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Recession slope curve analysis under human interferences  

NASA Astrophysics Data System (ADS)

To study the base flow recession at the watershed scale, the log-scale plot of - dQ/ dt ˜ Q proposed by Brutsaert and Nieber [10] has been used to estimate the recession parameters, i.e., the slope and interception of the theoretical recession slope curve. The lower envelope or the best fit in some studies is usually used to determine the recession slope curve for natural watersheds. However, human interferences exist in most watersheds around the world. This paper discusses the impact of human interferences, which include groundwater pumping, water diversion and return flow, on the determination of the recession slope curve and the cloud shape of the data points of - dQ/ dt ˜ Q. First, values of - dQ/ dt generated for hypothetical watersheds are analyzed. Then real data for three watersheds in Illinois is analyzed to verify the hypothetical analysis. The placement of the recession slope curve depends on the coexistence and relative amount of the evapotranspiration, groundwater pumping or even water diversion if it exists, and the return flow. When the water consumption rate is small, the recession slope curve can even be located at the upper envelope of the cloud of points representing historical data. These results suggest that the use of the lower envelope as a guideline for estimating recession parameters for watersheds subject to human interferences can result in biased estimates.

Wang, Dingbao; Cai, Ximing



A visual basic spreadsheet macro for recession curve analysis.  


A Visual Basic program for an Excel spreadsheet was written to construct a master recession curve (MRC), using the adapted matching strip method, for recession analysis of ground water level time series. The program uses five different linear/nonlinear regression models to adjust individual recession segments to their proper positions in the MRC. The program can also be used to analyze the recession segments of other time series, such as daily stream discharge or stage. Some examples of field data from Croatia are used to illustrate the usefulness of its application. PMID:16961500

Posavec, Kristijan; Bacani, Andrea; Naki?, Zoran


Comparative analysis of base flow recession curves for different Andean catchments  

NASA Astrophysics Data System (ADS)

Little is known in the Paute River basin, Ecuador about the groundwater resources, the relation between aquifers and their recharge zones and interaction with rivers. The pressure from human activities in the river basin is increasing and impacting the surface water quality and quantity, therefore it becomes increasingly useful to estimate the potential of groundwater exploitation as an alternative resource. Due to the lack of specific groundwater data and information, assessment of suitable alternative methods for groundwater research at different scales is considered. In low flow hydrology literature it is noted that the majority of natural gains to streamflow during low-flow periods are derived from releases from groundwater storage, moreover baseflow is generally suggested to be an indicator of groundwater or other delayed sources. Analysis of flow recession curves allows the determination of characteristics of the groundwater reservoir, which is a prerequisite for the separation of baseflow from total discharge and the estimation of groundwater storage and recharge. The flow recession curve at a river cross section is defined as the discharge hydrograph of the basin during a rainless or dry period. Its analysis yields information on the retention characteristics of the basin and of groundwater storage and depletion. In the Paute River basin baseflows are assumed to be originating from Paramo storage, which is largely determined by the high water retention capacity of the soils in combination with their slopes. In the case of the sub-catchment of the Tarqui River, there are evidences based on topography, hydromorphology, discharges and soils that suggest the presence of a major aquifer in the valley. Hence, the goal of this contribution is the comparison and analysis of groundwater conditions based on baseflow recession analysis for the Tarqui and Yanuncay River sub-catchments. Baseflow analyses are translated in recharge and groundwater resources characteristics, as well as relationships with land cover, morphology, geology and rainfall are established and presented. The results are discussed within the framework of increasing pressures on the water system.

Guzman, P.; Batelaan, O.; Wyseure, G.



Recession curve estimation for storm event separations  

Microsoft Academic Search

An accurate recession curve model is important for separating individual flow events, which is especially difficult over catchments in regions with a maritime climate where frequent rainfall events cause the flows to rise before they reach the baseflow level. The traditional recession curve equations are based on static linear and nonlinear reservoir models. These models work quite well for ground

M. Hammond; D. Han



An improved method for delineating source protection zones for karst springs based on analysis of recession curve data  

NASA Astrophysics Data System (ADS)

A standard method for delineating source protection zones, particularly for karst and carbonate springs, has been improved. The method, based on recession curve analysis, defines four vulnerability scenarios with an evaluation of the appropriate dimensions of the protection areas, accommodating situations where field-test data are not available. The new approach makes it easier to separate the components of the spring discharge hydrograph. The objective is to achieve simplification, and an effective, more rigorous, procedure in the determination of the parameters used by Mangin’s model—Mangin A (1975) Contribution a l’étude hydrodynamique des aquifères karstiques-Troisieme partie: Constitution et fonctionnement des aquifères karstiques (Contribution to the hydrodynamic study of karst aquifers, part 3: formation and work of karst aquifers). Ann Speleol 30(1):21 124. The original procedure, plus the lack of sufficient data, was open to subjective interpretation. With the aid of modern technology, a very large quantity of data is now available and it is necessary to process it using denoise type computer-based filters before passing to interpretation. Working with discharge data series, a statistical approach is proposed to give an analytical solution for determining the values of fundamental parameters of the recession curve model. The new procedure is defined and compared with the original methodology. The new approach has been tested and applied to a number of karst springs in Italy. A case history for a spring located in the Piedmont region of the Maritime Alps, is presented. The proposed new procedure can be utilised to mark the limits of the protection zones of tapped groundwater supplied for potable use, as required by European and local legislation.

Civita, Massimo V.



Baseflow Recession Analysis for Comparison of Drainage Basins and Geology  

Microsoft Academic Search

By means of baseflow recession analysis a method of comparing drainage basins and geologic formations with the aquifers at, maximum performance has been developed. With the technique it is possible to analyze data for perennial and intermittent streams. A minimum of subjective judgments is involved, so that comparable results can be obtained from inde- lendent investigations. The baseflow recession curve

Walter G. Knisel



A new dose-response curve for bilateral medial rectus recessions for infantile esotropia  

Microsoft Academic Search

Purpose: In 1982, Mims et al1 generated the first rigorous dose-response curve for bilateral medial rectus recessions for infantile esotropia (ET). Curve fitting calculations were hampered by substantial variability of surgical effect for the larger angles of ET, and an exponential curve was chosen for angles below 30 ET and a straight line for angles above 30 ET. In a

Huy M. Tran; James L. Mims; Robert C. Wood



Fully automated objective-based method for master recession curve separation.  


The fully automated objective-based method for master recession curve (MRC) separation was developed by using Microsoft Excel spreadsheet and Visual Basic for Applications (VBA) code. The core of the program code is used to construct an MRC by using the adapted matching strip method (Posavec et al. 2006). Criteria for separating the MRC into two or three segments are determined from the flow-duration curve and are represented as the probable range of percent of flow rate duration. Successive separations are performed automatically on two and three MRCs using sets of percent of flow rate duration from selected ranges and an optimal separation model scenario, having the highest average coefficient of determination R(2), is selected as the most appropriate one. The resulting separated master recession curves are presented graphically, whereas the statistics are presented numerically, all in separate sheets. Examples of field data obtained from two springs in Istria, Croatia, are used to illustrate its application. The freely available Excel spreadsheet and VBA program ensures the ease of use and applicability for larger data sets. PMID:20100291

Posavec, Kristijan; Parlov, Jelena; Naki?, Zoran



Multiscale Transfer Printing into Recessed Microwells and on Curved Surfaces via Hierarchical Perfluoropolyether Stamps.  


A simple method for the formation of multiscale metal patterns is presented using hierarchical polymeric stamps with perfluoropolyether (PFPE). A dual-scale PFPE structure is made via two-step moulding process under partial photocrosslinking conditions. The hierarchical PFPE stamp enables multiscale transfer printing (MTP) of metal pattern in one step within microwells as well as on curved surfaces. PMID:23606663

Park, Hyunchul; Cho, Hyesung; Kim, Junsoo; Bang, Jung Won; Seo, Soonmin; Rahmawan, Yudi; Lee, Deuk Yeon; Suh, Kahp-Yang



Peak flow rate and recession-curve characteristics of a karst spring in the Inner Bluegrass, central Kentucky  

USGS Publications Warehouse

The flow rate at the terminal spring of a 1929 ha karst ground-water catchment has been continuously monitored for 2 years, and 108 identifiable events were analyzed. The peak flow rates followed a beta frequency distribution with parameters ?? = 0.365 and ?? = 1.135. Events were separated into high-flow and low-flow. High-flow events had characteristics attributable to pipe flow. Correlation and stepwise regression were used to develop peak flow rate prediction equations for the combined 108 events and for the 81 low-flow events. The portion of the recession curve identified as pipe flow was a watershed constant and time invariant. The base flow was seasonal, increasing in the winter to approximately 0.071 m3s-1 and decreasing in the summer to approximately 0.014 m3s-1. ?? 1994.

Felton, G. K.; Currens, J. C.



Recession flow analysis of the Blue Nile River  

Microsoft Academic Search

Estimates of the amount of recession flow can be derived from streamflow records. Such estimates are critical in the assessment of low flow characteristics for the Blue Nile River, from which about two-thirds of the irrigation requirements in Sudan are satisfied. The recession flow hydrograph can be estimated by fitting the conceptual non-linear storage outflow model using an iterative algorithm.

Anil Mishra; Takeshi Hata; A. W. Abdelhadi; Akio Tada; Haruya Tanakamaru



Estimating parental relationship in linkage analysis of recessive traits  

SciTech Connect

In linkage analysis of recessive traits, parental relationship is important. For the case that it is unknown, the question is investigated as to whether estimating parental relationship and using the estimated relationship in linkage analysis is beneficial. Results show that estimating parental relationship can reliably be carried out on the basis of 50-100 genetic marker loci (analysis based on theory by Thompson). Misspecification of parental relationship leads to a loss of linkage informativeness, but not to false-positive evidence for linkage. An asymptotic bias in the recombination fraction estimate occurs when parents are unrelated and falsely taken to be related, but no such bias is seen when related parents are taken to be unrelated. Results from this investigation suggest that an estimated parental relationship may be used in linkage analysis as if it were the correct relationship, when evidence for the estimated relationship is supported by a likelihood ratio of at least 10:1 against the parents being unrelated. 9 refs., 2 figs., 5 tabs.

Merette, C. [Universite Laval Robert-Giffard, Beauport, Quebec (Canada); Ott, J. [Columbia Univ., New York, NY (United States)



Gross Worker Flows in the United Kingdom: An Anatomical Analysis of the 2008-2009 Recession  

Microsoft Academic Search

This paper provides a detailed analysis of the gross worker flows data in the United Kingdom between 1997 and 2010, with particular emphasis on the 2008-2009 recession and its aftermath. Utilising flows data from the Labour Force Survey, the dominant macroeconomic factors driving unemployment in the United Kingdom before, during, and after the recession period are identified. Amongst the salient

Andrew Sutton


Recession analysis of the Hupselse Beek catchment, The Netherlands  

NASA Astrophysics Data System (ADS)

Many parametric hydrological models use one or more linear reservoirs as model components. However, linear reservoirs may not be ideal to represent the real, nonlinear hydrologic behavior of a catchment. The reservoir coefficients of catchments can be obtained from discharge data with a method suggested by Brutsaert and Nieber (1977). From dry weather recession curves in hydrographs, the negative of the discharge changes over time were extracted and plotted against the discharge in a double logarithmic graph. The slope of the lower envelope around the separate points corresponds with the exponent of the reservoir (one for linear reservoirs). Kirchner (in press) adapted this method and fitted a regression line through the means of the points to determine reservoir coefficients for the Plynlimon catchment. The obtained reservoir coefficients were implemented in a simple model based on an integration of the nonlinear storage - discharge relation to reconstruct the streamflow hydrograph In this research project Kirchner's method is used to determine the reservoir coefficients and run the model for the Hupselse Beek catchment in the Netherlands. Hourly discharge, precipitation and evapotranspiration data for the period May 1979 - March 1987 have been used for this purpose. Compared to the Plynlimon catchment, our study catchment is much less humid and soil physical processes such as capillary rise play a more important role. The results show that the reservoir exponent is larger than one, which implies that the behavior of the catchment is nonlinear. The reservoir coefficients obtained for summer periods differ from those obtained for winter periods. Another result is that streamflow in the Hupselse Beek catchment cannot be reconstructed completely with the simple model described above. Winter discharges can often be modeled quite well, but the model fails in simulating summer periods or dry spells. When evapotranspiration rates exceed modeled storage volume plus precipitation, negative discharges are produced and the model collapses. A quick fix could be to introduce a fixed lower limit to avoid negative discharges. However, it does not yield satisfactory results either. This suggests that additional hydrological processes (eg. a soil moisture reservoir and capillary rise) should be included in the parameterization in order to obtain plausible model results for the study catchment. Brutsaert, W. and J. L. Nieber, Regionalized drought flow hydrographs from a mature glaciated plateau, Water Resources Research, 13, 637-643, 1977 Kirchner, J.W., Catchments as simple dynamical systems: catchment characterization, rainfall-runoff modeling, and doing hydrology backwards, Water Resources Research, in press

Brauer, C. C.; Stricker, J. N. M.; Warmerdam, P. M. M.; Uijlenhoet, R.



Comparative analysis between analytical approximations and numerical solutions describing recession flow in unconfined hillslope aquifers  

Microsoft Academic Search

Recession flow of aquifers from a hillslope can be described by the non-linear Boussinesq equation. Under strong assumptions\\u000a and for specific conceptual formulations, different authors derived analytical approximations or linearized versions to this\\u000a partial differential equation. A comparative analysis between some analytical approximations of the Boussinesq equation and\\u000a the numerical solution of the recession flow of an unconfined homogeneous aquifer

David Rocha; Jan Feyen; Alain Dassargues



Evaluating the effect of partial contributing storage on storage-discharge function from recession analysis  

NASA Astrophysics Data System (ADS)

Hydrograph recession during dry periods has been used to construct water storage-discharge relationship, and to quantify storage dynamics and evaporation when streamflow data is available. However, variable hydrologic connectivity among hillslope-riparian-stream zones may affect the lumped storage-discharge relationship, and as a result, affect the estimation of evaporation and storage change. Given observations of rainfall and runoff, and remote sensing-based observation of evaporation, the ratio (?) between estimated daily evaporation from recession analysis and observed evaporation, and the ratio (?) between estimated contributing storage and total watershed storage are computed for 9 watersheds located in different climate regions. Both evaporation and storage change estimation from recession analysis are underestimated due to the effect of partial contributing storage, particularly when the discharge is low. It was found that the values of ? decrease significantly during individual recession events, while the values of ? are relatively stable during a recession event. The values of ? are negatively correlated with the water table depth, and vary significantly among recession events. The partial contributing storage effect is one possible cause for the multi-valued storage-discharge relationship.

Chen, X.; Wang, D.



Nonparametric Regression Analysis of Growth Curves  

Microsoft Academic Search

In recent years, nonparametric curve estimates have been extensively explored in theoretical work. There has, however, been a certain lack of convincing applications, in particular involving comparisons with parametric techniques. The present investigation deals with the analysis of human height growth, where longitudinal measurements were collected for a sample of boys and a sample of girls. Evidence is presented that

Theo Gasser; Hans-Georg Muller; Walter Kohler; Luciano Molinari; Andrea Prader



Stress analysis for spherically curved glass reflectors  

SciTech Connect

An analysis is given of the stresses that occur in elastically deformed, spherically curved glass mirrors for solar energy applications. Forming stresses, residual stresses, spring back deformation, and thermal stresses are analyzed. In addition, fracture mechanics and stress corrosion are discussed. Results are presented in generalized form for use in new designs.

Steele, C.R.; Stephanou, N.; Steele, M.; Nelson, D.



Key curve analysis of crack-growth-resistance curves  

Microsoft Academic Search

A previously suggested relation among load, displacement, and remaining-ligament for stable crack growth was validated by examining literature data on three-point-bend and compact specimens. The resulting key curves were found to consist of one or more power-law segments, with the major portion of growth generally confined to one of the segments. The J-integral was then expressed in terms of the

I.-H. Lin



Strategy for mutation analysis in the autosomal recessive limb-girdle muscular dystrophies  

Microsoft Academic Search

We describe a strategy for molecular diagnosis in the autosomal recessive limb-girdle muscular dystrophies, a highly heterogeneous group of inherited muscle-wasting diseases. Genetic mutation analysis is directed by immunoanalysis of muscle biopsies using antibodies against a panel of muscular dystrophy-associated proteins. Performing the molecular analysis in this way greatly increases the chance that mutations will be found in the first

Robert Pogue; Louise V. B Anderson; Angela Pyle; Caroline Sewry; Christine Pollitt; Margaret A Johnson; Keith Davison; Jennifer A Moss; Eugenio Mercuri; Francesco Muntoni; Katherine M. D Bushby



Incorporating Experience Curves in Appliance Standards Analysis  

SciTech Connect

The technical analyses in support of U.S. energy conservation standards for residential appliances and commercial equipment have typically assumed that manufacturing costs and retail prices remain constant during the projected 30-year analysis period. There is, however, considerable evidence that this assumption does not reflect real market prices. Costs and prices generally fall in relation to cumulative production, a phenomenon known as experience and modeled by a fairly robust empirical experience curve. Using price data from the Bureau of Labor Statistics, and shipment data obtained as part of the standards analysis process, we present U.S. experience curves for room air conditioners, clothes dryers, central air conditioners, furnaces, and refrigerators and freezers. These allow us to develop more representative appliance price projections than the assumption-based approach of constant prices. These experience curves were incorporated into recent energy conservation standards for these products. The impact on the national modeling can be significant, often increasing the net present value of potential standard levels in the analysis. In some cases a previously cost-negative potential standard level demonstrates a benefit when incorporating experience. These results imply that past energy conservation standards analyses may have undervalued the economic benefits of potential standard levels.

Garbesi, Karina; Chan, Peter; Greenblatt, Jeffery; Kantner, Colleen; Lekov, Alex; Meyers, Stephen; Rosenquist, Gregory; Buskirk, Robert Van; Yang, Hung-Chia; Desroches, Louis-Benoit



What Is a Recessive Allele?  

ERIC Educational Resources Information Center

|Presents four misconceptions students have concerning the concepts of recessive and dominant alleles. Discusses the spectrum of dominant-recessive relationships, different levels of analysis between phenotype and genotype, possible causes of dominance, and an example involving wrinkled peas. (MDH)|

American Biology Teacher, 1991



Rapid multipoint linkage analysis of recessive traits in nuclear families, including homozygosity mapping  

SciTech Connect

Homozygosity mapping is a powerful strategy for mapping rare recessive traits in children of consanguineous marriages. Practical applications of this strategy are currently limited by the inability of conventional linkage analysis software to compute, in reasonable time, multipoint LOD scores for pedigrees with inbreeding loops. We have developed a new algorithm for rapid multipoint likelihood calculations in small pedigrees, including those with inbreeding loops. The running time of the algorithm grows, at most, linearly with the number of loci considered simultaneously. The running time is not sensitive to the presence of inbreeding loops, missing genotype information, and highly polymorphic loci. We have incorporated this algorithm into a software package, MAPMAKER/HOMOZ, that allows very rapid multipoint mapping of disease genes in nuclear families, including homozygosity mapping. Multipoint analysis with dozens of markers can be carried out in minutes on a personal workstation. 23 refs., 4 figs., 1 tab.

Kruglyak, L.; Daly, M.J. [Whitehead Institute for Biomedical Research, Cambridge, MA (United States); Lander, E.S. [Whitehead Institute for Biomedical Research, Cambridge, MA (United States)]|[Massachusetts Institute of Technology, Cambridge, MA (United States)



Genetic analysis of TMPRSS3 gene in the Korean population with autosomal recessive nonsyndromic hearing loss.  


The TMPRSS3 gene (DFNB8/10), which encodes a transmembrane serine protease, is a common hearing loss gene in several populations. Accurate functions of TMPRSS3 in the hearing pathway are still unknown, but TMPRSS3 has been reported to play a crucial role in inner ear development or maintenance. To date, 16 pathogenic mutations have been identified in many countries, but no mutational studies of the TMPRSS3 gene have been conducted in the Korean hearing loss population. In this study, we performed genetic analysis of TMPRSS3 in 40 unrelated Korean patients with autosomal recessive hearing loss to identify the aspect and frequency of TMPRSS3 gene mutations in the Korean population. A total of 22 variations were detected, including a novel variant (p.V291L) and a previously reported pathogenic mutation (p.A306T). The p.A306T mutation which has been detected in only compound heterozygous state in previous studies was identified in homozygous state for the first time in this study. Moreover, the clinical evaluation identified bilateral dilated vestibules in the patient with p.A306T mutation, and it suggested that p.A306T mutation of the TMPRSS3 gene might be associated with vestibular anomalies. In conclusion, this study investigated that only 2.5% of patients with autosomal recessive hearing loss were related to TMPRSS3 mutations suggesting low prevalence of TMPRSS3 gene in Korean hearing loss population. Also, it will provide the information of genotype-phenotype correlation to understand definite role of TMPRSS3 in the auditory system. PMID:23958653

Lee, Jinwook; Baek, Jeong-In; Choi, Jae Young; Kim, Un-Kyung; Lee, Sang-Heun; Lee, Kyu-Yup



Molecular and phenotypic analysis of 25 recessive, homozygous-viable alleles at the mouse agouti locus.  

PubMed Central

Agouti is a paracrine-acting, transient antagonist of melanocortin 1 receptors that specifies the subapical band of yellow on otherwise black hairs of the wild-type coat. To better understand both agouti structure/function and the germline damage caused by chemicals and radiation, an allelic series of 25 recessive, homozygous-viable agouti mutations generated in specific-locus tests were characterized. Visual inspection of fur, augmented by quantifiable chemical analysis of hair melanins, suggested four phenotypic categories (mild, moderate, umbrous-like, severe) for the 18 hypomorphs and a single category for the 7 amorphs (null). Molecular analysis indicated protein-coding alterations in 8 hypomorphs and 6 amorphs, with mild-moderate phenotypes correlating with signal peptide or basic domain mutations, and more devastating phenotypes resulting from C-terminal lesions. Ten hypomorphs and one null demonstrated wild-type coding potential, suggesting that they contain mutations elsewhere in the > or = 125-kb agouti locus that either reduce the level or alter the temporal/spatial distribution of agouti transcripts. Beyond the notable contributions to the field of mouse germ cell mutagenesis, analysis of this allelic series illustrates that complete abrogation of agouti function in vivo occurs most often through protein-coding lesions, whereas partial loss of function occurs slightly more frequently at the level of gene expression control.

Miltenberger, Rosalynn J; Wakamatsu, Kazumasa; Ito, Shosuke; Woychik, Richard P; Russell, Liane B; Michaud, Edward J



Decline curve derivative analysis for homogeneous and composite reservoirs  

SciTech Connect

In this study, the rate decline and rate decline derivatives of a constant pressure well are presented for infinite, constant pressure outer boundary, and closed outer boundary homogeneous reservoirs. A rate derivative type curve is provided for these cases as well. The effects of the dimensionless reservoir exterior radius are discussed. Rate decline and rate decline derivatives of a constant pressure well in an infinite composite reservoir are also presented. For composite reservoirs, the effects of mobility ratios and discontinuity distance on both rate decline and rate decline derivatives are presented. Type curves for dimensionless wellbore flow rate derivatives for infinite composite reservoirs are provided. A new correlating group for the derivative type curve is provided, and is different than the correlating group for the rate type curve presented in the past. Finally, an analysis method that comprises type curve and derivative type curve matching to determine the dimensionless variables is proposed and demonstrated with a simulated example.

Demski, J.A.



SITAR--a useful instrument for growth curve analysis  

PubMed Central

Background Growth curve analysis is a statistical issue in life course epidemiology. Height in puberty involves a growth spurt, the timing and intensity of which varies between individuals. Such data can be summarized with individual Preece–Baines (PB) curves, and their five parameters then related to earlier exposures or later outcomes. But it involves fitting many curves. Methods We present an alternative SuperImposition by Translation And Rotation (SITAR) model, a shape invariant model with a single fitted curve. Curves for individuals are matched to the mean curve by shifting their curve up–down (representing differences in mean size) and left–right (for differences in growth tempo), and the age scale is also shrunk or stretched to indicate how fast time passes in the individual (i.e. velocity). These three parameters per individual are estimated as random effects while fitting the curve. The outcome is a mean curve plus triplets of parameters per individual (size, tempo and velocity) that summarize the individual growth patterns. The data are heights for Christ’s Hospital School (CHS) boys aged 9–19 years (N?=?3245, n?=?129?508), and girls with Turner syndrome (TS) aged 9–18 years from the UK Turner Study (N?=?105, n?=?1321). Results The SITAR model explained 99% of the variance in both datasets [residual standard deviation (RSD) 6–7?mm], matching the fit of individually-fitted PB curves. In CHS, growth tempo was associated with insulin-like growth factor-1 measured 50 years later (P?=?0.01, N?=?1009). For the girls with TS randomized to receive oxandrolone from 9 years, velocity was substantially increased compared with placebo (P?=?10?8). Conclusions The SITAR growth curve model is a useful epidemiological instrument for the analysis of height in puberty.

Cole, Tim J; Donaldson, Malcolm D C; Ben-Shlomo, Yoav



Genetic analysis of loci that contribute to recessive polycystic kidney disease in the mouse  

SciTech Connect

Identification of genes that play a role in the development of autosomal recessive polycystic kidney disease (ARPKD) is a key to the better understanding of this disorder. We have discovered a new mutation in the mouse we call juvenile cystic kidney (jck) which predisposes to the development of ARPKD and is not allelic with any previously described mutations. In an effort to map and positionally clone the jck gene, an intraspecific intercross between B6/DBA jck/+F1 mice was established and over 100 affected progeny were identified. Genotype analysis using microsatellite markers was employed and the jck mutation has been mapped to a 1 cM interval on mouse chromosome 11. Positional cloning of this mutant locus by employing a YAC contig is in progress. Narrowing the region of interest has been facilitated by the utilization of SSCP analysis to develop informative markers from YAC sequence. In addition, it was noted that severity of disease in the intercross progeny (as measured by the degree of kidney enlargement) was more variable than that observed in the parental B6 strain. This suggested that a modifier locus introduced form the DBA background affects the expression of the jck phenotype. We have determined that two additional regions - one from DBA on distal chromosome 10 and a second from B6 on chromosome 1 - are strongly associated with inheritance of a more severe polycystic kidney disease phenotype. The finding of a highly significant association of a B6-related locus with kidney enlargement was completely unexpected, since the PKD phenotype in the original B6 background is not severe. This finding is unambiguous, with a maximal quantitative trait locus (QTL) analysis LOD score of 15 for association with disease severity. We propose that it is the inheritance of both a homozygous B6 locus on chromosome 1 and a DBA gene that results in the severe phenotype, presumably as a consequence of an interaction between their protein products.

Beier, D.R.; Dushkin, H.; Tobin, D. [Harvard Medical School, Boston, MA (United States)] [and others



Analysis of ZLC desorption curves for gaseous systems  

Microsoft Academic Search

The theoretical model and underlying assumptions used in the analysis of ZLC (zero length column) desorption curves are examined in detail. It is shown that the long time analysis generally yields reliable diffusivity values although, if the initial equilibrium condition is not properly established there will be significant error in the apparent equilibrium constant. The short time analysis is much

Stefano Brandani; Douglas M. Ruthven



Linkage and sequence analysis indicate that CCBE1 is mutated in recessively inherited generalised lymphatic dysplasia.  


Generalised lymphatic dysplasia (GLD) is characterised by extensive peripheral lymphoedema with visceral involvement. In some cases, it presents in utero with hydrops fetalis. Autosomal dominant and recessive inheritance has been reported. A large, non-consanguineous family with three affected siblings with generalised lymphatic dysplasia is presented. One child died aged 5 months, one spontaneously miscarried at 17 weeks gestation, and the third has survived with extensive lymphoedema. All three presented with hydrops fetalis. There are seven other siblings who are clinically unaffected. Linkage analysis produced two loci on chromosome 18, covering 22 Mb and containing 150 genes, one of which is CCBE1. A homozygous cysteine to serine change in CCBE1 has been identified in the proband, in a residue that is conserved across species. High density SNP analysis revealed homozygosity (a region of 900 kb) around the locus for CCBE1 in all three affected cases. This indicates a likely ancestral mutation that is common to both parents; an example of a homozygous mutation representing Identity by Descent (IBD) in this pedigree. Recent studies in zebrafish have shown this gene to be required for lymphangiogenesis and venous sprouting and are therefore supportive of our findings. In view of the conserved nature of the cysteine, the nature of the amino acid change, the occurrence of a homozygous region around the locus, the segregation within the family, and the evidence from zebrafish, we propose that this mutation is causative for the generalised lymphatic dysplasia in this family, and may be of relevance in cases of non-immune hydrops fetalis. PMID:19911200

Connell, Fiona; Kalidas, Kamini; Ostergaard, Pia; Brice, Glen; Homfray, Tessa; Roberts, Lesley; Bunyan, David J; Mitton, Sally; Mansour, Sahar; Mortimer, Peter; Jeffery, Steve




Microsoft Academic Search

The effect that évapotranspiration has on recession curves during low flow periods is ex­ plored. Recession constants are obtained from flow data and plotted against the average daily pan evapora­ tion occurring during the recession. The results for the three study basins are similar, showing a decrease in recession constant with an increase in average daily pan evaporation. For low



Computer kinetic analysis of simultaneously obtained TG and DTG curves  

Microsoft Academic Search

The computer kinetic analysis of simultaneously obtained TG and DTG curves of CaCO3 decomposition has been carried out. Ten different kinetic equations have been tested to decide the mechanism which drives the reaction. Either a two-thirds kinetic equation (phase boundary process) or a Jander equation (diffusion process) satisfactorily describe the kinetic data of both decomposition curves. From these results we

J. M. Criado; J. Morales; V. Rives



Recession Rebound  

ERIC Educational Resources Information Center

A return to normal after a crisis is a good thing. Who doesn't want back what once seemed lost? The problem is it usually isn't a simple task figuring out how to patch together a scaled-back training program. When the recession hit in fall 2008, trainers were asked to scale down programming and make do with fewer resources. With a recovery in full…

Weinstein, Margery



Analysis of gate-lag phenomena in recessed-gate and buried-gate GaAs MESFETs  

Microsoft Academic Search

Two-dimensional analysis of gate-lag phenomena in recessed-gate and buried-gate GaAs MESFETs is performed, and their dependence on the structural parameters and the off-state gate voltage VGoff is studied. It is shown that when VGoff is around the threshold voltage (pinchoff voltage) Vth, the gate-lag could be almost eliminated by introducing the buried-gate structure. However, it is suggested that large gate-lag

Akira Wakabayashi; Yasutaka Mitani; Kazushige Horio



Recessions and seniors' health, health behaviors, and healthcare use: analysis of the Medicare Current Beneficiary Survey.  


A number of studies report that U.S. state mortality rates, particularly for the elderly, decline during economic downturns. Further, several prior studies use microdata to show that as state unemployment rates rise, physical health improves, unhealthy behaviors decrease, and medical care use declines. We use data on elderly mortality rates and data from the Medicare Current Beneficiary Survey from a time period that encompasses the start of the Great Recession. We find that elderly mortality is countercyclical during most of the 1994-2008 period. Further, as unemployment rates rise, seniors report worse mental health and are no more likely to engage in healthier behaviors. We find suggestive evidence that inpatient utilization increases perhaps because of an increased physician willingness to accept Medicare patients. Our findings suggest that either elderly individuals respond differently to recessions than do working age adults, or that the relationship between unemployment and health has changed. PMID:22898452

McInerney, Melissa; Mellor, Jennifer M



Molecular and phenotypic analysis of 25 recessive, homozygous-viable alleles at the mouse agouti locus  

Microsoft Academic Search

Agouti is a paracrine-acting, transient antagonist of melanocortin 1 receptors that specifies the subapical band of yellow on otherwise black hairs of the wild-type coat. To better understand both agouti structure\\/function and the germline damage caused by chemicals and radiation, an allelic series of 25 recessive, homozygous-viable agouti mutations generated in specific-locus tests were characterized. Visual inspection of fur, augmented

Rosalynn J. Miltenberger; Kazumasa Wakamatsu; Shosuke Ito; Richard P. Woychik; Liane B. Russell; Edward J. Michaud



Information, artifacts, and noise in dQ\\/dtQ recession analysis  

Microsoft Academic Search

The plotting of the time rate of change in discharge dQ\\/dt versus discharge Q has become a widely used tool for analyzing reces- sion data since Brutseart and Nieber (Water Resour Res 13 (1977) 637-643) proposed the method. Typically the time increment Dt over which the recession slope dQ\\/dt is approximated is held constant. It is shown here this that

David E. Rupp; John S. Selker



Testing Main Effects and Interactions in Latent Curve Analysis  

ERIC Educational Resources Information Center

|A key strength of latent curve analysis (LCA) is the ability to model individual variability in rates of change as a function of 1 or more explanatory variables. The measurement of time plays a critical role because the explanatory variables multiplicatively interact with time in the prediction of the repeated measures. However, this interaction…

Curran, Patrick J.; Bauer, Daniel J.; Willoughby, Michael T.



A Contribution to Heuristical Analysis of Experimental Decay Curves  

Microsoft Academic Search

A description of a computer program for the analysis of decay curves is presented in the international algorithmic language ALGOL 60. As it needs only a small subset of its facilities, it makes possible to implement the algorithm without obstacles in any laboratory with a computer. The algorithm needs efficiently less computer times than other methods, based on classical mathematical

E. Kindler



Shear flexible curved spline beam element for static analysis  

Microsoft Academic Search

In this paper, an efficient curved cubic B-spline beam element is developed based on field consistency principle, for the static analysis. The formulation is general in the sense that it includes anisotropy, transverse shear deformation, in-plane and rotary inertia effects. The element is based on laminated beam theory, which satisfies the interface stress and displacement continuity, and has a vanishing

M. Ganapathi; B. P. Patel; J. Saravanan; M. Touratier



Hybrid analytical technique for the nonlinear analysis of curved beams  

Microsoft Academic Search

The application of a two-step hybrid technique to the geometrically nonlinear analysis of curved beams is used to demonstrate the potential of hybrid analytical techniques in nonlinear structural mechanics. The hybrid technique is based on successive use of the perturbation method and a classical direct variational procedure. The functions associated with the various-order terms in the perturbation expansion of the

A. K. Noor; C. M. Andersen



Light Curve and Analysis of the Eclipsing Binary BF Centauri  

NASA Astrophysics Data System (ADS)

The eclipsing binary star BF Centauri was observed photometrically by GWW in the uvby filter system from Mt. John Observatory in New Zealand during 1982, 1989 and 1998. It was also observed spectroscopically at 10 A/mm by W. A. Lawson in 1993 at Mt. Stromlo in Australia to obtain a radial velocity solution. The combined light curves and spectroscopic results have been analyzed using the 1998 version of Robert Wilson's WD light-curve programs. A consistent model for the system will be presented. This analysis was done as a part of a senior research project by MAM, who would like to acknowledge financial support from the Missouri Space Grant Consortium.

Morris, M. A.; Wolf, G. W.



Analysis of surface-state effects on gate-lag phenomena in recessed-gate and buried-gate GaAs MESFETs  

Microsoft Academic Search

Gate-lag or slow current transient behaviour in GaAs MESFETs is studied by two-dimensional analysis including surface-state effects. It is shown that in a recessed-gate structure, the gate-lag is reduced to some extent by increasing the recess depth, but it may not be suppressed as much as expected because surface states around the gate affect the turn-on characteristics. However, by introducing

K. Horio; A. Wakabayashi; T. Yamada



Base-Flow Recession in Illinois.  

National Technical Information Service (NTIS)

Base-flow recession curves of nineteen Illinois streams were analyzed to determine the most significant factors which affected the base-flow recession rate. The eight most significant factors were (in order): number of days since the last major storm, ave...

R. N. Farvolden



Analysis of meteorology adjusted sulfate trend and the implication of recent recession impact  

NASA Astrophysics Data System (ADS)

Observed sulfate aerosols are mainly produced from the oxidation of sulfur dioxide (SO2) in the atmosphere. Most of the SO2 emissions, however, result from fossil fuel burning. For this reason, most of the aerosol produced from the oxidation of SO2 is considered to be from anthropogenic origins. Significant drops in the observed sulfate concentrations in 2008-2009 nationwide draw an interest to examine what may be the major driving forces behind this unusual event. In this study, 2002-2009 sulfate and meteorology data from 30 major cities nationwide were analyzed to examine the possible impact of the economic recession on observed sulfate concentration decreases. The results indicate that, on the average, a significant amount of the sulfate concentration drops observed in these urban areas during 2008 and 2009 cannot be explained by regulatory emission control effort alone. This is reflected in the meteorology adjusted sulfate trend. The remaining sulfate concentration decline is likely to come from additional SO2 reductions resulting from reduced economic activities, industrial productions and utility demands which was commonly realized almost everywhere in the country. Thus, it is determined that the economic recession must have a significant impact on the observed decreases of sulfate concentration in 2008 and 2009.

Chu, S.



Static and Dynamic J-R Curve Testing of A533B Steel Using the Key Curve Analysis Technique.  

National Technical Information Service (NTIS)

Elastic-plastic J-R curves are obtained for compact specimens of A533B-02 plate tested at average load point velocities of 0.010 inches/minute and 10 inches/second directly from the load displacement record using a key curve analysis technique. The slow v...

J. A. Joyce



An empirical analysis of titanium stress-strain curves  

Microsoft Academic Search

Stress-strain curves of titanium of two purity levels were analyzed by a Criissard and Jaoul method that assumes the Ludwik\\u000a equation ?= ?\\u000a 0 + k?p\\u000a n in the form where ? is the true stress and?\\u000a p the true plastic strain. The analysis shows that High purity titanium conforms to a simpler behavior pattern than commercial\\u000a purity titanium. In

S. N. Monteiro; R. E. Reed-Hill



Multi-wavelength analysis of Ellerman Bomb Light Curves  

NASA Astrophysics Data System (ADS)

We present the results of a multi-wavelength photometric analysis of Ellerman Bomb (EB) observations obtained from the Dutch Open Telescope. In our data we have found 6 EBs located in the super-penumbra of the main spot in the active region NOAA 10781. We present light curves of EB observed in the H? line centre and wing +0.7 Å, in the Ca II H line centre and wing~+2.35 Å, in the G-band and in the TRACE 1600 Å filter. We have shown that EBs were visible in the G-band and moreover, there was a good correlation between the light curves in the G-band and in the H? line wings. We also found quasi-periodic oscillations of EBs brightness in the G-band, CaII H line and TRACE 1600 Å filter.

Herlender, M.; Berlicki, A.


Molecular Analysis of DMP1 Mutants Causing Autosomal Recessive Hypophosphatemic Rickets  

PubMed Central

We previously demonstrated that the mutations Met1Val (M1V) and the deletion of nucleotides 1484-1490 (1484-1490del) in Dentin matrix protein-1 (DMP1) cause the novel disorder autosomal recessive hypophosphatemic rickets (ARHR), which is associated with elevated Fibroblast growth factor-23 (FGF23). To further understand the role of DMP1 in ARHR, we undertook molecular genetic and in vitro expression studies. First, we examined a kindred with a severe hypophosphatemic rickets phenotype and recessive inheritance. Analyses of this family demonstrated that the affected members had elevated serum FGF23 and carried a large, biallelic deletion that removed the majority of DMP1. At a minimum, this deletion encompassed 49 kb between DMP1 exon 3 and an intergenic region 5? to the next telomeric gene, integrin-binding sialoprotein (IBSP). We next performed immunofluorescent studies in cells to understand the effects of the known ARHR mutations on DMP1 cellular processing. These analyses showed that the M1V DMP1 mutant was not sorted to the trans-Golgi network (TGN) and secretory pathway, but filled the entire cytoplasm. In contrast, the 1484-1490del mutant localized to the TGN and was secreted, similar to wild type DMP1. The 1484-1490del mutation replaces the DMP1 18 C-terminal amino acids with 33 non-native residues. Truncation of wild type DMP1 by these native 18 residues followed by Western blot and confocal microscopic analyses demonstrated a wild type expression pattern when compared with the 1484-1490del mutant, indicating that the last 18 residues are not critical for cellular trafficking, but that the 33 additional residues arising from the 1484-1490del mutation likely compromise DMP1 processing. The relationship between DMP1 and FGF23 is unclear. To test endogenous DMP1 response to serum metabolites that also regulate FGF23, UMR-106 cells were treated with 1,25(OH)2 vitamin D (1×10?7M) and showed a 12-fold increase in DMP1 mRNA and protein at 24 hr. In summary, we have identified a novel DMP1 deletion as the cause of ARHR, as well as demonstrated that the ARHR mutations alter DMP1 cellular processing, and that DMP1 can be regulated by vitamin D. Taken together, this work expands our understanding of the genetic and molecular mechanisms associated with DMP1 alterations causing ARHR.

Farrow, Emily G.; Davis, Siobhan I.; Ward, Leanne M.; Summers, Lelia J.; Bubbear, Judith S.; Keen, Richard; Stamp, Trevor C.B.; Baker, Laurence R. I.; Bonewald, Lynda F.; White, Kenneth E.



Comprehensive clinical and molecular analysis of 12 families with type 1 recessive cutis laxa.  


Autosomal recessive cutis laxa type I (ARCL type I) is characterized by generalized cutis laxa with pulmonary emphysema and/or vascular complications. Rarely, mutations can be identified in FBLN4 or FBLN5. Recently, LTBP4 mutations have been implicated in a similar phenotype. Studying FBLN4, FBLN5, and LTBP4 in 12 families with ARCL type I, we found bi-allelic FBLN5 mutations in two probands, whereas nine probands harbored biallelic mutations in LTBP4. FBLN5 and LTBP4 mutations cause a very similar phenotype associated with severe pulmonary emphysema, in the absence of vascular tortuosity or aneurysms. Gastrointestinal and genitourinary tract involvement seems to be more severe in patients with LTBP4 mutations. Functional studies showed that most premature termination mutations in LTBP4 result in severely reduced mRNA and protein levels. This correlated with increased transforming growth factor-beta (TGF?) activity. However, one mutation, c.4127dupC, escaped nonsense-mediated decay. The corresponding mutant protein (p.Arg1377Alafs(*) 27) showed reduced colocalization with fibronectin, leading to an abnormal morphology of microfibrils in fibroblast cultures, while retaining normal TGF? activity. We conclude that LTBP4 mutations cause disease through both loss of function and gain of function mechanisms. PMID:22829427

Callewaert, Bert; Su, Chi-Ting; Van Damme, Tim; Vlummens, Philip; Malfait, Fransiska; Vanakker, Olivier; Schulz, Bianca; Mac Neal, Meghan; Davis, Elaine C; Lee, Joseph G H; Salhi, Aicha; Unger, Sheila; Heimdal, Ketil; De Almeida, Salome; Kornak, Uwe; Gaspar, Harald; Bresson, Jean-Luc; Prescott, Katrina; Gosendi, Maria E; Mansour, Sahar; Piérard, Gérald E; Madan-Khetarpal, Suneeta; Sciurba, Frank C; Symoens, Sofie; Coucke, Paul J; Van Maldergem, Lionel; Urban, Zsolt; De Paepe, Anne



Comparative proteomic analysis suggests that mitochondria are involved in autosomal recessive polycystic kidney disease.  


Autosomal recessive polycystic kidney disease (ARPKD), characterized by ectatic collecting duct, is an infantile form of PKD occurring in 1 in 20 000 births. Despite having been studied for many years, little is known about the underlying mechanisms. In the current study, we employed, for the first time, a MS-based comparative proteomics approach to investigate the differently expressed proteins between kidney tissue samples of four ARPKD and five control individuals. Thirty two differently expressed proteins were identified and six of the identified protein encoding genes performed on an independent group (three ARPKD subjects, four control subjects) were verified by semi-quantitative RT-PCR, and part of them were further validated by Western blot and immunohistochemistry. Moreover, similar alteration tendency was detected after downregulation of PKHD1 by small interfering RNA in HEK293T cell. Interestingly, most of the identified proteins are associated with mitochondria. This implies that mitochondria may be implicated in ARPKD. Furthermore, the String software was utilized to investigate the biological association network, which is based on known and predicted protein interactions. In conclusion, our findings depicted a global understanding of ARPKD progression and provided a promising resource of targeting protein, and shed some light further investigation of ARPKD. PMID:22718539

Li, Qing-Wei; Lu, Xiao-Yan; You, Yong; Sun, Huan; Liu, Xin-Yu; Ai, Jian-Zhong; Tan, Rui-Zhi; Chen, Tie-Lin; Chen, Mian-Zhi; Wang, Hong-Lian; Wei, Yu-Quan; Zhou, Qin



Detailed analysis of retinal function and morphology in a patient with autosomal recessive bestrophinopathy (ARB).  


The objective of the paper is to study the retinal microstructure and function in a patient with autosomal recessive bestrophinopathy (ARB). Retinal function and morphology assessment in a patient diagnosed with a biallelic mutation in the BEST1 gene (heterozygote mutations: Leu88del17 and A195V) included: full-field electroretinogram (ffERG) and multifocal electroretinogram (mfERG), electro-oculogram (EOG) testing, and imaging with a high-resolution Fourier-domain optical coherence tomography (Fd-OCT) system (UC Davis Medical Center; axial resolution: 4.5 microm, acquisition speed: 9 frames/s, 1,000 A-scans/frame) combined with a flexible scanning head (Bioptigen Inc.). The 11-year old asymptomatic boy showed a well-demarcated retinopathy with deposits. Functional assessment revealed normal visual acuity, reduced central mfERG responses, delayed rod and rod-cone b-wave ffERG responses, and reduced light rise in the EOG. Fd-OCT demonstrated RPE deposits, photoreceptor detachment, elongated and thickened photoreceptor outer segments, but preserved inner retinal layers. In conclusion, ARB associated retinal dystrophy shows functional and morphological changes that overlap with classic Best disease. For the first time, high-resolution imaging provided in vivo evidence of RPE and photoreceptor involvement in ARB. PMID:18985398

Gerth, Christina; Zawadzki, Robert J; Werner, John S; Héon, Elise



Two-dimensional analysis of gate-lag phenomena in recessed-gate GaAs MESFETs  

Microsoft Academic Search

The effects of surface states on turn-on characteristics of recessed-gate GaAs MESFETs are studied by two-dimensional simulation. It is found that the recess depth dr is deep and the distance between the gate and the recess edge Lr is set to be very narrow, the gate-lag (slow current transient) extinguishes for a case with surface states considered on horizontal planes

K. Horio; T. Yamada



An Analysis of Progress Curve Conceptual Advances and Progress Curve Uses, Since 1956.  

National Technical Information Service (NTIS)

The progress curve concept is traced in historical developments through 1956. The paper then concentrates on extensions of concepts through review and evaluation of articles and reports. Non-linearity is discussed, as is capital-intensive production and n...

V. Colasuonno



Extended kindred with recessive late-onset Alzheimer disease maps to locus 8p22-p21.2: a genome-wide linkage analysis.  


