type solar collectors. These solar panels consists of thin flat glass plates bent to form a spherical surface, glued onto a paper honeycomb backing, and covered with steel plate at the back and with plastic strips on the sides. Stresses are

  1. Use of the Zoom in the Analysis of a Curve.

    ERIC Educational Resources Information Center

    Montaner, F. Rubio

    1987-01-01

    How the computer can aid the teacher in discussing plane curves is shown. Use of the zoom enables the teacher to illustrate aspects of graphs that would be difficult and time-consuming to show in other ways. Many illustrative graphs are included, and four programs are listed. (MNS)

  2. Unsupervised Transient Light Curve Analysis via Hierarchical Bayesian Inference

    NASA Astrophysics Data System (ADS)

    Sanders, N. E.; Betancourt, M.; Soderberg, A. M.

    2015-02-01

    Historically, light curve studies of supernovae (SNe) and other transient classes have focused on individual objects with copious and high signal-to-noise observations. In the nascent era of wide field transient searches, objects with detailed observations are decreasing as a fraction of the overall known SN population, and this strategy sacrifices the majority of the information contained in the data about the underlying population of transients. A population level modeling approach, simultaneously fitting all available observations of objects in a transient sub-class of interest, fully mines the data to infer the properties of the population and avoids certain systematic biases. We present a novel hierarchical Bayesian statistical model for population level modeling of transient light curves, and discuss its implementation using an efficient Hamiltonian Monte Carlo technique. As a test case, we apply this model to the Type IIP SN sample from the Pan-STARRS1 Medium Deep Survey, consisting of 18,837 photometric observations of 76 SNe, corresponding to a joint posterior distribution with 9176 parameters under our model. Our hierarchical model fits provide improved constraints on light curve parameters relevant to the physical properties of their progenitor stars relative to modeling individual light curves alone. Moreover, we directly evaluate the probability for occurrence rates of unseen light curve characteristics from the model hyperparameters, addressing observational biases in survey methodology. We view this modeling framework as an unsupervised machine learning technique with the ability to maximize scientific returns from data to be collected by future wide field transient searches like LSST.

  3. The recessive model of MRP2 G1249A polymorphism decrease the risk of drug-resistant in Asian Epilepsy: A systematic review and meta-analysis.

    PubMed

    Wang, Yan; Tang, Liang; Pan, Jiabao; Li, Jianming; Zhang, Qingsong; Chen, Bifeng

    2015-05-01

    ABCC2 gene polymorphisms have been shown to be associated with drug-resistant epilepsy. However, the published results were controversial. To comprehensively re-evaluate the association between ABCC2 gene polymorphisms and drug-resistant epilepsy in Asian, we carried out this meta-analysis, which included eight related studies. Studies were selected using PUBMED, Web of science, the Cochrane database of system reviews and Embase. Pooled odds ratio (OR) with 95% confidence interval (CI) was used to assess the association. Studies with 1302 drug-resistant cases and 1563 drug-sensitive controls were included. No significant association was detected by combined analyses for C-24T, G-1774delG, C3972T and G2934A. However, significant association was found in recessive model for G1249A polymorphism (GG vs. GA+AA: OR=0.72, 95%CI=0.53-0.96, P=0.03), indicating the recessive model of G1249A in MRP2/ABCC2 might decrease the risk of drug resistance in Asian epilepsy. PMID:25847339

  4. Evolutionary-algorithm-based analysis of gravitational microlensing light curves

    NASA Astrophysics Data System (ADS)

    Rajpaul, V.

    2012-12-01

    A new algorithm developed to perform autonomous fitting of gravitational microlensing light curves is presented. The new algorithm is conceptually simple, versatile and robust, and parallelizes trivially; it combines features of extant evolutionary algorithms with some novel ones, and fares well on the problem of fitting binary-lens microlensing light curves, as well as on a number of other difficult optimization problems. Success rates in excess of 90 per cent are achieved when fitting synthetic though noisy binary-lens light curves, allowing no more than 20 min per fit on a desktop computer; this success rate is shown to compare very favourably with that of both a conventional (iterated simplex) algorithm, and a more state-of-the-art, artificial neural network based approach. As such, this work provides proof of concept for the use of an evolutionary algorithm as the basis for real-time, autonomous modelling of microlensing events. Further work is required to investigate how the algorithm will fare when faced with more complex and realistic microlensing modelling problems; it is, however, argued here that the use of parallel computing platforms, such as inexpensive graphics processing units, should allow fitting times to be constrained to under an hour, even when dealing with complicated microlensing models. In any event, it is hoped that this work might stimulate some interest in evolutionary algorithms, and that the algorithm described here might prove useful for solving microlensing and/or more general model-fitting problems.

  5. Thermoluminescence glow curve analysis of natural onyx from Turkey.

    PubMed

    Dogan, Tamer; Toktam??, Hüseyin; Yüksel, Mehmet; Topaksu, Mustafa; Yazici, A Necmeddin

    2015-02-01

    In this study, the thermoluminesce (TL) properties of natural onyx were determined after ?-irradiation ((90)Sr/(90)Y) at room temperature. The effect of the additive dose and variable heating rate for TL glow peaks of the sample were investigated. Computerized glow curve deconvolution (CGCD) methods were used to determine the number of peaks and kinetic parameters related to the TL glow peaks in natural onyx from Turkey. It was also determined kinetic parameters of onyx by means of the variable heating rate (VHR) method. The sample was exposed to ?-irradiation between 2.4 Gy and 2.457 kGy. The CGCD methods showed that the glow curve of sample is the superposition of at least six first order components which were ascribed as P1-P6. The dose responses of some peaks have similar patterns and they follow linearity. The effect of heating rates on the response of dosimetric glow peaks of sample was studied. The maximum TL peak intensities of glow curve are decreasing with increasing heating rate and maximum TL peak intensities at 1 °C/s drops to 20% of the initial value when the sample is read at 6 °C/s. PMID:25474767

  6. Global Analysis of KOI-977: Spectroscopy, Asteroseismology, and Phase-curve Analysis

    NASA Astrophysics Data System (ADS)

    Hirano, Teruyuki; Masuda, Kento; Sato, Bun'ei; Benomar, Othman; Takeda, Yoichi; Omiya, Masashi; Harakawa, Hiroki; Kobayashi, Atsushi

    2015-01-01

    We present a global analysis of KOI-977, one of the planet host candidates detected by Kepler. The Kepler Input Catalog (KIC) reports that KOI-977 is a red giant, for which few close-in planets have been discovered. Our global analysis involves spectroscopic and asteroseismic determinations of stellar parameters (e.g., mass and radius) and radial velocity (RV) measurements. Our analyses reveal that KOI-977 is indeed a red giant, possibly in the red clump, but its estimated radius (gsim 20 R ? = 0.093 AU) is much larger than KOI-977.01's orbital distance (~0.027 AU) estimated from its period (P orb ~ 1.35 days) and host star's mass. RV measurements show a small variation, which also contradicts the amplitude of ellipsoidal variations seen in the light curve folded with KOI-977.01's period. Therefore, we conclude that KOI-977.01 is a false positive, meaning that the red giant, for which we measured the radius and RVs, is different from the object that produces the transit-like signal (i.e., an eclipsing binary). On the basis of this assumption, we also perform a light curve analysis including the modeling of transits/eclipses and phase-curve variations, adopting various values for the dilution factor D, which is defined as the flux ratio between the red giant and eclipsing binary. Fitting the whole folded light curve as well as individual transits in the short cadence data simultaneously, we find that the estimated mass and radius ratios of the eclipsing binary are consistent with those of a solar-type star and a late-type star (e.g., an M dwarf) for D >~ 20.

  7. M dwarfs in Sloan Digital Sky Survey Stripe 82: Photometric light curves and flare rate analysis

    E-print Network

    Kowalski, Adam F.

    We present a flare rate analysis of 50,130 M dwarf light curves in Sloan Digital Sky Survey Stripe 82. We identified 271 flares using a customized variability index to search ~2.5 million photometric observations for flux ...

  8. Transit Light Curves with Finite Integration Time: Fisher Information Analysis

    NASA Astrophysics Data System (ADS)

    Price, Ellen M.; Rogers, Leslie A.

    2014-10-01

    Kepler has revolutionized the study of transiting planets with its unprecedented photometric precision on more than 150,000 target stars. Most of the transiting planet candidates detected by Kepler have been observed as long-cadence targets with 30 minute integration times, and the upcoming Transiting Exoplanet Survey Satellite will record full frame images with a similar integration time. Integrations of 30 minutes affect the transit shape, particularly for small planets and in cases of low signal to noise. Using the Fisher information matrix technique, we derive analytic approximations for the variances and covariances on the transit parameters obtained from fitting light curve photometry collected with a finite integration time. We find that binning the light curve can significantly increase the uncertainties and covariances on the inferred parameters when comparing scenarios with constant total signal to noise (constant total integration time in the absence of read noise). Uncertainties on the transit ingress/egress time increase by a factor of 34 for Earth-size planets and 3.4 for Jupiter-size planets around Sun-like stars for integration times of 30 minutes compared to instantaneously sampled light curves. Similarly, uncertainties on the mid-transit time for Earth and Jupiter-size planets increase by factors of 3.9 and 1.4. Uncertainties on the transit depth are largely unaffected by finite integration times. While correlations among the transit depth, ingress duration, and transit duration all increase in magnitude with longer integration times, the mid-transit time remains uncorrelated with the other parameters. We provide code in Python and Mathematica for predicting the variances and covariances at www.its.caltech.edu/~eprice.

  9. A general geomorphological recession flow model for river basins

    NASA Astrophysics Data System (ADS)

    Biswal, Basudev; Nagesh Kumar, D.

    2013-08-01

    Recession flows in a basin are controlled by the temporal evolution of its active drainage network (ADN). The geomorphological recession flow model (GRFM) assumes that both the rate of flow generation per unit ADN length (q) and the speed at which ADN heads move downstream (c) remain constant during a recession event. Thereby, it connects the power law exponent of -dQ/dt versus Q (discharge at the outlet at time t) curve, ?, with the structure of the drainage network, a fixed entity. In this study, we first reformulate the GRFM for Horton-Strahler networks and show that the geomorphic ? (?g) is equal to D/>(D-1>), where D is the fractal dimension of the drainage network. We then propose a more general recession flow model by expressing both q and c as functions of Horton-Strahler stream order. We show that it is possible to have ? =? g for a recession event even when q and c do not remain constant. The modified GRFM suggests that ? is controlled by the spatial distribution of subsurface storage within the basin. By analyzing streamflow data from 39 U.S. Geological Survey basins, we show that ? is having a power law relationship with recession curve peak, which indicates that the spatial distribution of subsurface storage varies across recession events.

  10. A Brief Review: The Z-curve Theory and its Application in Genome Analysis

    PubMed Central

    Zhang, Ren; Zhang, Chun-Ting

    2014-01-01

    In theoretical physics, there exist two basic mathematical approaches, algebraic and geometrical methods, which, in most cases, are complementary. In the area of genome sequence analysis, however, algebraic approaches have been widely used, while geometrical approaches have been less explored for a long time. The Z-curve theory is a geometrical approach to genome analysis. The Z-curve is a three-dimensional curve that represents a given DNA sequence in the sense that each can be uniquely reconstructed given the other. The Z-curve, therefore, contains all the information that the corresponding DNA sequence carries. The analysis of a DNA sequence can then be performed through studying the corresponding Z-curve. The Z-curve method has found applications in a wide range of areas in the past two decades, including the identifications of protein-coding genes, replication origins, horizontally-transferred genomic islands, promoters, translational start sides and isochores, as well as studies on phylogenetics, genome visualization and comparative genomics. Here, we review the progress of Z-curve studies from aspects of both theory and applications in genome analysis. PMID:24822026

  11. Three-dimensional forward solver and its performance analysis for magnetic resonance electrical impedance tomography (MREIT) using recessed electrodes.

    PubMed

    Lee, Byung Il; Oh, Suk Hoon; Woo, Eung Je; Lee, Soo Yeol; Cho, Min Hyoung; Kwon, Ohin; Seo, Jin Keun; Lee, June-Yub; Baek, Woon Sik

    2003-07-01

    In magnetic resonance electrical impedance tomography (MREIT), we try to reconstruct a cross-sectional resistivity (or conductivity) image of a subject. When we inject a current through surface electrodes, it generates a magnetic field. Using a magnetic resonance imaging (MRI) scanner, we can obtain the induced magnetic flux density from MR phase images of the subject. We use recessed electrodes to avoid undesirable artefacts near electrodes in measuring magnetic flux densities. An MREIT image reconstruction algorithm produces cross-sectional resistivity images utilizing the measured internal magnetic flux density in addition to boundary voltage data. In order to develop such an image reconstruction algorithm, we need a three-dimensional forward solver. Given injection currents as boundary conditions, the forward solver described in this paper computes voltage and current density distributions using the finite element method (FEM). Then, it calculates the magnetic flux density within the subject using the Biot-Savart law and FEM. The performance of the forward solver is analysed and found to be enough for use in MREIT for resistivity image reconstructions and also experimental designs and validations. The forward solver may find other applications where one needs to compute voltage, current density and magnetic flux density distributions all within a volume conductor. PMID:12884929

  12. Obtaining DDF Curves of Extreme Rainfall Data Using Bivariate Copula and Frequency Analysis

    NASA Astrophysics Data System (ADS)

    Sadri, S.; Madsen, H.; Mikkelsen, P. S.; Burn, D. H.

    2009-05-01

    The traditional rainfall intensity-duration-frequency (IDF) curve is a reliable approach for representing the variation of rainfall intensity with duration for a given return period. In reality rainfall variables intensity, depth and duration are dependent and therefore a bivariate analysis using copulas can give a more accurate IDF curve. We study IDF curves using a copula in a bivariate frequency analysis of extreme rainfall. To be able to choose the most suitable copula among candidate copulas (i.e., Gumbel, Clayton, and Frank) we demonstrated IDF curves based on variation of depth with duration for a given return period and name them DDF (depth-duration-frequency) curves. The copula approach does not assume the rainfall variables are independent or jointly normally distributed. Rainfall series are extracted in three ways: (1) by maximum mean intensity; (2) by depth and duration of individual rainfall events; and (3) by storage volume and duration. In each case we used partial duration series (PDS) to extract extreme rainfall variables. The DDF curves derived from each method are presented and compared. This study examines extreme rainfall data from catchment Vedbæ k Renseanlæ g, situated near Copenhagen in Denmark. For rainfall extracted using method 2, the marginal distribution of depth was found to fit the Generalized Pareto distribution while duration was found to fit the Gamma distribution, using the method of L-moments. The volume was fit with a generalized Pareto distribution and the duration was fit with a Pearson type III distribution for rainfall extracted using method 3. The Clayton copula was found to be appropriate for bivariate analysis of rainfall depth and duration for both methods 2 and 3. DDF curves derived using the Clayton copula for depth and duration of individual rainfall events (method 2) are in agreement with empirically derived DDF curves obtained from maximum mean intensity (method 1) for a 10-year return period. For a 100-year return period the estimates differ by 2.5 cm for a 5 hr duration. This difference diminishes to almost zero for a 50 hr duration. If rainfall series are extracted by storage volume and duration (method 3), the difference between DDF curves derived from the Clayton copula and the empirical DDF curves are more appreciable and in general, DDF curves derived from method 3 show a smaller depth for the same duration for any selected return period. The differences between DDF curves illustrates that the method of extracting extreme rainfall as well as the frequency analysis approach have a considerable effect on the resulting DDF curves.

  13. Drainage-system development in consecutive melt seasons at a polythermal, Arctic glacier, evaluated by flow-recession analysis and linear-reservoir simulation

    NASA Astrophysics Data System (ADS)

    Hodgkins, Richard; Cooper, Richard; Tranter, Martyn; Wadham, Jemma

    2013-07-01

    The drainage systems of polythermal glaciers play an important role in high-latitude hydrology, and are determinants of ice flow rate. Flow-recession analysis and linear-reservoir simulation of runoff time series are here used to evaluate seasonal and inter-annual variability in the drainage system of the polythermal Finsterwalderbreen, Svalbard, in 1999 and 2000. Linear-flow recessions are pervasive, with mean coefficients of a fast reservoir varying from 16 (1999) to 41 h (2000), and mean coefficients of an intermittent, slow reservoir varying from 54 (1999) to 114 h (2000). Drainage-system efficiency is greater overall in the first of the two seasons, the simplest explanation of which is more rapid depletion of the snow cover. Reservoir coefficients generally decline during each season (at 0.22 h d-1 in 1999 and 0.52 h d-1 in 2000), denoting an increase in drainage efficiency. However, coefficients do not exhibit a consistent relationship with discharge. Finsterwalderbreen therefore appears to behave as an intermediate case between temperate glaciers and other polythermal glaciers with smaller proportions of temperate ice. Linear-reservoir runoff simulations exhibit limited sensitivity to a relatively wide range of reservoir coefficients, although the use of fixed coefficients in a spatially lumped model can generate significant subseasonal error. At Finsterwalderbreen, an ice-marginal channel with the characteristics of a fast reservoir, and a subglacial upwelling with the characteristics of a slow reservoir, both route meltwater to the terminus. This suggests that drainage-system components of significantly contrasting efficiencies can coexist spatially and temporally at polythermal glaciers.

  14. Drainage-system development in consecutive melt seasons at a polythermal, Arctic glacier, evaluated by flow-recession analysis and linear-reservoir simulation

    PubMed Central

    Hodgkins, Richard; Cooper, Richard; Tranter, Martyn; Wadham, Jemma

    2013-01-01

    [1] The drainage systems of polythermal glaciers play an important role in high-latitude hydrology, and are determinants of ice flow rate. Flow-recession analysis and linear-reservoir simulation of runoff time series are here used to evaluate seasonal and inter-annual variability in the drainage system of the polythermal Finsterwalderbreen, Svalbard, in 1999 and 2000. Linear-flow recessions are pervasive, with mean coefficients of a fast reservoir varying from 16 (1999) to 41 h (2000), and mean coefficients of an intermittent, slow reservoir varying from 54 (1999) to 114 h (2000). Drainage-system efficiency is greater overall in the first of the two seasons, the simplest explanation of which is more rapid depletion of the snow cover. Reservoir coefficients generally decline during each season (at 0.22 h d?1 in 1999 and 0.52 h d?1 in 2000), denoting an increase in drainage efficiency. However, coefficients do not exhibit a consistent relationship with discharge. Finsterwalderbreen therefore appears to behave as an intermediate case between temperate glaciers and other polythermal glaciers with smaller proportions of temperate ice. Linear-reservoir runoff simulations exhibit limited sensitivity to a relatively wide range of reservoir coefficients, although the use of fixed coefficients in a spatially lumped model can generate significant subseasonal error. At Finsterwalderbreen, an ice-marginal channel with the characteristics of a fast reservoir, and a subglacial upwelling with the characteristics of a slow reservoir, both route meltwater to the terminus. This suggests that drainage-system components of significantly contrasting efficiencies can coexist spatially and temporally at polythermal glaciers. PMID:25598557

  15. Simplified Arc-Flash Hazard Analysis Using Energy Boundary Curves

    Microsoft Academic Search

    Antony C. Parsons; W. Blane Leuschner; Kevin X. Jiang

    2008-01-01

    A simplified analysis technique that allows for the determination of required arc-flash personal protective equipment (PPE) based on IEEE Std. 1584-2002 and overcurrent protective device (OCPD) characteristics is presented. Unlike the simplified equations in IEEE 1584, this analysis technique can potentially be applied to any type of OCPD on any power system within the range of applicability of the IEEE

  16. Parent involvement and science achievement: A latent growth curve analysis

    NASA Astrophysics Data System (ADS)

    Johnson, Ursula Yvette

    This study examined science achievement growth across elementary and middle school and parent school involvement using the Early Childhood Longitudinal Study - Kindergarten Class of 1998--1999 (ECLS-K). The ECLS-K is a nationally representative kindergarten cohort of students from public and private schools who attended full-day or half-day kindergarten class in 1998--1999. The present study's sample (N = 8,070) was based on students that had a sampling weight available from the public-use data file. Students were assessed in science achievement at third, fifth, and eighth grades and parents of the students were surveyed at the same time points. Analyses using latent growth curve modeling with time invariant and varying covariates in an SEM framework revealed a positive relationship between science achievement and parent involvement at eighth grade. Furthermore, there were gender and racial/ethnic differences in parents' school involvement as a predictor of science achievement. Findings indicated that students with lower initial science achievement scores had a faster rate of growth across time. The achievement gap between low and high achievers in earth, space and life sciences lessened from elementary to middle school. Parents' involvement with school usually tapers off after elementary school, but due to parent school involvement being a significant predictor of eighth grade science achievement, later school involvement may need to be supported and better implemented in secondary schooling.

  17. Computational analysis of blood volume curves and risk of intradialytic morbid events in hemodialysis

    Microsoft Academic Search

    Joachim Beige; Jeremiah Sone; Arya M. Sharma; Martin Rudwaleit; Gerd Offermann; Armin Distler; Lothar Preuschof

    2000-01-01

    Computational analysis of blood volume curves and risk of intradialytic morbid events in hemodialysis.BackgroundBlood volume (BV) curves have been used to prevent intradialytic morbid events (IMEs) caused by hypotensive episodes in hemodialysis treatment. However, no standardized parameter is available to describe BV dynamics and to enable online interference with ultrafiltration rates in unselected patients. Moreover, only time-dependent BV reduction and

  18. Analysis, design and construction of curved composite girder bridges: State-of-the-art

    Microsoft Academic Search

    Weiwei Lin; Teruhiko Yoda

    2010-01-01

    The horizontally curved composite girder bridges have excellent properties, such as quick construction, good seismic performance,\\u000a saving construction formwork and convenience in spatial arrangement.etc, which have greatly promoted the application of such\\u000a bridges. The objective of this paper is to provide and summarize important references related to the analysis, design and\\u000a construction of curved composite girder bridges. Subjects discussed in

  19. Family size limitation: a method for demonstrating recessive inheritance

    Microsoft Academic Search

    J F Brookfield; R J Pollitt; I D Young

    1988-01-01

    Limitation of family size after the birth of a child with a serious disorder poses a problem in demonstrating autosomal recessive inheritance. In this paper methods are presented for distinguishing autosomal recessive inheritance given a 100% deterrent effect, and revealing a partial deterrent effect by analysis of sibship size and comparison with general population data. These methods are illustrated using

  20. Who Suffers during Recessions? NBER Working Paper No. 17951

    ERIC Educational Resources Information Center

    Hoynes, Hilary W.; Miller, Douglas L.; Schaller, Jessamyn

    2012-01-01

    In this paper we examine how business cycles affect labor market outcomes in the United States. We conduct a detailed analysis of how cycles affect outcomes differentially across persons of differing age, education, race, and gender, and we compare the cyclical sensitivity during the Great Recession to that in the early 1980s recession. We present…

  1. Rapid genotyping of beak and feather disease virus using high-resolution DNA melt curve analysis.

    PubMed

    Sarker, Subir; Ghorashi, Seyed A; Forwood, Jade K; Raidal, Shane R

    2014-11-01

    Beak and feather disease virus (BFDV) is a significant pathogen both for wild and captive psittacine birds globally. Genotypic differentiation of BFDV isolates is crucial to establish effective control strategies for the conservation of endangered species and epidemiological investigations of disease outbreaks. The technique developed in this study is a simple, rapid and inexpensive genotyping method for BFDV using PCR and subsequent high-resolution melt (HRM) curve analysis. This was achieved using PCR amplification of the conserved Rep gene in the presence of a fluorescent DNA intercalating dye (SYTO9). HRM curve analysis of the resultant amplicon could readily differentiate between reference strain (92-SR14) and 18 other BFDV isolates used in this study. Analysis of the nucleotide sequences of the amplicon from each isolate revealed that each melt curve profile was related to a unique DNA sequence. The potential of the PCR-HRM curve analysis to differentiate inter-host genetic variation among critically endangered orange-bellied parrots, lorikeets and cockatoos was also evaluated. Phylogenetic tree topology based on partial Rep gene sequences used in this study showed that BFDV Rep gene sequence patterns were correlated with the results of HRM curve analysis. The results presented in this study indicate that this technique could be used in both clinical research and differentiation of BFDV isolates in a fraction of time without further nucleotide sequencing and provides a novel approach for the genetic screening of BFDV in clinical virology laboratories. PMID:25102431

  2. Analysis of gas deliverability curves for predicting future well performance

    E-print Network

    Corbett, Thomas Gary

    1985-01-01

    for calculating flowing bottomhole were especially inadequate. A better approach to analyzing backpressure tests makes use of the real gas pseudo-pressure equation for pseudosteady-state flow. This equation incorporates a non-Darcy flow term, and correctly... ACKNOWLEDGEMENTS . TABLE OF CONTENTS LIST OF TABLES LIST OF FIGURES INTRODUCTION CONVENTIONAL ANALYSIS OF BACKPRESSURE TESTS REAL GAS PSEUDO-PRESSURE ANALYSIS RESULTS Effects of Real Gas Behavior and Non-Darcy Flow page V1 V 11 V 11 1 10 10 Shifting...

  3. Iceland Glacier Recession 1997 to 2000

    NSDL National Science Digital Library

    Lori Perkins

    2001-04-09

    This animation is a close up zoom into largest area of glacier recesion at the Breidamerkurjokull glacier in Iceland. The data from 1997 is taken from Landsat 5 and the 2000 data is from Landsat 7. The Breidamerkurjokull glacier in Iceland has been measured by Landsat to be receding since 1973. In 1997, Landsat 5 took several other images of the glacier. It was thought by some glacierologists that this particular glacier was receding quicker in the late 1990s than it did in the late 1980s or 1970s. After careful analysis Goddards Glacierologist, Dorothy Hall, concluded that the recession from 1997 to 2000 occurs at a similar rate to the recession between 1973 and 2000. It is extremely controversial whether or not this recession is caused by global warming.

  4. Analysis of agonist-agonist interactions: the crucial influence of curve shape.

    PubMed

    Scaramellini, C; Bennett, G; Leff, P

    1997-04-01

    The two-receptor:one-transducer model (Leff, 1987) is here extended to analyze interactions between agonists displaying E[A] curves of different shapes, by incorporating slope factors into the separate and common parts of the transduction pathway. Interactions were modelled as the effect of one agonist, at fixed concentration, on the curve to the other. A variety of patterns of position and slope changes are predicted. These do not depend on the shape of the control curve, rather, they depend on the slope factors in the separate and common pathways. The following specific predictions are made: (1) when the common pathway is steep, curves undergo potentiation and flattening; (2) when the common pathway is flat, curves undergo right-shift and steepening; (3) when the common pathway is hyperbolic, curves undergo right-shift, with no slope change; (4) when the slope depends on the separate pathways, curves only undergo right-shift with no change in slope. The model provides a sound basis for classifying agonist interactions and for detecting additional, synergistic or antagonistic properties. This analysis indicates that methods based on dose-additivity or independence are less reliable for these purposes. The model provides a practical test, based on slope changes, to detect and quantify additional properties. PMID:9253753

  5. A new methodology for free wake analysis using curved vortex elements

    NASA Technical Reports Server (NTRS)

    Bliss, Donald B.; Teske, Milton E.; Quackenbush, Todd R.

    1987-01-01

    A method using curved vortex elements was developed for helicopter rotor free wake calculations. The Basic Curve Vortex Element (BCVE) is derived from the approximate Biot-Savart integration for a parabolic arc filament. When used in conjunction with a scheme to fit the elements along a vortex filament contour, this method has a significant advantage in overall accuracy and efficiency when compared to the traditional straight-line element approach. A theoretical and numerical analysis shows that free wake flows involving close interactions between filaments should utilize curved vortex elements in order to guarantee a consistent level of accuracy. The curved element method was implemented into a forward flight free wake analysis, featuring an adaptive far wake model that utilizes free wake information to extend the vortex filaments beyond the free wake regions. The curved vortex element free wake, coupled with this far wake model, exhibited rapid convergence, even in regions where the free wake and far wake turns are interlaced. Sample calculations are presented for tip vortex motion at various advance ratios for single and multiple blade rotors. Cross-flow plots reveal that the overall downstream wake flow resembles a trailing vortex pair. A preliminary assessment shows that the rotor downwash field is insensitive to element size, even for relatively large curved elements.

  6. AtomicJ: An open source software for analysis of force curves

    NASA Astrophysics Data System (ADS)

    Hermanowicz, Pawe?; Sarna, Micha?; Burda, Kvetoslava; Gabry?, Halina

    2014-06-01

    We present an open source Java application for analysis of force curves and images recorded with the Atomic Force Microscope. AtomicJ supports a wide range of contact mechanics models and implements procedures that reduce the influence of deviations from the contact model. It generates maps of mechanical properties, including maps of Young's modulus, adhesion force, and sample height. It can also calculate stacks, which reveal how sample's response to deformation changes with indentation depth. AtomicJ analyzes force curves concurrently on multiple threads, which allows for high speed of analysis. It runs on all popular operating systems, including Windows, Linux, and Macintosh.

  7. AtomicJ: An open source software for analysis of force curves

    SciTech Connect

    Hermanowicz, Pawe?, E-mail: pawel.hermanowicz@uj.edu.pl; Gabry?, Halina [Department of Plant Biotechnology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Gronostajowa 7, 30–387 Kraków (Poland); Sarna, Micha?; Burda, Kvetoslava [Department of Medical Physics and Biophysics, Faculty of Physics and Applied Computer Science, AGH University of Science and Technology, al. Mickiewicza 30, 30-059 Kraków (Poland)

    2014-06-15

    We present an open source Java application for analysis of force curves and images recorded with the Atomic Force Microscope. AtomicJ supports a wide range of contact mechanics models and implements procedures that reduce the influence of deviations from the contact model. It generates maps of mechanical properties, including maps of Young's modulus, adhesion force, and sample height. It can also calculate stacks, which reveal how sample's response to deformation changes with indentation depth. AtomicJ analyzes force curves concurrently on multiple threads, which allows for high speed of analysis. It runs on all popular operating systems, including Windows, Linux, and Macintosh.

  8. Genome-wide analysis of defense-responsive genes in bacterial blight resistance of rice mediated by the recessive R gene xa13

    Microsoft Academic Search

    Z. Chu; Y. Ouyang; J. Zhang; H. Yang; S. Wang

    2004-01-01

    Defense responses triggered by dominant and recessive disease resistance ( R) genes are presumed to be regulated by different molecular mechanisms. In order to characterize the genes activated in defense responses against bacterial blight mediated by the recessive R gene xa13, two pathogen-induced subtraction cDNA libraries were constructed using the resistant rice line IRBB13—which carries xa13 —and its susceptible, near-isogenic,

  9. TTF HOM Data Analysis with Curve Fitting Method

    SciTech Connect

    Pei, S.; Adolphsen, C.; Li, Z.; Bane, K.; Smith, J.; /SLAC

    2009-07-14

    To investigate the possibility of using HOM signals induced in SC cavities as beam and cavity diagnostics, narrow band (20 MHz) data was recorded around the strong TE111-6(6{pi}/9-like) dipole modes (1.7 GHz) in the 40 L-band (1.3 GHz) cavities at the DESY TTF facility. The analyses of these data have so far focused on using a Singular Value Decomposition (SVD) technique to correlate the signals with each other and data from conventional BPMs to show the dipole signals provide an alternate means of measuring the beam trajectory. However, these analyses do not extract the modal information (i.e., frequencies and Q's of the nearly degenerate horizontal and vertical modes). In this paper, we described a method to fit the signal frequency spectrum to obtain this information, and then use the resulting mode amplitudes and phases together with conventional BPM data to determine the mode polarizations and relative centers and tilts. Compared with the SVD analysis, this method is more physical, and can also be used to obtain the beam position and trajectory angle.

  10. Testing and analysis of flat and curved panels with multiple cracks

    NASA Technical Reports Server (NTRS)

    Broek, David; Jeong, David Y.; Thomson, Douglas

    1994-01-01

    An experimental and analytical investigation of multiple cracking in various types of test specimens is described in this paper. The testing phase is comprised of a flat unstiffened panel series and curved stiffened and unstiffened panel series. The test specimens contained various configurations for initial damage. Static loading was applied to these specimens until ultimate failure, while loads and crack propagation were recorded. This data provides the basis for developing and validating methodologies for predicting linkup of multiple cracks, progression to failure, and overall residual strength. The results from twelve flat coupon and ten full scale curved panel tests are presented. In addition, an engineering analysis procedure was developed to predict multiple crack linkup. Reasonable agreement was found between predictions and actual test results for linkup and residual strength for both flat and curved panels. The results indicate that an engineering analysis approach has the potential to quantitatively assess the effect of multiple cracks in the arrest capability of an aircraft fuselage structure.

  11. CT of the pericardial recesses

    SciTech Connect

    Levy-Ravetch, M.; Auh, Y.H.; Rubenstein, W.A.; Whalen, J.P.; Kazam, E.

    1985-04-01

    Within the pericardial cavity there are several recesses where fluid can collect in close contiguity to the major bronchi and lymph nodes. These include the transverse sinus, behind the ascending aorta and pulmonary trunk; the oblique sinus, behind the left atrium; and the left pulmonic recess, between the left pulmonary artery and the left superior pulmonary vein. There are also smaller pericardial recesses between the superior and inferior pulmonary veins, posterolateral to the superior vena cava, and between the inferior vena cava and coronary sinus. An understanding of sectional anatomy is valuable for differentiation of fluid within these recesses from mediastinal masses or enlarged lymph nodes on computed tomographic scans.

  12. Flood Envelope Curves for the Setouchi Region Derived by Spatial Distribution Analysis of Radar Rainfall

    NASA Astrophysics Data System (ADS)

    Chikamori, Hidetaka; Nagai, Akihiro

    This paper presents the estimation procedure of a flood envelope curve originally developed by Kadoya and Nagai (1979) on the basis of depth-area-duration (DAD) analysis of radar precipitation data in order to examine the availability of spatial distribution data of precipitation for statistical flood peak analysis. The estimated flood envelope curves by applying the presented procedure to the Yoshii River Basin located in Okayama Prefecture of the western Japan well enveloped the flood peaks observed in the Hiroshima and Okayama Prefectures; the curves tended, however, to overestimate flood peaks for small catchments. It was explained by the fact that very limited areas are with regionally maximum areal rainfall arising maximum flood peak discharge and the other areas are with smaller areal rainfall than maximum in the objective region. Flood envelope curve equation considering spatial probability of regionally maximum areal rainfall was presented and applied to the Yoshii River Basin to show the effect of adjusting the spatial probability for mitigating overestimation of maximum flood peaks for small basin. This result shows probabilistic aspects of flood envelope curves deterministically estimated from hydrological records, which should be considered when determining design flood discharge for dam planning.

  13. Efficient computer program for decline curve analysis of oil and gas wells

    Microsoft Academic Search

    1982-01-01

    This work explains the development and the applications of a simple, accurate, and efficient computer program for decline curve analysis of both oil and gas wells. By utilizing root extraction technique in numeric methods, the decline exponent n of a given oil\\/gas property with production rate-time data can be computed directly and the initial decline rate Di then can be

  14. A Latent Growth Curve Analysis of Reading Achievement for an At-Risk Population

    ERIC Educational Resources Information Center

    Beecher, Constance C.

    2011-01-01

    The development of reading skills from age seven until age 19 was investigated for children who were referred for special education preschool intervention using latent growth curve analysis (n=206). Approximately one-third of the study sample did not require special education services after preschool, providing a natural comparison group. Reading…

  15. Linearized limb-darkening coefficients for use in analysis of eclipsing binary light curves

    Microsoft Academic Search

    Hamid M. Al-Naimiy

    1978-01-01

    Linear limb-darkening coefficientsu required in the analysis of eclipsing binary curves, are tabulated for a wide range of effective temperature (50 000° to 4000°), wavelength ? (0.2 µ=?=2.2 µ), and gravitiesg (2.0=logg=5.0). The computation is based on the comprehensive range of model atmospheres of Carbon and Gingerich (1969).

  16. High resolution melting curve analysis of DNA samples isolated by different DNA extraction methods

    Microsoft Academic Search

    Gracia M. Martín-Núñez; Juan M. Gómez-Zumaquero; Federico Soriguer; Sonsoles Morcillo

    BackgroundHigh resolution melting is a post-PCR-based method for detecting DNA sequence variation by measuring changes in the melting of a DNA duplex. Melting of double-stranded DNA molecules is influenced by several factors. We evaluated the influence of the DNA isolation method in the melting curve analysis to detect genetic variations.

  17. Beamlet Pyramids: A New Form of Multiresolution Analysis, suited for Extracting Lines, Curves, and Objects

    E-print Network

    Huo, Xiaoming

    Beamlet Pyramids: A New Form of Multiresolution Analysis, suited for Extracting Lines, Curves describe a multiscale pyramid of line segments and develop algorithms which exploit that pyramid to recover. The resulting information is stored in an beamlet pyramid. One can use this to rapidly calculate integrals of f

  18. A functional analysis of electrical load curve modelling for some households specific electricity end-uses

    E-print Network

    Paris-Sud XI, Université de

    A functional analysis of electrical load curve modelling for some households specific electricity a series of deep technical and behavioural breaks. Among them are : the integration of new electrical domestic end-uses, the development of plug-in hybrid and electric vehicles, the increase of heat pumps

  19. Moving Out the Learning Curve: An Analysis of Hard Clam, Mercenaria mercenaria,

    E-print Network

    Moving Out the Learning Curve: An Analysis of Hard Clam, Mercenaria mercenaria, Nursery Operations clam mariculture in South Carolina. The cooperative agreement requires Trident Seafanns to provide analyses ofthe nursery phase ofa commercial- scale hard clam farming operation are pre- sented

  20. Protections against Differential Analysis for Elliptic Curve Cryptography — An Algebraic Approach —

    Microsoft Academic Search

    Marc Joye; Christophe Tymen

    \\u000a We propose several new methods to protect the scalar multiplication on an elliptic curve against Differential Analysis. The\\u000a basic idea consists in transforming the curve through various random morphisms to provide a non-deterministic execution of\\u000a the algorithm.\\u000a \\u000a \\u000a The solutions we suggest complement and improve the state-of-the-art, but also provide a practical toolbox of efficient countermeasures.\\u000a These should suit most of

  1. Copper nanoparticle analysis for peristaltic flow in a curved channel with heat transfer characteristics

    NASA Astrophysics Data System (ADS)

    Sher Akbar, Noreen; Maraj, E. N.; Nadeem, S.

    2014-07-01

    In this paper, the mathematical investigation is carried out to discuss the metallic nanoparticle analysis for peristaltic flow in a curved channel. The study of copper nanoparticles in the peristaltic literature with water as base fluid is not explored yet for a curved channel. The equations for the Cu-water nanofluid are formulated for the first time in the literature and simplified under the long-wavelength and low-Reynolds-number assumptions. Exact solutions of nonlinear coupled differential equations are evaluated. The results are discussed graphically for different values of important parameters.

  2. Computational tools for probing interaction effects in multiple linear regression, multilevel modeling, and latent curve analysis

    E-print Network

    Preacher, K. J.; Curran, Patrick J.; Bauer, D. J.

    2007-04-09

    ), the random effects multilevel/hierarchical linear model (HLM) (Bauer & Curran, 2005; Curran, Bauer, & Willoughby, 2006), and the structural equation-based latent curve analysis (LCA) model (Curran, Bauer, & Willoughby, 2004). In these articles we also..., J., Cohen, P., West, S. G., & Aiken, L. S. (2003). Applied multiple regressionl correlation analysis for the behavioral sciences (3rd ed.). Hillsdale, NJ: Erlbaum. Curran, P. J., Bauer, D. J., & Willoughby, M. T. (2004). Testing main effects...

  3. Colorado's Economic Recovery since the Great Recession Professor Martin Shields

    E-print Network

    . This report has two main sections. First, we look at statewide and comparative Recession in December 2007. We also look at the implications that a slow recovery our analysis, we provide key definitions and describe data sources at the end

  4. Fort Play Children Recreate Recess

    ERIC Educational Resources Information Center

    Powell, Mark

    2007-01-01

    Recess beckons well before it actually arrives. Its allure can be heard in children's lunchtime conversations as they discuss imaginary roles, plans, alliances and teams, with an obvious appetite for play and its unbounded possibility. For some children, recess provides the most important reasons to come to school. In team sports, games of chase…

  5. Autosomal recessive congenital ichthyosis.

    PubMed

    Rodríguez-Pazos, L; Ginarte, M; Vega, A; Toribio, J

    2013-05-01

    The term autosomal recessive congenital ichthyosis (ARCI) refers to a group of rare disorders of keratinization classified as nonsyndromic forms of ichthyosis. This group was traditionally divided into lamellar ichthyosis (LI) and congenital ichthyosiform erythroderma (CIE) but today it also includes harlequin ichthyosis, self-healing collodion baby, acral self-healing collodion baby, and bathing suit ichthyosis. The combined prevalence of LI and CIE has been estimated at 1 case per 138 000 to 300 000 population. In some countries or regions, such as Norway and the coast of Galicia, the prevalence may be higher due to founder effects. ARCI is genetically highly heterogeneous and has been associated with 6 genes to date: TGM1, ALOXE3, ALOX12B, NIPAL4, CYP4F22, and ABCA12. In this article, we review the current knowledge on ARCI, with a focus on clinical, histological, ultrastructural, genetic, molecular, and treatment-related aspects. PMID:23562412

  6. A computational model-based validation of Guyton's analysis of cardiac output and venous return curves

    NASA Technical Reports Server (NTRS)

    Mukkamala, R.; Cohen, R. J.; Mark, R. G.

    2002-01-01

    Guyton developed a popular approach for understanding the factors responsible for cardiac output (CO) regulation in which 1) the heart-lung unit and systemic circulation are independently characterized via CO and venous return (VR) curves, and 2) average CO and right atrial pressure (RAP) of the intact circulation are predicted by graphically intersecting the curves. However, this approach is virtually impossible to verify experimentally. We theoretically evaluated the approach with respect to a nonlinear, computational model of the pulsatile heart and circulation. We developed two sets of open circulation models to generate CO and VR curves, differing by the manner in which average RAP was varied. One set applied constant RAPs, while the other set applied pulsatile RAPs. Accurate prediction of intact, average CO and RAP was achieved only by intersecting the CO and VR curves generated with pulsatile RAPs because of the pulsatility and nonlinearity (e.g., systemic venous collapse) of the intact model. The CO and VR curves generated with pulsatile RAPs were also practically independent. This theoretical study therefore supports the validity of Guyton's graphical analysis.

  7. Learning Factors Transfer Analysis: Using Learning Curve Analysis to Automatically Generate Domain Models

    ERIC Educational Resources Information Center

    Pavlik, Philip I. Jr.; Cen, Hao; Koedinger, Kenneth R.

    2009-01-01

    This paper describes a novel method to create a quantitative model of an educational content domain of related practice item-types using learning curves. By using a pairwise test to search for the relationships between learning curves for these item-types, we show how the test results in a set of pairwise transfer relationships that can be…

  8. ATWS Analysis with an Advanced Boiling Curve Approach within COBRA 3-CP

    SciTech Connect

    Gensler, A.; Knoll, A.; Kuehnel, K. [AREVA, AREVA NP GmbH, Freyeslebenstr. 1, D-91058 Erlangen (Germany)

    2007-07-01

    In 2005 the German Reactor Safety Commission issued specific requirements on core coolability demonstration for PWR ATWS (anticipated transients without scram). Thereupon AREVA NP performed detailed analyses for all German PWRs. For a German KONVOI plant the results of an ATWS licensing analysis are presented. The plant dynamic behavior is calculated with NLOOP, while the hot channel analysis is performed with the thermal hydraulic computer code COBRA 3-CP. The application of the fuel rod model included in COBRA 3-CP is essential for this type of analysis. Since DNB (departure from nucleate boiling) occurs, the advanced post DNB model (advanced boiling curve approach) of COBRA 3-CP is used. The results are compared with those gained with the standard BEEST model. The analyzed ATWS case is the emergency power case 'loss of main heat sink with station service power supply unavailable'. Due to the decreasing coolant flow rate during the transient the core attains film boiling conditions. The results of the hot channel analysis strongly depend on the performance of the boiling curve model. The BEEST model is based on pool boiling conditions whereas typical PWR conditions - even in most transients - are characterized by forced flow for which the advanced boiling curve approach is particularly suitable. Compared with the BEEST model the advanced boiling curve approach in COBRA 3-CP yields earlier rewetting, i.e. a shorter period in film boiling. Consequently, the fuel rod cladding temperatures, that increase significantly due to film boiling, drop back earlier and the high temperature oxidation is significantly diminished. The Baker-Just-Correlation was used to calculate the value of equivalent cladding reacted (ECR), i.e. the reduction of cladding thickness due to corrosion throughout the transient. Based on the BEEST model the ECR value amounts to 0.4% whereas the advanced boiling curve only leads to an ECR value of 0.2%. Both values provide large margins to the 17% ECR limit. The maximum cladding temperature calculated with both models is almost identical. It results in approximately 830 deg. C, i.e. far below the embrittlement temperature (stipulated at 1200 deg. C). Core coolability was demonstrated with both models, with the BEEST model and with the advanced boiling curve approach. However, the advanced boiling curve approach results in more realistic values and reveals that a much higher safety margin exists. This advantage can be applied to all types of transient hot channel analyses which have to treat film boiling phases. (authors)

  9. Differentiating between monozygotic twins through DNA methylation-specific high-resolution melt curve analysis.

    PubMed

    Stewart, Leander; Evans, Neil; Bexon, Kimberley J; van der Meer, Dieudonne J; Williams, Graham A

    2015-05-01

    Although short tandem repeat profiling is extremely powerful in identifying individuals from crime scene stains, it is unable to differentiate between monozygotic (MZ) twins. Efforts to address this include mutation analysis through whole genome sequencing and through DNA methylation studies. Methylation of DNA is affected by environmental factors; thus, as MZ twins age, their DNA methylation patterns change. This can be characterized by bisulfite treatment followed by pyrosequencing. However, this can be time-consuming and expensive; thus, it is unlikely to be widely used by investigators. If the sequences are different, then in theory the melting temperature should be different. Thus, the aim of this study was to assess whether high-resolution melt curve analysis can be used to differentiate between MZ twins. Five sets of MZ twins provided buccal swabs that underwent extraction, quantification, bisulfite treatment, polymerase chain reaction amplification and high-resolution melting curve analysis targeting two markers, Alu-E2F3 and Alu-SP. Significant differences were observed between all MZ twins targeting Alu-E2F3 and in four of five MZ twins targeting Alu-SP (P<0.05). Thus, it has been demonstrated that bisulfite treatment followed by high-resolution melting curve analysis could be used to differentiate between MZ twins. PMID:25677265

  10. Eprobe mediated real-time PCR monitoring and melting curve analysis.

    PubMed

    Hanami, Takeshi; Delobel, Diane; Kanamori, Hajime; Tanaka, Yuki; Kimura, Yasumasa; Nakasone, Ayako; Soma, Takahiro; Hayashizaki, Yoshihide; Usui, Kengo; Harbers, Matthias

    2013-01-01

    Real-time monitoring of PCR is one of the most important methods for DNA and RNA detection widely used in research and medical diagnostics. Here we describe a new approach for combined real-time PCR monitoring and melting curve analysis using a 3' end-blocked Exciton-Controlled Hybridization-sensitive fluorescent Oligonucleotide (ECHO) called Eprobe. Eprobes contain two dye moieties attached to the same nucleotide and their fluorescent signal is strongly suppressed as single-stranded oligonucleotides by an excitonic interaction between the dyes. Upon hybridization to a complementary DNA strand, the dyes are separated and intercalate into the double-strand leading to strong fluorescence signals. Intercalation of dyes can further stabilize the DNA/DNA hybrid and increase the melting temperature compared to standard DNA oligonucleotides. Eprobes allow for specific real-time monitoring of amplification reactions by hybridizing to the amplicon in a sequence-dependent manner. Similarly, Eprobes allow for analysis of reaction products by melting curve analysis. The function of different Eprobes was studied using the L858R mutation in the human epidermal growth factor receptor (EGFR) gene, and multiplex detection was demonstrated for the human EGFR and KRAS genes using Eprobes with two different dyes. Combining amplification and melting curve analysis in a single-tube reaction provides powerful means for new mutation detection assays. Functioning as "sequence-specific dyes", Eprobes hold great promises for future applications not only in PCR but also as hybridization probes in other applications. PMID:23951046

  11. Eprobe Mediated Real-Time PCR Monitoring and Melting Curve Analysis

    PubMed Central

    Kanamori, Hajime; Tanaka, Yuki; Kimura, Yasumasa; Nakasone, Ayako; Soma, Takahiro; Hayashizaki, Yoshihide; Usui, Kengo; Harbers, Matthias

    2013-01-01

    Real-time monitoring of PCR is one of the most important methods for DNA and RNA detection widely used in research and medical diagnostics. Here we describe a new approach for combined real-time PCR monitoring and melting curve analysis using a 3? end-blocked Exciton-Controlled Hybridization-sensitive fluorescent Oligonucleotide (ECHO) called Eprobe. Eprobes contain two dye moieties attached to the same nucleotide and their fluorescent signal is strongly suppressed as single-stranded oligonucleotides by an excitonic interaction between the dyes. Upon hybridization to a complementary DNA strand, the dyes are separated and intercalate into the double-strand leading to strong fluorescence signals. Intercalation of dyes can further stabilize the DNA/DNA hybrid and increase the melting temperature compared to standard DNA oligonucleotides. Eprobes allow for specific real-time monitoring of amplification reactions by hybridizing to the amplicon in a sequence-dependent manner. Similarly, Eprobes allow for analysis of reaction products by melting curve analysis. The function of different Eprobes was studied using the L858R mutation in the human epidermal growth factor receptor (EGFR) gene, and multiplex detection was demonstrated for the human EGFR and KRAS genes using Eprobes with two different dyes. Combining amplification and melting curve analysis in a single-tube reaction provides powerful means for new mutation detection assays. Functioning as “sequence-specific dyes”, Eprobes hold great promises for future applications not only in PCR but also as hybridization probes in other applications. PMID:23951046

  12. GCAFIT—A new tool for glow curve analysis in thermoluminescence nanodosimetry

    NASA Astrophysics Data System (ADS)

    Abd El-Hafez, A. I.; Yasin, M. N.; Sadek, A. M.