Late-onset Alzheimer disease (LOAD) is a complex genetic disorder. Although genes involved in early-onset forms were discovered more than a decade ago, LOAD research has only been able to point out small effect loci, with the exception of APOE. We mapped the gene predisposing to LOAD in an extended inbred family coming from a genetically isolated region (24 sampled individuals, 12 of whom are affected), completing a genome-wide screen with an Affymetrix10 K single nucleotide polymorphism microarray. Genotyping results were evaluated under model-dependent (dominant and recessive) and model-free analysis. We obtained a maximum nonparametric linkage score of 3.24 (P=0.00006) on chromosome 8p22-p21.2. The same genomic position also yielded the highest multipoint heterogeneity LOD (HLOD) under a recessive model (HLOD=3.04). When we compared the results of the model-dependent analysis, a higher score was obtained in the recessive model (3.04) than in the dominant model (1.0). This is a new locus identified in LOAD, in chromosome 8p22-p21.2 and encompassing several candidate genes, among them CLU and PPP3CC that were excluded by sequencing. The finding of a recessive model of inheritance, consistent with the assumption of inbreeding as a morbidity factor in this population, supports the notion of a role of recessive genes in LOAD. PMID:22354140

Baron, Manuel; Gomez-Tortosa, Estrella; Bochdanovits, Zoltan; Gobernado, Isabel; Rabano, Alberto; Munoz, David G; Heutink, Peter; Jimenez-Escrig, Adriano


Pressure analysis of an unstimulated horizontal well with type curves  

SciTech Connect

This paper reports that horizontal wells are effective alternatives to fractured vertical wells in several reservoir types, including low-permeability sandstones and shales. An understanding of fluid flow relationships is a prerequisite for efficient use of horizontal technology. The pressure-buildup data analyzed her were recorded in a horizontal completion in a low-permeability gas-bearing shale. The well was drilled and tested to verify laboratory and computer modeling research. After the general solutions were developed, the data were analyzed to describe reservoir properties and the effectiveness of the completion. Results of the type-curve analysis indicate that the contributing well length was shorter than the actual drilled length and that the contributing reservoir thickness was less than the typical net pay. Numerical modeling was used to verify the calculated parameters. Results fully support the well length and reservoir thickness determined through type-curve analysis, indicating that an unstimulated horizontal well completed in a heterogeneous formation may be insufficient to link the full vertical extent of the reservoir to the wellbore.

Duda, J.R. (Dept. of Energy (US)); Salamy, S.P. (BDM Engineering Service Co. (US)); Aminlan, K.; Ameri, S. (West Virginia Univ. (US))



Stochastic analysis of the VEGF receptor response curve  

NASA Astrophysics Data System (ADS)

Recently, an analysis of the response curve of the vascular endothelial growth factor (VEGF) receptor and its application to cancer therapy was described in [T. Alarcón, and K. Page, J. R. Soc. Lond. Interface 4, 283-304 (2007)]. The analysis is significantly extended here by demonstrating that an alternative computational strategy, namely the Krylov FSP algorithm for the direct solution of the chemical master equation, is feasible for the study of the receptor model. The new method allows us to further investigate the hypothesis of symmetry in the stochastic fluctuations of the response. Also, by augmenting the original model with a single reversible reaction we formulate a plausible mechanism capable of realizing a bimodal response, which is reported experimentally but which is not exhibited by the original model. The significance of these findings for mechanisms of tumour resistance to antiangiogenic therapy is discussed.

Macnamara, Shev; Burrage, Kevin; Sidje, Roger B.



Performance analysis of MANET using elliptic curve cryptosystem  

Microsoft Academic Search

In this work various elliptic curve are compared and evaluated based on their operations i.e. Addition and Doubling. Out of these elliptic curves classical weierstrass and jacobian elliptic curves are selected to implement in MANETs (Mobile Ad Hoc Networks) and further network performance is analyzed to calculate efficient processing unit in a partially distributed key management environment. To manipulate the

Adarsh Kumar; Alok Aggarwal; Charu



Suspension characteristics analysis running on curve for maglev train  

Microsoft Academic Search

The suspension characteristics of maglev train are studied in this paper when it is running on different curves. The suspension gap variation when maglev train is running on three different curves are presented. And the limitation to the vertical semi-diameter of the curve at the point where the grade of the longitudinal section of the track changes is also calculated.

Xiaolong Li; Zhizhou Zhang; Zhiqiang Long



Exclusion of the locus for autosomal recessive pseudohypoaldosteronism type 1 from the mineralocorticoid receptor gene region on human chromosome 4q by linkage analysis  

SciTech Connect

Pseudohypoaldosteronism type 1 (PHA1) is an uncommon inherited disorder characterized by salt-wasting in infancy arising from target organ unresponsiveness to mineralocorticoids. Clinical expression of the disease varies from severely affected infants who may die to apparently asymptomatic individuals. Inheritance is Mendelian and may be either autosomal dominant or autosomal recessive. A defect in the mineralocortiocoid receptor has been implicated as a likely cause of PHA1. The gene for human mineralocorticoid receptor (MLR) has been cloned and physically mapped to human chromosome 4q31.1-31.2. The etiological role of MLR in autosomal recessive PHA1 was investigated by performing linkage analysis between PHA1 and three simple sequence length polymorphisms (D4S192, D4S1548, and D4S413) on chromosome 4q in 10 consanguineous families. Linkage analysis was carried out assuming autosomal recessive inheritance with full penetrance and zero phenocopy rate using the MLINK program for two-point analysis and the HOMOZ program for multipoint analysis. Lod scores of less than -2 were obtained over the whole region from D4S192 to D4S413 encompassing MLR. This provides evidence against MLR as the site of mutations causing PHA1 in the majority of autosomal recessive families. 34 refs., 3 figs., 2 tabs.

Chung, E.; Hanukoglu, A.; Rees, M.; Thompson, R.; Gardiner, R.M. [Univ. College London Medical School, London (United Kingdom)] [and others



An item response curves analysis of the Force Concept Inventory  

NASA Astrophysics Data System (ADS)

Several years ago, we introduced the idea of item response curves (IRC), a simplistic form of item response theory (IRT), to the physics education research community as a way to examine item performance on diagnostic instruments such as the Force Concept Inventory (FCI). We noted that a full-blown analysis using IRT would be a next logical step, which several authors have since taken. In this paper, we show that our simple approach not only yields similar conclusions in the analysis of the performance of items on the FCI to the more sophisticated and complex IRT analyses but also permits additional insights by characterizing both the correct and incorrect answer choices. Our IRC approach can be applied to a variety of multiple-choice assessments but, as applied to a carefully designed instrument such as the FCI, allows us to probe student understanding as a function of ability level through an examination of each answer choice. We imagine that physics teachers could use IRC analysis to identify prominent misconceptions and tailor their instruction to combat those misconceptions, fulfilling the FCI authors' original intentions for its use. Furthermore, the IRC analysis can assist test designers to improve their assessments by identifying nonfunctioning distractors that can be replaced with distractors attractive to students at various ability levels.

Morris, Gary A.; Harshman, Nathan; Branum-Martin, Lee; Mazur, Eric; Mzoughi, Taha; Baker, Stephen D.



Concentrated photovoltaics system costs and learning curve analysis  

NASA Astrophysics Data System (ADS)

An extensive set of costs in $/W for the installed costs of CPV systems has been amassed from a range of public sources, including both individual company prices and market reports. Cost reductions over time are very evident, with current prices for 2012 in the range of 3.0 +/- 0.7 $/W and a predicted cost of 1.5 $/W for 2020. Cost data is combined with deployment volumes in a learning curve analysis, providing a fitted learning rate of either 18.5% or 22.3% depending on the methodology. This learning rate is compared to that of PV modules and PV installed systems, and the influence of soft costs is discussed. Finally, if an annual growth rate of 39% is assumed for deployed volumes, then, using the learning rate of 20%, this would predict the achievement of a cost point of 1.5 $/W by 2016.

Haysom, Joan E.; Jafarieh, Omid; Anis, Hanan; Hinzer, Karin



Descriptive and Predictive Growth Curves in Energy System Analysis  

Microsoft Academic Search

This study reviews a variety of growth curve models and the theoretical frameworks that lay behind them. In many systems,\\u000a growth patterns are, or must, ultimately be subjected to some form of limitation. A number of curve models have been developed\\u000a to describe and predict such behaviours. Symmetric growth curves have frequently been used for forecasting fossil fuel production,\\u000a but

Mikael Höök; Junchen Li; Noriaki Oba; Simon Snowden



Growth curve analysis for plasma profiles using smoothing splines  

SciTech Connect

We are developing a profile analysis code for the statistical estimation of the parametric dependencies of the temperature and density profiles in tokamaks. Our code uses advanced statistical techniques to determine the optimal fit, i.e. the fit which minimized the predictive error. For a forty TFTR Ohmic profile dataset, our preliminary results indicate that the profile shape depends almost exclusively on q[sub a][prime] but that the shape dependencies are not Gaussian. We are now comparing various shape models on the TFTR data. In the first six months, we have completed the core modules of the code, including a B-spline package for variable knot locations, a data-based method to determine the optimal smoothing parameters, self-consistent estimation of the bias errors, and adaptive fitting near the plasma edge. Visualization graphics already include three dimensional surface plots, and discharge by discharge plots of the predicted curves with error bars together with the actual measurements values, and plots of the basis functions with errors.

Imre, K.



Functional nanoparticles translocation into cell and adhesion force curve analysis.  


The aim of this research is to investigate the cell translocation of two functional nanoparticles (barium sulfate (BaSO4NPs), europium (III) doped gadolinium oxide nanoparticles (Gd2O3@EuNPs)) into A549 cells by Bio-Atomic Force Microscopy (Bio-AFM). Successful cell translocation of these two nanoparticles are ensured from the measurement of changes in the cell surface roughness and interaction (extension), retraction forces from the vertical deflection of tip towards substrate surfaces through force-distance curve slope analysis. Measurement of typical adhesion forces (i.e., extension and retraction) between the tip-substrate (0.0963 and 1.155 nN), tip-A549 cell substrate (0.1177 and 2.468 nN), tip-Gd2O3@EuNPs/A549 substrate (0.0785 and 0.4276 nN) and tip-BaSO4NPs/A549 substrate (0.518 and 6.838 nN) confirms the successful cell translocation of functional nanoparticles into A549 cells. Further the nanoscale resolution of topographical height and 3D images evinces the surface characteristics of normal A549 cells and nanoparticles translocated A549 cells. PMID:23421137

Lee, Haisung; Veerapandian, Murugan; Kim, Byung Tae; Yun, Kyusik; Seo, Soo-Won



Growth rate models: emphasizing growth rate analysis through growth curve modeling  

Microsoft Academic Search

To emphasize growth rate analysis, we develop a general method to reparametrize growth curve models to analyze rates of growth for a variety of growth trajectories, such as quadratic and exponential growth. The resulting growth rate models are shown to be related to rotations of growth curves. Estimated conveniently through growth curve modeling techniques, growth rate models have advantages above

Zhiyong Zhang; John J. McArdle; John R. Nesselroade



Growth rate models: emphasizing growth rate analysis through growth curve modeling  

Microsoft Academic Search

To emphasize growth rate analysis, we develop a general method to reparametrize growth curve models to analyze rates of growth for a variety of growth trajectories, such as quadratic and exponential growth. The resulting growth rate models are shown to be related to rotations of growth curves. Estimated conveniently through growth curve modeling techniques, growth rate models have advantages above

Zhiyong Zhang; John J. McArdle; John R. Nesselroade



Prediction of scoliosis curve type based on the analysis of trunk surface topography  

Microsoft Academic Search

Scoliosis treatment strategy is generally chosen according to the severity and type of the spinal curve. Currently, the curve type is determined from X-rays whose acquisition can be harmful for the patient. We propose in this paper a system that can predict the scoliosis curve type based on the analysis of the surface of the trunk. The latter is acquired

Lama Seoud; Mathias M. Adankon; Hubert Labelle; Jean Dansereau; Farida Cheriet



Free vibration analysis of horizontally curved steel I-girder bridges  

Microsoft Academic Search

Presented herein is a finite element formulation for free vibration analysis of horizontally curved steel I-girder bridges. Stiffness as well as mass matrices of the curved and the straight beam elements is formulated. Each node of both of them possesses seven degrees of freedom including the warping degree of freedom. The curved beam element is derived based on the Kang

Ki-Young Yoon; Young-Jong Kang; Young-Joon Choi; Nam-Hoi Park



Analysis-of-Variance Tests in the Analysis and Comparison of Curves  

Microsoft Academic Search

The purpose of this paper is to extend methods presently available for use in the analysis and the comparison of curves obtained in psychological experiments. The reader will be assumed to have a general acquaintanceship with analysis-of variance techniques at an elementary level, such as could be obtained from most of the better available textbooks. The present paper will deal

David A. Grant



Analysis of growth curves of fowl. II. Ducks  

Microsoft Academic Search

1. Growth curves of nine selected lines and one random?bred control population (in total, n=1070) were evaluated by the Richards function. The ducks were weighed at 7?d intervals and, after the tenth week, every second week (up to 18 weeks). Food and water were supplied ad libitum.2. The predicted curves closely fitted the weight data points (R = 0.9991–0.9997).3. The

H. Knížetová; J. Hyánek; B. Kníže; H. Procházková



Scoliosis associated with syringomyelia: analysis of MRI and curve progression  

Microsoft Academic Search

Little is known about the natural history of scoliosis found in patients with syringomyelia, including the factors affecting\\u000a scoliosis curve progression and the effect of syrinx drainage treatment. Twenty patients having scoliosis with syringomyelia\\u000a diagnosed by MRI were followed up for 6.6 (range 2.0–12.6) years on an average. Various factors potentially influencing curve\\u000a pattern or progression in these patients were

Jin Sup Yeom; Choon-Ki Lee; Kun-Woo Park; Jae Hyup Lee; Dong-Ho Lee; Kyu-Chang Wang; Bong-Soon Chang



Analysis of progress curves by simulations generated by numerical integration.  

PubMed Central

A highly flexible computer program written in FORTRAN is presented which fits computer-generated simulations to experimental progress-curve data by an iterative non-linear weighted least-squares procedure. This fitting procedure allows kinetic rate constants to be determined from the experimental progress curves. Although the numerical integration of the rate equations by a previously described method [Barshop, Wrenn & Frieden (1983) Anal. Biochem. 130, 134-145] is used here to generate predicted curves, any routine capable of the integration of a set of differential equations can be used. The fitting program described is designed to be widely applicable, easy to learn and convenient to use. The use, behaviour and power of the program is explored by using simulated test data.

Zimmerle, C T; Frieden, C



Analysis of missense variants in the PKHD1 -gene in patients with autosomal recessive polycystic kidney disease (ARPKD)  

Microsoft Academic Search

Autosomal recessive polycystic kidney disease (ARPKD) is a severe form of polycystic kidney disease characterized by enlarged kidneys and congenital hepatic fibrosis. Given the poor prognosis for the majority of children with the severe perinatal ARPKD phenotype, there is a regular request for prenatal testing. ARPKD is caused by mutations in the polycystic kidney and hepatic disease 1 (PKHD1) gene,

Monique Losekoot; Cathleen Haarloo; Claudia Ruivenkamp; Stefan J. White; Martijn H. Breuning; Dorien J. M. Peters



Mediation Analysis in a Latent Growth Curve Modeling Framework  

ERIC Educational Resources Information Center

|This article presents several longitudinal mediation models in the framework of latent growth curve modeling and provides a detailed account of how such models can be constructed. Logical and statistical challenges that might arise when such analyses are conducted are also discussed. Specifically, we discuss how the initial status (intercept) and…

von Soest, Tilmann; Hagtvet, Knut A.



Vibration Analysis of Composite Rectangular Plates Reinforced along Curved Lines  

Microsoft Academic Search

In the past few decades, composite materials composed of straight fibers and polymer matrix have gained their status as the most promising material for light-weight structures. Technical merit of the composites as tailored material also provided practical advantages in the optimum design process. Recently, it is reported that the fabrication machine has been developed to make curved fibers embedded in

Shinya Honda; Yoshimasa Oonishi; Yoshihiro Narita; Katsuhiko Sasaki



Mediation Analysis in a Latent Growth Curve Modeling Framework  

ERIC Educational Resources Information Center

This article presents several longitudinal mediation models in the framework of latent growth curve modeling and provides a detailed account of how such models can be constructed. Logical and statistical challenges that might arise when such analyses are conducted are also discussed. Specifically, we discuss how the initial status (intercept) and…

von Soest, Tilmann; Hagtvet, Knut A.



Light Curve Analysis of the ES UMa Binary  

NASA Astrophysics Data System (ADS)

We present a number of multi-night photometric observations of the ES UMa system, carried out from 28/2/07 to 2/6/07 in B, V, R and Ic filters. From these observations, a light curve solution has been acquired.

Kleidis, S.; Tsantilas, S.; Rovithis-Livaniou, H.



Bayesian Analysis of Longitudinal Data Using Growth Curve Models  

ERIC Educational Resources Information Center

Bayesian methods for analyzing longitudinal data in social and behavioral research are recommended for their ability to incorporate prior information in estimating simple and complex models. We first summarize the basics of Bayesian methods before presenting an empirical example in which we fit a latent basis growth curve model to achievement data…

Zhang, Zhiyong; Hamagami, Fumiaki; Wang, Lijuan Lijuan; Nesselroade, John R.; Grimm, Kevin J.



Performance analysis of elliptic curve cryptography for SSL  

Microsoft Academic Search

Elliptic Curve Cryptography (ECC) is emerging as an attractive public-key cryptosystem for mobile\\/wireless environments. Compared to traditional cryptosystems like RSA, ECC offers equivalent security with smaller key sizes, which results in faster computations, lower power consumption, as well as memory and bandwidth savings. This is especially useful for mobile devices which are typically limited in terms of their CPU, power

Vipul Gupta; Sumit Gupta; Sheueling Chang; Douglas Stebila



Soil water retention curve analysis using radial basis function network  

Microsoft Academic Search

The soil water retention curve (SWRC) shows the relationship between soil suction pressure and water content, which is one of the key hydraulic properties to study the flow and solute transports in unsaturated zone. A radial basis function network (RBFN) was developed to describe the SWRC with the observed soil suction pressure and simultaneous soil water content derived from laboratory

Jin Gao; Yanfeng Liu




Microsoft Academic Search

There are many negatives that result from a recession and causes poverty, years of rebuilding economically, and the bankruptcy of major companies that need government bailouts; however, in turn worsening the debt of a government. Many believe that the recession started in the United States and spread thereafter. The boom in the housing market in 2001 was driving the economy




Starving for Recess  

ERIC Educational Resources Information Center

|Every weekday, millions of American schoolchildren throw away their half-eaten cafeteria lunches so that they can run outside to play. The traditional placement of lunch before recess, coupled with the recent decline in overall recess time to meet academic time constraints, forces children to choose between two essential needs: (1) food; and (2)…

Patt, Mary Johnson



Recess--It's Indispensable!  

ERIC Educational Resources Information Center

|The demise of recess in many elementary schools--and of outdoor play in general--is an issue of great concern to many members of the Play, Policy, and Practice Interest Forum. Most people remember recess as an important part of the school day. It was a time to be outdoors; to organize games; to play on the swings, slides, and other playground…

Jarrett, Olga; Waite-Stupiansky, Sandra



Analysis of the optical light curve of LMC X-3  

NASA Astrophysics Data System (ADS)

The optical orbital light curve of the X-ray binary LMC X-3 is analyzed using a model comprising ellipsoidal variations, X-ray heating of the companion star, and the effects of an accretion disk (as an additional source of optical emission, partial X-ray shielding of the companion, and possible mutual eclipses). Using observational constraints on the system (mass function, apparent visual magnitude and spectral type of the companion star), it is found that the observed amplitudes of the optical light curve constrain the mass M(x) of the compact star in LMC X-3 to be within the range (4.5-6.5) (d/50 kpc) solar masses. Within the framework of this model for the optical variations of LMC X-3, the compact star in this system is likely a black hole.

Kuiper, L.; van Paradijs, J.; van der Klis, M.



THE EFFECT OF EVAPOTRANSPIRATION ON STREAMFLOW RECESSION \\/ L'effet de l'évapotranspiration sur l'écoulement en décrue  

Microsoft Academic Search

The effect that evapotranspiration has on recession curves during low flow periods is explored. Recession constants are obtained from flow data and plotted against the average daily pan evaporation occurring during the recession. The results for the three study basins are similar, showing a decrease in recession constant with an increase in average daily pan evaporation. For low values of




Integration of Kinetic Analysis of Reaction Curve with a Proper Classical Approach for Enzymatic Analysis  

PubMed Central

For enzymatic analysis to quantify a substrate or enzyme, kinetic analysis of reaction curve can be integrated with a proper classical approach. For their integration, they should have consistent slopes and intercepts of linear response and an overlapped region of analyte quantities measurable under optimized conditions. To quantify a substrate after optimizations of tool enzyme activity and reaction duration, the equilibrium method works when the reaction is completed within the reaction duration; otherwise, kinetic analysis of reaction curve applies providing at least seven data with sufficient consumption of substrate. To quantify an enzyme after optimizations of initial substrate concentration and reaction duration, the classical initial rate method works when an estimated initial rate locates within the linear range; otherwise, kinetic analysis of reaction curve applies after the conversion of the quantification index with optimized parameters. This integration strategy has ideal linear ranges and practical efficiency for quantifying an enzyme at moderate substrate levels and for quantifying a substrate at moderate cost on tool enzyme; it has promise to simultaneous assays of multiple enzymes in one reaction vessel each time and ,thus, potential applications to concurrently quantify multiple serum enzymes, screen inhibitors against multiple enzyme targets, and detect multiple serum components by enzymeimmunoassay.

Yang, Xiaolan; Long, Gaobo; Jiang, Hairong; Liao, Pu; Liao, Fei



A structural analysis of the kinetic fatigue failure curves of constructional steels  

Microsoft Academic Search

Investigation of the cyclic crack resistance of constructional materials leads unavoidably to the construction and analysis of kinetic fatigue failure curves. Such curves reflect from the standpoint of fracture mechanics the life and reliability of a material and its specific capacity in comparison with other materials. As a rule such determinations are made graphically by plotting the individual kinetic fatigue

O. N. Romaniv; A. N. Tkach



Autosomal recessive juvenile parkinsonism  

Microsoft Academic Search

Autosomal recessive juvenile parkinsonism (AR-JP) is a hereditary neurodegenerative disorder characterized by levodopa-responsive parkinsonism with onset before age 40 years and a slowly progressive course. Families with this condition have been described predominantly in Japanese population, occasionally under different names including an autosomal recessive early-onset parkinsonism with diurnal fluctuation (AR-EPDF) or a familial form of juvenile parkinsonism. Recently, the causative

Masaaki Saito; Mieko Maruyama; Ken Ikeuchi; Hiroshi Kondo; Atsushi Ishikawa; Tatsuhiko Yuasa; Shoji Tsuji



Why does the Cost of Credit Intermediation Increase for Small Firms Relative to Large Firms during Recessions? A Conceptual and Empirical Analysis  

Microsoft Academic Search

The Great Recession of 2007-09 has had a devastating and long-lasting effect on the US economy. New Institutional Theories (NIT) of finance contend that part of the explanation for the amplification and duration of economic recessions resides in the presence of asymmetric information and market imperfections in the credit market. During recessions, smaller firms without established credit records and low

Miguel Ramirez; Aalok Pandey



Identification of feline polycystic kidney disease mutation using fret probes and melting curve analysis  

Microsoft Academic Search

We developed and validated a real-time polymerase chain reaction (PCR) assay using fluorescent hybridization probes and melting curve analysis to identify the PKD1 exon 29 (C?A) mutation, which is implicated in polycystic kidney disease of cats. DNA was isolated from peripheral blood of 20 Persian cats. The employ of the new real-time PCR and melting curve analysis in these samples

A. Criado-Fornelio; A. Buling; J. C. Barba-Carretero



Determination of the optimum working range from a calibration curve for colorimetric analysis with an "autoanalyzer".  


A study has been made of the types and distribution of errors in determining the optimum working range from a calibration curve for automated analysis. Three error equations are derived for the fitting of a linear, quadratic or cubic curve, involving a thorough statistical analysis of the data. The errors from a set of silica and alumina standards, requiring a quadratic and cubic fit respectively, compare favourably with replicate analyses of standard rocks done on a previous occasion. PMID:18961254

Whitehead, D



Parent involvement and science achievement: A latent growth curve analysis  

NASA Astrophysics Data System (ADS)

This study examined science achievement growth across elementary and middle school and parent school involvement using the Early Childhood Longitudinal Study - Kindergarten Class of 1998--1999 (ECLS-K). The ECLS-K is a nationally representative kindergarten cohort of students from public and private schools who attended full-day or half-day kindergarten class in 1998--1999. The present study's sample (N = 8,070) was based on students that had a sampling weight available from the public-use data file. Students were assessed in science achievement at third, fifth, and eighth grades and parents of the students were surveyed at the same time points. Analyses using latent growth curve modeling with time invariant and varying covariates in an SEM framework revealed a positive relationship between science achievement and parent involvement at eighth grade. Furthermore, there were gender and racial/ethnic differences in parents' school involvement as a predictor of science achievement. Findings indicated that students with lower initial science achievement scores had a faster rate of growth across time. The achievement gap between low and high achievers in earth, space and life sciences lessened from elementary to middle school. Parents' involvement with school usually tapers off after elementary school, but due to parent school involvement being a significant predictor of eighth grade science achievement, later school involvement may need to be supported and better implemented in secondary schooling.

Johnson, Ursula Yvette


Obtaining DDF Curves of Extreme Rainfall Data Using Bivariate Copula and Frequency Analysis  

NASA Astrophysics Data System (ADS)

The traditional rainfall intensity-duration-frequency (IDF) curve is a reliable approach for representing the variation of rainfall intensity with duration for a given return period. In reality rainfall variables intensity, depth and duration are dependent and therefore a bivariate analysis using copulas can give a more accurate IDF curve. We study IDF curves using a copula in a bivariate frequency analysis of extreme rainfall. To be able to choose the most suitable copula among candidate copulas (i.e., Gumbel, Clayton, and Frank) we demonstrated IDF curves based on variation of depth with duration for a given return period and name them DDF (depth-duration-frequency) curves. The copula approach does not assume the rainfall variables are independent or jointly normally distributed. Rainfall series are extracted in three ways: (1) by maximum mean intensity; (2) by depth and duration of individual rainfall events; and (3) by storage volume and duration. In each case we used partial duration series (PDS) to extract extreme rainfall variables. The DDF curves derived from each method are presented and compared. This study examines extreme rainfall data from catchment Vedbæ k Renseanlæ g, situated near Copenhagen in Denmark. For rainfall extracted using method 2, the marginal distribution of depth was found to fit the Generalized Pareto distribution while duration was found to fit the Gamma distribution, using the method of L-moments. The volume was fit with a generalized Pareto distribution and the duration was fit with a Pearson type III distribution for rainfall extracted using method 3. The Clayton copula was found to be appropriate for bivariate analysis of rainfall depth and duration for both methods 2 and 3. DDF curves derived using the Clayton copula for depth and duration of individual rainfall events (method 2) are in agreement with empirically derived DDF curves obtained from maximum mean intensity (method 1) for a 10-year return period. For a 100-year return period the estimates differ by 2.5 cm for a 5 hr duration. This difference diminishes to almost zero for a 50 hr duration. If rainfall series are extracted by storage volume and duration (method 3), the difference between DDF curves derived from the Clayton copula and the empirical DDF curves are more appreciable and in general, DDF curves derived from method 3 show a smaller depth for the same duration for any selected return period. The differences between DDF curves illustrates that the method of extracting extreme rainfall as well as the frequency analysis approach have a considerable effect on the resulting DDF curves.

Sadri, S.; Madsen, H.; Mikkelsen, P. S.; Burn, D. H.



Differentiation of Mycoplasma gallisepticum strains using PCR and high-resolution melting curve analysis.  


Mycoplasma gallisepticum (MG) is an economically important pathogen of poultry worldwide, causing chronic respiratory disease in chickens and turkeys. Differentiation of MG strains is critical, especially in countries where poultry flocks are vaccinated with live vaccines. In this study, oligonucleotide primers were designed based on a region preceding the trinucleotide repeat of a member of the vlhA gene family, and amplicons of 145-352 bp were generated from cultures of 10 different MG strains, including the ts-11, F and 6/85 vaccine strains. High-resolution melting (HRM) curve analysis of the resultant amplicons could differentiate all MG strains. Analysis of the nucleotide sequences of the amplicons from each strain revealed that each melting curve profile related to a unique DNA sequence. The HRM curve profiles (for ts-11) remained consistent after at least five passages under laboratory conditions. PCR-HRM curve analysis of 33 DNA extracts derived from respiratory swabs, or mycoplasma cultures grown from respiratory swabs, of ts-11-vaccinated commercial or specific pathogen-free chickens identified all these specimens, according to their sequences, as ts-11. The potential of the PCR-HRM curve analysis was also shown in the genotyping of 30 additional MG isolates from Europe, the USA and Israel. The results presented in this study indicate that PCR followed by HRM curve analysis provides a rapid and robust technique for genotyping of MG isolates/strains using both MG cultures and clinical swabs. PMID:20035007

Ghorashi, Seyed A; Noormohammadi, Amir H; Markham, Philip F



First-Order Reversal Curve (FORC) analysis of chondrule magnetism  

NASA Astrophysics Data System (ADS)

We report a rock magnetic study of the magnetic properties of chondrules from the Allende and Mokoia carbonaceous chondritic meteorites. To characterise the magnetic carriers, we have made detailed magnetic hysteresis analysis including FORC measurements. We have also conducted isothermal acquisition unmixing analysis. We have determined the ancient magnetic field intensities (paleointensities) recorded by the two meteorites. As these chondrules are highly susceptible to chemical alteration on heating, we have employed two non-heating methods of determining the ancient field intensity: (1) the calibrated REM method and (2) the newly developed Preisach-based approach that determines absolute paleointensities. Allende has been extensively studied but this is the first paleointensity estimate for the Mokoia meteorite.

Emmerton, S.; Muxworthy, A. R.



A light-curve distortion-wave analysis of eight RS Canum Venaticorum systems  

NASA Astrophysics Data System (ADS)

A program of differential U,B,V photometry of 14 RS CVn systems carried out at Rosemary Hill Observatory in 1978 - 1981 is described, and an analysis of the light curves for the characteristic distortion wave for eight of the systems is presented. The V light curves of the systems are shown. Significant waves were observed in RS CVn, RZ Eri, and RW UMa. No significant waves were found in UX Com, GK Hya, AR Lac, LX Per, or TY Pyx. Unusual light curve distortions were observed in UX Com and AR Lac.

Caton, D. B.



Detection of methylation in promoter sequences by melting curve analysis-based semiquantitative real time PCR  

Microsoft Academic Search

BACKGROUND: We present two melting curve analysis (MCA)-based semiquantitative real time PCR techniques to detect the promoter methylation status of genes. The first, MCA-MSP, follows the same principle as standard MSP but it is performed in a real time thermalcycler with results being visualized in a melting curve. The second, MCA-Meth, uses a single pair of primers designed with no

Aiala Lorente; Wolf Mueller; Edurne Urdangarín; Paula Lázcoz; Andreas von Deimling; Javier S Castresana



A Fourier method for the analysis of exponential decay curves.  

PubMed Central

A method based on the Fourier convolution theorem is developed for the analysis of data composed of random noise, plus an unknown constant "base line," plus a sum of (or an integral over a continuous spectrum of) exponential decay functions. The Fourier method's usual serious practical limitation of needing high accuracy data over a very wide range is eliminated by the introduction of convergence parameters and a Gaussian taper window. A computer program is described for the analysis of discrete spectra, where the data involves only a sum of exponentials. The program is completely automatic in that the only necessary inputs are the raw data (not necessarily in equal intervals of time); no potentially biased initial guesses concerning either the number or the values of the components are needed. The outputs include the number of components, the amplitudes and time constants together with their estimated errors, and a spectral plot of the solution. The limiting resolving power of the method is studied by analyzing a wide range of simulated two-, three-, and four-component data. The results seem to indicate that the method is applicable over a considerably wider range of conditions than nonlinear least squares or the method of moments.

Provencher, S W




SciTech Connect

We present a comprehensive statistical analysis of the properties of Type Ia supernova (SN Ia) light curves in the near-infrared using recent data from Peters Automated InfraRed Imaging TELescope and the literature. We construct a hierarchical Bayesian framework, incorporating several uncertainties including photometric error, peculiar velocities, dust extinction, and intrinsic variations, for principled and coherent statistical inference. SN Ia light-curve inferences are drawn from the global posterior probability of parameters describing both individual supernovae and the population conditioned on the entire SN Ia NIR data set. The logical structure of the hierarchical model is represented by a directed acyclic graph. Fully Bayesian analysis of the model and data is enabled by an efficient Markov Chain Monte Carlo algorithm exploiting the conditional probabilistic structure using Gibbs sampling. We apply this framework to the JHK{sub s} SN Ia light-curve data. A new light-curve model captures the observed J-band light-curve shape variations. The marginal intrinsic variances in peak absolute magnitudes are sigma(M{sub J}) = 0.17 +- 0.03, sigma(M{sub H}) = 0.11 +- 0.03, and sigma(M{sub Ks}) = 0.19 +- 0.04. We describe the first quantitative evidence for correlations between the NIR absolute magnitudes and J-band light-curve shapes, and demonstrate their utility for distance estimation. The average residual in the Hubble diagram for the training set SNe at cz > 2000kms{sup -1} is 0.10 mag. The new application of bootstrap cross-validation to SN Ia light-curve inference tests the sensitivity of the statistical model fit to the finite sample and estimates the prediction error at 0.15 mag. These results demonstrate that SN Ia NIR light curves are as effective as corrected optical light curves, and, because they are less vulnerable to dust absorption, they have great potential as precise and accurate cosmological distance indicators.

Mandel, Kaisey S.; Friedman, Andrew S.; Kirshner, Robert P. [Harvard-Smithsonian Center for Astrophysics, 60 Garden St., Cambridge, MA 02138 (United States); Wood-Vasey, W. Michael, E-mail: kmandel@cfa.harvard.ed [Current address: Department of Physics and Astronomy, 100 Allen Hall, 3941 O'Hara St., University of Pittsburgh, Pittsburgh, PA 15260 (United States)



Sex determination in beef by melting curve analysis of PCR amplicons from the amelogenin locus.  


Sex determination of beef is important to meet the rules of the Commission Regulation (EC) 765/2002 that qualify for export refunds. A SYBR Green sex identification assay based on melting curve analysis of PCR amplicons from the amelogenin locus (AMELX and AMELY) was developed. The PCR amplicons of 130/130 and 130/67 base pairs produced from female and male beef, respectively, are easily distinguished by both melting curve analysis and gel electrophoresis. Results from the melting curve analysis of amplicons are ready in less than three minutes, and requires no additional work in addition to the PCR setup. Applicability of the sex determination assay was studied by analysis of 12 unknown beef samples and the results were compared to an accredited method based on gel electrophoresis. In addition, six different cattle breeds were examined. All test results were correct in respect to sex. PMID:22061791

Ballin, Nicolai Z; Madsen, Knud G



Posterior Cruciate Ligament Recession  

Microsoft Academic Search

Summary: Three cases of posterior cruciate ligament (PCL) laxity without posterolateral rotatory instability had magnetic resonance imaging scans that documented the structural continuity of the PCL. Tibial PCL recession was effective in eliminating symptomatic laxity in 1 case and lacked efficacy in the other 2 cases.Arthroscopy: The Journal of Arthroscopic and Related Surgery, Vol 15, No 6 (July), 1999: pp

Eugene E. Berg



Application of the normalization data analysis technique for single specimen R-curve determination  

SciTech Connect

The authors conclude that the normalization technique for single specimen R-curve and J{sub IC} determination can be very effective. Much like EPD, this technique requires some user interpretation/judgement during data analysis and may be difficult to standardize or fully automate even with strict analysis rules.

Porr, W.C.; Mills, W.J.



Spectral analysis of stellar light curves by means of neural networks  

Microsoft Academic Search

Periodicity analysis of unevenly collected data is a relevant issue in several scientific fields. In astrophysics, for example, we have to find the fundamental period of light or radial velocity curves which are unevenly sampled observations of stars. Classical spectral analysis methods are unsatisfactory to solve the problem. In this paper we present a neural network based estimator system which

R. Tagliaferri; A. Ciaramella; L. Milano; F. Barone; G. Longo



Multivariate Curve Resolution for Hyperspectral Image Analysis: Applications to Microarray Technology  

Microsoft Academic Search

Multivariate curve resolution (MCR) using constrained alternating least squares algorithms represents a powerful analysis capability for the quantitative analysis of hyperspectral image data. We will demonstrate the application of MCR using data from a new hyperspectral fluorescence imaging microarray scanner for monitoring gene expression in cells from thousands of genes on the array. The new scanner collects the entire fluorescence

David M. Haaland; Jerilyn A. Timlin; Michael B. Sinclair; Mark H. Van Benthem


Multivariate curve resolution for hyperspectral image analysis: applications to microarray technology  

Microsoft Academic Search

Multivariate curve resolution (MCR) using constrained alternating least squares algorithms represents a powerful analysis capability for a quantitative analysis of hyperspectral image data. We will demonstrate the application of MCR using data from a new hyperspectral fluorescence imaging microarray scanner for monitoring gene expression in cells from thousands of genes on the array. The new scanner collects the entire fluorescence

David M. Haaland; Jerilyn A. Timlin; Michael B. Sinclair; Mark H. Van Benthem; M. Juanita Martinez; Anthony D. Aragon; Margaret Werner-Washburne



Genome-wide linkage analysis of an autosomal recessive hypotrichosis identifies a novel P2RY5 mutation  

PubMed Central

While there have been significant advances in understanding the genetic etiology of human hair loss over the previous decade, there remain a number of hereditary disorders for which a causative gene has yet to be identified. We studied a large, consanguineous Brazilian family that presented with sparse woolly hair at birth that progressed to severe hypotrichosis by the age of 5, in which 6 of the 14 offspring were affected. After exclusion of known candidate genes, a genome-wide scan was performed to identify the disease locus. Autozygosity mapping revealed a highly significant region of extended homozygosity (LOD score of 10.41) that contained a haplotype with a linkage LOD score of 3.28. Results of these two methods defined a 9 Mb region on chromosome 13q14.11-q14.2. The interval contains the P2RY5 gene, in which we recently identified pathogenic mutations in several families of Pakistani origin affected with autosomal recessive woolly and sparse hair. After the exclusion of several other candidate genes, we sequenced the P2RY5 gene and identified a homozygous mutation (C278Y) in all affected individuals in this family. Our findings show that mutations in P2RY5 display variable expressivity, underlying both hypotrichosis and woolly hair, and underscore the essential role of P2RY5 in the tissue integrity and the maintenance of the hair follicle.

Petukhova, Lynn; Sousa, Edilson C.; Martinez-Mir, Amalia; Vitebsky, Anna; dos Santos, Lina G; Shapiro, Lawrence; Haynes, Chad; Gordon, Derek; Shimomura, Yutaka; Christiano, Angela M.



Molecular analysis of the pre-BCR complex in a large cohort of patients affected by autosomal-recessive agammaglobulinemia.  


Autosomal-recessive agammaglobulinemia is a rare and heterogeneous disorder, characterized by early-onset infections, profound hypogammaglobulinemia of all immunoglobulin isotypes and absence of circulating B lymphocytes. To investigate the molecular basis of the disease, 23 patients with early-onset disease and no mutations in Bruton tyrosine kinase, the gene responsible for X-linked agammaglobulinemia, were selected and analyzed by direct sequencing of candidate genes. Two novel mutations in the mu heavy chain (muHC) gene (IGHM) were identified in three patients belonging to two unrelated families. A fourth patient carries a previously described G>A nucleotide substitution at the -1 position of an alternative splice site in IGHM; here, we demonstrate that this mutation is indeed responsible for aberrant splicing. Comparison of bone marrow cytofluorimetric profiles in two patients carrying different mutations in the IGHM gene suggests a genotype-phenotype correlation with the stage at which B-cell development is blocked. Several new single nucleotide polymorphisms (SNPs) both in the muHC and in the lambda5-like/VpreB-coding genes were identified. Two unrelated patients carry compound heterozygous variations in the VpreB1 gene that may be involved in disease ethiology. PMID:17410177

Ferrari, S; Zuntini, R; Lougaris, V; Soresina, A; Sourková, V; Fiorini, M; Martino, S; Rossi, P; Pietrogrande, M C; Martire, B; Spadaro, G; Cardinale, F; Cossu, F; Pierani, P; Quinti, I; Rossi, C; Plebani, A



Specific yield as determined by type-curve analysis of aquifer-test data  

USGS Publications Warehouse

The commonly used analytical solution developed by Neuman for a homogeneous, water-table aquifer assumes that the drainage of pores in the zone above the water table due to lowering of the water table occurs instantaneously. Noninstantaneous drainage of pores in the unsaturated zone accounts for the finding that both type-curve analysis and volume-balance calculations yield values of specific yield that are slightly less than those obtained from laboratory column-drainage experiments. It may also account for a slight underestimation of vertical hydraulic conductivity as obtained by type-curve analysis.

Moench, Allen, F.



Recessive mechanisms of malignancy.  

PubMed Central

It is increasingly recognised that recessive mutations play an important role in the pathogenesis of many forms of malignancy. Some of the affected loci may prove to be recessively-activated proto-oncogenes, but others are now known to be tumorigenic solely by virtue of their loss or inactivation and therefore form a distinct and novel family of tumour genes. Preliminary evidence suggests that such genes are likely to be functionally heterogeneous and to encode molecules involved in the inhibition of cellular proliferation and/or the induction of differentiation. Their further study is likely to illuminate fundamental mechanisms of normal cellular growth and differentiation as well as having important implications for the pathogenesis and management of cancer.

Green, A. R.



Analysis of Microindentation Unloading Curves based on Representative Strain Approach with Closed-Form Applications  

NASA Astrophysics Data System (ADS)

Indentation analysis based on the representative strain offers an effective way of obtaining material elastoplastic properties from the reverse analysis of indentation load-displacement curve. In this paper, its approach is employed to analyze the unloading force-depth curves obtained from a sharp microindentation test. By using the unloading work and residual penetration depth as parameters characterizing unloading, two different formulations of representative strain/stress are proposed, respectively, with very simple functional forms. When combined with the established framework of loading curves, the plastic properties and/or elastic properties of a material can be derived in closed-form using the loading curvature, unloading work, and residual depth measured from one sharp indentation test.

Ogasawara, Nagahisa; Chiba, Norimasa; Chen, Xi


Drainage-system development in consecutive melt seasons at a polythermal, Arctic glacier, evaluated by flow-recession analysis and linear-reservoir simulation  

NASA Astrophysics Data System (ADS)

The drainage systems of polythermal glaciers play an important role in high-latitude hydrology, and are determinants of ice flow rate. Flow-recession analysis and linear-reservoir simulation of runoff time series are here used to evaluate seasonal and inter-annual variability in the drainage system of the polythermal Finsterwalderbreen, Svalbard, in 1999 and 2000. Linear-flow recessions are pervasive, with mean coefficients of a fast reservoir varying from 16 (1999) to 41 h (2000), and mean coefficients of an intermittent, slow reservoir varying from 54 (1999) to 114 h (2000). Drainage-system efficiency is greater overall in the first of the two seasons, the simplest explanation of which is more rapid depletion of the snow cover. Reservoir coefficients generally decline during each season (at 0.22 h d-1 in 1999 and 0.52 h d-1 in 2000), denoting an increase in drainage efficiency. However, coefficients do not exhibit a consistent relationship with discharge. Finsterwalderbreen therefore appears to behave as an intermediate case between temperate glaciers and other polythermal glaciers with smaller proportions of temperate ice. Linear-reservoir runoff simulations exhibit limited sensitivity to a relatively wide range of reservoir coefficients, although the use of fixed coefficients in a spatially lumped model can generate significant subseasonal error. At Finsterwalderbreen, an ice-marginal channel with the characteristics of a fast reservoir, and a subglacial upwelling with the characteristics of a slow reservoir, both route meltwater to the terminus. This suggests that drainage-system components of significantly contrasting efficiencies can coexist spatially and temporally at polythermal glaciers.

Hodgkins, Richard; Cooper, Richard; Tranter, Martyn; Wadham, Jemma



Shear strength of horizontally curved steel I-girders — finite element analysis studies  

Microsoft Academic Search

This paper presents the results of finite element analysis (FEA) studies of four curved steel I-girder shear components tested experimentally in previous research, as well as parametric extensions of these tests. These studies focus on the influence of horizontal curvature on the maximum strength of transversely stiffened members with web slenderness D\\/tw approximately equal to the largest value permitted in

Se-Kwon Jung; Donald W. White



Computational Tools for Probing Interactions in Multiple Linear Regression, Multilevel Modeling, and Latent Curve Analysis  

Microsoft Academic Search

Simple slopes, regions of significance, and confidence bands are commonly used to evaluate interactions in multiple linear regression (MLR) models, and the use of these techniques has recently been extended to multilevel or hierarchical linear modeling (HLM) and latent curve analysis (LCA). However, conducting these tests and plotting the conditional relations is often a tedious and error-prone task. This article

Kristopher J. Preacher; Patrick J. Curran; Daniel J. Bauer



A Latent Growth Curve Analysis of Reading Achievement for an At-Risk Population  

ERIC Educational Resources Information Center

|The development of reading skills from age seven until age 19 was investigated for children who were referred for special education preschool intervention using latent growth curve analysis (n=206). Approximately one-third of the study sample did not require special education services after preschool, providing a natural comparison group. Reading…

Beecher, Constance C.



Analysis of horizontally curved post-tensioned segmental concrete box girder bridges  

Microsoft Academic Search

This report presents the background and details of a numerical procedure developed specifically for the longitudinal analysis of curved segmentally erected prestressed concrete box girder bridges. It is based on a skew ended thin-wall beam element including the modes of warping and distorsion of the cross section. The cross section must consist of a single cell, may have overhangs, and

Rafael Manuel Rojas



Computational Tools for Probing Interactions in Multiple Linear Regression, Multilevel Modeling, and Latent Curve Analysis  

ERIC Educational Resources Information Center

|Simple slopes, regions of significance, and confidence bands are commonly used to evaluate interactions in multiple linear regression (MLR) models, and the use of these techniques has recently been extended to multilevel or hierarchical linear modeling (HLM) and latent curve analysis (LCA). However, conducting these tests and plotting the…

Preacher, Kristopher J.; Curran, Patrick J.; Bauer, Daniel J.



Nonlinear analysis of a curved sandwich beam joined with a straight sandwich beam  

Microsoft Academic Search

The buckling behaviour of straight sandwich beams joined with curved sandwich beams loaded in pure bending is investigated using two different models. One is based on a high order sandwich beam theory and the other model is based on finite element analysis. The analyses are applied to a numerical example and the results are compared with experimental results.

Anders Lyckegaard; Ole Thybo Thomsen



Melting Curve Analysis for Rapid Detection of Topoisomerase Gene Mutations in Haemophilus influenzae?  

PubMed Central

We established a real-time PCR assay with melting curve analysis to rapidly genotype quinolone resistance-determining regions (QRDRs) of gyrase A and topoisomerase IV genes in Haemophilus influenzae. This assay is a useful tool for the detection of fluoroquinolone resistance and for the early detection of preexisting QRDR mutations.

Nakamura, Shigeki; Yanagihara, Katsunori; Morinaga, Yoshitomo; Izumikawa, Koichi; Seki, Masafumi; Kakeya, Hiroshi; Yamamoto, Yoshihiro; Kamihira, Shimeru; Kohno, Shigeru



Linearized limb-darkening coefficients for use in analysis of eclipsing binary light curves  

Microsoft Academic Search

Linear limb-darkening coefficientsu required in the analysis of eclipsing binary curves, are tabulated for a wide range of effective temperature (50 000° to 4000°), wavelength ? (0.2 µ=?=2.2 µ), and gravitiesg (2.0=logg=5.0). The computation is based on the comprehensive range of model atmospheres of Carbon and Gingerich (1969).

Hamid M. Al-Naimiy



The environmental Kuznets curve for deforestation: a threatened theory? A meta-analysis  

Microsoft Academic Search

Although widely studied, deforestation remains a topical and typical issue. The relationship between economic development and deforestation is still at stake. This paper presents a meta-analysis of Environmental Kuznets Curve (EKC) studies for deforestation. Using 71 studies, offering 631 estimations, we shed light on why EKC results differ. We investigate the incidence of choices made by authors (econometric strategy, deforestation

Johanna Choumert; Pascale Combes Motel; K. Herve DAKPO



Policy Effectiveness and the Slopes of IS and LM Curves: A Graphical Analysis.  

ERIC Educational Resources Information Center

Focuses on the IS-LM model providing a graphical analysis designed to clarify the confusion induced by misleading statements in several major macroeconomics textbooks concerning the connection between policy effectiveness and the slopes of the IS and LM curves. Includes references. (CMK)

Revier, Charles F.



Effects of variable recruitment on catch-curve analysis for crappie populations  

USGS Publications Warehouse

Catch-curve analysis is frequently used to estimate total annual mortality (A) of exploited fishes, but the method assumes constant recruitment. Because populations of crappie Pomoxis spp. have exhibited large fluctuations in recruitment, I conducted simulations to assess the amount of variability in recruitment that precludes the use of a catch curve and compared results to recruitment dynamics in six crappie populations. Coefficients of variation (CV = 100 ?? SD/mean) in recruitment to age 1 ranged from 55% to 84% among the six crappie populations. Simulations suggested that recruitment variability in these ranges would likely allow estimation of A within ?? 10%, but the probability of obtaining estimates of A that were ??5% or more of the true A would exceed 0.15. I suggest that catch curves may be used to approximate A in crappie populations but that managers should consider the effects on management recommendations if A were ??10% of the estimated A.

Allen, M. S.



Learning Factors Transfer Analysis: Using Learning Curve Analysis to Automatically Generate Domain Models  

ERIC Educational Resources Information Center

|This paper describes a novel method to create a quantitative model of an educational content domain of related practice item-types using learning curves. By using a pairwise test to search for the relationships between learning curves for these item-types, we show how the test results in a set of pairwise transfer relationships that can be…

Pavlik, Philip I. Jr.; Cen, Hao; Koedinger, Kenneth R.



ATWS Analysis with an Advanced Boiling Curve Approach within COBRA 3-CP  

SciTech Connect

In 2005 the German Reactor Safety Commission issued specific requirements on core coolability demonstration for PWR ATWS (anticipated transients without scram). Thereupon AREVA NP performed detailed analyses for all German PWRs. For a German KONVOI plant the results of an ATWS licensing analysis are presented. The plant dynamic behavior is calculated with NLOOP, while the hot channel analysis is performed with the thermal hydraulic computer code COBRA 3-CP. The application of the fuel rod model included in COBRA 3-CP is essential for this type of analysis. Since DNB (departure from nucleate boiling) occurs, the advanced post DNB model (advanced boiling curve approach) of COBRA 3-CP is used. The results are compared with those gained with the standard BEEST model. The analyzed ATWS case is the emergency power case 'loss of main heat sink with station service power supply unavailable'. Due to the decreasing coolant flow rate during the transient the core attains film boiling conditions. The results of the hot channel analysis strongly depend on the performance of the boiling curve model. The BEEST model is based on pool boiling conditions whereas typical PWR conditions - even in most transients - are characterized by forced flow for which the advanced boiling curve approach is particularly suitable. Compared with the BEEST model the advanced boiling curve approach in COBRA 3-CP yields earlier rewetting, i.e. a shorter period in film boiling. Consequently, the fuel rod cladding temperatures, that increase significantly due to film boiling, drop back earlier and the high temperature oxidation is significantly diminished. The Baker-Just-Correlation was used to calculate the value of equivalent cladding reacted (ECR), i.e. the reduction of cladding thickness due to corrosion throughout the transient. Based on the BEEST model the ECR value amounts to 0.4% whereas the advanced boiling curve only leads to an ECR value of 0.2%. Both values provide large margins to the 17% ECR limit. The maximum cladding temperature calculated with both models is almost identical. It results in approximately 830 deg. C, i.e. far below the embrittlement temperature (stipulated at 1200 deg. C). Core coolability was demonstrated with both models, with the BEEST model and with the advanced boiling curve approach. However, the advanced boiling curve approach results in more realistic values and reveals that a much higher safety margin exists. This advantage can be applied to all types of transient hot channel analyses which have to treat film boiling phases. (authors)

Gensler, A.; Knoll, A.; Kuehnel, K. [AREVA, AREVA NP GmbH, Freyeslebenstr. 1, D-91058 Erlangen (Germany)



High-Resolution Melting Curve Analysis for Rapid Detection of Rifampin Resistance in Mycobacterium tuberculosis: a Meta-Analysis.  


A rapid, simple, accurate, and affordable method for the detection of drug-resistant tuberculosis is very critical for the selection of antimicrobial therapy and management of patient treatment. High-resolution melting curve analysis has been used for the detection of rifampin resistance in Mycobacterium tuberculosis and has shown promise. We did a systematic review and meta-analysis of published studies to evaluate the accuracy of high-resolution melting curve analysis for the detection of rifampin resistance in clinical M. tuberculosis isolates. We searched the PubMed, BIOSIS Previews, and Web of Science databases to identify studies and included them according to predetermined criteria. We used the DerSimonian-Laird random-effects model to calculate pooled measures and applied Moses' constant for linear models to fit the summary receiver operating characteristic curve. According to the selection criteria, most of the identified studies were excluded, and only seven studies were included in the final analysis. The overall sensitivity of the high-resolution melting curve analysis was 94% (95% confidence interval [CI], 92% to 96%), and the overall specificity was very high at 99% (95% CI, 98% to 100%). The values for the pooled positive likelihood ratio, negative likelihood ratio, and diagnostic odds ratio were 63.39 (95% CI, 30.21 to 133.00), 0.06 (95% CI, 0.04 to 0.09), and 892.70 (95% CI, 385.50 to 2,067.24), respectively. There was no significant heterogeneity across all included studies for the measurements we evaluated. The summary receiver operating characteristic curve for the same data shows an area of 0.99 and a Q* value of 0.97. High-resolution melting curve analysis has high sensitivity and specificity for the detection of rifampin resistance in clinical M. tuberculosis isolates. This method might be a good alternative to conventional drug susceptibility tests in clinical practice. PMID:23885006

Yin, Xiaomao; Zheng, Lei; Liu, Qinlan; Lin, Li; Hu, Xiumei; Hu, Yanwei; Wang, Qian



GCAFIT—A new tool for glow curve analysis in thermoluminescence nanodosimetry  

NASA Astrophysics Data System (ADS)

Glow curve analysis is widely used for dosimetric studies and applications. Therefore, a new computer program, GCAFIT, for deconvoluting first-order kinetics thermoluminescence (TL) glow curves and evaluating the activation energy for each glow peak in the glow curve has been developed using the MATLAB technical computing language. A non-linear function describing a single glow peak is fitted to experimental points using the Levenberg-Marquardt least-square method. The developed GCAFIT software was used to analyze the glow curves of TLD-100, TLD-600, and TLD-700 nanodosimeters. The activation energy E obtained by the developed GCAFIT software was compared with that obtained by the peak shape methods of Grossweiner, Lushchik, and Halperin-Braner. The frequency factor S for each glow peak was also calculated. The standard deviations are discussed in each case and compared with those of other investigators. The results show that GCAFIT is capable of accurately analyzing first-order TL glow curves. Unlike other software programs, the developed GCAFIT software does not require activation energy as an input datum; in contrast, activation energy for each glow peak is given in the output data. The resolution of the experimental glow curve influences the results obtained by the GCAFIT software; as the resolution increases, the results obtained by the GCAFIT software become more accurate. The values of activation energy obtained by the developed GCAFIT software a in good agreement with those obtained by the peak shape methods. The agreement with the Halperin-Braner and Lushchik methods is better than with that of Grossweiner. High E and S values for peak 5 were observed; we believe that these values are not real because peak 5 may in fact consist of two or three unresolved peaks. We therefore treated E and S for peak 5 as an effective activation energy, Eeff, and an effective frequency factor, Seff. The temperature value for peak 5 was also treated as an effective quantity, Tm eff.

Abd El-Hafez, A. I.; Yasin, M. N.; Sadek, A. M.



Who Suffers during Recessions? NBER Working Paper No. 17951  

ERIC Educational Resources Information Center

|In this paper we examine how business cycles affect labor market outcomes in the United States. We conduct a detailed analysis of how cycles affect outcomes differentially across persons of differing age, education, race, and gender, and we compare the cyclical sensitivity during the Great Recession to that in the early 1980s recession. We…

Hoynes, Hilary W.; Miller, Douglas L.; Schaller, Jessamyn



Microarray-based mutation analysis of the ABCA4 (ABCR) gene in autosomal recessive cone–rod dystrophy and retinitis pigmentosa  

Microsoft Academic Search

Mutations in the ABCA4 gene have been associated with autosomal recessive Stargardt disease (STGD1), cone–rod dystrophy (CRD), and retinitis pigmentosa (RP). We employed a recently developed genotyping microarray, the ABCR400-chip, to search for known ABCA4 mutations in patients with isolated or autosomal recessive CRD (54 cases) or RP (90 cases). We performed detailed ophthalmologic examinations and identified at least one

B Jeroen Klevering; Suzanne Yzer; Klaus Rohrschneider; Marijke Zonneveld; Rando Allikmets; L Ingeborgh van den Born; Alessandra Maugeri; Carel B Hoyng; Frans PM Cremers; FPM Cremers



Recessed Lighting in the Limelight  

SciTech Connect

Recessed downlights are among the most popular installed lighting fixtures for new and remodeled homes. DOE estimates there are at least 350 million currently installed in US homes, and around 20 million are sold each year. A recent California study showed only 0.4 percent of recessed cans used compact fluorescent lamps. Annual reported sales of fluorescent residential recessed downlights nationwide make up no more than three percent of total residential recessed downlight sales. Standard recessed downlights waste energy by leaking conditioned air to unconditioned attic space, and using less efficient, high-heat incandescent bulbs. 33 states have adopted building codes that require recessed cans installed in the building shell to be airtight. To encourage lighting fixture manufacturers to bring to market high-efficiency air-tight recessed cans, DOE is sponsoring the recessed downlights project. PNNL solicited bids for energy efficient recessed downlights meeting the following specifications: They must use pin-based CFLs, have an airtight housing, be IC-rated, use electronic ballasts, and have a light output minimum of 900 initial lumens. PNNL did short- and long-term testing of the submitted lamps and negotiated lower prices for consumer purchase of qualifying models.

Gordon, Kelly L.; McCullough, Jeffrey J.



CT of the pericardial recesses  

SciTech Connect

Within the pericardial cavity there are several recesses where fluid can collect in close contiguity to the major bronchi and lymph nodes. These include the transverse sinus, behind the ascending aorta and pulmonary trunk; the oblique sinus, behind the left atrium; and the left pulmonic recess, between the left pulmonary artery and the left superior pulmonary vein. There are also smaller pericardial recesses between the superior and inferior pulmonary veins, posterolateral to the superior vena cava, and between the inferior vena cava and coronary sinus. An understanding of sectional anatomy is valuable for differentiation of fluid within these recesses from mediastinal masses or enlarged lymph nodes on computed tomographic scans.

Levy-Ravetch, M.; Auh, Y.H.; Rubenstein, W.A.; Whalen, J.P.; Kazam, E.



Analysis of the beverage data using cluster analysis, rotated principal components analysis and LOESS curves  

Microsoft Academic Search

In an attempt to determine what influences liking of the 28 beverages in the study, a combination of data analysis techniques was employed. While statistical rigor is an essential component of all sensory and consumer data analyses, these analyses would be remiss without the partnership of the expertise of both a sensory and statistical professional. This paper will discuss how

Frank Rossi; Alicia A Thomas



Thermo-XRD-analysis of montmorillonite treated with protonated Congo-red. Curve fitting  

Microsoft Academic Search

The adsorption of protonated Congo red (CR) by montmorillonite was investigated by thermo-XRD-analysis. Montmorillonite was loaded at pH 1 with increasing amounts of CR up to 75 mmol per 100 g clay. Diffractograms of samples treated at 420 °C showed broad peaks and were curve-fitted to determine the different basal spacings, which composed the XRD peaks. The broad peak of

Z. Yermiyahu; I. Lapides; S. Yariv



Re-Analysis of the Solar Phase Curves of the Icy Galilean Satellites  

Microsoft Academic Search

Re-analysis of the solar phase curves of the icy Galilean satellites demonstrates that the quantitative results are dependent on the single particle scattering function incorporated into the photometric model; however, the qualitative properties are independent. The results presented here show that the general physical characteristics predicted by a Hapke model (B. Hapke, 1986,Icarus67,264–280) incorporating a two parameter double Henyey–Greenstein scattering

Deborah Domingue; Anne Verbiscer



Computer-aided cooling curve analysis of A356 aluminum alloy  

Microsoft Academic Search

Computer aided cooling curve analysis (CA-CCA) is very useful in the foundry industry for easy and fast evaluation of a variety\\u000a of properties. Typical applications include the prediction of the temperatures and amounts of different phases appearing during\\u000a solidification and monitoring of the quality of melt in terms of Si- modification, grain refinement, inoculation, and graphite\\u000a spheoridization. The use of

Ihsan-ul-haq; Je-Sik Shin; Zin-Hyoung Lee



Molecular analysis of 250 patients with autosomal recessive congenital ichthyosis: evidence for mutation hotspots in ALOXE3 and allelic heterogeneity in ALOX12B.  


In recent years several new genes for autosomal recessive congenital ichthyosis (ARCI) have been identified. However, little is known about the molecular epidemiology and pathophysiology of this genetically and clinically heterogeneous group of severe disorders of keratinization. ARCI is characterized by intense scaling of the whole integument often associated with erythema. We and others have shown that mutations in ALOX12B and ALOXE3, coding for the lipoxygenases 12R-LOX and eLOX-3 predominantly synthesized in the epidermis, can underlie this rare condition. Here we have surveyed a large group of 250 patients with ARCI for mutations in these two genes. We have identified 11 different previously unreported mutations in ALOX12B and ALOXE3 in 21 ARCI patients from 19 unrelated families and demonstrated that mutations in the two genes are the second most common cause for ARCI in this cohort of patients. Examination of the molecular data revealed allelic heterogeneity for ALOX12B and two mutational hotspots in ALOXE3. Functional analysis of all missense mutations and a splice site mutation demonstrated that complete loss of function of the enzymes underlies the phenotype. Our findings further establish the pivotal role of the 12-lipoxygenase pathway during epidermal differentiation. PMID:19131948

Eckl, Katja-Martina; de Juanes, Silvia; Kurtenbach, Janine; Nätebus, Marc; Lugassy, Jenny; Oji, Vinzenz; Traupe, Heiko; Preil, Marie-Luise; Martínez, Francisco; Smolle, Josef; Harel, Avikam; Krieg, Peter; Sprecher, Eli; Hennies, Hans C



Autosomal recessive polycystic kidney disease  

Microsoft Academic Search

Autosomal recessive polycystic kidney disease is a rare inherited disorder which usually becomes clinically manifest in early childhood, whereas autosomal dominant polycystic kidney disease usually is a disorder of adult onset. With increasing knowledge and improving diagnostic techniques, it becomes evident that the spectrum of both entities is much more variable than generally known. The presentation of autosomal recessive polycystic

K. Zerres



CT of the pericardial recesses  

Microsoft Academic Search

Within the pericardial cavity there are several recesses where fluid can collect in close contiguity to the major bronchi and lymph nodes. These include the transverse sinus, behind the ascending aorta and pulmonary trunk; the oblique sinus, behind the left atrium; and the left pulmonic recess, between the left pulmonary artery and the left superior pulmonary vein. There are also

Miriam Levy-Ravetch; Yong Ho Auh; William A. Rubenstein; Joseph P. Whalen; Elias Kazam



A computerized glow curve analysis (GCA) method for WinREMS thermoluminescent dosimeter data using MATLAB.  


A computerized glow curve analysis (GCA) program for handling of thermoluminescence data originating from WinREMS is presented. The MATLAB program fits the glow peaks using the first-order kinetics model. Tested materials are LiF:Mg,Ti, CaF(2):Dy, CaF(2):Tm, CaF(2):Mn, LiF:Mg,Cu,P, and CaSO(4):Dy, with most having an average figure of merit (FOM) of 1.3% or less, with CaSO(4):Dy 2.2% or less. Output is a list of fit parameters, peak areas, and graphs for each fit, evaluating each glow curve in 1.5 s or less. PMID:21561783

Harvey, John A; Rodrigues, Miesher L; Kearfott, Kimberlee J



Genetic analysis of non-recessive factors of resistance to diazinon in the SKA strain of the housefly (Musca domestica L)*  

PubMed Central

The recent allocation of many visible mutants to specific linkage-groups has made possible their use as genetic markers in the study of the inheritance of insecticide resistance. In most organophosphorus-resistant strains, resistance is controlled by a single gene on the V linkage-group responsible for resistance and low ali-esterase activity, but in some strains more than one factor is present. The present work was done to analyse the genetics of resistance to diazinon in a strain (the SKA strain) bred from two diazinon-resistant strains. Crosses between the SKA flies and four susceptible recessive marker strains, each marked on one linkage-group, followed by test-crosses with recessive markers and by bioassays of each cross, have shown that non-recessive factors for resistance to diazinon are present on the IV and V linkage-groups. The SKA strain genetically resembles its parents but differs by being considerably more resistant.

Sawicki, R. M.; Franco, M. G.; Milani, R.



Gingival Recession: Review and Strategies in Treatment of Recession  

PubMed Central

One of the most common esthetic concerns associated with the periodontal tissues is gingival recession. Gingival recession is the exposure of root surfaces due to apical migration of the gingival tissue margins; gingival margin migrates apical to the cementoenamel junction. Although it rarely results in tooth loss, marginal tissue recession is associated with thermal and tactile sensitivity, esthetic complaints, and a tendency toward root caries. This paper reviews etiology, consequences, and the available surgical procedures for the coverage of exposed root surfaces, including three case reports.

Pradeep, Koppolu; Rajababu, Palaparthy; Satyanarayana, Durvasula; Sagar, Vidya



Consequence analysis to determine damage to buildings from vapour cloud explosions using characteristic curves.  


The objective of this paper is to propose a methodology to estimate the consequences to buildings from the pressure wave caused by unconfined vapour cloud explosions (VCEs). This methodology is based on the use of characteristic overpressure-impulse-distance curves, shown in a previous paper [F. Diaz Alonso, E. Gonzalez Ferradas, J.F. Sanchez Perez, A. Miñana Aznar, J. Ruiz Gimeno, J. Martinez Alonso, Characteristic overpressure-impulse-distance curves for vapour cloud, explosions using the TNO Multi-Energy model, J. Hazard. Mater. A137 (2006) 734-741]. They allow the overpressure and impulse at each distance from the explosion to be determined. Since they can be combined with damage criteria (such as those shown by the PROBIT equations), they can be used to perform consequence analysis as the damage is shown in the same diagram as the overpressure, impulse and distance. Since damages suffered by buildings usually affect people inside, it is important to take them into account when performing consequence analysis. This is done in this paper, where diagrams and equations are presented to determine minor damage to buildings (broken windows, displacement of doors and window frames, tile displacement, etc.), major structural damage (cracks in walls, collapse of some walls) and collapse (the damage is so extensive that the building is partially or totally demolished). This paper completes the consequence analysis to humans outdoors shown by F.D. Alonso et al. [F. Diaz Alonso, E. Gonzalez Ferradas, T. Jimenez Sanchez, A. Miñana Aznar, J. Ruiz Gimeno, J. Martinez Alonso, Consequence analysis to determine the damage to humans from vapour cloud explosions using characteristic curves, J. Hazard. Mater., in press]. PMID:18367326

Alonso, Fernando Díaz; Ferradás, Enrique González; Pérez, Juan Francisco Sánchez; Aznar, Agustín Miñana; Gimeno, José Ruiz; Miñarro, Marta Doval



Analysis of pendulum-structure influencing on guidance systm for high-speed Maglev train running on curve  

Microsoft Academic Search

For Analysis of curve-running performances and influencing factors of maglev guidance system. This paper is based on double bogies system and investigates influences of pendulum-structure when system running on the curve. Firstly, system structure and simplification conditions are described. Secondly, dynamics model of carriage and kinematics model of bogies have been set up. Thirdly, formulas of movement and pulling forces

Chunxia Zhao; Longhua She; Wensen Chang



A new explanation for recessive myotonia congenita  

PubMed Central

Objective: To assess whether exon deletions or duplications in CLCN1 are associated with recessive myotonia congenita (MC). Methods: We performed detailed clinical and electrophysiologic characterization in 60 patients with phenotypes consistent with MC. DNA sequencing of CLCN1 followed by multiplex ligation-dependent probe amplification to screen for exon copy number variation was undertaken in all patients. Results: Exon deletions or duplications in CLCN1 were identified in 6% of patients with MC. Half had heterozygous exonic rearrangements. The other 2 patients (50%), with severe disabling infantile onset myotonia, were identified with both a homozygous mutation, Pro744Thr, which functional electrophysiology studies suggested was nonpathogenic, and a triplication/homozygous duplication involving exons 8–14, suggesting an explanation for the severe phenotype. Conclusions: These data indicate that copy number variation in CLCN1 may be an important cause of recessive MC. Our observations suggest that it is important to check for exon deletions and duplications as part of the genetic analysis of patients with recessive MC, especially in patients in whom sequencing identifies no mutations or only a single recessive mutation. These results also indicate that additional, as yet unidentified, genetic mechanisms account for cases not currently explained by either CLCN1 point mutations or exonic deletions or duplications.

Raja Rayan, D.L.; Haworth, A.; Sud, R.; Matthews, E.; Fialho, D.; Burge, J.; Portaro, S.; Schorge, S.; Tuin, K.; Lunt, P.; McEntagart, M.; Toscano, A.; Davis, M.B.



Pg 1115+080: New Analysis of the Light Curves Confirms Old Time Delay Results  

NASA Astrophysics Data System (ADS)

We analyzed all publicly available long-term optical observations of the gravitationally lensed quasar PG1115+080 with the aim of measuring the time delays between its four components. In particular, we presented analysis of the Maidanak light curves of the PG1115+080 components, obtained between 2001 and 2006 (Tsvetkova et al. 2010). We found that the light curves of the 2006 observational season show almost linear trend with some fast variations seen only in the A1 and C components. That can be both due to microlensing or observational errors. Those fast variations can decrease statistical significance of the time delay estimates or even produce misleading results. Application of the MCCF technique (Oknyanskij 1993) to photometric data collected in the 2004-2005 seasons gives time delay values tBC = 22±;3, tAC = 12±3, and tBA = 10±3 days, which are in agreement with previous results of Schechter et al. (1997) and Barkana (1997) reported for the 1995-1996 light curves analyzed using two different statistical methods. The ratio tAC/tBA between our intermediate delays is about 1.2, that is close to the value reported by Barkana ( ˜1.13) and predicted by lens models (˜1.4) unlike the Schechter's and Vakulik's (2009) values (˜ 0.7 and ˜2.7).

Artamonov, B.; Koptelova, E.; Oknyanskij, V.; Shimanovskaya, E.


Kinematic analysis of the technique for elite male long-distance speed skaters in curving.  


The purpose of this study was to investigate technical factors for maintaining skating velocity by kinematic analysis of the skating motion for elite long-distance skaters during the curve phase in official championship races. Sixteen world-class elite male skaters who participated in the 5,000-m race were videotaped with two synchronized high-speed video cameras (250 Hz) in a curve lane by using a panning DLT technique. Three-dimensional coordinates of the body and blades during the first and second halves of the races were collected to calculate kinematic parameters. In the group that maintained greater skating velocity, the thigh angle during the gliding phase of the left stroke during the second half was greater than that during the first half, and the center of mass was located more forward during the second half. Thus, it was suggested that long-distance speed skaters should change the support leg position during the gliding phase in the left stroke of the curve phase under fatigued conditions so that they could extend the support leg with a forward rotation of the thigh and less shank backward rotation. PMID:17603132

Juda, Jun; Yuki, Masahiro; Aoyanagi, Toru; Fujii, Norihisa; Ae, Michiyoshi



Receiver Operating Characteristic Curve Analysis of Beach Water Quality Indicator Variables  

PubMed Central

Receiver operating characteristic (ROC) curve analysis is a simple and effective means to compare the accuracies of indicator variables of bacterial beach water quality. The indicator variables examined in this study were previous day's Enterococcus density and antecedent rainfall at 24, 48, and 96 h. Daily Enterococcus densities and 15-min rainfall values were collected during a 5-year (1996 to 2000) study of four Boston Harbor beaches. The indicator variables were assessed for their ability to correctly classify water as suitable or unsuitable for swimming at a maximum threshold Enterococcus density of 104 CFU/100 ml. Sensitivity and specificity values were determined for each unique previous day's Enterococcus density and antecedent rainfall volume and used to construct ROC curves. The area under the ROC curve was used to compare the accuracies of the indicator variables. Twenty-four-hour antecedent rainfall classified elevated Enterococcus densities more accurately than previous day's Enterococcus density (P = 0.079). An empirically derived threshold for 48-h antecedent rainfall, corresponding to a sensitivity of 0.75, was determined from the 1996 to 2000 data and evaluated to ascertain if the threshold would produce a 0.75 sensitivity with independent water quality data collected in 2001 from the same beaches.

Morrison, Ann Michelle; Coughlin, Kelly; Shine, James P.; Coull, Brent A.; Rex, Andrea C.



CYP2C19 progress curve analysis and mechanism-based inactivation by three methylenedioxyphenyl compounds.  


Several in vitro criteria were used to assess whether three methylenedioxyphenyl (MDP) compounds, the isoquinoline alkaloids bulbocapnine, canadine, and protopine, are mechanism-based inactivators of CYP2C19. The recently reported fluorometric CYP2C19 progress curve analysis approach was applied first to determine whether these alkaloids demonstrate time-dependent inhibition. In this experiment, bulbocapnine, canadine, and protopine displayed time dependence and saturation in their inactivation kinetics with K(I) and k(inact) values of 72.4 ± 14.7 ?M and 0.38 ± 0.036 min(-1), 2.1 ± 0.63 ?M and 0.18 ± 0.015 min(-1), and 7.1 ± 2.3 ?M and 0.24 ± 0.021 min(-1), respectively. Additional studies were performed to determine whether other specific criteria for mechanism-based inactivation were fulfilled: NADPH dependence, irreversibility, and involvement of a catalytic step in the enzyme inactivation. CYP2C19 activity was not significantly restored by dialysis when it had been inactivated by the alkaloids in the presence of a NADPH-regenerating system, and a metabolic-intermediate complex-associated increase in absorbance at approximately 455 nm was observed. In conclusion, the CYP2C19 progress curve analysis method revealed time-dependent inhibition by these alkaloids, and additional experiments confirmed its quasi-irreversible nature. This study revealed that the CYP2C19 progress curve analysis method is useful for identifying novel mechanism-based inactivators and yields a wealth of information in one run. The alkaloids bulbocapnine, canadine, and protopine, present in herbal medicines, are new mechanism-based inactivators and the first MDP compounds exhibiting quasi-irreversible inactivation of CYP2C19. PMID:21908684

Salminen, Kaisa A; Meyer, Achim; Imming, Peter; Raunio, Hannu



Analysis of multicolour light curves of the eclipsing binaries AQ Tuc and AY Vel  

NASA Astrophysics Data System (ADS)

First multicolour photoelectric light curves of the eclipsing binaries AQ Tuc and AY Vel obtained in 1965 and 1969 at the Leiden Southern Station using Walraven VBLU filters were analyzed by the Wilson-Devinney's code. Our analysis confirmed the contact configuration for AQ Tuc and revealed that AY Vel is an almost contact system with q approx. 3. The absolute radii of the components of AQ Tuc derived from the combination of our photometric and available spectroscopic elements are R1 = 2.03 +/- 0.11 RSun and R2 = 1.30 +/- 0.07 RSun.

Chochol, D.; van Houten, C. J.; Pribulla, T.; Grygar, J.



Analysis of a Curved Interfacial Crack Between Viscoelastic Foam and Anisotropic Composites Under Antiplane Shear  

NASA Astrophysics Data System (ADS)

The analysis of curved interfacial crack between viscoelastic foam and anisotropic composites was conducted under antiplane shear loading applied at infinity. In the analysis, in order to represent viscoelastic behavior of foam, the Kelvin-Maxwell model was incorporated and Laplace transform was applied to treat the viscoelastic characteristics of foam. The curved interfacial crack problem was reduced to a Hilbert problem and a closed-form asymptotic solution was derived. The stress intensity factors in the vicinity of the interfacial crack tip were predicted by considering both anisotropic characteristics of composites and viscoelastic properties of foam. It was found from the analysis that the stress intensity factor was governed by material properties such as shear modulus and relaxation time, and increased with the increase in the curvature as well as the ratio of stiffness coefficients of composite materials. It was also observed that the effect of fiber orientation in the composite materials on the stress intensity factor decreased with the increase in the difference in stiffness coefficients between foam and composite.

Chun, Heoung Jae; Park, Sang Hyun


On the Analysis and Construction of the Butterfly Curve Using "Mathematica"[R  

ERIC Educational Resources Information Center

|The butterfly curve was introduced by Temple H. Fay in 1989 and defined by the polar curve r = e[superscript cos theta] minus 2 cos 4 theta plus sin[superscript 5] (theta divided by 12). In this article, we develop the mathematical model of the butterfly curve and analyse its geometric properties. In addition, we draw the butterfly curve and…

Geum, Y. H.; Kim, Y. I.



Evidence of genetic heterogeneity in the autosomal recessive adult forms of limb-girdle muscular dystrophy following linkage analysis with 15q probes in Brazilian families  

Microsoft Academic Search

The autosomal recessive limb-girdle muscular dystrophies (LGMD) represent a heterogeneous group of diseases which may be characterised by one or more autosomal loci. A gene at 15q has recently been found to be responsible for a mild form of LGMD in a group of families from the isolated island of Réunion, now classified as LGMD2. Based on results of eight

M R Passos-Bueno; I Richard; M Vainzof; F Fougerousse; J Weissenbach; O Broux; D Cohen; J Akiyama; S K Marie; A A Carvalho



Dynamical x-ray diffraction from nonuniform crystalline films: Application to x-ray rocking curve analysis  

Microsoft Academic Search

A dynamical model for the general case of Bragg x-ray diffraction from arbitrarily thick nonuniform crystalline films is presented. The model incorporates depth-dependent strain and a spherically symmetric Gaussian distribution of randomly displaced atoms and can be applied to the rocking curve analysis of ion-damaged single crystals and strained layer superlattices. The analysis of x-ray rocking curves using this model

C. R. Wie; T. A. Tombrello; T. Vreeland Jr.



Differentiation of infectious bursal disease virus strains using real-time RT-PCR and high resolution melt curve analysis  

Microsoft Academic Search

Differentiation of infectious bursal disease virus (IBDV) strains is crucial for effective vaccination programs and epidemiological investigations. In this study, a combination of real-time RT-PCR and high resolution melt (HRM) curve analysis was developed for simultaneous detection and differentiation of IBDV strains\\/isolates. The hypervariable region of VP2 gene was amplified from several IBDV strains and subjected to HRM curve analysis.

Seyed A. Ghorashi; Denise O’Rourke; Jagoda Ignjatovic; Amir H. Noormohammadi



Predicting the in-situ stress state for deep wells using differential strain curve analysis  

SciTech Connect

Recent developments in energy exploration at depths of 5000 to 25,000 ft have made it necessary to quickly and reliably determine the in situ stresses acting on the well bore. Differential strain analysis (DSA) is being investigated as a technique applied to core samples to indirectly determine the in situ stress state. Testing is being pursued in 3 steps. First, field measurements of strain are made in situ as the core is pulled out of the well. Second, the cores are brought to the lab and DSA is performed under in situ hydrostatic conditions. Third, the rock is examined microscopically. It appears favorable that a reasonably accurate estimate of the 3-dimensional stress state can be obtained using the strain curve analysis method. 12 references.

Strickland, F.G.; Ren, N.K.



Photometric Light Curve Analysis of RV Tauri Stars Using AAVSO Data  

NASA Astrophysics Data System (ADS)

In order to gain a better understanding of the pulsating phenomenon that is characteristic to RV Tauri and Semi-Regular stars, we are using the least squares method, fourier analysis and the weighted wavelet analysis techniques to create model light curve fits for several RV and SR type variables. We began by downloading raw data for each variable from the AAVSO International Database and by using the aforementioned techniques, we are able to determine the dominate formal and half periods for each star, and track their stability over time. We will present our current progress and preliminary results for our multi-periodic fits and their variation over time focusing on the seven year period from 2002 through 2009. Support for this work was provided by the NSF PAARE program to South Carolina State University under award AST-0750814.

Nesmith, Eva; Cash, J.



Efficient broken line fitting procedure for analysis of force spectroscopy curves in chemical force microscopy  

NASA Astrophysics Data System (ADS)

The procedure for the analysis of force-distance curves in chemical force microscopy is presented. This procedure is based upon the Broken Line Fitting algorithm with an adaptation of knots positions. The strength of this method relies on the fact that it has O(N) complexity, which means that it is as efficient as standard peak detection techniques utilized by commercially available software. It is shown by means of computer simulations that the algorithm is able to detect snap-out points of a height comparable to a noise level, which is a significant improvement in comparison to previously reported techniques. The proposed method is also resistant to base line distortions. Using this procedure for an analysis of CH3-CH3 interactions enabled measurements of interactions between only two molecules, which has been confirmed experimentally. The obtained results strongly support validity of the Johnson-Kendall-Roberts model at the sub-nanometer scale.

Jó?wiak, G.; Masalska, A.; Gotszalk, T.; Schroeder, G.



Z curve theory-based analysis of the dynamic nature of nucleosome positioning in Saccharomyces cerevisiae.  


Nucleosome is the elementary structural unit of eukaryotic chromatin. Instability of nucleosome positioning plays critical roles in chromatin remodeling in differentiation and disease. In this study, we investigated nucleosome dynamics in the Saccharomyces cerevisiae genome using a geometric model based on Z curve theory. We identified 52,941 stable nucleosomes and 7607 dynamic nucleosomes, compiling them into a genome-wide nucleosome dynamic positioning map and constructing a user-friendly visualization platform ( Our approach achieved a sensitivity of 90.31% and a specificity of 87.76% for S. cerevisiae. Analysis revealed transcription factor binding sites (TFBSs) were enriched in linkers. And among the sparse nucleosomes around TFBSs, dynamic nucleosomes were slightly preferred. Gene Ontology (GO) enrichment analysis indicated that stable and dynamic nucleosomes were enriched on genes involved in different biological processes and functions. This study provides an approach for comprehending chromatin remodeling and transcriptional regulation of genes. PMID:23958656

Wu, Xueting; Liu, Hui; Liu, Hongbo; Su, Jianzhong; Lv, Jie; Cui, Ying; Wang, Fang; Zhang, Yan



Computer Program for Predicting Recharge with a Master Recession Curve.  

National Technical Information Service (NTIS)

Water-table fluctuations occur in unconfined aquifers owing to ground-water recharge following precipitation and infiltration, and ground-water discharge to streams between storm events. Ground-water recharge can be estimated from well hydrograph data usi...

C. S. Heppner J. R. Nimmo



Trabeculectomy with mitomycin C in the treatment of post-traumatic angle recession glaucoma  

PubMed Central

AIM—The presence of traumatic angle recession is a risk factor for failure of glaucoma filtration surgery and a previous study has suggested that antimetabolite treatment should be used in these patients. This study was undertaken to determine for the first time the mid term results of trabeculectomy with intraoperative application of mitomycin C in patients with post-traumatic angle recession glaucoma.?METHODS—A retrospective analysis was made of 43 consecutive trabeculectomy procedures in 41 young black/mixed race patients followed for a mean period of 25 months (range 2-66 months). Mitomycin C 0.02% was applied between the sclera and conjunctiva for 1-5 minutes at the time of surgery. The intraocular pressure and visual acuity were measured postoperatively. The success of this technique was analysed by using a Kaplan-Meier cumulative survival curve.?RESULTS—The intraocular pressure was successfully controlled at last follow up without topical treatment in 77% (33/43 eyes) and the visual acuity was the same or better in 81% (35/43 eyes). Cumulative probability of success was 85% at 1 year follow up, 81% at 2 years, and 66% at 3 years and thereafter. Hypotonous maculopathy occurred in one patient and no cases of late bleb infection were found.?CONCLUSIONS—In medically uncontrolled post-traumatic angle recession glaucoma trabeculectomy with mitomycin C is an effective surgical procedure with an acceptable complication rate. Good intraocular pressure control and preservation of vision can be expected in most patients.??

Manners, T; Salmon, J; Barron, A; Willies, C; Murray, A



Analysis of the Turbulent Regime of the Progress Curve when New Learning Additions Have Variable Slopes.  

National Technical Information Service (NTIS)

Learning curves have been used extensively for predictive purposes in the airframe and other industries. In many instances this has led to erroneous results because analysts failed to extend learning curve theory and develop adequate analytical techniques...

P. M. James



Convex constraint analysis: a natural deconvolution of circular dichroism curves of proteins.  


A new algorithm, called convex constraint analysis, has been developed to deduce the chiral contribution of the common secondary structures directly from experimental CD curves of a large number of proteins. The analysis is based on CD data reported by Yang, J.T., Wu, C.-S.C. and Martinez, H.M. [Methods Enzymol., 130, 208-269 (1986)]. Application of the decomposition algorithm for simulated protein data sets resulted in component spectra [B (lambda, i)] identical to the originals and weights [C (i, k)] with excellent Pearson correlation coefficients (R) [Chang, C.T., Wu, C.-S.C. and Yang, J.T. (1978) Anal. Biochem., 91, 12-31]. Test runs were performed on sets of simulated protein spectra created by the Monte Carlo technique using poly-L-lysine-based pure component spectra. The significant correlational coefficients (R greater than 0.9) demonstrated the high power of the algorithm. The algorithm, applied to globular protein data, independent of X-ray data, revealed that the CD spectrum of a given protein is composed of at least four independent sources of chirality. Three of the computed component curves show remarkable resemblance to the CD spectra of known protein secondary structures. This approach yields a significant improvement in secondary structural evaluations when compared with previous methods, as compared with X-ray data, and yields a realistic set of pure component spectra. The new method is a useful tool not only in analyzing CD spectra of globular proteins but also has the potential for the analysis of integral membrane proteins. PMID:1946324

Perczel, A; Hollósi, M; Tusnády, G; Fasman, G D



First Quintuplet Frequency Solution of a Blazhko Variable: Light Curve Analysis of RV UMa  

NASA Astrophysics Data System (ADS)

RV UMa is one of the RRab stars showing regular large-amplitude light-curve modulation. Extended photoelectric observations of RV UMa obtained at the Konkoly Observatory were published by Kanyó, and the data were analysed by Kovács. After detecting an error in the reduction procedure of the published Konkoly data, corrected photometric data are presented with additional, previously unpublished measurements. The re-analysis of the combination of the corrected Konkoly data supplemented by Preston & Spinrad's observations has led to the discovery that the appropriate mathematical model of the light curve is, in fact, a quintuplet frequency solution, rather than, a triplet. This finding has crucial importance in the interpretation of the Blazhko phenomenon, as a triplet (doublet) is the preferred structure in resonance models, quintuplet in magnetic models. Period changes of both the pulsation and modulation light variations of RV UMa have been detected based on its century-long photometric observations. An overall anticorrelation between the pulsation and modulation period changes can be defined by dPBl /dP 0 = -8.6 × 104 gradient, i.e., the modulation period is longer if the pulsation period is shorter. Between 1946 and 1975 the pulsation and modulation periods showed, however, parallel changes, which points to the fact that there is no strict relation between the changes in the periods of the pulsation and modulation.

Hurta, Zs.; Jurcsik, J.; Szeidl, B.; Sódor, Á.



Type Curve Analysis of Inertial Effects in the Response of a Well to a Slug Test  

NASA Astrophysics Data System (ADS)

The water level response to a slug or bailer test in a well completed in a confined aquifer has been evaluated taking into account well-bore storage and inertial effects of the water column in the well. The response range, from overdamped with negligible inertial effects to damped oscillation, was covered employing numerical inversions of the Laplace-transform solution. By scaling the time with respect to the undamped natural period of the well-aquifer system and by using the damping parameter for a second-order damped, inertial-elastic system, a set of type curves was constructed that enables water level response data from a slug or bailer test to be analyzed under conditions where the inertial parameter is large. Values of transmissivity and effective static water column length can be determined when an estimate of storage coefficient is available. The numerical solution and resulting type curves cover the transition range between the limiting cases of negligible inertial effects and of damped oscillation that have been treated by others. Two examples of slug test analysis show that precise results depend on accurate measurements of water level displacement (±1% of initial value).

Kipp, Kenneth L., Jr.



Clinical features and [ 11 C]CFT PET analysis of PARK2, PARK6, PARK7-linked autosomal recessive early onset Parkinsonism  

Microsoft Academic Search

Mutations in the Parkin, PINK1, and DJ-1 genes can cause autosomal recessive early onset Parkinsonism. We studied three families with the mutations of the Parkin, PINK1 and DJ-1 genes, respectively, with a dopamine transporter ligand [11C]-CFT positron emission tomography. A marked bilaterally and dissymmetrically decrement of [11C]-CFT uptake was found in all these patients, and putamen as well as caudate

Ji-feng GuoLei; Lei Wang; Dan He; Qiao-hong Ou Yang; Zhong-xiang Duan; Xue-wei Zhang; Li-luo Nie; Xin-xiang Yan; Bei-sha Tang



Development and analysis of vehicle trajectories and speed profiles along horizontal curves  

Microsoft Academic Search

Vehicle crashes at horizontal curves account for 42 percent of lane departure crashes on roadways. The risks of crashes on horizontal curves have been reported to be about 1.4 to 5 times greater than that for tangent sections. Twenty-five percent of the total number of fatal crashes in the United States occurred on horizontal curves. Driver error due to situational

Eric John Fitzsimmons



Rapid prototyping and performance analysis of elliptic curve cryptographic algorithms using Java and Maple  

Microsoft Academic Search

Elliptic Curve Cryptography is an increasingly popular method of public key cryptography. It is important that these systems are made as secure as possible to known attacks. The determination of the number of points on a given elliptic curve is central to establishing whether it i s an appropriately secure curve to use. This paper describes the design, implementation and

Andrew Burnett; Tom Dowling



Finite element analysis of the effect of loading curve shape on brain injury predictors.  


Prediction of traumatic and mild traumatic brain injury is an important factor in managing their prevention. Currently, the prediction of these injuries is limited to peak linear and angular acceleration loading curves derived from laboratory reconstructions. However it remains unclear as to what aspect of these loading curves contributes to brain tissue damage. This research uses the University College Dublin Brain Trauma Model (UCDBTM) to analyse three distinct loading curve shapes meant to represent different helmet loading scenarios. The loading curves were applied independently in each axis of linear and angular acceleration and their effect on currently used predictors of TBI and mTBI was examined. Loading curve shape A had a late time to peak, B an early time to peak and C had a consistent plateau. The areas under the curve for all three loading curve shapes were identical. The results indicate that loading curve A produced consistently higher maximum principal strains and Von Mises stress than the other two loading curve types. Loading curve C consistently produced the lowest values of maximum principal strain and Von Mises stress, with loading curve B being lowest in only 2 cases. The areas of peak Von Mises stress and Principal strain also varied depending on loading curve shape and acceleration input. PMID:22239921

Post, Andrew; Hoshizaki, Blaine; Gilchrist, Michael D



Correlation Analysis of Optical and Radio Light Curves for a Large Sample of Active Galactic Nuclei  

NASA Astrophysics Data System (ADS)

The Rosemary Hill Observatory has accumulated internally consistent light curves extending over as much as 26 years for a large sample of active galactic nuclei. Forty-six of these optical records have been compared with similar radio records from the University of Michigan Radio Astronomy Observatory and the Algonquin Radio Observatory. For 18 objects, pairs of records were sufficiently long and unconfused to allow reliable application of the Discrete Correlation Function analysis; this group included 8 BL Lacertids, 8 quasars, and 2 Seyfert galaxies. Nine of the 18 sources showed positive radio-optical correlations, with the radio events lagging the optical by intervals ranging from 0 to 14 months. Consistent with the relativistic beaming model of the BL Lacertids, the group displaying correlations was dominated by this type of object.

Clements, S. D.; Smith, A. G.; Aller, H. D.; Aller, M. F.



Analysis of H2 clearance curves used to measure blood flow in rat sciatic nerve.  

PubMed Central

1. By use of the H2 clearance technique, blood flow was measured in the sciatic nerve of healthy, anaesthetized Sprague-Dawley rats at rest, during inferior vena cava occlusion and during 5-hydroxytryptamine infusion. The purpose was to clarify the mechanisms underlying the biexponential curves which are commonly obtained using this technique. 2. An analysis of the frequency distribution of rate constants of 270 nerve and thirty-three arterial samples indicated that H2 clearance rates cluster below 20 ml min-1 100 g-1 and between 70 and 100 ml min-1 100 g-1. This suggests that at least two compartments are present. 3. The contribution of diffusion was studied by recording H2 clearance immediately following circulatory arrest. Slow clearance rates (median = 2.4 ml min-1 100 g-1) were observed, indicating that diffusion is not likely to contribute significantly to nutritive flow under most situations. 4. The contribution of arteriovenous shunts to H2 clearance was assessed by determining H2 clearance during inferior vena cava occlusion and the infusion of 5-hydroxytryptamine. Both manoeuvres caused abolition of, or a significant reduction in the weight of, the fast component which indicates that this compartment is closely related to arteriovenous shunts in nerve. 5. By use of a multi-compartmental model, it was shown that H2 clearance should follow a multi-exponential course, where the weights of the components reflect the relative volumes of each compartment and the exponents represent the relative flow (i.e. flow per unit volume) in each compartment. 6. By use of other mathematical models, estimates were made for the clearance rates attributable to polarographic oxidation of H2 at the tip of the microelectrode (0.2 ml min-1 100 g-1) and to diffusion to air (2 ml min-1 100 g-1). The latter estimate is very close to the measured value of 2.4 ml min-1 100 g-1. 7. These findings indicate that it is possible to separately assess nutritive and non-nutritive flow by application of biexponential analysis to H2 clearance curves. The data suggest that the fast component of a H2 clearance curve is closely associated with arteriovenous shunts, while the slower component is likely to represent capillary flow. Processes such as diffusion to air or oxidation of H2 by the electrode are very slow and therefore are unlikely to distort the assessment of blood flow by using this technique. Images Fig. 7

Day, T J; Lagerlund, T D; Low, P A



Characterization of individual rock magnetic components by analysis of remanence curves.  

NASA Astrophysics Data System (ADS)

The characterization of individual magnetic components in sediments and sedimentary rocks is difficult, as these natural materials are often a complex mixture of magnetic mineral sources. The analysis of magnetization curves with model functions is the only practicable method of unmixing the magnetic components and characterizing their magnetic properties, if a priori information is not available. Unfortunately, such analyses rely on time consuming measurements and on the choice of appropriate model functions. The simplification of the unmixing problem is closely related to the number of parameters required to fully characterize a magnetic component, and the significance of these parameters in rock magnetic terms. A systematic analysis of synthetic and natural samples shows that a combination of four parameters, here called magnetic fingerprints, is sufficient for this purpose. The fingerprints of individual magnetic components isolated from a wide range of natural sediments and sedimentary rocks form well-defined groups with specific properties. These groups reflect common processes of formation, transport and dissolution of magnetic particles. A clear distinction can be made between two sorts of biogenic magnetite, atmospheric dust, urban pollution and ultrafine magnetite produced in soils and lacustrine/marine sediments.

Egli, R.


Autosomal recessive polycystic kidney disease  

Microsoft Academic Search

The clinical features of 55 cases of autosomal recessive polycystic kidney disease (ARPCKD) have been reviewed. Each had evidence of ARPCKD. The outcomes of 87% were known; 24 had died. Twenty-four of 31 were seen between 1980 and 1986; 7 could not be traced. Forty-five percent presented under 1 month; 38% between 1 month and 1 year; and 9 cases

Bernard S. Kaplan; J. Fay; Vanita Shah; Michael J. Dillon; T. Martin Barratt



Autosomal recessive polycystic kidney disease  

Microsoft Academic Search

Recessive type or infantile polycystic kidney disease is an inherited disorder with cystic dilatations of the collecting ducts frequently associated with hepatic involvement, consisting of biliary dysgenesis and periportal fibrosis . The gene responsible for the disease, PKHD1, located on the short arm of chromosome 6, has recently been identified. It contains more than 80 exons and codes for a

Patrick Niaudet



Urban unemployment in the recession  

Microsoft Academic Search

At the start of the 2008 recession, many assumed that the worst hit sector would be financial services, and so the impact would fall on the affluent in London and the South. Yet more recent descriptive analyses have suggested that unemployment increases have in fact been largest in the West Midlands and in areas dominated by manufacturing employment (Clayton 2009;

Neil Lee


Algebra, Home Mortgages, and Recessions  

ERIC Educational Resources Information Center

The current financial crisis and recession in the United States present an opportunity to discuss relevant applications of some topics in typical first-and second-year algebra and precalculus courses. Real-world applications of percent change, exponential functions, and sums of finite geometric sequences can help students understand the problems…

Mariner, Jean A. Miller; Miller, Richard A.