    2011-05-01

    Glow curve analysis is widely used for dosimetric studies and applications. Therefore, a new computer program, GCAFIT, for deconvoluting first-order kinetics thermoluminescence (TL) glow curves and evaluating the activation energy for each glow peak in the glow curve has been developed using the MATLAB technical computing language. A non-linear function describing a single glow peak is fitted to experimental points using the Levenberg-Marquardt least-square method. The developed GCAFIT software was used to analyze the glow curves of TLD-100, TLD-600, and TLD-700 nanodosimeters. The activation energy E obtained by the developed GCAFIT software was compared with that obtained by the peak shape methods of Grossweiner, Lushchik, and Halperin-Braner. The frequency factor S for each glow peak was also calculated. The standard deviations are discussed in each case and compared with those of other investigators. The results show that GCAFIT is capable of accurately analyzing first-order TL glow curves. Unlike other software programs, the developed GCAFIT software does not require activation energy as an input datum; in contrast, activation energy for each glow peak is given in the output data. The resolution of the experimental glow curve influences the results obtained by the GCAFIT software; as the resolution increases, the results obtained by the GCAFIT software become more accurate. The values of activation energy obtained by the developed GCAFIT software a in good agreement with those obtained by the peak shape methods. The agreement with the Halperin-Braner and Lushchik methods is better than with that of Grossweiner. High E and S values for peak 5 were observed; we believe that these values are not real because peak 5 may in fact consist of two or three unresolved peaks. We therefore treated E and S for peak 5 as an effective activation energy, Eeff, and an effective frequency factor, Seff. The temperature value for peak 5 was also treated as an effective quantity, Tm eff.

  13. Characterization of the mutation causative for autosomal recessive hereditary nephropathy in the english cocker spaniel and analysis of gene expression in multiple models of hereditary nephropathy

    E-print Network

    Davidson, Ashley Greene

    2009-05-15

    syndrome (AS), a group of heterogeneous, hereditary renal diseases, is one example of such a human disease. The disease is transmitted in three fashions: X-linked, autosomal recessive, and autosomal dominant. AS is caused by mutations in COL4?3, COL4?4...

  14. Useful concepts for decline-curve forecasting, reserve estimation, and analysis

    SciTech Connect

    Fetkovich, M.J.; Fetkovich, E.J.; Fetkovich, M.D. [Phillips Petroleum Co., Bartlesville, OK (United States)

    1996-02-01

    Decline-curve analysis, based on the Arps equations, has always been considered to be purely empirical with no basis on physical laws governing the flow of oil and gas through the formation. The purpose of this paper is to give engineers responsible for making forecasts and determining reserves for numerous operated or nonoperated wells some guidelines and fundamental concepts to allow them to make these forecasts and determinations more quickly and accurately.

  15. Thermo-XRD-analysis of montmorillonite treated with protonated Congo-red. Curve fitting

    Microsoft Academic Search

    Z. Yermiyahu; I. Lapides; S. Yariv

    2005-01-01

    The adsorption of protonated Congo red (CR) by montmorillonite was investigated by thermo-XRD-analysis. Montmorillonite was loaded at pH 1 with increasing amounts of CR up to 75 mmol per 100 g clay. Diffractograms of samples treated at 420 °C showed broad peaks and were curve-fitted to determine the different basal spacings, which composed the XRD peaks. The broad peak of

  16. Potential use of multivariate curve resolution for the analysis of mass spectrometry images.

    PubMed

    Jaumot, Joaquim; Tauler, Romà

    2015-02-01

    In this work the application of multivariate curve resolution is proposed for the analysis of Mass Spectrometry Imaging (MSI) data. Recently, developments in the ionization of samples have dramatically expanded the number of applications of MSI due to the possibility of collecting the mass spectrum for each pixel of a considered surface in a reasonable time. Using this method, both spatial distribution and spectral information of analyzed samples can be obtained. However, there are major drawbacks inherent to MSI related to the high complexity of the data obtained from real samples and to the extremely huge size of the datasets generated by this technique. Therefore, the potential of chemometrical tools in different steps of the analysis process is unquestionable, from data compression to data resolution of the different components present at each pixel of the image. In this work, this data analysis is carried out by means of the multivariate curve resolution method. The benefits of the application of this method are shown for two examples consisting of a MS image of two platted microbes and a MS image of a mouse lung section. The results show that multivariate curve resolution allows us to obtain distribution maps of different components and their identification from resolved high-resolution mass spectra. PMID:25460200

  17. Principal response curves technique for the analysis of multivariate biomonitoring time series.

    PubMed

    van den Brink, Paul J; den Besten, Piet J; bij de Vaate, Abraham; ter Braak, Cajo J F

    2009-05-01

    Although chemical and biological monitoring is often used to evaluate the quality of surface waters for regulatory purposes and/or to evaluate environmental status and trends, the resulting biological and chemical data sets are large and difficult to evaluate. Multivariate techniques have long been used to analyse complex data sets. This paper discusses the methods currently in use and introduces the principal response curves method, which overcomes the problem of cluttered graphical results representation that is a great drawback of most conventional methods. To illustrate this, two example data sets are analysed using two ordination techniques, principal component analysis and principal response curves. Whereas PCA results in a difficult-to-interpret diagram, principal response curves related methods are able to show changes in community composition in a diagram that is easy to read. The principal response curves method is used to show trends over time with an internal reference (overall mean or reference year) or external reference (e.g. preferred water quality or reference site). Advantages and disadvantages of both methods are discussed and illustrated. PMID:18484186

  18. Analysis of free energy versus temperature curves in protein folding and macromolecular interactions.

    PubMed

    LiCata, Vince J; Liu, Chin-Chi

    2011-01-01

    Plots of free energy versus temperature are commonly called stability curves or Gibbs-Helmholtz curves, and they have proven to be extremely useful in protein folding and ligand-binding studies. Curvature in a Gibbs-Helmholtz or stability plot is indicative of a heat capacity change, and some of their primary uses in biochemistry over the past few decades have included determining ?Cp values and comparing ?Cp values between two related processes. This chapter describes basic approaches for analyzing curved Gibbs-Helmholtz plots, along with two specific extensions of standard Gibbs-Helmholtz plot analysis: (1) translating ?G of folding versus temperature into ?H and ?S versus temperature for comparing mesophilic-thermophilic protein pairs, and (2) fitting Gibbs-Helmholtz plots to determine if ?Cp changes with temperature or not. Neither of these extensions is new, but they are infrequently used, and their use is particularly germane to certain molecular interpretations of thermodynamic information from ?G versus temperature curves. It is shown that translating ?G of folding into ?H and ?S of folding versus temperature for a mesophilic-thermophilic protein pair can immediately influence possible structural hypotheses for thermal stabilization of thermophilic proteins. It is also shown that very small temperature-dependent heat capacity changes (??Cp values) can be obtained from extended fits to ?G versus temperature plots, and that these very small ??Cp values can have serious consequences for any attempt to correlate ?Cp with ?ASA for some reactions. PMID:21195230

  19. A deformation analysis of flat flexible gear and its equation of original curved surfaces

    NASA Technical Reports Server (NTRS)

    Yunwen, S.

    1985-01-01

    The equation of the original curved surface of end harmonic gearing is determined by displacement analysis of flat flexible gear. The displacement analysis is also used to calculate the strength and rigidity of the gear. The latter is regarded as a circular plate with two concentrated loads, since its torsional rigidity is much larger than its bending rigidity. Small-deflection theory of thin plates is used to solve for the displacement of any point in the middle plane of the gear. New expressions are given for radial and tangential displacements of the middle plane under asymmetrical loading. A digital computer is used to obtain numerical values for the displacements.

  20. Modeling the Newtonian Dynamics for Rotation Curve Analysis of Thin-Disk Galaxies

    E-print Network

    James Q. Feng; C. F. Gallo

    2011-08-11

    We present an efficient, robust computational method for modeling the Newtonian dynamics for rotation curve analysis of thin-disk galaxies. For a disk galaxy with a typical flat rotation curve, our modeling results show that the surface mass density monotonically decreases from the galactic center toward periphery, according to Newtonian dynamics. In a large portion of the galaxy, the surface mass density follows an approximately exponential law of decay with respect to the galactic radial coordinate. Yet the radial scale length for the surface mass density seems to be generally larger than that of the measured brightness distribution, suggesting an increasing mass-to-light ratio with the radial distance in a disk galaxy. In a nondimensionalized form, our mathematical system contains a dimensionless parameter which we call the "galactic rotation number" that represents the gross ratio of centrifugal force and gravitational force. The value of this galactic rotation number is determined as part of the numerical solution. Through a systematic computational analysis, we have illustrated that this galactic rotation number remains within $\\pm 10%$ of 1.70 for a wide variety of rotation curves. This implies that the total mass in a disk galaxy is proportional to $V_0^2\\,R_g$, with $V_0$ denoting the characteristic rotation velocity and $R_g$ the radius of the galactic disk. The predicted total galactic mass of the Milky Way is in good agreement with the star-count data.

  1. Prediction of Cooling Curves for Squeeze Cast Al/SiCp Composites Using Finite Element Analysis

    NASA Astrophysics Data System (ADS)

    Gurusamy, P.; Balasivanandha Prabu, S.; Paskaramoorthy, R.

    2015-04-01

    This paper reports the experimental and finite element analyses of the solidification behavior of Al/SiCp composites, fabricated by the squeeze casting technique. Experiments were carried out by varying the melt temperatures for cylindrical-shaped composite castings. The composite samples were produced at the following constant temperatures: melt—1023 K, 1073 K, 1123 K, and 1173 K (750 °C, 800 °C, 850 °C, and 900 °C); and die—673 K (400 °C). The pressure applied throughout the experiment is 100 MPa. The melt temperature shows significant influence on the solidification behavior of the metal matrix composite. It was observed that the solidification time was 40 seconds when the melt temperature was 1023 K (750 °C) but it increased to 51 seconds when the melt temperature was at 1173 K (900 °C). The results also showed that the cooling rate decreased on increasing the melt temperature. Cooling curves for our system, squeeze cast composites, were predicted using the finite element software ANSYS. K-type thermocouples were interfaced to the die and the microcomputer from which the experimental cooling curves were constructed. The experimental and predicted cooling curves were then compared. While both show similar trends, the finite element analysis consistently under-predicts the temperature. In addition, finite element stress analysis reveals that both radial and tangential thermal stresses increase with the melt temperature.

  2. An elastic-plastic finite-element analysis of the J-resistance curve using a CTOD criterion

    NASA Technical Reports Server (NTRS)

    Newman, J. C., Jr.; Booth, B. C.; Shivakumar, K. N.

    1988-01-01

    The fracture process in compact and bend specimens was simulated using a two-dimensional finite-element analysis of the J-resistance (J-R) curve and a CTOD criterion. The J-R curves were calculated from the numerical results for each specimen type using several different methods. In general, the J-R curves obtained for the bend specimens were found to be higher than those for the compact specimens, especially beyond maximum load. However, below the maximum load, the modified deformation theory of plasticity and the contour-integral J(r) method resulted in very similar J-R curves for both specimen types.

  3. X-ray rocking curve analysis of strained heterointerfaces and quantum wells

    SciTech Connect

    Wie, C.R. [State Univ. of New York, Buffalo, NY (United States)

    1995-12-31

    A detailed discussion is given for the x-ray rocking curve analysis of semiconductor heterointerfaces and strained quantum wells using x-ray interferometry. It is shown that for a single beteroepitaxial layer sample and a multiple quantum well sample, the heterointerface where the composition changes in both anion and cation sublattices can be studied with a half monolayer sensitivity by analyzing the x-ray rocking curve profile. Such sample systems include GaInAs/InP, InGaSb, GaInP/GaAs, ZnSe/GaAs, etc. A simple kinematical diffraction principle involved in the x-ray analysis is explained. Namely, the relative phase difference between the reflection amplitudes of any two layers depends on the total sum of strain (or mismatch)-thickness products over the intervening layers and interfaces. The x-ray interferometry is also effective in measuring the strain-thickness product of strained quantum wells. Experimental data and analysis results are presented for a series of functional device structures having a strained quantum well. For a more complicated sample structure which involves both a (strained) quantum-effect layer and gained interfaces, it is shown that the x-ray interferometry is only capable of providing the total strain-thickness product over the quantum layer and the surrounding interfaces, but no detailed information about the interface grading can be gained from the rocking curve analysis alone if only one isolated sample is measured. An experimental data of such a sample, 0.3{mu}m-GaAs/100{Angstrom}-GaInP/GaAs(001), is analyzed. 15 refs., 6 figs.

  4. Improved Protocol for Rapid Identification of Certain Spa Types Using High Resolution Melting Curve Analysis

    PubMed Central

    Mayerhofer, Benjamin; Stöger, Anna; Pietzka, Ariane T.; Fernandez, Haizpea Lasa; Prewein, Bernhard; Sorschag, Sieglinde; Kunert, Renate; Allerberger, Franz; Ruppitsch, Werner

    2015-01-01

    Methicillin-resistant Staphylococcus aureus is one of the most significant pathogens associated with health care. For efficient surveillance, control and outbreak investigation, S. aureus typing is essential. A high resolution melting curve analysis was developed and evaluated for rapid identification of the most frequent spa types found in an Austrian hospital consortium covering 2,435 beds. Among 557 methicillin-resistant Staphylococcus aureus isolates 38 different spa types were identified by sequence analysis of the hypervariable region X of the protein A gene (spa). Identification of spa types through their characteristic high resolution melting curve profiles was considerably improved by double spiking with genomic DNA from spa type t030 and spa type t003 and allowed unambiguous and fast identification of the ten most frequent spa types t001 (58%), t003 (12%), t190 (9%), t041 (5%), t022 (2%), t032 (2%), t008 (2%), t002 (1%), t5712 (1%) and t2203 (1%), representing 93% of all isolates within this hospital consortium. The performance of the assay was evaluated by testing samples with unknown spa types from the daily routine and by testing three different high resolution melting curve analysis real-time PCR instruments. The ten most frequent spa types were identified from all samples and on all instruments with 100% specificity and 100% sensitivity. Compared to classical spa typing by sequence analysis, this gene scanning assay is faster, cheaper and can be performed in a single closed tube assay format. Therefore it is an optimal screening tool to detect the most frequent endemic spa types and to exclude non-endemic spa types within a hospital. PMID:25768007

  5. Gingival recession: prevalence and risk indicators among young greek adults

    PubMed Central

    2014-01-01

    Objectives: The aim of the current research was to assess the prevalence of gingival recession and to investigate possible associations among this condition, periodontal and epidemiological variables in a sample of young Greek adults in a general dental practice. Material and Methods: A total of 1,430 young adults was examined clinically and interviewed regarding several periodontal and epidemiological variables. Collected data included demographic variables, oral hygiene habits and smoking status. Clinical examination included the recording of dental plaque, supragingival calculus presence, gingival status and buccal gingival recession. Multivariate logistic regression analysis model was performed to access the possible association between gingival recession and several periodontal and epidemiological variables as potential risk factors. Results: The overall prevalence of gingival recession was 63.9%. The statistical analysis indicated that higher educational level [OR= 2.12, 95% CI= 0.53-8.51], cigarette smoking [OR= 1.97, 95% CI= 1.48-7.91], frequent tooth brushing [OR= 0.98, 95% CI= 0.56-1.96], presence of oral piercing [OR= 0.92, 95% CI= 0.38-1.58], presence of gingival inflammation [OR= 4.54, 95% CI= 1.68-7.16], presence of dental plaque [OR= 1.67, 95% CI= 0.68-2.83] and presence of supragingival calculus [OR=1.34, 95% CI= 0.59-1.88], were the most important associated factors of gingival recession. Conclusions: The observations of the current research supported the results from previous authors that several periodontal factors, educational level and smoking were significantly associated with the presence of gingival recession, while presence of oral piercing was a new factor that was found to be associated with gingival recession. Key words:Gingival recession, prevalence, risk factors, young adults. PMID:25136424

  6. In-plane vibration analysis of curved carbon nanotubes conveying fluid embedded in viscoelastic medium

    NASA Astrophysics Data System (ADS)

    Ghavanloo, Esmaeal; Rafiei, Masoud; Daneshmand, Farhang

    2011-05-01

    The effect of the induced vibrations in the carbon nanotubes (CNTs) arising from the internal fluid flow is a critical issue in the design of CNT-based fluidic devices. In this study, in-plane vibration analysis of curved CNTs conveying fluid embedded in viscoelastic medium is investigated. The CNT is modeled as a linear elastic cylindrical tube where the internal moving fluid is characterized by steady flow velocity and mass density of fluid. A modified-inextensible theory is used in formulation and the steady-state initial forces due to the centrifugal and pressure forces of the internal fluid are also taken into account. The finite element method is used to discretize the equation of motion and the frequencies are obtained by solving a quadratic eigenvalue problem. The effects of CNT opening angle, the elastic modulus and the damping factor of the viscoelastic surrounded medium and fluid velocity on the resonance frequencies are elucidated. It is shown that curved CNTs are unconditionally stable even for a system with sufficiently high flow velocity. The most results presented in this investigation have been absent from the literature for fluid-induced vibration of curved CNTs embedded in viscoelastic foundations.

  7. Image-plane Analysis of n-point-mass Lens Critical Curves and Caustics

    E-print Network

    Danek, Kamil

    2015-01-01

    The interpretation of gravitational microlensing events caused by planetary systems or multiple stars is based on the n-point mass lens model. The first planets detected by microlensing were well described by the two-point-mass model of a star with one planet. By the end of 2014, four events involving three-point-mass lenses had been announced. Two of the lenses were stars with two planetary companions each; two were binary stars with a planet orbiting one component. While the two-point-mass model is well understood, the same cannot be said for lenses with three or more components. Even the range of possible critical-curve topologies and caustic geometries of the three-point-mass lens remains unknown. In this paper we provide new tools for mapping the critical-curve topology and caustic cusp number in the parameter space of n-point-mass lenses. We perform our analysis in the image plane of the lens. We show that all contours of the Jacobian are critical curves of re-scaled versions of the lens configuration. ...

  8. Enhanced secondary analysis of survival data: reconstructing the data from published Kaplan-Meier survival curves

    PubMed Central

    2012-01-01

    Background The results of Randomized Controlled Trials (RCTs) on time-to-event outcomes that are usually reported are median time to events and Cox Hazard Ratio. These do not constitute the sufficient statistics required for meta-analysis or cost-effectiveness analysis, and their use in secondary analyses requires strong assumptions that may not have been adequately tested. In order to enhance the quality of secondary data analyses, we propose a method which derives from the published Kaplan Meier survival curves a close approximation to the original individual patient time-to-event data from which they were generated. Methods We develop an algorithm that maps from digitised curves back to KM data by finding numerical solutions to the inverted KM equations, using where available information on number of events and numbers at risk. The reproducibility and accuracy of survival probabilities, median survival times and hazard ratios based on reconstructed KM data was assessed by comparing published statistics (survival probabilities, medians and hazard ratios) with statistics based on repeated reconstructions by multiple observers. Results The validation exercise established there was no material systematic error and that there was a high degree of reproducibility for all statistics. Accuracy was excellent for survival probabilities and medians, for hazard ratios reasonable accuracy can only be obtained if at least numbers at risk or total number of events are reported. Conclusion The algorithm is a reliable tool for meta-analysis and cost-effectiveness analyses of RCTs reporting time-to-event data. It is recommended that all RCTs should report information on numbers at risk and total number of events alongside KM curves. PMID:22297116

  9. Evaluation of the formation of a junctional DNA nanostructure through annealing curve analysis.

    PubMed

    Shin, Seung Won; Park, Kyung Soo; Um, Soong Ho

    2015-02-20

    During the self-assembly of different numbers of oligonucleotides comprising junctional DNA nanostructures, a change in environmental variables (e.g., temperature or salt concentration) has a substantial influence on the final products. Further, distinctive annealing temperatures of oligonucleotides are observed depending on the state of hybridization. Here, we present an evaluation of the annealing characteristics of oligonucleotides for the formation of a simple junctional DNA nanostructure using an annealing curve analysis. This method may be useful for analyzing the formation of complex junctional DNA nanostructures. PMID:25597993

  10. Analysis of rotation curves in the framework of the gravitational suppression model.

    PubMed

    Martins, Christiane Frigerio; Salucci, Paolo

    2007-04-13

    We present an analysis of suitable rotation curves (RCs) of eight galaxies, aimed at checking the consistency and universality of the gravitational suppression (GraS) hypothesis, a phenomenological model for a new interaction between dark matter and baryons. Motivated by the puzzle of the core versus cusp distribution of dark matter in the center of halos, this hypothesis claims to reconcile the predictions from N-body Lambda cold dark matter simulations with kinematic observations. The GraS model improves the kinematic fitting residuals, but the mass parameters are unphysical and put the theory in difficulty. PMID:17501334

  11. The first light-curve analysis of eclipsing binaries observed by the INTEGRAL/OMC

    E-print Network

    P. Zasche

    2008-04-24

    Three Algol-type binaries in Cygnus constellation were selected for an analysis from a huge database of observations made by the INTEGRAL/OMC camera. These data were processed and analyzed, resulting in a first light-curve study of these neglected eclipsing binaries. The temperatures of the primary components range from 9500 K to 10500 K and the inclinations are circa 73deg (for PV Cyg and V1011 Cyg), while almost 90deg for V822 Cyg. All of them seem to be main-sequence stars, well within their critical Roche lobes. Nevertheless, further detailed analyses are still needed.

  12. The Static and Stability Out-of-Plane Analysis of 2-D Curved Beam with Variable Curvatures

    NASA Astrophysics Data System (ADS)

    Lin, Minghan; Wang, Huiching; Lin, Kuanchung

    The out of plane static analysis and stability analysis of curved beams of variable curvature on 2-D plane are investigated. The general solutions under various loadings are demonstrated. The analytical solutions of circular, cycloid, and spiral curved beams under pure moments are shown. The analytical solutions of circle, cycloid logarithmic spiral and spiral cantilever curved beams under concentrated load are presented as well. The out-of-plane critical load of a circular ring under uniform radial load is derived. Several critical loads are derived for various out-of-plane boundary conditions. The results are compared to the result by ANSYS. The results are consistent.

  13. Antigen-antibody biorecognition events as discriminated by noise analysis of force spectroscopy curves

    NASA Astrophysics Data System (ADS)

    Bizzarri, Anna Rita; Cannistraro, Salvatore

    2014-08-01

    Atomic force spectroscopy is able to extract kinetic and thermodynamic parameters of biomolecular complexes provided that the registered unbinding force curves could be reliably attributed to the rupture of the specific complex interactions. To this aim, a commonly used strategy is based on the analysis of the stretching features of polymeric linkers which are suitably introduced in the biomolecule-substrate immobilization procedure. Alternatively, we present a method to select force curves corresponding to specific biorecognition events, which relies on a careful analysis of the force fluctuations of the biomolecule-functionalized cantilever tip during its approach to the partner molecules immobilized on a substrate. In the low frequency region, a characteristic 1/f ? noise with ? equal to one (flickering noise) is found to replace white noise in the cantilever fluctuation power spectrum when, and only when, a specific biorecognition process between the partners occurs. The method, which has been validated on a well-characterized antigen-antibody complex, represents a fast, yet reliable alternative to the use of linkers which may involve additional surface chemistry and reproducibility concerns.

  14. Nonlinear Analysis and Post-Test Correlation for a Curved PRSEUS Panel

    NASA Technical Reports Server (NTRS)

    Gould, Kevin; Lovejoy, Andrew E.; Jegley, Dawn; Neal, Albert L.; Linton, Kim, A.; Bergan, Andrew C.; Bakuckas, John G., Jr.

    2013-01-01

    The Pultruded Rod Stitched Efficient Unitized Structure (PRSEUS) concept, developed by The Boeing Company, has been extensively studied as part of the National Aeronautics and Space Administration's (NASA s) Environmentally Responsible Aviation (ERA) Program. The PRSEUS concept provides a light-weight alternative to aluminum or traditional composite design concepts and is applicable to traditional-shaped fuselage barrels and wings, as well as advanced configurations such as a hybrid wing body or truss braced wings. Therefore, NASA, the Federal Aviation Administration (FAA) and The Boeing Company partnered in an effort to assess the performance and damage arrestments capabilities of a PRSEUS concept panel using a full-scale curved panel in the FAA Full-Scale Aircraft Structural Test Evaluation and Research (FASTER) facility. Testing was conducted in the FASTER facility by subjecting the panel to axial tension loads applied to the ends of the panel, internal pressure, and combined axial tension and internal pressure loadings. Additionally, reactive hoop loads were applied to the skin and frames of the panel along its edges. The panel successfully supported the required design loads in the pristine condition and with a severed stiffener. The panel also demonstrated that the PRSEUS concept could arrest the progression of damage including crack arrestment and crack turning. This paper presents the nonlinear post-test analysis and correlation with test results for the curved PRSEUS panel. It is shown that nonlinear analysis can accurately calculate the behavior of a PRSEUS panel under tension, pressure and combined loading conditions.

  15. Antigen-antibody biorecognition events as discriminated by noise analysis of force spectroscopy curves.

    PubMed

    Bizzarri, Anna Rita; Cannistraro, Salvatore

    2014-08-22

    Atomic force spectroscopy is able to extract kinetic and thermodynamic parameters of biomolecular complexes provided that the registered unbinding force curves could be reliably attributed to the rupture of the specific complex interactions. To this aim, a commonly used strategy is based on the analysis of the stretching features of polymeric linkers which are suitably introduced in the biomolecule-substrate immobilization procedure. Alternatively, we present a method to select force curves corresponding to specific biorecognition events, which relies on a careful analysis of the force fluctuations of the biomolecule-functionalized cantilever tip during its approach to the partner molecules immobilized on a substrate. In the low frequency region, a characteristic 1/f (?) noise with ? equal to one (flickering noise) is found to replace white noise in the cantilever fluctuation power spectrum when, and only when, a specific biorecognition process between the partners occurs. The method, which has been validated on a well-characterized antigen-antibody complex, represents a fast, yet reliable alternative to the use of linkers which may involve additional surface chemistry and reproducibility concerns. PMID:25073811

  16. Cooling Curve Analysis as an Alternative to Dilatometry in Continuous Cooling Transformations

    NASA Astrophysics Data System (ADS)

    Gibbs, John W.; Schlacher, Christian; Kamyabi-Gol, Ata; Mayr, Peter; Mendez, Patricio F.

    2015-01-01

    Dilatometry and cooling curve analysis (CCA) are two methods of determining the evolution of a phase transformation with temperature. The two methods are similar conceptual in that they take an indirect measure of the transformation and extract phase fraction information from it; however, the differences between the two methods typically makes one method better suited to analyzing a given transformation. However, without a quantitative comparison between the two methods, it is difficult to use them interchangeably. We address this by presenting a quantitative comparison of CCA and dilatometry for a martensitic transformation in a 9Cr3W3CoVNb steel. The resulting phase fraction data matches very well, within 5 K (5 °C) for any given phase fraction. This paper also extends to the quantitative methodology of calorimetry to the analysis of dilatometric data, with results comparable to ASTM A1033-10, but with expected higher accuracy by accounting by variable thermal expansion coefficients.

  17. The BVRI Light Curves And Period Analysis Of The Beta Lyrae System XX Leonis

    E-print Network

    P. Zasche; M. Wolf; P. Svoboda

    2007-11-19

    The contact eclipsing binary system XX Leonis (P = 0.97 days, sp A8) has been analysed using the PHOEBE programme, based on the Wilson Devinney code. The BVRI light curves were obtained during spring 2006 using the 20-cm telescope and ST-7 CCD detector. The effective temperature of the primary component determined from the photometric analysis is T=(7889+/-61)K, the inclination of the orbit is i=(89.98+/-2.45)deg and the photometric mass ratio q=(0.41+/-0.01). Also the third body hypothesis was suggested, based on the period analysis using 57 minimum times and resulting the period of the third body p3= (52.96+/-0.01)yr, amplitude A=(0.057+/-0.029)d and eccentricity e=(0.79+/-0.08) which gives the minimum mass m3,min=(3.6+/-0.8)M_sun.

  18. Z curve theory-based analysis of the dynamic nature of nucleosome positioning in Saccharomyces cerevisiae.

    PubMed

    Wu, Xueting; Liu, Hui; Liu, Hongbo; Su, Jianzhong; Lv, Jie; Cui, Ying; Wang, Fang; Zhang, Yan

    2013-11-01

    Nucleosome is the elementary structural unit of eukaryotic chromatin. Instability of nucleosome positioning plays critical roles in chromatin remodeling in differentiation and disease. In this study, we investigated nucleosome dynamics in the Saccharomyces cerevisiae genome using a geometric model based on Z curve theory. We identified 52,941 stable nucleosomes and 7607 dynamic nucleosomes, compiling them into a genome-wide nucleosome dynamic positioning map and constructing a user-friendly visualization platform (http://bioinfo.hrbmu.edu.cn/nucleosome). Our approach achieved a sensitivity of 90.31% and a specificity of 87.76% for S. cerevisiae. Analysis revealed transcription factor binding sites (TFBSs) were enriched in linkers. And among the sparse nucleosomes around TFBSs, dynamic nucleosomes were slightly preferred. Gene Ontology (GO) enrichment analysis indicated that stable and dynamic nucleosomes were enriched on genes involved in different biological processes and functions. This study provides an approach for comprehending chromatin remodeling and transcriptional regulation of genes. PMID:23958656

  19. The composition-explicit distillation curve technique: Relating chemical analysis and physical properties of complex fluids.

    PubMed

    Bruno, Thomas J; Ott, Lisa S; Lovestead, Tara M; Huber, Marcia L

    2010-04-16

    The analysis of complex fluids such as crude oils, fuels, vegetable oils and mixed waste streams poses significant challenges arising primarily from the multiplicity of components, the different properties of the components (polarity, polarizability, etc.) and matrix properties. We have recently introduced an analytical strategy that simplifies many of these analyses, and provides the added potential of linking compositional information with physical property information. This aspect can be used to facilitate equation of state development for the complex fluids. In addition to chemical characterization, the approach provides the ability to calculate thermodynamic properties for such complex heterogeneous streams. The technique is based on the advanced distillation curve (ADC) metrology, which separates a complex fluid by distillation into fractions that are sampled, and for which thermodynamically consistent temperatures are measured at atmospheric pressure. The collected sample fractions can be analyzed by any method that is appropriate. The analytical methods we have applied include gas chromatography (with flame ionization, mass spectrometric and sulfur chemiluminescence detection), thin layer chromatography, FTIR, corrosivity analysis, neutron activation analysis and cold neutron prompt gamma activation analysis. By far, the most widely used analytical technique we have used with the ADC is gas chromatography. This has enabled us to study finished fuels (gasoline, diesel fuels, aviation fuels, rocket propellants), crude oils (including a crude oil made from swine manure) and waste oils streams (used automotive and transformer oils). In this special issue of the Journal of Chromatography, specifically dedicated to extraction technologies, we describe the essential features of the advanced distillation curve metrology as an analytical strategy for complex fluids. PMID:20004402

  20. Algebra, Home Mortgages, and Recessions

    ERIC Educational Resources Information Center

    Mariner, Jean A. Miller; Miller, Richard A.

    2009-01-01

    The current financial crisis and recession in the United States present an opportunity to discuss relevant applications of some topics in typical first-and second-year algebra and precalculus courses. Real-world applications of percent change, exponential functions, and sums of finite geometric sequences can help students understand the problems…

  1. Black hair follicular dysplasia, an autosomal recessive condition in dogs.

    PubMed Central

    Schmutz, S M; Moker, J S; Clark, E G; Shewfelt, R

    1998-01-01

    Using histology, a coat color abnormality and the subsequent hair loss were diagnosed as black hair follicular dysplasia. A pedigree analysis of an affected litter and literature review suggests that this is inherited as an autosomal recessive trait. The melanocyte stimulating hormone receptor gene is ruled out by using linkage analysis. Images Figure 1. Figure 2. PMID:9789677

  2. Pressure calibration for the cubic press by differential thermal analysis and the high-pressure fusion curve of aluminum

    Microsoft Academic Search

    Shanmin Wang; Duanwei He; Wendan Wang; Li Lei

    2009-01-01

    Cell pressures in the cubic press have been determined by means of differential thermal analysis (DTA) based on the known fusion curve of aluminum. The results compared favorably with those of the well-known fixed-point method, based on pressure-induced phase transitions in bismuth (I–II, 2.55 GPa) and thallium (II–III, 3.68 GPa). The high-pressure fusion curve of lead was measured using our calibrated results,

  3. Determination of secondary flow morphologies by wavelet analysis in a curved artery model with physiological inflow

    NASA Astrophysics Data System (ADS)

    Bulusu, Kartik V.; Hussain, Shadman; Plesniak, Michael W.

    2014-11-01

    Secondary flow vortical patterns in arterial curvatures have the potential to affect several cardiovascular phenomena, e.g., progression of atherosclerosis by altering wall shear stresses, carotid atheromatous disease, thoracic aortic aneurysms and Marfan's syndrome. Temporal characteristics of secondary flow structures vis-à-vis physiological (pulsatile) inflow waveform were explored by continuous wavelet transform (CWT) analysis of phase-locked, two-component, two-dimensional particle image velocimeter data. Measurements were made in a 180° curved artery test section upstream of the curvature and at the 90° cross-sectional plane. Streamwise, upstream flow rate measurements were analyzed using a one-dimensional antisymmetric wavelet. Cross-stream measurements at the 90° location of the curved artery revealed interesting multi-scale, multi-strength coherent secondary flow structures. An automated process for coherent structure detection and vortical feature quantification was applied to large ensembles of PIV data. Metrics such as the number of secondary flow structures, their sizes and strengths were generated at every discrete time instance of the physiological inflow waveform. An autonomous data post-processing method incorporating two-dimensional CWT for coherent structure detection was implemented. Loss of coherence in secondary flow structures during the systolic deceleration phase is observed in accordance with previous research. The algorithmic approach presented herein further elucidated the sensitivity and dependence of morphological changes in secondary flow structures on quasiperiodicity and magnitude of temporal gradients in physiological inflow conditions.

  4. Differences in Physical Activity during School Recess

    ERIC Educational Resources Information Center

    Ridgers, Nicola D.; Saint-Maurice, Pedro F.; Welk, Gregory J.; Siahpush, Mohammad; Huberty, Jennifer

    2011-01-01

    Background: School recess provides a daily opportunity for physical activity engagement. The purpose of this study was to examine physical activity levels during recess by gender, ethnicity, and grade, and establish the contribution of recess to daily school physical activity levels. Methods: Two hundred and ten children (45% boys) from grades 3…

  5. Original article Autosomal recessive myotonia congenita

    E-print Network

    Paris-Sud XI, Université de

    , which is consistent with the hypothesis of an autosomal recessive gene responsible for the condition is due to an autosomal recessive gene (Ptacek et al, 1993). Myotonic animals are consistently heavilyOriginal article Autosomal recessive myotonia congenita in sheep GA Moore KR Dyer2 RM Dyer DP

  6. Mortality due to mental and behavioral disorders associated with the Great Recession (2008-10) in Italy: a time trend analysis.

    PubMed

    De Vogli, Roberto; Vieno, Alessio; Lenzi, Michela

    2014-06-01

    We estimated the proportion of deaths due to mental and behavioral disorders attributable to the Great Recession (2008-10) in Italy. Data on standardized death rates due to mental and behavioral disorders per 100,000 from 2000 to 2010 were provided by the Italian Health for All database. There were an additional 0.303 per 100,000 deaths per year (95% CI: 0.192, 0.478; P = 0.001) because of the crisis. Each annual decrease of €1000 in gross domestic product per capita was associated with an increase of 0.126 per 100,000 (95% CI: 0.046, 0.205; P = 0.004) deaths; every annual 1% increase in unemployment corresponded to an increase of 0.074 per 100,000 (95% CI: 0.032, 0.117; P = 0.002) deaths. PMID:24248804

  7. Wave propagation analysis in nonlinear curved single-walled carbon nanotubes based on nonlocal elasticity theory

    NASA Astrophysics Data System (ADS)

    Wang, Bo; Deng, Zichen; Ouyang, Huajiang; Zhou, Jiaxi

    2015-02-01

    Theoretical predictions are presented for wave propagation in nonlinear curved single-walled carbon nanotubes (SWCNTs). Based on the nonlocal theory of elasticity, the computational model is established, combined with the effects of geometrical nonlinearity and imperfection. In order to use the wave analysis method on this topic, a linearization method is employed. Thus, the analytical expresses of the shear frequency and flexural frequency are obtained. The effects of the geometrical nonlinearity, the initial geometrical imperfection, temperature change and magnetic field on the flexural and shear wave frequencies are investigated. Numerical results indicate that the contribution of the higher-order small scale effect on the shear deformation and the rotary inertia can lead to a reduction in the frequencies compared with results reported in the published literature. The theoretical model derived in this study should be useful for characterizing the mechanical properties of carbon nanotubes and applications of nano-devices.

  8. The Light Curve Statistical Moments Analysis: The Identification of Eclipsing Binaries

    NASA Astrophysics Data System (ADS)

    Graczyk, D.; Eyer, L.

    2010-06-01

    A semi-automatic method of identifying eclipsing binaries in large photometric surveys, based on the analysis of the light curve statistical moments, is presented. This method was tested on the OGLE-II database of variable stars in the Large Magellanic Cloud. As a result 99.0% of eclipsing binaries in Wyrzykowski et al. (2003) catalog and 100% of eclipsing binaries in Groenewegen (2005) catalog were recovered. Additionally we identified 752 new eclipsing binaries in the LMC that were not presented in earlier catalogs thereby increasing detection rates by about 25%. The method is more focusing on detached and semi-detached eclipsing binaries. We conclude that this method is well suited for use in eclipsing binary searches of large surveys such as OGLE-III.

  9. Increasing the accuracy of mass isotopomer analysis through calibration curves constructed using biologically synthesized compounds.

    PubMed

    Shen, Tie; Shen, Weiqun; Xiong, Ying; Liu, Haiyan; Zheng, Haoran; Zhou, Hong; Rui, Bin; Liu, Jianping; Wu, Jihui; Shi, Yunyu

    2009-07-01

    Mass isotopomer analysis is an important technique to measure the production and flow of metabolites in living cells, tissues, and organisms. This technique depends on accurate quantifications of different mass isotopomers using mass spectrometry. Constructing calibration curves using standard samples is the most universal approach to convert raw mass spectrometry measurements into quantitative distributions of mass isotopomers. Calibration curve approach has been, however, of very limited use in comprehensive analyses of biological systems, mainly suffering from the lack of extensive range of standard samples with accurately known isotopic enrichment. Here, we present a biological method capable of synthesizing specifically labeled amino acids. These amino acids have well-determined and estimable mass isotopomer distributions and thus can serve as standard samples. In this method, the bacterium strain Methylobacterium salsuginis sp. nov. was cultivated with partially 13C-labeled methanol as the only carbon source to produce 13C-enriched compounds. We show that the mass isotopomer distributions of the various biosynthesized amino acids are well determined and can be reasonably estimated based on proposed binomial approximation if the labeling state of the biomass reached an isotopic steady state. The interference of intramolecular inhomogeneity of 13C isotope abundances caused by biological isotope fractionation was eliminated by estimating average 13C isotope abundance. Further, the predictions are tested experimentally by mass spectrometry (MS) spectra of the labeled glycine, alanine, and aspartic acid. Most of the error in mass spectrometry measurements was less than 0.74 mol% in the test case, significantly reduced as compared with uncalibrated results, and this error is expected to be less than 0.4 mol% in real experiment as revealed by theoretical analysis. PMID:19370770

  10. Management of the Spring Snowmelt Recession in Regulated Systems

    NASA Astrophysics Data System (ADS)

    Yarnell, S. M.; Lind, A.; Epke, G.; Viers, J. H.

    2013-12-01

    In unregulated rivers in the Sierra Nevada mountains of California, the spring snowmelt recession links high winter flows to low summer baseflow and is a consistent and predictable portion of the annual hydrograph. Consequently, it is an important resource to both riverine ecosystems and California's water supply. In regulated river systems where the spring snowmelt recession is often captured behind dams or diverted for hydropower, restoration of a more natural spring flow regime can provide distinct ecological benefits, such as breeding and migration cues for native species, increased habitat availability, and greater hydraulic habitat diversity. However, knowledge of how to create and manage an ecologically beneficial spring snowmelt recession in a regulated river system has been lacking. This study defined a methodology by which spring flow regimes can be modeled in regulated systems from the quantifiable characteristics of spring snowmelt recessions in unregulated rivers. Using fundamental flow components such as magnitude, timing, and rate of change, the spring snowmelt recession in eight unregulated rivers across the Sierra Nevada range was quantified to gain a better understanding of the predictability and variability across watersheds. The analysis found that unregulated Sierran systems behaved similarly with respect to seasonal patterns and flow recession shape (i.e., recession limb curvature), and thus flows could be modeled in a manner that mimics those predictable characteristics. Using this methodology that quantifies spring recession flows in terms of a daily percent decrease in flow, a series of flow recession scenarios were then created for application on a regulated Sierran river. Four scenarios, ranging from a slow natural recession to a short fast recession typically observed in regulated rivers following cessation of high flow spills, were evaluated within a 2D hydrodynamic model. The effects of the flows on suitable habitat for Foothill yellow-legged frogs, a California species of special concern, were evaluated, and the distribution and diversity of hydraulic habitat through time was assessed. Using a spatial niche approach, the hydraulic habitat conditions were considered with regard to native aquatic species guilds, and the effects of each flow scenario on aquatic biodiversity were determined. The modeling results show that flow recessions with slow ramping rates similar to those observed in unregulated systems (less than 10% per day) were protective of frog egg masses, while flows that receded at rates greater than 10% per day resulted in desiccation of egg masses and potential stranding of newly hatched tadpoles. Furthermore, recession rates of less than 10% per day provided the most diverse hydraulic habitat for an appropriate duration in spring to support all native species guilds and maximize aquatic biodiversity. The predictive flow model described in this study has recently been applied within the Federal Energy Regulatory Commission hydropower relicensing process on the Yuba River to create flow recessions that more naturally transition from high spill flows to minimum instream flows, and is readily adaptable to other snowmelt regions with knowledge of regional unregulated flow characteristics.

  11. Statistical model to perform error analysis of curve fits of wind tunnel test data using the techniques of analysis of variance and regression analysis

    NASA Technical Reports Server (NTRS)

    Alston, D. W.

    1981-01-01

    The considered research had the objective to design a statistical model that could perform an error analysis of curve fits of wind tunnel test data using analysis of variance and regression analysis techniques. Four related subproblems were defined, and by solving each of these a solution to the general research problem was obtained. The capabilities of the evolved true statistical model are considered. The least squares fit is used to determine the nature of the force, moment, and pressure data. The order of the curve fit is increased in order to delete the quadratic effect in the residuals. The analysis of variance is used to determine the magnitude and effect of the error factor associated with the experimental data.

  12. The gene mutated in autosomal recessive polycystic kidney disease encodes a large, receptor-like protein

    Microsoft Academic Search

    Christopher J. Ward; Marie C. Hogan; Sandro Rossetti; Denise Walker; Tam Sneddon; Xiaofang Wang; Vicky Kubly; Julie M. Cunningham; Robert Bacallao; Masahiko Ishibashi; Dawn S. Milliner; Vicente E. Torres; Peter C. Harris

    2002-01-01

    Autosomal recessive polycystic kidney disease (ARPKD) is characterized by dilation of collecting ducts and by biliary dysgenesis and is an important cause of renal- and liver-related morbidity and mortality. Genetic analysis of a rat with recessive polycystic kidney disease revealed an orthologous relationship between the rat locus and the ARPKD region in humans; a candidate gene was identified. A mutation

  13. VizieR Online Data Catalog: GRB Swift X-ray light curves analysis (Margutti+, 2013)

    NASA Astrophysics Data System (ADS)

    Margutti, R.; Zaninoni, E.; Bernardini, M. G.; Chincarini, G.; Pasotti, F.; Guidorzi, C.; Angelini, L.; Burrows, D. N.; Capalbi, M.; Evans, P. A.; Gehrels, N.; Kennea, J.; Mangano, V.; Moretti, A.; Nousek, J.; Osborne, J. P.; Page, K. L.; Perri, M.; Racusin, J.; Romano, P.; Sbarufatti, B.; Stafford, S.; Stamatikos, M.

    2013-11-01

    We present a comprehensive statistical analysis of Swift X-ray light curves of gamma-ray bursts (GRBs) collecting data from more than 650 GRBs discovered by Swift and other facilities. The unprecedented sample size allows us to constrain the rest-frame X-ray properties of GRBs from a statistical perspective, with particular reference to intrinsic time-scales and the energetics of the different light-curve phases in a common rest-frame 0.3-30keV energy band. Temporal variability episodes are also studied and their properties constrained. Two fundamental questions drive this effort: (i) Does the X-ray emission retain any kind of 'memory' of the prompt ?-ray phase? (ii) Where is the dividing line between long and short GRB X-ray properties? We show that short GRBs decay faster, are less luminous and less energetic than long GRBs in the X-rays, but are interestingly characterized by similar intrinsic absorption. We furthermore reveal the existence of a number of statistically significant relations that link the X-ray to prompt ?-ray parameters in long GRBs; short GRBs are outliers of the majority of these two-parameter relations. However and more importantly, we report on the existence of a universal three-parameter scaling that links the X-ray and the ?-ray energy to the prompt spectral peak energy of both long and short GRBs: EX,iso{prop.to}E1.00+/-0.06?,iso/E0.60+/-0.10pk. (3 data files).

  14. RA/DA cumulative curve analysis of local and diffuse neuroretinal rim area damage in glaucoma patients

    PubMed Central

    Rolando, M.; Macri, A.; Iester, M.; Altieri, M.; Calabria, G.

    1998-01-01

    AIM—To evaluate the validity of cumulative rim/disc area (RA/DA) curve analysis as a clinical tool for the identification of glaucoma induced optic disc pathology.?METHODS—71 normal and 83 glaucomatous eyes were evaluated from a series of 154 subjects recruited for this study. For each eye, the cumulative distribution of RA/DA was calculated from 36 equally spaced rim sectors of each optic disc obtained by the automatic evaluation of simultaneous videographics (Image-net X Rev.3/51b). To increase the sensitivity of this analysis in early glaucoma and in normal eyes, these cumulative curves were subsequently divided into two equal segments and the slopes of their respective regression lines compared.?RESULTS—The median RA/DA value obtained from the 36 sectors was significantly different in glaucomatous eyes compared with normals (p <0.001). Nevertheless, the curves (5th-95th percentile of the cumulative curves distribution) of early glaucomatous eyes fell within the normal range. When the cumulative curve of these marginal cases was then divided into two equal segments, the comparison of the slopes of the regression lines showed a significant difference (p <0.05) in 100% of early glaucomatous eyes. Furthermore, normal eyes were shown to be true negatives in 93% of the cases in which no significant difference between the two slopes was observed.?CONCLUSION—Analysis of the RA/DA cumulative curve from 36 sectors of the optic disc was a valid method for the identification of glaucomatous disc pathology; however, a further calculation of the slopes of the two RA/DA regression lines was needed to identify early glaucomatous damage. ?? Keywords: glaucoma; optic disc morphometry; rim/disc area cumulative curves PMID:9924369

  15. MOST light-curve analysis of the ? Doradus pulsator HR 8799, showing resonances and amplitude variations

    NASA Astrophysics Data System (ADS)

    Sódor, Á.; Chené, A.-N.; De Cat, P.; Bognár, Zs.; Wright, D. J.; Marois, C.; Walker, G. A. H.; Matthews, J. M.; Kallinger, T.; Rowe, J. F.; Kuschnig, R.; Guenther, D. B.; Moffat, A. F. J.; Rucinski, S. M.; Sasselov, D.; Weiss, W. W.

    2014-08-01

    Context. The central star of the HR 8799 system is a ? Doradus-type pulsator. The system harbours four planetary-mass companions detected by direct imaging, and is a good solar system analogue. The masses of the companions are not accurately known because the estimation depends greatly on the age of the system, which is also not known with sufficient accuracy. Asteroseismic studies of the star might help to better constrain the age of HR 8799. We organized an extensive photometric and multi-site spectroscopic observing campaign to study the pulsations of the central star. Aims: The aim of the present study is to investigate the pulsation properties of HR 8799 in detail via the ultra-precise 47 d nearly continuous photometry obtained with the Microvariability and Oscillations in STars (MOST) space telescope, and to find as many independent pulsation modes as possible, which is the prerequisite for an asteroseismic age determination. Methods: We carried out Fourier analysis of the wide-band photometric time series. Results: We find that resonance and sudden amplitude changes characterize the pulsation of HR 8799. The dominant frequency is always at f1 = 1.978 d-1.Many multiples of one-ninth of the dominant frequency appear in the Fourier spectrum of the MOST data: n/9 f1, where n = {1,2,3,4,5,6,7,8,9,10,13,14,17,18}. Our analysis also reveals that many of these peaks show strong amplitude decrease and phase variations even on the 47 d time scale. The dependencies between the pulsation frequencies of HR 8799 make the planned subsequent asteroseismic analysis rather difficult. We point out some resemblance between the light curve of HR 8799 and the modulated pulsation light curves of Blazhko RR Lyrae stars. Based on data from the MOST satellite, a Canadian Space Agency mission, jointly operated by Dynacon Inc., the University of Toronto Institute for Aerospace Studies and the University of British Columbia, with the assistance of the University of Vienna.

  16. Biological analysis of Jeffrey nanofluid in a curved channel with heat dissipation.

    PubMed

    Maraj, E N; Akbar, Noreen Sher; Nadeem, S

    2014-12-01

    This study examines the peristaltic flow of Jeffrey nanofluid in a curved channel. The governing equations of Jeffrey nanofluid model for curved channel are derived including the effects of curvature. The highly nonlinear partial differential equations are simplified by using the long wave length and low Reynolds number assumptions. The reduced nonlinear partial differential equations are solved analytically with the help of homotopy perturbation method. The expression for pressure rise is computed through numerical integration. The physical features of pertinent parameters have been discussed by plotting the graphs of pressure rise, velocity, temperature, nanoparticle volume fraction and stream functions. It is observed that the curve-ness of the channel decreases the pressure rise in the peristaltic pumping region. Moreover, curve-ness of the channel effects the fluid flow by decreasing the fluid velocity near inner wall and increasing the velocity near the outer wall of the channel. PMID:25122841

  17. Flow Curve Analysis of 17-4 PH Stainless Steel under Hot Compression Test

    NASA Astrophysics Data System (ADS)

    Mirzadeh, Hamed; Najafizadeh, Abbas; Moazeny, Mohammad

    2009-12-01

    The hot compression behavior of a 17-4 PH stainless steel (AISI 630) has been investigated at temperatures of 950 °C to 1150 °C and strain rates of 10-3 to 10 s-1. Glass powder in the Rastegaev reservoirs of the specimen was used as a lubricant material. A step-by-step procedure for data analysis in the hot compression test was given. The work hardening rate analysis was performed to reveal if dynamic recrystallization (DRX) occurred. Many samples exhibited typical DRX stress-strain curves with a single peak stress followed by a gradual fall toward the steady-state stress. At low Zener-Hollomon ( Z) parameter, this material showed a new DRX flow behavior, which was called multiple transient steady state (MTSS). At high Z, as a result of adiabatic deformation heating, a drop in flow stress was observed. The general constitutive equations were used to determine the hot working constants of this material. Moreover, after a critical discussion, the deformation activation energy of 17-4 PH stainless steel was determined as 337 kJ/mol.