Microarray analysis shows that recessive resistance to Watermelon mosaic virus in melon is associated with the induction of defense response genes.  


Resistance to Watermelon mosaic virus (WMV) in melon (Cucumis melo L.) accession TGR-1551 is characterized by a significant reduction in virus titer, and is inherited as a recessive, loss-of-susceptibility allele. We measured virus RNA accumulation in TGR-1551 plants and a susceptible control ('Tendral') by real-time quantitative polymerase chain reaction, and also profiled the expression of 17,443 unigenes represented on a melon microarray over a 15-day time course. The virus accumulated to higher levels in cotyledons of the resistant variety up to 9 days postinoculation (dpi) but, thereafter, levels increased in the susceptible variety while those in the resistant variety declined. Microarray experiments looking at the early response to infection (1 and 3 dpi), as well as responses after 7 and 15 dpi, revealed more profound transcriptomic changes in resistant plants than susceptible ones. The gene expression profiles revealed deep and extensive transcriptome remodeling in TGR-1551 plants, often involving genes with pathogen response functions. Overall, our data suggested that resistance to WMV in TGR-1551 melon plants is associated with a defense response, which contrasts with the recessive nature of the resistance trait. PMID:21970693

Gonzalez-Ibeas, Daniel; Cañizares, Joaquin; Aranda, Miguel A



An observational analysis of the late light curves of normal type Ia supernovae  

Microsoft Academic Search

Type Ia supernovae, thought to be the thermonuclear explosions of white dwarf stars in binary systems; are important astronomical objects having application in many areas of astrophysics. The light curves of Type Ia supernovae are powered by the products of the 56 Ni [arrow right] 56 Co [arrow right] 56 Fe decay, with the late time light curve being powered

Jessica Crist Lair



Equations for the analysis of the light curves of extra-solar planetary transits  

Microsoft Academic Search

Easy to use analytical formulae are presented for the computation the of light curves of extra-solar planetary transits. The equations are a function of the fractional radii of the planet and the parent star, the inclination of the orbit, and the limb-darkening coefficients of the star. Light curves can be solved for these parameters depending on the precision of the

A. Giménez



Technology S-curves in renewable energy alternatives: Analysis and implications for industry and government  

Microsoft Academic Search

Plotting the performance of a technology against the money or effort invested in it most often yields an S-shaped curve: slow initial improvement, then accelerated improvement, then diminishing improvement. These S-curves can be used to gain insight into the relative payoff of investment in competing technologies, as well as providing some insight into when and why some technologies overtake others

Melissa A. Schilling; Melissa Esmundo



Failure analysis of curved composite panels based on first-ply and buckling failures  

Microsoft Academic Search

Curved panels are used extensively in several branches of engineering and in particular in marine and aerospace engineering working mostly under compressive loads. Failure of these components by buckling or excessive stress is an important design consideration. In the present study the effect of fiber orientation is studied on the failure load of a laminated curved panel subject to uniaxial

S. Adali; Izzet U. Cagdas




Microsoft Academic Search

Previous studies have indicated that the speed curve of the 100m dash consists of some distinct phases which can be used to analyze an athlete's performance. The purpose of this study was to introduce a method using a portable computer as a device for the measurement of sprint time and the illustration of the speed curve, and to clarify a

Kiichi Sugiyama; Yoshihisa Murata; Hiraku Watanabe; Takayuki Koike; Masanori Iwase


Modeling and regression analysis of semiochemical dose-response curves of insect antennal reception and behavior  

Technology Transfer Automated Retrieval System (TEKTRAN)

Dose-response curves with semiochemicals are reported in many articles in insect chemical ecology regarding neurophysiology and behavioral bioassays. Most such curves are shown in figures where the x-axis has order of magnitude increases in dosages versus responses on the y-axis represented by point...


Product Differentiation by Analysis of DNA Melting Curves during the Polymerase Chain Reaction  

Microsoft Academic Search

A microvolume fluorometer integrated with a thermal cycler was used to acquire DNA melting curves during polymerase chain reaction by fluorescence monitoring of the double-stranded DNA specific dye SYBR Green I. Plotting fluorescence as a function of temperature as the thermal cycler heats through the dissociation temperature of the product gives a DNA melting curve. The shape and position of

Kirk M. Ririe; Randy P. Rasmussen; Carl T. Wittwer



The theoretical analysis and algorithm on a class of optimal curve fitting problems  

Microsoft Academic Search

In this paper, the theory and algorithm on a class of optimal curve fitting problems which can be extensively applied to the engineering are established and completed. With regard to the curve fitting problems, the available theories and methods are largely concerned with the spline interpolation and linear or nonlinear least squares methods, and there are lots of ripe results.

Fusheng Wang; Kecun Zhang




SciTech Connect

We present a new approach to the analysis of time symmetry in light curves, such as those in the X-ray at the center of the Scorpius X-1 occultation debate. Our method uses a new parameterization for such events (the bilogistic event profile) and provides a clear, physically relevant characterization of each event's key features. We also demonstrate a Markov chain Monte Carlo algorithm to carry out this analysis, including a novel independence chain configuration for the estimation of each event's location in the light curve. These tools are applied to the Scorpius X-1 light curves presented in Chang et al., providing additional evidence based on the time series that the events detected thus far are most likely not occultations by trans-Neptunian objects.

Blocker, Alexander W. [Department of Statistics, Harvard University, 1 Oxford Street, Cambridge, MA 02138 (United States); Protopapas, Pavlos [Harvard-Smithsonian Center for Astrophysics, 60 Garden Street, Cambridge, MA 02138 (United States); Alcock, Charles R. [Initiative in Innovative Computing, Harvard University, 60 Oxford Street, Cambridge, MA 02138 (United States)



Ecological inference on bacterial succession using curve-based community fingerprint data analysis, demonstrated with rhizoremediation experiment.  


Nucleic acid-based community fingerprinting methods are valuable tools in microbial ecology, as they offer rapid and robust means to compare large series of replicates and references. To avoid the time-consuming and potentially subjective procedures of peak-based examination, we assessed the possibility to apply direct curve-based data analysis on community fingerprints produced with bacterial length heterogeneity PCR (LH-PCR). The dataset comprised 180 profiles from a 21-week rhizoremediation greenhouse experiment with three treatments and 10 sampling times. Curve-based analysis quantified the progressive effect of the plant (Galega orientalis) and the reversible effect of the contaminant (fuel oil) on bacterial succession. The major observed community shifts were assigned to changes in plant biomass and contamination level by canonical correlation analysis. A novel method to extract relative abundance data from the fingerprint curves for Shannon diversity index revealed contamination to reversibly decrease community complexity. By cloning and sequencing the fragment lengths, recognized to change in time in the averaged LH-PCR profiles, we identified Aquabacterium (Betaproteobacteria) as the putative r-strategic fuel oil degrader, and K-strategic Alphaproteobacteria growing in abundance later in succession. Curve-based community fingerprint analysis can be used for rapid data prescreening or as a robust alternative for the more heavily parameterized peak-based analysis. PMID:22066474

Mikkonen, Anu; Lappi, Kaisa; Wallenius, Kaisa; Lindström, Kristina; Suominen, Leena



Frequency curves  

USGS Publications Warehouse

This manual describes graphical and mathematical procedures for preparing frequency curves from samples of hydrologic data. It also discusses the theory of frequency curves, compares advantages of graphical and mathematical fitting, suggests methods of describing graphically defined frequency curves analytically, and emphasizes the correct interpretations of a frequency curve.

Riggs, H. C.



Growth curve analysis for plasma profiles using smoothing splines. Annual progress report, June 1992--June 1993  

SciTech Connect

We are developing a profile analysis code for the statistical estimation of the parametric dependencies of the temperature and density profiles in tokamaks. Our code uses advanced statistical techniques to determine the optimal fit, i.e. the fit which minimized the predictive error. For a forty TFTR Ohmic profile dataset, our preliminary results indicate that the profile shape depends almost exclusively on q{sub a}{prime} but that the shape dependencies are not Gaussian. We are now comparing various shape models on the TFTR data. In the first six months, we have completed the core modules of the code, including a B-spline package for variable knot locations, a data-based method to determine the optimal smoothing parameters, self-consistent estimation of the bias errors, and adaptive fitting near the plasma edge. Visualization graphics already include three dimensional surface plots, and discharge by discharge plots of the predicted curves with error bars together with the actual measurements values, and plots of the basis functions with errors.

Imre, K.



Analysis of stellar variability based on polynomial fittings of its light curve  

NASA Astrophysics Data System (ADS)

A method for analysis of stellar light curves (LCs), and in principle, time series, is presented here. It is based on polynomial fitting of the LC with increasing polynomial degree M. Two basic parameters from each polynomial fit of are regarded: residual mean square deviation (SD) of the data in respect to the polynomial fit, SM, and the half of the absolute average deviation of the polynomial (PD) in respect to the average of the data, PM. In each cases the maximal regarded polynomial degree L corresponds to the minimal SD, SL. (In practice the polynomial with degree L + 1 produces larger standard deviation because the number of data is not large and the calculation errors accumulate.) We found well pronounced anti-correlations between SM and PM when M changes from 1 to L. The respective slope PD/SD turns out to be a useful quantify parameter of the LC, characterizing the presence of significant coarse details and giving possibilities for classification of LCs.

Georgiev, Ts. B.



A study of the photo-degradation kinetics of nifedipine by multivariate curve resolution analysis.  


A multivariate curve resolution method based on the combination of Kubista approach and iterative target transformation method of Gemperline has been proposed. This method is a soft model and need no information about the spectrum of the product and mechanism of the reaction. The method was used to study the degradation kinetics of nifedipin, 1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridine dicarboxilic acid dimethyl ester, upon exposure to the light of a 40 W tungsten lamp. The spectra of the nifedipine, collected at different lighting times, were subjected to the factor analysis and two chemical components were detected in the reaction system. Pure spectra of the components involved and their concentration profiles were obtained. The results revealed that the photodecomposition kinetics of nifedipine is zero-order at the beginning of the reaction. However, when the reaction preceded more than 50%, the kinetics of reaction changed to a first-order manner. The rate constants for the zero-order and first order regions were estimated as regions (4.96+/-0.13) x 10(-9) M(-1) s(-1) and (6.22+/-0.10) x 10(-5) s(-1), respectively. PMID:12684114

Shamsipur, Mojtaba; Hemmateenejad, Bahram; Akhond, Morteza; Javidnia, Katayoun; Miri, Ramin



Lung cancer detection based on helical CT images using curved-surface morphology analysis  

NASA Astrophysics Data System (ADS)

Lung cancer is known as one of the most difficult cancers to cure. The detection of lung cancer in its early stage can be helpful for medical treatment to limit the danger. A conventional technique that assists the detection uses helical CT, which provides information of 3D cross sectional images of the lung. We expect that the proposed technique will increase diagnostic confidence. However, mass screening based on helical CT images leads to a considerable number of images for the diagnosis, this time-consuming fact makes it difficult to be used in the clinic. To increase the efficiency of the mass screening process, we had proposed a computer-aided diagnosis (CAD). In this paper, we describe lung cancer detection based on helical CT Images using curved surface morphology analysis. Firstly, we extract the lung area from the original image. Secondly, we compute shape index value of the lung area. Thirdly, we extract the ROI (Region Of Interest) from the computed shape index value. Finally, we apply the diagnosis rule using neural network and detect the suspicious regions. We show here the result of our algorithm which is applied to helical CT images of 390 patients.

Taguchi, Hiroshi; Kawata, Yoshiki; Niki, Noboru; Satoh, Hitoshi; Ohmatsu, Hironobu; Kakinuma, Ryutaro; Eguchi, Kenji; Kaneko, Masahiro; Moriyama, Noriyuki



Cognitive Vulnerabilities and Depression in Young Adults: An ROC Curves Analysis.  


Objectives and Methods. The aim of the present study was to evaluate, by means of receiver operating characteristic (ROC) curves, whether cognitive vulnerabilities (CV), as measured by three well-known instruments (the Beck Hopelessness Scale, BHS; the Life Orientation Test-Revised, LOT-R; and the Attitudes Toward Self-Revised, ATS-R), independently discriminate between subjects with different severities of depression. Participants were 467 young adults (336 females and 131 males), recruited from the general population. The subjects were also administered the Beck Depression Inventory-II (BDI-II). Results. Four first-order (BHS Optimism/Low Standard; BHS Pessimism; Generalized Self-Criticism; and LOT Optimism) and two higher-order factors (Pessimism/Negative Attitudes Toward Self, Optimism) were extracted using Principal Axis Factoring analysis. Although all first-order and second-order factors were able to discriminate individuals with different depression severities, the Pessimism factor had the best performance in discriminating individuals with moderate to severe depression from those with lower depression severity. Conclusion. In the screening of young adults at risk of depression, clinicians have to pay particular attention to the expression of pessimism about the future. PMID:24058734

Balsamo, Michela; Imperatori, Claudio; Sergi, Maria Rita; Belvederi Murri, Martino; Continisio, Massimo; Tamburello, Antonino; Innamorati, Marco; Saggino, Aristide



Cognitive Vulnerabilities and Depression in Young Adults: An ROC Curves Analysis  

PubMed Central

Objectives and Methods. The aim of the present study was to evaluate, by means of receiver operating characteristic (ROC) curves, whether cognitive vulnerabilities (CV), as measured by three well-known instruments (the Beck Hopelessness Scale, BHS; the Life Orientation Test-Revised, LOT-R; and the Attitudes Toward Self-Revised, ATS-R), independently discriminate between subjects with different severities of depression. Participants were 467 young adults (336 females and 131 males), recruited from the general population. The subjects were also administered the Beck Depression Inventory-II (BDI-II). Results. Four first-order (BHS Optimism/Low Standard; BHS Pessimism; Generalized Self-Criticism; and LOT Optimism) and two higher-order factors (Pessimism/Negative Attitudes Toward Self, Optimism) were extracted using Principal Axis Factoring analysis. Although all first-order and second-order factors were able to discriminate individuals with different depression severities, the Pessimism factor had the best performance in discriminating individuals with moderate to severe depression from those with lower depression severity. Conclusion. In the screening of young adults at risk of depression, clinicians have to pay particular attention to the expression of pessimism about the future.

Sergi, Maria Rita; Continisio, Massimo; Tamburello, Antonino; Innamorati, Marco; Saggino, Aristide



Couple's literacy level and acceptance of family planning methods: Lorenz curve analysis.  


The authors study the acceptance of family planning methods according to the level of couple's literacy in 14 states in India during 1986-87, using the Lorenz curve. The Gini Concentration Ratio and Index of Dissimilarity were calculated by level of couple's literacy for vasectomy, tubectomy, IUD, and all method combined. Firstly, analysis found literates to have accepted vasectomy and IUD more than tubectomy. Secondly, among the 3 methods, a high Gini Concentration Ratio was found for vasectomy when the wife was literate. Moreover, when the wife was literate, the Gini Concentration Ratio of IUD acceptance was higher than the acceptance of IUD by the wife whose husband was literate. Thirdly, the same trend was observed when the husband was illiterate. It is therefore clear that the level of a woman's literacy is a key factor in securing the acceptance of male or female methods of family planning. Planners should therefore concentrate on literacy programs for females independently of their age. Increasing the level of female literacy may ultimately help improve the understanding of family planning methods, while these women may also motivate their husbands to undergo vasectomy which will ultimately foster the success of the family planning program. PMID:12287029

Prakasam, C P; Murthy, P K



Numerical analysis of the stress-strain curve and fracture initiation for ductile material  

NASA Astrophysics Data System (ADS)

In the present paper, a way to obtain an accurate stress-strain curve of a ductile material under large plastic deformation (include necking) by tracing the experimental tensile loading-axial displacement curve using computer simulation is suggested. According to this method, the tested load (P)-deformation (Delta L) curve of the tensile specimen is considered as a target, and the true stress-strain curve of the material will be obtained when the simulated curve P(sup *) - Delta L(sup *) is completed using a large elastic-plastic deformation finite element program, by adjusting the trace of the stress-strain curve step by step according to the relative error of the simulated curve P(sup *) - Delta L(sup *) with the test one P-Delta L, under the condition that the relative error is controlled less than a given limit value. As a verification, in this paper, the method is applied to analyse the large deformation necking process of round smooth tensile specimen made of No. 45 steel. Furthermore, the Combinatorial Work Density Model (K. S. Zhang, C. Q. Zheng and N. S. Yang, Proc. ICM-6; K. S. Zhang and C. Q. Zheng, Engng Fracture Mech. 39, 851-857 (1991); Engng Fracture Mech. 39, 859-865 (1991)) is in troduced to judge the failure of a round notched tensile specimen made of the same material.

Zhang, K. S.; Li, Z. H.



Extensions to Regret-based Decision Curve Analysis: An application to hospice referral for terminal patients  

PubMed Central

Background Despite the well documented advantages of hospice care, most terminally ill patients do not reap the maximum benefit from hospice services, with the majority of them receiving hospice care either prematurely or delayed. Decision systems to improve the hospice referral process are sorely needed. Methods We present a novel theoretical framework that is based on well-established methodologies of prognostication and decision analysis to assist with the hospice referral process for terminally ill patients. We linked the SUPPORT statistical model, widely regarded as one of the most accurate models for prognostication of terminally ill patients, with the recently developed regret based decision curve analysis (regret DCA). We extend the regret DCA methodology to consider harms associated with the prognostication test as well as harms and effects of the management strategies. In order to enable patients and physicians in making these complex decisions in real-time, we developed an easily accessible web-based decision support system available at the point of care. Results The web-based decision support system facilitates the hospice referral process in three steps. First, the patient or surrogate is interviewed to elicit his/her personal preferences regarding the continuation of life-sustaining treatment vs. palliative care. Then, regret DCA is employed to identify the best strategy for the particular patient in terms of threshold probability at which he/she is indifferent between continuation of treatment and of hospice referral. Finally, if necessary, the probabilities of survival and death for the particular patient are computed based on the SUPPORT prognostication model and contrasted with the patient's threshold probability. The web-based design of the CDSS enables patients, physicians, and family members to participate in the decision process from anywhere internet access is available. Conclusions We present a theoretical framework to facilitate the hospice referral process. Further rigorous clinical evaluation including testing in a prospective randomized controlled trial is required and planned.



Clinical and molecular analysis in families with autosomal recessive osteogenesis imperfecta identifies mutations in five genes and suggests genotype-phenotype correlations.  


Autosomal recessive osteogenesis imperfecta (AR-OI) is an inherited condition which in recent years has been shown with increasing genetic and clinical heterogeneity. In this article, we performed clinical assessment and sought mutations in patients from 10 unrelated families with AR-OI, one of whom was presented with the additional features of Bruck syndrome (BS). Pathogenic changes were identified in five different genes: three families had mutations in FKBP10, three in SERPINF1, two in LEPRE1, one in CRTAP, and one in PPIB. With the exception of a FKBP10 mutation in the BS case, all changes are novel. Of note, insertion of an AluYb8 repetitive element was detected in exon 6 of SERPINF1. Since the studied patients had variable manifestations and some distinctive features, genotype/phenotype correlations are suggested. PMID:23613367

Caparrós-Martin, José A; Valencia, María; Pulido, Veronica; Martínez-Glez, Victor; Rueda-Arenas, Inmaculada; Amr, Khalda; Farra, Chantal; Lapunzina, Pablo; Ruiz-Perez, Victor L; Temtamy, Samia; Aglan, Mona



A Ritz vibration analysis of doubly-curved rectangular shallow shells using a refined first-order theory  

Microsoft Academic Search

Integral expressions for strain and kinetic energies in vibration analysis of shear deformable doubly-curved shallow shells are presented. Although the formulation follows the first-order shear deformation theory, the consideration of Lamé parameters for the transverse shear strain through shell thickness, which have been hitherto neglected by other researchers, shows linear distribution functions instead of constant values if the Lamé parameters

K. M. Liew; C. W. Lim



Detection and Genotyping of Oocysts of Cryptosporidium parvum by Real-Time PCR and Melting Curve Analysis  

Microsoft Academic Search

Several real-time PCR procedures for the detection and genotyping of oocysts of Cryptosporidium parvum were evaluated. A 40-cycle amplification of a 157-bp fragment from the C. parvum -tubulin gene detected individual oocysts which were introduced into the reaction mixture by micromanipulation. SYBR Green I melting curve analysis was used to confirm the specificity of the method when DNA extracted from

Sultan Tanrõverdi; Atila Tanyeli; Fikri Baslamõslõ; Fatih Koksal; Yurdanur Kõlõnc; Xiaochuan Feng; Glenda Batzer; Saul Tzipori; Giovanni Widmer



Rapid Detection of Aneuploidy (Trisomy 21) by Allele Quantification Combined with Melting Curves Analysis of Single-Nucleotide Polymorphism Loci  

Microsoft Academic Search

Background: Molecular approaches for the detection of chromosomal abnormalities will allow the development of rapid, cost-effective screening strategies. We present here a molecular alternative for the detection of aneu- ploidies and, more specifically, trisomy 21. Methods: We used the quantitative value of melting curve analysis of heterozygous genetic loci to establish a relative allelic count. The two alleles of a

Genevieve Pont-Kingdon; Elaine Lyon


The Obsessive Compulsive Scale of the Child Behavior Checklist predicts obsessive-compulsive disorder: a receiver operating characteristic curve analysis  

Microsoft Academic Search

Background: The purpose of this study was to determine a score on the Obsessive Compulsive Scale (OCS) from the Child Behavior Checklist (CBCL) to screen for obsessive compulsive disorder (OCD) in children and to rigorously test the specificity and sensitivity of a single cutpoint. Methods: A receiver operating characteristic (ROC) curve analysis was applied to data from 61 patients with

James J. Hudziak; Robert R. Althoff; Catherine Stanger; Beijsterveldt van C. E. M; Elliot C. Nelson; Gregory L. Hanna; Dorret I. Boomsma; Richard D. Todd



Fatigue of Curved Steel Bridge Elements - Analysis and Design of Plate Girder and Box Girder Test Assemblies.  

National Technical Information Service (NTIS)

This multi-phase investigation involves the performance of five tasks: (1) analysis and design of large scale plate girder and box girder test assemblies, (2) special studies of selected topics, (3) fatigue tests of the curved plate girder and box girder ...

D. Abraham J. H. Daniels N. Zettlemoyer R. P. Batcheler



Qualitative and quantitative analysis of the learning curve of a simulated surgical task on the da Vinci system  

Microsoft Academic Search

Background Robotic telemanipulation systems provide solutions to the problems of less dexterity and visual constraints of minimally invasive surgery (MIS). However, their influence over surgeons’ dexterity and learning curve needs to be assessed. We present motion analysis as an objective method to measure performance and learning progress. Methods Thirteen surgeons completed five synthetic small bowel anastomoses using the da Vinci

J. D. Hernandez; S. D. Bann; Y. Munz; K. Moorthy; V. Datta; S. Martin; A. Dosis; F. Bello; A. Darzi; T. Rockall



Selection Against Recessive Deleterious and Lethal Alleles  

Microsoft Academic Search

For a fully recessive allele with mutation rate to it ?, from it v and complete selection against homozygous recessives, the equilibrium frequency is approximately ?1\\/2. It is possible to reduce the equilibrium by eliminating from the breeding population all homozygous recessives and all individuals identified as heterozygous on the basis of having produced one or more homozygous progeny. The

J. F. Kidwell; G. W. Hagy



Analysis of Fractional Window Recoding Methods and Their Application to Elliptic Curve Cryptosystems  

Microsoft Academic Search

Elliptic curve cryptosystems (ECC) are suitable for memory-constraint devices like smart cards due to their small key-size. A standard way of computing elliptic curve scalar multiplication, the most frequent operation in ECC, is window methods, which enhance the efficiency of the binary method at the expense of some precomputation. The most established window methods are sliding window on NAF (NAF+SW),

Katja Schmidt-samoa; Olivier Semay; Tsuyoshi Takagi



Preliminary Analysis on Effect of Sleeper Pitch on Rail Corrugation at a Curved Track  

Microsoft Academic Search

This paper investigates the effect of sleeper pitch on the initiation and development of rail corrugation at a curved track\\u000a when a railway vehicle passes through the curved track using a numerical method. The numerical method considers a combination\\u000a of Kalker’s rolling contact theory with non-Hertzian form, a linear frictional work model and a dynamics model of a half railway

Xuesong Jin; Zefeng Wen; Qiyue Liu; Zhongrong Zhou


The Extended Learning Curve for Laparoscopic Fundoplication: A Cohort Analysis Of 400 Consecutive Cases  

Microsoft Academic Search

Many studies have looked at the learning curve associated with laparoscopic Nissen fundoplication (LNF) in a given institution.\\u000a This study looks at the learning curve of a single surgeon with a large cohort of patients over a 10-year period. Prospective\\u000a data were collected on 400 patients undergoing laparoscopic fundoplication for over 10 years. The patients were grouped consecutively\\u000a into cohorts of

J. Gill; M. I. Booth; J. Stratford; T. C. B. Dehn



Analysis of the arterial pressure-volume curve in the three-element windkessel model  

Microsoft Academic Search

A one-step computational procedure is presented for estimating the parameters of the nonlinear three-element windkessel model of the arterial system incorporating a pressure-dependent compliance. Starting from steady-state aortic pressure and flow curves and under generally accepted assumptions, arterial pressure-volume curve, peripheral and characteristic resistances are determined through simple closed-form formulas. The method is applied to both simulated and experimental data

A. Cappello; G. Gnudi



Functional groups in Quercus species derived from the analysis of pressure-volume curves  

Microsoft Academic Search

Oaks that occupy Mediterranean phytoclimates share common leaf features (evergreenness, high leaf dry mass per unit area, LMA). Due to this phytoclimatic, morphological, and phenological convergence it has been suggested that they might constitute a coherent functional group. To confirm this hypothesis, some physiological parameters were determined after calculating pressure-volume curves (P-V curves) using the free-transpiration method. Seventeen Quercus species

L. Corcuera; J. J. Camarero; E. Gil-Pelegrín



Performance analysis of CNC interpolators for time-dependent feedrates along PH curves  

Microsoft Academic Search

Virtually any desired time variation V(t) of the feedrate along a curved path can be realized by real-time CNC interpolator algorithms for the Pythagorean-hodograph (PH) curves: the only stipulation is that V(t) should admit a closed-form indefinite integral F(t). Different feedrate variations V(t) can be accommodated with minimal modifications to the core algorithm by employing a modular function call to

Yi-feng Tsai; Rida T. Farouki; Bryan Feldman



Recessions lower (some) mortality rates  

Microsoft Academic Search

In his article with the provocative title “Are Recessions Good for Your Health?”, Ruhm (J. Health Econ. 21(4) (2000) 659) has found robust and consistent evidence that the total mortality rate, age-specific mortality rates as well as most specific mortality causes are pro-cyclical. His finding that high unemployment rates are associated with lower mortality and vice versa stands in stark

Eric Neumayer



Evaluation of qPCR curve analysis methods for reliable biomarker discovery: bias, resolution, precision, and implications.  


RNA transcripts such as mRNA or microRNA are frequently used as biomarkers to determine disease state or response to therapy. Reverse transcription (RT) in combination with quantitative PCR (qPCR) has become the method of choice to quantify small amounts of such RNA molecules. In parallel with the democratization of RT-qPCR and its increasing use in biomedical research or biomarker discovery, we witnessed a growth in the number of gene expression data analysis methods. Most of these methods are based on the principle that the position of the amplification curve with respect to the cycle-axis is a measure for the initial target quantity: the later the curve, the lower the target quantity. However, most methods differ in the mathematical algorithms used to determine this position, as well as in the way the efficiency of the PCR reaction (the fold increase of product per cycle) is determined and applied in the calculations. Moreover, there is dispute about whether the PCR efficiency is constant or continuously decreasing. Together this has lead to the development of different methods to analyze amplification curves. In published comparisons of these methods, available algorithms were typically applied in a restricted or outdated way, which does not do them justice. Therefore, we aimed at development of a framework for robust and unbiased assessment of curve analysis performance whereby various publicly available curve analysis methods were thoroughly compared using a previously published large clinical data set (Vermeulen et al., 2009) [11]. The original developers of these methods applied their algorithms and are co-author on this study. We assessed the curve analysis methods' impact on transcriptional biomarker identification in terms of expression level, statistical significance, and patient-classification accuracy. The concentration series per gene, together with data sets from unpublished technical performance experiments, were analyzed in order to assess the algorithms' precision, bias, and resolution. While large differences exist between methods when considering the technical performance experiments, most methods perform relatively well on the biomarker data. The data and the analysis results per method are made available to serve as benchmark for further development and evaluation of qPCR curve analysis methods ( PMID:22975077

Ruijter, Jan M; Pfaffl, Michael W; Zhao, Sheng; Spiess, Andrej N; Boggy, Gregory; Blom, Jochen; Rutledge, Robert G; Sisti, Davide; Lievens, Antoon; De Preter, Katleen; Derveaux, Stefaan; Hellemans, Jan; Vandesompele, Jo



Fracture Recess: Asymmetric Continuum Approach  

NASA Astrophysics Data System (ADS)

This presentation is based on the Asymmetric Continuum Theory, which could be applied both for the solids, fluids and extreme motions: fractures, vortices, turbulence and shock waves. This theoretical approach is based on the papers concerning the solid and fluid continua (Teisseyre, 2009, publ. in "Bull. Seismol. Soc. Am." ; Teisseyre, 2010: publ. in "Acta Geophys."; Teisseyre, 2011, publ. in "Bull. Seismol. Soc. Am." and Teisseyre, 2012, publ. in "Acta Geophys."). These papers lead us also to the fracture processes situated in a kind of fracture recess, where the continuum might contain both solid and fluid elements. A similarity to the solid-fluid debris-flow models by Hutter and Schneider (2010, publ. in "Continuum Mech. Thermodyn.", parts 1,2) is underlined. In this approach the deformations and thus also strains are treated as the independent fields governed by the respective equations of motion. We derive such basic motion relations by an uniform approach; we extend our considerations to include also the extreme motions; a role of the release-rebound processes is underline. Our aim is to present a new attempt to describe the fracture processes which may appear inside a kind of fracture recess in a solid body; here such a recess is considered as a mixed continuum with both the solid and fluid phases.

Teisseyre, R.



Combined statistical analysis of vasodilation and flow curves in brachial ultrasonography: technique and its connection to cardiovascular risk factors  

NASA Astrophysics Data System (ADS)

Clinical studies report that impaired endothelial function is associated with Cardio-Vascular Diseases (CVD) and their risk factors. One commonly used mean for assessing endothelial function is Flow-Mediated Dilation (FMD). Classically, FMD is quantified using local indexes e.g. maximum peak dilation. Although such parameters have been successfully linked to CVD risk factors and other clinical variables, this description does not consider all the information contained in the complete vasodilation curve. Moreover, the relation between flow impulse and the vessel vasodilation response to this stimulus, although not clearly known, seems to be important and is not taken into account in the majority of studies. In this paper we propose a novel global parameterization for the vasodilation and the flow curves of a FMD test. This parameterization uses Principal Component Analysis (PCA) to describe independently and jointly the variability of flow and FMD curves. These curves are obtained using computerized techniques (based on edge detection and image registration, respectively) to analyze the ultrasound image sequences. The global description obtained through PCA yields a detailed characterization of the morphology of such curves allowing the extraction of intuitive quantitative information of the vasodilation process and its interplay with flow changes. This parameterization is consistent with traditional measurements and, in a database of 177 subjects, seems to correlate more strongly (and with more clinical parameters) than classical measures to CVD risk factors and clinical parameters such as LDL- and HDL-Cholesterol.

Boisrobert, Loic; Laclaustra, Martin; Bossa, Matias; Frangi, Andres G.; Frangi, Alejandro F.



An analysis of calibration curve models for solid-state heat-flow calorimeters  

SciTech Connect

Various calibration curve models for solid-state calorimeters are compared to determine which model best fits the calibration data. The calibration data are discussed. The criteria used to select the best model are explained. A conclusion regarding the best model for the calibration curve is presented. These results can also be used to evaluate the random and systematic error of a calorimetric measurement. A linear/quadratic model has been used for decades to fit the calibration curves for wheatstone bridge calorimeters. Excellent results have been obtained using this calibration curve model. The Multical software package uses this model for the calibration curve. The choice of this model is supported by 40 years [1] of calorimeter data. There is good empirical support for the linear/quadratic model. Calorimeter response is strongly linear. Calorimeter sensitivity is slightly lower at higher powers; the negative coefficient of the x{sup 2} term accounts for this. The solid-state calorimeter is operated using the Multical [2] software package. An investigation was undertaken to determine if the linear/quadratic model is the best model for the new sensor technology used in the solid-state calorimeter.

Hypes, P. A. (Philip A.); Bracken, D. S. (David S.); McCabe, G. (George)



Equations for the analysis of the light curves of extra-solar planetary transits  

NASA Astrophysics Data System (ADS)

Easy to use analytical formulae are presented for the computation the of light curves of extra-solar planetary transits. The equations are a function of the fractional radii of the planet and the parent star, the inclination of the orbit, and the limb-darkening coefficients of the star. Light curves can be solved for these parameters depending on the precision of the available observations. When the radial velocity curve is also available, as is normally the case to ensure the nature of the system, the masses, radii, and average density of both the star and the planet can be determined. The equations are valid for any degree of limb darkening, as well as for any type of transit. The cases of eccentric orbits, third light, or a non-zero relative luminosity of the planet can be easily taken into account. The basic assumption is that the projections of both the star and the planet on the plane of the sky are well represented by circular discs. The effects in case this assumption is not valid are also discussed. Practical applications are shown, beginning with the light curve of the photometrically discovered planet OGLE-TR-113, obtained with a ground-based telescope. As a second example, results are shown from the study of the light curve obtained for the transit of the giant planet in HD 209458 with the Hubble Space Telescope. Procedures to get the best fit parameters are briefly discussed.

Giménez, A.



Curved Mirrors  

NSDL National Science Digital Library

This inquiry activity will be used before discussing curved mirrors in class. Students will discover how curved mirrors act and how the size and the orientation of the image are related to the distance from the mirror. Ray diagrams for curved mirrors are

Horton, Michael



An Analysis of Peristaltic Flow of a Micropolar Fluid in a Curved Channel  

NASA Astrophysics Data System (ADS)

We analyze the two-dimensional peristaltic flow of a micropolar fluid in a curved channel. Long wavelength and low Reynolds number assumptions are used in deriving the governing equations. A shooting method with fourth-order Runge-Kutta algorithm is employed to solve the equations. The influence of dimensionless curvature radius on pumping and trapping phenomena is discussed with the help of graphical results. It is seen that the pressure rise per wavelength in the pumping region increases with an increase in the curvature of the channel. Moreover the symmetry of the trapped bolus destroys in going from straight to curved channel.

Ali, N.; Sajid, M.; Javed, T.; Abbas, Z.



Analysis of a Kepler Light Curve of the Novalike Cataclysmic Variable KIC 8751494  

NASA Astrophysics Data System (ADS)

We analyzed a Kepler light curve of KIC 8751494, a recently recognized novalike cataclysmic variable in the Kepler field. We detected a stable periodicity of 0.114379(1) d, which we identified as being the binary's orbital period. The stronger photometric period at around 0.12245 d, which had been detected from a ground-based observation, was found to be variable, and we identified this period as the positive-superhump period. This superhump period showed short-term (10-20 d) strong variations in period most unexpectedly when the object entered a slightly faint state. The fractional superhump excess varied by as much large as ˜ 30%. The variation of the period very well traced the variation of the brightness of the system. The time-scale of this variation of superhump periods was too slow to be interpreted as a variation caused by a change of the disk radius due to thermal disk instability. We interpreted the cause of the period variation as a varying pressure effect on the period of positive superhumps. This finding suggests that the pressure effect, in at least novalike systems, plays a very important (up to ˜ 30% in the precession rate) role in producing the period of positive superhumps. We also described a possible detection of negative superhumps with a varying period of 0.1071-0.1081 d in the Q14 run of the Kepler data, and found that the variation of frequency of negative superhumps followed that of positive superhumps. The relation between the fractional superhump excesses of negative and positive superhumps can be understood if the angular frequency of positive superhumps is decreased by a pressure effect. We also found that the phase of the variation in the velocity of the emission lines reported in the earlier study is compatible with the SW Sex-type classification. Further, we introduced a new two-dimentional period analysis using least absolute shrinkage and selection operator (Lasso), and showed superior advantages of this method.

Kato, Taichi; Maehara, Hiroyuki



Curved crystal x-ray optics for monochromatic analysis and imaging  

NASA Astrophysics Data System (ADS)

Monochromatic x-ray imaging has been shown to increase contrast and reduce dose relative to conventional broadband imaging. However, clinical sources with very narrow energy bandwidth tend to have limited intensity and field of view. In this study, focussed fan beam monochromatic radiation was obtained using doubly curved crystal (DCC) x-ray optics. The technique could be used with a variety of clinical sources for monochromatic slot scan imaging. The intensity was assessed and the resolution of the focussed beam was measured using a knife-edge technique. A simulation model was developed and comparisons to the measured resolution were performed to verify the accuracy of the simulation to predict resolution for different conventional sources. A simple geometrical calculation was also developed. The measured, simulated and calculated resolutions agreed well. Adequate resolution and intensity for mammography was predicted for appropriate source/optic combinations. Since DCC optics are employed in crystallography and x-ray fluorescence systems and may find application to imaging, it is increasingly important to understand how optic defects impact performance for these systems. The simulation model assessed the effects of misalignment and optic defects on system parameters such as intensity, beam size, and resolution. Simulation results were compared to optics measurements. Rapid reproducible measurements of optics quality are important both for performing systematic studies of optics defects and for assessing individual optics. A simple operator-independent alignment technique was developed that was also beneficial in ensuring optimal beam intensity in analysis systems. The measurements and simulations were in good agreement and provided insight into essential optics parameters. The optics were used in powder diffraction due to the advantages of the intense focused beams. Measurements were made using a low power microfocus source for several small inorganic samples. Diffracted peak width, resolution, and intensity were analyzed. The measured resolution was much smaller than the peak width due to the focussed beam, and was limited by the pixel size of the area detector. Resolution and intensity were in good agreement with those obtained from simple geometrical calculation. The simulation model was also used to understand the diffraction ring shape and width.

Bingolbali, Ahyan


Development of Oral Reading Fluency in Children with Speech or Language Impairments: A Growth Curve Analysis  

ERIC Educational Resources Information Center

|This longitudinal study used piece-wise growth curve analyses to examine growth patterns in oral reading fluency for 1,991 students with speech impairments (SI) or language impairments (LI) from first through third grade. The main finding of this study was that a diagnosis of SI or LI can have a detrimental and persistent effect on early reading…

Puranik, Cynthia S.; Petscher, Yaacov; Al Otaiba, Stephanie; Catts, Hugh W.; Lonigan, Christopher J.



Testing a developmental–ecological model of student engagement: a multilevel latent growth curve analysis  

Microsoft Academic Search

US schools fail to engage a significant proportion of adolescent students. Although student engagement is significantly related to academic achievement, there is a dearth of longitudinal research simultaneously examining the impact of personal and contextual factors on student engagement at both individual and school levels. Using a nationally?representative sample, multilevel growth curve analyses found significant factors related to adolescents’ student

Sukkyung You; Jill Sharkey



Nonlinear curve fitting for bioelectrical impedance data analysis: a minimum ellipsoid volume method  

Microsoft Academic Search

Bioelectrical impedance spectroscopy has become a widely used method with various applications in physiological and clinical investigations. Its measurement results are often analysed using the Cole-Cole model in an attempt to relate its parameters to structural or physiological characteristics of the studied object. The model parameter values are usually assessed by nonlinear curve fitting based on the least mean square

Stefan Dantchev; Feras Al-Hatib



Parametric analysis of liquid storage tanks base isolated by curved surface sliding bearings  

Microsoft Academic Search

Curved surface sliding bearings, which are usually called as friction pendulum system (FPS) are commonly used for base isolation of liquid storage tanks since the period of the isolation system is independent of the storage level. However the restoring force and the damping at the isolation system are functions of axial load which changes during an earthquake excitation. This change

Emre Abal?; Eren Uçkan



Acoustic emission analysis of full-scale honeycomb sandwich composite curved fuselage panels  

Microsoft Academic Search

Acoustic emission (AE) was monitored in notched full-scale honeycomb sandwich composite curved fuselage panels during loading. The purpose of the study was to evaluate the AE technique as a tool for detecting notch tip damage initiation and evaluating damage severity in such structures. This evaluation was a part of a more general study on the damage tolerance of six honeycomb

Frank A. Leone Jr.; Didem Ozevin; Valery Godinez; Bao Mosinyi; John G. Bakuckas Jr.; Jonathan Awerbuch; Alan Lau; Tein-Min Tan



Bayesian analysis of growth curves using mixed models defined by stochastic differential equations  

Microsoft Academic Search

Growth curve data consist of repeated measurements of a continuous growth process over time in a population of individuals. These data are classically analyzed by nonlinear mixed models. However, the standard growth functions used in this context prescribe monotone increasing growth and can fail to model unexpected changes in growth rates. We propose to model these variations using stochastic differential

Jean-Louis Foulley; Adeline Samson; Sophie Donnet



A Bayesian analysis of the effect of selection for growth rate on growth curves in rabbits  

Microsoft Academic Search

Gompertz growth curves were fitted to the data of 137 rabbits from control (C) and selected (S) lines. The animals came from a synthetic rabbit line selected for an increased growth rate. The embryos from generations 3 and 4 were frozen and thawed to be contemporary of rabbits born in generation 10. Group C was the offspring of generations 3

Agustín Blasco; Miriam Piles; Luis Varona



Analysis of thermoluminescence kinetics of CaF2(Tm) peaks with glow curve deconvolution  

Microsoft Academic Search

The purpose of this study is to achieve detailed information on kinetic parameters of the peaks of a dosimetric material. First and general order kinetic formulas are applied with a computerized deconvolution technique to CaF2(Tm) thermoluminescence glow curves. A comparison is presented between deconvolution kinetic parameters and parameters obtained applying Chen's method.

C. Bacci; P. Bernardini; A. di Domenico; C. Furetta; B. Rispoli



Analysis of Some Efficient Window Methods and their Application to Elliptic Curve Cryptosystems  

Microsoft Academic Search

Abstract: Elliptic curve cryptosystems (ECC) are suitable for smart cards due to their small key-size. We have to make an effort to reduce both computation time and memory usage on such memory-constraint devices. A standard way to achieve this goal are window methods, which can enhance the speed of the scalar multiplication with a reasonable memory usage. The most famous

Katja Schmidt-samoa; Olivier Semay; Tsuyoshi Takagi



A comparative analysis of learning curves: Implications for new technology implementation management  

Microsoft Academic Search

New technology implementation projects are notoriously over time and budget resulting in significant financial and strategic organizational consequences. Some argue that inadequate planning and management, misspecification of requirements, team capabilities and learning contribute to cost and schedule over runs. In this paper we examine how learning curve theory could inform better management of new technology implementation projects. Our research makes

Malgorzata Plaza; Ojelanki K. Ngwenyama; Katrin Rohlf



Curve fitting method for modeling and analysis of photovoltaic cells characteristics  

Microsoft Academic Search

This paper deals with the mathematical model to assess the performances of photovoltaic (PV) cells. The PV system characteristics are modeled and analyzed by using the curve fitting method referred to the different connections of PV cells and different solar irradiance. The results are compared with those resulting from measured data in a real case. Specific LabVIEW™ and Matlab™ software

H. Andrei; T. Ivanovici; G. Predusca; E. Diaconu; P. C. Andrei



The Dynamics of Self-Esteem: A Growth-Curve Analysis.  

ERIC Educational Resources Information Center

Using 7 years of sequential data from the Family Health Study for 762 subjects aged 11 to 16 years in year 1, estimated a hierarchical growth curve model that emphasized the effects of age, life events, gender, and family cohesion on self-esteem. Results show a curvilinear relationship between age and self-esteem, suggesting that self-esteem is a…

Baldwin, Scott A.; Hoffmann, John P.



Detecting and Attributing Change of Seasonal Base Flow Recession Slopes in Human Interfered Watersheds  

NASA Astrophysics Data System (ADS)

This study employs an empirical method that explicitly incorporates human interferences into base flow recession analysis to diagnose climatic and human factors responsible for long-term trends in winter and summer base flow in two watersheds in the American Midwest in which urban and irrigated agriculture land uses predominate. In the urban watershed, the recession slopes decrease over time during both winter (December, January, and February) and summer (June, July and August), i.e., the recession rate becomes slower (Table 1). On the other hand, in the agricultural watershed, the base flow recession slopes decrease over time in winter but increase in summer (Table 2). This study shows that all of the long-term base flow recession slope trends witnessed in both the urban and agricultural watersheds are mainly the result of human interferences. In the urban watershed, water diversions and effluent discharges cause the decreasing trend of recession slope in winter and summer. In the agricultural watershed, the seasonal water use regime of irrigated agriculture explains the opposite winter and summer trends. Sources of water withdrawal (groundwater versus surface water) also have different impact on the recession process. This long-term analysis of recession rates, as opposed to changes in low flow magnitude, offers additional insights on human interferences to hydrologic processes that may help us understand the complex coupled nature-human relationships that influence water availability from watersheds better.Table 1. Mean, coefficient of variation (CV) of recession slope and the number of recession events for the Salt Creek (urban) at Western Spring stream gage. Table 2. Mean, coefficient of variation (CV) of recession slope and the number of recession events for the Kankakee River (agricultural) at Momence stream gage.

Wang, D.; Cai, X.



The trauma of a recession.  


Employment in construction in Ireland fell by 10% from nearly 282,000 in the second quarter of 2007 to 255,000 in the same period of 2008. Our study looks at the differences in soft tissue upper limb trauma dynamics of a pre- and post-recession Ireland. Construction accounted for 330 patients (27%) of all hand injuries in 2006, but only 18 (3%) in 2009. Our data shows a significant drop in hand injuries related to the construction industry, and more home/DIY cases and deliberate self-harm presenting in their stead. PMID:21431394

Murphy, S M; Kieran, I; Shaughnessy, M O



Noise transmission from a curved panel into a cylindrical enclosure: analysis of structural acoustic coupling.  


Much of the research on sound transmission through the aircraft fuselage into the interior of aircraft has considered coupling of the entire cylinder to the acoustic modes of the enclosure. Yet, much of the work on structural acoustic control of sound radiation has focused on reducing sound radiation from individual panels into an acoustic space. Research by the authors seeks to bridge this gap by considering the transmission of sound from individual panels on the fuselage to the interior of the aircraft. As part of this research, an analytical model of a curved panel, with attached piezoelectric actuators, subjected to a static pressure load was previously developed. In the present work, the analytical model is extended to consider the coupling of a curved panel to the interior acoustics of a rigid-walled cylinder. Insight gained from an accurate analytical model of the dynamics of the noise transmission from the curved panels of the fuselage into the cylindrical enclosure of an aircraft is essential to the development of feedback control systems for the control of stochastic inputs, such as turbulent boundary layer excitation. The criteria for maximal structural acoustic coupling between the modes of the curved panel and the modes of the cylindrical enclosure are studied. For panels with aspect ratios typical of those found in aircraft, results indicate that predominately axial structural modes couple most efficiently to the acoustic modes of the enclosure. The effects of the position of the curved panel on the cylinder are also studied. Structural acoustic coupling is found to not be significantly affected by varying panel position. The impact of the findings of this study on structural acoustic control design is discussed. PMID:11325117

Henry, J K; Clark, R L



Learning curve analysis of robot-assisted radical hysterectomy for cervical cancer: initial experience at a single institution  

PubMed Central

Objective The aim of this study was to evaluate the learning curve and perioperative outcomes of robot-assisted laparoscopic procedure for cervical cancer. Methods A series of 65 cases of robot-assisted laparoscopic radical hysterectomies with bilateral pelvic lymph node dissection for early stage cervical cancer were included. Demographic data and various perioperative parameters including docking time, console time, and total operative time were reviewed from the prospectively collected database. Console time was set as a surrogate marker for surgical competency, in addition to surgical outcomes. The learning curve was evaluated using cumulative summation method. Results The mean operative time was 190 minutes (range, 117 to 350 minutes). Two unique phases of the learning curve were derived using cumulative summation analysis; phase 1 (the initial learning curve of 28 cases), and phase 2 (the improvement phase of subsequent cases in which more challenging cases were managed). Docking and console times were significantly decreased after the first 28 cases compared with the latter cases (5 minutes vs. 4 minutes for docking time, 160 minutes vs. 134 minutes for console time; p<0.001 and p<0.001, respectively). There was a significant reduction in blood loss during operation (225 mL vs. 100 mL, p<0.001) and early postoperative complication rates (28% vs. 8.1%, p=0.003) in phase 2. No conversion to laparotomy occurred. Conclusion Improvement of surgical performance in robot-assisted surgery for cervical cancer can be achieved after 28 cases. The two phases identified by cumulative summation analysis showed significant reduction in operative time, blood loss, and complication rates in the latter phase of learning curve.

Yim, Ga Won; Kim, Sang Wun; Nam, Eun Ji; Kim, Sunghoon



Multiplex Real-Time PCR Assay and Melting Curve Analysis for Identifying Mycobacterium tuberculosis Complex and Nontuberculous Mycobacteria  

PubMed Central

A multiplex real-time PCR assay and melting curve analysis for identifying 23 mycobacterial species was developed and evaluated using 77 reference strains and 369 clinical isolates. Concordant results were obtained for all 189 (100%) isolates of the Mycobacterium tuberculosis complex and 169 (93.9%) isolates of nontuberculous mycobacteria. Our results showed that this multiplex real-time PCR assay is an effective tool for the mycobacterial identification from cultures.

Cha, Choong-Hwan; An, Hae-Kyong




SciTech Connect

The present study concerns with the effects of material orthotropy,curvature, shear ratio and circumferential modulus under the influence of a temperature distribution throughout the shell structure. Here analysis is restricted to the study of nonlinear vibration of a doubly curved shell structure considering the periodic response of a simple bending mode due to curtailment of pages. Solutions of the problems with suitable illustrations are also presented.

Chanda, S.



Determination of sulphate in water and biodiesel samples by a sequential injection analysis—Multivariate curve resolution method  

Microsoft Academic Search

A spectrophotometric sequential injection analysis (SIA-DAD) method linked to multivariate curve resolution-alternating least squares (MCR-ALS) has been developed for sulphate determination. This method involves the reaction, inside the tubes of the SIA system, of sulphate with barium-dimethylsulphonazo (III) complex, Ba-DMSA (III), displacing Ba2+ from the complex and forming DMSA (III). When the reaction products reach the detector a data matrix

Vanessa del Río; M. Soledad Larrechi; M. Pilar Callao



The data mining III: An analysis of 21 eclipsing binary light-curves observed by the INTEGRAL/OMC  

NASA Astrophysics Data System (ADS)

Twenty-one eclipsing binaries were selected for an analysis from a huge database of observations made by the INTEGRAL/OMC camera. The photometric data were processed and analyzed, resulting in a first light-curve study of these neglected eclipsing binaries. In several systems from this sample even their orbital periods have been confirmed or modified. Thirty-two new minima times of these binaries have been derived.

Zasche, P.



EU labour market behaviour during the Great Recession  

Microsoft Academic Search

This paper provides an analysis of the labour market adjustment to the 2008-2009 recession. It highlights differences in the response of employment and unemployment across countries and different socioeconomic groups. For all EU Member States, it provides evidence of the developments during the crisis of the monthly job finding and separation rates. This helps to assess whether the increase in

Alfonso Arpaia; Nicola Curci



The gene mutated in autosomal recessive polycystic kidney disease encodes a large, receptor-like protein  

Microsoft Academic Search

Autosomal recessive polycystic kidney disease (ARPKD) is characterized by dilation of collecting ducts and by biliary dysgenesis and is an important cause of renal- and liver-related morbidity and mortality. Genetic analysis of a rat with recessive polycystic kidney disease revealed an orthologous relationship between the rat locus and the ARPKD region in humans; a candidate gene was identified. A mutation

Christopher J. Ward; Marie C. Hogan; Sandro Rossetti; Denise Walker; Tam Sneddon; Xiaofang Wang; Vicky Kubly; Julie M. Cunningham; Robert Bacallao; Masahiko Ishibashi; Dawn S. Milliner; Vicente E. Torres; Peter C. Harris



On the use of the Boussinesq equation for interpreting recession hydrographs from sloping aquifers  

Microsoft Academic Search

(1) The method of recession analysis proposed by Brutsaert and Nieber (1977) remains one of the few analytical tools for estimating aquifer hydraulic parameters at the field scale and beyond. In the method, the recession hydrograph is examined asdQ\\/dt = f(Q), where Q is aquifer discharge and f is an arbitrary function. The observed function f is parameterized through analytical

David E. Rupp; John S. Selker



On the use of the Boussinesq equation for interpreting recession hydrographs from sloping aquifers  

Microsoft Academic Search

The method of recession analysis proposed by Brutsaert and Nieber (1977) remains one of the few analytical tools for estimating aquifer hydraulic parameters at the field scale and beyond. In the method, the recession hydrograph is examined as ?dQ\\/dt = f(Q), where Q is aquifer discharge and f is an arbitrary function. The observed function f is parameterized through analytical

David E. Rupp; John S. Selker



Analysis of the optical light curve of the massive X-ray binary LMC X-4  

NASA Astrophysics Data System (ADS)

The long-term X-ray and optical brightness variations of LMC X-4 (period about 30 days) have been explained qualitatively as a result of a tilted counter-precessing accretion disk, as in the case of Her X-1 and SS 433. The optical light curve of LMC X-4 is analyzed using a geometric model which incorporates ellipsoidal variations, X-ray heating of the companion star. The effects of a precessing accretion disk (as a source of optical emission, partial X-ray shielding of the companion, and mutual eclipses) are also discussed. Although some discrepancies remain, the model provides a reasonable description of the 30-d variations of the orbital light curve of LMC X-4.

Heemskerk, M. H. M.; van Paradijs, J.



Genetic Analysis of a Selection Experiment on the Growth Curve of Chickens  

Microsoft Academic Search

A selection experiment on the shape of the growth curve was performed on meat-type chickens through combined selection on juvenile and adult BW. Line X?+ was selected for low BW at 8 wk (BW8) and high BW at 36 wk (BW36). Line X+? was selected for high BW8 and low BW36. Line X++ was selected for high BW8 and BW36,

S. Mignon-Grasteau; C. Beaumont; F. H. Ricard


Nonlinear analysis of steel–concrete composite beams curved in plan  

Microsoft Academic Search

This paper deals with the behavior of structural steel–concrete composite beams curved in plan. The finite element package ABAQUS has been used to study the nonlinear behavior and ultimate load-carrying capacity of such beams. A three-dimensional finite element model has been adopted. Shell elements have been used to simulate the behavior of concrete slab and steel girder, and rigid beam

V. Thevendran; S. Chen; N. E. Shanmugam; J. Y. Richard Liew



Micro-foundations of the Environmental Kuznets Curve hypothesis: an empirical analysis  

Microsoft Academic Search

The Environmental Kuznets Curve (EKC) hypothesis argues for an inverted-U shaped relationship between economic development and environmental quality. Although this relation has been mainly enquired at the macro-economic level, it is actually resting on the assumption of a number of changes in the attitudes and behaviours of high-income country citizens. This paper looks for empirical evidence underneath this assumption using

Giangiacomo Bravol; Beatrice Marelli



Reynolds-stress model analysis of turbulent flow over a curved axisymmetric body  

Microsoft Academic Search

A curvature-dependent Reynolds-stress model (CRSM) is proposed for prediction of complex turbulent flows over curved surfaces. A curvature time scale for the third-order diffusive transport terms in the Reynolds-stress equations is assumed, which is derived from analogy between buoyancy and streamline curvature effects on turbulence. The coefficient of the destruction term in the dissipation equation is also modified by the

Myung Kyoon Chung; Do Hyung Choi; Shin Bae Park



Analysis of Dose-Response Curves in the Detection of Bronchial Hyperreactivity  

Microsoft Academic Search

In 12 reference subjects and 23 asthmatic patients under clinical and functional remission, dose-response curves following inhalation of nebulized carbachol solution were performed. Response was assessed both in terms of SRaw and SGaw and the best fitting mathematical function (linear, exponential, polynomial and logarithmic) was looked for. Discriminating power and day-to-day reproducibility were better when using SGaw, independently from the

V. Bellia; A. Rizzo; S. Amoroso; A. Mirabella; G. Bonsignore



Analysis of the low part of stress-strain curves in rat skin  

Microsoft Academic Search

Stress-strain behaviour of skin strips in rats at different ages or after treatment with prednisolone or D-penicillamine has been analyzed. Special attention has been paid to the lower part of the stress-strain curves. A “hump” at an extension degree of 30% of original length was noted. When rats of different ages were compared this phenomenon was observed predominantly at an

H. G. Vogel; W. Hilgner



Breakthrough curve analysis of pressure swing adsorption for hydrogen isotope separation  

SciTech Connect

For the purpose of developing an effective system for hydrogen isotope separation, we have been studying the adsorption-desorption dynamic behavior of hydrogen and deuterium in a packed-bed column with synthetic zeolites, aimed at applying the pressure swing adsorption process. The adsorption behavior of molecules in the packed-bed is reflected in the breakthrough curves. To understand the characteristic behaviors of hydrogen isotopes in the packed-bed, we carried out breakthrough experiments in a conventional adsorption process and in a practical process following sequential processes alternating between adsorption and desorption. From the former experiments, the results were obtained that the overall mass transfer was influenced by longitudinal dispersion relating to the superficial velocity and that the process governing the mass transfer within adsorbents was diffusion in the macro-pores of pellets. In the latter experiments, unique profile breakthrough curves were observed. These curves can be described with the numerical simulation assuming the initial distributions in a packed-bed. (authors)

Kotoh, K. [Faculty of Eng., Kyushu Univ., 744 Moto-oka, Nishi-ku, Fukuoka 819-0395 (Japan); Tanaka, M. [National Inst. for Fusion Science, 322-6 Oroshi-cho, Toki-shi, Gifu 509-5292 (Japan); Sakamoto, T.; Nakamura, Y. [Faculty of Eng., Kyushu Univ., 744 Moto-oka, Nishi-ku, Fukuoka 819-0395 (Japan); Asakura, Y.; Uda, T. [National Inst. for Fusion Science, 322-6 Oroshi-cho, Toki-shi, Gifu 509-5292 (Japan); Sugiyama, T. [Faculty of Eng., Nagoya Univ., Furo-cho, Chikusa-ku, Nagoya 464-8603 (Japan)



Analysis of variation in calibration curves for Kodak XV radiographic film using model-based parameters.  


Film calibration is time-consuming work when dose accuracy is essential while working in a range of photon scatter environments. This study uses the single-target single-hit model of film response to fit the calibration curves as a function of calibration method, processor condition, field size and depth. Kodak XV film was irradiated perpendicular to the beam axis in a solid water phantom. Standard calibration films (one dose point per film) were irradiated at 90 cm source-to-surface distance (SSD) for various doses (16-128 cGy), depths (0.2, 0.5, 1.5, 5, 10 cm) and field sizes (5 × 5, 10 × 10 and 20 × 20 cm²). The 8-field calibration method (eight dose points per film) was used as a reference for each experiment, taken at 95 cm SSD and 5 cm depth. The delivered doses were measured using an Attix parallel plate chamber for improved accuracy of dose estimation in the buildup region. Three fitting methods with one to three dose points per calibration curve were investigated for the field sizes of 5 × 5, 10 × 10 and 20 × 20 cm². The inter-day variation of model parameters (background, saturation and slope) were 1.8%, 5.7%, and 7.7% (1 ?) using the 8-field method. The saturation parameter ratio of standard to 8-field curves was 1.083 ± 0.005. The slope parameter ratio of standard to 8-field curves ranged from 0.99 to 1.05, depending on field size and depth. The slope parameter ratio decreases with increasing depth below 0.5 cm for the three field sizes. It increases with increasing depths above 0.5 cm. A calibration curve with one to three dose points fitted with the model is possible with 2% accuracy in film dosimetry for various irradiation conditions. The proposed fitting methods may reduce workload while providing energy dependence correction in radiographic film dosimetry. This study is limited to radiographic XV film with a Lumisys scanner. PMID:21081874

Hsu, Shu-Hui; Kulasekere, Ravi; Roberson, Peter L




SciTech Connect

We combine new observations from the Hubble Space Telescope's Advanced Camera of Survey with existing data to investigate the wavelength dependence of near-IR (NIR) extinction. Previous studies suggest a power law form for NIR extinction, with a 'universal' value of the exponent, although some recent observations indicate that significant sight line-to-sight line variability may exist. We show that a power-law model for the NIR extinction provides an excellent fit to most extinction curves, but that the value of the power, {beta}, varies significantly from sight line to sight line. Therefore, it seems that a 'universal NIR extinction law' is not possible. Instead, we find that as {beta} decreases, R(V) {identical_to} A(V)/E(B - V) tends to increase, suggesting that NIR extinction curves which have been considered 'peculiar' may, in fact, be typical for different R(V) values. We show that the power-law parameters can depend on the wavelength interval used to derive them, with the {beta} increasing as longer wavelengths are included. This result implies that extrapolating power-law fits to determine R(V) is unreliable. To avoid this problem, we adopt a different functional form for NIR extinction. This new form mimics a power law whose exponent increases with wavelength, has only two free parameters, can fit all of our curves over a longer wavelength baseline and to higher precision, and produces R(V) values which are consistent with independent estimates and commonly used methods for estimating R(V). Furthermore, unlike the power-law model, it gives R(V)s that are independent of the wavelength interval used to derive them. It also suggests that the relation R(V) = -1.36 E(K-V)/(E(B-V)) - 0.79 can estimate R(V) to {+-}0.12. Finally, we use model extinction curves to show that our extinction curves are in accord with theoretical expectations, and demonstrate how large samples of observational quantities can provide useful constraints on the grain properties.

Fitzpatrick, E. L. [Department of Astronomy and Astrophysics, Villanova University, 800 Lancaster Avenue, Villanova, PA 19085 (United States); Massa, D. [SGT, Inc., Space Telescope Science Institute, 3700 San Martin Dr., Baltimore, MD 21218 (United States)], E-mail:, E-mail:



Unlocking the potential of survival data for model organisms through a new database and online analysis platform: SurvCurv.  


Lifespan measurements, also called survival records, are a key phenotype in research on aging. If external hazards are excluded, aging alone determines the mortality in a population of model organisms. Understanding the biology of aging is highly desirable because of the benefits for the wide range of aging-related diseases. However, it is also extremely challenging because of the underlying complexity. Here, we describe SurvCurv, a new database and online resource focused on model organisms collating survival data for storage and analysis. All data in SurvCurv are manually curated and annotated. The database, available at, offers various functions including plotting, Cox proportional hazards analysis, mathematical mortality models and statistical tests. It facilitates reanalysis and allows users to analyse their own data and compare it with the largest repository of model-organism data from published experiments, thus unlocking the potential of survival data and demographics in model organisms. PMID:23826631

Ziehm, Matthias; Thornton, Janet M



Recession-based hydrological models for estimating low flows in ungauged catchments in the Himalayas  

NASA Astrophysics Data System (ADS)

The Himalayan region of Nepal and northern India experiences hydrological extremes from monsoonal floods during July to September, when most of the annual precipitation falls, to periods of very low flows during the dry season (December to February). While the monsoon floods cause acute disasters such as loss of human life and property, mudslides and infrastructure damage, the lack of water during the dry season has a chronic impact on the lives of local people. The management of water resources in the region is hampered by relatively sparse hydrometerological networks and consequently, many resource assessments are required in catchments where no measurements exist. A hydrological model for estimating dry season flows in ungauged catchments, based on recession curve behaviour, has been developed to address this problem. Observed flows were fitted to a second order storage model to enable average annual recession behaviour to be examined. Regionalised models were developed, using a calibration set of 26 catchments, to predict three recession curve parameters: the storage constant; the initial recession flow and the start date of the recession. Relationships were identified between: the storage constant and catchment area; the initial recession flow and elevation (acting as a surrogate for rainfall); and the start date of the recession and geographic location. An independent set of 13 catchments was used to evaluate the robustness of the models. The regional models predicted the average volume of water in an annual recession period (1st of October to the 1st of February) with an average error of 8%, while mid-January flows were predicted to within ±50% for 79% of the catchments in the data set.

Rees, H. G.; Holmes, M. G. R.; Young, A. R.; Kansakar, S. R.


Classification Using Growth Curves  

Microsoft Academic Search

Classification using the growth curve model is analyzed according to whether the covariance matrix structure is known to be compound symmetric. A new classification procedure appropriate for classification in the case of models with means that follow a Potthoff and Roy [Potthoff, R. F., Roy, S. N. (1964). A generalized multivariate analysis of variance model useful especially for growth curve

Graciela B. Mentz; Anant M. Kshirsagar



Criticism of Lake's analysis of the rotation curves of dwarf spirals  

NASA Astrophysics Data System (ADS)

This paper disputes the presence of a disparity found by Lake (1989) between the predictions of MOND and the observed rotation curves of five (out of the total six observed) dwarf spirals. Lake reported that the observed rotation velocities of DDO 154, NGC 3109, VCC 381, IC 1613, and DDO 125 were smaller than the velocities predicted by MOND by factors of about 1.2, 1.3, 1.5, 2, and 1.8. It is shown that, in each case, errors in the adopted distances and/or inclinations can fully account for the observed disparities between the theory and measurements.

Milgrom, Mordehai



Application of the Van Slyke-Cullen irreversible mechanism in the analysis of enzymatic progress curves.  


For enzymatic progress curves conforming to the Michaelis-Menten mechanism E+Sright harpoon over left harpoonES-->E+P, the minimal fitting model cast as a system of numerically integrated differential equations is the simplified, irreversible Van Slyke-Cullen mechanism E+S-->ES-->E+P. The best-fit value of the bimolecular association rate constant is identical to the specificity constant kcat/KM. An illustrative example involves a fluorogenic continuous assay of the HIV protease, analyzed by the differential-equation oriented software package DYNAFIT [P. Kuzmic, Anal. Biochem. 237 (1996) 260]. PMID:19627979

Kuzmic, Petr



Statistical survey of "saturation analysis" calibration curve data for prednisolone, prednisone and digoxin.  


An extensive survey of radioimmunoassay calibration data for prednisolone, prednisone and digoxin indicated that the common practice of preparing calibration curves with individual subject's pre-dose plasma or serum, and using this to estimate unknown concentrations for the same subject, is not supported by statistical considerations. Preparation of calibration plots from pooled data is better because this introduces less bias in estimated concentrations. Such a method also saves a great deal of time, since it is not necessary to repeat the calibration procedure each time, "unknowns" are being assayed. The data suggest that there is no optimum calibration plot for all radioimmunoassays. Rather, each antibody-drug combination should be investigated thoroughly to determine the best calibration plot for the particular combination. We found that the best calibration plots are: the logistic-logarithmic plot for prednisolone; nonlinear least squares fit to a polyexponential equation for nisolone; nonlinear least squares fit to a polyexponential equation for prednisone; and a weighted least squares regression of normalized % bound versus concentration for figoxin. The error in the radioimmunoassay is usually concentration-dependent, and, in certain regions of the standard curve, is larger than the literature indicates, since, frequently, the error has been gauged from % bound values, but should be guaged from inversely-estimated concentrations. PMID:982496

Tembo, A V; Schork, M A; Wagner, J G



Measuring recession severity and its impact on healthcare expenditure.  


The financial crisis that manifested itself in late 2007 resulted in a Europe-wide economic crisis by 2009. As the economic climate worsened, Governments and households were put under increased strain and more focus was placed on prioritising expenditures. Across European countries and their heterogeneous health care systems, this paper examines the initial responsiveness of health expenditures to the crisis and whether recession severity can be considered a predictor of health expenditure growth. In measuring severity we move away from solely gross domestic product (GDP) as a metric and construct a recession severity index predicated on a number of key macroeconomic indicators. We then regress this index on measures of total, public and private health expenditure to identify potential relationships. Analysis suggests that for 2009, the Baltic States, along with Ireland, Italy and Greece, experienced comparatively severe recessions. We find, overall, an initial counter-cyclical response in health spending (both public and private) across countries. However, our analysis finds evidence of a negative relationship between recession severity and changes in certain health expenditures. As a predictor of health expenditure growth in 2009, the derived index is an improvement over GDP change alone. PMID:23417124

Keegan, Conor; Thomas, Steve; Normand, Charles; Portela, Conceição



Market Freedom and the Global Recession  

Microsoft Academic Search

This study finds that the set of policies that favor liberalization in credit markets (regulatory quality) are negatively correlated with countries’ resilience to the recent recession as measured by output growth in 2008 and 2009. The Global nature of the recession and the cross-country heterogeneity of its depth provide a unique opportunity to examine the link between the structural characteristics

Domenico Giannone; Michele Lenza; Lucrezia Reichlin



The Crucial Role of Recess in Schools  

ERIC Educational Resources Information Center

|Background: Recess is at the heart of a vigorous debate over the role of schools in promoting optimal child development and well-being. Reallocating time to accentuate academic concerns is a growing trend and has put recess at risk. Conversely, pressure to increase activity in school has come from efforts to combat childhood obesity. The purpose…

Ramstetter, Catherine L.; Murray, Robert; Garner, Andrew S.




Microsoft Academic Search

Deficiencies of coagulation factors that cause a bleeding disorder, other than factor VIII and factor IX, are inherited as autosomal recessive traits and are generally rare, with prevalence in the general population varying between 1 in 500 000 and 1 in 2 000 000. In the last few years, the number of patients with recessively transmitted coagulation deficiencies has increased

F. Peyvandi; R. Asselta; P. M. Mannucci



Is Crowd Out A Problem In Recessions?  

Microsoft Academic Search

The crowd out effects of the government deficit is tested by adding it to consumption and investment models which control extensively for other factors. Effects are calculated for recession and non-recession periods, and compared to models with average crowd out, and models without crowd out. Test results indicate 1) deficits crowd out private consumption and investment, are statistically significant, and

John J. Heim



Is the financial crisis causing a recession?  

Microsoft Academic Search

The U.S. entered a recession in December 2007. Coming in train with a foreclosure crisis that began in late 2006 and its associated financial crisis that began in August 2007, there is a tendency for analysts to attribute the recession to the financial crisis. The worst aspects of the financial crisis that attract attention today did not begin until September

John Tatom



Light Curve Analysis for W UMa-Type Eclipsing Binary Star Systems  

NASA Astrophysics Data System (ADS)

We report results from summer 2006 in an ongoing study of eclipsing binary stars. Our investigations have focused on the measurement and interpretation of light curves for W UMa-type systems 44i Boötis and VW Cephei. These contact binaries have component stars of spectral type G, and revolve with periods of 6.43 and 6.67 hours. Dome automation and scripting capabilities introduced this summer have significantly reduced experimental uncertainties in our data. In support of previous findings we continue to observe an increase in the orbital period of 44i Boo at a rate of 10.4 µs/epoch or 14.2 ms/yr. Residuals computed after incorporating the increasing period suggest an underlying sinusoidal oscillation with a 61.5 year period and amplitude of 648 seconds. AAPT Member Thomas Olsen is sponsoring the lead presenter, SPS Member Scott Henderson, and the co-presenter, SPS Member Nick Peach.

Henderson, Scott; Peach, N.; Olsen, T.



A Linear Programing Economic Analysis of Lake Quality Improvements Using Phosphorus Buffer Curves  

NASA Astrophysics Data System (ADS)

A linear programing model is used to evaluate the economic feasibility of reducing phosphorus loads from cropland to levels that are expected to alter adequately the trophic conditions of a water supply reservoir. The model employs phosphorus buffer curves for distributing phosphorus losses between runoff and eroded soil. Phosphorus pollution reductions are estimated for conservation activities according to the amount of erosion control and phosphorus fertility status. The planning model is intended to provide the best available estimates of pollution control attainable with given budget outlays, as well as to allocate pollution control funds efficiently among watersheds. It also contains sufficient detail to suggest practices for each local soil that are consistent with water quality plans.

Ogg, Clayton W.; Pionke, Harry B.; Heimlich, Ralph E.



Quantitative Vibrational Imaging by Hyperspectral Stimulated Raman Scattering Microscopy and Multivariate Curve Resolution Analysis  

PubMed Central

Spectroscopic imaging has been an increasingly critical approach for unveiling specific molecules in biological environments. Towards this goal, we demonstrate hyperspectral stimulated Raman loss (SRL) imaging by intra-pulse spectral scanning through a femtosecond pulse shaper. The hyperspectral stack of SRL images is further analyzed by a multivariate curve resolution (MCR) method to reconstruct quantitative concentration images for each individual component and retrieve the corresponding vibrational Raman spectra. Using these methods, we demonstrate quantitative mapping of dimethyl sulfoxide concentration in aqueous solutions and in fat tissue. Moreover, MCR is performed on SRL images of breast cancer cells to generate maps of principal chemical components along with their respective vibrational spectra. These results show the great capability and potential of hyperspectral SRL microscopy for quantitative imaging of complicated biomolecule mixtures through resolving overlapped Raman bands.

Zhang, Delong; Wang, Ping; Slipchenko, Mikhail N.; Ben-Amotz, Dor; Weiner, Andrew M.; Cheng, Ji-Xin



Simultaneous detection of Listeria monocytogenes and Salmonella spp. in dairy products using real time PCR-melt curve analysis  

Microsoft Academic Search

The present investigation reports development of post real time PCR (RTi-PCR) - melt curve analysis for simultaneous detection\\u000a of Listeria monocytogenes and Salmonella spp. The optimal Sybr Green I (SG-I) concentration of 1.6 ?M resulted in two specific peaks with melting temperature (Tm)\\u000a of 79.90?±?0.39 °C and 86.29?±?0.13 °C for L. monocytogenes and Salmonella spp respectively. The detection sensitivity of the assay in

Jitender Singh; Virender K. Batish; Sunita Grover


Simultaneous detection of Fusarium culmorum and F. graminearum in plant material by duplex PCR with melting curve analysis  

PubMed Central

Background Fusarium head blight (FHB) is a disease of cereal crops, which has a severe impact on wheat and barley production worldwide. Apart from reducing the yield and impairing grain quality, FHB leads to contamination of grain with toxic secondary metabolites (mycotoxins), which pose a health risk to humans and livestock. The Fusarium species primarily involved in FHB are F. graminearum and F. culmorum. A key prerequisite for a reduction in the incidence of FHB is an understanding of its epidemiology. Results We describe a duplex-PCR-based method for the simultaneous detection of F. culmorum and F. graminearum in plant material. Species-specific PCR products are identified by melting curve analysis performed in a real-time thermocycler in the presence of the fluorescent dye SYBR Green I. In contrast to multiplex real-time PCR assays, the method does not use doubly labeled hybridization probes. Conclusion PCR with product differentiation by melting curve analysis offers a cost-effective means of qualitative analysis for the presence of F. culmorum and F. graminearum in plant material. This method is particularly suitable for epidemiological studies involving a large number of samples.

Brandfass, Christoph; Karlovsky, Petr



Curved Girder Computer Manual.  

National Technical Information Service (NTIS)

This report presents three computer programs based on analytical techniques of the slope deflection Fourier Series previously developed under this HP and R study. The COBRA (Curved Orthotropic Bridge Analysis) slope deflection computer programs can be use...

L. C. Bell C. P. Heins



Determination of Stress-Strain Curve for Microelectronic Solder Joint by ESPI Measurement and FE Analysis  

Microsoft Academic Search

Many thermomechanical reliability studies on microelectronics and microsystems have relied upon computational analysis, since experimental work is rather difficult and very time-consuming. For computational analysis, it is essential to use as input accurate material properties; if not, the results of a reliability analysis may be very inaccurate. However, it is still quite difficult to arrive at unified material properties for

Baik Woo Lee; Jeung Hyun Jeong; Woosoon Jang; Ju Young Kim; Dong Won Kim; Dongil Kwon; Jae Woong Nah; Kyung Wook Paik




Microsoft Academic Search

Estimation of extreme flood for different return period is required in design of various hydraulic structures. Regional flood frequency analysis is an effective method for estimating such extreme flood. Delineation of hydrologic homogeneous regions is key step in success of regional flood frequency analysis. This study deals hydrologic regionalization of Nepalese territory. Cluster analysis, a multivariate technique, is generally used

Binaya Kumar Mishra; Kaoru Takara; Yasuto Tachikawa


Robust strategies for automated AFM force curve analysis-II: adhesion-influenced indentation of soft, elastic materials.  


In the first of this two-part discourse on the extraction of elastic properties from atomic force microscopy (AFM) data, a scheme for automating the analysis of force-distance curves was introduced and experimentally validated for the Hertzian (i.e., linearly elastic and noninteractive probe-sample pairs) indentation of soft, inhomogeneous materials. In the presence of probe-sample adhesive interactions, which are common especially during retraction of the rigid tip from soft materials, the Hertzian models are no longer adequate. A number of theories (e.g., Johnson-Kendall-Roberts and Derjaguin-Muller-Toporov), covering the full range of sample compliance relative to adhesive force and tip radius, are available for analysis of such data. We incorporated Pietrement and Troyon's approximation (2000, "General Equations Describing Elastic Indentation Depth and Normal Contact Stiffness Versus Load," J. Colloid Interface Sci., 226(1), pp. 166-171) of the Maugis-Dugdale model into the automated procedure. The scheme developed for the processing of Hertzian data was extended to allow for adhesive contact by applying the Pietrement-Troyon equation. Retraction force-displacement data from the indentation of polyvinyl alcohol gels were processed using the customized software. Many of the retraction curves exhibited strong adhesive interactions that were absent in extension. We compared the values of Young's modulus extracted from the retraction data to the values obtained from the extension data and from macroscopic uniaxial compression tests. Application of adhesive contact models and the automated scheme to the retraction curves yielded average values of Young's modulus close to those obtained with Hertzian models for the extension curves. The Pietrement-Troyon equation provided a good fit to the data as indicated by small values of the mean-square error. The Maugis-Dugdale theory is capable of accurately modeling adhesive contact between a rigid spherical indenter and a soft, elastic sample. Pietrement and Troyon's empirical equation greatly simplifies the theory and renders it compatible with the general automation strategies that we developed for Hertzian analysis. Our comprehensive algorithm for automated extraction of Young's moduli from AFM indentation data has been expanded to recognize the presence of either adhesive or Hertzian behavior and apply the appropriate contact model. PMID:18067395

Lin, David C; Dimitriadis, Emilios K; Horkay, Ferenc



3 Tesla Dynamic Contrast Enhanced Magnetic Resonance Imaging of the Breast: Pharmacokinetic Parameters versus Conventional Kinetic Curve Analysis  

PubMed Central

Purpose To evaluate the incremental value of pharmacokinetic analysis of dynamic contrast enhanced (DCE) magnetic resonance imaging (MRI) compared to conventional breast MRI (morphology plus kinetic curve type analysis) in characterizing breast lesions as malignant or benign. Patients and Methods The study was approved by our institutional review board. Patients underwent 3D high resolution T1 (3DT1) contrast enhanced MRI and dynamic contrast enhancement (DCE) MRI at 3T, and had pathology proven diagnosis (95%) or more than 2 years follow up confirming lesion stability (5%). Lesions were identified using the high-spatial resolution post-contrast MRI. Morphologic features (margin, enhancement pattern) and conventional DCE-MRI results (kinetic curve types I, II or III) or pharmacokinetic parameters (wash-in rate Ktrans, washout rate Kep, and leakage space volume Ve), were included in multivariate models for prediction of benign versus malignant diagnosis. Results 95 patients with 101 lesions were included: 52% of patients were pre-menopausal and 48% post-menopausal. Sixty eight lesions (67.3%) were malignant and 33 (32.7%) were benign. There was a significant association between Ktrans and Kep and the diagnosis of benign versus malignant (p<0.001). The AUC for morphologic features (lesion margin and enhancement pattern) was 0.85, while inclusion of Ktrans or Kep in the model showed similar modest improvement in performance (AUC, 0.88–0.89). Conclusion The use of kinetic curve type assessment or pharmacokinetic modeling in conjunction with high resolution 3D breast MRI appears to offer similar improvement in diagnostic performance..

El Khouli, Riham H.; Macura, Katarzyna J.; Kamel, Ihab R.; Jacobs, Michael A.; Bluemke, David A.




SciTech Connect

We present nine newly observed transits of TrES-3, taken as part of a transit timing program using the RISE instrument on the Liverpool Telescope. A Markov-Chain Monte Carlo analysis was used to determine the planet-star radius ratio and inclination of the system, which were found to be R{sub p} /R {sub *} = 0.1664{sup +0.0011} {sub -0.0018} and i = 81.73{sup +0.13} {sub -0.04}, respectively, consistent with previous results. The central transit times and uncertainties were also calculated, using a residual-permutation algorithm as an independent check on the errors. A re-analysis of eight previously published TrES-3 light curves was conducted to determine the transit times and uncertainties using consistent techniques. Whilst the transit times were not found to be in agreement with a linear ephemeris, giving {chi}{sup 2} = 35.07 for 15 degrees of freedom, we interpret this to be the result of systematics in the light curves rather than a real transit timing variation. This is because the light curves that show the largest deviation from a constant period either have relatively little out-of-transit coverage or have clear systematics. A new ephemeris was calculated using the transit times and was found to be T{sub c} (0) = 2454632.62610 {+-} 0.00006 HJD and P = 1.3061864 {+-} 0.0000005 days. The transit times were then used to place upper mass limits as a function of the period ratio of a potential perturbing planet, showing that our data are sufficiently sensitive to have probed sub-Earth mass planets in both interior and exterior 2:1 resonances, assuming that the additional planet is in an initially circular orbit.

Gibson, N. P.; Pollacco, D.; Simpson, E. K.; Barros, S.; Joshi, Y. C.; Todd, I.; Keenan, F. P. [Astrophysics Research Centre, School of Mathematics and Physics, Queen's University, University Road, Belfast, BT7 1NN (United Kingdom); Skillen, I.; Benn, C. [Isaac Newton Group of Telescopes, Apartado de Correos 321, E-38700 Santa Cruz de la Palma, Tenerife (Spain); Christian, D. [Physics and Astronomy Department, California State University Northridge, Northridge, California 91330-8268 (United States); Hrudkova, M. [Astronomical Institute, Charles University Prague, V Holesovickach 2, CZ-180 00 Praha (Czech Republic); Steele, I. A. [Astrophysics Research Institute, Liverpool John Moores University, CH61 4UA (United Kingdom)], E-mail:



Identification of the dinoflagellate community during Cochlodinium polykrikoides (Dinophyceae) blooms using amplified rDNA melting curve analysis and real-time PCR probes  

Microsoft Academic Search

The dinoflagellate community present during blooms of the fish killing dinoflagellate Cochlodinium polykrikoides was characterized by DNA melting curve analysis and direct sequencing of the SSU rDNA amplified from environmental sample extracts. PCR amplification of genomic DNA from Gaedo water samples using dinoflagellate-specific SSU rDNA primers yielded 280 clones, which were screened by closed tube PCR-melting curve analysis targeting a

Tae-Gyu Park; Gi-Hong Park; Young-Tae Park; Yang-Soon Kang; Heon-Meen Bae; Chang-Hoon Kim; Hae-Jin Jeong; Yoon Lee



Bayesian analysis for nonlinear regression model under skewed errors, with application in growth curves.  


We have considered a Bayesian approach for the nonlinear regression model by replacing the normal distribution on the error term by some skewed distributions, which account for both skewness and heavy tails or skewness alone. The type of data considered in this paper concerns repeated measurements taken in time on a set of individuals. Such multiple observations on the same individual generally produce serially correlated outcomes. Thus, additionally, our model does allow for a correlation between observations made from the same individual. We have illustrated the procedure using a data set to study the growth curves of a clinic measurement of a group of pregnant women from an obstetrics clinic in Santiago, Chile. Parameter estimation and prediction were carried out using appropriate posterior simulation schemes based in Markov Chain Monte Carlo methods. Besides the deviance information criterion (DIC) and the conditional predictive ordinate (CPO), we suggest the use of proper scoring rules based on the posterior predictive distribution for comparing models. For our data set, all these criteria chose the skew-t model as the best model for the errors. These DIC and CPO criteria are also validated, for the model proposed here, through a simulation study. As a conclusion of this study, the DIC criterion is not trustful for this kind of complex model. PMID:19629998

De la Cruz, Rolando; Branco, Márcia D



Numerical analysis of thermal creep flow in curved channels for designing a prototype of Knudsen micropump  

NASA Astrophysics Data System (ADS)

The possibility to generate a gas flow inside a channel just by imposing a tangential temperature gradient along the walls without the existence of an initial pressure difference is well known. The gas must be under rarefied conditions, meaning that the system must operate between the slip and the free molecular flow regimes, either at low pressure or/and at micro/nano-scale dimensions. This phenomenon is at the basis of the operation principle of Knudsen pumps, which are actually compressors without any moving parts. Nowadays, gas flows in the slip flow regime through microchannels can be modeled using commercial Computational Fluid Dynamics softwares, because in this regime the compressible Navier-Stokes equations with appropriate boundary conditions are still valid. A simulation procedure has been developed for the modeling of thermal creep flow using ANSYS Fluent®. The implementation of the boundary conditions is achieved by developing User Defined Functions (UDFs) by means of C++ routines. The complete first order velocity slip boundary condition, including the thermal creep effects due to the axial temperature gradient and the effect of the wall curvature, and the temperature jump boundary condition are applied. The developed simulation tool is used for the preliminary design of Knudsen micropumps consisting of a sequence of curved and straight channels.

Leontidis, V.; Brandner, J. J.; Baldas, L.; Colin, S.



Multivariate curve resolution for the analysis of remotely sensed thermal infrared hyperspectral images.  

SciTech Connect

While hyperspectral imaging systems are increasingly used in remote sensing and offer enhanced scene characterization relative to univariate and multispectral technologies, it has proven difficult in practice to extract all of the useful information from these systems due to overwhelming data volume, confounding atmospheric effects, and the limited a priori knowledge regarding the scene. The need exists for the ability to perform rapid and comprehensive data exploitation of remotely sensed hyperspectral imagery. To address this need, this paper describes the application of a fast and rigorous multivariate curve resolution (MCR) algorithm to remotely sensed thermal infrared hyperspectral images. Employing minimal a priori knowledge, notably non-negativity constraints on the extracted endmember profiles and a constant abundance constraint for the atmospheric upwelling component, it is demonstrated that MCR can successfully compensate thermal infrared hyperspectral images for atmospheric upwelling and, thereby, transmittance effects. We take a semi-synthetic approach to obtaining image data containing gas plumes by adding emission gas signals onto real hyperspectral images. MCR can accurately estimate the relative spectral absorption coefficients and thermal contrast distribution of an ammonia gas plume component added near the minimum detectable quantity.

Haaland, David Michael; Stork, Christopher Lyle; Keenan, Michael Robert



Development of oral reading fluency in children with speech or language impairments: A growth curve analysis  

PubMed Central

This longitudinal study used piece-wise growth curve analyses to examine growth patterns in oral reading fluency for students diagnosed with speech (SI) or language impairments (LI) from first through third grade (N = 1,991). The main finding of this study was that a diagnosis of SI or LI can have a detrimental effect on early reading skills and these problems can be persistent. The results indicate differences between subgroups in growth trajectories that were evident in first grade. These differences were associated with a students’ speech or language status. A large proportion of students with SI or LI did not meet grade-level reading fluency benchmarks. Overall students with SI showed better performance than students with LI. Reading fluency performance was negatively related to the persistence of the SI or LI; the lowest performing students were those originally identified with SI or LI whose diagnosis changed to a learning disability. The results underscore the need to identify, monitor, and address reading fluency difficulties early among students with SI or LI.

Puranik, Cynthia S.; Petscher, Yaacov; Al Otaiba, Stephanie; Catts, Hugh W.; Lonigan, Christopher J.



Dynamical x-ray diffraction from nonuniform crystalline films: Application to x-ray rocking curve analysis  

SciTech Connect

A dynamical model for the general case of Bragg x-ray diffraction from arbitrarily thick nonuniform crystalline films is presented. The model incorporates depth-dependent strain and a spherically symmetric Gaussian distribution of randomly displaced atoms and can be applied to the rocking curve analysis of ion-damaged single crystals and strained layer superlattices. The analysis of x-ray rocking curves using this model provides detailed strain and damage depth distributions for ion-implanted or MeV-ion-bombarded crystals and layer thickness, and lattice strain distributions for epitaxial layers and superlattices. The computation time using the dynamical model is comparable to that using a kinematical model. We also present detailed strain and damage depth distributions in MeV-ion-bombarded GaAs(100) crystals. The perpendicular strain at the sample surface, measured as a function of ion-beam dose (D), nuclear stopping power (S/sub n/), and electronic stopping power (S/sub e/) is shown to vary according to (1-kS/sub e/)DS/sub n/ and saturate at high doses.

Wie, C.R.; Tombrello, T.A.; Vreeland T. Jr.



The Impact of Tides on Transiting Planet Structure and Evolution and Light Curve Analysis.  

NASA Astrophysics Data System (ADS)

We examine two key consequences of tidal forces on the transiting planet observed and theoretical properties. First, based on consistent calculations coupling gravothermal evolution with complete tidal equations, we revisit the viability of the tidal heating hypothesis to explain the anomalously large radius of some transiting planets. We demonstrate, both analytically and numerically, that calculations based on tidal models truncated at second order in eccentricity, as done in all previous studies, lead to severely erroneous tidal evolutions. Such truncated calculations yield characteristic timescales for dynamical evolution that can be wrong by orders of magnitude, leading accordingly to completely erroneous tidal energy dissipation rates during the planet's evolution. We demontrate that these results do not stem from uncertainties in the tidal quality factor, as often (erroneously) suggested, but from the exact calculations of the tidal equations. We show that, although tidal heating provides a substantial contribution to the planet's heat budget, this mechanism can not explain alone all the anomalously inflated planets. We examine alternative mechanisms to explain these puzzling properties. Furthermore, due to strong tidal forces, transiting planets exhibit a non-spherical shape. Such a departure from sphericity has a measurable impact on the observed transit depth and leads to a bias in the derivation of the transit radius from the light curve. As the tidally deformed planet projects its smallest cross section area during the transit, the measured effective radius is smaller than the one of the unperturbed genuine spherical planet. To correct this bias, we present analytical expressions that can easily be used to calculate the shape of observed planets (and Love number) and its impact on the transit lightcurve. These expressions enable us to convert the planet’s measured cross section into its real equilibrium radius, the one to be used when comparing measurements with theoretical models.

Chabrier, Gilles



Association of gingival recession and other factors with the presence of dentin hypersensitivity.  


Dentin hypersensitivity (DH) may be present in association with gingival recession. The aim of this study was to determine quantitatively the association of gingival recession and other factors with the presence of DH. One hundred and four Japanese subjects with or without gingival recession were randomly selected. Intact canines and/or first premolars in both maxillary and mandibular quadrants were analyzed. Gingival recession was measured as a vertical length at the buccal site of the teeth. DH was recorded as an ordered categorical variable registering four increasing levels of pain after cold stimulation; from no discomfort to severe pain during and after stimulation (DH1, 2, 3, and 4). Association of DH with periodontal parameters and daily lifestyle was also investigated. Tooth-based analysis of 446 teeth from 104 subjects revealed that DH level was significantly higher in recessive teeth (1, 2, 3, and 4-8 mm) than in non-recessive teeth (0 mm). DH-positive rate in non-recessive teeth was only 18 % (DH1; 14 %, DH2; 3 %, and DH3; 1 %). Highest DH level was observed in teeth with severe recession (4-8 mm), showing DH0; 21 %, DH1; 33 %, DH2; 31 %, and DH3; 15 %. Recession-dependent increase in DH was observed, showing 18, 49, 52, 60, and 79 % DH-positive in teeth with 0, 1, 2, 3, and 4-8 mm recession, respectively. Plaque-free teeth showed a higher DH level than plaque-stained teeth, suggesting that good plaque control may be associated with the presence of DH. There were no significant differences in DH of teeth on the basis of smoking, probing depth, and bleeding on probing. Multiple logistic regression analysis revealed that gingival recession [odds ratio (OR) = 10.2, 95 % confidence interval (CI) = 5.5-18.9] and plaque deposition (OR = 0.3, 95 % CI = 0.2-0.5) were significant contributors to DH. Multilevel modeling analysis revealed that not only gingival recession and plaque deposition but also V-shaped cervical notch and tooth brushing frequency were associated with DH. These results demonstrate that the progression of gingival recession, plaque-free teeth, V-shaped cervical notch, and frequent brushing may be significant predictors of DH in canines and first premolars. PMID:23283584

Fukumoto, Yoshikazu; Horibe, Masumi; Inagaki, Yuji; Oishi, Keiji; Tamaki, Naofumi; Ito, Hiro-O; Nagata, Toshihiko



Load control-strain control isochronous stress-strain curves for high temperature nonlinear analysis  

SciTech Connect

Aircraft gas turbine components are subjected to severe operating conditions. High temperatures, large thermal strains, and mechanical loads combine to cause the materials to undergo significant nonlinear behavior. In order to assure safe, durable components, it is necessary that analysis methods be available to predict the nonlinear deformation. General purpose finite element codes are available for perform elastic and viscoplastic analyses, but the analyses are expensive. Both large plastic and creep strain analyses can require significant computer resources, but typically a plastic solution is more economical to run than a time-stepping creep or viscoplastic model solution. For those applications where the deformation is principally time dependent, it is advantageous to include time-dependent creep effects in a ``constant time`` or ``isochronous`` analysis. Although this approach has been used in the past to estimate rupture life, this paper will present several significant new techniques for doing an isochronous analysis to analyze time-dependent deformation.

Bechtel, G.S.; Cook, T.S. [GE Aircraft Engines, Cincinnati, OH (United States)



Have Employment Patterns in Recessions Changed?.  

ERIC Educational Resources Information Center

A survey of postwar recessions shows that the increasing proportion of service sector jobs has moderated overall employment declines and that women in nontraditional jobs, Blacks, and youths bear a disproportionate share of job losses. (LRA)

Bowers, Norman



Football curves  

NASA Astrophysics Data System (ADS)

Straight lines, zigzag, parabolas (possibly truncated), circles and spirals are the main curves which can be observed in football (in the European sense, soccer elsewhere). They are, respectively, associated to heavy kick, knuckleball, lob and banana kicks. We discuss their physical origin and determine their respective domain of existence.

Dupeux, Guillaume; Cohen, Caroline; Le Goff, Anne; Quéré, David; Clanet, Christophe



Robust strategies for automated AFM force curve analysis--I. Non-adhesive indentation of soft, inhomogeneous materials.  