  18. THE XMM-NEWTON/EPIC X-RAY LIGHT CURVE ANALYSIS OF WR 6

    SciTech Connect

    Ignace, R. [Department of Physics and Astronomy, East Tennessee State University, Johnson City, TN 37663 (United States); Gayley, K. G. [Department of Physics and Astronomy, University of Iowa, Iowa City, IA 52245 (United States); Hamann, W.-R.; Oskinova, L. M. [Institute for Physics and Astronomy, University Potsdam, D-14476 Potsdam (Germany); Huenemoerder, D. P. [Massachusetts Institute of Technology, Kavli Institute for Astrophysics and Space Research, 70 Vassar Street, Cambridge, MA 02139 (United States); Pollock, A. M. T. [European Space Agency XMM-Newton Science Operations Centre, European Space Astronomy Centre, Apartado 78, Villanueva de la Cañada, E-28691 Madrid (Spain); McFall, M., E-mail: ignace@etsu.edu [Department of Physics, 191 W. Woodruff Avenue, Ohio State University, Columbus, OH 43210 (United States)

    2013-09-20

    We obtained four pointings of over 100 ks each of the well-studied Wolf-Rayet star WR 6 with the XMM-Newton satellite. With a first paper emphasizing the results of spectral analysis, this follow-up highlights the X-ray variability clearly detected in all four pointings. However, phased light curves fail to confirm obvious cyclic behavior on the well-established 3.766 day period widely found at longer wavelengths. The data are of such quality that we were able to conduct a search for event clustering in the arrival times of X-ray photons. However, we fail to detect any such clustering. One possibility is that X-rays are generated in a stationary shock structure. In this context we favor a corotating interaction region (CIR) and present a phenomenological model for X-rays from a CIR structure. We show that a CIR has the potential to account simultaneously for the X-ray variability and constraints provided by the spectral analysis. Ultimately, the viability of the CIR model will require both intermittent long-term X-ray monitoring of WR 6 and better physical models of CIR X-ray production at large radii in stellar winds.

  19. Non-linear multivariate curve resolution analysis of voltammetric pH titrations.

    PubMed

    Díaz Cruz, José Manuel; Sanchís, Josep; Chekmeneva, Elena; Ariño, Cristina; Esteban, Miquel

    2010-07-01

    A new chemometric approach is put forward, dealing with the non-linear behaviour observed in the multivariate curve resolution (MCR) analysis of certain overlapping voltammetric signals obtained in titrations of metal complexes where pH is progressively changed. In such cases, non-reversible reduction signals move along the potential axis as a consequence of the involvement of H(+)-ions in the electrochemical process and cause a dramatic loss of linearity, which hinders accurate MCR analysis. The method proposed is based on the least-squares fitting of peak potential vs. pH datasets to parametric linear and sigmoid functions through the decomposition of the data matrix into both a concentration profile matrix and a unit signal matrix, in a similar way as in the alternating least-squares algorithm of MCR (ALS). Such calculations are carried out through several home-made Matlab programs which are freely available as Supplementary Material of the present work. The fitted parameters, along with the evolution of resolved concentrations and potential shifts with pH, provide valuable information on the complexation/reduction processes. The method is tested first on the relatively simple Cd(II)-NTA system and then applied to the study of the binding of Cd(II)-ions by glutathione (gamma-Glu-Cys-Gly, GSH) and the phytochelatin PC(2) ((gamma-Glu-Cys)(2)-Gly). PMID:20512179

  20. An Objective Analysis of the Pressure-Volume Curve in the Acute Respiratory Distress Syndrome

    Microsoft Academic Search

    R. SCOTT HARRIS; DEAN R. HESS; JOSÉ G. VENEGAS

    2000-01-01

    To assess the interobserver and intraobserver variability in the clinical evaluation of the quasi-static pressure-volume (P-V) curve, we analyzed 24 sets of inflation and deflation P-V curves obtained from patients with ARDS. We used a recently described sigmoidal equation to curve-fit the P-V data sets and objectively define the point of maximum compliance increase of the inflation limb (P mci,i

  1. Ecological inference on bacterial succession using curve-based community fingerprint data analysis, demonstrated with rhizoremediation experiment.

    PubMed

    Mikkonen, Anu; Lappi, Kaisa; Wallenius, Kaisa; Lindström, Kristina; Suominen, Leena

    2011-12-01

    Nucleic acid-based community fingerprinting methods are valuable tools in microbial ecology, as they offer rapid and robust means to compare large series of replicates and references. To avoid the time-consuming and potentially subjective procedures of peak-based examination, we assessed the possibility to apply direct curve-based data analysis on community fingerprints produced with bacterial length heterogeneity PCR (LH-PCR). The dataset comprised 180 profiles from a 21-week rhizoremediation greenhouse experiment with three treatments and 10 sampling times. Curve-based analysis quantified the progressive effect of the plant (Galega orientalis) and the reversible effect of the contaminant (fuel oil) on bacterial succession. The major observed community shifts were assigned to changes in plant biomass and contamination level by canonical correlation analysis. A novel method to extract relative abundance data from the fingerprint curves for Shannon diversity index revealed contamination to reversibly decrease community complexity. By cloning and sequencing the fragment lengths, recognized to change in time in the averaged LH-PCR profiles, we identified Aquabacterium (Betaproteobacteria) as the putative r-strategic fuel oil degrader, and K-strategic Alphaproteobacteria growing in abundance later in succession. Curve-based community fingerprint analysis can be used for rapid data prescreening or as a robust alternative for the more heavily parameterized peak-based analysis. PMID:22066474

  2. Autosomal recessive anhidrotic ectodermal dysplasia in a large Moroccan family.

    PubMed Central

    Kabbaj, K; Baala, L; Chhoul, H; Sefiani, A

    1998-01-01

    We studied a large Moroccan family in which anhidrotic ectodermal dysplasia is transmitted as an autosomal recessive trait. Fourteen family members, both males and females, were affected and they all had a common ancestor. Linkage analysis by homozygosity mapping in this family will permit the gene localisation of this rare form of anhidrotic ectodermal dysplasia. Images PMID:9863606

  3. Nonlinearities and adaptation of color vision from sequential principal curves analysis.

    PubMed

    Laparra, Valero; Jiménez, Sandra; Camps-Valls, Gustavo; Malo, Jesús

    2012-10-01

    Mechanisms of human color vision are characterized by two phenomenological aspects: the system is nonlinear and adaptive to changing environments. Conventional attempts to derive these features from statistics use separate arguments for each aspect. The few statistical explanations that do consider both phenomena simultaneously follow parametric formulations based on empirical models. Therefore, it may be argued that the behavior does not come directly from the color statistics but from the convenient functional form adopted. In addition, many times the whole statistical analysis is based on simplified databases that disregard relevant physical effects in the input signal, as, for instance, by assuming flat Lambertian surfaces. In this work, we address the simultaneous statistical explanation of the nonlinear behavior of achromatic and chromatic mechanisms in a fixed adaptation state and the change of such behavior (i.e., adaptation) under the change of observation conditions. Both phenomena emerge directly from the samples through a single data-driven method: the sequential principal curves analysis (SPCA) with local metric. SPCA is a new manifold learning technique to derive a set of sensors adapted to the manifold using different optimality criteria. Here sequential refers to the fact that sensors (curvilinear dimensions) are designed one after the other, and not to the particular (eventually iterative) method to draw a single principal curve. Moreover, in order to reproduce the empirical adaptation reported under D65 and A illuminations, a new database of colorimetrically calibrated images of natural objects under these illuminants was gathered, thus overcoming the limitations of available databases. The results obtained by applying SPCA show that the psychophysical behavior on color discrimination thresholds, discount of the illuminant, and corresponding pairs in asymmetric color matching emerge directly from realistic data regularities, assuming no a priori functional form. These results provide stronger evidence for the hypothesis of a statistically driven organization of color sensors. Moreover, the obtained results suggest that the nonuniform resolution of color sensors at this low abstraction level may be guided by an error-minimization strategy rather than by an information-maximization goal. PMID:22845821

  4. Imaging the shallow subsurface with surface waves: dispersion curve analysis versus full waveform inversion

    NASA Astrophysics Data System (ADS)

    Andrés Pérez Solano, Carlos; Donno, Daniela; Strobbia, Claudio; Chauris, Hervé

    2014-05-01

    Seismic surface wave analysis is a standard tool in geotechnical engineering for imaging the shallow subsurface. Most current surface wave analysis methods assume a horizontally layered medium, and estimate the near-surface shear velocity profile from dispersion curves, which are picked on frequency-wavenumber (f-k) gathers and then inverted using 1D modelling approaches. Media containing high velocity contrasts and irregular lateral variations might be difficult to be handled with the local 1D approximation. For 2D model estimation, full waveform inversion (FWI) is an alternative and can estimate high resolution models. The classical FWI objective function consists of the least-squares misfit between observed and modelled shot gathers (Tarantola, 1986). Classical FWI needs an accurate initial model for achieving convergence. Data sets containing surface waves could be inverted, without falling into secondary minima, if the data contains sufficiently low frequencies and large offsets such that multi-scale and time windowing approaches can be applied. We propose to invert surface waves with an alternative FWI-based approach that uses a modified objective function. It is based on the least-squares misfit between the absolute value of the f-k transform of windowed shot gathers. We refer to this approach as the windowed-Amplitude Waveform Inversion (w-AWI). Some secondary minima problems are mitigated: the choice of an initial model is easier in w-AWI than in FWI. The alternative objective function is intermediary between the one used in the 1D inversion approach (dispersion curves) and classical FWI. As most of the phase information is neglected in w-AWI, we use it as a first step before classical FWI. This sequential inversion approach using w-AWI followed by classical FWI aims at estimating a high-resolution near-surface velocity model, by explaining the complete elastic wavefield, even when the initial velocity model is far from the exact one. The proposed approach is tested on a synthetic model with high velocity contrasts. Comparison with classical 1D inversion methods is also provided. In the observed data, late arrivals are associated to back-scattered waves, which have been shown to be useful information for near-surface imaging (Campman and Riyanti, 2007). We define an inversion strategy tailored to better exploit the information of scattered surface waves. We invert first the more energetic direct arrivals, and then the complete dataset. By using this approach, we can assess the contribution of scattered waves to the estimation of a highly contrasted velocity model.

  5. Integrated analysis on static/dynamic aeroelasticity of curved panels based on a modified local piston theory

    NASA Astrophysics Data System (ADS)

    Yang, Zhichun; Zhou, Jian; Gu, Yingsong

    2014-10-01

    A flow field modified local piston theory, which is applied to the integrated analysis on static/dynamic aeroelastic behaviors of curved panels, is proposed in this paper. The local flow field parameters used in the modification are obtained by CFD technique which has the advantage to simulate the steady flow field accurately. This flow field modified local piston theory for aerodynamic loading is applied to the analysis of static aeroelastic deformation and flutter stabilities of curved panels in hypersonic flow. In addition, comparisons are made between results obtained by using the present method and curvature modified method. It shows that when the curvature of the curved panel is relatively small, the static aeroelastic deformations and flutter stability boundaries obtained by these two methods have little difference, while for curved panels with larger curvatures, the static aeroelastic deformation obtained by the present method is larger and the flutter stability boundary is smaller compared with those obtained by the curvature modified method, and the discrepancy increases with the increasing of curvature of panels. Therefore, the existing curvature modified method is non-conservative compared to the proposed flow field modified method based on the consideration of hypersonic flight vehicle safety, and the proposed flow field modified local piston theory for curved panels enlarges the application range of piston theory.

  6. Decline Curve Analysis in Fractured Low Permeability Gas Wells in the Piceance Basin

    Microsoft Academic Search

    Stright D. H; J. I. Gordon

    1983-01-01

    Production decline curves of three representative low permeability gas wells in the Piceance Basin are analyzed. These wells produce from the Mancos ''B'', Mesaverde and Wasatch formations, respectively. It was found that long term production in these wells could be approximated using linear flow equations. This observation leads to the development of a decline curved method for predicting rate-time behavior

  7. International Planetary Patrol observations of Saturn's rings. II. Four color phase curves and their analysis

    Microsoft Academic Search

    L. W. Esposito; K. Lumme; W. D. Benton; L. J. Martin; H. M. Ferguson; D. T. Thompson; S. E. Jones

    1979-01-01

    New phase curves for Saturn's rings at an intermediate tilt angle B approx.17 ° are presented. Quantitative results for each of the A and B rings are reported in terms of the opposition effect, phase coefficient, and best logarithmic fit to the phase curve. In each of the four colors, there is no significant difference between the shape of the

  8. Product Differentiation by Analysis of DNA Melting Curves during the Polymerase Chain Reaction

    Microsoft Academic Search

    Kirk M. Ririe; Randy P. Rasmussen; Carl T. Wittwer

    1997-01-01

    A microvolume fluorometer integrated with a thermal cycler was used to acquire DNA melting curves during polymerase chain reaction by fluorescence monitoring of the double-stranded DNA specific dye SYBR Green I. Plotting fluorescence as a function of temperature as the thermal cycler heats through the dissociation temperature of the product gives a DNA melting curve. The shape and position of

  9. A New Type Curve Analysis for Shale Gas/Oil Reservoir Production Performance with Dual Porosity Linear System

    E-print Network

    Abdulal, Haider Jaffar

    2012-02-14

    ........................................................... 5 2.2 Linear Flow in Hydraulically Fractured Reservoirs ............... 8 2.3 Type Curve Analysis of Dual Porosity Reservoirs ................ 9 III DESCRIPTION OF LINEAR DUAL POROSITY MODEL .............. 11....3.4 Effect of Group of Parameters ................................ 21 4.4 Physical Parameters Sensitivity ............................................. 23 4.4.1 Effect of Hydraulic Fracture Inner Permeability .... 24 4...

  10. Student perspectives on the relationship between a curve and its tangent in the transition from Euclidean Geometry to Analysis

    Microsoft Academic Search

    Irene Biza; Constantinos Christou; Theodossios Zachariades

    2008-01-01

    The tangent line is a central concept in many mathematics and science courses. In this paper we describe a model of students’ thinking – concept images as well as ability in symbolic manipulation – about the tangent line of a curve as it has developed through students’ experiences in Euclidean Geometry and Analysis courses. Data was collected through a questionnaire

  11. A regret theory approach to decision curve analysis: A novel method for eliciting decision makers' preferences and decision-making

    Microsoft Academic Search

    Athanasios Tsalatsanis; Iztok Hozo; Andrew Vickers; Benjamin Djulbegovic

    2010-01-01

    BACKGROUND: Decision curve analysis (DCA) has been proposed as an alternative method for evaluation of diagnostic tests, prediction models, and molecular markers. However, DCA is based on expected utility theory, which has been routinely violated by decision makers. Decision-making is governed by intuition (system 1), and analytical, deliberative process (system 2), thus, rational decision-making should reflect both formal principles of

  12. Enhancing the Psychological Well-Being of Elderly Individuals through Tai Chi Exercise: A Latent Growth Curve Analysis.

    ERIC Educational Resources Information Center

    Li, Fuzhong; Duncan, Terry E.; Duncan, Susan C.; McAuley, Edward; Chaumeton, Nigel R.; Harmer, Peter

    2001-01-01

    Examined whether a Tai Chi exercise program enhanced the psychological well-being of 98 elderly individuals. Analyzed repeated measures data about participants using latent growth curve analysis. Results indicate the beneficial effects of participation in the Tai Chi program. Discusses implications related to the exercise-psychological health…

  13. Title: Titration_DB: Storage and Analysis of NMR-monitored Protein pH Titration Curves

    E-print Network

    McIntosh, Lawrence P.

    1 Title: Titration_DB: Storage and Analysis of NMR- monitored Protein pH Titration Curves' pKa values from the titration database for 1 H data........................2 Table 2: List of all ..................................................................................................................................................22 #12;2 Tables Table 1: List of all extracted `primary' pKa values from the titration database for 1

  14. Development of synthetic velocity - depth damage curves using a Weighted Monte Carlo method and Logistic Regression analysis

    NASA Astrophysics Data System (ADS)

    Vozinaki, Anthi Eirini K.; Karatzas, George P.; Sibetheros, Ioannis A.; Varouchakis, Emmanouil A.

    2014-05-01

    Damage curves are the most significant component of the flood loss estimation models. Their development is quite complex. Two types of damage curves exist, historical and synthetic curves. Historical curves are developed from historical loss data from actual flood events. However, due to the scarcity of historical data, synthetic damage curves can be alternatively developed. Synthetic curves rely on the analysis of expected damage under certain hypothetical flooding conditions. A synthetic approach was developed and presented in this work for the development of damage curves, which are subsequently used as the basic input to a flood loss estimation model. A questionnaire-based survey took place among practicing and research agronomists, in order to generate rural loss data based on the responders' loss estimates, for several flood condition scenarios. In addition, a similar questionnaire-based survey took place among building experts, i.e. civil engineers and architects, in order to generate loss data for the urban sector. By answering the questionnaire, the experts were in essence expressing their opinion on how damage to various crop types or building types is related to a range of values of flood inundation parameters, such as floodwater depth and velocity. However, the loss data compiled from the completed questionnaires were not sufficient for the construction of workable damage curves; to overcome this problem, a Weighted Monte Carlo method was implemented, in order to generate extra synthetic datasets with statistical properties identical to those of the questionnaire-based data. The data generated by the Weighted Monte Carlo method were processed via Logistic Regression techniques in order to develop accurate logistic damage curves for the rural and the urban sectors. A Python-based code was developed, which combines the Weighted Monte Carlo method and the Logistic Regression analysis into a single code (WMCLR Python code). Each WMCLR code execution provided a flow velocity-depth damage curve for a specific land use. More specifically, each WMCLR code execution for the agricultural sector generated a damage curve for a specific crop and for every month of the year, thus relating the damage to any crop with floodwater depth, flow velocity and the growth phase of the crop at the time of flooding. Respectively, each WMCLR code execution for the urban sector developed a damage curve for a specific building type, relating structural damage with floodwater depth and velocity. Furthermore, two techno-economic models were developed in Python programming language, in order to estimate monetary values of flood damages to the rural and the urban sector, respectively. A new Monte Carlo simulation was performed, consisting of multiple executions of the techno-economic code, which generated multiple damage cost estimates. Each execution used the proper WMCLR simulated damage curve. The uncertainty analysis of the damage estimates established the accuracy and reliability of the proposed methodology for the synthetic damage curves' development.

  15. Twinned principal curves

    Microsoft Academic Search

    Jos Koetsier; Ying Han; Colin Fyfe

    2004-01-01

    Principal Curves are extensions of Principal Component Analysis and are smooth curves, which pass through the middle of a data set. We extend the method so that, on pairs of data sets which have underlying non-linear correlations, we have pairs of curves which go through the ‘centre’ of data sets in such a way that the non-linear correlations between the

  16. Analysis of Curved Sandwich Panels Subjected to Combined Temperature Gradient and Mechanical Loads

    NASA Technical Reports Server (NTRS)

    Noor, Ahmed K.; Starnes, James H., Jr.; Peters, Jeanne M.

    1998-01-01

    The results of a detailed study of the nonlinear response of curved sandwich panels with composite face sheets and subjected to a temperature gradient through-the-thickness combined with mechanical loadings are presented. The analysis is based on a first-order shear-deformation Sanders-Budiansky type theory with the effects of large displacements, moderate rotations, transverse shear deformation and laminated anisotropic material behavior included. A mixed formulation is used with the fundamental unknowns consisting of the generalized displacements and the stress resultants of the panel. The nonlinear displacements, strain energy, principal strains, transverse shear stresses, transverse shear strain energy density, and their hierarchical sensitivity coefficients are evaluated. The hierarchical sensitivity coefficients measure the sensitivity of the nonlinear response to variations in the panel parameters, the effective properties of the face sheet layers and the core, and the micromechanical parameters. Numerical results are presented for cylindrical panels subjected to combined pressure loading, edge shortening or extension, edge shear and a temperature gradient through the thickness. The results show the effects of variations in the loading and the panel aspect ratio, on the nonlinear response and its sensitivity to changes in the various panel, effective layer and micromechanical parameters.

  17. Cognitive Vulnerabilities and Depression in Young Adults: An ROC Curves Analysis

    PubMed Central

    Sergi, Maria Rita; Continisio, Massimo; Tamburello, Antonino; Innamorati, Marco; Saggino, Aristide

    2013-01-01

    Objectives and Methods. The aim of the present study was to evaluate, by means of receiver operating characteristic (ROC) curves, whether cognitive vulnerabilities (CV), as measured by three well-known instruments (the Beck Hopelessness Scale, BHS; the Life Orientation Test-Revised, LOT-R; and the Attitudes Toward Self-Revised, ATS-R), independently discriminate between subjects with different severities of depression. Participants were 467 young adults (336 females and 131 males), recruited from the general population. The subjects were also administered the Beck Depression Inventory-II (BDI-II). Results. Four first-order (BHS Optimism/Low Standard; BHS Pessimism; Generalized Self-Criticism; and LOT Optimism) and two higher-order factors (Pessimism/Negative Attitudes Toward Self, Optimism) were extracted using Principal Axis Factoring analysis. Although all first-order and second-order factors were able to discriminate individuals with different depression severities, the Pessimism factor had the best performance in discriminating individuals with moderate to severe depression from those with lower depression severity. Conclusion. In the screening of young adults at risk of depression, clinicians have to pay particular attention to the expression of pessimism about the future. PMID:24058734

  18. Effect of intrinsic motivation on affective responses during and after exercise: latent curve model analysis.

    PubMed

    Shin, Myoungjin; Kim, Inwoo; Kwon, Sungho

    2014-12-01

    Understanding the relationship between affect and exercise is helpful in predicting human behavior with respect to exercise participation. The goals of the present study were to investigate individual differences in affective response during and after exercise and to identify the role of intrinsic motivation in affective changes. 30 active male college students (M age = 21.4 yr.) who regularly participated in sports activities volunteered to answer a questionnaire measuring intrinsic motivation toward running activities and performed a 20-min. straight running protocol at heavy intensity (about 70% of VO2max). Participants' affective responses were measured every 5 min. from the beginning of the run to 10 min. after completing the run. Latent curve model analysis indicated that individuals experienced different changes in affective state during exercise, moderated by intrinsic motivation. Higher intrinsic motivation was associated with more positive affect during exercise. There were no significant individual differences in the positive tendency of the participants' affective responses after exercise over time. Intrinsic motivation seems to facilitate positive feelings during exercise and encourages participation in exercise. PMID:25456247

  19. Reliability analysis of laser ultrasonics for train axle diagnostics based on model assisted POD curves

    NASA Astrophysics Data System (ADS)

    Malik, M. S.; Cavuto, A.; Martarelli, M.; Pandarese, G.; Revel, G. M.

    2014-05-01

    High speed train axles are integrated for a lifetime and it is time and resource consuming to conduct in service inspection with high accuracy. Laser ultrasonics is a proposed solution as a subset of non-contact measuring methods effective also for hard to reach areas and even recently proved to be effective using Laser Doppler Vibrometer (LDV) or air-coupled probes in reception. A reliability analysis of laser ultrasonics for this specific application is here performed. The research is mainly based on numerical study of the effect of high energy laser pulses on the surface of a steel axle and of the behavior of the ultrasonic waves in detecting possible defects. Probability of Detection (POD) concept is used as an estimated reliability of the inspection method. In particular Model Assisted Probability of Detection (MAPOD), a modified form of POD where models are used to infer results for making a decisive statistical approach of POD curve, is here adopted. This paper implements this approach by taking the inputs from limited experiments conducted on a high speed train axle using laser ultrasonics (source pulsed Nd:Yag, reception by high-frequency LDV) to calibrate a multiphysics FE model and by using the calibrated model to generate data samples statistically representative of damaged train axles. The simulated flaws are in accordance with the real defects present on the axle. A set of flaws of different depth has been modeled in order to assess the laser ultrasonics POD for this specific application.

  20. Lung cancer detection based on helical CT images using curved-surface morphology analysis

    NASA Astrophysics Data System (ADS)

    Taguchi, Hiroshi; Kawata, Yoshiki; Niki, Noboru; Satoh, Hitoshi; Ohmatsu, Hironobu; Kakinuma, Ryutaro; Eguchi, Kenji; Kaneko, Masahiro; Moriyama, Noriyuki

    1999-05-01

    Lung cancer is known as one of the most difficult cancers to cure. The detection of lung cancer in its early stage can be helpful for medical treatment to limit the danger. A conventional technique that assists the detection uses helical CT, which provides information of 3D cross sectional images of the lung. We expect that the proposed technique will increase diagnostic confidence. However, mass screening based on helical CT images leads to a considerable number of images for the diagnosis, this time-consuming fact makes it difficult to be used in the clinic. To increase the efficiency of the mass screening process, we had proposed a computer-aided diagnosis (CAD). In this paper, we describe lung cancer detection based on helical CT Images using curved surface morphology analysis. Firstly, we extract the lung area from the original image. Secondly, we compute shape index value of the lung area. Thirdly, we extract the ROI (Region Of Interest) from the computed shape index value. Finally, we apply the diagnosis rule using neural network and detect the suspicious regions. We show here the result of our algorithm which is applied to helical CT images of 390 patients.

  1. Prenatal diagnosis for recessive dystrophic epidermolysis bullosa in 10 families by mutation and haplotype analysis in the type VII collagen gene (COL7A1).

    PubMed Central

    Christiano, A. M.; LaForgia, S.; Paller, A. S.; McGuire, J.; Shimizu, H.; Uitto, J.

    1996-01-01

    BACKGROUND: Epidermolysis bullosa (EB) is a group of heritable diseases that manifest as blistering and erosions of the skin and mucous membranes. In the dystrophic forms of EB (DEB), the diagnostic hallmark is abnormalities in the anchoring fibrils, attachment structures beneath the cutaneous basement membrane zone. The major component of anchoring fibrils is type VII collagen, and DEB has been linked to the type VII collagen gene (COL7A1) at 3p21, with no evidence for locus heterogeneity. Due to life-threatening complications and significant long-term morbidity associated with the severe, mutilating form of recessive dystrophic EB (RDEB), there has been a demand for prenatal diagnosis from families with affected offspring. MATERIALS AND METHODS: Intragenic polymorphisms in COL7A1 and flanking microsatellite markers on chromosome 3p21, as well as detection of pathogenetic mutations in families, were used to perform PCR-based prenatal diagnosis from DNA obtained by chorionic villus sampling at 10-15 weeks or amniocentesis at 12-15 weeks gestation in 10 families at risk for recurrence of RDEB. RESULTS: In nine cases, the fetus was predicted to be normal or a clinically unaffected carrier of a mutation in one allele. These predictions have been validated in nine cases by the birth of a healthy child. In one case, an affected fetus was predicted, and the diagnosis was confirmed by fetal skin biopsy. CONCLUSIONS: DNA-based prenatal diagnosis of RDEB offers an early, expedient method of testing which will largely replace the previously available invasive fetal skin biopsy at 18-20 weeks gestation. Images FIG. 1 FIG. 3 PMID:8900535

  2. 6.RP Games at Recess

    NSDL National Science Digital Library

    This is a task from the Illustrative Mathematics website that is one part of a complete illustration of the standard to which it is aligned. Each task has at least one solution and some commentary that addresses important asects of the task and its potential use. Here are the first few lines of the commentary for this task: The students in Mr. Hill’s class played games at recess. $\\hskip30pt$6 boys played soccer $\\hskip30pt$4 girls played soccer $\\hskip30pt$2 boys jumped r...

  3. Re-Analysis of the Solar Phase Curves of the Icy Galilean Satellites

    NASA Technical Reports Server (NTRS)

    Domingue, Deborah; Verbiscer, Anne

    1997-01-01

    Re-analysis of the solar phase curves of the icy Galilean satellites demonstrates that the quantitative results are dependent on the single particle scattering function incorporated into the photometric model; however, the qualitative properties are independent. The results presented here show that the general physical characteristics predicted by a Hapke model (B. Hapke, 1986, Icarus 67, 264-280) incorporating a two parameter double Henyey-Greenstein scattering function are similar to the predictions given by the same model incorporating a three parameter double Henyey-Greenstein scattering function as long as the data set being modeled has adequate coverage in phase angle. Conflicting results occur when the large phase angle coverage is inadequate. Analysis of the role of isotropic versus anisotropic multiple scattering shows that for surfaces as bright as Europa the two models predict very similar results over phase angles covered by the data. Differences arise only at those phase angles for which there are no data. The single particle scattering behavior between the leading and trailing hemispheres of Europa and Ganymede is commensurate with magnetospheric alterations of their surfaces. Ion bombardment will produce more forward scattering single scattering functions due to annealing of potential scattering centers within regolith particles (N. J. Sack et al., 1992, Icarus 100, 534-540). Both leading and trailing hemispheres of Europa are consistent with a high porosity model and commensurate with a frost surface. There are no strong differences in predicted porosity between the two hemispheres of Callisto, both are consistent with model porosities midway between that deduced for Europa and the Moon. Surface roughness model estimates predict that surface roughness increases with satellite distance from Jupiter, with lunar surface roughness values falling midway between those measured for Ganymede and Callisto. There is no obvious variation in predicted surface roughness with hemisphere for any of the Galilean satellites.

  4. Evaluation of qPCR curve analysis methods for reliable biomarker discovery: bias, resolution, precision, and implications.

    PubMed

    Ruijter, Jan M; Pfaffl, Michael W; Zhao, Sheng; Spiess, Andrej N; Boggy, Gregory; Blom, Jochen; Rutledge, Robert G; Sisti, Davide; Lievens, Antoon; De Preter, Katleen; Derveaux, Stefaan; Hellemans, Jan; Vandesompele, Jo

    2013-01-01

    RNA transcripts such as mRNA or microRNA are frequently used as biomarkers to determine disease state or response to therapy. Reverse transcription (RT) in combination with quantitative PCR (qPCR) has become the method of choice to quantify small amounts of such RNA molecules. In parallel with the democratization of RT-qPCR and its increasing use in biomedical research or biomarker discovery, we witnessed a growth in the number of gene expression data analysis methods. Most of these methods are based on the principle that the position of the amplification curve with respect to the cycle-axis is a measure for the initial target quantity: the later the curve, the lower the target quantity. However, most methods differ in the mathematical algorithms used to determine this position, as well as in the way the efficiency of the PCR reaction (the fold increase of product per cycle) is determined and applied in the calculations. Moreover, there is dispute about whether the PCR efficiency is constant or continuously decreasing. Together this has lead to the development of different methods to analyze amplification curves. In published comparisons of these methods, available algorithms were typically applied in a restricted or outdated way, which does not do them justice. Therefore, we aimed at development of a framework for robust and unbiased assessment of curve analysis performance whereby various publicly available curve analysis methods were thoroughly compared using a previously published large clinical data set (Vermeulen et al., 2009) [11]. The original developers of these methods applied their algorithms and are co-author on this study. We assessed the curve analysis methods' impact on transcriptional biomarker identification in terms of expression level, statistical significance, and patient-classification accuracy. The concentration series per gene, together with data sets from unpublished technical performance experiments, were analyzed in order to assess the algorithms' precision, bias, and resolution. While large differences exist between methods when considering the technical performance experiments, most methods perform relatively well on the biomarker data. The data and the analysis results per method are made available to serve as benchmark for further development and evaluation of qPCR curve analysis methods (http://qPCRDataMethods.hfrc.nl). PMID:22975077

  5. BEER Analysis of Kepler and CoRoT Light Curves. II. Evidence for Superrotation in the Phase Curves of Three Kepler Hot Jupiters

    NASA Astrophysics Data System (ADS)

    Faigler, S.; Mazeh, T.

    2015-02-01

    We analyzed the Kepler light curves of four transiting hot Jupiter systems—KOI-13, HAT-P-7, TrES-2, and Kepler-76, which show BEaming, Ellipsoidal, and Reflection (BEER) phase modulations. The mass of the four planets can be estimated from either the beaming or the ellipsoidal amplitude, given the mass and radius of their parent stars. For KOI-13, HAT-P-7, and Kepler-76 we find that the beaming-based planetary mass estimate is larger than the mass estimated from the ellipsoidal amplitude, consistent with previous studies. This apparent discrepancy may be explained by equatorial superrotation of the planet atmosphere, which induces an angle shift of the planet reflection/emission phase modulation, as was suggested for Kepler-76 in the first paper of this series. We propose a modified BEER model that supports superrotation, assuming either a Lambertian or geometric reflection/emission phase function, and provides a photometry-consistent estimate of the planetary mass. Our analysis shows that for Kepler-76 and HAT-P-7, the Lambertian superrotation BEER model is highly preferable over an unshifted null model, while for KOI-13 it is preferable only at a 1.4? level. For TrES-2 we do not find such preference. For all four systems the Lambertian superrotation model mass estimates are in excellent agreement with the planetary masses derived from, or constrained by, radial velocity measurements. This makes the Lambertian superrotation BEER model a viable tool for estimating the masses of hot Jupiters from photometry alone. We conclude that hot Jupiter superrotation may be a common phenomenon that can be detected in the visual light curves of Kepler.

  6. Ogive Curves

    NSDL National Science Digital Library

    2008-01-01

    This page contains a discussion of ogive curves, logistic regression curves, and architecture. Nice photographs of architectural applications are included. The classic Birthday Problems is included as an example of an ogive curve.

  7. Analytical approximation for the recession of a sloping aquifer

    NASA Astrophysics Data System (ADS)

    Hogarth, W. L.; Li, L.; Lockington, D. A.; Stagnitti, F.; Parlange, M. B.; Barry, D. A.; Steenhuis, T. S.; Parlange, J.-Y.

    2014-11-01

    An approximation is obtained for the recession of a sloping aquifer. The analytical approximation can provide a useful tool to analyze data and obtain physical properties of the aquifer. In contrast to the case of a horizontal aquifer, when plotting the time derivative of the flux versus the flux on a log scale, the result shows that the flux derivative reaches a minimum value and that the curve can have a slope of unity as often observed. Illustration of the application of the analytical results to the Mahantango Creek data is also discussed.

  8. Measuring recession severity and its impact on healthcare expenditure.

    PubMed

    Keegan, Conor; Thomas, Steve; Normand, Charles; Portela, Conceição

    2013-06-01

    The financial crisis that manifested itself in late 2007 resulted in a Europe-wide economic crisis by 2009. As the economic climate worsened, Governments and households were put under increased strain and more focus was placed on prioritising expenditures. Across European countries and their heterogeneous health care systems, this paper examines the initial responsiveness of health expenditures to the crisis and whether recession severity can be considered a predictor of health expenditure growth. In measuring severity we move away from solely gross domestic product (GDP) as a metric and construct a recession severity index predicated on a number of key macroeconomic indicators. We then regress this index on measures of total, public and private health expenditure to identify potential relationships. Analysis suggests that for 2009, the Baltic States, along with Ireland, Italy and Greece, experienced comparatively severe recessions. We find, overall, an initial counter-cyclical response in health spending (both public and private) across countries. However, our analysis finds evidence of a negative relationship between recession severity and changes in certain health expenditures. As a predictor of health expenditure growth in 2009, the derived index is an improvement over GDP change alone. PMID:23417124

  9. International planetary patrol observations of Saturn's rings. II - Four color phase curves and their analysis

    NASA Technical Reports Server (NTRS)

    Esposito, L. W.; Lumme, K.; Benton, W. D.; Martin, L. J.; Ferguson, H. M.; Thompson, D. T.; Jones, S. E.

    1979-01-01

    New phase curves for Saturn's rings at an intermediate tilt angle B of about 17 deg are presented. Quantitative results for each of the A and B rings are reported in terms of the opposition effect, phase coefficient, and best logarithmic fit to the phase curve. There was no significant difference between the shape of the phase curves for the two rings in each of the four colors, and a four-parameter multiple scattering model of the rings was consistent with the observations. In this model, the difference in the phase curves for different colors can be explained by a variation in the single scattering albedo with wavelength. The observations allow the particles to have the same composition in the A and B rings, so that their different photometric behavior is explained by differences in optical depth and volume density in the two rings.

  10. Type curve analysis for naturally fractured reservoirs (infinite-acting reservoir case): a new approach

    E-print Network

    Angel Restrepo, Juan Alejandro

    2000-01-01

    This work introduces new type curve solutions for an unfractured well in an infinite-acting naturally fractured reservoir, including wellbore storage and skin effects. Both pseudosteady-state¹ and transient²?³ interporosity flow models are studied...

  11. Performance analysis of CNC interpolators for time-dependent feedrates along PH curves

    Microsoft Academic Search

    Yi-feng Tsai; Rida T. Farouki; Bryan Feldman

    2001-01-01

    Virtually any desired time variation V(t) of the feedrate along a curved path can be realized by real-time CNC interpolator algorithms for the Pythagorean-hodograph (PH) curves: the only stipulation is that V(t) should admit a closed-form indefinite integral F(t). Different feedrate variations V(t) can be accommodated with minimal modifications to the core algorithm by employing a modular function call to

  12. Spirometric and flow-volume curve analysis in rats, and optimal parameters for estimating obstructive impairment

    Microsoft Academic Search

    Tetsuri Kondo; Toshimori Tanigaki; Chizuko Tsuji; Hidehiro Watanabe

    2010-01-01

    We obtained flow-volume (F-V) curves in anesthetized rats by applying positive pressure on the body surface. To obtain the best curve, tracheal intubation\\u000a with either a 12 or 13 gauge catheter and a surface pressure greater than 56 cmH2O was necessary. Peak expiratory flow rate (PEFR) and forced vital capacity (FVC) were shown to be optimal parameters for\\u000a estimation of bronchoconstriction

  13. High-Throughput Genome Editing and Phenotyping Facilitated by High Resolution Melting Curve Analysis

    PubMed Central

    Thomas, Holly R.; Percival, Stefanie M.; Yoder, Bradley K.; Parant, John M.

    2014-01-01

    With the goal to generate and characterize the phenotypes of null alleles in all genes within an organism and the recent advances in custom nucleases, genome editing limitations have moved from mutation generation to mutation detection. We previously demonstrated that High Resolution Melting (HRM) analysis is a rapid and efficient means of genotyping known zebrafish mutants. Here we establish optimized conditions for HRM based detection of novel mutant alleles. Using these conditions, we demonstrate that HRM is highly efficient at mutation detection across multiple genome editing platforms (ZFNs, TALENs, and CRISPRs); we observed nuclease generated HRM positive targeting in 1 of 6 (16%) open pool derived ZFNs, 14 of 23 (60%) TALENs, and 58 of 77 (75%) CRISPR nucleases. Successful targeting, based on HRM of G0 embryos correlates well with successful germline transmission (46 of 47 nucleases); yet, surprisingly mutations in the somatic tail DNA weakly correlate with mutations in the germline F1 progeny DNA. This suggests that analysis of G0 tail DNA is a good indicator of the efficiency of the nuclease, but not necessarily a good indicator of germline alleles that will be present in the F1s. However, we demonstrate that small amplicon HRM curve profiles of F1 progeny DNA can be used to differentiate between specific mutant alleles, facilitating rare allele identification and isolation; and that HRM is a powerful technique for screening possible off-target mutations that may be generated by the nucleases. Our data suggest that micro-homology based alternative NHEJ repair is primarily utilized in the generation of CRISPR mutant alleles and allows us to predict likelihood of generating a null allele. Lastly, we demonstrate that HRM can be used to quickly distinguish genotype-phenotype correlations within F1 embryos derived from G0 intercrosses. Together these data indicate that custom nucleases, in conjunction with the ease and speed of HRM, will facilitate future high-throughput mutation generation and analysis needed to establish mutants in all genes of an organism. PMID:25503746

  14. An Analysis of the Shapes of Ultraviolet Extinction Curves. IV. Extinction without Standards

    E-print Network

    Edward L. Fitzpatrick; Derck Massa

    2005-06-17

    We present a new method for deriving UV-through-IR extinction curves, based on the use of stellar atmosphere models to provide estimates of the intrinsic (i.e., unreddened) stellar spectral energy distributions (SEDs), rather than unreddened (or lightly reddened) standard stars. We show that this ``extinction-without-standards'' technique greatly increases the accuracy of the derived extinction curves and allows realistic estimations of the uncertainties. An additional benefit of the technique is that it simultaneously determines the fundamental properties of the reddened stars themselves, making the procedure valuable for both stellar and interstellar studies. We demonstrate how the extinction-without-standards curves make it possible to: 1) study the uniformity of extinction in localized spatial regions with unprecedented precision; 2) determine the relationships between different aspects of curve morphology; 3) produce high quality extinction curves from low color excess sightlines; and 4) derive reliable extinction curves for mid-late B stars, thereby increasing spatial coverage and allowing the study of extinction in open clusters and associations dominated by such stars. The application of this technique to the available database of UV-through-IR SEDs, and to future observations, will provide valuable constraints on the nature of interstellar grains and on the processes which modify them, and will enhance our ability to remove the multi-wavelength effects of extinction from astronomical energy distributions.

  15. Analysis of Late--time Light Curves of Type IIb, Ib and Ic Supernovae

    E-print Network

    Wheeler, J Craig; Clocchiatti, A

    2014-01-01

    The shape of the light curve peak of radioactive-powered core-collapse "stripped-envelope," supernovae constrains the ejecta mass, nickel mass, and kinetic energy by the brightness and diffusion time for a given opacity and observed expansion velocity. Late-time light curves give constraints on the same parameters, given the gamma-ray opacity. Previous work has shown that the principal light curve peaks for SN IIb with small amounts of hydrogen and for hydrogen/helium-deficient SN Ib/c are often rather similar near maximum light, suggesting similar ejecta masses and kinetic energies, but that late-time light curves show a wide dispersion, suggesting a dispersion in ejecta masses and kinetic energies. It was also shown that SN IIb and SN Ib/c can have very similar late-time light curves, but different ejecta velocities demanding significantly different ejecta masses and kinetic energies. We revisit these topics by collecting and analyzing well-sampled single color and quasi-bolometric light curves from the lit...

  16. Recess Physical Activity and Perceived School Environment among Elementary School Children

    PubMed Central

    Ishii, Kaori; Shibata, Ai; Sato, Mai; Oka, Koichiro

    2014-01-01

    Differences in recess physical activity (PA) according to perceived school environment among elementary school children were examined. Participants were 103 children from two schools in Japan. PA was measured using accelerometry for seven consecutive days. Time spent in sedentary or PA (light, moderate, or vigorous) during their morning recess (25 min) and lunch recess (15 min) was determined. The School Physical Activity Environment Scale (three factors: equipment, facility, and safety) was used to investigate perceived school environment. Environmental factor scores were assigned to low or high groups for each factor by median. An analysis of covariance, with grade as the covariate, was conducted separately by gender to examine differences in PA between two groups. During lunch recess, boys in the high-equipment group spent significantly more time in moderate PA (high: 1.5; low: 0.8 min) whereas girls in this group spent less time in light PA (9.3, 11.0). Boys in the high-facility group spent significantly less time in sedentary (2.3, 3.9) and more time in vigorous PA (2.4, 1.4) during lunch recess, and girls spent more time in moderate (2.1, 1.2) and vigorous PA (1.9, 1.3) during morning recess. Differences were observed in recess PA according to school environment perceptions. The present study may be useful for further intervention studies for the promotion of PA during recess. PMID:25029495

  17. The Crucial Role of Recess in Schools

    ERIC Educational Resources Information Center

    Ramstetter, Catherine L.; Murray, Robert; Garner, Andrew S.

    2010-01-01

    Background: Recess is at the heart of a vigorous debate over the role of schools in promoting optimal child development and well-being. Reallocating time to accentuate academic concerns is a growing trend and has put recess at risk. Conversely, pressure to increase activity in school has come from efforts to combat childhood obesity. The purpose…

  18. Autosomal recessive cutis laxa syndrome revisited

    Microsoft Academic Search

    Éva Morava; Maïlys Guillard; Dirk J Lefeber; Ron A Wevers

    2009-01-01

    The clinical spectrum of the autosomal recessive cutis laxa syndromes is highly heterogeneous with respect to organ involvement and severity. One of the major diagnostic criteria is to detect abnormal elastin fibers. In several other clinically similar autosomal recessive syndromes, however, the classic histological anomalies are absent, and the definite diagnosis remains uncertain. In cutis laxa patients mutations have been

  19. Recess for Elementary School Students. Position Statement

    ERIC Educational Resources Information Center

    National Association for Sport and Physical Education, 2006

    2006-01-01

    It is the position of the National Association for Sport and Physical Education (NASPE) that all elementary school children should be provided with at least one daily period of recess of at least 20 minutes in length. Recess is an essential component of a comprehensive school physical activity program and of the total education experience for…

  20. AUTOSOMAL RECESSIVE DEFICIENCIES OF COAGULATION FACTORS

    Microsoft Academic Search

    F. Peyvandi; R. Asselta; P. M. Mannucci

    2001-01-01

    Deficiencies of coagulation factors that cause a bleeding disorder, other than factor VIII and factor IX, are inherited as autosomal recessive traits and are generally rare, with prevalence in the general population varying between 1 in 500 000 and 1 in 2 000 000. In the last few years, the number of patients with recessively transmitted coagulation deficiencies has increased

  1. The Mildest Recession: Output, Profits, and Stock Prices as the U.S. Emerges from the 2001 Recession

    Microsoft Academic Search

    William D. Nordhaus

    2002-01-01

    This paper examines the state of the United States economy as it emerges from the 2001 recession. A comparison of several central economic variables indicates that the 2001 recession was the mildest recession in the postwar period. In light of highly differentiated characteristics of recessions, the paper suggests that we differentiate among downturns by a five-category 'recession severity scale,' analogous

  2. An analysis of the shapes of ultraviolet extinction curves. II - The far-UV extinction

    NASA Technical Reports Server (NTRS)

    Fitzpatrick, Edward L.; Massa, Derck

    1988-01-01

    In this paper the properties of interstellar extinction in the far-ultraviolet region are examined utilizing IUE extinction curves for a primary data sample of 45 reddened Milky Way OB stars. These results are combined with those derived for the 2175 A bump in a previous study. It is found that IUE extinction curves can be represented by linear combinations of a Lorentzian-like 2175 A bump profile, a well-determined FUV curvature term, and an underlying linear component. The parameters of the linear component are strongly correlated and therefore only five free parameters are required to fit all of the curves in our sample. Three parameters describe the 2175 A bump, one parameter describes the linear background, and one parameter describes the strength of the FUV curvature term. The shape of the FUV curvature is found to be identical, to within the observational errors, for all the curves in the sample - which spans virtually the entire range of extinction curve morphologies observed in the Milky Way.

  3. The data mining: An analysis of 20 eclipsing binary light-curves observed by the INTEGRAL/OMC

    E-print Network

    P. Zasche

    2008-11-11

    Twenty eclipsing binaries were selected for an analysis from a huge database of observations made by the INTEGRAL/OMC camera. The photometric data were processed and analyzed, resulting in a first light-curve study of these neglected eclipsing binaries. Most of the selected systems are the detached ones. The system ET Vel was discovered to be an eccentric one. Due to missing spectroscopic study of these stars, further detailed analyses are still needed.

  4. The mathematical analysis for peristaltic flow of nano fluid in a curved channel with compliant walls

    NASA Astrophysics Data System (ADS)

    Nadeem, S.; Maraj, E. N.

    2014-01-01

    In the present paper, we have investigated the peristaltic flow of nano fluid in a curved channel with compliant walls. The governing equations of nano fluid model for curved channel are derived including the effects of curvature. The highly nonlinear partial differential equations are simplified using the long wave length and low Reynolds number assumptions. The reduced nonlinear partial differential equation is solved analytically with the help of homotopy perturbation method. The physical features of pertinent parameters have been discussed by plotting the graphs of pressure rise, velocity, temperature, nano particle volume fraction and stream functions.

  5. The Mathematical Analysis for Peristaltic Flow of Hyperbolic Tangent Fluid in a Curved Channel

    NASA Astrophysics Data System (ADS)

    Nadeem, S.; E. N., Maraj

    2013-06-01

    In the present paper, we have investigated the peristaltic flow of hyperbolic tangent fluid in a curved channel. The governing equations of hyperbolic tangent fluid model for curved channel are derived including the effects of curvature. The highly nonlinear partial differential equations are simplified by using the wave frame transformation, long wave length and low Reynolds number assumptions. The reduced nonlinear partial differential equation is solved analytically with the help of homotopy perturbation method (HPM). The physical features of pertinent parameters have been discussed by plotting the graphs of pressure rise and stream functions.

  6. Open-Mode Debonding Analysis of Curved Sandwich Panels Subjected to Heating and Cryogenic Cooling on Opposite Faces

    NASA Technical Reports Server (NTRS)

    Ko, William L.

    1999-01-01

    Increasing use of curved sandwich panels as aerospace structure components makes it vital to fully understand their thermostructural behavior and identify key factors affecting the open-mode debonding failure. Open-mode debonding analysis is performed on a family of curved honeycomb-core sandwich panels with different radii of curvature. The curved sandwich panels are either simply supported or clamped, and are subjected to uniform heating on the convex side and uniform cryogenic cooling on the concave side. The finite-element method was used to study the effects of panel curvature and boundary condition on the open-mode stress (radial tensile stress) and displacement fields in the curved sandwich panels. The critical stress point, where potential debonding failure could initiate, was found to be at the midspan (or outer span) of the inner bonding interface between the sandwich core and face sheet on the concave side, depending on the boundary condition and panel curvature. Open-mode stress increases with increasing panel curvature, reaching a maximum value at certain high curvature, and then decreases slightly as the panel curvature continues to increase and approach that of quarter circle. Changing the boundary condition from simply supported to clamped reduces the magnitudes of open-mode stresses and the associated sandwich core depth stretching.

  7. Analysis of a Kepler Light Curve of the Novalike Cataclysmic Variable KIC 8751494

    NASA Astrophysics Data System (ADS)

    Kato, Taichi; Maehara, Hiroyuki

    2013-08-01

    We analyzed a Kepler light curve of KIC 8751494, a recently recognized novalike cataclysmic variable in the Kepler field. We detected a stable periodicity of 0.114379(1) d, which we identified as being the binary's orbital period. The stronger photometric period at around 0.12245 d, which had been detected from a ground-based observation, was found to be variable, and we identified this period as the positive-superhump period. This superhump period showed short-term (10-20 d) strong variations in period most unexpectedly when the object entered a slightly faint state. The fractional superhump excess varied by as much large as ˜ 30%. The variation of the period very well traced the variation of the brightness of the system. The time-scale of this variation of superhump periods was too slow to be interpreted as a variation caused by a change of the disk radius due to thermal disk instability. We interpreted the cause of the period variation as a varying pressure effect on the period of positive superhumps. This finding suggests that the pressure effect, in at least novalike systems, plays a very important (up to ˜ 30% in the precession rate) role in producing the period of positive superhumps. We also described a possible detection of negative superhumps with a varying period of 0.1071-0.1081 d in the Q14 run of the Kepler data, and found that the variation of frequency of negative superhumps followed that of positive superhumps. The relation between the fractional superhump excesses of negative and positive superhumps can be understood if the angular frequency of positive superhumps is decreased by a pressure effect. We also found that the phase of the variation in the velocity of the emission lines reported in the earlier study is compatible with the SW Sex-type classification. Further, we introduced a new two-dimentional period analysis using least absolute shrinkage and selection operator (Lasso), and showed superior advantages of this method.