The atomic force microscope (AFM) has found wide applicability as a nanoindentation tool to measure local elastic properties of soft materials. An automated approach to the processing of AFM indentation data, namely, the extraction of Young's modulus, is essential to realizing the high-throughput potential of the instrument as an elasticity probe for typical soft materials that exhibit inhomogeneity at microscopic scales. This paper focuses on Hertzian analysis techniques, which are applicable to linear elastic indentation. We compiled a series of synergistic strategies into an algorithm that overcomes many of the complications that have previously impeded efforts to automate the fitting of contact mechanics models to indentation data. AFM raster data sets containing up to 1024 individual force-displacement curves and macroscopic compression data were obtained from testing polyvinyl alcohol gels of known composition. Local elastic properties of tissue-engineered cartilage were also measured by the AFM. All AFM data sets were processed using customized software based on the algorithm, and the extracted values of Young's modulus were compared to those obtained by macroscopic testing. Accuracy of the technique was verified by the good agreement between values of Young's modulus obtained by AFM and by direct compression of the synthetic gels. Validation of robustness was achieved by successfully fitting the vastly different types of force curves generated from the indentation of tissue-engineered cartilage. For AFM indentation data that are amenable to Hertzian analysis, the method presented here minimizes subjectivity in preprocessing and allows for improved consistency and minimized user intervention. Automated, large-scale analysis of indentation data holds tremendous potential in bioengineering applications, such as high-resolution elasticity mapping of natural and artificial tissues. PMID:17536911

Lin, David C; Dimitriadis, Emilios K; Horkay, Ferenc



In-Situ Investigation of Hot Tearing in Aluminum Alloy AA1050 via Acoustic Emission and Cooling Curve Analysis  

NASA Astrophysics Data System (ADS)

Hot tearing in the AA1050 alloy was investigated in real time and in situ using acoustic emission (AE) and cooling curve analysis techniques and a ring mold. Activities involving AE have been detected in three zones of the solidification curve. The characteristic signals for hot tearing were an AE energy of over 600 e.u. and an average frequency of 125 ± 15 kHz in zone II. For hot cracking, the AE energy was over 650 e.u. and the average frequency was 128 ± 17 kHz in zone III. The hot-tear start temperature ranged from 636 °C to 653 °C; the nonequilibrium solidus T' S , from 556 °C to 614 °C; the fraction solid at hot-tear onset from 0.71 to 0.99; and the Clyne-Davis hot-tear susceptibility coefficient (HSC) from 0.25 to 0.81. The HSC correlated inversely with a total energy of solidification cracking ( E total) {text{HSC}} \\cong 167left( {E_{text{total}} } right)^{ - 0.8}. A hot-tear susceptibility factor (HSF) = (pct Fe)·(cooling rate (CR))2 was related to the HSC and T' S as HSC = 0.002 HSF + 0.3 and T' S = -0.3 HSF + 617.

Pekguleryuz, M. O.; Li, X.; Aliravci, C. A.



Analysis of progress curves for enzyme-catalysed reactions. Automatic construction of computer programs for fitting integrated rate equations.  

PubMed Central

The computer analysis of progress curves for enzyme-catalysed reactions involves a series of mathematical and computational tasks. The three most daunting of these are the derivation of an integrated rate equation, solving this equation so that the amount of product formed by the reaction at any time can be calculated, and incorporating this solution into a non-linear-regression computer program. This paper describes the basis of a computer program that greatly simplifies the problem. The proposed mechanism is specified in the familiar kinetic constant form, which is automatically translated into a program capable of fitting this mechanism to a series of experimental progress curves. The approach is illustrated for a reversible reaction with one substrate and one product, and tested with some data obtained for the fumarase reaction. A copy of the program has been deposited as Supplementary Publication SUP 50148 (13 pages) at the British Library Document Supply Centre, Boston Spa, Wetherby, West Yorkshire LS23 7BQ, U.K., from whom copies can be obtained on the terms indicated in Biochem. J. (1989) 257, 5.

Duggleby, R G; Wood, C



Real-Time PCR and Melting Curve Analysis for Reliable and Rapid Detection of SHV Extended-Spectrum ?-Lactamases  

PubMed Central

Extended-spectrum ?-lactamases (ESBLs), e.g., ESBLs of the TEM or SHV type, compromise the efficacies of expanded-spectrum cephalosporins. An SHV non-ESBL that hydrolyzes only narrow-spectrum cephalosporins can be converted into an SHV ESBL through substitutions at three amino acid positions, 179, 238, or 238–240. In order to improve detection of SHV ESBLs, a novel method, based on real-time PCR monitored with fluorescently labeled hybridization probes and followed by melting curve analysis, was developed. It is able to (i) detect blaSHV genes with high degrees of sensitivity and specificity, (ii) discriminate between blaSHV non-ESBL and blaSHV ESBL, and (iii) categorize the SHV ESBL producers into three phenotypically relevant subgroups. This method, termed the SHV melting curve mutation detection method, represents a powerful tool for epidemiological studies with SHV ESBLs. It even has the potential to be used in the diagnostic microbiology laboratory, because up to 32 clinical isolates can be processed in less than 1 h by starting with just a few bacterial colonies.

Randegger, Corinne C.; Hachler, Herbert



[Proximal autosomal recessive types of spinal muscular atrophy].  


One hundred and three patients with spinal muscular atrophy (SMA) were registered in a population medical genetic study of autosomal recessive childhood proximal SMA in Saratov region. Twenty-five patients were investigated complexly, using biochemical analysis of some enzymes, electroneuromyography, magnetic resonance imaging of spinal cord, muscle biopsy and molecular genetic testing. Pronounced clinical polymorphism and genetic heterogeneity of the disease were revealed. PMID:14564781

Kolokolov, O V; Iudina, G K; Solovykh, N N; Evgrafov, O V



SACCHAROMYCES CEREVISIAE Recessive Suppressor That Circumvents Phosphatidylserine Deficiency  

PubMed Central

Phenotypic reversion of six independent Saccharomyces cerevisiae cho1 mutants was shown to be due predominantly to mutation of an unlinked gene, eam1. The eam1 gene was located very close to ino1 on chromosome X by meiotic tetrad analysis. Recessive eam1 mutations did not correct the primary cho1 defect in phosphatidylserine synthesis but made endogenous ethanolamine available for sustained nitrogenous phospholipid synthesis. A novel biochemical contribution to nitrogenous lipid synthesis is indicated by the eam1 mutants.

Atkinson, Katharine D.



The recession of 1990: An Austrian explanation  

Microsoft Academic Search

Conclusion  Deficit spending and money-supply expansion do not eliminate recessions. Theycause recessions. This fact will never be understood unless economists and government policymakers stop trying to micro-manage\\u000a the economy, and start studying what their actions are doing to the structure of production. Heavy inflation of the money\\u000a supply followed by sharp cutbacks change the rules right in the middle of the

Arthur Middleton Hughes



Uncertainty Analysis of Bivariate Drought Frequency Curve Using Copula-Based Random Generation  

NASA Astrophysics Data System (ADS)

Several works have been performed to capture the joint behaviors of drought based on hydro-meteorological observations and hydro-statistical models. However, in general, hydro-meteorological observations such as rainfalls are quite limited for reliable analyses due to their short length of records, especially bivariate drought analyses. To address this limitation, this study introduces copulas to generate random variables used in drought analyses. As applied in previous studies, Copulas are employed in this study to facilitate the identification and construction of dependence structure of droughts in South Korea. After copulas construct the joint distribution of drought-related variables, monthly rainfalls are generated to preserve randomness as well as the dependent structure of drought. The rainfall data generated by copula-based random generation provides a probability-based description of the overall drought status through bivariate drought frequency analysis. The bivariate frequency analysis is performed in this study to quantify the relationship between duration and severity of drought in statistical scheme. The estimates of drought severity and their uncertainties acquired from the bivariate drought frequency analysis are discussed in this study. The results indicate that the use of copulas allows the construction and generation of inter and/or intra-variable drought variables to enhance the bivariate drought frequency analysis.

Kim, T.; Yoo, J.; Kim, U.; Ahn, J.



COLD-PCR enhanced melting curve analysis improves diagnostic accuracy for KRAS mutations in colorectal carcinoma  

Microsoft Academic Search

BACKGROUND: KRAS mutational analysis is the standard of care prior to initiation of treatments targeting the epidermal growth factor receptor (EGFR) in patients with metastatic colorectal cancer. Sensitive methods are required to reliably detect KRAS mutations in tumor samples due to admixture with non-mutated cells. Many laboratories have implemented sensitive tests for KRAS mutations, but the methods often require expensive

Colin C Pritchard; Laura Akagi; Poluru L Reddy; Loren Joseph; Jonathan F Tait



Nonlinear stress analysis for bonded patch to curved thin-walled structures  

Microsoft Academic Search

Adhesive bonding has been widely used to join or repair metallic and composite structural components to achieve or restore their designated structural stiffness and strengths. However, current analysis methods and empirical databases for composite bonded joint design and composite bonded patch repair are limited to flat plate and\\/or flat laminate geometries, and the effects of curvature on the performance and

Liyong Tong; Xiannian Sun



Maintaining health insurance during a recession: likely COBRA eligibility: an updated analysis using the Commonwealth Fund 2007 Biennial Health Insurance Survey.  


As the U.S. economic downturn continues and job losses mount, more working Americans are likely to lose access to affordable health benefits subsidized by their employers. Analysis of the 2007 Commonwealth Fund Biennial Health Insurance Survey finds that two of three working adults would be eligible to extend job-based coverage, under the 1985 Consolidated Omnibus Budget Reconciliation Act (COBRA) if they became unemployed. Under COBRA, however, unemployed workers would have to pay four to six times their current contribution at a time of sharply reduced income. In fact, the latest national figures indicate that, because of high premiums, only 9 percent of unemployed workers have COBRA coverage. Substantial financial assistance of 75 percent to 85 percent of premiums could help laid-off workers maintain coverage. In addition, expansion of Medicaid and the State Children's Health Insurance Program would benefit low-income, laid-off workers and their families who are ineligible for COBRA. PMID:19288628

Doty, Michelle; Rustgi, Sheila D; Schoen, Cathy; Collins, Sara R



Growth curve analysis for plasma profiles using smoothing splines. Final report, January 1993--January 1995  

SciTech Connect

In this project, we parameterize the shape and magnitude of the temperature and density profiles on JET and the temperature profiles on TFTR. The key control variables for the profiles were tabulated and the response functions were estimated. A sophisticated statistical analysis code was developed to fit the plasma profiles. Our analysis indicate that the JET density shape depends primarily on {bar n}/B{sub t} for Ohmic heating, {bar n} for L-mode and I{sub p} for H-mode. The temperature profiles for JET are mainly determined by q{sub 95} for the case of Ohmic heating, and by B{sub t} and P/{bar n} for the L-mode. For the H-mode the shape depends on the type of auxiliary heating, Z{sub eff}, N{bar n}, q{sub 95}, and P.

Imre, K.



An STR melt curve genotyping assay for forensic analysis employing an intercalating dye probe FRET.  


The most common markers used in forensic genetics are short tandem repeats (STRs), the alleles of which are separated and analyzed by length using capillary electrophoresis (CE). In this work, proof of concept of a unique STR genotyping approach has been demonstrated using asymmetric PCR and a fluorescence resonance energy transfer (FRET)-based hybridization analysis that combines fluorophore-labeled allele-specific probes and a DNA intercalating dye (dpFRET) in a melt match/mismatch analysis format. The system was successfully tested against both a simple (TPOX) and a complex (D3S1358) loci, demonstrated a preliminary detection limit of <10 genomic equivalents with no allelic dropout and mixture identification in both laboratory-generated and clinical samples. With additional development, this approach has the potential to contribute to advancing the use of STR loci for forensic applications and related fields. PMID:20840288

Halpern, Micah D; Ballantyne, Jack



New light curves and analysis of the short-period Algol XZ Canis Minoris  

NASA Astrophysics Data System (ADS)

We present new observations of the short-period Algol XZ Canis Minoris made between 25 Dec. 1992 and 1 Mar. 1993. Two new epochs of minimum light were determined and an improved ephemeris is given. Analysis of the observations with the latest version of the Wilson-Devinney program shows that the system is semidetached. Our solution does not indicate the presence of third light, whereas some previously published solutions required large amounts of third light.

Terrell, Dirk; Gunn, J. B.; Kaiser, Daniel H.



InTube DNA Methylation Profiling by Fluorescence Melting Curve Analysis  

Microsoft Academic Search

Background: Most PCR assays for detection of 5-meth- ylcytosine in genomic DNA entail a two-step procedure, comprising initial PCR amplification and subsequent product analysis in separate operations that usually require manual transfer. These methods generally pro- vide information about methylation of only a few CpG dinucleotides within the target sequence. Methods: An in-tube methylation assay is described that integrates amplification

Jesper Worm; Anni Aggerholm; Per Guldberg



Molecular component distribution imaging of living cells by multivariate curve resolution analysis of space-resolved Raman spectra.  


ABSTRACT. Label-free Raman microspectroscopy combined with a multivariate curve resolution (MCR) analysis can be a powerful tool for studying a wide range of biomedical molecular systems. The MCR with the alternating least squares (MCR-ALS) technique, which retrieves the pure component spectra from complicatedly overlapped spectra, has been successfully applied to in vivo and molecular-level analysis of living cells. The principles of the MCR-ALS analysis are reviewed with a model system of titanium oxide crystal polymorphs, followed by two examples of in vivo Raman imaging studies of living yeast cells, fission yeast, and budding yeast. Due to the non-negative matrix factorization algorithm used in the MCR-ALS analysis, the spectral information derived from this technique is just ready for physical and/or chemical interpretations. The corresponding concentration profiles provide the molecular component distribution images (MCDIs) that are vitally important for elucidating life at the molecular level, as stated by Schroedinger in his famous book, "What is life?" Without any a priori knowledge about spectral profiles, time- and space-resolved Raman measurements of a dividing fission yeast cell with the MCR-ALS elucidate the dynamic changes of major cellular components (lipids, proteins, and polysaccharides) during the cell cycle. The MCR-ALS technique also resolves broadly overlapped OH stretch Raman bands of water, clearly indicating the existence of organelle-specific water structures in a living budding yeast cell. PMID:24108582

Ando, Masahiro; Hamaguchi, Hiro-O



Analysis of CoRoT N2-light curves corrected with a new quasi-automatic procedure  

NASA Astrophysics Data System (ADS)

This work is devoted to the analysis of CoRoT light curves to which we apply a new quasi-automatic procedure we have developed. This IDL procedure corrects the abnormal jumps and the instrumental drifts which survived in N2-exoplanet data. The method we present can be used for the CoRoT targets observed through exoplanets channel. We study 3 stars already considered by Alecian et al. (2009) who used less sophisticated methods for corrections and an older release of the N2 data. With our method, we succeed to remove random jumps and systematic trends encountered in typical CoRoT data. We describe the algorithm and compare our new results to the old ones, published in 2009.

Ghazaryan, S. A.; Alecian, G.; Harutyunyan, H. A.



A Latent Growth Curve Analysis of Early and Increasing Peer Victimization as Predictors of Mental Health Across Elementary School  

PubMed Central

Peer victimization has been implicated as a traumatic stressor that compromises children’s long-term mental health, yet a dearth of prospective research specifically demonstrates lasting effects of early victimization. This research examined whether early (2nd grade) victimization and increasing (2nd – 5th grade) victimization independently predicted depressive symptoms and aggressive behavior (overt and relational) in 5th grade. Participants included 433 children (238 girls, 195 boys). Children reported on peer victimization and depressive symptoms; teachers reported on peer victimization and aggressive behavior. Latent growth curve analysis revealed that both early and increasing victimization made unique contributions to subsequent depressive symptoms and aggressive behavior. Relational aggression was particularly likely to follow victimization in girls.

Rudolph, Karen D.; Troop-Gordon, Wendy; Hessel, Elenda T.; Schmidt, Jennifer D.



How fast does the Grim Reaper walk? Receiver operating characteristics curve analysis in healthy men aged 70 and over  

PubMed Central

Objective To determine the speed at which the Grim Reaper (or Death) walks. Design Population based prospective study. Setting Older community dwelling men living in Sydney, Australia. Participants 1705 men aged 70 or more participating in CHAMP (Concord Health and Ageing in Men Project). Main outcome measures Walking speed (m/s) and mortality. Receiver operating characteristics curve analysis was used to calculate the area under the curve for walking speed and determine the walking speed of the Grim Reaper. The optimal walking speed was estimated using the Youden index (sensitivity+specificity?1), a common summary measure of the receiver operating characteristics curve, and represents the maximum potential effectiveness of a marker. Results The mean walking speed was 0.88 (range 0.15-1.60) m/s. The highest Youden index (0.293) was observed at a walking speed of 0.82 m/s (2 miles (about 3 km) per hour), corresponding to a sensitivity of 63% and a specificity of 70% for mortality. Survival analysis showed that older men who walked faster than 0.82 m/s were 1.23 times less likely to die (95% confidence interval 1.10 to 1.37) than those who walked slower (P=0.0003). A sensitivity of 1.0 was obtained when a walking speed of 1.36 m/s (3 miles (about 5 km) per hour) or greater was used, indicating that no men with walking speeds of 1.36 m/s or greater had contact with Death. Conclusion The Grim Reaper’s preferred walking speed is 0.82 m/s (2 miles (about 3 km) per hour) under working conditions. As none of the men in the study with walking speeds of 1.36 m/s (3 miles (about 5 km) per hour) or greater had contact with Death, this seems to be the Grim Reaper’s most likely maximum speed; for those wishing to avoid their allotted fate, this would be the advised walking speed.



Single nucleotide polymorphism detection in aldehyde dehydrogenase 2 (ALDH2) gene using bacterial magnetic particles based on dissociation curve analysis.  


Single nucleotide polymorphism (SNP) detection for aldehyde dehydrogenase 2 (ALDH2) gene based on DNA thermal dissociation curve analysis was successfully demonstrated using an automated system with bacterial magnetic particles (BMPs) by developing a new method for avoiding light scattering caused by nanometer-size particles when using commercially available fluorescent dyes such as FITC, Cy3, and Cy5 as labeling chromophores. Biotin-labeled PCR products in ALDH2, two allele-specific probes (Cy3-labeled detection probe for ALDH2*1 and Cy5-labeled detection probe for ALDH2*2), streptavidin-immobilized BMPs (SA-BMPs) were simultaneously mixed. The mixture was denatured at 70 degrees C for 3 min, cooled slowly to 25 degrees C, and incubated for 10 min, allowing the DNA duplex to form between Cy3- or Cy5-labeled detection probes and biotin-labeled PCR products on SA-BMPs. Then duplex DNA-BMP complex was heated to 58 degrees C, a temperature determined by dissociation curve analysis and a dissociated single-base mismatched detection probe was removed at the same temperature under precise control. Furthermore, fluorescence signal from the detection probe was liberated into the supernatant from completely matched duplex DNA-BMP complex by heating to 80 degrees C and measured. In the homozygote target DNA (ALDH2*1/*1 and ALDH2*2/*2), the fluorescence signals from single-base mismatched were decreased to background level, indicating that mismatched hybridization was efficiently removed by the washing process. In the heterozygote target DNA (ALDH2*1/*2), each fluorescence signals was at a similar level. Therefore, three genotypes of SNP in ALDH2 gene were detected using the automated detection system with BMPs. PMID:15329927

Maruyama, Kohei; Takeyama, Haruko; Nemoto, Etsuo; Tanaka, Tsuyoshi; Yoda, Kiyoshi; Matsunaga, Tadashi



Assessing catchment hydrological functioning using discharge recession analysis based on the Kirchner's method. A case study in the Ardèche catchment (France)  

NASA Astrophysics Data System (ADS)

Catchments show a high degree of heterogeneity and variability, both in space and time. In order to deal with spatial heterogeneity and process variability in more efficient and more "natural and realistic" manner, model simplifications are needed. Governing equations such as the Darcy or Richards' equation, which are inherent in many hydrological models, are suitable for local scales. However, their application at much larger scales (e.g. catchment scale) remains problematic. The linear reservoir is a well-known and common approach in many catchment-based hydrological models. However, reality shows that those linear equations might not be representative enough for describing hydrological catchment behavior. Kirchner (2009), proposed a simple approach representing catchment behavior as a non-linear reservoir model, assuming that discharge at the outlet is only a function of catchment storage. He also proposed a method to determine non-linear reservoir parameters for this simple bucket model. The objective of this study is to investigate whether this approach is applicable to the Ardèche catchment (2355 km2), located in the southern part of France. The catchment is influenced by a Mediterranean climate with seasonal heavy rainfall events during autumn. The northern and north-western part of the catchment is characterized by steep slopes and igneous and metamorphic rock formations. A further objective is to relate the estimated parameters of the first-order dynamical system to catchment characteristics, in order to be able to develop a distributed model, adapted to the catchment response variability. The challenge for the Kirchner's method is the high geological and pedological heterogeneity of the Ardèche basin. We apply the Kirchner's method to 6 sub-catchments of the Ardèche ranging from 3.9 to 200 km2 using hourly rainfall and discharge data, in order to identify the discharge sensitivity function. We use the obtained corresponding parameters in a simple bucket model similar to the one proposed by Kirchner (2009). To have more representative potential evapotranspiration data used in the model, we introduce crop coefficient seasonality to better represent the data. Performance measurements with the Nash-Sutcliffe coefficient show performances above 80 %. These results clearly indicate that timing and magnitude of simulated discharge is correctly reproduced by the model. Additionally we assess the impact of the seasonality on the model parameterization yielding similar results in the discharge analysis. Our work shows that Kirchner's method can be applied successfully in the Ardèche catchment. Eventually, we observe that geology may be highlighted as a predictor that dominates the overall hydrological response in the basin. Kirchner, J. W. (2009), Catchments as simple dynamical systems: Catchment characterization, rainfall-runoff modeling, and doing hydrology backward, Water Resour. Res., 45, W02429, doi:10.1029/2008WR006912

Adamovic, Marko; Braud, Isabelle; Branger, Flora; Krier, Robert



Models for recession flows in the upper Blue Nile River  

Microsoft Academic Search

Stream-flow recessions are commonly characterized by the exponential equation or in the alternative power form equation of a single linear reservoir. The most common measure of recession is the recession constant K, which relates to the power function form of the recession equation for a linear reservoir. However, in reality it can be seen that the groundwater dynamics of even

A. Mishra; T. Hata; A. W. Abdelhadi



Ambipolar conduction in recessed channel Schottky barrier MOSFETs  

Microsoft Academic Search

The ambipolar conduction is numerically studied in recessed channel Schottky barrier MOSFET (RC-SBMOS). The results show that the recessed channel structure can alleviate the lateral field penetrations coming from drain electrode. Thus, it is rather insensitive to the variations of drain voltages. However, the parasitic recessed channel leads to a lower on-state driving current. The depth of the recessed channel

Chun-Hsing Shih; Shao-Hui Yang; Ruei-Kai Shia; Nguyen Dang Chien



The Impact of the Great Recession on Community-Based Mental Health Organizations: An Analysis of Top Managers' Perceptions of the Economic Downturn's Effects and Adaptive Strategies Used to Manage the Consequences in Ohio.  


The Great Recession of 2007-2009 adversely affected the financial stability of the community-based mental health infrastructure in Ohio. This paper presents survey results of the type of adaptive strategies used by Ohio community-based mental health organizations to manage the consequences of the economic downturn. Results were aggregated into geographical classifications of rural, mid-sized urban, and urban. Across all groups, respondents perceived, to varying degrees, that the Great Recession posed a threat to their organization's survival. Urban organizations were more likely to implement adaptive strategies to expand operations while rural and midsized urban organizations implemented strategies to enhance internal efficiencies. PMID:23408296

Sweeney, Helen Anne; Knudsen, Kraig



High-resolution melting curve analysis for genotyping of common SNP in MTHFR gene using fixed-cell suspension.  


Genetic variation in MTHFR might explain the interindividual differences in both therapeutic and toxic responses to the treatment of cancer and rheumatoid arthritis with methotrexate, and can be involved in the sensitivity of developing diseases like cancer and congenital anomalies. We investigated the common sequence variation, C677T, in the MTHFR gene in fixed-cell specimens archived after chromosomal analysis using a novel gene scanning method based on post PCR analysis of high-resolution melting curves (HRM). These fixed specimens were stored after routine chromosomal analysis for 1 year at -20 degrees C in a 3:1 methanol:acetic acid solution. The method revealed a distinct pattern between homozygous and heterozygous alleles. Sensitivity and specificity of the HRM based method were comparable to that obtained by a hybridization probe. While the success rate for genotyping of a common SNP in MTHFR was similar to the hybridization probe approach, the HRM based method was more cost-effective and had a shorter turnaround time. PMID:18725286

Sinthuwiwat, Thivaratana; Poowasanpetch, Phanasit; Wongngamrungroj, Angsana; Promso, Somying; Auewarakul, Chirayu; Mooney, Sean; Tocharoentanaphol, Chintana



Personal dose analysis of TLD glow curve data from individual monitoring records.  


Radiation exposure of workers in Ghana have been estimated on the basis of personal dose records of the occupationally exposed in medical, industrial and research/teaching practices for the period 2008-09. The estimated effective doses for 2008 are 0.400, 0.495 and 0.426 mSv for medical, industrial and research/teaching practices, respectively. The corresponding collective effective doses are 0.128, 0.044 and 0.017 person-Sv, respectively. Similarly, the effective doses recorded in 2009 are 0.448, 0.545 and 0.388 mSv, respectively with corresponding collective effective doses of 0.108, 0.032 and 0.012 person-Sv, respectively. The study shows that occupational exposure in Ghana is skewed to the lower doses (between 0.001 and 0.500 mSv). A statistical analysis of the effective doses showed no significant difference at p < 0.05 among the means of the effective doses recorded in various practices. PMID:22611206

Adjei, D; Darko, E O; Schandorf, C; Owusu-Manteaw, P; Akrobortu, E



Improved Inhibitor Screening Experiments by Comparative Analysis of Simulated Enzyme Progress Curves  

PubMed Central

A difficulty associated with high throughput screening for enzyme inhibitors is to establish reaction conditions that maximize the sensitivity and resolution of the assay. Deduction of information from end-point assays at single concentrations requires a detailed understanding of the time progress of the enzymatic reaction, an essential but often difficult process to model. A tool to simulate the time progress of enzyme catalyzed reactions and allows adjustment of reactant concentrations and parameters (initial concentrations, Km, kcat, Ki values, enzyme half-life, product•enzyme dissociation constant, and the rate constant for the reversed reaction) has been developed. This tool provides comparison of the progress of uninhibited versus inhibited reactions for common inhibitory mechanisms, and guides the tuning of reaction conditions. Possible applications include: analysis of substrate turnover, identification of the point of maximum difference in product concentration (?max[P]) between inhibited and uninhibited reactions, determination of an optimal observation window unbiased for inhibitor mechanisms or potency, and interpretation of observed inhibition in terms of true inhibition. An important observation that can be utilized to improve assay signal strength and resolution is that ?max[P] occurs at a high degree of substrate consumption (commonly >75%) and that observation close to this point does not adversely affect observed inhibition or IC50 values.

Tholander, Fredrik



Analysis of Epsilon Aurigae light curve from the Solar Mass Ejection Imager  

NASA Astrophysics Data System (ADS)

The Solar Mass Ejection Imager (SMEI) was launched aboard the Coriolis spacecraft in 2003. It is equipped with 3 CCD cameras to measure the brightness of Thomson-scattered electrons in the heliosphere. Each CCD images a strip of the sky that is 3°x60°. The three cameras are mounted on the satellite with their fields of view aligned end-to-end so that SMEI sweeps nearly the entire sky each 102 minute orbit. SMEI has now accumulated stellar time series for about 5700 bright stars, including epsilon Aurigae, for each orbit where data is available. SMEI data provide nearly year-round coverage of epsilon Aurigae. The baffled SMEI optics provide more accurate photometric data than ground-based observations, particularly at mid-eclipse when epsilon Aurigae is close to the Sun. We present an analysis of the brightness variations of the epsilon Aurigae system, before and during the eclipse. The University of Denver participants are grateful for support under NSFgrant 10-16678 and the bequest of William Hershel Womble in support of astronomy at the University of Denver.

Clover, John; Jackson, B. V.; Buffington, A.; Hick, P. P.; Kloppenborg, B.; Stencel, R.




SciTech Connect

By systematically analyzing the Swift/XRT light curves detected before 2009 July, we find 19 light curves that monotonously decay as a single power law (SPL) with an index of 1 approx 1.7 from tens (or hundreds) of seconds to approx10{sup 5} s post the gamma-ray burst (GRB) trigger. They are apparently different from the canonical light curves characterized by a shallow-to-normal decay transition. We compare the observations of the prompt gamma rays and the X-rays for these two samples of GRBs (SPL vs. canonical). No statistical difference is found in the prompt gamma-ray properties for the two samples. The X-ray properties of the two samples are also similar, although the SPL sample tends to have a slightly lower neutral hydrogen absorption column for the host galaxies and a slightly larger energy release compared with the canonical sample. The SPL X-ray Telescope (XRT) light curves in the burst frame gradually merge into a conflux, and their luminosities at 10{sup 5} s are normally distributed at log L/ergs s{sup -1} = 45.6 +- 0.5. The normal decay segment of the canonical XRT light curves has the same feature. Similar to the normal decay segment, the SPL light curves satisfy the closure relations and therefore can be roughly explained with external shock models. In the scenario that the X-rays are the afterglows of the GRB fireball, our results indicate that the shallow decay would be due to energy injection into the fireball and the total energy budget after injection for both samples of GRBs is comparable. More intriguing, we find that a prior X-ray emission model proposed by Yamazaki is more straightforward to interpret the observed XRT data. We show that the zero times (T {sub 0}) of the X-rays are 10{sup 2}-10{sup 5} s prior to the GRB trigger for the canonical sample, and satisfy a log-normal distribution. The negligible T {sub 0}'s of the SPL sample are consistent with being the tail of T {sub 0} distributions at low end, suggesting that the SPL sample and the canonical sample may be from a same parent sample. Referenced to T {sub 0}, the canonical XRT light curves well trace the SPL light curves. The T {sub 0}'s of the canonical light curves in our analysis are usually much larger than the offsets of the known precursors from the main GRBs. If the prior emission hypothesis is real, the X-ray emission is better interpreted within the external shock models based on the spectral and temporal indices of the X-rays. The lack of detection of a jet-like break in most XRT light curves implies that the opening angle of the prior emission jet would be usually large.

Liang Enwei; Lue Houjun; Hou Shujin [Department of Physics, Guangxi University, Nanning 530004 (China); Zhang Binbin; Zhang Bing, E-mail:, E-mail: zhang@physics.unlv.ed [Department of Physics and Astronomy, University of Nevada, Las Vegas, NV 89154 (United States)



Coastal Bluff Recession and Impacts on Littoral Transport: Special Reference to Montauk, NY  

Microsoft Academic Search

Recession of coastal bluffs supply the initial sediment to the littoral zone along the south shore of Long Island, NY. Analysis of profile data collected as part of the Atlantic Coast of New York Monitoring Program indicated volumetric recession rates vary between headlands and coves along the Montauk province ranging from 1.0 m3\\/m\\/yr to 19.6 m3\\/m\\/yr. Stabilization of the bluffs

Frank S. Buonaiuto Jr; Henry Bokuniewicz


Aeroacoustical Study of the Tgv Pantograph Recess  

NASA Astrophysics Data System (ADS)

The general focus of this aerodynamic noise research, induced by turbulent incompressible flow, is to improve our knowledge of acoustic production mechanisms in the TGV pantograph recess in order to be able to reduce the radiated noise. This work is performed under contract with SNCF as a part of the German-French Cooperation DEUFRAKO K2, and is supported by French Ministries for Transport and Research. Previous studies on TGV noise source locations (DEUFRAKO K) have identified the pantograph recess as one of the important aerodynamic noise sources, for speeds higher than 300 km/h, due to flow separation. The pantograph recess is a very complex rectangular cavity, located both on the power car and the first coach roofs of the TGV, and has not been studied before due to the complex shapes. Its aeroacoustic features are investigated experimentally in a low-subsonic wind tunnel, on a realistic 1/7th scale mock-up both with and without pantographs. Flow velocities, estimated with hot-wire anemometry, and parietal visualizations show the flow to reattach on the recess bottom wall and to separate again at the downstream face. Wall pressure fluctuations and ``acoustic'' measurements using 1/4 and 1/2 in microphones respectively are also measured to qualify the flow: no aerodynamic or acoustic oscillations are observed. The study indicates that the pantograph recess has a different behaviour compared to the usual cavity grazing flows.

Noger, C.; Patrat, J. C.; Peube, J.; Peube, J. L.



A canine autosomal recessive model of collagen type III glomerulopathy.  


Collagen type III glomerulopathy (Col3GP) is a rare renal disease characterized by massive glomerular accumulations of collagen type III. The disease occurs in both humans and animals, and has been presumed to be heritable with an autosomal recessive inheritance pattern. The pathogenesis is unknown. We describe herein a condition of canine autosomal recessive Col3GP. This spontaneously occurring canine disease was incidentally diagnosed in six mongrel dogs. We then established and studied a pedigree segregating the disease to confirm the genetic nature and inheritance of canine Col3GP. Twenty-nine percent of offspring (14/48) were affected, strongly supporting a simple autosomal recessive inheritance pattern. Kidney specimens were studied by light microscopy, electron microscopy (EM), immunohistochemistry and in situ hybridization. Characteristic findings of Col3GP previously reported in both humans and animals were demonstrated, including massive glomerular collagen type III deposition, and evidence of local mesangial collagen type III synthesis was found. We propose that canine Col3GP may serve as an animal model of human Col3GP. Our initial studies, using simple segregation analysis, showed that the Col3A1 gene was not involved in the disease. This is the first animal model of Col3GP, and further studies of this phenotype in dogs may have the potential to provide information on the pathogenesis and genetics of the disease in both animals and humans, and may thus contribute to the development of treatment regimes. PMID:22890554

Rørtveit, Runa; Lingaas, Frode; Bønsdorff, Tina; Eggertsdóttir, Anna V; Grøndahl, Ann M; Thomassen, Ragnar; Fogo, Agnes B; Jansen, Johan H



Improved double-recessed 4H-SiC MESFETs structure with recessed source\\/drain drift region  

Microsoft Academic Search

An improved double-recessed 4H-SiC MESFETs structure with recessed source\\/drain drift region was proposed. The recessed source\\/drain drift region is to reduce channel thickness between gate and drain as well as eliminate gate depletion layer extension to source\\/drain. The recessed source\\/drain drift region of the proposed structure can be realized with the formation of double-recessed gate region. The simulated results showed

Jinping Zhang; Xiaorong Luo; Zhaoji Li; Bo Zhang



Moment-method analysis of printed wire spirals using curved piecewise sinusoidal subdomain basis and testing functions  

Microsoft Academic Search

Archimedian and logarithmic printed wire spirals are analyzed using a moment-method incorporating curved piecewise sinusoidal subdomain basis and testing functions. Results for spiral parameters including input impedance and current distribution are presented and are shown to have good agreement with published results for the same antennas obtained using linear segmentation. Since the curved basis functions exactly follow the spiral contour,

Salam K. Khamas; Gregory G. Cook



Interpretation of Surface Dynamics and Bond Strengths of Polystyrene Microspheres on a Quartz Crystal Microbalance by Analysis of Decoupling Curves  

Microsoft Academic Search

In this study we have analyzed the behavior of 5mum diameter polystyrene spheres deposited from aqueous solution on the electrode of a quartz crystal microbalance (QCM). By varying the driving voltage of the QCM, the samples exhibit a frequency response with respect to the crystal amplitude (``decoupling curve''). Decoupling curves provide information about the friction, via changes in the coupling

Iyam Lynch; Jacqueline Krim



Analysis of the stress-strain curves of a modified 9Cr-1Mo steel by the voce equation  

NASA Astrophysics Data System (ADS)

The representation of stress-strain curves by empirical relations can give first-hand information on the deformation behavior of a material. Although the constants in these equations are simple numerals for smooth fitting of the curves, a theoretical basis using dislocation interaction has been out forth bv Berastrom.[1

Kishore, R.; Sinha, T. K.



Analysis of physical quality of soil using the water retention curve: Validity of the S-index  

Microsoft Academic Search

Among the various soil indicators established in order to discuss physical properties of soils is the S-index, derived from the slope of the soil water retention curve at its inflection point, used by a number of authors. In this publication we discuss the value of the slope at the inflection point of the soil water retention curve according to the

Glenio Guimarães Santos; Euzebio Medrado da Silva; Robélio Leandro Marchão; Pedro Marques da Silveira; Ary Bruand; Francois James; Thierry Becquer



Analysis of the stress-strain curves of a modified 9Cr1Mo steel by the voce equation  

Microsoft Academic Search

The representation of stress-strain curves by empirical relations can give first-hand information on the deformation behavior\\u000a of a material. Although the constants in these equations are simple numerals for smooth fitting of the curves, a theoretical\\u000a basis using dislocation interaction has been out forth bv Berastrom.[1

R. Kishore; T. K. Sinha



Latent curve analysis  

Microsoft Academic Search

As a method for representing development, latent trait theory is presented in terms of a statistical model containing individual parameters and a structure on both the first and second moments of the random variables reflecting growth. Maximum likelihood parameter estimates and associated asymptotic tests follow directly. These procedures may be viewed as an alternative to standard repeated measures ANOVA and

William Meredith; John Tisak



Comparison of age and sex regarding gingival and papillary recession.  


No studies have been published concerning the comparison between gingival and papillary recession in the maxillary esthetic zone (including incisors, canines, and premolars) regarding age and sex. This study addressed this issue. Adults (n = 250) with fully erupted permanent dentitions, healthy gingivae, and natural teeth in the maxillary esthetic area were included. Visual examinations were performed to detect papillary and gingival recession. Space evident apical to the contact area of adjacent teeth was recorded as papillary recession; a cementoenamel junction visible coronal to the buccal gingival margin was recorded as gingival recession. All sites with papillary and gingival recession were significantly associated with age; however, only some sites with gingival and papillary recession were associated with sex. Papillary recession was more severe than gingival recession in both extent and prevalence in subjects older than 30 years of age. Thus, papillary recession may be expected to be a more common esthetic dental problem. PMID:22754903

Chang, Li-Ching



Analysis of progress curves. Interaction of pyruvate kinase from Escherichia coli with fructose 1,6-bisphosphate and calcium ions.  

PubMed Central

The influence of fructose 1,6-bisphosphate and Ca2+ on the kinetics of pyruvate kinase from Escherichia coli K12 was studied (at pH 7.0 and 25 degrees C) by using the pH-stat method for the measurement of the reaction progress as well as initial-rate analysis. The data were analysed on the basis of a concerted model with three conformational states [Markus, Plesser, Boiteux, Hess & Malcovati (1980) Biochem. J. 189, 421-433] by using a novel procedure for a computer-directed treatment of progress curves [Markus & Plesser (1976) Biochem. Soc. Trans. 4, 361-364]. By addition of fructose 1,6-bisphosphate the sigmoid kinetics with respect to phosphoenolpyruvate and Mg2+ is abolished and the activity of the enzyme is described by classical saturation kinetics. This is explained by exclusive binding of fructose 1,6-bisphosphate at an allosteric site of the conformational state that forms the active complex. We observe that Ca2+ is an activator of the enzyme at low Mg2+ and Ca2+ concentrations; otherwise it is an inhibitor. These effects can be understood by assuming that Ca2+ has the same binding properties as Mg2+, although it does not allow a catalytic turnover.

Boiteux, A; Markus, M; Plesser, T; Hess, B; Malcovati, M



Rapid and cost effective detection of small mutations in the DMD gene by high resolution melting curve analysis.  


Duchenne/Becker muscular dystrophy (DMD/BMD) is caused by large deletions or duplications in two-thirds of the cases. The remaining one-third DMD patients have small mutations in the DMD gene. Screening for such small mutations is a daunting and costly task. High resolution melting curve analysis (HR-MCA) followed by sequencing for amplicons with altered melting profiles can be used to scan DNA for small alterations. We first validated the technique as screening procedure for the DMD gene and then screened a group of unrelated 22 DMD/BMD patients and 11 females. We managed to identify all previously found mutations by means of HR-MCA, which provided its validation. Furthermore, 17 different pathogenic mutations were found in the screening group, of which 10 were novel. Our results provide validation of HR-MCA as a powerful and inexpensive pre-sequencing scanning method. This technology is now ready for routine diagnostic use on DMD/BMD patients and female carriers. PMID:19409785

Almomani, Rowida; van der Stoep, Nienke; Bakker, Egbert; den Dunnen, Johan T; Breuning, Martijn H; Ginjaar, Ieke B



A Biometric Latent Curve Analysis of Memory Decline in Older Men of the NAS-NRC Twin Registry  

PubMed Central

Previous research has shown cognitive abilities to have different biometric patterns of age-changes. Here we examined the variation in episodic memory (Words Recalled) for over 6,000 twin pairs who were initially aged 59-75, and were subsequently re-assessed up to three more times over 12 years. In cross-sectional analyses, variation in Education was explained by strong additive genetic influences (~43%) together with shared family influences (~35%) that were independent of age. The longitudinal phenotypic analysis of the Word Recall task showed systematic linear declines over age, but with positive influences of Education and Retesting. The longitudinal biometric estimation yielded: (a) A separation of non-shared environmental influences and transient measurement error (~50%): (b) Strong additive genetic components of this latent curve (~70% at age 60) with increases over age that reach about 90% by age 90. (c) The minor influences of shared family environment (~17% at age 60) were effectively eliminated by age 75. (d) Non-shared environmental effects play an important role over most of the life-span (peak of 42% at age 70) but their relative role diminishes after age 75.

McArdle, John J.; Plassman, Brenda L.



The Recession of the Niagara Gorge  

Microsoft Academic Search

BEFORE the survey of 1842, the only data for estimating the rate of recession of the Niagara Gorge were the observations of the people of the neighbourhood. Mr. Bakewell, in 1829, ``was informed by Mr. Forsyth, the proprietor of the Pavilion Hotel on the Canada side, that during his residence of forty years the Falls had receded forty yards'' (American

Edward G. Bourne



Corporate energy staffs cut: managers blame recession  

SciTech Connect

Energy management staff and projects are both being reduced as some recession-squeezed companies minimize spending. The result is that some companies cannot meet their long-range conservation goals, and some are now consuming more energy. Employees hesitate to suggest conservation projects because of capital restraints even when their companies are prepared to accept new investment. (DCK)

Crawford, E.



What is a recession?: A reprise  

Microsoft Academic Search

This paper draws its title from a paper written over 35 years ago by Geoffrey H. Moore (1967). Why the need for a reprise? First, there would appear currently to be somewhat diverging views as to what properly constitutes a recession. Second, largely as a result of this, in many countries other than the US, there does not exist a

Allan P. Layton; Anirvan Banerji




Microsoft Academic Search

This paper draws its title from a paper written over 30 years ago by Geoffrey H. Moore (1967). Why the need for a reprise? First, there would appear currently to be somewhat diverging views – particularly in Australia – as to what properly constitutes a recession. Second, largely as a result of this, in Australia and many other countries other

Allan P. Layton; Anirvan Banerji



Gender Differences during Recess in Elementary Schools.  

ERIC Educational Resources Information Center

A study examined the differences in what boys and girls choose, or are free to choose, to do on the playground during recess. Given the apparent problem that boys dominate the playground area, leaving girls on the perimeter, it was hypothesized that girls engage in passive, non-competitive, small group activities, whereas boys engage in…

Twarek, Linda S.; George, Halley S.


Help! It's an Indoor Recess Day.  

ERIC Educational Resources Information Center

|This book provides a collection of easy-to-implement ideas and creative strategies designed to help teachers manage indoor recess by developing temporary playrooms. Chapter 1 helps teachers make a good assessment of the present situation. Chapter 2 encourages teachers to take heart, no matter how frustrated they may have been in the past, and…

Novak, Dori E.


Nevada, the Great Recession, and Education  

ERIC Educational Resources Information Center

|The impact of the Great Recession and its aftermath has been devastating in Nevada, especially for public education. This article discusses the budget shortfalls and the impact of the economic crisis in Nevada using case study methodology. It provides a review of documents, including Governor Gibbon's proposals for the public K-12 education…

Verstegen, Deborah A.



Recessive disorders - a serious health hazard?  

Microsoft Academic Search

Summary The aim of this study is to summarize new findings on the most important recessive hereditary disorders in cattle. Important diseases in cattle breeding are: BLAD (Bovine Leukocyte Adhesion Deficiency), DUMPS (Deficiency of Uridine - 5-Monophosphate Synthase), MSUD (Maple Syrup Urine Disease), Bovine Citrullinaemia, and - not detected until 2000 - CVM (Complex Vertebral Malformation). Some of these disorders

Barbora Bláhová


Eliminating the Federal Budget Deficit Without Recession  

Microsoft Academic Search

The federal government's budget deficit of more than $150 billion, some 3 to 4 percent of gross national product, is widely perceived as a serious problem. This article considers policy for wiping out the deficit without recession. Simulations of the Wharton econometric model show that a tax increase would have some slowing effect on the economy but would not cause

F. Gerard Adams



Detecting differential allelic expression using high-resolution melting curve analysis: application to the breast cancer susceptibility gene CHEK2  

PubMed Central

Background The gene CHEK2 encodes a checkpoint kinase playing a key role in the DNA damage pathway. Though CHEK2 has been identified as an intermediate breast cancer susceptibility gene, only a small proportion of high-risk families have been explained by genetic variants located in its coding region. Alteration in gene expression regulation provides a potential mechanism for generating disease susceptibility. The detection of differential allelic expression (DAE) represents a sensitive assay to direct the search for a functional sequence variant within the transcriptional regulatory elements of a candidate gene. We aimed to assess whether CHEK2 was subject to DAE in lymphoblastoid cell lines (LCLs) from high-risk breast cancer patients for whom no mutation in BRCA1 or BRCA2 had been identified. Methods We implemented an assay based on high-resolution melting (HRM) curve analysis and developed an analysis tool for DAE assessment. Results We observed allelic expression imbalance in 4 of the 41 LCLs examined. All four were carriers of the truncating mutation 1100delC. We confirmed previous findings that this mutation induces non-sense mediated mRNA decay. In our series, we ruled out the possibility of a functional sequence variant located in the promoter region or in a regulatory element of CHEK2 that would lead to DAE in the transcriptional regulatory milieu of freely proliferating LCLs. Conclusions Our results support that HRM is a sensitive and accurate method for DAE assessment. This approach would be of great interest for high-throughput mutation screening projects aiming to identify genes carrying functional regulatory polymorphisms.



A Latent Growth Curve Analysis of the Structure of Aggression, Drug Use, and Delinquent Behaviors and their Interrelations over Time in Urban and Rural Adolescents  

ERIC Educational Resources Information Center

|Latent growth curve analysis was used to examine the structure and interrelations among aggression, drug use, and delinquent behavior during early adolescence. Five waves of data were collected from 667 students at three urban middle schools serving a predominantly African American population, and from a more ethnically diverse sample of 950…

Farrell, Albert D.; Sullivan, Terri N.; Esposito, Layla E.; Meyer, Aleta L.; Valois, Robert F.



Usefulness of Three-Channel Multiplex Real-Time PCR and Melting Curve Analysis for Simultaneous Detection and Identification of the Mycobacterium tuberculosis Complex and Nontuberculous Mycobacteria ?  

PubMed Central

We attempted to determine the benefits of three-channel multiplex real-time PCR and melting curve analysis not only in detecting and distinguishing between nontuberculous mycobacteria (NTM) and the Mycobacterium tuberculosis complex but also in identifying NTM to the species level.

Hong, Yun Ji; Chung, Young Hoon; Kim, Taek Soo; Song, Sang Hoon; Park, Kyoung Un; Yim, Jae Joon; Song, Junghan; Lee, Jae Ho; Kim, Eui Chong



Measuring the elastic properties of living cells through the analysis of current-displacement curves in scanning ion conductance microscopy.  