  8. An Analysis of U.S. and World Oil Production Patterns Using Hubbert-Style Curves

    Microsoft Academic Search

    Albert A. Bartlett

    2000-01-01

    A quantitative analytical method, using a spreadsheet, has been developed that allows the determination of values of the three parameters that characterize the Hubbert-style Gaussian error curve that best fits the conventional oil production data both for the U.S. and the world. The three parameters are the total area under the Gaussian, which represents the estimated ultimate (oil) recovery (EUR),

  9. An analysis of Pluto occultation light curves using an atmospheric radiative-conductive model

    NASA Astrophysics Data System (ADS)

    Zalucha, Angela M.; Gulbis, Amanda A. S.; Zhu, Xun; Strobel, Darrell F.; Elliot, J. L.

    2011-01-01

    We use a radiative-conductive model to least-squares fit Pluto stellar occultation light curve data. This model predicts atmospheric temperature based on surface temperature, surface pressure, surface radius, and CH 4 and CO mixing ratios, from which model light curves are to be calculated. The model improves upon previous techniques for deriving Pluto's atmospheric thermal structure from stellar occultation light curves by calculating temperature (as a function of height) caused by heating and cooling by species in Pluto's atmosphere, instead of a general assumption that temperature follows a power law with height or some other idealized function. We are able to fit for model surface radius, surface pressure, and CH 4 mixing ratio with one of the 2006 datasets and for surface pressure and CH 4 mixing ratio for other datasets from the years 1988, 2002, 2006, and 2008. It was not possible to fit for CO mixing ratio and surface temperature because the light curves are not sensitive to these parameters. We determine that the model surface radius, under the assumption of a stratosphere only (i.e. no troposphere) model in radiative-conductive balance, is 1180-10+20km. The CH 4 mixing ratio results are more scattered with time and are in the range of 1.8-9.4 × 10 -3. The surface pressure results show an increasing trend from 1988 to 2002, although it is not as dramatic as the factor of 2 from previous studies.

  10. Curve fitting method for modeling and analysis of photovoltaic cells characteristics

    Microsoft Academic Search

    H. Andrei; T. Ivanovici; G. Predusca; E. Diaconu; P. C. Andrei

    2012-01-01

    This paper deals with the mathematical model to assess the performances of photovoltaic (PV) cells. The PV system characteristics are modeled and analyzed by using the curve fitting method referred to the different connections of PV cells and different solar irradiance. The results are compared with those resulting from measured data in a real case. Specific LabVIEW™ and Matlab™ software

  11. Cantor versus Harley: Optimization and Analysis of Explicit Formulae for Hyperelliptic Curve Cryptosystems

    Microsoft Academic Search

    Thomas J. Wollinger; Jan Pelzl; Christof Paar

    2005-01-01

    Hyperelliptic curves (HEC) look promising for cryptographic applications, because of their short operand size compared to other public-key schemes. The operand sizes seem well suited for small processor architectures, where memory and speed are constrained. However, the group operation has been believed to be too complex and thus, HEC have not been used in this context so far. In recent

  12. Development of Oral Reading Fluency in Children with Speech or Language Impairments: A Growth Curve Analysis

    ERIC Educational Resources Information Center

    Puranik, Cynthia S.; Petscher, Yaacov; Al Otaiba, Stephanie; Catts, Hugh W.; Lonigan, Christopher J.

    2008-01-01

    This longitudinal study used piece-wise growth curve analyses to examine growth patterns in oral reading fluency for 1,991 students with speech impairments (SI) or language impairments (LI) from first through third grade. The main finding of this study was that a diagnosis of SI or LI can have a detrimental and persistent effect on early reading…

  13. Spectrophotometric analysis of GRB afterglow extinction curves with X-shooter

    E-print Network

    Japelj, J; Gomboc, A; Vergani, S D; Goldoni, P; Selsing, J; Cano, Z; D'Elia, V; Flores, H; Fynbo, J P U; Hammer, F; Hjorth, J; Jakobsson, P; Kaper, L; Kopa?, D; Krühler, T; Melandri, A; Piranomonte, S; Sánchez-Ramírez, R; Tagliaferri, G; Tanvir, N R; Postigo, A de Ugarte; Watson, D; Wijers, R A M J

    2015-01-01

    In this work we use gamma-ray burst (GRB) afterglow spectra observed with the VLT/X-shooter spectrograph to measure rest-frame extinction in GRB lines-of-sight by modeling the broadband near-infrared (NIR) to X-ray afterglow spectral energy distributions (SEDs). Our sample consists of nine Swift GRBs, eight of them belonging to the long-duration and one to the short-duration class. Dust is modeled using the average extinction curves of the Milky Way and the two Magellanic Clouds. We derive the rest-frame extinction of the entire sample, which fall in the range $0 \\lesssim {\\it A}_{\\rm V} \\lesssim 1.2$. Moreover, the SMC extinction curve is the preferred extinction curve template for the majority of our sample, a result which is in agreement with those commonly observed in GRB lines-of-sights. In one analysed case (GRB 120119A), the common extinction curve templates fail to reproduce the observed extinction. To illustrate the advantage of using the high-quality X-shooter afterglow SEDs over the photometric SED...

  14. Parent Involvement and Science Achievement: A Cross-Classified Multilevel Latent Growth Curve Analysis

    ERIC Educational Resources Information Center

    Johnson, Ursula Y.; Hull, Darrell M.

    2014-01-01

    The authors examined science achievement growth at Grades 3, 5, and 8 and parent school involvement at the same time points using the Early Childhood Longitudinal Study-Kindergarten Class of 1998-1999. Data were analyzed using cross-classified multilevel latent growth curve modeling with time invariant and varying covariates. School-based…

  15. Efficient Generation of Delay Change Curves for Noise-Aware Static Timing Analysis

    Microsoft Academic Search

    Kanak Agarwal; Yu Cao; Takashi Sato; Dennis Sylvester; Chenming Hu

    2002-01-01

    In this paper, we explore the concept of using analytical models to efficiently generate delay change curves (DCCs) that can then be used to characterize the impact of noise on any victim\\/aggressor configuration. Such an approach captures important noise considerations such as the possibility of delay change even when the switching windows of neighboring gates do not overlap. The technique

  16. Growth curves of deviant behavior in early adolescence: A multilevel analysis

    Microsoft Academic Search

    Robert A. Johnson; John P. Hoffmann; S. Susan Su; Dean R. Gerstein

    1997-01-01

    Multilevel growth curve models provide a means of analyzing individual differences in the growth of deviance, allow a number of theories to be integrated in a single model, and can help to unify research on deviant\\/delinquent\\/criminal careers at different stages of the life cycle. Building on the distinction between “population heterogeneity” and “state dependence” as alternative explanations of persistent individual

  17. Theoretical analysis of convective heat transfer of Oldroyd-B fluids in a curved pipe

    Microsoft Academic Search

    Mingkan Zhang; Xinrong Shen; Jianfeng Ma; Benzhao Zhang

    2008-01-01

    Perturbation methods are used to study steady, fully developed flow of Oldroyd-B fluids through a curved pipe of circular cross-section. A perturbation solution up to secondary order is obtained for a small value of curvature ratio. The range of validity of the perturbation method are discussed and chosen carefully. Variations of temperature distribution with Re and We are discussed in

  18. A case-acquisition and decision-support system for the analysis of group-average lactation curves.

    PubMed

    Pietersma, D; Lacroix, R; Lefebvre, D; Block, T E; Wade, K M

    2001-03-01

    A case-acquisition and decision-support system was developed to support the analysis of group-average lactation curves and to acquire example cases from domain specialists. This software was developed through several iterations of a three-step approach involving 1) problem analysis and formulation in consultation with two dairy nutrition specialists; 2) development of a case-acquisition and decision-support prototype by the system developer; and 3) use of the prototype by the domain specialists to analyze and classify milk-recording data from example herds. The overall problem was decomposed into three subproblems: removal of outlier tests and lactation curves of individual cows; interpretation of group-average lactation curves; and diagnosis of detected abnormalities at the herd level through the identification of potential management deficiencies. For each subproblem, a software module was developed allowing the user to analyze both graphical and numerical performance representations and classify these representations using predefined linguistic descriptors. The example-based method for the development of the program proved to be very useful, facilitating the communication between system developer and domain specialists, and allowing the specialists to explore the appropriateness of the various prototypes developed. The resulting software represents a formalization of the approach to group-average lactation curve analysis, elicited from the two domain specialists. In future research, the case-acquisition and decision-support system will be complemented with knowledge to automate identified classification tasks, which will be captured through the application of machine-learning techniques to example cases, acquired from domain specialists using the software. PMID:11286426

  19. A Light Curve Analysis of Classical Novae: Free-free Emission versus Photospheric Emission

    NASA Astrophysics Data System (ADS)

    Hachisu, Izumi; Kato, Mariko

    2015-01-01

    We analyzed light curves of seven relatively slower novae, PW Vul, V705 Cas, GQ Mus, RR Pic, V5558 Sgr, HR Del, and V723 Cas, based on an optically thick wind theory of nova outbursts. For fast novae, free-free emission dominates the spectrum in optical bands rather than photospheric emission, and nova optical light curves follow the universal decline law. Faster novae blow stronger winds with larger mass-loss rates. Because the brightness of free-free emission depends directly on the wind mass-loss rate, faster novae show brighter optical maxima. In slower novae, however, we must take into account photospheric emission because of their lower wind mass-loss rates. We calculated three model light curves of free-free emission, photospheric emission, and their sum for various white dwarf (WD) masses with various chemical compositions of their envelopes and fitted reasonably with observational data of optical, near-IR (NIR), and UV bands. From light curve fittings of the seven novae, we estimated their absolute magnitudes, distances, and WD masses. In PW Vul and V705 Cas, free-free emission still dominates the spectrum in the optical and NIR bands. In the very slow novae, RR Pic, V5558 Sgr, HR Del, and V723 Cas, photospheric emission dominates the spectrum rather than free-free emission, which makes a deviation from the universal decline law. We have confirmed that the absolute brightnesses of our model light curves are consistent with the distance moduli of four classical novae with known distances (GK Per, V603 Aql, RR Pic, and DQ Her). We also discussed the reason why the very slow novae are about ~1 mag brighter than the proposed maximum magnitude versus rate of decline relation.

  20. On the analysis of Canadian Holstein dairy cow lactation curves using standard growth functions.

    PubMed

    López, S; France, J; Odongo, N E; McBride, R A; Kebreab, E; AlZahal, O; McBride, B W; Dijkstra, J

    2015-04-01

    Six classical growth functions (monomolecular, Schumacher, Gompertz, logistic, Richards, and Morgan) were fitted to individual and average (by parity) cumulative milk production curves of Canadian Holstein dairy cows. The data analyzed consisted of approximately 91,000 daily milk yield records corresponding to 122 first, 99 second, and 92 third parity individual lactation curves. The functions were fitted using nonlinear regression procedures, and their performance was assessed using goodness-of-fit statistics (coefficient of determination, residual mean squares, Akaike information criterion, and the correlation and concordance coefficients between observed and adjusted milk yields at several days in milk). Overall, all the growth functions evaluated showed an acceptable fit to the cumulative milk production curves, with the Richards equation ranking first (smallest Akaike information criterion) followed by the Morgan equation. Differences among the functions in their goodness-of-fit were enlarged when fitted to average curves by parity, where the sigmoidal functions with a variable point of inflection (Richards and Morgan) outperformed the other 4 equations. All the functions provided satisfactory predictions of milk yield (calculated from the first derivative of the functions) at different lactation stages, from early to late lactation. The Richards and Morgan equations provided the most accurate estimates of peak yield and total milk production per 305-d lactation, whereas the least accurate estimates were obtained with the logistic equation. In conclusion, classical growth functions (especially sigmoidal functions with a variable point of inflection) proved to be feasible alternatives to fit cumulative milk production curves of dairy cows, resulting in suitable statistical performance and accurate estimates of lactation traits. PMID:25648814

  1. Application of multivariate curve resolution alternating least squares (MCR-ALS) to the quantitative analysis of pharmaceutical and agricultural samples.

    PubMed

    Azzouz, T; Tauler, R

    2008-02-15

    Application of multivariate curve resolution alternating least squares (MCR-ALS), for the resolution and quantification of different analytes in different type of pharmaceutical and agricultural samples is shown. In particular, MCR-ALS is applied first to the UV spectrophotometric quantitative analysis of mixtures of commercial steroid drugs, and second to the near-infrared (NIR) spectrophotometric quantitative analysis of humidity and protein contents in forage cereal samples. Quantitative results obtained by MCR-ALS are compared to those obtained using the well established partial least squares regression (PLSR) multivariate calibration method. PMID:18371770

  2. The first USH2A mutation analysis of Japanese autosomal recessive retinitis pigmentosa patients: a totally different mutation profile with the lack of frequent mutations found in Caucasian patients.

    PubMed

    Zhao, Yang; Hosono, Katsuhiro; Suto, Kimiko; Ishigami, Chie; Arai, Yuuki; Hikoya, Akiko; Hirami, Yasuhiko; Ohtsubo, Masafumi; Ueno, Shinji; Terasaki, Hiroko; Sato, Miho; Nakanishi, Hiroshi; Endo, Shiori; Mizuta, Kunihiro; Mineta, Hiroyuki; Kondo, Mineo; Takahashi, Masayo; Minoshima, Shinsei; Hotta, Yoshihiro

    2014-09-01

    Retinitis pigmentosa (RP) is a highly heterogeneous genetic disease. The USH2A gene, which accounts for approximately 74-90% of Usher syndrome type 2 (USH2) cases, is also one of the major autosomal recessive RP (arRP) causative genes among Caucasian populations. To identify disease-causing USH2A gene mutations in Japanese RP patients, all 73 exons were screened for mutations by direct sequencing. In total, 100 unrelated Japanese RP patients with no systemic manifestations were identified, excluding families with obvious autosomal dominant inheritance. Of these 100 patients, 82 were included in this present study after 18 RP patients with very likely pathogenic EYS (eyes shut homolog) mutations were excluded. The mutation analysis of the USH2A revealed five very likely pathogenic mutations in four patients. A patient had only one very likely pathogenic mutation and the others had two of them. Caucasian frequent mutations p.C759F in arRP and p.E767fs in USH2 were not found. All the four patients exhibited typical clinical features of RP. The observed prevalence of USH2A gene mutations was approximately 4% among Japanese arRP patients, and the profile of the USH2A gene mutations differed largely between Japanese patients and previously reported Caucasian populations. PMID:25078356

  3. Unlocking the potential of survival data for model organisms through a new database and online analysis platform: SurvCurv.

    PubMed

    Ziehm, Matthias; Thornton, Janet M

    2013-10-01

    Lifespan measurements, also called survival records, are a key phenotype in research on aging. If external hazards are excluded, aging alone determines the mortality in a population of model organisms. Understanding the biology of aging is highly desirable because of the benefits for the wide range of aging-related diseases. However, it is also extremely challenging because of the underlying complexity. Here, we describe SurvCurv, a new database and online resource focused on model organisms collating survival data for storage and analysis. All data in SurvCurv are manually curated and annotated. The database, available at www.ebi.ac.uk/thornton-srv/databases/SurvCurv/, offers various functions including plotting, Cox proportional hazards analysis, mathematical mortality models and statistical tests. It facilitates reanalysis and allows users to analyse their own data and compare it with the largest repository of model-organism data from published experiments, thus unlocking the potential of survival data and demographics in model organisms. PMID:23826631

  4. Barcoding melting curve analysis for rapid, sensitive, and discriminating authentication of saffron (Crocus sativus L.) from its adulterants.

    PubMed

    Jiang, Chao; Cao, Liang; Yuan, Yuan; Chen, Min; Jin, Yan; Huang, Luqi

    2014-01-01

    Saffron (Crocus sativus L.) is one of the most important and expensive medicinal spice products in the world. Because of its high market value and premium price, saffron is often adulterated through the incorporation of other materials, such as Carthamus tinctorius L. and Calendula officinalis L. flowers, Hemerocallis L. petals, Daucus carota L. fleshy root, Curcuma longa L. rhizomes, Zea may L., and Nelumbo nucifera Gaertn. stigmas. To develop a straightforward, nonsequencing method for rapid, sensitive, and discriminating detection of these adulterants in traded saffron, we report here the application of a barcoding melting curve analysis method (Bar-MCA) that uses the universal chloroplast plant DNA barcoding region trnH-psbA to identify adulterants. When amplified at DNA concentrations and annealing temperatures optimized for the curve analysis, peaks were formed at specific locations for saffron (81.92°C) and the adulterants: D. carota (81.60°C), C. tinctorius (80.10°C), C. officinalis (79.92°C), Dendranthema morifolium (Ramat.) Tzvel. (79.62°C), N. nucifera (80.58°C), Hemerocallis fulva (L.) L. (84.78°C), and Z. mays (84.33°C). The constructed melting curves for saffron and its adulterants have significantly different peak locations or shapes. In conclusion, Bar-MCA could be a faster and more cost-effective method to authenticate saffron and detect its adulterants. PMID:25548775

  5. Barcoding Melting Curve Analysis for Rapid, Sensitive, and Discriminating Authentication of Saffron (Crocus sativus L.) from Its Adulterants

    PubMed Central

    Cao, Liang; Yuan, Yuan; Chen, Min; Jin, Yan; Huang, Luqi

    2014-01-01

    Saffron (Crocus sativus L.) is one of the most important and expensive medicinal spice products in the world. Because of its high market value and premium price, saffron is often adulterated through the incorporation of other materials, such as Carthamus tinctorius L. and Calendula officinalis L. flowers, Hemerocallis L. petals, Daucus carota L. fleshy root, Curcuma longa L. rhizomes, Zea may L., and Nelumbo nucifera Gaertn. stigmas. To develop a straightforward, nonsequencing method for rapid, sensitive, and discriminating detection of these adulterants in traded saffron, we report here the application of a barcoding melting curve analysis method (Bar-MCA) that uses the universal chloroplast plant DNA barcoding region trnH-psbA to identify adulterants. When amplified at DNA concentrations and annealing temperatures optimized for the curve analysis, peaks were formed at specific locations for saffron (81.92°C) and the adulterants: D. carota (81.60°C), C. tinctorius (80.10°C), C. officinalis (79.92°C), Dendranthema morifolium (Ramat.) Tzvel. (79.62°C), N. nucifera (80.58°C), Hemerocallis fulva (L.) L. (84.78°C), and Z. mays (84.33°C). The constructed melting curves for saffron and its adulterants have significantly different peak locations or shapes. In conclusion, Bar-MCA could be a faster and more cost-effective method to authenticate saffron and detect its adulterants. PMID:25548775

  6. Light Iceland Glacier Recession 1973 to 2000

    NSDL National Science Digital Library

    Lori Perkins

    2001-04-09

    This animation shows glacier recesion at the Breidamerkurjokull glacier in Iceland. The data from 1973 is taken from Landsat 1 and the 2000 data is from Landsat 7. The Breidamerkurjokull glacier in Iceland has been measured by Landsat to be receding since 1973. The glacierologists in Iceland and here at NASAs Goddard Space Flight Center have measured the recession throughout the entire glacier and found different rates of recession in different areas. In genral, the glacier seems to be receding at about 2% annually. It is extremely controversial whether or not this recession is caused by global warming.

  7. Regional frequency analysis of extreme precipitation with consideration of uncertainties to update IDF curves for the city of Trondheim

    NASA Astrophysics Data System (ADS)

    Hailegeorgis, Teklu T.; Thorolfsson, Sveinn T.; Alfredsen, Knut

    2013-08-01

    Regional frequency analysis based on the method of L-moments is performed from annual maximum series of extreme precipitation intensity to update Intensity-Duration-Frequency (IDF) curves for the city of Trondheim. The main problems addressed are (1) reduction of uncertainties of different sources for reliable estimation of quantiles: (i) testing of trend patterns and stationarity of the data series from the target site and demonstrating the dependency of results on the data used; (ii) testing regional homogeneity of extreme precipitation events for the climate regime in the study area and “pooling” of regional data for data augmentation and reduction of uncertainty due to short length of data series; and (iii) selection of distributions for extreme precipitation events of different durations to reduce the uncertainty due to choice of distributions; and (2) assessment and quantification of sampling uncertainty in terms of interval estimates (confidence bounds) of quantiles. Trend patterns and check for stationarity were demonstrated for a data from a target site based on both non-parametric Mann-Kendall and parametric regression tests. Selection of distributions was performed based on Z-statistics and L-moment ratio diagrams. Non-parametric balanced bootstrap resampling was used to quantify the sampling uncertainty. For extreme precipitation events of shorter durations (5-30 min) there are statistically significant increasing trend patterns for the data series with start years of 1992-1998 while there are no significant trend patterns for recent extremes and there are no statistically significant trend patterns for longer durations (45-180 min). The results of the analyses indicate that: (1) significance tests for trend patterns and stationarity are dependent on the data series used but the stationarity assumption is valid for the data series used from the target site. (2) the extreme precipitation events from four sites in Trondheim are homogeneous and can be “pooled” for regional analysis; (3) different types of distributions fit to extreme precipitation events of different durations which shows that thorough selection of distributions is indispensable rather than fitting a single distribution for the whole durations; (4) interval estimates from balanced bootstrap resampling indicated that there is huge sampling uncertainty in quantile estimation that needs to be addressed in any frequency analysis; and (5) large differences are observed between the IDF curves from this study and the existing IDF curves (i.e. Imetno). The IDF curves from this study are from data augmented through regional analysis, based on thorough procedures for selection of distributions and also include uncertainty bounds and hence are more reliable than the existing one. Hence, the methods and procedures followed in this study are expected to contribute to endeavors for estimating reliable IDF curves.

  8. Fitting sediment rating curves using regression analysis: a case study of Russian Arctic rivers

    NASA Astrophysics Data System (ADS)

    Tananaev, N. I.

    2015-03-01

    Published suspended sediment data for Arctic rivers is scarce. Suspended sediment rating curves for three medium to large rivers of the Russian Arctic were obtained using various curve-fitting techniques. Due to the biased sampling strategy, the raw datasets do not exhibit log-normal distribution, which restricts the applicability of a log-transformed linear fit. Non-linear (power) model coefficients were estimated using the Levenberg-Marquardt, Nelder-Mead and Hooke-Jeeves algorithms, all of which generally showed close agreement. A non-linear power model employing the Levenberg-Marquardt parameter evaluation algorithm was identified as an optimal statistical solution of the problem. Long-term annual suspended sediment loads estimated using the non-linear power model are, in general, consistent with previously published results.

  9. Photometry, period variations and light curve analysis of eclipsing binary V1191 Cyg

    NASA Astrophysics Data System (ADS)

    Ostadnezhad, S.; Delband, M.; Hasanzadeh, A.

    2014-08-01

    New observations of the eclipsing binary system V1191 Cyg were carried out by using CCD in BVR filters and new times of light minimum and new ephemeris were obtained. For the first time, the O-C curve of this binary was analyzed by using the Kalimeris method and the orbital period and its rate of change were calculated as functions of time. The BVR light curves were analyzed using both the Binary Maker 3.0 and PHOEBE 0.31a programs to determine some geometrical and physical parameters. By analyzing O-C diagram, the period variation was calculated to be dP/dt=3.13×10-6 d yr and the rate of mass transfer was M=5.23×10-7 M yr.

  10. An Analysis of Pluto Occultation Light Curves Using an Atmospheric Radiative-conductive Model

    NASA Astrophysics Data System (ADS)

    Zalucha, Angela M.; Gulbis, A. A. S.; Zhu, X.; Strobel, D. F.; Elliot, J. L.

    2009-09-01

    Using the radiative equilibrium temperature profiles obtained from the radiative-conductive model of Strobel et al. 1996 (Icarus, 120, 266-289), we calculate a set of occultation light curves for Pluto for a range of surface pressures and methane mixing ratios, the latter of which is assumed to be constant with height. We have devised a method to interpolate a grid of model light curves in order to perform least-squares fitting to available Pluto occultation data. Fits without a troposphere and with a surface radius of 1152 km to the 2006 June 12 occultation by Pluto observed at Siding Spring (Elliot et al. 2007, AJ 134, 1-13) return a surface pressure and methane mixing ratio of 18.9 +/- 0.8 microbar and 0.0020 +/- 0.0003, respectively. Best fits to the 2002 August 21 occultation observed using the 2.24m University of Hawaii telescope (Pasachoff et al. 2005, AJ 129, 1718-1723) are 18.5 +/- 0.5 microbar and 0.0020 +/- 0.0001, respectively. For each of these fits, surface temperature and CO mixing ratio (also constant with height) were taken to be 37 K and 0.0005, respectively. The model light curves are not found to be sensitive to either of these parameters; CO mixing ratios as high as 0.02 are found to be consistent with the formal error bars on the fits above. The fitted surface pressure values are higher than those derived from the no troposphere models of Lellouch et al. 2009 (Astron. Astrophys. 495, L17-L21), while the methane mixing ratio values are lower. We will present our methodology of comparing atmospheric models to occultation data, fitting results for other stellar occultation light curves, and implications for Pluto's atmospheric structure. This work was supported in part by NASA grants NNX08AE92G, NNX07AK73G, and NNG05GO91G.

  11. Limit analysis of masonry vaults by means of curved shell finite elements and homogenization

    Microsoft Academic Search

    Enrico Milani; Gabriele Milani; Antonio Tralli

    2008-01-01

    The study of masonry vaults should take into account the essentials of the material “masonry” – i.e. heterogeneity, almost no resistance to tension combined with a good compressive strength and a high friction coefficient, as well as the overall importance of the geometry for achieving the equilibrium.In this paper, a new six-noded triangular curved element, specifically developed for the kinematic

  12. Curved Mirrors

    NSDL National Science Digital Library

    Michael Horton

    2009-05-30

    This inquiry activity will be used before discussing curved mirrors in class. Students will discover how curved mirrors act and how the size and the orientation of the image are related to the distance from the mirror. Ray diagrams for curved mirrors are

  13. Statistically generated weighted curve fit of residual functions for modal analysis of structures

    NASA Technical Reports Server (NTRS)

    Bookout, P. S.

    1995-01-01

    A statistically generated weighting function for a second-order polynomial curve fit of residual functions has been developed. The residual flexibility test method, from which a residual function is generated, is a procedure for modal testing large structures in an external constraint-free environment to measure the effects of higher order modes and interface stiffness. This test method is applicable to structures with distinct degree-of-freedom interfaces to other system components. A theoretical residual function in the displacement/force domain has the characteristics of a relatively flat line in the lower frequencies and a slight upward curvature in the higher frequency range. In the test residual function, the above-mentioned characteristics can be seen in the data, but due to the present limitations in the modal parameter evaluation (natural frequencies and mode shapes) of test data, the residual function has regions of ragged data. A second order polynomial curve fit is required to obtain the residual flexibility term. A weighting function of the data is generated by examining the variances between neighboring data points. From a weighted second-order polynomial curve fit, an accurate residual flexibility value can be obtained. The residual flexibility value and free-free modes from testing are used to improve a mathematical model of the structure. The residual flexibility modal test method is applied to a straight beam with a trunnion appendage and a space shuttle payload pallet simulator.

  14. CONFIRMATION OF HOT JUPITER KEPLER-41b VIA PHASE CURVE ANALYSIS

    SciTech Connect

    Quintana, Elisa V.; Rowe, Jason F.; Caldwell, Douglas A.; Christiansen, Jessie L.; Jenkins, Jon M.; Morris, Robert L.; Smith, Jeffrey C.; Thompson, Susan E. [SETI Institute, 189 Bernardo Ave, Suite 100, Mountain View, CA 94043 (United States); Barclay, Thomas [Bay Area Environmental Research Institute/NASA Ames Research Center, Moffett Field, CA 94035 (United States); Howell, Steve B.; Borucki, William J.; Sanderfer, Dwight T.; Still, Martin [NASA Ames Research Center, Moffett Field, CA 94035 (United States); Ciardi, David R. [NASA Exoplanet Science Institute/Caltech, 770 South Wilson Ave., MC 100-2, Pasadena, CA 91125 (United States); Demory, Brice-Olivier [Department of Earth, Atmospheric and Planetary Sciences, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139 (United States); Klaus, Todd C. [Orbital Sciences Corporation/NASA Ames Research Center, Moffett Field, CA 94035 (United States); Fulton, Benjamin J.; Shporer, Avi, E-mail: elisa.quintana@nasa.gov [Las Cumbres Observatory Global Telescope Network, 6740 Cortona Drive, Suite 102, Santa Barbara, CA 93117 (United States)

    2013-04-20

    We present high precision photometry of Kepler-41, a giant planet in a 1.86 day orbit around a G6V star that was recently confirmed through radial velocity measurements. We have developed a new method to confirm giant planets solely from the photometric light curve, and we apply this method herein to Kepler-41 to establish the validity of this technique. We generate a full phase photometric model by including the primary and secondary transits, ellipsoidal variations, Doppler beaming, and reflected/emitted light from the planet. Third light contamination scenarios that can mimic a planetary transit signal are simulated by injecting a full range of dilution values into the model, and we re-fit each diluted light curve model to the light curve. The resulting constraints on the maximum occultation depth and stellar density combined with stellar evolution models rules out stellar blends and provides a measurement of the planet's mass, size, and temperature. We expect about two dozen Kepler giant planets can be confirmed via this method.

  15. Breakthrough curve analysis of pressure swing adsorption for hydrogen isotope separation

    SciTech Connect

    Kotoh, K. [Faculty of Eng., Kyushu Univ., 744 Moto-oka, Nishi-ku, Fukuoka 819-0395 (Japan); Tanaka, M. [National Inst. for Fusion Science, 322-6 Oroshi-cho, Toki-shi, Gifu 509-5292 (Japan); Sakamoto, T.; Nakamura, Y. [Faculty of Eng., Kyushu Univ., 744 Moto-oka, Nishi-ku, Fukuoka 819-0395 (Japan); Asakura, Y.; Uda, T. [National Inst. for Fusion Science, 322-6 Oroshi-cho, Toki-shi, Gifu 509-5292 (Japan); Sugiyama, T. [Faculty of Eng., Nagoya Univ., Furo-cho, Chikusa-ku, Nagoya 464-8603 (Japan)

    2008-07-15

    For the purpose of developing an effective system for hydrogen isotope separation, we have been studying the adsorption-desorption dynamic behavior of hydrogen and deuterium in a packed-bed column with synthetic zeolites, aimed at applying the pressure swing adsorption process. The adsorption behavior of molecules in the packed-bed is reflected in the breakthrough curves. To understand the characteristic behaviors of hydrogen isotopes in the packed-bed, we carried out breakthrough experiments in a conventional adsorption process and in a practical process following sequential processes alternating between adsorption and desorption. From the former experiments, the results were obtained that the overall mass transfer was influenced by longitudinal dispersion relating to the superficial velocity and that the process governing the mass transfer within adsorbents was diffusion in the macro-pores of pellets. In the latter experiments, unique profile breakthrough curves were observed. These curves can be described with the numerical simulation assuming the initial distributions in a packed-bed. (authors)

  16. Analysis of variation in calibration curves for Kodak XV radiographic film using model-based parameters.

    PubMed

    Hsu, Shu-Hui; Kulasekere, Ravi; Roberson, Peter L

    2010-01-01

    Film calibration is time-consuming work when dose accuracy is essential while working in a range of photon scatter environments. This study uses the single-target single-hit model of film response to fit the calibration curves as a function of calibration method, processor condition, field size and depth. Kodak XV film was irradiated perpendicular to the beam axis in a solid water phantom. Standard calibration films (one dose point per film) were irradiated at 90 cm source-to-surface distance (SSD) for various doses (16-128 cGy), depths (0.2, 0.5, 1.5, 5, 10 cm) and field sizes (5 × 5, 10 × 10 and 20 × 20 cm²). The 8-field calibration method (eight dose points per film) was used as a reference for each experiment, taken at 95 cm SSD and 5 cm depth. The delivered doses were measured using an Attix parallel plate chamber for improved accuracy of dose estimation in the buildup region. Three fitting methods with one to three dose points per calibration curve were investigated for the field sizes of 5 × 5, 10 × 10 and 20 × 20 cm². The inter-day variation of model parameters (background, saturation and slope) were 1.8%, 5.7%, and 7.7% (1 ?) using the 8-field method. The saturation parameter ratio of standard to 8-field curves was 1.083 ± 0.005. The slope parameter ratio of standard to 8-field curves ranged from 0.99 to 1.05, depending on field size and depth. The slope parameter ratio decreases with increasing depth below 0.5 cm for the three field sizes. It increases with increasing depths above 0.5 cm. A calibration curve with one to three dose points fitted with the model is possible with 2% accuracy in film dosimetry for various irradiation conditions. The proposed fitting methods may reduce workload while providing energy dependence correction in radiographic film dosimetry. This study is limited to radiographic XV film with a Lumisys scanner. PMID:21081874

  17. AN ANALYSIS OF THE SHAPES OF INTERSTELLAR EXTINCTION CURVES. VI. THE NEAR-IR EXTINCTION LAW

    SciTech Connect

    Fitzpatrick, E. L. [Department of Astronomy and Astrophysics, Villanova University, 800 Lancaster Avenue, Villanova, PA 19085 (United States); Massa, D. [SGT, Inc., Space Telescope Science Institute, 3700 San Martin Dr., Baltimore, MD 21218 (United States)], E-mail: edward.fitzpatrick@villanova.edu, E-mail: massa@derckmassa.net

    2009-07-10

    We combine new observations from the Hubble Space Telescope's Advanced Camera of Survey with existing data to investigate the wavelength dependence of near-IR (NIR) extinction. Previous studies suggest a power law form for NIR extinction, with a 'universal' value of the exponent, although some recent observations indicate that significant sight line-to-sight line variability may exist. We show that a power-law model for the NIR extinction provides an excellent fit to most extinction curves, but that the value of the power, {beta}, varies significantly from sight line to sight line. Therefore, it seems that a 'universal NIR extinction law' is not possible. Instead, we find that as {beta} decreases, R(V) {identical_to} A(V)/E(B - V) tends to increase, suggesting that NIR extinction curves which have been considered 'peculiar' may, in fact, be typical for different R(V) values. We show that the power-law parameters can depend on the wavelength interval used to derive them, with the {beta} increasing as longer wavelengths are included. This result implies that extrapolating power-law fits to determine R(V) is unreliable. To avoid this problem, we adopt a different functional form for NIR extinction. This new form mimics a power law whose exponent increases with wavelength, has only two free parameters, can fit all of our curves over a longer wavelength baseline and to higher precision, and produces R(V) values which are consistent with independent estimates and commonly used methods for estimating R(V). Furthermore, unlike the power-law model, it gives R(V)s that are independent of the wavelength interval used to derive them. It also suggests that the relation R(V) = -1.36 E(K-V)/(E(B-V)) - 0.79 can estimate R(V) to {+-}0.12. Finally, we use model extinction curves to show that our extinction curves are in accord with theoretical expectations, and demonstrate how large samples of observational quantities can provide useful constraints on the grain properties.

  18. The Great Recession's impact on children.

    PubMed

    Oberg, Charles N

    2011-07-01

    Since that first day of the millennium the United States has experienced two recessions. The first recession began in 2001 and lasted for 10 months. The second, now referred to as the Great Recession, began in December of 2007, was approximately 18 months in duration and was followed by a weak and jobless recovery that has persisted into the second decade of this century. This commentary will examine how low-income children have fared in regard to economic security, food insecurity and housing instability as a result of the Great Recession and recent economic downturn. It concludes with a call to action for a renewed investment in our children through a Children's Recovery and Stimulus Initiative. PMID:21528399

  19. Parametric Curves parametric curves (Splines)

    E-print Network

    Treuille, Adrien

    curves (Splines) · polygonal meshes #12;2 Roller coaster · Next programming assignment involves creating a 3D roller coaster animation · We must model the 3D curve describing the roller coaster, but how

  20. Zirconium determination by cooling curve analysis during the pyroprocessing of used nuclear fuel

    NASA Astrophysics Data System (ADS)

    Westphal, B. R.; Price, J. C.; Bateman, K. J.; Marsden, K. C.

    2015-02-01

    An alternative method to sampling and chemical analyses has been developed to monitor the concentration of zirconium in real-time during the casting of uranium products from the pyroprocessing of used nuclear fuel. The method utilizes the solidification characteristics of the uranium products to determine zirconium levels based on standard cooling curve analyses and established binary phase diagram data. Numerous uranium products have been analyzed for their zirconium content and compared against measured zirconium data. From this data, the following equation was derived for the zirconium content of uranium products:

  1. Buckling Analysis of Anisotropic Curved Panels and Shells with Variable Curvature

    NASA Technical Reports Server (NTRS)

    Jaunky, Navin; Knight, Norman F., Jr.; Ambur, Damodar R.

    1998-01-01

    A buckling formulation for anisotropic curved panels with variable curvature is presented in this paper. The variable curvature panel is assumed to consists of two or more panels of constant but different curvatures. Bezier functions are used as Ritz functions Displacement (C(sup 0)), and slope (C(sup 1)) continuities between segments are imposed by manipulation of the Bezier control points. A first-order shear-deformation theory is used in the buckling formulation. Results obtained from the present formulation are compared with those from finite element simulations and are found to be in good agreement.

  2. The Application of the Principal Curve Analysis Technique to Smooth Beam Lines

    SciTech Connect

    Friedsam, H.; Oren, W.; /SLAC

    2005-08-12

    The smoothness of a beam line refers to the quality of the relative positioning of a number of adjacent beam guiding components. The fact that smoothness is of highest priority when positioning magnets can be seen in the local tolerances imposed by the beam optics. In the past, smoothing has been done by separating horizontal and vertical misalignments and then applying some sort of analytical or manual ''feathering'' technique. The Stanford Linear Collider (SLC) did not easily lend itself to this sort of smoothing because of the highly coupled nature of its pitched and rolled beam line. This paper will discuss an attempt to develop a repeatable method which is independent of the inconsistencies of human judgment and can simultaneously smooth in two or more dimensions. Four major goals were defined for the smoothing algorithm used on the SLC alignment. The first, was to simultaneously model errors for both horizontal and vertical directions. Secondly, a smooth curve whose shape was suggested by the data and not by a predetermined model was implied by the fact that unknown systematic errors were being eliminated. Thirdly, this curve must be a reproducibly fit, independent of the inconsistent nature of human judgment. Fourth, the result of the procedure was to minimize the number and size of magnet movements to reach the final alignment criteria.

  3. Quantum Curves

    NASA Astrophysics Data System (ADS)

    Schwarz, Albert

    2015-02-01

    One says that a pair (P, Q) of ordinary differential operators specify a quantum curve if {[P,Q]=hbar} . If a pair of difference operators (K, L) obey the relation KL = q LK, where {q =e^{hbar}} , we say that they specify a discrete quantum curve. This terminology is prompted by well known results about commuting differential and difference operators, relating pairs of such operators with pairs of meromorphic functions on algebraic curves obeying some conditions. The goal of this paper is to study the moduli spaces of quantum curves. We will relate the moduli spaces for different {hbar} . We will show how to quantize a pair of commuting differential or difference operators (i.e., to construct the corresponding quantum curve or discrete quantum curve).

  4. How many loci on the X-chromosome of Drosophila melanogaster can mutate to recessive lethals

    SciTech Connect

    Abrahamson, S. (Univ. of Wisconsin, Madison); Wuergler, F.E.; DeJongh, C.; Meyer, H.U.

    1980-01-01

    The sensitivity of the sex-linked recessive lethal test is due to the fact that a very large number of loci are included in the mutation study. From extensive studies on the spontaneous sex-linked recessive lethal frequency and spontaneous specific locus mutation rates, it is possible to derive an estimate of the number of loci included in the recessive lethal test. The average number derived from three estimates on male and female germ cells in 563 loci. A second independent approach derives from published data which analyzed short regions of the genome and the proportion of loci within these regions which mutate to lethality. This analysis suggests that 830 loci are potentially lethal mutables. We describe the reasons for concluding that 600 to 800 loci of the approximately 1000 loci on the X-chromosome are involved in the X-linked recessive lethal test.

  5. Propagation of a long wave in a curved duct (I) basic analysis of long wave propagation in a curved duct with variable cross section

    Microsoft Academic Search

    Gu Sheng-shi; Fang Guang-xiong

    1983-01-01

    The propagation of a long wave in a three-dimensional curved duct with variable cross section is studied in this paper. It is shown that a three-dimensional Helmholtz equation can be decomposed into a two-dimensional Laplace (or Poisson) equation and a one-dimensional Webster equation by the curvilinear orthogonal coordinate system, non-dimensionization of reduced wave equation and regular perturbation with small parameterka,

  6. DSA Analysis of IRM Curves for Hydrocarbon Microseepage Characterization in Oil Fields From Eastern and Western Venezuela

    NASA Astrophysics Data System (ADS)

    Aldana, M.; Costanzo-Alvarez, V.; Gonzalez, C.; Gomez, L.

    2009-05-01

    During the last few years we have performed surface reservoir characterization at some Venezuelan oil fields using rock magnetic properties. We have tried to identify, at shallow levels, the "oil magnetic signature" of subjacent reservoirs. Recent data obtained from eastern Venezuela (San Juan field) emphasizes the differences between rock magnetic data from eastern and western oil fields. These results support the hypothesis of different authigenic processes. To better characterize hydrocarbon microseepage in both cases, we apply a new method to analyze IRM curves in order to find out the main magnetic phases responsible for the observed magnetic susceptibility (MS) anomalies. This alternative method is based on a Direct Signal Analysis (DSA) of the IRM in order to identify the number and type of magnetic components. According to this method, the IRM curve is decomposed as the sum of N elementary curves (modeled using the expression proposed by Robertson and France, 1994) whose mean coercivities vary in the interval of the measured magnetic field. The result is an adjusted spectral histogram from which the number of main contributions, their widths and mean coercivities, associated with the number and type of magnetic minerals, can be obtained. This analysis indicates that in western fields the main magnetic mineralogy is magnetite. Conversely in eastern fields, the MS anomalies are mainly caused by the presence of Fe sulphides (i.e. greigite). These results support the hypothesis of two different processes. In western fields a net electron transfer from the organic matter, degraded by hydrocarbon gas leakage, should occur precipitating Fe(II) magnetic minerals (e.g. magnetite). On the other hand, high concentrations of H2S at shallow depth levels, might allow the formation of secondary Fe-sulphides in eastern fields.

  7. A Transit Timing Analysis of Nine Rise Light Curves of the Exoplanet System TrES-3

    NASA Astrophysics Data System (ADS)

    Gibson, N. P.; Pollacco, D.; Simpson, E. K.; Barros, S.; Joshi, Y. C.; Todd, I.; Keenan, F. P.; Skillen, I.; Benn, C.; Christian, D.; Hrudková, M.; Steele, I. A.

    2009-08-01

    We present nine newly observed transits of TrES-3, taken as part of a transit timing program using the RISE instrument on the Liverpool Telescope. A Markov-Chain Monte Carlo analysis was used to determine the planet-star radius ratio and inclination of the system, which were found to be Rp /R sstarf = 0.1664+0.0011 -0.0018 and i = 81.73+0.13 -0.04, respectively, consistent with previous results. The central transit times and uncertainties were also calculated, using a residual-permutation algorithm as an independent check on the errors. A re-analysis of eight previously published TrES-3 light curves was conducted to determine the transit times and uncertainties using consistent techniques. Whilst the transit times were not found to be in agreement with a linear ephemeris, giving ?2 = 35.07 for 15 degrees of freedom, we interpret this to be the result of systematics in the light curves rather than a real transit timing variation. This is because the light curves that show the largest deviation from a constant period either have relatively little out-of-transit coverage or have clear systematics. A new ephemeris was calculated using the transit times and was found to be Tc (0) = 2454632.62610 ± 0.00006 HJD and P = 1.3061864 ± 0.0000005 days. The transit times were then used to place upper mass limits as a function of the period ratio of a potential perturbing planet, showing that our data are sufficiently sensitive to have probed sub-Earth mass planets in both interior and exterior 2:1 resonances, assuming that the additional planet is in an initially circular orbit.

  8. A TRANSIT TIMING ANALYSIS OF NINE RISE LIGHT CURVES OF THE EXOPLANET SYSTEM TrES-3

    SciTech Connect

    Gibson, N. P.; Pollacco, D.; Simpson, E. K.; Barros, S.; Joshi, Y. C.; Todd, I.; Keenan, F. P. [Astrophysics Research Centre, School of Mathematics and Physics, Queen's University, University Road, Belfast, BT7 1NN (United Kingdom); Skillen, I.; Benn, C. [Isaac Newton Group of Telescopes, Apartado de Correos 321, E-38700 Santa Cruz de la Palma, Tenerife (Spain); Christian, D. [Physics and Astronomy Department, California State University Northridge, Northridge, California 91330-8268 (United States); Hrudkova, M. [Astronomical Institute, Charles University Prague, V Holesovickach 2, CZ-180 00 Praha (Czech Republic); Steele, I. A. [Astrophysics Research Institute, Liverpool John Moores University, CH61 4UA (United Kingdom)], E-mail: ngibson07@qub.ac.uk

    2009-08-01

    We present nine newly observed transits of TrES-3, taken as part of a transit timing program using the RISE instrument on the Liverpool Telescope. A Markov-Chain Monte Carlo analysis was used to determine the planet-star radius ratio and inclination of the system, which were found to be R{sub p} /R {sub *} = 0.1664{sup +0.0011} {sub -0.0018} and i = 81.73{sup +0.13} {sub -0.04}, respectively, consistent with previous results. The central transit times and uncertainties were also calculated, using a residual-permutation algorithm as an independent check on the errors. A re-analysis of eight previously published TrES-3 light curves was conducted to determine the transit times and uncertainties using consistent techniques. Whilst the transit times were not found to be in agreement with a linear ephemeris, giving {chi}{sup 2} = 35.07 for 15 degrees of freedom, we interpret this to be the result of systematics in the light curves rather than a real transit timing variation. This is because the light curves that show the largest deviation from a constant period either have relatively little out-of-transit coverage or have clear systematics. A new ephemeris was calculated using the transit times and was found to be T{sub c} (0) = 2454632.62610 {+-} 0.00006 HJD and P = 1.3061864 {+-} 0.0000005 days. The transit times were then used to place upper mass limits as a function of the period ratio of a potential perturbing planet, showing that our data are sufficiently sensitive to have probed sub-Earth mass planets in both interior and exterior 2:1 resonances, assuming that the additional planet is in an initially circular orbit.

  9. A novel technique for inferior rectus recession

    PubMed Central

    Gokyigit, Birsen; Akar, Serpil; Yilmaz, Omer Faruk

    2014-01-01

    Purpose To introduce a novel technique of inferior rectus recession operation to allow larger amounts of recession without causing lower lid retraction and to compare this method with the results obtained in standard inferior rectus recession. Material and methods This study included 20 patients operated on in the authors’ clinic. The median age of the patients was 24.5±18.6 (4–73) years and the median follow-up was 9.3±11.8 (3–43) months. Ten patients operated on with the standard method were labeled Group 1 and ten patients operated on with the new method were labeled Group 2. Without exceeding 4 mm, inferior rectus recession to the whole muscle was performed in Group 1 patients. Inferior rectus recession was also performed on patients in Group 2 following the new method. Using a spatula, approximately 10% of the muscle surface fibers were detached intact as a thin layer, and the remaining 90% of deeper fibers were recessed 4–8 mm as planned. Patients’ preoperative deviations and lower lid positions were recorded. The same parameters were checked in the first and third month postoperatively. Both groups were evaluated retrospectively by screening their files, and the Mann–Whitney U test was used for statistical evaluation. Results Lower lid retraction was seen in four patients of Group 1. There was no retraction in Group 2. While there was a need to perform additional vertical muscle procedures for vertical deviations and lower lid retractions in Group 1, it was observed that there was no need for additional procedures in Group 2 patients. There was a statistically meaningful difference between the two procedures (P<0.05). Conclusion This novel technique was found to be an effective surgical method for permitting more recession without the risk of lower lid retraction. PMID:24492531

  10. Zirconium Determination by Cooling Curve Analysis during the Pyroprocessing of Used Nuclear Fuel

    SciTech Connect

    B.R. Westphal; J.C. Price; K.J. Bateman; K.C. Marsden

    2001-03-01

    An alternative method to sampling and chemical analyses has been developed to monitor the concentration of zirconium in real-time during the casting of uranium products from the pyroprocessing of used nuclear fuel. The method utilizes the solidification characteristics of the uranium products to determine zirconium levels based on standard cooling curve analyses and established binary phase diagram data. Numerous uranium products have been analyzed for their zirconium content and compared against measured zirconium data. From this data, a relationship was derived that incorporates the mass dependency of the uranium products since solidification monitoring is performed external to the melt. Using the relationship, a reasonable fit of calculated to measured zirconium content was established considering the errors in the system.

  11. Feasibility analysis on integration of luminous environment measuring and design based on exposure curve calibration

    NASA Astrophysics Data System (ADS)

    Zou, Yuan; Shen, Tianxing

    2013-03-01

    Besides illumination calculating during architecture and luminous environment design, to provide more varieties of photometric data, the paper presents combining relation between luminous environment design and SM light environment measuring system, which contains a set of experiment devices including light information collecting and processing modules, and can offer us various types of photometric data. During the research process, we introduced a simulation method for calibration, which mainly includes rebuilding experiment scenes in 3ds Max Design, calibrating this computer aid design software in simulated environment under conditions of various typical light sources, and fitting the exposure curves of rendered images. As analytical research went on, the operation sequence and points for attention during the simulated calibration were concluded, connections between Mental Ray renderer and SM light environment measuring system were established as well. From the paper, valuable reference conception for coordination between luminous environment design and SM light environment measuring system was pointed out.

  12. Quantifying differences in the epidemic curves from three influenza surveillance systems: a nonlinear regression analysis.

    PubMed

    Thomas, E G; McCAW, J M; Kelly, H A; Grant, K A; McVERNON, J

    2015-01-01

    Influenza surveillance enables systematic collection of data on spatially and demographically heterogeneous epidemics. Different data collection mechanisms record different aspects of the underlying epidemic with varying bias and noise. We aimed to characterize key differences in weekly incidence data from three influenza surveillance systems in Melbourne, Australia, from 2009 to 2012: laboratory-confirmed influenza notified to the Victorian Department of Health, influenza-like illness (ILI) reported through the Victorian General Practice Sentinel Surveillance scheme, and ILI cases presenting to the Melbourne Medical Deputising Service. Using nonlinear regression, we found that after adjusting for the effects of geographical region and age group, characteristics of the epidemic curve (including season length, timing of peak incidence and constant baseline activity) varied across the systems. We conclude that unmeasured factors endogenous to each surveillance system cause differences in the disease patterns recorded. Future research, particularly data synthesis studies, could benefit from accounting for these differences. PMID:24759447

  13. Modal analysis using a Fourier analyzer, curve-fitting, and modal tuning

    NASA Technical Reports Server (NTRS)

    Craig, R. R., Jr.; Chung, Y. T.

    1981-01-01

    The proposed modal test program differs from single-input methods in that preliminary data may be acquired using multiple inputs, and modal tuning procedures may be employed to define closely spaced frquency modes more accurately or to make use of frequency response functions (FRF's) which are based on several input locations. In some respects the proposed modal test proram resembles earlier sine-sweep and sine-dwell testing in that broadband FRF's are acquired using several input locations, and tuning is employed to refine the modal parameter estimates. The major tasks performed in the proposed modal test program are outlined. Data acquisition and FFT processing, curve fitting, and modal tuning phases are described and examples are given to illustrate and evaluate them.

  14. Evaluation of pollutant loads from stormwater BMPs to receiving water using load frequency curves with uncertainty analysis.

    PubMed

    Park, Daeryong; Roesner, Larry A

    2012-12-15

    This study examined pollutant loads released to receiving water from a typical urban watershed in the Los Angeles (LA) Basin of California by applying a best management practice (BMP) performance model that includes uncertainty. This BMP performance model uses the k-C model and incorporates uncertainty analysis and the first-order second-moment (FOSM) method to assess the effectiveness of BMPs for removing stormwater pollutants. Uncertainties were considered for the influent event mean concentration (EMC) and the aerial removal rate constant of the k-C model. The storage treatment overflow and runoff model (STORM) was used to simulate the flow volume from watershed, the bypass flow volume and the flow volume that passes through the BMP. Detention basins and total suspended solids (TSS) were chosen as representatives of stormwater BMP and pollutant, respectively. This paper applies load frequency curves (LFCs), which replace the exceedance percentage with an exceedance frequency as an alternative to load duration curves (LDCs), to evaluate the effectiveness of BMPs. An evaluation method based on uncertainty analysis is suggested because it applies a water quality standard exceedance based on frequency and magnitude. As a result, the incorporation of uncertainty in the estimates of pollutant loads can assist stormwater managers in determining the degree of total daily maximum load (TMDL) compliance that could be expected from a given BMP in a watershed. PMID:22578429

  15. Parameter sensitivity analysis of the mixed Green-Ampt/Curve-Number method for rainfall excess estimation in small ungauged catchments

    NASA Astrophysics Data System (ADS)

    Romano, N.; Petroselli, A.; Grimaldi, S.

    2012-04-01

    With the aim of combining the practical advantages of the Soil Conservation Service - Curve Number (SCS-CN) method and Green-Ampt (GA) infiltration model, we have developed a mixed procedure, which is referred to as CN4GA (Curve Number for Green-Ampt). The basic concept is that, for a given storm, the computed SCS-CN total net rainfall amount is used to calibrate the soil hydraulic conductivity parameter of the Green-Ampt model so as to distribute in time the information provided by the SCS-CN method. In a previous contribution, the proposed mixed procedure was evaluated on 100 observed events showing encouraging results. In this study, a sensitivity analysis is carried out to further explore the feasibility of applying the CN4GA tool in small ungauged catchments. The proposed mixed procedure constrains the GA model with boundary and initial conditions so that the GA soil hydraulic parameters are expected to be insensitive toward the net hyetograph peak. To verify and evaluate this behaviour, synthetic design hyetograph and synthetic rainfall time series are selected and used in a Monte Carlo analysis. The results are encouraging and confirm that the parameter variability makes the proposed method an appropriate tool for hydrologic predictions in ungauged catchments. Keywords: SCS-CN method, Green-Ampt method, rainfall excess, ungauged basins, design hydrograph, rainfall-runoff modelling.

  16. High resolution melting curve analysis as a new tool for rapid identification of canine parvovirus type 2 strains.

    PubMed

    Bingga, Gali; Liu, Zhicheng; Zhang, Jianfeng; Zhu, Yujun; Lin, Lifeng; Ding, Shuangyang; Guo, Pengju

    2014-01-01

    A high resolution melting (HRM) curve method was developed to identify canine parvovirus type 2 (CPV-2) strains by nested PCR. Two sets of primers, CPV-426F/426R and CPV-87R/87F, were designed that amplified a 52 bp and 53 bp product from the viral VP2 capsid gene. The region amplified by CPV-426F/426R included the A4062G and T4064A mutations in CPV-2a, CPV-2b and CPV-2c. The region amplified by CPV-87F/87R included the A3045T mutation in the vaccine strains of CPV-2 and CPV-2a, CPV-2b and CPV-2c. Faecal samples were obtained from 30 dogs that were CPV antigen-positive. The DNA was isolated from the faecal samples and PCR-amplified using the two sets of primers, and genotyped by HRM curve analysis. The PCR-HRM assay was able to distinguish single nucleotide polymorphisms between CPV-2a, CPV-2b and CPV-2c using CPV-426F/426R. CPV-2a was distinguished from CPV-2b and CPV-2c by differences in the melting temperature. CPV-2b and CPV-2c could be distinguished based on the shape of the melting curve after generating heteroduplexes using a CPV-2b reference sample. The vaccine strains of CPV-2 were identified using CPV-87F/87R. Conventional methods for genotyping CPV strains are labor intensive, expensive or time consuming; the present PCR-based HRM assay might be an attractive alternative. PMID:25159576

  17. Vibration analysis and structural identification of a curved multi-span viaduct

    NASA Astrophysics Data System (ADS)

    Benedettini, Francesco; Dilena, Michele; Morassi, Antonino

    2015-03-01

    This work continues a line of research aimed at the development of a dynamically based monitoring program of bridges in the area of Friuli Venezia Giulia, Italy. The main infrastructure of the survey program is the curved 15-span post-tensioned concrete viaduct considered in this paper. The viaduct consists of three continuous girders separated by expansion joints and supported on piers by means of elastomeric seismic isolators. Output-only vibration tests under traffic loads were carried out to extract the dynamic parameters of the first vibration modes of the structure. The experimental characteristics were compared with those predicted by a preliminary finite-element model. The properties of vibration modes with prevailing amplitudes along the radial and circumferential direction of the viaduct were described with poor precision. This disagreement required the calibration of the finite-element model through a tuning procedure based on modal data. In particular, the experience has shown that the dynamic behavior of the viaduct is strongly influenced by the mechanical properties of the bearing devices supporting the deck superstructures. The calibrated finite-element model can be used as a baseline model for future monitoring and condition assessment programs on this typology of infrastructures.

  18. Analysis of the Validity of Environmental Kuznets Curve for the Baltic States

    NASA Astrophysics Data System (ADS)

    Lapinskien?, Giedr?; Tvaronavi?ien?, Manuela; Vaitkus, Pranas

    2013-12-01

    The paper analyses a traditional Environmental Kuznets Curve (EKC) relationship between greenhouse gases (GHG) and gross domestic product (GDP), extending the research to include some additional factors, such as environmental tax, research and development expenditure, implicit tax rate on energy, primary production of coal and lignite, energy intensity of the economy taken from the Eurostat database. The EKC indicates that, at the early stages of economic growth, pollution increases with the growing use of resources, but when a certain level of income per capita is reached, the trend reverses so that, at a higher development stage, further economic growth leads to the improvement of the environment. In the first part of the research, the validity of the reduced EKC for the Baltic region for the period 1995-2008 is determined. In the second part, the impact of selected factors is statistically tested. In both cases, the standard cubic equation is used because it is believed that this model is the most accurate for the development stage of this region. The research results may be useful for climate change policy design.

  19. Vertically stratified two-phase flow in a curved channel: Insights from a domain perturbation analysis

    SciTech Connect

    Garg, P. [Department of Chemical Engineering, Indian Institute of Technology Roorkee, Roorkee 247 667 (India); Picardo, J. R.; Pushpavanam, S., E-mail: spush@iitm.ac.in [Department of Chemical Engineering, Indian Institute of Technology Madras, Chennai 600 036 (India)

    2014-07-15

    In this work, we investigate the fully developed flow field of two vertically stratified fluids (one phase flowing above the other) in a curved channel of rectangular cross section. The domain perturbation technique is applied to obtain an analytical solution in the asymptotic limit of low Reynolds numbers and small curvature ratios (the ratio of the width of the channel to its radius of curvature). The accuracy of this solution is verified by comparison with numerical simulations of the nonlinear equations. The flow is characterized by helical vortices within each fluid, which are driven by centrifugal forces. The number of vortices and their direction of circulation varies with the parameters of the system (the volume fraction, viscosity ratio, and Reynolds numbers). We identify nine distinct flow patterns and organize the parameter space into corresponding flow regimes. We show that the fully developed interface between the fluids is not horizontal, in general, but is deformed by normal stresses associated with the circulatory flow. The results are especially significant for flows in microchannels, where the Reynolds numbers are small. The mathematical results in this paper include an analytical solution to two coupled biharmonic partial differential equations; these equations arise in two-phase, two-dimensional Stokes flows.

  20. Multivariate curve resolution for the analysis of remotely sensed thermal infrared hyperspectral images.

    SciTech Connect

    Haaland, David Michael; Stork, Christopher Lyle; Keenan, Michael Robert

    2004-07-01

    While hyperspectral imaging systems are increasingly used in remote sensing and offer enhanced scene characterization relative to univariate and multispectral technologies, it has proven difficult in practice to extract all of the useful information from these systems due to overwhelming data volume, confounding atmospheric effects, and the limited a priori knowledge regarding the scene. The need exists for the ability to perform rapid and comprehensive data exploitation of remotely sensed hyperspectral imagery. To address this need, this paper describes the application of a fast and rigorous multivariate curve resolution (MCR) algorithm to remotely sensed thermal infrared hyperspectral images. Employing minimal a priori knowledge, notably non-negativity constraints on the extracted endmember profiles and a constant abundance constraint for the atmospheric upwelling component, it is demonstrated that MCR can successfully compensate thermal infrared hyperspectral images for atmospheric upwelling and, thereby, transmittance effects. We take a semi-synthetic approach to obtaining image data containing gas plumes by adding emission gas signals onto real hyperspectral images. MCR can accurately estimate the relative spectral absorption coefficients and thermal contrast distribution of an ammonia gas plume component added near the minimum detectable quantity.

  1. Stability and dynamic analysis of a slender column with curved longitudinal stiffeners

    NASA Technical Reports Server (NTRS)

    Lake, Mark S.

    1989-01-01

    The results of a stability design study are presented for a slender column with curved longitudinal stiffeners for large space structure applications. Linear stability analyses are performed using a link-plate representation of the stiffeners to determine stiffener local buckling stresses. Results from a set of parametric analyses are used to determine an approximate explicit expression for stiffener local buckling in terms of its geometric parameters. This expression along with other equations governing column stability and mass are assembled into a determinate system describing minimum mass stiffened column design. An iterative solution is determined to solve this system and a computer program incorporating this routine is presented. Example design problems are presented which verify the solution accuracy and illustrate the implementation of the solution routine. Also, observations are made which lead to a greatly simplified first iteration design equation relating the percent increase in column mass to the percent increase in column buckling load. From this, generalizations are drawn as to the mass savings offered by the stiffened column concept. Finally, the percent increase in fundamental column vibration frequency due to the addition of deployable stiffeners is studied.

  2. From principal curves to granular principal curves.

    PubMed

    Zhang, Hongyun; Pedrycz, Witold; Miao, Duoqian; Wei, Zhihua

    2014-06-01

    Principal curves arising as an essential construct in dimensionality reduction and data analysis have recently attracted much attention from theoretical as well as practical perspective. In many real-world situations, however, the efficiency of existing principal curves algorithms is often arguable, in particular when dealing with massive data owing to the associated high computational complexity. A certain drawback of these constructs stems from the fact that in several applications principal curves cannot fully capture some essential problem-oriented facets of the data dealing with width, aspect ratio, width change, etc. Information granulation is a powerful tool supporting processing and interpreting massive data. In this paper, invoking the underlying ideas of information granulation, we propose a granular principal curves approach, regarded as an extension of principal curves algorithms, to improve efficiency and achieve a sound accuracy-efficiency tradeoff. First, large amounts of numerical data are granulated into C intervals-information granules developed with the use of fuzzy C-means clustering and the two criteria of information granulation, which significantly reduce the amount of data to be processed at the later phase of the overall design. Granular principal curves are then constructed by determining the upper and the lower bounds of the interval data. Finally, we develop an objective function using the criteria of information confidence and specificity to evaluate the granular output formed by the principal curves. We also optimize the granular principal curves by adjusting the level of information granularity (the number of clusters), which is realized with the aid of the particle swarm optimization. A number of numeric studies completed for synthetic and real-world datasets provide a useful quantifiable insight into the effectiveness of the proposed algorithm. PMID:23996588

  3. The Periodicity Analysis of the Light Curve of PKS 0735+178 and Implications for its Central Structure

    NASA Astrophysics Data System (ADS)

    Ding, S. X.; Xie, G. Z.; Liang, E. W.; Zhou, S. B.; Ma, L.

    The observation data in the B band for BL Lacerate object PKS 0735+178 during 1970-1998 from twenty two publications have been compiled into a light curve. The light curve shows that PKS 0735+178 is very active and exhibits very complicated non-sinusoidal variations. Using both Jurkevich's method and Power spectrum method to analyze these data we have found two periods of 5.26±0.98 years and 1.24±0.05 years for the outbursts in PKS 0735+178. It is of interest to note that the results of the two methods are the same (almost). In addition, these values are in good agreement with the results found by Smith et al.47 and Webb et al.61 We also apply the binary black hole model to explain the central structure of this object and obtain the masses of the primary and secondary black holes are 1.7×109M? and 2.88×107M? respectively. It should be monitored in future to obtain more data for further analysis to test the hypothesis.

  4. Prediction of preterm and low birth weight delivery by maternal periodontal parameters: receiver operating characteristic (ROC) curve analysis.

    PubMed

    Al Habashneh, Rola; Khader, Yousef S; Jabali, Olfat Al; Alchalabi, Haifa'a

    2013-02-01

    In this study we used receiver-operating characteristic (ROC) analysis to comparatively evaluate maternal periodontal parameters to predict preterm (PB) delivery and low birth weight (LBW) delivery among Jordanian women. A total of 277 pregnant women (20 weeks of gestation or less) had periodontal examination at baseline and followed up until delivery. Gestational age and birth weight were retrieved from their medical records. ROC curve analyses were used to examine the overall discriminatory power of the studied periodontal parameters to predict PB, LBW, and PB or LBW. For the three outcome variables, the area under curve (AUC) ranged from 0.84 to 0.87 for average clinical attachment level (CAL), 0.78-0.86 for percent of sites with CAL ? 5 mm, 0.63-0.74 for percent of sites with CAL ? 6 mm, and 0.71-0.82 for number of missing teeth indicating that they had high discriminating power to predict adverse pregnancy outcomes. All other parameters had AUC less than 0.60 and thus had low discriminating power. Average CAL performed the best in predicting the studied adverse pregnancy outcomes because it has the highest AUC. The severity and extent of periodontal disease as measured by CAL can be used to predict the occurrence of adverse pregnancy outcomes. PMID:22392602

  5. Functional torque ratios and torque curve analysis of shoulder rotations in overhead athletes with and without impingement symptoms.

    PubMed

    Zanca, Gisele G; Oliveira, Ana B; Saccol, Michele F; Ejnisman, Benno; Mattiello-Rosa, Stela M

    2011-12-01

    In this study, we evaluated the peak torque, functional torque ratios, and torque curve profile of the shoulder rotators in overhead athletes with impingement symptoms so as to examine possible alterations in response to sports training and shoulder pain. Twenty-one overhead athletes with impingement symptoms were compared with 25 overhead athletes and 21 non-athletes, none of whom were symptomatic for impingement. The participants performed five maximal isokinetic concentric and eccentric contractions of medial and lateral shoulder rotations at 1.57 rad · s(-1) and 3.14 rad · s(-1). Isokinetic peak torque was used to calculate the eccentric lateral rotation-to-concentric medial rotation and the eccentric medial rotation-to-concentric lateral rotation ratios. An analysis of the torque curve profiles was also carried out. The eccentric lateral rotation-to-concentric medial rotation torque ratio of asymptomatic athletes was lower than that of non-athletes at both test velocities. The concentric medial rotation isokinetic peak torque of the asymptomatic athletes, at 3.14 rad · s(-1), was greater than that of the non-athletes, and the peak appeared to occur earlier in the movement for athletes than non-athletes. These findings suggest that there may be adaptations to shoulder function in response to throwing practice. The eccentric medial rotation-to-concentric lateral rotation torque ratio was altered neither by the practice of university-level overhead sports nor impingement symptoms. PMID:22092229

  6. Glacier recession in Iceland and Austria

    SciTech Connect

    Hall, D.K.; Williams, R.S. Jr.; Bayr, K.J. (NASA, Goddard Space Flight Center, Greenbelt, MD (United States) USGS, Reston, VA (United States) Keene State College, NH (United States))

    1992-03-01

    It has been possible to measure glacier recession on the basis of Landsat data, in conjunction with comparisons of the magnitude of recession of a glacier margin with in situ measurements at fixed points along the same margin. Attention is presently given to the cases of Vatnajokull ice cap, in Iceland, and the Pasterze Glacier, in Austria, on the basis of satellite data from 1973-1987 and 1984-1990, respectively. Indications of a trend toward negative mass balance are noted. Nevertheless, while most of the world's small glaciers have been receding, some are advancing either due to local climate or the tidewater glacier cycle. 21 refs.

  7. Glacier recession in Iceland and Austria

    NASA Technical Reports Server (NTRS)

    Hall, Dorothy K.; Williams, Richard S., Jr.; Bayr, Klaus J.

    1992-01-01

    It has been possible to measure glacier recession on the basis of Landsat data, in conjunction with comparisons of the magnitude of recession of a glacier margin with in situ measurements at fixed points along the same margin. Attention is presently given to the cases of Vatnajokull ice cap, in Iceland, and the Pasterze Glacier, in Austria, on the basis of satellite data from 1973-1987 and 1984-1990, respectively. Indications of a trend toward negative mass balance are noted. Nevertheless, while most of the world's small glaciers have been receding, some are advancing either due to local climate or the tidewater glacier cycle.

  8. Light Curves

    NSDL National Science Digital Library

    2013-02-12

    This is a game about light curves that will test your ability to figure out things about an asteroid from just a graph of its brightness. Astronomers use telescopes to collect light curves - measurements of the brightness of distant asteroids over time. It is part of the Killer Asteroids Web Site. The site also features a background overview of the differences between asteroids and comets, information on different types of asteroids (rubble piles vs monoliths), a discussion of how at risk Earth really is to an asteroid or comet impact, and background information on light curves.

  9. Vibrational spectroscopic image analysis of biological material using multivariate curve resolution-alternating least squares (MCR-ALS).

    PubMed

    Felten, Judith; Hall, Hardy; Jaumot, Joaquim; Tauler, Romà; de Juan, Anna; Gorzsás, András

    2015-02-01

    Raman and Fourier transform IR (FTIR) microspectroscopic images of biological material (tissue sections) contain detailed information about their chemical composition. The challenge lies in identifying changes in chemical composition, as well as locating and assigning these changes to different conditions (pathology, anatomy, environmental or genetic factors). Multivariate data analysis techniques are ideal for decrypting such information from the data. This protocol provides a user-friendly pipeline and graphical user interface (GUI) for data pre-processing and unmixing of pixel spectra into their contributing pure components by multivariate curve resolution-alternating least squares (MCR-ALS) analysis. The analysis considers the full spectral profile in order to identify the chemical compounds and to visualize their distribution across the sample to categorize chemically distinct areas. Results are rapidly achieved (usually <30-60 min per image), and they are easy to interpret and evaluate both in terms of chemistry and biology, making the method generally more powerful than principal component analysis (PCA) or heat maps of single-band intensities. In addition, chemical and biological evaluation of the results by means of reference matching and segmentation maps (based on k-means clustering) is possible. PMID:25569330

  10. Molecular component distribution imaging of living cells by multivariate curve resolution analysis of space-resolved Raman spectra

    NASA Astrophysics Data System (ADS)

    Ando, Masahiro; Hamaguchi, Hiro-o.

    2014-01-01

    Label-free Raman microspectroscopy combined with a multivariate curve resolution (MCR) analysis can be a powerful tool for studying a wide range of biomedical molecular systems. The MCR with the alternating least squares (MCR-ALS) technique, which retrieves the pure component spectra from complicatedly overlapped spectra, has been successfully applied to in vivo and molecular-level analysis of living cells. The principles of the MCR-ALS analysis are reviewed with a model system of titanium oxide crystal polymorphs, followed by two examples of in vivo Raman imaging studies of living yeast cells, fission yeast, and budding yeast. Due to the non-negative matrix factorization algorithm used in the MCR-ALS analysis, the spectral information derived from this technique is just ready for physical and/or chemical interpretations. The corresponding concentration profiles provide the molecular component distribution images (MCDIs) that are vitally important for elucidating life at the molecular level, as stated by Schroedinger in his famous book, "What is life?" Without any a priori knowledge about spectral profiles, time- and space-resolved Raman measurements of a dividing fission yeast cell with the MCR-ALS elucidate the dynamic changes of major cellular components (lipids, proteins, and polysaccharides) during the cell cycle. The MCR-ALS technique also resolves broadly overlapped OH stretch Raman bands of water, clearly indicating the existence of organelle-specific water structures in a living budding yeast cell.

  11. Numerical analysis of anomalous tailing on breakthrough curves during a typical convergent-flow tracer tests

    NASA Astrophysics Data System (ADS)

    Pedretti, D.; Fernandez-Garcia, D.; Sanchez-Vila, X.; Bolster, D.

    2012-12-01

    Breakthrough curves (BTCs) observed during convergent-flow tracer tests (CFTT) usually show non-symmetric shapes. Experimental evidences indicate that the late-time behavior of these BTCs can follow a power-law distributions of the form c=t-m, where the parameter 'm' (the 'BTC slope') range between 1 and 4. While this behavior exist and can be predicted in certain reactive or purely diffusive systems, it also occur when the tracer is conservative and the tests are performed in heterogeneous coarse (e.g. sandy) aquifers. In the latter cases, a quantitative link between the parameters describing geological or hydrodynamic aquifer heterogeneities and the formation and development of power-law BTC tailing has not been found yet. We show here the results of a numerical investigation, by means of which we reproduced flow and conservative transport in unconditional 3D multigaussian fields of log-transformed hydraulic conductivity (Y). We found that, in typical CFTT, BTC tailing may occur due to the stratification of the plume as an effect of the injection mechanisms, which control the arrival times of contaminants to the controlling well. Heterogeneity plays a fundamental role, since it controls the transport connectivity between the injection and the extraction well at each horizon composing the aquifer. When some conditions are fulfilled (highly variability of layer properties, injection distances comparable with the characteristic scale of heterogeneity, and global high Y variance), the power-law slope approaches the unit (m=1), which is also very similar to the travel time scaling of a purely stratified media with log-normal distribution of hydraulic conductivity. For intermediate cases, m varies between 1 and 4. This study suggests that the nature of the memory functions, in coarse aquifers, is an intrinsic characteristic of three-dimensional solute transport, and cannot be reproducible with 2D multigaussian simulations of Y-fields and transport solutions based on the advection-dispersion equation, unless new phenomena are accounted for (such as mass transfer).

  12. A Computer Program for Calculation of Calibration Curves for Quantitative X-Ray Diffraction Analysis.

    ERIC Educational Resources Information Center

    Blanchard, Frank N.

    1980-01-01

    Describes a FORTRAN IV program written to supplement a laboratory exercise dealing with quantitative x-ray diffraction analysis of mixtures of polycrystalline phases in an introductory course in x-ray diffraction. Gives an example of the use of the program and compares calculated and observed calibration data. (Author/GS)

  13. Time-dependent nonlinear analysis of curved nonprismatic prestressed concrete box girder bridges

    Microsoft Academic Search

    In-Ho Jang

    1997-01-01

    The accurate design and analysis of prestressed concrete (PC) bridges during their service life are very important issues. They affect public safety and economy. The behavior of prestressed bridges is complicated, i.e., it includes inelastic response, concrete cracking, steel yielding, creep, shrinkage, temperature, and tendon relaxation phenomena. This study considers the material nonlinearities (concrete, reinforcing mild steel, and prestressing tendon),

  14. New approaches to direct gradient analysis using environmental scalars and statistical curve-fitting procedures

    Microsoft Academic Search

    M. P. Austin; R. B. Cunningham; P. M. Fleming

    1984-01-01

    The conceptual framework of direct gradient analysis (DGA) is discussed in relation to the functional, factorial approach to vegetation. Both approaches use abstract simplified environment gradients with which to correlate vegetation response. Environmental scalars based on physical process models of environment and\\/or known biological growth processes can be incorporated to make analyses less location specific. An example of an environmental

  15. THE XMM-NEWTON /EPIC X-RAY LIGHT CURVE ANALYSIS OF WR 6

    E-print Network

    Ignace, R.

    We obtained four pointings of over 100 ks each of the well-studied Wolf-Rayet star WR 6 with the XMM-Newton satellite. With a first paper emphasizing the results of spectral analysis, this follow-up highlights the X-ray ...

  16. How fast does the Grim Reaper walk? Receiver operating characteristics curve analysis in healthy men aged 70 and over

    PubMed Central

    2011-01-01

    Objective To determine the speed at which the Grim Reaper (or Death) walks. Design Population based prospective study. Setting Older community dwelling men living in Sydney, Australia. Participants 1705 men aged 70 or more participating in CHAMP (Concord Health and Ageing in Men Project). Main outcome measures Walking speed (m/s) and mortality. Receiver operating characteristics curve analysis was used to calculate the area under the curve for walking speed and determine the walking speed of the Grim Reaper. The optimal walking speed was estimated using the Youden index (sensitivity+specificity?1), a common summary measure of the receiver operating characteristics curve, and represents the maximum potential effectiveness of a marker. Results The mean walking speed was 0.88 (range 0.15-1.60) m/s. The highest Youden index (0.293) was observed at a walking speed of 0.82 m/s (2 miles (about 3 km) per hour), corresponding to a sensitivity of 63% and a specificity of 70% for mortality. Survival analysis showed that older men who walked faster than 0.82 m/s were 1.23 times less likely to die (95% confidence interval 1.10 to 1.37) than those who walked slower (P=0.0003). A sensitivity of 1.0 was obtained when a walking speed of 1.36 m/s (3 miles (about 5 km) per hour) or greater was used, indicating that no men with walking speeds of 1.36 m/s or greater had contact with Death. Conclusion The Grim Reaper’s preferred walking speed is 0.82 m/s (2 miles (about 3 km) per hour) under working conditions. As none of the men in the study with walking speeds of 1.36 m/s (3 miles (about 5 km) per hour) or greater had contact with Death, this seems to be the Grim Reaper’s most likely maximum speed; for those wishing to avoid their allotted fate, this would be the advised walking speed. PMID:22174324

  17. Understanding High Recession Rates of Carbon Ablators Seen in Shear Tests in an Arc Jet

    NASA Technical Reports Server (NTRS)

    Driver, David M.; Olson, Michael W.; Barnhardt, Michael D.; MacLean, Matthew

    2010-01-01

    High rates of recession in arc jet shear tests of Phenolic Impregnated Carbon Ablator (PICA) inspired a series of tests and analysis on FiberForm (a carbon preform used in the fabrication of PICA). Arc jet tests were performed on FiberForm in both air and pure nitrogen for stagnation and shear configurations. The nitrogen tests showed little or no recession, while the air tests of FiberForm showed recession rates similar to that of PICA (when adjusted for the difference in density). While mechanical erosion can not be ruled out, this is the first step in doing so. Analysis using a carbon oxidation boundary condition within DPLR was used to predict the recession rate of FiberForm. The analysis indicates that much of the anomalous recession behavior seen in shear tests may simply be an artifact of the non-flight like test configuration (copper upstream of the test article) a result of dissimilar enthalpy and oxygen concentration profiles on the copper. Shape change effects were also investigated and shown to be relatively small.

  18. Nevada, the Great Recession, and Education

    ERIC Educational Resources Information Center

    Verstegen, Deborah A.

    2013-01-01

    The impact of the Great Recession and its aftermath has been devastating in Nevada, especially for public education. This article discusses the budget shortfalls and the impact of the economic crisis in Nevada using case study methodology. It provides a review of documents, including Governor Gibbon's proposals for the public K-12 education system…

  19. Glacier Recession Prepared by Joni L. Kincaid

    E-print Network

    Glacier Recession Prepared by Joni L. Kincaid for the Advancing Geospatial Skills in Science funded by the National Science Foundation's GK-12 Program. Spring, 2007 #12;Glacier: a large mass of ice Line Glacier How do glaciers form? Glaciers form in locations where the snow does not melt over

  20. The effect of recessions on gambling expenditures.

    PubMed

    Horváth, Csilla; Paap, Richard

    2012-12-01

    This article examines the influence of the business cycle on expenditures of three major types of legalized gambling activities: Casino gambling, lottery, and pari-mutuel wagering. Empirical results are obtained using monthly aggregated US per capita consumption time series for the period 1959.01-2010.08. Among the three gambling activities only lottery consumption appears to be recession-proof. This series is characterized by a vast and solid growth that exceeds the growth in income and the growth in other gambling sectors. Casino gambling expenditures show a positive growth during expansions and no growth during recessions. Hence, the loss in income during recessions affects casino gambling. However, income shocks which are not directly related to the business cycle do not influence casino gambling expenditures. Pari-mutuel wagering displays an overall negative trend and its average growth rate is smaller than the growth in income, especially during recessions. The findings of this article provide important implications for the gambling industry and for local governments. PMID:22143980

  1. What Colleges Can Learn from Recessions Past

    ERIC Educational Resources Information Center

    Breneman, David W.

    2008-01-01

    The present financial and credit crisis is unprecedented in recent history, resembling in many ways the onset of the Depression of the 1930s more than subsequent recessions. Presumably, one has learned something about managing such events and will not permit the current economic mess to deteriorate to Depression levels. In this article, the author…

  2. InTube DNA Methylation Profiling by Fluorescence Melting Curve Analysis

    Microsoft Academic Search

    Jesper Worm; Anni Aggerholm; Per Guldberg

    2001-01-01

    Background: Most PCR assays for detection of 5-meth- ylcytosine in genomic DNA entail a two-step procedure, comprising initial PCR amplification and subsequent product analysis in separate operations that usually require manual transfer. These methods generally pro- vide information about methylation of only a few CpG dinucleotides within the target sequence. Methods: An in-tube methylation assay is described that integrates amplification

  3. Acoustic systems containing curved duct sections. [numerical analysis of wave propagation in acoustic ducts

    NASA Technical Reports Server (NTRS)

    Rostafinski, W.

    1975-01-01

    The analysis of waves in bends in acoustical ducting of rectangular cross section was extended to the study of motion near discontinuities. This included determination of the characteristics of the tangential and radial components of the nonpropagating modes. It is established that attenuation of the nonpropagating modes strongly depends on frequency and that, in general, the sharper the bend, the less attenuation may be expected. Evaluation of a bend's impedance and of impedance-generated reflections is also presented in detail.

  4. New light curves and analysis of the short-period Algol XZ Canis Minoris

    NASA Astrophysics Data System (ADS)

    Terrell, Dirk; Gunn, J. B.; Kaiser, Daniel H.

    1994-02-01

    We present new observations of the short-period Algol XZ Canis Minoris made between 25 Dec. 1992 and 1 Mar. 1993. Two new epochs of minimum light were determined and an improved ephemeris is given. Analysis of the observations with the latest version of the Wilson-Devinney program shows that the system is semidetached. Our solution does not indicate the presence of third light, whereas some previously published solutions required large amounts of third light.

  5. Development of Curved-Plate Elements for the Exact Buckling Analysis of Composite Plate Assemblies Including Transverse-Shear Effects

    NASA Technical Reports Server (NTRS)

    McGowan, David M.

    1999-01-01

    The analytical formulation of curved-plate non-linear equilibrium equations including transverse-shear-deformation effects is presented. A unified set of non-linear strains that contains terms from both physical and tensorial strain measures is used. Linearized, perturbed equilibrium equations (stability equations) that describe the response of the plate just after buckling occurs are derived. These equations are then modified to allow the plate reference surface to be located a distance z(sub c) from the centroidal surface. The implementation of the new theory into the VICONOPT exact buckling and vibration analysis and optimum design computer program is described. The terms of the plate stiffness matrix using both classical plate theory (CPT) and first-order shear-deformation plate theory (SDPT) are presented. The effects of in-plane transverse and in-plane shear loads are included in the in-plane stability equations. Numerical results for several example problems with different loading states are presented. Comparisons of analyses using both physical and tensorial strain measures as well as CPT and SDPT are made. The computational effort required by the new analysis is compared to that of the analysis currently in the VICONOPT program. The effects of including terms related to in-plane transverse and in-plane shear loadings in the in-plane stability equations are also examined. Finally, results of a design-optimization study of two different cylindrical shells subject to uniform axial compression are presented.

  6. Recess: an Essential Part of The School Day

    MedlinePLUS

    ... JavaScript. Recess: An Essential Part of the School Day Study shows supervised play boosts teamwork, friendships and ... Recess is an essential part of children's school days that can help set students up for success ...

  7. Genetics Home Reference: Autosomal recessive cerebellar ataxia type 1

    MedlinePLUS

    ... disorder catalog Conditions > Autosomal recessive cerebellar ataxia type 1 (often shortened to ARCA1 ) On this page: Description ... What is ARCA1? Autosomal recessive cerebellar ataxia type 1 (ARCA1) is a condition characterized by progressive problems ...

  8. Instructions for Glacier Recession Lesson Objective: Students will learn

    E-print Network

    Instructions for Glacier Recession Lesson Objective: Students will learn: - about the connection between glaciers and climate, - why glacial studies are important, - how glacier recession affects humanity, and - how humans are affecting glaciers. Materials: Movie ­ Inconvenient Truth For Exercise

  9. Computational analysis of fluorescence induction curves in intact spinach leaves treated at different pH.

    PubMed

    Tongra, Teena; Mehta, Pooja; Mathur, Sonal; Agrawal, Divya; Bharti, Sudhakar; Los, Dmitry A; Allakhverdiev, Suleyman I; Jajoo, Anjana

    2011-02-01

    Effects of change in pH have been investigated on spinach leaf discs by measuring fluorescence induction kinetics using plant efficiency analyzer (PEA). On the basis of computational analysis of the results, we have reported that acidic pH causes a significant inhibition of the donor and the acceptor side of PS II. Energy flux models have been presented using the software Biolyzer HP 3. Effects of pH were investigated on the antenna size heterogeneity of PS II and a relative change in the proportions of ?, ?, and ? centers was observed. PMID:20705115

  10. Recessions lower (some) mortality rates: evidence from Germany.

    PubMed

    Neumayer, Eric

    2004-03-01

    In his article with the provocative title "Are Recessions Good for Your Health?", Ruhm (J. Health Econ. 21(4) (2000) 659) has found robust and consistent evidence that the total mortality rate, age-specific mortality rates as well as most specific mortality causes are pro-cyclical. His finding that high unemployment rates are associated with lower mortality and vice versa stands in stark contrast to Brenner's earlier work, who found the opposite effect, possibly after a time lag. Ruhm controls for state-specific effects in a panel of US states over the period 1972-1991, whereas Brenner's work is based on time-series analysis. Extending and improving upon Ruhm's original analysis, we analyse the effect of state unemployment and economic growth rates on mortality in the states of Germany over the period 1980-2000, both in a static and a dynamic econometric model. Controlling for state-specific effects, we find evidence that aggregate mortality rates for all age groups taken together as well as most specific age groups are lower in recessions. The same is true for mortality from cardiovascular diseases, pneumonia and influenza, motor vehicle accidents and suicides, but not for necessarily for other specific mortality causes. In particular, there is never a statistically significant effect on homicides, other external effects and malignant neoplasms. There are also few differences apparent between the effect on male and female mortality. If we do not control for state-specific effects, then we often arrive at the opposite result with higher unemployment being associated with higher mortality. This suggests that a failure to control for time-invariant state-specific effects leads to omitted variable bias, which would erroneously suggest that mortality rates move counter-cyclically. Overall, we can confirm Ruhm's main finding for another country: recessions lower some, but not all, mortality rates in the case of Germany. PMID:14723900

  11. Automated AFM force curve analysis for determining elastic modulus of biomaterials and biological samples.

    PubMed

    Chang, Yow-Ren; Raghunathan, Vijay Krishna; Garland, Shaun P; Morgan, Joshua T; Russell, Paul; Murphy, Christopher J

    2014-09-01

    The analysis of atomic force microscopy (AFM) force data requires the selection of a contact point (CP) and is often time consuming and subjective due to influence from intermolecular forces and low signal-to-noise ratios (SNR). In this report, we present an automated algorithm for the selection of CPs in AFM force data and the evaluation of elastic moduli. We propose that CP may be algorithmically easier to detect by identifying a linear elastic indentation region of data (high SNR) rather than the contact point itself (low SNR). Utilizing Hertzian mechanics, the data are fitted for the CP. We first detail the algorithm and then evaluate it on sample polymeric and biological materials. As a demonstration of automation, 64 × 64 force maps were analyzed to yield spatially varying topographical and mechanical information of cells. Finally, we compared manually selected CPs to automatically identified CPs and demonstrated that our automated approach is both accurate (< 10nm difference between manual and automatic) and precise for non-interacting polymeric materials. Our data show that the algorithm is useful for analysis of both biomaterials and biological samples. PMID:24951927

  12. BAYESIAN WAVELET-BASED CURVE CLASSIFICATION VIA DISCRIMINANT ANALYSIS WITH MARKOV RANDOM TREE PRIORS

    PubMed Central

    Stingo, Francesco C.; Vannucci, Marina; Downey, Gerard

    2014-01-01

    Discriminant analysis is an effective tool for the classification of experimental units into groups. When the number of variables is much larger than the number of observations it is necessary to include a dimension reduction procedure into the inferential process. Here we present a typical example from chemometrics that deals with the classification of different types of food into species via near infrared spectroscopy. We take a nonparametric approach by modeling the functional predictors via wavelet transforms and then apply discriminant analysis in the wavelet domain. We consider a Bayesian conjugate normal discriminant model, either linear or quadratic, that avoids independence assumptions among the wavelet coefficients. We introduce latent binary indicators for the selection of the discriminatory wavelet coefficients and propose prior formulations that use Markov random tree (MRT) priors to map scale-location connections among wavelets coefficients. We conduct posterior inference via MCMC methods, we show performances on our case study on food authenticity and compare results to several other procedures.. PMID:24761126

  13. Spectral clustering applied for dynamic contrast-enhanced MR analysis of time-intensity curves.

    PubMed

    Tartare, Guillaume; Hamad, Denis; Azahaf, Mustapha; Puech, Philippe; Betrouni, Nacim

    2014-12-01

    Dynamic contrast-enhanced (DCE)-magnetic resonance imaging (MRI) represents an emerging method for the prediction of biomarker responses in cancer. However, DCE images remain difficult to analyze and interpret. Although pharmacokinetic approaches, which involve multi-step processes, can provide a general framework for the interpretation of these data, they are still too complex for robust and accurate implementation. Therefore, statistical data analysis techniques were recently suggested as another valid interpretation strategy for DCE-MRI. In this context, we propose a spectral clustering approach for the analysis of DCE-MRI time-intensity signals. This graph theory-based method allows for the grouping of signals after spatial transformation. Subsequently, these data clusters can be labeled following comparison to arterial signals. Here, we have performed experiments with simulated (i.e., generated via pharmacokinetic modeling) and clinical (i.e., obtained from patients scanned during prostate cancer diagnosis) data sets in order to demonstrate the feasibility and applicability of this kind of unsupervised and non-parametric approach. PMID:25179917

  14. What can we learn from the Fourier analysis of blazar light curves?

    NASA Astrophysics Data System (ADS)

    Finke, Justin

    2015-01-01

    Blazars display strong variability on multiple timescales and in multiple radiation bands. Their variability can be characterized by power spectral densities (PSDs) and time lags as a function of Fourier frequency. We develop a new theoretical model based on analysis of the electron continuity equation carried out in the Fourier domain. This model predicts features in the synchrotron, synchrotron self-Compton (SSC), and external Compton (EC) PSDs and time lags associated with electron cooling, escape, and light travel time effects across the electromagnetic spectrum, from sub-mm to gamma-rays. We also find that FSRQs should have steeper PSD power-law indices than BL Lac objects at low Fourier frequencies if FSRQs produce gamma-rays by EC and BL Lac objects by SSC emission, in qualitative agreement with reported observations by the Fermi Large Area Telescope.

  15. What can we learn from the Fourier analysis of blazar light curves?

    NASA Astrophysics Data System (ADS)

    Finke, Justin; Becker, Peter A.

    2014-08-01

    Blazars display strong variability on multiple timescales and in multiple radiation bands. Their variability can be characterized by power spectral densities (PSDs) and time lags as a function of Fourier frequency. We develop a new theoretical model based on analysis of the electron continuity equation carried out in the Fourier domain. This model predicts features in the synchrotron, synchrotron self-Compton (SSC), and external Compton (EC) PSDs and time lags associated with electron cooling, escape, and light travel time effects across the electromagnetic spectrum, from sub-mm to gamma-rays. We also find that FSRQs should have steeper PSD power-law indices than BL Lac objects at low Fourier frequencies if FSRQs produce gamma-rays by EC and BL Lac objects by SSC emission, in qualitative agreement with reported observations by the Fermi Large Area Telescope.

  16. Cone-beam computed tomography analysis of curved root canals after mechanical preparation with three nickel-titanium rotary instruments.

    PubMed

    Elsherief, Samia M; Zayet, Mohamed K; Hamouda, Ibrahim M

    2013-07-01

    Cone beam computed tomography is a 3-dimensional high resolution imaging method. The purpose of this study was to compare the effects of 3 different NiTi rotary instruments used to prepare curved root canals on the final shape of the curved canals and total amount of root canal transportation by using cone-beam computed tomography. A total of 81 mesial root canals from 42 extracted human mandibular molars, with a curvature ranging from 15 to 45 degrees, were selected. Canals were randomly divided into 3 groups of 27 each. After preparation with Protaper, Revo-S and Hero Shaper, the amount of transportation and centering ability that occurred were assessed by using cone beam computed tomography. Utilizing pre- and post-instrumentation radiographs, straightening of the canal curvatures was determined with a computer image analysis program. Canals were metrically assessed for changes (surface area, changes in curvature and transportation) during canal preparation by using software SimPlant; instrument failures were also recorded. Mean total widths and outer and inner width measurements were determined on each central canal path and differences were statistically analyzed. The results showed that all instruments maintained the original canal curvature well with no significant differences between the different files (P = 0.226). During preparation there was failure of only one file (the protaper group). In conclusion, under the conditions of this study, all instruments maintained the original canal curvature well and were safe to use. Areas of uninstrumented root canal wall were left in all regions using the various systems. PMID:23885273

  17. The 2003 Nov 14 occultation by Titan of TYC 1343-1865-1. II. Analysis of light curves

    E-print Network

    A. Zalucha; A. Fitzsimmons; J. L. Elliot; J. Thomas-Osip; H. B. Hammel; V. S. Dhillon; T. R. Marsh; F. W. Taylor; P. G. J. Irwin

    2007-12-05

    We observed a stellar occultation by Titan on 2003 November 14 from La Palma Observatory using ULTRACAM with three Sloan filters: u', g', and i' (358, 487, and 758 nm, respectively). The occultation probed latitudes 2 degrees S and 1 degrees N during immersion and emersion, respectively. A prominent central flash was present in only the i' filter, indicating wavelength-dependent atmospheric extinction. We inverted the light curves to obtain six lower-limit temperature profiles between 335 and 485 km (0.04 and 0.003 mb) altitude. The i' profiles agreed with the temperature measured by the Huygens Atmospheric Structure Instrument [Fulchignoni, M. et al., 2005. Nature 438, 785-791] above 415 km (0.01 mb). The profiles obtained from different wavelength filters systematically diverge as altitude decreases, which implies significant extinction in the light curves. Applying an extinction model [Elliot, J.L., Young, L.A., 1992. Astron. J. 103, 991-1015] gave the altitudes of line of sight optical depth equal to unity: 396 +/- 7 km and 401 +/- 20 km (u' immersion and emersion); 354 +/- 7 km and 387 +/- 7 km (g' immersion and emersion); and 336 +/- 5 km and 318 +/- 4 km (i' immersion and emersion). Further analysis showed that the optical depth follows a power law in wavelength with index 1.3 +/- 0.2. We present a new method for determining temperature from scintillation spikes in the occulting body's atmosphere. Temperatures derived with this method are equal to or warmer than those measured by the Huygens Atmospheric Structure Instrument. Using the highly structured, three-peaked central flash, we confirmed the shape of Titan's middle atmosphere using a model originally derived for a previous Titan occultation [Hubbard, W.B. et al., 1993. Astron. Astrophys. 269, 541-563].

  18. LOXL3, encoding lysyl oxidase-like 3, is mutated in a family with autosomal recessive Stickler syndrome.

    PubMed

    Alzahrani, Fatema; Al Hazzaa, Selwa A; Tayeb, Hamsa; Alkuraya, Fowzan S

    2015-04-01

    Stickler syndrome (SS) is a collagenopathy characterized by arthropathy and vitreoretinopathy with high myopia and cleft palate as common features. In a family with an autosomal recessive SS that does not map to genes known to cause autosomal recessive forms of SS, we combined autozygome and exome analysis to identify a novel missense variant in LOXL3 as the likely candidate cause. LOXL3 cross-links collagen II and its morphants phenocopy the craniofacial defects characteristic of collagen XI deficiency. We propose LOXL3 as a novel candidate gene for autosomal recessive SS. PMID:25663169

  19. Lessons Learned from a Comparative Analysis of Surgical Outcomes of and Learning Curves for Laparoscopy-Assisted Distal Gastrectomy

    PubMed Central

    Moon, Jun-Seok; Park, Man Sik; Kim, Jong-Han; Jang, You-Jin; Park, Sung-Soo; Mok, Young-Jae; Kim, Seung-Joo; Kim, Chong-Suk

    2015-01-01

    Purpose Before expanding our indications for laparoscopic gastrectomy to advanced gastric cancer and adopting reduced port laparoscopic gastrectomy, we analyzed and audited the outcomes of laparoscopy-assisted distal gastrectomy (LADG) for adenocarcinoma; this was done during the adoptive period at our institution through the comparative analysis of short-term surgical outcomes and learning curves (LCs) of two surgeons with different careers. Materials and Methods A detailed comparative analysis of the LCs and surgical outcomes was done for the respective first 95 and 111 LADGs performed by two surgeons between July, 2006 and June, 2011. The LCs were fitted by using the non-linear ordinary least squares estimation method. Results The postoperative morbidity and mortality rates were 14.6% and 0.0%, respectively, and there was no significant difference in the morbidity rates (12.6% vs. 16.2%, P=0.467). More than 25 lymph nodes were retrieved by each surgeon during LADG procedures. The LCs of both surgeons were distinct. In this study, a stable plateau of the LC was not achieved by both surgeons even after performing 90 LADGs. Conclusions Regardless of the experience with gastrectomy or laparoscopic surgery for other organs, or the age of surgeon, the outcome was quite acceptable; the learning process differ according to the surgeon's experience and individual characteristics.

  20. Cyclic Fatigue Testing of Three Different Rotary Nickel Titanium Endodontic Instruments in Simulated Curved Canals - An in Vitro Sem Analysis

    PubMed Central

    Reddy Y., Pallavi; S., Kavita; Subbarao, C.V.

    2014-01-01

    Introduction: Instrument separation is a serious concern in endodontics. Stainless steel instruments usually deform before they separate whereas Nickel Titanium instruments do not show any sign of deformation. Aim: of the present study was to compare the cyclic rotations needed to fracture three different rotary nickel titanium endodontic instruments namely Profile, K3 Endo, RaCe in simulated curved canals having 2 different radii of curvature i.e., 5mm &10mm with a constant angle of curvature of 45°. The fractured surfaces were analysed using Scanning Electron Microscopy (SEM). Materials and Methods: Sixty rotary nickel titanium instruments were used for analysis in this study. The instruments were divided into three groups based on the different cross sections. Three groups were further divided into two sub groups based on radius of curvatures. Ten files were tested in each sub-group. Results: Group A (Profile) showed increased number of cycles to failure i.e., low incidence of fracture at both the radii of curvatures when compared to the other two groups. SEM analysis showed that in Group A the fractured surface of the files tested were characterized by the presence of smooth area on their edges associated with nucleation and slow fatigue crack propagation when compared to Group B and C. Therefore Group A (Profile) demonstrated least cyclic fatigue when compared to the other two groups. PMID:24701537

  1. Rapid Detection of Clonal T-Cell Receptor-? Gene Rearrangements in T-Cell Lymphomas Using the LightCycler-Polymerase Chain Reaction with DNA Melting Curve Analysis

    PubMed Central

    Yang, Xiao Yan; Xu, Dongsheng; Du, Juan; Kamino, Hideko; Rakeman, Jennifer; Ratech, Howard

    2005-01-01

    Various molecular methods have been developed to diagnose clonal T-cell receptor (TCR) gene rearrangements in clinical samples. Most polymerase chain reaction strategies for detecting clonal TCR gene rearrangements rely on either gel or capillary electrophoresis. However, a cumbersome manual transfer step separates amplification from analysis. Recently, we developed a novel polymerase chain reaction assay using the LightCycler system to detect clonal immunoglobulin heavy chain gene rearrangement. In the current study, we extend this work to include the TCR. We report that clonal TCR-? (TCR-?) gene rearrangements can be detected in less than 1 hour after preparing the DNA by measuring DNA melting immediately after amplification in a single closed capillary tube. We retrospectively studied 52 fresh-frozen tissue samples from patients clinically suspected of T-cell malignancy. A clonal TCR-? gene rearrangement was detected in 14 samples by DNA melting curve analysis. When DNA melting was compared to the gold standard methods of Southern blot or denaturing gradient gel electrophoresis, it achieved a sensitivity equal to 71% and a specificity equal to 94%. We also compared melting curve analysis and polyacrylamide gel electrophoresis: melting curve analysis reached a sensitivity equal to 100% and a specificity equal to 97%. We conclude that DNA melting curve analysis in the LightCycler system has potential for clinical use as a new, ultra-fast method for the initial diagnosis of clonal TCR-? gene rearrangements. PMID:15681478

  2. Curved Knives

    Microsoft Academic Search

    W. F. Sinclair

    1897-01-01

    IT may interest your correspondent, Dr. Otis T. Mason, to know that the curved ``drawing-knife'' described by him has representatives in Western (British) India. The Kolis (fishing races) of the Bombay coast wore lately, and some still wear, knives made by local blacksmiths, of which the blade, 2 to 3 inches long, was shaped and edged like that of an

  3. Development of Curved-Plate Elements for the Exact Buckling Analysis of Composite Plate Assemblies Including Transverse-Shear Effects

    NASA Technical Reports Server (NTRS)

    McGowan, David Michael

    1997-01-01

    The analytical formulation of curved-plate non-linear equilibrium equations including transverse-shear-deformation effects is presented. The formulation uses the principle of virtual work. A unified set of non-linear strains that contains terms from both physical and tensorial strain measures is used. Linearized, perturbed equilibrium equations (stability equations) that describe the response of the plate just after buckling occurs are then derived after the application of several simplifying assumptions. These equations are then modified to allow the reference surface of the plate to be located at a distance z(sub c) from the centroidal surface. The implementation of the new theory into the VICONOPT exact buckling and vibration analysis and optimum design computer program is described as well. The terms of the plate stiffness matrix using both Classical Plate Theory (CPT) and first-order Shear-Deformation Plate Theory (SDPT) are presented. The necessary steps to include the effects of in-plane transverse and in-plane shear loads in the in-plane stability equations are also outlined. Numerical results are presented using the newly implemented capability. Comparisons of results for several example problems with different loading states are made. Comparisons of analyses using both physical and tensorial strain measures as well as CPT and SDPF are also made. Results comparing the computational effort required by the new analysis to that of the analysis currently in the VICONOPT program are presented. The effects of including terms related to in-plane transverse and in-plane shear loadings in the in-plane stability equations are also examined. Finally, results of a design-optimization study of two different cylindrical shells subject to uniform axial compression are presented.