Knowledge of mechanical properties of living cells is essential to understand their physiological and pathological conditions. To measure local cellular elasticity, scanning probe techniques have been increasingly employed. In particular, non-contact scanning ion conductance microscopy (SICM) has been used for this purpose; thanks to the application of a hydrostatic pressure via the SICM pipette. However, the measurement of sample deformations induced by weak pressures at a short distance has not yet been carried out. A direct quantification of the applied pressure has not been also achieved up to now. These two issues are highly relevant, especially when one addresses the investigation of thin cell regions. In this paper, we present an approach to solve these problems based on the use of a setup integrating SICM, atomic force microscopy, and optical microscopy. In particular, we describe how we can directly image the pipette aperture in situ. Additionally, we can measure the force induced by a constant hydrostatic pressure applied via the pipette over the entire probe-sample distance range from a remote point to contact. Then, we demonstrate that the sample deformation induced by an external pressure applied to the pipette can be indirectly and reliably evaluated from the analysis of the current-displacement curves. This method allows us to measure the linear relationship between indentation and applied pressure on uniformly deformable elastomers of known Young's modulus. Finally, we apply the method to murine fibroblasts and we show that it is sensitive to local and temporally induced variations of the cell surface elasticity. PMID:22744227

Pellegrino, Mario; Pellegrini, Monica; Orsini, Paolo; Tognoni, Elisabetta; Ascoli, Cesare; Baschieri, Paolo; Dinelli, Franco



Gingival recession associated with Orthodontic treatment and root coverage  

Microsoft Academic Search

Many patients seek to pursue orthodontic treatment for esthetic improvement. These patients present with mal- alignment of the anterior teeth. There was strong correlation between the severity and extent of gingival recessions and past orthodontic treatment, it was suggested that orthodontic tooth movement may lead to gingival recession. The principal objective in the treatment of gingival recession is to cover

Alparslan Dilsiz; Tugba Aydin



Analysis of the low part of stress-strain curves in rat skin. Influence of age and desmotropic drugs.  


Stress-strain behaviour of skin strips in rats at different ages or after treatment with prednisolone or D-penicillamine has been analyzed. Special attention has been paid to the lower part of the stress-strain curves. A "hump" at an extension degree of 30% of original length was noted. When rats of different ages were compared this phenomenon was observed predominantly at an age of 2 months. Futhermore, this hump was remarkable in rats treated with prednisolone. When the stress-strain curves of rats at different ages or after treatment were averaged and normalized, the most pronounced deviations were found at an age of 2 months or after prednisolone treatment. The maximum of deviation from Hooke's law occurred at a relative extension degree of 70%. Thus, the maturation process and the influence of corticosteroid affected mostly the second part of the stress-strain curve. In order to evaluate further the stress-strain curves 3 consecutive tangents of the stress-strain curves indicating modules of elasticity were evaluated. The first and second modules of elasticity showed a minimum at an age of 2 months, whereas the ultimate elasticity modules increased with maturation up to a maximum at 12 months followed by a decrease similar to that observed in tensile strength at an age of 24 months. PMID:869577

Vogel, H G; Hilgner, W



Analysis of switching properties of porous ferroelectric ceramics by means of first-order reversal curve diagrams  

NASA Astrophysics Data System (ADS)

Particular aspects of the switching properties of the Nb-PZT ceramics with anisotropic porosity (40% relative porosity) were investigated by comparison with the dense ceramics (5% relative porosity) of the same composition by means of the first-order reversal curve (FORC) analysis. The reversible/irreversible components give different contributions to the total polarization: A sharp FORC distribution with an almost negligible reversible component is characteristic to the dense material, while a broad distribution with an important reversible component is characteristic for the porous one. The coercivity corresponding to the maximum of the irreversible component is the same irrespective to the sample density and pore’s configuration with respect to the electrodes: Ec,M=1.5kV/mm , while the bias fields are zero for the dense ceramic, small and positive; Ebias,M=50V/mm , when the major axis of the elongated pores is parallel with the electrodes and negative; Ebias,M=-100V/mm , when this axis is perpendicular to the electrodes. The influence of the dipolar coupling leading to such bias fields is explained by considering that the particular microstructure is causing a symmetry breaking, decoupling the dipolar interaction (forward or laterally). A dipolar (discrete) model with random orientations of the dipoles’ directions was used to simulate this confinement effect. The calculated FORC diagrams lead to the same type of bias as the experimental ones, proving that the lateral confinement gives an intrinsic contribution to the biased P(E) loops observed for the porous ceramics. In addition with other possible extrinsic contributions, this dipolar coupling can be a source of the built-in field in confined ferroelectric structures. The experimental FORC distribution was used as input in a Preisach-type model to recompose the major and symmetric minor hysteresis loops and a remarkable agreement with the experimental data was obtained. The FORC method proves to be an excellent tool in describing the ferroelectric systems, simulating polarization experiments, and predicting outputs of the circuits with ferroelectric capacitors. In the particular case of the porous anisotropic ceramics, the combined experimental and analytical FORC analysis allowed us to probe and to describe qualitatively the presence of the bias field as a result of the geometrical confinement.

Stoleriu, Laurentiu; Stancu, Alexandru; Mitoseriu, Liliana; Piazza, Daniele; Galassi, Carmen



Autosomal recessive nonsyndromic deafness genes: a review  

PubMed Central

More than 50 percent of prelingual hearing loss is genetic in origin, and of these up to 93 percent are monogenic autosomal recessive traits. Some forms of genetic deafness can be recognized by their associated syndromic features, but in most cases, hearing loss is the only finding and is referred to as nonsyndromic deafness. To date, more than 700 different mutations have been identified in one of 42 genes in individuals with autosomal recessive nonsyndromic hearing loss (ARNSHL). Reported mutations in GJB2, encoding connexin 26, makes this gene the most common cause of hearing loss in many populations. Other relatively common deafness genes include SLC26A4, MYO15A, OTOF, TMC1, CDH23, and TMPRSS3. In this report we summarize genes and mutations reported in families with ARNSHL. Founder effects were demonstrated for some recurrent mutations but the most significant findings are the extreme locus and allelic heterogeneity and different spectrum of genes and mutations in each population.

Duman, Duygu; Tekin, Mustafa



Analysis of the stress-strain curves of a modified 9Cr-1Mo steel by the Voce equation  

SciTech Connect

The representation of stress-strain curves by empirical relations can give first-hand information on the deformation behavior of a material. Although the constants in these equations are simple numerals for smooth fitting of the curves, a theoretical basis using dislocation interaction has been put forth by Bergstrom. In summary, the following points can be made. (1) The Voce equation was found to fit the stress-strain curves of the modified 9Cr-1Mo steel under various heat treatments quite satisfactorily. (2) The magnitude of work hardening, its rate of rise or fall with strain, systematically affects the empirical constants, and it appears that these constants manifest the dislocation activities in the material during deformation.

Kishore, R.; Sinha, T.K. [BARC, Bombay (India). Metallurgy Div.



Synthetic light-curve analysis of the very short period binaries TY Bootis, AD Cancri, and V523 Cassiopeiae  

SciTech Connect

New photometric observations of TY Boo, AD Cnc, and V523 Cas are subjected to synthetic light-curve analyses using the Wilson-Devinney code. Solutions for each of the systems, and the several competing theories of contact binary structure are discussed in light of the results. Both AD Cnc and V523 Cas are modeled with subluminous regions, and the resulting starspot parameters are reported. A simultaneous solution of the B, V light curves and the radial-velocity curves of V523 Cas is presented. Spectroscopic and photometric mass ratios were found to be discordant for both TY Boo and V523 Cas. However, recent spectroscopic work by Groissman seems to remove the discordancy for TY Boo. Absolute parameters are derived for V523 Cas. 43 refs.

Samec, R.G.; Van Hamme, W.; Bookmyer, B.B. (Butler Univ., Indianapolis, IN (USA) Clemson Univ., SC (USA) South Carolina Univ., Conway (USA) Florida International Univ., Miami (USA))



The eclipsing binary star V380 Gem: First V and Rc light curve analysis and estimation of its absolute elements  

NASA Astrophysics Data System (ADS)

We obtained complete V and Rc light curves of the eclipsing binary V380 Gem in 2012. With our data we were able to determine six new times of minimum light and refine the orbital period of the system to 0.3366088 days. The 2003 version of the Wilson–Devinney code was used to analyze the light curves in the V and Rc bands simultaneously. It is shown that V380 Gem may be classified as an W-type W Ursae Majoris system with a high mass ratio q = 1.45, a degree of contact f = 10.6% the same temperature for both the components (?T = 10 K) and an orbital inclination of i = 81.5°. Our observations show symmetric light curves in all passbands with brightness in both maxima at the same level. The absolute dimensions of V380 Gem are estimated and its dynamical evolution is inferred.

Barani, C.; Martignoni, M.; Acerbi, F.



Does orthodontic treatment lead to gingival recession?  

Microsoft Academic Search

Data sourcesMedline, Embase, The Cochrane Central Register of Controlled Trials (CENTRAL) and the reference lists of identified studies.Study selectionHuman controlled or randomised clinical trials and animal studies reporting occurrence of gingival recession and crown length changes were included. Case reports, descriptive studies, review articles, opinion articles and studies concerning impacted teeth or injured anterior teeth, pre-orthodontic treatment for dental restoration

Carlos Flores-Mir



Pole tip recession in linear recording heads  

Microsoft Academic Search

Using a range of experimental techniques-optical and atomic force microscopy, and Auger electron spectroscopy-we have identified the major processes responsible for pole tip recession (PTR) in linear tape recording systems. Within a few tens of hours, TiC grain fragments pulled out from the tape-bearing surface ceramic (Al2O3-TiC) are trapped in the pole tip region and, hence, act as three-body abrasive

E. Sourty; J. L. Sullivan; L. A. M. De Jong



Autosomal recessive cutis laxa syndrome revisited  

PubMed Central

The clinical spectrum of the autosomal recessive cutis laxa syndromes is highly heterogeneous with respect to organ involvement and severity. One of the major diagnostic criteria is to detect abnormal elastin fibers. In several other clinically similar autosomal recessive syndromes, however, the classic histological anomalies are absent, and the definite diagnosis remains uncertain. In cutis laxa patients mutations have been demonstrated in elastin or fibulin genes, but in the majority of patients the underlying genetic etiology remains unknown. Recently, we found mutations in the ATP6V0A2 gene in families with autosomal recessive cutis laxa. This genetic defect is associated with abnormal glycosylation leading to a distinct combined disorder of the biosynthesis of N- and O-linked glycans. Interestingly, similar mutations have been found in patients with wrinkly skin syndrome, without the presence of severe skin symptoms of elastin deficiency. These findings suggest that the cutis laxa and wrinkly skin syndromes are phenotypic variants of the same disorder. Interestingly many phenotypically similar patients carry no mutations in the ATP6V0A2 gene. The variable presence of protein glycosylation abnormalities in the diverse clinical forms of the wrinkled skin-cutis laxa syndrome spectrum necessitates revisiting the diagnostic criteria to be able to offer adequate prognosis assessment and counseling. This paper aims at describing the spectrum of clinical features of the various forms of autosomal recessive cutis laxa syndromes. Based on the recently unraveled novel genetic entity we also review the genetic aspects in cutis laxa syndromes including genotype–phenotype correlations and suggest a practical diagnostic approach.

Morava, Eva; Guillard, Mailys; Lefeber, Dirk J; Wevers, Ron A



Recovering From Recession - With Far Less Pain  

NSDL National Science Digital Library

Thirty-seventh monthly installment of our "What A Year!" website project, introducing life science breakthroughs to middle and high school students and their teachers. Gum recession is both aesthetically unpleasant and medically risky. At risk are the patient's teeth and oral health. But the traditional treatment has been painful and not completely satisfactory. Now there is a new treatment that works better and reduces pain and discomfort.



Analysis of Tipping-Curve Measurements Performed at the DSS-13 Beam-Waveguide Antenna at 32 and 8.45 Gigahertz  

NASA Astrophysics Data System (ADS)

This article reports on the analysis of the Ka-band Antenna Performance Experiment tipping-curve data acquired at the DSS-13 research and development beamwaveguide (BWG) antenna. By measuring the operating system temperatures as the antenna is moved from zenith to low-elevation angles and fitting a model to the data, one can obtain information on how well the overall temperature model behaves at zenith and approximate the contribution due to the atmosphere. The atmospheric contribution estimated from the data can be expressed in the form of (1) atmospheric noise temperatures that can provide weather statistic information and be compared against those estimated from other methods and (2) the atmospheric loss factor used to refer efficiency measurements to zero atmosphere. This article reports on an analysis performed on a set of 68 8.4-GHz and 67 32-GHz tipping-curve data sets acquired between December 1993 and May 1995 and compares the results with those inferred from a surface model using input meteorological data and from water vapor radiometer (WVR) data. The general results are that, for a selected subset of tip curves, (1) the BWG tipping-curve atmospheric temperatures are in good agreement with those determined from WVR data (the average difference is 0.06 ± 0.64 K at 32 GHz) and (2) the surface model average values are biased 3.6 K below those of the BWG and WVR at 32 GHz.

Morabito, D. D.; Skjerve, L.



Analysis of tipping-curve measurements performed at the DSS-13 beam-waveguide antenna at 32.0 and 8.45 GigaHertz  

NASA Astrophysics Data System (ADS)

This article reports on the analysis of the Ka-band Antenna Performance Experiment tipping-curve data acquired at the DSS-13 research and development beam-waveguide (BWG) antenna. By measuring the operating system temperatures as the antenna is moved form zenith to low-elevation angles and fitting a model to the data, one can obtain information on how well the overall temperature model behaves at zenith and approximate the contribution due to the atmosphere. The atmospheric contribution estimated from the data can be expressed in the form of (1) atmospheric noise temperatures that can provide weather statistic information and be compared against those estimated from other methods and (2) the atmospheric loss factor used to refer efficiency measurements to zero atmosphere. This article reports on an analysis performed on a set of 68 8.4-GHz and 67 32-GHz tipping-curve data sets acquired between December 1993 and May 1995 and compares the results with those inferred from a surface model using input meteorological data and from water vapor radiometer (WVR) data. The general results are that, for a selected subset of tip curves, (1) the BWG tipping-curve atmospheric temperatures are in good agreement with those determined from WVR data (the average difference is 0.06 +/- 0.64 K at 32 GHz) and (2) the surface model average values are biased 3.6 K below those of the BWG and WVR at 32 GHz.

Morabito, D. D.; Skjerve, L.



Light-curve analysis of KIC 12557548b: an extrasolar planet with a comet-like tail  

NASA Astrophysics Data System (ADS)

Context. An object with a very peculiar light curve was recently discovered using Kepler data. When this object was discovered, it was suggested that this object may be a transiting disintegrating extrasolar planet with a comet-like dusty tail. Aims: We aim to verify this model by modelling the light curve and put constraints on the geometry of the dust region and various dust properties. Methods: We modified the code SHELLSPEC, which is designed for modelling interacting binary stars to calculate the light curves of such planets. Mie absorption and scattering on spherical dust grains with realistic dust opacities, phase functions, and a finite radius of the source of the scattered light are taken into account Results: The light curve is reanalysed using long- and short-cadence Kepler observations from the first 14 quarters. The orbital period of the planet was improved. We prove that the peculiar light curve agrees with the idea of a planet with a comet-like tail. The light curve has a prominent pre-transit brightening and a less prominent post-transit brightening. Both are caused by the forward scattering and are a strong function of the particle size. This feature enabled us to estimate a typical particle size (radius) in the dust tail of about 0.1-1 micron. However, there is an indication that the particle size changes (decreases) along the tail. The dust density in the tail is a steep decreasing function of the distance from the planet, which indicates a significant tail destruction caused by the star-planet interaction. Several possible combinations of other dust properties are tabulated. We reveal interesting periodic long-term evolution of the tail on a time scale of about 1.3 years and also argue that the "planet" does not show a uniform behaviour, but may have at least two constituents. This exoplanet's tail evolution may find an analogy in the comet tail disconnection events caused by the magnetic/coronal activity of the Sun while the light curve with pre-transit brightening is analogous to the light curve of ? Aur and AZ Cas with mid-eclipse brightening and forward scattering playing a significant role in such eclipsing systems.

Budaj, J.



Discrimination of Closely-Spaced Geosynchronous Satellites - Phase Curve Analysis & New Small Business Innovative Research (SBIR) Efforts  

NASA Astrophysics Data System (ADS)

Geosynchronous objects appear as unresolved blurs even when observed with the largest ground-based telescopes. Due to the lack of any spatial detail, two or more objects appearing at similar brightness levels within the spectral bandpass they are observed are difficult to distinguish. Observing a changing pattern of such objects from one time epoch to another showcases the deficiencies in associating individual objects before and after the configuration change. This paper explores solutions to this deficiency in the form of spectral (under small business innovative research) and phase curve analyses. The extension of the technique to phase curves proves to be a powerful new capability.

Levan, P.



A regret theory approach to decision curve analysis: A novel method for eliciting decision makers' preferences and decision-making  

PubMed Central

Background Decision curve analysis (DCA) has been proposed as an alternative method for evaluation of diagnostic tests, prediction models, and molecular markers. However, DCA is based on expected utility theory, which has been routinely violated by decision makers. Decision-making is governed by intuition (system 1), and analytical, deliberative process (system 2), thus, rational decision-making should reflect both formal principles of rationality and intuition about good decisions. We use the cognitive emotion of regret to serve as a link between systems 1 and 2 and to reformulate DCA. Methods First, we analysed a classic decision tree describing three decision alternatives: treat, do not treat, and treat or no treat based on a predictive model. We then computed the expected regret for each of these alternatives as the difference between the utility of the action taken and the utility of the action that, in retrospect, should have been taken. For any pair of strategies, we measure the difference in net expected regret. Finally, we employ the concept of acceptable regret to identify the circumstances under which a potentially wrong strategy is tolerable to a decision-maker. Results We developed a novel dual visual analog scale to describe the relationship between regret associated with "omissions" (e.g. failure to treat) vs. "commissions" (e.g. treating unnecessary) and decision maker's preferences as expressed in terms of threshold probability. We then proved that the Net Expected Regret Difference, first presented in this paper, is equivalent to net benefits as described in the original DCA. Based on the concept of acceptable regret we identified the circumstances under which a decision maker tolerates a potentially wrong decision and expressed it in terms of probability of disease. Conclusions We present a novel method for eliciting decision maker's preferences and an alternative derivation of DCA based on regret theory. Our approach may be intuitively more appealing to a decision-maker, particularly in those clinical situations when the best management option is the one associated with the least amount of regret (e.g. diagnosis and treatment of advanced cancer, etc).



The Environmental Kuznets Curve and Convergence of Sulfur Emissions in OECD Countries : Analysis Based on the Green Solow Model  

Microsoft Academic Search

This paper investigates the relationship between economic growth and the environment based on the Green Solow model. We observed the resemblance of the shapes of the environmental Kuznets curve between per capita GDP and sulfur emissions for 17 OECD countries. Using cross-national panel data, the convergence of sulfur emissions per capita for 25 OECD countries was analyzed. Overall, a conditional

Shingo OHKUMA; Hideo NODA



Functional torque ratios and torque curve analysis of shoulder rotations in overhead athletes with and without impingement symptoms  

Microsoft Academic Search

In this study, we evaluated the peak torque, functional torque ratios, and torque curve profile of the shoulder rotators in overhead athletes with impingement symptoms so as to examine possible alterations in response to sports training and shoulder pain. Twenty-one overhead athletes with impingement symptoms were compared with 25 overhead athletes and 21 non-athletes, none of whom were symptomatic for

Gisele G. Zanca; Ana B. Oliveira; Michele F. Saccol; Benno Ejnisman; Stela M. Mattiello-Rosa



Analysis of paradoxes arising from the Chezy formula with constant roughness: II. Flow area-discharge curve  

Microsoft Academic Search

The Chezy formula for steady flow in a uniform symmetrical channel with constant slope-friction factor is mathematically examined. The problem of the determination of the channel shape above a reference level for a given rating curve of flow area vs discharge with a constant ratio (m) of slope to mean velocity above a reference level is posed and then solved.



Analysis of paradoxes arising from the Chezy formula with constant roughness: II. Flow area-discharge curve  

Microsoft Academic Search

The Chezy formula for steady flow in a uniform symmetrical channel with constant slope-friction factor is mathematically examined. The problem of the determination of the channel shape above a reference level for a given rating curve of flow area vs discharge with a constant ratio (m) of slope to mean velocity above a reference level is posed and then solved.




Bayesian Analysis of Item Response Curves. Research Report 84-1. Mathematical Sciences Technical Report No. 132.  

ERIC Educational Resources Information Center

Item response curves for a set of binary responses are studied from a Bayesian viewpoint of estimating the item parameters. For the two-parameter logistic model with normally distributed ability, restricted bivariate beta priors are used to illustrate the computation of the posterior mode via the EM algorithm. The procedure is illustrated by data…

Tsutakawa, Robert K.; Lin, Hsin Ying


Computational Analysis of Flow in a Curved Tube Model of the Coronary Arteries: Effects of Time-varying Curvature  

Microsoft Academic Search

The flow through a curved tube whose radius of curvature varies with time was studied in order to better understand flow patterns in coronary arteries. A computational flow model was constructed using commercially available software. The artery model featured a uniform circular cross section, and the curvature was assumed to be constant along the tube, and in one plane. The

Aland Santamarina; Erlend Weydahl



Differential School Effects among Low, Middle, and High Social Class Composition Schools: A Multiple Group, Multilevel Latent Growth Curve Analysis  

ERIC Educational Resources Information Center

|This study uses large-scale survey data and a multiple group, multilevel latent growth curve model to examine differential school effects between low, middle, and high social class composition public schools. The results show that the effects of school inputs and school practices on learning differ across the 3 subpopulations. Moreover, student…

Palardy, Gregory J.



A Statistical Comparison of the Blossom Blight Forecasts of MARYBLYT and Cougarblight with Receiver Operating Characteristic Curve Analysis  

Technology Transfer Automated Retrieval System (TEKTRAN)

Blossom blight forecasting is an important aspect of fire blight, caused by Erwinia amylovora, management for both apple and pear. A comparison of the forecast accuracy of two common fire blight forecasters, MARYBLYT and Cougarblight, was performed with receiver operating characteristic (ROC) curve ...


A Recessive Gene for Primary Vesicoureteral Reflux Maps to Chromosome 12p11-q13  

PubMed Central

Primary vesicoureteral reflux (pVUR) is one of the most common causes of pediatric kidney failure. Linkage scans suggest that pVUR is genetically heterogeneous with two loci on chromosomes 1p13 and 2q37 under autosomal dominant inheritance. Absence of pVUR in parents of affected individuals raises the possibility of a recessive contribution to pVUR. We performed a genome-wide linkage scan in 12 large families segregating pVUR, comprising 72 affected individuals. To avoid potential misspecification of the trait locus, we performed a parametric linkage analysis using both dominant and recessive models. Analysis under the dominant model yielded no signals across the entire genome. In contrast, we identified a unique linkage peak under the recessive model on chromosome 12p11-q13 (D12S1048), which we confirmed by fine mapping. This interval achieved a peak heterogeneity LOD score of 3.6 with 60% of families linked. This heterogeneity LOD score improved to 4.5 with exclusion of two high-density pedigrees that failed to link across the entire genome. The linkage signal on chromosome 12p11-q13 originated from pedigrees of varying ethnicity, suggesting that recessive inheritance of a high frequency risk allele occurs in pVUR kindreds from many different populations. In conclusion, this study identifies a major new locus for pVUR and suggests that in addition to genetic heterogeneity, recessive contributions should be considered in all pVUR genome scans.

Weng, Patricia L.; Sanna-Cherchi, Simone; Hensle, Terry; Shapiro, Ellen; Werzberger, Alan; Caridi, Gianluca; Izzi, Claudia; Konka, Anita; Reese, Adam C.; Cheng, Rong; Werzberger, Samuel; Schlussel, Richard N.; Burk, Robert D.; Lee, Joseph H.; Ravazzolo, Roberto; Scolari, Francesco; Ghiggeri, Gian Marco; Glassberg, Kenneth; Gharavi, Ali G.



The Carnegie Curve  

NASA Astrophysics Data System (ADS)

The Earth's fair weather atmospheric electric field shows, in clean air, an average daily variation which follows universal time, globally independent of the measurement position. This single diurnal cycle variation (maximum around 19UT and minimum around 03UT) is widely known as the Carnegie curve, after the geophysical survey vessel of the Carnegie Institution of Washington on which the original measurement campaigns demonstrating the universal time variation were undertaken. The Carnegie curve's enduring importance is in providing a reference variation against which atmospheric electricity measurements are still compared; it is believed to originate from regular daily variations in atmospheric electrification associated with the different global disturbed weather regions. Details of the instrumentation, measurement principles and data obtained on the Carnegie's seventh and final cruise are reviewed here, also deriving new harmonic coefficients allowing calculation of the Carnegie curve for different seasons. The additional harmonic analysis now identifies changes in the phasing of the maximum and minimum in the Carnegie curve, which shows a systematic seasonal variation, linked to the solstices and equinoxes, respectively.

Harrison, R. Giles



A new classification system for gingival and palatal recession.  


Various classifications have been proposed to classify gingival recession. Miller's classification of gingival recession is most widely followed. With a wide array of cases in daily clinical practice, it is often difficult to classify numerous gingival recession cases according to defined criteria of the present classification systems. To propose a new classification system that gives a comprehensive depiction of recession defect that can be used to include cases that cannot be classified according to present classifications. A separate classification system for palatal recessions (PR) is also proposed. This article outlines the limitations of present classification systems and also the inability to classify PR. A new comprehensive classification system is proposed to classify recession on the basis of the position of interdental papilla and buccal/lingual/palatal recessions. PMID:23869122

Kumar, Ashish; Masamatti, Sujata Surendra



A new classification system for gingival and palatal recession  

PubMed Central

Various classifications have been proposed to classify gingival recession. Miller's classification of gingival recession is most widely followed. With a wide array of cases in daily clinical practice, it is often difficult to classify numerous gingival recession cases according to defined criteria of the present classification systems. To propose a new classification system that gives a comprehensive depiction of recession defect that can be used to include cases that cannot be classified according to present classifications. A separate classification system for palatal recessions (PR) is also proposed. This article outlines the limitations of present classification systems and also the inability to classify PR. A new comprehensive classification system is proposed to classify recession on the basis of the position of interdental papilla and buccal/lingual/palatal recessions.

Kumar, Ashish; Masamatti, Sujata Surendra



Evaluation of a new rapid molecular diagnostic system for Plasmodium falciparum combined with DNA filter paper, loop-mediated isothermal amplification, and melting curve analysis.  


Falciparum malaria is a fatal infection without immediate diagnosability or treatment. There are shortages of clinicians and examiners skilled in the treatment of malaria in non-endemic countries, including Japan. This study was performed to evaluate a novel rapid molecular diagnostic system consisting of loop-mediated isothermal amplification (LAMP) combined with DNA filter paper (FTA card) and melting curve analysis. Combining LAMP with melting curve analysis enabled diagnosis of Plasmodium falciparum more accurately with relative ease. FTA cards could be used to clarify problems regarding storage, infectivity, and transportation. The LAMP assay was carried out at a constant temperature of 63 degrees C for 90 min. The diagnostic system (malaria-LAMP) accurately diagnosed malaria (47 samples from Thailand and 50 from Zimbabwe) with 97.8% sensitivity and 85.7% specificity as compared with microscopic methods, indicating the usefulness of this combined system. PMID:19168954

Yamamura, Mariko; Makimura, Koichi; Ota, Yasuo



Restoration of the Spring Snowmelt Recession Below Dams for Native Species Protection in a Changing Climate  

NASA Astrophysics Data System (ADS)

Within Mediterranean-montane ecosystems, the spring snowmelt recession is a distinct feature of the natural annual hydrograph, providing an ecologically significant bridge between the physical disturbance of winter high flows and the biologically stressful conditions of summer low flows. In regulated systems, the snowmelt recession is often absent as the predictable flows are captured behind dams. While restoration of the spring recession is an identified ecological goal, methods for determining suitable ramping rates to transition from high to low flows are lacking, and the hydropower-related cost of such environmental flows under changing climate conditions is uncertain. Here we summarize a quantitative analysis of the spring recession for selected unregulated locations in the Sierra Nevada, California, USA, using an exponential-based function to describe the rate of change in discharge. Results indicate unimpaired recession rates in the Sierra Nevada are consistent across watersheds. We then apply a modeled recession based on these characteristics to an assessment of suitable instream habitat for a native river-breeding amphibian of concern and find that recession rates can be quantitatively modeled to provide ramping rate conditions suitable for native species. Finally, we evaluate the hydropower-related costs of imposing a springtime weekly ramping rate constraint in a regulated Sierran system under various climate warming scenarios. Results show that generation and revenue costs from a ramping rate constraint are low compared to costs associated with increased minimum instream flows throughout the summer, though with climate warming these hydropower costs become more pronounced. Results from these studies collectively provide resource managers with improved knowledge of river dynamics and help guide the prescription of flow regimes in managed river systems to better sustain aquatic and riparian ecosystems in changing hydroclimatic conditions.

Yarnell, S.; Epke, G.; Rheinheimer, D. E.; Viers, J. H.



Interest and satisfaction of dentists in practicing periodontics: A survey based on treatment of gingival recession  

PubMed Central

Background: Gingival recession is a common occurrence and patients often report to dental clinic with associated problems such as root surface hypersensitivity, esthetic concerns, cervical root abrasions, and root caries that make it a concern for patients. Based upon the fact that gingival recession is an enigma for clinicians because of multitude of etiological factors and plethora of treatment modalities present for its treatment, a survey was conducted to assess knowledge as well as opinion about most common etiology, classification, and preferred treatment of gingival recession and to evaluate the interest and satisfaction of dentists in practicing periodontics. Materials and Methods: Study design consisted of a cross-sectional online survey, conducted among dentists practicing in state of Punjab, India, in the month of April 2011. A structured online questionnaire consisting of 17 questions evaluating the interest of dentists in periodontics based on knowledge about gingival recession (most of them giving the possibility of multiple choices of answers) was sent to about 300 dentists. Pearson Chi-Square and Mann-Whitney U tests were used for statistical analysis of data collected. P ? 0.05 was considered as statistically significant and P ? 0.01 considered as highly significant. Results: A greater proportion of periodontists had better knowledge about etiology (P = 0.07), classification (P = 0.000), and treatment of gingival recession (P = 0.000). A greater number of periodontists opted for the surgical modalities to correct the defects produced by gingival recession as compared to non-periodontists and had better interest (P = 0.000) and satisfaction (P = 0.000) in practicing periodontics. Conclusion: The results elucidated that periodontists had better interest and satisfaction in practicing periodontics, and were more inclined towards surgical correction of gingival recession as compared to non-periodontists.

Grover, Vishakha; Kapoor, Anoop; Malhotra, Ranjan; Sachdeva, Sonia



Mutations of the tyrosinase gene produce autosomal recessive ocular albinism  

SciTech Connect

Albinism has historically been divided into ocular (OA) and oculocutaneous (OCA) types based on the presence or absence of clinically apparent skin and hair involvement in an individual with the ocular features of albinism. The major genes for OCA include the tyrosinase gene in OCA1 and the P gene in OCA2. X-linked and autosomal recessive OA have been described and the responsible genes have not been identified. We now present six Caucasian individuals who have the phenotype of autosomal recessive OA but who have OCA1 as shown by the presence of mutations of the tyrosinase. They had white or very light hair and white skin at birth, and cutaneous pigment developed in the first decade of life. At ages ranging from 1.5-23 years, hair color was dark blond to light brown. The skin had generalized pigment and well developed tan was present on the exposed arm and face skin of four. Iris pigment was present and iris translucency varied. Molecular analysis of the tyrosinase gene, using PCR amplification and direct di-deoxy sequencing showed the following mutations: E398Z/E398Q, P406S/g346a, R402E/T373K, ?/D383N, and H211N/T373K. The homozygous individual was not from a known consanguineous mating. T373K is the most common tyrosinase gene mutation in our laboratory. Three of these mutations are associated with a total loss of tyrosinase activity (g346a splice-site, T373K, and D383N), while four are associated with residual enzyme activity (H211N, R402E, E398Q, and P406S). These studies show that mutations of the tyrosinase gene can produce the phenotype of autosomal recessive OA in an individual who has normal amounts of cutaneous pigment and the ability to tan after birth. This extends the phenotypic range of OCA1 to normal cutaneous pigment after early childhood, and suggest that mutations of the tyrosinase gene account for a significant number of individuals with autosomal recessive OA.

King, R.A.; Summers, C.G.; Oetting, W.S. [Univ. of Minnesota, Minneapolis, MN (United States)] [and others



Population based growth curve analysis: a comparison between models based on ordinary or stochastic differential equations implemented in a nonlinear mixed effect framework  

Microsoft Academic Search

\\u000a Growth curve analysis is frequently carried out in the study of growth of farm animals because measurements are taken repeatedly\\u000a over time on the same individual within groups of animals. Growth functions like the Gompertz, Richards and Lopez, which are\\u000a based on ordinary differential equations (ODE), can be used to model the functional relationship between size or mass and\\u000a age.

A. B. Strathe; A. Danfœr; B. Nielsen; S. Klim; H. Sørensen


Standard Mastery Curves and Skew Curves.  

ERIC Educational Resources Information Center

The objective of the study is to convince educational researchers of the necessity for "standard mastery curves" for the graphical representation of scores on summative tests for a group of students. Attention is drawn to the study of theoretical and empirical skew curves in education and biology. Use of standard mastery curves and study of skew…

Warries, Egbert



Microsoft Academic Search

The freezing point curve for the system uranium hexafluoride--hydrogen ; fluoride was determined over the range 0.0 to 0.6 wt% hydrogen fluoride and is ; represented by the equation wt% HF = 0.0841 DELTA t + 0.1020 DELTA t² -- ; 0.1046 DELTA t³ + 0.0363 DELTA t⁴ where DELTA t is the depression ; of the freezing point of

R. J. Wertz; W. D. Hedge



Television Viewing and Adolescents’ Judgment of Sexual Request Scripts: A Latent Growth Curve Analysis in Early and Middle Adolescence  

Microsoft Academic Search

A longitudinal study was conducted to explore the relationship between television viewing and beliefs about expressing sexual\\u000a desire in dating situations. In three consecutive years, a panel of early adolescents (N?=?883) and a panel of middle adolescents (N?=?651) rated the effectiveness of a sexual approach and a romantic approach. Latent growth curve analyses indicate that between\\u000a the ages of 12

Steven Eggermont



Human Capital, Social Support, and Economic Well-being among Rural, Low-income Mothers: A Latent Growth Curve Analysis  

Microsoft Academic Search

The purpose of this study was to better understand human capital and social support in the long-term economic well-being of\\u000a rural, low-income mothers in the US. Three waves of data from a multi-state, longitudinal investigation tracking the well-being\\u000a of rural families, known as “Rural Families Speak,” were used to test two latent growth curve models of economic well-being.\\u000a Results indicated

Leigh Ann Simmons; Bonnie Braun; David W. Wright; Scott R. Miller



Mutations Induced in Tradescantia by Small Doses of X-rays and Neutrons: Analysis of Dose-Response Curves  

Microsoft Academic Search

Dose-response curves for pink somatic mutations in Tradescantia stamen hairs were analyzed after neutron and x-ray irradiation with doses ranging from a fraction of a rad to the region of saturation. The dose-effect relation for neutrons indicates a linear dependence from 0.01 to 8 rads; between 0.25 and 5 rads a linear dependence is indicated for x-rays also. As a

A. H. Sparrow; A. G. Underbrink; H. H. Rossi



Analysis of the long-term behavior of solute transport with nonlinear equilibrium sorption using breakthrough curves and temporal moments  

Microsoft Academic Search

We analyzed the long-term behavior of breakthrough curves (BTCs) and temporal moments of a solute subjected to Freundlich equilibrium sorption (s=kcn). For one-dimensional transport in a homogeneous porous medium, we derived a power-law relation between travel time, ?, and solute displacement, x?, with the exponent being equal to the Freundlich n exponent. The mean solute velocity, derived from the first

H. Vereecken; U Jaekel; H Schwarze



Evaluation of dose-response curve analysis in delineating shared or different molecular sites of action for osteolathyrogens  

Microsoft Academic Search

Single-chemical and mixture concentration-response curves generated using a frog embryo model were examined for value in assessing whether chemicals exert toxic effects at the same or at different molecular sites of action. Toxicity tests were conducted on a series of osteolathyrogens, i.e. chemicals that inhibit cross-linking of developing connective tissue fibers. Induction of osteolathyrism, which manifests as lesions in the

Douglas A. Dawson; Brenda D. Scott; M. Jason Ellenberger; Gerald Pöch; Andrea C. Rinaldi



Efficacy of atomoxetine in adult attention-Deficit\\/Hyperactivity Disorder: a drug-placebo response curve analysis  

Microsoft Academic Search

BACKGROUND: The objective of this study was to evaluate the efficacy of atomoxetine, a new and highly selective inhibitor of the norepinephrine transporter, in reducing symptoms of attention-deficit\\/hyperactivity disorder (ADHD) among adults by using drug-placebo response curve methods. METHODS: We analyzed data from two double-blind, placebo-controlled, parallel design studies of adult patients (Study I, N = 280; Study II, N

Stephen V Faraone; Joseph Biederman; Thomas Spencer; David Michelson; Lenard Adler; Fred Reimherr; Stephen J Glatt



Smearing technique for vibration analysis of simply supported cross-stiffened and doubly curved thin rectangular shells.  


Plates stiffened with ribs can be modeled as equivalent homogeneous isotropic or orthotropic plates. Modeling such an equivalent smeared plate numerically, say, with the finite element method requires far less computer resources than modeling the complete stiffened plate. This may be important when a number of stiffened plates are combined in a complicated assembly composed of many plate panels. However, whereas the equivalent smeared plate technique is well established and recently improved for flat panels, there is no similar established technique for doubly curved stiffened shells. In this paper the improved smeared plate technique is combined with the equation of motion for a doubly curved thin rectangular shell, and a solution is offered for using the smearing technique for stiffened shell structures. The developed prediction technique is validated by comparing natural frequencies and mode shapes as well as forced responses from simulations based on the smeared theory with results from experiments with a doubly curved cross-stiffened shell. Moreover, natural frequencies of cross-stiffened panels determined by finite element simulations that include the exact cross-sectional geometries of panels with cross-stiffeners are compared with predictions based on the smeared theory for a range of different panel curvatures. Good agreement is found. PMID:21361430

Luan, Yu; Ohlrich, Mogens; Jacobsen, Finn



CFLs in Recessed Downlights: Technical Challenges  

SciTech Connect

Recessed downlights are the most popular residential lighting fixture in the United States representing about 12 percent of installed residential lighting fixtures and 15 percent of total lighting energy use nationwide. We estimate 400 million recessed downlights are currently installed in American homes, almost all using incandescent light sources. In the year 2000, only 0.44 percent of recessed cans sold were hard-wired for using pin-based CFLs. Recessed downlights consume energy in three ways. First, their incandescent light sources use energy directly, drawing 65 to 150 watts. Second, they consume energy indirectly by adding heat from their light sources to air-conditioning loads. Third, since most are not airtight, they also consume energy indirectly by allowing conditioned air to escape into unconditioned areas above the downlights, such as attics. PNNL calculated potential energy savings and found that if a 65W incandescent non-airtight downlight is replaced with a 26W CFL ICAT downlight operated at 3 hrs per day savings will be 126 kWh/yr. Early reflector CFLs have had high return rates primarily because of failure due to thermal related stress. A PNNL laboratory test of ten commercially available R-CFLs selected from retail store shelves showed almost all operated above their manufacturer rated maximum operating temperatures when they were installed and tested in ICAT downlights in a simulated insulated ceiling apparatus. DOE asked PNNL to investigate the development and introduction of both pin-based and screw-based CFLs for use in ICAT fixtures. PNNL invited manufacturers to submit lamps to a procurement program. PNNL conducted short- and long-term thermal testing of the lamps to measure performance parameters affected by elevated temperatures. 8 out of 10 R-CFLs (secrew-based lamps) failed the long-tem testing. Five out of nine CFL-ICAT (pin-based CFL) fixtures passed the long-term test, surviving a full year of operation in a simulated insulated ceiling apparatus, while maintaining at least 80% of initial lumens at 40% of rated life. Of those five products, two were withdrawn from the market due to poor sales, probably because of the high prices on the products. Three remain on the market. PNNL plans to initiate another R-CFL technology procurement in the winter of 2004/2005 to bring more high-quality R-CFL models to market. PNNL developed a number of design ideas for improving the thermal performance of pin-based CFL ICAT downlights for use in future activities.

Ledbetter, Marc R.; McCullough, Jeffrey J.; Dillon, Heather E.; Sandahl, Linda J.; Gordon, Kelly L.



NMR for direct determination of K(m) and V(max) of enzyme reactions based on the Lambert W function-analysis of progress curves.  


(1)H NMR spectroscopy was used to follow the cleavage of sucrose by invertase. The parameters of the enzyme's kinetics, K(m) and V(max), were directly determined from progress curves at only one concentration of the substrate. For comparison with the classical Michaelis-Menten analysis, the reaction progress was also monitored at various initial concentrations of 3.5 to 41.8mM. Using the Lambert W function the parameters K(m) and V(max) were fitted to obtain the experimental progress curve and resulted in K(m)=28mM and V(max)=13?M/s. The result is almost identical to an initial rate analysis that, however, costs much more time and experimental effort. The effect of product inhibition was also investigated. Furthermore, we analyzed a much more complex reaction, the conversion of farnesyl diphosphate into (+)-germacrene D by the enzyme germacrene D synthase, yielding K(m)=379?M and k(cat)=0.04s(-1). The reaction involves an amphiphilic substrate forming micelles and a water insoluble product; using proper controls, the conversion can well be analyzed by the progress curve approach using the Lambert W function. PMID:22079737

Exnowitz, Franziska; Meyer, Bernd; Hackl, Thomas



Autosomal recessive nonsyndromic deafness genes: a review.  


More than 50 Percent of prelingual hearing loss is genetic in origin, and of these up to 93 Percent are monogenic autosomal recessive traits. Some forms of genetic deafness can be recognized by their associated syndromic features, but in most cases, hearing loss is the only finding and is referred to as nonsyndromic deafness. To date, more than 700 different mutations have been identified in one of 42 genes in individuals with autosomal recessive nonsyndromic hearing loss (ARNSHL). Reported mutations in GJB2, encoding connexin 26, makes this gene the most common cause of hearing loss in many populations. Other relatively common deafness genes include SLC26A4, MYO15A, OTOF, TMC1, CDH23, and TMPRSS3. In this report we summarize genes and mutations reported in families with ARNSHL. Founder effects were demonstrated for some recurrent mutations but the most significant findings are the extreme locus and allelic heterogeneity and different spectrum of genes and mutations in each population. PMID:22652773

Duman, Duygu; Tekin, Mustafa



Is the Elimination of Recess in School a Violation of a Child's Basic Human Rights?  

ERIC Educational Resources Information Center

|The elimination of recess in schools across the country is becoming a normal occurrence in many communities, large and small. In each study presented in this content analysis, we find that free time and unstructured play is indeed essential to a child's healthy cognitive development. Article 31 of the United Nations Convention on the Rights of…

Dubroc, Alicia M.



Structural analysis of 6H–SiC( 0 0 0 1 ) surface by RHEED rocking curves  

Microsoft Academic Search

Surface structures of 6H–SiC(0001)3×3R30° and 3×3 reconstructions have been studied by rocking curves of reflection high energy electron diffraction (RHEED) intensities in one-beam condition. The 3×3R30° reconstruction is observed by annealing the Si pre-deposited specimen in the Si flux at 1030°C for 5 min. The 3×3 reconstructions is observed by annealing the Si pre-deposited specimen in the Si flux at

Tomohiro Aoyama; Yujie Han; Ayahiko Ichimiya; Yoshiyuki Hisada; Shinichi Mukainakano



On the minimally invasive approach to the gingival recession.  


Some aspects of pathogenesis and therapeutic approach to the gingival recession are discussed in this short communication with the example of a typical case from Russia, where excessive socket curettage after a tooth extraction resulted in a marked gingival recession. Subgingival plaque and calculus can be secondary to recession. An argument about plaque as a source of microorganisms might be plausible in case of inflammation, although various microorganisms are normal for the oral cavity. From the viewpoint of general pathology, being an atrophic condition, recession can progress due to repeated damage. On the author's opinion, calculus removal is not indicated at least for aged patients with marked gingival recession, having modest esthetic demands. Socket curettage after exodontia should be gentle. Surgical treatment of the gingival recession is beyond the scope of this communication. PMID:24049345

Jargin, Sergei V



On the minimally invasive approach to the gingival recession  

PubMed Central

Some aspects of pathogenesis and therapeutic approach to the gingival recession are discussed in this short communication with the example of a typical case from Russia, where excessive socket curettage after a tooth extraction resulted in a marked gingival recession. Subgingival plaque and calculus can be secondary to recession. An argument about plaque as a source of microorganisms might be plausible in case of inflammation, although various microorganisms are normal for the oral cavity. From the viewpoint of general pathology, being an atrophic condition, recession can progress due to repeated damage. On the author's opinion, calculus removal is not indicated at least for aged patients with marked gingival recession, having modest esthetic demands. Socket curettage after exodontia should be gentle. Surgical treatment of the gingival recession is beyond the scope of this communication.

Jargin, Sergei V.



A rare case of respiratory disorders associated with two autosomal recessive diseases and male infertility.  


The study of nasal ciliary beat frequency (CBF) and ultrastructure may contribute to the understanding of pathognomonic cases of male infertility associated with defects in sperm motility. This study was designed to report a particular case of male infertility, characterized by the association of two respiratory autosomal recessive genetic diseases (alpha-1-antitrypsin deficiency [AAT-D] and primary ciliary dyskinesia [PCD]). A 39-year-old patient with complete sperm immotility, AAT-D, and bronchiectasis was studied in the Laboratory of Male Fertility, the Department of Urology, the Respiratory Center of a Pediatric Hospital, and in the Department of Clinical Medicine of a Rehabilitation Respiratory Hospital. Family history, physical examination, hormonal analysis, microbial assays, semen analysis, nasal ciliary function, and structure study by digital high-speed video photography and transmission electron microscopy are described. A noninvasive nasal biopsy to retrieve ciliated epithelium lining the inferior surface of the inferior nasal turbinates was performed and CBF was determined. Beat pattern was slightly curved and rigid, not wide, and metacronic in all the observed fields analyzed. CBF was 8.2 Hz in average (reference value, 10-15 Hz) Ultrastructural assay revealed absence of the inner dynein arms in 97% of the cilia observed. The final infertility accurate diagnosis was achieved by the study of nasal CBF and ultrastructure contributing to the patient health management and genetic counseling while deciding fatherhood. Beyond this particular case, the present report may open a new field of studies in male infertility, mainly in cases of asthenozoospermia. PMID:23772318

Mendeluk, Gabriela Ruth; Costa, Sergio López; Scigliano, Sergio; Menga, Guillermo; Demiceu, Sergio; Palaoro, Luis Alberto



The 10 autosomal recessive limb-girdle muscular dystrophies  

Microsoft Academic Search

Fifteen forms of limb-girdle muscular dystrophies (5 autosomal dominant and 10 autosomal recessive) have already been found. The 10 genes responsible for the autosomal recessive forms, which account for more than 90% of the cases, had their product identified. This review will focus on the most recent data on autosomal recessive-limb-girdle muscular dystrophy and on our own experience of more

Mayana Zatz; Flavia de Paula; Alessandra Starling; Mariz Vainzof



Detection of a Knockdown Resistance Mutation Associated with Permethrin Resistance in the Body Louse Pediculus humanus corporis by Use of Melting Curve Analysis Genotyping  

PubMed Central

Louse-borne diseases are prevalent in the homeless, and body louse eradication has thus far been unsuccessful in this population. We aim to develop a rapid and robust genotyping method usable in large field-based clinical studies to monitor permethrin resistance in the human body louse Pediculus humanus corporis. We assessed a melting curve analysis genotyping method based on real-time PCR using hybridization probes to detect the M815I-T917I-L920F knockdown resistance (kdr) mutation in the paraorthologous voltage-sensitive sodium channel (VSSC) ? subunit gene, which is associated with permethrin resistance. The 908-bp DNA fragment of the VSSC gene, encoding the ? subunit of the sodium channel and encompassing the three mutation sites, was PCR sequenced from 65 lice collected from a homeless population. We noted a high prevalence of the 3 indicated mutations in the body lice collected from homeless people (100% for the M815I and L920F mutations and 56.73% for the T917I mutation). These results were confirmed by melting curve analysis genotyping, which had a calculated sensitivity of 100% for the M815I and T917I mutations and of 98% for the L920F mutation. The specificity was 100% for M815I and L920F and 96% for T917I. Melting curve analysis genotyping is a fast, sensitive, and specific tool that is fully compatible with the analysis of a large number of samples in epidemiological surveys, allowing the simultaneous genotyping of 96 samples in just over an hour (75 min). Thus, it is perfectly suited for the epidemiological monitoring of permethrin resistance in human body lice in large-scale clinical studies.