  4. Recessive mutations in CAKUT and VACTERL association.

    PubMed

    Westland, Rik; Sanna-Cherchi, Simone

    2014-06-01

    Understanding the complex genetic makeup underlying congenital anomalies of the kidney and urinary tract (CAKUT) is of primary importance to improve diagnosis, stratify risk for later-onset complications, and develop therapeutic strategies. Saisawat et al. used homozygosity mapping coupled with next-generation sequencing to identify recessive mutations in TRAP1 in families with isolated CAKUT and with VACTERL association. This study points to a novel player in kidney development, possibly affecting apoptosis and endoplasmic reticulum stress signaling. PMID:24875543

  5. Cutting Symmetrical Recesses In Soft Ceramic Tiles

    NASA Technical Reports Server (NTRS)

    Nesotas, Tony C.; Tyler, Brent

    1989-01-01

    Simple tool cuts hemispherical recesses in soft ceramic tiles. Designed to expose wires of thermocouples embedded in tiles without damaging leads. Creates neat, precise holes around wires. End mill includes axial hole to accommodate thermocouple wires embedded in material to be cut. Wires pass into hole without being bent or broken. Dimensions in inches. Used in place of such tools as dental picks, tweezers, spatulas, and putty knives.

  6. Recovering From Recession - With Far Less Pain

    NSDL National Science Digital Library

    2010-05-04

    Thirty-seventh monthly installment of our "What A Year!" website project, introducing life science breakthroughs to middle and high school students and their teachers. Gum recession is both aesthetically unpleasant and medically risky. At risk are the patient's teeth and oral health. But the traditional treatment has been painful and not completely satisfactory. Now there is a new treatment that works better and reduces pain and discomfort.

  7. Autosomal recessive cutis laxa syndrome revisited

    PubMed Central

    Morava, Éva; Guillard, Maïlys; Lefeber, Dirk J; Wevers, Ron A

    2009-01-01

    The clinical spectrum of the autosomal recessive cutis laxa syndromes is highly heterogeneous with respect to organ involvement and severity. One of the major diagnostic criteria is to detect abnormal elastin fibers. In several other clinically similar autosomal recessive syndromes, however, the classic histological anomalies are absent, and the definite diagnosis remains uncertain. In cutis laxa patients mutations have been demonstrated in elastin or fibulin genes, but in the majority of patients the underlying genetic etiology remains unknown. Recently, we found mutations in the ATP6V0A2 gene in families with autosomal recessive cutis laxa. This genetic defect is associated with abnormal glycosylation leading to a distinct combined disorder of the biosynthesis of N- and O-linked glycans. Interestingly, similar mutations have been found in patients with wrinkly skin syndrome, without the presence of severe skin symptoms of elastin deficiency. These findings suggest that the cutis laxa and wrinkly skin syndromes are phenotypic variants of the same disorder. Interestingly many phenotypically similar patients carry no mutations in the ATP6V0A2 gene. The variable presence of protein glycosylation abnormalities in the diverse clinical forms of the wrinkled skin-cutis laxa syndrome spectrum necessitates revisiting the diagnostic criteria to be able to offer adequate prognosis assessment and counseling. This paper aims at describing the spectrum of clinical features of the various forms of autosomal recessive cutis laxa syndromes. Based on the recently unraveled novel genetic entity we also review the genetic aspects in cutis laxa syndromes including genotype–phenotype correlations and suggest a practical diagnostic approach. PMID:19401719

  8. A new classification system for gingival and palatal recession

    PubMed Central

    Kumar, Ashish; Masamatti, Sujata Surendra

    2013-01-01

    Various classifications have been proposed to classify gingival recession. Miller's classification of gingival recession is most widely followed. With a wide array of cases in daily clinical practice, it is often difficult to classify numerous gingival recession cases according to defined criteria of the present classification systems. To propose a new classification system that gives a comprehensive depiction of recession defect that can be used to include cases that cannot be classified according to present classifications. A separate classification system for palatal recessions (PR) is also proposed. This article outlines the limitations of present classification systems and also the inability to classify PR. A new comprehensive classification system is proposed to classify recession on the basis of the position of interdental papilla and buccal/lingual/palatal recessions. PMID:23869122

  9. Rapid Screening of Topoisomerase Gene Mutations by a Novel Melting Curve Analysis Method for Early Warning of Fluoroquinolone-Resistant Streptococcus pneumoniae Emergence

    Microsoft Academic Search

    Kazuko Y. Fukushima; Yoichi Hirakata; Kazuyuki Sugahara; Katsunori Yanagihara; Akira Kondo; Shigeru Kohno; Shimeru Kamihira

    2006-01-01

    We developed a real-time PCR assay combined with melting curve analysis for rapidly genotyping quinolone resistance-determining regions (QRDR) of topoisomerase genes in Streptococcus pneumoniae. This assay was not only accurate for the screening of fluoroquinolone (FQ) resistance but also relevant as an early warning system for detecting preexisting single QRDR mutations.

  10. ON THE RATIO OF PHOTONS TO ELECTRONS IN EXTENSIVE AIR SHOWERS OF COSMIC RADIATION FOUND FROM ANALYSIS OF THE TRANSITION CURVE

    Microsoft Academic Search

    J. M. Massalski; A. Oles

    1958-01-01

    An analysis is made of the transition curve for particles of extensive ; air showers of cosmic radiation, at an altitude of 2636 m above sea level. The ; existing discrepancy between the experimental photon-to-electron ratio (p\\/e) and ; theory is explained. In accordance with the predictions of the theory a large ; number of photons were found with energies

  11. ON THE RATIO OF PHOTONS TO ELECTRONS IN EXTENSIVE AIR SHOWERS OF COSMIC RADIATION FOUND FROM ANALYSIS OF THE TRANSITION CURVE. Report No. 75\\/VI

    Microsoft Academic Search

    J. M. Massalski; A. Oles

    1959-01-01

    An analysis is made of the transition curve for particles of extensive ; air showers of cosmic radiation, at an altitude of 2636 m above sea level. The ; existing disparity between the experimental photon-to-electron ratio (p\\/e) and ; theory is explained. In accordance with the predictions of the theory a large ; number of photons were found with energies

  12. Periosteoplasty for covering gingival recessions: Clinical results

    PubMed Central

    Virnik, Sascha; Chiari, Friedrich Michael; Gaggl, Alexander

    2009-01-01

    This is a case series in which a new technique for the surgical treatment of periodontal recessions is presented along with the results of the first clinical trial. A new technique of periodontal flap surgery was performed on 30 patients with severe periodontal recessions of the upper or lower front teeth. Root and soft tissue scaling was carried out with an open approach, then the periosteum was incised and mobilized at the apical part of the mucoperiosteum flap to cover the defect before the mucoperiosteum was reattached and fixed by sutures. Sulcus bleeding, periodontal probing depths, attachment loss and the length of the attached gingiva of the affected teeth were recorded preoperatively and at 3, 6, and 12 months postoperatively. Every clinical parameter was improved by surgery. No sulcus bleeding was observed at any time during the postoperative follow-up. A mean reattachment of 5.5 mm was noticed 12 months postoperatively at a mean probing depth of 0.3 mm. The mean height of the attached gingiva was 0 mm before surgery, 2.3 mm at three and six months postoperatively, and 2.2 mm at 12 months. The periosteum eversion technique is suitable for the treatment of gingival recessions resulting in good gingival function and a clear improvement in aesthetics. PMID:23674900

  13. The Great Recession, unemployment and suicide

    PubMed Central

    Norström, Thor; Grönqvist, Hans

    2015-01-01

    Background How have suicide rates responded to the marked increase in unemployment spurred by the Great Recession? Our paper puts this issue into a wider perspective by assessing (1) whether the unemployment-suicide link is modified by the degree of unemployment protection, and (2) whether the effect on suicide of the present crisis differs from the effects of previous economic downturns. Methods We analysed the unemployment-suicide link using time-series data for 30 countries spanning the period 1960–2012. Separate fixed-effects models were estimated for each of five welfare state regimes with different levels of unemployment protection (Eastern, Southern, Anglo-Saxon, Bismarckian and Scandinavian). We included an interaction term to capture the possible excess effect of unemployment during the Great Recession. Results The largest unemployment increases occurred in the welfare state regimes with the least generous unemployment protection. The unemployment effect on male suicides was statistically significant in all welfare regimes, except the Scandinavian one. The effect on female suicides was significant only in the eastern European country group. There was a significant gradient in the effects, being stronger the less generous the unemployment protection. The interaction term capturing the possible excess effect of unemployment during the financial crisis was not significant. Conclusions Our findings suggest that the more generous the unemployment protection the weaker the detrimental impact on suicide of the increasing unemployment during the Great Recession. PMID:25339416

  14. Embrasure morphology and central papilla recession

    PubMed Central

    Saxena, Divya; Kapoor, Anoop; Malhotra, Ranjan; Grover, Vishakha

    2014-01-01

    Background: The aim of this study was to ascertain the effects of vertical and horizontal distances between the maxillary central incisors on the presence of interproximal dental papilla and to assess the association between the embrasure morphology and central papilla recession. Materials and Methods: The central papilla was visually assessed in 50 subjects using the standardized periapical radiographs of maxillary central incisors. The following vertical distances were measured; distance from the contact point to papilla tip, CP to proximal cementoenamel (pCEJ) junction, bone crest to CP (BC-CP) and BC-PT. The horizontal distance measured was interdental width (IDW) at pCEJ level. The measurements were recorded using a digital electronic caliper. Results: Significant association between the embrasure morphology and central papilla recession was observed for all study groups. All the interdental variables were significantly related to the presence of interdental papillae, with BC-CP distance being the strongest determinant of central papilla presence. The percentage of interdental papilla presence was 100% when the BC-CP distance was ?6 mm and IDW ranged between 0.5 and 1.5 mm. Central papilla recession was observed most frequently with wide-long and narrow-long embrasure morphology. Conclusion: In relation to maxillary central incisors, all the interdental variables have significant influences on the presence of interdental papillae, with distance from BC to CP being the strongest determinant of central papilla presence. PMID:24872628

  15. Maternal uniparental isodisomy causing autosomal recessive GM1 gangliosidosis: a clinical report.

    PubMed

    King, Jessica E; Dexter, Amy; Gadi, Inder; Zvereff, Val; Martin, Meaghan; Bloom, Miriam; Vanderver, Adeline; Pizzino, Amy; Schmidt, Johanna L

    2014-10-01

    Uniparental disomy is a genetic cause of disease that may result in the inheritance of an autosomal recessive condition. A child with developmental delay and hypotonia was seen and found to have severely abnormal myelination. Lysosomal enzyme testing identified an isolated deficiency of beta-galactosidase. Subsequently, homozygous missense mutations in the galactosidase, beta 1 (GLB1) gene on chromosome 3 were found. Parental testing confirmed inheritance of two copies of the same mutated maternal GLB1 gene, and no paternal copy. SNP analysis was also done to confirm paternity. The patient was ultimately diagnosed with autosomal recessive GM1 gangliosidosis caused by maternal uniparental isodisomy. We provide a review of this patient and others in which uniparental disomy (UPD) of a non-imprinted chromosome unexpectedly caused an autosomal recessive condition. This is the first case of GM1 gangliosidosis reported in the literature to have been caused by UPD. It is important for genetic counselors and other health care providers to be aware of the possibility of autosomal recessive disease caused by UPD. UPD as a cause of autosomal recessive disease drastically changes the recurrence risk for families, and discussions surrounding UPD can be complex. Working with families to understand UPD when it occurs requires a secure and trusting counselor-family relationship. PMID:24777551

  16. Mutations of the tyrosinase gene produce autosomal recessive ocular albinism

    SciTech Connect

    King, R.A.; Summers, C.G.; Oetting, W.S. [Univ. of Minnesota, Minneapolis, MN (United States)] [and others

    1994-09-01

    Albinism has historically been divided into ocular (OA) and oculocutaneous (OCA) types based on the presence or absence of clinically apparent skin and hair involvement in an individual with the ocular features of albinism. The major genes for OCA include the tyrosinase gene in OCA1 and the P gene in OCA2. X-linked and autosomal recessive OA have been described and the responsible genes have not been identified. We now present six Caucasian individuals who have the phenotype of autosomal recessive OA but who have OCA1 as shown by the presence of mutations of the tyrosinase. They had white or very light hair and white skin at birth, and cutaneous pigment developed in the first decade of life. At ages ranging from 1.5-23 years, hair color was dark blond to light brown. The skin had generalized pigment and well developed tan was present on the exposed arm and face skin of four. Iris pigment was present and iris translucency varied. Molecular analysis of the tyrosinase gene, using PCR amplification and direct di-deoxy sequencing showed the following mutations: E398Z/E398Q, P406S/g346a, R402E/T373K, ?/D383N, and H211N/T373K. The homozygous individual was not from a known consanguineous mating. T373K is the most common tyrosinase gene mutation in our laboratory. Three of these mutations are associated with a total loss of tyrosinase activity (g346a splice-site, T373K, and D383N), while four are associated with residual enzyme activity (H211N, R402E, E398Q, and P406S). These studies show that mutations of the tyrosinase gene can produce the phenotype of autosomal recessive OA in an individual who has normal amounts of cutaneous pigment and the ability to tan after birth. This extends the phenotypic range of OCA1 to normal cutaneous pigment after early childhood, and suggest that mutations of the tyrosinase gene account for a significant number of individuals with autosomal recessive OA.

  17. Skin Expression of Metalloproteinases and Tissue Inhibitor of Metalloproteinases in Sibling Patients with Recessive Dystrophic Epidermolysis and Intrafamilial Phenotypic Variation

    Microsoft Academic Search

    Christine Bodemer; Sylvie Igondjo Tchen; Sabah Ghomrasseni; Sylvie Séguier; Frédérick Gaultier; Sylvie Fraitag; Yves de Prost; Gaston Godeau

    2003-01-01

    A number of COL7A1 mutations have now been reported in recessive dystrophic epidermolysis bullosa patients, and the analysis of phenotype?genotype correlations showed evidence for interfamilial and intrafamilial phenotypic variability, occurring for the same mutation. Collagenase and stromelysin activities have been found to be overexpressed in skin cultures of some recessive dystrophic epidermolysis bullosa patients, and tissue destruction in the disease

  18. Latent growth curve analysis of fear during a speech task before and after treatment for social phobia.

    PubMed

    Price, Matthew; Anderson, Page L

    2011-11-01

    Models of social phobia highlight the importance of anticipatory anxiety in the experience of fear during a social situation. Anticipatory anxiety has been shown to be highly correlated with performance anxiety for a variety of social situations. A few studies show that average ratings of anxiety during the anticipation and performance phases of a social situation decline following treatment. Evidence also suggests that the point of confrontation with the feared stimulus is the peak level of fear. No study to date has evaluated the pattern of anxious responding across the anticipation, confrontation, and performance phases before and after treatment, which is the focus of the current study. Socially phobic individuals (N = 51) completed a behavioral avoidance task before and after two types of manualized cognitive behavioral therapy, and gave ratings of fear during the anticipation and performance phases. Results from latent growth curve analysis were the same for the two treatments and suggested that before treatment, anxiety sharply increased during the anticipation phase, was highly elevated at the confrontation, and gradually increased during the performance phase. After treatment, anxiety increased during the anticipation phase, although at a much slower rate than at pretreatment, peaked at confrontation, and declined during the performance phase. The findings suggest that anticipatory experiences are critical to the experience of fear for public speaking and should be incorporated into exposures. PMID:21907972

  19. Simultaneous detection of Listeria monocytogenes and Salmonella spp. in dairy products using real time PCR-melt curve analysis.

    PubMed

    Singh, Jitender; Batish, Virender K; Grover, Sunita

    2012-04-01

    The present investigation reports development of post real time PCR (RTi-PCR) - melt curve analysis for simultaneous detection of Listeria monocytogenes and Salmonella spp. The optimal Sybr Green I (SG-I) concentration of 1.6 ?M resulted in two specific peaks with melting temperature (Tm) of 79.90?±?0.39 °C and 86.29?±?0.13 °C for L. monocytogenes and Salmonella spp respectively. The detection sensitivity of the assay in reconstituted non-fat dried milk (NFDM; 11%) spiked with the target pathogens at different levels was 3 log cfu per ml of each pathogen. However, the sensitivity was improved up to 1 log cfu per ml by including pre-enrichment step of 6 h. On application of assay on 60 market samples, one sample each of raw milk and ice cream was detected positive for L. monocytogenes and Salmonella spp. Assay was quite specific as no cross reactivity with non target cultures could be observed. The developed assay can find valuable application in monitoring dairy products for the presence of L. monocytogenes and Salmonella spp. to ensure their microbiological quality and safety. PMID:23572847

  20. A meta-analysis of education effects on chronic disease: the causal dynamics of the Population Education Transition Curve.

    PubMed

    Smith, William C; Anderson, Emily; Salinas, Daniel; Horvatek, Renata; Baker, David P

    2015-02-01

    As the Epidemiological Transition progresses worldwide, chronic diseases account for the majority of deaths in developed countries and a rising proportion in developing countries indicating a new global pattern of mortality and health challenges into the future. Attainment of formal education is widely reported to have a negative gradient with risk factors and onset of chronic disease, yet there has not been a formal assessment of this research. A random-effects meta-analysis finds that across 414 published effects more education significantly reduces the likelihood of chronic disease, except for neoplastic diseases with substantial genetic causes. Some studies, however, report null effects and other research on infectious disease report positive education gradients. Instead of assuming these contradictory results are spurious, it is suggested that they are part of a predictable systemic interaction between multiple mediating effects of education and the Epidemiological Transition stage of the population; and thus represent one case of the Population Education Transition Curve modeling changes in the association between education and health as dependent on population context. PMID:25459208

  1. Omnipotent Suppressors Effective in ?+ Strains of SACCHAROMYCES CEREVISIAE: Recessiveness and Dominance

    PubMed Central

    Ono, Bun-Ichiro; Moriga, Nozomi; Ishihara, Kiyomi; Ishiguro, Junpei; Ishino, Yumiko; Shinoda, Sumio

    1984-01-01

    We have characterized recessive and dominant omnipotent suppressor mutations obtained by conversion of the leu2-1 UAA mutation and the met8-UAG mutation in a ?+ strain of Saccharomyces cerevisiae. The suppressors that act recessively upon these markers fell into two complementation groups; the sup47 and sup36 suppressors show linkage to the tyr1 locus and the aro1 locus, respectively. Of the suppressors acting dominantly upon both markers, those linked to the tyr1 locus are alleles of the SUP46 ribosomal mutation. The sup47 suppressors differ from the SUP46 suppressors not only in their suppressor activities in heterozygous diploids but also in their map positions relative to the tyr1 locus and their effects on the S11 ribosomal protein. The remaining dominant suppressors are not alleles of sup36 as judged by linkage analysis. The recessive suppressors and the dominant suppressors also differ in their effects on cell growth. PMID:17246215

  2. Citizen Support for Northern Ohio Community College Funding Initiatives during an Economic Recession Recovery

    ERIC Educational Resources Information Center

    Flores, Patricia

    2013-01-01

    The current research, "Citizen Support for Northern Ohio Community College Funding Initiatives during an Economic Recession Recovery", asks the question: Do the citizens of Northern Ohio support community college funding during difficult economic times? Based on the theory of Stakeholder Analysis, the purpose of this concurrent,…

  3. Is the Elimination of Recess in School a Violation of a Child's Basic Human Rights?

    ERIC Educational Resources Information Center

    Dubroc, Alicia M.

    2007-01-01

    The elimination of recess in schools across the country is becoming a normal occurrence in many communities, large and small. In each study presented in this content analysis, we find that free time and unstructured play is indeed essential to a child's healthy cognitive development. Article 31 of the United Nations Convention on the Rights of…

  4. Curved Space or Curved Vacuum?

    E-print Network

    Eric V. Linder

    2005-10-11

    While the simple picture of a spatially flat, matter plus cosmological constant universe fits current observation of the accelerated expansion, strong consideration has also been given to models with dynamical vacuum energy. We examine the tradeoff of ``curving'' the vacuum but retaining spatial flatness, vs. curving space but retaining the cosmological constant. These different breakdowns in the simple picture could readily be distinguished by combined high accuracy supernovae and cosmic microwave background distance measurements. If we allow the uneasy situation of both breakdowns, the curvature can still be measured to 1%, but at the price of degrading estimation of the equation of state time variation by 60% or more, unless additional information (such as weak lensing data or a tight matter density prior) is included.

  5. Assessment of threatened flora susceptibility to Phytophthora cinnamomi by analysis of disease progress curves in shadehouse and natural environments

    Microsoft Academic Search

    B. L. Shearer; C. E. Crane; S. Barrett; A. Cochrane

    2007-01-01

    Disease progress curves were evaluated for the assessment of the susceptibility of the flora of the South-West Botanical Province\\u000a of Western Australia threatened by Phytophthora cinnamomi infection. Disease progress was analysed with the logistic model because this model describes numerous observed disease progress\\u000a curves. In addition, the three logistic model parameters, upper asymptote (Kmax), lag time (t1\\/2K) and intrinsic rate

  6. High-resolution DNA melt-curve analysis for cost-effective mass screening of pairwise species interactions.

    PubMed

    McCarthy, James K; Didham, Raphael K; Brockerhoff, Eckehard G; van Bysterveldt, Katherine A; Varsani, Arvind

    2013-09-01

    Ecological studies of pairwise interactions are constrained by the methods available for rapid species identification of the interacting organisms. The resolution of data required to characterize species interaction networks at multiple spatio-temporal scales can be intensive, and therefore laborious and costly to collect. We explore the utility of high-resolution DNA melt-curve analysis (HRM) as a rapid species identification method. An approach was developed to identify organisms at the pairwise interaction level, with particular application to cryptic species interactions that are traditionally difficult to study. Here, we selected a challenging application; to identify the presence/absence of pathogenic fungi (Sporothrix inflata, Ophiostoma nigrocarpum and Ophiostoma galeiforme) transported by bark beetle vectors (Hylastes ater and Hylurgus ligniperda). The technique was able to distinguish between different species of DNA within a single, pooled sample. In test applications, HRM was effective in the mass screening and identification of pathogenic fungal species carried by many individual bark beetle vectors (n = 455 beetles screened) across large geographic scales. For two of the fungal species, there was no difference in the frequency of association with either of their vectors, but for the third fungal species there was a shift in vector-pathogen associations across locations. This technique allows rapid, mass screening and characterization of species interactions at a fraction of the time and cost of traditional methods. It is anticipated that this method can be readily applied to explore other cryptic species interactions, or other studies requiring rapid generation of large data sets and/or high-throughput efficiency. PMID:23875939

  7. High-throughput avian molecular sexing by SYBR green-based real-time PCR combined with melting curve analysis

    PubMed Central

    Chang, Hsueh-Wei; Cheng, Chun-An; Gu, De-Leung; Chang, Chia-Che; Su, San-Hua; Wen, Cheng-Hao; Chou, Yii-Cheng; Chou, Ta-Ching; Yao, Cheng-Te; Tsai, Chi-Li; Cheng, Chien-Chung

    2008-01-01

    Background Combination of CHD (chromo-helicase-DNA binding protein)-specific polymerase chain reaction (PCR) with electrophoresis (PCR/electrophoresis) is the most common avian molecular sexing technique but it is lab-intensive and gel-required. Gender determination often fails when the difference in length between the PCR products of CHD-Z and CHD-W genes is too short to be resolved. Results Here, we are the first to introduce a PCR-melting curve analysis (PCR/MCA) to identify the gender of birds by genomic DNA, which is gel-free, quick, and inexpensive. Spilornis cheela hoya (S. c. hoya) and Pycnonotus sinensis (P. sinensis) were used to illustrate this novel molecular sexing technique. The difference in the length of CHD genes in S. c. hoya and P. sinensis is 13-, and 52-bp, respectively. Using Griffiths' P2/P8 primers, molecular sexing failed both in PCR/electrophoresis of S. c. hoya and in PCR/MCA of S. c. hoya and P. sinensis. In contrast, we redesigned sex-specific primers to yield 185- and 112-bp PCR products for the CHD-Z and CHD-W genes of S. c. hoya, respectively, using PCR/MCA. Using this specific primer set, at least 13 samples of S. c. hoya were examined simultaneously and the Tm peaks of CHD-Z and CHD-W PCR products were distinguished. Conclusion In this study, we introduced a high-throughput avian molecular sexing technique and successfully applied it to two species. This new method holds a great potential for use in high throughput sexing of other avian species, as well. PMID:18269737

  8. Analysis of tipping-curve measurements performed at the DSS-13 beam-waveguide antenna at 32.0 and 8.45 GigaHertz

    NASA Technical Reports Server (NTRS)

    Morabito, D. D.; Skjerve, L.

    1995-01-01

    This article reports on the analysis of the Ka-band Antenna Performance Experiment tipping-curve data acquired at the DSS-13 research and development beam-waveguide (BWG) antenna. By measuring the operating system temperatures as the antenna is moved form zenith to low-elevation angles and fitting a model to the data, one can obtain information on how well the overall temperature model behaves at zenith and approximate the contribution due to the atmosphere. The atmospheric contribution estimated from the data can be expressed in the form of (1) atmospheric noise temperatures that can provide weather statistic information and be compared against those estimated from other methods and (2) the atmospheric loss factor used to refer efficiency measurements to zero atmosphere. This article reports on an analysis performed on a set of 68 8.4-GHz and 67 32-GHz tipping-curve data sets acquired between December 1993 and May 1995 and compares the results with those inferred from a surface model using input meteorological data and from water vapor radiometer (WVR) data. The general results are that, for a selected subset of tip curves, (1) the BWG tipping-curve atmospheric temperatures are in good agreement with those determined from WVR data (the average difference is 0.06 +/- 0.64 K at 32 GHz) and (2) the surface model average values are biased 3.6 K below those of the BWG and WVR at 32 GHz.

  9. Fast recession of a west antarctic glacier

    PubMed

    Rignot

    1998-07-24

    Satellite radar interferometry observations of Pine Island Glacier, West Antarctica, reveal that the glacier hinge-line position retreated 1.2 +/- 0.3 kilometers per year between 1992 and 1996, which in turn implies that the ice thinned by 3.5 +/- 0.9 meters per year. The fast recession of Pine Island Glacier, predicted to be a possible trigger for the disintegration of the West Antarctic Ice Sheet, is attributed to enhanced basal melting of the glacier floating tongue by warm ocean waters. PMID:9677195

  10. On the minimally invasive approach to the gingival recession

    PubMed Central

    Jargin, Sergei V.

    2013-01-01

    Some aspects of pathogenesis and therapeutic approach to the gingival recession are discussed in this short communication with the example of a typical case from Russia, where excessive socket curettage after a tooth extraction resulted in a marked gingival recession. Subgingival plaque and calculus can be secondary to recession. An argument about plaque as a source of microorganisms might be plausible in case of inflammation, although various microorganisms are normal for the oral cavity. From the viewpoint of general pathology, being an atrophic condition, recession can progress due to repeated damage. On the author's opinion, calculus removal is not indicated at least for aged patients with marked gingival recession, having modest esthetic demands. Socket curettage after exodontia should be gentle. Surgical treatment of the gingival recession is beyond the scope of this communication. PMID:24049345

  11. ECS 178 Course Notes B EZIER CURVES ARE B-SPLINE CURVES

    E-print Network

    California at Davis, University of

    ECS 178 Course Notes B ´EZIER CURVES ARE B-SPLINE CURVES Kenneth I. Joy Institute for Data Analysis, this is obvious. Since B-Spline curves are piecewise B´ezier curves, it follows directly that a single B´ezier curve must be a B-Spline. You are right! But it is also informative to "find" a B´ezier curve

  12. Rapid detection of isoniazid resistance in Mycobacterium tuberculosis isolates by use of real-time-PCR-based melting curve analysis.

    PubMed

    Hu, Siyu; Li, Guoli; Li, Hui; Liu, Xiaoli; Niu, Jianjun; Quan, Shengmao; Wang, Feng; Wen, Huixin; Xu, Ye; Li, Qingge

    2014-05-01

    The MeltPro TB/INH assay, recently approved by the Chinese Food and Drug Administration, is a closed-tube, dual-color, melting curve analysis-based, real-time PCR test specially designed to detect 30 isoniazid (INH) resistance mutations in katG position 315 (katG 315), the inhA promoter (positions -17 to -8), inhA position 94, and the ahpC promoter (positions -44 to -30 and -15 to 3) of Mycobacterium tuberculosis. Here we evaluated both the analytical performance and clinical performance of this assay. Analytical studies with corresponding panels demonstrated that the accuracy for detection of different mutation types (10 wild-type samples and 12 mutant type samples), the limit of detection (2×10(3) to 2×10(4) bacilli/ml), reproducibility (standard deviation [SD], <0.4°C), and the lowest heteroresistance level (40%) all met the parameters preset by the kit. The assay could be run on five types of real-time PCR machines, with the shortest running time (105 min) obtained with the LightCycler 480 II. Clinical studies enrolled 1,096 clinical isolates collected from three geographically different tuberculosis centers, including 437 INH-resistant isolates and 659 INH-susceptible isolates characterized by traditional drug susceptibility testing on Löwenstein-Jensen solid medium. The clinical sensitivity and specificity of the MeltPro TB/INH assay were 90.8% and 96.4%, respectively. DNA sequencing analysis showed that, except for the 5 mutants outside the detection range of the MeltPro assay, a concordance rate between the two methods of 99.1% (457/461) was obtained. Among the 26 mutation types detected, katG S315T (AGC?ACC), inhA -15C?T, katG S315N (AGC?AAC), and ahpC promoter -10C?T accounted for more than 90%. Overall, the MeltPro TB/INH assay represents a reliable and rapid tool for the detection of INH resistance in clinical isolates. PMID:24599986

  13. Coverage of gingival recession using tunnel connective tissue graft technique

    PubMed Central

    Khuller, Nitin

    2009-01-01

    The recession of gingiva is increasingly becoming a more prominent condition in the oral health of many patients and should be treated at its earliest detection. The multi-factorial etiology, decision modality, and current trends followed in treatment of gingival recession are discussed in this presentation. The correction of class I and II gingival recessions are presented as a means of minimizing surgical trauma and achieving predictable aesthetic results. In this case report, I present an alternative technique in treating gingival recession- the tunnel connective tissue graft. PMID:20407659

  14. Carrier testing for autosomal-recessive disorders.

    PubMed

    Vallance, Hilary; Ford, Jason

    2003-08-01

    The aim of carrier testing is to identify carrier couples at risk of having offspring with a serious genetic (autosomal recessive) disorder. Carrier couples are offered genetic consultation where their reproductive options, including prenatal diagnosis, are explained. The Ashkenazi Jewish population is at increased risk for several recessively inherited disorders (Tay-Sachs disease, Cystic fibrosis, Canavan disease, Gaucher disease, Familial Dysautonomia, Niemann-Pick disease, Fanconi anemia, and Bloom syndrome). Unlike Tay-Sachs disease, there is no simple biochemical or enzymatic test to detect carriers for these other disorders. However, with the rapid identification of disease-causing genes in recent years, DNA-based assays are increasingly available for carrier detection. Approximately 5% of the world's population carries a mutation affecting the globin chains of the hemoglobin molecule. Among the most common of these disorders are the thalassemias. The global birth rate of affected infants is at least 2 per 1000 (in unscreened populations), with the greatest incidence in Southeast Asian, Indian, Mediterranean, and Middle Eastern ethnic groups. Carriers are detected by evaluation of red cell indices and morphology, followed by more sophisticated hematological testing and molecular analyses. The following issues need to be considered in the development of a carrier screening program: (1) test selection based on disease severity and test accuracy; (2) funding for testing and genetic counselling; (3) definition of the target population to be screened; (4) development of a public and professional education program; (5) informed consent for screening; and (6) awareness of community needs. PMID:14582604

  15. Autosomal recessive nonsyndromic deafness genes: a review

    PubMed Central

    Duman, Duygu; Tekin, Mustafa

    2013-01-01

    More than 50 percent of prelingual hearing loss is genetic in origin, and of these up to 93 percent are monogenic autosomal recessive traits. Some forms of genetic deafness can be recognized by their associated syndromic features, but in most cases, hearing loss is the only finding and is referred to as nonsyndromic deafness. To date, more than 700 different mutations have been identified in one of 42 genes in individuals with autosomal recessive nonsyndromic hearing loss (ARNSHL). Reported mutations in GJB2, encoding connexin 26, makes this gene the most common cause of hearing loss in many populations. Other relatively common deafness genes include SLC26A4, MYO15A, OTOF, TMC1, CDH23, and TMPRSS3. In this report we summarize genes and mutations reported in families with ARNSHL. Founder effects were demonstrated for some recurrent mutations but the most significant findings are the extreme locus and allelic heterogeneity and different spectrum of genes and mutations in each population. PMID:22652773

  16. Hubble's law and Superluminity Recession Velocities

    E-print Network

    Leonid S. Sitnikov

    2006-05-16

    The extension of the so-called "empty" (with gravity and antigravity that compensate each other in full or do not exist at all) universe and cosmological redshift in it are considered in this paper. Its flat space-time can be submitted not only as manifold with Friedman-Robertson-Walker metrics (FRW) of the general theory of relativity (GR) but also as space-time with usual Minkowski metrics (M-metrics) of the special theory of relativity (SR); the transfer of metrics can be done by suitable transformation of reference frame. Both below-mentioned statements are equally fair for such the universe. First: the distant galaxies can have superluminity recession velocities in FRW-space of GR; we have no right to use here the formula of relativistic Doppler effect. Secondly: the SR theory is fair in the M-space and, accordingly, recession velocities of the same galaxies here can aspire to the speed of light only. In this article it is shown that, despite opposite pictures in FRW-and M- spaces, in the careful account of all details both approaches yield results agreed among them. Thus, actually there are no contradictions between the interpretations of cosmological redshift, based on SR and GR.

  17. Influence curves for factor loadings.

    PubMed

    Kwan, C W; Fung, W K

    2005-11-01

    Influence curves for the initial and rotated loadings are derived for the maximum likelihood factor analysis (MLFA) model. Cook's distances based on the empirical influence curves of factor loadings are proposed for the identification of influential observations. The distances are shown to be invariant under scale transformation and factor rotation. We find that an observation with a very large Cook's distance based on the sample influence curve may not necessarily exert an excessive influence on the factor loadings pattern but may change the ordering of the factors. The issue of the switching of factors is also studied by means of the empirical influence curve and factor scores. PMID:16293205

  18. Discrimination of Closely-Spaced Geosynchronous Satellites - Phase Curve Analysis & New Small Business Innovative Research (SBIR) Efforts

    NASA Astrophysics Data System (ADS)

    Levan, P.

    2010-09-01

    Geosynchronous objects appear as unresolved blurs even when observed with the largest ground-based telescopes. Due to the lack of any spatial detail, two or more objects appearing at similar brightness levels within the spectral bandpass they are observed are difficult to distinguish. Observing a changing pattern of such objects from one time epoch to another showcases the deficiencies in associating individual objects before and after the configuration change. This paper explores solutions to this deficiency in the form of spectral (under small business innovative research) and phase curve analyses. The extension of the technique to phase curves proves to be a powerful new capability.

  19. Adolescents' physical activity at recess and actions to promote a physically active school day in four Finnish schools.

    PubMed

    Haapala, H L; Hirvensalo, M H; Laine, K; Laakso, L; Hakonen, H; Lintunen, T; Tammelin, T H

    2014-10-01

    The national Finnish Schools on the Move programme support schools with their individual plans to promote school-based physical activity (PA). We examined the changes in adolescents' recess and overall PA in four lower secondary schools and described the school actions to promote students' PA and the local contact persons' perceptions of the effects. Recess and overall PA were assessed four times by anonymous questionnaires from students in grades 7-9 (n = 789) in 2010-12, and local contact persons (n = 7) provided information on school actions with diaries, interviews and surveys. Student data were analysed with descriptive statistics and chi-square tests, and school actions data were analysed with quantitative content analysis. The proportion of students who participated in physical activities at recess at least sometimes increased from 30% to 49% in physically active play and from 33% to 42% in ball games, mostly due to improvements in males' participation. Females' participation in recess activities increased in two schools with gender-specific physical activities or facilities. Overall PA levels declined slightly. Organized recess activities, student recess activators and equipment provision and sports facilities development were considered to have affected students' PA positively. Solutions for getting females more physically active in the school setting are needed. PMID:24906635

  20. Detection of Ehrlichia canis in canine blood samples by real-time fluorescence resonance energy transfer (FRET) PCR and melting curve analysis.

    PubMed

    Kongklieng, Amornmas; Thanchomnang, Tongjit; Intapan, Pewpan M; Boonmars, Thidarut; Janwan, Penchom; Sanpool, Oranuch; Lulitanond, Viraphong; Taweethavonsawat, Piyanan; Chungpivat, Sudchit; Morakote, Nimit; Maleewong, Wanchai

    2014-09-01

    Ehrlichia canis is a small pleomorphic gram-negative, coccoid, obligatory intracellular bacterium and the cause of canine monocytic ehrlichiosis. A real-time fluorescence resonance energy transfer polymerase chain reaction (real-time FRET PCR) coupled with melting curve analysis was established for detection of E. canis infection in canine blood samples. The VirB9 gene was amplified using one pair of primers and the melting curve analysis was generated by heating the hybridizing probes and amplified products. Eight E. canis-infected dog blood samples were initially identified using the Giemsa staining/microscopic method followed by conventional PCR (cPCR)/Sanger sequencing for confirmation. The sensitivity and specificity of the real-time FRET PCR detection were 87.5% and 100%, respectively and the limit of detection was 6.6 x 10(3) copies of positive E. canis control plasmids. The real-time FRET PCR with melting curve analysis reported here is better than microscopic visualization or cPCR because the method is not affected by the false bias inherent in the microscopic method. Furthermore, many samples can be processed rapidly at the same time. This convenient tool is beneficial as an alternative assay for the epidemiologic study of canine ehrlichiosis as well as for eradication of these organisms in prevention and control programs in endemic areas. PMID:25417518

  1. SMOOTHING SPLINE GROWTH CURVES WITH COVARIATES

    E-print Network

    SMOOTHING SPLINE GROWTH CURVES WITH COVARIATES Kurt S. Riedel and Kaya Imre Courant Institute splines, Multivariate analysis, Generalized crossvalidation, Adaptive splines, Fusion physics. ABSTRACT We adapt the interactive spline model of Wahba to growth curves with covariates. The smoothing spline

  2. A Novel Mutation in the Transglutaminase-1 Gene in an Autosomal Recessive Congenital Ichthyosis Patient

    PubMed Central

    Vaigundan, D.; Kalmankar, Neha V.; Krishnappa, J.; Gowda, N. Yellappa; Kutty, A. V. M.; Krishnaswamy, Patnam R.

    2014-01-01

    Structure-function implication on a novel homozygous Trp250/Gly mutation of transglutaminase-1 (TGM1) observed in a patient of autosomal recessive congenital ichthyosis is invoked from a bioinformatics analysis. Structural consequences of this mutation are hypothesized in comparison to homologous enzyme human factor XIIIA accepted as valid in similar structural analysis and are projected as guidelines for future studies at an experimental level on TGM1 thus mutated. PMID:25180191

  3. Differential School Effects among Low, Middle, and High Social Class Composition Schools: A Multiple Group, Multilevel Latent Growth Curve Analysis

    ERIC Educational Resources Information Center

    Palardy, Gregory J.

    2008-01-01

    This study uses large-scale survey data and a multiple group, multilevel latent growth curve model to examine differential school effects between low, middle, and high social class composition public schools. The results show that the effects of school inputs and school practices on learning differ across the 3 subpopulations. Moreover, student…

  4. A Statistical Comparison of the Blossom Blight Forecasts of MARYBLYT and Cougarblight with Receiver Operating Characteristic Curve Analysis

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Blossom blight forecasting is an important aspect of fire blight, caused by Erwinia amylovora, management for both apple and pear. A comparison of the forecast accuracy of two common fire blight forecasters, MARYBLYT and Cougarblight, was performed with receiver operating characteristic (ROC) curve ...

  5. First Precision Light Curve Analysis of the Neglected Extreme Mass Ratio Solar-type Binary HR Bootis

    NASA Astrophysics Data System (ADS)

    Samec, Ronald G.; Benkendorf, Barry; Dignan, James B.; Robb, Russell; Kring, James; Faulkner, Danny R.

    2015-04-01

    HR Bootis is a neglected binary that is found to be a solar-type (G2V) extreme mass ratio binary (EMRB). It was discovered by Hanley & Shapley in 1940. Surprisingly, little has been published in the intervening years. In 1999 it was characterized by a 0.31587 day orbital period. Since that time it has been observed by various observers who have determined ?20 timings of minimum light over the past ?15,000 orbits. Our observations in 2012 represent the first precision curves in the BVRcIc Johnson–Cousins wavelength bands. The light curves have rather low amplitudes, averaging some 0.5 magnitudes, yet they exhibit total eclipses, which is typical of the rare group of solar-type EMRBs. An improved linear ephemeris was computed along with a quadratic ephemeris showing a decaying orbit, which indicates magnetic breaking may be occurring. The light curve solution reveals that HR Boo is a contact system with a somewhat low 21% Roche-lobe fill-out but a mass ratio of q = 4.09 (0.2444), which defines it as an EMRB. Two spots, both hot, were allowed to iterate to fit the light curve asymmetries. Their radii are 32° and 16°. Both are high-latitude polar spots indicative of strong magnetic activity. The shallow contact yet nearly equal component temperatures makes it an unusual addition to this group.

  6. Learning Curve for Identification of Sentinel Lymph Node Based on a Cumulative Sum Analysis in Gastric Cancer

    Microsoft Academic Search

    J. H. Lee; K. W. Ryu; S. E. Lee; S. J. Cho; C. G. Kim; I. J. Choi; M. C. Kook; M. J. Kim; S. R. Park; J. S. Lee; B. H. Nam; Y. W. Kim

    2009-01-01

    Background\\/Aims: Lymph node metastasis is the most important point to consider when deciding on the modality of resection in patients with early gastric cancer. This study was conducted to evaluate the learning curve for identification of sentinel lymph nodes in patients with gastric cancer. Methods: The investigators included the results from 2 prospective series of sentinel lymph node mapping. Cumulative

  7. A Unified Latent Curve, Latent State-Trait Analysis of the Developmental Trajectories and Correlates of Positive Orientation

    ERIC Educational Resources Information Center

    Alessandri, Guido; Caprara, Gian Vittorio; Tisak, John

    2012-01-01

    Literature documents that the judgments people hold about themselves, their life, and their future are important ingredients of their psychological functioning and well-being and are commonly related to each other. In this article, results from a longitudinal study (N = 298, 45% males) are presented. Using an integrative Latent Curve, Latent…

  8. Curves and Their Properties.

    ERIC Educational Resources Information Center

    Yates, Robert C.

    This volume, a reprinting of a classic first published in 1952, presents detailed discussions of 26 curves or families of curves, and 17 analytic systems of curves. For each curve the author provides a historical note, a sketch or sketches, a description of the curve, a discussion of pertinent facts, and a bibliography. Depending upon the curve,…

  9. Withholding Recess from Elementary School Students: Policies Matter

    ERIC Educational Resources Information Center

    Turner, Lindsey; Chriqui, Jamie F.; Chaloupka, Frank J.

    2013-01-01

    Background: Recess is a key aspect of a healthy elementary school environment and helps to keep students physically active during the school day. Although national organizations recommend that students not be withheld from recess, this practice occurs in schools. This study examined whether district policies were associated with school practices…

  10. Children's Recess Physical Activity: Movement Patterns and Preferences

    ERIC Educational Resources Information Center

    Woods, Amelia Mays; Graber, Kim C.; Daum, David Newman

    2012-01-01

    The benefits of recess can be reaped by all students regardless of socioeconomic status, race, or gender and at relatively little cost. The purpose of this study was to examine physical activity (PA) variables related to the recess PA patterns of third and fourth grade children and the social preferences and individuals influencing their PA…

  11. Mechanisms of Disease: autosomal dominant and recessive polycystic kidney diseases

    Microsoft Academic Search

    Peter C Harris; Vicente E Torres

    2006-01-01

    Autosomal dominant polycystic kidney disease and autosomal recessive polycystic kidney disease are the best known of a large family of inherited diseases characterized by the development of renal cysts of tubular epithelial cell origin. Autosomal dominant and recessive polycystic kidney diseases have overlapping but distinct pathogeneses. Identification of the causative mutated genes and elucidation of the function of their encoded

  12. The Impact of the Recession on College Students

    ERIC Educational Resources Information Center

    Berg-Cross, Linda; Green, Rodney

    2010-01-01

    This article had three goals: (a) to provide a brief economic review of the relationship between recessionary times, institutional reactions, and the life trajectory of recession-era college students; (b) to discuss the recession-related psychosocial stressors facing today's college students; and (c) to discuss how counseling centers can help…

  13. Drinking In the Age of the Great Recession

    Microsoft Academic Search

    Judith A. Richman; Kathleen M. Rospenda; Timothy P. Johnson; Young Ilk Cho; Ganga Vijayasira; Lea Cloninger; Jennifer M. Wolff

    2012-01-01

    The United States has experienced the most severe economic crisis since the Great Depression. This paper presents an instrument (Life Change Consequences of the Great Recession; LCCGR) depicting work and personal life-related stressors reflecting the enduring effects of the Great Recession. A national sample of 663 respondents completed a mail survey including this instrument and measures of drinking outcomes. Multiple

  14. CASE REPORT Open Access Autosomal recessive cerebellar ataxia caused

    E-print Network

    Paris-Sud XI, Université de

    CASE REPORT Open Access Autosomal recessive cerebellar ataxia caused by mutations in the PEX2 gene Objective: To expand the spectrum of genetic causes of autosomal recessive cerebellar ataxia (ARCA). Case strongly suggested a peroxisomal biogenesis disorder. Sequencing of candidate PEX genes revealed

  15. An exome sequencing strategy to diagnose lethal autosomal recessive disorders

    PubMed Central

    Ellard, Sian; Kivuva, Emma; Turnpenny, Peter; Stals, Karen; Johnson, Matthew; Xie, Weijia; Caswell, Richard; Lango Allen, Hana

    2015-01-01

    Rare disorders resulting in prenatal or neonatal death are genetically heterogeneous. For some conditions, affected fetuses can be diagnosed by ultrasound scan, but this is not usually possible until mid-gestation. There is often limited fetal DNA available for investigation. We investigated a strategy for diagnosing autosomal recessive lethal disorders in non-consanguineous pedigrees with multiple affected fetuses. Exome sequencing was performed to identify genes where each parent is heterozygous for a rare non-synonymous-coding or splicing variant. Putative pathogenic variants were tested for cosegregation in affected fetuses and unaffected siblings. In eight couples of European ancestry, we found on average 1.75 genes (range 0–4) where both parents were heterozygous for rare potentially deleterious variants. A proof-of-principle study detected heterozygous DYNC2H1 variants in a couple whose five fetuses had short-rib polydactyly. Prospective analysis of two couples with multiple pregnancy terminations for fetal akinesia syndrome was performed and a diagnosis was obtained in both the families. The first couple were each heterozygous for a previously reported GLE1 variant, p.Arg569His or p.Val617Met; both were inherited by their two affected fetuses. The second couple were each heterozygous for a novel RYR1 variant, c.14130-2A>G or p.Ser3074Phe; both were inherited by their three affected fetuses but not by their unaffected child. Biallelic GLE1 and RYR1 disease-causing variants have been described in other cases with fetal akinesia syndrome. We conclude that exome sequencing of parental samples can be an effective tool for diagnosing lethal recessive disorders in outbred couples. This permits early prenatal diagnosis in future pregnancies. PMID:24961629

  16. 40 CFR 798.5275 - Sex-linked recessive lethal test in drosophila melanogaster.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ...Sex-linked recessive lethal test in drosophila melanogaster. 798.5275 Section...Sex-linked recessive lethal test in drosophila melanogaster. (a) Purpose. ...recessive lethal (SLRL) test using Drosophila melanogaster detects the...

  17. 40 CFR 798.5275 - Sex-linked recessive lethal test in drosophila melanogaster.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ...Sex-linked recessive lethal test in drosophila melanogaster. 798.5275 Section...Sex-linked recessive lethal test in drosophila melanogaster. (a) Purpose. ...recessive lethal (SLRL) test using Drosophila melanogaster detects the...

  18. 40 CFR 798.5275 - Sex-linked recessive lethal test in drosophila melanogaster.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ...Sex-linked recessive lethal test in drosophila melanogaster. 798.5275 Section...Sex-linked recessive lethal test in drosophila melanogaster. (a) Purpose. ...recessive lethal (SLRL) test using Drosophila melanogaster detects the...

  19. 40 CFR 798.5275 - Sex-linked recessive lethal test in drosophila melanogaster.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ...Sex-linked recessive lethal test in drosophila melanogaster. 798.5275 Section...Sex-linked recessive lethal test in drosophila melanogaster. (a) Purpose. ...recessive lethal (SLRL) test using Drosophila melanogaster detects the...

  20. 40 CFR 798.5275 - Sex-linked recessive lethal test in drosophila melanogaster.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ...Sex-linked recessive lethal test in drosophila melanogaster. 798.5275 Section...Sex-linked recessive lethal test in drosophila melanogaster. (a) Purpose. ...recessive lethal (SLRL) test using Drosophila melanogaster detects the...

  1. Analysis of MOST light curves of five young stars in Taurus-Auriga and Lupus~3 Star Forming Regions

    E-print Network

    Siwak, Michal; Matthews, Jaymie M; Kuschnig, Rainer; Guenther, David B; Moffat, Anthony F J; Sasselov, Dimitar; Weiss, Werner W

    2011-01-01

    Continuous photometric observations of five young stars obtained by the MOST satellite in 2009 and 2010 in the Taurus and Lupus star formation regions are presented. Using light curve modelling under the assumption of internal invariability of spots, we obtained small values of the solar-type differential-rotation parameter (k=0.0005-0.009) for three spotted weak-line T Tau stars, V410 Tau, V987 Tau and Lupus 3-14; for another spotted WTTS, Lupus 3-48, the data are consistent with a rigidly rotating surface (k=0). Three flares of similar rise (4 min 30 sec) and decay (1 h 45 min) times were detected in the light curve of Lupus 3-14. The brightness of the classical T Tau star RY Tau continuously decreased over 3 weeks of its observations with a variable modulation not showing any obvious periodic signal.