Drali, Rezak; Benkouiten, Samir; Badiaga, Sekene; Bitam, Idir



Parameter Estimation and Confidence Regions in the Method of Light Curve Simulations for the Analysis of Power Density Spectra  

SciTech Connect

The Method of Light Curve Simulations is a tool that has been applied to X-ray monitoring observations of Active Galactic Nuclei (AGN) for the characterization of the Power Density Spectrum (PDS) of temporal variability and measurement of associated break frequencies (which appear to be an important diagnostic for the mass of the black hole in these systems as well as their accretion state). It relies on a model for the PDS that is fit to the observed data. The determination of confidence regions on the fitted model parameters is of particular importance, and we show how the Neyman construction based on distributions of estimates may be implemented in the context of light curve simulations. We believe that this procedure offers advantages over the method used in earlier reports on PDS model fits, not least with respect to the correspondence between the size of the confidence region and the precision with which the data constrain the values of the model parameters. We plan to apply the new procedure to existing RXTE and XMM observations of Seyfert I galaxies as well as RXTE observations of the Seyfert II galaxy NGC 4945.

Mueller, M.; Madejski, G.




SciTech Connect

The method of light-curve simulations is a tool that has been applied to X-ray monitoring observations of active galactic nuclei for the characterization of the power density spectrum (PDS) of temporal variability and measurement of associated break frequencies (which appear to be an important diagnostic for the mass of the black hole in these systems as well as their accretion state). It relies on a model for the PDS that is fitted to the observed data. The determination of confidence regions on the fitted model parameters is of particular importance, and we show how the Neyman construction based on distributions of estimates may be implemented in the context of light-curve simulations. We believe that this procedure offers advantages over the method used in earlier reports on PDS model fits, not least with respect to the correspondence between the size of the confidence region and the precision with which the data constrain the values of the model parameters. We plan to apply the new procedure to existing RXTE and XMM-Newton observations of Seyfert I galaxies as well as RXTE observations of the Seyfert II galaxy NGC 4945.

Mueller, Martin; Madejski, Greg [Kavli Institute for Particle Astrophysics and Cosmology, SLAC National Accelerator Laboratory, 2575 Sand Hill Road, Menlo Park, CA 94025 (United States)], E-mail:



Estimation of the initial velocity of enzyme-catalysed reactions by non-linear regression analysis of progress curves.  

PubMed Central

Most methods for studying the kinetic properties of an enzyme involve the determination of initial velocities. When the reaction progress curve shows significant curvature due to depletion of the substrate, accumulation of inhibitory products or instability of the enzyme, estimation of the initial velocity is a subjective and inexact process. Two methods have been suggested [Cornish-Bowden (1975) Biochem. J. 144, 305-312; Boeker (1982) Biochem J. 203, 117-123] that attempt to eliminate this subjective element. The present study offers a third alternative, which is based on fitting a reparameterized form of the integrated Michaelis-Menten equation to the progress curves by non-linear regression. This method yields estimates and standard errors of the initial velocity and of the time to reach 50% reaction. No prior knowledge of the apparent product concentration at zero time or infinite time is required, since both of these quantities are also estimated from the data. It is shown that this method yields reliable estimates of the initial velocity under a wide range of circumstances, including those where the two previously published methods perform poorly.

Duggleby, R G



Interpretation of Surface Dynamics and Bond Strengths of Polystyrene Microspheres on a Quartz Crystal Microbalance by Analysis of Decoupling Curves  

NASA Astrophysics Data System (ADS)

In this study we have analyzed the behavior of 5?m diameter polystyrene spheres deposited from aqueous solution on the electrode of a quartz crystal microbalance (QCM). By varying the driving voltage of the QCM, the samples exhibit a frequency response with respect to the crystal amplitude (``decoupling curve''). Decoupling curves provide information about the friction, via changes in the coupling between the spheres and the QCM surface as the oscillation amplitude is swept forward and backward. Qualitative information in regards to the change in coupling and surface dynamics can be backed out using known QCM frequency response models.footnotetextDybwad, G.L. J. Appl. Phys. 1985, 58, 2789^,footnotetextFlanigan, C.M.; Desai, M.; Shull, K.R. Langmuir 2000, 16, 9825 Optical observations show that the particle motion is dependent on the oscillation direction and surface topology of the QCM. Optically observed sliding motion as well as preliminary data on detection of microsphere transfer from adjacent QCMs will also be reported on.

Lynch, Iyam; Krim, Jacqueline



Analysis of creep curves in a 9Cr-1Mo modified steel by means of simple constitutive equations  

SciTech Connect

One of the more physically sound relationships for primary and secondary creep rate is the Li-Akulov equation. The aim of the present paper is to extend the application of the equation to a set of creep data obtained from a modified 9Cr-1Mo steel, in order to establish a basis for interpolation and extrapolation that could be used for a correct design of the component. At a constant temperature, when the experimental data are normalized by means of the {dot {var_epsilon}}{sub m} and t{sub m} parameters, all the creep data superimpose on a single master curve, irrespective of the applied stress; t{sub m} can be related to the minimum creep rate by means of a modified form of the Monkman-Grant relationship; {dot {var_epsilon}} depends on applied stress and temperature by a power law equation where the stress n exponent is a linear function of 1/T; both the high value of the activation energy Q and of n suggest that in the high stress regime creep strain is controlled by dislocation movement and particle-dislocation interaction (Orowan by pass and/or climb). A set of constitutive equations can be used to calculate the creep curves for the studied steel under different applied stresses; the resulting model can give very interesting information on the behavior of the steel under the operating condition, once the viscous component of the strain is taken into account.

Spigarelli, S. [Univ. of Ancona (Italy). Dept. of Mechanics; Kloc, L. [Academy of Science of Czech Republic, Brno (Czech Republic). Inst. of Physics of Materials; Bontempi, P. [ENEL-CRAM, Milano (Italy)



Construction of an Earth Model: Analysis of Exoplanet Light Curves and Mapping the Next Earth with the New Worlds Observer  

NASA Astrophysics Data System (ADS)

The orbital light curve of a terrestrial exoplanet will likely contain valuable information about the surface and atmospheric features of the planet, both in its overall shape and hourly variations. We have constructed an empirically based code capable of simulating observations of the Earth from any orientation, at any time of year with continuously updated cloud and snow coverage with a New Worlds Observatory. By simulating these observations over a full orbital revolution at a distance of 10 pc we determine that the detection of an obliquity or seasonal terrain change is possible at low inclinations. In agreement with other studies, a 4 m New Worlds Observer can accurately determine the rotation rate of the planet at a success rate from ~30% to 80% with only 5 days of observations depending on the signal to noise of the observations. We also attempt simple inversions of these diurnal light curves to sketch a map of the reflecting planet's surface features. This mapping technique is only successful with highly favorable systems and in particular requires that the cloud coverage must be lower than the Earth's average. Our test case of a 2 M ? planet at 7 pc distance with low exo-zodiacal light and 25% cloud coverage produced crude, but successful results. Additionally, with these highly favorable systems NWO may be able to discern the presence of liquid surface water (or other smooth surfaces) though it requires a complex detection available only at crescent phases in high inclination systems.

Oakley, P. H. H.; Cash, W.



The Periodicity Analysis of the Light Curve of 3C 279 and Implications for the Precession Jet  

NASA Astrophysics Data System (ADS)

We have analyzed the light curves of 3C 279 at 22 GHz, 37 GHz, optical R band, and X-ray (2-10 KeV), and found evidence of quasi-periodic outbusts. The light curves show that 3C 279 is an extremely active object. A period of P=130.6±1.3 days was consistently confirmed by three methods: the power-spectrum method, the discrete correlation function (DCF) method, and the Jurkevich method. Based on the relationship between observed period P and the precession period P given by Rieger and our result, the precession period of jet in 3C 279 is P?29.6 yr, which is completely consistent with the precession period of jet of about 30 yr obtained by Carrara et al.. This suggests that there is a precession jet in 3C 279 and the variability period of about 130.6 days that we obtained is most likely caused by the helical motion of the jet.

Li, H. Z.; Xie, G. Z.; Chen, L. E.; Dai, H.; Lei, B. Y.; Yi, T. F.; Ren, J. Y.



The last recession was good for life expectancy.  


Most people think that economic growth and a good economy are prerequisites for good health and high life expectancy. As such, a recession should decrease life expectancy or stop it from rising. In fact, recessions can boost life expectancy. This was the case during the Great Depression in the United States from 1929 to 1932 and during the recession in the European Union in 2009. In 2009, life expectancy increased most rapidly in European countries where the decrease in gross domestic product was greatest-Estonia, Latvia, and Lithuania. Studies of life expectancy increasing during recessions can yield valuable information regarding extending average life expectancy without essential costs. PMID:22533416

Kristjuhan, Ulo; Taidre, Erika



Fourier Descriptors for Plane Closed Curves  

Microsoft Academic Search

A method for the analysis and synthesis of closed curves in the plane is developed using the Fourier descriptors FD's of Cosgriff [1]. A curve is represented parametrically as a function of arc length by the accumulated change in direction of the curve since the starting point. This function is expanded in a Fourier series and the coefficients are arranged

Charles T. Zahn; Ralph Z. Roskies



Optimization of supervised cluster analysis for extracting reference tissue input curves in (R)-[11C]PK11195 brain PET studies  

PubMed Central

Performance of two supervised cluster analysis (SVCA) algorithms for extracting reference tissue curves was evaluated to improve quantification of dynamic (R)-[11C]PK11195 brain positron emission tomography (PET) studies. Reference tissues were extracted from images using both a manually defined cerebellum and SVCA algorithms based on either four (SVCA4) or six (SVCA6) kinetic classes. Data from controls, mild cognitive impairment patients, and patients with Alzheimer's disease were analyzed using various kinetic models including plasma input, the simplified reference tissue model (RPM) and RPM with vascular correction (RPMVb). In all subject groups, SVCA-based reference tissue curves showed lower blood volume fractions (Vb) and volume of distributions than those based on cerebellum time-activity curve. Probably resulting from the presence of specific signal from the vessel walls that contains in normal condition a significant concentration of the 18?kDa translocation protein. Best contrast between subject groups was seen using SVCA4-based reference tissues as the result of a lower number of kinetic classes and the prior removal of extracerebral tissues. In addition, incorporation of Vb in RPM improved both parametric images and binding potential contrast between groups. Incorporation of Vb within RPM, together with SVCA4, appears to be the method of choice for analyzing cerebral (R)-[11C]PK11195 neurodegeneration studies.

Yaqub, Maqsood; van Berckel, Bart NM; Schuitemaker, Alie; Hinz, Rainer; Turkheimer, Federico E; Tomasi, Giampaolo; Lammertsma, Adriaan A; Boellaard, Ronald



Rapid and accurate identification of species belonging to the Candida parapsilosis complex by real-time PCR and melting curve analysis.  


Candida parapsilosis is the second most frequent Candida species isolated from blood cultures. Since 2005, C. parapsilosis has been divided into three distinct species based on genetic traits: Candida parapsilosis, Candida metapsilosis and Candida orthopsilosis. The aim of this study was to develop a rapid real-time PCR assay able to distinguish these closely related species via a melting curve analysis. This identification method was optimized by using reference strains and well-characterized clinical isolates of Candida species. A single set of consensus primers was designed to amplify a 184 bp portion of the SADH gene in order to identify species based on the unique melt profile resulting from DNA sequence variations from each species of the complex. PCR products were detected with SYBR Green fluorescent dye and identification was established by melting curve analysis. For validation of the technique, a total of 116 clinical isolates, phenotypically identified as C. parapsilosis, were tested by real-time PCR and results were further compared with PCR-RFLP patterns of the SADH gene, used as the reference method. The melting curve analysis of amplified DNA could differentiate between C. parapsilosis (83.5 °C), C. metapsilosis (82.9 °C) and C. orthopsilosis (82.1 °C), with a sensitivity and specificity comparable to those of the reference method. One hundred and fourteen C. parapsilosis and two C. orthopsilosis isolates were identified among the clinical isolates. This method provides a simple, rapid and reliable identification of species belonging to the C. parapsilosis complex. This novel approach could be helpful for clinical and epidemiological investigations. PMID:21183600

Hays, Constantin; Duhamel, Chantal; Cattoir, Vincent; Bonhomme, Julie



Analysis of progress curves for a highly concentrated Michaelian enzyme in the presence or absence of product inhibition.  

PubMed Central

Methods are given for analysing the time course of an enzyme-catalysed reaction when the concentration of the enzyme itself is high, a situation which is often found in vivo. (1) The integrated form of the kinetic equation for a concentrated Michaelian enzyme in absence of product inhibition is given. Parameters are shown to be calculated easily using non-linear fitting procedures. (2) A general algorithm to analyse progress-curve data in more complex cases (i.e. when the analytical form of the integrated rate equation is not known or is exceedingly complex) is proposed. This algorithm may be used for any enzyme mechanism for which the differential form of the kinetic equation may be written analytically. We show that the method allows differentiation between the main types of product inhibition which may occur in the case of a highly concentrated Michaelian enzyme.

Kellershohn, N; Laurent, M



Analysis of time-dependent conjugation of gold nanoparticles with an antiparkinsonian molecule by using curve resolution methods.  


In this work, the time-dependent conjugation process between a thiolated molecule (with anti-parkinsonian properties) and gold nanoparticles has been monitored and studied by the combined use of fast acquisition Ultra Violet-Visible (UV-Vis) spectra and the ability of Multivariate Curve Resolution-Alternating Least Squares (MCR-ALS) technique. From the highly informative kinetic profiles obtained it was possible to extract quantitative and qualitative information of the conjugation process which includes i) time-dependent concentration profiles and pure spectra of species involved on conjugation process, ii) estimation of molecule concentration necessary for the completeness of the conjugation reaction, iii) molecule footprint and iv) free energy of molecule adsorption. PMID:21167967

Amigo, José Manuel; Bastús, Neus G; Hoen, Rob; Vázquez-Campos, Socorro; Varón, Miriam; Royo, Miriam; Puntes, Victor



Pre-curving analysis of an opening crack in a magnetoelectroelastic strip under in-plane impact loadings  

NASA Astrophysics Data System (ADS)

An opening crack in a magnetoelectroelastic strip under in-plane mechanical, electric, and magnetic impact loadings is considered for magneto-electrically impermeable and permeable crack surface boundary conditions. Laplace and Fourier transforms are applied to reduce the mixed boundary value problem of the crack to dual integral equations, which are expressed in terms of Fredholm integral equations of the second kind. The asymptotic fields near the crack tip are obtained in explicit form and the corresponding field intensity factors are defined. The crack curving phenomena are investigated by applying the criterion of maximum hoop stress intensity factors. Numerical results show that the hoop stress intensity factors are influenced by the electric and magnetic loadings and the geometric size ratios.

Hu, Keqiang; Chen, Zengtao



Estimation of recession curve of karst spring hydrograph: example of the spring Gradole  

Microsoft Academic Search

The spring Gradole represents a typical karst spring of the rising type, which is situated in central part of Istria (Croatia). The drainage area is composed mostly of carbonate rocks (limestone) and partly of flysch components (marls and sandstones). The average altitude of the catchment area is approximately 330 m a.s.l. Strong tectonic deformations have made carbonate deposits very permeable,

V. Denic-Jukic; K. Kustera; D. Jukic



[The decline in population growth, income distribution, and economic recession].  


This work uses Keynesian principles and an analysis of the Colombian population in the 1970s to argue that the Colombian policy of slowing population growth, which was adopted with the aim of improving the general welfare of the population, has had shortterm negative effects on effective demand and thus on the level of employment and welfare. These negative effects were caused by the inflexibility of income distribution, which prevented expansion of the internal market, complicated by the stagnant condition of the external sector and the budget deficit. The results of the Colombian case study demonstrate how the deceleration of population growth beginning in the 1960s had a significant impact on the levels of consumption and savings and on the patterns of consumption, leading to low levels of investment and little dynamism. Although the current Colombian economic recession is aggravated by contextual factors such as the world economic recession, the high cost of capital, the industrial recession, and declining food production among others, at the core of the crisis are longer term structural determinants such as the decline in the rate of population growth and the highly unequal distribution of income and wealth, which have contributed to a shrinking of the internal market for some types of goods. Given the unlikelihood of renewed rapid population growth, the Keynesian model suggests that the only alternative for increasing aggregate demand is state intervention through public spending and investment and reorientation of the financial system to achieve a dynamic redistribution of income. Based on these findings and on proposals of other analysts, a stragegy for revitalization is proposed which would imply a gradual income redistribution to allow increased consumption of mass produced goods by the low income groups. Direct consumption subsidies would be avoided because of their inflationary and import-expanding tendencies; rather, incentives and support would be provided to 3 productive sectors: traditional agriculture, small factories producing mass consumption goods, and construction of low income housing. The strategy would promote economic growth and expansion without further deterioration of income distribution, employment, and price stability. A simulation study demonstrated the advantages of such a strategy in relation to alternative strategies. PMID:12266019

Banguero, H



Reliability of radionuclide gastroesophageal reflux studies using visual and time-activity curve analysis: inter-observer and intra-observer variation and description of minimum detectable reflux.  


Radionuclide studies have gained wide acceptance in the evaluation of infants and children with gastroesophageal reflux (GER). For correct interpretation of scan results, knowledge of inter-observer and intra-observer variability and minimum detectable reflux volume is essential. In this study, we evaluated the methodological issues underlying the visual assessment of GER and time activity curve analysis. An in vitro model of stomach and oesophagus was established to determine the minimum detectable reflux by placing various volumes and concentrations representing the diluted activity in the stomach. In the clinical part 99 patients were imaged for 1 h after oral administration of 99mTc sulfur colloid. Eleven patients were excluded from the study either due to incomplete clinical data or suboptimal image quality. Frames of 16 s each, and time-activity curves which were generated after drawing regions of interest from the oesophagus, were read three times by an experienced nuclear medicine physician and a resident in training. On the phantom study, the concentration, volume and duration were the determining factor for the visualization of reflux. In the clinical part, the overall incidence of GER in 88 patients was 69%. The mean intra- and inter-observer reproducibility (kappa values) was 0.76 and 0.7065, respectively. Agreement was slightly higher in the analysis of time-activity curves (0.767 and 0.731). Our results indicate that GER may be reproducibly analysed on scintigraphy by the same and different observers with varying levels of training. Its visualization is associated with reflux duration, volume and dilution factor of radioactivity. PMID:12673171

Caglar, M; Volkan, B; Alpar, R



Mechanisms of Disease: autosomal dominant and recessive polycystic kidney diseases  

Microsoft Academic Search

Autosomal dominant polycystic kidney disease and autosomal recessive polycystic kidney disease are the best known of a large family of inherited diseases characterized by the development of renal cysts of tubular epithelial cell origin. Autosomal dominant and recessive polycystic kidney diseases have overlapping but distinct pathogeneses. Identification of the causative mutated genes and elucidation of the function of their encoded

Peter C Harris; Vicente E Torres



The Impact of the Recession on College Students  

ERIC Educational Resources Information Center

|This article had three goals: (a) to provide a brief economic review of the relationship between recessionary times, institutional reactions, and the life trajectory of recession-era college students; (b) to discuss the recession-related psychosocial stressors facing today's college students; and (c) to discuss how counseling centers can help…

Berg-Cross, Linda; Green, Rodney



Ecology and Management of the Spring Snowmelt Recession  

Microsoft Academic Search

We present a conceptual model for the ecology of the spring snowmelt recession, delineating components of the natural flow regime most relevant to the recession hydrograph and their relation to physical and biological stream processes. Using general principles to describe expected responses in stream ecosystems, we specifically relate the quantifiable components of magnitude, timing and rate of change to abiotic

S. Yarnell; J. H. Viers; J. F. Mount



Recess Physical Activity Packs in Elementary Schools: A Qualitative Investigation  

ERIC Educational Resources Information Center

|To supplement the present weekly allotment of 30 minutes of physical education, a school district in southeastern North Carolina identified recess time as part of the state mandated (HSP-S-000) 150 minutes of physical activity (PA) per week and have purchased fitness equipment (recess packs) for the children to use. Twelve participants were…

Elliott, Steven; Combs, Sue; Boyce, Robert



A study on Performance Management through Recession Metrics during Downturn  

Microsoft Academic Search

Recession indeed presents a very difficult time for any existing enterprise in today’s corporate world and no company is exempted from this truth. It is essential for every company to know how to implement the right metric set for this very trying period. Performance management through recession metrics implemented is indeed a must. Employee morale is one thing that is

Dash Bidya



Relatively Mild Recession in 1993. Austria's Economy in 1993  

Microsoft Academic Search

In Austria the recession of 1993 was mild relative to other countries. Real GDP declined by 0.3 percent. Exports, tourism, and investment in machinery were hard hit by the slump. Consumption and construction activity helped to stabilize the economy. Austria, with its small, open economy, was not able to escape the effects of the recession in Europe and of the

Ewald Walterskirchen



A phenotypic effect of heterozygous recessive white in the fowl  

Microsoft Academic Search

1. The dominance of the allele C of the recessive white gene c was previously thought to represent one of the relatively uncommon examples of complete dominance in the fowl.2. In a study with cockerel?breeding Partridge Wyandotte Bantams, dilution effects on both phaeomelanin and eumelanin were observed in C+ heterozygotes indicating that C+ is not completely dominant over its recessive

W. C. Carefoot



Chemical-mechanical polishing of recessed microelectromechanical devices  

Microsoft Academic Search

A method is disclosed for micromachining recessed layers (e.g. sacrificial layers) of a microelectromechanical system (MEMS) device formed in a cavity etched into a semiconductor substrate. The method uses chemical-mechanical polishing (CMP) with a resilient polishing pad to locally planarize one or more of the recessed layers within the substrate cavity. Such local planarization using the method of the present

C. C. Barron; D. L. Hetherington; S. Montague



Recessive Mutations and the Maintenance of Sex in Structured Populations  

Microsoft Academic Search

The evolutionary maintenance of sexual reproduction remains a controversial problem. It was recently shown that recessive deleterious mutations create differences in the mutation load of sexual vs. asexual populations. Here we show that low levels of population structure or inbreeding can greatly enhance the importance of recessive deleterious mutations in the context of sexual vs. asexual populations. With population structure,

Aneil F. Agrawal; J. R. Chasnov



The Anterior Epitympanic Recess: CT Anatomy and Pathology  

Microsoft Academic Search

PURPOSE: To describe the variation in size and shape of the anterior epitympanic recess and to discuss pathologic processes that affect this space. METHODS: Axial CT scans of the temporal bones of 31 adults and 19 children were reviewed retrospectively to ascertain the morphology and size of the anterior epitympanic recess. Selected confirmed disease processes involving this space were studied.

L. V. Petrus; W. W. M. Lo


How does forest disturbance and succession affect summer streamflow recession?  

NASA Astrophysics Data System (ADS)

Streamflow recession is a main signature of catchment behavior during dry conditions. The storage-discharge relationship of every catchment reflects the aquifer properties and land surface processes including evapotranspiration rates. Commonly, the storage-discharge relationship in watersheds is analyzed through the recession limb of the hydrograph, which generally follows a nonlinear pattern. It is, however, unknown how forest disturbance and succession may modify the degree of nonlinearity of baseflow recession and the magnitude of baseflow. The presented study analyzes and characterizes streamflow recession during summer before and after forest disturbance using data from six experimental paired-watersheds with controlled forest disturbances across different climatic regions and ecozones of the USA. Characteristic non-linear recession parameters were fitted by a Monte Carlo resampling method. No systematic relationship was found between annual precipitation, drainage area, mean elevation, and recession characteristics. However, higher storage rates and low flows across the sites were detected following forest disturbance. Exceptions are the snow-dominated watersheds and changes appear to be stronger in watersheds with deciduous forests. The results are however dependent on the method of recession limb selection, including start level and time. Further research is needed over a wide range of forest sites and according to the type of disturbance (e.g. fire, disease), which may ultimately define the dynamics of forest succession and therefore the streamflow recession behavior.

Brena, A.; Stahl, K.; Weiler, M.



The Credit Crisis and Recession as a Paradigm Test  

Microsoft Academic Search

This paper contributes to the debate on what economics can learn from the credit crisis and recession. It asks what are the elements in the mainstream paradigm that caused many economists to misjudge the state of the economy so dramatically in the years leading up to the 2007 credit crisis and the 2008-2009 recession. It scrutinizes the work of twelve

Dirk J. Bezemer



Unemployment and inactivity in the 2008–2009 recession  

Microsoft Academic Search

SUMMARYThis article looks at the pattern of worklessness, that is unemployment and inactivity, in the latest recession. Compared to previous recessions, the rise in unemployment has been small relative to the fall in Gross Domestic Product. Likewise, numbers receiving workless benefits other than for unemployment are not rising, in contrast to the two previous economic downturns. This suggests that labour

Paul Gregg; Jonathan Wadsworth



Far-Ultraviolet Phase Curve Analysis Of Mimas, Tethys And Dione And Implications For The Exogenic Processes  

NASA Astrophysics Data System (ADS)

The Cassini probe orbiting in the Saturn system since 2004 provides the first opportunity to observe the midsize icy satellites of Saturn in the Far-UV wavelengths, between 118 and 190 nm, thanks to the UVIS (UltraViolet Imaging Spectrograph) instrument. Data collected over these 9 last years allow to study much more in details the photometric properties and exogenic processes acting on the surface of the icy satellites. To date, very few things are known about these satellites and their environment, the E-ring. We present here he first far-UV phase curves of three midsize Saturnian satellites: Mimas, Tethys and Dione. The photometric characteristics of Tethys and Dione, exterior to the orbit of Enceladus, are compared and contrasted with the ones of Mimas, inside the orbit of Enceladus, the source of the E-ring. While the leading/trailing hemisphere patterns on Tethys and Dione correspond to the expectations previous by the model of repartition of the E-ring grains inside the E-ring (Hamilton and Burns, 1994), Mimas exhibits an unexpected behavior being much brighter than expected, especially at low phase angles. Exogenic processes acting on the surface are thus questioned. E-ring grains, energetic electrons, cold plasma ions and neutrals are known to impact these icy surfaces. The Hapke an Buratti models applied to our dataset provide some supplementary details to understand the ring-satellite-magnetosphere interactions in the Saturnian System.

Royer, Emilie M.; Hendrix, A. R.



Adherence to Pediatric Asthma Treatment in Economically Disadvantaged African-American Children and Adolescents: An Application of Growth Curve Analysis  

PubMed Central

Objectives?The primary aims of the study were to: (a) describe the trajectories of adherence to daily inhaled corticosteroid (ICS) medication for a year in economically disadvantaged, African-American youth with asthma based on growth curve modeling; and (b) test the relationship of treatment adherence to symptom control, quick-relief medication, and healthcare utilization.?Methods?This prospective study measured adherence to daily ICS treatment using electronic monitoring in 92 children and adolescents with moderate to severe asthma for 9–12 months and assessed clinical outcomes, including asthma-related symptoms, quick-relief medication, and healthcare utilization.?Results?Youth showed a decrement in treatment adherence to less than half of prescribed corticosteroid treatment over the course of the study, which related to increased healthcare utilization (p < .04), but not to asthma symptoms or albuterol use.?Conclusion?Economically disadvantaged youth with asthma demonstrate high rates of chronic nonadherence that warrant identification and intervention to reduce asthma-related healthcare utilization.

Drotar, Dennis; McNally, Kelly; Schluchter, Mark; Riekert, Kristin; Vavrek, Pamela; Schmidt, Amy; Redline, Susan; Kercsmar, Carolyn



Growth Curve Models for the Analysis of Phenotype Arrays for a Systems Biology Overview of Yersinia pestis  

SciTech Connect

The Phenotype MicroArray technology of Biolog, Inc. (Hayward, CA) measures the respiration of cells as a function of time in thousands of microwells simultaneously, and thus provides a high-throughput means of studying cellular phenotypes. The microwells contain compounds involved in a number of biochemical pathways, as well as chemicals that test the sensitivity of cells against antibiotics and stress. While the PM experimental workflow is completely automated, statistical methods to analyze and interpret the data are lagging behind. To take full advantage of the technology, it is essential to develop efficient analytical methods to quantify the information in the complex datasets resulting from PM experiments. We propose the use of statistical growth-curve models to rigorously quantify observed differences in PM experiments, in the context of the growth and metabolism of Yersinia pestis cells grown under different physiological conditions. The information from PM experiments complement genomic and proteomic results and can be used to identify gene function and in drug development. Successful coupling of phenomics results with genomics and proteomics will lead to an unprecedented ability to characterize bacterial function at a systems biology level.

Fodor, I K; Holtz-Morris, A E; McCutchen-Maloney, S L



Distal and proximal family predictors of adolescents' smoking initiation and development: A longitudinal latent curve model analysis  

PubMed Central

Background Studies on adolescent smoking indicate that the smoking behaviours of their parents, siblings and friends are significant micro-level predictors. Parents' socioeconomic status (SES) is an important macro-level predictor. We examined the longitudinal relationships between these predictors and the initiation and development of adolescents' smoking behaviour in Norway. Methods We employed data from The Norwegian Longitudinal Health Behaviour Study (NLHB), in which participants were followed from the age of 13 to 30. We analysed data from the first 5 waves, covering the age span from 13 to 18, with latent curve modeling (LCM). Results Smoking rates increased from 3% to 31% from age 13 to age 18. Participants' smoking was strongly associated with their best friends' smoking. Parental SES, parents' smoking and older siblings' smoking predicted adolescents' initial level of smoking. Furthermore, the same variables predicted the development of smoking behaviour from age 13 to 18. Parents' and siblings' smoking behaviours acted as mediators of parents' SES on the smoking habits of adolescents. Conclusions Parents' SES was significantly associated, directly and indirectly, with both smoking initiation and development. Parental and older siblings' smoking behaviours were positively associated with both initiation and development of smoking behaviour in adolescents. There were no significant gender differences in these associations.



Noise reduction methods in the analysis of near infrared lunar occultation light curves for high angular resolution measurements  

NASA Astrophysics Data System (ADS)

A lunar occultation (LO) technique in the near-infrared (NIR) provides angular resolution down to milliarcseconds for an occulted source, even with ground-based 1 m class telescopes. LO observations are limited to brighter objects because they require a high signal-to-noise ratio (S/N ~40) for proper extraction of angular diameter values. Hence, methods to improve the S/N ratio by reducing noise using Fourier and wavelet transforms have been explored in this study. A sample of 54 NIR LO light curves observed with the IR camera at Mt Abu Observatory has been used. It is seen that both Fourier and wavelet methods have shown an improvement in S/N compared to the original data. However, the application of wavelet transforms causes a slight smoothing of the fringes and results in a higher value for angular diameter. Fourier transforms which reduce discrete noise frequencies do not distort the fringe. The Fourier transform method seems to be effective in improving the S/N, as well as improving the model fit, particularly in the fainter regime of our sample. These methods also provide a better model fit for brighter sources in some cases, though there may not be a significant improvement in S/N.

Baug, Tapas; Chandrasekhar, Thyagarajan



[Estimation of aortic time-enhancement curve in pharmacokinetic analysis: dynamic study by multi-detector row computed tomography].  


This paper presents an introduction to the development of software that provides a physiologic model of contrast medium enhancement by incorporating available physiologic data and contrast medium pharmacokinetics to predict an organ-specific aortic time-enhancement curve(TEC)in computed tomography(CT)with various contrast medium injection protocols in patients of various heights, weights, cardiac output levels, and so on. The physiologic model of contrast medium enhancement was composed of six compartments for early contrast enhancement pharmacokinetics. Contrast medium is injected via the antecubital vein and distributed to the right side of the heart, the pulmonary compartment, the left side of the heart, and the aorta. It then circulates back to the right side of the heart via the systemic circulation. A computer-based, compartmental model of the aortic system was generated using human physiologic parameters and six differential equations to describe the transport of contrast medium. Aortic TEC generated by the computer-based physiologic model of contrast medium enhancement showed validity and agreement with clinical data and findings published previously. A computer-based physiologic model that may help predict organ-specific CT contrast medium enhancement for different injection protocols was developed. Such a physiologic model may have multiple clinical applications. PMID:17625352

Yamaguchi, Isao; Hayashi, Hiroyuki; Suzuki, Masayuki; Kidoya, Eiji; Higashimura, Kyoji



Efficacy of atomoxetine in adult attention-Deficit/Hyperactivity Disorder: a drug-placebo response curve analysis  

PubMed Central

Background The objective of this study was to evaluate the efficacy of atomoxetine, a new and highly selective inhibitor of the norepinephrine transporter, in reducing symptoms of attention-deficit/hyperactivity disorder (ADHD) among adults by using drug-placebo response curve methods. Methods We analyzed data from two double-blind, placebo-controlled, parallel design studies of adult patients (Study I, N = 280; Study II, N = 256) with DSM-IV-defined ADHD who were recruited by referral and advertising. Subjects were randomized to 10 weeks of treatment with atomoxetine or placebo, and were assessed with the Conners Adult ADHD Rating Scales and the Clinical Global Impression of ADHD Severity scale before and after treatment. Results Those treated with atomoxetine were more likely to show a reduction in ADHD symptoms than those receiving placebo. Across all measures, the likelihood that an atomoxetine-treated subject improved to a greater extent than a placebo-treated subject was approximately 0.60. Furthermore, atomoxetine prevented worsening of most symptom classes. Conclusion From these findings, we conclude that atomoxetine is an effective treatment for ADHD among adults when evaluated using several criteria.

Faraone, Stephen V; Biederman, Joseph; Spencer, Thomas; Michelson, David; Adler, Lenard; Reimherr, Fred; Glatt, Stephen J



Comparative study of the performance on a constant flow annular hydrostatic thrust bearing having multi-circular recess and sector recess  

Microsoft Academic Search

A theoretical comparative study concerning performance of a constant flow hydrostatic thrust bearing having multi-circular recess and sector recess is described. The Computational Fluid Dynamics and the Finite Volume Method have been used to compute the characteristics of a constant fluid hydrostatic thrust bearing with circular and sector recesses. The performance has been compared, namely, recess pressure, pressure distribution and

Xiaodong Yu; Xiuli Meng; Junpeng Shao; Yanqin Zhang; Bo Wu; Zhimin Shi



Influence of diesel injection parameters on end-of-injection liquid length recession.  

SciTech Connect

Diesel injection parameters effect on liquid-phase diesel spray penetration after the end-of-injection (EOI) is investigated in a constant-volume chamber over a range of ambient and injector conditions typical of a diesel engine. Our past work showed that the maximum liquid penetration length of a diesel spray may recede towards the injector after EOI at some conditions. Analysis employing a transient jet entrainment model showed that increased fuel-ambient mixing occurs during the fuel-injection-rate ramp-down as increased ambient-entrainment rates progress downstream (i.e. the entrainment wave), permitting complete fuel vaporization at distances closer to the injector than the quasi-steady liquid length. To clarify the liquid-length recession process, in this study we report Mie-scatter imaging results near EOI over a range of injection pressure, nozzle size, fuel type, and rate-of-injection shape. We then use a transient jet entrainment model for detailed analysis. Results show that an increased injection pressure correlates well with increasing liquid length recession due to an increased entrainment wave speed. Likewise, an increased nozzle size, with higher jet momentum and faster entrainment wave, enhances the liquid length recession. A low-density, high-volatility fuel does not decrease the strength of the entrainment wave; however, it decreases the steady liquid length causing the entrainment wave to reach the liquid spray tip earlier, which ultimately results in faster liquid length recession. A slow ramp down in injection rate causes a weaker entrainment wave so that the liquid length recession occurs even prior to injector close.

Kook, Sanghoon; Gemlich, Ryan K. (University of California - Davis); Musculus, Mark P. B.; Pickett, Lyle M.



Congenital adrenal hypoplasia and selective absence of pituitary luteinizing hormone: a new autosomal recessive syndrome.  


Congenital hypoplasia of the adrenal glands (CHA) is a rare condition, particularly in the absence of a central nervous system (CNS) anomaly. Two major types of CHA have been described in the setting of an apparently normal CNS and pituitary: a cytomegalic type usually with X-linked recessive inheritance and a miniature adult type that, when hereditary, is an autosomal recessive trait. Glycerol kinase deficiency (GKD) is an X-linked recessive trait, and it may be associated with CHA and adrenal insufficiency, presumably because of deletion of adjacent X-linked loci. We report on three sibling infants, one male and two females, with normal CNS and lethal CHA of the miniature adult type, selective absence of pituitary LH; two of the infants also had glycerol kinase (GK) activity that was decreased but not in the GKD range. Restriction fragment length polymorphism (RFLP) analysis of X chromosome markers located at Xp21-p22 was carried out on the maternal grandfather, both parents, two of three affected infants, and a living normal brother. The results excluded the X-linked type of this disorder associated with GKD in this family. Autosomal recessive inheritance is most likely. PMID:2906226

Burke, B A; Wick, M R; King, R; Thompson, T; Hansen, J; Darrae, B T; Francke, U; Seltzer, W K; McCabe, E R; Scheithauer, B W



A novel deletion mutation in LIPH gene causes autosomal recessive hypotrichosis (LAH2).  


Autosomal recessive hypotrichosis is a rare hereditary disorder characterized by sparse hair on scalp and rest of the body of affected subjects. Recently, three clinically similar autosomal recessive forms of hypotrichosis [localized autosomal recessive hypotrichosis (LAH)1], LAH2 and LAH3 have been mapped on chromosomes 18q12.1, 3q27.3, and 13q14.11-q21.32, respectively. For these three loci, two genes DSG4 for LAH1 and LIPH for LAH2 have been identified. To date, only five mutations in DSG4 and two in LIPH genes have been reported. In this study, we have ascertained two large unrelated consanguineous Pakistani families with autosomal recessive form of hypotrichosis. Affected individuals showed homozygosity to the microsatellite markers tightly linked to LIPH gene on chromosome 3q27. Sequence analysis of the gene in the affected subjects from both the families revealed a novel deletion mutation in exon 5 (c.659-660delTA) causing frameshift and downstream premature termination codon. All the three mutations identified in the LIPH gene, including the one in this study, are deletion mutations. PMID:18445047

Jelani, M; Wasif, N; Ali, G; Chishti, Ms; Ahmad, W



Efficient elliptic curve exponentiation  

Microsoft Academic Search

Elliptic curve cryptosystems, proposed by Koblitz([8]) andMiller([11]), can be constructed over a smaller definition field than theElGamal cryptosystems([5]) or the RSA cryptosystems([16]). This is whyelliptic curve cryptosystems have be un to attract notice. There aremainly two types in elliptic curve cryptosystems, elliptic curves E overIF 2 r and E over IFp . Some current systems based on ElGamal or RSAmay

Atsuko Miyaji; Takatoshi Ono; Henri Cohen



Urbanization and the global malaria recession  

PubMed Central

Background The past century has seen a significant contraction in the global extent of malaria transmission, resulting in over 50 countries being declared malaria free, and many regions of currently endemic countries eliminating the disease. Moreover, substantial reductions in transmission have been seen since 1900 in those areas that remain endemic today. Recent work showed that this malaria recession was unlikely to have been driven by climatic factors, and that control measures likely played a significant role. It has long been considered, however, that economic development, and particularly urbanization, has also been a causal factor. The urbanization process results in profound socio-economic and landscape changes that reduce malaria transmission, but the magnitude and extent of these effects on global endemicity reductions are poorly understood. Methods Global data at subnational spatial resolution on changes in malaria transmission intensity and urbanization trends over the past century were combined to examine the relationships seen over a range of spatial and temporal scales. Results/Conclusions A consistent pattern of increased urbanization coincident with decreasing malaria transmission and elimination over the past century was found. Whilst it remains challenging to untangle whether this increased urbanization resulted in decreased transmission, or that malaria reductions promoted development, the results point to a close relationship between the two, irrespective of national wealth. The continuing rapid urbanization in malaria-endemic regions suggests that such malaria declines are likely to continue, particularly catalyzed by increasing levels of direct malaria control.



Standard Decrement Curves  

Microsoft Academic Search

For circuit breaker and relay application, it is frequently necessary to determine the decrement in power system short-circuit currents. For this purpose certain ``standard decrement curves'' approved by the National Electrical Manufacturers Association have been in general use. The original curves appeared in 1918 and a revised set was prepared in 1923. New decrement curves given in the present paper

W. C. Hahn; C. F. Wagner



Fluctuation of Bed-load Solid Discharge and Grain Size Curve At Steep Slopes With Image Analysis Measurements  

NASA Astrophysics Data System (ADS)

Transfer of sediments from hillslope to channel is controlled by the building up of mor- phodynamic structures at different space and timescales (e.g. antidunes, step-pool sys- tem, alternate bars, braiding). One fundamental process allowing or enhancing those structures is grain size sorting. Bed-load experiments with non-uniform material are often hindered by the need of obtaining at the outlet of a flume the grain size distri- bution (gsd). The classical sieving method is indeed toilsome and time-consuming so that the number of samples is restrained which in turn does not allow a sufficiently fine temporal accuracy. A new device named GDS has been conceived for the mea- surement of Grain size Distribution and Solid discharge. At the outlet of any flume, the concentrated mixture of natural gravel and water is forced to flow on the GDS made of a backlit tilting transparent ramp above which is placed a motion camera. Image processing based on derivative operators and morphology allow to separate the particles to assess their dimensions in the image plane. Assuming that particles have an ellipsoid shape and flow in their stable state, it is possible to derive the volume of each particles. For solid discharge, it is also necessary to assess the mean particle velocity on the plate and the mean ratio of thickness to medium diameter. This device was successfully checked with test samples with an error generally less than 3% on grain size curve parameters and less than 7% on solid discharge. This device has then been used to study the fluctuations of bed load solid discharge and grain size distribu- tion at equilibrium steep slopes. Two series of experiments were performed in a 10 cm wide channel on a slope of 15 %, one with a uniform material (4-5 mm) and the other with non-uniform material (3-15 mm). Liquid flow rate and solid discharge per unit width were respectively of the order of 10 l/s/m and 3 kg/s/m. For the uniform ma- terial, fluctuations were small whereas they were large for the non-uniform material with the maximum solid discharge being twice the minimum value and the parameter d50 oscillating 10 % around the mean value. Moreover the higher solid discharge was associated with finer material whereas the lower solid discharge was coarser which was due to moving 1D bed structures.

Frey, Ph.; Ducottet, C.; Jay, J.


Severity of Prenatal Cocaine Exposure and Child Language Functioning Through Age Seven Years: A Longitudinal Latent Growth Curve Analysis  

PubMed Central

The current study estimates the longitudinal effects of severity of prenatal cocaine exposure on language functioning in an urban sample of full-term African-American children (200 cocaine-exposed, 176 noncocaine-exposed) through age 7 years. The Miami Prenatal Cocaine Study sample was enrolled prospectively at birth, with documentation of prenatal drug exposure status through maternal interview and toxicology assays of maternal and infant urine and infant meconium. Language functioning was measured at ages 3 and 5 years using the Clinical Evaluation of Language Fundamentals–Preschool (CELF-P) and at age 7 years using the Core Language Domain of the NEPSY: A Developmental Neuropsychological Assessment. Longitudinal latent growth curve analyses were used to examine two components of language functioning, a more stable aptitude for language performance and a time-varying trajectory of language development, across the three time points and their relationship to varying levels of prenatal cocaine exposure. Severity of prenatal cocaine exposure was characterized using a latent construct combining maternal self-report of cocaine use during pregnancy by trimesters and maternal and infant bioassays, allowing all available information to be taken into account. The association between severity of exposure and language functioning was examined within a model including factors for fetal growth, gestational age, and IQ as intercorrelated response variables and child’s age, gender, and prenatal alcohol, tobacco, and marijuana exposure as covariates. Results indicated that greater severity of prenatal cocaine exposure was associated with greater deficits within the more stable aptitude for language performance (D = ?0.071, 95% CI = ?0.133, ?0.009; p = 0.026). There was no relationship between severity of prenatal cocaine exposure and the time-varying trajectory of language development. The observed cocaine-associated deficit was independent of multiple alternative suspected sources of variation in language performance, including other potential responses to prenatal cocaine exposure, such as child’s intellectual functioning, and other birth and postnatal influences, including language stimulation in the home environment.

Bandstra, Emmalee S.; Vogel, April L.; Morrow, Connie E.; Xue, Lihua; Anthony, James C.



Numerical simulation of flows in curved diffusers with cross-sectional transitioning using a three-dimensional viscous analysis  

NASA Astrophysics Data System (ADS)

A three dimensional analysis for fully viscous, subsonic, compressible flow is evaluated. An approximate form of the Navier Stokes equations is solved by an implicit spatial marching technique. Calculations were made for flow in a circular S duct and in the F 16 inlet duct. The computed total pressure contours and secondary flow velocity vectors are presented. Qualitative comparisons with experiment are shown for both ducts. The analysis is used to show how the cross section transitioning in the F 16 inlet suppresses the development of a secondary flow vortex.

Towne, C. E.; Anderson, B. H.



Financial analysis of circumferential fusion versus posterior-only with thoracic pedicle screw constructs for main thoracic idiopathic curves between 70? and 100?  

PubMed Central

Purpose Reports on thoracic pedicle screw (TPS) constructs have demonstrated their safety and efficacy; however, concerns exist regarding their increased cost. This is a review of adolescents with main thoracic scoliosis surgically treated with anterior release and posterior fusion or posterior fusion only. The objectives were to compare the radiographic outcomes and financial data of two surgical treatments: anterior/posterior spinal fusion (APSF) versus posterior spinal fusion (PSF-TPS) alone with TPSs, in patients with large 70–100° main thoracic adolescent idiopathic scoliosis (AIS) curves. Methods We identified 43 patients with main thoracic Lenke type 1–4 AIS curves between 70 and 100° who had been treated with either APSF or PSF-TPS. Results Both groups had equivalent radiographic corrections postoperatively. The PSF-TPS group patients had higher implant charges, but the APSF group had higher surgeon procedural charges, operating room charges, anesthesia charges, and inpatient room charges. Total charges were $75,295 for the APSF group and $71,236 for the PSF-TPS group (P > 0.05). Analyses of two subgroups of the APSF group, anterior release via thoracotomy versus VATS and same-day versus staged surgeries, failed to change any of the above findings. Conclusion Based on this financial analysis, there was no statistically significant differences between the APSF and PSF-TPS groups, with equivalent radiographic corrections.

Lenke, Lawrence G.; Kim, Yongjung J.; Bridwell, Keith H.; Schootman, Mario



A statistical model for the analysis and prediction of the effect of neutron irradiation on Charpy impact energy curves  

Microsoft Academic Search

The structural integrity safety assessments of nuclear reactor pressure vessels are based, in part, on a prediction of the effect of neutron irradiation on material properties. Databases which monitor this effect are often made up of Charpy absorbed energy measurements. This article presents a generally applicable, new and statistically rigorous method of analysis in which any prior belief as to

P. L. Windle; M. Crowder; R. Moskovic



Time Series and Growth Curves Part 1 Survey of Time Series Analysis . Zeitreihen und Wachstumskurven Teil 1 Ueberblick ueber Zeitreihenanalysen.  

National Technical Information Service (NTIS)

The possibilities are described for using time series analysis in prognosis and planning. Time series are the most important basis of information for all long term prognoses and planning. In view of the increasing importance of long term planning in telec...

H. Petersen