  2. Television Viewing and Adolescents’ Judgment of Sexual Request Scripts: A Latent Growth Curve Analysis in Early and Middle Adolescence

    Microsoft Academic Search

    Steven Eggermont

    2006-01-01

    A longitudinal study was conducted to explore the relationship between television viewing and beliefs about expressing sexual\\u000a desire in dating situations. In three consecutive years, a panel of early adolescents (N?=?883) and a panel of middle adolescents (N?=?651) rated the effectiveness of a sexual approach and a romantic approach. Latent growth curve analyses indicate that between\\u000a the ages of 12

  3. Developmental changes in group climate in two types of group therapy for binge-eating disorder: A growth curve analysis

    Microsoft Academic Search

    Giorgio A. Tasca; Louise Balfour; Kerri Ritchie; Hany Bissada

    2006-01-01

    The development of group climate across 16 sessions of group psychodynamic–interpersonal psychotherapy (GPIP) and group cognitive–behavioral therapy (GCBT) for 65 female treatment completers with binge-eating disorder (BED) was assessed. Engaged scale growth for GPIP patients varied across sessions and was best represented by a cubic growth curve. This suggested that GPIP progressed in definable phases that reflected a rupture and

  4. Efficacy of atomoxetine in adult attention-Deficit\\/Hyperactivity Disorder: a drug-placebo response curve analysis

    Microsoft Academic Search

    Stephen V Faraone; Joseph Biederman; Thomas Spencer; David Michelson; Lenard Adler; Fred Reimherr; Stephen J Glatt

    2005-01-01

    BACKGROUND: The objective of this study was to evaluate the efficacy of atomoxetine, a new and highly selective inhibitor of the norepinephrine transporter, in reducing symptoms of attention-deficit\\/hyperactivity disorder (ADHD) among adults by using drug-placebo response curve methods. METHODS: We analyzed data from two double-blind, placebo-controlled, parallel design studies of adult patients (Study I, N = 280; Study II, N

  5. Whole-genome amplified DNA from stored dried blood spots is reliable in high resolution melting curve and sequencing analysis

    Microsoft Academic Search

    Bo G Winkel; Mads V Hollegaard; Morten S Olesen; Jesper H Svendsen; Stig Haunsø; David M Hougaard; Jacob Tfelt-Hansen

    2011-01-01

    BACKGROUND: The use of dried blood spots (DBS) samples in genomic workup has been limited by the relative low amounts of genomic DNA (gDNA) they contain. It remains to be proven that whole genome amplified DNA (wgaDNA) from stored DBS samples, constitutes a reliable alternative to gDNA. We wanted to compare melting curves and sequencing results from wgaDNA derived from

  6. Human Capital, Social Support, and Economic Well-being among Rural, Low-income Mothers: A Latent Growth Curve Analysis

    Microsoft Academic Search

    Leigh Ann Simmons; Bonnie Braun; David W. Wright; Scott R. Miller

    2007-01-01

    The purpose of this study was to better understand human capital and social support in the long-term economic well-being of\\u000a rural, low-income mothers in the US. Three waves of data from a multi-state, longitudinal investigation tracking the well-being\\u000a of rural families, known as “Rural Families Speak,” were used to test two latent growth curve models of economic well-being.\\u000a Results indicated

  7. A transit timing analysis of seven RISE light curves of the exoplanet system HAT-P-3

    NASA Astrophysics Data System (ADS)

    Gibson, N. P.; Pollacco, D. L.; Barros, S.; Benn, C.; Christian, D.; Hrudková, M.; Joshi, Y. C.; Keenan, F. P.; Simpson, E. K.; Skillen, I.; Steele, I. A.; Todd, I.

    2010-01-01

    We present seven light curves of the exoplanet system HAT-P-3, taken as part of a transit timing programme using the rapid imager to search for exoplanets instrument on the Liverpool Telescope. The light curves are analysed using a Markov chain Monte Carlo algorithm to update the parameters of the system. The inclination is found to be i = 86.75+0.22-0.21°, the planet-star radius ratio to be Rp/R* = 0.1098+0.0010-0.0012 and the stellar radius to be R* = 0.834+0.018-0.026Rsolar, consistent with previous results but with a significant improvement in the precision. Central transit times and uncertainties for each light curve are also determined, and a residual permutation algorithm is used as an independent check on the errors. The transit times are found to be consistent with a linear ephemeris, and a new ephemeris is calculated as Tc(0) = 2454856.70118 +/- 0.00018 HJD and P = 2.899738 +/- 0.000007 d. Model timing residuals are fitted to the measured timing residuals to place upper mass limits for a hypothetical perturbing planet as a function of the period ratio. These show that we have probed for planets with masses as low as 0.33 and 1.81 M? in the interior and exterior 2:1 resonances, respectively, assuming the planets are initially in circular orbits.

  8. Light-curve analysis of KIC 12557548b: an extrasolar planet with a comet-like tail

    NASA Astrophysics Data System (ADS)

    Budaj, J.

    2014-03-01

    We will demonstrate how amateur observations with small telescopes of ε Aur (a bright eclipsing binary with the longest known orbital period) help to understand the nature of this object and how the understanding of physical processes in this object helps to understand superb Kepler observations of KIC 12557548b (an extremely short-period transiting exoplanet with a comet-like tail). We modified the code SHELLSPEC, which is designed for modelling interacting binary stars to calculate the light curves of such planets. Mie absorption and scattering on spherical dust grains with realistic dust opacities, phase functions, and a finite radius of the source of the scattered light are taken into account. We prove that the peculiar light curve of this exoplanet agrees with the idea of a planet with a comet-like tail. The light curve has a prominent pre-transit brightening and a less prominent post-transit brightening. Both are caused by the forward scattering and are a strong function of the particle size. This feature enabled us to estimate a typical particle size (radius) in the dust tail of about 0.1-1 μm. However, there is an indication that the particle size changes (decreases) along the tail. The dust density in the tail is a steep decreasing function of the distance from the planet, which indicates a significant tail destruction caused by the star-planet interaction. Several possible combinations of other dust properties are tabulated. We reveal interesting periodic long-term evolution of the tail on a time scale of about 1.3 years and also argue that the 'planet' does not show a uniform behaviour, but may have at least two constituents. This exoplanet's tail evolution may find an analogy in the comet tail disconnection events caused by the magnetic/coronal activity of the Sun while the light curve with pre-transit brightening is analogous to the light curve of ε Aur and AZ Cas with mid-eclipse brightening and forward scattering playing a significant role in such eclipsing systems.

  9. Recession of periodontal ligament as an indicator of age.

    PubMed

    Solheim, T

    1992-12-01

    The recession of the periodontal ligament has been used as one of several indicators of age in methods for age estimation. In a sample of 1000 teeth the relationship between age and periodontal recession was studied for each type of tooth. Only a weak correlation was found, the least weak being for premolars. The mean of the periodontal recession measured in mm showed approximately the same correlation as when assessed by scoring systems. Logarithmic transformation of the mean of the recession resulted in a stronger correlation with age. The use of tooth age rather than individual age did not have the same effect. Periodontal recession tended to be more rapid in males than in females. The reason for extraction was not found to be significantly correlated with periodontal recession. In conclusion, periodontal recession was not sufficiently accurate to be used as a sole indicator of age. However, in multiple regression methods for age estimation it might contribute significantly to the age equation, especially for premolars. PMID:1342054

  10. Refined hierarchical kinematics quasi-3D Ritz models for free vibration analysis of doubly curved FGM shells and sandwich shells with FGM core

    NASA Astrophysics Data System (ADS)

    Fazzolari, Fiorenzo A.; Carrera, Erasmo

    2014-02-01

    In this paper, the Ritz minimum energy method, based on the use of the Principle of Virtual Displacements (PVD), is combined with refined Equivalent Single Layer (ESL) and Zig Zag (ZZ) shell models hierarchically generated by exploiting the use of Carrera's Unified Formulation (CUF), in order to engender the Hierarchical Trigonometric Ritz Formulation (HTRF). The HTRF is then employed to carry out the free vibration analysis of doubly curved shallow and deep functionally graded material (FGM) shells. The PVD is further used in conjunction with the Gauss theorem to derive the governing differential equations and related natural boundary conditions. Donnell-Mushtari's shallow shell-type equations are given as a particular case. Doubly curved FGM shells and doubly curved sandwich shells made up of isotropic face sheets and FGM core are investigated. The proposed shell models are widely assessed by comparison with the literature results. Two benchmarks are provided and the effects of significant parameters such as stacking sequence, boundary conditions, length-to-thickness ratio, radius-to-length ratio and volume fraction index on the circular frequency parameters and modal displacements are discussed.

  11. Fourier Descriptors for Plane Closed Curves

    Microsoft Academic Search

    Charles T. Zahn; Ralph Z. Roskies

    1972-01-01

    A method for the analysis and synthesis of closed curves in the plane is developed using the Fourier descriptors FD's of Cosgriff [1]. A curve is represented parametrically as a function of arc length by the accumulated change in direction of the curve since the starting point. This function is expanded in a Fourier series and the coefficients are arranged

  12. Permanent prostate brachytherapy: Dosimetric results and analysis of a learning curve with a dynamic dose-feedback technique

    SciTech Connect

    Acher, Peter [Department of Urology, Guy's and St. Thomas' NHS Foundation Trust, London (United Kingdom)]. E-mail: peter.acher@gstt.nhs.uk; Popert, Rick [Department of Urology, Guy's and St. Thomas' NHS Foundation Trust, London (United Kingdom); Nichol, Janette [Department of Urology, Guy's Hospital, London (United Kingdom); Potters, Louis [New York Prostate Institute, South Nassau Communities Hospital, Oceanside, NY (United States); Morris, Stephen [Department of Clinical Oncology, Guy's and St. Thomas' NHS Foundation Trust, London (United Kingdom); Beaney, Ronald [Department of Clinical Oncology, Guy's and St. Thomas' NHS Foundation Trust, London (United Kingdom)

    2006-07-01

    Purpose: A permanent prostate brachytherapy (PPB) program utilizing intraoperative inverse-planned dynamic dose-feedback was initiated without prior firsthand experience of alternative techniques. The purpose of this study is to assess the dosimetric learning curve associated with this approach. Methods and Materials: A total of 77 patients underwent PPB implants as monotherapy for localized prostate cancer to a prescription dose of 145 Gy with loose 125I seeds between December 2003 and June 2004. Intraoperative and postoperative dosimetric values, total implanted radioactivity, and operating room (OR) times were compared by sequential case number for all cases. Results: The median intraoperative dosimetric values were: D90 (the minimum dose to 90% of the prostate) = 170 Gy (range, 135-203 Gy), V100 (the volume of the prostate that receives 100% of the prescription dose) = 96% (range, 86-100), V150 = 66% (range, 34-86). Median postoperative dosimetric values were as follows: D90 = 168 Gy (range, 132-197 Gy), V100 = 95% (range, 86-99), V150 = 74% (range, 51-84). Median implanted activity was 0.79 mCi per cubic centimeter of prostate (range, 0.541-1.13). There was no significant correlation by case number on any postoperative dosimetric parameter studied. Door-to-door OR time was reduced from median 138 to 97.5 min per case at the end of the series with a correlation coefficient of -0.76 for the initial 28 cases. Conclusion: Satisfactory dosimetric parameters can be achieved from the outset without a learning curve effect in an appropriately trained environment. The learning curve for dynamic dose-feedback PPB in a clinic naive to other techniques is apparent in terms of OR time.

  13. Direct Analysis of JV-Curves Applied to an Outdoor-Degrading CdTe Module (Presentation)

    SciTech Connect

    Jordan, D; Kurtz, S.; Ulbrich, C.; Gerber, A.; Rau, U.

    2014-03-01

    We present the application of a phenomenological four parameter equation to fit and analyze regularly measured current density-voltage JV curves of a CdTe module during 2.5 years of outdoor operation. The parameters are physically meaningful, i.e. the short circuit current density Jsc, open circuit voltage Voc and differential resistances Rsc, and Roc. For the chosen module, the fill factor FF degradation overweighs the degradation of Jsc and Voc. Interestingly, with outdoor exposure, not only the conductance at short circuit, Gsc, increases but also the Gsc(Jsc)-dependence. This is well explained with an increase in voltage dependent charge carrier collection in CdTe.

  14. Arbitrarily Curved and Twisted Space Beams. Ph.D. Thesis - Va. Polytech. Inst. and State Univ.; [Elastic Deformation, Stress Analysis

    NASA Technical Reports Server (NTRS)

    Hunter, W. F.

    1974-01-01

    A derivation of the equations which govern the deformation of an arbitrarily curved and twisted space beam is presented. These equations differ from those of the classical theory in that (1) extensional effects are included; (2) the strain-displacement relations are derived; and (3) the expressions for the stress resultants are developed from the strain displacement relations. It is shown that the torsional stress resultant obtained by the classical approach is basically incorrect except when the cross-section is circular. The governing equations are given in the form of first-order differential equations. A numerical algorithm is given for obtaining the natural vibration characteristics and example problems are presented.

  15. Atlas of fatigue curves

    SciTech Connect

    Boyer, H.E.

    1986-01-01

    This Atlas was developed to serve engineers who are looking for fatigue data on a particular metal or alloy. Having these curves compiled in a single book will also facilitate the computerization of the involved data. It is pointed out that plans are under way to make the data in this book available in ASCII files for analysis by computer programs. S-N curves which typify effects of major variables are considered along with low-carbon steels, medium-carbon steels, alloy steels, HSLA steels, high-strength alloy steels, heat-resisting steels, stainless steels, maraging steels, cast irons, and heat-resisting alloys. Attention is also given to aluminum alloys, copper alloys, magnesium alloys, molybdenum, tin alloys, titanium and titanium alloys, zirconium, steel castings, closed-die forgings, powder metallurgy parts, composites, effects of surface treatments, and test results for component parts.

  16. Autosomal recessive polycystic kidney disease: long-term outcome of neonatal survivors

    Microsoft Academic Search

    Sushmita Roy; Michael J. Dillon; Richard S. Trompeter; T. Martin Barratt

    1997-01-01

    .  ?Autosomal recessive polycystic kidney disease causes renal and hepatic dysfunction in childhood. We describe the clinical\\u000a outcome of 52 children with this diagnosis born between 1950 and 1993. Currently 23 are alive, 24 dead and 5 have been lost\\u000a to follow-up; 1 has been dialysed and 7 transplanted. Life-table analysis of the patients surviving the 1st month of life\\u000a revealed

  17. Fine mapping of an incomplete recessive gene for leaf rolling in rice ( Oryza sativa L.)

    Microsoft Academic Search

    Yuanjian Shao; Cunhong Pan; Zongxiang Chen; Shimin Zuo; Yafang Zhang; Xuebiao Pan

    2005-01-01

    Genetic analysis and fine mapping of genes controlling leaf rolling were conducted using two backcrossed generations (BC4F2, BC4F3) derived from a cross between QMX, a non-rolled leaf cultivar as a recurrent parent, and JZB, a rolled leaf NIL of ZB as\\u000a a donor parent. Results indicated that leaf rolling was mainly controlled by an incompletely recessive major gene, namelyrl\\u000a (t),

  18. Laminar flow in a recess of a hydrostatic bearing

    NASA Technical Reports Server (NTRS)

    San Andres, Luis A.; Velthuis, Johannes F. M.

    1992-01-01

    The flow in a recess of a hydrostatic journal bearing is studied in detail. The Navier-Stokes equations for the laminar flow of an incompressible liquid are solved numerically in a two-dimensional plane of a typical bearing recess. Pressure- and shear-induced flows, as well as a combination of these two flow conditions, are analyzed. Recess friction, pressure-ram effects at discontinuities in the flow region, and film entrance pressure loss effects are calculated. Entrance pressure loss coefficients over a forward-facing step are presented as functions of the mean flow Reynolds number for pure-pressure and shear-induced laminar flows.

  19. Economic recession and headache-related hospital admissions.

    PubMed

    Chinta, Ravi; Rao, M B; Narendran, Vivek; Malla, Ganesh; Joshi, Hem

    2013-01-01

    Incidence of headaches across different regions and its relationship to unemployment rates in the United States before and during an economic recession was evaluated. Years 2008 and 2009 were determined as recessionary period. Headache-related admissions, particularly the uncomplicated headaches, increased significantly during recession. Proportion of women with headaches has increased and the age group of 25-54 years was the most affected during the recession. The hospital charges have increased even though the average length and charge of stay decreased. These findings are consistent with our understanding of effects of stress and unemployment on psychological and physical health. PMID:23822548

  20. Iceland Glacier Recession 1973 to 2000, Glacier Terminus contrast emphasized

    NSDL National Science Digital Library

    Lori Perkins

    2001-04-09

    This animation shows glacier recesion at the Breidamerkurjokull glacier in Iceland. The data from 1973 is taken from Landsat 1 and the 2000 data is from Landsat 7. The Breidamerkurjokull glacier in Iceland has been measured by Landsat to be receding since 1973. The glacierologists in Iceland and here at Nasas Goddard Space Flight Center have measured the recession throughout the entire glacier and found different rates of recession in different areas. In genral, the glacier seems to be receding at about 2% annually. It is extremely controversial whether this recession is caused by global warming.

  1. Automatic Classification of X-rated Videos using Obscene Sound Analysis based on a Repeated Curve-like Spectrum Feature

    E-print Network

    Lim, JaeDeok; Han, SeungWan; Lee, ChoelHoon

    2011-01-01

    This paper addresses the automatic classification of X-rated videos by analyzing its obscene sounds. In this paper, obscene sounds refer to audio signals generated from sexual moans and screams during sexual scenes. By analyzing various sound samples, we determined the distinguishable characteristics of obscene sounds and propose a repeated curve-like spectrum feature that represents the characteristics of such sounds. We constructed 6,269 audio clips to evaluate the proposed feature, and separately constructed 1,200 X-rated and general videos for classification. The proposed feature has an F1-score, precision, and recall rate of 96.6%, 98.2%, and 95.2%, respectively, for the original dataset, and 92.6%, 97.6%, and 88.0% for a noisy dataset of 5dB SNR. And, in classifying videos, the feature has more than a 90% F1-score, 97% precision, and an 84% recall rate. From the measured performance, X-rated videos can be classified with only the audio features and the repeated curve-like spectrum feature is suitable to...

  2. Analysis of MOST light curves of five young stars in Taurus-Auriga and Lupus 3 star-forming regions

    NASA Astrophysics Data System (ADS)

    Siwak, Michal; Rucinski, Slavek M.; Matthews, Jaymie M.; Kuschnig, Rainer; Guenther, David B.; Moffat, Anthony F. J.; Sasselov, Dimitar; Weiss, Werner W.

    2011-08-01

    Continuous photometric observations of five young stars obtained by the MOST satellite in 2009 and 2010 in the Taurus and Lupus star formation regions are presented. Using light-curve modelling under the assumption of internal invariability of spots, we obtained small values of the solar-type differential-rotation parameter (k = 0.0005-0.009) for three spotted weak-line T Tauri stars, V410 Tau, V987 Tau and Lupus 3-14; for another spotted weak-line T Tauri star (WTTS), Lupus 3-48, the data are consistent with a rigidly rotating surface (k = 0). Three flares of similar rise (4 min and 30 s) and decay (1 h and 45 min) times were detected in the light curve of Lupus 3-14. The brightness of the classical T Tauri star RY Tau continuously decreased over 3 weeks of its observations with a variable modulation not showing any obvious periodic signal. Based on data from the MOST satellite, a Canadian Space Agency mission, jointly operated by Dynacon Inc., the University of Toronto Institute of Aerospace Studies and the University of British Columbia, with the assistance of the University of Vienna.

  3. An Exploratory Analysis of Personality, Attitudes, and Study Skills on the Learning Curve within a Team-based Learning Environment

    PubMed Central

    Henry, Teague; Campbell, Ashley

    2015-01-01

    Objective. To examine factors that determine the interindividual variability of learning within a team-based learning environment. Methods. Students in a pharmacokinetics course were given 4 interim, low-stakes cumulative assessments throughout the semester and a cumulative final examination. Students’ Myers-Briggs personality type was assessed, as well as their study skills, motivations, and attitudes towards team-learning. A latent curve model (LCM) was applied and various covariates were assessed to improve the regression model. Results. A quadratic LCM was applied for the first 4 assessments to predict final examination performance. None of the covariates examined significantly impacted the regression model fit except metacognitive self-regulation, which explained some of the variability in the rate of learning. There were some correlations between personality type and attitudes towards team learning, with introverts having a lower opinion of team-learning than extroverts. Conclusion. The LCM could readily describe the learning curve. Extroverted and introverted personality types had the same learning performance even though preference for team-learning was lower in introverts. Other personality traits, study skills, or practice did not significantly contribute to the learning variability in this course. PMID:25861101

  4. CONSTRUCTION OF AN EARTH MODEL: ANALYSIS OF EXOPLANET LIGHT CURVES AND MAPPING THE NEXT EARTH WITH THE NEW WORLDS OBSERVER

    SciTech Connect

    Oakley, P. H. H.; Cash, W. [Center for Astrophysics and Space Astronomy, University of Colorado, Boulder, CO, 80309 (United States)], E-mail: Phil.Oakley@Colorado.edu

    2009-08-01

    The orbital light curve of a terrestrial exoplanet will likely contain valuable information about the surface and atmospheric features of the planet, both in its overall shape and hourly variations. We have constructed an empirically based code capable of simulating observations of the Earth from any orientation, at any time of year with continuously updated cloud and snow coverage with a New Worlds Observatory. By simulating these observations over a full orbital revolution at a distance of 10 pc we determine that the detection of an obliquity or seasonal terrain change is possible at low inclinations. In agreement with other studies, a 4 m New Worlds Observer can accurately determine the rotation rate of the planet at a success rate from {approx}30% to 80% with only 5 days of observations depending on the signal to noise of the observations. We also attempt simple inversions of these diurnal light curves to sketch a map of the reflecting planet's surface features. This mapping technique is only successful with highly favorable systems and in particular requires that the cloud coverage must be lower than the Earth's average. Our test case of a 2 M {sub +} planet at 7 pc distance with low exo-zodiacal light and 25% cloud coverage produced crude, but successful results. Additionally, with these highly favorable systems NWO may be able to discern the presence of liquid surface water (or other smooth surfaces) though it requires a complex detection available only at crescent phases in high inclination systems.

  5. Gonadal (ovarian) dysgenesis in 46,XX individuals: Frequency of the autosomal recessive form

    SciTech Connect

    Meyers, C.M.; Boughman, J.A. [Univ. of Maryland, Baltimore, MD (United States)] [Univ. of Maryland, Baltimore, MD (United States); Rivas, M. [Univ. of Tennessee, Memphis, TN (United States)] [and others] [Univ. of Tennessee, Memphis, TN (United States); and others

    1996-06-28

    Gonadal (ovarian) dysgenesis with normal chromosomes (46,XX) clearly is a heterogeneous condition. In some forms, the defect is restricted to the gonads, whereas other affected females show neurosensory hearing loss (Perrault syndrome). In another form, brothers may have germ cell aplasia. Nongenetic causes exist as well. To elucidate the proportion of XX gonadal (ovarian) dysgenesis due to autosomal recessive genes, we analyzed published (N = 17) and unpublished (N = 8) families having at least two female offspring. Analysis was restricted to cases in whom ovarian failure was documented by the presence of streak ovaries (published cases) or elevated gonadotropins (unpublished cases). We reasoned that the closer to that segregation ratio expected for an autosomal recessive trait (0.25), the lower the frequency of nongenetic forms. Segregation analysis utilized standard correction for single ascertainment, with only females included in the preliminary analysis. The segregation ratio estimate was 0.16. Our results suggest that many 46,XX females with gonadal (ovarian) dysgenesis represent a disorder segregating as an autosomal recessive trait, placing sisters of these cases at a 25% risk for this disorder. 32 refs., 2 figs., 1 tab.

  6. Urbanization and the global malaria recession

    PubMed Central

    2013-01-01

    Background The past century has seen a significant contraction in the global extent of malaria transmission, resulting in over 50 countries being declared malaria free, and many regions of currently endemic countries eliminating the disease. Moreover, substantial reductions in transmission have been seen since 1900 in those areas that remain endemic today. Recent work showed that this malaria recession was unlikely to have been driven by climatic factors, and that control measures likely played a significant role. It has long been considered, however, that economic development, and particularly urbanization, has also been a causal factor. The urbanization process results in profound socio-economic and landscape changes that reduce malaria transmission, but the magnitude and extent of these effects on global endemicity reductions are poorly understood. Methods Global data at subnational spatial resolution on changes in malaria transmission intensity and urbanization trends over the past century were combined to examine the relationships seen over a range of spatial and temporal scales. Results/Conclusions A consistent pattern of increased urbanization coincident with decreasing malaria transmission and elimination over the past century was found. Whilst it remains challenging to untangle whether this increased urbanization resulted in decreased transmission, or that malaria reductions promoted development, the results point to a close relationship between the two, irrespective of national wealth. The continuing rapid urbanization in malaria-endemic regions suggests that such malaria declines are likely to continue, particularly catalyzed by increasing levels of direct malaria control. PMID:23594701

  7. Economic recession and mental health: an overview.

    PubMed

    Cooper, Brian

    2011-01-01

    Effects of the current global economic downturn on population mental health will emerge in the years ahead. Judging from earlier experience of financial crises in various parts of the world, stresses associated with rising unemployment, poverty and social insecurity will lead to upward trends in many national suicide rates, as well as to less readily charted increase in the prevalence of psychiatric illness, alcohol-related disorders and illicit drug use. At the same time, mental health services are being cut back as part of government austerity programs. Budget cuts will thus affect psychiatric services adversely just when economic stressors are raising the levels of need and demand in affected populations. Proactive fiscal and social policies could, however, help to mitigate the health consequences of recession. Evidence- based preventive measures include active labor market and family support programs, regulation of alcohol prices and availability, community care for known high-risk groups, and debt relief projects. Economic mental health care could best be achieved, not by decimating services but by planning and deploying these to meet the needs of defined area populations. PMID:21968374

  8. Factoring integers with elliptic curves

    Microsoft Academic Search

    H. W. Lenstra

    1987-01-01

    Abstract This paper is devoted to the description and analysis of a new algorithm to factor positive integers. It depends on the use of elliptic curves. The new method is obtained from,Pollard's (p — l)-method (Proc. Cambridge,Philos. Soc. 76 (1974), 521-528) by replacing the multiplicative group by the group of points on a random,elliptic curve. It is conjectured,that the algorithm,determines,a

  9. On the use of spring baseflow recession for a more accurate parameterization of aquifer transit time distribution functions

    NASA Astrophysics Data System (ADS)

    Farlin, J.; Maloszewski, P.

    2012-12-01

    Baseflow recession analysis and groundwater dating have up to now developed as two distinct branches of hydrogeology and were used to solve entirely different problems. We show that by combining two classical models, namely Boussinesq's Equation describing spring baseflow recession and the exponential piston-flow model used in groundwater dating studies, the parameters describing the transit time distribution of an aquifer can be in some cases estimated to a far more accurate degree than with the latter alone. Under the assumption that the aquifer basis is sub-horizontal, the mean residence time of water in the saturated zone can be estimated from spring baseflow recession. This provides an independent estimate of groundwater residence time that can refine those obtained from tritium measurements. This approach is demonstrated in a case study predicting atrazine concentration trend in a series of springs draining the fractured-rock aquifer known as the Luxembourg Sandstone. A transport model calibrated on tritium measurements alone predicted different times to trend reversal following the nationwide ban on atrazine in 2005 with different rates of decrease. For some of the springs, the best agreement between observed and predicted time of trend reversal was reached for the model calibrated using both tritium measurements and the recession of spring discharge during the dry season. The agreement between predicted and observed values was however poorer for the springs displaying the most gentle recessions, possibly indicating the stronger influence of continuous groundwater recharge during the dry period.

  10. On the use of spring baseflow recession for a more accurate parameterization of aquifer transit time distribution functions

    NASA Astrophysics Data System (ADS)

    Farlin, J.; Maloszewski, P.

    2013-05-01

    Baseflow recession analysis and groundwater dating have up to now developed as two distinct branches of hydrogeology and have been used to solve entirely different problems. We show that by combining two classical models, namely the Boussinesq equation describing spring baseflow recession, and the exponential piston-flow model used in groundwater dating studies, the parameters describing the transit time distribution of an aquifer can be in some cases estimated to a far more accurate degree than with the latter alone. Under the assumption that the aquifer basis is sub-horizontal, the mean transit time of water in the saturated zone can be estimated from spring baseflow recession. This provides an independent estimate of groundwater transit time that can refine those obtained from tritium measurements. The approach is illustrated in a case study predicting atrazine concentration trend in a series of springs draining the fractured-rock aquifer known as the Luxembourg Sandstone. A transport model calibrated on tritium measurements alone predicted different times to trend reversal following the nationwide ban on atrazine in 2005 with different rates of decrease. For some of the springs, the actual time of trend reversal and the rate of change agreed extremely well with the model calibrated using both tritium measurements and the recession of spring discharge during the dry season. The agreement between predicted and observed values was however poorer for the springs displaying the most gentle recessions, possibly indicating a stronger influence of continuous groundwater recharge during the summer months.

  11. Isolated Curves for Hyperelliptic Curve Cryptography

    E-print Network

    Wang, Wenhan

    2012-01-01

    We introduce the notion of isolated genus two curves. As there is no known efficient algorithm to explicitly construct isogenies between two genus two curves with large conductor gap, the discrete log problem (DLP) cannot be efficiently carried over from an isolated curve to a large set of isogenous curves. Thus isolated genus two curves might be more secure for DLP based hyperelliptic curve cryptography. We establish results on explicit expressions for the index of an endomorphism ring in the maximal CM order, and give conditions under which the index is a prime number or an almost prime number for three different categories of quartic CM fields. We also derived heuristic asymptotic results on the densities and distributions of isolated genus two curves with CM by any fixed quartic CM field. Computational results, which are also shown for three explicit examples, agree with heuristic prediction with errors within a tolerable range.

  12. Recessive Uaa Suppressors of the Yeast SACCHAROMYCES CEREVISIAE

    PubMed Central

    Ono, Bun-Ichiro; Tanaka, Mitsuaki; Kominami, Masayo; Ishino, Yumiko; Shinoda, Sumio

    1982-01-01

    Recessive lysine-independent revertants were isolated from a ?+ haploid strain of the yeast Saccharomyces cerevisiae containing one of the leucine-inserting UAA suppressors, SUP29, and various UAA mutations including lys1-1. The majority of the revertants were found to have recessive suppressors in addition to the pre-existing SUP29 mutation. The recessive suppressors were able to suppress only a very limited number of UAA mutations, and none of the UAG mutations thus far examined. The recessive inefficient UAA suppressors were assigned to three complementation groups, sup111, sup112, and sup113. A high incidence of gene conversion was observed for an allele of sup111. An antisuppressor acting on sup111, but not detectably on SUP29, was inadvertently obtained during the course of the study. Interactions between SUP29, sup111 and the antisuppressor asu12 were studied. PMID:6821248

  13. Chemical-mechanical polishing of recessed microelectromechanical devices

    DOEpatents

    Barron, Carole C. (Albuquerque, NM); Hetherington, Dale L. (Albuquerque, NM); Montague, Stephen (Albuquerque, NM)

    1999-01-01

    A method is disclosed for micromachining recessed layers (e.g. sacrificial layers) of a microelectromechanical system (MEMS) device formed in a cavity etched into a semiconductor substrate. The method uses chemical-mechanical polishing (CMP) with a resilient polishing pad to locally planarize one or more of the recessed layers within the substrate cavity. Such local planarization using the method of the present invention is advantageous for improving the patterning of subsequently deposited layers, for eliminating mechanical interferences between functional elements (e.g. linkages) of the MEMS device, and for eliminating the formation of stringers. After the local planarization of one or more of the recessed layers, another CMP step can be provided for globally planarizing the semiconductor substrate to form a recessed MEMS device which can be integrated with electronic circuitry (e.g. CMOS, BiCMOS or bipolar circuitry) formed on the surface of the substrate.

  14. Chemical-mechanical polishing of recessed microelectromechanical devices

    DOEpatents

    Barron, C.C.; Hetherington, D.L.; Montague, S.

    1999-07-06

    A method is disclosed for micromachining recessed layers (e.g. sacrificial layers) of a microelectromechanical system (MEMS) device formed in a cavity etched into a semiconductor substrate. The method uses chemical-mechanical polishing (CMP) with a resilient polishing pad to locally planarize one or more of the recessed layers within the substrate cavity. Such local planarization using the method of the present invention is advantageous for improving the patterning of subsequently deposited layers, for eliminating mechanical interferences between functional elements (e.g. linkages) of the MEMS device, and for eliminating the formation of stringers. After the local planarization of one or more of the recessed layers, another CMP step can be provided for globally planarizing the semiconductor substrate to form a recessed MEMS device which can be integrated with electronic circuitry (e.g., CMOS, BiCMOS or bipolar circuitry) formed on the surface of the substrate. 23 figs.

  15. Genetics Home Reference: Autosomal recessive axonal neuropathy with neuromyotonia

    MedlinePLUS

    ... intolerance) and can lead to an unusual walking style (gait), frequent falls, and joint deformities (contractures) in ... Where can I find information about diagnosis or management of autosomal recessive axonal neuropathy with neuromyotonia? You ...

  16. Recessed Downlights: A New Take on an Old Standby

    SciTech Connect

    Gordon, Kelly L.; McCullough, Jeffrey J.

    2004-01-02

    Recessed can downlights are a very popular form of lighting with many new homes containing 20 or more can lights. This trade magazine article describes PNNL's work with DOE's Emerging Technologies Program to promote energy-efficient recessed can downlights. PNNL manages the Recessed Can Downlights Project, which encourages manufacturers to produce energy-efficient recessed cans and tests them to verify that they have the following features: use pin-based CFL bulbs rated for 10,000 hours of life; use airtight housing to prevent air leakage into attics; are IC-rated for direct contact with insulation; have electronic ballasts for quiet, flicker-free operation; and have a min. light output of 900 initial lumens. Can lights that qualify are promoted through a DOE website. This is under DOE's Office of Energy Efficiency and Renewable Energy Building Technologies Program.

  17. Recessive resistance genes against potyviruses are localized in colinear genomic regions of the tomato ( Lycopersicon spp.) and pepper ( Capsicum spp.) genomes

    Microsoft Academic Search

    G. Parrella; S. Ruffel; A. Moretti; C. Morel; A. Palloix; C. Caranta

    2002-01-01

    Resistance against both Potato virus Y (PVY) and Tobacco etch virus (TEV) was identified in the wild tomato relative Lycopersicon hirsutum PI247087. Analysis of the segregation ratio in F2\\/F3 and BC1 interspecific progenies indicated that a single recessive gene, or two very tightly linked recessive loci, are involved in resistance to both potyviruses. This locus was named pot-1. Using amplified

  18. Analysis of noise produced by jet impingement near the trailing edge of a flat and a curved plate

    NASA Technical Reports Server (NTRS)

    Mckinzie, D. J., Jr.; Burns, R. J.

    1975-01-01

    The sound fields produced by the interaction of a subsonic cold gas jet with the trailing edge of a large flat plate and a curved plate were analyzed. The analyses were performed to obtain a better understanding of the dominant noise source and the mechanism governing the peak sound-pressure-level frequencies of the broadband spectra. An analytical expression incorporating an available theory and experimental data predicts sound field data over an arc of approximately 105 deg measured from the upstream jet axis for the two independent sets of data. The dominant noise as detected on the impingement side of either plate results from the jet impact (eighth power of the velocity dependence) rather than a trailing-edge disturbance (fifth or sixth power of the velocity dependence). Also, the frequency of the peak SPL may be governed by a phenomenon which produces periodic formation and shedding of ring vortices from the nozzle lip.

  19. The effect of physical activity on depression in adolescence and emerging adulthood: A growth-curve analysis.

    PubMed

    McPhie, Meghan L; Rawana, Jennine S

    2015-04-01

    This study examined the influence of physical activity on the trajectory of depression from adolescence through emerging adulthood (EA). Using data from the National Longitudinal Study of Adolescent Health (Waves I to IV), latent growth curve modeling was performed to assess how physical activity and gender influenced depression across adolescence and EA. Higher levels of physical activity in mid-adolescence were associated with lower levels of depression during mid-adolescence and slower inclines and declines in depression over time. Boys had lower levels of depression in mid-adolescence and slower inclines and declines in depression over time compared to girls. Findings provide evidence that current theories on understanding depression and mental health prevention programs may be enhanced by the inclusion of physical activity. PMID:25721258

  20. Analysis of progress curves for a highly concentrated Michaelian enzyme in the presence or absence of product inhibition.

    PubMed Central

    Kellershohn, N; Laurent, M

    1985-01-01

    Methods are given for analysing the time course of an enzyme-catalysed reaction when the concentration of the enzyme itself is high, a situation which is often found in vivo. (1) The integrated form of the kinetic equation for a concentrated Michaelian enzyme in absence of product inhibition is given. Parameters are shown to be calculated easily using non-linear fitting procedures. (2) A general algorithm to analyse progress-curve data in more complex cases (i.e. when the analytical form of the integrated rate equation is not known or is exceedingly complex) is proposed. This algorithm may be used for any enzyme mechanism for which the differential form of the kinetic equation may be written analytically. We show that the method allows differentiation between the main types of product inhibition which may occur in the case of a highly concentrated Michaelian enzyme. PMID:4062893

  1. Mutations induced in Tradescantia by small doses of X-rays and neutrons - Analysis of dose-response curves.

    NASA Technical Reports Server (NTRS)

    Sparrow, A. H.; Underbrink, A. G.; Rossi, H. H.

    1972-01-01

    Dose-response curves for pink somatic mutations in Tradescantia stamen hairs were analyzed after neutron and X-ray irradiation with doses ranging from a fraction of a rad to the region of saturation. The dose-effect relation for neutrons indicates a linear dependence from 0.01 to 8 rads; between 0.25 and 5 rads, a linear dependence is indicated for X-rays also. As a consequence the relative biological effectiveness reaches a constant value (about 50) at low doses. The observations are in good agreement with the predictions of the theory of dual radiation action and support its interpretation of the effects of radiation on higher organisms. The doubling dose of X-rays was found to be nearly 1 rad.

  2. Analysis of the long-term behavior of solute transport with nonlinear equilibrium sorption using breakthrough curves and temporal moments.

    PubMed

    Vereecken, H; Jaekel, U; Schwarze, H

    2002-06-01

    We analyzed the long-term behavior of breakthrough curves (BTCs) and temporal moments of a solute subjected to Freundlich equilibrium sorption (s = kc(n)). For one-dimensional transport in a homogeneous porous medium, we derived a power-law relation between travel time, tau, and solute displacement, chi, with the exponent being equal to the Freundlich n exponent. The mean solute velocity, derived from the first time moment, was found to change as tau(n-1). For n values larger than 0.66, the second time moment could be related to c chi(2/n), where c is a constant. An approach based on the use of a critical concentration was developed to estimate the presence of the asymptotic regime in the tail of the BTC. This approach was tested successfully using numerical case studies. One-dimensional numerical simulations with varying values of k, n and initial mass were run to verify the closed form analytical expressions for the large time behavior of temporal moments and the tailing part of breakthrough curves. Good agreement between the slope of the tailing part of log-log transformed BTCs and the predicted slope using asymptotic theory was found. Asymptotic theory in general underestimated the magnitude of the concentration in the tail. The quality of the estimated concentrations in the tail improved for small values of the dispersivity. Experimental BTCs of uranin and benazolin were analyzed in combination with sorption/desorption batch experiments using asymptotic theory. A good agreement between the value of n parameter derived from desorption experiment with benazolin and the value of the n parameter derived from the tail of the BTC was found. PMID:12102322

  3. Children's Physical Activity during Recess and Outside of School

    ERIC Educational Resources Information Center

    Beighle, Aaron; Morgan, Charles F.; Le Masurier, Guy; Pangrazi, Robert P.

    2006-01-01

    The purpose of this study was to examine children's physical activity during recess and outside of school. Third-, fourth-, and fifth-grade students (N = 270; 121 boys, age = 9.5 plus or minus 0.9 years; 150 girls, age = 9.6 plus or minus 0.9 years) wore sealed pedometers during a 15-minute recess period and outside of school for 4 consecutive…

  4. Gas insulated transmission line with insulators having field controlling recesses

    DOEpatents

    Cookson, Alan H. (Pittsburgh, PA); Pederson, Bjorn O. (Chelmsford, MA)

    1984-01-01

    A gas insulated transmission line having a novel insulator for supporting an inner conductor concentrically within an outer sheath. The insulator has a recess contiguous with the periphery of one of the outer and inner conductors. The recess is disposed to a depth equal to an optimum gap for the dielectric insulating fluid used for the high voltage insulation or alternately disposed to a large depth so as to reduce the field at the critical conductor/insulator interface.

  5. Production Recesses for Replaceable Cutting Inserts of Milling Tools

    NASA Astrophysics Data System (ADS)

    Kousal, Lukáš; Sadílek, Marek

    2014-12-01

    This article describes the production of recesses for replaceable cutting inserts of milling tools. The recess manufacture is exemplified on a D20 shanktype milling cutter with three replaceable cutting inserts. A new production technology and its operating cycle are demonstrated. A com-parison of the old and the new technologies shows the percentage saving of change cycles and used tools, including overall evaluation of the tech-nology.

  6. Remote Recession Sensing of Ablative Heat Shield Materials

    NASA Technical Reports Server (NTRS)

    Winter, Michael W.; Stackpoole, Margaret; Nawaz, Anuscheh; Gonzales, Gregory Lewis; Ho, Thanh

    2014-01-01

    Material recession and charring are two major processes determining the performance of ablative heat shield materials. Even in ground testing, the characterization of these two mechanisms relies on measurements of material thickness before and after testing, thus providing only information integrated over the test time. For recession measurements, optical methods such as imaging the sample surface during testing are under investigation but require high alignment and instrument effort, therefore being not established as a standard measurement method. For char depth measurements, the most common method so far consists in investigation of sectioned samples after testing or in the case of Stardust where core extractions were performed to determine char information. In flight, no reliable recession measurements are available, except total recession after recovering the heat shield on ground. Developments of mechanical recession sensors have been started but require substantial on board instrumentation adding mass and complexity. In this work, preliminary experiments to evaluate the feasibility of remote sensing of material recession and possibly char depth through optically observing the emission signatures of seeding materials in the post shock plasma is investigated. It is shown that this method can provide time resolved recession measurements without the necessity of accurate alignment procedures of the optical set-up and without any instrumentation on board of a spacecraft. Furthermore, recession data can be obtained without recovering flight hardware which would be a huge benefit for inexpensive heat shield material testing on board of small re-entry probes, e.g. on new micro-satellite re-entry probes as a possible future application of Cubesats or RBR

  7. A Six-Node Curved Triangular Element and a Four-Node Quadrilateral Element for Analysis of Laminated Composite Aerospace Structures

    NASA Technical Reports Server (NTRS)

    Martin, C. Wayne; Breiner, David M.; Gupta, Kajal K. (Technical Monitor)

    2004-01-01

    Mathematical development and some computed results are presented for Mindlin plate and shell elements, suitable for analysis of laminated composite and sandwich structures. These elements use the conventional 3 (plate) or 5 (shell) nodal degrees of freedom, have no communicable mechanisms, have no spurious shear energy (no shear locking), have no spurious membrane energy (no membrane locking) and do not require arbitrary reduction of out-of-plane shear moduli or under-integration. Artificial out-of-plane rotational stiffnesses are added at the element level to avoid convergence problems or singularity due to flat spots in shells. This report discusses a 6-node curved triangular element and a 4-node quadrilateral element. Findings show that in regular rectangular meshes, the Martin-Breiner 6-node triangular curved shell (MB6) is approximately equivalent to the conventional 8-node quadrilateral with integration. The 4-node quadrilateral (MB4) has very good accuracy for a 4-node element, and may be preferred in vibration analysis because of narrower bandwidth. The mathematical developments used in these elements, those discussed in the seven appendices, have been applied to elements with 3, 4, 6, and 10 nodes and can be applied to other nodal configurations.

  8. [Duplex genotyping of CYP2C19*2 and CYP2C19*3 by high-resolution melting curve analysis].

    PubMed

    Cao, Chun-Ge; Sun, Hai-Yan; Zhou, Fang-Fang; Wang, Shi-Ming; Chen, Hong-Yan; Lu, Da-Ru

    2013-07-01

    Clopidogrel is a widely used anti-platelet agent for the prevention of arterial thrombosis. It has been suggested that clopidogrel may be less effective in inhibiting platelet aggregation among patients who are carriers of CYP2C19*2 and CYP2C19*3, two loss-of-function CYP2C19 alleles, which are associated with reduced conversion of clopidogrel to its active metabolite. The objective of this research was to develop a simple and accurate method for genotyping of CYP2C19*2 and CYP2C19*3 simultaneously in one closed-tube using high-resolution melting curve (HRM) analysis. Two amplicons bracketing CYP2C19*2 and CYP2C19*3 gene variants were designed, and AT- or GC-rich 5' tails were added to selected primers to ensure two different amplicons with non-overlapping melting curves. Sixty-four random DNA samples were all fast and sensitively genotyped by HRM analysis. This method was validated by DNA sequencingtechnique, and genotypes obtained using the HRM approach perfectly matched the genotypes obtained by DNA sequencing technique. Therefore, this HRM-based assay allows simple and accurate duplex genotyping of CYP2C19*2 and CYP2C19*3 simultaneously in one closed-tube. This method is expected to be applied in clinical laboratory to guide indi-vidual dosage design of clopidogrel. PMID:23853364

  9. Composition-explicit distillation curves of diesel fuel with glycol ether and glycol ester oxygenates: fuel analysis metrology to enable decreased particulate emissions.

    PubMed

    Smith, Beverly L; Ott, Lisa S; Bruno, Thomas J

    2008-10-15

    We recently introduced several important improvements in the measurement of distillation curves of complex fluids. The modifications to the classical measurement provide for (1) a composition-explicit data channel for each distillate fraction (for both qualitative and quantitative analysis), (2) temperature measurements that are true thermodynamic state points that can be modeled with an equation of state, (3) temperature, volume, and pressure measurements of low uncertainty suitable for equation of state development, (4) consistency with a century of historical data, (5) an assessment of the energy content of each distillate fraction, (6) trace chemical analysis of each distillate fraction, and (7) corrosivity assessment of each distillate fraction. We have applied the new method to the measurement of rocket propellant, gasolines, jet fuels, and hydrocarbon crude oils. In this paper we presentthe application of the technique to representative diesel fuel and mixtures of diesel fuel with some of the more promising oxygenating agents; namely, the glycol ethers and glycol esters: tri(propylene glycol) methyl ether (TPM), dibutyl maleate (DBM), and an 80/ 20 (vol/vol) mixture of diethylene glycol methyl ether (DGME) + 1,2-dimethoxyethane (DME) a mixture often referred to as Cetaner. We present not only the distillation curves but also a chemical characterization of each fraction, and discuss the contrasts between the various mixtures. The measurements are significant as an environmental design tool for decreased particulate emissions. PMID:18983093

  10. Oxidative Recession, Sulfur Release, and Al203 Spallation for Y-Doped Alloys

    NASA Technical Reports Server (NTRS)

    Smialek, James L.

    2001-01-01

    Second-order spallation phenomena have been noted for Y-doped Rene'N5 after long term oxidation at 1150 degrees C. The reason for this behavior has not been conclusively identified. A mass equivalence analysis has shown that the surface recession resulting from oxidation has the potential of releasing about 0.15 monolayer of sulfur for every 1 mg/sq cm of oxygen reacted for an alloy containing 5 ppmw of sulfur. This amount is significant in comparison to levels that have been shown to result in first-order spallation behavior for undoped alloys. Oxidative recession is therefore speculated to be a contributing source of sulfur and second-order spallation for Y-doped alloys.

  11. Quantitative Fundus Autofluorescence in Recessive Stargardt Disease

    PubMed Central

    Burke, Tomas R.; Duncker, Tobias; Woods, Russell L.; Greenberg, Jonathan P.; Zernant, Jana; Tsang, Stephen H.; Smith, R. Theodore; Allikmets, Rando; Sparrow, Janet R.; Delori, François C.

    2014-01-01

    Purpose. To quantify fundus autofluorescence (qAF) in patients with recessive Stargardt disease (STGD1). Methods. A total of 42 STGD1 patients (ages: 7–52 years) with at least one confirmed disease-associated ABCA4 mutation were studied. Fundus AF images (488-nm excitation) were acquired with a confocal scanning laser ophthalmoscope equipped with an internal fluorescent reference to account for variable laser power and detector sensitivity. The gray levels (GLs) of each image were calibrated to the reference, zero GL, magnification, and normative optical media density to yield qAF. Texture factor (TF) was calculated to characterize inhomogeneities in the AF image and patients were assigned to the phenotypes of Fishman I through III. Results. Quantified fundus autofluorescence in 36 of 42 patients and TF in 27 of 42 patients were above normal limits for age. Young patients exhibited the relatively highest qAF, with levels up to 8-fold higher than healthy eyes. Quantified fundus autofluorescence and TF were higher in Fishman II and III than Fishman I, who had higher qAF and TF than healthy eyes. Patients carrying the G1916E mutation had lower qAF and TF than most other patients, even in the presence of a second allele associated with severe disease. Conclusions. Quantified fundus autofluorescence is an indirect approach to measuring RPE lipofuscin in vivo. We report that ABCA4 mutations cause significantly elevated qAF, consistent with previous reports indicating that increased RPE lipofuscin is a hallmark of STGD1. Even when qualitative differences in fundus AF images are not evident, qAF can elucidate phenotypic variation. Quantified fundus autofluorescence will serve to establish genotype-phenotype correlations and as an outcome measure in clinical trials. PMID:24677105

  12. A distinct Mendelian autosomal recessive syndrome involving the association of anotia, palate agenesis, bifid tongue, and polydactyly in the dog.

    PubMed

    Villagómez, D A; Alonso, R A

    1998-10-01

    A presumed genetic syndrome is described in a family of St. Bernards. Four identically affected littermates presented the association of palate agenesis, anotia, incomplete bifid tongue, preaxial hind paw polydactyly, and an extra thoracic vertebra and rib. Pedigree analysis is compatible with an autosomal recessive gene. PMID:9789676

  13. A Truncating Mutation of TRAPPC9 Is Associated with Autosomal-Recessive Intellectual Disability and Postnatal Microcephaly

    Microsoft Academic Search

    Ganeshwaran H. Mochida; Muhammad Mahajnah; Anthony D. Hill; Lina Basel-Vanagaite; Danielle Gleason; R. Sean Hill; Adria Bodell; Moira Crosier; Rachel Straussberg; Christopher A. Walsh

    2009-01-01

    Although autosomal genes are increasingly recognized as important causes of intellectual disability, very few of them are known. We identified a genetic locus for autosomal-recessive nonsyndromic intellectual disability associated with variable postnatal microcephaly through homozygosity mapping of a consanguineous Israeli Arab family. Sequence analysis of genes in the candidate interval identified a nonsense nucleotide change in the gene that encodes

  14. Barriers for recess physical activity: a gender specific qualitative focus group exploration

    PubMed Central

    2014-01-01

    Background Many children, in particular girls, do not reach the recommended amount of daily physical activity. School recess provides an opportunity for both boys and girls to be physically active, but barriers to recess physical activity are not well understood. This study explores gender differences in children’s perceptions of barriers to recess physical activity. Based on the socio-ecological model four types of environmental barriers were distinguished: natural, social, physical and organizational environment. Methods Data were collected through 17 focus groups (at 17 different schools) with in total 111 children (53 boys) from fourth grade, with a mean age of 10.4 years. The focus groups included an open group discussion, go-along group interviews, and a gender segregated post-it note activity. A content analysis of the post-it notes was used to rank the children’s perceived barriers. This was verified by a thematic analysis of transcripts from the open discussions and go-along interviews. Results The most frequently identified barriers for both boys and girls were weather, conflicts, lack of space, lack of play facilities and a newly-found barrier, use of electronic devices. While boys and girls identified the same barriers, there were both inter- and intra-gender differences in the perception of these barriers. Weather was a barrier for all children, apart from the most active boys. Conflicts were perceived as a barrier particularly by those boys who played ballgames. Girls said they would like to have more secluded areas added to the school playground, even in large schoolyards where lack of space was not a barrier. This aligned with girls’ requests for more “hanging-out” facilities, whereas boys primarily wanted activity promoting facilities. Conclusion Based on the results from this study, we recommend promoting recess physical activity through a combination of actions, addressing barriers within the natural, social, physical and organizational environment. PMID:24958158

  15. The influence of grain-size analysis methods and sediment mixing on curve shapes and textural parameters: Implications for sediment trend analysis

    Microsoft Academic Search

    Burghard W. Flemming

    2007-01-01

    To this day, deterministic physical models capable of explaining the evolution of grain-size distributions in the course of transport are still lacking. For this reason, various attributes of particle frequency distributions, in particular curve shapes and textural parameters, have for many decades been investigated for potential information about transport behaviour and size-sorting processes of sediments in numerous environments. Such approaches

  16. Linkage of autosomal recessive lamellar ichthyosis to chromosome 14q

    SciTech Connect

    Russell, L.J.; Compton, J.G.; Bale, S.J. [National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, MD (United States); DiGiovanna, J.J. [National Cancer Institute, Bethesda, MD (United States); Hashem, N. [Ains-Shams Univ. Medical Genetics Center, Cairo (Egypt)

    1994-12-01

    The authors have mapped the locus for lamellar ichthyosis (LI), an autosomal recessive skin disease characterized by abnormal cornification of the epidermis. Analysis using both inbred and outbred families manifesting severe LI showed complete linkage to several markers within a 9.3-cM region on chromosome 14q11. Affected individuals in inbred families were also found to have striking homozygosity for markers in this region. Linkage-based genetic counseling and prenatal diagnosis is now available for informative at-risk families. Several transcribed genes have been mapped to the chromosome 14 region containing the LI gene. The transglutaminase 1 gene (TGM1), which encodes one of the enzymes responsible for cross-linking epidermal proteins during formation of the stratum corneum, maps to this interval. The TGM1 locus was completely linked to LI (Z = 9.11), suggesting that TGM1 is a good candidate for further investigation of this disorder. The genes for four serine proteases also map to this region but are expressed only in hematopoietic or mast cells, making them less likely candidates.

  17. Elliptic Curves An Introduction

    E-print Network

    Babinkostova, Liljana

    . The growing practical relevance of elliptic curves in modern cryptography is another issue missing. This listElliptic Curves ­ An Introduction ­ Expanded notes from a mini-workshop held at Mary Immaculate. Group law on the cubic curve 29 4. Theta Functions 53 5. Rank two vector bundles on elliptic curves 75

  18. Elliptic Curves Number Theory

    E-print Network

    Babinkostova, Liljana

    Elliptic Curves Number Theory and Cryptography Second Edition © 2008 by Taylor & Francis Group, LLC Washington, Lawrence C. Elliptic curves : number theory and cryptography / Lawrence C. Washington. -- 2nd ed, elliptic curves started being used in cryptography and elliptic curve techniques were developed

  19. Comparative Analysis of the Volatile Components of Agrimonia eupatoria from Leaves and Roots by Gas Chromatography-Mass Spectrometry and Multivariate Curve Resolution.

    PubMed

    Feng, Xiao-Liang; He, Yun-Biao; Liang, Yi-Zeng; Wang, Yu-Lin; Huang, Lan-Fang; Xie, Jian-Wei

    2013-01-01

    Gas chromatography-mass spectrometry and multivariate curve resolution were applied to the differential analysis of the volatile components in Agrimonia eupatoria specimens from different plant parts. After extracted with water distillation method, the volatile components in Agrimonia eupatoria from leaves and roots were detected by GC-MS. Then the qualitative and quantitative analysis of the volatile components in the main root of Agrimonia eupatoria was completed with the help of subwindow factor analysis resolving two-dimensional original data into mass spectra and chromatograms. 68 of 87 separated constituents in the total ion chromatogram of the volatile components were identified and quantified, accounting for about 87.03% of the total content. Then, the common peaks in leaf were extracted with orthogonal projection resolution method. Among the components determined, there were 52 components coexisting in the studied samples although the relative content of each component showed difference to some extent. The results showed a fair consistency in their GC-MS fingerprint. It was the first time to apply orthogonal projection method to compare different plant parts of Agrimonia eupatoria, and it reduced the burden of qualitative analysis as well as the subjectivity. The obtained results proved the combined approach powerful for the analysis of complex Agrimonia eupatoria samples. The developed method can be used to further study and quality control of Agrimonia eupatoria. PMID:24286016

  20. Comparative Analysis of the Volatile Components of Agrimonia eupatoria from Leaves and Roots by Gas Chromatography-Mass Spectrometry and Multivariate Curve Resolution

    PubMed Central

    Feng, Xiao-Liang; He, Yun-biao; Liang, Yi-Zeng; Wang, Yu-Lin; Huang, Lan-Fang; Xie, Jian-Wei

    2013-01-01

    Gas chromatography-mass spectrometry and multivariate curve resolution were applied to the differential analysis of the volatile components in Agrimonia eupatoria specimens from different plant parts. After extracted with water distillation method, the volatile components in Agrimonia eupatoria from leaves and roots were detected by GC-MS. Then the qualitative and quantitative analysis of the volatile components in the main root of Agrimonia eupatoria was completed with the help of subwindow factor analysis resolving two-dimensional original data into mass spectra and chromatograms. 68 of 87 separated constituents in the total ion chromatogram of the volatile components were identified and quantified, accounting for about 87.03% of the total content. Then, the common peaks in leaf were extracted with orthogonal projection resolution method. Among the components determined, there were 52 components coexisting in the studied samples although the relative content of each component showed difference to some extent. The results showed a fair consistency in their GC-MS fingerprint. It was the first time to apply orthogonal projection method to compare different plant parts of Agrimonia eupatoria, and it reduced the burden of qualitative analysis as well as the subjectivity. The obtained results proved the combined approach powerful for the analysis of complex Agrimonia eupatoria samples. The developed method can be used to further study and quality control of Agrimonia eupatoria. PMID:24286016

  1. Design, analysis, and fabrication of a pressure box test fixture for tension damage tolerance testing of curved fuselage panels

    NASA Technical Reports Server (NTRS)

    Smith, P. J.; Bodine, J. B.; Preuss, C. H.; Koch, W. J.

    1993-01-01

    A pressure box test fixture was designed and fabricated to evaluate the effects of internal pressure, biaxial tension loads, curvature, and damage on the fracture response of composite fuselage structure. Previous work in composite fuselage tension damage tolerance, performed during NASA contract NAS1-17740, evaluated the above effects on unstiffened panels only. This work extends the tension damage tolerance testing to curved stiffened fuselage crown structure that contains longitudinal stringers and circumferential frame elements. The pressure box fixture was designed to apply internal pressure up to 20 psi, and axial tension loads up to 5000 lb/in, either separately or simultaneously. A NASTRAN finite element model of the pressure box fixture and composite stiffened panel was used to help design the test fixture, and was compared to a finite element model of a full composite stiffened fuselage shell. This was done to ensure that the test panel was loaded in a similar way to a panel in the full fuselage shell, and that the fixture and its attachment plates did not adversely affect the panel.

  2. Growth Curve Models for the Analysis of Phenotype Arrays for a Systems Biology Overview of Yersinia pestis

    SciTech Connect

    Fodor, I K; Holtz-Morris, A E; McCutchen-Maloney, S L

    2005-09-08

    The Phenotype MicroArray technology of Biolog, Inc. (Hayward, CA) measures the respiration of cells as a function of time in thousands of microwells simultaneously, and thus provides a high-throughput means of studying cellular phenotypes. The microwells contain compounds involved in a number of biochemical pathways, as well as chemicals that test the sensitivity of cells against antibiotics and stress. While the PM experimental workflow is completely automated, statistical methods to analyze and interpret the data are lagging behind. To take full advantage of the technology, it is essential to develop efficient analytical methods to quantify the information in the complex datasets resulting from PM experiments. We propose the use of statistical growth-curve models to rigorously quantify observed differences in PM experiments, in the context of the growth and metabolism of Yersinia pestis cells grown under different physiological conditions. The information from PM experiments complement genomic and proteomic results and can be used to identify gene function and in drug development. Successful coupling of phenomics results with genomics and proteomics will lead to an unprecedented ability to characterize bacterial function at a systems biology level.

  3. Melting Curve Analysis after T Allele Enrichment (MelcaTle) as a Highly Sensitive and Reliable Method for Detecting the JAK2V617F Mutation

    PubMed Central

    Morishita, Soji; Takahashi, Kochi; Araki, Marito; Hironaka, Yumi; Sunami, Yoshitaka; Edahiro, Yoko; Tsutsui, Miyuki; Ohsaka, Akimichi; Tsuneda, Satoshi; Komatsu, Norio

    2015-01-01

    Detection of the JAK2V617F mutation is essential for diagnosing patients with classical myeloproliferative neoplasms (MPNs). However, detection of the low-frequency JAK2V617F mutation is a challenging task due to the necessity of discriminating between true-positive and false-positive results. Here, we have developed a highly sensitive and accurate assay for the detection of JAK2V617F and named it melting curve analysis after T allele enrichment (MelcaTle). MelcaTle comprises three steps: 1) two cycles of JAK2V617F allele enrichment by PCR amplification followed by BsaXI digestion, 2) selective amplification of the JAK2V617F allele in the presence of a bridged nucleic acid (BNA) probe, and 3) a melting curve assay using a BODIPY-FL-labeled oligonucleotide. Using this assay, we successfully detected nearly a single copy of the JAK2V617F allele, without false-positive signals, using 10 ng of genomic DNA standard. Furthermore, MelcaTle showed no positive signals in 90 assays screening healthy individuals for JAK2V617F. When applying MelcaTle to 27 patients who were initially classified as JAK2V617F-positive on the basis of allele-specific PCR analysis and were thus suspected as having MPNs, we found that two of the patients were actually JAK2V617F-negative. A more careful clinical data analysis revealed that these two patients had developed transient erythrocytosis of unknown etiology but not polycythemia vera, a subtype of MPNs. These findings indicate that the newly developed MelcaTle assay should markedly improve the diagnosis of JAK2V617F-positive MPNs. PMID:25794279

  4. Three-dimensional temperature dependent free vibration analysis of functionally graded material curved panels resting on two-parameter elastic foundation using a hybrid semi-analytic, differential quadrature method

    Microsoft Academic Search

    M. Farid; P. Zahedinejad; P. Malekzadeh

    2010-01-01

    In this study, free vibration analysis of initially stressed thick simply supported functionally graded curved panel resting on two-parameter elastic foundation (Pasternak model), subjected in thermal environment is studied using the three-dimensional elasticity formulation. The material properties are temperature dependent and the temperature is assumed to have uniform and non-uniform distributions through the thickness direction of the curved panel. In

  5. Timing of Holocene Glacier Recessions in the Swiss Alps

    NASA Astrophysics Data System (ADS)

    Joerin, U. E.; Stocker, T. F.; Schluechter, C.

    2004-12-01

    Alpine glaciers are sensitive climate indicators on time scales as short as decades to centuries. Periods of cold and wet climatic conditions cause glacial advances and deposition of moraines. Subsequent change to warmer and drier conditions cause glacial recessions. Since the cold event of the Little Ice Age glaciers in the Swiss Alps have retreated substantially exposing high walls of lateral moraines which consist of a stack of overlying till units. Previous work focused on such stacked moraines and the related glacial advances. However, such paleoclimatic reconstructions based only on moraines are incomplete, in particular for periods of glacial recession. This study examines Holocene glacier recessions based on pieces of wood and peat occurring in glaciofluvial deposits of outburst flood events. These subfossil remains indicate that (i) glaciers were once smaller than present, (ii) climate conditions allowed vegetation growth and a higher treeline elevation than today, (iii) sequences of glaciofluvial gravels and lodgement tills accumulated in now glaciated basins. We focus in this study on three climaticly different re-gions: i.e. Unteraar Glacier (Central Alps), Tschierva Glacier (Eastern Alps) and Ried Glacier (South Central Alps). The conventional radiocarbon and AMS dating was used to determine the age of more than 140 samples of wood and peat fragments. The results show that glacier recessions occurred in distinct phases throughout the Holocene, synchronously in different Alpine regions. The total duration of recession phases is longer than 5500 yr or > 50 % of the Holocene epoch. The glacial recessions are separated by glacial advances, which occurred in time periods shorter than 400 yr. A comparison of our Holocene record of glacier length variations with the ice rafted debris events in the North Atlantic, the Be-10 record of ice cores and atmospheric ? 14C suggest a combination of solar and North Atlantic forcing. Thus, situations of glacial recession, to the extent of smaller glaciers than present, occurred throughout the Holocene.

  6. Development of a nomogram incorporating serum C-reactive protein level to predict overall survival of patients with advanced urothelial carcinoma and its evaluation by decision curve analysis

    PubMed Central

    Ishioka, J; Saito, K; Sakura, M; Yokoyama, M; Matsuoka, Y; Numao, N; Koga, F; Masuda, H; Fujii, Y; Kawakami, S; Kihara, K

    2012-01-01

    Background: The purpose of this study is to investigate the prognostic impact of C-reactive protein (CRP) on patients with advanced urothelial carcinoma and to develop a novel nomogram predicting survival. Methods: A total of 223 consecutive patients were treated at Tokyo Medical and Dental Hospital. A nomogram incorporating V was developed based on the result of a Cox proportional hazards model. Its efficacy and clinical usefulness was evaluated by concordance index (c-index) and decision curve analysis. Results: Of the 223 patients, 184 (83%) died of cancer. Median follow-up periods of patients who died and those who remained alive were 5 and 11 months, respectively. We developed a novel nomogram incorporating Eastern Cooperative Oncology Group Performance Status, presence of visceral metastasis, haemoglobin and age. The c-index of the nomogram predicting survival probability 6 and 12 months after diagnosis was 0.788 and 0.765, respectively. Decision curve analyses revealed that the novel nomogram incorporating CRP had a superior net benefit than that without CRP for most of the examined probabilities. Conclusion: We demonstrated the prognostic impact of CRP that improved the predictive accuracy of a nomogram for survival probability in patients with advanced urothelial carcinoma. PMID:22918396

  7. Identification of CHIP as a Novel Causative Gene for Autosomal Recessive Cerebellar Ataxia

    PubMed Central

    Shi, Yuting; Wang, Junling; Li, Jia-Da; Ren, Haigang; Guan, Wenjuan; He, Miao; Yan, Weiqian; Zhou, Ying; Hu, Zhengmao; Zhang, Jianguo; Xiao, Jingjing; Su, Zheng; Dai, Meizhi; Wang, Jun; Jiang, Hong; Guo, Jifeng; Zhou, Yafang; Zhang, Fufeng; Li, Nan; Du, Juan; Xu, Qian; Hu, Yacen; Pan, Qian; Shen, Lu; Wang, Guanghui; Xia, Kun; Zhang, Zhuohua; Tang, Beisha

    2013-01-01

    Autosomal recessive cerebellar ataxias are a group of neurodegenerative disorders that are characterized by complex clinical and genetic heterogeneity. Although more than 20 disease-causing genes have been identified, many patients are still currently without a molecular diagnosis. In a two-generation autosomal recessive cerebellar ataxia family, we mapped a linkage to a minimal candidate region on chromosome 16p13.3 flanked by single-nucleotide polymorphism markers rs11248850 and rs1218762. By combining the defined linkage region with the whole-exome sequencing results, we identified a homozygous mutation (c.493CT) in CHIP (NM_005861) in this family. Using Sanger sequencing, we also identified two compound heterozygous mutations (c.389AT/c.441GT; c.621C>G/c.707GC) in CHIP gene in two additional kindreds. These mutations co-segregated exactly with the disease in these families and were not observed in 500 control subjects with matched ancestry. CHIP colocalized with NR2A, a subunit of the N-methyl-D-aspartate receptor, in the cerebellum, pons, medulla oblongata, hippocampus and cerebral cortex. Wild-type, but not disease-associated mutant CHIPs promoted the degradation of NR2A, which may underlie the pathogenesis of ataxia. In conclusion, using a combination of whole-exome sequencing and linkage analysis, we identified CHIP, encoding a U-box containing ubiquitin E3 ligase, as a novel causative gene for autosomal recessive cerebellar ataxia. PMID:24312598

  8. AIPL1 implicated in the pathogenesis of two cases of autosomal recessive retinal degeneration

    PubMed Central

    Li, David; Jin, Chongfei; Jiao, Xiaodong; Li, Lin; Bushra, Tahmina; Naeem, Muhammad Asif; Butt, Nadeem H.; Husnain, Tayyab; Sieving, Paul A.; Riazuddin, Sheikh; Riazuddin, S. Amer

    2014-01-01

    Purpose To localize and identify the gene and mutations causing autosomal recessive retinal dystrophy in two consanguineous Pakistani families. Methods Consanguineous families from Pakistan were ascertained to be affected with autosomal recessive retinal degeneration. All affected individuals underwent thorough ophthalmologic examinations. Blood samples were collected, and genomic DNA was extracted using a salting out procedure. Genotyping was performed using microsatellite markers spaced at approximately 10 cM intervals. Two-point linkage analysis was performed with the lod score method. Direct DNA sequencing of amplified genomic DNA was performed for mutation screening of candidate genes. Results Genome-wide linkage scans yielded a lod score of 3.05 at ?=0 for D17S1832 and 3.82 at ?=0 for D17S938, localizing the disease gene to a 12.22 cM (6.64 Mb) region flanked by D17S1828 and D17S1852 for family 61032 and family 61227, which contains aryl hydrocarbon receptor interacting protein-like 1 (AIPL1), a gene previously implicated in recessive Leber congenital amaurosis and autosomal dominant cone-rod dystrophy. Sequencing of AIPL1 showed a homozygous c.773G>C (p.Arg258Pro) sequence change in all affected individuals of family 61032 and a homozygous c.465G>T (p.(H93_Q155del)) change in all affected members of family 61227. Conclusions The results strongly suggest that the c.773G>C (p.R258P) and c.465G>T (p.(H93_Q155del)) mutations in AIPL1 cause autosomal recessive retinal degeneration in these consanguineous Pakistani families. PMID:24426771

  9. Analysis of pure tar substances (polycyclic aromatic hydrocarbons) in the gas stream using ultraviolet visible (UV-Vis) spectroscopy and multivariate curve resolution (MCR).

    PubMed

    Weide, Tobias; Guschin, Viktor; Becker, Wolfgang; Koelle, Sabine; Maier, Simon; Seidelt, Stephan

    2015-01-01

    The analysis of tar, mostly characterized as polycyclic aromatic hydrocarbons (PAHs), describes a topic that has been researched for years. An online analysis of tar in the gas stream in particular is needed to characterize the tar conversion or formation in the biomass gasification process. The online analysis in the gas is carried out with ultraviolet-visible (UV-Vis) spectroscopy (190-720 nm). This online analysis is performed with a measuring cell developed by the Fraunhofer Institute for Chemical Technology (ICT). To this day, online tar measurements using UV-Vis spectroscopy have not been carried out in detail. Therefore, PAHs are analyzed as follows. The measurements are split into different steps. The first step to prove the online method is to vaporize single tar substances. These experiments show that a qualitative analysis of PAHs in the gas stream with the used measurement setup is possible. Furthermore, it is shown that the method provides very exact results, so that a differentiation of various PAHs is possible. The next step is to vaporize a PAH mixture. This step consists of vaporizing five pure substances almost simultaneously. The interpretation of the resulting data is made using a chemometric interpretation method, the multivariate curve resolution (MCR). The verification of the calculated results is the main aim of this experiment. It has been shown that the tar mixture can be analyzed qualitatively and quantitatively (in arbitrary units) in detail using the MCR. Finally it is the main goal of this paper to show the first steps in the applicability of the UV-Vis spectroscopy and the measurement setup on online tar analysis in view of characterizing the biomass gasification process. Due to that, the gasification plant (at the laboratory scale), developed and constructed by the Fraunhofer ICT, has been used to vaporize these substances. Using this gasification plant for the experiments enables the usage of the measurement setup also for the spectroscopic analysis of the tar formation during the biomass gasification. PMID:25588231

  10. Quantitative analysis of biodiesel in blends of biodiesel and conventional diesel by comprehensive two-dimensional gas chromatography and multivariate curve resolution.

    PubMed

    Mogollon, Noroska Gabriela Salazar; Ribeiro, Fabiana Alves de Lima; Lopez, Monica Mamian; Hantao, Leandro Wang; Poppi, Ronei Jesus; Augusto, Fabio

    2013-09-24

    In this paper, a method to determine the composition of blends of biodiesel with mineral diesel (BXX) by multivariate curve resolution with Alternating Least Squares (MRC-ALS) combined to comprehensive two-dimensional gas chromatography with Flame Ionization Detection (GC×GC-FID) is presented. Chromatographic profiles of BXX blends produced with biodiesels from different sources were used as input data. An initial evaluation carried out after multiway principal component analysis (MPCA) was used to reveal regions of the chromatograms were the signal was likely to be dependent on the concentration of biodiesel, regardless its vegetable source. After this preliminary step MCR-ALS modeling was carried out only using relevant parts of the chromatograms. The resulting procedure was able to predict accurately the concentration of biodiesel in the BXX samples regardless of its origin. PMID:24016593

  11. Analysis of the width-[Formula: see text] non-adjacent form in conjunction with hyperelliptic curve cryptography and with lattices.

    PubMed

    Krenn, Daniel

    2013-06-17

    In this work the number of occurrences of a fixed non-zero digit in the width-[Formula: see text] non-adjacent forms of all elements of a lattice in some region (e.g. a ball) is analysed. As bases, expanding endomorphisms with eigenvalues of the same absolute value are allowed. Applications of the main result are on numeral systems with an algebraic integer as base. Those come from efficient scalar multiplication methods (Frobenius-and-add methods) in hyperelliptic curves cryptography, and the result is needed for analysing the running time of such algorithms. The counting result itself is an asymptotic formula, where its main term coincides with the full block length analysis. In its second order term a periodic fluctuation is exhibited. The proof follows Delange's method. PMID:23805020

  12. A statistical model for the analysis and prediction of the effect of neutron irradiation on Charpy impact energy curves

    Microsoft Academic Search

    P. L. Windle; M. Crowder; R. Moskovic

    1996-01-01

    The structural integrity safety assessments of nuclear reactor pressure vessels are based, in part, on a prediction of the effect of neutron irradiation on material properties. Databases which monitor this effect are often made up of Charpy absorbed energy measurements. This article presents a generally applicable, new and statistically rigorous method of analysis in which any prior belief as to

  13. Micromechanics Micromechanics and Advanced Designs for Curved

    E-print Network

    Rogers, John A.

    Micromechanics Micromechanics and Advanced Designs for Curved Photodetector Arrays in Hemispherical-eye camera with optimized designs based upon micromechanical analysis is reported. The photodetector arrays and deformability, respectively. Quantitative comparison to micromechanics analysis reveals the key features

  14. Buckling of a Longitudinally Jointed Curved Composite Panel Arc Segment for Next Generation of Composite Heavy Lift Launch Vehicles: Verification Testing Analysis

    NASA Technical Reports Server (NTRS)

    Farrokh, Babak; Segal, Kenneth N.; Akkerman, Michael; Glenn, Ronald L.; Rodini, Benjamin T.; Fan, Wei-Ming; Kellas, Sortiris; Pineda, Evan J.

    2014-01-01

    In this work, an all-bonded out-of-autoclave (OoA) curved longitudinal composite joint concept, intended for use in the next generation of composite heavy lift launch vehicles, was evaluated and verified through finite element (FE) analysis, fabrication, testing, and post-test inspection. The joint was used to connect two curved, segmented, honeycomb sandwich panels representative of a Space Launch System (SLS) fairing design. The overall size of the resultant panel was 1.37 m by 0.74 m (54 in by 29 in), of which the joint comprised a 10.2 cm (4 in) wide longitudinal strip at the center. NASTRAN and ABAQUS were used to perform linear and non-linear analyses of the buckling and strength performance of the jointed panel. Geometric non-uniformities (i.e., surface contour imperfections) were measured and incorporated into the FE model and analysis. In addition, a sensitivity study of the specimens end condition showed that bonding face-sheet doublers to the panel's end, coupled with some stress relief features at corner-edges, can significantly reduce the stress concentrations near the load application points. Ultimately, the jointed panel was subjected to a compressive load. Load application was interrupted at the onset of buckling (at 356 kN 80 kips). A post-test non-destructive evaluation (NDE) showed that, as designed, buckling occurred without introducing any damage into the panel or the joint. The jointed panel was further capable of tolerating an impact damage to the same buckling load with no evidence of damage propagation. The OoA cured all-composite joint shows promise as a low mass factory joint for segmented barrels.

  15. Rational Quadratic Approximation to Real Plane Algebraic Curves

    Microsoft Academic Search

    Xiao-shan Gao; Ming Li

    2004-01-01

    An algorithm is proposed to give a global approximation of an implicit real plane algebraic curve with rational quadratic B-spline curves. The algorithm consists of f our steps: topol- ogy determination, curve segmentation, segment approximation and curve tracing. Due to the detailed geometric analysis, high accuracy of approximation may be achieved with a small number of quadratic segments. The final

  16. Development of a high-resolution melting curve analysis screening test for SRSF2 splicing factor gene mutations in myelodysplastic syndromes.

    PubMed

    Garza, Eduardo; Fabiani, Emiliano; Noguera, Nelida; Panetta, Paola; Piredda, Maria L; Borgia, Loredana; Maurillo, Luca; Catalano, Gianfranco; Voso, Maria T; Lo-Coco, Francesco

    2015-01-01

    Somatic mutations of the spliceosome machinery have been recently identified by whole genome analysis in hematologic diseases, such as myelodysplastic syndrome, chronic lymphocytic leukemia, myeloproliferative neoplasms, acute myeloid leukemia, and advanced forms of mastocytosis, and also in nonhematologic conditions. SRSF2 is a member of the serine/arginine-rich family pre-mRNA splicing factors that plays a role in mRNA export from the nucleus and translation. We describe a high-resolution melting (HRM) curve analysis to screen for SRSF2 hotspot mutations in a fast, sensitive, and reliable way. Fifty bone marrow samples from patients with myelodysplastic syndrome were analyzed by the HRM assay and by direct sequencing. HRM screening identified four melting patterns corresponding to a negative (wild-type) group and three different mutated groups. Each mutated group was identified according to the positive control used: P95H, P95L, and P95R, respectively. An HRM mutated pattern was identified in seven patients. Positive and negative results from HRM were compared with direct sequencing results with a sensitivity and specificity of 100% (95% CI, 0.56-1, and 95% CI, 0.89-1, respectively). Analytical sensitivity analysis revealed a detection threshold of up to 1:9 (mutated/wild type) dilution. This rapid screening method may provide useful information for clinical decision making and be helpful to optimize laboratory resources and reduce turnaround time. PMID:25445211

  17. Ecology and Management of the Spring Snowmelt Recession

    NSDL National Science Digital Library

    Sarah Yarnell (University of California, Davis; Center for Watershed Studies)

    2010-02-01

    We present a conceptual model for the ecology of the spring snowmelt recession based on the natural flow regime that relates the quantifiable components of magnitude, timing, and rate of change to abiotic and biotic factors that govern riverine processes. We find that shifts in the magnitude of the recession largely affect abiotic channel conditions, whereas shifts in the timing of the snowmelt primarily affect biotic conditions. Shifts in the rate of change affect both abiotic and biotic conditions, creating the largest observed changes to the stream ecosystem. We discuss these components with regard to the success of riverine species in California's Mediterranean-montane environment. We then present two scenarios of change to the spring snowmelt recessionâ??effects of flow regulation and climate warmingâ??and discuss their potential implications for riverine ecology. Our conceptual model can help guide watershed stakeholders toward a better understanding of the impacts of changing spring recession conditions on stream ecosystems.

  18. The Great Recession and the Risk for Child Maltreatment

    PubMed Central

    Brooks-Gunn, Jeanne; Schneider, William; Waldfogel, Jane

    2013-01-01

    This study draws on the Fragile Families and Child Wellbeing Study (N = 2,032), a birth cohort study of families with children from 20 U.S. cities. Interviews occurred between August 2007, and February 2010, when the children were approximately 9 years old. Macro-economic indicators of the Great Recession such as the Consumer Sentiment Index and unemployment and home foreclosure rates were matched to the data to estimate the links between different measures of the Great Recession and high frequency maternal spanking. We find that the large decline in consumer confidence during the Great Recession, as measured by the Consumer Sentiment Index, was associated with worse parenting behavior. In particular, lower levels of consumer confidence were associated with increased levels of high frequency spanking, a parenting behavior that is associated with greater likelihood of being contacted by child protective services. PMID:24045057

  19. Amnion membrane for coverage of gingival recession: A novel application

    PubMed Central

    Shah, Rucha; Sowmya, N. K.; Mehta, D. S.

    2014-01-01

    Introduction: Amnion allograft has been used in the field of medicine for its exceptional wound-modulating properties. However, in the field of dentistry, only a limited number of reports have explored its potential in healing of oral wounds. Materials and Methods: Amnion allograft in conjunction with coronally advanced flap has been used in the management of gingival recession. Results: A complete coverage along with excellent esthetics and an improvement in gingival biotype was observed at 6 months postoperatively. Discussion: Because of its inherent wound-modulating properties, amnion allograft may be used to enhance periodontal wound healing and enable tissue regeneration such as that in the coverage of gingival recession. Conclusion: Amnion allograft may provide an alternative to other conventional methods of treating gingival recession. PMID:25191061

  20. The Great Recession and the risk for child maltreatment.

    PubMed

    Brooks-Gunn, Jeanne; Schneider, William; Waldfogel, Jane

    2013-10-01

    This study draws on the Fragile Families and Child Wellbeing Study (N=2,032), a birth cohort study of families with children from 20 U.S. cities. Interviews occurred between August 2007, and February 2010, when the children were approximately 9 years old. Macro-economic indicators of the Great Recession such as the Consumer Sentiment Index and unemployment and home foreclosure rates were matched to the data to estimate the links between different measures of the Great Recession and high frequency maternal spanking. We find that the large decline in consumer confidence during the Great Recession, as measured by the Consumer Sentiment Index, was associated with worse parenting behavior. In particular, lower levels of consumer confidence were associated with increased levels of high frequency spanking, a parenting behavior that is associated with greater likelihood of being contacted by child protective services. PMID:24045057

  1. Total fatigue curve

    SciTech Connect

    Sosnovskii, L.A.; Makhutov, N.A. [A.A. Blagonravov Inst. of Machine Engineering, Moscow (Russian Federation)

    1995-11-01

    The fatigue failure mechanisms operative on different segments of the total fatigue curve are discussed. The need for experimental determination of this curve is emphasized; once known, this curve will make possible a deeper insight into the transitional zones associated with a change in the cumulative fatigue damage mechanism.

  2. Congenital Hepatic Fibrosis and Autosomal Recessive Polycystic Kidney Disease

    PubMed Central

    Srinath, Arvind; Shneider, Benjamin L.

    2015-01-01

    Objectives The published natural history of congenital hepatic fibrosis (CHF) was examined to inform clinical decision making in autosomal recessive polycystic kidney disease (ARPKD). Methods A systematic literature search of the data on CHF, ARPKD, Caroli disease, Caroli syndrome, and type V choledochal cyst was performed to extract data related to portal hypertension, infection, malignancy, mortality, and transplantation. Results Information related to 1230 patients with CHF was extracted from 155 articles. Median and mean age at diagnosis were 2 and 11.2 years, respectively. Median and mean time followed after diagnosis were 5.0 and 7.5 years, respectively (range 0–38 years). Sequelae of portal hypertension (n = 409), cholangitis (n = 152), and malignancy (n = 21) were noted. The nature of the portal hypertension was similar to that in other pediatric conditions (164 with varices, 74 bleeding varices, 81 underwent portosystemic shunting). Documented cholangitis was fatal in 3 of 23 children who were infected after renal transplantation. Twenty-one patients developed hepatobiliary cancer, with the majority having cholangiocarcinoma (n = 19). Cholangiocarcinoma (CCA) was predominant in individuals older than 40 years with either Caroli syndrome or isolated CHF, not ARPKD (median and mean age at CCA diagnosis were 70.3 and 60.1 years, respectively; range 33–75 years). There was a relative paucity of data on combined liver-kidney transplantation. Conclusions Clinical decision making in ARPKD should reflect an understanding of the potential issues emanating from CHF. Accepted pediatric specific approaches to portal hypertension are warranted but must take into consideration the stage of renal insufficiency and potential plans for renal transplantation. Cholangitis is a major issue and necessitates anticipatory guidance and awareness. CCA, although a dreaded complication, does not appear to be a major issue during childhood. The indications for liver and combined liver-kidney transplantation are controversial and warrant further analysis. PMID:22197937

  3. A Generalization of Production Decline Type Curves

    Microsoft Academic Search

    G. H. Harrison

    1982-01-01

    The theoretical basis of production decline curve analysis is demonstrated by use of well-established non-empirical well-inflow performance models. Thus it becomes possible to generate a new set of generalized production decline log-log type-curves, of which the one existing in the literature is a subset. The fundamental basis of decline curves is derived directly by use of generalized well-inflow performance expressions.

  4. The prompt-afterglow connection in gamma-ray bursts: a comprehensive statistical analysis of Swift X-ray light curves

    NASA Astrophysics Data System (ADS)

    Margutti, R.; Zaninoni, E.; Bernardini, M. G.; Chincarini, G.; Pasotti, F.; Guidorzi, C.; Angelini, L.; Burrows, D. N.; Capalbi, M.; Evans, P. A.; Gehrels, N.; Kennea, J.; Mangano, V.; Moretti, A.; Nousek, J.; Osborne, J. P.; Page, K. L.; Perri, M.; Racusin, J.; Romano, P.; Sbarufatti, B.; Stafford, S.; Stamatikos, M.

    2013-01-01

    We present a comprehensive statistical analysis of Swift X-ray light curves of gamma-ray bursts (GRBs) collecting data from more than 650 GRBs discovered by Swift and other facilities. The unprecedented sample size allows us to constrain the rest-frame X-ray properties of GRBs from a statistical perspective, with particular reference to intrinsic time-scales and the energetics of the different light-curve phases in a common rest-frame 0.3-30 keV energy band. Temporal variability episodes are also studied and their properties constrained. Two fundamental questions drive this effort: (i) Does the X-ray emission retain any kind of `memory' of the prompt ?-ray phase? (ii) Where is the dividing line between long and short GRB X-ray properties? We show that short GRBs decay faster, are less luminous and less energetic than long GRBs in the X-rays, but are interestingly characterized by similar intrinsic absorption. We furthermore reveal the existence of a number of statistically significant relations that link the X-ray to prompt ?-ray parameters in long GRBs; short GRBs are outliers of the majority of these two-parameter relations. However and more importantly, we report on the existence of a universal three-parameter scaling that links the X-ray and the ?-ray energy to the prompt spectral peak energy of both long and short GRBs: EX, iso?E1.00 ± 0.06?, iso/E0.60 ± 0.10pk.

  5. The Prompt-afterglow Connection in Gamma-ray Bursts: a Comprehensive Statistical Analysis of Swift X-ray Light-curves

    NASA Technical Reports Server (NTRS)

    Margutti, R.; Zaninoni, E.; Bernardini, M. G.; Chincarini, G.; Pasotti, F.; Guidorzi, C.; Angelini, Lorella; Burrows, D. N.; Capalbi, M.; Evans, P. A.; Gehrels, Neil; Kennea, J.; Mangano, V.; Moretti, A.; Nousek, J.; Osborne, J. P.; Page, K. L.; Perri, M.; Racusin, Judith Lea; Romano, P.; Sbarufatti, B.; Stafford, M.; Stamatikos, Michael

    2012-01-01

    We present a comprehensive statistical analysis of Swift X-ray light-curves of Gamma- Ray Bursts (GRBs) collecting data from more than 650 GRBs discovered by Swift and other facilities. The unprecedented sample size allows us to constrain the rest-frame X-ray properties of GRBs from a statistical perspective, with particular reference to intrinsic time scales and the energetics of the different light-curve phases in a common rest-frame 0.3-30 keV energy band. Temporal variability episodes are also studied and their properties constrained. Two fundamental questions drive this effort: i) Does the X-ray emission retain any kind of "memory" of the prompt ?-ray phase? ii) Where is the dividing line between long and short GRB X-ray properties? We show that short GRBs decay faster, are less luminous and less energetic than long GRBs in the X-rays, but are interestingly characterized by similar intrinsic absorption. We furthermore reveal the existence of a number of statistically significant relations that link the X-ray to prompt ?-ray parameters in long GRBs; short GRBs are outliers of the majority of these 2-parameter relations. However and more importantly, we report on the existence of a universal 3-parameter scaling that links the X-ray and the ?-ray energy to the prompt spectral peak energy of both long and short GRBs: E(sub X,iso)? E(sup 1.00+/-0.06)(sub ?,iso) /E(sup 0.60+/-0.10)(sub pk).

  6. Comparative study of Y-split recession versus bilateral medial rectus recession for surgical management of infantile esotropia

    PubMed Central

    Badawi, Nermeen; Hegazy, Khaled

    2014-01-01

    Aim This prospective study compares the results of bilateral medial rectus recession versus (vs) Y-split recession of medial recti techniques for surgical management of essential infantile esotropia. Patients and methods Thirty patients were included in this study and had preoperative infantile esotropia with large angles (ie, >30 prism diopters [PD]). Patients were divided into Group A, which underwent bilateral medial rectus (BMR) recession and Group B, which underwent bilateral Y-split recession of medial recti muscles. All patients were subjected to complete ophthalmologic examination and met the criteria for inclusion in this study. The degrees of BMR recessions performed ranged from 6.0–7.5 mm. All operations were performed under general anesthesia. Follow-up visits were conducted at 1 and 2 weeks, and 1, 3, and 6 months postoperatively. Rates of reoperation for residual esotropia and consecutive exotropia were determined. Results The patients’ preoperative angles of deviation ranged from 30–80 PD. Group A consumed 57% less operative time than Group B. Immediately postoperatively, the Y-splitting technique showed satisfactory results (ie, orthotropic or residual angles ?15 PD) in 73% of patients vs 67% only for the BMR recession patients. By the end of six months of follow up; 13% of the BMR technique patients vs 27% of the Y-splitting technique patients showed negative change of PD but without reoperation. Conclusion Our results suggest that, although the Y-splitting technique is more difficult and time consuming, both procedures are effective and have shown comparable results for the correction of horizontal deviation ?70 PD. PMID:24920880

  7. Social dynamics of health inequalities: a growth curve analysis of aging and self assessed health in the British household panel survey 1991–2001

    PubMed Central

    Sacker, A.; Clarke, P.; Wiggins, R.; Bartley, M.

    2005-01-01

    Objectives: To study how social inequalities change as people age, this paper presents a growth curve model of self assessed health, which accommodates changes in occupational class and individual health with age. Design: Nationally representative interview based longitudinal survey of adults in Great Britain. Setting: Representative members of private households of Great Britain in 1991. Participants: Survey respondents (n = 6705), aged 21–59 years in 1991 and followed up annually until 2001. Main outcome measure: Self assessed health. Results: On average, self assessed health declines slowly from early adulthood to retirement age. No significant class differences in health were observed at age 21. Health inequalities emerged later in life with the gap between mean levels of self assessed health of those in managerial and professional occupations and routine occupations widening approaching retirement. Individual variability in health trajectories increased between ages 40 and 59 years so that this widening of mean differences between occupational classes was not significant. When the analysis is confined to people whose occupational class remained constant over time, a far greater difference in health trajectories between occupational classes was seen. Conclusions: The understanding of social inequalities in health at the population level is enriched by an analysis of individual variation in age related declines by social position. PMID:15911646

  8. On the Perils of Curve-of-Growth Analysis: Systematic Abundance Underestimates for the Gas in Gamma-Ray Burst Host Galaxies

    E-print Network

    Jason X. Prochaska

    2006-06-22

    We examine the practice of deriving interstellar medium (ISM) abundances from low-resolution spectroscopy of GRB afterglows. We argue that the multi-ion single-component curve-of-growth analysis technique systematically underestimates the column densities of the metal-line profiles commonly observed for GRB. This systematic underestimate is accentuated by the fact that many GRB line-profiles (e.g. GRB 050730, GRB 050820, GRB 051111) are comprised of `clouds' with a bi-modal distribution of column density. Such line-profiles may be characteristic of a sightline which penetrates both a high density star-forming region and more distant, ambient ISM material. Our analysis suggests that the majority of abundances reported in the literature are systematically underestimates and that the reported errors are frequently over-optimistic. Further, we demonstrate that one cannot even report precise relative abundances with confidence. The implications are profound for our current understanding on the metallicity, dust-to-gas ratio, and chemical abundances of the ISM in GRB host galaxies. For example, we argue that all but a few sightlines allow for the gas to have at least solar metallicity. Finally, we suggests new approaches for constraining the abundances.

  9. A new X linked recessive deafness syndrome with blindness, dystonia, fractures, and mental deficiency is linked to Xq22.

    PubMed Central

    Tranebjaerg, L; Schwartz, C; Eriksen, H; Andreasson, S; Ponjavic, V; Dahl, A; Stevenson, R E; May, M; Arena, F; Barker, D

    1995-01-01

    X linked recessive deafness accounts for only 1.7% of all childhood deafness. Only a few of the at least 28 different X linked syndromes associated with hearing impairment have been characterised at the molecular level. In 1960, a large Norwegian family was reported with early onset progressive sensorineural deafness, which was indexed in McKusick as DFN-1, McKusick 304700. No associated symptoms were described at that time. This family has been restudied clinically. Extensive neurological, neurophysiological, neuroradiological, and biochemical, as well as molecular techniques, have been applied to characterise the X linked recessive syndrome. The family history and extensive characterisation of 16 affected males in five generations confirmed the X linked recessive inheritance and the postlingual progressive nature of the sensorineural deafness. Some obligate carrier females showed signs of minor neuropathy and mild hearing impairment. Restudy of the original DFN-1 family showed that the deafness is part of a progressive X linked recessive syndrome, which includes visual disability leading to cortical blindness, dystonia, fractures, and mental deficiency. Linkage analysis indicated that the gene was linked to locus DXS101 in Xq22 with a lod score of 5.37 (zero recombination). Based on lod-1 support interval of the multipoint analysis, the gene is located in a region spanning from 5 cM proximal to 3 cM distal to this locus. As the proteolipid protein gene (PLP) is within this region and mutations have been shown to be associated with non-classical PMD (Pelizaeus-Merzbacher disease), such as complex X linked hereditary spastic paraplegia, PLP may represent a candidate gene for this disorder. This family represents a new syndrome (Mohr-Tranebjaerg syndrome, MTS) and provides significant new information about a new X linked recessive sydromic type of deafness which was previously thought to be isolated deafness. PMID:7643352

  10. Age differences in verbal and visuo-spatial working memory updating: evidence from analysis of serial position curves.

    PubMed

    Fiore, Felicia; Borella, Erika; Mammarella, Irene C; De Beni, Rossana

    2012-01-01

    Memory updating is the ability to select and update relevant information and suppress no-longer-relevant data. The few studies in this area, targeting mainly the verbal domain, have investigated and confirmed an age-related decline in working memory updating ability (De Beni & Palladino, 2004; Van der Linden, Bredart, & Beerten, 1994). The present research examines the ability of younger and older adults to update information in verbal and visuo-spatial running memory tasks. Results showed that the participants' performance was higher in the verbal than in the visuo-spatial task. Nonetheless, independently of the task domain, an age-related decline in updating performance was found. Moreover, analysis of serial positions suggested that, in the updating procedure, the participants were not attempting to actively maintain items, preferring to adopt a low-effort, "recency-based" strategy. The use of this type of strategy is more evident in older participants, as shown in both the accuracy performance and the proportion of intrusion errors. PMID:22133192

  11. Surface Water Ground Water Interaction Inferred from Discharge vs. Basin Area Curves

    NASA Astrophysics Data System (ADS)

    Biswal, B.; D, N.

    2012-12-01

    Peak discharge (Qp) vs. basin area (A) curves have been studied for long time leading to the development of some of the promising hydrological response models. In this study we also analyze discharge vs. basin area curves for recession periods. We define the characteristic discharge, Qn, as the discharge observed in the n-th day after a peak, then for each value of n we analyze Qn vs. A curves, which typically follow a power law equation of type: Qp ? A?n. The exponent ? n for n=0 is known to take value between 0.5 and 1 (note that Qn = Qp for n=0), and the commonly accepted theoretical explanation for it is that Qp is controlled by width of channel network and effective rainfall duration. This premise is based on the assumption that surface flow dominates during a flood event in a basin and that flow velocity is constant everywhere in the stream network of the basin. As n increases, i.e. during recession periods, Qn is expected to be controlled by subsurface flow. According to the geomorphological recession flow model Qn for higher values of n is controlled by the dynamics of saturated channel network, and for this case the value of ? n is close to 1. Results here show that ? n increases and approaches 1 as n increases, confirming the notion that a transition from surface water dominated flow process to subsurface water dominated flow process occurs with time during a recession event.

  12. New recessive syndrome of microcephaly, cerebellar hypoplasia, and congenital heart conduction defect.

    PubMed

    Zaki, Maha S; Salam, Ghada M H Abdel; Saleem, Sahar N; Dobyns, William B; Issa, Mahmoud Y; Sattar, Shifteh; Gleeson, Joseph G

    2011-12-01

    We identified a two-branch consanguineous family in which four affected members (three females and one male) presented with constitutive growth delay, severe psychomotor retardation, microcephaly, cerebellar hypoplasia, and second-degree heart block. They also shared distinct facial features and similar appearance of their hands and feet. Childhood-onset insulin-dependent diabetes mellitus developed in one affected child around the age of 9 years. Molecular analysis excluded mutations in potentially related genes such as PTF1A, EIF2AK3, EOMES, and WDR62. This condition appears to be unique of other known conditions, suggesting a unique clinical entity of autosomal recessive mode of inheritance. PMID:22002884

  13. Relative Locality in Curved Spacetime

    NASA Astrophysics Data System (ADS)

    Kowalski-Glikman, Jerzy; Rosati, Giacomo

    2013-07-01

    In this paper we construct the action describing dynamics of the particle moving in curved spacetime, with a nontrivial momentum space geometry. Curved momentum space is the core feature of theories where relative locality effects are present. So far aspects of nonlinearities in momentum space have been studied only for flat or constantly expanding (de Sitter) spacetimes, relying on their maximally symmetric nature. The extension of curved momentum space frameworks to arbitrary spacetime geometries could be relevant for the opportunities to test Planck-scale curvature/deformation of particles momentum space. As a first example of this construction we describe the particle with ?-Poincaré momentum space on a circular orbit in Schwarzschild spacetime, where the contributes of momentum space curvature turn out to be negligible. The analysis of this problem relies crucially on the solution of the soccer ball problem.

  14. INTRODUCTION Usher syndrome (USH) is characterized by recessively inherited

    E-print Network

    Westerfield, Monte

    INTRODUCTION Usher syndrome (USH) is characterized by recessively inherited deaf in USH2 and USH3, but there is currently no treatment to counter the vision loss resulting from retinitis pigmentosa. Early diagnosis is important for genetic counseling and preparation for late-onset blindness

  15. Tag, Catch, and Other Unnatural Acts at Recess (Circa 2014)

    ERIC Educational Resources Information Center

    Sydnor, Synthia

    2014-01-01

    This commentary details a news event in which Carrie Weber Middle School in Port Washington, NY, supposedly banned students from using balls, playing tag, and doing cartwheels during recess. Public reaction in the form of news items, tweets, blogs, and commentary is sampled, and news releases from the Weber Middle School that were barely covered…

  16. Intrinsically Motivated, Free-Time Physical Activity: Considerations for Recess

    ERIC Educational Resources Information Center

    Stellino, Megan Babkes; Sinclair, Christina D.

    2008-01-01

    The current childhood obesity rates raise concern about youths' health and the role that a sedentary lifestyle plays in this growing trend. Focusing on how children choose to spend their free time is one approach that may yield ideas for reducing childhood obesity. Recess is a regularly occurring "free time" period in elementary schools. It is,…

  17. Thymidine Phosphorylase Deficiency Causes MNGIE: An Autosomal Recessive Mitochondrial Disorder

    Microsoft Academic Search

    M. Hirano; R. Martí; A. Spinazzola; I. Nishino; Y. Nishigaki

    2004-01-01

    Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) is an autosomal recessive disorder caused by mutations in the gene encoding thymidine phosphorylase (TP). The disease is characterized clinically by impaired eye movements, gastrointestinal dysmotility, cachexia, peripheral neuropathy, myopathy, and leukoencephalopathy. Molecular genetic studies of MNGIE patients' tissues have revealed multiple deletions, depletion, and site?specific point mutations of mitochondrial DNA. TP is a cytosolic enzyme

  18. Applications to One Business School Skyrocketed Despite Recession

    ERIC Educational Resources Information Center

    Tao, Sharon

    2010-01-01

    In the past two years, the global financial crisis has wreaked havoc on businesses in America and abroad. But the gloom and doom seems to have had the opposite effect on business schools. The reason is that a recession often signals the perfect time for proactive students to sharpen their skill sets, shift their career goals (whether toward a…

  19. The Post-Recession Employment Situation: A Comparative Perspective

    ERIC Educational Resources Information Center

    Couch, Kenneth A.

    2012-01-01

    Slow economic growth since the end of the U.S. recession in June of 2009 has not yet translated into increases in employment large enough to meaningfully reduce the rate of unemployment. Because expansionary macroeconomic policy has been pursued on both the fiscal and monetary fronts, it appears at first glance that the hands of government at this…

  20. Exterior building details of Building A; east façade: recessed panel ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Exterior building details of Building A; east façade: recessed panel inscribed "1859", historic window opening with concrete sill above door, cement plaster dentil course and cornice, truncated wood beam ends, plaster finished brick wall, granite base; westerly view - San Quentin State Prison, Building 22, Point San Quentin, San Quentin, Marin County, CA